Source: https://www.pharm.stonybrook.edu/faculty/a/aguirre
Timestamp: 2019-04-22 15:57:30+00:00

Document:
Post-doctoral work, Center for Neuroscience Research, Washington D.C.
The overall goal of my lab is to understand the cellular and molecular mechanisms that regulate the transition of undifferentiated neural progenitor cells (“neural stem cells”) into specialized neural cells during normal development, and to examine how these mechanisms function in pathological situations when microenvironments are modified. To address these questions, my lab uses animal models clinically relevant to the study of neuropathological disorders along with a combination of genetic and genomic approaches, transplantation, chemical, and viral vector-based in vivo models in parallel with tissue culture studies, to examine extrinsic (environmental) and intrinsic factors that govern the differentiation of adult neural stem/precursor cells into mature functional neural cells following nervous system pathologies. In particular, we study a unique kind of neural progenitor cell defined and identified by expression of the NG2 proteoglycan (NG2-progenitor cells). NG2-progenitor cells are the most numerous progenitor cells in the nervous system and normally are found in a quiescent state. Under pathological situations, however, they are the first cells to respond, switching to an active proliferative state to expand their numbers. They subsequently exit the cell cycle at an appropriate time and differentiate. Despite their abundance, we know very little about their responsiveness to external factors under normal and pathological conditions. Taken together, we anticipate it will be possible to exploit the insights gained from our studies to use endogenous NG2-progenitor cells for cell-based replacement for a variety of brain pathologies.
Gadea A, Aguirre A, Haydar T, Gallo V. (2009) A novel role for endothelin1 as a regulator of oligodendrocyte progenitor recruitment in development and remyelination. J. Neurosci. 29, 10047-10062.
Li X, Tang X, Jablonska B, Aguirre A, Gallo V, Luskin MB. (2009) p27 (KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouse. J. Neurosci. 29, 2902-2914.
Jablonska B, Aguirre A, Vandenbosch R, Belachew S, Berthet C, Kaldis P, Gallo V. (2007) Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone. J. Cell. Biol. 179, 1231-1245.
Aguirre A, Dupree JL, Mangin JM, Gallo V. (2007) A functional role for EGFR signaling in myelination and remyelination. Nat. Neurosci. 10,990-1002.
Sohn J, Natale J, Chew LJ, Belachew B, Cheng Y, Aguirre A, Lytle J, Nait-Oumesmar B, Kerninon C, Kanai-Azuma M, Kanai Y, Gallo V. (2006) Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J. Neurosci. 26, 9722-9735.
Aguirre A, Rizvi TA, Ratner N, Gallo V. (2005) Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. Journal of Neuroscience 25, 11092-11106.
Chittajallu R, Aguirre A, Gallo V. (2005) Downregulation of platelet-derived growth factor-alpha receptor-mediated tyrosine kinase activity as a cellular mechanism for K+-channel regulation during oligodendrocyte development in situ. Journal of Neuroscience 25, 8601-8610.
Hachem S, Aguirre A, Vives V, Marks A, Gallo V, Legraverend C. (2005) Spatial and temporal expression of S100B in cells of oligodendrocyte lineage. Glia 51, 81-97.
Aguirre A and Gallo V. (2004) Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone. Journal of Neuroscience 24, 10530-10541.
Chittajallu R, Aguirre A*, Gallo V. (2004) NG2-positive cells in the white and grey matter display distinct physiological properties. Journal of Physiology 561,109-122. *Equal first authorship.
Aguirre A, Chittalallu R, Belachew S and Gallo V. (2004) NG2-expressing cells in the subventricular zone are Type C-like cells and contribute to interneuron generation in the postnatal hippocampus. Journal of Cell Biology 165, 575-589.
López-Bayghen E, Aguirre A, and Ortega A. (2003) Transcriptional regulation through glutamate receptors: involvent of tyrosine kinases. Journal of Neuroscience Research 74, 717-725.
Belachew S, Chittalallu R, Aguirre A, Yuan X, Anderson S, Kirby M, and Gallo V. (2003) Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. Journal of Cell Biology 161, 169-186.
Belachew S, Aguirre A, Wang H, Vautier F, Yuan X, Anderson S, Kirby M, and Gallo V. (2002) Cyclin-Dependent kinase 2 controls oligodendrocyte progenitor cell cylce progression and is downregulated in adult oligodendrocyte progenitors. Journal of Neuroscience 22, 8553-8562.
Aguirre A, López-Bayghen E, and Ortega A. (2002) Glutamate-dependent transcriptional regulation of the chkbp gene: Signaling mechanims. Journal of Neuroscience Research 70, 117-127.
Aguirre A, López T, López-Bayghen E, and Arturo Ortega. (2000) Glutamate regulate kainate binding protein expression in cultured chick Bergmann glia through Activator-Protein-1. Journal of Biological Chemistry 275 39246-39253.

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