Source: https://maps.cancer.gov/overview/DCCPSGrants/abstract.jsp?applId=9552089&term=CA182913
Timestamp: 2019-04-24 05:10:10+00:00

Document:
DESCRIPTION (provided by applicant): The WHS began in 1992 as a randomized controlled trial testing aspirin, beta-carotene, and vitamin E for preventing cancer and cardiovascular disease (CVD) in 39,876 healthy women, aged >45, The trial ended in 2004, and women have been followed observationally since that time. At study entry and annually, women report via questionnaires on a wide range of exposures and endpoints, including cancer and CVD. We confirm these self-reported endpoints with medical records, and cause of death in decedents is ascertained using medical records and death certificates. At baseline, 28,345 women also provided a blood sample, from which plasma, buffy coat, and red blood cells were obtained and stored at -170 ?C. GWAS data on common variation are available for all women with blood, measurement of rare variants in exomes have just been completed for >23,000 women; and all samples have been assayed for several biomarkers. Objectively assessed 7-day physical activity by accelerometer is being collected on ~18,000 women. The WHS cohort is unique in having GWAS and objectively-assessed physical activity in such a large cohort. Follow-up is excellent; after almost 20 years, morbidity follow-up is 94 percent; and mortality follow-up is virtually 100 percent. At the end of current funding, 6,086 confirmed cancers (2,440 breast, 583 colorectal, 537 lung, 1,517 cancer deaths) will have occurred. During the proposed funding period, cancer and CVD endpoints will increase by 30 percent and 51 percent. The WHS has actively provided data to internal and external researchers, with 444 papers published, 89 ancillary studies funded, and participation in 19 NCI Cohort Consortium collaborative projects. In the proposed funding period, we intend to: (1) continue to update exposure and endpoint information, and maintain the repository of biospecimens, to further facilitate data sharing and collaboration, and (2) use the WHS infrastructure to address specific aims related to physical activity; evaluate the translational potential of gene-based risk and explore gene-by-environment interactions; and examine long-term chemo-protection of low-dose aspirin on cancer. None of the ancillary studies provides funding for ascertainment and validation of cancer (and CVD) endpoints. Continued infrastructure support and follow-up is crucial for maximizing the cost-effective use of this valuable large-scale cohort of women with a rich bank of already collected phenotypic and genetic data. RELEVANCE: This application seeks support over the next 5 years for the infrastructure of the Women's Health Study, a large-scale cancer epidemiology cohort of 39,876 women followed since 1992, Data are available on a wide range of characteristics, chronic disease development, blood biomarkers, genetic information, and objectively measured physical activity. Continued follow-up is crucial for building on the enormous amount of data already collected in order to answer critical questions related to cancer.
Authors: Pasquale L.R. , Aschard H. , Kang J.H. , Bailey J.N. , Lindström S. , Chasman D.I. , Christen W.G. , Allingham R.R. , Ashley-Koch A. , Lee R.K. , et al. .
Source: Menopause (new York, N.y.), 2017 Feb; 24(2), p. 150-156.
Strength Training and the Risk of Type 2 Diabetes and Cardiovascular Disease.
Authors: Shiroma E.J. , Cook N.R. , Manson J.E. , Moorthy M.V. , Buring J.E. , Rimm E.B. , Lee I.M. .
Source: Medicine And Science In Sports And Exercise, 2017 Jan; 49(1), p. 40-46.
Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study.
Authors: Patel R.B. , Moorthy M.V. , Chiuve S.E. , Pradhan A.D. , Cook N.R. , Albert C.M. .
Source: Heart Rhythm, 2017 Jan; 14(1), p. 72-78.
Authors: Rhee J.J. , Kim E. , Buring J.E. , Kurth T. .
Source: American Journal Of Preventive Medicine, 2017 Jan; 52(1), p. 10-19.
Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms.
Authors: Babic A. , Bao Y. , Qian Z.R. , Yuan C. , Giovannucci E.L. , Aschard H. , Kraft P. , Amundadottir L.T. , Stolzenberg-Solomon R. , Morales-Oyarvide V. , et al. .
Source: Cancer Research, 2016-12-15 00:00:00.0; 76(24), p. 7160-7167.
Authors: Campbell P.T. , Newton C.C. , Freedman N.D. , Koshiol J. , Alavanja M.C. , Beane Freeman L.E. , Buring J.E. , Chan A.T. , Chong D.Q. , Datta M. , et al. .
Source: Cancer Research, 2016-10-15 00:00:00.0; 76(20), p. 6076-6083.
Authors: Zhang M. , Wang Z. , Obazee O. , Jia J. , Childs E.J. , Hoskins J. , Figlioli G. , Mocci E. , Collins I. , Chung C.C. , et al. .
Source: Oncotarget, 2016-10-11 00:00:00.0; 7(41), p. 66328-66343.
Authors: Liu C. , Kraja A.T. , Smith J.A. , Brody J.A. , Franceschini N. , Bis J.C. , Rice K. , Morrison A.C. , Lu Y. , Weiss S. , et al. .
Source: Nature Genetics, 2016 Oct; 48(10), p. 1162-70.
Authors: Ehret G.B. , Ferreira T. , Chasman D.I. , Jackson A.U. , Schmidt E.M. , Johnson T. , Thorleifsson G. , Luan J. , Donnelly L.A. , Kanoni S. , et al. .
Source: Nature Genetics, 2016 Oct; 48(10), p. 1171-84.
Authors: Winter A.C. , Rist P.M. , Buring J.E. , Kurth T. .
Source: Bmj Open, 2016-09-26 00:00:00.0; 6(9), p. e011888.
Association Between Markers of Inflammation and Total Stroke by Hypertensive Status Among Women.
Authors: Jiménez M.C. , Rexrode K.M. , Kotler G. , Everett B.M. , Glynn R.J. , Lee I.M. , Buring J.E. , Ridker P.M. , Sesso H.D. .
Source: American Journal Of Hypertension, 2016 Sep; 29(9), p. 1117-24.
Authors: Wentzensen N. , Poole E.M. , Trabert B. , White E. , Arslan A.A. , Patel A.V. , Setiawan V.W. , Visvanathan K. , Weiderpass E. , Adami H.O. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-08-20 00:00:00.0; 34(24), p. 2888-98.
Authors: Yuan C. , Qian Z.R. , Babic A. , Morales-Oyarvide V. , Rubinson D.A. , Kraft P. , Ng K. , Bao Y. , Giovannucci E.L. , Ogino S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-08-20 00:00:00.0; 34(24), p. 2899-905.
Authors: Joshi A.D. , Andersson C. , Buch S. , Stender S. , Noordam R. , Weng L.C. , Weeke P.E. , Auer P.L. , Boehm B. , Chen C. , et al. .
Source: Gastroenterology, 2016 Aug; 151(2), p. 351-363.e28.
Authors: Gormley P. , Anttila V. , Winsvold B.S. , Palta P. , Esko T. , Pers T.H. , Farh K.H. , Cuenca-Leon E. , Muona M. , Furlotte N.A. , et al. .
Source: Nature Genetics, 2016 Aug; 48(8), p. 856-66.
Multivitamin use and the risk of hypertension in a prospective cohort study of women.
Authors: Rautiainen S. , Wang L. , Lee I.M. , Manson J.E. , Gaziano J.M. , Buring J.E. , Sesso H.D. .
Source: Journal Of Hypertension, 2016 Aug; 34(8), p. 1513-9.
Catechol-O-methyltransferase association with hemoglobin A1c.
Authors: Hall K.T. , Jablonski K.A. , Chen L. , Harden M. , Tolkin B.R. , Kaptchuk T.J. , Bray G.A. , Ridker P.M. , Florez J.C. , Diabetes Prevention Program Research Group , et al. .
Source: Metabolism: Clinical And Experimental, 2016 Jul; 65(7), p. 961-7.
Endophenotype Network Models: Common Core of Complex Diseases.
Authors: Ghiassian S.D. , Menche J. , Chasman D.I. , Giulianini F. , Wang R. , Ricchiuto P. , Aikawa M. , Iwata H. , Müller C. , Zeller T. , et al. .
Source: Scientific Reports, 2016-06-09 00:00:00.0; 6, p. 27414.
Physical and neurobehavioral determinants of reproductive onset and success.
Authors: Day F.R. , Helgason H. , Chasman D.I. , Rose L.M. , Loh P.R. , Scott R.A. , Helgason A. , Kong A. , Masson G. , Magnusson O.T. , et al. .
Source: Nature Genetics, 2016 Jun; 48(6), p. 617-23.
Lipid biomarkers and long-term risk of cancer in the Women's Health Study.
Authors: Chandler P.D. , Song Y. , Lin J. , Zhang S. , Sesso H.D. , Mora S. , Giovannucci E.L. , Rexrode K.E. , Moorthy M.V. , Li C. , et al. .
Source: The American Journal Of Clinical Nutrition, 2016 Jun; 103(6), p. 1397-407.
Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.
Authors: Eising E. , Huisman S.M. , Mahfouz A. , Vijfhuizen L.S. , Anttila V. , Winsvold B.S. , Kurth T. , Ikram M.A. , Freilinger T. , Kaprio J. , et al. .
Source: Human Genetics, 2016 Apr; 135(4), p. 425-39.
Dairy consumption in association with weight change and risk of becoming overweight or obese in middle-aged and older women: a prospective cohort study.
Authors: Rautiainen S. , Wang L. , Lee I.M. , Manson J.E. , Buring J.E. , Sesso H.D. .
Source: The American Journal Of Clinical Nutrition, 2016 Apr; 103(4), p. 979-88.
Authors: Lawler P.R. , Akinkuolie A.O. , Chandler P.D. , Moorthy M.V. , Vandenburgh M.J. , Schaumberg D.A. , Lee I.M. , Glynn R.J. , Ridker P.M. , Buring J.E. , et al. .
Source: Circulation Research, 2016-04-01 00:00:00.0; 118(7), p. 1106-15.
Authors: Rist P.M. , Buring J.E. , Kase C.S. , Kurth T. .
Source: The American Journal Of Medicine, 2016-02-17 00:00:00.0; , .
Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.
Authors: Kitahara C.M. , McCullough M.L. , Franceschi S. , Rinaldi S. , Wolk A. , Neta G. , Olov Adami H. , Anderson K. , Andreotti G. , Beane Freeman L.E. , et al. .
Source: Thyroid : Official Journal Of The American Thyroid Association, 2016 Feb; 26(2), p. 306-18.
Authors: Ma Y. , Follis J.L. , Smith C.E. , Tanaka T. , Manichaikul A.W. , Chu A.Y. , Samieri C. , Zhou X. , Guan W. , Wang L. , et al. .
Source: The American Journal Of Clinical Nutrition, 2016 Feb; 103(2), p. 567-78.
Comparison of physical activity assessed using hip- and wrist-worn accelerometers.
Authors: Kamada M. , Shiroma E.J. , Harris T.B. , Lee I.M. .
Source: Gait & Posture, 2016 Feb; 44, p. 23-8.
Authors: Pattaro C. , Teumer A. , Gorski M. , Chu A.Y. , Li M. , Mijatovic V. , Garnaas M. , Tin A. , Sorice R. , Li Y. , et al. .
Source: Nature Communications, 2016-01-21 00:00:00.0; 7, p. 10023.
Authors: Kilpeläinen T.O. , Carli J.F. , Skowronski A.A. , Sun Q. , Kriebel J. , Feitosa M.F. , Hedman Å.K. , Drong A.W. , Hayes J.E. , Zhao J. , et al. .
Source: Nature Communications, 2016; 7, p. 10494.
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.
Authors: Norby F.L. , Eryd S.A. , Niemeijer M.N. , Rose L.M. , Smith A.V. , Yin X. , Agarwal S.K. , Arking D.E. , Chasman D.L. , Chen L.Y. , et al. .
Source: Plos One, 2016; 11(3), p. e0151932.
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.
Authors: Sung Y.J. , Winkler T.W. , Manning A.K. , Aschard H. , Gudnason V. , Harris T.B. , Smith A.V. , Boerwinkle E. , Brown M.R. , Morrison A.C. , et al. .
Source: Genetic Epidemiology, 2016 07; 40(5), p. 404-15.
Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons.
Authors: Samieri C. , Morris M.C. , Bennett D.A. , Berr C. , Amouyel P. , Dartigues J.F. , Tzourio C. , Chasman D.I. , Grodstein F. .
Source: American Journal Of Epidemiology, 2018-05-01 00:00:00.0; 187(5), p. 933-940.
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Authors: Emdin C.A. , Khera A.V. , Chaffin M. , Klarin D. , Natarajan P. , Aragam K. , Haas M. , Bick A. , Zekavat S.M. , Nomura A. , et al. .
Source: Nature Communications, 2018-04-24 00:00:00.0; 9(1), p. 1613.
Markers of Inflammation and Incident Breast Cancer Risk in the Women's Health Study.
Authors: Tobias D.K. , Akinkuolie A.O. , Chandler P.D. , Lawler P.R. , Manson J.E. , Buring J.E. , Ridker P.M. , Wang L. , Lee I.M. , Mora S. .
Source: American Journal Of Epidemiology, 2018-04-01 00:00:00.0; 187(4), p. 705-716.
Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women.
Authors: Tobias D.K. , Lawler P.R. , Harada P.H. , Demler O.V. , Ridker P.M. , Manson J.E. , Cheng S. , Mora S. .
Source: Circulation. Genomic And Precision Medicine, 2018 Apr; 11(4), p. e002157.
Migraine and invasive epithelial ovarian cancer risk in the Nurses' Health Study II and the Women's Health Study.
Authors: Rice M.S. , Rist P.M. , Winter A.C. , Kurth T. , Tworoger S.S. .
Source: International Journal Of Cancer, 2018-02-01 00:00:00.0; 142(3), p. 534-539.
Authors: Chandler P.D. , Tobias D.K. , Wang L. , Smith-Warner S.A. , Chasman D.I. , Rose L. , Giovannucci E.L. , Buring J.E. , Ridker P.M. , Cook N.R. , et al. .
Source: Nutrients, 2018-01-09 00:00:00.0; 10(1), .
Adiposity and Genetic Factors in Relation to Triglycerides and Triglyceride-Rich Lipoproteins in the Women's Genome Health Study.
Authors: Ahmad S. , Mora S. , Franks P.W. , Orho-Melander M. , Ridker P.M. , Hu F.B. , Chasman D.I. .
Source: Clinical Chemistry, 2018 Jan; 64(1), p. 231-241.
Authors: Rist P.M. , Winter A.C. , Buring J.E. , Sesso H.D. , Kurth T. .
Source: Cephalalgia : An International Journal Of Headache, 2018-01-01 00:00:00.0; , p. 333102418756865.
Accelerometer-Measured Physical Activity and Sedentary Behavior in Relation to All-Cause Mortality: The Women's Health Study.
Authors: Lee I.M. , Shiroma E.J. , Evenson K.R. , Kamada M. , LaCroix A.Z. , Buring J.E. .
Source: Circulation, 2017-11-06 00:00:00.0; , .
Authors: Sapkota Y. , Vivo I. , Steinthorsdottir V. , Fassbender A. , Bowdler L. , Buring J.E. , Edwards T.L. , Jones S. , O D. , Peterse D. , et al. .
Source: Scientific Reports, 2017-09-12 00:00:00.0; 7(1), p. 11380.
Authors: Harada P.H.N. , Demler O.V. , Dugani S.B. , Akinkuolie A.O. , Moorthy M.V. , Ridker P.M. , Cook N.R. , Pradhan A.D. , Mora S. .
Source: Journal Of Clinical Lipidology, 2017 Sep - Oct; 11(5), p. 1257-1267.e2.
Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study.
Authors: van Capelleveen J.C. , Bochem A.E. , Boekholdt S.M. , Mora S. , Hoogeveen R.C. , Ballantyne C.M. , Ridker P.M. , Sun W. , Barter P.J. , Tall A.R. , et al. .
Source: Journal Of The American Heart Association, 2017-08-03 00:00:00.0; 6(8), .
Authors: Wain L.V. , Vaez A. , Jansen R. , Joehanes R. , van der Most P.J. , Erzurumluoglu A.M. , O'Reilly P.F. , Cabrera C.P. , Warren H.R. , Rose L.M. , et al. .
Source: Hypertension (dallas, Tex. : 1979), 2017-07-24 00:00:00.0; , .
Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.
Authors: Lindström S. , Germain M. , Crous-Bou M. , Smith E.N. , Morange P.E. , van Hylckama Vlieg A. , de Haan H.G. , Chasman D. , Ridker P. , Brody J. , et al. .
Source: Human Genetics, 2017 Jul; 136(7), p. 897-902.
Authors: Day F.R. , Thompson D.J. , Helgason H. , Chasman D.I. , Finucane H. , Sulem P. , Ruth K.S. , Whalen S. , Sarkar A.K. , Albrecht E. , et al. .
Source: Nature Genetics, 2017 Jun; 49(6), p. 834-841.
Authors: Justice A.E. , Winkler T.W. , Feitosa M.F. , Graff M. , Fisher V.A. , Young K. , Barata L. , Deng X. , Czajkowski J. , Hadley D. , et al. .
Source: Nature Communications, 2017-04-26 00:00:00.0; 8, p. 14977.
Authors: Ose J. , Poole E.M. , Schock H. , Lehtinen M. , Arslan A.A. , Zeleniuch-Jacquotte A. , Visvanathan K. , Helzlsouer K.J. , Buring J.E. , Lee I.M. , et al. .
Source: Cancer Research, 2017-04-05 00:00:00.0; , .
Authors: Chatterjee N.A. , Giulianini F. , Geelhoed B. , Lunetta K.L. , Misialek J.R. , Niemeijer M.N. , Rienstra M. , Rose L.M. , Smith A.V. , Arking D.E. , et al. .
Source: Circulation, 2017-02-21 00:00:00.0; 135(8), p. 741-754.

References: V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V.