Source: https://people.epfl.ch/martin.gijs
Timestamp: 2019-04-24 03:00:05+00:00

Document:
We have established a sol-gel process for the replication of three-dimensional and thin film glass nanostructures. Moreover, we have discovered a new sol-gel process to synthesize borosilicate nanoparticles.
We are working on miniaturised systems for the handling and magnetic transport of magnetic micro- and nanoparticles in microfluidic devices.
Chemists and biologists have recognized the utility of microfabricated devices for transporting and manipulating liquids on a sub-?L scale. We are active in the realisation and use of glass and polymer microfluidic chips.
We are developing microfluidic channel- and droplet-based microsystems for the handling of magnetic beads for biomedical and mixing applications. We demonstrated a variety of on-chip immuno- and cell-based- assays using magnetic beads in a microfluidic channel as substrate.
Martin A.M. Gijs received his degree in physics in 1981 from the Katholieke Universiteit Leuven, Belgium and his Ph.D. degree in physics at the same university in 1986. He joined the Philips Research Laboratories in Eindhoven, The Netherlands, in 1987. Subsequently, he has worked there on micro-and nano-fabrication processes of high critical temperature superconducting Josephson and tunnel junctions, the microfabrication of microstructures in magnetic multilayers showing the giant magnetoresistance effect, the design and realisation of miniaturised motors for hard disk applications and the design and realisation of planar transformers for miniaturised power applications. He joined EPFL in 1997. His present interests are in developing technologies for novel magnetic devices, new microfabrication technologies for microsystems fabrication in general and the development and use of microsystems technologies for microfluidic and biomedical applications in particular.
F. Gaugaz; F. Krummenacher; F. Gaugaz; M. Kayal; S. Joly et al. : A high sensitivity low-power capacitive front-end for insulin injection pens; Microelectronics Journal. 2019-03-01. DOI : 10.1016/j.mejo.2019.02.008.
H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs : Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans; Lab On A Chip. 2019-01-07. DOI : 10.1039/c8lc00863a.
V. K. Parashar; M. Gijs : Dimensional tailoring of hydrothermally grown zinc oxide nanostructures in a continuous flow micro reactor; Chemical Communications. 2018-12-04. DOI : 10.1039/c8cc05384g.
U. Rulle; Z. Tsourti; R. Casanova; K.-F. Deml; E. Verbeken et al. : Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort; Journal of Thoracic Oncology. 2018-12-01. DOI : 10.1016/j.jtho.2018.08.2034.
S. Brajkovic; B. Pelz; M.-G. Procopio; A.-L. Leblond; G. Repond et al. : Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma; Diagnostic Pathology. 2018-10-16. DOI : 10.1186/s13000-018-0757-1.
D. Migliozzi; M. A. M. Gijs; G. Huszka : Microsphere-mediated optical contrast tuning for designing imaging systems with adjustable resolution gain; Scientific Reports. 2018-10-12. DOI : 10.1038/s41598-018-33604-7.
E. Montinaro; M. Grisi; M. C. Letizia; L. Pethö; M. A. M. Gijs et al. : 3D printed microchannels for sub-nL NMR spectroscopy; PLOS ONE. 2018-05-09. DOI : 10.1371/journal.pone.0192780.
G. Huszka; M. Gijs : Turning a normal microscope into a super-resolution instrument using a scanning microlens array; SCIENTIFIC REPORTS. 2018. DOI : 10.1038/s41598-017-19039-6.
L. Dong; M. Cornaglia; G. Krishnamani; J. Zhang; L. Mouchiroud et al. : Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms; PLOS ONE. 2018. DOI : 10.1371/journal.pone.0193989.
M. Letizia; M. Cornaglia; R. Trouillon; V. Sorrentino; L. Mouchiroud et al. : Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution; MICROSYSTEMS AND NANOENGINEERING. 2018. DOI : 10.1038/s41378-018-0003-8.
H. Nguyen; L. Dupont; A. Jean; T. Gehin; Y. Chevolot et al. : Microfluidic extraction and microarray detection of biomarkers from cancer tissue slides; JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2018. DOI : 10.1088/1361-6439/aaa7a1.
N. van Loon; R. Ottenhoff; S. Kooijman; M. Moeton; S. Scheij et al. : Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice; ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018. DOI : 10.1161/ATVBAHA.118.311168.
R. Krenger; T. Lehnert; M. Gijs : Dynamic microfluidic nanocalorimetry system for measuring Caenorhabditis elegans metabolic heat; LAB ON A CHIP. 2018. DOI : 10.1039/c8lc00238j.
H. Nguyen; L. Dupont; E. Cuttaz; A. Jean; R. Trouillon et al. : Breast cancer HER2 analysis by extra-short incubation microfluidics-assisted fluorescence in situ hybridization (ESIMA FISH); MICROELECTRONIC ENGINEERING. 2018. DOI : 10.1016/j.mee.2017.12.008.
G. Huszka / M. Gijs (Dir.) : Dielectric-sphere-based microsystem for optical super-resolution imaging. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8767.
M. C. Letizia / M. Gijs (Dir.) : Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8528.
H. T. Nguyen / M. Gijs (Dir.) : Improvement of breast cancer diagnosis through microfluidics. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8459.
L. Dong / M. Gijs; T. Lehnert (Dir.) : Lab-on-a-chip technologies for manipulation and imaging of C. elegans worms and embryos. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8438.
M. C. Letizia; M. Cornaglia; G. Tranchida; R. Trouillon; M. A. M. Gijs : A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model; Integrative Biology. 2018. DOI : 10.1039/C7IB00184C.
M. Cornaglia; T. Lehnert; M. A. M. Gijs : Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans; Lab On A Chip. 2017. DOI : 10.1039/c7lc00509a.
M. Fighera / H. Shea; P. Van der Wal (Dir.) : Microengineered Electrochemical Tools for in-situ Monitoring of Marine Environment. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8151.
G. Clementini; L. Eyer; V. Ripepi; M. Marconi; T. Muraveva et al. : Testing parallaxes with local Cepheids and RR Lyrae stars; Astronomy & Astrophysics. 2017. DOI : 10.1051/0004-6361/201629925.
R. Trouillon; M. C. Letizia; K. J. Menzies; L. Mouchiroud; J. Auwerx et al. : A multiscale study of the role of dynamin in the regulation of glucose uptake; Integrative Biology. 2017. DOI : 10.1039/c7ib00015d.
S. Preston; P. K. Korhonen; L. Mouchiroud; M. Cornaglia; S. L. Mcgee et al. : Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain; Faseb Journal. 2017. DOI : 10.1096/fj.201700288R.
H. T. Nguyen; L. S. Bernier; A. M. Jean; R. Trouillon; M. Gijs : Microfluidic-assisted chromogenic in situ hybridization (MA-CISH) for fast and accurate breast cancer diagnosis; Microelectronic Engineering. 2017. DOI : 10.1016/j.mee.2017.10.007.
D. G. Dupouy; A. T. Ciftlik; M. Gijs; P. Joris ; Microfluidic network device. WO2017162617 ; EP3222351 . 2017.
M. Grisi / G. Boero (Dir.) : Broadband single-chip transceivers for compact NMR probes. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7755.
S. Brajkovic; D. G. Dupouy; L. De Leval; M. A. Gijs : Microfluidics for rapid cytokeratin immunohistochemical staining in frozen sections; Laboratory Investigation. 2017. DOI : 10.1038/labinvest.2017.49.
D. G. Dupouy; A. T. Ciftlik; D. Heintze; M. Gijs ; Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof. WO2017137422 ; EP3203413 . 2017.
F. Van Leeuwen; A. Vallenari; C. Jordi; L. Lindegren; U. Bastian et al. : Gaia Data Release 1 Open cluster astrometry: performance, limitations, and future prospects; Astronomy & Astrophysics. 2017. DOI : 10.1051/0004-6361/201730552.
G. Huszka; H. Yang; M. A. M. Gijs : Microsphere-based super-resolution scanning optical microscope; Optics Express. 2017. DOI : 10.1364/Oe.25.015079.
M. Kuhnemund; I. Hernandez-Neuta; M. I. Sharif; M. Cornaglia; M. A. M. Gijs et al. : Sensitive and inexpensive digital DNA analysis by microfluidic enrichment of rolling circle amplified single-molecules; Nucleic Acids Research. 2017. DOI : 10.1093/nar/gkw1324.
H. T. Nguyen; R. Trouillon; S. Matsuoka; M. Fiche; L. De Leval et al. : Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment in breast cancer; Laboratory Investigation. 2017. DOI : 10.1038/labinvest.2016.121.
M. Cornaglia; M. Gijs; D. Migliozzi ; Microfluidic device, system and method for the study of organisms. US2017312748 ; EP3209790 ; WO2016063199 . 2016.
H. Yang; M. Cornaglia; M. Gijs ; System for optical detection and imaging of sub-diffraction-limited nano-objects. WO2016020831 . 2016.
A. Sayah; M. A. M. Gijs : Understanding the mixing process in 3D microfluidic nozzle/diffuser systems: simulations and experiments; Journal Of Micromechanics And Microengineering. 2016. DOI : 10.1088/0960-1317/26/11/115017.
A. G. A. Brown; A. Vallenari; T. Prusti; J. H. J. De Bruijne; F. Mignard et al. : Gaia Data Release 1 Summary of the astrometric, photometric, and survey properties; Astronomy & Astrophysics. 2016. DOI : 10.1051/0004-6361/201629512.
M. L. J. Jeurissen; S. M. A. Walenbergh; T. Houben; T. Hendrikx; J. Li et al. : Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice; PLoS One. 2016. DOI : 10.1371/journal.pone.0167199.
L. Dong; M. Cornaglia; T. Lehnert; M. A. M. Gijs : On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites; Lab On A Chip. 2016. DOI : 10.1039/c6lc01005a.
D. G. Dupouy / M. Gijs (Dir.) : Microfluidic staining technology and automated image processing for fast and accurate tissue-based diagnostics. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7422.
X. Huang; V. K. Parashar; M. A. M. Gijs : Synergistic effect of carboxylic and amine ligands on the synthesis of CdSe nanocrystals; Rsc Advances. 2016. DOI : 10.1039/c6ra20812f.
H. Yang; R. Trouillon; G. Huszka; M. A. M. Gijs : Super-Resolution Imaging of a Dielectric Microsphere Is Governed by the Waist of Its Photonic Nanojet; Nano Letters. 2016. DOI : 10.1021/acs.nanolett.6b01255.
R. Trouillon; M. A. M. Gijs : Dynamic electrochemical quantitation of dopamine release from a cells-on-paper system; Rsc Advances. 2016. DOI : 10.1039/c6ra02487d.
D. J. Klionsky; K. Abdelmohsen; A. Abe; M. J. Abedin; H. Abeliovich et al. : Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); Autophagy. 2016. DOI : 10.1080/15548627.2015.1100356.
R. Padovani / M. Gijs; T. Lehnert (Dir.) : Thermal microsensors for in vitro and in vivo monitoring of chemical and biological processes. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7017.
L. Dong; M. Cornaglia; T. Lehnert; M. A. M. Gijs : Versatile size-dependent sorting of C-elegans nematodes and embryos using a tunable microfluidic filter structure; Lab On A Chip. 2016. DOI : 10.1039/c5lc01328c.
G. Palazzolo; M. Quattrocelli; J. Toelen; R. Dominici; L. Anastasia et al. : Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells; Stem Cells International. 2016. DOI : 10.1155/2016/4969430.
D. G. Dupouy; A. T. Ciftlik; M. Fiche; D. Heintze; B. Bisig et al. : Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer; Scientific Reports. 2016. DOI : 10.1038/srep20277.
M. Cornaglia; G. Krishnamani; L. Mouchiroud; V. Sorrentino; T. Lehnert et al. : Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models; Molecular Neurodegeneration. 2016. DOI : 10.1186/s13024-016-0083-6.
E. Thunell; W. van der Zwaag; H. Ögmen; G. Plomp; M. H. Herzog : Retinotopic encoding of the Ternus-Pikler display reflected in the early visual areas; Journal of Vision. 2016. DOI : 10.1167/16.3.26.
E. Thunell; G. Plomp; H. Ögmen; M. H. Herzog : EEG Correlates of Relative Motion Encoding; Brain Topography. 2016. DOI : 10.1007/s10548-015-0458-y.
R. Padovani; T. Lehnert; R. Trouillon; M. Gijs : Nanocalorimetric platform for accurate thermochemical studies in microliter volumes; RSC Advances. 2015. DOI : 10.1039/C5RA22248F.
M. Cornaglia / M. Gijs; T. Lehnert (Dir.) : Merging microfluidics and micro-array concepts: from molecular to nematode-based bioassays. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6808.
R. Trouillon; M. A. M. Gijs : Interplay between the potential waveform and diffusion layer dynamics determines the time-response of voltammetric detection in microchannels; Electrochimica Acta. 2015. DOI : 10.1016/j.electacta.2015.02.165.
A. Schmid; N. Petry; B. Walther; U. Buetikofer; W. Luginbuehl et al. : Inflammatory and metabolic responses to high-fat meals with and without dairy products in men; British Journal Of Nutrition. 2015. DOI : 10.1017/S0007114515000677.
H. Yang; M. A. M. Gijs : Optical microscopy using a glass microsphere for metrology of sub-wavelength nanostructures; Microelectronic Engineering. 2015. DOI : 10.1016/j.mee.2015.03.072.
M. Cornaglia; R. Trouillon; H. C. Tekin; T. Lehnert; M. A. M. Gijs : Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay; New Biotechnology. 2015. DOI : 10.1016/j.nbt.2015.03.008.
J. Grossenbacher / J. Brugger; R. M. Gullo (Dir.) : Development of Implantable Electrodes Based on Polymer Derived Ceramics. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-5983.
M. Cornaglia; L. Mouchiroud; A. Marette; S. Narasimhan; T. Lehnert et al. : An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging; Scientific Reports. 2015. DOI : 10.1038/srep10192.
H. Yang; M. Cornaglia; M. A. M. Gijs : Photonic Nanojet Array for Fast Detection of Single Nanoparticles in a Flow; Nano Letters. 2015. DOI : 10.1021/nl5044067.
Q. Ramadan; M. A. M. Gijs : In vitro micro-physiological models for translational immunology; Lab On A Chip. 2015. DOI : 10.1039/c4lc01271b.
B. Verbruggen; T. Toth; M. Cornaglia; R. Puers; M. A. M. Gijs et al. : Separation of magnetic microparticles in segmented flow using asymmetric splitting regimes; Microfluidics And Nanofluidics. 2015. DOI : 10.1007/s10404-014-1409-8.
P. T. Kumar; K. Vriens; M. Cornaglia; M. Gijs; T. Kokalj et al. : Digital microfluidics for time-resolved cytotoxicity studies on single non-adherent yeast cells; Lab On A Chip. 2015. DOI : 10.1039/c4lc01469c.
V. Koman / O. Martin; C. Santschi (Dir.) : Multiscattering-enhanced optical probes for biosensing. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6655.
G. H. Krishnamani; M. Cornaglia; L. Mouchiroud; M. Gijs; J. Auwerx : Long-term culture and high-resolution imaging of C. elegans using an automated microfluidic platform ; Third Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA) Symposium, Lausanne, Switzerland, March 17.
V. K. Parashar; J. B. Wacker; M. A. M. Gijs : Spherical superstructures of oxide nanoparticles for catalytic reactions in microchemical reactors; Materials Letters. 2015. DOI : 10.1016/j.matlet.201.4.10.066.
M. Atzori; A. Gijsberts; I. Kuzborskij; S. Heynen; A.-G. Mittaz Hager et al. : Characterization of a Benchmark Database for Myoelectric Movement Classification; Transactions on Neural Systems and Rehabilitation Engineering. 2015. DOI : 10.1109/TNSRE.2014.2328495.
D. G. Dupouy; A. T. Ciftlik; J. Teixidor; M. A. M. Gijs : Programming and use of Parylene C fluorescence as a quantitative on-chip reference; Rsc Advances. 2014. DOI : 10.1039/c4ra08982k.
C. Huang; Q. Ramadan; J. B. Wacker; H. C. Tekin; C. Ruffert et al. : Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells; Rsc Advances. 2014. DOI : 10.1039/c4ra09370d.
V. K. Parashar; J. B. Wacker; D. Necula; M. A. M. Gijs : A microfluidic process for on-chip formation of assemblies of oxide nanoparticles; Rsc Advances. 2014. DOI : 10.1039/c4ra06188h.
M. Cornaglia; R. Trouillon; H. C. Tekin; T. Lehnert; M. A. M. Gijs : Magnetic Particle-Scanning for Ultrasensitive Immunodetection On-Chip; Analytical Chemistry. 2014. DOI : 10.1021/ac501568g.
C. Ruffert; Q. Ramadan; M. A. M. Gijs : Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay; Microsystem Technologies-Micro-And Nanosystems-Information Storage And Processing Systems. 2014. DOI : 10.1007/s00542-013-1964-z.

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