Source: https://people.healthsciences.ucla.edu/institution/personnel?personnel_id=45428
Timestamp: 2019-04-18 15:13:06+00:00

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650 Charles E Young Dr.
Dr. Yibin Wang is currently a Professor of Molecular Medicine in the David Geffen School of Medicine at UCLA. He is the Vice Chair for Molecular, Cellular and Integrated Physiology Interdepartmental Ph.D. Program. Dr. Wang received his Ph.D. in molecular genetics and cell biology from Baylor College of Medicine and post-doctoral training in neurobiology and molecular cardiology at The Scripps Research Institute and University of California at San Diego. Dr. Wang’s research mainly focuses on genetic and molecular mechanisms of heart failure and metabolic disorders. His lab has made major advances in uncovering stress-signaling mechanisms in the pathogenesis of heart failure, and revealed functional importance amino acids catabolism in heart failure and metabolic disorders. In addition, his lab reported novel regulatory mechanisms in cardiac transcriptome reprogramming involving RNA splicing regulation and non-coding RNA mediated epigenetic modulation. He has published over 198 peer-reviewed manuscripts in high quality scientific journals, including Nature Medicine, Journal of Clinical Investigation, Circulation, Circulation Research, and PNAS. Dr. Wang received an Established Investigator Award from American Heart Association in 2005. He was awarded the title of Chang-Jiang Scholar from Minister of Education of China in 2009, and Chinese National Expert for “Thousand Talent Plan” in 2011. He currently serves in the editorial board of Journal of Biological Chemistry, Circulation Research, and Journal of Molecular and Cellular Cardiology. Dr. Wang is a member of the leadership committees for AHA and ISHR North American Section. He has served in more than 30 Ph.D. thesis committees, and is currently the course master and Associate Director of the Molecular, Cellular and Integrated Physiology Ph.D. program at UCLA. Dr. Wang has 4 patents filed and 3 licensed, and he is the scientific co-founder of Ramino Biotherapeutics Inc, a start-up company focusing on novel therapies for cardiometabolic diseases.
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Park Shuin, Ranjbarvaziri Sara, Lay Fides D, Zhao Peng, Miller Mark J, Dhaliwal Jasmeet S, Huertas-Vazquez Adriana, Wu Xiuju, Qiao Rong, Soffer Justin M, Rau Christoph, Wang Yibin, Mikkola Hanna K A, Lusis Aldons J, Ardehali Reza Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis Circulation, 2018; 138(12): 1224-1235.
Lue Yanhe, Gao Chen, Swerdloff Ronald, Hoang James, Avetisyan Rozeta, Jia Yue, Rao Meng, Ren Shuxun, Atienza Vince, Yu Junyi, Zhang Ye, Chen Mengping, Song Yang, Wang Yibin, Wang Christina Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity American journal of physiology. Heart and circulatory physiology, 2018; 315(3): H634-H643.
Steiger DeAnna, Yokota Tomohiro, Li Jin, Ren Shuxun, Minamisawa Susumu, Wang Yibin The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure The Journal of biological chemistry, 2018; 293(25): 9652-9661.
Santolini Marc, Romay Milagros C, Yukhtman Clara L, Rau Christoph D, Ren Shuxun, Saucerman Jeffrey J, Wang Jessica J, Weiss James N, Wang Yibin, Lusis Aldons J, Karma Alain A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure NPJ systems biology and applications, 2018; 4(5): 12.
Wang Yan, Xie Yinping, Li Lili, He Yuan, Zheng Di, Yu Pengcheng, Yu Ling, Tang Lixu, Wang Yibin, Wang Zhihua EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs Current gene therapy, 2018; 18(5): 275-285.
Liu Yunxia, Dong Weibing, Shao Jing, Wang Yibin, Zhou Meiyi, Sun Haipeng Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway Frontiers in physiology, 2017; 8(65): 853.
Gao Chen, Wang Yibin Untangle a Broken Heart via Janus Kinase 1 Circulation research, 2017; 121(6): 589-590.
Touma Marlin, Kang Xuedong, Gao Fuying, Zhao Yan, Cass Ashley A, Biniwale Reshma, Xiao Xinshu, Eghbali Mansuoreh, Coppola Giovanni, Reemtsen Brian, Wang Yibin Wnt11 regulates cardiac chamber development and disease during perinatal maturation JCI insight, 2017; 2(17): .
Rosa-Garrido Manuel, Chapski Douglas J, Schmitt Anthony D, Kimball Todd H, Karbassi Elaheh, Monte Emma, Balderas Enrique, Pellegrini Matteo, Shih Tsai-Ting, Soehalim Elizabeth, Liem David A, Ping Peipei, Galjart Niels J, Ren Shuxun, Wang Yibin, Ren Bing, Vondriska Thomas M High Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure Circulation, 2017; 23(46): 11175.
Shimizu Hirohito, Langenbacher Adam D, Huang Jie, Wang Kevin, Otto Georg, Geisler Robert, Wang Yibin, Chen Jau-Nian The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes eLife, 2017; 6(6): 589-590.
Touma Marlin, Reemtsen Brian, Halnon Nancy, Alejos Juan, Finn J Paul, Nelson Stanley F, Wang Yibin A Path to Implement Precision Child Health Cardiovascular Medicine Frontiers in cardiovascular medicine, 2017; 4(4): 36.
Rose Beth A, Yokota Tomohiro, Chintalgattu Vishnu, Ren Shuxun, Iruela-Arispe Luisa, Khakoo Aarif Y, Minamisawa Susumu, Wang Yibin Cardiac Myocyte p38Î± Kinase Regulates Angiogenesis via Myocyte-Endothelial Cell Cross-talk During Stress-Induced Remodeling in Heart The Journal of biological chemistry, 2017; 21(4): 817-827.
Gao Chen, Howard-Quijano Kimberly, Rau Christoph, Takamiya Tatsuo, Song Yang, Shivkumar Kalyanam, Wang Yibin, Mahajan Aman Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction PloS one, 2017; 12(5): e0177750.
Seldin Marcus M, Kim Eric D, Romay Milagros C, Li Shen, Rau Christoph D, Wang Jessica J, Krishnan Karthickeyan Chella, Wang Yibin, Deb Arjun, Lusis Aldons J A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response American journal of physiology. Heart and circulatory physiology, 2017; 312(4): H728-H741.
Cong Qian, Jia Hao, Li Ping, Qiu Shoutao, Yeh James, Wang Yibin, Zhang Zhen-Lin, Ao Junping, Li Baojie, Liu Huijuan p38Î± MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner Scientific reports, 2017; 7(5): 45964.
Akaike Toru, Du Na, Lu Gang, Minamisawa Susumu, Wang Yibin, Ruan Hongmei A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart JACC. Basic to translational science, 2017; 2(2): 160-180.
Pillai Indulekha C L, Li Shen, Romay Milagros, Lam Larry, Lu Yan, Huang Jie, Dillard Nathaniel, Zemanova Marketa, Rubbi Liudmilla, Wang Yibin, Lee Jason, Xia Ming, Liang Owen, Xie Ya-Hong, Pellegrini Matteo, Lusis Aldons J, Deb Arjun Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification Cell stem cell, 2017; 20(2): 218-232.e5.
Ding Yichen, Lee Juhyun, Ma Jianguo, Sung Kevin, Yokota Tomohiro, Singh Neha, Dooraghi Mojdeh, Abiri Parinaz, Wang Yibin, Kulkarni Rajan P, Nakano Atsushi, Nguyen Thao P, Fei Peng, Hsiai Tzung K Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution Scientific reports, 2017; 7(3): 42209.
Rau Christoph D, Romay Milagros C, Tuteryan Mary, Wang Jessica J-C, Santolini Marc, Ren Shuxun, Karma Alain, Weiss James N, Wang Yibin, Lusis Aldons J Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice Cell systems, 2017; 4(1): 121-128.e4.
Sun Haipeng, Wang Yibin Branched chain amino acid metabolic reprogramming in heart failure Biochimica et biophysica acta, 2016; 1862(12): 2270-2275.
Dong Weibing, Zhou Meiyi, Dong Mei, Pan Bangfen, Liu Yunxia, Shao Jing, Gu Xiaoping, Huang Ying, Li Guangping, Wang Yibin, Sun Haipeng Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury Journal of molecular and cellular cardiology, 2016; 101(12): 90-98.
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Franklin Sarah, Kimball Todd, Rasmussen Tara L, Rosa-Garrido Manuel, Chen Haodong, Tran Tam, Miller Mickey R, Gray Ricardo, Jiang Shanxi, Ren Shuxun, Wang Yibin, Tucker Haley O, Vondriska Thomas M The chromatin-binding protein Smyd1 restricts adult mammalian heart growth American journal of physiology. Heart and circulatory physiology, 2016; 311(5): H1234-H1247.
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Touma Marlin, Kang Xuedong, Zhao Yan, Cass Ashley A, Gao Fuying, Biniwale Reshma, Coppola Giovanni, Xiao Xinshu, Reemtsen Brian, Wang Yibin Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery Circulation. Cardiovascular genetics, 2016; 9(5): 395-407.
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Wang Zhihua, Zhang Xiao-Jing, Ji Yan-Xiao, Zhang Peng, Deng Ke-Qiong, Gong Jun, Ren Shuxun, Wang Xinghua, Chen Iris, Wang He, Gao Chen, Yokota Tomohiro, Ang Yen Sin, Li Shen, Cass Ashley, Vondriska Thomas M, Li Guangping, Deb Arjun, Srivastava Deepak, Yang Huang-Tian, Xiao Xinshu, Li Hongliang, Wang Yibin The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy Nature medicine, 2016; 22(10): 1131-1139.
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Sun Haipeng, Olson Kristine C, Gao Chen, Prosdocimo Domenick A, Zhou Meiyi, Wang Zhihua, Jeyaraj Darwin, Youn Ji-Youn, Ren Shuxun, Liu Yunxia, Rau Christoph D, Shah Svati, Ilkayeva Olga, Gui Wen-Jun, William Noelle S, Wynn R Max, Newgard Christopher B, Cai Hua, Xiao Xinshu, Chuang David T, Schulze Paul Christian, Lynch Christopher, Jain Mukesh K, Wang Yibin Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure Circulation, 2016; 133(21): 2038-49.
Gao Chen, Wang Yibin Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy Hypertension (Dallas, Tex. : 1979), 2016; 67(5): 841-2.
Cong, Q.; Jia, H.; Biswas, S.; Li, P.; Qiu, S.; Deng, Q.; Guo, X.; Ma, G.; Ling Chau, J. F.; Wang, Y.; Zhang, Z. L.; Jiang, X.; Liu, H.; Li, B. p38alpha MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions, Stem Cell Reports, 2016; 6(4): 566-78.
Cong Qian, Jia Hao, Biswas Soma, Li Ping, Qiu Shoutao, Deng Qi, Guo Xizhi, Ma Gang, Ling Chau Jenny Fang, Wang Yibin, Zhang Zhen-Lin, Jiang Xinquan, Liu Huijuan, Li Baojie p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions Stem cell reports, 2016; 6(4): 566-78.
Chen, H.; Orozco, L. D.; Wang, J.; Rau, C. D.; Rubbi, L.; Ren, S.; Wang, Y.; Pellegrini, M.; Lusis, A. J.; Vondriska, T. M. DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States, Circ Res, 2016; 118(5): 786-97.
Chen Haodong, Orozco Luz D, Wang Jessica, Rau Christoph D, Rubbi Liudmilla, Ren Shuxun, Wang Yibin, Pellegrini Matteo, Lusis Aldons J, Vondriska Thomas M DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States Circulation research, 2016; 118(5): 786-97.
Iorga, A.; Li, J.; Sharma, S.; Umar, S.; Bopassa, J. C.; Nadadur, R. D.; Centala, A.; Ren, S.; Saito, T.; Toro, L.; Wang, Y.; Stefani, E.; Eghbali, M. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy, J Am Heart Assoc, 2016; 5(1): .
Yokota, Tomohiro; Wang, Yibin p38 MAP kinases in the heart, Gene, 2016; 575(2): 369-376.
Gao Chen, Ren Shuxun, Lee Jae-Hyung, Qiu Jinsong, Chapski Douglas J, Rau Christoph D, Zhou Yu, Abdellatif Maha, Nakano Astushi, Vondriska Thomas M, Xiao Xinshu, Fu Xiang-Dong, Chen Jau-Nian, Wang Yibin RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure The Journal of clinical investigation, 2016; 126(1): 195-206.
Iorga Andrea, Li Jingyuan, Sharma Salil, Umar Soban, Bopassa Jean C, Nadadur Rangarajan D, Centala Alexander, Ren Shuxun, Saito Tomoaki, Toro Ligia, Wang Yibin, Stefani Enrico, Eghbali Mansoureh Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy Journal of the American Heart Association, 2016; 5(1): 361-6.
Yokota Tomohiro, Wang Yibin p38 MAP kinases in the heart Gene, 2016; 575(2 Pt 2): 369-76.
Sun, H.; Wang, Y. The elusive philosopher's stone in young blood, Circ Res, 2015; 117(11): 906-8.
Feng Jiaying, Gong Danyang, Fu Xudong, Wu Ting-ting, Wang Jane, Chang Jennifer, Zhou Jingting, Lu Gang, Wang Yibin, Sun Ren M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production Scientific reports, 2015; 5(52): 17228.
Sun Haipeng, Wang Yibin The elusive philosopher's stone in young blood Circulation research, 2015; 117(11): 906-8.
Cattin, M. E.; Wang, J.; Weldrick, J. J.; Roeske, C. L.; Mak, E.; Thorn, S. L.; DaSilva, J. N.; Wang, Y.; Lusis, A. J.; Burgon, P. G. Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation, J Biol Chem, 2015; 290(44): 26699-714.
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Neelankavil Jacques, Rau Christoph D, Wang Yibin The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets Journal of cardiothoracic and vascular anesthesia, 2015; 29(5): 1328-32.
Sun, H.; Gao, C.; Wang, Y. A H(a)rd Way to Adapt in Cardiac Hypertrophy, Circ Res, 2015; 117(6): 484-6.
Sun Haipeng, Gao Chen, Wang Yibin A H(a)rd Way to Adapt in Cardiac Hypertrophy Circulation research, 2015; 117(6): 484-6.
Song Yang, Zhang Yonghong, Jiang Haoxiang, Zhu Yanting, Liu Lu, Feng Wei, Yang Lan, Wang Yibin, Li Manxiang Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway FEBS open bio, 2015; 5(6): 656-60.
Rau Christoph D, Parks Brian, Wang Yibin, Eskin Eleazar, Simecek Petr, Churchill Gary A, Lusis Aldons J High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping G3 (Bethesda, Md.), 2015; 5(10): 2021-6.
Rau Christoph D, Lusis Aldons J, Wang Yibin Genetics of common forms of heart failure: challenges and potential solutions Current opinion in cardiology, 2015; 30(3): 222-7.
Deb, A.; Wang, Y. Hypertrophic preconditioning: short-term tricks for long-term gain, Circulation, 2015; 131(17): 1468-70.
Deb Arjun, Wang Yibin Hypertrophic preconditioning: short-term tricks for long-term gain Circulation, 2015; 131(17): 1468-70.
Cai Rong, Gu Jianmin, Sun Haipeng, Liu Xiaobing, Mei Wenhan, Qi Yitao, Xue Song, Ren Shuxun, Rabinowitz Joseph E, Wang Yibin, Yeh Edward T H, Cheng Jinke Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy Journal of molecular and cellular cardiology, 2015; 79(1): 115-22.
Rau Christoph D, Wang Jessica, Avetisyan Rozeta, Romay Milagros C, Martin Lisa, Ren Shuxun, Wang Yibin, Lusis Aldons J Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice Circulation. Cardiovascular genetics, 2015; 8(1): 40-9.
Wang, Z.; Wang, Y. Dawn of the Epi-LncRNAs: new path from Myheart, Circ Res, 2015; 116(2): 235-6.
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Briot, A.; Jaroszewicz, A.; Warren, C. M.; Lu, J.; Touma, M.; Rudat, C.; Hofmann, J. J.; Airik, R.; Weinmaster, G.; Lyons, K.; Wang, Y.; Kispert, A.; Pellegrini, M.; Iruela-Arispe, M. L. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells, Dev Cell, 2014; 31(6): 707-21.
Ren Shuxun, Lu Gang, Ota Asuka, Zhou Z Hong, Vondriska Thomas M, Lane Timothy F, Wang Yibin IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland PloS one, 2014; 9(11): e111606.
Briot Anaïs, Jaroszewicz Artur, Warren Carmen M, Lu Jing, Touma Marlin, Rudat Carsten, Hofmann Jennifer J, Airik Rannar, Weinmaster Gerry, Lyons Karen, Wang Yibin, Kispert Andreas, Pellegrini Matteo, Iruela-Arispe M Luisa Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells Developmental cell, 2014; 31(6): 707-21.
Sun Haipeng, Wang Yibin Interferon regulatory factors in heart: stress response beyond inflammation Hypertension (Dallas, Tex. : 1979), 2014; 63(4): 663-4.
Wang, Y. Blind dates in sciences: dealing with rejection in peer review, Circ Res, 2014; 114(6): 944-6.
Xiao, X. G.; Touma, M.; Wang, Y. Decoding the noncoding transcripts in human heart failure, Circulation, 2014; 129(9): 958-60.
Wang Yibin Blind dates in sciences: dealing with rejection in peer review Circulation research, 2014; 114(6): 944-6.
Xiao Xinshu Grace, Touma Marlin, Wang Yibin Decoding the noncoding transcripts in human heart failure Circulation, 2014; 129(9): 958-60.
Gao Chen, Wang Yibin Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome Circulation journal : official journal of the Japanese Circulation Society, 2014; 78(5): 1038-47.
Gupta Ashish, Rohlfsen Cory, Leppo Michelle K, Chacko Vadappuram P, Wang Yibin, Steenbergen Charles, Weiss Robert G Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity PloS one, 2013; 8(10): e74675.
Monte Emma, Mouillesseaux Kevin, Chen Haodong, Kimball Todd, Ren Shuxun, Wang Yibin, Chen Jau-Nian, Vondriska Thomas M, Franklin Sarah Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes American journal of physiology. Heart and circulatory physiology, 2013; 305(11): H1624-38.
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Foster William H, Langenbacher Adam, Gao Chen, Chen Jaunian, Wang Yibin Nuclear phosphatase PPM1G in cellular survival and neural development Developmental dynamics : an official publication of the American Association of Anatomists, 2013; 242(9): 1101-9.
Force, T.; Wang, Y. Mechanism-based engineering against anthracycline cardiotoxicity, Circulation, 2013; 128(2): 98-100.
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Ahuja, P.; Wanagat, J.; Wang, Z.; Wang, Y.; Liem, D. A.; Ping, P.; Antoshechkin, I. A.; Margulies, K. B.; Maclellan, W. R. Divergent mitochondrial biogenesis responses in human cardiomyopathy, Circulation, 2013; 127(19): 1957-67.
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Hajjar, R. J.; Leri, A.; Wang, Y. BCVS scientific conference 2012 meeting report, Circ Res, 2012; 111(9): 1121-4.
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Akki, A.; Su, J.; Yano, T.; Gupta, A.; Wang, Y.; Leppo, M. K.; Chacko, V. P.; Steenbergen, C.; Weiss, R. G. Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium, Am J Physiol Heart Circ Physiol, 2012; 303(7): H844-52.
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Gao Chen, Wang Yibin Global impact of RNA splicing on transcriptome remodeling in the heart Journal of Zhejiang University. Science. B, 2012; 13(8): 603-8.
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