Source: https://journal.niidi.ru/jofin/article/view/17
Timestamp: 2019-04-24 16:24:02+00:00

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Функциональные исследования выявили важное значение структурной целостности компонентов внутриклеточной сигнальной трансдукции системы врожденного иммунитета. Идентифицирована молекулярная структура ряда протеинов, участвующих в иммунном сигналинге, что способствует пониманию механизмов функционирования врожденного иммунитета на молекулярном уровне. Полиморфизмы, изменяющие сигнальную трансдукцию в клеточных элементах врожденного иммунитета и влияющие на предрасположенность человека к различным инфекциям, являются еще одним доказательством роли генетического фона хозяина в патофизиологии инфекционных заболеваний или резистентности к ним. В лекции описаны полиморфизмы молекул, вовлеченных в иммуногенный сигналинг, которые ассоциированы с продукцией провоспалительных цитокинов и эффективностью иммунных реакций.
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