Source: https://cnin-naturopatia.eu/
Timestamp: 2019-04-24 13:51:57+00:00

Document:
Describen los costos asociados con los Servicios Profesionales de Naturopatía y evalúan la eficacia económica de la práctica profesional Naturopática. Todavía hay pocos estudios publicados sobre costos de la práctica profesional Naturopática. Algunos estudios más se han realizado sobre la atención complementaria y alternativa en general; las publicaciones enumeradas aquí contienen al menos una parte de los datos notificados específicamente sobre la atención Naturopática.
Deborah A. Kennedy, Jason Hart, and Dugald Seely. Cost Effectiveness of Natural Health Products: A Systematic Review of Randomized Clinical Trials. Evidence-Based Complementary and Alternative Medicine Volume 6 (2009), Issue 3, Pages 297-304.
Herman PM, Szczurko O, Cooley K, Mills EJ.. Cost-effectiveness of naturopathic care for chronic low back pain. Altern Ther Health Med. 2008 Mar-Apr;14(2):32-9.
Herman PM, Szczurko O, Cooley K, Seely D.. A naturopathic approach to the prevention of cardiovascular disease: cost-effectiveness analysis of a pragmatic multi-worksite randomized clinical trial. J Occup Environ Med. 2014 Feb;56(2):171-6.
Lafferty WE, Bellas A, Corage Baden A, Tyree PT, Standish LJ, Patterson R. The use of complementary and alternative medical providers by insured cancer patients in Washington State. Cancer. 2004 Apr 1;100(7):1522-30.
Lafferty WE, Tyree PT, Bellas AS, Watts CA, Lind BK, Sherman KJ, Cherkin DC, Grembowski DE. Insurance coverage and subsequent utilization of complementary and alternative medicine providers. Am J Manag Care. 2006 Jul;12(7):397-404.
Lind BK, Lafferty WE, Tyree PT, Diehr PK, Grembowski DE. Use of complementary and alternative medicine providers by fibromyalgia patients under insurance coverage. Arthritis Rheum. 2007 Feb 15;57(1):71-6.
Tripathy JP. Can naturopathy provide answers to the escalating health care costs in India?. J Tradit Complement Med. 2015 Jan 16;5(2):63-5.
Wiesenauer M, Groh P, Häussler S. Naturopathy as a contribution to cost control. Attempt at a cost analysis. Fortschritte der Medizin [1992, 110(17):311-314].
1. Cavallito, C. J., & Bailey, J. H. (1944). Allicin, the antibacterial principle of Allium sativum. I. Isolation, physical properties and antibacterial action.Journal of the American Chemical Society, 66(11), 1950-1951.
2. Cavallito, C. J., Buck, J. S., & Suter, C. M. (1944). Allicin, the antibacterial principle of Allium sativum. II. Determination of the chemical structure. Journal of the American Chemical Society,66(11), 1952-1954.
Weisberger, A. S., & Pensky, J. (1958). Tumor inhibition by a sulfhydryl-blocking agent related to an active principle of garlic (Allium sativum). Cancer research, 18(11), 1301-1308.
Barone, F. E., & Tansey, M. R. (1977). Isolation, purification, identification, synthesis, and kinetics of activity of the anticandidal component of Allium sativum, and a hypothesis for its mode of action. Mycologia, 793-825.
Fromtling, R. A., & Bulmer, G. S. (1978). In vitro effect of aqueous extract of garlic (Allium sativum) on the growth and viability of Cryptococcus neoformans. Mycologia, 397-405.
Dankert, J., Tromp, T. F., De Vries, H., & Klasen, H. J. (1979). Antimicrobial activity of crude juices of Allium ascalonicum, Allium cepa and Allium sativum. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie, 245(1-2), 229-239.
Kamanna, V. S., & Chandrasekhara, N. (1982). Effect of garlic (Allium sativum Linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol.Lipids, 17(7), 483-488.
Adetumbi MA,Lau BH (1983). Allium sativum (garlic)–a natural antibiotic. Med Hypotheses; 12(3):227-37.
Lau, B. H., Adetumbi, M. A., & Sanchez, A. (1983). Allium sativum (garlic) and atherosclerosis: a review. Nutrition research, 3(1), 119-128.
Qureshi, A. A., Abuirmeileh, N., Din, Z. Z., Elson, C. E., & Burger, W. C. (1983). Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic. Lipids,18(5), 343-348.
Delaha, E. C., & Garagusi, V. F. (1985). Inhibition of mycobacteria by garlic extract (Allium sativum). Antimicrobial agents and chemotherapy, 27(4), 485-486.
Adetumbi, M., Javor, G. T., & Lau, B. H. (1986). Allium sativum (garlic) inhibits lipid synthesis by Candida albicans. Antimicrobial agents and chemotherapy, 30(3), 499-501.
Ernst, E. (1986). Cardiovascular effects of garlic (Allium sativum): a review. Pharmatherapeutica, 5(2), 83-89.
Mohammad, S. F., & Woodward, S. C. (1986). Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (garlic).Thrombosis research, 44(6), 793-806.
Kendler, B. S. (1987). Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Preventive medicine, 16(5), 670-685.
Wargovich, M. J. (1987). Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethyihydrazine-induced colon cancer. Carcinogenesis, 8(3), 487-489.
Ghannoum, M. A. (1988). Studies on the anticandidal mode of action of Allium sativum (garlic). Journal of general microbiology, 134(11), 2917-2924.
Wargovich, M. J., Woods, C., Eng, V. W., Stephens, L. C., & Gray, K. (1988). Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide.Cancer Research, 48(23), 6872-6875.
You, W. C., Blot, W. J., Chang, Y. S., Ershow, A., Yang, Z. T., An, Q., … & Wang, T. G. (1989). Allium vegetables and reduced risk of stomach cancer. Journal of the National Cancer Institute, 81(2), 162-164.
Lau, B. H., Tadi, P. P., & Tosk, J. M. (1990). Allium sativum (garlic) and cancer prevention. Nutrition research, 10(8), 937-948.
Singh, U. P., Pandey, V. N., Wagner, K. G., & Singh, K. P. (1990). Antifungal activity of ajoene, a constituent of garlic (Allium sativum).Canadian journal of botany, 68(6), 1354-1356.
Brady, J. F., Ishizaki, H., Fukuto, J. M., Lin, M. C., Fadel, A., Gapac, J. M., & Yang, C. S. (1991). Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chemical research in toxicology,4(6), 642-647.
Hughes, B. G., & Lawson, L. D. (1991). Antimicrobial effects of Allium sativum L.(garlic), Allium ampeloprasum L.(elephant garlic), and Allium cepa L.(onion), garlic compounds and commercial garlic supplement products.Phytotherapy Research, 5(4), 154-158.
Kumar, R. O., Banerji, A., Kurup, C. R., & Ramasarma, T. (1991). The nature of inhibition of 3-hydroxy-3-methylglutaryl CoA reductase by garlic-derived diallyl disulfide.Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology, 1078(2), 219-225.
Lata, S., Saxena, K. K., Bhasin, V., Saxena, R. S., Kumar, A., & Srivastava, V. K. (1991). Beneficial effects of Allium sativum, Allium cepa and Commiphora mukul on experimental hyperlipidemia and atherosclerosis–a comparative evaluation. Journal of postgraduate medicine, 37(3), 132.
Block, E. (1992). The organosulfur chemistry of the genus Allium–implications for the organic chemistry of sulfur.Angewandte Chemie International Edition in English, 31(9), 1135-1178.
Dwivedi, C., Rohlfs, S., Jarvis, D., & Engineer, F. N. (1992). Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide.Pharmaceutical research, 9(12), 1668-1670.
Egen-Schwind, C., Eckard, R., & Kemper, F. H. (1992). Metabolism of garlic constituents in the isolated perfused rat liver.Planta medica, 58(04), 301-305.
Sendl, A., Schliack, M., Löser, R., Stanislaus, F., & Wagner, H. (1992). Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic. Atherosclerosis, 94(1), 79-85.
Sendl, A., Elbl, G., Steinke, B., Redl, K., Breu, W., & Wagner, H. (1992). Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta medica, 58(1), 1-7.
Gebhardt, R. (1993). Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes.Lipids, 28(7), 613-619.
Rees, L. P., Minney, S. F., Plummer, N. T., Slater, J. H., & Skyrme, D. A. (1993). A quantitative assessment of the antimicrobial activity of garlic (Allium sativum).World Journal of Microbiology and Biotechnology, 9(3), 303-307.
Gebhardt, R., Beck, H., & Wagner, K. G. (1994). Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism,1213(1), 57-62.
Yeh, Y. Y., & Yeh, S. M. (1994). Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis.Lipids, 29(3), 189-193.
Gebhardt, R. (1995). Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived organosulfur compounds.Phytomedicine, 2(1), 29-34.
Agarwal, K. C. (1996). Therapeutic actions of garlic constituents.Medicinal research reviews, 16(1), 111-124.
Augusti, K. T. (1996). Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian journal of experimental biology, 34(7), 634-640.
Bordia, A., Verma, S. K., & Srivastava, K. C. (1996). Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease. Prostaglandins, leukotrienes and essential fatty acids,55(3), 201-205.
Bordia, T., Mohammed, N., Thomson, M., & Ali, M. (1996). An evaluation of garlic and onion as antithrombotic agents.Prostaglandins, leukotrienes and essential fatty acids, 54(3), 183-186.
Gebhardt, R., & Beck, H. (1996). Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids,31(12), 1269-1276.
Hu, X., Benson, P. J., Srivastava, S. K., Mack, L. M., Xia, H., Gupta, V., … & Singh, S. V. (1996). GlutathioneS-Transferases of Female A/J Mouse Liver and Forestomach and Their Differential Induction by Anti-carcinogenic Organosulfides from Garlic. Archives of biochemistry and biophysics,336(2), 199-214.
Milner, J. A. (1996). Garlic: its anticarcinogenic and antiumorigenic properties. Nutrition reviews,54(11), S82.
Singh, S. V., Mohan, R. R., Agarwal, R., Benson, P. J., Hu, X., Rudy, M. A., … & Gupta, V. (1996). Novel Anti-Carcinogenic Activity of an Organosulfide from Garlic: Inhibition of H-RASOncogene Transformed Tumor Growthin Vivoby Diallyl Disulfide Is Associated with Inhibition of p21 H-ras Processing. Biochemical and biophysical research communications, 225(2), 660-665.
Steiner, M., Khan, A. H., Holbert, D., & Lin, R. I. (1996). A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids.The American journal of clinical nutrition,64(6), 866-870.
Sundaram, S. G., & Milner, J. A. (1996). Diallyl disulfide induces apoptosis of human colon tumor cells.Carcinogenesis, 17(4), 669-673.
Ahmed, R. S., & Sharma, S. B. (1997).Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc) in albino rats. Indian journal of experimental biology, 35(8), 841-843.
Ide, N., Nelson, A. B., & Lau, B. H. (1997). Aged garlic extract and its constituents inhibit Cu2+-induced oxidative modification of low density lipoprotein. Planta medica,63(03), 263-264.
Yeh, Y. Y., Lin, R. I., Yeh, S. M., & Evans, S. (1997). Garlic reduces plasma cholesterol in hypercholesterolemic men maintaining habitual diets. InFood Factors for Cancer Prevention (pp. 226-230). Springer Japan.
Abrams, G. A., & Fallon, M. B. (1998). Treatment of hepatopulmonary syndrome with Allium sativum L.(garlic): a pilot trial. Journal of clinical gastroenterology, 27(3), 232-235.
Bordia A. (1998). [Garlic and coronary heart disease. Results of a 3-year treatment with garlic extract on the reinfarction and mortality rate]. Deutsche Apotheker Zeitung ;129(28 suppl 15):16-17.
Dirsch, V. M., Gerbes, A. L., & Vollmar, A. M. (1998). Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor κB. Molecular pharmacology,53(3), 402-407.
McCrindle BW, Helden E, Conner WT. Alternative medicine — a randomized double blind placebo-controlled clinical trial of garlic in hypercholesterolemic children [white diamond suit] 661. Pediatric Res 1998;43(4 suppl 2):115.
Sparnins, V. L., Barany, G., & Wattenberg, L. W. (1988). Effects of organosulfur compounds from garlic and onions on benzo [a] pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis,9(1), 131-134.
Suetsuna, K. (1998). Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic). The Journal of Nutritional Biochemistry, 9(7), 415-419.
Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic.Microbes and infection, 1(2), 125-129.
Helen, A., Rajasree, C. R., Krishnakumar, K., Augusti, K. T., & Vijayammal, P. L. (1999). Antioxidant role of oils isolated from garlic (Allium sativum Linn) and onion (Allium cepa Linn) on nicotine-induced lipid peroxidation. Veterinary and human toxicology, 41(5), 316-319.
Koscielny, J., Klüßendorf, D., Latza, R., Schmitt, R., Radtke, H., Siegel, G., & Kiesewetter, H. (1999). The antiatherosclerotic effect of Allium sativum. Atherosclerosis, 144(1), 237-249.
Lea, M. A., Randolph, V. M., & Patel, M. (1999). Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. International journal of oncology, 15(2), 347-352.
Xu, S., & Cho, B. S. (1999). Allyl mercaptan, a major metabolite of garlic compounds, reduces cellular cholesterol synthesis and its secretion in Hep-G2 cells.The Journal of nutritional biochemistry, 10(11), 654-659.
Ahmed, N., Laverick, L., Sammons, J., Zhang, H., Maslin, D. J., & Hassan, H. T. (2000). Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells.Anticancer research, 21(5), 3519-3523.
Ali, M., Thomson, M., & Afzal, M. (2000). Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance.Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 62(2), 55-73.
Aouadi, R., Aouidet, A., Elkadhi, A., Rayana, M. C. B., Jaafoura, H., Tritar, B., & Nagati, K. (2000). Effect of fresh garlic (Allium sativum) on lipid metabolism in male rats.Nutrition research, 20(2), 273-280.
Avato, P., Tursi, F., Vitali, C., Miccolis, V., & Candido, V. (2000). Allylsulfide constituents of garlic volatile oil as antimicrobial agents. Phytomedicine,7(3), 239-243.
Cho, B. S., & Xu, S. (2000). Effects of allyl mercaptan and various allium-derived compounds on cholesterol synthesis and secretion in Hep-G2 cells. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology,126(2), 195-201.
Fleischauer, A. T., Poole, C., & Arab, L. (2000). Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers.The American journal of clinical nutrition, 72(4), 1047-1052.
Gómez, L. G., & Muniz, F. S. (2000). Revisión: Efectos cardiovasculares del ajo(Allium sativum). Archivos Latinoamericanos de Nutrición, 50(3).
Hirsch, K., Danilenko, M., Giat, J., Miron, T., Rabinkov, A., Wilchek, M., … & Sharoni, Y. (2000). Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation.Nutrition and cancer, 38(2), 245-254.
Hong, Y. S., Ham, Y. A., Choi, J. H., & Kim, J. (2000). Effects of allyl sulfur compounds and garlic extract on the expressions of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines. Experimental and Molecular Medicine, 32(3), 127-134.
Knowles, L. M., & Milner, J. A. (2000). Diallyl disulfide inhibits p34cdc2 kinase activity through changes in complex formation and phosphorylation.Carcinogenesis,21(6), 1129-1134.
Lamm, D. L., & Riggs, D. R. (2000). The potential application of Allium sativum (garlic) for the treatment of bladder cancer.Urologic Clinics of North America,27(1), 157-162.
Liu, L., & Yeh, Y. Y. (2000). Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic.Lipids, 35(2), 197-203.
Stevinson, C., Pittler, M. H., & Ernst, E. (2000). Garlic for treating hypercholesterolemia: a meta-analysis of randomized clinical trials.Annals of internal medicine, 133(6), 420-429.
Ackermann RT, Mulrow CD, Ramirez G, et al. (2001). Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med ; 161(6):813-824.
Borek, C. (2001). Antioxidant health effects of aged garlic extract. The Journal of nutrition, 131(3), 1010S-1015S.
Fleischauer AT, Arab L. (2001). Garlic and cancer: a critical review of the epidemiologic literature. J Nutr ;131(3s):1032S-1040S.
Gupta, N., & Porter, T. D. (2001). Garlic and garlic-derived compounds inhibit human squalene monooxygenase.The Journal of nutrition, 131(6), 1662-1667.
Harris, J. C., Cottrell, S., Plummer, S., & Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). Applied Microbiology and Biotechnology, 57(3), 282-286.
Iqbal, Z., Nadeem, Q. K., Khan, M. N., Akhtar, M. S., & Waraich, F. N. (2001). In vitro anthelmintic activity of Allium sativum, Zingiber officinale, Curcurbita mexicana and Ficus religiosa.Int J Agri Biol, 3(4), 454-457.
Josling P. (2001). Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther ;18(4):189-193.
Knowles, L. M., & Milner, J. A. (2001). Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. The Journal of nutrition,131(3), 1061S-1066S.
Lamm, D. L., & Riggs, D. R. (2001). Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies. The Journal of nutrition,131(3), 1067S-1070S.
McNulty, C. A., Wilson, M. P., Havinga, W., Johnston, B., O’Gara, E. A., & Maslin, D. J. (2001). A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.Helicobacter, 6(3), 249-253.
Milner, J. A. (2001). Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. InNutrition and Cancer Prevention (pp. 69-81). Springer US.
Milner, J. A. (2001). A historical perspective on garlic and cancer.The Journal of nutrition, 131(3), 1027S-1031S.
Nakagawa, H., Tsuta, K., Kiuchi, K., Senzaki, H., Tanaka, K., Hioki, K., & Tsubura, A. (2001). Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis, 22(6), 891-897.
Rahman, K. (2001). Historical perspective on garlic and cardiovascular disease.The journal of nutrition, 131(3), 977S-979S.
Rivlin, R. S. (2001). Historical perspective on the use of garlic.The Journal of nutrition, 131 (3), 951S-954S.
Siegel G. (2001). Long-term effect of garlic in preventing arteriosclerosis – results of two controlled clinical trials. Eur Phytojournal ;Symposium posters(1):1.
Wu, C. C., Sheen, L. Y., Chen, H. W., Tsai, S. J., & Lii, C. K. (2001). Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. Food and Chemical toxicology,39(6), 563-569.
Yang, C. S., Chhabra, S. K., Hong, J. Y., & Smith, T. J. (2001). Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. The Journal of nutrition, 131(3), 1041S-1045S.
Andrianova IV, Fomchenkov IV, Orekhov AN. (2002). [Hypertensive effect of long-acting garlic tablets allicor (a double-blind placebo-controlled trial)]. Ter Arkh; 74(3):76-78.
Bose, C., Guo, J., Zimniak, L., Srivastava, S. K., Singh, S. P., Zimniak, P., & Singh, S. V. (2002). Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic. Carcinogenesis,23(10), 1661-1665.
Germain, E., Auger, J., Ginies, C., Siess, M. H., & Teyssier, C. (2002). In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites. Xenobiotica,32(12), 1127-1138.
Hodge, G., Hodge, S., & Han, P. (2002). Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry, 48(4), 209-215.
Hsing, A. W., Chokkalingam, A. P., Gao, Y. T., Madigan, M. P., Deng, J., Gridley, G., & Fraumeni, J. F. (2002). Allium vegetables and risk of prostate cancer: a population-based study. Journal of the National Cancer Institute,94(21), 1648-1651.
Ku, D. D., Abdel‐Razek, T. T., Dai, J., Kim‐Park, S., Fallon, M. B., & Abrams, G. A. (2002). Garlic And Its Active Metabolite Allicin Produce Endothelium‐And Nitric Oxide‐Dependent Relaxation In Rat Pulmonary Arteries. Clinical and Experimental Pharmacology and Physiology, 29(1‐2), 84-91.
Kwon, K. B., Yoo, S. J., Ryu, D. G., Yang, J. Y., Rho, H. W., Kim, J. S., … & Park, B. H. (2002). Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochemical pharmacology,63(1), 41-47.
Lea, M. A., Rasheed, M., Randolph, V. M., Khan, F., Shareef, A., & DesBordes, C. (2002). Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine. Nutrition and cancer,43(1), 90-102.
Lemar, K. M., Turner, M. P., & Lloyd, D. (2002). Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts. Journal of Applied Microbiology, 93(3), 398-405.
Li, M., Ciu, J. R., Ye, Y., Min, J. M., Zhang, L. H., Wang, K., … & Leung-Tack, J. (2002). Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.Carcinogenesis, 23(4), 573-579.
Li, M., Min, J. M., Cui, J. R., Zhang, L. H., Wang, K., Valette, A., … & Leung-Tack, J. (2002). Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage. Nutrition and cancer, 42(2), 241-247.
Limuro, M., Shibata, H., Kawamori, T., Matsumoto, T., Arakawa, T., Sugimura, T., & Wakabayashi, K. (2002). Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils. Cancer letters,187(1), 61-68.
Liu, L., & Yeh, Y. Y. (2002). S-alk (en) yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes.The Journal of nutrition, 132(6), 1129-1134.
Nishikawa, T., Yamada, N., Hattori, A., Fukuda, H., & Fujino, T. (2002). Inhibition by ajoene of skin-tumor promotion in mice.Bioscience, biotechnology, and biochemistry, 66(10), 2221-2223.
Balasenthil, S., Rao, K. S., & Nagini, S. (2003). Retinoic acid receptor-beta mRNA expression during chemoprevention of hamster cheek pouch carcinogenesis by garlic. Asia Pacific journal of clinical nutrition,12(2), 215-218.
Filomeni, G., Aquilano, K., Rotilio, G., & Ciriolo, M. R. (2003). Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide.Cancer research, 63(18), 5940-5949.
Higuchi, O., Tateshita, K., & Nishimura, H. (2003). Antioxidative activity of sulfur-containing compounds in Allium species for human low-density lipoprotein (LDL) oxidation in vitro.Journal of agricultural and food chemistry, 51(24), 7208-7214.
Keiss, H. P., Dirsch, V. M., Hartung, T., Haffner, T., Trueman, L., Auger, J., … & Vollmar, A. M. (2003). Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-κB Activity.The Journal of nutrition, 133(7), 2171-2175.
Markowitz, J. S., DeVane, C. L., Chavin, K. D., Taylor, R. M., Ruan, Y., & Donovan, J. L. (2003). Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clinical Pharmacology & Therapeutics, 74(2), 170-177.
Thomson, M., & Ali, M. (2003). Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent.Current cancer drug targets, 3(1), 67-81.
Tilli, C. M. L. J., Stavast-Kooy, A. J. W., Vuerstaek, J. D. D., Thissen, M. R. T. M., Krekels, G. A. M., Ramaekers, F. C. S., & Neumann, H. A. M. (2003). The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis.Archives of dermatological research, 295(3), 117-123.
Benkeblia, N. (2004). Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum). LWT-Food Science and Technology, 37(2), 263-268.
Chen, C., Pung, D., Leong, V., Hebbar, V., Shen, G., Nair, S., … & Kong, A. N. T. (2004). Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.Free Radical Biology and Medicine, 37(10), 1578-1590.
Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duée, P. H., & Chaumontet, C. (2004). Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines.Carcinogenesis, 25(7), 1227-1236.
Druesne N, Pagniez A, Mayeur C, Thomas M, Cherbuy C, Duee PH, Martel P, Chaumontet C. Repetitive treatments of colon HT-29 cells with diallyl disulfide induce a prolonged hyperacetylation of histone H3 K14.Ann N Y Acad Sci. 2004;1030:612–21.
Hassan HT. (2004). Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leuk Res 2004;28(7):667-671.
Meyer, K., Ueberham, E., & Gebhardt, R. (2004). Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their inhibitor TIMP-1 by cultured HUVEC cells. Cell biology and toxicology,20(4), 253-260.
Saravanan, G., & Prakash, J. (2004). Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats. Journal of ethnopharmacology, 94(1), 155-158.
Turner, B., Molgaard, C., & Marckmann, P. (2004). Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. British journal of nutrition,92(4), 701-706.
Xiao, D., Choi, S., Johnson, D. E., Vogel, V. G., Johnson, C. S., Trump, D. L., … & Singh, S. V. (2004). Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene,23(33), 5594-5606.
Yuan, J. P., Wang, G. H., Ling, H., Su, Q., Yang, Y. H., Song, Y., … & Huang, C. (2004). Diallyl disulfide-induced G2/M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways.World journal of gastroenterology, 10(18), 2731-2734.
Ashraf R, Aamir K, Shaikh AR, et al. (2005). Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad. 17(3):60-4.
Bakri, I. M., & Douglas, C. W. I. (2005). Inhibitory effect of garlic extract on oral bacteria. Archives of Oral Biology, 50(7), 645-651.
Davenport, D. M., & Wargovich, M. J. (2005). Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. Food and chemical toxicology,43(12), 1753-1762.
Gedik, N., Kabasakal, L., Şehirli, Ö., Ercan, F., Sirvancı, S., Keyer-Uysal, M., & Şener, G. (2005). Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats.Life sciences,76(22), 2593-2606.
Herman-Antosiewicz, A., & Singh, S. V. (2005). Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells. Journal of Biological Chemistry,280(31), 28519-28528.
Hosono, T., Fukao, T., Ogihara, J., Ito, Y., Shiba, H., Seki, T., & Ariga, T. (2005). Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of β-tubulin.Journal of Biological Chemistry, 280(50), 41487-41493.
Kwon, S. K., & Moon, A. (2005). Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activity.Archives of pharmacal research, 28(4), 391-394.
Lawson, L. D., & Gardner, C. D. (2005). Composition, stability, and bioavailability of garlic products used in a clinical trial.Journal of agricultural and food chemistry, 53(16), 6254-6261.
Mousa, A. S., & Mousa, S. A. (2005). Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutrition and cancer,53(1), 104-110.
Onyeagba, R. A., Ugbogu, O. C., Okeke, C. U., & Iroakasi, O. (2005). Studies on the antimicrobial effects of garlic (Allium sativum Linn), ginger (Zingiber officinale Roscoe) and lime (Citrus aurantifolia Linn). African Journal of Biotechnology, 3(10), 552-554.
Sabitha, P., Adhikari, P. M., Shenoy, S. M., Kamath, A., John, R., Prabhu, M. V., & Padmaja, U. (2005). Efficacy of garlic paste in oral candidiasis. Tropical doctor,35(2), 99-99.
Şener, G., Ipçi, Y., Ercan, F., Gedik, N., & Yeĝen, B. Ç. (2005). Aqueous garlic extract alleviates ischaemia‐reperfusion‐induced oxidative hepatic injury in rats. Journal of Pharmacy and Pharmacology,57(1), 145-150.
Tsai, C. W., Yang, J. J., Chen, H. W., Sheen, L. Y., & Lii, C. K. (2005). Garlic organosulfur compounds upregulate the expression of the π class of glutathione S-transferase in rat primary hepatocytes.The Journal of nutrition,135(11), 2560-2565.
Wu, X. J., Kassie, F., & Mersch-Sundermann, V. (2005). The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 579(1), 115-124.
Xiao, D., Herman-Antosiewicz, A., Antosiewicz, J., Xiao, H., Brisson, M., Lazo, J. S., & Singh, S. V. (2005). Diallyl trisulfide-induced G2–M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C. Oncogene,24(41), 6256-6268.
Amagase, H. (2006). Clarifying the real bioactive constituents of garlic.The Journal of nutrition, 136(3), 716S-725S.
Arunkumar, A., Vijayababu, M. R., Srinivasan, N., Aruldhas, M. M., & Arunakaran, J. (2006). Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3. Molecular and cellular biochemistry,288(1-2), 107-113.
Chu, Q., Ling, M. T., Feng, H., Cheung, H. W., Tsao, S. W., Wang, X., & Wong, Y. C. (2006). A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression.Carcinogenesis, 27(11), 2180-2189.
Chung, L. Y. (2006). The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide.Journal of medicinal food, 9(2), 205-213.
Eidi, A., Eidi, M., & Esmaeili, E. (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine,13(9), 624-629.
Gail, M. H., & You, W. C. (2006). A factorial trial including garlic supplements assesses effect in reducing precancerous gastric lesions.The Journal of nutrition, 136(3), 813S-815S.
Galeone, C., Pelucchi, C., Levi, F., Negri, E., Franceschi, S., Talamini, R., … & La Vecchia, C. (2006). Onion and garlic use and human cancer. The American journal of clinical nutrition,84(5), 1027-1032.
Ishikawa, H., Saeki, T., Otani, T., Suzuki, T., Shimozuma, K., Nishino, H., … & Morimoto, K. (2006). Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer.The Journal of nutrition, 136(3), 816S-820S.
Lau, B. H. (2006). Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. The Journal of nutrition,136(3), 765S-768S.
Leelarungrayub, N., Rattanapanone, V., Chanarat, N., & Gebicki, J. M. (2006). Quantitative evaluation of the antioxidant properties of garlic and shallot preparations. Nutrition,22(3), 266-274.
Li, N., Guo, R., Li, W., Shao, J., Li, S., Zhao, K., … & Lu, Y. (2006). A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide.Carcinogenesis, 27(6), 1222-1231.
Liu, C. T., Wong, P. L., Lii, C. K., Hse, H., & Sheen, L. Y. (2006). Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes.Food and chemical toxicology, 44(8), 1377-1384.
Matsuura, N., Miyamae, Y., Yamane, K., Nagao, Y., Hamada, Y., Kawaguchi, N., & Ishikawa, H. (2006). Aged garlic extract inhibits angiogenesis and proliferation of colorectal carcinoma cells. The Journal of nutrition,136(3), 842S-846S.
Pinto, J. T., Krasnikov, B. F., & Cooper, A. J. (2006). Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives.The Journal of nutrition, 136(3), 835S-841S.
Rahman, K., & Lowe, G. M. (2006). Garlic and cardiovascular disease: a critical review.The Journal of nutrition, 136(3), 736S-740S.
Singh, D. K., & Porter, T. D. (2006). Inhibition of sterol 4α-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. The Journal of nutrition,136(3), 759S-764S.
Singh, V., Belloir, C., Siess, M. H., & Le Bon, A. M. (2006). Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content. Nutrition and cancer,55(2), 178-184.
Tanaka, S., Haruma, K., Yoshihara, M., Kajiyama, G., Kira, K., Amagase, H., & Chayama, K. (2006). Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. The Journal of nutrition,136(3), 821S-826S.
Taubert, D., Glöckner, R., Müller, D., & Schömig, E. (2006). The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide.Toxicology letters, 164(1), 1-5.
Taylor, P., Noriega, R., Farah, C., Abad, M. J., Arsenak, M., & Apitz, R. (2006). Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice.Cancer letters, 239(2), 298-304.
Uda, N., Kashimoto, N., Sumioka, I., Kyo, E., Sumi, S. I., & Fukushima, S. (2006). Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. The Journal of nutrition,136(3), 855S-860S.
Xiao, D., Lew, K. L., Kim, Y. A., Zeng, Y., Hahm, E. R., Dhir, R., & Singh, S. V. (2006). Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.Clinical Cancer Research, 12(22), 6836-6843.
Xiao, D., Li, M., Herman-Antosiewicz, A., Antosiewicz, J., Xiao, H., Lew, K. L., … & Singh, S. V. (2006). Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2.Nutrition and cancer, 55(1), 94-107.
Xiao, D., & Singh, S. V. (2006). Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells.Carcinogenesis, 27(3), 533-540.
Ban, J. O., Yuk, D. Y., Woo, K. S., Kim, T. M., Lee, U. S., Jeong, H. S., … & Hong, J. T. (2007). Inhibition of Cell Growth and Induction of Apoptosis via Inactivation of NF-. KAPPA. B by a Sulfurcompound Isolated From Garlic in Human Colon Cancer Cells. Journal of pharmacological sciences,104(4), 374-383.
Borrelli, F., Capasso, R., & Izzo, A. A. (2007). Garlic (Allium sativum L.): adverse effects and drug interactions in humans.Molecular nutrition & food research, 51(11), 1386-1397.
Chan, K. C., Yin, M. C., & Chao, W. J. (2007). Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Food and chemical toxicology, 45(3), 502-507.
Chu, Q., Lee, D. T., Tsao, S. W., Wang, X., & Wong, Y. C. (2007). S‐allylcysteine, a water‐soluble garlic derivative, suppresses the growth of a human androgen‐independent prostate cancer xenograft, CWR22R, under in vivo conditions.BJU international,99(4), 925-932.
Das, A., Banik, N. L., & Ray, S. K. (2007). Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells.Cancer, 110(5), 1083-1095.
Fani, M. M., Kohanteb, J., & Dayaghi, M. (2007). Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans.Journal of Indian Society of Pedodontics and Preventive Dentistry, 25(4), 164.
Gardner, C. D., Lawson, L. D., Block, E., Chatterjee, L. M., Kiazand, A., Balise, R. R., & Kraemer, H. C. (2007). Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial.Archives of internal medicine, 167(4), 346-353.
Herman-Antosiewicz, A., Stan, S. D., Hahm, E. R., Xiao, D., & Singh, S. V. (2007). Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1–dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic.Molecular cancer therapeutics, 6(4), 1249-1261.
Herman-Antosiewicz, A., Powolny, A. A., & Singh, S. V. (2007). Molecular targets of cancer chemoprevention by garlic‐derived organosulfides. Acta pharmacologica Sinica,28(9), 1355-1364.
Karmakar, S., Banik, N. L., Patel, S. J., & Ray, S. K. (2007). Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis,12(4), 671-684.
Kim, Y. A., Xiao, D., Xiao, H., Powolny, A. A., Lew, K. L., Reilly, M. L., … & Singh, S. V. (2007). Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.Molecular cancer therapeutics, 6(5), 1599-1609.
Shukla, Y., & Kalra, N. (2007). Cancer chemoprevention with garlic and its constituents. Cancer letters,247(2), 167-181.
Bozin, B., Mimica-Dukic, N., Samojlik, I., Goran, A., & Igic, R. (2008). Phenolics as antioxidants in garlic (Allium sativum L., Alliaceae). Food chemistry, 111(4), 925-929.
Fujisawa, H., Suma, K., Origuchi, K., Kumagai, H., Seki, T., & Ariga, T. (2008). Biological and chemical stability of garlic-derived allicin. Journal of agricultural and food chemistry,56(11), 4229-4235.
O’Donnell, G., Poeschl, R., Zimhony, O., Gunaratnam, M., Moreira, J. B., Neidle, S., & Lenaerts, A. (2008). Bioactive Pyridine-N-oxide Disulfides from Allium stipitatum.Journal of natural products, 72(3), 360-365.
Powolny, A. A., & Singh, S. V. (2008). Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.Cancer letters, 269(2), 305-314.
Singh, S. V., Powolny, A. A., Stan, S. D., Xiao, D., Arlotti, J. A., Warin, R., … & Dhir, R. (2008). Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice.Cancer research, 68(22), 9503-9511.
Azamthulla, M., Asad, M., & Prasad, V. S. (2009). Antiulcer activity of Allium sativum bulb juice in rats. Saudi Pharm J,17(1), 70-7.
Kim, J. Y., & Kwon, O. (2009). Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims.The American journal of clinical nutrition, 89(1), 257-264.
Stan, S. D., & Singh, S. V. (2009). Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells. Clinical Cancer Research,15(15), 4895-4903.
Xiao, D., Zeng, Y., & Singh, S. V. (2009). Diallyl trisulfide‐induced apoptosis in human cancer cells is linked to checkpoint kinase 1‐mediated mitotic arrest. Molecular carcinogenesis,48(11), 1018-1029.
Chandra-Kuntal, K., & Singh, S. V. (2010). Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo.Cancer Prevention Research,3(11), 1473-1483.
Liu, S., Sun, Y., Li, W., Yu, H., Li, X., Liu, Z., … & Jia, J. (2010). The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection.FEMS microbiology letters, 303(2), 183-189.
Heidarian, E., Jafari-Dehkordi, E., & Seidkhani-Nahal, A. (2011). Effect of garlic on liver phosphatidate phosphohydrolase and plasma lipid levels in hyperlipidemic rats.Food and Chemical Toxicology,49(5), 1110-1114.
Lee, Y., Kim, H., Lee, J., & Kim, K. (2011). Anticancer activity of S-allylmercapto-L-cysteine on implanted tumor of human gastric cancer cell. Biological and Pharmaceutical Bulletin,34(5), 677-681.
Shirzad, H., Taji, F., & Rafieian-Kopaei, M. (2011). Correlation between antioxidant activity of garlic extracts and WEHI-164 fibrosarcoma tumor growth in BALB/c mice.Journal of medicinal food, 14(9), 969-974.
Ashraf, R., Khan, R. A., Ashraf, I., & Qureshi, A. A. (2013). Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci, 26(5), 859-63.
Capasso, A. (2013). Antioxidant action and therapeutic efficacy of Allium sativum L.Molecules, 18(1), 690-700.
Chu, Y. L., Ho, C. T., Chung, J. G., Raghu, R., Lo, Y. C., & Sheen, L. Y. (2013). Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy.Journal of agricultural and food chemistry, 61(41), 9839-9848.
Elkayam, A., Peleg, E., Grossman, E., Shabtay, Z., & Sharabi, Y. (2013). Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats.Isr Med Assoc J, 15(3), 170-3.
Kim, Y. S., Jung, D. H., Lee, I. S., Choi, S. J., Yu, S. Y., Ku, S. K., … & Kim, J. S. (2013). Effects of Allium victorialis leaf extracts and its single compounds on aldose reductase, advanced glycation end products and TGF-β1 expression in mesangial cells.BMC complementary and alternative medicine,13(1), 1.
Ried, K., Toben, C., & Fakler, P. (2013). Effect of garlic on serum lipids: an updated meta-analysis. Nutrition reviews,71(5), 282-299.
Charron, C. S., Dawson, H. D., Albaugh, G. P., Solverson, P. M., Vinyard, B. T., Solano-Aguilar, G. I.,… & Novotny, J. A. (2015). A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity-and Cancer-Related Genes in Whole Blood of Humans. The Journal of nutrition,145(11), 2448-2455.
Bradley, J. M., Organ, C. L., & Lefer, D. J. (2016). Garlic-derived organic polysulfides and myocardial protection.The Journal of nutrition, 146(2), 403S-409S.
Charron, C. S., Dawson, H. D., & Novotny, J. A. (2016). Garlic Influences Gene Expression In Vivo and In Vitro.The Journal of nutrition, 146(2), 444S-449S.
Shafiekhani, M., Faridi, P., Kojuri, J., & Namazi, S. (2016). Comparison of antiplatelet activity of garlic tablets with cardio-protective dose of aspirin in healthy volunteers: a randomized clinical trial. Avicenna Journal of Phytomedicine,6(5), 550-557.
Sobenin, I. A., Andrianova, I. V., Lakunin, K. Y., Karagodin, V. P., Bobryshev, Y. V., & Orekhov, A. N. (2016). Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits.Phytomedicine, 23(11), 1235-1239.
Suangtamai, T., & Tanyong, D. I. (2016). Diallyl disulfide induces apoptosis and autophagy via mTOR pathway in myeloid leukemic cell line. Tumor Biology, 1-7.
Zhuang, J., Li, Y., & Chi, Y. (2016). Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells. Anti-cancer drugs,27(4), 312-317.
Zaidi, S. K., Ansari, S. A., Tabrez, S., Hoda, M. N., Ashraf, G. M., Khan, M. S.,… & Al-Qahtani, M. H. (2017). Garlic extract attenuates immobilization stress-induced alterations in plasma antioxidant/oxidant parameters and hepatic function in rats. Chinese journal of integrative medicine.
1. Ahmadi, A., & Shadboorestan, A. (2015). Oxidative Stress and Cancer; The Role of Hesperidin, a Citrus Natural Bioflavonoid, as a Cancer Chemoprotective Agent. Nutrition and cancer, 1-12.
2. Alam, M. A., Subhan, N., Rahman, M. M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014). Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition: An International Review Journal, 5(4), 404-417.
3. Ameer, B., Weintraub, R. A., Johnson, J. V., Yost, R. A., & Rouseff, R. L. (1996). Flavanone absorption after naringin, hesperidin, and citrus administration. Clinical Pharmacology &Therapeutics, 60(1), 34-40.
4. Aptekmann, N. P., & Cesar, T. B. (2010). Orange juice improved lipid profile and blood lactateof overweight middle-aged women subjected to aerobic training. Maturitas, 67(4), 343-347.
(Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. Foodand chemical toxicology, 46(8), 2770-2775.
6. Arbo, M. D., Schmitt, G. C., Limberger, M. F., Charão, M. F., Moro, Â. M., Ribeiro, G. L., …& Limberger, R. P. (2009). Subchronic toxicity of Citrus aurantium L.(Rutaceae) extract and psynephrine in mice. Regulatory Toxicology and Pharmacology,54(2), 114-117.
7. Arias, B. A., & Ramón-Laca, L. (2005). Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean region. Journal of Ethnopharmacology, 97(1), 89-95.
8. Asgary, S., & Keshvari, M. (2013). Effects of citrus sinensis juice on blood pressure. ARYAatherosclerosis, 9(1), 98.
9. Avula, B., Upparapalli, S. K., Navarrete, A., & Khan, I. A. (2005). Simultaneous quantificationof adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietarysupplements by liquid chromatography. Journal of AOAC International,88(6), 1593-1606.
10. Bae, J. M., Lee, E. J., & Guyatt, G. (2008). Citrus fruit intake and stomach cancer risk: aquantitative systematic review. Gastric Cancer, 11(1), 23-32.
11. Bae, J. M., Lee, E. J., & Guyatt, G. (2008). Citrus fruits intake and prostate cancer risk: aquantitative systematic review. J Prev Med Public Health, 41(3), 159-164.
12. Bailey, D. G., Spence, J. D., Munoz, C., & Arnold, J. M. O. (1991). Interaction of citrus juiceswith felodipine and nifedipine. The Lancet, 337(8736), 268-269.
13. Baldwin, E. A., Nisperos-Carriedo, M., Shaw, P. E., & Burns, J. K. (1995). Effect of coatingand prolonged storage conditions on fresh orange flavor volatiles, degrees Brix, and ascorbicacid levels. Journal of Agricultural and food chemistry, 43(5), 1321-1331.
14. Barreca, D., Bellocco, E., Caristi, C., Leuzzi, U., & Gattuso, G. (2011). Distribution of C-andO-glycosyl flavonoids,(3-hydroxy-3-methylglutaryl) glycosyl flavanones and furocoumarins inCitrus aurantium L. juice. Food Chemistry,124(2), 576-582.
15. Barreca, D., Gattuso, G., Laganà, G., Leuzzi, U., & Bellocco, E. (2016). C-and O-glycosylflavonoids in Sanguinello and Tarocco blood orange (Citrus sinensis (L.) Osbeck) juice:Identification and influence on antioxidant properties and acetylcholinesterase activity. Foodchemistry, 196, 619-627.
16. BasiLe, L. G., Lima, C. G., & Cesar, T. B. (2010). Daily intake of pasteurized orange juicedecreases serum cholesterol, fasting glucose and diastolic blood pressure in adults. In Proc.Florida State Hortic. Soc (Vol. 123, pp. 228-233).
17. Benavente-Garcia, O., & Castillo, J. (2008). Update on uses and properties of citrus flavonoids:new findings in anticancer, cardiovascular, and anti-inflammatory activity. Journal ofagricultural and food chemistry, 56(15), 6185-6205.
18. Benavente-García, O., Castillo, J., Marin, F. R., Ortuño, A., & Del Río, J. A. (1997). Uses andproperties of citrus flavonoids. Journal of Agricultural and Food Chemistry, 45(12), 4505-4515.
19. Bent, S., Padula, A., & Neuhaus, J. (2004). Safety and efficacy of citrus aurantium for weightloss. The American journal of cardiology, 94(10), 1359-1361.
20. Betoret, E., Betoret, N., Carbonell, J. V., & Fito, P. (2009). Effects of pressure homogenizationon particle size and the functional properties of citrus juices. Journal of foodengineering, 92(1), 18-23.
21. Bodet, C., La, V. D., Epifano, F., & Grenier, D. (2008). Naringenin has anti ‐inflammatoryproperties in macrophage and ex vivo human whole ‐blood models. Journal of periodontalresearch, 43(4), 400-407.
22. Bok, S. H., Lee, S. H., Park, Y. B., Bae, K. H., Son, K. H., Jeong, T. S., & Choi, M. S. (1999).Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoAreductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or amixture of citrus bioflavonoids.The Journal of nutrition, 129(6), 1182-1185.
23. Bonamin, F., Moraes, T. M., dos Santos, R. C., Kushima, H., Faria, F. M., Silva, M. A., … & daRocha, L. R. (2014). The effect of a minor constituent of essential oil from Citrus aurantium:The role of β-myrcene in preventing peptic ulcer disease. Chemico-biological interactions, 212,11-19.
24. Bonifacio, N. P., & César, T. B. (2007). Influência da ingestão regular do suco de laranja naredução da pressão arterial. Nutr Pauta, 83, 37-40.
25. Borradaile, N. M., Carroll, K. K., & Kurowska, E. M. (1999). Regulation of HepG2 cellapolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin. Lipids, 34(6),591-598.
26. Bredsdorff, L., Nielsen, I. L. F., Rasmussen, S. E., Cornett, C., Barron, D., Bouisset, F., … &Williamson, G. (2010)Absorption, conjugation and excretion of the flavanones, naringeninand hesperetin from α-rhamnosidase-treated orange juice in human subjects. British journal ofnutrition, 103(11), 1602-1609.
27. Brett, G. M., Hollands, W., Needs, P. W., Teucher, B., R Dainty, J., Davis, B. D., … & Kroon, P.A. (2009). Absorptionmetabolism and excretion of flavanones from single portions of orangefruit and juice and effects oanthropometric variables and contraceptive pill use on flavanoneexcretion. British journal of nutrition, 101(05), 664-675.
28. Bronner, W. E., & Beecher, G. R. (1995). Extraction and measurement of prominent flavonoidsin orange and grapefruit juice concentrates. Journal of Chromatography A, 705(2), 247-256.
29. Bruemmer, J. H., Roe, B., & Bowen R. (1976). Peroxidase reactions and orange juice quality.Journal of Food Science, 41(1), 186-189.
30. Bub, A., Watzl, B., Blockhaus, M., Briviba, K., Liegibel, U., Müller, H., … & Rechkemmer, G.(2003). Fruit juice consumption modulates antioxidative status, immune status and DNAdamage. The Journal of nutritional biochemistry, 14(2), 90-98.
31. Burgess, J. R., & Andrade, J. E. (2006). Antioxidant effects of citrus flavonoid consumption.Potential Health Benefits of Citrus, 936, 161-174.
adult subjects with increased cardiovascular risk. The American journal of clinicalnutrition, 95(5), 1089-1095.
33. Calapai, G., Firenzuoli, F., Saitta, A., Squadrito, F., Arlotta, M. R., Costantino, G., & Inferrera,G. (1999). Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: apreliminary report. Fitoterapia, 70(6), 586-592.
34. Cao, S., Liu, L., Lu, Q., Xu, Y., Pan, S., & Wang, K. (2009). Integrated effects of ascorbic acid,flavonoids and sugars on thermal degradation of anthocyanins in blood orange juice. EuropeanFood Research and Technology, 228(6), 975-983.
35. Carvalho-Freitas, M. I. R., & Costa, M. (2002). Anxiolytic and sedative effects of extracts andessential oil from Citrus aurantium L. Biological and Pharmaceutical Bulletin, 25(12), 1629-1633.
36. Castillo, J., Benavente, O., & del Rio, J. A. (1993). Hesperetin 7-O-glucoside and prunin inCitrus species (Caurantium and C. paradisi). A study of their quantitative distribution inimmature fruits and as immediate precursors of neohesperidin and naringin in Citrusaurantium. Journal of Agricultural and Food Chemistry, 41(11), 1920-1924.
37. Celano, M., Maggisano, V., De Rose, R. F., Bulotta, S., Maiuolo, J., Navarra, M., & Russo, D.(2015). Flavonoid Fractioof Citrus Reticulata Juice Reduces Proliferation and Migration ofAnaplastic Thyroid Carcinoma Cells. Nutritionand Cancer, 67(7), 1183-1190.
38. Cerletti, C., Gianfagna, F., Tamburrelli, C., De Curtis, A., D’Imperio, M., Coletta, W., … &Rotilio, D. (2015). Orange juice intake during a fatty meal consumption reduces thepostprandial low-grade inflammatory response in healthy subjects.Thrombosis research,135(2), 255-259.
39. Cesar, T. B., Aptekmann, N. P., Araujo, M. P., Vinagre, C. C., & Maranhão, R. C. (2010).Orange juice decreases lodensity lipoprotein cholesterol in hypercholesterolemic subjectsand improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemicsubjects. Nutrition Research,30(10), 689-694.
40. César, T. B., Rodrigues, L. U., Araújo, M. S. P. D., & Aptekmann, N. P. (2010). Suco de laranjareduz o colesterol eindivíduos normolipidêmicos. Revista de Nutrição, 779-789.
41. Chau, C. F., & Huang, Y. L. (2003). Comparison of the chemical composition andphysicochemical properties of different fibers prepared from the peel of Citrus sinensis L. Cv.Liucheng. Journal of Agricultural and Food Chemistry, 51(9), 2615-2618.
42. Chiba, H., Uehara, M., Wu, J., Wang, X., Masuyama, R., Suzuki, K., … & Ishimi, Y. (2003).Hesperidin, a citrus flavonoidinhibits bone loss and decreases serum and hepatic lipids inovariectomized mice. The Journal of nutrition, 133(6), 1892-1897.
43. Cho, H. W., Jung, S. Y., Lee, G. H., Cho, J. H., & Choi, I. Y. (2015). Neuroprotective effect ofCitrus unshiu immaturpeel and nobiletin inhibiting hydrogen peroxide-induced oxidativestress in HT22 murine hippocampal neuronal cells. Pharmacognosy magazine, 11(Suppl 2),S284.
44. Choudhury, R., Chowrimootoo, G., Srai, K., Debnam, E., & Rice-Evans, C. A. (1999).Interactions of the flavonoinaringenin in the gastrointestinal tract and the influence ofglycosylation. Biochemical and biophysical research communications, 265(2), 410-415.
45. Coelho, R. C. L. A., Hermsdorff, H. H. M., & Bressan, J. (2013). Anti-inflammatory propertiesof orange juice: possible favorable molecular and metabolic effects. Plant foods for humannutrition, 68(1), 1-10.
46. Coleman, R. L., Lund, E. D., & Moshonas, M. G. (1969). Composition of orange essenceoil. Journal of Food Science, 34(6), 610-611.
47. Colker, C. M., Kaiman, D. S., Torina, G. C., Perlis, T., & Street, C. (1999). Effects of Citrusaurantium extract, caffeine, and St. John’s wort on body fat loss, lipid levels, and mood states inoverweight healthy adults. Current Therapeutic Research, 60(3), 145-153.
48. Da Silva, J. (2005). Influence of orange juice over the genotoxicity induced by alkylatingagents: an in vivo analysisMutagenesis, 20(4), 279-283.
49. Dallas, C., Gerbi, A., Tenca, G., Juchaux, F., & Bernard, F. X. (2008). Lipolytic effect of apolyphenolic citrus dry extracof red orange, grapefruit, orange (SINETROL) in human bodyfat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE).Phytomedicine,15(10), 783-792.
50. De Moraes Pultrini, A., Galindo, L. A., & Costa, M. (2006). Effects of the essential oil fromCitrus aurantium L. in experimental anxiety models in mice. Life Sciences, 78(15), 1720-1725.
51. Demonty, I., Lin, Y., Zebregs, Y. E., Vermeer, M. A., van der Knaap, H. C., Jäkel, M., &Trautwein, E. A. (2010). The citrus flavonoids hesperidin and naringin do not affect serumcholesterol in moderately hypercholesterolemic men and women. The Journal ofnutrition, 140(9), 1615-1620.
52. Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., … &Dandona, P. (2010). Differentia effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 an suppressor of cytokine signaling-3.Diabetes care, 33(5), 991-997.
53. Devaraj, S., Jialal, I., & Vega-López, S. (2004). Plant sterol-fortified orange juice effectivelylowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), e25-e28.
54. Devaraj, S., Jialal, I., Rockwood, J., & Zak, D. (2011). Effect of orange juice and beverage withphytosterols on cytokines and PAI-1 activity. Clinical Nutrition,30(5), 668-671.
55. Deyhim, F., Garica, K., Lopez, E., Gonzalez, J., Ino, S., Garcia, M., & Patil, B. S. (2006).Citrus juice modulates bone strength in male senescent rat model of osteoporosis.Nutrition, 22(5), 559-563.
56. Dhuique-Mayer, C., Caris-Veyrat, C., Ollitrault, P., Curk, F., & Amiot, M. J. (2005). Varietaland interspecific influence on micronutrient contents in citrus from the Mediterranean area.Journal of Agricultural and Food Chemistry, 53(6), 2140-2145.
57. Di Donna, L., De Luca, G., Mazzotti, F., Napoli, A., Salerno, R., Taverna, D., & Sindona, G.(2009). Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. Journal of natural products,72(7), 1352-1354.
58. Dugo, P., Lo Presti, M., Öhman, M., Fazio, A., Dugo, G., & Mondello, L. (2005).Determination of flavonoids in citrus juices by micro ‐ HPLC ‐ESI/MS.Journal of SeparationScience, 28(11), 1149-1156.
59. Erlund, I. (2004). Review of the flavonoids quercetin, hesperetin, and naringenin. Dietarysources, bioactivities, bioavailability, and epidemiology. Nutrition Research, 24(10), 851-874.
60. Erlund, I., Kosonen, T., Alfthan, G., Mäenpää, J., Perttunen, K., Kenraali, J., … & Aro, A.(2000). Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.European journal of clinical pharmacology, 56(8), 545-553.
61. Erlund, I., Meririnne, E., Alfthan, G., & Aro, A. (2001). Plasma kinetics and urinary excretionof the flavanones naringenin and hesperetin in humans after ingestion of orange juice andgrapefruit juice. The Journal of nutrition, 131(2), 235-241.
62. Erlund, I., Silaste, M. L., Alfthan, G., Rantala, M., Kesäniemi, Y. A., & Aro, A. (2002). Plasmaconcentrations of the flavonoids hesperetin, naringenin and quercetin in human subjectsfollowing their habitual diets, and diets high or low in fruit and vegetables. European journalof clinical nutrition, 56(9), 891-898.
63. Fan, K., Kurihara, N., Abe, S., Ho, C. T., Ghai, G., & Yang, K. (2007). ChemopreventiveEffects of Orange Peel Extract (OPE) I. OPE Inhibits Intestinal Tumor Growth in ApcMin/+Mice. Journal of medicinal food,10(1), 11-17.
like effect of sweet orange aroma in Wistar rats. Progress in Neuro-Psychopharmacology andBiological Psychiatry, 34(4), 605-609.
65. Ferlazzo, N., Cirmi, S., Russo, M., Trapasso, E., Ursino, M. R., Lombardo, G. E., … & Navarra,M. (2016). NF- κB mediates the antiproliferative and proapoptotic effects of bergamot juice inHepG2 cells. Life Sciences.
66. Firenzuoli, F., Gori, L., & Galapai, C. (2005). Adverse reaction to an adrenergic herbal extract(Citrus aurantium). Phytomedicine, 12(3), 247-248.
67. Fisher, K., & Phillips, C. A. (2006). The effect of lemon, orange and bergamot essential oilsand their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeriamonocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems.Journal of Applied Microbiology, 101(6), 1232-1240.
68. Fomani, M., Happi, E. N., Bisoue, A. N., Ndom, J. C., Waffo, A. F. K., Sewald, N., & Wansi, J.D. (2016). Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloidsfrom Citrus reticulate (Blanco). Bioorganic & medicinal chemistry letters, 26(2), 306-309.
69. Franke, A. A., Cooney, R. V., Custer, L. J., Mordan, L. J., & Tanaka, Y. (1998). Inhibition ofneoplastic transformation and bioavailability of dietary flavonoid agents. Flavonoids in theliving system, 237-48.
70. Franke, A. A., Cooney, R. V., Henning, S. M., & Custer, L. J. (2005). Bioavailability andantioxidant effects of orange juice components in humans. Journal of agricultural and foodchemistry, 53(13), 5170-5178.
71. Franke, S. I. R., Prá, D., Giulian, R., Dias, J. F., Yoneama, M. L., Da Silva, J., … & Henriques,J. A. P. (2006). Influence of orange juice in the levels and in the genotoxicity of iron andcopper. Food and Chemical Toxicology, 44(3), 425-435.
72. Frerot, E., & Decorzant, E. (2004). Quantification of total furocoumarins in citrus oils byHPLC coupled with UV, fluorescence, and mass detection. Journal of agricultural and foodchemistry, 52(23), 6879-6886.
73. Fugh-Berman, A., & Myers, A. (2004). Citrus aurantium, an ingredient of dietary supplementsmarketed for weight loss: current status of clinical and basic research. Experimental biologyand medicine, 229(8), 698-704.
74. Galati, E. M., Monforte, M. T., Kirjavainen, S., Forestieri, A. M., Trovato, A., & Tripodo, M.M. (1994). Biological effects of hesperidin, a citrus flavonoid.(Note I): antiinflammatory andanalgesic activity. Farmaco (Societa chimica italiana: 1989),40(11), 709-712.
75. Garau, M. C., Simal, S., Rossello, C., & Femenia, A. (2007). Effect of air-drying temperatureon physico-chemical properties of dietary fibre and antioxidant capacity of orange (Citrusaurantium v. Canoneta) by-products. Food chemistry, 104(3), 1014-1024.
76. Garcia, A. C., Bonifácio, N. P., Vendramine, R. C., & Cesar, T. B. (2008). Influência doconsumo de suco de laranja nos lípides sangüíneos e na composição corporal de homensnormais e com dislipidemia. Nutrire, 33(2), 1-11.
77. Gardana, C., Guarnieri, S., Riso, P., Simonetti, P., & Porrini, M. (2007). Flavanone plasmapharmacokinetics from blood orange juice in human subjects. British journal ofnutrition, 98(01), 165-172.
78. Gattuso, G., Barreca, D., Gargiulli, C., Leuzzi, U., & Caristi, C. (2007). Flavonoid compositionof citrus juices. Molecules, 12(8), 1641-1673.
79. Gattuso, G., Caristi, C., Gargiulli, C., Bellocco, E., Toscano, G., & Leuzzi, U. (2006).Flavonoid glycosides in bergamot juice (Citrus bergamia Risso). Journal of agricultural andfood chemistry, 54(11), 3929-3935.
81. Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., … &Dandona, P. (2010). Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. TheAmerican journal of clinical nutrition, 91(4), 940-949.
82. Ghasemi, K., Ghasemi, Y., & Ebrahimzadeh, M. A. (2009). Antioxidant activity, phenol andflavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci, 22(3), 277-281.
83. Gil-Izquierdo, A., Gil, M. I., & Ferreres, F. (2002). Effect of processing techniques at industrialscale on orange juice antioxidant and beneficial health compounds. Journal of Agricultural andFood Chemistry, 50(18), 5107-5114.
86. Giménez-Bastida, J. A., González-Sarrías, A., Vallejo, F., Espín, J. C., & Tomás-Barberán, F. A.(2016). Hesperetin anits sulfate and glucuronide metabolites inhibit TNF- α induced humanaortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1)levels. Food & function.
87. Goes, T. C., Antunes, F. D., Alves, P. B., & Teixeira-Silva, F. (2012). Effect of sweet orangearoma on experimental anxiety in humans. The Journal of Alternative and ComplementaryMedicine, 18(8), 798-804.
88. González-Molina, E., Domínguez-Perles, R., Moreno, D. A., & García-Viguera, C. (2010).Natural bioactive compounds of Citrus limon for food and health. Journal of pharmaceuticaland biomedical analysis,51(2), 327-345.
89. Gray, S., & Woolf, A. D. (2005). Citrus aurantium used for weight loss by an adolescent withanorexia nervosa. Journal of adolescent health, 37(5), 414-415.
91. Grosso, G., Galvano, F., Mistretta, A., Marventano, S., Nolfo, F., Calabrese, G., … & Scuderi,A. (2013). Red orange: experimental models and epidemiological evidence of its benefits onhuman health. Oxidative medicine and cellular longevity,2013.
92. Guadagni, D. G., Maier, V. P., & Turnbaugh, J. G. (1973). Effect of some citrus juiceconstituents on taste threshold for limonin and naringin bitterness. Journal of the Science ofFood and Agriculture,24(10), 1277-1288.
93. Guarnieri, S., Riso, P., & Porrini, M. (2007). Orange juice vs vitamin C: effect on hydrogenperoxide-induced DNA damage in mononuclear blood cells. British journal of nutrition,97(04), 639-643.
94. Guthrie, N., & Carroll, K. K. (1998). Inhibition of mammary cancer by citrus flavonoids.In Flavonoids in the Living System (pp. 227-236). Springer US.
95. Haaz, S., Fontaine, K. R., Cutter, G., Limdi, N., Perumean‐Chaney, S., & Allison, D. B. (2006).Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: anupdate. Obesity reviews, 7(1), 79-88.
96. Hansen, D. K., George, N. I., White, G. E., Pellicore, L. S., Abdel-Rahman, A., Fabricant, D.,& Food and Drug Administration. (2012). Physiological effects following administration ofCitrus aurantium for 28days in rats. Toxicology and applied pharmacology,261(3), 236-247.
journal of clinical nutrition, 67(2), 240-245.
98. Hashemi, M., Khosravi, E., Ghannadi, A., Hashemipour, M., & Kelishadi, R. (2015). Effect ofthe peels of two Citrus fruits on endothelium function in adolescents with excess weight: Atriple-masked randomized trial. Journal of Research in Medical Sciences: The Official Journalof Isfahan University of Medical Sciences, 20(8), 721.
99. Honda, Y., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Uchiumi, T., … & Sawada,Y. (2004). Effects of grapefruit juice and orange juice components on P ‐ glycoprotein ‐andMRP2 ‐mediated drug efflux. British journal of pharmacology, 143(7), 856-864.
100. Huang, Y. T., Wang, G. F., Chen, C. F., Chen, C. C., Hong, C. Y., & Yang, M. C. (1995).Fructus aurantii reduced portal pressure in portal hypertensive rats. Life sciences, 57(22), 2011-2020.
101. Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., … & Sawada, Y.(2000). Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones inadriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer letters, 160(1),21-28.
102. Jafarzadeh, M., Arman, S., & Pour, F. F. (2013). Effect of aromatherapy with orange essentialoil on salivary cortisol and pulse rate in children during dental treatment: a randomizedcontrolled clinical trial. Advanced biomedical research, 2.
103. Jayaprakasha, G. K., & Patil, B. S. (2007). In vitro evaluation of the antioxidant activities infruit extracts from citron and blood orange. Food Chemistry, 101(1), 410-418.
104. Jayaprakasha, G. K., Mandadi, K. K., Poulose, S. M., Jadegoud, Y., Gowda, G. N., & Patil, B.S. (2008). Nove triterpenoid from Citrus aurantium L. possesses chemopreventive propertiesagainst human colon cancer cells. Bioorganic & medicinal chemistry, 16(11), 5939-5951.
105. Johnston, C. S., Dancho, C. L., & Strong, G. M. (2003). Orange juice ingestion andsupplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthyadult women. Journal of the American College o Nutrition, 22(6), 519-523.
106. Jordan, S., Murty, M., & Pilon, K. (2004). Products containing bitter orange or synephrine:suspected cardiovascular adverse reactions. Canadian Medical Association. Journal, 171(8),993.
107. Kaats, G. R., Miller, H., Preuss, H. G., & Stohs, S. J. (2013). A 60 day double-blind, placebo-controlled safety studyinvolving Citrus aurantium (bitter orange) extract. Food and ChemicalToxicology, 55, 358-362.
108. Kamaraj, S., Ramakrishnan, G., Anandakumar, P., Jagan, S., & Devaki, T. (2009). Antioxidantand anticancer efficacy of hesperidin in benzo (a) pyrene induced lung carcinogenesis inmice. Investigational new drugs, 27(3), 214-222.
109. Kanaze, F. I., Gabrieli, C., Kokkalou, E., Georgarakis, M., & Niopas, I. (2003). Simultaneousreversed-phase high-performance liquid chromatographic method for the determination ofdiosmin, hesperidin and naringin in different citrus fruit juices and pharmaceuticalformulations. Journal of Pharmaceutical and Biomedical Analysis, 33(2), 243-249.
110. Kang, M., Kim, J. H., Cho, C., Chung, H. S., Kang, C. W., Kim, Y., … & Bae, H. (2007). Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart. Journal of ethnopharmacology, 111(3), 584-591.
111. Kawaii, S., Tomono, Y., Katase, E., Ogawa, K., Nonomura-Nakano, M., Nesumi, H., … &Yano, M. (2001). Quantitative study of fruit flavonoids in Citrus hybrids of King (C. nobilis)and Mukaku Kishu (C. kinokuni). Journal of agricultural and food chemistry,49(8), 3982-3986.
112. Ke, J. Y., Cole, R. M., Hamad, E. M., Hsiao, Y. H., Cotten, B. M., Powell, K. A., & Belury, M.A. (2015). Citrus flavonoid, naringenin, increases locomotor activity and reducesdiacylglycerol accumulation in skeletal muscle of obese ovariectomized mice. Molecular nutrition & food research.
113. Keevil, J. G., Osman, H. E., Reed, J. D., & Folts, J. D. (2000). Grape juice, but not orange juiceor grapefruit juice, inhibits human platelet aggregation. The Journal of nutrition, 130(1), 53-56.
114. Kelebek, H., Selli, S., Canbas, A., & Cabaroglu, T. (2009). HPLC determination of organic acids, sugars, phenolic compositions and antioxidant capacity of orange juice and orange wine made from a Turkish cv. Kozan. Microchemical Journal, 91(2), 187-192.
115. Kim, D. B., Shin, G. H., Kim, J. M., Kim, Y. H., Lee, J. H., Lee, J. S., … & Lee, O. H. (2016).Antioxidant and anti-ageing activities of citrus-based juice mixture. Food chemistry, 194, 920-927.
and MAPK signaling pathways. Phytomedicine, 22(12), 1120-1124.
117. Klimczak, I., Małecka, M., Szlachta, M., & Gliszczyńska-Świgło, A. (2007). Effect of storageon the content of polyphenols, vitamin C and the antioxidant activity of orange juices. Journalof Food Composition and Analysis, 20(3), 313-322.
118. Knekt, P., Järvinen, R., Seppänen, R., Heliövaara, M., Teppo, L., Pukkala, E., & Aromaa, A.(1997). Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.American Journal of Epidemiology, 146(3), 223-230.
Agricultural and Food Chemistry, 52(10), 2879-2886.
122. Kurowska, E. M., Borradaile, N. M., Spence, J. D., & Carroll, K. K. (2000).
hypercholesterolemia. The American journal of clinical nutrition, 72(5), 1095-1100.
cells. Phytotherapy Research, 24(S1), S15-S19.
125. Lee, D. H., Park, K. I., Park, H. S., Kang, S. R., Nagappan, A., Kim, J. A., … & An, S. J.
consumption. Journal of Clinical Oncology, JCO638254.
130. Leite, M. P., Fassin Jr, J., Baziloni, E. M., Almeida, R. N., Mattei, R., & Leite, J. R. (2008).
(HMGR) enzyme. Journal of agricultural and food chemistry, 58(19), 10768-10773.
pathway. Toxicology letters, 220(3), 219-228.
135. Lim, H., Yeo, E., Song, E., Chang, Y. H., Han, B. K., Choi, H. J., & Hwang, J. (2015).
3T3-L1 cells. Nutrition research and practice, 9(6), 599-605.
blood pressure in adults. J Health Sci Inst 30: 59–63.
functional ingredients. Food Research International, 37(8), 805-814.
cancer cell line A549 in vitro and in vivo. Cancer biology & therapy,7(6), 966-973.
139. Manach, C. 1., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., & Remesy, C. (2003).
doses of orange juice. European Journal of Clinical Nutrition,57(2), 235-242.
six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21), 5837-5843.
pertaining to cancer and inflammation. Current medicinal chemistry, 8(2), 135-153.
volunteers: a randomized controlled cross-over study. PLoS One, 6(11), e26669.
induced colon cancer by orange juice. Nutrition and cancer,36(2), 224-229.
of the Science of Food and Agriculture, 21(5), 250-253.
154. Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J. F., Scalbert, A., & Mazur, A.
crossover study in healthy volunteers. The American journal of clinical nutrition, 93(1), 73-80.
155. Morin, B., Nichols, L. A., Zalasky, K. M., Davis, J. W., Manthey, J. A., & Holland, L. J. (2008).
receptor gene transcription in HepG2 liver cells. The Journal of nutrition, 138(7), 1274-1281.
orange, lemon, bergamot and bitter orange. Phytochemistry,62(8), 1283-1289.
158. Mullen, W., Archeveque, M. A., Edwards, C. A., Matsumoto, H., & Crozier, A. (2008).
yogurt. Journal of agricultural and food chemistry, 56(23), 11157-11164.
effects on anti lipogenic activity of citrus extracts. Food chemistry, 197, 1046-1053.
activity of whole blood in healthy volunteers. Thrombosis research,132(2), 288-292.
essential oil and organic extract from the peel and kernel parts of Citrus japonica Thunb.
(kumquat) from Iran. Natural product research, 1-5.
antimicrobial activities against Salmonella spp. Journal of food science, 73(6), M264-M267.
forming risk .Clinical Journal of the American Society of Nephrology, 1(6), 1269-1274.
169. Ortuno, A., Benavente-Garcia, O., Castillo, J., Alcaraz, M., Vicente, V., & Del Rio, J. A.
(2007). Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways.
Current cancer drug targets, 7(8), 795-809.
Citrus grandis (L.) Osbeck. Evidence-Based Complementary and Alternative Medicine, 2015.
171. Patil, J. R., Jayaprakasha, G. K., Murthy, K. C., Chetti, M. B., & Patil, B. S. (2010).
pancreatic cancer cells through apoptosis. Microchemical Journal, 94(2), 108-117.
pharmaceutical and biomedical analysis, 29(6), 1113-1119.
Journal of Clinical Pharmacology, 41(10), 1059-1063.
or heat. International journal of food science & technology, 39(7), 783-791.
sinensis L. Osbeck) varieties. Free radical research, 37(6), 681-687.
orange juice. Food chemistry, 63(4), 513-518.
Journal of nutrition, 145(8), 1808-1816.
181. Rapisarda, P., Carollo, G., Fallico, B., Tomaselli, F., & Maccarone, E. (1998).
182. Rapisarda, P., Tomaino, A., Lo Cascio, R., Bonina, F., De Pasquale, A., & Saija, A. (1999).
Agricultural and Food Chemistry, 47(11), 4718-4723.
183. Riso, P., Visioli, F., Gardana, C., Grande, S., Brusamolino, A., Galvano, F., … & Porrini, M.
markers related to oxidative stress. Journal of agricultural and food chemistry, 53(4), 941-947.
184. Robards, K., & Antolovich, M. (1995). Methods for assessing the authenticity of orange juice.
A review. Analyst, 120(1), 1-28.
186. Rossato, L. G., Costa, V. M., Limberger, R. P., de Lourdes Bastos, M., & Remião, F. (2011).
antioxidant status in humans. The American journal of clinical nutrition,78(3), 454-460.
carotenoids, and other carotenoids in high-pressurized orange juice during refrigerated storage.
Journal of agricultural and food chemistry,51(3), 647-653.
during chilled storage. European Food Research and Technology, 216(1), 18-22.
of Agricultural and Food Chemistry, 53(11), 4403-4409.
and LC/MS/MS. Food chemistry, 109(3), 675-682.
Pacific journal of clinical nutrition, 11(1), 79-84.
glycerol-induced acute renal failure in rat kidney.Toxicology, 201(1), 143-151.
201. Sousa, W. R., da Rocha, C., Cardoso, C. L., Silva, D. H. S., & Zanoni, M. V. B. (2004).
voltammetric methods. Journal of Food Composition and Analysis, 17(5), 619-633.
(Bitter orange) from April 2004 to October 2009. Journal of Functional Foods, 2(4), 235-238.
spectroscopy. Journal of Luminescence, 130(2), 270-279.
These Crude Drugs by Capillary Electrophoresis. Analytical sciences, 15(10), 1017-1020.
207. Tanaka, T., Kohno, H., Murakami, M., Shimada, R., Kagami, S., Sumida, T., … & Ogawa, H.
activities of essential oil from the peel of bingtang sweet orange (Citrus sinensis Osbeck).
International journal of food science & technology,44(7), 1281-1285.
209. Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, K., Tonelli, C., … & Rapisarda, P.
Food Composition and Analysis, 19(2), 157-166.
sweet orange essential oil composition. Flavour and fragrance journal, 19(6), 544-548.
agricultural and food chemistry, 51(1), 206-210.
or in a citrus extract. The American journal of clinical nutrition, 48(3), 601-604.
in Cell Function (pp. 113-122). Springer US.
218. Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., & Pérez-Álvarez, J. (2008).
factors. The Journal of urology, 149(6), 1405-1408.
metabolism of acetylated LDL by mouse macrophages. Atherosclerosis, 178(1), 25-32.
223. Wu, S., Han, J., Feskanich, D., Cho, E., Stampfer, M. J., Willett, W. C., & Qureshi, A. A.
226. Xu, J. J., Liu, Z., Tang, W., Wang, G. C., Chung, H. Y., Liu, Q. Y., … & Li, Y. L. (2015).
rats. Journal of nutritional science and vitaminology, 54(1), 95-98.
Hong Kong. Complementary therapies in medicine, 16(3), 131-138.
La Naturopatía tiene como objeto formal de estudio la salud en su dimensión natural, que es un fenómeno complejo y por tanto exige una metodología de estudio compleja y holística. Así pues podemos decir que la Naturopatía es una disciplina que tiene como objeto integrar todas las formas de abordaje y estudio de la salud en su vertiente natural.
Hoy en día si queremos distinguir claramente entre lo que es ciencia y lo que no lo es, tenemos que comenzar estableciendo unos criterios delimitativos los cuales se dan no por un mandato extrahistórico, sino por la comunidad científica que, a lo largo de la historia, ha ido estableciendo esta diferencia por consenso científico. Por esa necesidad se ha creado este agente gestor y mediador de la ciencia Naturopática, la ciencia necesita de la objetividad, al menos en grado suficiente, para que los resultados de la investigación científica sean independientes de quien la ha llevado a cabo.
La Naturopatía se encuentra en una etapa de fructífera sistematización científica; en un proceso de elaboración sistemática, dando cohesión a un conocimiento tradicional, sin olvidar los fundamentos filosóficos que la sustentan, el conocimiento científico de la Naturopatía no es resultado de la improvisación sino que se va construyendo con la aquiescencia de la comunidad Naturopática y es por ese motivo que se debe acabar con el intrusismo, marcar las pautas y planear el criterio a seguir. El intrusismo pseudocientífico en la Naturopatía es tan frecuente como perturbador.

References: V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 v. 
 V. 
 V. 
 V.