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Table II.11. Examples of targeted natural genetic engineering.
Strong preference for insertion upstream of RNA polymerase III initiation sites (protein-protein interaction of integrase with RNA polymerase III factors TFIIIB and TFIIIC).
Preference for insertion upstream of RNA polymerase II initiation sites rather than exons.
Strong preference for insertion in transcriptionally silenced regions of the yeast genome (protein-protein interaction of integrase targeting domain (TD) with Sir4 silencing protein). Regulated in response to stress by modulation of integrase TD protein phosphorylation.
Insertion almost exclusively in intergenic regions (>98% for Tf1); biased towards PolII promoter-proximal sites, 100 – 400 bp upstream of the translation start by protein-protein interaction with transcription activators; prefers chromosome 3.
Insertion after intrinsic transcriptional terminators.
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