Source: http://elib.grsmu.by/handle/files/790
Timestamp: 2019-04-19 14:53:44+00:00

Document:
Khrustalev, V. V.; Lelevich, S. V.; Barkovsky, E. V.
Khrustalev, V. V. Zebra Finch Glucokinase Containing Two Homologous Halves Is an In Silico Chimera / V. V. Khrustalev, S. V. Lelevich, E. V. Barkovsky // ISRN Computational Biology. – 2013. – Vol. 2013. – Р. 1-6.
Chimerical nature of the gene annotated as Zebra finch (Taeniopygia guttata) glucokinase (hexokinase IV) has been proved in this study. N-half of the protein encoded by that gene shows similarity with glucokinase from other vertebrates, while its C-half shows similarity with C-halves of hexokinases II. We mapped 7 new exons coding for N-half of hexokinase II and 4 new exons coding for glucokinase of Zebra finch. Finally, we reconstructed normal genes coding for Zebra finch glucokinase and hexokinase II which are situated in "head-to-tail" orientation on the chromosome 22. Because of the error in gene annotation, exons encoding N-half of normal glucokinase have been fused with exons encoding C-half of normal hexokinase II, even though they are separated from each other by the sequence 98066 nucleotides in length.

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