Source: http://beutlerlab.org/publications.html
Timestamp: 2019-04-25 08:09:17+00:00

Document:
D. Zhang, W. Tomisato, L. Su, L. Sun, J.H. Choi, Z. Zhang, K.W. Wang, X. Zhan, M. Choi, X. Li, M. Tang, J.M. Castro-Perez, S. Hildebrand, A. R. Murray, E.M.Y. Moresco, B. Beutler. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. PMID: 28607088.
L. Israel, Y. Wang, K. Bulek, E. Della Mina, Z. Zhang, V. Pedergnana, M. Chrabieh, N.A. Lemmens, V. Sancho-Shimizu, M. Descatoire, T. Lasseau, E. Israelsson, L. Lorenzo, L. Yun, A. Belkadi, A. Moran, L.E. Weisman, F. Vandenesch, F. Batteux, S. Weller, M. Levin, J. Herberg, A. Abhyankar, C. Prando, Y. Itan, W.J. van Wamel, C. Picard, L. Abel, D. Chaussabel, X. Li, B. Beutler, P.D. Arkwright, J.L. Casanova, A. Puel. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell 2017 168(5):789-800. PMID: 28235196.
J.H. Choi, K.W. Wang, D. Zhang, X. Zhan, T. Wang, C.H. Bu, C.L. Behrendt, M. Zeng, Y. Wang, T. Misawa, X. Li, M. Tang, X. Zhan, L. Scott, S. Hildebrand, A.R. Murray, E.M. Moresco, L.V. Hooper, B. Beutler. IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proc Natl Acad Sci U S A. 2017 Jan 30. PMID:28137874.
E. Turer, W. McAlpine, K.W. Wang, T. Lu, X. Li, M. Tang, X. Zhan, T. Wang, X. Zhan, C.H. Bu, A.R. Murray, Beutler B. Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A. 2017 Jan 30. PMID:28137860.
X. Li, T. Maretzky, J.M. Perez-Aguilar, S. Monette, G. Weskamp, S. Le Gall, B. Beutler, H. Weinstein, C.P. Blobel. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2/ADAM17-dependent proteolysis. J Cell Sci. 2017 Jan 19. PMID:28104813.
C. Viant, S. Guia, R.J. Hennessy, J. Rautela, K. Pham, C. Bernat, W. Goh, Y. Jiao, R. Delconte, M. Roger, V. Simon, F. Souza-Fonseca-Guimaraes, S. Grabow, G.T. Belz, B.T. Kile, A. Strasser, D. Gray, P.D. Hodgkin, B. Beutler, E. Vivier, S. Ugolini, N.D. Huntington. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med. 2017 Jan 5. PMID:28057804.
B. Beutler. Innate immunity and the new forward genetics. Best Pract Res Clin Haematol. 2016 Dec;29(4):379-387. PMID:27890263.
H. Shi, A. Murray, B. Beutler. Reconstruction of the Mouse Inflammasome System in HEK293T Cells. Bio Protoc. 2016 Nov 5;6(21). PMID:28516117.
Z. Zhang, E. Turer, X. Li, X. Zhan, M. Choi, M. Tang, A. Press, S.R. Smith, A. Divoux, E.M. Moresco, B. Beutler. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A. 2016 Oct 5. PMID:27708159.
C.J. Groß, R. Mishra, K.S. Schneider, G. Médard, J. Wettmarshausen, D.C. Dittlein, H. Shi, O. Gorka, P.A. Koenig, S. Fromm, G. Magnani, T. Ćiković, L. Hartjes, J. Smollich, A.A. Robertson, M.A. Cooper, M. Schmidt-Supprian, M. Schuster, K. Schroder, P. Broz, C. Traidl-Hoffmann, B. Beutler, B. Kuster, J. Ruland, S. Schneider, F. Perocchi, O. Groß. K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity. 2016 Sep 24. PMID:27692612.
B. Beutler. Finding New Components of the Mammalian Immune System.Rambam Maimonides Med 2016 Jul 28;7(3). PMID: 27487306.
J.Q. Wang, B. Beutler, C.C. Goodnow, K. Horikawa. Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. Blood 2016 Jun 25. [Epub ahead of print]. PMID: 27458005.
O.M. Siggs, A. Stockenhuber, M. Deobagkar-Lele, K.R. Bull, T.L. Crockford, B.L. Kingston, G. Crawford, C. Anzilotti, V. Steeples, S. Ghaffari, G. Czibik, M. Bellahcene, H. Watkins, H. Ashrafian, B. Davies, A. Woods, D. Carling, A. Yavari, B. Beutler, R.J. Cornall. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A 2016 Jun 14. [Epub ahead of print]. PMID:27303042.
Y. Wang, L. Su, M.D. Morin, B.T. Jones, L.R. Whitby, M.M. Surakattula, H. Huang, H. Shi, J.H. Choi, K.W. Wang, E.M. Moresco, M. Berger, X. Zhan, H. Zhang, D.L. Boger, B. Beutler. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A 113(7):E884-93, (2016). PMID:26831104.
H. Shi, Y. Wang, X. Li, X. Zhan, M. Tang, M. Fina, L. Su, D. Pratt, C.H. Bu, S. Hildebrand, S. Lyon, L. Scott, J. Quan, Q. Sun, J. Russell, S. Arnett, P. Jurek, D. Chen, V.V. Kravchenko, J.C. Mathison, E.M. Moresco, N.L. Monson, R.J. Ulevitch, B. Beutler. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol 17(3):250-8, (2016). PMID:26642356.
B. Beutler, C.A. Thaiss. Q&A: Chance encounters. Nature 526(7574):S59-60, (2015). PMID:26488245.
M.M. Simon, E.M. Moresco, K.R. Bull, S. Kumar, A.M. Mallon, B. Beutler, P.K. Potter. Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mamm Genome 26(9-10):486-500, (2015). PMCID: PMC4602060.
O.M. Siggs, D.L. Popkin, P. Krebs, X. Li, M. Tang, X. Zhan, M. Zeng, P. Lin, Y. Xia, M.B. Oldstone, R.J. Cornall, B. Beutler. Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci U S A 112(42):E5706-14, (2015). PMCID: PMC4620900.
L.A. Miosge, M.A. Field, Y. Sontani, V. Cho, S. Johnson, A. Palkova, B. Balakishnan, R. Liang, Y. Zhang, S. Lyon, B. Beutler, B. Whittle, E.M. Bertram, A. Enders, C.C. Goodnow, T.D. Andrews. Comparison of predicted and actual consequences of missense mutations. Proc Natl Acad Sci U S A 112(37):E5189-98, (2015). PMCID: PMC4577149.
L.F. Mager, C. Riether, C.M. Schürch, Y. Banz, M.H. Wasmer, R. Stuber, A.P. Theocharides, X. Li, Y. Xia, H. Saito, S. Nakae, G.M. Baerlocher, M.G. Manz, K.D. McCoy, A.J. Macpherson, A.F. Ochsenbein, B. Beutler, P. Krebs. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest 125(7):2579-91, (2015). PMCID:PMC4563674.
L. von Hertzen, B. Beutler, J. Bienenstock, M. Blaser, P.D. Cani, J. Eriksson, M. Farkkila, T. Haahtela, I. Hanski, M.C. Jenmalm, J. Kere, M. Knip, K. Kontula, M. Koskenvuo, C. Ling, T. Mandrup-Poulsen, E. von Mutius, M.J. Makela, T. Paunio, G. Pershagen, H. Renz, G. Rook, M. Saarela, O. Vaarala, M. Veldhoen, W.M. de Vos. Helsinki alert of biodiversity and health. Ann Med 47(3):218-25, (2015). PMID:25904094.
T. Wang, X. Zhan, C.H. Bu, S. Lyon, D. Pratt, S. Hildebrand, J.H. Choi, Z. Zhang, M. Zeng, K.W. Wang, E. Turer, Z. Chen, D. Zhang, T. Yue, Y. Wang, H. Shi, J. Wang, L. Sun, J. SoRelle, W. McAlpine, N. Hutchins, X. Zhan, M. Fina, R. Gobert, J. Quan, M. Kreutzer, S. Arnett, K. Hawkins, A. Leach, C. Tate, C. Daniel, C. Reyna, L. Prince, S. Davis, J. Purrington, R. Bearden, J. Weatherly, D. White, J. Russell, Q. Sun, M. Tang, X. Li, L. Scott, E.M. Moresco, G.M. McInerney, G.B. Karlsson Hedestam, Y. Xie, B. Beutler. Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A 112(5):E440-9, (2015). PMCID: PMC4321302.
P. Dosenovic, M. Adori, W.C. Adams, G.K. Pedersen, M. Soldemo, B. Beutler, G.B. Karlsson Hedestam. Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol 93(2):136-46, (2015). PMID:25310967.
M.J. Jiménez-Dalmaroni, C.M. Radcliffe, D.J. Harvey, M.R. Wormald, P. Verdino, G.D. Ainge, D.S. Larsen, G.F. Painter, R. Ulevitch, B. Beutler, P.M. Rudd, R.A. Dwek, I.A. Wilson. Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunol21(2):175-193, (2015). PMCID:PMC4392886.
G.K. Pedersen, M. Adori, S. Khoenkhoen, P. Dosenovic, B. Beutler, G.B. Karlsson Hedestam. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proc Natl Acad Sci U S A111(39):E4119-26, (2014). PMCID: PMC4191775.
S. Rommelaere, V. Millet, T.P. Vu Manh, T. Gensollen, P. Andreoletti, M. Cherkaoui-Malki, C. Bourges, B. Escaliere, X. Du, Y. Xia, J. Imbert, B. Beutler, Y. Kanai, B. Malissen, M. Malissen, A. Tailleux, B. Staels, F. Galland, P. Naquet. Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS One 9(8):e104925, (2014). PMCID: PMC4139292.
E. Colak, A. Leslie, K. Zausmer, E. Khatamzas, A.V. Kubarenko, T. Pichulik, S.N. Klimosch, A. Mayer, O. Siggs, A. Hector, R. Fischer, B. Klesser, A. Rautanen, M. Frank, A.V. Hill, B. Manoury, B. Beutler, D. Hartl, A. Simmons, A.N. Weber. RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events. J Immun 192(12):5963-73, (2014). PMCID: PMC4066583.
Z. Chen, W. Holland, J.M. Shelton, A. Ali, X. Zhan, S. Won, W. Tomisato, C. Liu, X. Li, E.M. Moresco, B. Beutler. Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A 111(20):7367-72, (2014). PMCID:PMC4034201.
J.Q. Wang, Y.S. Jeelall, B. Beutler, K. Horikawa, C.C. Goodnow. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med 211(3):413-26, (2014). PMCID:PMC3949567.
S.R. Garrison, A.D. Weyer, M.E. Barabas, B.A. Beutler, K. Horikawa, C.C. Goodnow. A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain 155(5):896-905, (2014). PMCID:PMC3989381.
K. Tabeta, K. Hoebe, E.M. Janssen, Y. Xia, B. Beutler. Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice." Nat Immunol14(11):1102-3, (2013). PMID:24145779.
E.M. Moresco, X. Li, B. Beutler. Going forward with genetics: recent technological advances and forward genetics in mice. Am J Pathol 182:1462-73, (2013). PMID:23608223.
Y.T. Koh, J.C. Scatizzi, J.D. Gahan, B.R. Lawson, R. Baccala, K.M. Pollard, B.A. Beutler, A.N. Theofilopoulos, D.H. Kono. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol 190(10):4982-90, (2013). PMID: 23589617.
C.E. Teh, K. Horikawa, C.N. Arnold, B. Beutler, E.M. Kucharska, C.G. Vinuesa, E.M. Bertram, C.C. Goodnow, A. Enders. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation. Genes Immun 14(4):223-33, (2013). PMID:23552399.
K.R. Bull, A.J. Rimmer, O.M. Siggs, L.A. Miosge, C.M. Roots, A. Enders, E.M. Bertram, T.L. Crockford, B. Whittle, P.K. Potter, M.M. Simon, A.M. Mallon, S.D. Brown, B. Beutler, C.C. Goodnow, G. Lunter, R.J. Cornall. Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet 9:e1003219, (2013). PMCID: PMC3561070.
R. Baccala, R. Gonzalez-Quintial, A.L. Blasius, I. Rimann, K. Ozato, D.H. Kono, B. Beutler, A.N. Theofilopoulous. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci USA 110:2940-5, (2013). PMCID: PMC3581947.
O.M. Siggs, J. Cruite, X. Du, S. Rutschmann, E. Masliah, B. Beutler, M. Oldstone. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci USA 109(34):13733-8, (2012). PMID:22869751.
O.M. Siggs, N. Xiao, Y. Wang, H. Shi, W. Tomisato, X. Li, Y. Xia, B. Beutler. iRhom2 is required for the secretion of mouse TNF alpha. Blood May 1, (2012). PMID: 22550345.
S. Rutschmann, K. Crozat, X. Li, X. Du, J.C. Hanselman, A.A. Shigeoka, K. Brandl, D.L. Popkin, D.B. McKay, Y. Xia, E.M. Moresco, B. Beutler. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda) 2(4):499-504, (2012). PMCID: PMC3337478.
E. Narni-Mancinelli, B.N. Jaeger, C. Bernat, A. Fenis, S. Kung, A. De Gassart, S. Mahmood, M. Gut, S.C. Heath, J. Estellé, E. Bertosio, F. Vely, L.N. Gastinel, B. Beutler, B. Malissen, M. Malissen, I.G. Gut, E. Vivier, S. Ugolini. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335:344-8, (2012). PMID: 22267813.
K. Brandl, W. Tomisato, B. Beutler. Inflammatory bowel disease and ADAM17 deletion. N Engl J Med 366:190, (2012). PMID: 22236242.
O.M. Siggs, X. Li, Y. Xia, B. Beutler. ZBTB1 is a determinant of lymphoid development. J Exp Med 209:19-27, (2012). PMID: 22201126.
S. Won, C. Eidenschenk, C.N. Arnold, O.M. Siggs, L. Sun, K. Brandl, T.M. Mullen, G.R. Nemerow, E.M. Moresco, B. Beutler. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.J Virol 86:1802-8, (2012). PMID: 22114338.
P. Krebs, W. Fan, Y.H. Chen, K. Tobita, M.R. Downes, M.R. Wood, L. Sun, X. Li, Y. Xia, N. Ding, J.M. Spaeth, E.M. Moresco, T.G. Boyer, C.W. Lo, J. Yen, R.M. Evans, B. Beutler. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci USA 108:19678-82, (2011). PMID: 22106289.
E.M. Moresco and B. Beutler. Resisting viral infection: the gene by gene approach. Curr Opin Virol 1(6):513-8, (2011). PMID: 22440911.
A.L. Blasius, A.E. Dubin, M.J. Petrus, B.K. Lim, A. Narezkina, J.R. Criado, D.N. Wills, Y. Xia, E.M. Moresco, C. Ehlers, K.U. Knowlton, A. Patapoutian, B. Beutler. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci USA 108:19413-8, (2011). PMID: 22087007.
A.N. Theofilpoulos, D.H. Kono, B. Beutler, R. Baccala. Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res 31:867-86, (2011). PMID: 22029446.
L. Krieg, O. Milstein, P. Krebs, Y. Xia, B. Beutler, X. Du. Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice. Blood 118:6418-25, (2011). PMID: 21976678.
E.M. Moresco, D. LaVine, B. Beutler. Prion-like behavior of MAVS in RIG-I signaling. Cell Res 21:1643-5, (2011). PMID: 21931357.
E.M. Moresco, D. LaVine, Beutler B. Toll-like receptors. Curr. Biol. 21(13):R488-93, (2011).
C.H. Xia, E. Lu, H. Liu, X. Du, B. Beutler, X. Gong. The Role of VLDLR in Intraretinal Angiogenesis in Mice. IOVS 52(9):6572-9, (2011).
P. Krebs, K. Crozat, D. Popkin, M.B. Oldstone, B. Beutler. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood, 117:6582-8, (2011).
E.M. Moresco and B. Beutler. Special Delivery: Granulin Brings CpG DNA to Toll-like Receptor 9. Immunity 34:453-5, (2011).
C. Iavarone, K. Ramsauer, A.V. Kubarenko, J.C. Debasitis, I. Leykin, A.N. Weber, O.M. Siggs, B. Beutler, P. Zhang, G. Otten, U. D'Oro, N.M. Valiante, M.L. Mbow, A. Visintin. A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding. J Immunol.186(7):4213-22, (2011).
S. Beutler and B. Beutler. Ernest Beutler: his life and contribution to medical science. Br J Haematol.,152(5):543-50, (2011).
K. Crozat, C. Eidenschenk, B.N. Jaeger, P. Krebs, S. Guia, B. Beutler, E. Vivier, S. Ugolini. Impact of β2 integrin deficiency on mouse Natural Killer cell development and function. Blood, 117(10):2874-82, (2011).
B. Beutler and C.C. Goodnow. How host defense is encoded in the mammalian genome.Mamm Genome 22(1-2):1-5, (2011).
P.C. Ronald and B. Beutler. Plant and animal sensors of conserved microbial signatures. Science 330(6007):1061-4, Review, (2010).
G. Wingender, P. Krebs, B. Beutler, M. Kronenberg. Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency. J Immunol. 185(5):2721-9, (2010).
Z. Orinska, N. Föger, M. Huber, J. Marschall, F. Mirghomizadeh, X. Du, M. Scheller, P. Rosenstiel, T. Goldmann, A. Bollinger, B.A. Beutler, S. Bulfone-Paus. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood Journal, 116(15):2665-75, (2010).
A.L. Blasius and B. Beutler. Intracellular toll-like receptors. Immunity 32(3):305-15, (2010).
M.J. Barnes, H. Aksoylar, P. Krebs, T. Bourdeau, C.N. Arnold, Y. Xia, K. Khovananth, I. Engel, S. Sovath, K. Lampe, E. Laws, A. Saunders, G.W. Butcher, M. Kronenberg, K. Steinbrecher, D. Hildeman, H.L. Grimes, B. Beutler, K. Hoebe. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol. 184(7):3743-54, (2010).
A.N. Theofilopoulos, R. Gonzalez-Quintial, B.R. Lawson, Y.T. Koh, M.E. Stern, D.H. Kono, B. Beutler, R. Baccala. Sensors of the innate immune system: their link to rheumatic diseases. Nat Rev Rheumatol. 6(3):146-56, (2010).
R.A. Fock, S.L. Blatt, B. Beutler, J. Pereira, M. Tsujita, F.E. de Barros, P. Borelli. Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition. Nutrition. 26(10)1021-8, (2010).
N. Xiao, C. Eidenschenk, P. Krebs, K. Brandl, A.L. Blasius, Y. Xia, K. Khovananth, N.G. Smart, B. Beutler. The Tpl2 mutation sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 183(12):7975-83,(2009).
E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M.A. Lawson, M.B. Geuking, B. Beutler, T.F. Tedder, W.D. Hardt, P. Bercik, E.F. Verdu, K.D. McCoy, A.J. Macpherson. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325:617-620, (2009).
R. Baccala, R. Gonzalez-Quintial, B.R. Lawson, M.E. Stern, D.H. Kono, B. Beutler, A.N. Theofilopoulos. Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol. 5:448-56, (2009).
J. Truksa, T. Gelbart, H. Peng, E. Beutler, B. Beutler, P. Lee. Suppression of the hepcidin-encoding gene Hamp1 permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. British Journal of Haematology 147(4):571-81, (2009).
P. Borelli, F.E. Barros, K. Nakajima, S.L. Blatt, B. Beutler, J. Pereira, M. Tsujita, G.M. Favero, R.A. Fock. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. Braz J Med Biol Res. 42(6):523-30, (2009).
S.C. Pflugfelder, M.E. Stern; Symposium Participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf 7(2):67-77, Review, (2009).
J. Lichtnekert, V. Vielhauer, D. Zecher, O.P. Kulkarni, S. Clauss, S. Segerer, V. Hornung, T.N. Mayadas, B. Beutler, S. Akira, H.J. Anders. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol. 296(4):F867-74, (2009).
A.K. Kiemer, R.H. Senaratne, J. Hoppstadter, B. Diesel, L.W. Riley, K. Tabeta, S. Bauer, B. Beutler, B.L. Zuraw. Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria. Journal of Innate Immunity 1:29-45, (2009).
A.A. Brzezinska, J.L. Johnson, D.B. Munafo, K. Crozat, B. Beutler, W.B. Kiosses, B.A. Ellis, S.D. Catz. The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules. Traffic9(12): 2151-2164, (2008).
J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou, B. Beutler, L. Brossay, E. Vivier, T. Walzer. Cutting Edge: Priming of NK cells by IL-18. J Immunol. 181:1627-31, (2008).
B. Beutler, I.W. Milsark, A.C. Cerami. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. J Immunol. 181:7-9, (2008).
P. Georgel, X. Du, K. Hoebe, B. Beutler. ENU Mutagenesis in Mice. Methods Mol Biol. 415:1-16, (2008).
M.A. Freudenberg, S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler, C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology 213:193-203, (2008).
K. Hoebe and B. Beutler. Forward genetic analysis of TLR-signaling pathways: An evaluation. Adv Drug Deliv Rev. 60:824-9, (2008).
B. Beutler and E.M. Moresco. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol. 321:3-26, (2008).
B. Beutler. Immunology, phenotype first. Preface. Curr Top Microbiol Immunol.321:v-viii, (2008).
C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler, X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet. 17:1605-12, (2008).
B. Beutler and E.M. Moresco. Akirins vs. Infection. Nat Immunol. 9:7-9, (2008).
B. Beutler. The Toll-like Receptors. In:Genetic Susceptibility to Infection. R.L Kaslow, J. McNicholl and A.V.S. Hill, eds. Oxford University Press, pg. 165, (2008).
J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler, U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response. Human Immunol., 68:871-78, (2007).
B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler, B. Beutler. ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects. Nat. Genet.,39:1453-60, (2007).
B. Beutler. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunol Rev., 220:113-28, (2007).
B. Beutler, C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi, S. Akira. Genetic Analysis of Resistance to Viral Infection. Nat. Rev. Immunol., 7:753-766, (2007).
J. H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing, T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors. Immunity, 1:64-75, (2007).
P. Georgel, Z. Jiang, E. Kunz, J. Janssen, K. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, B. Beutler. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology, 362:304-313, (2007).
K. R. Taylor, K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler, R. L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44 and MD-2. J. Biol.Chem., 282:18265-75, (2007).
D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V.F.J. Quesniaux, B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling. Am. J. Pathol., 170:1640-1648, (2007).
K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J. Exp. Med., 204:853-863, (2007).
M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh, Y-M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7, and 9 is crucial for TLR signaling. J. Cell Biol., 177:265-275, (2007).
R. Baccala, K. Hoebe, D.H. Kono, B. Beutler, A. N. Theofilopoulos. Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity. Nat. Med., 13:543-551, (2007).
D.B. MunafÃ³, J.L. Johnson, B.A. Ellis, S. Rutschmann, B. Beutler, S.D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem. J., 402:229-39, (2007).
S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler, J. Han. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. Biotechniques, 42: 493-501, (2007).
B. Beutler, X. Du, Y. Xia. Precis on forward genetics in mice. Nat. Immunol., 8:659-664 (2007).
M. Otsuka, Q. Jing, P. Georgel, L. New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S.C. Das, A.K. Pattnaik, J. Carlos de la Torre, B. Beutler, J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27:123-124, (2007).
M. Huber, C. Kalis, S. Keck, Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler, C. Galanos, M.A. Freudenberg. R-form LPS, the master key to the activation of TLR4/MD2 positive cells. Eur. J. Immunol., 36:701-711, (2006).
B. Beutler, Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, K. Hoebe. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol., 24:353-389, (2006).
E. M. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler, K. Hoebe. Efficient T cell activation via a toll-interleukin 1 receptor-independent pathway. Immunity, 24:787-799, (2006).
K. Tabeta, K. Hoebe, E.M Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein, B. Beutler. The Unc93b1 mutation 3d disrupts exogenous antigen presentation signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol. 7:156-164, (2006).
S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B.I. Dahiyat, P. Steed, B. Beutler. PanR1, a dominant negative missense allele of Tumor Necrosis Factor a , does not impair lymphoid development. J. Immunol., 176:7525-7532, (2006).
K. Crozat, P. Georgel, S. Rutschmann, N. Mann, X. Du, K. Hoebe, B. Beutler. Analysis of the MCMV resistome by ENU mutagenesis. Mamm. Genome, 17:398-406, (2006).
Z. Jiang, P. Georgel, C. Li, J. Choe, K. Crozat, S. Rutschmann, X. Du, T. Bigby, S. Mudd, S. Sovath, I.A. Wilson, A. Olson, B. Beutler. Details of Toll-like receptor: adapter interaction revealed by germline mutagenesis. Proc. Natl. Acad. Sci. U.S.A., 103:10961-10966, (2006).
D. Nemazee, A.L. Gavin, K. Hoebe, B. Beutler. Commentary: The TLR independence of antibody responses. Nature, 441: E4, (2006).
K. Hoebe, Z. Jiang, K. Tabeta, X. Du, P. Georgel, K. Crozat, B. Beutler. Genetic analysis of innate immunity. Adv. in Immunol., 91:175-226, (2006).
K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, B. Beutler.TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr. Pharm. Des, 12: 4123-4134, (2006).
H. Fischer, M. Yamamoto, S. Akira, B. Beutler, C. Svanborg. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur. J. Immunol., 36:267-277, (2006).
C.H. Xia, H. Liu, D. Cheung, C. Cheng, E. Wang, X. Du, B. Beutler. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development, 133: 2033-2040, (2006).
K. Hoebe and B. Beutler. TRAF3: a new component of the TLR-signaling apparatus. Trends Mol. Med., 12:187-189, (2006).
L. Gitlin, W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R.A. Flavell, M.S. Diamond, M. Colonna. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. U.S.A., 103:8459-8464, (2006).
Y. Kinjo, E. Tupin, D.Wu, M. Fujio, R. Garcia-Navarro, M.R-E-I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I.A. Wilson, M. Tsuji, T.J. Sellati, C-H. Wong, M. Kronenberg. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol., 7:978-986, (2006).
A. Casrouge, S-Y Zhang, C. Eidenschenk, E. Jouanguy, A. Puel, K. Yang, A. Alcais, C. Picard, N. Mahfoufi, N. Nicolas, L. Lorenzo, S. Plancoulaine, B. Senechal, F. Geissmann, K. Tabeta, K. Hoebe, X. Du, R. L. Miller, B. Heron, C. Mignot, T. B. de Villemeur, P. Lebon, O. Dulac, F. Rozenberg, B. Beutler, M. Tardieu, L. Abel, J-L. Casanova. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314:308-12, (2006).
D. Togbe, G. Aurore, N. Noulin, V.F. Quesnizux, S. Schnyder-Candrian, B. Schnyder , V. Vasseur, S. Akira, K. Hoebe, B. Beutler, B. Ryffel, I. Couillin. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. LabInvest., 86:1126-1135, (2006).
T.P. Meehan, K. Tabeta, X. Du, L.S. Woodward, K. Firozi, B. Beutler, M.J. Justice. Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm. Genome, 17:1162-1171, (2006).
A.L. Gavin, B. Duong, T. Ota, K. Hoebe, B. Beutler, D. Nemazee. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science, 314:1936-1938, (2006).
B. Beutler. Fighting malaria: mosquitoes know how. Immunity, 25:530-531, (2006).
C.H. Xia, H. Liu, M. Wang, D. Heung, A. Park, Y. Yang, X. Du, B. Chang, B. Beutler, X. Gong. Characterization of mouse mutants with abnormal RPE cells. Adv. Exp. Med. Biol., 572:95-100, (2006).
A.N. Theofilopoulos, R. Baccala, B. Beutler, D.H. Kono. Type I interferons (a/ÃŸ) in immunity and autoimmunity. Annu. Rev. of Immunol., 23:307-335, (2005).
B. Beutler, K. Hoebe, P. Georgel, X. Du. Forward genetic analysis of TLR pathways: A shared system for the detection of endotoxin and viral infection. Editor: T. Rich. In: Toll and Toll-like receptors: an immunologic perspective,Kluwer Academic/Plenum publishers, New York, NY, pages 168-177, (2005).
K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zahringer, B. Beutler. CD36 is a sensor of diacylglycerides. Nature, 433:523-527, (2005).
T.R. Hawn, A. Verbon, M. Janer, L.P. Zhao, B. Beutler, A. Aderem. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires disease. Proc. Natl. Acad. Sci. U.S.A., 102:2487-2489, (2005).
B. Beutler, K. Crozat, J.A. Koziol, P. Georgel. Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model. Curr. Opin. Immunol., 17:36-43, (2005).
J. Mattner, K.L. DeBord, N. Ismail, R.D. Goff, C. Cantu III, D. Zhou, P. Sait-Mezard, V. Wang, Y. Gao, N. Yin, K. Hoebe, O. Schneewind, D. Walker, B. Beutler, L. Teyton, P.B. Savage, A. Bendelac. Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525-529, (2005).
P. Georgel, K. Crozat, X. Lauth, S. Sovath, K. Hoebe, X. Du, S. Rutschmann, Z. Jiang, T. Bigby, V. Nizet, B. Beutler. A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial infections. Infect. Immun., 73:4512-4521, (2005).
Z. Zhou, K. Hoebe, X. Du, Z. Jiang, L. Shamel, B. Beutler. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 upregulation. Eur. J. Immunol., 35:1918-1927, (2005).
Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol.,6:565-570, (2005).
K. Hoebe and B. Beutler. Unraveling innate immunity using large scale ENU mutagenesis. Tissue Antigens, 65:395-401, (2005).
B. Beutler and J-L. Casanova. New frontiers in immunology: Workshop on the Road Ahead: Future directions in fundamental and clinical immunology. EMBO Rep., 6:620-623, (2005).
B. Beutler, K. Hoebe, P. Georgel, K. Tabeta, X. Du. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. Adv. Exp. Med. Biol., 560:29-39 (2005).
K.I. Kim, O. Malakhova, K. Hoebe, M. Yan, B. Beutler, D-E. Zhang. Enhanced anti-bacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type I IFN-signaling. J. Immunol., 175:847-854, (2005).
B. Beutler. The Toll-like receptors: Analysis by forward genetic methods. Immunogenetics, 57:385-392, (2005).
C.W. Wieland, S. Florquin, N.A. Maris, K. Hoebe, B. Beutler, K. Takeda, S. Akira, T. van der Poll. The MyD88 dependent but not the MyD88 independent pathway of Toll-like receptor 4 signaling is important in clearing non-typeable Haemophilus influenzae from the mouse lung. J. Immunol.,175:6042-6049, (2005).
X. Du, K. Tabeta, K. Hoebe, N. Mann, K. Crozat, S. Mudd, B. Beutler. An essential role for Rxr a in Th2 development. Eur. J. Immunol, 35:3414-3423, (2005).
B. Beutler. Innate Immunity. In: Williams Hematology, 7th Edition. Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J.T., eds. McGraw-Hill Medical Press, New York, NY, pp. 231-238, (2005).
B. Beutler, P. Georgel, B. Croker, K. Crozat. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief. Funct. Genomic Proteomic, 4:203-213, (2005).
H.Q. Liu, X. Du, M. Wang, Q.L. Huang, L.L. Ding, H.W. McDonald, J.R. Yates, B. Beutler, J. Horwitz, X.H. Gong. Crystallin gamma B-14F mutant protein binds to alpha-crystallin and affects lens transparency. J.Biol.Chem.280:25071-25078, (2005).
B. Beutler. Microbial Pathogenesis and the discovery of Toll-like receptor function. In: Vaccine Adjuvants: Immunological and Clinical Principles. Hackett, C., and Harn, D.A., eds. Humana Press, Totowa, NJ, pg. 1-24, (2005).
X. Du, K. Tabeta, K. Hoebe, H. Liu, N. Mann, S. Mudd, K. Crozat, S. Sovath, X. Gong, B. Beutler. Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics, 166:331-340, (2004).
K. Tabeta, P. Georgel, E.M. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, L. Alexopoulou, R. Flavell, B. Beutler. TLR9 and TLR3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A., 101:3516-3521, (2004).
N. Anfossi, S.H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C.B. DiCioccio, E. Tomasello, B. Beutler, S.L. Reiner, L. Alexopoulou, O. Lantz , D.H. Raulet, L. Brossay, E. Vivier. Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules. J. Immunol., 173:3773-3782, (2004).
K. Crozat and B. Beutler. TLR7: A new sensor of viral infection. Proc. Natl. Acad. Sci. U.S.A., 101:6835-6836, (2004).
B. Beutler. Preview: SHIP, TGF-ÃŸ, and Endotoxin Tolerance. Immunity, 21:134-135, (2004).
K. Hoebe, E.M. Janssen, B. Beutler. The Interface between Innate and Adaptive Immunity. Nat. Immunol., 5:971-974, (2004).
B. Beutler. The Toll-like receptors and their place in immunology: Where does the immune response to infection begin? Nat. Rev. Immunol., 4:498 (2004).
B. Beutler. Inferences, questions and possibilities in Toll-like receptor signaling. Nature, 430:257-263, (2004).
K. Hoebe and B. Beutler. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J. Endotoxin Res., 10:130-136, (2004).
I. Smythe, X. Du, M.S. Taylor, M. Justice, B. Beutler, I.J. Jackson. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc. Natl. Acad. Sci. U.S.A., 101:13560-13565, (2004).
H. Weighardt, G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler, B. Holzmann. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur. J. Immunol., 34:558-564, (2004).
B. Beutler. Innate Immunity: an overview. Mol. Immunol., 40:845-859, (2004).
B. Beutler, K. Hoebe, L. Shamel. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C. R. Biol., 327:571-80, (2004).
B. Beutler and J. Hoffmann. Innate immunity: Editorial overview. Curr. Opin. Immunol., 16:1-3, (2004).
B. Beutler, K. Hoebe, P. Georgel, K. Tabeta, X. Du. Genetic analysis of innate immunity: TLR adapter proteins in innate and adaptive immune responses. Microbes Infection, 6:1374-1381, (2004).
E.T. Rietschel, M. Rietschel, B. Beutler. How the mighty have fallen: fatal infectious diseases of divine composers. Editors: B.A. Cunha and R.C. Moellering. In: Infectious Diseases Clinics of North America, W.B. Saunders Company, Philadelphia, PA, 18:311-339, (2004).
B. Beutler. Toll-like Receptors: The Origins of Inflammation. In: The Cytokine Handbook 4th Edition. T.A. Thomson and M.T. Lotze eds., Academic Press, 809-822, (2003).
B. Beutler and S. Beutler. The pathogenesis of fever. In: Cecil Textbook of Medicine 22nd Edition. D. Ausiello eds., W.B. Saunders, Philadelphia, PA, (2003).
K. Hoebe, X. Du, J. Goode, N. Mann, B. Beutler. Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J.Endotox.Res., 9:250-255, (2003).
I. Smirnova, N. Mann, A. Dols, H.H. Derkx, M. Hibberd, M. Levin, B. Beutler. Assay of locus-specific genetic load implicates rare TLR4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. U.S.A., 100:6075-6080, (2003).
K. Hoebe, X. Du, P. Georgel, E.M. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han, B. Beutler.Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 424:743-748, (2003).
K. Hoebe, E.M. Janssen, S.O. Kim, L. Alexopoulou, R.A. Flavell, J. Han, B. Beutler. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol., 4:1223-1229, (2003).
T.R. Hawn, A. Verbon, K.D. Lettinga, L.P. Zhao, S.S. Li, R.J. Laws, S.J. Skerrett, B. Beutler, L. Schroeder, A. Nachman, A. Ozinsky, K.D. Smith, A. Aderem. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J. Exp. Med., 198:1563-1572, (2003).
B. Beutler. Innate immune responses to microbial poisons: Discovery and function of the Toll-like receptors. Annu. Rev. Pharmacol. Toxicol., 43:609-628, (2003).
B. Beutler. Key inflammatory and stress pathways in critical illness the central role of the Toll-like receptors. Crit. Care, 7:39-46, (2003).
B. Beutler and E.T. Rietschel. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol., 3:169-176, (2003).
B.J. Stevenson, C. Iseli, B. Beutler, C.V. Jongeneel. Using transcriptome data to unravel the fine structure of genes involved in sepsis. J. Infect. Dis., 187:S308-S314, (2003).
B. Beutler. TNF In: Encyclopedia of Hormones & Related Cell Regulators. H.L. Henry and A.W. Norman eds., Academic Press, San Diego, CA. 536-539, (2003).
B. Beutler, X. Du, K. Hoebe. From phenomenon to phenotype, and from phenotype to gene: forward genetics and the problems of sepsis. J. Infect. Dis., 187:S321-326, (2003).
B. Beutler, K. Hoebe, X. Du, R.J. Ulevitch. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol., 74:479-485, (2003).
B. Beutler, K. Hoebe, X. Du, E.M. Janssen, P. Georgel, K. Tabeta. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses. Scan.J. Infect.Dis., 35:563-567, (2003).
B. Beutler. Not "molecular patterns" but molecules. Immunity, 19:155-156 (2003).
S.O. Kim, Q. Jing, K. Hoebe, B. Beutler, N.S. Duesbery, J. Han. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-a. J. Biol. Chem., 278:7413-7421, (2003).
B. Beutler. Toll-like receptors: how they work and what they do. Curr. Opin. Hematol. 9:2-10, (2002).
B. Beutler. Endotoxin antagonism: conceptual basis and therapeutic potential. Expert Opin. Ther. Targets, 6:147-158, (2002).
B. Beutler. TLR4 as the mammalian endotoxin sensor. In: Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 109-120, (2002).
B. Beutler and M. Rehli. Evolution of the TIR, Tolls and TLRs: functional inferences from computational Biology. Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 1-21, (2002).
B. Beutler. LPS in microbial pathogenesis: promise and fulfillment. J. Endotox. Res., 8:329-335, (2002).
B. Beutler and E. Beutler. Toll-like receptor 4 polymorphisms and atherogenesis. New Engl. J. Med., 347:1978-1979, (2002).
I. Smirnova, M. Hamblin, C. McBride, B. Beutler, A. di Rienzo. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics, 158:1657-1664, (2001).
B. Beutler. Innate Immune Sensing and the Toll-like Receptors. In: The Liver: Biology and Pathobiology. I.M. Arias, J.L. Boyer, F.V. Chisari, et al., eds., 4th Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 581-589, (2001).
B. Beutler and A. Poltorak. Toll we meet again. Nat. Immunol., 2:9-10, (2001).
B. Beutler and A. Poltorak. The sole gateway to endotoxin response: how Lps was identified as Tlr4, and its role in innate immunity. Drug Metab. Dispos., 29:474-78, (2001).
B. Beutler and A. Poltorak. The Search for Lps: 1993-1998. J. Endotox. Res. 6:269-293, (2001).
B. Beutler. The Toll-like receptors as the primary sensors of the innate immune system. The Immunologist 8:123-130, (2001).
D. Kimbrell and B. Beutler. Evolution and genetics of innate immunity. Nat. Rev., 2:256-267, (2001).
B. Beutler, X. Du, A. Poltorak. Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J. Endotox. Res., 7:277-280, (2001).
B. Beutler and A. Poltorak. Sepsis and the evolution of the innate immune response. Crit. Care Med., 29:S2-7, (2001).
B. Beutler. Autoimmunity and apoptosis: The Crohn's connection. Immunity,15:5-14, (2001).
H.R. Redl, A. Aderem, B. Beutler, T. Calandra, J.P. Mira, R. Ulevitch. Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components. Crit. Care Med., 29:S19-20, (2001).
R. Ulevitch and B. Beutler. Genetic analysis of host responses in sepsis. Curr. Infect. Dis. Rep., 3:419-426, (2001).
B. Beutler. Sepsis begins at the interface of pathogen and host. Biochem. Soc. Trans., 29:853-859, (2001).
A. Poltorak, P. Ricciardi-Castagnoli, S. Citterio, B. Beutler. Physical contact between LPS and TLR4 revealed by genetic complementation. Proc. Natl. Acad. Sci. U.S.A., 97:2163-2167, (2000).
I. Smirnova, A. Poltorak, E.K.L. Chen, C. McBride, B. Beutler. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol., 1:1-10, (2000).
J. Nattermann, X. Du, Y. Wei, D. Shevchenko, B. Beutler. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4. J. Endotox. Res.,6:257-264, (2000).
A. Poltorak, I. Smirnova, R. Clisch, B. Beutler. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J.Endotox.Res., 6:51-56, (2000).
X. Du, A. Poltorak, Y. Wei, B. Beutler. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw.,11:362-371, (2000).
M. Rehli, A. Poltorak, L. Schwarzfischer, S.W. Krause, R. Andreesen, B. Beutler. PU.1 and interferon consensus sequence-blinding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J. Biol. Chem., 275:9773-9781, (2000).
B. Beutler. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity. Curr. Opin. Microbiol., 3:23-28, (2000).
B. Beutler. TLR4: Central component of the sole mammalian LPS sensor. Curr. Opin. Immunol., 12:20-26, (2000).
B. Beutler and A. Poltorak. Positional cloning of Lps and the general role of toll-like receptors in the innate immune response. Eur. Cytokine Netw.,11:143-152, (2000).
J.A. Koziol and B. Beutler. Estimation of physical distance in the genome through probabilistic analysis of marker density and yeast artificial chromosome (YAC) size. Biom. J., 41: 251-257, (1999).
G.R. Brown, G. Lindberg, J. Meedings, M. Silva, B. Beutler, D.Thiele.Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology, 116:593-601, (1999).
X. Du, A. Poltorak, M. Silva, B. Beutler. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells Mol. Dis., 25:328-338, (1999).
A. Poltorak, I. Smirmova, X. He, M.-Y. Liu, C. Van Huffel, O. McNally, D. Birwell, E. Alejos, M. Silva, X. Du, P. Thompson, E.K.L. Chan, J. Ledesma, B. Roe, S. Clifton, S. Vogel, B. Beutler. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis., 24:340-355, (1998).
A. Poltorak, X. He, I. Smirnova, M.-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, B. Beutler. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the TLR4 gene. Science, 282:2085-2088, (1998).
B. Beutler and F. Bazzoni. TNF, apoptosis and autoimmunity: a common thread? Blood Cells Mol. Dis., 24:216-230, (1998).
G.R. Brown, M.D. Silva, P.A. Thompson, B. Beutler. Lymphoid hyperplasia, CD45RB high/low T cell imbalance, and suppression of type I diabetes mellitus result from TNF blockade in NOD 6 NOD-scid adoptive T cell transfer. Diabetologia, 41:1502-1510, (1998).

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