Source: http://www.asmscience.org/content/book/10.1128/9781555815547.ch31
Timestamp: 2019-04-26 06:27:50+00:00

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Overview of lipid biosynthetic pathways. Carbon sources are converted to pyruvate, which is subsequently converted to acetylCoA. Acetyl-CoA enters lipid biosynthesis via the action of acetylCoA carboxylase (ACC). Fatty acid biosynthesis proceeds through the action of either type I (FASI) or dissociated type II (FASII) systems. The resulting acyl groups are subsequently attached on the glycerol-3-phosphate backbone either via an acyl phosphate intermediate or through the action of specific acyltransferases. PtdOH is distributed between CDP-DAG and DAG. CDP-DAG and DAG are converted mainly to phospholipids via the action of phospholipid synthases. Excess DAG is diverted towards TAG. TAGs can also be derived from phospholipids via the action of PDAT. Abbreviations: MAT; malonyl-CoA:acyl-carrier-protein transacylase; TES, acyl-acyl carrier protein thioesterase; CDS, CDP-diacylglycerol synthetase; PLS, phospholipid synthases (referring to a variety of enzymes utilizing CDP-DAG and/or DAG for phospholipid synthesis); FFA, free fatty acids; PL, phospholipid. See the text for other abbreviations.
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