Source: http://www.asmscience.org/content/book/10.1128/9781555815851.ch06
Timestamp: 2019-04-23 02:13:13+00:00

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Signaling complexity is related to genome size. Shown are the numbers of signaling systems (one- and two-component systems) corresponding to 150 sequenced genomes as a function of genome size (raw data were taken from reference 75 ). Black diamonds, pathogenic bacteria emphasized in the text.
Quorum-sensing circuitry. The schematic emphasizes the acyl-HSL signals, genes, and corresponding protein components of each quorum-sensing system. Circles denote acyl-HSL signals. Boxes upstream of target genes indicate conserved regulatory elements to which LasR, RhlR, or QscR bind. Some target (tgt) genes within the quorum-sensing regulon are activated by both LasR and RhlR.
Interconnection of quorum sensing with other regulatory networks. See the text for a detailed explanation. For enhanced clarity, effects on signal synthase and receptor expression have not been detailed separately. PA1760 is one of several predicted transcriptional regulators that is activated by las quorum sensing and appears to mediate quorum-sensing gene expression indirectly. The quorum-sensing regulon is defined as the collection of genes that is activated by LasR–3OC12-HSL or RhlR–C4-HSL, directly or indirectly. The different regulators shown affect the expression of overlapping subsets within the quorum-sensing (QS) regulon. ppGpp, guanosine tetraphosphate.
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