Source: http://paganolab.org/all-research-articles.html
Timestamp: 2019-04-21 17:12:07+00:00

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Clijsters L., Hoencamp C., Calis J., Marzio A, Handgraaf S., Cuitino M., Marzluff W., Rosenberg B., Leone G., and Pagano M.
Cyclin F controls cell cycle transcriptional outputs by directing the degradation of the three activator E2Fs.
Marzio A., Puccini J., Kwon Y., Maverakis N., Arbini A., Sung P., Bar-Sagi D., and Pagano M.
The F-box domain-dependent activity of EMI1 regulates PARPi sensitivity in triple negative breast cancers.
Mol Cell 73:224-237, 2019 (see also related Preview and F1000).
Jeong Y., Simoneschi D., Keegan S., Melville D., Adler. N., Saraf A., Florens L., Washburn M., Casavotto C., Fenyo D., Cuervo A., Rossi M., and Pagano M.
The ULK1-FBXW5-SEC23B nexus controls autophagy.
eLife 7:e42253 doi: 10.7554, 2018 (see also related Insight).
Kuchay S., Saeed M., Giorgi C., Li J., Hoffmann H., Pinton P., Rice C., and Pagano M.
NS5A promotes constitutive degradation of IP3R3 to counteract apoptosis induced by hepatitis C virus.
Mavrommati I., Faedda R., Galasso G., Li J., Burdova C., Fisher R., Kessler B., Carrero Z., Guardavaccaro D., Pagano M, and D’Angiolella V.
β-TrCP- and Casein Kinase II-mediated degradation of cyclin F controls timely mitotic progression.
Rona G., Roberti D., Yin Y., Pagan J., Homer. H., Sassani E., Zeke A., Busino L., Rothenberg E., and Pagano M.
Galluzzi L., […] Pagano M., […], and Lee C.
Cell Death and Diff, 25:486-541, 2018.
Kuchay S., Giorgi C., Simoneschi D., Pagan J., Missiroli S., Saraf A., Florens L., Washburn M., Collazo A., Castillo M., Cordon-Cardo C., Sebti S., Pinton P., and Pagano M.
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumor growth.
Donato V., Bonora, M. Simoneschi D., Sartini D., Kudo Y., Saraf A., Florens L., Washburn M., Stadtfeld M., Pinton, P., and Pagano M.
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
Dankert J., Pagan J., Starostina N., Kipreos E., and Pagano M.
FEM1 proteins are ancient regulators of SLBP degradation.
Pae J., Cinalli R., Marzio, A., Pagano M., and Lehmann R.
GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.
D'Alessandro M., Beesley S., Kim J., Jones Z., Chen R., Wi J., Kyle K., Vera D., Pagano M., Nowakoski R., and Lee C.
Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.
Fehrenbacher S., daSilva I., Rairez C., Zhou Y, Cho K., Kuchay S., Shi J., Thomas. S, Pagano M., Hancock J. Bar-Sagi D., and Phillips M.
GPR31 Promotes Membrane Association of KRAS.
Dankert J., Rona G., Clijsters L., Geter P., Skaar J., Bermudez K., Sassani E., Fenyo D., Ueberheide B., Schneider R., and Pagano M.
Pagan J., Marzio A., Jones M., Saraf A., Jallepalli P., Florens L., Washburn M., and Pagano M.
Young L.M., Marzio A., Perez-Duran P., Reid D., Meredith D., Roberti, D. Star A., Rothenberg E., Ueberheide B., and Pagano M. TIMELESS forms a complex with PARP1 distinct from its complex with TIPIN and plays a role in the DNA Damage Response.
Skaar J., Ferris A., Wu X., Saraf A., Khanna K., Florens L., Washburn M., Hughes S. and Pagano M.
The Integrator complexes regulates processing-coupled termination of transcription at diverse classes of gene targets.
Horn M., Geisen C., Cermak L., Becker B., Nakamura S., Klein C., Pagano M., and Antebi A.
DRE-1/FBXO11 Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation.
Dev Cell 28: 697-710, 2014.
Choi B., Pagano, M., Huang C., and Dai W.
Cdh1, a substrate-recruiting component of the APC/C ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.
J of Biological Chemistry 289:17951-17959, 2014.
Choi B., Pagano, M., and Dai W.
Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle.
J of Biological Chemistry 289:14006-14074, 2014.
Chen X., Sahasrabuddhe A., Szankasi P., Chung F., Basrur V., Rangnekar V., Pagano M., Lim M., and Elenitoba-Johnson K.
Fbxo45-mediated degradation of the tumor suppressor Par-4 regulates cancer cell survival.
Cell Death & Diff 21: 1535-1545, 2014.
Kuchay S., Duan S., Schenkein E., Peschiaroli A., Saraf A., Florens L., Washburn M., and Pagano M.
FBXL2- and PTPL1-mediated and PTPL1-mediated degradation of p85β controls PI3K activity.
Nature Cell Biol 15:472-480, 2013.
Rossi M., Duan S., Jeong Y., Horn M., Saraf A., Florens L., Washburn M., Antebi A., and Pagano M.
Regulation of the CRL4Cdt2 ubiquitin ligase and cell cycle exitby the SCFFbxo11 ubiquitin ligase.
Jeong Y., Rossi M., Cermak L., Saraf A., Florens L., Washburn M., Sung. P, Schildkraut C., and Pagano M.
FBH1 promotes DNA double strand breakage and apopotosis in response to DNA replication stress.
J of Cell Biol 200:141-149, 2013.
Xing W., Busino L., Hinds T., Marionni S., Saifee N., Bush M., Pagano M., and Zheng N.
The SCFFbxl3 ubiquitin ligase targets circadian clock Cryptochrome proteins at their open FAD-binding pocket.
Li J., D'Angiolella V., Seeley S., Kobayashi T., Kim S., Pagano M., and Dynlacht B.
USP33 regulates centrosome biogenesis through de-ubiquitylation of a centriolar protein, CP110.
Jeong Y., Cermak L., GuiJarro M., Hernando E., and Pagano M.
FBH1 is deregulated in melanomas and protects melanocytes from transformation.
Fernández-Sáiz V., Targosz B., Lemeer S., Eichner R., Langer C., Bullinger L., Reiter C., Slotta-Huspenina J., Schroeder S., Knorn A., Kurutz J., Peschel C., Pagano M., Kuster B., and Bassermann F.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Nature Cell Biol 15:72-81, 2013.
Wu L., Grigoryan A., Li Y., Hao B., Pagano M., and Cardozo T.
Specific small molecule inhibitors of Skp2-mediated p27 degradation.
D'Angiolella V., Donato V., Jeong Y., Forrester F., Kudo, Y., Pellacani C., Saraf A., Florens L., Washburn M., and Pagano M.
Cyclin F-dependent degradation of Ribonucleotide Reductase M2 controls genome stability and DNA repair.
Busino L., Millman S., L. Scotto, Kyratsous C., Basrur V., Hoffmann A., O'Connor O., Elenitoba-Johnson K. S., and Pagano M.
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.
Nature Cell Biol, 14:375-385, 2012.
Duan S., L. Cermak, J. Pagan, M. Rossi, C. Martinengo , P. DiCelle, B. Chapyuy, M. Shipp, R. Chiarle, and Pagano M.
Kruiswijk F., Yuniati L., Magliozzi R., Bolder R., Lim R., Low T., Heck A., Pagano M., and Guardavaccaro D.
SCFβTrCP-mediated degradation of eEF2K couples protein synthesis elongation to the G2 DNA damage checkpoint.
Ping Z., Lim R., Bashir. T., Pagano M., and Guardavaccaro D.
APC/CCdh1 controls the proteasome-mediated degradation of E2F3 during cell cycle exit.
Yang F., Hu L., Chen C., Yu J., O’Connell C., Khodjakov A., Pagano M., and Dai W.
BubR1 is modified by sumoylation during mitotic progression.
J of Biological Chemistry 287:4875-4882, 2012.
Mirchandani D., Ingirani, G., Zeleniuch-Jacquotte A., Cangiarella J., Roses D., Guth A., Safyan R., Formenti S., Pagano M., and Muggia F.
Loss of p27kip1 expression in fully staged node negative breast cancer: Association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinomas.
Kim D., Zhang W., Millman S., Hwang B., Kwon S., Pagano M., Clayberger C., and Krensky A.
Fbxw7 ubiquitin ligase-meditated degradation of KLF13 prevents RANTES expression in human but not murine T lymphocytes.
Chow C., Wong N., Pagano M., Nakayama K., Nakayama K., and Lo K.W.
Role of RASSF1A in mitosis: regulation of APC/CCdc20 activity by a self-regulatory circuitry .
Duan S., Skaar J.R., Tosci A., Kanarek N., Ben-Neriah Y., and Pagano M.
mTOR generates an auto-amplification loop by triggering the βTrCP- and Ck1α-dependent degradation of DEPTOR.
Cotto-Rios X., Jones M., Busino L., Pagano M., and Huang T.
The APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
J of Cell Biology 184:177-186, 2011.
Rose A., Wang G., Hanniford D., Monni S., Tu T., Shapiro R., Berman R., Pavlick A., Pagano M., Darvishian F., Mazumdar M., Hernando E., and Osman I..
Clinical relevance of Skp2 alterations in metastatic melanoma.
Pigment Cell Melanoma Res 24:197-206, 2011.
D’Angiolella, V. Donato, S. Vijayakumar, A. Saraf, L. Florens, M. Washburn, B. Dynlacht, and Pagano M.
SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation.
Bashir T., J. K. Pagan, L Busino, and Pagano M.
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.
Cell Cycle 9: 971-974, 2010.
Kanarek N., E. Horwitz, I. Mayan, M Leshets, G. Cojocaru, M. Davis, B. Tsuberi, E. Pikarsky, M. Pagano, and Y. Ben-Neriah.
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion.
Genes & Development 24: 470-477, 2010.
Skaar J., D. Richard, A. Tosci, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and Pagano M.
J of Cell Biol 187:25-32, 2009.
Dehan E., F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and Pagano M.
βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Ge S., J. Skaar, and Pagano M.
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
Nguyen P., D. Lin, J. Lei, M. Fiorentino, E. Mueller, M. Weinstein, M. Pagano and M Loda.
The Impact of Skp2 Overexpression on Recurrence-Free Survival Following Radical Prostatectomy.
Peschiaroli A., F Scialpi, F Bernassola, M. Pagano, and G Melino.
The F-box protein Fbxo45 promotes the proteasome-dependent degradation of p73.
Mateo F., M. Vidal-Laliena, N. Canela, L. Busino, M. Martinez-Balbas, M. Pagano, N. Agell and O. Bachs.
Degradation of cyclin A is regulated by acetylation.
Hu L., S. Ibrahim, C. Liu, J. Skaar, M. Pagano, and S. Karpatkin.
Thrombin induces tumor cell cycle activation and spontaneous growth by downregulation of p27Kip1, in association with the upregulation of Skp2 and mir-222.
Bassermann F., D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and Pagano M.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint.
Frescas D., D. Guardavaccaro, S.Kuchay, H. Kato,A. Poleshko, V. Basrur, K. Elenitoba-Johnson, R. Katz, and Pagano M.
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Abbas T., U. Sivaprasad, K. Terai, V. Amador, M. Pagano, and A Dutta.
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Genes & Development 22:2496-2506, 2008.
Guardavaccaro, D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorela, A. Iavarone, S. Chang, E. Hernando, and Pagano M.
Control of chromosome stability by the βTRCP-REST-MAD2 axis.
Merluzzi S., G. Gri, V. Gattei, M. Pagano and C. Pucillo.
APE/Ref-1 makes fine tuning of CD40-induced B cell proliferation.
Zhao X., J. Heng, D. Guardavaccaro, M. Pagano, F. Guillemot, A. Iavarone and A. Lasorela.
The HECT-domain ubiquitin ligase Ureb1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Nature Cell Biol 10:643-653, 2008.
Michaelson D., W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, M. Pagano and M. Phillips.
Rac1 Accumulates in the Nucleus During the G2 Phase of the Cell Cycle and Promotes Cell Division.
J of Cell Biology 181:485-496, 2008.
Frescas D., D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and Pagano M.
The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Busino L., F. Bassermann, A. Maiolica, C Lee, S. Godinho, P. Nolan, G. Draetta and Pagano M.
SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins.
Amador V., S. Ge, P.G. Santamaria, D. Guardavaccaro and Pagano M.
APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase.
Godinho S., E. Maywood, L. Shaw, V. Tucci, A. Barnard, L. Busino, M. Pagano, R. Kendall, M. Quwailid, R. Romero, J. O'Neill, J. Chesham, D. Brooker, Z. Lalanne, S. Hastings and P. Nolan.
The after hours mutant reveals a role for FBXL3 in determining mammalian circadian period.
Kitajima S., Y. Kudo, I. Ogawa, M. Tatsuka, H. Kawai, M. Pagano, T. Takata.
Constitutive phosphorylation of Aurora-A on Ser51 induces its stabilization and consequent overexpression in cancer.
Peng Y., C. Li, F. Chen, Z.Wang, M. Ligr, J. Melamed, J. Wei, W. Gerald, M.
Pagano, M. Garabdian and P. Lee.
Stimulation of prostate cancer cell proliferation and invasion by the Androgen receptor co-activator ARA70.
Am J of Path 172:225-235, 2007.
Fielenbach N., D. Guardavaccaro, K. Neubert, T. Chan, D. Li, Q. Feng, H. Hutter, M. Pagano and A. Antebi.
DRE-1, an evolutionarily conserved F-box protein that regulates C. elegans developmental age.
Bassermann F., C. vonKlitzing, A. Illert, S. Munch, S. Morris, M. Pagano, C. Peschel and J. Duyster.
Multisite phosphorylation of Nipa at G2/M involves cyclin B1/Cdk1.
J of Biological Chemistry 282:15965-15972, 2007.
Xu S., M. Abbasian, P. Patel, K. Jensen, C. Lombardo, B. Cathers, W. Xie, F. Mercurio, M. Pagano, D. Giegel and S. Cox.
Substrate recognition and ubiquitination of SCFSkp2/Cks1 E3 ligase.
Journal of Biological Chemistry 282:15462-15470, 2007.
Dorrello N. V., A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman and Pagano M.
S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Peschiaroli A., N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N. Sherman and Pagano M..
SCFβTRCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Utku Y., E. Dehan, O. Ouerfelli, F. Piano, R. N. Zuckermann, M. Pagano and K. Kirshenbaum.
Ji P., L. Goldin, H. Ren, D. Sun, D Guardavaccaro, M. Pagano and L. Zhu.
Skp2 contains a novel cyclin a binding domain that directly protects cyclin A from inhibition by p27.
J of Biological Chemistry 281:24058-24069, 2006.
Bloom J., A. Peschiaroli, G. DeMartino and Pagano M..
Modification of Cul1 regulates its association with proteasomal subunits.
Lasorela A., J. Stegmueller, G. Rothschild, D. Guardavaccaro, L. delaTorre, M. Pagano, A Bonni and A. Iavarone.
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.
Block K., S. Appikonda, A. Horng-Ru Lin, J. Bloom, M. Pagano, and R. Yew.
The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.
Hao B., N. Zheng, B. Schulman, G. Wu, J. Miller, M. Pagano, and N. Pavletich.
Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase.
Benmamar R. and Pagano M.
Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase.
Ji P., H. Jiang, K. Rekhtman, J. Bloom, M. Ichetovkin, M. Pagano and L Zhu.
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.
Kitajima S., Y Kudo, I. Ogawa, T. Bashir, M. Kitagawa, M. Miyauchi, M. Pagano and T. Takata.
Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation.
Am J Pathol 165: 2147-2155, 2004.
Kudo Y., D. Guardavaccaro, P. Santamaria, R. Nasu, E. Latres, R. Bronson, L. Yamasaki and Pagano M..
Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis.
Mol Cell Biol 24:8184-8194, 2004.
Bernassola F., P. Salomoni, A. Oberst, C. Di Como, M. Pagano, G. Melino and P. Padolffi.
Ubiquitin-dependent degradation of p73 is Inhibited by PML.
J Exp Med 99:1545-1557, 2004.
Moshe Y., J. Boulaire, M. Pagano and H. Hershko.
Role of Polo-like kinase in the degradation of Emi1, a regulator of the Anaphase Promoting Complex/Cyclosome.
Proc Natl Acad Sci USA 101:7937-7942, 2004.
Shapira M., O. Ben-Izhak, B. Bishara, B. Futerman, I. Minkov, M. Krausz, M. Pagano, and D. Hershko.
Alterations in the expression of the cell cycle regulatory protein Cks1 in colorectal carcinoma.
Bashir T., V. Dorrello, V. Amador, D. Guardavaccaro and Pagano M.
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase.
Bloom J., V. Amador, F. Bartolini, G. DeMartino and Pagano M.
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.
Busino L., M. Donzelli, M. M. Chiesa, D. Guardavaccaro, D. Ganoth, N. V. Dorrello, A. Hershko, M. Pagano and G. Draetta.
Ubiquitin-mediated degradation of Cdc25A by βTrcp during S phase and in response to DNA damage.
Bornstein G., J. Bloom, D. Sitri, K.I. Nakayama, M. Pagano, and A. Hershko.
Role of the SCFSkp2 ligase in the degradation of p21Cip1 In S phase.
J of Biological Chemistry 278: 25752-25757, 2003.
Guardavaccaro D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin, P. Jackson, Yamasaki L. and Pagano M.
Control of meiotic and mitotic progression by the F-box protein βTrcp1 in vivo.
Dev. Cell 4: 799-812, 2003.
Drobnjak M., J. Melamed, T. Taneja, K. Melzer, R. Wieczorek, B. Levinson, A. Zeleniuch, D. Polsky, J. Ferrara, R. Perez-Soler, C. Cordon-Cardo, M. Pagano and I. Osman.
Altered expression of p27 and Skp2 proteins in prostate cancer of african-american patients.
Clin. Cancer Research 9:2613-2619, 2003.
McAllister S., M. Becker-Hapak, G. Pintucci, M. Pagano and S. F. Dowdy.
Novel p27 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions.
Mol Cell Biol 23:216-228, 2003.
D. Sitri, M. A. Seeliger, T. K. Ko, D. Ganoth, L. S. Itzhaki, M. Pagano and A. Hershko.
Three different binding sites of Cks1 are required for p27-ubiquitin ligation.
J of Biological Chemistry 277:42233-42240, 2002.
Donzelli M., M. Squatrito, D. Ganoth, Hershko, A., M. Pagano and G. F. Draetta.
Dual Mode of Degradation of Cdc25 A phosphatase.
Piva R., J. Liu, R. Chiarle, A. Podda, M. Pagano, and G. Ingirani.
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Mol Cell Biol 22:8375-8387, 2002.
Signoretti S., L. Dimarcotullio, A. Richardson, S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda and Pagano M.
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.
J of Clinical Investigation 110:633-641, 2002.
Zheng N., B. Schulman, J. Miller, P. Wang, P. Jeffrey, C. Chu, D. M. Koepp, S. Elledge, M. Pagano, R. Conaway, J. Conaway, J. Harperr and N. Pavletich.
Structure of the Cul1-Rbx1-Skp1-F-box-Skp2 SCF Ubiquitin Ligase Complex.
Chiarle R., F. Yan, R. Piva, H. Boggino, J, Skolnik, D. Novero, G. Palestro, C. DeWolf, M. Chilosi, M. Pagano, and G. Ingirani.
Skp2 expression in non-Hodgking lymphomas inversely correlates with p27 expression and defines cells in S-phase.
Am J Pathol 160: 1457-1466, 2002.
Cheng H., C. Cenciarelli, Z. Shao, M. Vidal, W. Parks, M. Pagano and C. Cheng-Mayer.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Current Biology 11: 1771-1775, 2001.
Rodier G., A. Montagnoli, L. DiMarcotullio, P. Coulombe, G. Draetta, M. Pagano and S. Meloche.
p27 cytoplasmic localization is regulated by phosphorylation on serine 10 and is not a prerequisite for its proteolysis.
EMBO J 20: 6672-6682, 2001.
Spiegelman V. S., P. Stavropoulos, E. Latres, M. Pagano, H. Furneaux, T. J. Slaga, and S. Y. Fuchs.
Induction of β-TrCP/Fbw1a by JNK signaling and its role in the activation of NF-kB.
J of Biological Chemistry 29: 27152-27158, 2001.
Carrano A. C. and Pagano M.
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.
J of Cell Biology 153: 1381-1389, 2001.
Desalle L., E. Latres, D. Lin, E. Graner, A. Montagnoli, R. Baker, M. Pagano and M. Loda.
The De-ubiquitinating enzyme Unp interacts with the Retinoblastoma protein.
Ganoth D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano and A. Hershko.
The cell cycle regulatory protein Cks1 is required for the SCFSkp2-mediated ubiquitinylation of p27.
Nature Cell Biol 3: 321-324, 2001.
Latres E., R. Chiarle, B. Schulman, N. Pavletich, A. Pellicer, G. Ingirani and Pagano M.
Role of the F-box protein Skp2 in lymphomagenesis.
Proc Natl Acad Sci USA 98: 2515-2520, 2001.
Hershko D., G. Bornstein, O. Ben-Izhak, A. Carrano, M. Pagano, M. Krausz, and A. Hershko.
Inverse relationship between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.
Schulman B., A.C. Carrano, P. Jeffrey, Z. Bowen, E. Kinnucan, M. Finnin, S. Elledge, W. Harper, M. Pagano and N. Pavletich.
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Cangi M., B. Cukor, P. Soung, S. Signoretti, G. Moreira, M. Ranashinge, B. Cady, M. Pagano and M. Loda.
Role of the Cdc25A phosphatase in human breast cancer.
J of Clinical Investigation 106: 753-761, 2000.
Spiegelman V., T. Slaga, M. Pagano, T. Minamoto, Z. Ronai and S. Y. Fuchs.
Wnt/b-catenin signaling induces the expression and activity of β-TrCP ubiquitin ligase receptor.
Mol Cell 5: 877-882, 2000.
Chiaur D. S., S. Murthy, C. Cenciarelli, M. Loda, G. Ingirani, W. Parks, D. Demetrick, and Pagano M.
Five human genes encoding FBP: Chromosomal mapping and analysis of gross mutations in human tumors.
Cytogenetics and Cell Genetics 88: 255-258, 2000.
Chilosi M., R. Chiarle, M. Lestani, F. Menestrina, L. Montagna, A. Ambrosetti, G. Prolla, G. Pizzolo, C. Doglioni, R. Piva, M. Pagano, and G. Ingirani.
Low expression of p27 and low proliferation index do not correlate in hairy cell leukemia.
British J of Haematology 111:263-271, 2000.
Chiarle R., L. Budel, J. Skolnik, G. Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J. Magidson, A. Montagnoli, M. Pagano, B. Maes, C. DeWolf, and G. Ingirani.
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
Cenciarelli C., D. S. Chiaur, D. Guardavaccaro, W. Parks, M. Vidal, and Pagano M.
Current Biology 9: 1177-1179, 1999.
Carrano A. C., E. Eytan, A. Hershko, and Pagano M.
Skp2 is required for the ubiquitin-mediated degradation of the Cdk-inhibitor p27.
Nature Cell Biol 1: 193-199, 1999.
Montagnoli A., F. Fiore, E. Eytan, A. C. Carrano, G. Draetta, A. Hershko, and Pagano M.
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Genes & Development 13: 1181-1189, 1999.
Latres E., D. S. Chiaur, and Pagano M.
The human F-box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of b-catenin.
Gonen H., B. Bercovich, A. Orian, A. C. Carrano, C. Takizawa, M. Pagano, K. Iwai, and A. Ciechanover.
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkBa.
J of Biological Chemistry 274: 14823-14830, 1999.
Thomas G., K. Szigeti, M. Murphy, G. Draetta, M. Pagano, and M. Loda.
Downregulation of p27 is associated with development of colorectal adenocarcinoma metastases.
Am J Pathol 153: 681-687, 1998.
Lu Z., D. Liu, A. Hornia, W. Devonish, M. Pagano, and D. Foster.
Tumor promotion by phorbol ester-induced depletion of protein kinase C is mediated by the ubiquitin-proteasome pathway.
Mol Cell Biol 18: 839-845, 1998.
Zhang Y., Z. Wang, D. Liu, M. Pagano, and K. Ravid.
Ubiquitin-dependent degradation of Cyclin B1 is accelerated in polyploid megacariocytes.
J of Biological Chemistry 273: 1378-1392, 1998.
Singh S., J. Lipman, H. Goldman, F. H. Ellis Jr., L. Aizenman, M. G. Cangi, S. Signoretti, D. S. Chiaur, M. Pagano, and M. Loda.
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma.
Cancer Research 58: 1730-1735, 1998.
Esposito V., A. Baldi, A. DeLuca, G. Sgaramella, G. Giordano, M. Caputi, M. Pagano, and G. Gordano.
Prognostic role of the cell cycle inhibitor p27 in non-small cell lung cancer.
Cancer Research 57: 3381-3385, 1997.
Millard S., J. Yan, H. Nguyen, M. Pagano, H. Kiyokawa, and A. Koff.
Enhanced ribosomal association of p27Kip1 mRNA, a mechanism contributing to accumulation during growth arrest.
J of Biological Chemistry 272: 7093-7098, 1997.
Tan P., B. Cady, M. Wanner, B. Cukon, C. Magi-Galluzzi, P. Lavin, G. Draetta, M. Pagano, and M. Loda.
The cell cycle inhibitor p27 is an independent marker in small (T1a,b) invasive breast carcinomas.
Cancer Research 57: 1259-1263, 1997.
Loda M., B. Cukon, S. Tam, P. Lavin, M. Fiorentino, G. Draetta, J. Jessup, and Pagano M.
Increased proteasome-dependent degradation of the CDK inhibitor p27 in aggressive colorectal carcinomas.
Nature Med 3: 231-234, 1997.
Grinstein E., I. Weiert, B. Droese, M. Pagano, and H. Royer.
Cell cycle regulation of nuclear factor p92 DNA binding activity by novel phase-specific inhibitors.
J of Biological Chemistry 271: 9215-9222, 1996.
Chen J., R. Peters, P. Saha, P. Lee, A. Theodoras, M. Pagano, G. Wagner, and A. Dutta.
A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo.
Nucl Acids Res 24: 1727-1733, 1996.
Steiner P., A. Philip, J. Lukas, D. Godden, M. Pagano, S. Mittnacht, J. Bartek, and M. Eilers.
Identification of a Myc-dependent step during the assembly of active cyclin/cdk complexes.
EMBO J 14: 4814-4826, 1995.
Roussel M., A. Theodoras, M. Pagano, and C. Sherr.
Rescue of defective mitogenic signaling by D-type cyclins.
Proc Natl Acad Sci USA 92: 6837-6841, 1995.
Ohtsubo M., A. Theodoras, J. Schumacher, J. Roberts, and Pagano M.
Human Cyclin E, a nuclear protein essential for the G1 to S phase transition.
Mol Cell Biol 15: 2612-2624, 1995.
Rolfe M., P. Romero, S. Glass, I. Berdo, A. Theodoras, M. Pagano, and G. Draetta.
Reconstitution of p53-ubiquitinylation from purified components: the role of human Ubc4 and E6AP.
Proc Natl Acad Sci USA 92: 3264-3268, 1995.
Pagano M., S. Tam, A. Theodoras, P. Beer, S. Delsal, V. Chu, R. Yew, G. Draetta, and M. Rolfe.
Role of the Ubiquitin-Proteasome pathway in regulating abundance of the CDK inhibitor p27.
Tam S., J. W. Shay, and Pagano M.
Differential expression and cell cycle regulation of the Cdk4 inhibitor p16Ink4.
Cancer Research 54: 5816-5820, 1994.
Tam S., A. Theodoras, J. W. Shay, G. Draetta, and Pagano M.
Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.
Pagano M., Theodoras A. M., Tam S. W., and Draetta G.
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.
Genes & Development 8: 1627-1639, 1994.
Spitkovsky D., P. Steiner, J. Lukas, E. Lees, M. Pagano, A. Schulze, S. Joswig, M. Tommasino, M. Eilers, and P. Jansen-Dürr.
Modulation of cyclin gene expression by E1A in a cell line with E1A-dependent conditional proliferation.
J of Virology 68: 2206-2214, 1994.
Lukas J., Pagano M., Z. Staskova, G. Draetta, and J. Bartek.
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines.
Migliacio A., M. Pagano, and F. Aurichio.
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.
O'Connor P., D. Ferris, M. Pagano, G. Draetta, J. Pines, T. Hunter, D. Longo, K. Kohn.
G2 delay induced by nitrogen mustard in human cells affects Cyclin A/Cdk2 and CyclinB/Cdc2 kinase complexes differentially.
J of Biological Chemistry 268: 8298-8308, 1993.
Baldin V., J. Lukas, M. J. Marcote, M. Pagano, and G. Draetta.
Human Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
Genes & Development 7: 812-821, 1993.
J. Dürr P., A. Meichle, P. Steiner, M. Pagano, K. Finke, J. Botz, J. Wess, G. Draetta, and M. Eilers.
Differential modulation of cyclin gene expression by myc.
Proc Natl Acad Sci USA 90: 3685-3689, 1993.
Pagano M., R. Pepperkok, J. Lukas, V. Baldin, W. Ansorge, J. Bartek, and G. Draetta.
Regulation of the cell cycle by the Cdk2 protein kinase in cultured human fibroblasts.
J of Cell Biology 121: 101- 111, 1993.
Pagano M., M. Dürst, S. Joswig, G. Draetta, and P. Jansen-Dürr.
Binding of the human E2F transcription factor to the retinoblastoma protein but not Cyclin A is abolished in HPV 16-immortalized cells.
Landesman Y., M. Pagano, G. Draetta, V. Rotter, N. Fusenig, and A. Kimchi.
Modification of cell cycle controlling nuclear proteins by TGF-ß in HaCaT Keratinocyte cell-line.
Clarke P., D. Leiss, M. Pagano, and E. Karsenti.
Cyclin A and Cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extract.
EMBO J 11: 1751-1761, 1992.
Thomas L., P. R. Clarke, M. Pagano, and J. Gruenberg.
Inhibition of membrane fusion in vitro via Cyclin B but not Cyclin A.
J of Biological Chemistry 67: 6183-6187, 1992.
Pagano M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta.
Cyclin A is required at two points in the human cell cycle.
EMBO J 11: 961-972, 1992.
Pagano M., Draetta G., and Jansen-Dürr P.
Association of Cdk2 kinase with the transcription factor E2F during S phase.

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