Source: http://eprints.glos.ac.uk/6202/
Timestamp: 2019-04-18 16:44:08+00:00

Document:
Prolonged, uninterrupted sitting negatively impacts markers of peripheral vascular health, particularly, vasodilatory function of leg arteries. Whether sitting can similarly impact measures of central vascular health, as well as overall leg vasoreactivity (i.e.,vasodilatory and vasoconstrictor function) remains unknown. To address this, measurements were made in relatively healthy participants (i.e., free of overt disease; n=20, age=26 § 7; body mass index = 30 § 7 kg/m2; 7 female) pre, during and post 3 hours of uninterrupted sitting. Measures of central vascular health included arterial wave reflection(augmentation index and Reflection Magnitude — RM%) and aortic vascular stiffness (aortic pulse velocity). Local vasoreactivity of the distal, posterior tibial artery was measured using flow-mediated dilation — FMD, coupled with low-flow mediated constriction, and microvascular function was assessed through the total hyperemic blood velocity (area-under-curve)response during FMD. After sitting, there was a significant increase in aortic pulse wave velocity (pre sit = 5.7 § 0.3 vs post sit = 6.1 § 0.3 m/s;p=0.009, d = 0.36), whereas, augmentation index decreased (pre sit = 13 § 3 vs post sit = 3 § 1%; p < 0.001, d = 0.71). Albeit a moderate effect for decrease, RM% was not significantly altered during sitting (p = 0.13, d = 0.3). Vasodilatory (i.e., FMD pre sit = 0.5 § 0.04 vs post sit =0.3 § 0.04 mm; p = 0.014, d = 0.29) and microvascular function (i.e., Microvascular area-under-curve: pre sit = 2,196 § 333 vs 1,157§172 AU; p = 0.003, d = 0.31) decreased, but vasoconstrictor function (low-flow mediated constriction; p = 0.85, d = 0.005) was unaffected by sitting. In conclusion, these data demonstrate that a prolonged bout of unin- terrupted sitting negatively impacts markers of peripheral and central vascular health in relatively healthy adults.
Revised 8 October 2018, Available online 22 October 2018. © 2018 Elsevier Inc. All rights reserved. Accepted manuscripts are Articles in Press that have been peer reviewed and accepted for publication by the Editorial Board of this publication. They have not yet been copy edited and/or formatted in the publication house style, and may not yet have the full ScienceDirect functionality, e.g., supplementary files may still need to be added, links to references may not resolve yet etc. The text could still change before final publication. Although accepted manuscripts do not have all bibliographic details available yet, they can already be cited using the year of online publication and the DOI, as follows: author(s), article title, Publication (year), DOI. Please consult the journal's reference style for the exact appearance of these elements, abbreviation of journal names and use of punctuation. When the final article is assigned to volumes/issues of the Publication, the Article in Press version will be removed and the final version will appear in the associated published volumes/issues of the Publication. The date the article was first made available online will be carried over.

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