Source: https://www.genetargeting.com/publications/
Timestamp: 2019-04-19 20:44:09+00:00

Document:
We are one of the most highly experienced and published mouse gene targeting companies in the industry. All of the publications listed on our website are specifically for gene targeted mouse models that we have created in-house for our research clients since 1998.
Kumari SS, Varadaraj K. 2019. A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0ΔC/ΔC mouse lens. Biochem Biophys Res Commun 511(3): 626-630.
Do Koo Y, Lee JS, Lee SA, Quaresma PGF, Bhat R, Haynes WG, Park YJ, Kim YB, Chung SS, Park KS. 2019. SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle. Metabolism.
Burzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH. 2019. The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin. Immunity.
Kaku H, Rothstein TL. 2019. FAIM opposes stress-induced loss of viability and blocks the formation of protein aggregates. BioRxiv.
Varadaraj K, Kumari S. 2019. Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0ΔC/ΔC Mice. Invest Ophthalmol Vis Sci 60(4): 858-867.
Sangkhae V, Nemeth E. 2019. Placental iron transport: the mechanism and regulatory circuits. Free Radic Biol Med 133: 254-261.
Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG. 2019. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep 26(9): 2289-2297 e3.
Conley SM, Stuck MW, Watson JN, Zulliger R, Burnett JL, Naash MI. 2019. Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization. Hum Mol Genet 28(3):459-475.
Vendrov AE, Sumida A, Canugovi C, Lozhkin A, Hayami T, Madamanchi NR, Runge MS. 2019. NOXA1-dependent NADPH Oxidase Regulates Redox Signaling and Phenotype of Vascular Smooth Muscle Cell During Atherogenesis. Redox Biol 21:101063.
Onaivi, ES, Qing-Rong L. 2019. Transgenic Mice. US Patent Application No.US2019/0029238 A1.
Chekuri A, Sahu B, Chavali VRM, Voronchikhina M, Hermida AS, Suk JJ, Alapati AN, Bartsch DU, Ayala-Ramirez R, Zenteno JC, Dinculescu A, Jablonski MM, Borooah S, Ayyagari R. 2019. The long-term effects of gene therapy in a novel mouse model of human MFRP-associated retinopathy. Hum Gene Ther.
Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. 2018. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. Proc Natl Acad Sci U S A 115(51): E12091-E12100.
Sato PY, Chuprun JK, Grisanti LA, Woodall MC, Brown BR, Roy R, Traynham CJ, Ibetti J, Lucchese AM, Yuan A, Drosatos K, Tilley DG, Gao E, Koch WJ. 2018. Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation. Sci Signal 11(560).
Uche UU, Piccirillo AR, Kataoka S, Grebinoski SJ, D’Cruz LM, Kane LP. 2018. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med 215(12): 3165-3179.
Salvatierra J, Diaz-Bustamante M, Meixiong J, Tierney E, Dong X, Bosmans F. 2018. A disease mutation reveals a role for NaV1.9 in acute itch. J Clin Invest 128(12): 5434-5447.
Memetimin H, Li D, Tan K, Zhou C, Liang Y, Wu Y, Wang S. 2018. Myeloid Specific Deletion of Thrombospondin 1 Protects Against Inflammation and Insulin Resistance in Long-term Diet-induced Obese Male Mice. Am J Physiol Endocrinol Metab 315(6): E1194-E1203.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR. 2018. Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron 100(4): 831-845.e7.
Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flogel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J. 2018. IL-23R Signaling Plays No Role in Myocardial Infarction. Sci Rep 8(1): 17078.
Chen X, Umeh CC, Tainsh RE, Feng DD, Maguire M, Zuo F, Rahimian M, Logan R, Wang X, Ascherio A, Macklin EA, Buys ES, Schwarzschild MA. 2018. Dissociation between urate and blood pressure in mice and in people with early Parkinson’s disease. EBioMedicine 37: 259-268.
Tharmarajah G, Eckhard U, Jain F, Marino G, Prudova A, Urtatiz O, Fuchs H, Angelis MH, Overall CM, Van Raamsdonk CD. 2018. Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase. Pigment Cell Melanoma Res 31(6): 693-707.
Li S, Franken P, Vassalli A. 2018. Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice. Sci Rep 8(1): 15474.
Zulliger R, Conley SM, Mwoyosvi ML, Al-Ubaidi MR, Naash MI. 2018. Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation. Hum Mol Gen 27(20): 3507-3518.
Bishop, TE. 2018. Multi-image color refinement with application to disparity estimation. US Patent No.10,097,805 B2.
Zhang F, Suzuki M, Kim IS, Kobayashi R, Hamada N, Sato F, Bhawal UK. 2018. Transcription factor DEC1 is required for maximal experimentally induced periodontal inflammation. J Periodontal Res 53(5): 883-893.
Defrances MC, Kane LP. 2018. Manipulation of T Cell and Mast Cell Activation by PIK3IP1. US Patent Application No.15/909322.
Keszei M, Record J, Kritikou JS, Wurzer H, Geyer C, Thiemann M, Drescher P, Brauner H, Köcher L, James J, He M, Baptista MAP, Dahlberg CIM, Biswas A, Lain S, Lane DP, Song W, Pütsep K, Vandenberghe P, Snapper SB, Westerberg LS. 2018. Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive. J Clin Invest 128(9): 4115-4131.
Kim IS, Zhang F, Bhawal UK. 2018. The Role of the Hypoxia Responsive Gene DEC1 in Periodontal Inflammation. J Hard Tissue Biol 27(3): 227-232.
Shridas P, De Beer MC, Webb NR. 2018. High-density lipoprotein inhibits serum amyloid A-mediated reactive-oxygen species generation and NLRP3 inflammasome activation. J Biol Chem 293(34): 13257-13269.
Zhang J, Yan R, Wu C, Wang H, Yang G, Zhong Y, Liu Y, Wan L, Tang A. 2018. Spermatogenesis‐associated 48 is essential for spermatogenesis in mice. Andrologia 50(6): e13027.
Ali A, Mistry BV, Ahmed HA, Abdulla R, Amer HA, Prince A, Alazami AM, Alkuraya FS, Assiri A. 2018. Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. Sci Rep 8(1): 9202.
Suetterlin P, Hurley S, Mohan C, Riegman KLH, Pagani M, Caruso A, Ellegood J, Galbusera A, Crespo-Enriquez I, Michetti C, Yee Y, Ellingford R, Brock O, Delogu A, Francis-West P, Lerch JP, Scattoni ML, Gozzi A, Fernandes C, Basson MA. 2018. Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice. Cereb Cortex 28(6): 2192-2206.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM, Corrêa SAL. 2018. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron 98(6): 1124-1132.e7.
Wan H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. 2018. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov 4(1): 26.
Alvarez MB, Xu L, Childress P, Maupin KA, Mohamad SFG, Chitteti B, Himes E, Olivos Iii DJ, Cheng YH, Conway SJ, Srour EF, Kacena MA. 2018. Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis. Stem Cell Dev 27(10): 671-682.
Hayashi H, Hess DT, Zhang R, Sugi K, Gao H, Tan BL, Bowles DE, Milano CA, Jain MK, Koch W, Stamler JS. 2018. S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. Mol Cell 70(3): 473-487.e6.
Gale Jr MJ, Schnell G, Loo Y. 2018. Methods and Compositions for Activation of Innate Immune Responses Through RIG-I Like Receptor Signaling. US Patent Application No.15/711934.
Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z. 2018. B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. JCI Insight 3(7).
Nixon AM, Meadowcroft MD, Neely EB, Snyder AM, Purnell CJ, Wright J, Lamendella R, Nandar W, Huang X, Connor JR. 2018. HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity. J Neurochem 145(4): 299-311.
Lawrence DW, Kornbluth J. 2018. Reduced inflammation and cytokine production in NKLAM deficient mice during Streptococcus pneumoniae infection. PLoS One 13(3): e0194202.
Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. 2018. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell 69(5): 757-772.
Cortes JR, Ambesi-Impiombato A, Couronne L, Quinn SA, Kim CS, da Silva Almeida AC, West Z, Belver L, Martin MS, Scourzic L, Bhagat G, Bernard OA, Ferrando AA, Palomero T. 2018. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell 33(2): 259-273.
Chang HF, Manneback S, Beck A, Ravichandran K, Krause E, Frohnweiler K, Fecher-Trost C, Schirra C, Pattu V, Flockerzi V, Rettig J. 2018. Cytotoxic granule endocytosis depends on the Flower protein. J Cell Biol 217(2): 667-683.
Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X, Li Z. 2017. Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis. J Biol Chem 44: 18091-18097.
Liu QR, Canseco-Alba A, Zhang HY, Tagliaferro P, Chung M, Dennis E, Sanabria B, Schanz N, Escosteguy-Neto JC, Ishiguro H, Lin Z, Sgro S, Leonard CM, Santos-Junior JG, Gardner EL, Egan JM, Lee JW, Xi ZX, Onaivi ES. 2017. Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference. Sci Rep 7: 17410.
Noh K, Mangala LS, Han HD, Zhang N, Pradeep S, Wu SY, Ma S, Mora E, Rupaimoole R, Jiang D, Wen Y, Shahzad MMK, Lyons Y, Cho M, Hu W, Nagaraja AS, Haemmerle M, Mak CSL, Chen X, Gharpure KM, Deng H, Xiong W, Kingsley CV, Liu J, Jennings N, Birrer MJ, Bouchard RR, Lopez-Berestein G, Coleman RL, An Z, Sood AK. 2017. Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep 21: 2785-2795.
Wischhof L, Maida S, Piazzesi A, Gioran A, Barragan Sanz K, Irsen S, Beyer M, Schultze JL, Dyer MJ, Salomoni P, Ehninger D, Nicotera P, Bano D. 2017. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Sci Rep 7: 17055.
Valnegri P, Huang J, Yamada T, Yang Y, Mejia LA, Cho HY, Oldenborg A, Bonni A. 2017. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Nat Commun 8: 1271.
Price NL, Rotllan N, Canfran-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldan A, Suárez Y, Fernández-Hernando C. 2017. Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis. Cell Rep 21: 1317-1330.
Zhao L, Wang B, Zhao X, Wu X, Zhang Q, Wei C, Shi M, Li Y, Tang W, Zhang J, Yang J, Singh SK, Jia S, Luo Y. 2017. Gain of function in the mouse model of a recurrent mutation p53N236S promotes the formation of double minute chromosomes and the oncogenic potential of p19ARF. Mol Carcinog 57(2): 147-158.
Dong S, Barnawal S, Garcia A, Gomez SS, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK. 2017. Nischarin Inhibition Alters Energy Metabolism by Activating AMP-Activated Protein Kinase. J Biol Chem 292(41):16833-16846.
Maltese M, Martella G, Imbriani P, Schuermans J, Billion K, Sciamanna G, Farook F, Ponterio G, Tassone A, Santoro M, Bonsi P, Pisani A, Goodchild RE. 2017. Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. Neurobiol Dis 108: 128-139.
Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bauerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A. 2017. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med 9: 890-905.
Genabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L. 2017. Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Sci Rep 7: 8295.
Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ. 2017. Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron 94: 1142-1154 e1146.
Watson C, Shimogori T, Puelles L. 2017. Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus. J Comp Neurol 525: 2782-2799.
Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O’Neill LA, Eltzschig HK, Masters SL, McNamee EN. 2017. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med 214: 1737-1752.
Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. 2017. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med 214(5): 1431-1452.
Kim C, Potluri P, Khalil A, Gaut D, McManus M, Compton S, Wallace DC, Yadava N. 2017. An X-chromosome linked mouse model (Ndufa1S55A) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Neurochem Int 109:78-93.
Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH, 3rd, Tait SW, Martinez J, Gale M, Jr., Loo YM, Oberst A. 2017. RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell 169: 301-313 e311.
Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. 2017. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Exp Neurol 292: 145-153.
Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT. 2017. Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci. 20: 717-726.
Zakariyah AF, Rajgara RF, Veinot JP, Skerjanc IS, Burgon PG. 2017. Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit. J Mol Cell Cardiol 105: 89-98.
Panaro BL, Flock GB, Campbell JE, Beaudry JL, Cao X, Drucker DJ. 2017. beta-Cell Inactivation of Gpr119 Unmasks Incretin-Dependence of GPR119-Mediated Glucoregulation. Diabetes 66: 1626-1635.
Vannoy CH, Zhou H, Qiao C, Xiao X, Bang AG, Lu QL. 2017. Adeno-Associated Virus-Mediated Mini-Agrin Delivery Is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I. Am J Pathol 187: 431-440.
Shin Y, Moiseyev G, Chakraborty D, Ma JX. 2017. A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol 187: 517-527.
Noguchi S, Ogawa M, Malicdan MC, Nonaka I, Nishino I. 2017. Muscle Weakness and Fibrosis Due to Cell Autonomous and Non-cell Autonomous Events in Collagen VI Deficient Congenital Muscular Dystrophy. EBioMedicine 15: 193-202.
Mierke CT, Fischer T, Puder S, Kunschmann T, Soetje B, Ziegler WH. 2017. Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices. Sci Rep 7: 42780.
Martin P, Palmer G, Rodriguez E, Seemayer CA, Palomo J, Talabot-Ayer D, Gabay C. 2017. Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses. J Immunol 198: 2916-2926.
Mao M, Kiss M, Ou Y, Gould DB. 2017. Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation. Dis Model Mech 10: 475-485.
Koukouli F, Rooy M, Tziotis D, Sailor KA, O’Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U. 2017. Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nat Med 23: 347-354.
Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. 2017. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 292: 3929-3939.
Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP. 2016. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One 11: e0155577.
Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX. 2016. T394A Mutation at the mu Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. J Neurosci 36: 10392-10403.
Subramanian VS, Lambrecht N, Lytle C, Said HM. 2016. Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. Am J Physiol Gastrointest Liver Physiol 310: G285-293.
Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT. 2016. Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators. J Physiol 594: 3271-3285.
Spencer NJ, Sorensen J, Travis L, Wiklendt L, Costa M, Hibberd T. 2016. Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPalpha-mCherry reporter mice. Am J Physiol Gastrointest Liver Physiol 311: G880-G894.
Hibberd TJ, Kestell GR, Kyloh MA, Brookes SJ, Wattchow DA, Spencer NJ. 2016. Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPalpha transgenic reporter mouse. Am J Physiol Gastrointest Liver Physiol 310: G561-573.
Shin HY, Willi M, Yoo KH, Zeng X, Wang C, Metser G, Hennighausen L. 2016. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet 48: 904-911.
Yang HQ, Foster MN, Jana K, Ho J, Rindler MJ, Coetzee WA. 2016. Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning. Am J Physiol Heart Circ Physiol 310 H1558-66.
Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y, Zhang Y. 2016. Rhythmic expression of DEC2 protein in vitro and in vivo. Biomed Rep 4: 704-710.
Pal R, Ke Q, Pihan GA, Yesilaltay A, Penman ML, Wang L, Chitraju C, Kang PM, Krieger M, Kocher O. 2016. Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Am J Physiol Heart Circ Physiol 311: H1392-H1408.
Ni J, Bao S, Johnson RI, Zhu B, Li J, Vadaparampil J, Smith CM, Campbell KN, Grahammer F, Huber TB, Xi ZX. 2016. MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes. J Biol Chem 291: 24406-24417.
Nanou E, Yan J, Whitehead NP, Kim MJ, Froehner SC, Scheuer T, Catterall WA. 2016. Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels. Proc Natl Acad Sci U S A 113: 1068-1073.
Nanou E, Sullivan JM, Scheuer T, Catterall WA. 2016. Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons. Proc Natl Acad Sci U S A 113: 1062-1067.
Nanou E, Scheuer T, Catterall WA. 2016. Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning. Proc Natl Acad Sci U S A 113: 13209-13214.
Mercier FE, Sykes DB, Scadden DT. 2016. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports 6: 985-992.
Meadowcroft MD, Wang J, Purnell CJ, Peters DG, Eslinger PJ, Neely EB, Gill DJ, Vasavada M, Ali-Rahmani F, Yang QX, Connor JR. 2016. Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice. Brain Imaging Behav 10: 1231-1242.
Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ. 2016. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest 126: 4497-4515.
Kuchmiy AA, D’Hont J, Hochepied T, Lamkanfi M. 2016. NLRP2 controls age-associated maternal fertility. J Exp Med 213: 2851-2860.
Kim MH, de Beer MC, Wroblewski JM, Charnigo RJ, Ji A, Webb NR, de Beer FC, van der Westhuyzen DR. 2016. Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice. J Lipid Res 57: 969-979.
Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA. 2016. Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron 92: 813-828.
Hathaway CK, Chang AS, Grant R, Kim HS, Madden VJ, Bagnell CR, Jr., Jennette JC, Smithies O, Kakoki M. 2016. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. Proc Natl Acad Sci U S A 113: 2218-2222.
Gao Q, Ren H, Chen M, Niu Z, Tao H, Jia Y, Zhang J, Li W. 2016. Long non-coding RNAs regulate effects of beta-crystallin B2 on mouse ovary development. Mol Med Rep 14: 4223-4231.
Fourgeaud L, Traves PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagorska A, Rothlin CV, Nimmerjahn A, Lemke G. 2016. TAM receptors regulate multiple features of microglial physiology. Nature 532: 240-244.
Cheng HY, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M, Hedrick CC. 2016. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest 126: 3236-3246.
Chen J, Gu Y, Zhang Z, Zheng W, Yang L, Huang W, Lin S, Li Y, Guo H, Luo M, Ma Q, Jiang Z, Tang A, Gui Y. 2016. Deficiency of SPATA46, a Novel Nuclear Membrane Protein, Causes Subfertility in Male Mice. Biol Reprod 95: 58.
Chakraborty D, Conley SM, Zulliger R, Naash MI. 2016. The K153Del PRPH2 mutation differentially impacts photoreceptor structure and function. Hum Mol Genet 25: 3500-3514.
Caron C, DeGeer J, Fournier P, Duquette PM, Luangrath V, Ishii H, Karimzadeh F, Lamarche-Vane N, Royal I. 2016. CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis. Sci Rep 6: 27485.
Beguelin W, Teater M, Gearhart MD, Calvo Fernandez MT, Goldstein RL, Cardenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, Shaknovich R, Elemento O, Bardwell VJ, Melnick AM. 2016. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Cancer Cell 30: 197-213.
Barriocanal-Casado E, Cueto-Urena C, Benabdellah K, Gutierrez-Guerrero A, Cobo M, Hidalgo-Gutierrez A, Rodriguez-Sevilla JJ, Martin F, Lopez LC. 2016. Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice. PLoS One 11: e0158344.
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang TY. 2016. Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression. J Biol Chem 291(12): 6232-44.
Antony AN, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, Rubin E, Csordas G, Seifert EL, Hoek JB, Hajnóczky G. 2016. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun 7: 10955.
Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB. 2016. Col4a1 mutations cause progressive retinal neovascular defects and retinopathy. Sci Rep 6: 18602.
Fujita Y, Makishima M, Bhawal UK. 2016. Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. Biochem Biophys Res Commun 269(3): 477-82.
Huang L, Urtatiz O, Van Raamsdonk CD. 2015. Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice. Cancer Res 14: 3229.
Emmanuele V, Kubota A, Garcia-Diaz B, Garone C, Akman HO, Sanchez-Gutierrez D, Escudero LM, Kariya S, Homma S, Tanji K Quinzii CM, Hirano M. 2015. Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Hum Mol Genet 24: 714-726.
Zulliger R, Conley SM, Mwoyosvi ML, Stuck MW, Azadi S, Naash MI. 2015. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS One 10: e0138508.
Zemen BG, Lai MH, Whitt JP, Khan Z, Zhao G, Meredith AL. 2015. Generation of Kcnma1fl-tdTomato, a conditional deletion of the BK channel alpha subunit in mouse. Physiol Rep 3.
Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. 2015. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science 349: 1261669.
Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP. 2015. Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med 21: 906-913.
Thakur C, Wolfarth M, Sun J, Zhang Y, Lu Y, Battelli L, Porter DW, Chen F. 2015. Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells. Oncotarget 6: 3722-3736.
Talabot-Ayer D, Martin P, Vesin C, Seemayer CA, Vigne S, Gabay C, Palmer G. 2015. Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice. J Immunol 194: 750-760.
Seehus CR, Aliahmad P, de la Torre B, Iliev ID, Spurka L, Funari VA, Kaye J. 2015. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol 16: 599-608.
Sciaccaluga M, Moriconi C, Martinello K, Catalano M, Bermudez I, Stitzel JA, Maskos U, Fucile S. 2015. Crucial role of nicotinic alpha5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. FASEB J 29: 3389-3398.
Schmidt AM, Lu W, Sindhava VJ, Huang Y, Burkhardt JK, Yang E, Riese MJ, Maltzman JS, Jordan MS, Kambayashi T. 2015. Regulatory T cells require TCR signaling for their suppressive function. J Immunol 194: 4362-4370.
Sag D, Cekic C, Wu R, Linden J, Hedrick CC. 2015. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6: 6354.
Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR. 2015. Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of “humanized” knockin mice expressing full-length or truncated VGF. Endocrinology 156: 1724-1738.
Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E, Taferner A, Unterluggauer H, Kramer C, Liedl KR, Jansen-Durr P. 2015. Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase. J Biol Chem 290: 6755-6762.
Nalbandian A, Ghimbovschi S, Wang Z, Knoblach S, Llewellyn KJ, Vesa J, Hoffman EP, Kimonis VE. 2015. Global gene expression profiling in R155H knock-in murine model of VCP disease. Clin Transl Sci 8: 8-16.
Luna-Sanchez M, Diaz-Casado E, Barca E, Tejada MA, Montilla-Garcia A, Cobos EJ, Escames G, Acuna-Castroviejo D, Quinzii CM, Lopez LC. 2015. The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol Med 7: 670-687.
Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton SR. 2015. VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism. J Neurosci 35: 10343-10356.
Joly AL, Liu S, Dahlberg CI, Mailer RK, Westerberg LS, Andersson J. 2015. Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. J Autoimmun 63: 23-30.
Jeanne M, Jorgensen J, Gould DB. 2015. Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention. Circulation 131: 1555-1565.
Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. 2015. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. J Biol Chem 290: 21443-21459.
Hillmer RE, Boisvert JP, Cucciare MJ, Dwinell MB, Joksimovic M. 2015. Generation and characterization of mice harboring a conditional CXCL12 allele. Int J Dev Biol 59: 205-209.
Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X. 2015. Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. J Biol Chem 290: 15350-15361.
Ghosh S, Geahlen RL. 2015. Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer’s Disease. EBioMedicine 2: 1785-1798.
Emmanuele V, Kubota A, Garcia-Diaz B, Garone C, Akman HO, Sanchez-Gutierrez D, Escudero LM, Kariya S, Homma S, Tanji K et al. 2015. Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Hum Mol Genet 24: 714-726.
Dincheva I, Drysdale AT, Hartley CA, Johnson DC, Jing D, King EC, Ra S, Gray JM, Yang R, DeGruccio AM, Huang C, Cravatt BF, Glatt CE, Hill MN, Casey BJ, Lee FS. 2015. FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nat Commun 6: 6395.
Dabovic B, Robertson IB, Zilberberg L, Vassallo M, Davis EC, Rifkin DB. 2015. Function of latent TGFbeta binding protein 4 and fibulin 5 in elastogenesis and lung development. J Cell Physiol 230: 226-236.
Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD. 2015. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol 195: 683-694.
Bolte C, Ren X, Tomley T, Ustiyan V, Pradhan A, Hoggatt A, Kalin TV, Herring BP, Kalinichenko VV. 2015. Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development. J Biol Chem 290: 7563-7575.
Bavik C, Henry SH, Zhang Y, Mitts K, McGinn T, Budzynski E, Pashko A, Lieu KL, Zhong S, Blumberg B, Kuksa V, Orme M, Scott I, Fawzi A, Kubota R. 2015. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One 10: e0124940.
Zhu Z, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A. 2014. Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling. Cancer Res 74: 2082-2093.
Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. 2014. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem 289: 1491-1504.
Vannoy CH, Xu L, Keramaris E, Lu P, Xiao X, Lu QL. 2014. Adeno-associated virus-mediated overexpression of LARGE rescues alpha-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein. Hum Gene Ther Methods 25: 187-196.
Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. 2014. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem 289: 19907-19916.
Tai TS, Pai SY, Ho IC. 2014. Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. PLoS One 9: e96535.
Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P. 2014. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1alpha and MED1 complex. Diabetes 63: 1519-1532.
Stuck MW, Conley SM, Naash MI. 2014. The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse. Hum Mol Genet 23: 6260-6274.
Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA. 2014. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab 19: 667-681.
Schatz O, Langer E, Ben-Arie N. 2014. Gene dosage of the transcription factor Fingerin (bHLHA9) affects digit development and links syndactyly to ectrodactyly. Hum Mol Genet 23: 5394-5401.
Oliver KH, Jessen T, Crawford EL, Chung CY, Sutcliffe JS, Carneiro AM. 2014. Pro32Pro33 mutations in the integrin beta3 PSI domain result in alphaIIbbeta3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606. Mol Pharmacol 85: 921-931.
Nakamura Y, Bryan J. 2014. Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells. PLoS One 9: e91525.
Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS. 2014. Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nat Commun 5: 4691.
Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X. 2014. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol 76: 275-282.
Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N. 2014. Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance. Development 141: 574-584.
Kohara K, Pignatelli M, Rivest AJ, Jung HY, Kitamura T, Suh J, Frank D, Kajikawa K, Mise N, Obata Y, Wickersham IR, Tonegawa S. 2014. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nat Neurosci 17: 269-279.
Jaworski M, Marsland BJ, Gehrig J, Held W, Favre S, Luther SA, Perroud M, Golshayan D, Gaide O, Thome M. 2014. Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. EMBO J 33: 2765-2781.
Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ. 2014. The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab 111: 522-532.
Gaidamakov S, Maximova OA, Chon H, Blewett NH, Wang H, Crawford AK, Day A, Tulchin N, Crouch RJ, Morse HC, 3rd, Blitzer RD, Maraia RJ. 2014. Targeted deletion of the gene encoding the La autoantigen (Sjogren’s syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol 34: 123-131.
Dubail J, Aramaki-Hattori N, Bader HL, Nelson CM, Katebi N, Matuska B, Olsen BR, Apte SS. 2014. A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis 52: 702-712.
Coleman JA, Zhu X, Djajadi HR, Molday LL, Smith RS, Libby RT, John SW, Molday RS. 2014. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. J Cell Sci 127: 1138-1149.
Cantu C, Zimmerli D, Hausmann G, Valenta T, Moor A, Aguet M, Basler K. 2014. Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes Dev 28: 1879-1884.
Bluteau G, Zhuang L, Amann R, Trueb B. 2014. Targeted disruption of the intracellular domain of receptor FgfrL1 in mice. PLoS One 9: e105210.
Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. 2014. STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet 23: 5402-5417.
Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123: 121-137.
Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. 2013. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol 183: 1559-1570.
Xu L, Lu PJ, Wang CH, Keramaris E, Qiao C, Xiao B, Blake DJ, Xiao X, Lu QL. 2013. Adeno-associated virus 9 mediated FKRP gene therapy restores functional glycosylation of alpha-dystroglycan and improves muscle functions. Mol Ther 21: 1832-1840.
Wiig H, Schroder A, Neuhofer W, Jantsch J, Kopp C, Karlsen TV, Boschmann M, Goss J, Bry M, Rakova N, Dahlmann A, Brenner S, Tenstad O, Nurmi H, Mervaala E, Wagner H, Beck FX, Müller DN, Kerjaschki D, Luft FC, Harrison DG, Alitalo K, Titze J. 2013. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest 123: 2803-2815.
Wang Y, Hekimi S. 2013. Mitochondrial respiration without ubiquinone biosynthesis. Hum Mol Genet 22: 4768-4783.
Van’t Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schutz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA Jr. 2013. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology 38: 1585-1597.
Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M. 2013. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A 110: 17023-17028.
Sen K, Mandal M. 2013. Second generation liposomal cancer therapeutics: transition from laboratory to clinic. Int J Pharm 448: 28-43.
Schlehe JS, Journel MS, Taylor KP, Amodeo KD, LaVoie MJ. 2013. The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. Neurobiol Dis 58: 57-67.
Ramirez-Ortiz ZG, Pendergraft WF, 3rd, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK. 2013. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol 14: 917-926.
Poddar D, Basu A, Baldwin WM, 3rd, Kondratov RV, Barik S, Mazumder B. 2013. An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J Immunol 190: 3600-3612.
Ota T, Doyle-Cooper C, Cooper AB, Doores KJ, Aoki-Ota M, Le K, Schief WR, Wyatt RT, Burton DR, Nemazee D. 2013. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. J Immunol 191: 3179-3185.
Nandar W, Neely EB, Unger E, Connor JR. 2013. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice. Biochim Biophys Acta 1832: 729-741.
Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. 2013. A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve 47: 260-270.
Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH. 2013. Selenoprotein N deficiency in mice is associated with abnormal lung development. FASEB J 27: 1585-1599.
Lindley LE, Briegel KJ. 2013. Generation of mice with a conditional Lbh null allele. Genesis 51: 491-497.
Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. 2013. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell 50: 172-184.
Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA, Jr., Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. 2013. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. J Biol Chem 288: 15167-15180.
Kim MH, de Beer MC, Wroblewski JM, Webb NR, de Beer FC. 2013. SAA does not induce cytokine production in physiological conditions. Cytokine 61: 506-512.
Jun JC, Kertesy S, Jones MB, Marinis JM, Cobb BA, Tigno-Aranjuez JT, Abbott DW. 2013. Innate immune-directed NF-kappaB signaling requires site-specific NEMO ubiquitination. Cell Rep 4: 352-361.
Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI. 2013. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. J Neurosci 33: 16016-16032.
Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. 2013. Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal 6: ra95.
Herring BE, Shi Y, Suh YH, Zheng CY, Blankenship SM, Roche KW, Nicoll RA. 2013. Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron 77: 1083-1096.
Hanel W, Marchenko N, Xu S, Yu SX, Weng W, Moll U. 2013. Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ 20: 898-909.
Ghosal A, Lambrecht N, Subramanya SB, Kapadia R, Said HM. 2013. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Am J Physiol Gastrointest Liver Physiol 304: G64-71.
Garcia-Corzo L, Luna-Sanchez M, Doerrier C, Garcia JA, Guaras A, Acin-Perez R, Bullejos-Peregrin J, Lopez A, Escames G, Enriquez JA, Acuña-Castroviejo D, López LC. 2013. Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum Mol Genet 22: 1233-1248.
Fu Y, Westenbroek RE, Scheuer T, Catterall WA. 2013. Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. Proc Natl Acad Sci U S A 110: 19621-19626.
Ferrer M, Cornwall G, Oko R. 2013. A population of CRES resides in the outer dense fibers of spermatozoa. Biol Reprod 88: 65.
Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM. 2013. Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol 190: 5506-5515.
de Beer MC, Wroblewski JM, Noffsinger VP, Ji A, Meyer JM, van der Westhuyzen DR, de Beer FC, Webb NR. 2013. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. J Lipids 2013: 283486.
Chen M, Zhang W, Lu X, Hoggatt AM, Gunst SJ, Kassab GS, Tune JD, Herring BP. 2013. Regulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element. J Biol Chem 288: 34647-34657.
Caruso N, Herberth B, Bartoli M, Puppo F, Dumonceaux J, Zimmermann A, Denadai S, Lebosse M, Roche S, Geng L, Magdinier F, Attarian S, Bernard R, Maina F, Levy N, Helmbacher F. 2013. Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. PLoS Genet 9: e1003550.
Cantu C, Valenta T, Hausmann G, Vilain N, Aguet M, Basler K. 2013. The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development 140: 2377-2386.
Blaeser A, Keramaris E, Chan YM, Sparks S, Cowley D, Xiao X, Lu QL. 2013. Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes. Hum Genet 132: 923-934.
Zou C, Levine EM. 2012. Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. PLoS Genet 8: e1002924.
Zinzow-Kramer WM, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed AU, Skountzou I, Ahmed R, Evavold BD, Boss JM. 2012. CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments. Genes Immun 13: 299-310.
Zhang Y, Rubin GR, Fineberg N, Huisingh C, McGwin G, Pittler SJ, Kraft TW. 2012. Age-related changes in Cngb1-X1 knockout mice: prolonged cone survival. Doc Ophthalmol 124: 163-175.
Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA. 2012. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110: e73-85.
Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V. 2012. Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration. J Neurosci 32: 12619-12629.
Yin HZ, Nalbandian A, Hsu CI, Li S, Llewellyn KJ, Mozaffar T, Kimonis VE, Weiss JH. 2012. Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice. Cell Death Dis 3: e374.
Yiannikouris F, Karounos M, Charnigo R, English VL, Rateri DL, Daugherty A, Cassis LA. 2012. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol 302: R244-251.
Yang G, Li H, Tang G, Wu L, Zhao K, Cao Q, Xu C, Wang R. 2012. Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in alpha5beta1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol 52: 677-688.
Xiang F, Cui B, Gao Q, Zhang J, Zhang J, Li W. 2012. Decreased levels of Ca(2)(+)-calmodulin-dependent protein kinase IV in the testis as a contributing factor to reduced fertility in male Crybb2(-)/(-) mice. Int J Mol Med 30: 1145-1151.
Wolkow N, Song D, Song Y, Chu S, Hadziahmetovic M, Lee JC, Iacovelli J, Grieco S, Dunaief JL. 2012. Ferroxidase hephaestin’s cell-autonomous role in the retinal pigment epithelium. Am J Pathol 180: 1614-1624.
Wang Y, Zhu S, Weisman GA, Gitlin JD, Petris MJ. 2012. Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis. PLoS One 7: e43039.
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. 2012. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A 109: 15324-15329.
Vanleeuwen JE, Penzes P. 2012. Long-term perturbation of spine plasticity results in distinct impairments of cognitive function. J Neurochem 123: 781-789.
Ukarapong S, Bao Y, Perera EM, Berkovitz GD. 2012. Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Exp Cell Res 318: 662-669.
Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA. 2012. CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2. PLoS One 7: e47740.
Shim H, Wang CT, Chen YL, Chau VQ, Fu KG, Yang J, McQuiston AR, Fisher RA, Chen CK. 2012. Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem 287: 14873-14879.
Robbins GR, Truax AD, Davis BK, Zhang L, Brickey WJ, Ting JP. 2012. Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem 287: 24294-24303.
Rateri DL, Moorleghen JJ, Knight V, Balakrishnan A, Howatt DA, Cassis LA, Daugherty A. 2012. Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 7: e51483.
Popmihajlov Z, Xu D, Morgan H, Milligan Z, Smith KA. 2012. Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. Front Immunol 3: 102.
Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, Beggs AH. 2012. Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype. Hum Mol Genet 21: 811-825.
Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. 2012. The homozygote VCP(R(1)(5)(5)H/R(1)(5)(5)H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One 7: e46308.
Miller NL, Lawson C, Chen XL, Lim ST, Schlaepfer DD. 2012. Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS One 7(5): e37830.
Makino CL, Wen XH, Olshevskaya EV, Peshenko IV, Savchenko AB, Dizhoor AM. 2012. Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One 7: e47637.
Lapointe J, Wang Y, Bigras E, Hekimi S. 2012. The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice. J Cell Biol 199: 215-224.
Konsavage WM, Jr., Jin G, Yochum GS. 2012. The Myc 3′ Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol 32: 3891-3902.
Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. 2012. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci 15: 1391-1398.
Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, Jond L, Bongiovanni M, Citi S. 2012. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci 125: 5005-5014.
Gonzalez S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J, Lluis C, Franco R, McCormick PJ, Volkow ND, Rubinstein M, Floran B, Ferré S. 2012. Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. Mol Psychiatry 17: 650-662.
Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. 2012. The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. J Neurosci 32: 9485-9498.
Eliyahu E, Shtraizent N, Shalgi R, Schuchman EH. 2012. Construction of conditional acid ceramidase knockout mice and in vivo effects on oocyte development and fertility. Cell Physiol Biochem 30: 735-748.
Cook JR, Smaldone S, Cozzolino C, del Solar M, Lee-Arteaga S, Nistala H, Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50: 635-641.
Andersson DC, Betzenhauser MJ, Reiken S, Umanskaya A, Shiomi T, Marks AR. 2012. Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. J Physiol 590: 6381-6387.
Agrawal PB, Joshi M, Savic T, Chen Z, Beggs AH. 2012. Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet 21: 2341-2356.
Zubenko GS, Hughes HB, 3rd. 2011. Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 156B: 517-531.
Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. 2011. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis 214: 58-64.
Xie Z, Cahill ME, Radulovic J, Wang J, Campbell SL, Miller CA, Sweatt JD, Penzes P. 2011. Hippocampal phenotypes in kalirin-deficient mice. Mol Cell Neurosci 46: 45-54.
Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS. 2011. Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta 1811: 508-512.
Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR. 2011. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J Immunol 186: 2127-2137.
Tsuboi K, Okamoto Y, Ikematsu N, Inoue M, Shimizu Y, Uyama T, Wang J, Deutsch DG, Burns MP, Ulloa NM, Tokumura A, Ueda N. 2011. Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochim Biophys Acta 1811: 565-577.
Templin AT, Maier B, Nishiki Y, Tersey SA, Mirmira RG. 2011. Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle 10: 1043-1049.
Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. 2011. Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages. J Immunol 187: 482-489.
Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP, 3rd, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A. 2011. Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res 108: 574-581.
Peng Y, Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z. 2011. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. J Biol Chem 286: 40331-40342.
Parent AD, Cornwall GA, Liu LY, Smith CE, Hermo L. 2011. Alterations in the testis and epididymis associated with loss of function of the cystatin-related epididymal spermatogenic (CRES) protein. J Androl 32: 444-463.
Nielsen JA, Chambers MA, Romm E, Lee LY, Berndt JA, Hudson LD. 2011. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol Cell Biochem 357: 73-81.
Ma X, Kumar M, Choudhury SN, Becker Buscaglia LE, Barker JR, Kanakamedala K, Liu MF, Li Y. 2011. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc Natl Acad Sci U S A 108: 10144-10149.
Lionnet T, Czaplinski K, Darzacq X, Shav-Tal Y, Wells AL, Chao JA, Park HY, de Turris V, Lopez-Jones M, Singer RH. 2011. A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods 8: 165-170.
Kolesnikov AV, Rikimaru L, Hennig AK, Lukasiewicz PD, Fliesler SJ, Govardovskii VI, Kefalov VJ, Kisselev OG. 2011. G-protein betagamma-complex is crucial for efficient signal amplification in vision. J Neurosci 31: 8067-8077.
Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. 2011. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther 338: 879-889.
Jimenez T, McDermott JP, Sanchez G, Blanco G. 2011. Na,K-ATPase alpha4 isoform is essential for sperm fertility. Proc Natl Acad Sci U S A 108: 644-649.
Huang S, Ling JJ, Yang S, Li XJ, Li S. 2011. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain 134: 1943-1958.
Fu Y, Westenbroek RE, Yu FH, Clark JP, 3rd, Marshall MR, Scheuer T, Catterall WA. 2011. Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. J Biol Chem 286: 12617-12626.
Chew LJ, Shen W, Ming X, Senatorov VV, Jr., Chen HL, Cheng Y, Hong E, Knoblach S, Gallo V. 2011. SRY-box containing gene 17 regulates the Wnt/beta-catenin signaling pathway in oligodendrocyte progenitor cells. J Neurosci 31: 13921-13935.
Chau KM, Cornwall GA. 2011. Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine. Biol Reprod 84: 140-152.
Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121: 2855-2862.
Bacchelli C, Buckland KF, Buckridge S, Salzer U, Schneider P, Thrasher AJ, Gaspar HB. 2011. The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice. J Allergy Clin Immunol 127: 1253-1259 e1213.
Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP. 2011. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-kappaB signaling pathways. Immunity 34: 854-865.
Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A. 2010. Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development 137: 2643-2652.
Yang G, Wu L, Bryan S, Khaper N, Mani S, Wang R. 2010. Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells. Cardiovasc Res 86: 487-495.
Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. 2010. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A 107: 19126-19131.
Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki-Hirano A, Shimogori T, Grove EA. 2010. FGF8 acts as a classic diffusible morphogen to pattern the neocortex. Development 137: 3439-3448.
Tornqvist G, Sandberg A, Hagglund AC, Carlsson L. 2010. Cyclic expression of lhx2 regulates hair formation. PLoS Genet 6: e1000904.
Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan WM, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcátegui CE, de Uzcátegui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berardinis T, Magli A, Schiavi C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty M, Jamieson RV, Møller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC. 2010. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell 140: 74-87.
Slee EA, Benassi B, Goldin R, Zhong S, Ratnayaka I, Blandino G, Lu X. 2010. Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo. Proc Natl Acad Sci U S A 107: 19479-19484.
Reidling JC, Lambrecht N, Kassir M, Said HM. 2010. Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology 138: 1802-1809.
McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ. 2010. Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res 106: 952-960.
Markert CD, Meaney MP, Voelker KA, Grange RW, Dalley HW, Cann JK, Ahmed M, Bishwokarma B, Walker SJ, Yu SX, Brown M, Lawlor MW, Beggs AH, Childers MK. 2010. Functional muscle analysis of the Tcap knockout mouse. Hum Mol Genet 19: 2268-2283.
Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD. 2010. Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem 285: 21526-21536.
Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR. 2010. Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A 107: 10274-10279.
Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. 2010. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia 12: 899-905.
Jentarra GM, Olfers SL, Rice SG, Srivastava N, Homanics GE, Blue M, Naidu S, Narayanan V. 2010. Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. BMC Neurosci 11: 19.
Howng SY, Avila RL, Emery B, Traka M, Lin W, Watkins T, Cook S, Bronson R, Davisson M, Barres BA, Popko B. 2010. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev 24: 301-311.
Herrmann R, Lobanova ES, Hammond T, Kessler C, Burns ME, Frishman LJ, Arshavsky VY. 2010. Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. J Neurosci 30: 3239-3253.
Harashima A, Guettouche T, Barber GN. 2010. Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. Genes Dev 24: 2640-2653.
Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH. 2010. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med 207: 623-635.
Geva M, Cabilly Y, Assaf Y, Mindroul N, Marom L, Raini G, Pinchasi D, Elroy-Stein O. 2010. A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter. Brain 133: 2448-2461.
Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia C, Cheema FH, Miller L, Nelson R, Paunescu TG, McKee M, Brown D, Al-Awqati Q. 2010. Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis. Proc Natl Acad Sci U S A 107: 21872-21877.
Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M. 2010. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A 107: 3799-3804.
Fairbridge NA, Dawe CE, Niri FH, Kooistra MK, King-Jones K, McDermid HE. 2010. Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Birth Defects Res A Clin Mol Teratol 88: 619-625.
Eckhardt ER, Witta J, Zhong J, Arsenescu R, Arsenescu V, Wang Y, Ghoshal S, de Beer MC, de Beer FC, de Villiers WJ. 2010. Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis. BMC Gastroenterol 10: 133.
de Beer MC, Webb NR, Wroblewski JM, Noffsinger VP, Rateri DL, Ji A, van der Westhuyzen DR, de Beer FC. 2010. Impact of serum amyloid A on high density lipoprotein composition and levels. J Lipid Res 51: 3117-3125.
Chan YM, Keramaris-Vrantsis E, Lidov HG, Norton JH, Zinchenko N, Gruber HE, Thresher R, Blake DJ, Ashar J, Rosenfeld J, Lu QL. 2010. Fukutin-related protein is essential for mouse muscle, brain and eye development and mutation recapitulates the wide clinical spectrums of dystroglycanopathies. Hum Mol Genet 19: 3995-4006.
Besnard V, Matsuzaki Y, Clark J, Xu Y, Wert SE, Ikegami M, Stahlman MT, Weaver TE, Hunt AN, Postle AD,Whitsett JA. 2010. Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice. Am J Physiol Lung Cell Mol Physiol 298: L646-659.
Bahrami J, Yusta B, Drucker DJ. 2010. ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel. Gastroenterology 138: 2447-2456.
Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, Kimonis VE. 2010. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One 5.
Zhang Y, Molday LL, Molday RS, Sarfare SS, Woodruff ML, Fain GL, Kraft TW, Pittler SJ. 2009. Knockout of GARPs and the beta-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity. J Cell Sci 122: 1192-1200.
Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA. 2009. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31: 122-130.
Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M, Yagi T. 2009. DNA polymerase delta is required for early mammalian embryogenesis. PLoS One 4: e4184.
Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. 2009. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood 114: 1355-1365.
Robling AG, Childress P, Yu J, Cotte J, Heller A, Philip BK, Bidwell JP. 2009. Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone. J Cell Physiol 219: 734-743.
Miyagoe-Suzuki Y, Masubuchi N, Miyamoto K, Wada MR, Yuasa S, Saito F, Matsumura K, Kanesaki H, Kudo A, Manya H, Endo T, Takeda S. 2009. Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech Dev 126: 107-116.
Liu J, Zhang H, Li Z, Hailemariam TK, Chakraborty M, Jiang K, Qiu D, Bui HH, Peake DA, Kuo MS, Wadgaonkar R, Cao G, Jiang XC. 2009. Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice. Arterioscler Thromb Vasc Biol 29: 850-856.
Hoover RG, Gullickson G, Kornbluth J. 2009. Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice. J Immunol 183: 6913-6921.
Festing MH, Speer MY, Yang HY, Giachelli CM. 2009. Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1. Genesis 47: 858-863.
Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R. 2009. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One 4: e5034.
Zhang J, Li J, Huang C, Xue L, Peng Y, Fu Q, Gao L, Zhang J, Li W. 2008. Targeted knockout of the mouse betaB2-crystallin gene (Crybb2) induces age-related cataract. Invest Ophthalmol Vis Sci 49: 5476-5483.
Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S et al. 2008. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322: 587-590.
Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA. 2008. Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. J Bone Miner Res 23: 1249-1256.
Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N,Kohno N, Kato Y. 2008. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol 28: 4080-4092.
Monks J, Smith-Steinhart C, Kruk ER, Fadok VA, Henson PM. 2008. Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland. Biol Reprod 78: 586-594.
Makino CL, Peshenko IV, Wen XH, Olshevskaya EV, Barrett R, Dizhoor AM. 2008. A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice. J Biol Chem 283: 29135-29143.
Maeda A, Maeda T, Golczak M, Palczewski K. 2008. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem 283: 26684-26693.
Luke Y, Zaim H, Karakesisoglou I, Jaeger VM, Sellin L, Lu W, Schneider M, Neumann S, Beijer A, Munck M, Padmakumar VC, Gloy J, Walz G, Noegel AA. 2008. Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci 121: 1887-1898.
Jordan MS, Smith JE, Burns JC, Austin JE, Nichols KE, Aschenbrenner AC, Koretzky GA. 2008. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28: 359-369.
Joesting MS, Cheever TR, Volzing KG, Yamaguchi TP, Wolf V, Naf D, Rubin JS, Marker PC. 2008. Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol 317: 161-173.
Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. 2008. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem 283: 25091-25102.
Hailemariam TK, Huan C, Liu J, Li Z, Roman C, Kalbfeisch M, Bui HH, Peake DA, Kuo MS, Cao G, Wadgaonkar R, Jiang XC. 2008. Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation. Arterioscler Thromb Vasc Biol 28: 1519-1526.
Edwin F, Patel TB. 2008. A novel role of Sprouty 2 in regulating cellular apoptosis. J Biol Chem 283: 3181-3190.
Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z. 2008. The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol Cell Biol 28: 282-292.
Arikketh D, Nelson R, Vance JE. 2008. Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice. J Biol Chem 283: 12888-12897.
Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V. 2007. Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet 16: 1661-1675.
Malicdan MC, Noguchi S, Nonaka I, Hayashi YK, Nishino I. 2007. A Gne knockout mouse expressing human GNE D176V mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy. Hum Mol Genet 16: 2669-2682.
Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME. 2007. Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. J Gen Physiol 130: 303-312.
Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. 2007. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16: 1940-1950.
Fullerton MD, Hakimuddin F, Bakovic M. 2007. Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2). Mol Cell Biol 27: 3327-3336.
Ding C, Liu Y, Wang Y, Park BK, Wang CY, Zheng P, Liu Y. 2007. Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation. PLoS One 2: e997.
Chen H, McCaffery JM, Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130: 548-562.
Baertschi S, Zhuang L, Trueb B. 2007. Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm. FEBS J 274: 6241-6253.
Anderson GR, Lujan R, Semenov A, Pravetoni M, Posokhova EN, Song JH, Uversky V, Chen CK, Wickman K, Martemyanov KA. 2007. Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. J Neurosci 27: 14117-14127.
Zhang S, Shi M, Hui CC, Rommens JM. 2006. Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality. Mol Cell Biol 26: 6656-6663.
Xu J, Lee WN, Phan J, Saad MF, Reue K, Kurland IJ. 2006. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 55: 3429-3438.
Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, Lu X. 2006. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20: 1262-1267.
Vasireddy V, Jablonski MM, Mandal MN, Raz-Prag D, Wang XF, Nizol L, Iannaccone A, Musch DC, Bush RA, Salem N, Jr., Sieving PA, Ayyagari R. 2006. Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Invest Ophthalmol Vis Sci 47: 4558-4568.
Park JM, Kohn MJ, Bruinsma MW, Vech C, Intine RV, Fuhrmann S, Grinberg A, Mukherjee I, Love PE, Ko MS, DePamphilis ML, Maraia RJ. 2006. The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol 26: 1445-1451.
Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C, Vogelstein B, St Croix B, Kinzler KW, Huso DL. 2006. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci U S A 103: 3351-3356.
McVay LD, Keilbaugh SA, Wong TM, Kierstein S, Shin ME, Lehrke M, Lefterova MI, Shifflett DE, Barnes SL, Cominelli F, Cohn SM, Hecht G, Lazar MA, Haczku A, Wu GD. 2006. Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest 116: 2914-2923.
Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. 2006. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem 281: 37697-37704.
Kim KI, Yan M, Malakhova O, Luo JK, Shen MF, Zou W, de la Torre JC, Zhang DE. 2006. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol 26: 472-479.
Faria AM, Levay A, Wang Y, Kamphorst AO, Rosa ML, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BM. 2006. The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity 24: 295-304.
Dalkilic I, Schienda J, Thompson TG, Kunkel LM. 2006. Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure. Mol Cell Biol 26: 6522-6534.
Shen J, Walsh CA. 2005. Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol 25: 3639-3647.
Chesney J, Telang S, Yalcin A, Clem A, Wallis N, Bucala R. 2005. Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality. Biochem Biophys Res Commun 331: 139-146.
Zeng Y, Takada Y, Kjellstrom S, Hiriyanna K, Tanikawa A, Wawrousek E, Smaoui N, Caruso R, Bush RA, Sieving PA. 2004. RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis. Invest Ophthalmol Vis Sci 45: 3279-3285.
Utku N, Boerner A, Tomschegg A, Bennai-Sanfourche F, Bulwin GC, Heinemann T, Loehler J, Blumberg RS, Volk HD. 2004. TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. J Immunol 173: 2342-2352.
Uda M, Ottolenghi C, Crisponi L, Garcia JE, Deiana M, Kimber W, Forabosco A, Cao A, Schlessinger D, Pilia G. 2004. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13: 1171-1181.
Sokolov M, Strissel KJ, Leskov IB, Michaud NA, Govardovskii VI, Arshavsky VY. 2004. Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. J Biol Chem 279: 19149-19156.
Ogg SL, Weldon AK, Dobbie L, Smith AJ, Mather IH. 2004. Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A 101: 10084-10089.
Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. 2004. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem 279: 10422-10432.
Muller AJ, Baker JF, DuHadaway JB, Ge K, Farmer G, Donover PS, Meade R, Reid C, Grzanna R, Roach AH, Shah N, Soler AP, Prendergast GC. 2003. Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol 23: 4295-4306.
Peterson EJ, Woods ML, Dmowski SA, Derimanov G, Jordan MS, Wu JN, Myung PS, Liu QH, Pribila JT, Freedman BD, Shimizu Y, Koretzky GA. 2001. Coupling of the TCR to integrin activation by Slap-130/Fyb. Science 293: 2263-2265.

References: Application No.15
 Application No.15
 V. 
 V. 
 V. 
 V. 
 V.