Source: https://www.otago.ac.nz/medical-school/people/expertise/profile/index.html?id=100
Timestamp: 2019-04-18 21:23:16+00:00

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a1 antitrypsin deficiency and liver cirrhosis / emphysema.
Antithrombin mutation and deep vein thrombosis / pulmonary embolism.
Albumin mutation and familial hyperthyroxemia.
Hypo-and afibrinogenaemia and its association with bleeding and liver cirrhosis.
Schmidt, D., & Brennan, S. O. (2007). Modified form of the fibrinogen Bβ chain (des-Gln Bβ), a potential long-lived marker of pancreatitis. Clinical Chemistry, 53(12), 2105-2111.
Metcalf, V. J., George, P. M., & Brennan, S. O. (2007). Lungfish albumin is more similar to tetrapod than to teleost albumins: Purification and characterisation of albumin from the Australian lungfish, Neoceratodus forsteri. Comparative Biochemistry & Physiology Part B, 147, 428-437.
Testro, A. G., Brennan, S. O., MacDonell, R. A. L., Hawkins, P. N., & Angus, P. W. (2007). Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein A1 Gly26Arg: Outcome of hepatorenal transplantation. Liver Transplantation, 13, 1028-1031.
Davis, R. L., & Brennan, S. O. (2007). Fibrinogen Tolaga Bay: A novel γAla341Val mutation causing hypofibrinogenaemia. Journal of Thrombosis & Haemostasis, 98, 1136-1138.
Sheen, C. R., Jewell, U. R., Morris, C. M., Brennan, S. O., Férec, C., George, P. M., Smith, M. P., & Chen, J.-M. (2007). Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. Human Mutation, 28(12), 1198-1206.
Brennan, S. O., Davis, R. L., Mosesson, M. W., Hernandez, I., Lowen, R., & Alexander, S. J. (2007). Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a γ320Asp deletion at the Ca2+ binding site. Thrombosis & Haemostasis, 98, 467-469.
Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29.
Meyer, M., Dietzel, H., Kaetzel, R., Schmidt, D., Liebscher, K., & Brennan, S. O. (2007). Fibrinogen Leipzig II (γ351Gly→Ser and γ82Ala→Gly): Hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain. Thrombosis & Haemostasis, 98(4), 903-905.
Tennent, G. A., Brennan, S. O., Stangou, A. J., O'Grady, J., Hawkins, P. N., & Pepys, M. B. (2007). Human plasma fibrinogen is synthesized in the liver. Blood, 109(5), 1971-1974.
Brennan, S. O., Mosesson, M. W., Lowen, R., & Frantz, C. (2006). Dysfibrinogenemia (fibrinogen Wilmington) due to a novel Aα chain truncation causing decreased plasma expression and impaired fibrin polymerisation. Thrombosis & Haemostasis, 96, 88-89.
Brennan, S. O., Mosesson, M. W., Lowen, R., Siebenlist, K. R., & Matsunaga, A. (2006). Hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bβ58 (3404del A) associated with thrombotic stroke in infancy. Thrombosis & Haemostasis, 95, 738-739.
Hill, M. B., Brennan, S. O., Dear, A., Strong, J., Nejim, T., & Dolan, G. (2006). Fibrinogen Nottingham II: A novel Bβ Arg264gly substitution causing hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 378-380.
Dear, A., Daly, J., Brennan, S. O., Tuckfield, A., & George, P. M. (2006). An intronic mutation within FGB (IVS1+2076 a → g) is associated with afibrinogenemia and recurrent transient ischemic attacks. Journal of Thrombosis & Haemostasis, 4, 471-472.
Meyer, M., Bergmann, F., & Brennan, S. O. (2006). Novel fibrinogen mutation ([gamma] 313 Ser->Asn) associated with hypofibrinogenemia in two unrelated families. Blood Coagulation & Fibrinolysis, 17(1), 63-67.
Sheen, C. R., Low, J., Joseph, J., Kotlyar, E., George, P. M., & Brennan, S. O. (2006). Fibrinogen Darlinghurst: Hypofibrinogenaemia caused by a W253G mutation in the gamma chain in a patient with both bleeding and thrombotic complications. Thrombosis & Haemostasis, 96, 685-687.
Brennan, S. O., Homer, V. M., Davis, R. L., Meyer, M., & George, P. M. (2006). Hypofibrinogenaemia associated with common γ82Ala→Gly mutation is not mediated by altered mRNA splicing. Thrombosis & Haemostasis, 96, 535-537.
Kruse, K. B., Dear, A., Kaltenbrun, E. R., Crum, B. E., George, P. M., Brennan, S. O., & McCracken, A. A. (2006). Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy. American Journal of Pathology, 168(4), 1299-1308.
Sheen, C. R., Brennan, S. O., Jabado, N., & George, P. M. (2006). Fibrinogen Montreal: A novel missense mutation (Aα D496N) associated with hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 231-232.
Blacklock, H. A., Case, J., Chan, T., Raizis, T., Doocey, R., Fellowes, A., … Brennan, S., & George, P. (2005). Novel sequence insertion in a Māori patient with transfusion-dependent β-thalassaemia. British Journal of Haematology, 131, 400-402.
Dear, A., Brennan, S. O., & George, P. M. (2005). Familial hypodysfibrinogenaemia associated with second occurrence of γ326 Cys→Tyr mutation. Thrombosis & Haemostasis, 93, 612-613.
Brennan, S. O., Sheen, C. R., & George, P. M. (2005). Novel γ230 Asn→Asp substitution in fibrinogen Middlemore associated hypofibrinogenaemia. Thrombosis & Haemostasis, 93, 1196-1197.
Maghzal, G. J., Brennan, S. O., & George, P. M. (2005). The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy. Thrombosis Research, 115, 293-299.
Brennan, S. O., Chan, T., Obele, M., & George, P. M. (2005). Hb Riccarton [α51(CE9)Gly→Ser]: A variant arising from a novel mutation in the α1 gene. Hemoglobin, 29(1), 61-64.
de Raucourt, E., de Mazancourt, P., Maghzal, G. J., Brennan, S. O., & Mosesson, M. W. (2005). Fibrinogen Saint-Germain II: Hypofibrinogenemia due to heterozygous γ N345S mutation. Thrombosis & Haemostasis, 94, 965-968.
Brennan, S. O., Sheen, C., Chan, T., & George, P. M. (2005). Hb Taradale [β82(EF6)Lys→Arg]: A novel mutation at a 2,3-diphosphoglycerate binding site. Hemoglobin, 29(4), 281-284.
Liew, O. W., Chong, J. P. C., Yandle, T. G., & Brennan, S. O. (2005). Preparation of recombinant thioredoxin fused N-terminal proCNP: Analysis of enterokinase cleavage products reveals new enterokinase cleavage sites. Protein Expression & Purification, 41, 332-340.
Maghzal, G. J., Brennan, S. O., Homer, V. M., & George, P. M. (2004). The molecular mechanisms of congenital hypofibrinogenaemia. Cellular & Molecular Life Sciences, 61, 1427-1438.
Dear, A., Brennan, S. O., Dempfle, C.-E., Kirschstein, W., & George, P. M. (2004). Hypofibrinogenaemia associated with a novel heterozygous γ289 Ala→Val substitution (fibrinogen Dorfen). Journal of Thrombosis & Haemostasis, 92, 1291-1295.
Dear, A., Dempfle, C. E., Brennan, S. O., Kirschstein, W., & George, P. M. (2004). Fibrinogen Mannheim II: A novel γ307 His → Tyr substitution in the γD domain causes hypofibrinogenemia. Journal of Thrombosis & Haemostasis, 2, 2194-2199.
Lefebvre, P., Velasco, P. T., Dear, A., Lounes, K. C., Lord, S. T., Brennan, S. O., … Lorand, L. (2004). Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1 G>T mutation and an AαGln328 truncation (fibrinogen Keokuk). Blood, 103(7), 2571-2576.
Florkowski, C. M., Walmsley, T. A., Brennan, S., & George, P. M. (2003). Haemoglobin Marseille-Long Island and interpretation of HbA1c: Which HbA1c result is the 'right answer'? Postgraduate Medical Journal, 79, 174-175.
Maghzal, G. J., Brennan, S., Fellowes, A. P., Spearing, R. L., & George, P. M. (2003). Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bβ255 Arg→His (Fibrinogen Merivale). Biochimica et Biophysica Acta: Proteins & Proteomics, 1645, 146-151.
Homer, V. M., Mullin, J. L., Brennan, S., Barr, A., & George, P. M. (2003). Novel Aα chain truncation (fibrinogen Perth) resulting in low expression and impaired fibrinogen polymerization. Journal of Thrombosis & Haemostasis, 1, 1245-1250.
Maghzal, G. J., Brennan, S., & George, P. M. (2003). Fibrinogen Bβ polymorphisms do not directly contribute to an altered in vitro clot structure in humans. Thrombosis & Haemostasis, 90(6), 1021-1028.
Brennan, S., Chan, T., Sheen, C., & Rae, L. (2003). Hb Lusaka [α131(H14)Ser→Phe (α1)]: A new variant found in a woman heterozygous for Hb S [β6(A3)Glu→Val]. Hemoglobin, 27(3), 177-180.
Metcalf, V., Brennan, S., & George, P. M. (2003). Using serum albumin to infer vertebrate phylogenies. Applied Bioinformatics, 2(3 Suppl.), 97-107.
Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.
Homer, V. M., Brennan, S., Ockelford, P., & George, P. M. (2002). Novel Fibrinogen truncation with deletion of Bβ chain residues 440-461 causes hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 427-431.
Brennan, S., Homer, V. M., Ockelford, P., & George, P. M. (2002). Low expression of truncated Aα Chain variant in circulating Fibrinogen. Thrombosis & Haemostasis, 88, 533-534.
Brennan, S., Maghzal, G. J., Shneider, B. L., Gordon, R., Magid, M. S., & George, P. M. (2002). Novel Fibrinogen γ375 Arg→Trp mutation (Fibrinogen Aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Hepatology, 36, 652-658.
Homer, V. M., Brennan, S., & George, P. M. (2002). Novel fibrinogen Bβ chain mutation causing hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 1066-1067.
Brennan, S., Sheen, C., & Johnson, S. (2002). Hb Manawatu [α37(C2)Pro→Leu] A new mildly unstable mutation at an invariant proline residue. Hemoglobin, 26, 389-392.
Mullin, J. L., Brennan, S., Ganly, P. S., & George, P. M. (2002). Fibrinogen Hillsborough: A Novel γ309Gly→ Asp Dysfibrinogen. Blood, 99, 3597-3610.
Homer, V. M., Brennan, S., & George, P. M. (2002). Four novel polymorphisms in the fibrinogen Aα gene. Thrombosis & Haemostasis, 87, 354-355.
Brennan, S., Potter, H. C., Kubala, L. M., Carnoutsos, S. A., & Ferguson, M. M. (2002). Hb Canterbury [beta112(G14)Cys-->Phe]: A new, mildly unstable variant. Hemoglobin, 26, 67-69.
Brennan, S. O., Wyatt, J. M., May, S. J., De Caigney, S., & George, P. M. (2001). Hypofibrinogenemia due to novel 316 Asp-Tyr substitution in the fibrinogen B beta chain. Thrombosis & Haemostasis, 85, 450-453.
Fellowes, A. P., Brennan, S., & George, P. M. (2001). Identification and characterisation of five new fibrinogen gene polymorphisms. Annals of the New York Academy of Sciences, 936, 536-541.
Brennan, S. O., Fellowes, A. P., & George, P. M. (2001). Molecular mechanisms of hypo- and afibrinogenemia. Annals of the New York Academy of Sciences, 936, 91-100.
Brennan, S. O., Wyatt, J. M., Fellowes, A. P., Dlott, J. S., Triplett, D. A., & George, P. M. (2001). γ371 Thr → Ile substitution in the fibrinogen γD domain causes hypofibrinogenaemia. Biochimica et Biophysica Acta: Protein Structure & Molecular Enzymology, 1550, 183-188.
Beard, M. E. J., Potter, H. C., Spearing, R. L., & Brennan, S. (2001). Haemoglobin Pierre-Benite, a high affinity variant associated with relative polycythaemia. Clinical Laboratory Medicine, 23, 407-409.
Hill, R. M., Brennan, S. O., & Birch, N. P. (2001). Expression, purification, and functional characterisatiion of the serine protease inhibitor neuroserpin expressed in drosophila S2 cells. Protein Expression & Purification, 22, 406-413.
Meh, D. A., Mosessen, M. W., Siebenlist, K. R., Simpson-Haidaris, P. J., Brennan, S. O., DiOrio, J. P., … Di Minno, G. (2001). Fibrinogen Naples I (β A68T) non-substrate thrombin binding capacities. Thrombosis Research, 103, 63-73.

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