Source: https://www.faculty.uci.edu/profile.cfm?faculty_id=4538
Timestamp: 2019-04-26 00:29:11+00:00

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Cells are highly structured, and this structure is created and maintained using the cytoskeleton in conjunction with molecular motors. My research combines genetic and biochemical manipulations with biophysical techniques ( laser-tweezers, single-particle tracking and analysis, and computer modeling) to study cargo transport in vivo. My primary goal is to understand the extent to which the activity of different molecular motors is coordinated, and the detailed physical changes in motor activity that result in alteration of net cargo transport.
61. A. Kunwar, Kunwar, S.K. Tripathy, J. Xu, M.K. Mattson, P. Anand, R. Sigua, M. Vershinin, R.J. McKenney, C. C. Yu, A. Mogilner+†, and S.P. Gross+†, “Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport”, PNAS, November 14, (2011).
59. M. Bosch, M. Marí, S.P. Gross, J.C. Fernández-Checa, and A. Pol, “Mitochondrial cholesterol: a connection between caveolin and metabolism”, Traffic (AOP) (2011).
57. J. Xu and S.P. Gross, “Biophysics of dynein in vivo” (invited review), to appear in Dyneins: Structure, Biology and Disease, (Elsevier), Editor Stephen M. King (2012).
55. G. Shubeita and S.P. Gross, , “Intracellular Transport: Relating Single-Molecule Properties to in Vivo Function” (invited review), to appear in Comprehensive Biophsics, (Elsevier), Editor Ed. Egelman (2012).
48. G. Shubeita, S. Tran, J. Xu, M. Vershinin, S. Cermelli, S. Cotton, M. Welte, and S.P. Gross, “Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets” Cell 135(6), (2008).
47. K. Larsen, J. Xu, S. Cermelli, and S.P. Gross, “BicaudalD actively regulates microtubule motor activity in lipid droplet transport.”, PLoS one 3(11), (2009).
46. A. Kunwar, M. Vershinin, J. Xu, and S.P. Gross, “Stepping, Strain Gating, and an Unexpected Force-Velocity Curve for Multiple-Motor-Based Transport”, Current Biology 18, 1–11, August 26, 2008 (2008).
45. M.A. Welte and S. P. Gross, “Molecular motors: a traffic cop within?”, HFSP Journal in press, (2008).
42. S. P. Gross, M. Vershinin and G.T. Shubeita, “Cargo Transport: Two Motors Are Sometimes Better Than One”, Curr. Bio. v.17, R478-486 (2007).
41. S. P. Gross, “Molecular Motors: A Tale of Two Filaments”, Curr. Bio. v.17, R277-280 (2007).
39. J.E. Martinez, M.D. Vershinin , G.T. Shubeita, and S.P. Gross, “On the use of in vivo cargo velocity as a biophysical marker”, Biochem. Biophys. Res. Comm. 353, 835-840 (2007).
36. S. Cermelli*, Y. Guo, S.P. Gross+† and M.A. Welte+, "The Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage Depot", Curr. Bio., v. 16, 1783-1795, (2006).
35. S. L. Bullock, A. Nicol, S.P. Gross, and D. Zicha, " Guidance of Bidirectional Motor Complexes by mRNA Cargoes through Control of Dynein Number and Activity", Curr. Bio.,V. 16, 1447–1452, (2006).
33. Roop Mallik, Dmitri Petrov, S.A. Lex, S.J. King, and S.P. Gross, "Building Complexity: An In Vitro Study of Cytoplasmic Dynein with In Vivo Implications", Curr. Bio., v. 15, 2075-2085, (2005).
31. M.A. Welte*, S. Cermelli*, J. Griner, A. Viera, Y. Guo, D. Kim, J.G. Gindhart , S.P. Gross, "Regulation of lipid-droplet transport by the Perilipin homologue LSD2", Curr. Bio., v. 15, 1266-1275, (2005).
30. F. Lin, CM Nguyen, SJ Wang, W Saadi, SP Gross, NL Jeon, "Neutrophil Migration in Opposing Chemoattractant Gradients Using Microfluidic Chemotaxis Devices", Ann. Biom. Engin., v. 33, no. 4, 475-482 (2005).
29. Brian C. Carter, George T. Shubeita, and Steven P. Gross, “ Tracking single-particles: a user-friendly quantitative evaluation", Physical Biology 2, 60–72, (2005).
28. T. del Rio, T.H. Ch’ng 2, E.A. Flood, S.P. Gross, and L.W. Enquist “ Heterogeneity of a fluorescent tegument component in single psedorabies virons and enveloped axonal assemblies", J. Virol. , n. 79, 3903-19 (2005).
27. Roop Mallik and Steven P. Gross, “Molecular Motors: Strategies to Get Along”, Current Biology, v. 14, R971-R982, (2004).
22. R. Mallik, B.C. Carter, S.A. Lex, S.J. King and S.P. Gross “Cytoplasmic dynein functions as a gear in response to load”, Nature 427, 649-52 (2004).
21. Vladimir Rodionov, Julie Yi, Anna Kashina, Abiola Oladipo, and Steven P. Gross, “Switching between microtubule- and actin-based transport systems in melanophores is controlled by cAMP levels”, Current Biology, v. 13, 1837–1847, (2003).
20. Steven P. Gross,Yi Guo, Joel E. Martinez, and Michael A. Welte, “A Determinant for Directionality of Organelle Transport in Drosophila Embryos”, Current Biology, v. 13, 1660–1668, (2003).
19. S. P. Gross, “Dynactin: Coordinating Motors with Opposite Inclinations (Dispatch)”, Current Biology, v. 13, R320-322 (2003).
18. S. P. Gross, “Application of Optical Traps In Vivo”, Methods in Enzymology, v. 361, 162-174 (2003).
17. L.J. Davis, D.J. Odde, S. M. Block, and S. P. Gross, “The Importance of Lattice Defects in Katanin-Mediated Microtubule Severing in Vitro”, Biophys. J. 82, 2916-27 (2002).
16. S. P. Gross*, M. C. Tuma*, S. W. Deacon, A. S. Serpinskaya A. R. Reilein and V. I. Gelfand, “Interactions and Regulation of Molecular Motors in Xenopus Melanophores”, J. Cell Bio. 156, 855-65 (2002).
14. L.W. Enquist, M.J. Tomishima, S. Gross, G.S. Smith, “Directional spread of an alpha-herpsesvirus in the nervous system”, Veter. Microb. 2266, 1-12 (2002).
12. S.P Gross, M. Welte, S.M. Block, and E.F. Wieschaus, “Dynein-mediated cargo transport In vivo. A switch controls travel distance.”, J. Cell Biol. 148 945-56 (2000).
11. S.P. Gross*, M. Welte*, M. Postner, S. M. Block, and E.F. Wieschaus, “Developmental and Genetic Regulation of Vesicle Transport in Drosphila Embryos”, Cell 92, 547 (1998).
10. K. Visscher, S. P. Gross, and S. M. Block, “Construction of Multiple-Beam Optical Traps with Nanometer-Resolution Position Sensing”, IEEE Jl. Sel. Top. Quant. Electr., 2, 1066 (1996).
9. E. Sharon, S. P. Gross, and J. Fineberg, “Energy Dissipation in Dynamic Fracture,” Phys. Rev. Lett., 76, 2117 (1996).
7. E. Sharon*, S. P. Gross*, and J. Fineberg, ``Local Crack Branching as a Mechanism for Instability in Dynamic Fracture,'' Phys. Rev. Lett, 74, 5096 (1995).
6. M. Marder and Steve Gross, ``Origin of Crack Tip Instabilities,'' Jl. of the Mech. and Phys. of Sol., 43, 1 (1995).
5. S. P. Gross, J. Fineberg, M. Marder, W.D. McCormick, and H. L. Swinney, ``Acoustic Emissions from Rapidly Moving Cracks," Phys. Rev. Lett., 71, 3162 (1993).
4. J. Fineberg, S. P. Gross, M. Marder, and H. L. Swinney, ``Instability in the propagation of fast cracks'', Phys. Rev. B, 45, 5146, 1992.
3. J. Fineberg, S. P. Gross, M. Marder, and H. L. Swinney, ``Instability in Dynamic Fracture,'' Phys. Rev. Lett., 67, 457, (1991).
2. S. Gross, G. Zocchi, and A. Libchaber ``Waves and Plumes of thermal boundary layer,'' C. R. Acad. Sci. Paris, 307, Serie II, 447, (1988).
1. J. Glazier, S. P. Gross, J. Stavans, ``Dynamics of two-dimensional soap froths'', Phys. Rev. A, 36, 306, 1987.

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