Source: http://www.biotech-asia.org/vol15no3/biodegradable-polycaprolactone-nanoparticles-based-drug-delivery-systems-a-short-review/
Timestamp: 2019-04-19 12:37:56+00:00

Document:
Ramanujamv R, Sundaram B, Janarthanan G, Devendran E, Venkadasalam M, Milton M. C. J. Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review. Biosci Biotech Res Asia 2018;15(3).
1Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India.
2Department of Biotechnology, Annai College of Arts and Science, Kumbakonam, Tamil Nadu, India.
ABSTRACT: Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.
Figure 1: Chemical structure of polycaprolactone.
Figure 2: Illustration of polycaprolactone nanoparticles preparation by nanoprecipitation method.
Table 1: List of few various aqueous solution of surfactants used for polycaprolactone nanoparticles preparation.
Table 2: List of few drugs/bioactive molecules have been loaded into polycaprolactone nanoparticles.
Nanoparticles based drug delivery systems are showing greater potential in improving the pharmacological and therapeutic potential of various bioactive molecules. The encapsulation of drugs/bioactive molecules into nanoparticles protects degradation of the drugs/bioactive molecules and also supports controlled release for targeted drug delivery. In addition, it minimizes the toxicity and other adverse effects in normal tissues. Polycaprolactone, synthetic biodegradable polymer has studied extensively in different formulations as a carrier for various drug delivery applications. Here, this short review focused primarily on the recent approaches in various drugs/bioactive molecules loaded polycaprolactone nanoparticles using nanoprecipitation method. In future perspective, encapsulation of various drugs/bioactive molecules into polycaprolactone based nanoparticles facilitates sustained and targeted delivery in various drug delivery and biomedical applications for an effective therapeutic potential.
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