Source: http://brain.mpg.de/research/emeriti/prof-dr-med-heinrich-betz/publications.html?type=1
Timestamp: 2019-04-19 10:20:37+00:00

Document:
Papadopoulos, T, Rhee HJ, Subramanian D, Paraskevopoulou F, Mueller R, Schultz C, Brose N, Rhee JS, Betz, H. (2017). Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses. J. Biol. Chem. 292: 1160-1177.
Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D et al. (2017) Building Bridges through Science. Neuron 96, 730 - 735.
McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL. (2017) Glycine receptor alpha3 and alpha2 subunits mediate tonic and exogeneous agonist-induced currents in forebrain. Proc Natl Acad Sci USA 114:E7179-E7186.
Dlugaiczyk J, Hecker D, Neubert C, Buerbank S, Campanelli D, Becker CM, Betz H, Knipper M, Rüttiger L, Schick B. (2016) Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function. Hear Res. 337:25-34.
Mesic I, Madry C, Geider K, Bernhard M, Betz H, Laube B. (2016) The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors. Neuropharmacology 105:133-141.
Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R. (2016) Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors. Front Mol Neurosci. 9:75.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, Betz H. (2016) Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice. Mol. Cell. Neurosci. 72:101-113.
Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KR, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, König R, Wang ZQ, Bräuer R, Petersen I (2016) Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell Death Dis. 7:e2205.
Del Pino, I., Koch, D., Schemm, R., Qualmann, B., Betz, H., Paarmann, I. Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors. J Biol Chem. 289 (2014) 11396-409.
McCracken, L.M., Blednov, Y.A., Trudell, J.R., Benavidez, J.M., Betz, H., Harris, R.A. Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. J Pharmacol Exp Ther. 344(2) (2013) 489-500.
Vlachos, A., Reddy-Alla, S., Papadopoulos, T., Deller, T., Betz, H. Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses. Cereb Cortex. 23(11) (2013) 2700-11.
Rhee, J.S., Papadopoulos, T. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci USA 110 (2013) 20795-800.
Dutertre, S., Becker, C.M., Betz H.. Inhibitory glycine receptors: an update. J Biol Chem. 287 (2012) 40216-40223.
Dutertre, S., Drwal, M., Laube, B., Betz, H. Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist binding site. J Neurochem. 122 (2012) 38-47.
Kallenborn-Gerhardt, W., Lu ,R., Lorenz, J., Gao, W., Weiland, J., Del Turco, D., Deller, T., Laube, B., Betz, H., Geisslinger, G., Schmidtko, A.. Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2. Behav Brain Res. 226 (2012) 106-111.
Lall, D., Armbruster, A., Ruffert, K., Betz, H., Eulenburg, V. Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord. Biochem Biophys Res Commun. 423 (2012) 661-666.
Nobles RD, Zhang C, Müller U, Betz H, McCall MA. Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways. J Neurosci. 32 (2012) 3321-3332.
Weltzien F, Puller C, O'Sullivan GA, Paarmann I, Betz H. Distribution of the glycine receptor β-subunit in the mouse CNS as revealed by a novel monoclonal antibody. J Comp Neurol. 520 (2012) 3962-3981.
del Pino, I., Paarmann, I., Karas, M., Kilimann, M. and Betz, H. The trafficking proteins Vacuolar Protein Sorting subunit 35 and Neurobeachin interact with the glycine receptor β-subunit. Biochem. Biophys. Res. Comm. 412 (2011) 435-440.
Ruffert, K., Himmel, B., Lall, D., Bamann, C., Bamberg, E., Betz, H. and Eulenburg, V. Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2. Biochem. Biophys. Res. Commun. 410 (2011) 737-43.
Jedlicka, P., Hoon, M., Papadopoulos, T., Vlachos, A., Winkels, R., Pouopoulos, A., Betz, H., Deller, T., Brose, N., Varoqueaux, F. and Schwarzacher, S.W. Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb. Cortex. 21 (2011) 357-67.
Reining, S.C., Liesegang, A., Sorribas, V., Betz, H., Biber J., Murer H. and Hernando, N. Expression of renal and intestinal Na/Pi-cotransporter in the absence of GABARAP. Pflüger's Arch. Eur. J. Physiol. 460 (2010) 207-217.
Ishihara, N., Armsen, W., Papadopoulos, T., Zeilhofer, H.-U., Betz , H. and Eulenburg, V. Generation of a mouse-line allowing genetic manipulation of glycinergic neurons. Genesis 48 (2010) 437-445.
Madry, C., Betz, H., Geiger, J.R.P. and Laube, B. Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification. Frontiers in Neuroscience 3 (2010) 6 (doi:0.3389/fnmol.2010.00006).
Eulenburg, V., Retiounskaia, M., Papadopoulos, T., Gomeza, J. and Betz, H. Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice. Glia 58 (2010) 1066-1073.
Kubota, S., Alle, H., Betz, H. and Geiger, J. Presynaptic glycine receptors on hippocampal mossy fibers. Biochim. Biophys. Res. Comm. 393 (2010) 587-591.
Reddy-Alla, S., Schmitt, B., Birkenfeld, J., Eulenburg, V., Dutertre, S., Böhringer, C., Götz, M., Betz, H. and Papadopoulos, T. PH-domain driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering. Eur. J. Neurosci. 31 (2010) 1173-1184.
Bausen, M., Weltzien, F., Betz, H. and O'Sullivan, G.A Regulation of postsynaptic gephyrin scaffold stability by serine/threonine protein phosphatases. Mol. Cell. Neurosci. 44 (2010) 201-209.
Haeger, S., Kuzmin, D., Detro-Dassen, S., Lang, N., Kilb, M., Tsetlin, V., Betz, H., Laube, B. and Schmalzing, G. An intramembrane network determines pentameric assembly of glycine receptors. Nat. Struct. Mol. Biol. 17 (2010) 90-98.
Moritz, A., Scheschonka, A., Beckhaus, T., Karas, M. and Betz, H. Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B. Biochem. Biophys. Res. Comm. 287 (2009) 522-529.
Maksay, G., Laube, B., Schemm, R., Grudzinska, J., Drwal, M. and Betz, H. Different binding modes of tropeines mediating inhibition and potentiation of a1 glycine receptors. J. Neurochem. 109 (2009) 1725-1732.
O'Sullivan, G., Hofer, W. and Betz, H. Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice. Neurosci. Lett. 458 (2009) 106-110.
Poulopoulos, A., Aramuni, G., Meyer, G., Soykan, T., Hoon, M., Papadopoulos, T., Paarmann, I., Fuchs, C., Harvey, K., Jedlicka, P., Schwarzacher, S., Betz, H., Harvey, R.J., Brose, N., Zhang, W. and Varoqueaux, F Neuroligin 2 drives postsynaptic assembly at inhibitory synapses through gephyrin and collybistin. Neuron 63 (2009) 628-642.
Dutertre, S., Kuzmin, D., Laube, B. and Betz, H. Glycine receptors Handbook of Neurochemistry and Molecular Neurobiology, Neural Signal Mechanism Signaling molecules in neural function (Mikoshiba, K., ed.) Vol. 1b (2009) pp. 375-390 (Springer US).
Jedlicka, P., Papadopoulos, T., Deller, T., Betz, H. and Schwarzacher, S.W. Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Mol. Cell. Neurosci. 41 (2009) 94-100.
Reining, S.C., Gisler, S.M., Fuster, D., Moe, O.W., O'Sullivan, G.A., Betz, H., Biber, J., Murer, H. and Hernando, N. GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes. Am. J. Physiol. Renal. Physiol. 29 (2009) F1118-F1128.
Schumann, T., Grudzinska, J., Kuzmin, D., Betz, H. and Laube, B. Binding-site mutations in the a1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator. Neuropharmacology 56 (2009) 310-317.
Papadopoulos, T., Eulenburg, V., Reddy Alla, S., Mansuy, I.M., Li, Y. and Betz, H. Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus. Mol. Cell. Neurosci. 39 (2008) 161-169.
Madry, C., Betz, H., Geiger, J. R.P. and Laube, B. Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist. Proc. Natl. Acad. Sci. USA 105 (2008) 12563-12568.
Grudzinska, J., Schemm, R., Betz, H. and Laube, B. Mutations within the agonist-binding site convert the homomeric a1 glycine receptor into a Zn2-activated chloride channel. Channels 2 (2008) 13-18.
PKC-dependent auto-inhibition of glutamate release, spatial working-memory deficits and increased susceptibility to pentylenetetrazol. J. Neurosci. 28 (2008) 8604-8614.
Tang, Z., Hecker, C.M., Scheschonka, A. and Betz, H. Protein interactions in the sumoylation cascade: lessons from X-ray structures. FEBS J. 275 (2008) 3003-3015.
Zacchi, P., Dreosti, E., Visintin, M., Moretto-Zita, M., Marchionni, I., Cannastraci, I., Kasap, Z., Betz, H., Cattaneo, A. and Cherubini, E. Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering. J. Mol. Neurosci. 34 (2008) 141-148.
Bertaso, F., Zhang, C., Scheschonka, A., de Bock, F., Fontanaud, P., Marin, P., Huganir, R., Betz, H., Bockaert, J., Fagni, L. and Lerner-Natoli, M. PICK1 uncoupling from mGluR7a causes absence-like seizures. Nat. Neurosci. 11 (2008) 940-948.
Scheschonka, A., Findlow, S., Schemm, R., El Far, O., Caldwell, J.H., Crump, M.P., Holden-Dye, K., O'Connor, V., Betz, H. and Werner, J.M. Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A. J. Biol. Chem. 283 (2008) 5577-5588.
Caldwell, J.H., Herin, G.A., Nagel, G., Bamberg, E., Scheschonka, A. and Betz, H. Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of the metabotropic glutamate receptor mGluR7. J.Biol. Chem. 283 (2008) 24300-24307.
Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, U., Sitte, H., Betz, H. and Eulenburg, V. Glycine transporter dimers: Evidence for occurrence in the plasma membrane. J. Biol. Chem. 283 (2008) 10978-10991.
Weiss, J., O'Sullivan, G.A., Heinze, L., Chen, H.-C., Betz, H. and Wässle, H. Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice. Mol. Cell. Neurosci. 37 (2008) 40-55.
Madry, C., Mesic, I., Betz, H. and Laube, B. The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of NMDA receptors. Mol. Pharmacol. 72 (2007) 1-10.
Armsen, W., Himmel, B., Betz, H. and Eulenburg, V. The C-terminal PDZ-ligand motif of the neuronal glycine transporter 2 is required for efficient synaptic localization. Mol. Cell. Neurosci. 36 (2007) 369-380.
Papadopoulos, T., Korte, M., Eulenburg, V., Kubota, H., Retiounskaia, M., Harvey, R.J., Harvey, K., O'Sullivan, G.A., Laube, B., Hülsmann, S., Geiger, J.R.P. and Betz, H. Impaired GABAA receptor clustering and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J. 26 (2007) 3888-3899.
Madry, C., Mesic, I., Bartholomäus, I., Nicke, A., Betz, H. and Laube, B. Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function. Biochem. Biophys. Res. Comm. 354 (2007) 102-108.
Saiyed, T., Paarmann, I., Schmitt, B., Haeger, S., Sola, M., Schmalzing, G., Weissenhorn, W. and Betz, H. Molecular basis of gephyrin clustering at inhibitory synapses: Role of G- and E-domain interactions. J. Biol. Chem. 282 (2007) 5625-5632.
Scheschonka, A., Tang, Z. and Betz, H.Sumoylation in neurons: nuclear and synaptic roles? Trends Neurosci. 30 (2007) 85-91.
Scheschonka, A., Betz, H. and Becker, C.-M. Nervengewebe. In: Löffler, G., Petrides, P.E. and Heinrich, P. (Eds.), Springer Press Heidelberg (2006) pp. 1023-1051.
Eulenburg. V., Becker, K., Gomeza, J., Schmitt, B., Becker, C.-.M. and Betz, H. Mutations within the human GlyT2 (SLC6A5) gene associated with hyperekplexia. Biochem. Biophys. Res. Comm. 348 (2006) 400-405.
Betz, H, and Laube, B. Glycine receptors: recent insights into their structural organization and functional diversity. J. Neurochem. 97 (2006) 1600-1610.
Gomeza, J., Armsen, W., Betz, H. and Eulenburg, V. Lessons from the knocked-out glycine transporters. Springer, Berlin-Heidelberg. Handbook Exp. Pharmacol. 175 (2006) 457-483.
Parnas, I., Rashkovan, G., O'Connor, V., El Far, O., Betz, H. and Parnas, H. The role of NSF in neurotransmitter release: a peptide microinjection study at the crayfish neuromuscular junction. J. Neurophysiol. 96 (2006) 1053-60.
Bertaso, F., Lill, Y., Airas, J.M., Espeut, J., Blahos, J., Bockaert, J., Fagni, L., Betz, H. and El Far, O. MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. J. Neurochem. 99 (2006) 288-298.
Hirzel, K., Müller, U., Latal, T., Hülsmann, S., Grudzinska, J., Seeliger, M., Betz, H. and Laube, B.
Hyperekplexia phenotype of glycine receptor a1 subunit mutant mice identifies Zn2+ as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52 (2006) 679-690.
Betz, H., Gomeza, J., Armsen, W., Scholze, P. and Eulenburg, V. Glycine transporters: essential regulators of synaptic transmission. Biochem. Soc. Trans. 34 (2006) 55-58.
Paarmann, I., Saiyed, T., Schmitt, B. and Betz, H. Gephyrin: does splicing affect its function? Biochem. Soc. Trans. 34 (2006) 45-47.
Bausen, M., Fuhrmann, J.C., Betz, H. and O'Sullivan, G.A. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Mol. Cell. Neurosci. 31 (2006) 376-386.
Olsen, R.W. and Betz, H. GABA and glycine. In: Basic Neurochemistry, G.J. Siegel, R.W. Albers, S.T. Brady and D.L. Price (Eds.) Elsevier Academic Press, Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo, Chapter 16 (2005) pp. 291-301.
Kondratskaya, E.L., Betz, H., Kristhal, O.A. and Laube, B. The ß subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology 49 (2005) 945-951.
Tang, Z., El Far, O., Betz, H. and Scheschonka, A. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. J. Biol. Chem. 280 (2005) 38153-38159.
O'Sullivan, G.A., Kneussel, M., Elazar, Z. and Betz, H. GABARAP is not essential for GABAA receptor targeting to the synapse. Eur. J. Neurosci. 22 (2005) 2644-2648.
Eulenburg, V., Armsen, W., Betz, H. and Gomeza, J. Glycine transporters: essential regulators of neurotransmission. Trends Biochem. Sci. 30 (2005) 325-333.
Horiuchi, M., Loebrich, S., Brandstätter, J.H., Kneussel, M. and Betz H. Cellular localization and subcellular distribution of Unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2. J. Neurochem. 94 (2005) 307-315.
Grudzinska, J., Schemm, R., Haeger, S., Nicke, A., Schmalzing, G., Betz, H. and Laube, B. The ß subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45 (2005) 727-739.
Banks, G.B., Kanjhan, R., Wiese, S., Kneussel, M., Wong, L.M., O'Sullivan, G., Sendtner, M, Bellingham, M.C., Betz, H.and Noakes, P.G. Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. J. Neurosci. 25 (2005) 1249-1259.
Laube, B., Schemm, R. and Betz, H. Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor. Neuropharmacology 47 (2004) 994-1007.
Laube, B. and Betz, H. Glycine receptors. Encyclopedia of Biological Chemistry Vol. 2 (2004) 237-243, Elsevier Inc.
Sola, M., Bavro, V.N., Timmins, J., Franz, T., Ricard-Blum, S., Schoehn, G., Ruigrok, R.W.H., Paarmann, I., Saiyed, T., O'Sullivan, G.A., Schmitt, B., Betz, H. and Weissenhorn, W. Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO J. 23 (2004) 2510-2519.
O'Shea, S.M., Becker, L., Weiher, H., Betz, H. and Laube, B. Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice. J. Neurosci. 24 (2004) 2322-2327.
Harvey, R.J, Depner, U.B., Wässle, H,, Ahmadi, S., Heindl, C., Reinold, H., Smart, T.G., Harvey, K., Schütz, B., Abo-Salem, O.M., Zimmer, A., Poisbeau, P., Welzl, H., Wolfer, D.P., Betz, H., Zeilhofer, H.U. and Müller, U.
GlyR a3: An essential target for spinal PGE2-mediated inflammatory pain sensitization. Science 304 (2004) 884-887.
Baliova, M., Betz, H. and Jursky, F. Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2. J. Neurochem. 88 (2004) 227-232.
Ohno, K., Koroll, M., El Far, O., Gomeza,J. and Betz, H. The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1. Mol. Cell. Neurosci. 26 (2004) 518-529.
Gomeza, J., Ohno, K. and Betz, H. Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises. Curr. Op. Drug Disc. & Dev. 6 (2003) 675-682.
Haverkamp, S., Müller, U., Harvey, K., Harvey, R.J., Betz, H. and Wässle, H. Diversity of glycine receptor in the mouse retina: localization of the a3 subunit. J. Comp. Neurol. 465 (2003) 524-539.
Neugebauer, R., Betz, H. and Kuhse, J. Expression of a soluble glycine binding domain of the NMDA receptor in Escherichia coli. Biochem. Biophys. Res. Comm. 305 (2003) 476-483.
Gomeza, J., Ohno, K., Hülsmann, S., Armsen, W., Eulenburg, V., Richter, D.W., Laube, B. and Betz, H. Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron 40 (2003) 797-806.
Gomeza, J., Hülsmann, S. Ohno, K., Eulenburg, V., Szöke, K., Richter, D. and Betz, H. Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron 40 (2003) 785-796.
Grosskreutz, Y., Betz, H. and Kneussel, M Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene. Biochem. Biophys. Res. Comm. 301 . (2003) 450-455.
Noh, J.H., Choi, S., Lee, J.H, Betz, H., Kim, J.I., Park, C.S., Lee, S.M. and Nah, S.Y. Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes. Mol. Cells 28 (2003) 34-39.
Foucaud, B., Laube, B., Schemm, R., Kreimeyer, A., Goeldner, M. and Betz, H. Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling. J. Biol. Chem. 278 (2003) 24011-24017.
Birkenfeld, J., Kartmann, B., Anliker, B., Ono, K., Schlötcke, B., Betz, H. and Roth, D. Characterization of Zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. Biochem. Biophys. Res. Comm. 302 (2003) 526-533.
Birkenfeld, J., Betz, H. and Roth, D. Identification of cofilin and LIM-domain containing protein kinase 1 as novel interaction partners of 14-3-3 ζ. Biochem. J. 369 (2003) 45-54.
Perret, P., Laube, B., Schemm, R., Betz. H., Goeldner, M. and Foucaud, B. Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites. Recept. Signal Transduct. Res. 22 (2002) 345-356.
Horikawa, H.P.M., Kneussel, M., El Far, O. and Betz, H. Interaction of synaptophysin with the AP-1 adaptor protein γ-adaptin. Mol. Cell. Neurosci. 21 (2002) 454-462.
Perroy, J., El Far, O, Bertaso, F., Pin, J.P., Betz, H., Bockaert, J. and Fagni, L. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. EMBO J. 21 (2002) 2990-2999.
El Far, O. and Betz, H G-protein coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes. Biochem. J. 365 . (2002) 329-336.
Bracher, A., Kadlec, J., Betz, H. and Weissenhorn, W. X-ray structure of a neuronal complexin/SNARE complex from squid. J. Biol. Chem. 277 (2002) 26517-26523.
El Far, O. and Betz, H. Synaptophysins: vesicular cation channels? J. Physiol. London 593 (2002) 332.
Jess, U.,El Far, O., Kirsch, J. and Betz, H. Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C. Biochem. Biophys. Res. Comm. 294 (2002) 272-279.
Laube, B., Maksay, G., Schemm, R. and Betz, H. Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol. Sci. 23 (2002) 519-527.
Fuhrmann, J.C., Kins, S., Rostaing, P., El Far, O., Kirsch, J., Sheng, M., Triller, A., Betz, H. and Kneussel, M. Gephyrin interacts with dynein light chains 1 and 2, components of dynein and myosin-Va motor protein complexes. J. Neurosci. 22 (2002) 5393-5402.
Bavro, V.N., Sola, M., Bracher, A., Kneussel, M., Betz, H. and Weissenhorn, W. Crystal structure of the GABA receptor associated protein GABARAP. EMBO Reports 3 (2002) 183-189.
Tintrup, H., Fischer, M., Betz, H. andKuhse, J. Exonic Sp1 sites are required for neural-specific expression of the glycine receptor ß subunit gene. Biochem. J. 355 (2001) 179-187.
Wittekindt, B., Malany, S., Schemm, R., Otvos, L., Maccecchini, M.L., Laube, B. and Betz, H. Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of Conantokin-G inhibition. Neuropharmacology 41 (2001) 753-761.
Birkenfeld, J., Betz, H. and Roth, D. Inhibition of neurite extension by overexpression of individual domains of LIM Kinase 1. J. Neurochem. 78 (2001) 924-927.
Grosskreutz, Y., Hermann, A., Kins, S., Fuhrmann, J. C., Betz, H. and Kneussel, M. Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biol. Chem. 382 (2001) 1455-1462.
El Far, O, Bofill-Cardona, E., Airas, J.M., O'Connor, V., Böhm, S., Freissmuth, M., Nanoff, C. and Betz, H. Mapping of calmodulin and Gβγ binding domains within the C-terminal region of the metabotropic glutamate receptor 7A. J. Biol. Chem. 276 (2001) 30662-30669.
Sola, M., Kneussel, M., Heck, I.S., Betz, H. and Weissenhorn, W. X-ray crystal structure of the trimeric N-terminal domain of gephyrin. J. Biol. Chem. 276 (2001) 25294-25301.
Büttner, C., Sadtler, S., Laube, B., Griffon, N., Betz, H. and Schmalzing, G. Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. J. Biol. Chem. 276 (2001) 42978-42985.
Airas, J.M., Betz, H. and El Far, O. PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding. FEBS Lett. 494 (2001) 60-63.
Maksay, G., Laube, B. and Betz, H. Subunit-specific bidirectional modulation of glycine receptors by neurosteroids. Neuropharmacology 41 (2001) 369-376.
Kneussel, M., Brandstätter, J.H., Gasnier, B., Feng, G., Sanes, J.R. and Betz, H. Gephyrin-independent clustering of postsynaptic GABAA receptor subtypes. Mol. Cell. Neurosci. 17 (2001) 973-982.
Hermann, A., Kneussel, M. and Betz, H. Identification of multiple gephyrin isoforms in different organs of the adult rat. Biochem. Biophys. Res. Comm. 282 (2001) 67-70.
Horiuchi, M., Nicke, A., Gomeza, J., Aschrafi, A., Schmalzing, G. and Betz, H. Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 98 (2001) 1448-1453.
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Schloss, P., Mayser, W. and Betz, H. The putative rat choline transporter CHOT transports creatine and is highly expressed in neural and muscle-rich tissues. Biochem. Biophys. Res. Comm. 199 (1994)1320-1325.
Matzenbach, B., Maulet, Y., Sefton, L., Coutier, B., Avner, P., Guénet, J.-L. and Betz, H. Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a hovel variant, alpha 4. J. Biol. Chem. 269 (1994)2607-2612.
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Kirsch, J., Malosio, M.-L., Wolter, I. and Betz, H. Distribution of gephyrin transcripts in the adult and developing rat brain. Eur. J. Neurosci. 5 (1993) 1109-1117.
Bormann, J., Rundström, N., Betz, H. and Langosch, D. Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and heterooligomers. EMBO J. 12 (1993) 3729-3737.
Betz, H. Diversity of neurotransmitter receptors in the CNS: implications for information processing. In: Exploring Brain Functions. Models in Neuroscience (Poggio, T.A. and Glaser, D.A., eds.) John Wiley and Sons, Chichester-New York-Brisbane-Toronto-Singapore (1993) 19-26.
Betz, H. Langosch, ,D., Rundström, N., Bormann, J., Kuryatov, A., Kuhse, J., Schmieden, V., Matzenbach, B. and Kirsch, A. Structure and biology of inhibitory glycine receptors. Ann. New York Acad. Sci. 707 (1993) 109-115.
Bommert, K. Charlton, ,M.P., DeBello, W., Chin, G., Betz, H. and Augustine, G.J. Inhibition of neurotransmitter release by C2 domain peptides implicates synaptotagmin in exocytosis at the squid giant synapse. Nature 363 (1993) 163-165.
Schuster, C.M., Ultsch, A., Schmitt, B. and Betz, H. Molecular analysis of Drosophila glutamate receptors. In: Comparative Molecular Neurobiology (Pichon, Y., ed.) Birkhäuser, Basel (1993) pp.234-240.
Bergmann, M., Schuster, T., Grabs, D., Marquèze-Pouey, B., Betz, H., Traurig, H,, Mayerhofer, A and Gratzl, M. Synaptophysin and synaptoporin expression in the rat olfactory system during development. Dev. Brain Res. 74 (1993) 235-244.
Kirsch, J., and Betz, H. Widespread expression of gephyrin, a putative glycine receptor-tubulin linker protein, at central synapses. Brain Res. 621 (1993) 301-310.
Becker, C.-M., Betz, H. and Schröder, H. Expression of inhibitory glycine receptors in postnatal rat cerebral cortex. Brain Res. 606 (1993) 220-226.
Ovtscharoff, W., Bergmann, M., Marquèze-Pouey, B., Knaus, P., Betz, H., Grabs, D., Reisert, I. and Gratzl, M. Ontogeny of synaptopyhsin and synaptoporin in the central nervous system: Differential expression in striatal neurons and their afferents during development. Dev. Brain Res. 72 (1993) 219-225.
Betz, H. Structure and function of inhibitory glycine receptors. Quart. Rev. Biophys. 25 (1992) 381-394.
Betz, H. Transmitter release from nerve terminals: A Ca2+-regulated, multiprotein process. Neuroscience Facts 3 (1992)74-75.
Schloss, P., Mayser, W., Gundelfinger, E.D. and Betz, H. Cross-linking of 125I-α-bungarotoxin to Drosophila head membranes identifies a 42 kDa toxin binding polypeptide. Neurosci. Lett. 145 (1992) 63-66.
Betz, H., Siebert, A. and Bommert, K. Neurotransmitter release from nerve terminals: a calcium-regulated multi-protein process. Proc. 20th Karolinska Institute Nobel Conference on Calcium Signalling (1992) pp. 91-92.
Pribilla, I., Tagaki, T., Langosch, D., Bormann, J. and Betz, H. Atypical M2 segment of the ß submit confers picrotoxin resistance to inhibitory glycine receptor channels. EMBO J. 11 (1992) 4305-4311.
Schloss, P., Mayser, W. and Betz, H. Neurotransmitter transporters: a novel family of integral plasma membrane proteins. FEBS Lett. 307 (1992) 76-80.
Betz, H., Schmieden, V. and Kuhse, J. Determinants of ligand binding to the inhibitory glycine receptor. In: Membrane Proteins: Structures, Interactions and Models (A. Pullmann et al., eds. Kluwer Acad. Publ., Amsterdam (1992) pp. 241-247.
Mayser, W., Schloss, P. and Betz, H. Primary structure and functional expression of a choline transporter expressed in the rat nervous system. FEBS Lett. 305 (1992) 31-36.
Takagi, T., Pribilla, I., Kirsch, J. and Betz, H. Coexpression of the receptor-associated protein gephyrin changes the ligand binding affinities of a2 glycine receptors. FEBS Lett. 303 (1992)178-180.
Langosch, D., Hoch, W. and Betz, H. The 93 kDa protein gephyrin and tubulin associated with the inhibitory glycine receptor are phosphorylated by an endogenous protein kinase. FEBS Lett. 298 (1992) 113-117.
Ultsch, A., Schuster, C.-M., Laube, B., Schloss, P., Schmitt, B. and Betz, H. Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit epxressed in the central nervous system. Proc. Natl. Acad. Sci. USA 89 (1992) 10484-10488.
Schmieden, V. Kuhse, ,J. and Betz, H. Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation. EMBO J. 11 (1992) 2025-2032.
Prior, P., Schmitt, B., Grenningloh, G., Pribilla, I., Multhaup, G., Beyreuther, K., Maulet, Y., Werner, P., Langosch, D., Kirsch, J. and Betz, H. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8 (1992) 1161-1170.
Hoch, W., Betz, H., Schramm, M., Wolters, I. and Becker, C.-M. Modulation by NMDA receptor antagonists of glycine receptor isoform expression in cultured spinal cord neurons. Eur. J. Neurosci. 4 (1992) 389-395.
Becker, C.-M., Schmieden, V. Tarroni, ,P., Strasser, U. and Betz, H. Isoform-selective deficit of glycine receptors in the mouse mutant spastic. Neuron 8 (1992) 283-289.
Mayser, W., Betz, H. and Schloss, P. Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene family. FEBS Lett. 295 (1991) 203-206.
Kirsch, J., Langosch, D., Prior, P., Littauer, U.Z., Schmitt, B. and Betz, H. The 93k protein of the postsynaptic glycine receptor complex binds to tubulin. J. Biol. Chem. 266 (1991) 22242-22245.
Betz, H. Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 (1991) 458-461.
Malosio, M.L., Marquèze-Pouey, B., Kuhse, J. and Betz, H. Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J. 10 (1991) 2401-2409.
Betz, H., Kuhse, J., Schmieden, V., Malosio, M.-L., Langosch, D., Prior, P., Schmitt, B. and Kirsch, J. How to build a glycinergic postsynaptic membrane. J. Cell Sci. S15 (1991) 23-25.
Schuster, C.M., Ultsch, A., Schloss, P., Cox, J.A., Schmitt, B. and Betz, H. Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle. Science 254 (1991) 112-114.
Naas, E., Schröder, H., Zilles, K., Becker, C.-M. and Betz, H. Corticale Glycinrezeptoren der Ratte: Laminäre, zelluläre und subzelluläre Lokalisation. Verh. Anat. Ges. 84 (1991) 605-607.
Ultsch, A., Schuster, C.M., Betz, H. and Wisden, W. In situ hybridization with oligonucleotides: a simplified method to detect Drosophila transcripts. Nucl. Acids Res.19 (1991) 3746.
Kuhse, J., Kuryatov, A., Maulet, Y., Malosio, M.L., Schmieden, V. and Betz, H. Alternative splicing generates two isoforms of the a2 subunit of the inhibitory glycine receptor. FEBS Lett. 283 (1991) 73-77.
Langosch, D., Hartung, K., Grell, E, Bamberg, E. and Betz, H. Ion channel formation by synthetic transmembrane segments of the inhibitory glycine. receptor - A model study. Biochem. Biophys. Acta 1063 (1991) 36-44.
Naas, E., Zilles, K., Gnahn, H., Betz, H., Becker, C.-M. and Schröder, H. Glycine receptor immunoreactivity in rat and human cerebral cortex. Brain Res. 561 (1991) 139-146.
Betz, H., Becker, C.-M., Schmieden, V., Hoch, W., Pribilla, I., Langosch, D., Malosio, M.-L. and Kuhse, J. Molecular biology of inhibitory glycine receptors. In: Transmitter Amino Acid Receptors: Structures, Transduction and Models for Drug Development (Barnard, E.A. & Costa, E., eds.) Thieme, Stuttgart-New York (1991) pp. 503-509.
Kuhse, J., Becker, C.-M., Schmieden, V., Hoch, W., Pribilla, I., Langosch, D., Malosio, M.-L., Muntz, M. and Betz, H. Heterogeneity of the inhibitory glycine receptor. In: Molecular and Cellular Mechanisms of Alcohol and Anesthetics (Rubin, E., Miller, K.W. & Roth, S.H., eds.) Ann. New York Acad. Sci. 625 (1991) 129-135.
Marquèze-Pouey, B., Wisden, W., Malosio, M.-L. and Betz, H. Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system. J. Neurosci. 11 (1991) 3388-3397.
Malosio, M.-L., Grenningloh, G., Kuhse, J., Schmieden, V., Schmitt, B., Prior, P. and Betz, H. Alternative splicing generates two variants of the a1 subunit of the inhibitory glycine receptor. J. Biol. Chem. 266 (1991) 2048-2053.
Schröder, S., Hoch, W., Becker, C.-M., Grenningloh, G. and Betz, H. Mapping of antigenic epitopes on the a1 subunit of the inhibitory glycine receptor. Biochemistry 30 (1991) 42-47.
Schloss, P., Betz, H., Schröder, C and Gundelfinger, E. D. Neuronal nicotinic acetylcholine receptors in Drosophila: ALS and ARD proteins are subunits of a high-affinity α- bungarotoxin binding complex. J. Neurochem. 57 (1991) 1556-1562.
Betz, H., Langosch, D., Hoch, W., Prior, P, Pribilla, I., Kuhse, J., Schmieden, V., Malosio, M.-L., Matzenbach, B., Holzinger, F., Kuryatov, A., Schmitt, B., Maulet, Y. and Becker, C.-M. Structure and expression of inhibitory glycine receptors. In: Neuroreceptor Mechanisms in Brain (Kito, S. ed.), Plenum Press, New York (1991) pp. 421-429.
Sawruk, E., Udri, C., Betz, H. and Schmitt, B. SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two a-subunits. FEBS Lett. 273 (1990) 177-181.
Kuhse, J. Schmieden, V. and Betz, H. Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor. J. Biol. Chem. 265 (1990) 22317-22320.
Knaus, P., Marquèze-Pouey, B., Scherer, H. and Betz, H. Synaptoporin, a novel putative channel protein of synaptic vesicles. Neuron 5 (1990) 453-462.
Betz, H. Ligand-gated ion channels in the brain: The amino acid receptor superfamily. Neuron 5 (1990) 383-392.
Thomas, L. and Betz, H. Synaptophysin binds to physophilin, a putative synaptic plasma membrane protein. J. Cell Biol. 111 (1990) 2041-2052.
Sawruk, E, Schloss, P., Betz, H. amd Schmitt, B. Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated a-subunit. EMBO J. 9 (1990) 2671-2677.
Econs, M. J., Pericak-Vance, M.A., Betz, H., Bartlett, R.J., Speer, M.C. and Drezner, M.K. The human glycine receptor: A new probe that is linked to the X-linked hypophosphatemic rickets gene. Genomics 7 (1990) 439-441.
Kuhse, J., Schmieden, V. and Betz, H. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. Neuron 5 (1990) 867-873.
Kirsch, J., Littauer, U. Z., Schmitt, B., Prior, P., Thomas, L. and Betz, H. Neuraxin corresponds to a C-terminal fragment of microtubule-associated protein 5 (MAP5). FEBS Lett. 262 (1990)259-262.
Langosch, D., Becker, C.-M. and Betz, H. The inhibitory glycine receptor: A ligand-gated chloride channel of the central nervous system. Eur. J. Biochem. 194 (1990)1-8.
Grenningloh, G., Pribilla, I., Prior, P., Multhaup, G., Beyreuther, K., Taleb, O. and Betz, H. Cloning and expression of the 58 kd ß subunit of the inhibitory glycine receptor. Neuron 4 (1990) 963-970.
Grenningloh, G., Schmieden, V., Schofield, P. R., Seeburg, P. H, Siddique, T., Mohandas, T.K., Becker, C.-M. and Betz, H. Alpha subunit variants of the human glycine receptor: Primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9 (1990) 771-776.
Betz, H. Homology and analogy in transmembrane channel design: Lessons from synaptic membrane proteins. Biochemistry 29 (1990) 3591-3599.
Knaus, P. and Betz, H. Mapping of a dominant immunogenic region of synaptophysin, a major membrane protein of synaptic vesicles. FEBS Lett. 261 (1990) 358-360.
Langosch, D., Betz, H. and Becker, C.-M. Molecular structure and developmental regulation of the inhibitory glycine receptor. In: Glycine neurotransmission (O.P. Ottersen & J. Storm-Mathisen, eds.) John Wiley and Sons, Chichester/New York (1990) pp. 67-82.
Zopf, D., Dineva, B., Betz, H. and Gundelfinger, E.D. Isolation of the chicken middle-molecular weight neurofilament (NF-M) gene and characterization of its promoter Nucl. Acids Res. 18 (1990) 521-529.
Schmidt, R.R. and Betz, H. Cross-linking of ß-bungarotoxin to chick brain membranes. Identification of subunits of a putative voltage-gated K+ channel. Biochemistry 28 (1989) 8346-8350.
Vetter, J. and Betz, H. Expression of synaptophysin in the rat phaeochromocytoma cell line PC12. Exp. Cell Res. 184 (1989) 360-366.
Tohyama, M., Wanaka, A., Araki, T., Betz, H.and Malbon, C.C. Localization of glycine and beta-adrenergic receptors in the rat brain. Arch. Histol. Cytol. 52 (1989) 39-48.
Rienitz, A., Grenningloh, G., Hermans-Borgmeyer, I., Kirsch, J., Prior, P., Littauer, U.Z. Gundelfinger, E.D., Schmitt, B. and Betz, H. Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5. EMBO J. 8 (1989) 2879-2888.
Siddique, T, Phillips, K., Betz, H., Grenningloh, G., Warner, K., Hung, W.-Y, Laing, N. and Ross, A.D. RFLPs of the gene for the human glycine receptor on the X-chromosome. Nucl. Acids Res. 4 (1989) 1785.
Hoch, W., Betz, H. and Becker, C.-M. Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor. Neuron 3 (1989) 339-348.
Sontheimer, H., Becker, C.-M., Pritchett, D.B., Schofield, P.R., Grenningloh, G. Kettenmann, H., Betz, H. and Seeburg, P. H. Functional chloride channels by mammalian cell expression of rat glycine receptor subunit. Neuron 2 (1989) 1491-1497.
Langosch, D., Grenningloh, G., Schmieden, V., Prior, P., Malosio, M.-L., Schmitt, B. and Betz, H. The postsynaptic glycine receptor - a member of the neurotransmitter-gated channel protein family. In: NATO ASI Series (Maelicke, A., ed.) Molecular biology of neuroreceptors and ion channels, Vol. H32 (1989) pp. 125-130.
Hoch, W., Betz, H. and Becker, C.-M. Immunological identification of a neonatal glycine receptor isotype expressed during early postnatal development. In: NATO ASI Series (Maelicke, A., ed.) Molecular biology of neuroreceptors and ion channels, Vol. H32 (1989) pp. 131-138.
Gundelfinger, E.D., Hermanns-Borgmeyer, I., Schloss, P., Sawruk, E., Udri, C., Vingron, M., Betz, H. and Schmitt, B. Ligand-gated ion channels of Drosophila. In: NATO ASI Series (Maelicke, A., ed.) Molecular biology of neuroreceptors and ion channels, Vol. H32, Springer Berlin-Heidelberg (1989)pp. 69-81.
Thomas, L., Knaus, P. and Betz, H. Comparison of the presynaptic vesicle component synaptophysin and gap junction proteins: a clue for neurotransmitter release? In: NATO ASI Series (Maelicke, A., ed.) Molecular biology of neuroreceptors and ion channels, Vol. H32, Springer Berlin-Heidelberg (1989) pp. 283-298.
Schmieden, V., Grenningloh, G., Schofield, P. R. and Betz, H. Functional expression in Xenopus oocytes of the strychnine binding 48-kd subunit of the glycine receptor. EMBO J. 8 (1989) 695-700.
Betz, H., Gundelfinger, E. D., Hermans-Borgmeyer, I., Sawruk, E., Schloss, P. and Schmitt, B. Central nicotinic acetylcholine receptors in the chicken and Drosophila CNS: Biochemical and molecular biology approaches. In: Central cholinergic transmission (Frotscher, M. and Misgeld, U., eds.) Birkhäuser, Basel-Boston-Berlin (1989) pp. 183-189.
Zopf, D., Sonntag, V., Betz, H. and Gundelfinger, E.D. Developmental accumulation and heterogeneity of myelin basic protein transcripts in the chick visual system. Glia 2 (1989) 241-249.
Hermans-Borgmeyer, I., Hoffmeister, S., Sawruk, E., Betz, H., Schmitt, B. and Gundelfinger, E.D. Neuronal acetylcholine receptors in Drosophila: Mature and immature transcripts of the ard gene in the developing central nervous system. Neuron 2 (1989)1147-1156.
Becker, C.-M., Hoch, W. and Betz, H. Sensitive immunoassay shows selective association of peripheral and integral membrane proteins of the inhibitory glycine receptor complex. J. Neurochem. 53 (1989) 125-131.
Betz, H. Molekularbiologie der inhibitorischen Synapse. Arzneimittelforschung 39 (1989) 138-143.
Murakami, T., Araki, T., Yamano, M., Wanaka, A., Betz, H. and Tohyama, M. Localization of the glycine receptors in the rat central nervous system: an immunocytochemical analysis Adv. Exp. Med. Biol. 236 (1988) 71-80.
Schmidt, R.R. and Betz, H. The ß-bungarotoxin binding protein from chick brain: binding sites for different neuronal K+ channel ligands co-fractionate upon partial purification. FEBS Lett. 240 (1988) 65-70.
Betz, H., Becker, C.-M., Grenningloh, G., Gundelfinger, E.D., Hoch, W., Kraus, P., Langosch, D., Prior, P., Schmitt, B. and Thomas, L. Structural organization of neuronal channel proteins. In: Molecular basis of biomembrane transport (Palmieri, F. and Quagliarello, E., eds.) Elsevier Publ. (1988) pp. 69-70.
Hermanns-Borgmeyer, I., Sawruk, E., Schloß, P., Gundelfinger, E.D. and Betz, H. Biochemical and molecular biology approaches to central nicotinic acetylcholine receptors. In: Nicotinic Acetylcholine Receptors in the Nervous System, NATO ASI Series, Vol. H25 (Clementi, F., Gotti, C. and Sher, E., eds.), Springer Verlag (1988) pp. 77-88.
Becker, C.-M., W. Hoch, and Betz, H. Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J. 7 (1988) 3717-3726.
Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W.W. and Betz, H. Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 242 (1988) 1050-1053.
Schloss, P., Hermanns-Borgmeyer, I., Betz, H. and Gundelfinger, E.D. Neuronal acetylcholine receptors in Drosophila: the ARD protein is a component of a high-affinity a-bungarotoxin binding complex. EMBO J. 7 (1988) 2889-2894.
Sawruk, E., Hermanns-Borgmeyer, I., Betz, H. and Gundelfinger, E.D. Characterization of an invertebrate nicotinic acetylcholine receptor gene: The ard gene of Drosophila melanogaster. FEBS Lett. 235 (1988) 40-46.
Betz, H. and Becker, C.-M. The mammalian glycine receptor: Biology and structure of a neuronal chloride channel protein. Neurochemistry Int. 13 (1988) 137-146.
Langosch, D., Thomas, L. and Betz, H. Conserved quarternary structure of ligand-gated ion channels: The postsynaptic glycine receptor is a pentamer. Proc. Natl. Acad. Sci. USA 85 (1988) 7394-7398.
Betz, H. Neurotransmitter-gated chloride channels in the central nervous system. In: Hormones and Cell Regulation, Vol. 165 (1988) pp. 127-132.
Zopf, D., Grenningloh, G., Hermans-Borgmeyer, I., Rienitz, A., Becker, C.-M., Schmitt, B. E. Gundelfinger and Betz, H. Molecular biology approaches to the function and development of CNS synapses. In: Cellular and Molecular Basis of Neuronal Signaling, NATO ASI Series, Vol. H21 (Zimmermann, H., ed.) Springer Berlin-Heidelberg (1988) pp. 507-524.
Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen,, Beyreuther, K. Gundelfinger, E.D.and Betz, H Molecular cloning of the antagonist-binding subunit of the glycine receptor. J. Receptor Res. 8 . (1988) 183-193.
Araki, T., Yamano, M., Muramaki, T., Wanaka, A., Betz, H. and Tohyama, M. Localization of glycine receptors in the rat central nervous system: an immunocytochemical analysis using monoclonal antibody. Neuroscience 25 (1988) 613-624.
Schmidt, R. R., Betz, H. and Rehm, H. Inhibition of ß-bungarotoxin binding to brain membranes by MCD-peptide, toxin I and EGTA. Biochemistry 27 (1988) 963-967.
Grenningloh, G., Gundelfinger, E., Schmitt, B., Betz, H., Darlison, M.G., Barnard, E.A., Schofield, P.R. and Seeburg, P.H. Glycine vs GABA receptors. Nature 330 (1987) 25-26.
Becker, C.-M. and Betz, H. Strychnine: useful probe or not? Trends Pharmacol. Sci. 8 (1987) 379-380.
Leube, R.E., Kaiser, P., Seiter, A., Zimbelmann, R., Franke, W.W., Rehm, H., Knaus, P., Prior, P., Betz, H., Reinke, H., Beyreuther, K. and Wiedenmann, B. Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA. EMBO J. 6 (1987) 3261-3268.
Geyer, S.W., Gudden, W., Betz, H., Gnahn, H. and Weindl, A. Co-localization of choline acetyltransferase and post-synaptic glycine receptors in motoneurons of rat spinal cord demonstrated by immunocytochemistry. Neurosci. Lett. 82 (1987) 11-15.
Zopf, D., Hermans-Borgmeyer, I., Gundelfinger, E.D. and Betz, H. Identification of gene products expressed in the developing chick visual system: characterization of a middle-molecular weight neurofilament (NF-M) cDNA. Genes & Development 1 (1987) 699-708.
Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen, M., Beyreuther, K. E. D. Gundelfinger and Betz, H. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328 (1987) 215-220.
Nakajima, Y., Tuttle, R., Masuko, S., Betz, H. and Pfeiffer, F. Synapses on the Mauthner cell of the goldfish; Thin-section, freeze-fracture and immunocytochemical studies. J. Electron Microscop. Tech. 6 (1987) 143-154.
Rienitz, A., Becker, C.-M., Betz, H. and Schmitt, B. The chloride channel blocking agent, TBPS, binds to the GABA/benzodiazepine, but not to the glycine receptor. Neurosci. Lett. 76 (1987) 91-95.
Betz, H., Schmitt, B., Becker, C.-M., Grenningloh, G., Rienitz, A., Knaus, P., Hermans-Borgmeyer, I., Zopf, D., Schloß, P., Sawruk, E., Gundelfinger, E and Rehm, H. Biochemistry and molecular biology of receptors and ion channels in the central nervous system (CNS). In: Receptors and Ion Channels of Excitable Membranes (Y. A. Ovchinnikov & F. Hucho, eds.) Walter de Gruyter & Co., Berlin-New York (1987) pp. 109-115.
Betz, H. Structure and biology of the mammalian glycine receptor. Trends Neurosci. 10 (1987) 113-117.
Schmitt, B., Knaus, P., Becker, C.-M. and Betz, H. The Mr 93000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein. Biochemistry 26 (1987) 805-811.
Betz, H., Schmitt, B., Becker, C.-M., Grenningloh, G. and Rienitz, A. The glycine receptor. In: The Molecular Biology of Receptors (Strosberg, D., ed.) Ellis Horwood Ltd., Chichester and Verlag Chemie Weinheim (1987) pp. 128-138.
Betz, H., Schmitt, B., Becker, C.-M., Grenningloh, G., Rienitz, A. Hermans-Borgmeye, I., Zopf, D., Schloß, P., Sawruk, E. and Gundelfinger, E. Structure and biology of CNS neurotransmitter receptors. Biochem. Soc. Transactions 15 (1986) 107-108.
Gundelfinger, E. D., Hermans-Borgmeyer, I., Zopf, D., Sawruk, E., and Betz, H. Characterization of the mRNA and the gene of a putative neuronal nicotinic acetylcholine receptor protein from Drosophila. In: The Nicotinic Acetylcholine Receptor (A. Maelicke ed.) NATO ASI Series, Vol. H3 (1986) pp. 437-446.
Betz, H. Zentralnervöse Synapse: ein neues Begegnungsfeld von Hirnforschung und Molekularbiologie. Futura 3 (1986) 14-18.
Nakajima, Y., Tuttle, R., Masuko, S., Betz, H. and Pfeiffer, F. Ultrastructural studies on neuroreceptors and gap junctions of the goldfish Mauthner cell. Proc. XIth Int. Cong. on Electron Microscopy, Kyoto (1986) pp. 2041-2044.
Knaus, P., Betz, H. and Rehm, H. Expression of synaptophysin during postnatal development of the mouse brain. J. Neurochem. 47 (1986) 1302-1304.
Hermans-Borgmeyer, I., Zopf, D., Ryseck, R.-P., Hovemann, B., Betz, H. and Gundelfinger, E. Primary structure and developmental expression of a Drosophila neuronal acetylcholine receptor mRNA. EMBO J. 5 (1986) 1503-1508.
Betz, H., Schmitt, B., Becker, C.-M., Grenningloh, G. and Rienitz, A. The vertebrate glycine receptor protein. Biochem. Soc. Transactions 52 (1986) 57-63.
Rehm, H., Wiedenmann, B. and Betz, H. Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. EMBO J. 5 (1986) 535-541.
Becker, C.-M., Hermans-Borgmeyer, I., Schmitt, B. and Betz, H. The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization. J. Neurosci. 6 (1986) 1358-1364.
Schneider, M., Adee, C., Betz, H. and Schmidt, J. Biochemical characterization of two nicotinic receptors from the optic lobe of the chick. J. Biol. Chem. 260 (1985) 14505-14512.
Betz, H., Schmitt, B., Grenningloh, G., Becker, C.-M. and Hermans, I. The glycine receptor. In: Neurobiochemistry Springer Verlag Heidelberg (1985) pp. 113-119.
Altschuler, R. A., Betz, H., Parakkal, M.H., Reeks, K.A. and Wenthold, R.J. Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor. Brain Res. 369 (1985) 316-320.
Triller, A., Cluzeaud, ,A., Pfeiffer, F., Betz, H. and Korn, H. Distribution of glycine receptor at central synapses: an immuno-electron-microscopy study. J. Cell Biol. 101 (1985) 683-688.
Betz, H., Grenningloh, G. and Schmitt, B. The glycine receptor of rat spinal cord: progress in the investigation of a neuronal ion channel protein. In: Molecular Basis of Nerve Activity (Changeux, Hucho, Maelicke and Neumann, eds.) Walter de Gruyter & Co., Berlin (1985) pp. 263-272.
Betz, H. The glycine receptor of rat spinal cord: exploring the site of action of the plant alkaloid strychnine. Angew. Chem. 97, 363-368 Angew. Chem. Int. Ed. 24 (1985) 365-370.
Graham, D., Pfeiffer, F., Simler, R. and Betz, H. Purification and characterization of the glycine receptor of rat spinal cord. Biochemistry 24 (1985) 990-994.
Betz, H. Neues von der Nervenzellmembran: Fortschritte bei der Strukturanalyse transmembranärer Ionenkanäle. Naturwissenschaften 71 (1984) 363-368.
Betz, H. and Pfeiffer, F. Der Glyzinrezeptor: Untersuchungen zur Proteinstruktur eines chemisch kontrollierten Ionenkanals. Funkt. Biol. Med. 3 (1984) 65-68.
Rehm, H. and Betz, H. Solubilization and characterization of the ß-bungarotoxin binding protein of chick brain. J. Biol. Chem. 259 (1984) 6865-6869.
Betz, H. and Pfeiffer, F. Monoclonal antibodies against the a-bungarotoxin binding protein of chick optic lobe. J. Neurosci. 4 (1884) 2095-2105.
Graham, D., Pfeiffer, F. and Betz, H. Characterization and purification of the glycine receptor of pig spinal cord. In: Investigations of membrane-located receptors (Reid, Cook and Morre, eds.)Plenum Press, New York (1984) pp. 500-511.
Betz, H., Graham, D., Pfeiffer, F. and Rehm, H. ß-Bungarotoxin and strychnine as tools to characterize neurotransmitter receptors of the central nervous system. In: Toxins as tools in neurochemistry (Hucho, F., ed.), Walter de Gruyter & Co., Berlin (1983) pp. 245-255.
Rehm, H. and Betz, H. ß-Bungarotoxin; new aspects of an old approach to the presynaptic membrane. In: Toxins as tools in neurochemistry (Hucho, F., ed.), Walter de Gruyter & Co., Berlin (1983) pp. 341-351.
Betz, H. Regulation of the α-bungarotoxin receptor in chick retina cultures: effects of membrane depolarization, cyclic nucleotide derivates and Ca2+. J. Neurosci. 3 (1983) 1333-1341.
Rehm, H. and Betz, H. Identification by crosslinking of a ß-bungarotoxin binding polypeptide in chick brain membranes. EMBO J. 2 (1983) 1119-1122.
Graham, D., Pfeiffer, F. and Betz, H. Photoaffinity-labelling of the glycine receptor of rat spinal cord. Eur. J. Biochem. 131 (1983) 519-525.
Betz, H. Interaction of histrionicotoxin with the putative nicotinic acetylcholine receptor of the chick visual system. Neurosci. Lett. 33 (1983) 153-158.
Graham, D., Pfeiffer, F. and Betz, H. Photoaffinity-labelling of the glycine receptor from rat spinal cord. In: Neuroreceptors (Hucho, F., ed.), Walter de Gruyter & Co., Berlin (1982) pp. 139-144.
Pfeiffer, F., Graham, D. and Betz, H. Solubilization and purification of the postsynaptic glycine receptor from rat spinal cord. In: Neuroreceptors (Hucho, F., ed.), Walter de Gruyter & Co., Berlin (1982) pp. 145-150.
Betz, H. and Rehm, H. Characterization of a putative nicotinic acetylcholine receptor in chick retina. In: Neuroreceptors (Hucho, F., ed.), Walter de Gruyter & Co., Berlin (1982) pp. 165-171.
Rehm, H. and Betz, H. Binding of ß-bungarotoxin to synaptic membrane fractions of chick brain. J. Biol. Chem. 257 (1982) 10015-10022.
Betz, H., Graham, D.,and Rehm, H. Identification of polypeptide chains associated with a putative neuronal nicotinic acetylcholine receptor. J. Biol. Chem. 257 (1982) 11390-11394.
Pfeifffer, F., Graham, D. and Betz, H. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J. Biol. Chem. 257 (1982) 9389-9393.
Betz, H. Differential down-regulation of nicotinic and muscarinic acetylcholine receptors in primary cultures of chick retina. Neurosci. Lett. 28 (1982) 265-268.
Graham, D, Pfeiffer, F. and Betz, H. Avermectin Bla antagonizes strychnine binding to membranes from rat spinal cord. Neurosci. Lett. 29 (1982) 173-176.
Rehm, H., Schäfer, T. and Betz, H. ß-Bungarotoxin-induced cell death of neurons in chick retina. Brain Res. 250 (1982) 309-319.
Betz, H. and Müller, U. Culture of chick embryo neural retina in serum-free medium: expression of cholinergic proteins. Exp. Cell Res. 138 (1982) 297-302.
Rehm, H. and Betz, H. Unmasking of a second binding site for α-bungarotoxin in membranes from chick retina. Biochem. Biophys. Res. Comm. 102 (1981) 1385-1392.
Graham, D., Pfeiffer, F. and Betz, H. UV light-induced cross-linking of strychnine to the glycine receptor of rat spinal cord membranes. Biochem. Biophys. Res. Comm. 102 (1981) 1330-1335.
Betz, H. Choline acetyltransferase activity in chick retina cultures: effects of membrane depolarising agents. Brain Res. 223 (1981) 190-194.
Pfeiffer, F. and Betz, H. Solubilisation of the glycine receptor from rat spinal cord. Brain Res. 226 (1981) 273-279.
Betz, H. Characterization of the a-bungarotoxin receptor in chick embryo retina. Eur. J. Biochem. 117 (1981) 131-139.
Betz, H. The acetylcholine receptor: control of its synthesis, stability and cell surface distribution. In: Metabolic Interconversion of Enzymes (Holzer, H., ed.) Springer (1981) pp. 372-377.
Betz, H. and Rehm, H. Assembly and turnover of the subsynaptic membrane. In: Biogenesis of cell organelles (Weiss, H. and Sebald, W. eds.), Springer (1980) pp. 175-186.
Betz, H. Effects of drug-induced paralysis and depolarisation on acetylcholine receptor and cyclic nucleotide levels of chick muscle cultures. FEBS Lett. 118 (1980) 289-292.
Betz, H., Bourgeois J. P. and Changeux, J. P. Evolution of cholinergic proteins in developing slow and fast skeletal muscles in chick embryo. J. Physiol. (London) 302 (1980) 197-218.
Betz , H. and Changeux, J. P. Regulation of muscle acetylcholine receptor synthesis in vitro by derivatives of cyclic nucleotides. Nature 278 (1979) 749-752.
Betz H. Loss of sporulation ability in a yeast mutant with low proteinase A levels. FEBS Lett. 100 (1979) 171-174.
Bourgeois, J. P., Betz, H. and Changeux, J.P. Effets de la paralysie chronique de l'embryon de poulet par le flaxedil sur le developpement de la junction neuromusculaire. C. R. Acad. Sci. Paris 286 (1978) 773-776.
Betz, H. Protein degradation and sporulation in yeast. In: Cellular differentiation in microorganisms, animals, and plants. (Nover, L. & Mothes, K., eds.) Gustav Fischer, Jena-Elsevier, North Holland (1977) pp., 243-255.
Betz, H. Protein degradation during the differentiation of eukaryotic cells: studies on the sporulation of Saccharomyces cerevisiae and on the formation of the neuromuscular junction in the chick embryo. Acta Biol. Med. Germ. 36 (1977) 1525-1530.
Betz, H., Bourgeois, J.P. and Changeux, J.P. Evidence for degradation of acetylcholine nicotinic receptors during the development of skeletal muscle in the chick embryo. FEBS Lett. 77 (1977) 219-224.
Betz, H. Der proteolytische Apparat der Hefezelle und seine Bedeutung für die Sporulation. Habilitationsschrift (1976) Universität Freiburg i. Br.
Betz, H. and Weiser, U. Protein degradation during yeast sporulation. Enzyme and cytochrome patterns. Eur. J. Biochem. 70 . (1976) 385-395.
Betz, H. Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells. Biochem. Biophys. Res. Comm. 72 (1976) 121-130.
Betz, H. and Weiser U. Protein degradation and proteinases during yeast sporulation Eur. J. Biochem. 62 (1976) 65-76.
Hinze, H., Betz, H., Saheki, T. and Holzer, H. Formation of a complex between yeast proteinases A and B. Hoppe-Seyler's Z. Physiol. Chem. 356 (1975) 1259-1264.
Betz, H. Levels and turnover of the proteinase B inhibitors in yeast. Biochem. Biophys. Acta 404 (1975) 142-151.
Holzer, H., Betz, H. and Ebner, E. Intracellular proteinases in microorganisms. In: Current Topics in Cellular Regulation 9 (1975)103-156.
Matern, H., Betz, H. and Holzer, H. Compartmentation of inhibitors of proteinases A and B and carboxypeptidase Y in yeast. Biochem. Biophys. Res. Comm. 60 (1974) 1051-1057.
Betz, H., Hinze, H. and Holzer, H. Isolation and properties of two inhibitors of proteinase B from yeast. J. Biol. Chem. 249 (1974) 4515-4521.
Saheki, T., Betz, H. and Holzer, H. Characterization of a macromolecular protease-inhibitor from yeast. In: Intracellular Proteincatabolism (Bohley, P., eds.) Verl. J. A. Barth, Leipzig (1974/76)pp., 194-200.
Holzer, H., Katsunuma, T., Schoett, E.G., Ferguson, A.R., Hasilik, A. and Betz, H. Studies on a tryptophan-synthase-inactivating system from yeast. Adv. Enzyme Reg. 11 (1973) 53-60.
Betz, H. and Holzer, H. Properties and regulatory role of a yeast proteinase inhibitor. Proc. Third Internat. Spec. Symp. on Yeasts, Otaniemi/Helsinki, Part II . (1973) pp. 67-80.
Ferguson, A.R., Katsunuma, T., Betz, H. and Holzer, H. Purification and properties of an inhibitor of the tryptophan-synthase-inactivating enzymes in yeast. Eur. J. Biochem 32 (1973) 444-450.
Betz, H., Gratzl, M. and Remmer H. Inactivation of microsomal proteins by lysosomes. Hoppe-Seyler's Z. Physiol. Chem. 354 (1973) 567-575.
Betz, H. Inaktivierung mikrosomaler Reduktasen durch lysosomale Enzyme M.D. Thesis (1971) Universität Tübingen.
Betz, H. Halbwertszeiten mikrosomalen Proteins, gereinigter NADPH-abhängiger Cytochrom c-Reduktase sowie gereinigten Cytochroms b5 und deren Bedeutung für die Biogenese des endoplasmischen Retikulums. Diplomarbeit (1969) Universität Tübingen.

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