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Timestamp: 2019-04-25 20:23:10+00:00

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Phone:���� +49-541-9692698; Fax: +49-541-9692656; E-mail: amulkid@uos.de.
comparative genomics of membrane proteins.
2006 � Doctor of Sciences (Biology), Lomonosov Moscow State University, Moscow, Russia.
2002 � Dr. rer. nat. habil. (Biophysics), University of Osnabr�ck, Germany.
1984 � Ph.D. (Biophysics), Lomonosov Moscow State University, Moscow, Russia.
1980 � MSc. (Biophysics, with honours), Lomonosov Moscow State University, Moscow, Russia.
2001 � 2004���������� Research Scientist and Principle Investigator at the Division of Biophysics, Dapartment of Biology and Chemistry, University of Osnabr�ck, Germany.
1999 - 2001���������� Research Scientist at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabr�ck, Germany.
1996 � 1999 ��������� Habilitation Fellow at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabr�ck, Germany.
1993 � 1995 ��������� Humboldt Research Fellow at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabr�ck, Germany.
1991 � ����������������� Senior Investigator (on leave from 1993), A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
1989 � 1991���������� Investigator, A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
1987 � 1989 ��������� Investigator, Department of Biophysics, School of Biology, Lomonosov Moscow State University, Moscow, Russia.
1984 � 1986 ��������� Junior Investigator, Department of Biophysics, School of Biology, Lomonosov Moscow State University, Moscow, Russia.
2005 � 2006����������������� Mercator-C3-Professorship of the Deutsche Forschungsgemeinschaft at the Department of Physics, University of Osnabr�ck, Germany.
1999 � ������������������������ Visiting Scientist at the National Center for Biotechnology Information, National Institutes of Health, Bethesda, USA (almost each year).
1991 � 1992���������� ������ EMBO Visiting Fellow at the University of Bologna, Italy.
2007 � 2013���������� Research Grant of the Deutsche Forschungsgemeinschaft on Subnanoscopic charge displacements in the ubiquinone-reducing center of the Rhodobacter capsulatus cytochrome bc1 complex (� 200000).
2008 � 2013���������� Collaborative Research Grant of the Deutsche Forschungsgemeinschaft on Nano-electrostatics of biological interfaces (� 200000 The project involves two German and three Russian research groups).
2010 � 2013���������� Grant from the �Mitotech� corporation (Russia) Investigation of the peroxidation of cardiolipin in model systems (� 35000).
2010 � 2011����� Russian government research grant for Russian scientists living abroad (2010-1.5-000-011-025) Investigation of the interaction between cardiolipin and the cytochrome bc1 complex of mammalian mitochondria (� 65000).
1996 � 1999����� Habilitation Fellowship and Research Grant from the Deutsche Forschungsgemeischaft at the University of Osnabr�ck, Germany.
1993 � 1995����� Humboldt Research Fellowship and Travel Grant at the University of Osnabr�ck, Germany.
2010�������������������� Organisation of the first meeting of the EU-COST Action CM0902: Molecular machineries for ion translocation across biomembranes (Hofheit an Taurus, Germany).
2008 ������������������� Co-organizer of the Symposium on Genomics and Evolution of the Energy-Transducing Systems (15th European Bioenergetic Conference, Dublin, Ireland).
2004 � ����������������� Invited Foreign Member, The Biophysical Society (USA).
2002 - 2006���������� Scientific Coordinator of an EC-INTAS cooperation project on Nano-scale electromechanics of the FoF1 ATP synthase and the cytochrome bc1 complex. The project involves two Russian, one German and one Italian research group.
2001 ������������������� Evaluation Expert of the European Commission, Program: Quality of Life, Subject Field: Biotechnology.
1996�������������������� Co-organizer of a Workshop of the European Science Foundation on the Structure and Function of the Cytochrome bf Complexes, Regensburg, Germany.
1994-1999������������ Scientific Coordinator of an EC-INTAS cooperation project on electrostatics of energy-transducing proteins. The project involved two Russian, one German and one French research group.
1989 ������������������� Reviewer for diverse journals including Nature, Cell, PNAS, NAR, Molecular Biology and Evolution,� EMBO Journal, J. Am. Chem. Soc., Biochemistry, FEBS Letters, Biochimica et Biophysica Acta, Applied Surface Science, Origin of Life and Evolution of Biosphere.
2011���� Invited Speaker, an Elizabeth and Frederick White Conference of the Australian Academy of Science �The Evolution of Photosynthesis and Oxygenation of the Earth�, Sydney.
2008���� Session Chairman, Invited Speaker, 15th European Bioenergetic Conference, Dublin.
2000���� Discussion Leader, Gordon Research Conference on Photosynthesis, New Hampshire.
2006 - current������ Block of lectures on Molecular Bioenergetics, School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
2002 � current ����� Supervision of PhD students at the University of Osnabr�ck, Germany (S. Klishin, M. Kozlova, K. Jahns, D. Dibrova, A. Lokhmatikov).
1995 - current������ Supervision of visiting Russian PhD students (O. Gopta, B. Feniouk, D. Knorre, F. Orekhov, M. Bozdaganyan, A. Makarov, O. Kropkacheva) during their work at the University of Osnabr�ck, Germany.
1981 � current ����� Supervision of undergraduate students first at the Lomonosov Moscow State University, Moscow, Russia and then at the University of Osnabr�ck, Germany.
Dibrova, D.V., D. A. Cherepanov, M.Y. Galperin, V. P. Skulachev, A.Y. Mulkidjanian, 2013.
Evolution of cytochrome bc complexes: from membrane electron translocases to triggers of apoptosis, Biochim Biophys Acta, accepted.
Busch K.B., G. Deckers-Hebestreit, G.T. Hanke, and A.Y. Mulkidjanian, 2013, Dynamics of bioenergetic microcompartments. Biol Chem, 394: 163�188.
Mulkidjanian A.Y., A.Y. Bychkov, D.V, Dibrova, M.Y. Galperin, and E.V. Koonin, 2012 Open questions on the origin of life at anoxic geothermal fields. Orig Life Evol Biosph, 42:507-516.
D.V. Dibrova, M. Y. Chudetsky, M. Y. Galperin, E.V. Koonin, A.Y. Mulkidjanian: 2012. The role of energy in the emergence of biology from chemistry. Orig Life Evol Biosph, 42:459-468.
Mulkidjanian, A. Y., A. Y. Bychkov, D. V. Dibrova, M. Y. Galperin, and E. V. Koonin. 2012. Origin of first cells at terrestrial, anoxic geothermal fields. Proc Natl Acad Sci USA 109: E821-E820.
Mulkidjanian AY, Lankenau D-H: LUCA - letzter gemeinsamer Vorfahre allen Lebens. In: Molek�le aus dem All? Edited by Al-Shamery K. Weinheim: Wiley-VCH-Verlag; 2011: 137-188.
Mulkidjanian AY, Cleaves HJ: Substrate. In: Encyclopedia of Astrobiology. Edited by Amils R, Quintanilla C, Cleaves HJ, Irvine WM, Pinit DL, M. V. Heidelberg: Springer; 2011: 1614.
Mulkidjanian AY: Energetics of the first life. In: Origins of Life: The Primal Self-Organisation. Edited by Egel H, Lankenau D-H, Mulkidjanian AY. Heidelberg: Springer; 2011: 1-33.
Mulkidjanian AY: Abiotic Photosynthesis. In: Encyclopedia of Astrobiology. Edited by Amils R, Quintanilla C, Cleaves HJ, Irvine WM, Pinit DL, M. V. Heidelberg: Springer; 2011: 1-3.
Mulkidjanian, A.Y., M.Y. Galperin. 2010. On the abundance of zinc in the evolutionarily old protein domains (Letter). Proc. Natl. Acad. Sci. U.S.A,107, E137.
Mulkidjanian, A.Y. 2010. Activated Q-cycle as a common mechanism for cytochrome bc1 and cytochrome b6f complexes. Biochim. Biophys. Acta, 1797:1858-1868.
Dibrova, D.V., M.Y.Galperin, A.Y. Mulkidjanian, 2010. Characterization of the N-ATPase, a distinct, laterally transferred Na+-translocating form of the bacterial F-type membrane ATPase (Discovery Note). Bioinformatics, 26:1473-1476.
Neumann S, Fuchs A, Mulkidjanian A.Y., Frishman D. 2010. Current status of membrane protein structure classification. Proteins 78,1760-1773.
Mulkidjanian AY, Galperin MY: Evolutionary origins of membrane proteins; 2010.
Mulkidjanian, A.Y., M.Y. Galperin. 2010. On the abundance of zinc in the evolutionarily old protein domains (Letter). Proc. Natl. Acad. Sci. U.S.A, in press.
Mulkidjanian, A.Y. 2010. Activated Q-cycle as a common mechanism for cytochrome bc1 and cytochrome b6f complexes. Biochim. Biophys. Acta, in press, doi:10.1016/j.bbabio.2010.07.008.
Mulkidjanian, A.Y. 2009. On the origin of life in the Zinc World: 1. Photosynthetic, porous edifices built of hydrothermally precipitated zinc sulfide (ZnS) as cradles of life on Earth. Biol. Direct 4:26.
Mulkidjanian, A.Y., M.Y. Galperin. 2009. On the origin of life in the Zinc World. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth Biol. Direct 4:27.
Mulkidjanian, A.Y., M.Y. Galperin, E.V. Koonin. 2009. Co-evolution of membranes and membrane proteins, Trends Biochem. Sci. 34, 206-215.
Kozlova, M.A., H.D. Juhnke, D.A. Cherepanov, C.R.D Lancaster, A.Y. Mulkidjanian. 2008. Proton transfer in the photosynthetic reaction center of Blastochloris viridis, FEBS Letters, 582, 238-242.
Mulkidjanian, A.Y., P. Dibrov, M.Y. Galperin. 2008. The past and present of the sodium energetics: May the sodium-motive force be with you, Biochim. Biophys. Acta, 582, 238-242.
Mulkidjanian, A.Y., M.Y. Galperin, K.S. Makarova, Y.I. Wolf, E.V. Koonin, 2008. Evolutionary primacy of sodium bioenergetics, Biol Direct 3, 13.
Mulkidjanian, A.Y., K.S. Makarova, M.Y. Galperin and E.V. Koonin. 2007. Inventing the dynamo machine: On the origin of the F-type and V-type membrane ATPases from membrane RNA/protein translocases, Nature Reviews Microbiology, 5:892-899.
Feniouk, B.A, A. Rebecci, D.Giovanni, S. Anefors, A.Mulkidjanian, W.Junge, P.Turina, and B.A.Melandri. 2007. Met23Lys mutation in subunit gamma of FOF1-ATP synthase from Rhodobacter capsulatus impairs the activation of ATP hydrolysis by protonmotive force. Biochim. Biophys. Acta, 1767:1319-1330.
Mulkidjanian, A.Y. and M. Y. Galperin. 2007. Physico-chemical and evolutionary constraints for the formation and selection of first biopolymers: Towards the consensus paradigm of the abiogenic origin of life. Chemistry and Biodiversity, 4:2003-2015.
Mulkidjanian. A.Y. 2007. Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: Introducing the activated Q-cycle. Photochem. Photobiol. Sci., 6:19-34.
Mulkidjanian, A.Y., J. Heberle, D.A. Cherepanov. 2006. Protons @ interfaces: Implications for biological energy conversion, Biochim. Biophys. Acta, 1757: 913-930.
Mulkidjanian, A.Y., E. V. Koonin, K. S. Makarova, S. L. Mekhedov, A. Sorokin, Y. I. Wolf, A. Dufresne, F. Partensky, H. Burd, D. Kaznadzey, R. Haselkorn, M. Y. Galperin 2006. The cyanobacterial genome core and the origin of photosynthesis, Proc. Natl. Acad. Sci. U.S.A., 103: 13126-13131.
Mulkidjanian, A.Y. 2006. Proton in the well and through the desolvation barrier, Biochim. Biophys. Acta, 1757: 415-427.
Mulkidjanian, A.Y., D.A. Cherepanov. 2006. Probing biological interfaces by tracing proton passage across them, Photochem. Photobiol. Sci. 5, 577-587.
Mulkidjanian, A.Y. 2005. Ubiquinol oxidation in the cytochrome bc complex: Reaction mechanism and prevention of short-circuiting, Biochim. Biophys. Acta 1709:5-34.
Mulkidjanian,A.Y., D.A.Cherepanov, and M.A.Kozlova. 2005. Ubiquinone reduction in the photosynthetic reaction center of Rhodobacter sphaeroides: Interplay between electron transfer, proton binding and the flips of quinone ring. Biochem. Soc. Trans. 33:845-850.
Mulkidjanian,A.Y., D.A.Cherepanov, J.Heberle, and W.Junge. 2005. Proton transfer dynamics at membrane/water interface and the mechanism of biological energy conversion, Biochemistry-Moscow 70:251-256.
Feniouk,B.A., A.Y.Mulkidjanian, and W.Junge. 2005. Proton slip in the ATP synthase of Rhodobacter capsulatus: induction, proton conduction, and nucleotide dependence. Biochim. Biophys. Acta 1706:184-194.
Feniouk, B.A., M.A. Kozlova, D.A. Knorre, D.A. Cherepanov, A.Y. Mulkidjanian, and W. Junge. 2004. The proton driven rotor of ATP synthase: Ohmic conductance (10 fS), and absence of voltage gating. Biophys. J. 86: 4094-4109.
Cherepanov, D.A., W. Junge, and A.Y. Mulkidjanian. 2004. Proton transfer dynamics at the membrane/water interface: Dependence on the fixed and mobile pH buffers, the geometry of membrane particles, and the interfacial potential barrier. Biophys. J. 86:665-680.
Cherepanov, D.A., B.A. Feniouk, W. Junge, and A.Y. Mulkidjanian. 2003. Low dielectric permittivity of water at the membrane interface: effect on the energy coupling mechanism in biological membranes. Biophys. J. 85:1307-1316.
Mulkidjanian, A.Y., D.A. Cherepanov, and M.Y. Galperin. 2003. Survival of the fittest before the beginning of life: selection of the first oligonucleotide-like polymers by UV light. BMC. Evol. Biol 3:12.
Nikolskaya, A.N., A.Y. Mulkidjanian, I.B. Beech, and M.Y. Galperin. 2003. MASE1 and MASE2: two novel integral membrane sensory domains. J. Mol. Microbiol Biotechnol. 5:11-16.
Feniouk, B.A., D.A. Cherepanov, N.E. Voskoboynikova, A.Y. Mulkidjanian, and W. Junge. 2002. Chromatophore vesicles of Rhodobacter capsulatus contain on average one FOF1-ATP synthase each. Biophys. J. 82:1115-1122.
Junge, W., M. Haumann, R. Ahlbrink, A. Mulkidjanian, and J. Clausen. 2002. Electrostatics and proton transfer in photosynthetic water oxidation. Philos. Trans. R. Soc. Lond B Biol Sci. 357:1407-1417.
Klishin, S.S., W. Junge, and A.Y. Mulkidjanian. 2002. Flash-induced turnover of the cytochrome bc1 complex in chromatophores of Rhodobacter capsulatus: binding of Zn2+ decelerates likewise the oxidation of cytochrome b, the reduction of cytochrome c1 and the voltage generation. Biochim. Biophys. Acta 1553:177-182.
Ahlbrink, R., Semin, B.K., Mulkidjanian, A.Y & Junge, W. 2001. Photosystem II of peas: Effects of added divalent cations of Mn, Fe, Mg, and Ca on two kinetic components of P680+-reduction in Mn-depleted core particles, Biochim. Biophys. Acta, 1506, 117-26.
Cherepanov, D.A., and Mulkidjanian, A.Y. 2001. Proton transfer in Azotobacter vinelandii ferredoxin I: Entatic Lys84 operates as elastic counterbalance for the proton-carrying Asp15, Biochim. Biophys. Acta, 1505, 179-184.
Cherepanov, D.A., Krishtalik. L.I., Mulkidjanian, A.Y., 2001. Photosynthetic electron transfer controlled by protein relaxation: Analysis by Langevin stochastic approach, Biophysical Journal, 80, 1033-1049.
Cherepanov, D.A., S.I. Bibikov, M.V. Bibikova, D.A. Bloch, L.A. Drachev, O.A. Gopta, D. Oesterhelt, A.Y. Semenov, and A.Y. Mulkidjanian. 2000. Reduction and protonation of the bound QB ubiquinone in the photosynthetic reaction centers of Rb. sphaeroides: Kinetic model based on a comparison between wild type chromatophores and the mutants with arginine substituted by isoleucine at 207 and 217 sites in the L-subunit. Biochim.Biophys.Acta, 1459, 10-34.
Mulkidjanian, A.Y. 1999b. Conformationally controlled pK-switching in membrane proteins: One more mechanism specific to the enzymatic catalysis? FEBS Lett., 463, 199-204.
Gopta, O.A., D.A. Cherepanov, W. Junge, and A.Y. Mulkidjanian. 1999. Proton transfer from the bulk to the bound ubiquinone QB of the reaction center in chromatophores of Rhodobacter sphaeroides: Retarded conveyance by neutral water. Proc.Natl.Acad.Sci.U.S.A. 96:13159-13164.
Cherepanov, D.A., A.Y. Mulkidjanian, and W. Junge. 1999. Transient accumulation of elastic energy in proton translocating ATP synthase. FEBS Lett. 449:1-6.
Feniouk, B.A., Cherepanov, D.A., Junge, W., Mulkidjanian, A.Y. 1999. ATP-synthase of Rhodobacter capsulatus: coupling of proton flow through FO to reactions in F1 under ATP synthesis and slip conditions. FEBS Letters, 445, 409-414.
Mulkidjanian, A.Y. 1999a. Photosystem II of green plants: On the role of retarded protonic relaxation in water oxidation, Biochim. Biophys. Acta, 1419, 1-6.
Haumann, M., A.Y. Mulkidjanian, W. Junge. 1999. Tyrosine-Z in oxygen-evolving photosystem II: A hydrogen-bonded tyrosinate? Biochemistry, 38, 1258-1267.
Gopta, O.A., Feniouk, B.A., Junge, W., Mulkidjanian, A.Y., 1998. The cytochrome bc1 complex of Rhodobacter capsulatus: Ubiquinol oxidation in a dimeric Q-cycle? FEBS Letters, 431, 291-296.
Mulkidjanian, A.Y., A. Hochkoeppler, D. Zannoni, L.A. Drachev, B.A. Melandri and G. Venturoli. 1998. Photosynthetic electrogenic events in native membranes of Chloroflexus aurantiacus. Flash-induced charge displacements in the acceptor side of the photosynthetic reaction center, Photosynth. Res. 56, 75-82.
Gopta, O.A., D.A. Cherepanov, A.Y. Semenov, A.Y. Mulkidjanian and D.A. Bloch. 1998. Effect of temperature and surface potential on the electrogenic proton uptake in the QB site of the Rhodobacter sphaeroides reaction center: QA-�QB-� � QAQBH2 transition, Photosynth. Res. 55, 309-316.
Ahlbrink, R., M. Haumann, M., D.A. Cherepanov, O. B�gershausen, A.Y. Mulkidjanian., and W. Junge. 1998. The function of tyrosine-Z in photosystem II of green plants: Effects of the pH, the temperature, and the H/D-isotopic ratio on the rates and extents of electron transfer, proton release and local electrochromism in the inactive and oxygen-evolving preparations, Biochemistry, 37, 1131-1142.
Gopta O.A., D.A. Bloch, D.A. Cherepanov and A.Y. Mulkidjanian. 1997. The temperature dependence of the electrogenic reaction in the QB site of the Rhodobacter sphaeroides photosynthetic reaction center: the QA-QB � QAQB- transition, FEBS Letters,412, 490-494.
Haumann, M., A.Y. Mulkidjanian, W. Junge. 1997. The electrogenicities of electron and proton transfer at the oxidizing side of photosystem II, Biochemistry, 36, 9304-9315.
Mulkidjanian, A.Y., D.A. Cherepanov, M. Haumann and W. Junge. 1996. Photosystem II of green plants: Topology of core pigments and redox cofactors as inferred from difference electrochromic spectra. Biochemistry, 35:3093-3107.
Shinkarev, V. P., L. A. Drachev, M. D. Mamedov, A. J. Mulkidjanian, A. Y. Semenov, and M. I. Verkhovsky. 1993. Effect of pH and surface potential on the rate of electric potential generation due to proton uptake by secondary quinone acceptor of reaction centers in Rhodobacter sphaeroides chromatophores. Biochim. Biophys. Acta 1144:285-294.
Semenov, A. Y., D. A. Bloch, A. R. Crofts, L. A. Drachev, R. B. Gennis, A. Y. Mulkidjanian, C. -H. Yun, V. P. Shinkarev, M. I. Verkhovsky, B. S. Kaurov, and V. P. Skulachev. 1992. Electrogenic events in chromatophores from Rhodobacter sphaeroides lacking high-potential cytochrome b of the cytochrome-bc1 complex.Biochim. Biophys. Acta 1101:166-167.
Mulkidjanian, A. Y., M. D. Mamedov, and L. A. Drachev. 1991. Slow electrogenic events in the cytochrome-bc1 complex of Rhodobacter sphaeroides: The electron transfer between cytochrome b hemes can be non-electrogenic. FEBS Letters 284:227-231.
Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky. 1990. Electrogenesis associated with proton transfer in the reaction center protein of purple bacteria Rhodobacter sphaeroides. FEBS Letters 259:324-326.
Mulkidjanian, A. Y., M. D. Mamedov, A. Y. Semenov, V. P. Shinkarev, M. I. Verkhovsky, and L. A. Drachev. 1990. Partial reversion of electrogenic reaction in ubiquinol:cytochrome c2 reductase of Rhodobacter sphaeroides under the neutral and alkaline conditions. FEBS Letters 277:127-130.
Verkhovsky, M. I., N. P. Grishanova, M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, and V. P. Shinkarev. 1990. The mechanism of interaction between the photosynthetic reaction center and cytochrome-bc1 complex in chromatophores from the non-sulphur purple bacterium Rhodobacter sphaeroides. Biokhimiya55:1202-1209.
Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, M. I. Verkhovsky, B. S. Kaurov, and V. P. Skulachev. 1989. Flash-induced electrogenic events in the photosynthetic reaction center and cytochrome-bc1 complex of Rhodobacter sphaeroides chromatophores. Biochim. Biophys. Acta973:189-197.
Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky. 1989. Transfer of ubiquinol from the reaction center to the cytochrome-bc1 complex in Rhodobacter sphaeroides chromatophores. FEBS Letters 245:43-46.
Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky. 1988. Phase II of carotenoid bandshift is mainly due to the electrogenic protonation of the secondary quinone acceptor. FEBS Letters 233:315-318.
Mulkidjanian, A. Y., V. P. Shinkarev, M. I. Verkhovsky, and B. S. Kaurov. 1986. A study of kinetic properties of the stable semiquinone of the reaction center secondary acceptor in chromatophores of non-sulfur purple bacteria. Biochim. Biophys. Acta 849:150-161.
Verkhovsky, M. I., B. S. Kaurov, A. Y. Mulkidjanian, V. D. Sled', D. A. Cherepanov, and V. P. Shinkarev. 1984. Study of photosynthetic electron transfer reactions by redox probes: Principles of dynamic redox potentiometry. Biokhimiya 49:394-402.

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