Source: https://www.osapublishing.org/ol/abstract.cfm?URI=ol-44-7-1588
Timestamp: 2019-04-18 13:03:50+00:00

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We report ultrashort pulse delivery through a hypocycloid-core inhibited-coupling Kagome hollow-core photonic crystal fiber (HC-PCF). Undistorted 10 fs and 6.6 nJ pulses were launched through 1 m long fiber without fiber dispersion pre-compensation and 80% efficiency. The performance of this technology for biomedical imaging is demonstrated on a biological sample by incorporating the fiber into a two-photon excited fluorescence (TPEF) laser scanning microscope (LSM) achieving a pulse width of 15 fs at the sample location. To the best of our knowledge, this is the first report on undistorted TPEF imaging in a LSM with 15 fs pulses delivered through a 1 m long Kagome HC-PCF with high throughput.
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Fig. 1. Experimental setup used for characterization of the Kagome HC fiber and for imaging. CM1 and CM2, chirped mirror (CM2 is used to compensate for dispersion introduced by the LSM); W, wedges; λ / 2 , half-wave plate; PBS, polarization beam splitter; L1-2, lenses; GS, galvanometric scanning mirrors; 4 f , scan and tube lenses in a 4 f telecentric configuration; DM1-2, dichroic mirror; BPF1-2, bandpass filters; PMT1-2, photomultiplier tubes. Inset, output spectrum of Ti:sapphire laser. A and B indicate the points where the laser pulse duration has been measured.
Fig. 2. (a) Measured spectra before (gray) and after propagation through 1 m of IC Kagome HC PCF (black dotted). (b) IAC indicating the pulse duration at the sample plane in the LSM (position B in Figure 1). (c) and (d) IAC traces from Ti:sapphire laser measured at position A in Fig. 1 without (c) and with inserted fiber (d).
Fig. 3. Mouse intestine section: merged TPEF image ( 256 × 256 pixels) showing the mucus of goblet cells (AlexaFluor350, red) and the filamentous actin prevalent in the brush border (AlexaFluor560, green).

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