Source: http://www.lza.lv/scientists/kaussv.htm
Timestamp: 2019-04-23 06:56:16+00:00

Document:
Development of new modulators of ionotropic and metabotropic glutamate receptors.
Stereoselective synthesis of aminocycloalkanes and nitrogen heterocycles.
Aminoalkane sp3 CH functionalization reactions.
The Latvian State University, Faculty of Chemistry. Riga, Latvia, 1977.
The Addition Reaction of Thiosemicarbazides to Acetylenecarboxylic Acids and their Esters Supervisor: Professor I. Kalvinsh.
Testimonial writing from Prime Minister of the Latvian Republic For contribution in the development of medicinal chemistry and preparing of new specialists, February 2007.
Award of academician Solomon Hiller, 2006.
Member of Scientific Council, Latvian Institute of Organic Synthesis.
T.Noeske, D.Trifanova, V.Kauss, S.Renner, C.G.Parsons, G.Schneider, T.Weil. Synergism of virtual screening and medicinal chemistry: Identification of allosteric antagonists of metabotropic glutamate receptor 1. - Bioorg.Med.Chem, 2009, 17 (15), 5708-5715.
M. Vanejevs, C. Jatzke, S. Renner, S. Müller , M. Hechenberger, T. Bauer, A. Klochkova, I. Pyatkin , D. Kazyulkin , E. Aksenova , S. Shulepin, O. Timonina, A. Haasis, A. Gutcaits, C. G. Parsons, M. Henrich, V. Kauss, T.Weil. Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors .- J. Med. Chem.,2008, 51 (3), 634-647.
K. Gilling, C. Jatzke, C. Wollenburg, M. Vanejevs, V. Kauss, A. Jirgensons, C. G. Parsons. A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists  in vitro characterization. J. Neural Transm. 2007, publ. online 31 August 2007.
M. Vanejevs, C. Jatzke, S. Renner, M. Hechenberger, T. Bauer, A. Klochkova, I. Pyatkin , D. Kazyulkin , E. Aksenova , S. Shulepin, O. Timonina, A. Gutcaits, M. Henrich, V. Kauss, C. G. Parsons, T. Weil. Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors. J. Med. Chem. 2007, publ. online October 2007.
T. Noeske, A. Jirgensons, I. Stachenkovs, S. Renner, I. Jaunzeme, D. Trifanova, M. Hechenberger, T. Bauer, V. Kauss, C. G. Parsons, G. Schneider, T. Weil. Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure-Activity Relationship Investigations for Coumarine Derivatives. ChemMedChem. 2007, publ. online 17 September 2007.
I. Jaunzeme, A. Jirgensons, V. Kauss and E. Liepins. Diastereoselectivity in the Overman rearrangement of O-cyclohexylideneethylimidates. Tetrahedron Lett. 2006, 3885-3887.
D. Trifanova, M. Trifonova, A. Jirgensons, V. Kauss, O. Pugovich, I. Kalvinsh and G. Quack. The synthesis of potential Neramexane metabolites: cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids. Tetrahedron Lett. 2004, 8145-8147.
W. Danysz, C.G. Parsons, A. Jirgensons, V. Kauss, J. Tillner. Amino-Alkyl-Cyclohexanes as a Novel Class of Uncompetitive NMDA Receptor Antagonists. Curr. Pharm. Design, 2002, 8, 835-843.
A. Jirgensons, V. Kauss, I. Kalvinsh, M. R. Gold, W. Danysz, C. G. Parsons, G. Quack. Synthesis and structure - affinity relationships of 1,3,5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site. Eur. J. Med. Chem., 2000, 35, 555-565.
A. Jirgensons, V. Kauss, I. Kalvinsh, M. R. Gold. A practical synthesis of tert-carbinamines via the Ritter reaction with chloroacetonitrile. Synthesis, 2000, 1709-1712.
I. Starchenkov, P. Trapencieris, V. Kauss, G. Jas, I. Kalvinsh. A convenient synthesis of 5b -cholestan-26-oic and 5b -cholestan-26,27-dioic acids. Steroids, 2000, 65, 143-147.
A. Jirgensons, V. Kauss, A. F. Mishnev, I. Kalvinsh. The synthesis of 3-amino-3-methylbicyclo[3.3.1]nonanes. Endo-selectivity in the Ritter reaction of 1,3,5,7a -tetramethylbicyclo[3.3.1]nonan-3-ol. J. Chem. Soc. PT 1, 1999, 3527-3530.
O. Pugovics, V. Kauss, I. Kalvinsh, M. R. Gold, G. Quack. Convenient synthesis of 2,6-di-tert-butyl-4-(5-(3-pyridyl)-4-oxapentyl)phenols and their thia analogues. J. Chem. Res. (M), 1998, 1885-1894.
O. Pugovics, V. Kauss, I. Kalvinsh, M. R. Gold. The synthesis of (3,5-di-tert-butyl-4-hydroxyphenyl)methyl-(3-pyridylalkyl)ethers via 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methyl pyridinium salts. Synth. Commun., 1998, 28, 2227-2236.
A. Jirgensons, I. Kums, V. Kauss, I. Kalvinsh. A convenient reagent for N-hydroxyguanylation. Synth. Commun., 1997, 27, 315-322.
P. Trapencieris, I. Kalvin, L. Kaulina, V. Kauss . Unnatural amino acids. 1. A facile synthesis of methyl ester of aziridine-2-carboxylic acid. Organic Process Research & Development, 1997, 1, 259-263.
WO 2009/09524. Pyrazolopyridines, a process for their preparation and their use as medicine/ Henrich M., Weil T., Mueller S., Nagel J., Gravius A., Kauss V., Zemribo R., Erdmane E.
US 2009/0227582. Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors / Kauss V., Jaunzeme I., Jirgensons A., Kalvinsh I., Vanejevs M., Henrich M., Danysz W., Jatzke C., Parsons Ch.G.R., Weil T.
WO 2008/035049. Adamantanyl-(cyclopropyl)-ketones as metabotropic glutamate receptor modulators / Parsons Ch.G.R., Kalvinsh I., Trifanova D., Jirgensons A., Kauss V., Danysz W., Henrich M .
WO 2007/023245. Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors / Parsons Ch.G.R., Jirgensons A., Jaunzeme I., Kalvinsh I., Henrich M., Vanejevs M., Weil T., Kauss V., Danysz W., Jatzke C.
WO 2007/023290. Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors / Parsons Ch.G.R., Jirgensons A., Jaunzeme I., Kalvinsh I., Henrich M., Vanejevs M., Weil T., Kauss V., Danysz W., Jatzke C.
WO 2007/023242. Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors / Parsons Ch.G.R., Jirgensons A., Jaunzeme I., Kalvinsh I., Henrich M., Vanejevs M., Weil T., Kauss V., Danysz W., Jatzke C.
WO 2007/045876. Chromenones and their use as modulators of metabotropic glutamate receptors / Parsons Ch.G.R., Jirgensons A., Trifanova D., Kalvinsh I., Starchenkovs I., Henrich M., Noeske T., Weil T., Kauss V., Danysz W.
WO 2006/037996. Novel cyclic and acyclic propenones for treating CNS disorders / Parsons Ch.G.R., Kalvinsh I., Kauss V., Trifanova D., Zemribo R., Danysz W., Henrich M., Weil T.
WO 2003/080046. Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3 and neuronal nicotinic receptor antagonists / Parsons Ch.G.R., Henrich M., Danysz W., Kalvinsh I., Kauss V., Jirgensons A., Gold M., Vanejevs M.
WO 2002/24186. 1-Amino-alkylcyclohexanes as trypanocidal agents / Kelly M., Kalvinsh I., Kauss V., Jirgensons A., Gold M.
WO 2001/32640. 1-Cyclic amino-alkylcyclohexane compounds, pharmaceutical compositions thereof, and their use as anticonvulsants./ Gold M., Danysz W., Parsons C. G. R., Kalvinsh I., Kauss V., Jirgensons A.
WO 99/01416. 1-Amino-alkylcyclohexane NMDA receptor antagonists./ Gold M., Danysz W., Parsons C. G. R., Kalvinsh I., Kauss V., Jirgensons A.

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