Source: http://niikelsoramn.ru/institut/podrazdelenija/lab-klinicheskoi-immunogenetiki/clinical-immunogenetics/
Timestamp: 2019-04-18 20:41:01+00:00

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The laboratory has arsenal of unique laboratory equipment that enables high-precision testing of biological active molecules at minimum time. Applied molecular biology techniques: genotyping, PCR-diagnostics, flow cytometry, Elisa etc. These methods can be used, and for scientific purposes, and in medical practice.
Laboratory is managed by the member of Russian Academy of Science, Professor Vladimir I. Konenkov. He is a prominent leader in the field of immunogenetic bases of human pathology.
- cellular and molecular-genetic mechanisms of development of immune-mediated human diseases.
One of the first in Russia Professor V. Konenkov described the phenomenon of cytokine activation associated with entering into circulation and its essential role in human autoimmune processes.
These data had been given further support to notion of the key role of histocompatibility molecules biogenesis in the processes of realization of functions of the immune system. For the first time it has been proven that the chance of developing encephalitis after the bite of an infected tick is associated with the allelic variants of HLA genes.
Some allelic variants of the genes of cytokines associated with susceptibility and resistance to the development of AIDS and hepatitis C were identified and ability to predict fast and slow development of AIDS in HIV-infected patients was proven.
Professor V. Konenkov oversaw the development and implementation of automated expert estimations of human immune system states and establishment of immunogenetic ensure the transplantation of organs and tissues in the Siberian region.
His current research interests are related to immunogenetics features of development of multifactorial diseases.
She is an author of 135 articles in peer-reviewed journals.
Dr. V. Prokof’iev graduated from the Medical Faculty of the Novosibirsk State Medical Institute in 1972. Since 1975, after finishing graduate school, he worked as an assistant of the Department of normal anatomy of the Novosibirsk Medical Institute. Since 1981, he works as a leading researcher in the Laboratory of Clinical Immunogenetics at first in the Institute of Fundamental and Clinical Immunology, and since 2005 - in the Institute of Clinical and Experimental lymphology.
His current research interests include the Population and Clinical Immunogenetics human, gene networks and modeling of stochastic processes. He is a Specialist in the development of automated systems and methods for early diagnosis and prognosis of human multifactorial diseases based on bioinformatics analysis of the genome of the cytokine.
He is an author of 118 articles in peer-reviewed journals.
Dr. N. Svechnikova graduated from the Pediatric Faculty of the Novosibirsk State Medical Institute in 1976, completed training in clinical residency. She defended candidate and doctoral dissertations in specialty "skin and venereal disease".
Her scientific interests are connected with manifestations of skin diseases in diseases of the digestive system and endocrine system, histological changes of the skin and the lymphatic system in dermatoses.
Provides advice of the doctor-dermatovenerologist. In practical medical activity uses the methods of endoecological rehabilitation.
She is an author of 134 articles in peer-reviewed journals.
Dr. N. Orlov graduated from the Medical Faculty of the Novosibirsk State Medical Institute in 1980. Since 1981, after graduating from clinical residency, he works first as a junior and later as a senior researcher at the Scientific Research Institute for Fundamental and Clinical Immunology. Since 2005 he works at the Research Institute of Clinical and Experimental Lymphology.
His current research interests include the X map technology, flow fluorometry. He is a Specialist in the Production of cytokines and chemokines for various diseases and pathological conditions, Methods of infection diagnosis, the role of infections in the pathogenesis of autoimmune diseases.
He is an author of 34 articles in peer-reviewed journals.
Fazullina ON, Klimontov VV, Konenkov VI, Shevchenko AV, Prokofiev VF, Tsepilov YA. Associations of polymorphisms in the gene promoters of cytokines and matrix metalloproteinases with bone mineral density in postmenopausal type 2 diabetic women. Diabetes Mellitus. 2018;21(1):26-33. doi: 10.14341/DM8825.
1. Shevchenko A.V., Prokofyev V.F., Korolev M.A., Banshchikova N.E., Konenkov V.I. Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis // Terapevticheskiy arkhiv. - 2017.-Vol.89.- N.5. - P.60-64.
2. Klimontov V.V., Tyan N.V., Orlov N.B., Shevchenko A.V., Prokofiev V.F., Myakina N.E., Bulumbaeva D.M., Konenkov V.I. Association of Serum Levels and Gene Polymorphism of Vascular Endothelium Growth Factor With Ischemic Heart Disease in Type 2 Diabetic Patients // Kardiologiya. - 2017.- Vol.57.- N.5.- P. 17-22.
3. Chernykh V., Trunov A., Shevchenko A., Prokofiev V. Vascular Endothelial Growth Factor, Matrix Metalloproteinases and Tumor Necrosis Factor-α Complex Genetic Polymorphisms in Age-Related Macular Degeneration // Ophthalmic Res 2017;58(suppl 1):1–2.
4. Konenkov V.I., Shevchenko A.V., Prokof`ev V.F., Klimontov V.V., Tyan N.V., Chernykh V.V., Chernykh D.V., Eremina A.V., Trunov A.N. Combinations of polymorphisms in the regulatory regions of cytokine genes are associated with diabetic retinopathy in type 2 diabetic patients. Bulletin of Siberian Medicine. 2017; 16(4): 173-183. doi: 10.20538/1682-0363-2017-4-173-183.
6. Bulumbaeva DM, Klimontov VV, Tyan NV, Orlov NB, Konenkov VI. Serum levels of angiogenic growth factors in subjects with type 2 diabetes with and without peripheral artery disease. Diabetologia. 2017; 60 (Suppl. 1): S526. doi: 10.1007/s00125-017-4350-z.
7. Korbut AI, Klimontov VV, Bgatova NP, Gavrilova YS, Ischenko IY, Orlov NB, Dozenko AS, Zavjalov EI. Linagliptin alleviates podocyte injury and enhances glomerular nephrin expression in a model of type 2 diabetes. Diabetologia. 2017; 60 (Suppl. 1): S550. doi: 10.1007/s00125-017-4350-z.
8. Fazullina ON, Klimontov VV, Konenkov VI, Shevchenko AV, Prokofiev VF, Tsepilov YA. Modeling the risk of osteopenia and osteoporosis in postmenopausal women with type 2 diabetes on the sets of clinical and immunogenetic parameters. 2017 International MultiConference on Engineering, Computer and Information Sciences (SIBIRCON). Novosibirsk, Russia, 18-24 September 2017.
1. Shevchenko A.V. , Konenkov V.I., Prokof'ev V.F., Poveshchenko O.V., Lykov A.P., Bondarenko N.A., Kim I.I. Constitutional basis of the levels of spontaneous and induced production of cytokines TNA-a, IL-1β, IL-4, IL-6 and IL-10 in healthy individuals of the european population of Russia // Immunology. – 2016. - Vol. 37, No. 5. - P. 232-238. Russian.
2. Shevchenko A. V., Prokof’ev V. F., Konenkov V. I., Chernykh V. V., Eremina A. V., Dudnikova L. V., Kashkin, N. Yu., Trunov A. N. Cytokine gene polymorphisms in patients with age-related macular degeneration // Vestnik of ophthalmology. - 2016. - Vol. 132, No. 2. - P. 8-13. Russian.
3. Shevchenko A.V., Konenkov V. I., Prokof’ev V. F., Ragino Y. I., Cherniavsky A. M., Voevoda M. I.
The associating of the number of homozygous genotypes gene regulation of inflammation, destruction and angiogenesis laboratory markers of atherosclerosis in men with stable angina // Cardiology. - 2016. - Vol. 56, No. 3. -P. 5-11. Russian.
4.Prokof’ev V. F., Shevchenko A. V., Konenkov V. I. Analysis of cytokine genome for female infertility // In the book: “Lymphology: from fundamental research to medical technology.” Materials of XII international conference, dedicated to the 25th anniversary of the research Institute of clinical and experimental lymphology. - Novosibirsk, 2016. - P. 212-215. Russian.
1: Shevchenko AV, Konenkov VI, Korolev MA, Ubshaeva YB, Prokofiev VF. [Matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis]. Ter Arkh. 2015;87(12):36-40. Russian.
4: Shevchenko AV, Konenkov VI, Garbukov EIu, Stakheeva MN. [Associating of polymorphism in the promoter regions of genes of metalloproteinase (MMP2, MMP3, MMP9) with options of the clinical course of breast cancer in Russian women]. Vopr Onkol. 2014;60(5):630-5. Russian.
7: Konenkov VI, Shevchenko AV, Prokof'ev VF, Maksimov VN. [Complex of genotypes of cytokines as a genetic factor of risk of development of myocardial infarction of in Europien population of Russia men]. Kardiologiia. 2012;52(7):22-9. Russian.
8: Shevchenko AV, Konenkov VI, Garbukov EIu, Stakheeva MN. [Polymorphism of regulatory regions of growth factor gene of vascular endothelium VEGFA in breast cancer patients with family history]. Vopr Onkol. 2012;58(6):773-6. Russian.
1. Bulumbaeva DM, Klimontov VV, Tyan NV, Orlov NB, Konenkov VI. Serum levels of angiogenic growth factors in subjects with type 2 diabetes with and without peripheral artery disease. 53th Annual Meeting of the European Association for the Study of Diabetes. Lisbon, Portugal, 11-15 September 2017: PP 1142.
1. Prokof'ev V.F., Shevchenko A.V., Korolev M.A., Konenkov V.I. Using the techniques of stochastic modeling and inhomogeneous sequential pattern recognition procedure for the prediction the development of polygenic diseases. // The International Symposium “Systems Biology and Biomedicine (SBioMed-2016)”. Abstract Book. - Novosibirsk, Russia, August 30-31, 2016. – P. 85.
2. Shevchenko A.V., Prokof`ev V.F., Konenkov V.I. Commonability of the combinations of polymorphic regulatory sites in the cytokine genes in pathogenetically diverse diseases in women. // The International Symposium “Systems Biology and Biomedicine (SBioMed-2016)”. Abstract Book. - Novosibirsk, Russia, August 30-31, 2016. – P. 95.
3. Shevchenko A.V., Prokof`ev V.F., Konenkov V.I., Eremina A.V., Chernich V.V. Associativity of some genetic factors with development of AMD. // The All-Russia scientific - practical conference with online-translation «Basic researches in ophthalmology» under the aegis of ophthalmologist association of Russia. Novosibirsk, 3 november 2016.
1. Tyan N. V. Shevchenko A. V., Prokof’ev V. F., Bulumbaeva D. M., Polezhaev Y. V., Klimontov V. V., Konenkov, V. I., Analysis of polymorphism of genes of interleukins, growth factors and matrix metalloproteinases in patients with diabetes mellitus type 2 with ischemic heart disease // Diabetes in the XXI century – the time of unification efforts: the VII Russian diabetes Congress. The book of abstracts. – Moscow, 24-27 February 2015. – M.: up Print, 2015. – P. 47.
2. Fazullina O. N., Klimontov V. V., Shevchenko A. V., Prokof’ev V. F., Konenkov V. I. Combinations of gene variants of cytokines and matrix metalloproteinases associated with a decrease in mineral bone density in women with diabetes type 2 diabetes. // Diabetes in the XXI century – the time of unification efforts: the VII Russian diabetes Congress. The book of abstracts. M., 24-27 Feb 2015. – M.: up Print, 2015. – P. 332.

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