Source: https://people.epfl.ch/diego.ghezzi
Timestamp: 2019-04-26 04:14:35+00:00

Document:
Prof. Diego Ghezzi holds the Medtronic Chair in Neuroengineering at the School of Engineering at the Ecole Polytechnique Fédérale de Lausanne. He received his M.Sc. in Biomedical Engineering (2004) and Ph.D. in Bioengineering (2008) from Politecnico di Milano. From 2008 to 2013, he completed his postdoctoral training at Istituto Italiano di Tecnologia in Genova at the Department of Neuroscience and Brain Technologies; where he was promoted to Researcher in 2013. In 2015, he was appointed as Tenure-Track Assistant Professor of Bioengineering at the EPFL Center for Neuroprosthetics and Institute of Bioengineering.
Our laboratory is a multidisciplinary environment promoting cross-fertilization among various expertise. We bring materials science, engineering, life science, and medicine together by the convergence of physicists, engineers, neuroscientists, and ophthalmologists cooperating to accomplish innovative projects. Our mission is the development of application-driven solutions based on compliant, minimally invasive, and replaceable neuroprosthetic devices. Ultimately, we aim at translating our research findings into clinical practice.
E. Cuttaz; J. Goding; C. Vallejo-Giraldo; U. Aregueta-Robles; N. Lovell et al. : Conductive elastomer composites for fully polymeric, flexible bioelectronics; Biomaterials Science. 2019-01-16. DOI : 10.1039/C8BM01235K.
S. Gribi; S. du Bois de Dunilac; D. Ghezzi; S. P. Lacour : A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers; Nature Communications. 2018-10-23. Vol. 9, num. 1, p. 4403. DOI : 10.1038/s41467-018-06895-7.
L. Ferlauto; A. N. D’Angelo; P. Vagni; M. J. I. Airaghi Leccardi; F. M. Mor et al. : Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics; Frontiers in Neuroscience. 2018-09-19. Vol. 12. DOI : 10.3389/fnins.2018.00648.
M. J. I. Airaghi Leccardi; P. Vagni; D. Ghezzi : Multilayer 3D electrodes for neural implants; Journal of Neural Engineering. 2018-09-14. Vol. 16, num. 2, p. 1-12, 026013. DOI : 10.1088/1741-2552/aae191.
V. Gaillet; A. Cutrone; P. Vagni; F. Artoni; S. A. Romero Pinto et al. : Optic nerve intraneural stimulation allows selective visual cortex activation. 2018-05-07. DOI : 10.1101/311035.
K. Meng; A. Fellner; F. Rattay; D. Ghezzi; H. Meffin et al. : Upper stimulation threshold for retinal ganglion cell activation; Journal of Neural Engineering. 2018-04-05. Vol. 15, num. 4. DOI : 10.1088/1741-2552/aabb7d.
L. Ferlauto; M. J. I. Airaghi Leccardi; N. A. L. Chenais; S. C. A. Gilliéron; P. Vagni et al. : Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis; Nature Communications. 2018-03-08. Vol. 9, num. 1, p. 992. DOI : 10.1038/s41467-018-03386-7.
M. Parrini; D. Ghezzi; G. Deidda; L. Medrihan; E. Castroflorio et al. : Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome; Scientific Reports. 2017. Vol. 7, num. 1. DOI : 10.1038/s41598-017-17201-8.
J. F. Maya-Vetencourt; D. Ghezzi; M. R. Antognazza; E. Colombo; M. Mete et al. : A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness; Nature Materials. 2017. DOI : 10.1038/nmat4874.
M. R. Antognazza; M. Di Paolo; D. Ghezzi; M. Mete; S. Di Marco et al. : Characterization of a Polymer-Based, Fully Organic Prosthesis for Implantation into the Subretinal Space of the Rat; Advanced Healthcare Materials. 2016. Vol. 5, num. 17, p. 2271-2282. DOI : 10.1002/adhm.201600318.
P. Feyen; E. Colombo; D. Endeman; M. Nova; L. Laudato et al. : Light-evoked hyperpolarization and silencing of neurons by conjugated polymers; Scientific Reports. 2016. Vol. 6, p. 22718. DOI : 10.1038/srep22718.
J. Szczurkowska; A. W. Cwetsch; M. Dal Maschio; D. Ghezzi; G. M. Ratto et al. : Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe; Nature Protocols. 2016. Vol. 11, num. 3, p. 399-412. DOI : 10.1038/nprot.2016.014.
M. Di Paolo; D. Ghezzi; M. R. Antognazza; M. Mete; G. Freddi et al. : Inflammatory and morphological characterisation of a foreign body retinal response; European Journal of Neurodegenerative Diseases. 2015. Vol. 4, num. 1, p. 23-28.
N. Martino; P. Feyen; M. Porro; C. Bossio; E. Zucchetti et al. : Photothermal cellular stimulation in functional bio-polymer interfaces; Scientific Reports. 2015. Vol. 5, p. 8911. DOI : 10.1038/srep08911.
J. Szczurkowska; A. W. Cwetsch; M. Dal Maschio; D. Ghezzi; G. M. Ratto et al. : High-performance and reliable site-directed in vivo genetic manipulation of mouse and rat brain by in utero electroporation with a triple-electrode probe; Protocol Exchange. 2013. DOI : 10.1038/protex.2013.089.
A. Contestabile; B. Greco; D. Ghezzi; V. Tucci; F. Benfenati et al. : Lithium rescues synaptic plasticity and memory in Down syndrome mice; Journal of Clinical Investigation. 2013. Vol. 123, num. 1, p. 348-361. DOI : 10.1172/JCI64650.
D. Ghezzi; M. R. Antognazza; R. Maccarone; S. Bellani; E. Lanzarini et al. : A polymer optoelectronic interface restores light sensitivity in blind rat retinas; Nature Photonics. 2013. Vol. 7, num. 5, p. 400-406. DOI : 10.1038/nphoton.2013.34.
E. Biffi; G. Regalia; D. Ghezzi; R. De Ceglia; A. Menegon et al. : A novel environmental chamber for neuronal network multisite recordings; Biotechnology and Bioengineering. 2012. Vol. 109, num. 10, p. 2553-2566. DOI : 10.1002/bit.24526.
M. Dal Maschio; D. Ghezzi; G. Bony; A. Alabastri; G. Deidda et al. : High-performance and site-directed in utero electroporation by a triple-electrode probe; Nature Communications. 2012. Vol. 3, p. 960. DOI : 10.1038/ncomms1961.
E. Ferrea; A. Maccione; L. Medrihan; T. Nieus; D. Ghezzi et al. : Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays; Frontiers in Neural Circuits. 2012. Vol. 6. DOI : 10.3389/fncir.2012.00080.
G. Iurilli; D. Ghezzi; U. Olcese; G. Lassi; C. Nazzaro et al. : Sound-Driven Synaptic Inhibition in Primary Visual Cortex; Neuron. 2012. Vol. 73, num. 4, p. 814-828. DOI : 10.1016/j.neuron.2011.12.026.
D. Ghezzi; M. R. Antognazza; M. Dal Maschio; E. Lanzarini; F. Benfenati et al. : A hybrid bioorganic interface for neuronal photoactivation; Nature Communications. 2011. Vol. 2, p. 166. DOI : 10.1038/ncomms1164.
E. Biffi; D. Ghezzi; A. Pedrocchi; G. Ferrigno : Development and Validation of a Spike Detection and Classification Algorithm Aimed at Implementation on Hardware Devices; Computational Intelligence and Neuroscience. 2010. Vol. 2010, p. 1-15. DOI : 10.1155/2010/659050.
M. R. Antognazza; D. Ghezzi; D. Musitelli; M. Garbugli; G. Lanzani : A hybrid solid-liquid polymer photodiode for the bioenvironment; Applied Physics Letters. 2009. Vol. 94, num. 24, p. 243501. DOI : 10.1063/1.3153846.
D. Ghezzi; R. M. Vazquez; R. Osellame; F. Valtorta; A. Pedrocchi et al. : Femtosecond Laser Microfabrication of an Integrated Device for Optical Release and Sensing of Bioactive Compounds; Sensors. 2008. Vol. 8, num. 10, p. 6595-6604. DOI : 10.3390/s8106595.
D. Ghezzi; A. Menegon; A. Pedrocchi; F. Valtorta; G. Ferrigno : A Micro-Electrode Array device coupled to a laser-based system for the local stimulation of neurons by optical release of glutamate; Journal of Neuroscience Methods. 2008. Vol. 175, num. 1, p. 70-78. DOI : 10.1016/j.jneumeth.2008.08.003.
D. Ghezzi; A. Pedrocchi; A. Menegon; S. Mantero; F. Valtorta et al. : PhotoMEA: An opto-electronic biosensor for monitoring in vitro neuronal network activity; Biosystems. 2007. Vol. 87, num. 2-3, p. 150-155. DOI : 10.1016/j.biosystems.2006.09.008.
G. Lanzani; M. R. Antognazza; N. Martino; D. Ghezzi; F. Benfenati : Controlling cell functions by light ; 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER). 2015. 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER), Montpellier, France, 22-24 April 2015. p. 603-606. DOI : 10.1109/NER.2015.7146695.
D. Ghezzi; A. Menegon; A. Pedrocchi; S. Mantero; F. Valtorta et al. : PhotoMEA: A New Step Towards Total Optical Analysis of In Vitro Neuronal Networks ; ASME 8th Biennial Conference on Engineering Systems Design and Analysis. 2006. ASME 8th Biennial Conference on Engineering Systems Design and Analysis (ESDA), Torino, Italy, July 4–7, 2006. p. 441-449. DOI : 10.1115/ESDA2006-95218.
D. Ghezzi; A. Pedrocchi; A. Menegon; S. Mantero; F. Valtorta et al. : PhotoMEA: An opto-electronic biosensor for monitoring in vitro neuronal networks activity ; Proceedings of the Sixth International Workshop on Information Processing in Cells and Tissues. 2005. Sixth International Workshop on Information Processing in Cells and Tissues (IPCAT), St William’s College, York, United Kingdom, August 30 - September 1, 2005. p. 108-118.
D. Ghezzi : Retinal prostheses: progress toward the next generation implants; Frontiers in Neuroscience. 2015. Vol. 9. DOI : 10.3389/fnins.2015.00290.
M. R. Antognazza; N. Martino; D. Ghezzi; P. Feyen; E. Colombo et al. : Shedding Light on Living Cells; Advanced Materials. 2014. p. n/a-n/a. DOI : 10.1002/adma.201403513.
N. Martino; D. Ghezzi; F. Benfenati; G. Lanzani; M. R. Antognazza : Organic semiconductors for artificial vision; Journal of Materials Chemistry B. 2013. Vol. 1, num. 31, p. 3768. DOI : 10.1039/c3tb20213e.
M. R. Antognazza; M. Porro; D. Ghezzi; F. Benfenati; G. Lanzani : Emerging Technologies in Retinal Prosthetics; Integrated Multidisciplinary Approaches in the Study and Care of the Human Eye; Kugler Publications, 2014.
D. Endeman; P. Feyen; D. Ghezzi; M. R. Antognazza; N. Martino et al. : The Use of Light-Sensitive Organic Semiconductors to Manipulate Neuronal Activity; Novel Approaches for Single Molecule Activation and Detection; Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. p. 189-202.
D. Ghezzi : Coupling MEA Recordings and Optical Stimulation: New Optoelectronic Biosensors; Optoelectronics - Devices and Applications; InTech, 2011.
A. Fanelli; L. Ferlauto; D. Ghezzi : Bioresorbable Endovascular Neural Interface for Minimally Invasive Neural Stimulation and Recording ; NanoBioTech-Montreux 2028, Montreux, Switzerland , October 29-31, 2018.
E. Borda; M. J. I. Airaghi Leccardi; D. Ghezzi : Soft Three-dimensional self-opening intraneural peripheral interface for optic nerve stimulation ; NanoBioTech-Montreux 2018, Montreux, Switzerland , October 29-31, 2018.
A. Contestabile; M. Parrini; D. Ghezzi; G. Deidda; M. Alberti et al. : Neurotrophic-mimetic strategy to rescue synaptic plasticity and cognitive functions in a mouse model of Down syndrome ; 11th Forum of European NeuroScience (FENS), Berlin, Germany, July 7-11 2018.
P. Vagni; T. Marchetti; L. Perlini; A. Contestabile; L. Cancedda et al. : Preservation of visual function in an animal model of retinal degeneration using CRISPR/Cas9 gene editing ; 11th Forum of European NeuroScience (FENS), Berlin, Germany, July 7-11 2018.
N. Chenais; M. J. I. Airaghi Leccardi; L. Ferlauto; D. Ghezzi : A comprehensive study of neural retina stimulation towards better visual prosthesis resolution ; 11th Forum of European NeuroScience (FENS), Berlin, Germany., July 7-11 2018.
V. Gaillet; A. Cutrone; P. Vagni; F. Artoni; S. Gilliéron et al. : In vivo electrical stimulation of the optic nerve and hybrid computational model for neuroprosthetic applications ; 11th Forum of European NeuroScience (FENS), Berlin, Germany, July 7-11 2018.
A. Contestabile; M. Parrini; M. Alberti; D. Ghezzi; G. Deidda et al. : Neurotrophic-mimetic strategy to rescue synaptic plasticity and cognitive functions in a mouse model of Down syndrome ; Neuroscience 2017 (SFN), Washington, District of Columbia, USA, November 11-15, 2017.
J. F. Maya-Vetencourt; D. Ghezzi; M. R. Antognazza; E. Colombo; M. Mete et al. : A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness ; Neuroscience 2017 (SFN), Washington, District of Columbia, USA, November 11-15, 2017.
N. Chenais; M. J. I. Airaghi Leccardi; L. Ferlauto; K. Sivula; D. Ghezzi : Photovoltaic stimulation of retinal ganglion cells with wide-field epiretinal prosthesis ; The European Retina Meeting 2017, Paris, France, October 5-7, 2017.
L. Ferlauto; A. N. D'Angelo; D. Ghezzi : Edible Neuroprosthetics ; 18th CMi Annual Review Meeting, EPFL, Lausanne, Switzerland, May 2, 2017.
M. J. I. Airaghi Leccardi; L. Ferlauto; D. Ghezzi : Fabrication of visual prostheses ; 18th CMi Annual Review Meeting, EPFL, Lausanne, Switzerland, May 2, 2017.
L. Ferlauto; P. Vagni; D. Ghezzi : Transient electronics for edible neuroprosthetics ; 13th International Conference on Organic Electronics (ICOE), St. Petersburg, Russia, June 4-8, 2017.
M. J. I. Airaghi Leccardi; L. Ferlauto; K. Sivula; D. Ghezzi : Injectable, self-opening, and freestanding retinal prosthesis for fighting blindness made of conjugated polymers ; 2017 E-MRS Spring Meeting, Strasbourg, France, May 22-26, 2017.
M. J. I. Airaghi Leccardi; V. Gaillet; B. Duckert; D. Ghezzi : 3D multi-layer probe for application in neuroprosthetics ; 2017 E-MRS Spring Meeting, Strasbourg, France, May 22-26, 2017.
D. Ghezzi; K. Sivula; M. J. I. Airaghi Leccardi; L. Ferlauto : Injectable, Self-opening, and Freestanding Retinal Prosthesis for Fighting Blindness ; The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Baltimore, Maryland, USA, May 7-11, 2017.
P. Vagni; L. E. Perlini; M. Parrini; A. Contestabile; L. Cancedda et al. : Gene editing in photoreceptor progenitors prevents visual function loss in a mouse model of retinal degeneration ; The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Baltimore, Maryland, USA, May 7-11, 2017.
M. J. I. Airaghi Leccardi; L. Ferlauto; M. Salari; D. Ghezzi : Injectable, Self-opening, and Freestanding Retinal Prosthesis for Fighting Blindness ; NanoBioTech-Montreux, Montreux, Switzerland, November 7-9, 2016.
L. Ferlauto; M. J. I. Airaghi Leccardi; P. Vagni; D. Ghezzi : When Polymeric Materials meet Neuroengineering ; Bioengineering Day, Geneva, Switzerland, September 28, 2016.
P. Vagni; L. E. Perlini; D. Ghezzi : Electroporation for the delivery of gene therapy in the retina ; Bioengineering Day, Geneva, Switzerland, September 28, 2016.
M. J. I. Airaghi Leccardi; L. Ferlauto; D. Ghezzi : Injectable, self-opening, and freestanding retinal prosthesis ; 17th CMi Annual Review Meeting, EPFL, Lausanne, Switzerland, May 3, 2016.
M. J. I. Airaghi Leccardi; L. Ferlauto; P. Vagni; D. Ghezzi : Injectable, self-opening, and freestanding retinal prosthesis for fighting blindness ; 2016 CNP Annual Retreat, Chamonix Mont Blanc, France, January 25-26, 2016.
E. Colombo; P. Feyen; D. Endeman; M. Nova; M. R. Antognazza et al. : Light-Evoked Modulation of Neuronal Activity with Conjugated Polymers ; 7th International IEEE/EMBS Conference on Neural Engineering (NER), Montpellier, France, April 22-24, 2015.
M. Parrini; D. Ghezzi; G. Deidda; L. Medrihan; F. Benfenati et al. : Physical exercise rescues adult neurogenesis, synaptic plasticity and memory in down syndrome mice ; 9th FENS Forum of Neuroscience, Milano, Italy, July 5-9, 2014.
D. Ghezzi; M. R. Antognazza; M. Mete; G. Pertile; G. Lanzani et al. : A polymer-based interface restores light sensitivity in rat blind retinas ; Neuroscience 2013 (SFN), San Diego, California, USA, October 9-13, 2013.
M. Mete; G. Pertile; D. Ghezzi; M. R. Antognazza; R. Maccarone et al. : A polymer-based interface restores light sensitivity in rat blind retinas ; Annual Meeting of The Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington, USA, May 5-9, 2013.
A. Contestabile; B. Greco; V. Tucci; F. Benfenati; L. Gasparini : A Role For Adult Neurogenesis In Dentate Synaptic Plasticity Deficits And Memory Impairment In Down Syndrome ; 8th Forum of European NeuroScience (FENS), Barcelona, Spain, July 14-18, 2012.
M. Dal Maschio; D. Ghezzi; G. Bony; A. Alabastri; G. Deidda et al. : High-performance and site-directed in utero electroporation by a triple-electrode probe ; Neuroscience 2012 (SFN), New Orleans, Louisiana, USA, October 13-17, 2012.
A. Contestabile; B. Greco; D. Ghezzi; V. Tucci; F. Benfenati et al. : A role for adult neurogenesis in dentate synaptic plasticity deficits and memory impairment in Down syndrome ; Neuroscience 2012 (SFN), New Orleans, Louisiana, USA, October 13-17, 2012.
D. Ghezzi; E. Lanzarini; N. Martino; M. R. Antognazza; R. Maccarone et al. : Organic electronics allows the photo-electric excitation of neuronal activity in primary neuronal cultures and acute retinal explants ; Neuroscience 2012 (SFN), New Orleans, Louisiana, USA, October 13-17, 2012.
E. Ferrea; L. Medrihan; D. Ghezzi; T. Nieus; P. Baldelli et al. : Electrophysiological imaging of epileptic brain slices reveals pharmacologically confined functional changes ; 8th International Meeting on Substrate-Integrated Microelectrode Arrays (SIMEA), Reutlingen, Germany, July 10-13, 2012.
D. Ghezzi; E. Lanzarini; N. Martino; M. R. Antognazza; R. Maccarone et al. : Organic electronics allows the photo-electric excitation and inhibition of neuronal activity in primary neuronal cultures and acute retinal explants ; The 63rd National Congress of the Italian Physiological Society (SIF), Verona, Italy, September, 21-23, 2012.
D. Ghezzi; M. R. Antognazza; M. Dal Maschio; E. Lanzarini; G. Lanzani et al. : A hybrid bio-organic interface for neuronal photo-activation ; Nearoscience 2011 (SFN), Washington, District of Columbia, USA, November 12-16, 2011.
D. Ghezzi; M. Dal Maschio; G. Bony; G. Deidda; F. Benfenati et al. : The three-electrode device: A new frontier for the in utero electroporation ; Neuroscience 2011 (SFN), Washington, District of Columbia, USA, November 12-16, 2011.
E. Ferrea; L. Medrihan; A. Maccione; D. Ghezzi; P. Baldelli et al. : Validation of a high-density microelectrode array for acute brain slice recordings ; Neuroscience 2011 (SFN), Washington, District of Columbia, USA, November 12-16, 2011.
D. Ghezzi; M. R. Antognazza; M. Dal Maschio; E. Lanzarini; G. Lanzani et al. : A hybrid bio-organic interface for neuronal photoactivation ; 8th World Congress of Neuroscience (IBRO), Firenze, Italy, July 14-18, 2011.
E. Ferrea; L. Medrihan; A. Maccione; P. Baldelli; D. Ghezzi et al. : Validation of a high-density microelectrode array for acute brain slice recordings ; 8th World Congress of Neuroscience (IBRO), Firenze, Italy, July 14-18, 2011.
A. Contestabile; B. Greco; D. Ghezzi; V. Tucci; F. Benfenati et al. : Pro-neurogenesis therapy rescues hippocampal-mediated learning and memory deficits in the ts65dn mouse model of Down syndrome ; Neuroscience 2010 (SFN), San Diego, California, USA, October 13-17, 2010.
G. Iurilli; D. Ghezzi; G. Lassi; V. Tucci; F. Benfenati et al. : Sound-driven modulation of sub- and suprathreshold activity in mouse primary visual cortex ; Neuroscience 2010 (SFN), San Diego, California, USA, October 13-17, 2010.
M. Dal Maschio; D. Ghezzi; A. M. Verstegen; F. Benfenati : Targeted optogenetic stimulation to study the computational properties in neuronal ensembles recorded by multi-electrode devices ; 7th Forum of European NeuroScience (FENS), Amsterdam, The Netherlands, July 3-7, 2010.
A. Contestabile; B. Greco; D. Ghezzi; V. Tucci; F. Benfenati et al. : Neurogenesis as therapeutic target to rescue hippocampal-mediated learning and memory deficits in a mouse model of Down syndrome ; 7th Forum of European NeuroScience (FENS), Amsterdam, The Netherlands, July 3-7, 2010.
D. Boido; E. Ferrea; D. Ghezzi; P. Farisello; P. Baldelli et al. : Characterization of a mice model of human epilepsy with Multi-Electrode Arrays ; 7th International Meeting on Substrate-Integrated Micro Electrode Arrays (SIMEA), Reutlingen, Germany, June 29 - July 2, 2010.
M. R. Antognazza; E. Lanzarini; D. Ghezzi; M. Dal Maschio; F. Benfenati et al. : New Approaches towards Organic Photodetection and Bio-Integration ; 20th International Conference on Science and Technology of Synthetic Metals (ICSM), Kyoto, Japan, July 4-9, 2010.
M. R. Antognazza; E. Lanzarini; D. Ghezzi; M. Dal Maschio; F. Benfenati et al. : New Approaches towards Organic Photodetection and Bio-Integration ; 9th International Symposium on Functional pi-electron Systems (FPi9), Atlanta, Georgia, USA, May 23-28, 2010.
M. R. Antognazza; E. Lanzarini; D. Ghezzi; M. Dal Maschio; F. Benfenati et al. : New Approaches towards Organic Photodetection and Bio-Integration ; 2th International Hybrid and Organic Photovoltaics Conference (HOPV), Assisi, Italy, May 23-27, 2010.
E. Biffi; A. Pedrocchi; A. Menegon; D. Ghezzi; G. B. Fiore et al. : Prototype of a novel MEA bioreactor measuring neural network activity continuously over long periods ; The Monte Verità Workshop on the Frontiers in Neuroengineering, Ascona, Switzerland, September 5-9, 2010.
E. Biffi; D. Ghezzi; A. Pedrocchi; G. B. Fiore; G. Ferrigno : A novel mea bioreactor measuring neural network activity continuously over long periods to study synaptic plasticity and pharmacological outcomes ; Neuroscience 2009 (SFN), Chicago, Illinois, USA, October 17-21, 2009.
M. O. Heuschkel; D. Ghezzi; A. Menegon; A. Pedrocchi; S. Mantero et al. : The OptoMEA platform: a new tool combining local chemical stimulation with distributed multi-electrode array recordings ; 6th International Meeting on Substrate-Integrated Micro Electrode Arrays (SIMEA), Reutlingen, Germany, July 8-11, 2008.
E. Biffi; D. Ghezzi; A. Pedrocchi; G. Ferrigno : Spike detection algorithm improvement, spike waveforms projections with PCA and hierarchical classification ; 4th IET International Conference on Advances in Medical, Signal and Information Processing (MEDSIP 2008), Santa Margherita Ligure, Italy, July 14-16, 2008.
D. Ghezzi; A. Menegon; A. Pedrocchi; F. Benfenati; F. Valtorta et al. : Development of a new device to combine local optical stimulation and MEA recordings ; Primo Congresso Nazionale di Bioingegneria (GNB), Pisa, Italy, July 3-5, 2008.
D. Ghezzi; M. O. Heuschkel; A. Menegon; A. Pedrocchi; S. Mantero et al. : OptoMEA: a new tool for combining local optical activation of compounds with distributed MEA recordings ; Neuroscience 2007 (SFN), San Diego, California, USA, November 3-10, 2007.
E. Biffi; D. Ghezzi; F. Esposti; A. Menegon; M. G. Signorini et al. : A system for automatic on-line time detection and classification of neural spikes based on a digital signal processor and a FPGA controller ; Neuroscience 2007 (SFN), San Diego, California, USA, November 3-10, 2007.
D. Ghezzi; A. Pedrocchi; A. Menegon; S. Mantero; F. Valtorta et al. : PhotoMEA: A new optical biosensor for neuronal networks analysis ; EPFL LATSIS Symposium 2006, Lausanne, Switzerland, March 8-10, 2006.
D. Ghezzi : Organic technology for neuroprosthetic vision ; Invited Talk at Nature conference on flexible electronics, Xi’an, China, October 12-14, 2018.
D. Ghezzi : Organic technology for neuroprosthetic vision ; Invited talk at Asilomar Bioelectronics Symposium 2018, Pacific Grove, CA, USA, September 11-14, 2018.
D. Ghezzi : Towards an injectable retinal prothesis ; Invited talk at Montchoisi 3rd Annual Glaucoma Symposium, Lausanne, Switzerland, June 14, 2018.
D. Ghezzi : Organic neuroprosthetics for vision restoration ; Invited talk at Swiss Medtech Day 2018 - Organised by the Swiss Society for Biomedical Engineering , Bern, Switzerland, June 12, 2018.
D. Ghezzi : Validation of a Foldable and Photovoltaic Wide-Field Epiretinal Prosthesis ; Invited Talk at The 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2018), Singapore, April 22-26, 2018.
D. Ghezzi : Organic neuroprosthetics for vision restoration ; Invited talk at Swinburne University, Melbourne, Australia, February 9, 2018.
D. Ghezzi : Organic neuroprosthetics for vision restoration ; Invited Talk at Bionics Institute, Melbourne, Australia, Feb 9, 2018.
D. Ghezzi : Organic neuroprosthetics for vision restoration ; Invited talk at Institute de la vision, Paris, France, January 16, 2018 .
D. Ghezzi : MedPrint: Printed neural interfaces for neuroprosthetics ; Invited talk at Wyss investigator’s symposium, Geneva, Switzerland, December 4, 2017.
S. Gribi; M. Lamarre; D. Ghezzi; S. Lacour : A Nerve-on-a-Chip Platform to Facilitate the Design of Peripheral Nerve Interfaces ; 2017 MRS Spring Meeting, Phoenix, Arizona, April 17-21, 2017.
D. Ghezzi : Organic Neuroprosthetics For Vision Restoration ; Invited Talk at Swiss ePrint – The Swiss Conference on Printed Electronics and Functional Materials, Basel, Switzerland, September 26-27, 2017.
M. J. I. Airaghi Leccardi; L. Ferlauto; N. Chenais; M. Bevilacqua; T. J. Wolfensberger et al. : Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis ; 2017 Artificial Vision Meeting, Aachen, Germany, December 1-2, 2017.
L. Ferlauto; M. J. I. Airaghi Leccardi; N. Chenais; T. J. Wolfensberger; K. Sivula et al. : Design and validation of a foldable and photovoltaic wide-field retinal prosthesis ; 2017 MRS Fall Meeting, Boston, Massachusetts, USA, November 26-December 1, 2017.
L. Ferlauto; P. Vagni; D. Ghezzi : Edible neuroprosthetic devices ; 2017 MRS Fall Meeting, Boston, Massachusetts, USA, November 26-December 1, 2017.
P. Vagni; L. E. Perlini; M. Parrini; A. Contestabile; L. Cancedda et al. : Preventing visual function loss in the rd10 mouse model of retinitis pigmentosa using gene editing ; The European Retina Meeting 2017, Paris, France, October 5-7, 2017.
L. Ferlauto; M. J. I. Airaghi Leccardi; K. Sivula; D. Ghezzi : Injectable, self-opening, and freestanding retinal prosthesis for fighting blindness ; 13th International Conference on Organic Electronics (ICOE), St. Petersburg, Russia, June 4-8, 2017.
D. Ghezzi : Restoring sight with self-opening intraneural electrodes ; Invited talk at Wyss investigator’s symposium, Geneva, Switzerland, December 13, 2016.
D. Ghezzi : Organic Neuroprosthetics For Vision Restoration ; Invited Talk at Biosensors and Bioelectronics Congress, London, UK, November 17-18, 2016.
D. Ghezzi : Organic neuroprosthetics for vision restoration ; Invited Talk at Graphene NOWNANO Summer Conference, Cheshire, UK, June 27-30, 2016.
D. Ghezzi : Neuroprosthetics for vision restoration ; 17th CMi Annual Review Meeting, EPFL, Lausanne, CH, May 3, 2016.
M. R. Antognazza; N. Martino; S. Bellini; D. Ghezzi; P. Feyen et al. : Optical Control of Cell Functions by Conjugated Polymers ; 15th International Conference on Nanotechnology (IEEE NANO 2015), Rome, Italy, July 27-30, 2015.
D. Ghezzi : NeuroEngineering approaches applied to the restoration of sight ; Invited Talk at EPFL SV Faculty Retreat 2015, Vevey, Switzerland, February 9, 2015.
D. Ghezzi : Neuroengineering Approaches for Vision Restoration ; Bertarelli Symposium on Translational Neuroscience and Neuroengineering, Geneva, Switzerland, April 17, 2015.
D. Ghezzi : Neuroengineering approaches applied to the restoration of sight ; Invited Talk at San Raffaele Scientific Institute, Milano, Italy, May 11, 2015.
D. Ghezzi : Neuroengineering approaches applied to the restoration of sight ; Invited talk at Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland, May 13, 2015.
D. Ghezzi : Gene therapy and bioengineering for retinal diseases: what is the future? ; Invited Talk at 12th ISOPT Clinical, Berlin, Germany, July 9-12, 2015.
D. Ghezzi; M. R. Antognazza; M. Di Paolo; M. Mete; R. Maccarone et al. : A polymer-based interface restores light sensitivity in blind rats ; Annual Meeting of The Association for Research in Vision and Ophthalmology (ARVO), Orlando, Florida, USA, May 4-8, 2014.
D. Ghezzi : Optical stimulation of neurons and optogenetics ; Invited Talk at OLIMPIA-ITN Summer School, London, UK, January 22, 2014.
D. Ghezzi : NeuroEngineering tools for the investigation and restoration of the visual sense ; Invited Talk at Neuroservice, Aix-en-Provence, France, June 6, 2014.
D. Ghezzi : NeuroEngineering approaches applied to the investigation of photoreceptor degeneration and to the restoration sight ; Invited Talk at École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, June 26, 2014.
D. Ghezzi : NeuroEngineering approaches applied to the restoration of sight ; Invited seminar at Neuroservice, Aix-en-Provence, France, August 20, 2014.
D. Ghezzi : A polymer-based interface restores light sensitivity in blind rats ; Invited Talk at Neuro-Electronics Research Flanders, Leuven, Belgium, September 11, 2014.
D. Ghezzi : Optogenetic strategies for vision restoration ; Invited Talk at OLIMPIA-ITN Summer School, Sestri Levante, Italy, September 23, 2014.
D. Ghezzi; M. R. Antognazza; M. Mete; G. Pertile; G. Lanzani et al. : A polymer-based interface restores light sensitivity in blind rats ; MERIDIAN 30M Workshop, Brixen, Italy, September 25, 2014.
D. Ghezzi : A polymer-based interface restores light sensitivity in blind rats ; Invited Talk at Institute for Bioengineering of Catalonia, Barcelona, Spain, October 1, 2014.
G. Lanzani; D. Ghezzi; M. R. Antognazza; F. Benfenati : The organic approach toward an artificial retina ; 12th European Conference on Molecular Electronics (ECME2013), London, UK, September 3-7, 2013.
D. Ghezzi : Organic artificial photoreceptors to restore sight in blindness ; Invited Talk at Institute of Neuroscience, CNR, Milano, Italy, May 24, 2013.
J. Szczurkowska; M. Dal Maschio; A. W. Cwetsch; D. Ghezzi; G. Bony et al. : Increased performance in genetic manipulation by modeling the dielectric properties of the rodent brain ; 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Osaka, 3-7 July 2013.
L. Cancedda; M. Dal Maschio; D. Ghezzi; G. Bony; A. Alabastri et al. : High-Performance And Site-Directed In Utero Electroporation By A Triple-Electrode Probe ; 8th Forum of European NeuroScience (FENS), Barcelona, Spain, July 14-18, 2012.
F. Benfenati; D. Ghezzi; M. R. Antognazza; M. Dal Maschio; E. Lanzarini et al. : A Hybrid Bio-Organic Interface For Neuronal Photo-Activation ; 8th Forum of European NeuroScience (FENS), Barcelona, Spain, July 14-18, 2012.
D. Ghezzi; E. Lanzarini; N. Martino; R. Maccarone; M. R. Antognazza et al. : Organic electronics allows the photo-electric excitation and inhibition of neuronal activity in primary neuronal cultures and acute retinal explants ; 6th Annual Meeting of Young Researchers in Physiology (YRP), Sestri Levante, Italy, May 30 - June 1, 2012.
G. Lanzani; M. R. Antognazza; E. Lanzarini; N. Martino; D. Ghezzi et al. : Opto-neuronal Interfaces and the Perspective Toward Artificial Retina ; 2012 International Conference on Fiber Optics and Photonics (PHOTONICS), Chennai, India, December 9-12, 2012.
D. Ghezzi; A. Pedrocchi; A. Menegon; S. Mantero; F. Valtorta et al. : A new optical tool to combine optical and electrical analysis in neuronal drug screening ; 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST), Shanghai, China, May 28 - June 5, 2007.
D. Ghezzi; A. Pedrocchi; A. Menegon; S. Mantero; F. Valtorta et al. : PhotoMEA: a new optical biosensor for the study of the functional properties of neuronal networks ; 3rd International Congress of Nanotechnology (ICNT), San Francisco, California, USA, October 30 - November 2, 2006.
D. Ghezzi; A. Menegon; A. Pedrocchi; S. Mantero; F. Valtorta et al. : PhotoMEA: development of optical tools for the study of the functional properties of neuronal networks ; Neuroscience 2006 (SFN), Atlanta, Georgia, USA, October 14-18, 2006.
Ce cours vise à introduire aux étudiants la science des matériaux en mettant l¿accent sur ses applications biologiques.
Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Within a visual angle of 46.3 degrees, POLYRETINA embeds more than 6000 stimulating pixels, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated aging shows a lifetime of at least 2 years. POLYRETINA represents a significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.
In the last decade, research on vision prosthetics has been focused primarily on retinal prostheses. However, optic nerve represents the preferred point of implantation in order to treat patients not eligible for retinal prostheses (e.g. optic nerve diseases). In our laboratory, we are developing a novel intraneural electrode array (named OpticSELINE) that is effective in inducing the activation of the visual cortex upon electrical stimulation of the optic nerve. The OpticSELINE induces selective cortical activation patterns depending on the stimulating electrode, thus suggesting that it possesses spatial selectivity in fiber stimulation.

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