Source: http://ctcusp.org/dimas-tadeu-covas/
Timestamp: 2019-04-19 01:19:17+00:00

Document:
1. Mesenchymal Stem Cell – isolation, functional characterization, production on a large scale in bioreactors, biodistribution and clinical potential of isolated MSC of diverse tissues as feral adnexa, umbilical cord, vascular fraction of the adipose tissue and bone marrow. We are also developing clinical studies of phase I in diabetes type I, on GVHD and in aplastic anemia.
2. Embryonic Stem Cell – induction of the hematopoietic and endothelial differentiation with the objective to get therapeutically amounts of platelets, erythrocyte and endothelial cells.
3. Generation of lineages of Induced Pluripotent Stem Cells (iPS) from fibroblasts of hemophilic and osteogenesis imperfect patients for the study of mechanisms and establishment of pluripotent cellular lineages with corrected genome aiming future therapeutic use.
4. Direct reprogramming of fibroblasts or keratinocytes from normal individuals into hematopoietic stem cell aiming at studies of mechanisms and of ideal combination of genes for induction of the reprogramming.
5. Molecular and genetic mechanisms involved in the epithelial-mesenchymal transition (EMT), endothelial-mesenchymal (EndMT) and their reverses MET and MEndT, mainly in the process of induction of the tumor metastasis and in the generation of cancer stem cells.
6. Production of recombinant proteins, mainly of the coagulation factors VIII, IX and VII.
7. Development of molecular tests for detection of viral illnesses transmitted by cellular products.
Gregory J. Riggins, M.D. Ph.D.
1. Ferreira, AF; Moura, LG. ; Tojal, I. ; Ambrósio, L; Pinto-Simões, B; Hamerschlak, N; Calin, GA; Ivan, C; Covas, DT; Kashima, S; Castro, FA. ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance. Blood Cells, Molecules & Diseases (Print), v. 53, p. 47-55, 2014.
2. De Santis, GC; Prata, KL; Rodrigues, RB; Sankarankutty, AK; De Castro e Silva, O; Covas, DT. Blood group O patients require more blood transfusion in orthotopic liver transplantation. Transfusion and Apheresis Science, v. 14, p. 9, 2014.
3. Picanço-Castro, V; Moreira, LF; Kashima, S; Covas, DT. Can Pluripotent Stem Cells Be Used in Cell-Based Therapy?. Cellular Reprogramming, v. 1, p. 140307082255007, 2014.
4. Slavov, SN; Kashima, S; Rocha-Junior, MC; Oliveira, LC; Silva-Pinto, AC; Yamamoto, AY; Covas, DT. Frequent human parvovirus B19 DNA occurrence and high seroprevalence in haemophilic patients from a non-metropolitan blood centre, Brazil. Transfusion Medicine (Print), v. 24, p. 130-132, 2014.
5. Rodrigues, ES; De Macedo, MD; Pinto, MT; Orellana, MD; Rocha Junior, MC; De Magalhães, DAR; Tanaka, Y; Takayanagui, OM; Covas, DT; Kashima, S. HTLV-1 infects human mesenchymal stromal cell in vitro and modifies their phenotypic characteristics. Virology (New York, N.Y. Print), v. 449, p. 190-199, 2014.
6. Perlingeiro Beltrame, M; Malvezzi, M; Bonfim, C; Covas, DT; Orfao, A; Pasquini, R. Immune reconstitution in patients with Fanconi anemia after allogeneic bone marrow transplantation. Cytotherapy (Oxford), v. 1, p. 1, 2014.
7. Malta, TM; Silva, IT; Pinheiro, DG; Santos, ARD; Pinto, MT; Panepucci, RA; Takayanagui, OM; Tanaka, Y; Covas, DT; Kashima, S. Altered Expression of Degranulation-Related Genes in CD8 + T Cells in Human T Lymphotropic Virus Type I Infection. AIDS Research and Human Retroviruses, v. 29, p. 826-836, 2013.
8. Santis, GCD; Ubiali, EMA; Covas, DT. Compassionate use of cell products. Revista Brasileira de Hematologia e Hemoterapia (Impresso), v. 35, p. 144, 2013.
9. Oliveira, FM; Araujo, ARL; Favarin, MDC; Palma, PVB; Rego, EM; Falcão, RP; Covas, DT; Fontes, AM. Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodisplastic syndrome: Correlation with G-banding analysis and FISH. Experimental Hematology, v. 41, p. 198-208, 2013.
10. Mizukami, A; Orellana, MD; Caruso, SR; De Lima Prata, K; Covas, DT; Swiech, K. Efficient expansion of mesenchymal stromal cells in a disposable fixed bed culture system. Biotechnology Progress (Print), v. 29, p. 568-572, 2013.
11. Palma, C; Tannous, M; Malta, T; Carbolante, ES; Covas, DT; Picanço-Castro, V. Forced expression of OCT4 influences the expression of pluripotent genes in human mesenchymal stem cells and fibroblasts.. Genetics and Molecular Research, v. 2, p. 1054-1060, 2013.
12. Pinto, MT; Malta, TM; Rodrigues, ES; Pinheiro, DG; Panepucci, RA; Panepucci, RA; Farias, KCRMD; De Paula Alves Sousa, A; Takayanagui, OM; Tanaka, Y; Covas, DT; Kashima, S. Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4+ T cells in HAM/TSP patients.. AIDS Research and Human Retroviruses, v. 29, p. 130917035218000, 2013.
13. Brunetta, DM; De Santis, GC; Vilar, FC; Vilar, FC; Brandão, RA; Muniz, RZDA; De Lima, GMN; Amorelli-Chacel, ME; Covas, DT; Machado, AA. Hematological particularities and co-infections in injected drug users with AIDS. The Brazilian Journal of Infectious Diseases (Impresso), v. 13, p. S1413-8670(13)0, 2013.
14. Slavov, SN; Kashima, S; Silva-Pinto, AC; Amarilla, AA; Aquino, VH; Covas, DT. Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature. The Brazilian Journal of Infectious Diseases (Impresso), v. 17, p. 97-101, 2013.
15. De Santis, GC; Brunetta, DM; Nardo, M; Oliveira, LC; Souza, FF; Cagnolati, D; Mente, ÊD; Sankarankutty, AK; Covas, DT; De Castro E Silva, O. Preoperative variables associated with transfusion requirements in orthotopic liver transplantation. Transfusion and Apheresis Science, v. 1, p. 1, 2013.
16. Del Lama, LS; De Góes, EG; Petchevist, PCD; Moretto, EL; Borges, JC; Covas, DT; De Almeida, A. Prevention of Transfusion-Associated Graft-versus-Host Disease by Irradiation: Technical Aspect of a New Ferrous Sulphate Dosimetric System. Plos One, v. 8, p. e65334, 2013.
17. Rodrigues, ES; Kashima, S; Picanço-Castro, V; Espanhol, MR; De Andrade, LA; Palma, PV; Kashima, S; Fontes, AM; Covas, DT. Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line. SpringerPlus, v. 2, p. 328, 2013.
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