Source: http://fhp.bsu.by/research-laboratories?id=76:laboratoriya-biokhimii-lekarstvennykh-preparatov&catid=54
Timestamp: 2019-04-21 04:44:04+00:00

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The laboratory was established in 1996. The Head of the laboratory is V. Shkumatov, D.Sc, Professor, Correspondent member of the NAS of Belarus.
combined ultrasonic-enzymatic thrombolysis, use of enzymes in replacement therapy.
molecular mechanisms of pulsed low- frequency ultrasonic effect on the precursor molecules and active forms of several enzymes have been discovered in the development of a new ultrasonic-enzymatic treatment of thromboembolic conditions.
technology for proddction new medicinal form of the cardiac drug on the basis of phosphocreatine, kits of reagents for enzyme-linked immunosorbent assay for determination of troponins and markers ofpathology of immune and allergic disorders developed in collaboration with JV Co.Ltd «Farmlend».
Revealing of novel affine interactions of NBD-labeled fluorescent steroids with bacterial steroid–converting oxidoreductases using molecular docking/ Ya.V. Faletrov, E.V. Rudaya, H.V. Hlushko, I.P. Edimecheva, V.M. Shkumatov // 50th FEBS EMBO 2014 Conference «From molecular mechanisms to Cellular Functions», 30 Aug - 4 Sep 2014, Paris, France / FEBS J. – 2014. – Vol. 281(Suppl. 1). – P. 638.
Faletrov YV, Bialevich KI, Edimecheva IP, Kostsin DG, Rudaya EV, Slobozhanina EI, Shkumatov VM. 22-NBD-cholesterol as a novel fluorescent substrate for cholesterol-converting oxidoreductases //J. Steroid Biochem Mol Biol. – 2013. - Vol.134. – P. 59-66.
Cherniavsky E.A., Strakha I.S., Adzerikho I.E., Shkumatov V.M. Ultrasound-assisted fibrinogen and fibrin proteolysis// Advances in Medicine and Biology, Vol.40 // Ed. L.V. Berhardt. – Nova Science Publishers, 2013. - P.281-296. (ISBN: 978-1-62100-421-9).
Mauersberger S., Novikova L.A., Shkumatov V.M. Cytochrome P450 expression in Yarrowia lipolytica and its use in steroid biotransformation // Yarrowia lipolytica, Microbiology Monographs 25 // Ed. G. Barth. – Springer-Verlag Berlin Heidelberg, 2013. – P. 171-226.
Ya.V. Faletrov, N.S. Frolova, E.V. Rudaya, D.G. Kostin, E.I. Slobozhanina, and V.M. Shkumatov 22-NBD-cholesterol, a new fluorescent substrate ofbacterial cholesterol-oxidases // Chem. Nat. Comp. – 2012. - Vol. 48, №. 1. – P. 172-173.
Cherniavsky E.A., Strakha I.S., Adzerikho I.E., Shkumatov V.M. Ultrasound-assisted fibrinogen and fibrin proteolysis// Advances in Medicine and Biology, Vol.40 // Ed. L.V. Berhardt. – Nova Science Publishers, 2012. (ISBN: 978-1-62100-421-9).
Cherniavsky E.A., Strakha I.S., Adzerikho I.E., Shkumatov V.M. Ultrasound-assisted fibrinogen and fibrin proteolysis// Advances in Medicine and Biology, Vol.40 // Ed. L.V. Berhardt. – Nova Science Publishers. - 2012. - P. 281-296.
Cherniavsky E.A., Strakha I.S., Adzerikho I.E., Shkumatov V.M. Effects of low frequency ultrasound on some properties of fibrinogen and its plasminolysis // BMC Biochemistry – 2011 – 12:60.
N.V. Loginova, T.V. Koval’chuk, Y.V. Faletrov, Y.S. Halauko, N.P. Osipovich, G.I. Polozov, R.A. Zheldakova, A.T. Gres, A.S. Halauko, I.I. Azarko, V.M. Shkumatov, O.I. Shadyro / Redox-active metal(II) complexes of sterically hindered phenolic ligands: Antibacterial activity and reduction of cytochrome c. Part II. Metal(II) complexes of o-diphenol derivatives of thioglycolic acid // Polyhedron. – 2011. – V. 30. – P. 2581–2591.
Cherniavsky, E.A. The extraction effect of ultrasound during plasma clot disruption / Cherniavsky E.A., Adzerikho I.E., Shkumatov V.M. // Biochemistry (Moscow). Suppl. B: Biomed. Chem. – 2009. – Vol.3, № 2. – P. 164-171.
Loginova N.V., Faletrov Y.V., Koval’chuk T.V., Osipovich N.P., Polozov G.I., Chernyavskaja A.A., Zheldakova R.A., Azarko I.I., Gres’ A.T., Shadyro O.I., Shkumatov V.M. / Redox-active metal (II) complexes of sterically hindered phenolic ligands: antibacterial activity and reduction of cytochrome c. // Polyhedron– 2010. – V.29. - P. 1646-1652.
Shkumatov V.M., Usova E.V., Frolova N.S., Barth G., Mauersberger S. / Effect of steroid biosynthesis modifiers on progesterone biotransformation by recombinant yeast expressing cytochrome P450c17// Biochem. (Moscow) Suppl. Series B: Biomed. Chem. – 2007. - V.1. P. 87-94.
Shkumatov V.M., Radyuk V.G., Faletrov Y.V., Vinogradova A.A., Luzikov V.N., Novikova L.A. / Expression of cytochrome P450scc in Escherichia coli cells: intracellular localization and interaction with bacterial redox proteins // Biochemistry (Mosc.) - 2006. – V.71. - P. 884-892.
V. M. Shkumatov, N. S. Frolova, E. V. Rudaya, Ya. V. Faletrov, S. Mauersberger, G. Barth / Range of substrates and steroid bioconversion reactions performed by recombinant microorganisms Saccharomyces cerevisiae and Yarrowia lipolytica expressing cytochrome P450c17// Applied Biochemistry and Microbiology – 2006. – Vol. 42 – P. 472-478 .
S.L.Ovsianko, E.A.Chernyavsky, V.T.Minchenya, I.E.Adzerikho, V.M. Shkumatov / Effect of ultrasound on activation of serine protease precursors// Ultrasonics Sonochem. – 2005. – V.12. - P. 219-223.
Shkumatov V.M., Adzerikho I.E., Lesnikovich J.A., Cherniavsky E.A. Effect of ultrasound on structure and functional properties of antithrombin III and proteins of PPSB complex // Biochemistry (Mosc), 2004. V.69. P.243–250.
Shkumatov V.M., Usova E.V, Radyuk V.G., Kashkan Zh.N., Kovganko N.V., Yuretzek T., Mauersberger S. Oxidation of 17alpha,20beta- and 17alpha,20alpha-dihydroxysipregn-4-en-ones--side products of biotransformation of progesterone by recombinant microorganisms expressing cytochrome P45017alpha// Bioorg Khim, 2003. V.29. P.640–647.
Nazarov P.A., Drutsa V.I., Miller W.L., Shkumatov V.M., Luzikov V.N., Novikova V.A. / Formation and functioning of fused cholesterol side-chain cleavage enzymes// DNA Cell Biol. – 2003. – V. 22. – P.243-252.
Lesnikovich Iu.A., Adzerokho I.E., Shkumatov V.M. Structure-functional change in streptokinase exposed to ultrasound // Biomed Khim., 2003. V.49. P.183–190.
Shkumatov V.M., Usova E.V., Poljakov Y.S., Frolova N.S., Radyuk V.G., Mauersberger S., Chernogolov A.A., Honeck H., Schunck W.-H. / Biotransformation of steroids by a recombinant yeast strain expressing bovine cytochrome P-45017a.// Biochemistry (Mosс.) – 2002. – V. 67, P.547-560.
Juvonen R.-O., Shkumatov V.M., Lang M.A. / Purification and characterization of a liver microsomal cytochrome p450 isoenzyme with a high affinity and metabolic capacity for coumarin rfom pyrasole treated D2 mice// Eur. J. Biochem. - 1988. – V.171. – P. 205-211.
Shkumatov V.M., Smettan G., Ristau O., Rein H., Ruckpaul K., Chashchin V.L., Akhrem A.A. / Quantitation of interaction between cytochrome P450scc and adrenodoxin – analysis in the median UV-region by second derivative spectroscopy// Chem-Biol. Interact. – 1988. – V.68. – P. 71-83.
Shkumatov V.M., Usanov S.A., Chashchin V.L., Akhrem A.A. / Cytochrome P450 dependent pathways in corticosteroid hormone biosynthesis// Pharmazie. – 1985. – V.10. – P. 757-766.
Chashchin V.L., Vasilevsky V.I., Shkumatov V.M., Akhrem A.A. / The domain structure of the cholesterol side chain cleavage cytochrome P450 from adrenocortical mitochondria// Biochem. Biophys. Acta. -1984. – V.787. – P. 27-38.
Akhrem A.A., Lapko V.N., Lapko A.G., Shkumatov V.M., Chashchin V.L. / Isolation, structural organization and mechanism of action of mitochondrial hydroxylating systems// Acta biol. Med. Germ. -1979. V.38. P.257-273.
ShkumatovV.M., AdzerikhoI.E., LesnikovichJ.A., CherniavskyE.A. Effect of ultrasound on structure and functional properties of antithrombin III and proteins of PPSB complex // Biochemistry (Mosc), 2004. V.69. P.243–250.
LesnikovichIu.A., AdzerokhoI.E., ShkumatovV.M. Structure-functional change in streptokinase exposed to ultrasound // Biomed Khim., 2003. V.49. P.183–190.

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