Source: http://www.massey.ac.nz/massey/expertise/profile.cfm?stref=738930
Timestamp: 2019-04-21 10:16:03+00:00

Document:
Scientific curiosity and passion have driven my academic career and enabled me to become an expert in the physico-chemical analysis of many different DNA secondary structures, such as duplexes, triplexes and G-quadruplexes. My work on highly-specific flexible intercalating units embedded into DNA led to the discovery of a novel class of molecules (twisted intercalating nucleic acid, TINA) that enables formation of stable DNA triplexes or G-quadruplexes. This work has laid the foundation for the 1st Platform.
My interest in development of novel tools for chemists inspired by Nature is behind the research on DNA-based chiral catalysis (Platform 2), while my research activity in the field of assembly of organic chromophores on the DNA scaffold is behind the project on DNA-based low-energy photon upconverters (Platform 3).
My knowledge in the functionalisation and manipulation of DNA on the pre- and post-synthetic level is pivotal for the success of these projects.
Filitcheva, J., Edwards, PJB., Norris, GE., & Filichev, VV. (2019). α-2'-Deoxyguanosine can switch DNA G-quadruplex topologies from antiparallel to parallel.. Org Biomol Chem.
[Journal article]Authored by: Edwards, P., Filichev, V., Norris, G.
Su, Y., Fujii, H., Burakova, EA., Chelobanov, BP., Fujii, M., Stetsenko, DA., . . . Filichev, VV. (2019). Neutral and Negatively Charged Phosphate Modifications Altering Thermal Stability, Kinetics of Formation and Monovalent Ion Dependence of DNA G-Quadruplexes. Chemistry - An Asian Journal.
[Journal article]Authored by: Filichev, V.
[Journal article]Authored by: Filichev, V., Harjes, E., Harjes, S., Jameson, G., Kvach, M.
[Journal article]Authored by: Edwards, P., Filichev, V., Harjes, E., Harjes, S., Jameson, G.
[Journal article]Authored by: Filichev, V., Keen, S., Raudsepp, A., Williams, M.
[Journal article]Authored by: Filichev, V., Keen, S., Williams, M.
[Journal article]Authored by: Edwards, P., Filichev, V.
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Norris, G.
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T.
[Journal article]Authored by: Filichev, V., Rowlands, G.
Doluca, O., Hale, TK., & Filichev, VV.(2013). . 609844: Assembly-dependent Fluorescence Enhancing Nucleic Acids (AFENA) in Sequence-specific Detection of Nucleic Acids in Fluorescence Assay.
[Patent]Authored by: Filichev, V., Hale, T.
Filichev, VV., & Pedersen, EB.(2011). . 564146: New Zealand, published and granted: Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA.
Bao, LT., Herdewijn, P., Filichev, VV., Wilton, SD., Fletcher, S., & Veedu, RN.EXPLORING NOVEL THERAPEUTIC CHEMISTRIES IN EXON-SKIPPING FOR DUCHENNE MUSCULAR DYSTROPHY. JOURNAL OF GENE MEDICINE. 20 (1)1099-498X.
Harjes, E., Harjes, S., Filichev, V., Jameson, GB., & Edwards, P.(2016, October). How DNA mutating enzymes interact with their DNA substrates. .
[Conference]Authored by: Edwards, P., Filichev, V., Harjes, E., Harjes, S., Jameson, G.
[Conference Abstract]Authored by: Filichev, V., Harjes, E., Harjes, S., Jameson, G., Kvach, M.
[Conference Abstract]Authored by: Filichev, V.
[Conference Poster]Authored by: Filichev, V.
Filichev, VV. (2011, June). G-rich sequences and intercalating nucleic acids: G-quadruplexes versus antiparallel triplexes. Presented at Third International Meeting on G-Quadruplex and G-assembly. Sorrento, Italy.
[Conference Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2011, June). Synthesis of β-pyrrolic modified porphyrins and their incorporation into DNA. Presented at 3rd NAC Mini-Symposium - Nucleic Acid Chemical Biology anno 2011. University of Southern Denmark, Odense, Denmark.
Boutorine, AS., Doluca, O., & Filichev, VV. (2009). Optimization of the sequence of twisted intercalating nucleic acids (TINA) forming triple helix with the polypurine tract of the proviral HIV DNA.. Nucleic acids symposium series (2004). (pp. 139 - 140).
[Conference Paper in Published Proceedings]Authored by: Filichev, V.
Stephenson, AW., Filichev, VV., & Partridge, A. (2008). DNA scaffolded porphyrins for light harvesting applications. In AMN4 Advanced Materials and Nanotechnology Conference: The MacDiamid Institute for Advanced Materials and Nanotechnology.
Pedersen, EB., Osman, AMA., Globisch, D., Paramasivam, M., Cogoi, S., Bomholt, N., . . . Filichev, VV. (2008). Triplex glue by synthesizing conjugated flexible intercalators.. Nucleic acids symposium series (2004). (pp. 37 - 38).
Filichev, VV., Astakhova, IV., Malakhov, AD., Korshun, VA., & Pedersen, EB. (2008). DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids (TINAs), DNA duplexes/triplexes and interstrand excimer formation.. Nucleic acids symposium series (2004). (pp. 347 - 348).
[Conference Poster]Authored by: Filichev, V., Rowlands, G.
Filichev, VV. (2006, December). DNA glue: Flexible intercalating systems and DNA triplexes. Presented at Back to the Basics: From Small Molecules to Materials and Surfaces: New Zealand Institute of Chemistry (NZIC) 2006 Conference. Rotorua, NZ.
Geci, I., Filichev, VV., & Pedersen, EB.(2005, September). Synthesis of twisted intercalating nucleic acids (TINA) possesing acridine derivatives. Chemistry of Nucleic Acid Components. (pp. 401 - 402).
Filichev, VV. (2009). DNA glue: Intercalating nucelic acids and dsdna targeting. Presented at St Ptersburg State Technological Institute (Technical University), St Petersburg, Russia.
[Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2009). DNA glue: Intercalating nucleic acids and dsdna targeting. Presented at Kirchhoff Institute of Physics, Heidelberg University.
Filichev, VV. (2008). DNA Glue: Intercalating nucleic acids and dsDNA targeting. Presented at Palmerston North, New Zealand.
Filichev, VV. (2007). Intercalating nucleic acids and dsDNA targeting: Strand invasion, inhibition of transcription, triplex formation. Presented at Victoria University of Wellington, NZ.
Filichev, VV. (2007). DNA glue: Intercalating nucleic acids and dsDNA targeting. Presented at University of Southern Denmark, Odense, Denmark.
Filichev, VV. (2007). Intercalating nucleic acids and dsDNA targeting: Strand invasion, inhibition of transcription, triplex formation. Presented at Massey University, Palmerston North, NZ.

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