Source: http://jbpe.ssau.ru/index.php/JBPE/article/view/3282
Timestamp: 2019-04-24 16:27:13+00:00

Document:
Paper #3282 received 26 Feb 2018; revised manuscript received 12 Mar 2018; accepted for publication 16 Mar 2018; published online 31 Mar 2018. [Special Section. Workshop “Biophotonics” of the XV all-Russian Youth Samara conference-contest on optics and laser physics].
We study the heating kinetics in transplanted model tumours after the intravenous injection of suspension of gold nanorods having the concentration from 400 to 1200 µg/mL under the laser irradiation at the wavelength 808 nm during 15 min. The object of study were 40 outbred white laboratory rats with transplanted liver cancer tumours (Cholangiocarcinoma PC1). The obtained results allow the optimisation of the gold nanorods injection technique at different degrees of vascularisation of tumour tissues aimed to provide the maximal heating of tumours by the laser radiation. It is shown that the maximal increase of the tumour temperature is related to the maximal accumulation of gold nanorods in the tumour tissues, observed in the case of its high vascularisation.
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