Source: https://vavilov.elpub.ru/jour/article/view/162
Timestamp: 2019-04-19 00:24:29+00:00

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Известно, что сверхэкспрессия гена Gadd45 в нервной системе дрозофилы увеличивает продолжительность жизни. В работе проведена аппроксимация кривых выживания дрозофил в такого рода экспериментах с помощью распределения Гомпертца и показано, что продление жизни достигается за счет изменения параметра R, отражающего интенсивность гибели в начальный момент времени, а не за счет другого параметра распределения Гомпертца, α, отражающего экспоненциально растущую интенсивность гибели. Дополнительно провели анализ кривых выживания для случая радиационного гормезиса (когда облучение малыми дозами радиации вызывает продление жизни особей) и также подтвердили найденную в первом случае закономерность. На этой основе заключили, что поиск геропротекторов перспективно проводить среди веществ, уменьшающих параметр R, который более легко измерим,чем полная кривая выживания.
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