Source: https://people.epfl.ch/michel.aguet
Timestamp: 2019-04-23 04:29:41+00:00

Document:
Dr. Michel Aguet, MD, held positions in academia and industry (Associate Professor at the Institute of Molecular Biology, University of Zürich; Head of Molecular Oncology, Genentech, So. San Francisco) before he was appointed director of the Swiss Institute for Experimental Cancer Research (ISREC) (1996-2009). In the context of the integration of ISREC into the Swiss Federal Institute of Technology (EPFL), he was appointed as Full Professor at the newly established School of Life Sciences in 2005. From 2001-2013 he directed the National Center of Competence in Research (NCCR) in Molecular Oncology, a national program launched by the Swiss National Science Foundation to encourage translational cancer research and for which ISREC was the leading house. Dr. Aguet has been a SAB member in the pharmaceutical industry, biotech industry and venture capital industry since 1997.
A large part of his scientific career was devoted to exploring the molecular biology of interferons (cloning of the interferon gamma receptor, generation of various interferon signaling mutants in the mouse) and, in collaboration with Prof. Charles Weissmann, to investigating the role of prion related protein PrP in mouse prion disease models. In recent years his research focused on characterizing the role of BCL9 proteins, which are part of the Wnt/beta-catenin transcriptional activation complex, in regulating stem cell traits in intestinal epithelium and colorectal cancer. His laboratory is now closed due to retirement.
C. Cantu; A. Felker; D. Zimmerli; K. D. Prummel; E. M. Cabello et al. : Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling; Genes & Development. 2018-11-01. DOI : 10.1101/gad.315531.118.
E. Gjoni; C. Aguet; D. A. Sahlender; G. Knott; R. Schneggenburger : Ultrastructural basis of strong unitary inhibition in a binaural neuron; Journal Of Physiology-London. 2018-10-15. DOI : 10.1113/JP276015.
G. Aguettant : Washboard effect of unpaved roads ; 2018-07-27.
M. Murone; R. Radpour; A. Attinger; A. V. Chessex; A.-L. Huguenin et al. : The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells; Molecular Cancer Therapeutics. 2017. DOI : 10.1158/1535-7163.Mct-16-0889.
M. Murone; A. V. Chessex; A. Attinger; R. Ramachandra; S. J. Shetty et al. : Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases; Molecular Cancer Therapeutics. 2016. DOI : 10.1158/1535-7163.Mct-15-0974.
T. Valenta; B. Degirmenci; A. E. Moor; P. Herr; D. Zimmerli et al. : Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis; Cell Reports. 2016. DOI : 10.1016/j.celrep.2016.03.088.
L. Cironi; T. Petricevic; V. F. Vieira; P. Provero; C. Fusco et al. : The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma; Scientific Reports. 2016. DOI : 10.1038/srep22113.
A. E. Moor; P. Anderle; C. Cantu; P. Rodriguez; N. Wiedemann et al. : CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer; Ebiomedicine. 2015. DOI : 10.1016/j.ebiom.2015.10.030.
A. E. Moor / M. Aguet (Dir.) : The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6449.
C. Cantù; D. Zimmerli; G. Hausmann; T. Valenta; A. Moor et al. : Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development; Genes & Development. 2014. DOI : 10.1101/gad.246140.114.
C. Cantu; T. Valenta; G. Hausmann; N. Vilain; M. Aguet et al. : The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription; Development. 2013. DOI : 10.1242/dev.093591.
H. Kirshner; F. Aguet; D. Sage; M. Unser : 3-D PSF fitting for fluorescence microscopy: implementation and localization application; Journal Of Microscopy. 2013. DOI : 10.1111/j.1365-2818.2012.03675.x.
J. Christensen; S. El-Gebali; M. Natoli; T. Sengstag; M. Delorenzi et al. : Defining new criteria for selection of cell-based intestinal models using publicly available databases; Bmc Genomics. 2012. DOI : 10.1186/1471-2164-13-274.
E. Susanto / J. Huelsken (Dir.) : Identification of a Novel Wnt Inhibitor. Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.
H. Fournier : Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model ; 2011.
N. Mackinnon : The Creation of EBV Biotech ; 2011.
N. Wiedemann / M. Aguet (Dir.) : Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium. Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5207.
G. González Serrano; F. Fleuret; F. Aguet; F. Benmansour; M. Unser et al. : Rotational Features Extraction for Ridge Detection. 2011.
A. Bourquard; F. Aguet; M. Unser : Optical Imaging Using Binary Sensors; Optics Express. 2010. DOI : 10.1364/OE.18.004876.
E. Pasquier : Pre-clinical characterization of long synthetic peptide vaccine candidates against melanoma ; 2010.
F. Bringolf : Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines ; 2010.
J. Deka; N. Wiedemann; P. Anderle Pedone; F. Murphy-Seiler; J. Bultinck et al. : Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas; Cancer Research. 2010. DOI : 10.1158/0008-5472.CAN-10-0148.
G. González; F. Aguet; F. Fleuret; M. Unser; P. Fua : Steerable Features for Statistical 3D Dendrite Detection; Proceedings of the Twelfth International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI'09). 2009. DOI : 10.1007/978-3-642-04271-3_76.
F. Aguet; S. Geissbühler; I. Märki; T. Lasser; M. Unser : Steerable Filters for Orientation Estimation and Localization of Fluorescent Dipoles. 2009. p. 1166–1169. DOI : 10.1109/ISBI.2009.5193265.
A. S. Brack; F. Murphy-Seiler; J. Hanifi; J. Deka; S. Eyckerman et al. : BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration; Developmental biology. 2009. DOI : 10.1016/j.ydbio.2009.08.014.
P. Farmer; H. Bonnefoi; P. Anderle; D. Cameron; P. Wirapati et al. : A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer; Nature medicine. 2009. DOI : 10.1038/nm.1908.
G. Gonzalez; F. Aguet; F. Fleuret; M. Unser; P. Fua : Steerable Features for Statistical 3D Dendrite Detection. 2009. International Conference on Medical Image Computing and Computer Assisted Intervention. p. 625-632.
S. Geissbühler; F. Aguet; I. Märki; T. Lasser; M. Unser : Super-resolved position and orientation from defocused images of fluorescent dipoles ; European Conference on Biomedical Optics, Munich, June 14–18 2009.
F. Aguet; S. Geissbühler; I. Märki; T. Lasser; M. Unser : Steerable filters for orientation estimation and localization of fluorescent dipoles. 2009. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Boston, Massachusetts, June 28 - July 1, 2009. p. 1166-1169. DOI : 10.1109/ISBI.2009.5193265.
S. Geissbühler; F. Aguet; I. Märki; T. Lasser; M. Unser : High-resolution imaging with simultaneous estimation of position and orientation of single molecules ; Biomedical Photonics Network day 2009 (BMPN), Fisba Optik AG, St. Gallen, Switzerland, June 10 2009.
F. Aguet; S. Geissbühler; I. Märki; T. Lasser; M. Unser : Super-resolved position and orientation of fluorescent dipoles. 2009. ECBO 2009, Advanced Microscopy Techniques, Munich, Germany, June 14-18 2009. p. 73670Y. DOI : 10.1117/12.831488.
F. Aguet; S. Geissbühler; I. Märki; T. Lasser; M. Unser : Super-resolution orientation estimation and localization of fluorescent dipoles using 3-D steerable filters; Optics Express. 2009. DOI : 10.1364/OE.17.006829.
F. Aguet / M. Unser (Dir.) : Super-resolution fluorescence microscopy based on physical models. Lausanne, EPFL, 2009. DOI : 10.5075/epfl-thesis-4418.
C. Seelamantula; F. Aguet; S. Romain; P. Thévenaz; M. Unser : Parametric B-Spline Snakes on Distance Maps—Application to Segmentation of Histology Images; Proceedings of the Sixteenth European Signal Processing Conference (EUSIPCO'08). 2008.
F. Aguet; D. Van De Ville; M. Unser : An Accurate PSF Model with Few Parameters for Axially Shift-Variant Deconvolution. 2008. p. 157–160.
F. Aguet; D. Van De Ville; M. Unser : An accurate PSF model with few parameters for axially shift-variant deconvolution. 2008. 5th IEEE International Symposium on Biomedical Imaging - From Nano to Macro, Paris, FRANCE, May 14-17, 2008. p. 157-160.
C. Gubelmann : Gene expression analysis of metastases and tumor host interactions in metastatic lesions in a multistage model of prostate carcinogenesis ; 2008.
A. Planche : Gene expression profiling of the stromal reaction to invasive human breast and prostate cancer ; 2008.
F. Aguet; D. Van De Ville; M. Unser : Model-Based 2.5-D Deconvolution for Extended Depth of Field in Brightfield Microscopy; IEEE Transactions on Image Processing. 2008. DOI : 10.1109/TIP.2008.924393.
F. Aguet; D. Van De Ville; M. Unser : Sub-Resolution Maximum-Likelihood Based Localization of Fluorescent Nanoparticles in Three Dimensions. 2007. p. 932–935.
F. Aguet; D. Van De Ville; M. Unser : Sub-resolution maximum-likelihood based localization of fluorescent nanoparticles in three dimensions. 2007. 4th IEEE International Symposium on Biomedical Imaging - Macro to Nano, Arlington, VA, Apr 12-15, 2007. p. 932-935.
R. L. van Bezooijen; M. C. Deruiter; N. Vilain; R. M. Monteiro; A. Visser et al. : SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development; Developmental dynamics : an official publication of the American Association of Anatomists. 2007. DOI : 10.1002/dvdy.21054.
A. Wilson; D. L. Ardiet; C. Saner; N. Vilain; F. Beermann et al. : Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike; Journal of Immunology. 2007.
F. Aguet; D. Van De Ville; M. Unser : Joint Texture and Topography Estimation for Extended Depth of Field in Brightfield Microscopy; Proceedings of the Third IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'06). 2006. DOI : 10.1109/ISBI.2006.1625032.
C. Vonesch; F. Aguet; J.-L. Vonesch; M. Unser : The Colored Revolution of Bioimaging; IEEE Signal Processing Magazine. 2006. DOI : 10.1109/MSP.2006.1628875.
X. D. Wang; C. C. Leow; J. Zha; Z. Tang; Z. Modrusan et al. : Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation; Dev Biol. 2006. DOI : 10.1016/j.ydbio.2005.11.009.
F. Aguet; D. Van De Ville; M. Unser : Sub-Resolution Axial Localization of Nanoparticles in Fluorescence Microscopy; Proceedings of the SPIE European Conference on Biomedical Optics: Confocal, Multiphoton, and Nonlinear Microscopic Imaging II (ECBO'05). 2005.
F. Aguet; M. Jacob; M. Unser : Three-Dimensional Feature Detection Using Optimal Steerable Filters. 2005. p. 1158–1161. DOI : 10.1109/ICIP.2005.1530266.
F. Aguet; D. Van De Ville; M. Unser : A Maximum-Likelihood Formalism for Sub-Resolution Axial Localization of Fluorescent Nanoparticles; Optics Express. 2005. DOI : 10.1364/OPEX.13.010503.
S. Lutolf; F. Radtke; M. Aguet; U. Suter; V. Taylor : Notch1 is required for neuronal and glial differentiation in the cerebellum; Development. 2002.
S. Genoud; C. Lappe-Siefke; S. Goebbels; F. Radtke; M. Aguet et al. : Notch1 control of oligodendrocyte differentiation in the spinal cord; J Cell Biol. 2002. DOI : 10.1083/jcb.200202002.
O. Zilian; C. Saner; L. Hagedorn; H. Y. Lee; E. Sauberli et al. : Multiple roles of mouse Numb in tuning developmental cell fates; Curr Biol. 2001. DOI : 10.1016/S0960-9822(01)00149-X.
A. Rangarajan; C. Talora; R. Okuyama; M. Nicolas; C. Mammucari et al. : Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation; Embo J. 2001. DOI : 10.1093/emboj/20.13.3427.
M. Jenni; K. Basler; E. Hafen; M. Aguet : The Genetics Company, Inc. - A newly founded Swiss Biotech Company; Chimia. 2000.
F. Radtke; I. Ferrero; A. Wilson; R. Lees; M. Aguet et al. : Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells; J Exp Med. 2000. DOI : 10.1084/jem.191.7.1085.
F. Radtke; A. Wilson; G. Stark; M. Bauer; J. van Meerwijk et al. : Deficient T cell fate specification in mice with an induced inactivation of Notch1; Immunity. 1999. DOI : 10.1016/S1074-7613(00)80054-0.
H. P. Gerber; K. J. Hillan; A. M. Ryan; J. Kowalski; G. A. Keller et al. : VEGF is required for growth and survival in neonatal mice; Development. 1999.
D. Tabara / M. Ianoz (Dir.) : Effets électromagnétiques de manoeuvres et de la foudre dans les postes sous enveloppe métallique. Lausanne, EPFL, 1999. DOI : 10.5075/epfl-thesis-1970.
S. D. Spencer; F. Di Marco; J. Hooley; S. Pitts-Meek; M. Bauer et al. : The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor; Journal of Experimental Medicine. 1998. DOI : 10.1084/jem.187.4.571.
D. H. Kaplan; V. Shankaran; A. S. Dighe; E. Stockert; M. Aguet et al. : Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice; Proc Natl Acad Sci U S A. 1998. DOI : 10.1073/pnas.95.13.7556.
B. Wang; I. Andre; A. Gonzalez; J. D. Katz; M. Aguet et al. : Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes; Proceedings of the National Academy of Sciences of the United States of America. 1997. DOI : 10.1073/pnas.94.25.13844.
G. Merlin; B. J. van der Leede; K. McKune; N. Knezevic; W. Bannwarth et al. : The gene for the ligand binding chain of the human interferon gamma receptor; Immunogenetics. 1997. DOI : 10.1007/s002510050223.
M. F. Bachmann; U. Kalinke; A. Althage; G. Freer; C. Burkhart et al. : The role of antibody concentration and avidity in antiviral protection; Science. 1997. DOI : 10.1126/science.276.5321.2024.
E. A. Bach; M. Aguet; R. D. Schreiber : The IFN gamma receptor: A paradigm for cytokine receptor signaling; Annual Review of Immunology. 1997. DOI : 10.1146/annurev.immunol.15.1.563.
M. A. Meraz; J. M. White; K. C. Sheehan; E. A. Bach; S. J. Rodig et al. : Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway; Cell. 1996. DOI : 10.1016/S0092-8674(00)81288-X.
V. C. Gibbs; M. Takahashi; M. Aguet; A. Chuntharapai : A negative regulatory region in the intracellular domain of the human interferon-alpha receptor; Journal of Biological Chemistry. 1996. DOI : 10.1074/jbc.271.45.28710.
H. P. Eugster; M. Muller; U. Karrer; B. D. Car; B. Schnyder et al. : Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice; Int Immunol. 1996. DOI : 10.1093/intimm/8.1.23.
A. J. Coyle; S. Tsuyuki; C. Bertrand; S. Huang; M. Aguet et al. : Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile; J Immunol. 1996.
E. A. Bach; J. W. Tanner; S. Marsters; A. Ashkenazi; M. Aguet et al. : Ligand-induced assembly and activation of the gamma interferon receptor in intact cells; Molecular and Cellular Biology. 1996.
Y. L. Yang; L. F. Reis; J. Pavlovic; A. Aguzzi; R. Schafer et al. : Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase; Embo J. 1995.
G. Williams; N. Ruegg; A. Birch; C. Weber; K. Hofstadter et al. : Dissection of the extracellular human interferon gamma receptor alpha-chain into two immunoglobulin-like domains. Production in an Escherichia coli thioredoxin gene fusion expression system and recognition by neutralizing antibodies; Biochemistry. 1995. DOI : 10.1021/bi00005a036.
M. F. Vandenbroek; U. Muller; S. Huang; M. Aguet; R. M. Zinkernagel : Antiviral Defense in Mice Lacking Both Alpha/Beta and Gamma-Interferon Receptors; Journal of Virology. 1995.
M. F. van den Broek; U. Muller; S. Huang; R. M. Zinkernagel; M. Aguet : Immune defence in mice lacking type I and/or type II interferon receptors; Immunol Rev. 1995. DOI : 10.1111/j.1600-065X.1995.tb00090.x.
M. F. van den Broek; U. Muller; S. Huang; M. Aguet; R. M. Zinkernagel : Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors; J Virol. 1995.
M. Tsuji; Y. Miyahira; R. S. Nussenzweig; M. Aguet; M. Reichel et al. : Development of Antimalaria Immunity in Mice Lacking Ifn-Gamma Receptor; Journal of Immunology. 1995.
K. Swihart; U. Fruth; N. Messmer; K. Hug; R. Behin et al. : Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response; J Exp Med. 1995. DOI : 10.1084/jem.181.3.961.
U. Steinhoff; U. Muller; A. Schertler; H. Hengartner; M. Aguet et al. : Antiviral Protection by Vesicular Stomatitis Virus-Specific Antibodies in Alpha/Beta Interferon Receptor-Deficient Mice; Journal of Virology. 1995.
M. Saulnier; S. Huang; M. Aguet; B. Ryffel : Role of Interferon-Gamma in Contact Hypersensitivity Assessed in Interferon-Gamma Receptor-Deficient Mice; Toxicology. 1995. DOI : 10.1016/0300-483X(95)03101-K.
J. Ruby; H. Bluethmann; M. Aguet; I. A. Ramshaw : Cd40 Ligand Has Potent Antiviral Activity; Nature Medicine. 1995. DOI : 10.1038/nm0595-437.
V. Rousseau; I. Cremer; E. Lauret; I. Riviere; M. Aguet et al. : Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor; J Interferon Cytokine Res. 1995.
J. P. Rosat; F. Conceicao-Silva; G. A. Waanders; F. Beermann; A. Wilson et al. : Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells; Infect Immun. 1995.
L. Ozmen; M. Aguet; G. Trinchieri; G. Garotta : The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon; J Virol. 1995.
P. Matthys; G. Froyen; L. Verdot; S. Huang; H. Sobis et al. : IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide; J Immunol. 1995.
R. Kuhn; F. Schwenk; M. Aguet; K. Rajewsky : Inducible gene targeting in mice; Science. 1995.
R. Kamijo; J. Gerecitano; D. Shapiro; S. J. Green; M. Aguet et al. : Generation of nitric oxide and clearance of interferon-gamma after BCG infection are impaired in mice that lack the interferon-gamma receptor; J Inflamm. 1995.
C. Haas; B. Ryffel; M. Aguet; M. Le Hir : MHC antigens in interferon gamma (IFN gamma) receptor deficient mice: IFN gamma-dependent up-regulation of MHC class II in renal tubules; Kidney Int. 1995. DOI : 10.1038/ki.1995.470.
I. E. Flesch; J. H. Hess; S. Huang; M. Aguet; J. Rothe et al. : Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha; J Exp Med. 1995. DOI : 10.1084/jem.181.5.1615.
L. Fiette; C. Aubert; U. Muller; S. Huang; M. Aguet et al. : Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors; J Exp Med. 1995. DOI : 10.1084/jem.181.6.2069.
V. M. Eng; B. D. Car; B. Schnyder; M. Lorenz; S. Lugli et al. : The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo; J Exp Med. 1995. DOI : 10.1084/jem.181.5.1893.
A. Cauwels; P. Brouckaert; J. Grooten; S. Huang; M. Aguet et al. : Involvement of Ifn-Gamma in Bacillus Calmette-Guerin-Induced but Not in Tumor-Induced Sensitization to Tnf-Induced Lethality; Journal of Immunology. 1995.
O. Cases; I. Seif; J. Grimsby; P. Gaspar; K. Chen et al. : Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA; Science. 1995.
B. D. Car; V. M. Eng; B. Schnyder; M. Lehir; A. N. Shakhov et al. : Role of Interferon-Gamma in Interleukin 12-Induced Pathology in Mice; American Journal of Pathology. 1995.
A. Bridges; A. Birch; G. Williams; M. Aguet; D. Schlatter et al. : Variable region cDNA sequences and characterization of murine anti-human interferon gamma receptor monoclonal antibodies that inhibit receptor binding by interferon gamma; Molecular Immunology. 1995. DOI : 10.1016/0161-5890(95)00114-X.
E. A. Bach; S. J. Szabo; A. S. Dighe; A. Ashkenazi; M. Aguet et al. : Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets; Science. 1995.
C. Weissmann; H. Bueler; M. Fischer; A. Sauer; M. Aguet : Susceptibility to Scrapie in Mice Is Dependent on Prpc; Philosophical Transactions of the Royal Society of London Series B-Biological Sciences. 1994. DOI : 10.1098/rstb.1994.0040.
C. Weissmann; H. Bueler; M. Fischer; A. Sailer; A. Aguzzi et al. : PrP-deficient mice are resistant to scrapie; Ann N Y Acad Sci. 1994. DOI : 10.1111/j.1749-6632.1994.tb38913.x.
V. E. Schijns; B. L. Haagmans; E. O. Rijke; S. Huang; M. Aguet et al. : IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses; J Immunol. 1994.
L. F. Reis; H. Ruffner; G. Stark; M. Aguet; C. Weissmann : Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes; Embo J. 1994.
U. Muller; U. Steinhoff; L. F. Reis; S. Hemmi; J. Pavlovic et al. : Functional role of type I and type II interferons in antiviral defense; Science. 1994.
S. Hemmi; R. Bohni; G. Stark; F. Di Marco; M. Aguet : A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells; Cell. 1994. DOI : 10.1016/0092-8674(94)90355-7.

References: V. 
 V. 
 V. 
 V. 
 V. 

V. 

V. 

V. 
 V. 

V.