Source: http://otp-journal.com.ua/article/view/27375
Timestamp: 2019-04-24 16:14:18+00:00

Document:
Hip replacement is the most effective method of treatment of coxarthrosis of stages III–IV allowing patients to improve quality of life and to restore the ability to work. However, term of service of the prosthesis is limited. Objective: To study regeneration of bone tissue using sapphire implants with titanium coating. Methods: Samples of pure titanium coated sapphire implanted into the distal metaphysis of the femur to 9 white laboratory rats, and without any coating — to 9 animals. At 7, 14 and 30 days after surgery the area of implantation were examined by standard methods of histology with morphometry. Results: Microscopic analysis of zone of the implantation of samples showed the formation of high-grade bone regeneration according to stage-temporal characteristics of reparative osteogenesis. After 7 days connective tissue and young bony trabeculae with high density of osteoblasts on the surface formed around implants. After 14 days in the animals of both groups there was mature connective tissue in the area of defect. The newly formed bone trabeculae in some places fitted snugly to the area of implantation. On the 30th day around zone of implantation we revealed mature bone tissue adherent to the maternal bone. In some areas between the bone and the implant we determined a thin layer of connective tissue. There were not found any toxic effects of the materials used. Morphometric analysis revealed a greater (to 1.99 times) area of bone regeneration around titanium coated sapphire implants compared to uncoated samples. Conclusions: High osteoinductive properties of titanium after implantation into the distal metaphysis of the femur of the rats were confirmed. However, the presence of the connective tissue layer around the testing samples with coating and without it does not allow to say about appearance of a complete bony fusion between the bone and the implant.
Buryanov O. Metallic materials for orthopedic implants and trauma destination / O. Buryanov, M. Korzh, S. Оshkaderov // Orthopaedics, traumatology and prosthetics. — 2008. — № 3. — P. 5–10.
Biocompatibility of materials in a new generation of endoprostheses for total hip joint arthroplasty / O. Kosiakov, O. Rosenberg, V. Bondar [et al.] // Orthopaedics, traumatology and prosthetics. — 2010. — № 4. — P. 110–115.
Gaiko G. Status arthroplasty in Ukraine and its development prospects / G. Gaiko // The total revision arthroplasty and large joints. — Materials of NPC. — Kyiv-Lviv, 2003. — P. 3–7.
Justification and clinical aspects of application of the new design of the endoprosthesis with sapphire friction pair in the hip joint pathology / M. Korzh, V. Таnkut, V. Filipenko [et al.] // Vestnik SevNTU. — 2012. — Vol. 133. — P. 57–62. — (Series: Mechanics, energy, environment).
The application of modern materials in hip arthroplasty / M. Korzh, V. Filipenko, V. Таnkut [et al.]: scientific reports of XVI Congress of orthopedic trauma of Ukraine (Kharkiv, 3–5 october, 2013). — Kharkiv, 2013. — P. 600.
Condition and structure of primary disability in joint diseases / D. Yaremenko, О. Shevchenko, І. Golubeva [et al.] // Litopys of traumatology and orthopedics. — 2008. — № 1–2. — P. 133–135.
Таnkut V. Reasoning for hip replacement using single-crystal corundum in the hinge of hip prosthesis: abstract of dissertation … candidate of medical science: speciality 14.01.21 − traumatology and orthopedics / V. Таnkut. — Kharkiv, 2010. — 24 p.
Filipenko V. Questions of hip joint arthroplasty from positions of material characteristics which is used in friction pairs / V. Filipenko, V. Таnkut // Litopys of traumatology and orthopedics. — 2008. — № 1–2. — P. 226–229.
European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes. Strasbourg, 18.III.1986 [Electron resource: http://conventions.coe.int/Treaty/EN/Treaties/Html/123.htm.
Law of Ukraine №3447-IV від 21.02.2006 «On protection of animals from abuse» (Article 26).
Аndreev А. Vacuum-arc coating / А. Аndreev, L. Sablev, S. Grigoryev. — Kharkiv, NSC KIPT, 2010. — 318 p.
Trends and developments in the manufacturing of hip joints: an overview / O. A. Rozenberg, A. G. Mamalis [et al.] // Int. J. Adv. Manuf. Technol. — 2006. — Vol. 27. — P. 537–542.

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