Source: http://researchers.uq.edu.au/researcher/429
Timestamp: 2019-04-26 11:53:38+00:00

Document:
After completing my undergraduate and postgraduate studies at the University of Newcastle, I held a Postdoctoral Fellowship at the University of Basel (Switzerland) from 1990-2. I returned to Australia in 1993 to take up an Australian Research Council Postdoctoral Fellowship at the Australian National University (Canberra) from 1993-4. I joined The University of Queensland in 1994.
This research involves incorporating redox active enzymes with electrochemical systems such that the enzyme functions natively whilst in communication with an electrode (rather than with a natural electron transfer partner). We are currently investigating a number of systems, most from the molybdenum enzyme family that catalyse oxygen transfer reactions of both organic and inorganic substrates.
Atom transfer radical polymerisation (ATRP) is one of the most widely used 'controlled' radical polymerisation techniques and has resulted in polymers with well defined molecular weights and architectures. Our work is focused on complexes that catalyse this process by generating organic radicals from the simple reaction between a Cu(I) complex and an alkyl halide initiator. We can probe this atom transfer reaction with cyclic voltammetry and we have gained new insight to this interesting and fundamentally important reaction (collaboration with Prof. M.J. Monteiro, Australian Institute for Bioengineering and Nanotechnology, UQ).
My research interests include all aspects of coordination chemistry; particularly its relevance to the areas of electrochemistry, bioinorganic chemistry, spectroscopy and catalysis.
Enzyme electrochemistry (collaborations with several UQ and international groups).
Bernhardt, Paul V. (2009). Communication with the mononuclear molybdoenzymes: Emerging opportunities and applications in redox enzyme biosensors. In Davis, J. (Ed.), Engineering the Bioelectronic Interface: Applications to Analyte Biosensing and Protein Detection 1st ed. (pp. 1-24) Cambridge, UK: The Royal Society of Chemistry.
The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry: towards a new function for the peptide in the brain.
Solvent dependent anion dissociation limits copper(i) catalysed atom transfer reactions.
Synthesis and structural characterization of (Z)-3-[(4-chlorophenylamino) methylene] naphthalene-2(3H)-one: An enol, keto or zwitterionic tautomer?
Bernhardt, P. V. (2003) Bioelectricity: electrocatalysis and beyond. Chemistry in Australia, 70 4: 13-16.
Lovejoy, D. B., Richardson, D. R. and Bernhardt, P. V. (2000) 2-hydroxy-1-naphthaldehyde 2-methylthiosemicarbazone. Acta Crystallographica, Section C: Crystal Structure Communications, 56 .
Richardson, D. R., Becker, E. and Bernhardt, P. V. (1999) The biologically active iron chelators 2-pyridylcarboxaldehyde isonicotinoylhydrazone, 2-pyridylcarboxaldehyde benzoylhydrazone monohydrate and 2-furaldehyde isonicotinoylhydrazone. Acta Crystallographica, Section C: Crystal Structure Communications, 55 .
Marcus S.T., Bernhardt P.V., Grondahl L. and Gahan L.R. (1999) Complexes of 1-thia-4,7,10-triazacyclododecane (aneN3S): Synthesis, structure and stability constants. Polyhedron, 18 26: 3451-3460.
Rossignoli, Monica, Bernhardt, Paul V., Lawrance, Geoffrey A. and Maeder, Marcel (1997) Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)-and bis(2-methylpropane-1,2-diamine)-copper(II) ions. Australian Journal of Chemistry, 50 6: 527-534.
BERNHARDT, PV (1992) CORRECTION. Helvetica Chimica Acta, 75 2: 645-645.
Kok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. In: x, x, (). x.
Bernhardt, P. V. (2014). Mediated Molybdoenzyme Electrocatalysis. In: Abstracts - 16th International Conference on Biological Inorganic Chemistry (ICBIC). 16th International Conference on Biological Inorganic Chemistry (ICBIC), Grenoble France, (S61-S61). 22-26 July 2013.
Appleton, T. G., Begum, S., Bernhardt, P. V., Bryant, G. K. and Hoang, H. (2002). Reactions of tetramethyldiaminomethane with platinum(II) and palladium(II): Hydrolysis of coordinated ligand, and an unusual insertion of the resultant formaldehyde into a C-N bond in a strained chelate ring. In: 8th International Conference on the Chemistry of the Platinum Group Metals, Southampton, U.K., (). July, 2002.
Bernhardt, P. V. (2000). Interpreting disorder and solution structures with molecular mechanics. In: Abstracts of Papers of The American Chemical Society : 219th American Chemical Society National Meeting. 219th American Chemical Society National Meeting, San Francisco, USA, (U740-U740). 26-30 March, 2000.
Bernhardt, P. V. and Hayes, E. (1999). Macrocyclic complexes as redox-active receptors. In: J. Spencer and A. Brodie, Abstracts of IC '99 Joint Meeting of the Inorganic Division of the RACI and Inorganic and Organometallic Specialist Group of the NZ Institute of Chemistry. IC '99, Wellington, NZ, (36). 31 January - 4 February 2000.
Honeychurch, Michael and Bernhardt, Paul (2006) An Efficient Numerical Method for Simulating Electrochemically Driven Enzymatic Reactions.

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