Source: https://www.tibl-journal.com/jour/article/view/853
Timestamp: 2019-04-21 15:17:54+00:00

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Аутофагия - важный иммунный механизм, определяющий устойчивость организма к внутриклеточным патогенам и, в частности, к микобактерии туберкулеза. При этом аутофагия участвует в непосредственной элиминации патогена, контроле иммунных реакций организма и поддержании внутриклеточного гомеостаза, что важно для персистенции микобактерий. Ингибирование аутофагии на ранних этапах инфицирования вирулентными штаммами микобактерий является одной из причин несостоятельности иммунного ответа, и механизмы, лежащие в основе этого процесса, рассматриваются как перспективная область для поиска патогенетически ориентированных подходов профилактики и терапии туберкулеза.
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