Source: http://stem.open.ac.uk/people/mgs4
Timestamp: 2019-04-22 10:09:29+00:00

Document:
Prof. Mike Stewart is a Professor of Neuroscience in the Department of Life, Health and Chemical Sciences at the Open University. His group's recent research activities have been concerned with neurodegenerative changes in the brain in ageing, and in conditions such as Alzheimer's Disease.
Mike is involved with a number of external bodies, both nationally and internationally. He is a member of the EDAB (European Dana Alliance) and was a member of FENS (Federation of European Neuroscience Societies) executive committee from 2010-2015 and treasurer from 2012-2015. He has been a reviewer for biomedical research funding bodies in several countries, including France, Germany, Netherlands, Italy, Portugal, Poland, Romania, Australia and Hong Kong. During his career he has given lectures on his research and participated in conferences in over 20 countries world wide.
In the UK Mike has reviewed grants for a number of Research Councils, and the Wellcome trust; he was a member of the Motor Neurone Disease Research Association committee from 2010-2015, and chaired the committee from 2012-2015.
He has also led external medical education programmes doing Pro Bono work in Bangladesh in Dhaka,(2001-2006) based at BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) where he and his colleague Prof Janet Grant developed a distance learning course in Diabetology, which has been taken by over 1000 medical staff.
In Ethiopia he and Prof Grant also carried out Pro Bono work from 2007-2013 training lecturers in a new medical school, St Paul's Hospital Millennium Medical College in Addis Ababa.
His current research interest involves investigations of the morphological basis of synaptic plasticity in neural circuits in the mammalian brain. State of the art technologies are used in order to examine changes that occur at hippocampal synapses following learning paradigms, and in neurodegeneratve conditions. This research involves analysis of synaptic changes and of dendritic spine populations, as well as quantification of immediate early gene expression in order to determine the precise localisation of synaptic change in the hippocampus following learning, and in ageing and neurodegenerative conditions.
My main research interests are centred in Neuroscience - Plasticity of the vertebrate central nervous system (CNS), and the effects of ageing and neurodegeneration on the CNS.
At the Open University, my research concerns synaptic and neural plasticity. I have been particularly concerned with investigation of problems involving cellular neurobiology especially neurodegeneration and Alzheimers disease (see publication lists for further details).
I have also been involved in an industrial collaboration with Glaxo-Wellcome and NIMR (MRC- Mill Hill) which has arisen as a result of an MRC foresight link award (£660,000; OU share £330,000). This project involved investigations of the cellular and molecular basis of Alzheimer's disease, using transgenic mice in which a high risk factor for Alzheimer's disease (a human allele of a gene called apolipoprotein E -apoE) has been added (knocked-in) to mice lacking the normal apoE gene. More recently I was awarded a BBSRC Neurone grant (£440,000) as lead investigator with collaborators from UCL and NIMR (MRC), followed by an IAAB award from BBSRC with Collaborators at UCL. Additionally, my research has been supported internally via the Open University Research committee, and externally via grants from the Nuffield foundation, N.I.H. (USA), NATO and EC. British Council, Wellcome Trust and Royal Society exchange grants have also been provided to support collaborative projects with laboratories in Germany, Hungary, Poland and the FSSU.
My most recent awards include a £650K BBSRC grant with Prof Karl Kiese of Kings College London (2012-16) , and EU FPVI grants (2005) (value €9.5 million) shared with 12 partner EU laboratories and an FP7 Grant (MEMSTICK) (value €3.9 million) . This research on neurodegeneration involves study of the morphological effect of N-cell adhesion molecule (N-CAM) mimetics on structure of the hippocampus and prefrontal cortex of rats and mice, and its ability to alleviate cognitive deficits including those induced by B-amyloid which is prevalent in Alzheimer's disease.
Peddie, C., Davies, H.A., Colyer F.M; Stewart, M.G., Rodriguez, J. J. (2008) Colocalisation of serotonin 2A receptors with the glutamate receptor subunits NR1 and GluR2 in the dentate gyrus: anultrastructural study of a modulatory role. Experimental Neurology 211(2): 561-573.
Peddie, C., Davies, H.A., Colyer F.M; Stewart, M.G., Rodriguez, J. J. (2008) Dendritic colocalisation of serotonin1B receptors and the glutamate NMDA receptor subunit NR1 within the hippocampal dentate gyrus: an ultrastructural study. Journal of Chemical Neuroanatomy 36(1): 17-26.
Stewart M.G. (2008) Colostrinin™- a naturally-occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer’s. Expert Opinion on Pharmacotherapy 9 (14):2553-9.
Dalllarac, G., Doyere, CV., Davies H.A., Rodriguez-Arellano, JJ, Stewart M.G. (2009) NMDA-independent changes in expression of PSA-NCAM after induction of LTP and LTD in the rat dentate gyrus in vivo Neuron Glia Biology, 4(3):169-78.
Popov, V.I, Kraev, I.V., Banks, D., Morenkov. ED, Davies, H.A., Stewart.M.G. Fesenko, EE. (2009) Three- dimensional ultrastructural and immunohistochemical study of immature neurons in the subgranular zone of the rat dentate gyrus. Biophysics, 54 (4), 497–512.
Kraev, Igor; Henneberger, Christian; Rossetti, Clara; Conboy, Lisa; Kohler, Lene B.; Fantin, Martina; Jennings, Alistair; Venero, Cesar; Popov, Victor; Rusakov, Dmitri; Stewart, Michael; Bock, Elisabeth; Berezin, Vladimir and Sandi, Carmen (2011). A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus. PLOS One, 6(8), e23433.
Michaluk, Piotr; Wawrzyniak, Marcin; Alot, Przemyslaw; Szczot, Marcin; Wyrembek, Paulina; Mercik, Katarzyna; Medvedev, Nikolay; Wilczek, Ewa; De Roo, Mathias; Zuschratter, Werner; Muller, Dominique; Wilczynski, Grzegorz M; Mozrzymas, Jerzy W; Stewart, Michael G.; Kaczmarek, Leszek and Wlodarczyk, Jakub (2011). Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology. Journal of cell science, 124(Pt 19), pp. 3369–3380.
Ojo, Bunmi; Rezaie, Payam; Gabbott, Paul L.; Cowely, Thelma R.; Medvedev, Nikolay I.; Lynch, Marina A. and Stewart, Michael G. (2011). A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus. Experimental Neurology, 323(2), pp. 318–328.
Popov, Victor I.; Kleschevnikov, Alexander M.; Klimenko, Oleg A.; Stewart, Michael G. and Belichenko, Pavel V. (2011). Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome. Journal of Comparative Neurology, 519(7), pp. 1338–1354.
Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I.; Kraev, Igor; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian M.; Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall, Andrew D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael G. and Jones, Matt W. (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neuroscience Early Access.
Giese, Karl Peter; Aziz, Wajeeha; Kraev, Igor and Stewart, Michael G. (2015). Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation. Neurobiology of Learning and Memory (Early view).
Van der Kooij MA, Fantin M, Kraev I, Korshunova I, Grosse J, Zanoletti O, Guirado R, Garcia-Mompó C, Nacher J, Stewart MG, Berezin V, Sandi C. (2013) Impaired Hippocampal Neuroligin-2 Function by Chronic Stress or Synthetic Peptide Treatment is Linked to Social Deficits and Increased Aggression. Neuropsychopharmacology. 2013 Nov 11. doi: 10.1038/npp.2013.315.
SD206 - BIOLOGY, BRAIN AND BEHAVIOUR (1992 on) -Production of "Brain Video" funded both externally and by the Open University.
Savtchenko, Leonid P.; Bard, Lucie; Jensen, Thomas P.; Reynolds, James P.; Kraev, Igor; Medvedev, Nikolay; Stewart, Michael G.; Henneberger, Christian and Rusakov, Dmitri A.
Kraev, Igor V.; Chaudhury, Sraboni; Davies, Heather A.; Dallérac, Glenn; Doyère, Valérie and Stewart, Michael G.
Giese, Karl Peter; Aziz, Wajeeha; Kraev, Igor and Stewart, Michael G.
Brace, L. R.; Kraev, I.; Rostron, C. L.; Stewart, M. G.; Overton, P. G. and Dommett, E. J.
Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I.; Kraev, Igor; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian M.; Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall, Andrew D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael G. and Jones, Matt W.
Medvedev, Ni. I.; Dallérac, G.; Popov, V. I.; Rodriguez Arellano, J. J.; Davies, H. A.; Kraev, I. V.; Doyère, V. and Stewart, M. G.
Corbett, Nicola J.; Gabbott, Paul L.; Klementiev, Boris; Davies, Heather A.; Colyer, Frances M.; Novikova, Tatiana and Stewart, Michael G.
Gabbott, P. L. and Stewart, M. G.
Wang, Xiao-Dong; Rammes, Gerhard; Kraev, Igor; Wolf, Miriam; Liebl, Claudia; Scharf, Sebastian. H.; Rice, Courtney. J.; Wurst, Wolfgang; Holsboer, Florian; Deussing, Jan. M.; Baram, Tallie. Z.; Stewart, Michael. G.; Muller, Marianne. B. and Schmidt, Mathias. V.
Popov, Victor I.; Kleschevnikov, Alexander M.; Klimenko, Oleg A.; Stewart, Michael G. and Belichenko, Pavel V.
Popov, Victor; Kraev, Igor V.; Ignat'ev, Dimitri and Stewart, Michael G.
Medvedev, N. I.; Popov, V. I.; Dallérac, G.; Davies, H. A.; Laroche, S.; Kraev, I. V.; Roriguez Arellano, J. J.; Doyère, V. and Stewart, M. G.
Medvedev, N. I.; Popov, V. I.; Rodriguez Arellano, J. J.; Dallérac, G.; Davies, H. A.; Gabbott, P. L.; Laroche, S.; Kraev, I. V.; Doyère, V. and Stewart, M. G.
Peddie, C. J.; Davies, H. A.; Colyer, F M.; Stewart, M. G. and Rodríguez, J. J.
Popov, V. I.; Kraev, I. V.; Banks, D.; Davies, H. A.; Morenkov, E. D.; Stewart, M. G. and Fesenko, E. E.
Stewart, Michael G. and Popov, Victor I.
Kraev, Igor; Godukhin, Oleg V.; Patrushev, Ilya V.; Davies, Heather A.; Popov, Victor I. and Stewart, Michael G.
Rodríguez, J. J.; Dallérac, G. M.; Tabuchi, M.; Davies, H. A.; Colyer, F. M.; Stewart, M. G. and Doyère, V.
Peddie, C.J.; Davies, H.A.; Colyer, F.M.; Stewart, M.G. and Rodriguez, J.J.
Rodriguez, J. J.; Davies, H. A.; Errington, M. L.; Verkhratsky, A.; Bliss, T. V. P. and Stewart, M. G.
Popov, V.I.; Medvedev, N.I.; Patrushev, I.V.; Ignat'ev, D.A.; Morenkov, E.D. and Stewart, M.G.
Lauver, Aaron; Yuan, Li-Lian; Jeromin, Andreas; Nadin, Brian M.; Rodriguez, Jose J.; Davies, Heather A.; Stewart, Michael G.; Wu, Gang-Yi and Pfaffinger, Paul J.
Nikolakopoulou, A.M.; Davies, H.A. and Stewart, M.G.
Tigaret, C.M.; Thalhammer, A.; Rast, G.F.; Specht, C.G.; Auberson, Y.P.; Stewart, M.G. and Schoepfer, R.
Nikolakopoulou, A. M; Dermon, C. R.; Panagis, L.; Pavlidis, M. and Stewart, M. G.
Popov, Victor; Medvedev, Nikolai I.; Davies, Heather A. and Stewart, Michael G.
Popov, V. I.; Deev, A. A.; Klimenko, O. A.; Kraev, I. V.; Kuz'minykh, S. B.; Medvedev, N. I.; Patrushev, I. V.; Popov, R. V.; Rogachevskii, V. V.; Khutsiyan, S. S.; Stewart, M. G. and Fesenko, E. E.
Rodríguez, J. J.; Davies, H. A.; Silva, A. T.; De Souza, I. E. J.; Peddie, C. J.; Colyer, F. M.; Lancashire, C. L.; Fine, A.; Errington, M. L.; Bliss, T. V. P. and Stewart, M. G.
Mayoa, W.; Lemaire, V; Malaterre, J.; Rodriguez, J. J.; Cayre, M.; Stewart, M. G.; Kharouby, M.; Rougon, G.; Le Moal, M.; Piazza, P. V. and Abrous, D. N.
Stewart, M. G.; Davies, H. A.; Sandi, C.; Kraev, I. V.; Rogachevsky, V. V.; Peddie, C. J.; Rodriguez, J. J.; Cordero, M. I.; Donohue, H. S.; Gabbott, P. L. and Popov, V. I.
Cordero, M. I.; Rodriguez, J. J.; Davies, H. A.; Peddie, C. J.; Sandi, C. and Stewart, M. G.
Popov, V.I.; Davies, H.A.; Rogachevsky, V.V.; Patrushev, I.V.; Errington, M.L.; Gabbott, P.L.A.; Bliss, T.V.P. and Stewart, M.G.
Davies, H. A.; Kelly, A.; Dhanrajan, T. M.; Lynch, M. A. and Stewart, M. G.
Sandi, Carmen; Davies, Heather; Isabel Cordero, M.; Rodriguez, Jose J.; Popov, Victor I. and Stewart, Michael G.
Eyre, Mark D.; Richter-Levin, Gal; Avital, Avi and Stewart, Michael G.
Richardson, J.C.; Kendal, C.E.; Anderson, R.; Priest, F.; Gower, E.; Soden, P.; Gray, R.; Topps, S.; Howlett, D.R.; Lavendar, D.; Clarke, N.J.; Barnes, J.C.; Haworth, R.; Stewart, M.G. and Rupniak, H.T.R.
Dermon, C. R.; Zikopolous, B.; Panagis, L.; Harrison, E.; Lancashire, C. L.; Mileusnic, R. and Stewart, M.G.
Stewart, Michael; Eyre, M. D. and Richter-Levin, G.
Stewart, Michael G.; Popov, Victor I.; Kraev, Igor V.; Medvedev, Nikolay and Davies, Heather A.

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