Source: https://mfint.imp.kiev.ua/en/abstract/v40/i10/1283.html
Timestamp: 2019-04-25 15:47:08+00:00

Document:
The review of works concerning a study of properties and application of new magnetic fluids containing nanocomposites of ‘superparamagnetic core–multilevel shell’ type and characterized by functionalities of biomedical nanorobots is presented. The themes of investigations are aimed at creation of novel medical theranostic remedies for targeted delivery and local complex therapy, urgently for oncology needs. The synthesized magnetic fluids and the given approaches for their magnetic diagnostics are used in creation of new native oncologic medical remedy ‘Feroplat’ that has no analogues in the world, being a conjugate of nanoparticles of magnetic fluid with cisplatin, is the standardized remedy for increase in effectiveness of chemotherapy and overcoming of medicament resistance of malignant neoplasms, prescribed for delivery of cytostatic agent immediately into tumour tissue, which ensures its maximal coming in cells and promotes increase in therapeutic effect. The obtained results develop physicochemical fundamentals for elaboration of the new-type vector systems of antitumorigenesis remedies based on magnetic fluids and are used as the method for optimization, standardization, and control of their parameters in the fabrication process. Besides, results of the work may be useful in development of new magnetocarried sorption materials for technical, technological, ecologic, and biomedical destination, medical test-systems and so on.
Key words: magnetic fluids, nanocomposites, superparamagnetic core, multilevel shell, synthesis, diagnostics, optimization, application.
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