Source: http://www.mauricewilkinscentre.org/sub-pages/publications/scientific-publications.aspx?year=2017
Timestamp: 2019-04-21 16:45:13+00:00

Document:
Ahn, A., A. Chatterjee and M. R. Eccles, The slow cycling phenotype: A growing problem for treatment resistance in melanoma. Molecular Cancer Therapeutics (2017) 16(6): 1002-1009.
Alexander, S. R., D. Lim, Z. Amso, M. A. Brimble and A. J. Fairbanks, Protecting group free synthesis of glycosyl thiols from reducing sugars in water; application to the production of N-glycan glycoconjugates. Organic and Biomolecular Chemistry (2017) 15(10): 2152-2156.
Anderson, R. J., J. Li, L. Kedzierski, B. J. Compton, C. M. Hayman, T. L. Osmond, C. W. Tang, K. J. Farrand, H. F. Koay, C. F. D. S. E. Almeida, L. R. Holz, G. M. Williams, M. A. Brimble, Z. F. Wang, M. Koutsakos, K. Kedzierska, D. I. Godfrey, I. F. Hermans, S. J. Turner and G. F. Painter, Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine. ACS Chemical Biology (2017) 12(11): 2898-2905.
Aung, H. L., W. W. Nyunt, Y. Fong, G. M. Cook and S. T. Aung, First 2 Extensively Drug-Resistant Tuberculosis Cases From Myanmar Treated With Bedaquiline. Clinical Infectious Diseases (2017) 65(3): 531-532.
Badrinarayanan, S., C. J. Squire, J. Sperry and M. A. Brimble, Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B. Organic Letters (2017) 19(13): 3414-3417.
Blaza, J. N., H. R. Bridges, D. Aragao, E. A. Dunn, A. Heikal, G. M. Cook, Y. Nakatani and J. Hirst, The mechanism of catalysis by type-II NADH: quinone oxidoreductases. Scientific Reports (2017) 7: 40165.
Booker, C. S. and D. R. Grattan, IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Journal of Immunology (2017) 198(1): 270-278.
Brown, R. S. E., M. Aoki, S. R. Ladyman, H. R. Phillipps, A. Wyatt, U. Boehm and D. R. Grattan, Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. Proceedings of the National Academy of Sciences of the United States of America (2017) 114(40): 10779-10784.
Chatterjee, A., E. C. MacAulay, A. Ahn, J. L. Ludgate, P. A. Stockwell, R. J. Weeks, M. F. Parry, T. J. Foster, I. M. Knarston, M. R. Eccles and I. M. Morison, Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics (2017) 9(6): 823-832.
Chatterjee, A., P. A. Stockwell, A. Ahn, E. J. Rodger, A. L. Leichter and M. R. Eccles, Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis. Oncotarget (2017) 8(4): 6085-6101.
Choi, H., H. J. Shirley, P. A. Hume, M. A. Brimble and D. P. Furkert, Unexpected Direct Synthesis of N-Vinyl Amides through Vinyl Azide–Enolate [3+2] Cycloaddition. Angewandte Chemie - International Edition (2017) 56(26): 7420-7424.
Choi, P. J., H. S. Sutherland, A. S. T. Tong, A. Blaser, S. G. Franzblau, C. B. Cooper, M. U. Lotlikar, A. M. Upton, J. Guillemont, M. Motte, L. Queguiner, K. Andries, W. Van den Broeck, W. A. Denny and B. D. Palmer, Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic & Medicinal Chemistry Letters (2017) 27(23): 5190-5196.
Chowdhury, M. K. H., N. Turner, N. L. Bentley, A. Das, L. E. Wu, D. Richani, S. Bustamante, R. B. Gilchrist, M. J. Morris, P. R. Shepherd and G. C. Smith, Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes. Scientific Reports (2017) 7: 40159.
Cooper, A., S. Singh, S. Hook, J. D. A. Tyndall and A. J. Vernall, Chemical tools for studying lipid-binding class a g protein–coupled receptors. Pharmacological Reviews (2017) 69(3): 316-353.
da Silva, K. S., P. R. Pinto, N. T. Fabre, D. J. Gomes, K. Thieme, L. S. Okuda, R. T. Iborra, V. G. Freitas, M. H. M. Shimizu, W. R. Teodoro, S. K. N. Marie, T. Woods, M. A. Brimble, R. Pickford, K.-A. Rye, M. Okamoto, S. Catanozi, M. L. Correa-Giannela, U. F. Machado and M. Passarelli, N-acetylcysteine Counteracts Adipose Tissue Macrophage Infiltration and Insulin Resistance Elicited by Advanced Glycated Albumin in Healthy Rats. Frontiers in Physiology (2017) 8: 723.
Dalton, J. P., B. Uy, K. S. Okuda, C. J. Hall, W. A. Denny, P. S. Crosier, S. Swift and S. Wiles, Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model. Journal of Antimicrobial Chemotherapy (2017) 72(2): 421-427.
De Leon-Rodriguez, L. M., Y. Hemar, A. K. Mitra and M. A. Brimble, Understanding the metal mediated assembly and hydrogel formation of a [small beta]-hairpin peptide. Biomaterials Science (2017) 5(10): 1993-1997.
De Leon-Rodriguez, L. M., Y. Hemar, G. Mo, A. K. Mitra, J. Cornish and M. A. Brimble, Multifunctional thermoresponsive designer peptide hydrogels. Acta Biomaterialia (2017) 47: 40-49.
Ding, X. B., D. P. Furkert and M. A. Brimble, General synthesis of the nitropyrrolin family of natural products via regioselective CO<inf>2</inf>-mediated alkyne hydration. Organic Letters (2017) 19(19): 5418-5421.
Dissanayake, S., W. A. Denny, S. Gamage and V. Sarojini, Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. Journal of Controlled Release (2017) 250: 62-76.
Evans, G. L., D. P. Furkert, N. Abermil, P. Kundu, K. M. de Lange, E. J. Parker, M. A. Brimble, E. N. Baker and J. S. Lott, Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups. Data in Brief (2017) 15: 1019-1029.
Evans, G. L., D. P. Furkert, N. Abermil, P. Kundu, K. M. de Lange, E. J. Parker, M. A. Brimble, E. N. Baker and J. S. Lott, Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha-D-ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design. Biochimica et Biophysica Acta - Proteins and Proteomics (Epub 2017) DOI: 10.1016/j.bbapap.2017.08.018.
Field, C. S., M. K. Hunn, P. M. Ferguson, C. Ruedl, L. R. Ancelet and I. F. Hermans, Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model. OncoImmunology (Epub 2017) DOI: 10.1080/2162402X.2017.1376154.
Gamage, S. A., A. C. Giddens, K. Y. Tsang, J. U. Flanagan, J. D. Kendall, W. J. Lee, B. C. Baguley, C. M. Buchanan, S. M. F. Jamieson, P. R. Shepherd, W. A. Denny and G. W. Rewcastle, Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic & Medicinal Chemistry (2017) 25(20): 5859-5874.
Gasser, O., K. J. Sharples, C. Barrow, G. M. Williams, E. Bauer, C. E. Wood, B. Mester, M. Dzhelali, G. Caygill, J. Jones, C. M. Hayman, V. A. Hinder, J. Macapagal, M. McCusker, R. Weinkove, G. F. Painter, M. A. Brimble, M. P. Findlay, P. R. Dunbar and I. F. Hermans, A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and alpha-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients. Cancer Immunol Immunother (Epub 2017) DOI: 10.1007/s00262-017-2085-9.
Gong, G. Q., J. D. Kendall, J. M. J. Dickson, G. W. Rewcastle, C. M. Buchanan, W. A. Denny, P. R. Shepherd and J. U. Flanagan, Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity. Biochemical Journal (2017) 474(13): 2261-2276.
Gustafson, P., S. J. Bunn and G. D. R., The role of prolactin in the suppression of Crh mRNA expression during pregnancy and lactation in the mouse. Journal of Neuroendocrinology (2017) 29(9): e12511.
Hanson-Manful, P., A. L. Whitcombe, P. G. Young, P. E. Atatoa Carr, A. Bell, A. Didsbury, E. A. Mitchell, P. R. Dunbar, T. Proft and N. J. Moreland, The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. J Infect (Epub 2017) DOI: 10.1016/j.jinf.2017.12.008.
Hards, K. and G. M. Cook, Targeting bacterial energetics to produce new antimicrobials. Drug Resistance Updates (Epub 2017) DOI: https://doi.org/10.1016/j.drup.2017.11.001.
Harris, P. W. R., G. M. Cook, I. K. H. Leung and M. A. Brimble, An Efficient Chemical Synthesis of Lassomycin Enabled by an On-Resin Lactamisation-Off-Resin Methanolysis Strategy and Preparation of Chemical Variants. Australian Journal of Chemistry (2017) 70(2): 172-183.
Hobbs, J. K., W. T. Jiao, A. D. Easter, E. J. Parker, L. A. Schipper and V. L. Arcus, Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates. ACS Chemical Biology (2017) 12(3): 868-868.
Hung, K. Y., P. W. R. Harris, A. Desai, J. F. Marshall and M. A. Brimble, Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality. European Journal of Medicinal Chemistry (2017) 136: 154-164.
Jamieson, M. L., N. Z. Brant, M. A. Brimble and D. P. Furkert, Remarkable Influence of Cobalt Catalysis on Epoxide Ring-Opening with Sulfoxonium Ylides. Synthesis (Germany) (2017) 49(17): 3952-3956.
Jayasinghe, T. N., C. Hilton, P. Tsai, B. Apple, P. Shepherd, W. S. Cutfield and J. M. O'Sullivan, Long-term stability in the gut microbiome over 46 years in the life of Billy Apple®. Human Microbiome Journal (2017) 5-6: 7-10.
Jiao, W., N. J. Blackmore, A. R. Nazmi and E. J. Parker, Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. PLoS ONE (2017) 12(6): e0180052.
Kalia, N. P., E. J. Hasenoehrl, N. B. Ab Rahman, V. H. Koh, M. L. T. Ang, D. R. Sajorda, K. Hards, G. Grüber, S. Alonso, G. M. Cook, M. Berney and K. Pethe, Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proceedings of the National Academy of Sciences of the United States of America (2017) 114(28): 7426-7431.
Kamato, D., P. Mitra, F. Davis, N. Osman, R. Chaplin, P. J. Cabot, R. Afroz, W. Thomas, W. Zheng, H. Kaur, M. Brimble and P. J. Little, Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences (2017) 74(8): 1379-1390.
Kavianinia, I., S. H. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks and M. A. Brimble, Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides. Chemical Communications (2017) 53(60): 8459-8462.
Kazantseva, M., N. A. Hung, S. Mehta, I. Roth, R. Eiholzer, A. M. Rich, B. Seo, M. A. Baird, A. W. Braithwaite and T. L. Slatter, Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports (2017) 7(1): 1566.
Kendall, J. D., A. C. Giddens, K. Y. Tsang, E. S. Marshall, C. L. Lill, W. J. Lee, S. Kolekar, M. Chao, A. Malik, S. Yu, C. Chaussade, C. Buchanan, S. M. F. Jamieson, G. W. Rewcastle, B. C. Baguley, W. A. Denny and P. R. Shepherd, Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters (2017) 27(2): 187-190.
Kim, Y., J. M. Griffin, P. W. R. Harris, S. H. C. Chan, L. F. B. Nicholson, M. A. Brimble, S. J. O'Carroll and C. R. Green, Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model. Biochimica et Biophysica Acta - General Subjects (2017) 1861(2): 68-78.
Kueh, J. T. B., N. J. Stanley, R. J. Hewitt, L. M. Woods, L. Larsen, J. C. Harrison, D. Rennison, M. A. Brimble, I. A. Sammut and D. S. Larsen, Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science (2017) 8(8): 5454-5459.
Kwon, H., P. G. Young, C. J. Squire and E. N. Baker, Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability. Scientific Reports (2017) 7: 42753.
Ladyman, S. R. and D. R. Grattan, Region-specific suppression of hypothalamic responses to insulin to adapt to elevated maternal insulin secretion during pregnancy. Endocrinology (2017) 158(12): 4257-4269.
Ladyman, S. R., M. A. MacLeod, Z. Khant Aung, P. Knowles, H. R. Phillipps, R. S. E. Brown and D. R. Grattan, Prolactin receptors in Rip-cre cells, but not in AgRP neurones, are involved in energy homeostasis. J Neuroendocrinol (2017) 29(10): e12474.
Langley, R. J., Y. T. Ting, F. Clow, P. G. Young, F. J. Radcliff, J. M. Choi, R. P. Sequeira, S. Holtfreter, H. Baker and J. D. Fraser, Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. PLoS Pathogens (2017) 13(9): e1006549.
Leichter, A. L., M. J. Sullivan, M. R. Eccles and A. Chatterjee, MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours. Molecular Cancer (2017) 16(1): 15.
Leroy, B., M. L. Ballinger, F. Baran-Marszak, G. L. Bond, A. Braithwaite, N. Concin, L. A. Donehower, W. S. El-Deiry, P. Fenaux, G. Gaidano, A. Langerød, E. Hellstrom-Lindberg, R. Iggo, J. Lehmann-Che, P. L. Mai, D. Malkin, U. M. Moll, J. N. Myers, K. E. Nichols, S. Pospisilova, P. Ashton-Prolla, D. Rossi, S. A. Savage, L. C. Strong, P. N. Tonin, R. Zeillinger, T. Zenz, J. F. Fraumeni, P. E. M. Taschner, P. Hainaut and T. Soussi, Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice. Cancer Research (2017) 77(6): 1250-1260.
Li, X., C. P. Guise, R. Taghipouran, Y. Yosaatmadja, A. Ashoorzadeh, W. K. Paik, C. J. Squire, S. Jiang, J. Luo, Y. Xu, Z. C. Tu, X. Lu, X. Ren, A. V. Patterson, J. B. Smaill and K. Ding, 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. European Journal of Medicinal Chemistry (2017) 135: 531-543.
Lorenz, N., J. M. S. Loh, N. J. Moreland and T. Proft, Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence. Journal of Microbiological Methods (2017) 134: 58-61.
Ludgate, J. L., J. Wright, P. A. Stockwell, I. M. Morison, M. R. Eccles and A. Chatterjee, A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics (2017) 10: 54.
Lutteroth, K. R., P. W. R. Harris, T. H. Wright, H. Kaur, K. Sparrow, S. H. Yang, G. J. S. Cooper and M. A. Brimble, Incorporation of 'click' chemistry glycomimetics dramatically alters triple-helix stability in an adiponectin model peptide. Organic and Biomolecular Chemistry (2017) 15(26): 5602-5608.
Mason, J. M., H. Yuan, G. B. Evans, P. C. Tyler, Q. Du and V. L. Schramm, Oligonucleotide transition state analogues of saporin L3. Eur J Med Chem (2017) 127: 793-809.
McGrath, A. J., C. Dolan, S. Cheong, D. A. J. Herman, B. Naysmith, F. Zong, P. Galvosas, K. J. Farrand, I. F. Hermans, M. Brimble, D. E. Williams, J. Jin and R. D. Tilley, Stability of polyelectrolyte-coated iron nanoparticles for T2-weighted magnetic resonance imaging. Journal of Magnetism and Magnetic Materials (2017) 439: 251-258.
Medini, K., B. West, D. E. Williams, M. A. Brimble and J. A. Gerrard, MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly. Chemical Communications (2017) 53(10): 1715-1718.
Mittelstädt, G., W. Jiao, E. K. Livingstone, G.-J. Moggré, A. R. Nazmi and E. J. Parker, A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase. Biochemical Journal (Epub 2017) DOI: 10.1042/BCJ20170762.
Mo, C., Z. Zhang, C. P. Guise, X. Li, J. Luo, Z. Tu, Y. Xu, A. V. Patterson, J. B. Smaill, X. Ren, X. Lu and K. Ding, 2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors. ACS Medicinal Chemistry Letters (2017) 8(5): 543-548.
Moggre, G. J., M. B. Poulin, P. C. Tyler, V. L. Schramm and E. J. Parker, Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase. ACS Chemical Biology (2017) 12(10): 2662-2670.
Mountjoy, K. G., A. Caron, K. Hubbard, A. Shome, A. C. Grey, B. Sun, S. Bould, M. Middleditch, B. Pontre, A. McGregor, P. W. R. Harris, R. Kowalczyk, M. A. Brimble, R. Botha, K. M. L. Tan, S. J. Piper, C. Buchanan, S. Lee, A. P. Coll and J. K. Elmquist, Desacetyl-alpha-melanocyte stimulating hormone and alpha-melanocyte stimulating hormone are required to regulate energy balance. Mol Metab (Epub 2017) DOI: 10.1016/j.molmet.2017.11.008.
Mulholland, C. V., A. Ruthe, R. T. Cursons, R. Durrant, N. Karalus, K. Coley, J. Bower, E. Permina, M. J. Coleman, S. A. Roberts, V. L. Arcus, G. M. Cook and H. L. Aung, Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand. Diagnostic Microbiology and Infectious Disease (2017) 88(2): 138-140.
Murphy, R., P. Tsai, M. Jüllig, A. Liu, L. Plank and M. Booth, Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission. Obesity Surgery (2017) 27(4): 917-925.
Nakatani, Y., W. T. Jiao, D. Aragao, Y. Shimaki, J. Petri, E. J. Parker and G. M. Cook, Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 angstrom. Acta Crystallographica Section F-Structural Biology Communications (2017) 73: 541-549.
Nakatani, Y., H. K. Opel-Reading, M. Merker, D. Machado, S. Andres, S. S. Kumar, D. Moradigaravand, F. Coll, J. Perdigão, I. Portugal, T. Schön, D. Nair, K. R. U. Devi, T. A. Kohl, P. Beckert, T. G. Clark, G. Maphalala, D. Khumalo, R. Diel, K. Klaos, H. L. Aung, G. M. Cook, J. Parkhill, S. J. Peacock, S. Swaminathan, M. Viveiros, S. Niemann, K. L. Krause and C. U. Köser, Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance. Antimicrobial Agents and Chemotherapy (2017) 61(12): e01575-01517.
Namanja-Magliano, H. A., G. B. Evans, R. K. Harijan, P. C. Tyler and V. L. Schramm, Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis. Biochemistry (2017) 56(38): 5090-5098.
Naysmith, B. J., P. A. Hume, J. Sperry and M. A. Brimble, Pyranonaphthoquinones-isolation, biology and synthesis: An update. Natural Product Reports (2017) 34(1): 25-61.
Nyunt, W. W., S. T. Aung, G. M. Cook and H. L. Aung, Evaluation of the genotype MTBDRsl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases (2017) 49(11-12): 865-866.
Nyunt, W. W., S. T. Aung, T. Lwin, G. M. Cook and H. L. Aung, First- and second-line antituberculosis drug resistance patterns among previous treatment failure patients in Myanmar. Journal of Global Antimicrobial Resistance (2017) 9: 34-35.
Pantin, M., J. G. Hubert, T. Söhnel, M. A. Brimble and D. P. Furkert, Stereochemical Characterization of Polyketide Stereotriads Synthesized via Hydrogen-Mediated Asymmetric syn-Crotylation. Journal of Organic Chemistry (2017) 82(20): 11225-11229.
Quach, R., D. P. Furkert and M. A. Brimble, Gold catalysis: synthesis of spiro, bridged, and fused ketal natural products. Organic and Biomolecular Chemistry (2017) 15(15): 3098-3104.
Radcliff, F. J., F. Clow, M. Mahadevan, J. Johnston, T. Proft, R. G. Douglas and J. D. Fraser, A potential role for staphylococcal and streptococcal superantigens in driving skewing of TCR Vbeta subsets in tonsillar hyperplasia. Med Microbiol Immunol (2017) 206(4): 337-346.
Rewcastle, G. W., S. Kolekar, C. M. Buchanan, S. A. Gamage, A. C. Giddens, K. Y. Tsang, J. D. Kendall, R. Singh, W. J. Lee, G. C. Smith, W. Han, D. J. Matthews, W. A. Denny, P. R. Shepherd and S. M. F. Jamieson, Biological characterization of SN32976, a selective inhibitor of PI3κ and mTOR with preferential activity to PI3κα, in comparison to established pan PI3κ inhibitors. Oncotarget (2017) 8(29): 47725-47740.
Rizwan, M. Z., S. Mehlitz, D. R. Grattan and A. Tups, Temporal and regional onset of leptin resistance in diet-induced obese mice. Journal of Neuroendocrinology (2017) 29(10): e12481.
Salio, M., O. Gasser, C. Gonzalez-Lopez, A. Martens, N. Veerapen, U. Gileadi, J. G. Verter, G. Napolitani, R. Anderson, G. Painter, G. S. Besra, I. F. Hermans and V. Cerundolo, Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells. J Immunol (2017) 199(8): 2631-2638.
Schumacher, C. E., P. W. R. Harris, X. B. Ding, B. Krause, T. H. Wright, G. M. Cook, D. P. Furkert and M. A. Brimble, Synthesis and biological evaluation of novel teixobactin analogues. Organic and Biomolecular Chemistry (2017) 15(41): 8755-8760.
Siow, A., K. y. Hung, P. W. R. Harris and M. A. Brimble, Solid-Phase Synthesis of the Peptaibol Alamethicin U-22324 by Using a Double-Linker Strategy. European Journal of Organic Chemistry (2017) 2017(2): 350-354.
Speir, M., A. Authier-Hall, C. R. Brooks, K. J. Farrand, B. J. Compton, R. J. Anderson, A. Heiser, T. L. Osmond, C. W. Tang, J. A. Berzofsky, M. Terabe, G. F. Painter, I. F. Hermans and R. Weinkove, Glycolipid-peptide conjugate vaccines enhance CD8(+) T cell responses against human viral proteins. Sci Rep (2017) 7(1): 14273.
Speir, M., I. F. Hermans and R. Weinkove, Engaging Natural Killer T Cells as ‘Universal Helpers’ for Vaccination. Drugs (2017) 77(1): 1-15.
Spicer, J. A., C. K. Miller, P. D. O'Connor, J. Jose, K. M. Huttunen, J. K. Jaiswal, W. A. Denny, H. Akhlaghi, K. A. Browne and J. A. Trapani, Benzenesulphonamide inhibitors of the cytolytic protein perforin. Bioorganic & Medicinal Chemistry Letters (2017) 27(4): 1050-1054.
Spicer, J. A., C. K. Miller, P. D. O'Connor, J. Jose, K. M. Huttunen, J. K. Jaiswal, W. A. Denny, H. Akhlaghi, K. A. Browne and J. A. Trapani, Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. European Journal of Medicinal Chemistry (2017) 137: 139-155.
Strauss, O., A. Phillips, K. Ruggiero, A. Bartlett and P. R. Dunbar, Immunofluorescence identifies distinct subsets of endothelial cells in the human liver. Scientific Reports (2017) 7: 44356.
Stubbing, L. A., I. Kavianinia and M. A. Brimble, Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics. Organic and Biomolecular Chemistry (2017) 15(17): 3542-3549.
Thompson, A. M., P. D. O’Connor, A. J. Marshall, V. Yardley, L. Maes, S. Gupta, D. Launay, S. Braillard, E. Chatelain, S. G. Franzblau, B. Wan, Y. Wang, Z. Ma, C. B. Cooper and W. A. Denny, 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. Journal of Medicinal Chemistry (2017) 60(10): 4212-4233.
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Zhang, S., L. M. De Leon Rodriguez, E. Lacey, A. M. Piggott, I. K. H. Leung and M. A. Brimble, Cyclization of Linear Tetrapeptides Containing N-Methylated Amino Acids by using 1-Propanephosphonic Acid Anhydride. European Journal of Organic Chemistry (2017) 2017(1): 149-158.
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