Source: http://biomedpharmajournal.org/vol11no4/the-indifference-of-daily-wearing-of-corrective-linen-in-relation-to-platelet-activity-in-women-of-second-adulthood-with-first-degree-hypoid-obesity/
Timestamp: 2019-04-20 04:58:16+00:00

Document:
Bikbulatova A. A, Medvedev I. N. The Indifference of Daily Wearing of Corrective Linen in Relation to Platelet Activity in Women of Second Adulthood With First Degree Hypoid Obesity. Biomed Pharmacol J 2018;11(4).
Bikbulatova A. A and Medvedev I. N.
Russian State Social University, Moscow, Russia.
Despite the long and systematic efforts of modern medicine, obesity in women in developed countries is still a fairly common condition. Particular attention to this problem is caused by an increase in recent years in the number of cases of this pathology among women of working age who do not have the opportunity to regularly visit fitness halls and comply with various dietary restrictions. In this connection, the problem arises of cosmetic correction of their figures with minimal costs and efforts on the part of women. An exit from the given situation can be wearing corrective clothes, capable to lower volumetric sizes of a body by mechanical influence on it in problem sites. In the work, an evaluation was made of the safety of prolonged wearing of the author's version of the trousers, taking into account hematological and haemostasiological indices. It was found that in women with obesity of grade 2, who received this correction, there was a persistent retention of the measured values ​​within the limits of the norm. The use of the author's version of corrective clothing in women with obesity was accompanied by a visual decrease in the size of their body at the place of wearing the used product. At the same time they had a stably normal level of platelet aggregation, corresponding to the values ​​of control. The obtained results allow to consider the author's corrective clothing as a full and safe component of visual correction of obesity manifestations in women.
Earlier, in clinical trials10,11 and in experiments12,13,14 it was shown that many non-drug effects on the body affect its blood, including the aggregation of its cells.15 In previous studies, it was also found that the use of non-pharmacological agents can reduce the level of platelet activity to a greater or lesser extent.16 Considering that for the bulk of working women with obesity, a low commitment to regular exercise is characteristic.17 In this connection, different versions of corrective clothing may be very promising for them.18 The most important requirement to it should be the preservation of health in women who carry it,19 including the preservation of a stable normal and very significant level of platelet aggregation for microcirculation. In this connection, the goal is to assess the dynamics of platelet aggregation activity important for microcirculation in women of the second adulthood with first degree obesity and obesity, daily wearing the author’s version of corrective clothing for 6 months.
The work was performed on people living in Central Russia (Moscow and Moscow region). In the study, 33 clinically healthy women of the second adulthood (mean age 42.1±2.2 years). They formed a control group. Also, 45 clinically healthy women of the same age (mean age 43.2±1.8 years) with obesity of 1 degree in the gynoid type, who made up the observation group, were taken under observation. The diagnosis of obesity was in all cases set according to generally accepted criteria. The accompanying chronic diseases (chronic bronchitis, chronic tonsillitis, chronic cholecystitis) in some individuals from the observation group were in a state of prolonged persistent remission. The main criterion for selection in the observation group was the desire for women to look more slim without diet and exercise. In the control group, clinically healthy women were selected without any chronic diseases. This research is approved by the local Ethics Committee of the Russian State Social University on May, 14th, 2015 (Record №5). All the examined persons gave written informed consent on participation in conducted research.
The concentration of P-selectin and РЕСАМ-1 molecules (Bender MedSystems GmbH, Austria) was determined by plasma enzyme immunoassay.
Women of the observation group were examined and examined at the end and after 3 and 6 months of daily wearing corrective clothing. Women control is inspected and examined once.
Received in our research results were processes by Student’s (t)criterion.
During the entire period of wearing corrective clothing, in no case have complaints of discomfort or worsening of the initial well-being. In all cases, women were satisfied with the achievement of a more slender figure in the initially problematic areas (hips).
Daily wearing of corrective clothing was accompanied by the retention of observed low-level lipid peroxidation in observed women with obesity. So, in 3 months the amount of AGP and thiobarbituric acid in the plasma remained unchanged at 1.72±0.046 D233/1 ml and 3.25±0.040 μmol/l (in the control 1.74±0.032 D233/1ml and 3.22±0.037 μmol/l, respectively). By 6 months wearing corrective clothing, the content of AHP in the plasma of the observed women was 1.76±0.041 D233/1ml with the level of thiobarbituric acid-active compounds 3.21±0.038 μmol/l in the background against the stability of the antioxidant activity of the plasma (32.0±0.44% in the end and 32.4±0.40% at the end of the observation). As a result of wearing the author’s version of the corrective clothing, the concentration of normal concentrations in the plasma of adhesion molecules taken into account was noted in women (Table 1). For half a year of observation in obese women, the levels of P-selectin and RESAM-1 remained at the same level, significantly not differing from the level of control.
As a result, 3 months. Daily wear of corrective clothing in membranes of platelets of obese women noted the preservation at the control level of CS0.81±0.008 μmol/109 platelets and CPL0.73±0.007 μmol/109 platelets (at the end of 0.80±0.010 μmol/109 platelets and 0.74±0.006 μmol/109 platelets, respectively). Continuation of the use of corrective clothing did not affect the state of lipid composition of platelets (CS0.81±0.007 μmol/109 platelets, CPL0.73±0.009 μmol/ 109 platelets), retaining its values ​​at the control level (CS0.81±0.012 μmol/109 platelets and CPL0.74±0.007 μmol/109 platelets).
Initially had low activity platelets observed obese women, LPO remained at a level close to the end of 3 months daily wearing corrective clothing. After 6 months. The continuous use of LPO products in platelets of women in the study was also preserved without dynamics (AHP 3.05±0.013 D233/109 platelets and MDA 1.36±0.012 nmol/109 platelets, respectively) and corresponding to the control level (AHP 3.12 ±0.014 D233/109 platelets, MDA 1.35±0.008 nmol/109 platelets, respectively).
Daily use of corrective clothing in women was not accompanied by significant dynamics of platelet hemostasis activity. The number of platelets in their blood is still at the normal level. At the same time, initially normal platelet aggregation in women with obesity as a result of wearing the author’s version of corrective clothing remained within the norm. As a result of the daily wearing of corrective clothing, the stability of the AT in response to all tested inductors at a level close to the control was recorded in the observed women. In this case, the most active response of platelets in them was identified for collagen, ADP and ristomycin. Less active was the AP with H2O2 and thrombin. The maximum duration of development of AP was observed in women with obesity, wearing the author’s version of corrective clothing, in response to adrenaline – 94.8±0.28 s (Table 1).
Table 1: The dynamics of hematological indicators in obese women, who daily carried the author’s version of corrective clothing.
It is known that in society there are some unsubstantiated fears about the possibility of negative influence of corrective clothing on microcirculatory processes in tissues. To completely eliminate all doubts in this regard, the present study was conducted.
The found preservation of the AP time in the observed women, who daily carried corrective author’s clothes, can be regarded as a consequence of the maintenance of the invariability of LPO intensity in plasma and platelets and the optimum state of thrombocyte membranes.33,34 This ensures stability of normal functioning of receptor and postreceptor mechanisms in platelets.35 A sufficiently long time of development of AP under the influence of ristomycin in obese women in the presence of corrective clothing should be attributed to the invariably low level of von Willebrand factor in their blood.36 The relatively high resistance of their platelets to hydrogen peroxide was indicated by the preservation of the optimal duration of AP with H2O2. This indicated a constant high activity of the antioxidation system in platelets. The found stability of the time of AP against the background of the daily wearing of corrective clothing is obviously associated in women with obesity, not only with a low activity of LPO in the platelet membranes, but also with the basal activity of the enzymes of their thromboxane formation. This was indicated by the preservation of a high duration of AP with weak inducers, which is realized through the mechanism of thromboxane formation.
It becomes clear that for 6 months of applying corrective clothing in obese women, low activity of LPO processes in plasma and platelets is preserved, ensuring the stability of their normal aggregation and its compliance with the level of control.37,38,39 This indicates the complete safety of the tested version of corrective clothing in terms of platelet aggregation rates,40,41 which largely determine the rheological properties of blood in the capillaries.42,43 In this regard, we can assume that wearing an author’s version of corrective clothing is indifferent to significant platelet activity for microcirculation and can be worn by women for a long time.
In recent years, among working women with signs of obesity, the popularity of wearing corrective clothing is growing. Its use is an affordable alternative to dietary restrictions and regular very active physical activity in order to achieve a more slender figure. Given that the use of this clothing should occur daily, the issue of its safety in relation to the very significant platelet aggregation for microcirculatory processes is very topical. It was found that a 6-month daily wearing of corrective clothing keeps well-being in obese women and does not cause discomfort. Its use does not affect lipid peroxidation in plasma and platelets. In addition, daily for six months wearing women with obesity corrective clothing is accompanied by the preservation of normal aggregation activity of platelets. The obtained results make it possible to consider the use of the author’s version of corrective clothing for full-fledged and safe variants of correction of a female figure for obesity that does not disrupt microcirculation in tissues during prolonged use.
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