Source: http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1330
Timestamp: 2019-04-25 18:10:03+00:00

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Department of Pharmacy, University Science and Technology Chittagong, Bangladesh.
Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh.
Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh.
A suitable matrix system of ketorolac tromethamine (KTR) formulation has been developed with the aim of increasing the contact time, achieving controlled release, reducing the frequency of administration, improving patient compliance. In this concern an enteric-coated KTR matrix tablet intended for specific delivery of drugs to the colon by combining the use of a time dependent core with a pH-sensitive film coating. Eudragit L100, with a threshold pH 7, was selected as coating material. New formulation is proved to be noble as to KTR delivery through both gastrointestinal and colonic system. New formulation is considered to reduce gastrointestinal side effects and achieve high local drug concentration at the afflicted site in the gastro-intestine and colon.
Andrade, J.R.; Maslanka, M.; Maneatis, T.; Bynum, L.; Burchomore, M. 1994. The use of ketorolac tromethamine in the management of post operative pain. Orthopedics, v. 17, p. 157–166.
Asghar, L.F.; Chure, C.B.; Chandran, S. 2009. Colon specific delivery of indomethacin: effect of incorporating ph sensitive polymers in xanthan gum matrix bases. AAPS Pharm Sci Tech., v. 10(2), p. 418-429.
Chopra, D.; Sinha, V.R.; Singh, M. 2008. Thermal and isothermal methods in development of sustained release dosage forms of ketorolac tromethamine. E-J Chem., v. 5(2), p. 316-322.
Chourasia, M.K.; Jain, S.K. 2003. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharmaceut Sci., v. 6(1), p. 33-66.
Demiroz, F.T.; Acarturk, F.; Takka, S.; Boyunaga, O.K. 2004. In-vitro and In-vivo Evaluation of Mesalazine–Guar Gum Matrix Tablets for Colonic Drug Delivery. J Drug Targ, v. 12(2), p. 105–112.
Girish, N.P.; Gayatri, C.P.; Ritesh, B.P. 2006. Oral colon-specific drug delivery: an overview. Drug Delivery Tech., v. 6(7), p. 62-71.
Krishnaiah, Y.S.R.; Satyanarayana, S.; Ramaprasad, Y.V.; Narasimharao, S. 1998. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm., v. 171, p. 137-146.
Mathews, B.R. 1999. Regulatory aspects of stability testing in Europe. Drug Dev Ind Pharm., v. 25, p. 831-856.
Mundargi, R.C.; Patil, S.A.; Agnihotri, S.A.; Aminabhavi, T.M. 2007. Development of polysaccharide-based colon targeted drug delivery systems for the treatment of amoebiasis. Drug Dev Ind Pharm., v. 33, p. 255–264.
Robinson, J. R.; Lee, V. H. 1987. “Transdermal Therapeutic Systems” Charpter–12. in “ Control drug delivery,” 2nd edition V 29, p 523-531.
Shankar, C.; Mishra M. 2003. Development and in-vitro evaluation of gelatin A microspheres of ketorolac tromethamine for intranasal administration. Acta Pharm., v. 53, p. 101–110.
aShyamala, B.; SANMATHI, B.S. 2001. Poly(lactic acid) microspheres of ketorolac tromethamine for parenteral controlled drug delivery system. Indian J Pharm Sci., v. 63, p. 538–540.
bshyamala, B.; Sanmathi, B.S. 2001. Innfluence of manufacturing parameters and the release profile of Ketorolac tromethamine from poly (Lactide-co-glycolide) microspheres. Indian Drugs, v. 38, p. 383–385.
Staniforth, J.N.; Aulton, M.E. Powder flow. In Aulton M. E. (Ed.) 2007. Aulton’s Pharmaceutics-The Design and Manufacture of Medicines. Churchill Livingstone: Elsevier, Inc. p. 168-179.
Uddin, M.N; Das, S.; Khan, S. H.; Shill, S. K.; Bhuiyan, H. R.; Karim, R. 2014. A novel validated UPLC method for the estimation of ketorolac tromethamine in pharmaceutical formulation. Research v. 1, p. 1237.
Valluru, R.; Siddaramaiah, T.; Pramod, M. 2008. Influence of natural polymer coating on novel colon targeting drug delivery system. J Mater Sci., v. 19, p. 2131–2136.
Vemula, S.K.; Veerareddy, P.R. 2009. Different approaches to design and evaluation of colon specific drug delivery systems. Int J Pharm Tech., v. 1(1), p. 1-35.
Vincent, H. L.; Suman, K. M. 2002. Drug delivery-oral colon-specific. In J. Swarbick and C. J. Boylan. (Ed.) Encyclopedia of Pharm Tech. New York: Marcel Dekker, Inc. p. 871-885.
Vyas, S.P.; Roop, K.K. 2006. Controlled drug delivery concepts and advances. 1st ed. Vallabh Prakashan Publishers, Delhi p. 218-256.
Wu, B.; Shun, N.; Wei, X.; Lu, Y.; Wu, W. 2007. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: I. Characterization and mechanistic study. Eur J Pharm Biopharm., v. 67, p. 707–714.

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