Source: https://www.medizin.uni-muenster.de/zmbe/die-institute-des-zmbe/inst-fuer-molekulare-virologie/institutassoziierte-forschergruppe-pd-dr-ehrhardt/forschergruppe-pd-dr-ehrhardt-publikationen/
Timestamp: 2019-04-19 20:32:25+00:00

Document:
Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C.
Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability.
Derksen A, Kühn J, Hafezi W, Sendker J, Ehrhardt C, Ludwig S, Hensel A.
Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus.
KathumOA. Schräder T, Anhlan D, NordhoffC, LiedmannS, Pande A, MellmannA, EhrhardtC, WixlerV, LudwigS.
Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.
Niezold T, Storcksdieck Genannt Bonsmann M, Maaske A, Temchura V, Heinecke V, Hannaman D, Buer J, Ehrhardt C, Hansen W, Überla K, Tenbusch M.
DNA vaccines encoding DEC205-targeted antigens: Immunity or Tolerance?
Torres-Gómez H, Lehmkuhl K, Frehland B, Daniliuc C, Schepmann D, Ehrhardt C, Wünsch B.
Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, Ehrhardt C.
Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization.
Cell Microbiol. 2015 Mar;17(3):303-17. doi: 10.1111/cmi.12375. Epub 2014 Nov 19.
Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C.
Nat Commun. 2014 Dec 9;5:5645. doi: 10.1038/ncomms6645.
Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Ehrhardt C, Ludwig S, Hains DS, Webby R, McCullers JA.
NS1 mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections; insights into 1918 H1N1 pandemic?
Nacken W, Anhlan D, Hrincius ER, Mostafa A, Wolff T, Sadewasser A, Pleschka S, Ehrhardt C, Ludwig S.
Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.
Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C.
New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant.
J Infect Dis 209: 532-541.
Hrincius ER, Liedmann S, Anhlan D, Wolff T, Ludwig S, Ehrhardt C.
Avian influenza viruses inhibit the major cellular signalling integrator c-Abl.
Haasbach E, Hartmayer C, Hettler A, Sarnecka A, Wulle U, Ehrhardt C, Ludwig S, Planz O.
Antiviral activity of Ladania067, an extract from wild black currant leaves against influenza A virus in vitro and in vivo.
Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C.
The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.
Derksen A, Hensel A, Hafezi W, Herrmann F, Schmidt TJ, Ehrhardt C, Ludwig S, Kuhn J.
3-O-Galloylated Procyanidins from Rumex acetosa L. Inhibit the Attachment of Influenza A Virus.
Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U.
Annexin A6-balanced late endosomal cholesterol controls influenza A replication and propagation.
Stab V, Nitsche S, Niezold T, Storcksdieck Genannt Bonsmann M, Wiechers A, Tippler B, Hannaman D, Ehrhardt C, Überla K, Grunwald T, Tenbusch M.
Protective efficacy and immunogenicity of a combinatory DNA vaccine against Influenza A Virus and the Respiratory Syncytial Virus.
The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus.
Feld M, Shpacovitch V, Ehrhardt C, Fastrich M, Goerge T, Ludwig S, Steinhoff M.
Proteinase-activated receptor-2 agonist activates anti-influenza mechanisms and modulates IFNgamma-induced antiviral pathways in human neutrophils.
Biomed Res Int 2013: 879080.
Ehrhardt C, Dudek SE, Holzberg M, Urban S, Hrincius ER, Haasbach E, Seyer R, Lapuse J, Planz O, Ludwig S.
A plant extract of Ribes nigrum folium possesses anti-influenza virus activity in vitro and in vivo by preventing virus entry to host cells.
Ehrhardt C*, Rückle A*, Hrincius ER, Haasbach E, Anhlan D, Ahmann K, Banning C, Reiling SJ, Kühn J, Strobl S, Vitt D, Leban J, Planz O, Ludwig S.
The NF-kappaB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance.
Winkler M, Bertram S, Gnirß K, Nehlmeier I, Gawanbacht A, Kirchhoff F, Ehrhardt C, Ludwig S, Kiene M, Moldenhauer AS, Goedecke U, Karsten CB, Kühl A, Pöhlmann S.
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.
Niemann S, Ehrhardt C, Medina E, Warnking K, Tuchscherr L, Heitmann V, Ludwig S, Peters G, Löffler B.
Combined action of influenza virus and Staphylococcus aureus panton-valentine leukocidin provokes severe lung epithelium damage.
J Infect Dis 206: 1138-1148.
Hrincius ER, Hennecke AK, Gensler L, Nordhoff C, Anhlan D, Vogel P, McCullers JA, Ludwig S, Ehrhardt C.
A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice.
Am J Pathol 180: 2361-2374.
Meisen I, Dzudzek T, Ehrhardt C, Ludwig S, Mormann M, Rosenbruck R, Lumen R, Kniep B, Karch H, Muthing J.
The human H3N2 influenza viruses A/Victoria/3/75 and A/Hiroshima/52/2005 preferentially bind to alpha2-3-sialylated monosialogangliosides with fucosylated poly-N-acetyllactosaminyl chains.
Nacken W, Ehrhardt C, Ludwig S.
Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses.
Nordhoff C, Hillesheim A, Walter BM, Haasbach E, Planz O, Ehrhardt C, Ludwig S, Wixler V.
The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection.
Rückle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S.
The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-kappaB pathway and p52/RelB-dependent gene expression in lung epithelial cells.
Seyer R, Hrincius ER, Ritzel D, Abt M, Mellmann A, Marjuki H, Kuhn J, Wolff T, Ludwig S, Ehrhardt C.
Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice.
J Infect Dis 205: 262-271.
From virus entry to release: the diverse functions of PI3K during RNA virus infection.
Hrincius ER, Dierkes R, Anhlan D, Wixler V, Ludwig S, Ehrhardt C.
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Eierhoff T, Hrincius ER, Rescher U, Ludwig S, Ehrhardt C.
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
Hrincius, E. R., V. Wixler, T. Wolff, R. Wagner, S. Ludwig, and C. Ehrhardt.
CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK mediated apoptotic responses.
Ma, W., D. Brenner, Z. Wang, B. Dauber, C. Ehrhardt, K. Hogner, S. Herold, S. Ludwig, T. Wolff, K. Yu, J. A. Richt, O. Planz, and S. Pleschka.
The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV.
Ehrhardt, C., R. Seyer, E. R. Hrincius, T. Eierhoff, T. Wolff, and S. Ludwig.
Pauli, E. K., M. Schmolke, H. Hofmann, C. Ehrhardt, E. Flory, C. Munk, and S. Ludwig.
High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity.
Eierhoff, T., S. Ludwig, and C. Ehrhardt.
The influenza A virus matrix protein as a marker to monitor initial virus internalisation.
Entschladen, F., J. A. Lindquist, E. Serfling, G. Thiel, A. Kieser, K. Giehl, C. Ehrhardt, S. M. Feller, O. Ullrich, F. Schaper, O. Janssen, R. Hass, and K. Friedrich.
Signal transduction-receptors, mediators, and genes.
Ehrhardt, C., and S. Ludwig.
Friedrich, K., J. A. Lindquist, F. Entschladen, E. Serfling, G. Thiel, A. Kieser, K. Giehl, C.Ehrhardt, S. M. Feller, O. Ullrich, F. Schaper, O. Janssen, and R. Hass.
Signal transduction in the footsteps of goethe and schiller.
Feld, M., V. M. Shpacovitch, C. Ehrhardt, C. Kerkhoff, M. D. Hollenberg, N. Vergnolle, S.Ludwig, and M. Steinhoff.
Agonists of proteinase-activated receptor-2 enhance IFN gamma-inducible effects on human monocytes: role in influenza A infection.
Vogl, T., K. Tenbrock, S. Ludwig, N. Leukert, C. Ehrhardt, M. A. van Zoelen, W. Nacken, D.Foell, T. van der Poll, C. Sorg, and J. Roth.
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
Ehrhardt, C., T. Wolff, and S. Ludwig.
Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
Droebner, K., C. Ehrhardt, A. Poetter, S. Ludwig, and O. Planz.
CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice.
Ehrhardt, C., E. R. Hrincius, V. Korte, I. Mazur, K. Droebner, A. Poetter, S. Dreschers, M. Schmolke, O. Planz, and S. Ludwig.
Mazur, I., W. J. Wurzer, C. Ehrhardt, S. Pleschka, P. Puthavathana, T. Silberzahn, T. Wolff, O. Planz, and S. Ludwig.
Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB inhibiting activity.
Ehrhardt, C., T. Wolff, S. Pleschka, O. Planz, W. Beermann, J. G. Bode, M. Schmolke, and S. Ludwig.
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
Ehrhardt, C., M. Schmolke, A. Matzke, A. Knoblauch, C. Will, V. Wixler and S. Ludwig.
Polyethylenemine, a cost-effective transfection reagent.
Ehrhardt, C., H. Marjuki, T. Wolff, B. Nuernberg, O. Planz, S. Pleschka and S. Ludwig.
Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence.
Marjuki, H., M. I. Alam, C. Ehrhardt, R. Wagner, O. Planz, H. D. Klenk, S. Ludwig, and S. Pleschka.
Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling.
Unterstab, G., S. Ludwig, A. Anton, O. Planz, B. Dauber, D. Krappmann, G. Heins, C. Ehrhardt, and T. Wolff.
Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Bourteele, S., K. Oesterle, S. Pleschka, G. Unterstab, C. Ehrhardt, T. Wolff, S. Ludwig, and O. Planz.
Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication.
Ehrhardt, C., C. Kardinal, W. J. Wurzer, T. Wolff, C. von Eichel-Streiber, S. Pleschka, O. Planz, and S. Ludwig.
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.
Wurzer, W. J., C. Ehrhardt, S. Pleschka, F. Berberich-Siebelt, T. Wolff, H. Walczak, O. Planz, and S. Ludwig.
NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation.
Ludwig, S., T. Wolff, C. Ehrhardt, W. J. Wurzer, J. Reinhardt, O. Planz, and S. Pleschka.
MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.
Planz, O., S. Pleschka, K. Oesterle, F. Berberich-Siebelt, C. Ehrhardt, L. Stitz, and S. Ludwig.
Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex.
Wurzer, W. J., O. Planz, C. Ehrhardt, M. Giner, T. Silberzahn, S. Pleschka, and S. Ludwig.
Caspase 3 activation is essential for efficient influenza virus propagation.
Bode, J. G., S. Ludwig, C. Ehrhardt, U. Albrecht, A. Erhardt, F. Schaper, P. C. Heinrich, and D. Haussinger.
IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.
Ludwig, S.*, X. Wang*, C. Ehrhardt*, H. Zheng, N. Donelan, O. Planz, S. Pleschka, A. Garcia-Sastre, G. Heins, and T. Wolff.
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.
Scheller, C., S. Sopper, C. Ehrhardt, E. Flory, P. Chen, E. Koutsilieri, S. Ludwig, V. ter Meulen, and C. Jassoy.
Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes.
Pleschka, S., T. Wolff, C. Ehrhardt, G. Hobom, O. Planz, U.R. Rapp, S. Ludwig.
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signaling cascade.
Ludwig, S.*, C. Ehrhardt*, E. R. Neumeier, M. Kracht, U. R. Rapp, and S. Pleschka.
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway.

References: V.

 V. 
 V. 
 V. 
 V. 
 V.