Source: https://iitbhu.ac.in/dept/phe/people/ksairamphe
Timestamp: 2019-04-18 15:20:58+00:00

Document:
Pharmacology, Neuroscience and Mitochondrial medicine.
2002- 2005 Postdoctoral Scholar, College of Pharmacy, University of Kentucky, Lexington, KY. U.S.A.
2005 Postdoctoral Fellow, Spinal cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Chandler Medical Center, Lexington, U.S.A.
2006 Scientist-I, Spinal cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Chandler Medical Center, Lexington, KY. U.S.A.
2006-2009 Reader in Pharmacology, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India.
2009-2018 Associate Professor, Department of Pharmaceutics, Indian Institute of Technology, (Banaras Hindu University), Varanasi-221005,India.
Pandey A, Joshi A, Mishra S, Krishnamurthy S, Hemalatha S (2018) Antinociceptive, anti inflammatory and antiarthritic activity of ethanol root extract and fraction of Aganosma dichotoma (Roth) K. Schum. Indian J Exp Biol. Vol.56(09) [September 2018]. http://nopr.niscair.res.in/handle/123456789/44999.(IF-1.475).
Kushwah S, Kumar A, Basu S, Krishnamurthy S, Kumar A (2017) Comparison of cerebrospinal fluid Cytochrome-c and Caspase-9 as biomarkers for newborns with hypoxic ischemic encephalopathy with non-asphyxiated babies and follow up of these biomarkers after day 7. International Journal of Research in Medical Sciences 3 (8), 2034-2040.
Kumar M, Prasad SK, Krishnamurthy S, Hemalatha S., (2014) Antihyperglycemic Activity of HouttuyniacordataThunb. inStreptozotocin-Induced Diabetic Rats. Advances in pharmacological sciences.
Sahu Alakh N, Hemalatha S, Sairam K. (2014) Phyto-pharmacological review of mesuaferrea linn. International Journal of Phytopharmacology, 5(1), 6-14.
Sahu A, Hemalatha S and Krishnamurthy S. (2013) Quality control studies of Argyreiaspeciosa sweet leaves. Int. J. Res. Ayurveda Pharm. 4(4), July-Aug, 495-498.
Sahu A, Hemalatha S and Krishnamurthy S. (2013) HPTLC fingerprinting and in vitro antioxidant studies of Argyreiaspeciosa sweet leaves and mesuaferrealinn. flowers. Int. J. Res. Ayurveda Pharm. 4(4), July-Aug, 499-502.
Sahu A, Hemalatha S and Krishnamurthy S. (2013). Quality Control Studies of MesuaferreaLinn. Flowers. International Journal of Herbal Medicine. 1(2), 124-130.
Sahu A, Hemalatha S, Krishnamurthy S. (2013) Gastric-ulcer protective activity of argyreiaspeciosasweet leaves) International Journal of Biological & Pharmaceutical Research. 2013; 4(12): 1182-1186.
Sahu A, Hemalatha S, Krishnamurthy S. (2013) Quantitative Phytochemical and Heavy Metal Estimation of MesuaferreaFlowers and ArgyreiaspeciosaLeaves Int. J. Pharm. Sci. Rev. Res., 22(2), Sep – Oct 2013( 49), 276-278.
Patel DK, . Kumar R, Krishnamurthy, S Hemalatha S. (2013) Advances in Plant Pharmacology of Hemiphyllum. Chinese Natural Medicine 03,004.
Patel D. K., Kumar R., Krishnamurthy S., S. Hemalatha. (2012) Aphrodisiac activity of ethanolic extract of Pedalium murex Linn fruit. Asian Pacific Journal of Tropical Biomedicine, (2012) Asian Pacific Journal of Tropical Biomedicine, S1568-S1571.
Patel D. K., Kumar R., Kumar M., Krishnamurthy S, Hemalatha S. (2012) Evaluation of aldose reductase inhibitory potential of different fraction of Hybanthusenneaspermuslinn f. muell. Asian Pacific Journal of Tropical Biomedicine, 2(2): 134-139.
Kumar R, Patel DK, Prasad SK Krishnamurthy S,Hemalatha S. (2012) Antidiabetic activity of alcoholic root extract of Caesalpiniadigynain streptozotocin-nicotinamide induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine S934-S940.
Evaluation of glucose utilization capacity of bioactivity guided fractions of Hybanthusenneaspermus and Pedalium murex in isolated rat hemidiaphragm. Journal of Acute Disease 2 (1), 33-36.
Laloo D, Kumar M, Prasad SK, Krishnamurthy S, S Hemalatha (2012) Gastroprotective activity of the alcoholic root extract of Potentilla fulgens wall. Reviews on clinical pharmacology and medicinal therapy.(10) 2.
Patel DK, Kumar R, Prasad SK, Krishnamurthy S, Hemalatha S. (2011) Antidiabetic and in vitro antioxidant potential of Hybanthusenneaspermuslinn f. muell in streptozotocin-induced-diabetic rats. Asian Pacific Journal of Tropical Biomedicine 316-322.
Kumar R. Patel, D. K,.Laloo D, Krishnamurthy S, Hemalatha S. (2011) Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens an in vitro study. Asian Pacific Journal of Tropical Medicine, 4, ( 9), September, Pages 694-697.
Patel D.K., Kumar R, Krishnamurthy S., Hemalatha S. (2011) Aldose reductase inhibitory activity of alcoholic extract of Pedalium murex Linn. Asian Pac J Trop Biomed, 2, (1), Supplement, January, S265–S269.
SahuAlakh N, Hemalatha S, Krishnamurthy S, Laloo D.and Patra A. (2010) Quality Control Studies of Ochrocarpuslongifolius Flower Buds. PHCOG J February ;Pharmacognosy Journal2 (6) ,118-123.
Sahu A N, Hemalatha S, Krishnamurthy S. (2010) Phytochemical quantitative estimation and pesticide residue determination of Mesua ferreaflowers. Journal of Medicinal and Aromatic Plant Sciences 32 (4) 187-192.
Goel R K, Sairam K, Dorababu M, Prabha T and Rao Ch V (2005) Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian J Exp Biol 43:715-721.
Datla GK, Sairam K, Priyambada S, Debnath PK and Goel RK (2002) Antiulcerogenic activity of Satavari mandur-an Ayurvedic herbo-mineral preparation. Indian J Exp Biol40:1173-1177.
Rao Ch V, Sairam K and Goel RK (2001) Experimental evaluation of Emblica officinalis fruit on gastric ulcers and mucosal offensive and defensive factors in rats. Acta Pharmaceutica Turcica XLIII: 155-160.
Sairam K, Rao Ch V and Goel RK (2001) Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J Exp Biol 39:350-354.
Bhattacharya SK, Bhattacharya A, Das K, Muruganantham AV and Sairam K (2001) Further investigations on the antioxidant activity of Ocimum sanctum using different paradigms of oxidative stress in rats. Natural Remedies 1:1-13.
Sairam K, Rao Ch V and Goel RK (2001) Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J Exp Biol 39:137-142.
Goel RK, Sairam K, Rao Ch V and Raman A (2001) Role of gastric antioxidant and anti-H.pylori activities in the antiulcerogenic activity of plantain banana (Musa sapientum Linn var. paradisiaca). Indian J Exp Biol 39:719-722.
Rao Ch. V, Sairam K and Goel RK (2000) Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Indian J Physiol Pharmacol 44: 435-441.
Agrawal AK, Rao Ch.V, Sairam K, Joshi VK and Goel RK (2000) Effect of Piper longum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats. Indian J Exp Biol 38:994-998.
Sairam K, Rao Ch V and Goel RK (2000) Effect of Ocimum sanctum Linn on peptic ulcers and gastric mucosal offensive and defensive factors. Biomedicine 20:260-267.
Goel RK and Sairam Krishnamurthy (2001) Antiulcer drugs from indigenous sources with emphasis on Musa sapientum, tamrabasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol 34:100-110.
Sairam Krishnamurthy, Rao Ch V and Goel RK . 1999. Drug Prescription in Elderly. Journal of Internal Medicine of India 2:288-291.
Sairam K and Sailaja Vani Batchu (2003) Treatment of Gastroduodenal ulcers: An Ayurvedic Perspective. In: Scientific Basis of Ayurvedic Therapy, Misra LK (editor), CRC press California, USA: pp.393-410.
Debapriya Garabadu and Sairam Krishnamurthy (2013) Temporal Effect of Repeated Stress on Type-2 Experimental Diabetes In: Diabetes Mellitus and Human Health Care A Holistic Approach to Diagnosis and Treatment.Editors: Anne George, MD., Robin AugustineandMathew Sebastian, MD(eds), Apple Academic Press Inc, USA: Chapter 9.
Project Title: “Phytochemical Standardization and Pharmacological Evaluation of Some Potential Anti-Gastroduodenal Ulcer Plants”.
Principal Investigator: Dr. A.N. Sahu, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University).
Sponsor: AICTE (Govt. of India) , 2007-2009.
Project Title: “Pharmacological Evaluation of Atypical Anti-psychotics for Anti-Post Traumatic Stress Disorder Activity in Rodent Models”.
Co- Principal Investigator: Prof.K.P.Joy, Department of Zoology, Banaras Hindu University.
Sponsor: CSIR (Govt. of India), 2009-2012..
Project Title “Experimental and clinical basis of novel treatment strategy using mitochondrial modulators in neonatal anoxic injury”.
Co-Principal Investigators: Prof. Ashok Kumar, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, and Prof. Gopeshwar Narayan, Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India.
Sponsor: DBT (Govt. of India); 2012-16.
Co- Principal Investigators: Prof.R.S. Srivastava, Prof. S.Hemalatha, Dr.Senthil Raja A ., Dr.A.N.Sahu, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University).
Sponsor: Faculty-grant- Indian Institute of Technology (Banaras Hindu University), 2016.
Project Title: “Experimental Evaluation of Geroprotective Activity of Some Compounds”.
Project Title: “Evaluation of some compounds in experimental Alzheimer’s Disease” .
Project Title: “Pharmacological effect of novel formulation in experimental allergic encephalomyelitis rodent model”.
Sponsor: M/S Disto Pharmaceuticals Pvt. Ltd. India. 2016.
Project Title: “Pharmacology of Natural Drugs in Obesity and Eating Disorders”.
“2,6-Disubstituted Piperidines and Pierazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin , Marlon D. Jones, Dennis K. Miller, Seth D. Norholm, Guangrong Zheng and Sairam Krishamurthy, U.S. Patent Application No. 10/813,647, March 31st, 2004.
“2, 6-Disubstituted Piperidines and Piperazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Dennis K. Miller, Seth D. Norholm, Sairam Krishnamurthy and Marlon D. Jones, U.S. Patent No. 7,368,443, May 6th, 2008.
“An Oral Composition Of Indole-3-Carbinol and A Method Of Preparation Thereof” by Sairam Krishnamurthy , Pankaj Paliwal and Gaurav Chauhan. Indian Patent filed on July 28, 2017, Application No. 201711026941.
“An Oral Bioactive Glass Formulation Containing Aqueous Micronized Barium Oxide for Treating Gastro-Duodenal Ulcers” by Sairam Krishnamurthy, Pankaj Paliwal and Sampath Kumar Arepalli. Indian Patent filed on September 8, 2017, Application No. 201711031854.
“A Bioactive Glass Based Formulation for Treating Cerebral Ischemic Reperfusion Injury And Method Thereof” by Sairam Krishnamurthy and Pankaj Paliwal. Indian Patent filed on September 11, 2017, Application No. 201711032099.
“A Bioactive Glass Scaffold and A Method of Preparation Thereof” by Sairam Krishnamurthy, Pankaj Paliwal, Shreyasi Majumdar and Sampath Kumar Arepalli. Indian Patent filed on 6th oct2017. Application No. 201711035474.
“A Novel Formulation of Dabigatran Solid Dispersion Formulation and a Method of Preparation Thereof” by Sairam Krishnamurthy, Pankaj Paliwal. Indian Patent filed on 3rd August 2018. Application No. 201811029316.
“A novel barium bioactive glass (BaBG) formulation and a method thereof” by Sairam Krishnamurthy, Pankaj Paliwal and Smriti Gupta Indian Patent filed on September 10, 2018, under Application No. 201811033966.
Development of a chronic model for PTSD for pharmacological evaluation of experimental drugs.
Fields of research: Post-traumatic stress disorder, Parkinson’s disease, Alzheimer’s disease, Multiple sclerosis, Cerebral Ischemia, Neonatal Anoxia and circadian rhythm disorders.
Characterization of mitochondria as a target for PTSD in animal models.
Role of GABA receptors as alternate targets for treatment of type2 diabetes mellitus.
Characterization of mitochondria as a target for neonatal asphyxia.
Alternative mechanism of action of selective serotonin reuptake inhibitors.
Glucocerobosidase as a target for Parkinson’s disease.
Collaborative research on development of compounds for treatment of Alzheimer’s disease. .
Development and validation of inorganic biomaterials for pharmacological use.
Pharmacological evaluation of Indian traditional drugs.

References: Application No. 10
 Application No. 201711026941
 Application No. 201711031854
 Application No. 201711032099
 Application No. 201711035474
 Application No. 201811029316
 Application No. 201811033966