Source: http://ifoch.by/en/structure/laboratory-of-bioconjugate-chemistry.html
Timestamp: 2019-04-23 20:08:26+00:00

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The Laboratory of Bioconjugate Chemistry was founded in 2011 as the successor of the Group of Molecular Biotechnology at the Institute of Physical Organic Chemistry, the National Academy of Sciences of Belarus.
the development of novel approaches and methods for immobilization of biomolecules for affinity chromatography, affinity LDI-TOF mass spectrometry, DNA and protein chips, etc., as well as for binding biomolecules to nanoparticles and other biological and biologically active molecules.
Synthesis of the reagents for introduction of stable isotopes into biomolecules as mass spectrometric labels for proteomics and metabolomics.
synthesis of fatty acids, reinforced with deuterium.
Direct synthesis of biomolecules: The methods of synthesis of polyunsaturated fatty acids containing deuterium instead of protium in bis-allylic positions to enhance the body's resistance to oxidative stress are developed; The methods for obtaining the analogues of L-lysine containing deuterium instead of protium in positions 5 or 6 are developed.
The development of high-effective methods of analysis of point mutations of DNA.
2005-2007.	“Modifikation von Oberflächen zur Fixierung von Antikörpern zur selektiven Darstellung post-translationaler Modifikationen und Protein-Protein-Wechselwirkungen von diagnostisch relevanten Proteinen (“Biomarkern“)“. «Surface modification for fixing antibodies for the analysis of post-translational modifications and protein-protein interactions diagnostically relevant proteins (biomarkers)» Partner in Germany: BioAnalyt GmbH Source of financing: “Otto-von-Guericke“ e.V. (AiF), grant ProINNO II.
2008-2009.	Pro Inno II-Projekt «Verfahren zum Nachweis von Eisen aus Vollblut” (“EisenEx“). "Development of a method for the detection of iron from whole blood." Partner in Germany: Potsdam University. Source of financing: “Otto-von-Guericke“ e.V. (AiF), grant ProINNO II.
2009-2011.	“Entwicklung von Bio-affinittätsober-flächen zum Nachweis von Proteom-Biomarkern zur Vorhersage, Diagnose und Verlaufsbestimmung von Erkrankungen“ "The development of bioaffinn surfaces as a means of detecting biomarkers to predict, diagnose and monitor diseases" Partner in Germany: Potsdam University. Source of financing: Bundesministerium für Bildung und Forschung (BMBF), grant BLR002/09.
2011.	Seminar in the Okland University (New Zealand) “A toolbox of reagents and materials for biochemistry, molecular biology, , proteomics and metabolomics“.
Hill S, Lamberson CR, Xu L, To R, Tsui HS, Shmanai VV, Bekish AV, Awad AM, Marbois BN, Cantor CR, Porter NA, Clarke CF, Shchepinov MS..
Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation.
D.Y. Ryazantsev, D.A. Tsybulsky, I.A. Prokhorenko, M.V. Kvach, Y.V. Martynenko, P.M. Philipchenko, V.V. Shmanai, V.A. Korshun, S.K. Zavriev.
Two-dye and one- or two-quencher DNA probes for real-time PCR assay: synthesis and comparison with a TaqMan™ probe.
Tsybulsky D.A., Kvach M.V., Stepanova I.A., Korshun V.A., Shmanai V.V..
4',5'-Dichloro-2',7'-dimethoxy-5(6)-carboxyfluorescein (JOE): Synthesis and Spectral Properties of Oligonucleotide Conjugates.
Hill S., Hirano K., Shmanai V., Marbois B., Vidovic D., Bekish A., Kay B., Tse V., Fine J., Clarke C., Shchepinov M.
Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress.
Pestov N., Okkelman I., Shmanai V., Hurski A., Giaccia A., Shchepinov M.
Control of lysyl oxidase activity through site-specific deuteration of lysine.
M. Kvach, I. Stepanova, I. Prokhorenko, A. Stupak, D. Bolibrukh, V. Korshun, V. Shmanai.
Practical Synthesis of Isomerically Pure 5- 6-Carboxytetramethylrhodamines, Useful Dyes for DNA Probes.
K. Birikh, P. Bernad, V. Shmanai, A. Malakhov, M. Shchepinov V. Korshun.
SNP Detection Using Trityl Mass-Tags.
A. Ustinov, V. Shmanai, K Patel, I. Stepanova, I. Prokhorenko, I. Astakhova, A. Malakhov, M. Skorobogatyi, P. Bernad, Jr, S. Khan, M. Shahgholi, E. Southern, V. Korshun, M. Shchepinov.
Reactive Trityl Derivatives: Stabilized Carbocation Mass-tags for Life Sciences Applications.
M. Kvach, M. Skorobogatyi, A. Malakhov, A. Ustinov, I. Stepanova, V. Shmanai, V. Korshun.
Convenient synthesis of cyanine dyes: reagents for labeling of biomolecules.
M. Kvach, D. Tsybulsky, A. Ustinov, I. Stepanova, S. Bondarev, S. Gontarev, V. Korshun, V. Shmanai.
5(6)-Carboxyfluorescein revisited: new protecting group, separation of isomers, their spectral properties on oligonucleotides.
V. Shmanai, S. Gontarev, S. Frey, F. Schweigert.
Modified aluminium chips for affinity laser desorption ionization mass spectroscopy.
S. Gontarev, V. Shmanai, S. Frey, M. Kvach, F. Schweigert.
Application of phenylboronic acid modified hydrogel affinity chips for high-throughput mass spectrometric analysis of glycated proteins.
M. Kvach, I. Prokhorenko, A. Ustinov, S. Gontarev, V. Korshun, V. Shmanai.
Reagents for the selective immobilization of oligonucleotides on solid supports.
M. Skorobogatyi, M. Kvach, M. Zhylinskaya, D. Yarmolinsky, V. Korshun V. Shmanai.
5-Arylethynyl-2′- deoxyuridines: energy transfer and SNP detection.
Reagents for the selective conjugation of oligonucleotides.
International Roundtable on Nucleosides, Nucleotides Nucleic Acids. 2006, 137.
Through-stack energy transfer for SNP detection.
International Roundtable on Nucleosides, Nucleotides Nucleic Acids. 2006, 121.
M. Kvach, S. Gontarev, I. Prokhorenko, I. Stepanova, V. Shmanai, V. Korshun.
Simple reagent for the synthesis of oligonucleotides labeled with 3,3,3',3'-tetramethyl-2,2'-indodicarbocyanine.
Russ. Chem. Bull. Interntional Ed. 2006. -Vol. 55, №. 1, pp.159-163.
Solid-phase macrosupports for immunoassay modified with polysaccharides.
Shmanai V. Nikolayeva T., Vinokurova L., Litoshka A.
Oriented antibody immobilization to polystyrene macrocarriers for immunoassay modified with hydrazide derivatives of poly(meth)acrylic acid.
Proteins immobilization on formylated polystyrene supports.
Blocking of non-specific sorption in ELISA on formylated polystyrene beads.
Kvach M., Tsybulsky D., Shmanai V., Prokhorenko I., Stepanova I., Korshun V.
Nucleoside Phosphoramidites of Xanthene Dyes (FAM, JOE, and TAMRA) for Oligonucleotide Labeling.

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