Source: http://medline.ru/public/art/tom16/sample_art.phtml?n_art=62&n_tom=16&lng=eng
Timestamp: 2019-04-24 22:40:13+00:00

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Studied the incidence of genetic polymorphisms associated with thrombophilia in the population of Saint-Petersburg residents, Caucasian. The study included 261 healthy blood donors (150 males (57.5%) and 111 females (42.5%)). The average age of healthy donors was 35.3 ± 0.7 years (range 18 to 68 years). Distribution heterozygous mutation A506G factor V and G20210A prothrombin is found in St. Petersburg residents with a frequency of 3.8 % and 2.7 %, respectively. Performance of donor functions asymptomatic carriers of heterozygous mutations A506G factor V and G20210A prothrombin is not associated with the risk of thrombotic events. Detection of heterozygous mutations A506G factor V and G20210A prothrombin is not an absolute predictor of thrombotic events and can’t be equivalent to the concept of "hereditary thrombophilia." C677T mutation MTHFR occurs with a frequency of 42.5 % for the heterozygous form and with a frequency of 3.1 % for the homozygous form. Carriage A1298C mutation MTHFR occurs with a frequency of 36.4 % and 17.2 % for the heterozygous and homozygous form, respectively. Polymorphisms C677T and A1298C MTHFR were not predictors of thrombotic events in healthy blood donors. Not found a relationship between the frequency of detection of polymorphisms A506G factor V, G20210A prothrombin, C677T and A1298C MTHFR and blood group AB0.
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