Source: http://www.univ-angers.fr/fr/acces-directs/annuaire-2/f/e/uduser-marc-ferre-fr.html
Timestamp: 2019-04-22 04:07:10+00:00

Document:
Research activity of Dr Ferré has been conducted in the field of mitochondrial diseases.
He began is career by studying in silico the human mitochondrial proteome and developing a bioinformatics research strategy to identify new mitochondrial proteins on the basis of their prokaryotic origin. In parallel to this overall strategy of screening, he focused on the study of the Opa1 protein, one of the proteins associated with autosomal dominant optic atrophy, which is involved in mitochondrial fusion. Opa1, a dynamin GTPase, is involved in the remodeling of the mitochondrial inner membrane, apoptosis, maintenance of mitochondrial DNA, and energy metabolism. He finally developed an international database listing the variations of Opa1 so as to characterize its mutational spectrum. This tool was used as a complement to a multicentric clinical study involving nearly a thousand patients with optic neuropathy. His work has led to the development of novel bioinformatics tools that should contribute to a better understanding of mitochondrial pathophysiology.
He is currently focused on three areas: 1) obtaining mitochondrial genetic information by developing the 3rd generation Nanopore sequencing, an innovative technique for sequencing mitochondrial DNA in which double-stranded DNA is read directly without DNA amplification or incorporation of nucleotides; 2) the establishment of biomedical databases, as a member of the Human Variome Project Gene Disease Specific Database Advisory Council since 2012; 3) Big data, an area of research which follows the need to analyze large amounts of data generated by the previous two axes and open data policy.
Marc Ferré graduated in 2002 from a French Grande Ecole of Engineering (ESEO) and in December 2009 a PhD in Bioinformatics. Until August 2014, he was employed by the University Hospital of Angers (France) as bioinformatician through the formation of a national network coordinated by the French Department of Health and Social Affairs (genetic study of neuromuscular and sensory pathologies and mental retardation).
He is currently Associate Professor in Molecular Biology and Bioinformatics at the Angers Medical School.
He is also a staff-member to the research team Mitolab (mitolab.eu) of the UMR CNRS 6214/INSERM 1083 — CNRS, The Centre National de la Recherche Scientifique (National Center for Scientific Research), is a government-funded research organization, under the administrative authority of France's Ministry of Research; INSERM, the Institut national de la santé et de la recherche médicale (French National Institute of Health and Medical Research), is a public scientific and technological institute which operates under the joint authority of the French Ministry of Health and French Ministry of Research.
Mitochondrial diseases preferentially involve proteins with prokaryote homologues.Y. Tourmen, M. Ferre, Y. Malthiery, P. Dessen and P. Reynier. C R Biol, 2004.
Sporadic optic atrophy due to synonymous codon change altering mRNA splicing of OPA1.P. Amati-Bonneau, L. Pasquier, E. Lainey, M. Ferre, S. Odent, Y. Malthiery, D. Bonneau and P. Reynier. Clin Genet, 2005.
eOPA1: an online database for OPA1 mutations.M. Ferre, P. Amati-Bonneau, Y. Tourmen, Y. Malthiery and P. Reynier. Hum Mutat, 2005.
Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease.D. Loiseau, A. Chevrollier, C. Verny, V. Guillet, N. Gueguen, M. A. Pou de Crescenzo, M. Ferre, M. C. Malinge, A. Guichet, G. Nicolas, P. Amati-Bonneau, Y. Malthiery, D. Bonneau and P. Reynier. Ann Neurol, 2007.
Genotype-phenotype correlation in mitochondrial optic neuropathies.C. Verny, P. Amati-Bonneau, M. Ferre, M. Barth, V. Guillet, A. Chevrollier, Y. Malthierry, F. Dubas, D. Bonneau and P. Reynier. Neurology, 2007.
Carotid artery dissection in an adult with the Simpson-Golabi-Behmel syndrome.I. Penisson-Besnier, T. Lebouvier, M. P. Moizard, M. Ferre, M. Barth, G. Marc, M. Raynaud and D. Bonneau. Am J Med Genet A, 2008.
Hereditary optic neuropathies share a common mitochondrial coupling defect.A. Chevrollier, V. Guillet, D. Loiseau, N. Gueguen, M. A. de Crescenzo, C. Verny, M. Ferre, H. Dollfus, S. Odent, D. Milea, C. Goizet, P. Amati-Bonneau, V. Procaccio, D. Bonneau and P. Reynier. Ann Neurol, 2008.
Reversible optic neuropathy with OPA1 exon 5b mutation.K. Cornille, D. Milea, P. Amati-Bonneau, V. Procaccio, L. Zazoun, V. Guillet, G. El Achouri, C. Delettre, N. Gueguen, D. Loiseau, A. Muller, M. Ferre, A. Chevrollier, D. C. Wallace, D. Bonneau, C. Hamel, P. Reynier and G. Lenaers. Ann Neurol, 2008.
Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K).J. Cassereau, A. Chevrollier, N. Gueguen, M. C. Malinge, F. Letournel, G. Nicolas, L. Richard, M. Ferre, C. Verny, F. Dubas, V. Procaccio, P. Amati-Bonneau, D. Bonneau and P. Reynier. Neurogenetics, 2009.
Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations.M. Ferre, D. Bonneau, D. Milea, A. Chevrollier, C. Verny, H. Dollfus, C. Ayuso, S. Defoort, C. Vignal, X. Zanlonghi, J. F. Charlin, J. Kaplan, S. Odent, C. P. Hamel, V. Procaccio, P. Reynier and P. Amati-Bonneau. Hum Mutat, 2009.
OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background.D. Pierron, M. Ferre, C. Rocher, A. Chevrollier, P. Murail, D. Thoraval, P. Amati-Bonneau, P. Reynier and T. Letellier. BMC Med Genet, 2009.
Hereditary Optic Neuropathies Share a Common Mitochondrial Coupling Defect.C. Verny, P. Amati-Bonneau, A. Chevrollier, V. Guillet, D. Loiseau, N. Gueguen, M. P. de Crescenzo, M. Ferre, H. Dollfus, S. Odent, D. Milea, C. Goizet, V. Procaccio, F. Dubas, P. Reynier and D. Bonneau. Neurology, 2009.
A Novel Dominant C240Y Mutation in GDAP1 Associated with a Mitochondrial Complex I Deficiency and Mitochondrial Structural Modifications.J. Cassereau, C. Verny, A. Chevrollier, N. Gueguen, M. Ferre, M. C. Malinge, P. Amati-Bonneau, V. Procaccio, P. Reynier, F. Dubas and D. Bonneau. Neurology, 2009.
Acute and late-onset optic atrophy due to a novel OPA1 mutation leading to a mitochondrial coupling defect.Y. Nochez, S. Arsene, N. Gueguen, A. Chevrollier, M. Ferre, V. Guillet, V. Desquiret, A. Toutain, D. Bonneau, V. Procaccio, P. Amati-Bonneau, P. J. Pisella and P. Reynier. Molecular Vision, 2009.
OPA1-associated disorders: phenotypes and pathophysiology.P. Amati-Bonneau, D. Milea, D. Bonneau, A. Chevrollier, M. Ferre, V. Guillet, N. Gueguen, D. Loiseau, M. A. de Crescenzo, C. Verny, V. Procaccio, G. Lenaers and P. Reynier. Int J Biochem Cell Biol, 2009.
[Hereditary optic atrophies].C. Scherer, V. Procaccio, M. Ferre, V. Guillet, P. Reynier, P. Amati-Bonneau, F. Dubas, D. Bonneau and C. Verny. Rev Neurol (Paris), 2010.
Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease.V. Guillet, N. Gueguen, C. Verny, M. Ferre, C. Homedan, D. Loiseau, V. Procaccio, P. Amati-Bonneau, D. Bonneau, P. Reynier and A. Chevrollier. Neurogenetics, 2010.
Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration.C. Angebault, N. Gueguen, V. Desquiret-Dumas, A. Chevrollier, V. Guillet, C. Verny, J. Cassereau, M. Ferre, D. Milea, P. Amati-Bonneau, D. Bonneau, V. Procaccio, P. Reynier and D. Loiseau. BMC Res Notes, 2011.
A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K.J. Cassereau, A. Chevrollier, D. Bonneau, C. Verny, V. Procaccio, P. Reynier and M. Ferre. Orphanet J Rare Dis, 2011.
Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation.C. Verny, N. Guegen, V. Desquiret, A. Chevrollier, A. Prundean, F. Dubas, J. Cassereau, M. Ferre, P. Amati-Bonneau, D. Bonneau, P. Reynier and V. Procaccio. Mitochondrion, 2011.
Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function.A. Chevrollier, J. Cassereau, M. Ferre, J. Alban, V. Desquiret-Dumas, N. Gueguen, P. Amati-Bonneau, V. Procaccio, D. Bonneau and P. Reynier. Int J Biochem Cell Biol, 2012.
Sensorineural hearing loss in OPA1-linked disorders.S. Leruez, D. Milea, S. Defoort-Dhellemmes, E. Colin, M. Crochet, V. Procaccio, M. Ferre, J. Lamblin, V. Drouin, C. Vincent-Delorme, G. Lenaers, C. Hamel, C. Blanchet, G. Juul, M. Larsen, C. Verny, P. Reynier, P. Amati-Bonneau and D. Bonneau. Brain, 2013.
Prevalence of rare mitochondrial DNA mutations in mitochondrial disorders.S. Bannwarth, V. Procaccio, A. S. Lebre, C. Jardel, A. Chaussenot, C. Hoarau, H. Maoulida, N. Charrier, X. Gai, H. M. Xie, M. Ferre, K. Fragaki, G. Hardy, B. Mousson de Camaret, S. Marlin, C. M. Dhaenens, A. Slama, C. Rocher, J. Paul Bonnefont, A. Rotig, N. Aoutil, M. Gilleron, V. Desquiret-Dumas, P. Reynier, J. Ceresuela, L. Jonard, A. Devos, C. Espil-Taris, D. Martinez, P. Gaignard, K. H. Le Quan Sang, P. Amati-Bonneau, M. J. Falk, C. Florentz, B. Chabrol, I. Durand-Zaleski and V. Paquis-Flucklinger. J Med Genet, 2013.
Is ABCC6 a genuine mitochondrial protein?M. Ferre, P. Reynier, A. Chevrollier, D. Prunier-Mirebeau, G. Leftheriotis, D. Henrion, D. Bonneau, V. Procaccio and L. Martin. BMC Res Notes, 2013.
Resveratrol Induces a Mitochondrial Complex I Dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells.V. Desquiret-Dumas, N. Gueguen, G. Leman, S. Baron, V. Nivet-Antoine, S. Chupin, A. Chevrollier, E. Vessieres, A. Ayer, M. Ferre, D. Bonneau, D. Henrion, P. Reynier and V. Procaccio. J Biol Chem, 2013.
Are zona pellucida genes involved in recurrent oocyte lysis observed during in vitro fertilization?M. Ferre, P. Amati-Bonneau, C. Moriniere, V. Ferre-L'hotellier, S. Lemerle, D. Przyrowski, V. Procaccio, P. Descamps, P. Reynier and P. May-Panloup. J Assist Reprod Genet, 2014.
Early-onset Behr syndrome due to compound heterozygous mutations in OPA1. D. Bonneau, E. Colin, F. Oca, M. Ferre, A. Chevrollier, N. Gueguen, V. Desquiret-Dumas, S. N'Guyen, M. Barth, X. Zanlonghi, M. Rio, I. Desguerre, C. Barnerias, M. Momtchilova, D. Rodriguez, A. Slama, G. Lenaers, V. Procaccio, P. Amati-Bonneau and P. Reynier. Brain, 2014.
Are zona pellucida genes involved in recurrent oocyte lysis observed during in vitro fertilization? M. Ferre, P. Amati-Bonneau, C. Moriniere, V. Ferre-L'Hotellier, S. Lemerle, D. Przyrowski, V. Procaccio, P. Descamps, P. Reynier and P. May-Panloup. J Assist Reprod Genet, 2014.
Improved Locus-Specific Database for OPA1 Mutations Allows Inclusion of Advanced Clinical Data. M. Ferre, A. Caignard, D. Milea, S. Leruez, J. Cassereau, A. Chevrollier, P. Amati-Bonneau, C. Verny, D. Bonneau, V. Procaccio and P. Reynier. Hum Mutat, 2015.

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