Source: https://womab.com.ua/smb-2016-01/5842
Timestamp: 2019-04-23 02:42:26+00:00

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Аннотация Обзор посвящен биологической роли фолиевой кислоты и её производных в репродуктивной функции женщины. Акцентировано внимание на влияние дефицита фолиевой кислоты в формировании гипергомоцистеинемии и эндотелиальной дисфункции у больных с синдромом поликистозных яичников, приводятся результаты собственных наблюдений. Авторами установлено, что у пациенток с СПКЯ имеется дефицит фолиевой кислоты различной степени выраженности и повышено содержание эндотелина-1. Выявлена отрицательная корреляционная связь между содержанием фолиевой кислоты и концентрацией гомоцистеина в плазме. Указано на необходимость определения уровня фолиевой кислоты с целью своевременного проведения мероприятий направленных на профилактику развития эндотелиальной дисункции.
Grodnitskaya E. E. Rol narusheniy v obmene folatov i gomotsisteina v razvitii oslozhneniy beremennosti / E. E. Grodnitskaya // Rossiyskiy vestnik akushera ginekologa. – 2010. –No. 4. – S.20 – 24.
Dobrohotova Yu. E. Znachenie folievoy kislotyi v akusherstve i perinatologii / Yu. E. Dobrohotova, E. M. Dzhobava, L. H. Heydar [i dr.] // Problemyi reproduktsii. – 2006. – T. 12, No. 1. – S. 98 – 101.
Zhukova V. B. Gipergomotsisteyinemiya: stan problemi / V. B. Zhukova, Yu. V. Protas, K. Yu. Gnidenko [ta In.] // Suchasna gastroenterologiya. – 2006. – No. 1. – S. 87 – 92.
Kurtser M. A. Folievaya kislota v realizatsii reproduktivnoy funktsii: metod. Rekomendatsii / Departament zdravoohraneniya Moskvyi // M. A. Kurtser, E. E. Grodnitskaya // – M., -2011. – 23 s.
Kerkeshko G. O. Optimizatsiya terapii folatami pri oslozhneniyah beremennosti / G. O. Kerkeshko, A. V. Arutyunyan, O. N. Arzhanova [i dr.] // Zhurnal akusherstva i zhenskih bolezney. – 2013. – Tom 62, No. 6. – S. 25 – 36.
Kuznetsova I. V. Folievaya kislota i ee rol v zhenskoy reproduktsii / I. V. Kuznetsova, V. A. Kononova // Ginekologiya. – 2014. – No. 4. – S. 17 – 23.
Muhin N. A. Giper gomotsisteinemiya kak faktor riska razvitiya zabolevaniy serdechnoy-sosudistoy sistemyi / N. A. Muhin, S. V. Moiseev, V. V. Fomin // Klinicheskaya meditsina. – 2001. – No. 6. – S. 7 –14.
Makatsariya A. D. Gipergomotsisteinemiya i oslozhneniya beremennosti / A. D. Makatsariya, E. V. Beloborodova, S. M. Baymuradova [i dr.] // – M.: Triada-H, -2005.– 41 s.
Naumov A. V. Rol narusheniy protsessov metilirovaniya i obmena metionina v patogeneze zabolevaniy cheloveka / A. V. Naumov // Zhurnal GrGMU. – 2007. – T. 17, No. 1. – S. 4 – 7.
Reznikov A. G. Rol aktivnyih soedineniy folievoy kislotyi pri ispolzovanii kombinirovannyih oralnyih kontratseptivov / A. G. Reznikov // Reproduktivnaya endokrinologiya. – 2012. – T. 2, No. 4. – S. 48 – 51.
Toguzov R. T. Soderzhanie folatov i lipoevoy kislotyi v gepatoprotektore Progepar / R. T. Toguzov, E. S. Mamedov, E. N. Shachnev [i dr.] // Farmateka. – 2010. – T. 205, No. 11. – S. 77 – 82.
Trifanova E. A. Gomotsistein, polimorfizm gena MTHFR i oslozhneniya beremennosti / E. A. Trifanova, T. V. Gabidulina, G. A. Agarkovo [i dr.] // Akusherstvo i ginekologiya. – 2011. – No. 2. – S. 8 – 15.
Tapilskaya N.I. Ustranenie defitsita folatov-osnovnaya strategiya korrektsii gomotsisteinzavisimoy endotelialnoy disfunktsii / N. I. Tapilskaya, S.N. Aydukov // Ginekologiya. – 2013. – No. 3. – S. 70 – 74.
Angier R. B. Synthesis of a compound identical with the L. casei Factor isolated from liver/ R. B. Angier, J. H. Boothe, B. L. Hutchings [et al.] // Science. – 1945. – Vol. 102, № 2644. – P. 227– 228.
Brown A. S. Elevated prenatal homo-cysteine levels as a risk factor for schizophrenia / A. S. Brown, Т. Bottiglieri, C. A. Schaefer [et al.] // Arch. Gen. Psychiat. – 2007. – Vol. 64, № 1. – Р. 31 – 39.
Bailey S. W. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acidi intake / S. W. Bailey, J. E. Ayling // Proc. Nat. Acad. Sci. USA. – 2009. – Vol. 106, № 36. – Р. 15424 – 15429.
Bahmani F. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial / F. Bahmani, M. Karamali, H. Shakeri [et al.] // Clin. Endocrinol. (Oxf). –2014. – Vol. 81, № 4. – Р. 582 – 587.
Calle M. Increased homocysteine levels in polycystic ovary syndrome / M. Calle, T. Gallardo, M. D. Diestro [et al.] // Med. Clin. (Barc). – 2007. – Vol. 129, № 8. –Р. 292 – 294.
Caserta D. Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping / D. Caserta, G. Adducchio, S. Picchia [et al.] // Gynecol. Endocrinol. – 2014. –Vol. 30, № 6. – Р. 397 – 402.
Dose-dependent effects of folic acid on blood concentrations of homocysteine:a meta-analysis of the randomized trials / Homocysteine Lowering Trialists’ Collaboration. // Am. J. Clin. Nutr. – 2005. – Vol. 82, № 4. – Р. 806 – 812.
Dubey P. Hyperhomocysteinemia: a risk factor in unexplained infertility / P. Dubey, N. Gupta, S. Dwivedi [et al.] // Inter. J. Reprod. Contracept. Obstet. Gynecol. – 2013. – Vol. 2, № 2. – Р. 165 – 171.
Daan N. M. Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk ? / N. M. Daan, Y. V. Louwers, M. P. Koster [et al.] // Fertil Steril.– 2014. – Vol. 102, № 5. – Р. 1444 –1451.
Finkelstein J. D. Methionin metabolism in mammals / J. D. Finkelstein // J. Nutr. Biochem. – 1990. – Vol. 1. – P. 228 – 237.
Fowler B. Disorder of homocysteine metabolism / B. Fowler // J. Inter. Metab. – 1997. – Vol. 20, № 2. – P. 270 – 285.
Fawler B. The Follate cycle and Disease in humans / В. Fawler // Kidney Int. – 2001. – Vol. 59, № 78. – Р. 221 – 229.
Fowler B. Homocysteine: overwiew of biochenistry, molecular biology, and role in disease processes / B. Fowler // Semin. Vasc. Med. – 2005. – Vol. 5, № 2. – Р. 77 – 86.
Forges T. Impact of folate and homocysteine metabolism on human reproductive health / T. Forges, P. Monnier-Barbarino, J. Alberto [et al.] // Hum. Reprod. Update. – 2007. – Vol. 13, № 3. – Р. 225 – 238.
Forges T. Impact of folate and homocysteine metabolism on human reproductive health / T. Forges, P. Monnier-Barbarino, J. M. Alberto [et al.] // Hum. Reprod. – 2007. – Vol. 13, № 3. – Р. 225 – 238.
Forges T. Do folate have an implact of fertility / T. Forges, H. Pellanda, C. Diligent [et al.] // Gynecol. Obstet. Fertil. – 2008. – Vol. 36, № 9. – Р. 930 – 939.
Gaskins A. J. Dietary folate and reproductive success among women undergoing assisted reproduction / A. J. Gaskins, M. C. Afeiche, D. L. Wright [et al.] // Obstet. Gynecol. –2014. – Vol. 124, № 4. – Р. 801 – 809.
Harmon D. L. The common "thermolabile" variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinemia / D. L. Harmon, J. V. Woodside, J.W. Yarnell [et al.] // Q. J. Med. – 1996. – Vol. 89, № 8. – Р. 571 – 577.
Khaodhiar L. Obesity and comorbid conditions / L. Khaodhiar, K. C. Mc Cowen, G. L. Blackburn // Clin. Cornerstone. – 1999. – Vol. 2, № 1. – Р. 17 – 31.
Kao Y. H. Endothelial progenitor cell dysfunction in polycystic ovary syndrome: implications for the genesis cardiovascular diseases genesis / Y. H. Kao, W. C. Chin, M. I. Hsu Samani [et al.] // Int. J. Fertil. Steril. – 2013. – Vol. 6, № 4. Р. 2008 – 2013.
Lindenbaum J. Oral contraceptive hormones, folate metabolism,and the cervical epithelium / J. Lindenbaum, N. Whitehead, F. Reyner // Am. J. Clin. Nutr. – 1975. – Vol. 28, № 4. – Р. 346 –353.
Loverro G. The plasma homocysteine levels are increased in polycystic ovary syndrome / G. Loverro, F. Lorusso, L. Mei [et al.] // Gynecol. Obstet. Invest. – 2002. – Vol. 53, № 3. – Р. 157 – 162.
Lavie L. Daily rhythms in plasma levels of homocysteine / L. Lavie // J. Circadian. Rhythms. – 2004. – Vol. 3. – P. 25 – 29.
Lim S. S. The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis / S. S. Lim, R. J. Norman, M. J. Davies [et al.] // Obes. Rev. – 2013. – Vol. 14, № 2.– Р. 95 – 109.
Mohanty D. Effect of folate deficiency on the reproductive organs of female rhesus monkeys: a cytomorphological and cytokinetic study / D. Mohanty, K. C. DAS // J. Nutr. – 1982. – Vol. 112, № 8. – Р. 1565 – 1576.
MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study // Lancet. – 1991. – Vol. 338, № 8760. – P. 131– 137.
Medina M. Roles of homocysteine in cell metabolism: old and new functions / M. Medina // Eur. J. Biochem. – 2001. – Vol. 286.– P. 3871 – 3882.
Moat S. J. Folate, homocysteine, endothelial function and cardiovascular disease / S. J. Moat, D. Lang, I. F. Mc Dowell [et al.] // J. Nutr. Biochem. – 2004. – Vol. 15, № 2. – Р 64 – 79.
Maleedhu Р. Status of Homocysteine in Polycystic Ovary Syndrome (PCOS) / P. Maleedhu, P. K. Kodumuri, D. V. Devi // J. Clin. Diagn. Res. – 2014. – Vol. 8, № 2. – Р. 32 – 33.
Nafiye Y. The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization out come / Y. Nafiye, K. Sevtap, D. Muammer [et al.] // Fertil. Steril. – 2010. – Vol. 93, № 6. – Р. 1864 – 1869.
Orio F. Early impairment of endothelial structure and function in young normal- weight women with polycystic ovary syndrome / F. Orio, S. Palomba, T. Cascella // J. Clin. Endоcrinol. Metabol. – 2004. – Vol. 89, № 9. – Р. 4588 – 4593.
Pietrzik K. Folic acid and L-5-methyltetrahydrofo late: comparison of clinical pharmacokinetics and pharmacodynamics / K. Pietrzik, L. Bailey, B. Shane // Clin. Pharmacokinet. – 2010. – Vol. 49, № 8. – Р. 535 – 548.
Qiao J. Extra-and intra- ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence / J. Qiao, H. L. Fend // Hum. Reprod. Updata. – 2011. – Vol. 17, № 1. – Р. 17 – 33.
Selhub J. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population / J. Selhub, P. F. Jacques, P. W. Wilson [et al.] // JAMA. – 1993. – Vol. 270, № 2. – P. 2693 – 2698.
Sills E. S. Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility / E. S. Sills, M. G. Genton, M. Perloe [et al.] // Obstet. Gynaecol. Res. – 2001. – Vol. 27, № 3. – Р. 163 –168.
Salehpour S. Evaluation of homocysteine levels in patients with polycystic ovarian syndrome / S. Salehpour, О. Manzor-Al-Ajdad, E. N. Samani [et al.] // Int. J. Fertil. Steril. – 2011. – Vol. 4, № 4. – Р. 168 –171.
Salehpour S. Evaluation of homocysteine levels in patients with polycystic ovary syndrome / S. Salehpour, O. Manzor-al-ajdad, E. Neisani Samani [et al.] // Int. J. Fertil. Steril. – 2011. – Vol. 4, № 4. – Р. 168 – 171.
Schachter M. Insulin resistence in patient with polycystic ovary syndrome is associated with elevated plasma homocysteine / M. Schachter, A. Raziel, S. Friedler [et al.] // Hum. Reprod. – 2003. – Vol. 18, № 4. – Р. 721 – 727.
Sohrabvand F. Serum homocystein levels in PCOS patients versus healthy women / F. Sohrabvand, M. Lankarani, B. Golestan [et al.] // J. Reprod. Infertility. – 2009. – 9, № 37. – Р. 334 – 341.
Simpson J. L. Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess / J. L. Simpson, L. B. Bailey, K. Pietrzik [et al.] // J. Matern. Fetal. Neonatal. Med. – 2010. – Vol. 23, № 12. – Р. 1323 – 1343.
Tsanadis G. Polycystic ovarian syndrome and thrombophilia / G. Tsanadis, G. Vartholomatos, I. Korkontzelos [et al.] // Hum. Reprod. – 2002. – Vol. 17, № 2. – Р. 314 – 319.
The Rotterdam ESHRE/ ASRM- sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteriaand long-term health risks related to polycystic ovary syndrome (PCOS) // Hum. Reprod. – 2004. – Vol. 19, № 1. – P. 41 – 47.
Tamura T. Folate and human reproduction / T. Tamura, M. F. Pacciano // Am.J. Clin. Nutr. – 2006. – Vol. 83, № 5. – Р. 933 – 1016.
Vanaerts L. A. Prevention of neural tube defects by and toxicity of L?homocysteine in cultured postimplantation rat embryos / L. A. Vanaerts, H. J. Blom, R. A. Deabreu [et al.] // Teratology. – 1994. – Vol. 50, № 5. – P. 348 – 360.
van der Put N. M. Folate, homocysteine and neural tube defects: an overview /, H. W. van Straaten [et al.] // Exp. Biol. Med. – 2001 – Vol. 226, № 4. – P. 243 – 270.
Van Bejnum, I. M. Total homocysteine and its predictors in Dutch children / I. M. van Bejnum // Am. J. Clin. Nutr. – 2005. – Vol. 81. – P. 1110 – 1116.
Willmott M. The effect of folicacid on superovulation in the immature rat / M. Willmott, D. B. Bartosik , E. B. Romanoff // J. Endocrinol. – 1986. – Vol. 43, № 3. – 439 – 445.
Wani N. A. Folate status in various pathophysiological conditions / N. A. Wani, A. Hamid, J. Kaur // IUBMB Life. – 2008. – Vol. 60, № 12 – P. 834 – 842.
Yilmaz M. Levels of lipoprotein and homocystein in non-obese and obese patients with polycystic ovary syndrome / M. Yilmaz, A. Biri, N. Bukan [et al.] // Gynecol. Endocrinol. – 2005. – Vol.20, № 5. – Р. 258 – 263.

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