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John Brown was a Lecturer in Organic Chemistry between 1974 and 2008 following an earlier post at the (brand new) University of Warwick between 1966 and 1974. He was and is a Fellow of Wadham College, now Emeritus. After retirement he held a Leverhulme Emeritus Fellowship for two years and with the initial help from this source continues to be research active through current collaborations, and involvement in non-experimental approaches. He does not recruit students now and does not have his own research space, but would welcome interest from like-minded chemists.
His main long term involvement has been in the catalysis of organic reactions, especially for enantioselective synthesis. He played a part in the emerging area of rhodium asymmetric hydrogenation, helping to unravel the mechanism through the characterization of reactive intermediates (sometimes called the Halpern-Brown mechanism), and contributing to substituent stereocontrol in directed hydrogenations where a stereocentre in the reactant controls the diastereoselection at a new one generated in the reductive step. This led naturally to work on asymmetric hydroboration, and by good fortune the ligand Quinap, designed and synthesized in the research group, proved very effective for this reaction. More recent ventures in catalysis include various studies of palladium catalysed coupling of alkenes (the Heck reaction) including asymmetric couplings, the ruthenium-catalysed reaction, C-H activation studies in arenes and heteroarenes, and perhaps the favourite - the observation of Pd-catalysed methylation of methylation via in internally activated TMS group. The mechanism of Soai's amplifying asymmetric autocatalysis and the structure of the reactive intermediates has been an enduring interest. Much of the emphasis in mechanistic work has been on NMR, as a characterization technique, for the identification of transient intermediates, and in studies of turnover.
Asymmetric catalysis has produced a vast literature and an amazing range of successes. Inevitably, the detailed understanding has lagged behind to a degree, and many groups are now making good the deficit. His work involves both computation and analysis. High level computational methods are routinely accessible now, and can be used by the non-professional. The emphasis is directed towards the ways in which ligand variation can make profound differences to the level of efficiency of catalysis and their role in the underlying recognition processes. A range of simple processes - for example reactions at the borderline of concertedness - are being addressed. The CDS crystallographic database is a superb resource for addressing the relationship between catalyst structure, selectivity and reactivity.
The Metal-Ammonia Reduction of an Allene, J.M. Brown, Chem. and Ind., 1963, 1689.
Hydroaromatic Steroid Hormones (X).Conversion of Oestrone into Androst-4-ene-3,17-dione, A.J.
Birch, J.M. Brown and G.S.R. Subba Rao, J. Chem., Soc., 1964, 3309.
J.M. Brown and F. Stansfield, J. Chem. Soc., 1964, 5343.
Antiaromaticity of Cyclopropenyl Anions, R. Breslow, J.M. Brown and J.J. Gajewski, J. Amer.
Chem. Soc., 1967, 89, 4383.
Extensive Delocalisation in Potassium Bicyclo[3.2.1]octadienylide J.M. Brown, J.Chem. Soc.
J.M. Brown and J.L. Occolowitz. J. Chem. Soc., (B) 1968, 411.
Addition of Deuterium Chloride to Norbornene and Norticyclene; a 220 MHz N.m.r. study, J.M.
Brown and M.C. McIvor, Chem. Commun., 1969, 238.
Olefin, J.M. Brown, J. Chem. Soc.(B) 1969, 868.
Carbanions and Electrophilic Substitution, J.M. Brown "Organic Reaction Mechanisms, 1968", B.
[4.2.1.02,5]nona-3,7-diene and exo- and endo -Tricyclo[4.2.1.02,5]non-3-ene, H.M. Frey, J.
Metcalfe and J.M. Brown, J. Chem. Soc., (B) 1970, 1586.
J. Amer. Chem. Soc., 1970, 92, 3821.
Carbanions and Electrophilic Substitution, J.M. Brown "Organic Reaction Mechanisms, 1969; B.
an Allylic Anion, J.M. Brown, E.N. Cain and M.C. McIvor, J. Chem. Soc., B, 1971, 730.
Carbonium Ion and Carbene Intermediates J.M. Brown and B.D. Place J.Chem. Soc.Chem.
Solution, J.M. Brown, B.T. Golding and M.J. Smith, J. Chem. Soc.Chem. Commun., 1971, 1240.
K.R. Aris, V. Aris and J.M. Brown, J. Organometal Chem., 1972, 42, C67.
J. Chem. Soc.Chem. Commun., 1972, 1206.
Incipient Chirality in Organometallic Triphenylphosphine Complexes, J.M. Brown and K. Mertis, J.
Organometal Chem., 1973, 47, C5.
Isolation and Characterisation of cis--Divinylcyclopropane J.M Brown, B.T. Golding and J.J.
Stofko, Jr., J. Chem. Soc.Chem. Commun., 1973, 319.
30. Cycloheptatrienerhodium (I) acetylacetonate, J.M. Brown and D.G. Coles, J. Organometal.
[6.1.0]nonatriene, J.M. Brown and M.M. Ogilvy J. Amer. Chem. Soc., 1974, 96, 292.
Complexes, V. Aris, J.M. Brown and B.T. Golding J. Chem. Soc. Perkin II, 1974, 700.
J.M. Brown and K.A. Taylor, J. Chem. Soc. Dalton, 1974, 2222.
Stereoselective Micelle-Promoted Ester Hydrolysis, J.M.Brown and C.A. Bunton, J. Chem.
C.A. Bunton and S. Diaz, J. Chem. Soc.Chem. Commun., 1974, 971.
J.M. Brown, J.A. Conneely, B.T. Golding and D.H. Williamson, J. Chem. Soc. Perkin II, 1975, 4.
J.A. Conneely and J.J. Stofko, Jr. J. Chem. Soc.Chem. Commun., 1975, 234.
Functional Surfactants in Aqueous Solution, J.M. Brown and J.D. Schofield, J. Chem. Soc.Chem.
rhodium Tetramer, N.W. Alcock, J.M. Brown, J.A. Conneely and D.H. Williamson, J. Chem. Soc.
Surfactants, J.M. Brown and J.A. Jenkins, J. Chem. Soc.Chem. Commun., 1976, 456.
dihydrosqualene, J.M. Brown and D.R.M. Martens, Tetrahedron, 1977, 33, 931.
and trans- 1,5-Bis (diphenylphosphino)-3-oxapentane-P,P' carbonyl chlororhodium(I) Dimer, N.W.
Alcock, J.M. Brown and J.C. Jeffery, J. Chem. Soc. Dalton 1977, 888.
Strong Amide-Halothane Hydrogen-bonding observed by Nuclear Magnetic Resonance, J.M.
Brown and P.A. Chaloner, Canad. J. Chem., 1977, 55, 3380.
Perspectives in Organic Chemistry", 1978, 149.
(diphenylphosphinomethyl)-2,2-dimethyldioxolan (DIOP) Complexes. J.M. Brown and P.A.
Chaloner, J. Chem. Soc.Chem. Commun., 1978, 321.
50. Mechanism of Asymmetric Hydrogenation Catalysed by Rhodium (I) DIPAMP complexes, J.M.
Brown and P.A. Chaloner, Tetrahedron Letters, 1978,19, 1877.
P.A. Chaloner, J. Amer. Chem. Soc.,1978, 100, 4307.
Acyl-transfer Reactions in Functional Micelles studied by Proton Magnetic Resonance, J.M.
Brown, P.A. Chaloner and A. Colens, J. Chem. Soc. Perkin II, 1979, 71.
Hydrophobic Effects in the Micellar Reactions of Peroxide Nucleophiles, J.M. Brown and J.R.
Darwent J. Chem. Soc.Chem. Commun., 1979, 169.
J.M. Brown and J.R. Darwent, J. Chem. Soc.Chem. Commun., 1979, 171.
Preparation of its Phosphine Analogue (DIOP). B.A. Murrer, J.M. Brown, P.A. Chaloner, P.N.
Nicholson and D. Parker, Synthesis, 1979, 350.
Further Studies on Metal-promoted Vinylcyclopropane to Cyclopentene Rearrangements.
Asymmetric Hydrogenation. J.M. Brown and B.A. Murrer, Tetrahedron Letters, 1979, 20, 485-9.
60. Structure and Reactivity in Micellar Aggregates, J.M. Brown, SPR Colloid Science, 1979, 3, 253.
of Enamides defined by 13C N.m.r. Spectroscopy, J.M. Brown and P.A. Chaloner, J. Chem. Soc.
dioxolan. A Stable Rhodium Dihydride derived from a Chelating Diphosphine Complex, J.M.
Supported Rhodium-phosphine Hydrogenation Catalysts of High Mobility and Reactivity, J. M.
Brown and H. Molinari, Tetrahedron Letters, 1979, 20, 2933.
ff, D.H.R. Barton and W.D. Ollis, Ed., Pergamon Press 1979.
J.M. Brown, P.A. Chaloner, R. Glaser and S. Geresh Tetrahedron, 1980, 36, 815.
D. Parker., A.C.S. Symposium Series, 1980, 119, 169.
diphenylphosphino)ethane' J.M. Brown and P.A. Chaloner, J. Am. Chem. Soc., 1980, 102, 3040.
Intermediates in the Asymmetric Hydrogenation of Unsaturated Carboxylic Acid Derivatives, J.M.
Brown and D. Parker, J.Chem.Soc. Chem. Commun., 1980, 342.
Dephosphorylation in Functional Micelles. The Role of the Imidazole Group, J.M. Brown, C.A.
Bunton, S. Diaz and Y. Ihara, J. Org. Chem., 1980, 45, 4169.
bis(diphenylphosphineomethyl)dioxolane, G. Descotes, D. Lafont, D. Sinou, J.M. Brown and P.A.
Chaloner, Nouv. J. Chem., 1981, 5, 167.
Tetrahedron Letters, 1981, 22, 2815.
from Rhodium Diphosphine Precursors. J.M. Brown, P.A. Chaloner, A.G. Kent, B.A. Murrer, P.N.
Nicholson. D. Parker and P.J. Sidebottom, J. Organometal Chem., 1981, 216, 263.
Structural Specificity in Asymmetric Charge-transfer Complexation of Helicenes, J.M. Brown, I.P.
Field and P.J. Sidebottom, Tetrahedron Letters, 1981, 22, 4867.
80. Selective Micellar Catalysis with Histidinyl Surfactants of Defined Absolute Configuration, J.M.
Brown, R.L. Elliott, C.G. Griggs, G. Helmchen and G. Nill, Angew. Chem. Int. Ed., 1981, 20, 890.
Mechanistic Studies of Rhodium-Catalysed Asymmetric Homogeneous Hydrogenation. J.M.
Brown, P.A. Chaloner and D. Parker, A.C.S. Advances in Chemistry Series, 1982, 196, 355.
Homoallylic Alcohols, J.M. Brown and R.G. Naik, J. Chem. Soc. Chem. Commun., 1982, 348.
and W.G. Richards, J. Chem. Soc. Perkin II, 1982, 485.
-a-phenylalkane Complexes in Catalytic and Structural Studies, J.M. Brown and B.A. Murrer, J.
Chem. Soc. Perkin II, 1982, 489.
Observation of Dicarbonyldiphosphinerhodium Hydrides and their Olefin Trapping Ability, J.M.
Brown, L.R. Canning, A.G. Kent and P.J.Sidebottom, J. Chem. Soc. Chem. Commun., 1982, 721.
J.M. Brown and A.G. Kent, J. Chem. Soc. Chem. Commun., 1982, 723.
Complexes, J.M. Brown, I. Midgley and W.J. Albery, J. Chem. Soc. Perkin II, 1982, 767.
Deuterium and Hydrogen Deuteride, J.M. Brown and D. Parker Organometallics, 1982, 1, 950.
Kinetic and Thermodynamic Control in the reaction of (Ph3P)2 PtO2 with E-2-Butenal, M.J.
Broadhurst, J.M. Brown and R.A. John, Angew. Chem. Int. Ed., 1983, 22, 47.
Interconversion of cis and trans-Dihydrides derived from Chelate Biphosphine Complexes, J.M.
Brown, F.M. Dayrit and D. Lightowler, J. Chem. Soc. Chem. Commun., 1983, 414.
Chelation, J.M. Brown and L.R. Canning, J. Chem. Soc. Chem. Commun., 1983, 460.
Asymmetric Hydrogenation Reactions using Chiral Diphosphine Complexes of Rhodium, J.M.
Brown and P.A. Chaloner, "Homogeneous Catalysis with Metal-Phosphine Complexes", L.H.
Pignolet, Ed. Plenum Press, 1984, pg 137 ff.
Test for the Reversibility of Hydrogen Addition, J.M. Brown, L.R. Canning, A.J. Downs and A.M.
Forster. J. Organometallic Chem., 1983, 255, 103.
and L.R. Canning, J. Organometal Chem., 1984, 267, 179.
A Simple Route to bb-Trehalose via Trichloroacetimidate Coupling, J.M. Brown, S.J. Cook and R.
Khan, J. Carbohyd. Chem., 1984, 3, 343.
dioxolanethyleneplatinum  under mild conditions, J.M. Brown, S.J. Cook and S.J. Kimber, J.
Organometal Chem., 1984, 269, C58.
Complexes towards Alkenes, J.M. Brown, L.R. Canning and A.R. Lucy, J. Chem. Soc. Chem.
ethane)hydridomethylplatinum with p-Chlorophenyl Isonitrile, N.W. Alcock, J.M. Brown and T.D.
McLean, J. Chem. Soc. Chem. Commun., 1984, 1689.
Observations on Olefin Oxidation by Neutral and Cationic Phosphineiridium Complexes, J.M.
Association of Alkali-metal Salts with Polyene Macrolides in Methanol Solution, J.M. Brown, A.E.
Derome and S.J. Kimber, Tetrahedron Letters, 1985,26, 253.
S.A. Hall, J. Organometal Chem., 1985, 285, 333.
Iridium Analogues of Catalytic Intermediates in Asymmetric Hydrogenation, N.W. Alcock, J.M.
Brown, A.E. Derome and A.R. Lucy, J. Chem. Soc. Chem. Commun., 1985, 575.
J.M. Brown and I. Cutting, J. Chem. Soc. Chem. Commun., 1985, 578.
the Overall Stereoselectivity, J.M. Brown and J.E. MacIntyre J. Chem. Soc. Perkin II, 1985, 961.
External and Internal Asymmetric Induction in Homogeneous Hydrogenation, J.M. Brown, S.A.
Hydrogenation, J.M. Brown and S.A. Hall, Tetrahedron, 1985, 41, 4639.
Alcohols, J.M. Brown, A.E. Derome and S.A. Hall, Tetrahedron, 1985, 41, 4647.
Stereoselectivity in the Hydroboration of Chiral Cyclohexane-derived allylic alcohols, D.H.
Birtwistle, J.M. Brown and M.W. Foxton, Tetrahedron Letters, 1986, 27, 4367.
Methanesulphonyl)Glucopyranose, and its bb-isomer. J.M. Brown, S.J. Cook, R.H. Jones and R.
Khan, Tetrahedron, 1986, 42, 5089.
Flexible Cis- or Trans- Chelating Biphosphine Ligands Derived from aa- or bb-Trehalose J.M.
Brown, S.J. Cook and A.G. Kent, Tetrahedron, 1986, 42, 5097.
TREDIP; A Highly Regioselective Route To a-Methylarylpropionaldehydes, J. M. Brown, S. J.
Cook, and R. Khan, Tetrahedron, 1986, 42, 5105.
A.P. James, J. Chem. Soc. Chem. Commun., 1987, 181.
Chiral Ligands for Organometallic Catalysis containing two Dioxolane Rings, J.M. Brown, F.M.
Dayrit and D. Sinou, J. Chem. Soc. Perkin II, 1987, 92.
Directed Homogeneous Hydrogenation, J.M. Brown, Angew. Chem. Int. Ed., 1987, 26, 190.
G.A. Morris, J. Chem. Soc. Perkin II, 1987, 1583.
employing N.m.r. Magnetisation Transfer, J.M. Brown, P.L. Evans and A.R. Lucy, J. Chem. Soc.
and Interconversion Pathways, J.M.Brown and A.G.Kent, J. Chem. Soc. Perkin II 1987, 1597.
and P.J. Maddox, J. Chem. Soc., Chem. Commun., 1987, 1276.
and P.J. Maddox, J. Chem. Soc., Chem. Commun., 1987, 1278.
Acyclic Systems, J.M. Brown, I. Cutting and A.P. James, Bull. Soc. Chim.France, 1988, 211.
Structure and Reactivity in Asymmetric Hydrogenation; A Molecular Graphics Analysis, J.M.
Brown and P.L. Evans, Tetrahedron, 1988, 44, 4905.
N.A. Cooley, Chem. Rev., 1988, 88, 1031.
Phil. Trans. R. Soc. Lond. A. 1988, 326, 587.
Catalytic Kinetic Resolution, J.M. Brown, Chem. and Ind., 1988, 612.
tetrafluoro borate, and Asymmetric Analogues, N.W. Alcock, J.M. Brown and P.L. Evans, J.
iridium (I) tetrafluoroborate, J.M. Brown, P.L. Evans, P.J. Maddox and K.H. Sutton, J. Organomet.
Reactions, J.M. Brown and N.A. Cooley, J. Chem. Soc. Chem. Commun., 1988, 1345.
J. Organomet. Chem.,1989, 361, 249.
Structure of the Rhodium Complex of a Reactant in Directed Hydrogenation, N.W. Alcock, J.M.
Brown and A.P. James, Acta Cryst. C, 1989, 45, 734.
Diastereoselectivity in the Intramolecular Diels-Alder Reaction of Dienylpropynoates, D.H.
Birtwistle, J.M. Brown, and M.W. Foxton, Tetrahedron, 1988, 44, 7309.
D.W. Price, J. Chem. Soc. Chem. Commun., 1989, 458.
A.J. Pratt, and G.W.J. Fleet, Chemistry in Britain 1989, 259.
Asymmetric Homogeneous Catalysis, J.M. Brown, Chemistry in Britain, 1989, 276.
On the Strain Energies of 5-Ring and 6-Ring Lactones, J.M. Brown, A.D. Conn, G. Pilcher, M.L.P.
Leitao and Y. Meng-Yann, J. Chem. Soc. Chem. Commun., 1989, 1817.
and N.A. Cooley, Organometallics, 1990, 9, 353.
Tetrahedron Asymmetry, 1990, 1, 869.
G. Pilcher, M-Y Yang, J.M. Brown and A.D. Conn, J. Chem. Therm., 1990, 22, 885.
K.V. Baker, J. M. Brown, N. Hughes, A.J. Skarnulis and A. Sexton J. Org. Chem, 1991, 56, 698.
Control Factors for Selective Homogeneous Catalysis, J.M. Brown, J.V. Carey, A.D. Conn, G.C.
The Carbon-Carbon Bond forming Step in Catalytic Cross-coupling; Migration or Elimination? M.J.
A Simple General Route to Chelate Diphosphine Ruthenium (II) Complexes, N.W. Alcock, J.M.
Brown, M. Rose and A. Wienand, Tetrahedron Asymmetry, 1991, 2, 47.
Formates Catalysed by Novel Ruthenium Phosphine Complexes, J.M. Brown, H. Brunner, W.
Leitner and M. Rose Tetrahedron Asymmetry, 1991, 2, 331.
1991, 3, 345 [ s.a.1992, 4, 71]. (P.Pino memorial volume).
J. Chem. Soc. Perkin II, 1991, 2081.
the Reduction of a-Pinene, J.M. Brown, A.E. Derome, G.D. Hughes and P.K. Monaghan, Aust J.
Chem 1992, 45, 143 (A.J. Birch 75th Birthday issue).
Synthesis and Racemisation of an Atropisomerically Chiral Phosphinamine, N.W. Alcock, J.M.
Brown, M. Pearson and S. Woodward,Tetrahedron :Asymmetry 1992, 3, 17.
Restricted Rotation in cis-Diphosphine Arylplatinum Complexes, N.W. Alcock, J.M. Brown and J.J.
Tetrahedron :Asymmetry, 1992, 3, 261.
Catalysis, J. M. Brown and G.C. Lloyd-Jones, J. Chem. Soc. Chem. Commun., 1992, 710.
Intramolecular Facilitation of Aryl-transfer from Tin in Palladium-catalysed Cross-coupling, J. M.
Brown, M. Pearson, J.T.B.M. Jastrzebski and G. Van Koten , J. Chem. Soc Chem. Commun.
Reviews, 1993, 22, 25 [Tilden Lecture].
using Oxazaphospholidines, J.V. Carey, M.D. Barker, J.M. Brown and M.J.H. Russell, J. Chem.
Soc. Perkin 1, 1993, 748-57.
J. Chem. Soc. Chem. Commun., 1993, 1512.
Origins of Enantioselectivity in Catalytic Asymmetric Synthesis, J.M. Brown, P.J. Guiry and A.
Chapman and Hall, 1993, Ch 4, pp. 79-108.
Reversible Monomer-Dimer Equilibria in an Ephedrine-derived Oxazaborolidine, J.M. Brown, G.J.
Diphenylphosphino-1'-naphthyl)isoquinoline, J.M. Brown, D.I. Hulmes and T.P. Layzell, J. Chem.
Soc. Chem. Commun., 1993, 1673-4.
Borane Structure and Relationship to Silation, J.M. Brown and G.C. Lloyd-Jones, J. Am. Chem.
V. C.M. Smith, R.T. Aplin, J.M. Brown, M.B. Hursthouse, A. I. Karalov and N.A. Cooley, J. Am.
Chem. Soc., 1994, 116, 5180-9.
1994, 49, 4493-4506 (Sharpless / Noyori Tetrahedron Prize Invitation Issue).
Ethene Rhodium bis-Oxazolinylmethane Complexes, J.M. Brown, P.J. Guiry, D.W. Price, M. B.
Hursthouse and A. I. Karaulov, Tetrahedron : Asymmetry, 1994, 5, 561-4.
J. M. Brown J. J. Pérez-Torrente and N.W. Alcock, Organometallics, 1995, 14, 1195-1203.
J. Chem. Soc. Chem. Commun., 1995, 395-7.
Additives"; Thieme Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 1119-27.
Steric and Electronic Requirements of Amide and Ester Groups in Benzylidenemalonates J. M.
1995, 114, 242-51, (Chirality Special Issue).
Catalysts for Stereospecific Synthesis, J. M. Brown, "Speciality Inorganic Chemicals" Ch. 6., pg.
123-144, D. T. Thompson, Ed., RSC Publications, Cambridge, 1995.
Organic Compounds , J.M. Brown, Chapter 2.5.1.1.1. "Directed Homogeneous Hydrogenation";.
Thieme Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 4317-34.
Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 4360-4.
Tetrahedron : Asymmetry, 1995, 7, 2593-6.
naphthyl)phenanthridine, J-M. Valk, T. D. W. Claridge, J. M. Brown, D. Hibbs and M. B.
Hursthouse, Tetrahedron : Asymmetry, 1995, 7, 2597-2610.
Organometallic Chemistry" 2nd. Ed., A. McKillop, Ed., Volume 11, 1995, pg. 129-158.
(2-methoxyphenyl)-P-phenyl-P-(2'-diphenylphosphino)ethylphosphine, J. A. Ramsden, T. D. W.
(The Heck Reaction), J.M. Brown and K. K. (Mimi) Hii, Angew. Chem. Int Ed. Engl.
Tetrahedron : Asymmetry, 1996, 7, 285-92.
Supports for Solid Phase Synthesis with High Fluidity and High Functionality, J. M. Brown and J.
Catalytic Asymmetric Hydroboration-Amination E. Fernandez, M. W. Hooper, F. I. Knight and J. M.
giving Insights into Catalytic Asymmetric Allylation, T. D. W. Claridge, J. M. Long, J. M.Brown, D.
Conformational Analysis of Phosphinamine Ligands, J. M. Brown, D.I.Hulmes, J.M. Long, J-M.
Conference on Trends in Organometallic Chemistry, 1997, 28.
Encumbered Groups, J. M. Brown and J.C.P. Laing, J. Organometal Chem., 1997, 529, 435-44.
Intermediates in the Intermolecular Asymmetric Heck Arylation of Dihydrofurans, K. K. Hii, T. D.
W. Claridge and J. M. Brown, Angew. Chem. Int. Ed., 1997, 36, 984-7..
134, 499-510 (Kagan Special Issue).
H.Doucet and J. M. Brown, Tetrahedron : Asymmetry, 1997, 8, 3775-84.
R. T. Aplin, H. Doucet, M. W. Hooper and J. M. Brown, Chem. Commun., 1997, 2097-8.
Diastereoselective Homogeneous Hydrogenations Without Direction by Substituents, E.
The Heck Olefination Reaction; A DFT Study of the Elimination Pathway, R. J. Deeth, A. Smith, K.
Allylic Alkylation with Function-bearing Organozinc Reagents, H. Doucet and J. M. Brown, Bull.
Soc. Chim. France, 1997, 134, 995.
Rational Models for the Carbonyl-ene Cyclization Reaction. Open and Closed Transition-states, D.
Mechanism and Synthesis in Catalytic Hydroboration, J.M. Brown, H. Doucet, E. Fernandez, H.E.
Catalysis” Vol 1, Springer-Verlag, Heidelberg, 1999, 60-122.
Phosphine-boranes and Aryl Iodides, A.C. Gaumont, M. B. Hursthouse, S. J. Coles, and J. M.
Brown, Chem. Commun, 1999, 63-4.
J. M. Brown, Chem. Commun., 1999, 261-2.
Chemistry; Eur. J., 1999, 5, 1320-30.
Topics in Organometallic Chemistry, (Preface VII-XIV) Vol 4.Springer-Verlag, Heidelberg, 1999.
Diastereoselectivity in Scalemic Tartrate /Titanium Epoxidations, J. M. Brown, S. J. Leppard, J.
1,1'-(2-Diarylphosphino-1-naphthyl)isoquinoline, E. Fernandez, K. Maeda, M. W. Hooper and J. M.
Brown, Chemistry; Eur. J., 2000, 6, 1840-1846.
methods" Ch 2., A. Ricci, Ed., Wiley-VCH, 2000, Chapter 2, pages 37-63.
and J. M. Brown, Coll Czech. Chem. Comm., 2000, 65, 741-756(Cervinka Invitation Issue).
Hydrogenation of Dehydroamino Acids, R. Giernoth, H. Heinrich, N. J. Adams, R. J. Deeth, J.
New Mechanistic Aspects of the Asymmetric Homogeneous Hydrogenation of Alkenes, J. M.
Resolution and Coupling of 1-2ʼ-Hydroxy-1ʼ-naphthyl)isoquinolines, S. C. Tucker, J. M. Brown, J.
Interplay of Synthesis and Mechanism in Asymmetric Homogeneous Catalysis, N. J. Adams, J.
Bargon, J. M. Brown, E. J. Farrington, E. Galardon, R. Giernoth, H. Heinrich, B. D. John, K.
Scope and Limitations of Ruthenium-catalysed Metathesis of Simple Polymer-bound Alkenes, P.
G. Breed, J. A. Ramsden and J. M. Brown, Can J. Chem, 2001, 79, 1049-1057.
H. Heinrich, J. Bargon, R. Giernoth, J. M. Brown, Chem. Commun. 2001, 1296-1297.
Origins of Asymmetric Amplification in Autocatalytic Alkylzinc Additions, D. G. Blackmond, C. R.
Viviente, B. S. Williams, G. van Koten and J. M. Brown, Chem. Commun, 2002, 308-309.
Nobel Prizes in Chemistry 2001; Asymmetric Hydrogenation recognised! J. M. Brown, Adv. Synth.
Efficient Kinetic Resolution in Hydroboration of 1,2-Dihydronaphthalenes. K. Maeda and J. M.
Ruthenium-catalysed Oxidative Heck Reactions, J. M. Brown, E. J. Farrington, C. F. J. Barnard, E.
Complexes. E. Galardon, S. Ramdeehul, J. M. Brown, A. R. Cowley, K. K. (Mimi) Hii and A.
Jutand, Angew. Chem. Int. Ed., 2002, 41, 1760-1763.
Palladium Catalysts in the Suzuki Reaction, R. B. Bedford, S. L. Hazelwood, M. E. Limmert, J. M.
J. M. Brown, Org. Biomol. Chem., 2003, 1, 3811-3819.
A Direct meta-Lithiation Route to 1,3-Disubstituted Ferrocenes, C. Pichon, B. Odell and J. M.
Brown, Chem. Commun., 2004, 598-9.
J. M. Brown, Proc. Natl. Acad US, 2004, 101, 5727-5731.
Vinylarenes, K. K. (Mimi) Hii, T. D. W. Claridge, R. Giernoth and J. M. Brown, Adv. Syn. Catal.
Mechanism in Homogeneous Catalysis; NMR as a Prime Mover. J. M. Brown, J. Organomet.
Halide Tolerance, E. J. Farrington, C. F. J. Barnard, E. Rowsell and J. M. Brown, Adv. Syn. Catal.
Cryst. E, 2005, 61, m585- m586.
S. J. Roseblade, A. R. Cowley, R. Fernandez, J. M. Brown, and J. M. Lassaletta, J. Am. Chem.
260 Directed palladation: fine tuning permits the catalytic 2-alkenylation of indoles, E. Capito, J.
M. Brown and A. Ricci, Chem. Commun. 2005, 1746-1748.
and –ferrocenes, D. Carmichael, L. Ricard, N. Seeboth, J. M. Brown, T. D. W. Claridge, B.
J. M. Brown, and C. Pichon, Chem. Commun. 2005, 5284-5286.
P)palladium (II), G. Espino, J. M. Brown and A. R. Cowley, Acta Cryst. 2007, E63, m2047-m2048.
Role of the isopropyl group in asymmetric autocatalytic zinc alkylations, J. Klankermayer, I. D.
Gridnev, J. M. Brown, Chem. Commun. 2007, 3151-3153.
The Guareschi Reaction (1897). Alkyl Radical Generation in Water under Ambient Conditions, B.
Nguyen, J. M. Brown, K. Chernous, D. Endlar, B. M. Odell, M. Piacenti, A. S. Dorofeev and A. V.
Burasov. Angew. Chem. Int. Ed., 2007, 46, 7655-7658.
A Protocol for the Direct Conversion of Aldehydes to Arenes; Proof of Principle, M. Gayral and J.
M. Brown, Synlett, 2007, 2823-2826.
D. M. P. Mingos and J M. Brown, Chem Commun, 2008, 199-201.
Asymmetric Autocatalysis with Organozinc Complexes; Elucidation of the Reaction Pathway, I.
D.Gridnev, J. Klankermayer, J. M. Brown, Topics Current Chem., 2008, 284, 35-65; K. Soai, Ed.
Sequential ortho-Lithiations; the Sulfoxide group as a Relay to enable meta-Substitution, J. P.
Flemming, M. B. Berry and J. M. Brown, Org. Biomol. Chem., 2008, 1215-1221.
Coupling, W. Rauf and J. M. Brown, Angew. Chem. Int. Ed., 2008, 47, 4228-4230.
S. Gosiewska, B. Nguyen, J. M. Brown, Chem. Commun., 2008, 5092-5094.
Tetrameric Iridium Hydride-rich Clusters formed under Hydrogenation Conditions, Y. Xu, M. A.
Celik, A. L. Thompson, H. Cai, M. Yurtsever, B. Odell, J. C. Green, D. M. P. Mingos, and J. M.
Brown, Angew. Chem. Int. Ed., 2009, 48, 582-5.
Allylic Fluorides are Responsive to Palladium-catalysed Substitution, A. Hazari, V. Gouverneur, J.
M. Brown, Angew. Chem. Int. Ed., 2009, 48, 1296-1299.
Stereoselectivity in the Rhodium-catalysed Reductions of Non-conjugated Dienes, B. Nguyen, J.
M. Brown, Adv. Syn. Catal. 2009, 351, 1333-1343.
M. Gayral, Y. Xu and M. I. Stewart, Synlett, 2009, 1387-1390.
Angew. Chem. Int. Ed., 2009, 48, 4476-4479.
Amide Groups, W. Rauf, A.L. Thompson and J. M. Brown, Chem. Commun. 2009, 3874-3876.
and V.Gouverneur, Angew. Chem. Int. Ed., 2009, 48, 8610-8614.
Observation of 2,7-Disubstitution in Palladium-catalysed Directed C-H Activation of Indoles, G.
Catalytic activation of hydrogen, silicon and fluorine by transition-metal complexes, W. Rauf, A.
Hazari, V. Gouverneur and J. M. Brown, Pure. Appl. Chem. 2010, 82,1415-1428.
J. A. Raskatov, A. L. Thompson and J. M. Brown, Tetrahedron: Asymmetry, 2010, 21, 1734-1740.
Pyrimidyl Aldehydes, M. Quaranta, T. Gehring, B. Odell, J. M Brown, and D. G. Blackmond, J.
Amer. Chem. Soc., 2010, 132, 15104-15107.
W. Rauf, A. L. Thompson and J. M. Brown, Dalton Trans., 2010, 39,10414-10421. .
Hydroboration and Diboration of Alkenes, Stereoselective Synthesis 1.7 Science of Synthesis, B.
N. Nguyen and J. M. Brown, Thieme; 2010 pg 295-324.
Angew. Chem.-Int. Ed., 2011, 50, 2613-2617.
Chiral selection in the formation of borates from racemic binaphthols and related diols J. A. Raskatov, J. M. Brown, and A. L. Thompson, Crystengcomm, 2011, 13, 2923-2929.
Electrophilic Routes to Tertiary Adamantyl and Diamantyl Phosphonium salts, J. Prabagar, A. R.
Cowley and J. M. Brown, Synlett, 2011, 2351-2354 (A. Ricci Special Issue).
The Origins of Enantioselectivity in Rh-diene Complex Catalysed Arylation of Cyclohex-2-enones.
S. Gosiewska, J. A. Raskatov, R. Shintani, T. Hayashi, J. M. Brown, Chem.- Eur. J., 2012, 18, 80-84.
C.Hollingworth, J. M. Brown and V. Gouverneur, Organometallics, 2012, 31, 1408-1416.
Palladium-Catalyzed Substitution and Cross-Coupling of Benzylic Fluorides, G. Blessley, P.
Holden, M. Walker, J. M. Brown and V. Gouverneur, Org. Lett., 2012, 11, 2754-2757.
Dinuclear Palladium Complexes – Precursors or Catalysts? R. S. Paton and J. M. Brown, Angew.
Chem.-Int. Ed., 2012, 51, 10448-10450.
from 1H NMR Turnover in Real Time, T. Gehring, M. Quaranta, B. Odell, D. G. Blackmond and J.
M. Brown, Angew. Chem.-Int. Ed., 2012, 51, 9539-9542.
Carbonates under Ir-Catalysis, E.Benedetto, M. Tredwell, C. Hollingworth, T. Khotavivattana, J. M. Brown and V. GouverneurChem. Sci. 2013, 4, 89-96.
[(diphenylphosphino)naphthyl]isoquinoline complex catalysts”, J. M. Brown,. PCT Int. Appl.
(1995), 37 pp. WO 9513284.
Preparation of diphosphines as cocatalysts for asymmetric hydrogenation. J. M. Brown; D.
Carmichael; H. Doucet, PCT Int. Appl. (2000), WO 2000026220, 21 pp.
dienes, J. M. Brown, M. Mayr; UK Patent Application (2006).

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