Source: https://userpages.umbc.edu/~hosmane/
Timestamp: 2019-04-24 02:08:05+00:00

Document:
(06) Eli Lilly & Co., Novel Compounds for Potential Medicinal & Agricultural Applications, 1986-1993.
(02) Project SEED, Am. Chem. Soc., Summer Educational Experience for the Disadvantaged, 1983-00.
Editorial Activities: Member, Editorial Board, Cancer Open Access, Managing Editor, Frontiers in Bioscience; Current Topics in Medicinal Chemistry; Regional Editor, Molecules.
Peer Reviewer: Grant Proposals: PRF, NIH, NSF, Am. Heart Assoc., Res. Corp., Guggenheim Foundation; Journals: JACS, JOC, Tet. Lett., J.Het.Chem., J. Med. Chem., Synthesis, Chem. Ber., Liebigs Ann. Chem., Nucleosides & Nucleotides, Nucl. Acids Res., J. Biomol.Struct. Dyn., Tetrahedron, Angewandte Chemie, Eur. J. Org. Chem., Hemoglobin, Bioorg. Med. Chem., Bioorg. Med. Chem. Lett.
Memberships: Sigma Xi; Affiliate IUPAC, Am. Chem. Soc., Chem. Soc.(London), Internat. Soc. Heterocycl. Chem., American Assoc. Adv. Science.
(A) "Fat" Nucleosides and Nucleotides as Potential Anticancer and Antiviral Agents:These novel ring-expanded ("fat") nucleoside/nucleotide analogues, designed and synthesized in this lab, have been found to be potent, broad-spectrum anticancer and antiviral agents with little, if any, toxicity to the host. Our current focus is on prostate and breast cancers, as well as on West Nile, Hepatits B, and Hepatitis C viruses. "Fat" nucleotides are potential modulators of tumor and/or viral DNA/RNA when incorporated, which may consequently result in nucleic acid chain termination ( Fig. 1), and hence inhibition of the viral or tumor replication. In addition, because of their unique structural, spatial, and conformational characteristics, "fat" nucleosides/-tides are excellent probes for nucleic acid metabolism, structure, and function.
(B) Artificial Blood for Emergency Transfusions: One of our research areas focuses on developing substitutes for human blood for emergency transfusions. In view of the current world events engulfed in terrorism and wars, the need for a blood substitute is becoming increasingly pressing. The scarcity of blood for emergency transfusions, especially when rare types are needed, the possible trans­mission of diseases associated with blood transfusion such as AIDS and hepatitis, the limitations on storage stability of intact blood, the necessity for blood typing before transfusion, and not to mention the ancillary religious reasons for non-acceptance of donated blood by certain ethnic individuals, give compelling impetus to pursue an alternative for whole blood. To this end, we are involved in computer-aided design and chemical synthesis of novel polyfunctional organic reagents to cross‑link hemoglobin (see Fig. 2). The modified cell-free hemoglobins are to be used in emergency transfusions with no necessity to type or cross-match the patient’s blood and with no fears of transmission of blood-borne diseases. The covalently cross-linked hemoglobins are supposed to overcome the two major problems associated with cell-free hemoglobins, including their quick elimination by kidneys, and their too high oxygen affinity that prevents adequate oxygen transport from lungs to tissues.
R. S. Hosmane, V. Raman, and R. Kumar, "Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof," US Patent# 8518901 B2, August 27, 2013.
R. S. Hosmane, V. Raman, and R. Kumar, "Fused Diimidazodiazepine Compounds as Antitumor Agents and Their Preparation, Pharmaceutical Compositions and Use in the Treatment of Cancers," World Patent# WO 2010039187 A2 20100408 , April 8, 2010.
R. S. Hosmane, R.K. Sood, "Ring-Expanded Nucleosides and Nucleotides," US Patent# 6677310 B1, January 13, 2004.
R. S. Hosmane, B. Burns, "Preparation of Ring-Expanded Nucleosides and Nucleotides as Virucides and Bactericides," US Patent# 5843912 A, December 1, 1998.
R. S. Hosmane, P. R. Rao, "Preparation of Acylsalicylates for Reducing the Mean Transit Time of Erythrocytes," US Patent# 5599959 A, February 4, 1997.
B. Burns, R.S. Hosmane "Preparation of ring-expanded bases, nucleosides and nucleotides as virucides, bactericides, fungicides, and parasiticides." World Patent# WO 9509175 A1 19950406 , April 6, 1995.
E. Bucci, C. Fronticelli-Bucci, R. S. Hosmane, "Preparation of Intramolecularly Cross-Linked Hemoglobin for Transfusion," US Patent# 4584130 A, April 22, 1986.
M. Xie, R. G. Lapidus, M. Sadowska, M. J. Edelman, and R. S. Hosmane, "Synthesis, anticancer activity, and SAR analyses of compounds containing the 5:7-fused 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system," Bioorg. Med. Chem. 2016, 24, 2595-2602.
M. Xie, F. Vesuna, M. Botlagunta, G. M. Bol, A. Irving, R. S. Hosmane, Y. Kato, P. T. Winnard, Jr., V. Raman, "NZ51, A Ring-Expanded Nucleoside Analog, Exhibits Anticancer Activity by Targeting the RNA Helicase DDX3," Oncotarget, 2015, 6 29901-29913.
G. M. Bol, F. Vesuna, M. Xie, J. Zeng, K. Aziz, N. Gandhi, A. Levine, A. Irving, D. Korz, S. Tantravedi, M. R. H. van Voss, K. Gabrielson, E. A. Bordt, B. M. Polster, L. Cope, P. van der Groep, A. Kondaskar, M. A. Rudek, R. S. Hosmane, E. van der Wall, P. J. van Diest, P. T. Tran, V. Raman, "Targeting DDX3 by a Small Molecule Inhibitor for Lung Cancer Therapy," EMBO Mol. Med., 2015, 7, 648-669.
N. Zhang, P. Zhang, A. Baier, L. Cova, and R. S. Hosmane, "Dual Inhibition of HCV and HIV by Ring-Expanded Nucleosides Containing the 5:7-Fused Imidazo[4,5-e][1,3]diazepine Ring System. In Vitro Results and Implications," Bioorg. Med. Chem. Lett. 2014, 24, 1154-1157.
S. Tantravedi, S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively Substituted Imidazo[4,5-e][1,4]diazepines ," Bioorg. Med. Chem. 2013, 21, 4893-4903.
A. Kondaskar, S. Kondaskar, J. C. Fishbein, B. A. Carter-Cooper, R. G. Lapidus, M. Sadowska, M. J. Edelman, and R. S. Hosmane, "Structure-based Drug Design and Potent Anti-cancer Activity of Tricyclic 5:7:5-Fused Diimidazo[4,5-d:4',5'-f][1,3]diazepines," Bioorg. Med. Chem. 2013, 21, 618-631.
S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "Investigations into Specificity of Azepinomycin for Inhibition of Guanase: Discrimination between the Natural Heterocyclic Inhibitor and Its Synthetic Nucleoside Analogues," Bioorg. Med. Chem. Lett. 2012, 22, 7214-7218.
S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "A Novel Transition State Analogue Inhibitor of Guanase Based on Azepinomycin Ring Structure: Synthesis and Biochemical Assessment of Enzyme Inhibition," Bioorg. Med. Chem. Lett. 2011, 21, 756-759.
A. Kondaskar, S. Kondaskar, R. Kumar, N. Muvarak, R. G. Lapidus, M. Sadowska, M. J. Edelman, G. M. Bol, F. Vesuna, V. Raman, and R. S. Hosmane, "Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System," ACS Med. Chem. Lett. 2011, 2, 252-256.
H. Cai, T. A. Roach, M. Dabek, K. S. Somerville, S. Acharya, and R. S. Hosmane, "Bis[2-(3-carboxyphenoxy)carbonylethyl]phosphinic Acid (m-BCCEP): A Novel Affinity Cross-Linking Reagent for the b-Cleft Modification of Hemoglobin," Bioconj. Chem. 2010, 21, 1494-1507.
M. Xie, R. K. Ujjinamatada, M. Sadowska, R. G. Lapidus, M. J. Edelman, and R. S. Hosmane, "A Novel, Broad-Spectrum Anticancer Compound Containing the Imidazo[4,5-e][1,3]diazepine Ring System," Bioorg. Med. Chem. Lett. 2010, 20, 4386-4389.
K. Watashi, M. L. Yeung, M. F. Starost, R. S. Hosmane, and K. -T. Jeang, "Identification of Small Molecules that Suppress Micro RNA Function and Reverse Tumorigenesis," J. Biol. Chem. 2010, 285, 24707-24716.
R. S. Hosmane and J. F. Liebman, "Paradoxes and Paradigms: Why is Quinoline Less Basic than Pyridine or Isoquinoline? A Classical Organic Chemical Perspective,” Struct. Chem. 2009, 20, 693-697.
R. S. Hosmane, "Ring-Expanded ("Fat") Purines and Their Nucleoside/Nucleotide Analogues as Broad-Spectrum Therapeutics, ” Progr. Heterocycl. Chem. 2009, 21, 35-68.
R. Kumar, R. K. Ujjinamatada, and R. S. Hosmane ” The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties, ” Org. Lett. 2008, 10, 4681-4684.
V. S. R. K. Yedavalli, N. Zhang, P. Zhang, H. Cai, M. F. Starost, R. S. Hosmane, and K-T. Jeang, ” Ring-Expanded (REN) Nucleoside Analogues Inhibit RNA Helicase and Intracellular HIV-1 Replication, ” J. Med. Chem. 2008, 51, 5043-5051.
R. K. Ujjinamatada, P. Phatak, A. M. Burger, and R. S. Hosmane, “Inhibition of adenosine deaminase by analogues of adenosine and inosine incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one,” J. Med. Chem. 2008, 51, 694-698.
P. Zhang, N. Zhang, V. Buckwold, R. S. Hosmane, “Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity,” Bioorg. Med. Chem., 2007, 15, 4933-4945.
R. K. Ujjinamatada, A. Baier, P. Borowski, and R. S. Hosmane, “An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5- (4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside,” Bioorg. Med. Chem. Lett. 2007, 17, 2285-2288.
P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Structure-activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system,” Bioorg. Med. Chem. Lett. 2007, 17, 2225-2228.
R. K. Ujjinamatada, A. Bhan, and R. S. Hosmane, "Design of Inhibitors Against Guanase: Synthesis and Biochemical Evaluation of Analogues of Azepinomycin," Bioorg. Med. Chem. Lett. 2006, 16, 5551-5554.
R. K. Ujjinamatada, R.L. Paulman, R. G. Ptak, and R. S. Hosmane, "Nucleosides with Self-Complementary Hydrogen-Bonding Motifs: Synthesis and Base-Pairing Studies of Two Nucleosides Containing the Imidazo[4,5-d]pyridazine Ring System," Bioorg. Med. Chem. 2006, 14, 6359-6367.
P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Synthesis and In Vitro Anti-Hepatitis B and C Virus Activities of Ring-Expanded ("Fat") Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine-4,8-dione Ring System,” Bioorg. Med. Chem. Lett. 2005, 15, 5397-5401.
R. K. Ujjinamatada and R. S. Hosmane, “Selective Functional Group Transformation Using Guanidne: The Conversion of an Ester Group into an Amide in Vinylogous Ester-Aldehydes,” Tetrahedron Lett. 2005, 46, 6005-6009.
R. K. Ujjinamatada, Y. S. Agasimundin, P. Zhang, V. Koch, H. Schmitz, P. Borowski, K. Kalicharran, A. Fattom, and R. S. Hosmane, “A Novel Imidazole Nucleoside Containing a Diaminodihydro-s-Triazine as a Substituent and an Inhibitory Activity against the West Nile Virus NTPase/Helicase,” Nucleosides Nucleotides Nucleic Acids 2005, 24, 1775-1788.
Ujjinamatada, R. K., Agasimundin, Y. S., Borowski, P., and Hosmane, R. S., “ Reactions of Guanidine with Vinylogous Ester-Aldehydes: Synthesis and Anti-West Nile Virus Activity of a Novel Imidazole Nucleoside Containing a Diaminodihydro-s-triazine as a Substituent,” Antiviral Res. 2005, 65, A68-A69.
T. A. Roach, V. W. Macdonald, and R. S. Hosmane, “A Novel Site-Directed Affinity Reagent for Cross-Linking Human Hemoglobin: Bis[2-(4-phosphonooxy phenoxy)carbonylethyl]phosphinic Acid (BPPCEP)” J. Med. Chem., 2004, 47, 5847-5859.
S. Gunther, M. Asper, C. Roser, L.K.S. Luna, C. Drosten, B. Becker-Ziaza, P. Borowski, and R. S. Hosmane, "Applications of Real-Time PCR for Testing Antivial Compounds Against Lassa Virus, SARS CoronaVirus, and Ebola Virus In Vitro," Antiviral Res. 2004, 63, 209-215.
A. Reayi and R. S. Hosmane, “Inhibition of Adenosine Deaminase by Novel 5:7-Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure-Activity Relationship Study,” J. Med. Chem. 2004, 47, 1044-1050.
A. Reayi and R. S. Hosmane, "Inhibitors of Adenosine Deaminase: Continued Studies of Structure-Activity Relationships in Analogues of Coformycin," Nucleosides Nucleotides Nucleic Acids 2004, 23, 263-270.
R. S. Hosmane and J. F. Liebman, “Resonance Stabilization in Diazophenoxides,” Struct. Chem. 2004, 15, 253-255.
N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, M. Bretner, V. S. Bhadti, A. I. Fattom, R. B. Naso, R. S. Hosmane, and P. Borowski, "Ring-Expanded Nucleoside and Nucleotide (REN) Analogues Exhibit Potent In Vitro Activity Against Flaviviridae NTPases/Helicases, including Those of the West Nile Virus (WNV), Hepatitis C Virus (HCV), and Japanese Encephalitis Virus (JEV)," J. Med. Chem. 2003, 46, 4149-4164.
N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, A. I. Fattom, R. B. Naso, K. Kalicharran, P. Borowski, and R. S. Hosmane, "Potent inhibition of NTPase/helicase of the West Nile Virus by Ring-Expanded Nucleoside (REN) Analogues," J. Med. Chem. 2003, 46, 4776 - 4789.
Borowski, P., zur Wiesch, J. C. R. S., Schmitz, H., and Hosmane, R. S., “Inhibition of HCV NTPase/Helicase by Ring-Expanded Nucleosides (RENs),” Hepatology 2003, 38,624A-625A.
F. N. Burnett and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded Purine Analogue Containing a 5:8-Fused Imidazo[4,5-e][1,2,4]triazocine Ring System Amidst Opportunistic Rearrangements and Ring Transformations," Tetrahedron 2002, 58, 9567-9578.
N. Zhang, H. -M. Chen, R. Sood, K. Kalicharran, A. I. Fattom, R. B. Naso, D. L. Barnard, R. W. Sidwell, and R. S. Hosmane, "In Vitro Inhibition of Measles Virus Replication by Novel Ring-Expanded (“Fat”) Nucleoside Analogues Containing the Imidazo[4,5-e][1,3]diazepine Ring System, Bioorg. Med. Chem. Lett. 2002, 12, 3391-3394.
R. Hosmane, "Ring-Expanded ("Fat") Nucleosides as Broad-Spectrum Anticancer and Antiviral Agents," in "Current Topics in Medicinal Chemistry: Recent Developments in Antiviral Nucleosides, Nucleotides, and Oligonucleotides," Hosmane, R. S., Ed., Bentham Science Publishers, 2002, Vol. 2, pp. 1093-1109.
R. Hosmane, "Coformycin and Analogues as Inhibitors of Adenosine Deaminase," in "Modified Nucleosides, Synthesis, and Applications," Loakes, D, Ed., Transworld Research Network, Trivendrum, 2002; pp.133-151.
P. Borowski, M. Lang, A. Haag, H. Schmitz, J. Choe, H. -M. Chen, and R. S. Hosmane, "Characterization of Imidazo[4,5-d]pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus NTPase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme," Antimicrob. Agents Chemotherap. 2002, 46, 1231-1239.
R. K. Sood, V. S. Bhadti, A. I. Fattom, R. B. Naso, H. Chen, B. E. Korba, E. Kern, and R. S. Hosmane, "Novel Ring-Expanded Nucleoside Analogs Exhibit Potent and Selective Inhibition of Hepatitis B Virus Replication in Cultured Human Hepatoblastoma Cells," Antiviral Res., 2002,53, 159-164.
P. Borowski, A. Niebuhr, H. Schmitz, R. S. Hosmane, M. Bretner, M. A. Siwecka, and T. Kulikowski, "NTPase/Helicase of Flaviviridae: Inhibitors and Inhibition of the Enzyme," Acta Biochem. Polon. 2002, 49, 597-614.
M. V. Roux, M. Temprado, J. Z. Dávalos, P. Jiménez, R. S. Hosmane, and J. F. Liebman, "Enthalpy of Formation of Methyl Benzoate: Calorimetry and Consequences," Phys. Chem. Chem. Phys. 2002, 4, 3611-3613.
R. S. Hosmane and J. F. Liebman, "Diazomethane and Ethyl Diazoacetate: The Role of Substituent Effects on Stability," Struct. Chem. 2002, 5-6, 501-503.
H. -M. Chen and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded ("Fat") Nucleotide Analogue of Phosphonomethoxyethylguanine (PMEG) Containing the Imidazo[4,5-e][1,3]diazepine Ring System," J. Heterocycl. Chem. 2001, 38, 1313-1315.
L. Wang and R. S. Hosmane, "A Unique Ring-Expanded Acyclic Nucleoside Analogue That Inhibits Both Adenosine Deaminase (ADA) and Guanine Deaminase (GDA; Guanase): Synthesis and Enzyme Inhibition Studies of 4,6-Diamino-8-H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine, " Bioorg. Med. Chem. Lett. 2001, 11, 2893-2896.
H. -M. Chen and R. S. Hosmane, "Synthesis of 1-(2'-O-Methyl-ß-D-ribo- furanosyl)-1H-imidazo[4,5-d]- pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications," Molecules 2001, 6, 203-207.
J. Gill, M. Bretner, R. Newman, N. Kyprianou, and R. S. Hosmane, "Synthesis, Anticancer Activity, and In Vitro Mechanistic Investigations of Several "Fat" Nucleosides Containing the Imidazo[4,5-e][1,3] diazepine Ring System," Nucleosides & Nucleotides 2001, 20, 1043-1045.
H. -M. Chen and R. S. Hosmane, "Acyclic Nucleoside/Nucleotide Analogues Bearing an Imidazole Ring Skeleton," Nucleosides & Nucleotides 2001, 20, 1599-1614.
Z. Sun and R. S. Hosmane, "An Improved Synthesis of 9-Benzyladenine: A Model for Adenosine and Its Analogues," Synth. Commun. 2001, 32, 549-554.
R. K. Sood, V. S. Bhadti, H. -M. Chen, and R. S. Hosmane, "6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione," Molecules2001, 6, M264.
H. -M. Chen and R. S. Hosmane, "Synthesis of 1-(2'-Deoxy-ß-D-ribo- furanosyl)-1H-imidazo [4,5-d]- pyridazine-4,7(5H,6H)-dione: a Potentially Useful Building Block for Antisense Applications," Molecules 2000, 5, 1187-1193.
H. -M. Chen and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded Nucleoside Analogue Containing the Imidazo[4,5-e][1,3]diazepine Ring System With a Guanidinocarbamoyl- Substituted Cyclopropylidene Group in Place of a Sugar Moiety," J. Heterocyclic Chem. 2000, 37, 951-953.
S. Siddiqui and R. S. Hosmane, "Synthetic Analogues of Stilbene Containing an Imidazole Nucleus," Molecules 2000, 5, 856-863.
H. -M. Chen and R. S. Hosmane, "Synthesis of 6-Amino-2-phenylimidazo [4,5-e][1,3]diazepine-4,8(1H, 5H)-dione," Molecules 2000, 5, M164.
V. Rajappan and R. S. Hosmane, "A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines," Tetrahedron Lett. 2000, 41, 9713-9717.
Z. Sun and R. S. Hosmane, "Photochromic Fulgides: Transformation of the Non-photochromic (Z)-Isomer of a Fulgide into a Highly Photochromic (E)-Isomer via Structural Modification Involving Enhanced Conjugation," J. Heterocyclic Chem. 2000, 37, 1439-1441.
S. P. Peri, V. S. Bhadti, R. Liang, R. S. Hosmane, and V. W. Macdonald, "Affinity Reagents for Cross-Linking Hemoglobin: Bis(phenoxycarbonylethyl) phosphinic Acid (BPCEP) and Bis(3-nitrophenoxycarbonylethyl)phosphinic Acid (BNCEP)," Hemoglobin1999, 23, 1-20.
H. Chen, R. Sood, and R. S. Hosmane, "An Efficient, Short Synthesis of 6-Imino-6-H-1-ß-D-ribofuranosyl-4,5,7,8-tetrahydroimidazo[4,5-e]diazepine- 4,8-dione: A Novel Ring-Expanded Purine Nucleoside Analogue Containing a 5:7-Fused, Planar, Aromatic, Heterocyclic Ring System," Nucleosides & Nucleotides 1999, 18, 331-335.
M. Bretner, D. Beckett, R. Sood, and R. S. Hosmane, "Substrate/Inhibition of Bacteriophage T7 RNA Polymerase by the 5'-Triphosphate Derivative of a Ring-Expanded ("Fat") Nucleoside Possessing a Potent Anti-Hepatitis B Viral Activity," Bioorg. Med. Chem. 1999, 7, 2931-2936.
V. Rajappan and R. S. Hosmane, "Investigations into Biochemical Mode of Inhibition of Guanase by Azepinomycin: Synthesis and Biochemical Screening of Several Analogues of Azepinomycin," Nucleosides & Nucleotides 1999, 18, 835-836.
M. Bretner, D. Beckett, and R. S. Hosmane, "Potent Anti-Hepatitis B Viral Activity and Inhibition of Bacteriophage T7 RNA Polymerase by a ‘Fat" Nucleoside and Its 5'-Triphosphate Derivative: Synthetic, Biochemical, and Biological Studies of 4,8-Diamino-6-imino-6H-1-ß-D-ribofuranosyl- imidazo[4,5-e][1,3] diazepine-5'-triphosphate," Nucleosides & Nucleotides1999, 18, 837-838.
J. Z. Dávalos, H. Flores, P. Jiménez, R. Notario, M. V. Roux, E. Juaristi, R. S. Hosmane, and J. F. Liebman, "Calorimetric, Calculational (G2(MP2) and G3) and Conceptual Study of the Energetics of the Isomeric 1,3- and 1,4-Dithianes," J. Org. Chem. 1999, 64, 9328-9336.
Y. S. Agasimundin, M. W. Mumper, and R. S. Hosmane, "Inhibitors of Glycogen Phosphorylase B: Synthesis, Biochemical Screening, and Molecular Modeling Studies of Novel Analogues of Hydantocidin," Bioorg. Med. Chem. 1998, 6, 911-923.
V. P. Rajappan and R. S. Hosmane, "Analogues of Azepinomcin as Inhibitors of Guanase," Nucleosides & Nucleotides 1998, 17, 1141-1151.
V. P. Rajappan and R. S. Hosmane, "Synthesis and Guanase Inhibition Studies of a Novel Ring-Expanded Purine Analogue Containing a 5:7-Fused, planar, Aromatic Heterocyclic Ring System," Bioorg. Med. Chem. Lett. 1998, 8, 3649-3652.
V. P. Rajappan and R. S. Hosmane, "Pentafluorophenol: A Superior Reagent for Condensations in Heterocyclic Chemistry," Synth. Commun. 1998, 28, 753-764.
R. S. Hosmane, S. P. Peri, V. S. Bhadti, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl- ethyl]phosphinic Acid (BCCEP): A Novel Affinity Reagent for the b-Cleft Modification of Human Hemoglobin," Bioorg. Med. Chem.1998, 6, 767-783.
R. S. Hosmane and M. Hong, "How Important Is the N-3 Sugar Moiety in the Tight-Binding Interaction of Coformycin with Adenosine Deaminase?" Biochem. Biophys. Res. Commun. 1997, 236, 88-93.
F. N. Burnett and R. S. Hosmane, "Imidazo[4,5-e][1,2,4]triazocine: A Novel 5:8-Fused Ring System Riddled with Rearrangements," Heterocycles 1997,45, 857-861.
M. V. Roux, P. Jimênez, M. À. Martín-Luengo, J. Z. Dàvalos, Z. Sun, R. S. Hosmane, J. F. Liebman, "The Elusive Antiaromaticity of Maleimides and Maleic Anhydride: Enthalpies of Formation of N-Methylmaleimide, N-Methylsuccinimide, N-Methylphthalimide and N-Benzoyl-N-methyl- benzamide," J. Org. Chem. 1997, 62, 2732-2737.
M. Hong and R. S. Hosmane, "Irreversible, Tight-Binding Inhibition of Adenosine Deaminase by Coformycins: Inhibitor Structural Features that Contribute to the Mode of Inhibition, " Nucleosides and Nucleotides1997, 16, 1053-1057.
S. P. Peri, V. S. Bhadti, R. S. Hosmane, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl- ethyl)phosphinic Acid (BCCEP): A New Reagent for Hemoglobin Modification," Artif. Cells Blood Subst. Immobil. Biotech. 1997, 25, 511-520.

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