Source: http://ophcj.nuph.edu.ua/article/view/ophcj.15.833
Timestamp: 2019-04-20 04:16:03+00:00

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The article is devoted to modern approaches to the creation of innovative drugs based on the so-called small molecules combined into the research system – drug design. The most common concepts and phasing of the processes of the innovative drug creation based on the concept “from idea – to a drug” are presented. The importance and role of the computer (in silico) methods in creating drugs reflected in CADD (computer assisted drug design) methods, for instance: QSAR-analysis, docking studies, molecular modeling, assessment of similarity and druglikeness, etc.) are discussed. Currently, being the permanent subject of interest of the scientific community, the approaches described are dominant in creating innovative drugs. Most of the major issues are integrated in training of pharmacy students (PharmD and MS levels in Western countries) within the discipline “Medicinal Chemistry” and are described in authoritative textbooks. At the same time, practically no attention is paid to these issues in Ukraine, and they are beyond the curricula for pharmacy students. There is the necessity of coverage of the current state of drug creation when training pharmacy students taking into account the principle of integrity of the pharmacy branch and based on the “from idea – to a drug” holistic concept mentioned. It allows to fill in the gaps between “western” and post-Soviet education systems (and/or their harmonization), especially in the context of teaching Pharmaceutical/Medicinal Chemistry. One of the possible solutions is our course “Computer Technology in Pharmacy” (for the 4th year students) covering the main milestones of drug design.
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