Source: http://symmys.fi/matej.html
Timestamp: 2019-04-23 21:13:37+00:00

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Horizon 2020 programme (EU); Advisory Group member, Societal Challenge 1 'Health, demographic change and wellbeing' [2013-present] (See Advisory Group report from June 2016 and Advisory Group report from July 2014).
Book edited by M. Orešič and A. Vidal-Puig: A Systems Biology Approach to Study Metabolic Syndrome (Springer Verlag, NY, 2013; ISBN 978-3-319-01007-6).
Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Holm JB, Trošt K, Consortium M, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 2016; 535:376-81.
Greiner TU, Hyötyläinen T, Knip M, Bäckhed F, Orešič M. The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice. PLoS One. 2014 Nov 12;9(11):e110359. doi: 10.1371/journal.pone.0110359. eCollection 2014. PubMed PMID: 25390735.
D. La Torre, T. Seppänen-Laakso, H. E. Larsson, T. Hyötyläinen, S. A. Ivarsson, Å. Lernmark, M. Orešič, the DiPiS study group, Decreased cord-blood phospholipids in young age at onset type 1 diabetes, Diabetes 62, 3951-3956 (2013).
M. Orešič, T. Hyötyläinen, A. Kotronen, P. Gopalacharyulu, H. Nygren, J. Arola, S. Castillo, I. Mattila, A. Hakkarainen, R. J.H. Borra, M.-J. Honka, A. Verrijken, S. Francque, P. Iozzo, M. Leivonen, N. Jaser, A. Juuti, T. I. A. Sørensen, P. Nuutila, L. Van Gaal, H. Yki-Järvinen, Prediction of non-alcoholic fatty liver disease and liver fat content by serum molecular lipids, Diabetologia 56, 2266-2274 (2013).
S. I. Sayin, A. Wahlström, J. Felin, S. Jäntti, H.-U. Marschall, K. Bamberg, B. Angelin, T. Hyötyläinen, M. Orešič, F. Bäckhed, Gut microbiota regulates bile acid metabolism by reducing the levels of taurobetamuricholic acid, a naturally occurring FXR antagonist, Cell Metab. 17, 225–235 (2013).
T. Hyötyläinen, I. Mattila, S. Wiedmer, A. Koivuniemi, M.-R. Taskinen, H. Yki-Järvinen, M. Orešič, Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance, Mol. Biosyst. 8, 2559-2565 (2012).
M. Orešič, T. Seppänen-Laakso, D. Sun, J. Tang, S. Therman, R. Viehman, U. Mustonen, T. G. M. van Erp, T. Hyötyläinen, P. Thompson, A. W. Toga, M. O. Huttunen, J. Suvisaari, J. Kaprio, J. Lönnqvist, T. D. Cannon, Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia, Genome Med. 4, e1 (2012).
M. Sysi-Aho, A. Ermolov, P. V. Gopalacharyulu, A. Tripathi, T. Seppänen-Laakso, J. Maukonen, I. Mattila, S. T. Ruohonen, L. Vähätalo, L. Yetukuri, T. Härkönen, E. Lindfors, J. Nikkilä, J. Ilonen, O. Simell, M. Saarela, M. Knip, S. Kaski, E. Savontaus, M. Orešič, Metabolic regulation in progression to autoimmune diabetes, PLoS Comp. Biol. 7 (10), e1002257 (2011).
L. Yetukuri, I. Huopaniemi, A. Koivuniemi, M. Maranghi, A. Hiukka, H. Nygren, S. Kaski, M.-R. Taskinen, I. Vattulainen, M. Jauhiainen, M. Orešič, High Density Lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy, PLoS ONE 6(8), 23589 (2011).
M. Orešič, J. Tang, T. Seppänen-Laakso, I. Mattila, S. E. Saarni, S. I. Saarni, J. Lönnqvist, M. Sysi-Aho, T. Hyötyläinen, J. Perälä, J. Suvisaari, Metabolome in schizophrenia and other psychotic disorders: a general population-based study, Genome Med. 3, e19 (2011).
M. Hilvo, C. Denkert, L. Lehtinen, B. Müller, S. Brockmöller, T. Seppänen-Laakso, J. Budczies, E. Bucher, L. Yetukuri, S. Castillo, E. Berg, H. Nygren, M. Sysi-Aho, J. L. Griffin, O. Fiehn, S. Loibl, C. Richter-Ehrenstein, C. Radke, T. Hyötyläinen, O. Kallioniemi, K. Iljin, M. Orešič, Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression, Cancer Res. 71, 3236-3245 (2011).
M. Sysi-Aho, J. Koikkalainen, T. Seppänen-Laakso, M. Kaartinen, J. Kuusisto, K. Peuhkurinen, S. Kärkkäinen, M. Antila, K. Lauerma, E. Reissell, R. Jurkko, J. Lötjönen, T. Heliö, M. Orešič, Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy, PLoS ONE 6, e15744 (2011).
T. Pluskal, S. Castillo, A. Villar-Briones, M. Orešič, MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data, BMC Bioinformatics 11, 395 (2010).
J. Westerbacka, A. Kotronen, B. A. Fielding, J. Wahren, L. Hodson, J. Perttilä, T. Seppänen-Laakso, T. Suortti, J. Arola, R. Hultcrantz, S. Castillo, V. M. Olkkonen, K. N. Frayn, M. Orešič, H. Yki-Järvinen, Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD, Gastroenterology 139, 1961-1971 (2010).
L. Yetukuri, S. Söderlund, A. Koivuniemi, T. Seppänen-Laakso, P. S. Niemelä, M. Hyvönen, M.-R. Taskinen, I. Vattulainen, M. Jauhiainen, M. Orešič, Composition and lipid spatial distribution of High Density Lipoprotein particles in subjects with low and high HDL-cholesterol, J. Lipid Res. 51, 2341-2351 (2010).
V. R. Velagapudi, R. Hezaveh, C. S. Reigstad, P. V. Gopalacharyulu, L. Yetukuri, S. Islam, J. Felin, R. Perkins, J. Borén, M. Orešič, and Fredrik Backhed, The gut microbiota modulates host energy and lipid metabolism in mice, J. Lipid Res. 51, 1101-1112 (2010).
M. Orešič, T. Seppänen-Laakso, L. Yetukuri, F. Bäckhed, V. Hänninen, Gut microbiota affects lens and retinal lipid composition, Exp. Eye Res. 89, 604-607 (2009).
A. Kotronen, V. R. Velagapudi, L. Yetukuri, J. Westerbacka, R. Bergholm, K. Ekroos, J. Makkonen, M.-R. Taskinen, M. Orešič, H. Yki-Järvinen, Saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations, Diabetologia 52(4), 684-690 (2009).
P. V. Gopalacharyulu, V. R. Velagapudi, E. Lindfors, Eran Halperin, M. Orešič, Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast, Mol. BioSyst. 5, 276-287 (2009).
[REVIEW] M. Orešič, V. Hänninen, A. Vidal-Puig, Lipidomics: a new window to biomedical frontiers, Trends Biotechnol. 26(12), 647-652 (2008).
J. Nikkilä, M. Sysi-Aho, A. Ermolov, T. Seppänen-Laakso, O. Simell, S. Kaski, M. Orešič, Gender dependent progression of systemic metabolic states in early childhood, Mol. Syst. Biol. 4, e197 (2008).
L. Yetukuri, M. Katajamaa, G. Medina-Gomez, T. Seppänen-Laakso, A. Vidal Puig, and M. Orešič, Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis, BMC Systems Biology 1, e12 (2007).
R. Laaksonen, M. Katajamaa, H. Päivä, M. Sysi-Aho, L. Saarinen, P. Junni, D. Lütjohann, J. Smet, R. Van Coster, T. Seppänen-Laakso, T. Lehtimäki, J. Soini, M. Orešič, A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin induced changes in muscle, PLoS ONE 1(1): e97 (2006).
M. Katajamaa and M. Orešič, Processing methods for differential analysis of LC/MS profile data, BMC Bioinformatics 6:179 (2005).
M. Orešič and D. Shalloway, Specific Correlations between Relative Synonymous Codon Usage and Protein Secondary Structure, J. Mol. Biol. 281, 31-48 (1998).
M. Orešič and D. Shalloway, Hierarchical characterization of energy landscapes using Gaussian packet states, J. Chem. Phys. 101, 9844-9856 (1994).
April 2-4, 2012 Inserm workshop 214 “Metabolomics for biomedical research: where do we stand?”, Bordeaux, France.
Argentine tango (former www), sailing, go (board game).

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