Source: https://uclouvain.be/fr/repertoires/catherine.legrand
Timestamp: 2019-04-20 12:19:35+00:00

Document:
Catherine Legrand obtained a Master Degree in Mathematics from the Université Libre de Bruxelles (ULB) in 1998. Before embracing an academic career, she worked for 7 years at the European Organization for Research and Treatment of Cancer (EORTC, Brussels) as the primary statistician of the EORTC Lung Cancer Group. She was also a member of the Treatment Outcome Research Group, the Elderly Task Force, and coordinator of the EORTC Independent Data Monitoring Committee (IDMC). She was involved in the design, monitoring, and analysis of numerous clinical trials. In parallel, she completed a PhD in 2005 at the Center for Statistics, UHasselt, developing new methods based on the frailty model to investigate heterogeneity in cancer multi-center clinical trials. Early 2006, she started working as biometrician at Merck Sharp & Dohme (MSD, Brussels) where she was involved in the design and analysis of clinical trials in respiratory diseases and HIV. Since September 2007, she is full time Professor at the Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA) of the Université catholique de Louvain (UcL), teaching statistics and biostatistics to bachelor and master students.
Main area of research includes survival data (more particularly frailty models and cure models) and design and analysis of multicenter clinical trials (in particular in oncology and vaccine), with an emphasis on treatment effect heterogeneity and central statistical monitoring.
Callegaro, Andrea ; Ndour, Cheikh ; Aris, Emmanuel ; Legrand, Catherine. A note on tests for relevant differences with extremely large sample sizes. In: Biometrical Journal, Vol. 61, no.1, p. 162-165 (2019). doi:10.1002/bimj.201800195.
Burny, Wivine ; Marchant, Arnaud ; Hervé, Caroline ; Callegaro, Andrea ; Caubet, Magalie ; Fissette, Laurence ; Gheyle, Lien ; Legrand, Catherine ; Ndour, Cheikh ; Tavares Da Silva, Fernanda ; van der Most, Robbert ; Willems, Fabienne ; Didierlaurent, Arnaud M. ; Yarzabal, Juan. Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans. In: Vaccine, Vol. 37, no.14, p. 2004-2015 (2019). doi:10.1016/j.vaccine.2019.02.015.
Nicolaie, Mioara Alina ; Taylor, Jeremy M. G. ; Legrand, Catherine. Vertical modeling: analysis of competing risks data with a cure fraction. In: Lifetime Data Analysis, Vol. 25, no.1, p. 1-25 (2019). doi:10.1007/s10985-018-9417-8.
Bertrand, Aurélie ; Van Keilegom, Ingrid ; Legrand, Catherine. Flexible parametric approach to classical measurement error variance estimation without auxiliary data : Classical Measurement Error Variance Estimation. In: Biometrics, to appearVol. to appear (Accepted author version posted online: 04 August 2018), p. n/a-n/a. doi:10.1111/biom.12960.
Denuit, Michel ; Legrand, Catherine. Risk classification in life and health insurance: extension to continuous covariates. In: European Actuarial Journal, Vol. 8, no.1, p. 245-255 (2018). doi:10.1007/s13385-018-0171-9.
Hammer, Jennifer ; Seront, Emmanuel ; Duez, Steven ; DUPONT, Sophie ; Van Damme, An ; Schmitz, Sandra ; Hoyoux, Claire ; Chopinet, Caroline ; Clapuyt, Philippe ; Hammer, Frank ; Legrand, Catherine ; Vikkula, Miikka ; Boon, Laurence. Sirolimus treatment for extensive slow-flow vascular malformations: a monocentric prospective phase-II study. In: Orphanet journal of Rare Diseases, Vol. 13, no. 191, p. 13 (2018).
Amico, Maïlis ; Van Keilegom, Ingrid ; Legrand, Catherine. The Single-Index/Cox Mixture Cure Model. In: Biometrics, to appearVol. to appear (Accepted author version posted online: 14 November 2018), p. n/a-n/a. doi:10.1111/biom.12999 (Accepté/Sous presse).
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Sacré, Laurine ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Corrigendum to "Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy" [Eur J Cancer 67 (2016) 38-45].. In: European Journal of Cancer, Vol. 82, p. 247 (2017). doi:10.1016/j.ejca.2017.06.001.
Bertrand, Aurélie ; Legrand, Catherine ; Carroll, Raymond J. ; de Meester de Ravenstein, Christophe ; Van Keilegom, Ingrid. Inference in a survival cure model with mismeasured covariates using a simulation-extrapolation approach. In: Biometrika, Vol. 104, no. 1, p. 31-50 (2017). doi:10.1093/biomet/asw054.
Bertrand, Aurélie ; Legrand, Catherine ; Léonard, Daniel ; Van Keilegom, Ingrid. Robustness of estimation methods in a survival cure model with mismeasured covariates. In: Computational Statistics & Data Analysis, Vol. 113, p. 3-18 (2017). doi:10.1016/j.csda.2016.11.013.
Desmet, Lieven ; Venet, David ; Doffagne, Erik ; Timmermans, Catherine ; Legrand, Catherine ; Burzykowski, Tomasz ; Buyse, Marc. Use of the beta-binomial model for central statistical monitoring of multicenter clinical trials. In: Statistics in Biopharmaceutical Research, Vol. 9, no. 1, p. 1-11 (2017). doi:10.1080/19466315.2016.1164751.
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Sacré, Laurine ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy. In: European Journal of Cancer, Vol. 67, p. 38-45 (2016). doi:10.1016/j.ejca.2016.07.020.
Scolas, Sylvie ; Legrand, Catherine ; Oulhaj, Abderrahim ; El Ghouch, Anouar. Diagnostic checks in mixture cure models with interval-censoring. In: Statistical Methods in Medical Research, Vol. 27, no. 7, p. 2114-2131 (2018). doi:10.1177/0962280216676502.
Rotolo, Federico ; Rondeau, Virginie ; Legrand, Catherine. Incorporation of nested frailties into semiparametric multi-state models. In: Statistics in Medicine, Vol. 35, no.4, p. 609-621 (2016). doi:10.1002/sim.6734.
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Francart, Julie ; Calay, Frederic ; Haagsma, Juanita A. ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Melanoma burden by melanoma stage: Assessment through a disease transition model. In: European Journal of Cancer, Vol. 53, p. 33-41 (2016). doi:10.1016/j.ejca.2015.09.016.
Timmermans, Catherine ; Doffagne, Erik ; Venet, David ; Desmet, Lieven ; Legrand, Catherine ; Burzykowski, Tomasz ; Buyse, Marc. Statistical monitoring of data quality and consistency in the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial. In: Gastric Cancer, Vol. 19, no. 1, p. 24-30 (2016). doi:10.1007/s10120-015-0533-9.
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine ; Oulhaj, Abderrahim. Variable selection in a flexible parametric mixture cure model with interval-censored data. In: Statistics in Medicine, Vol. 35, no.7, p. 1210-1225 (2016). doi:10.1002/sim.6767.
Benoit, Anne ; Beran, J. ; Devaster, J.-M. ; Esen, M. ; Launay, O. ; Leroux-Roels, G. ; McElhaney, J. E. ; Oostvogels, L. ; van Essen, G. A. ; Gaglani, M. ; Jackson, L. A. ; Vesikari, T. ; Legrand, Catherine ; Tibaldi, F. ; Innis, B. L. ; Dewe, W.. Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease. In: Open Forum Infectious Diseases, Vol. 2, no. 2, p. ofv067-ofv067 (2015). doi:10.1093/ofid/ofv067.
Benoit, Anne ; Legrand, Catherine ; Dewé, Walthère. Influenza vaccine efficacy trials: a simulation approach to understand failures from the past. In: Pharmaceutical Statistics : the journal of applied statistics in the pharmaceutical industry, Vol. 14, no.4, p. 294-301 (2015). doi:10.1002/pst.1685.
Boscolo, Elisa ; Limaye, Nisha ; Huang, Lan ; Kang, Kyu-Tae ; Soblet, Julie ; Uebelhoer, Mélanie ; Mendola, Antonella ; Natynki, Marjut ; Seront, Emmanuel ; Dupont, Sophie ; Hammer, Jennifer ; Legrand, Catherine ; Brugnara, Carlo ; Eklund, Lauri ; Vikkula, Miikka ; Bischoff, Joyce ; Boon, Laurence. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. In: Journal of Clinical Investigation, Vol. 125, no. 9, p. 3491-3504 (2015). doi:10.1172/JCI76004.
Munda, Marco ; Legrand, Catherine ; Duchateau, Luc ; Janssen, Paul. Testing for decreasing heterogeneity in a new time-varying frailty model. In: Test, Vol. 25, no.4, p. 591-606 (2015). doi:10.1007/s11749-015-0468-9.
Munda, Marco ; Legrand, Catherine. Adjusting for centre heterogeneity in multicentre clinical trials with a time-to-event outcome. In: Pharmaceutical Statistics : the journal of applied statistics in the pharmaceutical industry, Vol. 13, no.2, p. 145-152 (2014). doi:10.1002/pst.1612.
Tromme, Isabelle ; Devleesschauwer, Brecht ; Beutels, Philippe ; Richez, Pauline ; LEROY, Laurence ; Baurain, Jean-François ; Cornelis, Frank ; BERTRAND, Claude ; Legrand, N ; Degueldre, Jérôme ; Thomas, Luc ; Legrand, Catherine ; LAMBERT, Julien ; Haagsma, J ; Speybroeck, Niko. Health-related quality of life in patients with melanoma expressed as utilities and disability weights. In: British Journal of Dermatology, Vol. 171, no.6, p. 1443-1450 (2014). doi:10.1111/bjd.13262.
Heuchenne, Cédric ; Laurent, Stéphane ; Legrand, Catherine ; Van Keilegom, Ingrid. Likelihood-Based Inference for Semi-Competing Risks. In: Communications in Statistics - Simulation and Computation, Vol. 43, no. 5, p. 1112-1132 (2014). doi:10.1080/03610918.2012.725495.
Desmet, Lieven ; Venet, D ; Doffagne, E ; Timmermans, Catherine ; Burzykowski, T ; Legrand, Catherine ; Buyse, M. Linear mixed-effects models for central statistical monitoring of multicenter clinical trials.. In: Statistics in Medicine, Vol. 33, no. 30, p. 5265-5279 (2014). doi:10.1002/sim.6294.
Tromme, Isabelle ; Devleesschauwer, Brecht ; Beutels, Philippe ; Richez, Pauline ; Praet, Nicolas ; Sacré, Laurine ; Marot, Liliane ; Van Eeckhout, Pascal ; Theate, Ivan ; Baurain, Jean-François ; Lambert, Julien ; Legrand, Catherine ; Thomas, Luc ; Speybroeck, Niko. Selective use of sequential digital dermoscopy imaging allows a cost reduction in the melanoma detection process: a belgian study of patients with a single or a small number of atypical nevi.. In: PLoS One, Vol. 9, no. 10, p. e109339 (2014). doi:10.1371/journal.pone.0109339.
Loeys, Tom ; Legrand, Catherine ; Schettino, Antonio ; Pourtois, Gilles. Semi-parametric proportional hazards models with crossed random effects for psychometric response times. In: British Journal of Mathematical and Statistical Psychology, Vol. 67, no.2, p. 304-327 (2014). doi:10.1111/bmsp.12020.
Rotolo, Federico ; Legrand, Catherine ; Van Keilegom, Ingrid. A simulation procedure based on copulas to generate clustered multi-state survival data. In: Computer methods and programs in biomedicine, Vol. 109, no. 3, p. 305-312 (2013). doi:10.1016/j.cmpb.2012.09.003.
Dewe, Walthere ; Benoît, Anne ; Legrand, Catherine. Assessing vaccine efficacy in influenza clinical trials: challenges and difficulties. In: Expert Review of Clinical Pharmacology, Vol. 6, no.4, p. 403-411 (2013). doi:10.1586/17512433.2013.811817.
Forget, Patrice ; Machiels, Jean-Pascal ; Coulie, Pierre ; Berlière, Martine ; Poncelet, Alain ; Tombal, Bertrand ; Stainier, Annabelle ; Legrand, Catherine ; Canon, Jean-Luc ; Kremer, Yann ; De Kock, Marc. Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery. In: Annals of Surgical Oncology, Vol. 20, no. Suppl 3, p. S650-660 (2013). doi:10.1245/s10434-013-3136-x.
Laurent, Stéphane ; Legrand, Catherine. A bayesian framework for the ratio of two poisson rates in the context of vaccine efficacy trials Journal. In: ESAIM: Probability & Statistics, Vol. 16, p. 375-378 (2012). doi:10.1051/ps/2010018.
Venet, David ; Doffagne, Erik ; Burzykowski, Tomasz ; Beckers, François ; Tellier, Yves ; Genevois-Marlin, Eric ; Becker, Ursula ; Bee, Valerie ; Wilson, Veronique ; Legrand, Catherine ; Buyse, Marc. A statistical approach to central monitoring of data quality in clinical trials. In: Clinical trials (London, England), Vol. 9, no. 6, p. 705-713 (2012). doi:10.1177/1740774512447898.
Tromme, Isabelle ; Sacré, L ; Hammouch, Fatima ; Legrand, Catherine ; Marot, Liliane ; Vereecken, Pierre ; Théate, Ivan ; van Eeckhout, Pascal ; Richez, Pauline ; Baurain, Jean-François ; Thomas, L ; Speybroeck, Niko ; DEPIMELA study group. Availability of digital dermoscopy in daily practice dramatically reduces the number of excised melanocytic lesions: results from an observational study. In: British Journal of Dermatology, Vol. 167, no. 4, p. 778-786 (2012). doi:10.1111/j.1365-2133.2012.11042.x.
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Thas, Olivier ; Thimpont, Joël ; Germonpré, Paul ; De Vuyst, Paul ; Bosquée, Lionel ; Legrand, Catherine ; Kellen, Eliane ; Kishi, Yoshiro ; Delanghe, Joris R ; van Meerbeeck, Jan P. The effect of clinical covariates on the diagnostic and prognostic value of soluble mesothelin and megakaryocyte potentiating factor. In: Chest, Vol. 141, no. 2, p. 477-484 (2012). doi:10.1378/chest.11-0129.
Munda, Marco ; Rotolo, Federico ; Legrand, Catherine. parfm: Parametric Frailty Models in R. In: Journal of Statistical Software, Vol. 51, no.11 (2012).
Forget, Patrice ; Tombal, Bertrand ; Scholtes, Jean-Louis ; Nzimbala, Jolio ; Meulders, Catherine ; Legrand, Catherine ; Van Cangh, Paul ; Cosyns, Jean-Pierre ; De Kock, Marc. Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer?. In: European Journal of Anaesthesiology, Vol. 28, no. 12, p. 830-835 (2011). doi:10.1097/EJA.0b013e32834b7d9a.
Ha, Il Do ; Sylvester, Richard ; Legrand, Catherine ; MacKenzie, Gilbert. Frailty modelling for survival data from multi-centre clinical trials. In: Statistics in Medicine, Vol. 30, no.17, p. 2144–2159 (July 2011). doi:10.1002/sim.4250.
Collée, Audrey ; Legrand, Catherine ; Govaerts, Bernadette ; Van Der Veken, Paul ; De Broodt, Franck ; Degrave, Etienne. Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population : a cross-sectional study. In: Noise & Health : a quarterly inter-disciplinary international journal, Vol. 13, no. 50, p. 64-70 (2011). doi:10.4103/1463-1741.73997.
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Gosselin, Robert ; De Wever, Walter ; Bosquée, Lionel ; De Vuyst, Paul ; Germonpré, Paul ; Kellen, Eliane ; Legrand, Catherine ; Kishi, Yoshiro ; Delanghe, Joris R ; van Meerbeeck, Jan P. Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma.. In: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 6, no. 11, p. 1930-7 (2011). doi:10.1097/JTO.0b013e3182272294.
Surmont, V. ; Aerts, J.G.J.V ; Van Klaveren, R.J. ; Tournoy, K. ; Tan, K.Y. ; Vernhout, R.M. ; Schmitz, P.I.M ; Legrand, Catherine ; Hoogsteden, H.C. ; van Meerbeeck, J.P.. A randomized phase II study comparing two schedules of the 21-day regime of Gemcitabine and Carboplatin in advanced NSCLC. In: Oncology, Vol. 78, no. 3/4, p. 267-270 (2010). doi:10.1159/000315733.
Camargo, C.A. ; Gurner, D. ; Smithline, H. ; Chapela, R. ; Fabbri, L. ; Green, S. ; Malice, M. ; Legrand, Catherine ; Dass, S.B. ; Knorr, B. ; Reiss, T.. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. In: Journal of Allergy and Clinical Immunology, Vol. 125, no. 2, p. 374-380 (2010). doi:10.1016/j.jaci.2009.11.015.
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Thimpont, Joel ; Germonpre, Paul ; Bosquee, Lionel ; De Vuyst, Paul ; Legrand, Catherine ; Kellen, Eliane ; Kishi, Yoshiro ; Delanghe, Joris R. ; van Meerbeeck, Jan P.. Diagnostic Performance of Soluble Mesothelin and Megakaryocyte Potentiating Factor in Mesothelioma. In: American Journal of Respiratory and Critical Care Medicine, Vol. 181, no. 6, p. 620-625 (2010). doi:10.1164/rccm.200907-1020OC.
Forget, Patrice ; Vandenhende, Julie ; Berlière, Martine ; Machiels, Jean-Pascal ; Nussbaum, Benoît ; Legrand, Catherine ; De Kock, Marc. Do intraoperative analgesics influence breast cancer recurrence after mastectomy? : A retrospective analysis. In: Anesthesia and Analgesia, Vol. 110, no. 6, p. 1630-1635 (2010). doi:10.1213/ANE.0b013e3181d2ad07.
Francart, Julie ; Vaes, Evelien ; Henrard, Séverine ; Legrand, Catherine ; Baas, P ; Gaafar, R. ; van Meerbeeck, J P ; Sylvester, Richard J. ; Robert, Annie. A prognostic index for progression-free survival in malignant mesothelioma with application to the design of phase II trials: A combined analysis of 10 EORTC trials.. In: European journal of cancer (Oxford, England : 1990), Vol. 45, no. 13, p. 2304-11 (2009). doi:10.1016/j.ejca.2009.04.028.
Legrand, Catherine ; Efficace, Fabio. Implementing patient-reported health-related quality-of-life data in cancer routine practice to improve accuracy of prognosis. Are we there yet?. In: Expert review of pharmacoeconomics & outcomes research, Vol. 9, no. 6, p. 493-6 (2009). doi:10.1586/erp.09.59.
Legrand, Catherine ; Duchateau, L. ; Janssen, P. ; Ducrocq, V. ; Sylvester, Richard J.. Validation of prognostic indices using the frailty model. In: Lifetime Data Analysis, Vol. 15, no. 1, p. 59-78 (2009). doi:10.1007/s10985-008-9092-2.
Komarek, Arnost ; Lesaffre, Emmanuel ; Legrand, Catherine. Baseline and treatment effect heterogeneity for survival times between centers using a random effects accelerated failure time model with flexible error distribution. In: Statistics in Medicine, Vol. 26, no. 30, p. 5457-5472 (2007). doi:10.1002/sim.3083.
Cortinas Abrahantes, Jose ; Legrand, Catherine ; Burzykowski, Tomasz ; Janssen, Paul ; Ducrocq, Vincent ; Duchateau, Luc. Comparison of different estimation procedures for proportional hazards model with random effects. In: Computational Statistics & Data Analysis, Vol. 51, no. 8, p. 3913-3930 (2007). doi:10.1016/j.csda.2006.03.009.
Surmont, V. ; Van Klaveren, R.J. ; Goor, C. ; Schramel, F. ; Manegold, C. ; Legrand, Catherine ; Van Schil, P. ; Van Meerbeeck, J.P.. Lessons to learn from EORTC study 08981: A feasibility study of induction chemoradiotherapy followed by surgical resection for stage IIIB non-small cell lung cancer. In: Lung Cancer, Vol. 55, no.1, p. 95-99 (January 2007). doi:10.1016/j.lungcan.2006.09.015.
Belderbos, José ; Uitterhoeve, Lon ; van Zandwijk, Nico ; Belderbos, Huub ; Rodrigus, Patrick ; van de Vaart, Paul ; Price, Allan ; van Walree, Nico ; Legrand, Catherine ; Dussenne, Sonia ; Bartelink, Harry ; Giaccone, Giuseppe ; Koning, Caro. Randomised trial of sequential versus concurrent chemo-radiotherapy in patients with inoperable non-small cell lung cancer (EORTC 08972-22973). In: European Journal of Cancer, Vol. 43, no.1, p. 114–121 (January 2007). doi:10.1016/j.ejca.2006.09.005.
van Meerbeeck, Jan P. ; Kramer, Gijs w.P.M. ; Van Schil, Paul E. Y. ; Legrand, Catherine ; Smit, Egbert F. ; Schramel, Franz ; Tjan-Heijnen, Vivianne ; Biesma, Bonne ; Debruyne, Channa ; van Zandwijk, Nico ; Splinter, Ted A.W. ; Giaccone, Giuseppe. Randomized Controlled Trial of Resection Versus Radiotherapy After Induction Chemotherapy in Stage IIIA-N2 Non–Small-Cell Lung Cancer. In: Journal of the National Cancer Institute, Vol. 99, no.6, p. 442-450 (March 2007). doi:10.1093/jnci/djk093.
Philip, George ; Pearlman, David S. ; Villarán, César ; Legrand, Catherine ; Loeys, Tom ; Langdon, Ronald B. ; Reiss, Theodore. Single-Dose Montelukast or Salmeterol as Protection Against Exercise-Induced Bronchoconstriction. In: Chest : the cardiopulmonary and critical care journal, Vol. 132, no.3, p. 875-883 (Sept. 2007). doi:10.1378/chest.07-0550.
Bottomley, Andrew ; Coens, Corneel ; Efficace, Fabio ; Gaafar, Rabab ; Manegold, Christian ; Burgers, Sjaak ; Vincent, Mark ; Legrand, Catherine ; van Meerbeeck, Jan P.. Symptoms and patient-reported well-being: Do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma. In: Journal of Clinical Oncology, Vol. 25, no. 36, p. 5770-5776 (2007). doi:10.1200/JCO.2007.12.5294.
Biesma, Bonne ; Manegold, C. ; Smit, H.J.M ; Willems, L. ; Legrand, Catherine ; Passioukov, A. ; van Meerbeeck, J.P. ; Giaccone, Giuseppe. Docetaxel and cisplatin as induction chemotherapy in patients with pathologically-proven stage IIIA N2 non-small cell lung cancer: a phase II study of the European organization for research and treatment of cancer (EORTC 08984). In: European Journal of Cancer, Vol. 42, no.10, p. 1399-1406 (July 2006). doi:10.1016/j.ejca.2006.01.049.
Legrand, Catherine ; Duchateau, L. ; Sylvester, Richard J. ; Janssen, P. ; van der Hage, JA ; van de Velde, CJH ; Therasse, Patrick. Heterogeneity in disease free survival between centers: lessons learned from an EORTC breast cancer trial. In: Clinical Trials, Vol. 3, no. 1, p. 10-18 (2006). doi:10.1191/1740774506cn132oa.
Efficace, F ; Bottomley, A ; Smit, E. ; Lianes, P ; Legrand, Catherine ; Debruyne, C ; Schramel, F ; Smit, H. ; Gaafar, R ; Biesma, B ; Manegold, C ; Coens, C ; Giaccone, G ; Van Meerbeeck, J. Is a patient's self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975. In: Annals of Oncology, Vol. 17, no.11, p. 1698-1704 (2006). doi:10.1093/annonc/mdl183.
Francart, Julie ; Legrand, Catherine ; Sylvester, Richard ; Van Glabbeke, Martine ; van Meerbeeck, Jan P ; Robert, Annie. Progression-free survival rate as primary end point for phase II cancer clinical trials : application to mesothelioma--The EORTC Lung Cancer Group.. In: Journal of Clinical Oncology, Vol. 24, no. 19, p. 3007-12 (2006). doi:10.1200/JCO.2005.05.1359.
Kramer, G.W.P.M. ; Legrand, Catherine ; van Schil, Paul ; Uitterhoeve, Lon ; Smit, Egbert F. ; Schramel, Franz ; Biesma, Bonne ; Tjan-Heijnen, Vivianne ; van Zandwijk, Nico ; Splinter, Ted ; Giaccone, Giuseppe ; van Meerbeeck, Jan P.. Quality assurance of thoracic radiotherapy in EORTC 08941: A randomised trial of surgery versus thoracic radiotherapy in patients with stage IIIA non-small-cell lung cancer (NSCLC) after response to induction chemotherapy. In: European Journal of Cancer, Vol. 42, no.10, p. 1391–1398 (July 2006). doi:10.1016/j.ejca.2006.01.052.
Bottomley, Andrew ; Vincent, Marie-Françoise ; Gaafa, R ; Manegold, C. ; Burgers, S ; Coens, Corneel ; Legrand, Catherine ; Giaccone, Giuseppe ; van Meerbeeck, J.. Short-term treatment-related symptoms and quality of life: Results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study. In: Journal of Clinical Oncology, Vol. 24, no. 9, p. 1435-1442 (2006). doi:10.1200/JCO.2005.03.3027.
Legrand, Catherine. 1687Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials : Early Breast Cancer Trialists' Collaborative Group (EBCTCG). In: The Lancet, Vol. 365, no. 9472, p. 1687-1717 (2005). doi:10.1016/S0140-6736(05)66544-0.
Legrand, Catherine ; Ducrocq, V. ; Janssen, P. ; Sylvester, Richard J. ; Duchateau, L.. A Bayesian approach to jointly estimate centre and treatment by centre heterogeneity in a proportional hazards model. In: Statistics in Medicine, Vol. 24, no. 24, p. 3789-3804 (2005). doi:10.1002/sim.2475.
Scagliotti, Giorgio V. ; Smit, Egbert ; Bosquee, Lionel ; O'Brien, Mary ; Ardizzoni, Andrea ; Zatloukaf, Peter ; Eberhardt, Wilfried ; Smid-Geirnaerdt, Maartje ; de Bruin, Hein G. ; Dussenne, Sonia ; Legrand, Catherine ; Giaccone, Giuseppe. A phase II study of paclitaxel in advanced bronchioloalveolar carcinoma (EORTC trial 08956). In: Lung Cancer, Vol. 50, no. 1, p. 91-96 (2005). doi:10.1016/j.lungcan.2005.05.012.
Van Schil, P ; Van Meerbeeck, J ; Kramer, G ; Splinter, T ; Legrand, Catherine ; Giaccone, Giuseppe ; Manegold, C. ; van Zandwijk, N. Morbidity and mortality in the surgery arm of EORTC 08941 trial. In: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, Vol. 26, no. 2, p. 192-197 (2005). doi:10.1183/09031936.05.00127204.
Giaccone, Giuseppe ; Debruyne, Channa ; Felip, Enriqueta ; Chapman, Paul B. ; Grant, Stefan C. ; Millward, Michael ; Thiberville, Luc ; D'addario, Giannicola ; Coens, Corneel ; Rome, Lisa S. ; Zatloukal, Petr ; Masso, Oriol ; Legrand, Catherine. Phase III Study of Adjuvant Vaccination With Bec2/Bacille Calmette-Guerin in Responding Patients With Limited-Disease Small-Cell Lung Cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). In: Journal of Clinical Oncology, Vol. 23, no. 28, p. 6854-6864 (2005). doi:10.1200/JCO.2005.17.186.
van Meerbeeck, Jan P. ; Gaafar, Rabab ; Manegold, Christian ; Van Klaveren, Rob. J. ; Van Marck, Eric A. ; Vincent, Mark ; Legrand, Catherine ; Bottomley, Andrew ; Debruyne, Channa ; Giaccone, Giuseppe. Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma : An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. In: Journal of Clinical Oncology, Vol. 23, no. 28, p. 6881-6889 (2005). doi:10.1200/JCO.20005.14.589.
Kramer, Gijsbert W.P.M. ; Gans, Steven ; Ullmann, Eric ; van Meerbeeck, Jan P. ; Legrand, Catherine ; Leer, Jan-Willem H. Hypofractionated external beam radiotherapy as retreatment for symptomatic non–small-cell lung carcinoma : an effective treatment ?. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 58, no. 5, p. 1388-1393 (2004). doi:10.1016/j.ijrobp.2003.09.087.
van der Hage, JA ; van den Broek, LJCM ; Legrand, Catherine ; Clahsen, PC. ; Bosch, CJA ; Robanus-Maandag, EC ; van de Velde, CJH ; van de Vijver, MJ. Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients. In: The British journal of cancer, Vol. 90, no. 8, p. 1543-1550 (2004). doi:10.1038/sj.bjc.6601741.
O'Brien, M.E.R. ; Splinter, T. ; Smit, E.F. ; Biesma, Bonne ; Krzakowski, M. ; Tjan-Heijnen, V.c.G ; Van Bochove, A. ; Stigt, J. ; Smid-Geirnaerdt, M.J.A. ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. Carboplatin and paclitaxol (Taxol) as an induction regimen for patients with biopsy-proven stage IIIA N2 non-small cell lung cancer : an EORTC phase II study (EORTC 08958). In: European Journal of Cancer, Vol. 39, no. 10, p. 1416-1422 (2003). doi:10.1016/S0959-8049(03)00319-8.
Ardizzoni, A. ; Manegold, C. ; Debruyne, Channa ; Gaafar, R. ; Buchholz, E. ; Smit, E. F. ; Lianes, P. ; ten Velde, G. ; Bosquée, L. ; Legrand, Catherine ; Neumaier, C. ; King, K. ; Giaccone, Giuseppe. European Organization for Research and Treatment of Cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer. In: Clinical Cancer Research, Vol. 9, no. 1, p. 143-150 (2003).
Dziadziuszko, R. ; Ardizzoni, A ; Postmus, P.E. ; Smit, E.F. ; Price, A ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases : a phase II study of the EORTC Lung Cancer Group (08965). In: European Journal of Cancer, Vol. 39, no. 9, p. 1271-1276 (2003). doi:10.1016/S0959-8049(03)00234-X.
Baas, P. ; Ardizzoni, A. ; Grossi, F. ; Nackaerts, K. ; Numico, G. ; Van Marck, E. ; van de Vijver, M. ; Monetti, F. ; Smid-Geirnaerdt, M.J.A. ; van Zandwijk, N. ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. The activity of raltitrexed (Tomudex®) in malignant pleural mesothelioma : an EORTC phase II study (08992). In: European Journal of Cancer, Vol. 39, no. 3, p. 353-357 (2003). doi:10.1016/S0959-8049(02)00668-8.
Smit, Egbert, F. ; van Meerbeeck, Jan P.A.M. ; Lianes, Pilar ; Debruyne, Channa ; Legrand, Catherine ; Schramel, Franz ; Smit, Hans ; Gaafar, Rabab ; Biesma, Bonne ; Manegold, Chris ; Neymark, Niels ; Giaccone, Giuseppe. Three-Arm Randomized Study of Two Cisplatin-Based Regimens and Paclitaxel Plus Gemcitabine in Advanced Non–Small-Cell Lung Cancer : A Phase III Trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group—EORTC 08975. In: Journal of Clinical Oncology, Vol. 21, no. 21, p. 3909-3917 (2003). doi:10.1200/JCO.2003.03.195..
Fentiman, IS ; Christiaens, MR. ; Paridaens, Robert ; Van Geel, A ; Rutgers, E ; Berner, J ; de Keizer, G ; Wildiers, J ; Nagadowska, M ; Legrand, Catherine ; Therasse, Patrick. Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy. In: European Journal of Cancer, Vol. 39, no. 3, p. 309-316 (2003). doi:10.1016/S0959-8049(02)00673-1.
Ardizzoni, Andrea ; Tjan-Heijnen, Vivianne C. G. ; Postmus, Pieter E. ; Buchholz, Erica ; Biesma, Bonne ; Karnicka-Mlodkowska, Hanna ; Dziadziusko, Rafal ; Burghouts, Jos ; Van Meerbeeck, Jan P. ; Gans, Stevens ; Legrand, Catherine ; Debruynne, Channa ; Giaccone, Giuseppe. Standard Versus Intensified Chemotherapy With Granulocyte Colony-Stimulating Factor Support in Small-Cell Lung Cancer : A Prospective European Organization for Research and Treatment of Cancer–Lung Cancer Group Phase III Trial—08923. In: Journal of Clinical Oncology, Vol. 20, no. 19, p. 3947-3955 (2002). doi:10.1200/JCO.2002.02.069.
Sylvester, R ; Van Glabbeke, M ; Collette, L ; Suciu, S ; Baron, B ; Legrand, Catherine ; Gorlia, T ; Collins, G ; Coens, C ; Declerck, L ; Therasse, P. Statistical methodology of phase III cancer clinical trials: advances and future perspectives. In: European Journal of Cancer, Vol. 38, p. 162-168 (2002). doi:10.1016/S0959-8049(01)00442-7.
Duchateau, Luc ; Janssen, Paul ; Lindsey, Patrick ; Legrand, Catherine ; Nguti, Rosemary ; Sylvester, Richard J.. The shared frailty model and the power for heterogeneity tests in multicenter trials. In: Computational Statistics & Data Analysis, Vol. 40, no. 3, p. 603-620 (2002). doi:10.1016/S0167-9473(02)00057-9.
Legrand, Catherine ; Sylvester, Richard J. ; Duchateau, L. ; Janssen, P. ; Therasse, Patrick. Treatment outcome studies: pitfalls in current methods and practice. In: European Journal of Cancer, Vol. 38, no. 9, p. 1173-1180 (2002). doi:10.1016/S0959-8049(02)00085-0.
Baron, Benoit ; Legrand, Catherine ; Levi, F. ; Hoctin-Boes, G.. Chronomodulation: optimal time finding design. In: Controlled Clinical Trials, Vol. 22, no. suppl. 1, p. S59-S60 (2001). doi:10.1016/S0197-2456(01)00130-1.
Van Der Hage, J.A. ; Robanus, E. ; van den Broeck, L.J.C.M. ; Bosch, C. ; van de Velde, C.J.H. ; Clahsen, P. ; Legrand, Catherine ; Duchateau, L. ; van de Vijver, M.J.. Prognostic significance of PS6K in node-negative premenopausal breast cancer patients. In: European Journal of Cancer, Vol. 37, no. suppl. 6, p. S269 (April 2001). doi:10.1016/S0959-8049(01)81485-4.
Stallenberg, Bernard ; Rommens, Jacques ; Legrand, Catherine ; de Maertelaer, Viviane ; Metens, Thierry ; Genevois, Pierre Alain. Radiographic diagnosis of rotator cuff tear based on the supraspinatus muscle radiodensity. In: Skeletal Radiology : journal of radiology, pathology and orthopedics, Vol. 30, no. 1, p. 31-38 (2001). doi:10.1007/s002560000301.
Tjan-Heijnen, V.C.G. ; Postmus, P.E. ; Ardizzoni, A. ; Manegold, Ch. ; Burghouts, J. ; van Meerbeeck, J. ; Mollers, M. ; Gans, S. ; Buchholz, E. ; Biesma, Bonne ; Legrand, Catherine ; Debruyne, C. ; Giaccone, Giuseppe. Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients : an EORTC double-blind placebo-controlled phase III study. In: Annals of Oncology, Vol. 12, no. 10, p. 1359-1368 (2001). doi:10.1023/A:1012545507920.
Ardizzoni, A ; Manegold, C ; Debruyne, C ; Gaafar, R ; Buchholz, E ; Dussenne, S ; Legrand, Catherine ; King, K ; Giaccone, Giuseppe. EORTC LCCG Phase II study of topotecan in combination with cisplatin as second line chemotherapy of sensitive and refractory small cell lung cancer (SCLC). In: Lung Cancer, Vol. 29, no. suppl. 1, p. 51 (suppl. 2000). doi:10.1016/S0169-5002(00)80166-X.
van Dongen, Joop A. ; Voogd, Adri C. ; Fentiman, Ian S. ; Legrand, Catherine ; Sylvester, Richard J. ; Tong, David ; van der Schueren, Emmanuel ; Helle, Peter A. ; van Zijl, Kobus ; Bartelink, Harry. Long-Term Results of a Randomized Trial Comparing Breast-Conserving Therapy With Mastectomy : European Organization for Research and Treatment of Cancer 10801 Trial. In: Journal of the National Cancer Institute, Vol. 92, no. 14, p. 1143-1150 (2000). doi:10.1093/jnci/92.14.1143.
Legrand, Catherine. Assessing Heterogeneity in Clinical Trials Using the Frailty Model : Quantifying, interpreting and explaining heterogeneity over centers in multicenter cancer clinical trials, VDM Verlag Dr. Müller e.K., 2009. 978-3-639-21334-8. 188 p.
Gagliolo, M. ; Legrand, Catherine. Algorithm survival analysis. In: Thomas Bartz-Beielstein, Marco Chiarandini, Luís Paquete, Experimental Methods for the Analysis of Optimization Algorithms, Springer, 2010, p. 161-184. 978-3-642-02537-2.
Fusaro, Fabio ; Benoît, Anne ; De Meyer, Martine ; De Pauw, Luc ; Patrono, D. ; Chaïb-Eddour, D. ; Goffin, Eric ; Kanaan, Nada ; Pirson, Yves ; Legrand, Catherine ; Mourad, Michel. Living donor kidney transplantation in a single center : 45 years’experience. American Society of Nefrology - Kidney Week ((United States) Philadelphia, PA, du 30/04/2011 au 04/05/2011). In: American Journal of Transplantation, Vol. 11, no. Suppl 2, p. 512 (2011).
Hollevoet, K. ; Van Cleemput, J. ; Thimpont, J. ; De Vuyst, P. ; Bosquée, L. ; Nackaerts, Kristiaan ; Kishi, Y. ; Legrand, Catherine ; Delanghe, J. R. ; van Meerbeeck, J. P.. Follow-up of Asbestos-exposed Individuals Using Mesothelioma Serum Biomarkers. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 5, no. 5, p. S106-S106 (2010).
Hollevoet, K. ; Nackaerts, Kristiaan ; Thimpont, J. ; Germonpre, P. ; De Vuyst, P. ; Bosquée, L. ; Legrand, Catherine ; Yoshiro, K. ; Delanghe, J. ; van Meerbeeck, J.. Diagnostic performance of soluble mesothelin and megakaryocyte potentiating factor as biomarkers of mesothelioma. Annual Meeting of the EORTC/NCI/ASCO on Molecular Markers in Cancer (Brussels(Belgium), Oct 15-17, 2009). In: EJC - Supplements, Vol. 7, no. 4, p. 9 (2009).
Gagliolo, M. ; Legrand, Catherine ; Birattari, M.. Mixed-effects modeling of optimisation algorithm performance. Engineering Stochastic Local Search Algorithms. Designing, Implementing and Analyzing Effective Heuristics. Second International Workshop, SLS 2009 (Brussels, Belgium, du 03/09/2008 au 04/09/2008). In: Engineering Stochastic Local Search Algorithms. Designing, Implementing and Analyzing Effective Heuristics. Second International Workshop, SLS 2009 (Lecture Notes in Computer Science; 5752), Springer verlag, 2009. 978-3-642-03750-4, p. 150-154.
Hollevoet, Kevin ; Kellen, Eliane ; Nackaerts, Kristiaan ; Bosquee, Lionel ; Germonpre, Paul ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Soluble mesothelin as a monitoring tool in the management of malignant mesothelioma patients. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S761-S762 (2009). doi:10.1097/JTO.0b013e3181a1084f.
Hollevoet, Kevin ; Van Cleemput, Joris ; Thimpont, Joel ; Vandeweerdt, Marc ; De Vuyst, Paul ; Nackaerts, Kristiaan ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Soluble mesothelin as a tool for early detection of malignant mesothelioma in asbestos-exposed workers. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S458-S458 (2009).
Hollevoet, Kevin ; Kellen, Eliane ; Nackaerts, Kristiaan ; Thimpont, Joel ; Germonpre, Paul ; De Vuyst, Paul ; Bosquee, Lionel ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Validation of soluble mesothelin: design and preliminary results of a Belgian multicentric observational study. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S345-S345 (2009).
Legrand, Catherine. Induction chemotherapy (CT) in stage IIIA-N2 non-small cell lung cancer (NSCLC): An analysis of different regimens used in EORTC 08941. 10th World Conference on Lung Cancer (Vancouver, Canada, du 10/08/2003 au 14/08/2003). In: Lung Cancer, Vol. 41, no. suppl. 2, p. S79-S80 (2003). doi:10.1016/S0169-5002(03)91931-3.
Legrand, Catherine. Surgery after induction chemotherapy: Morbidity and mortality in the first 100 patients of the surgery arm of EORTC 08941 trial. 10th World Conference on Lung Cancer (Vancouver, Canada, du 10/08/2003 au 14/08/2003). In: Lung Cancer, Vol. 41, no. suppl. 2, p. S45 (2003). doi:10.1016/S0169-5002(03)91805-8.
Denuit, Michel ; Legrand, Catherine ; Haine, Luc ; Segers, Johan. Rapport d'autoévaluation des cursus en mathématique, sciences actuarielles, statistique et biostatistique, 2018.
Bertrand, Aurélie ; Van Keilegom, Ingrid ; Legrand, Catherine. Flexible parametric approach to classical measurement error variance estimation without auxiliary data (ISBA Discussion Paper; 2017/25), 2017. 28 p.
Scolas, Sylvie ; Legrand, Catherine ; Oulhaj, Abderrahim ; El Ghouch, Anouar. Diagnostic checks in mixture cure models with interval-censoring (ISBA Discussion Paper; 2016/14), 2016. 27 p.
Denuit, Michel ; Legrand, Catherine. Risk Classification in Life Insurance: Extension to Continuous Covariates (ISBA Discussion Paper; 2016/45), 2016. 6 p.
Bertrand, Aurélie ; Legrand, Catherine ; Léonard, Daniel ; Van Keilegom, Ingrid. Robustness of estimation methods in a survival cure model with mismeasured covariates (ISBA Discussion Paper; 2016/06), 2016. 31 p.
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine. The SNP representation in mixture cure models with interval-censoring: estimation and goodness-of-fit testing (ISBA Discussion Paper; 2016/49), 2016. 23 p.
Bertrand, Aurélie ; Legrand, Catherine ; Carroll, Raymond J. ; de Meester de Ravenstein, Christophe ; Van Keilegom, Ingrid. Inference in a Survival Cure Model with Mismeasured Covariates using a SIMEX Approach (ISBA Discussion Paper; 2014/34), 2014. 30 p.
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine ; Oulhaj, Abderrahim. Variable selection in a flexible parametric mixture cure model with interval-censored data (ISBA Discussion Paper; 2014/41), 2014. 25 p.
Munda, Marco ; Legrand, Catherine. A diagnostic plot for guiding the choice of the frailty distribution in clustered survival data (ISBA Discussion Paper; 2013/37), 2013. 21 p.
Munda, Marco ; Legrand, Catherine. Adjusting for centre differences in multicentre clinical trials: a simulation-based investigation for time-to-event outcomes (ISBA Discussion Paper; 2013/36), 2013. 21 p.
Dewé, Walthère ; Benoît, Anne ; Legrand, Catherine. Assessing Vaccine Efficacy in Influenze Clinical Trials - Challenges and Difficulties (ISBA Discussion Paper; 2013/21), 2013. 20 p.
Loeys, Tom ; Legrand, Catherine ; Schettino, Antonio. Semi-parametric proportional hazards models with crossed random effects for psychometric response times (ISBA Discussion Paper; 2013/42), 2013.
Munda, Marco ; Legrand, Catherine ; Duchateau, Luc ; Janssen, Paul. Testing for Decreasing Heterogeneity Between Hospitals in Time to Death from Chronic Myeloid Leukemia (ISBA Discussion Paper; 2013/55), 2013. 20 p.
Legrand, Catherine ; Munda, Marco ; Janssen, P. ; Duchateau, L.. A general class of time-varying coefficients models for right censored data (ISBA Discussion Paper; 2012/41), 2012. 41 p.
Forget, P. ; Machiels, J-P. ; Coulie, Pierre ; Berlière, M. ; Poncelet, A. ; Tombal, P. ; Stainier, A. ; Legrand, Catherine ; Canon, J-L. ; Kremer, Y. ; De Kock, M.. Neutrophil: lymphocyte ratio and intraoperative use of ketorolac or diflofenac are prognostic factors in breast, lung and kidney cancer surgery (ISBA Discussion Paper; 2012/40), 2012.
Munda, Marco ; Rotolo, Federico ; Legrand, Catherine. parfm: Parametric Frailty Models in R (ISBA Discussion Paper; 2012/05), 2012. 20 p.
Heuchenne, Cédric ; Laurent, Stéphane ; Legrand, Catherine ; Van Keilegom, Ingrid. Likelihood based inference for semi-competing risks (ISBA Discussion Paper; 2011/22), 2011. 26 p.
Rotolo, Federico ; Legrand, Catherine ; Van Keilegom, Ingrid. Simulation of clustered multi-state survival data based on a copula model (ISBA Discussion Paper; 2011/40), 2011. 20 p.
Collée, A. ; Legrand, Catherine ; Govaerts, Bernadette ; Van der Veken, P. ; De Boodt, V. ; Degrave, E. Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population : a cross-sectional study (ISBA Discussion Paper; 1004), 2010.
Meyer, N. ; Legrand, Catherine ; Giaccone, Giuseppe. Samples sizes in oncology trials : a survey (ISBA Discussion Paper; 1005), 2010.
Laurent, Stéphane ; Legrand, Catherine. A Bayesian framework for the ratio of two Poisson rates in the context of vaccine efficacy trials (STAT Discussion Paper; 0911), 2009. 26 p.
Surmont, V. ; Aerts, J. ; Van Klaveren, R.J. ; Tournoy, K. ; Tan, K. ; Vernhout, R.M. ; Schmitz, P.I.M. ; Legrand, Catherine ; Hoogsteden, H.C. ; Van Meerbeeck, J.P.. A randomized phase II study comparing two schedules of the 21-day regime of Gemcitabine and Carboplatin in advanced NSCLC (STAT Discussion Paper; 0927), 2009.
Hollevoet, K. ; Kellen, E. ; Thimpont, J. ; Germonpré, P. ; De Vuyst, P. ; Bosquée, L. ; Legrand, Catherine ; Kishi, Y. ; Nackaerts, K. ; Delanghe, J.R. ; Van Meerbeeck, J.P.. Diagnostic performance of soluble mesothelin and megakaryocyte potentiating factor as biomarkers of mesothelioma (STAT Discussion Paper; 0928), 2009.
Meyer, Nicolas ; Legrand, Catherine ; Giaccone, Giuseppe. Sample size in randomized clinical trials in oncology: usefull basic statistical knowledge for the clinician (STAT Discussion Paper; 0929), 2009.

References: V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V.