Source: https://profiles.bu.edu/Ji.Yi
Timestamp: 2019-04-22 02:54:27+00:00

Document:
Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.
Song W, Zhou L, Yi J. Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT). J Vis Exp. 2018 08 04; (138). PMID: 30124648.
Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 Nov; 11(11):e201800053.View Related Profiles.
Song W, Zhou L, Zhang S, Ness S, Desai M, Yi J. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina. Biomed Opt Express. 2018 Jul 01; 9(7):3464-3480.View Related Profiles.
Zhang L, Song W, Shao D, Zhang S, Desai M, Ness S, Roy S, Yi J. Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO). Biomed Opt Express. 2018 01 01; 9(1):25-40.View Related Profiles.
Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 08 17; 7(1):8591.View Related Profiles.
Song W, Zhang L, Ness S, Yi J. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching: a numerical study. Biomed Opt Express. 2017 Sep 01; 8(9):3966-3980.View Related Profiles.
Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26.View Related Profiles.
PMID: 26636933; PMCID: PMC4675813; DOI: 10.1016/j.bpj.2015.10.014;.
Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015; 6:8094. PMID: 26348915; PMCID: PMC4563812; DOI: 10.1038/ncomms9094;.
Liu W, Yi J, Chen S, Jiao S, Zhang HF. Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length. Med Phys. 2015 Sep; 42(9):5356-62. PMID: 26328984; PMCID: PMC4545096; DOI: 10.1118/1.4928597;.
Chen S, Yi J, Zhang HF. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography. Biomed Opt Express. 2015 Aug 1; 6(8):2840-53. PMID: 26309748; PMCID: PMC4541512; DOI: 10.1364/BOE.6.002840;.
Urban BE, Yi J, Chen S, Dong B, Zhu Y, DeVries SH, Backman V, Zhang HF. Super-resolution two-photon microscopy via scanning patterned illumination. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Apr; 91(4):042703. PMID: 25974523; PMCID: PMC4565794.
Chen H, Zhao Y, Liu M, Feng L, Puyang Z, Yi J, Liang P, Zhang HF, Cang J, Troy JB, Liu X. Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1971-84. PMID: 25722210; PMCID: PMC4365983; DOI: 10.1167/iovs.14-15691;.
Chen S, Yi J, Dong B, Sun C, Kiser PF, Hope TJ, Zhang HF. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography. Quant Imaging Med Surg. 2015 Feb; 5(1):40-5. PMID: 25694952; PMCID: PMC4312293; DOI: 10.3978/j.issn.2223-4292.2014.11.03;.
Song W, Wei Q, Liu W, Liu T, Yi J, Sheibani N, Fawzi AA, Linsenmeier RA, Jiao S, Zhang HF. A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography. Sci Rep. 2014; 4:6525. PMID: 25283870; PMCID: PMC4185377; DOI: 10.1038/srep06525;.
Yi J, Chen S, Backman V, Zhang HF. In vivo functional microangiography by visible-light optical coherence tomography. Biomed Opt Express. 2014 Oct 1; 5(10):3603-12. PMID: 25360376; PMCID: PMC4206328; DOI: 10.1364/BOE.5.003603;.
Urban BE, Yi J, Yakovlev V, Zhang HF. Investigating femtosecond-laser-induced two-photon photoacoustic generation. J Biomed Opt. 2014 Aug; 19(8):085001. PMID: 25084119; PMCID: PMC4118047; DOI: 10.1117/1.JBO.19.8.085001;.
Yi J, Radosevich AJ, Stypula-Cyrus Y, Mutyal NN, Azarin SM, Horcher E, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography. J Biomed Opt. 2014 Mar; 19(3):36013.View Related Profiles.
PMID: 24643530; PMCID: PMC4019430; DOI: 10.1117/1.JBO.19.3.036013;.
Rogers JD, Radosevich AJ, Yi J, Backman V. Modeling Light Scattering in Tissue as Continuous Random Media Using a Versatile Refractive Index Correlation Function. IEEE J Sel Top Quantum Electron. 2013 Sep 06; 20(2):7000514. PMID: 25587211.
Radosevich AJ, Mutyal NN, Yi J, Stypula-Cyrus Y, Rogers JD, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy. J Biomed Opt. 2013 Sep; 18(9):097002.View Related Profiles.
PMID: 24008865; PMCID: PMC3764252; DOI: 10.1117/1.JBO.18.9.097002;.
Black KC, Sileika TS, Yi J, Zhang R, Rivera JG, Messersmith PB. Bacterial killing by light-triggered release of silver from biomimetic metal nanorods. Small. 2014 Jan 15; 10(1):169-78. PMID: 23847147; PMCID: PMC4065421; DOI: 10.1002/smll.201301283;.
Yi J, Wei Q, Liu W, Backman V, Zhang HF. Visible-light optical coherence tomography for retinal oximetry. Opt Lett. 2013 Jun 1; 38(11):1796-8. PMID: 23722747; PMCID: PMC3986589.
Yi J, Radosevich AJ, Rogers JD, Norris SC, Çapoglu IR, Taflove A, Backman V. Can OCT be sensitive to nanoscale structural alterations in biological tissue? Opt Express. 2013 Apr 8; 21(7):9043-59. PMID: 23571994; PMCID: PMC3641881.
Liu W, Liu T, Song W, Yi J, Zhang HF. Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography. J Biomed Opt. 2013 Jan; 18(1):16002. PMID: 23292611; PMCID: PMC3537324; DOI: 10.1117/1.JBO.18.1.016002;.
Radosevich AJ, Yi J, Rogers JD, Backman V. Structural length-scale sensitivities of reflectance measurements in continuous random media under the Born approximation. Opt Lett. 2012 Dec 15; 37(24):5220-2. PMID: 23258058; PMCID: PMC3655697.
Yi J, Backman V. Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography. Opt Lett. 2012 Nov 1; 37(21):4443-5. PMID: 23114323; PMCID: PMC3640644.
Black KC, Yi J, Rivera JG, Zelasko-Leon DC, Messersmith PB. Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy. Nanomedicine (Lond). 2013 Jan; 8(1):17-28. PMID: 22891865; PMCID: PMC3530415; DOI: 10.2217/nnm.12.82;.
Yi J, Wei Q, Zhang HF, Backman V. Structured interference optical coherence tomography. Opt Lett. 2012 Aug 1; 37(15):3048-50. PMID: 22859081; PMCID: PMC3544536.
Radosevich AJ, Rogers JD, Turzhitsky V, Mutyal NN, Yi J, Roy HK, Backman V. Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales. IEEE J Sel Top Quantum Electron. 2012 Jul; 18(4):1313-1325.View Related Profiles.
Radosevich AJ, Mutyal NN, Turzhitsky V, Rogers JD, Yi J, Taflove A, Backman V. Measurement of the spatial backscattering impulse-response at short length scales with polarized enhanced backscattering. Opt Lett. 2011 Dec 15; 36(24):4737-9. PMID: 22179867; PMCID: PMC3355761.
Yi J, Li X. Estimation of oxygen saturation from erythrocytes by high-resolution spectroscopic optical coherence tomography. Opt Lett. 2010 Jun 15; 35(12):2094-6. PMID: 20548397.
Yi J, Gong J, Li X. Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography. Opt Express. 2009 Jul 20; 17(15):13157-67. PMID: 19654721.
Gong J, Yi J, Turzhitsky VM, Muro K, Li X. Characterization of malignant brain tumor using elastic light scattering spectroscopy. Dis Markers. 2008; 25(6):303-12. PMID: 19208948; PMCID: PMC3827811.

References: V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V.