Source: http://www.asmscience.org/content/book/10.1128/9781555815561.ch14
Timestamp: 2019-04-24 06:28:40+00:00

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Transcription and replication products of rhabdoviruses. The full-length triphosphate genome and antigenome RNAs are present exclusively in an NC RNP. The genome NC is the template for production of a short triphosphate leader RNA and sequential transcription of five monocistronic capped and polyadenylated mRNAs. Since the polymerase complex P/L eventually dissociates from the template, a transcription gradient is generated. Replicative synthesis of full-length antigenomes involves concurrent packaging by N/P complexes into an NC.
IFN antagonists of RV and VSV. Rhabdovirus triphosphate RNAs are recognized by RIG-I, resulting in association of the CARD domains of RIG-I and IPS-1 and recruitment of a complex in which IRF3 is phosphorylated by TBK1. Phosphorylation results in dimerization of IRF3, import into the nucleus, and transcriptional activation of the IFN-β gene. In the presence of RV P, IRF3 phosphorylation is prevented. RV P binds also to phosphorylated Stat1 and Stat2, preventing expression of ISGs after IFN stimulation of the IFN receptor (IFNAR). VSV M causes a shutdown of Pol II transcription, thereby preventing transcription of both IFN genes and ISGs. In addition, VSV M interferes with the nuclear export of mRNAs by blocking Nup98 (see text for details).
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