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Timestamp: 2019-04-20 00:27:15+00:00

Document:
MCR synthesis of a tetracyclic tetrazole scaffold.
Patil P, Khoury K, Herdtweck E, Dömling A.
Bioorg Med Chem. 2014 Dec 20. pii: S0968-0896(14)00869-4. doi: 10.1016/j.bmc.2014.12.021.
A universal isocyanide for diverse heterocycle syntheses.
Org Chem Front. 2014 Sep 1;1(7):834-837.
Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis.
Boltjes A, Liao GP, Zhao T, Herdtweck E, Dömling A.
Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor.
Boltjes A, Huang Y, van de Velde R, Rijkee L, Wolf S, Gaugler J, Lesniak K, Guzik K, Holak TA, Dömling A.
Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.
Huang Y, Wolf S, Beck B, Köhler LM, Khoury K, Popowicz GM, Goda SK, Subklewe M, Twarda A, Holak TA, Dömling A.
ACS Chem Biol. 2014 Mar 21;9(3):802-11.
The latest 20 years are displayed.
A. Dömling Beobachtung zur Elektrolytaufnahme bei Nymphalis antiopa L. ATALANTA, 1989, 20, 111.
A. Dömling, I. Ug, A New 5,6-Dihydro-2H-1,3-oxazine Synthesis via Asinger-type Condensation H Tetrahedron, 1993, 49, 9495-9500.
A. Dömling, I. Ugi Die Siebenkomponenten Reaktion Angewandte Chemie 1993, 105, 634-635.
A. Dömling, I. Ugi The seven component reaction Angewandte Chemie International Edition English 1993, 32, 563-564.
A. Dömling, M. Starnecker, I. Ugi β-Lactam-Nucleosid ChimereAngewandte Chemie 1995, 107, 2465.
A. Dömling, M. Starnecker, I. Ugi UThe β-Lactam-Nucleoside Chimera Angewandte Chemie International Edition English 1995, 34 , 2238-2239.
Formale Unterstützung bei Multikomponentenreaktionen – Automatisierung der SynthesechemieU In: Software – Entwicklung in der Chemie. R. Moll (Hrsg.), Frankfurt: Gesellschaft Deutscher Chemiker, 1995, S. 113-128. (Tagungsband zu GDCh-Workshop 16.-18.11.1994).
A. Dömling, A. Bayler, I. Ugi 2,5-Dihydro-4-hydroxymethyl-1,3-oxazoles by Asinger-Condensation Tetrahedron, 1995, 51, 755-760.
K. Kehagia, A. Dömling, I. Ugi The Formation of ß-Lactam Derivatives and a C3-Symmetrical Heterocycle from 5, 6-Dihydro-2H-1,3-oxazines Tetrahedron, 1995, 51, 139-144.
K. Kehagia, A. Dömling, I. Ugi, W. Hiller, J. Riede New synthesis and structure Determination of 13-Aza-4,4,8,8,12,12-hexamethyl-2,6,10-trioxatricyclo[7,3,1 05,13]tridecaneZeitschrift für Naturforschung 1995, 50b, 667-670.
I. Ugi, A. Dömling, M. Goebel, W. Hörl, K. Kehagia, S. Lehnhoff, M. Starnecker Flerkomponentsreaktioner ger nya läkemedel Kemisk Tidskrift, 1995, 4, 50-53.
A. Dömling, K. Kehagia, I. Ugi Employment of a Steroidal Aldehyde in a New Synthesis of ß-Lactam Derivatives Tetrahedron, 1995, 51, 9519-9522.
I. Ugi, M. Goebel, B. Gruber, M. Heilingbrunner, C. Heiß, W. Hörl, O. Kern, M. Starnecker, A. Dömling Molecular Libraries in Liquid Phase via Ugi-MCR, Research on Chemical IntermediatesU 1996, 22, 625 – 644.
A. Dömling, W. Richter, I. Ugi UCombinatorial Generation of Nucleobase Libraries by MCRU Nucleosides & Nucleotides, 1997, 16, 1753-1756.
J. Chattopadhyaya, A. Dömling, K. Lorenz, W. Richter, I. Ugi, B. Werner MCR III. Multicomponent rections and their Libraries. A New type of Organic Chemistry of the Isocyanides and Phosphorus derivatives Nucleosides & Nucleotides, 1997, 16, 843.
I. Ugi, M. Almstetter, B. Gruber, A. Dömling MCR X. Important Aspects for Automating Preparative MCR-Chemistry Springer Verlag, Berlin, 1998, S. 184-189, Dechema-Tagung, 23.-25.2.1997.
I. Ugi, M. Almstetter, H. Bock, A. Dömling, B. Ebert, B. Gruber, C. Hanusch-Kompa, S. Heck, K. Kehagia-Drikos, K. Lorenz, S. Papathoma, R. Raditschnig, T. Schmid, B. Werner, A. von Zychlinsk, MCR XVII. Three Types of MCR’s and the Libraries – their Chemistry of Natural Events and the Preparative Chemistry Croatica Chemica Acta, 1998, 71, 527-547.
A. Dömling, E. Herdtweck, I.Ugi MCR V.The Seven Component Reaction Acta Chemica Scandinavica, 1998, 52, 107-113.
A. Dömling A Novel Concept for the Combinatorial Synthesis of Peptide Nucleic Acids Nucleosides & Nucleotides, 1998, 17, 1667-1670.
K.-Z. Chi, A. Dömling, M. Barrère A Novel Method to Highly Versatile Monomeric PNA Building Blocks by Multi Component Reactions Bioorganic & Medicinal Chemistry Letters 1999, 9, 2871-2874.
S. Heck, A. Dömling A versatile multi-component one-pot thiazole synthesis Synlett, 2000, 434.
B. Beck, A. Dömling, S. Hess One-pot Synthesis and Biological Evaluation of Aspergillamid A and analogues Bioorganic & Medicinal Chemistry Letters 2000, 10, 1701-1705.
B. Beck, M. Magnin-Lachaux, E. Herdtweck, A. Dömling A Three Component Butenolide Synthesis Organic Letters, 2001, 3, 2875-2878.
J. Kolb, B. Beck, A. Dömling Simultaneous Assembly Of The b-Lactam And The Thiazole Moiety By A New Multicomponent Reaction Tetrahedron Letters 2002, 43, 6897-6901.
B. Henkel, M. Sax, A. Dömling New Method For The Preperation Of Solid-Phase Bound Isocyanocarboxylic Acids And Ugi Reactions Therewith Tetrahedron Letters 2003, 44, 7015.
B. Henkel, M. Sax, A. Dömling A New And Efficient Multicomponent Solid-Phase Synthesis Of 2-Acylaminomethylthiazoles Tetrahedron Letters 2003, 44, 3679.
B. Henkel, B. Westner, B. Beck, B. Mejat, A. Dömling Convergent Multicomponent Assembly Of 2-Acyloxymethyl Thiazoles Tetrahedron Letters 2003, 44, 8947.
U. Kusebauch, B. Beck, K. Messer, E. Herdtweck, A. Dömling Massive Parallel Catalyst Screening: Towards Asymmetric MCRs Organic Letters 2003, 5, 4021.
B. Henkel, B. Westner, A. Dömling Polymer-Bound 3-N,N-(Dimethylamino)-2-isocyanoacrylate for the Synthesis of Thiazoles via a Multicomponent Reaction Synlett 2003, 2410.
B. Beck, G. Larbig, B. Mejat, M. Magnin-Lachaux, A. Picard, E. Herdtweck, A. Dömling. Short and Diverse Route Toward Complex Natural Product-Like Macrocycles Organic Letters 2003, 5, 1047-1050.
J. Kolb, B. Beck, M. Almstetter, S. Heck, E. Herdtweck, A. Dömling New MCRs: The first 4-component reaction leading to 2,4-disubstituted thiazoles Molecular Diversity 2003, 6, 297-313.
Dömling, A; Beck, B; Schauer-Vukasinovic, V, Sakamuri S, Agrawal S, Sasse F, Mohamed-Wasim, Khalil M, Steinmetz H, Glaser G, Leibold T, Hofle G Tubulysins – a novel class of highly potent apoptosis inducing natural products. Clinical Cancer Research 2003, 9, 6132S.
B. Beck, A. Picard, E. Herdtweck, A. Dömling Highly Substituted Pyrrolidones And Pyridinones By 4-CR/2-CR Sequence Organic Letters 2004, 6, 39.
N. Yehia, W. Antuch, B. Beck, S. Hess, V. Schauer-Vukašinović, M. Almstetter, P. Furer, E. Herdtweck, A. Dömling Novel HIV Protease Inhibitors by MCR Bioorganic & Medicinal Chemistry Letters, 2004, 14, 3121.
K. Illgen, A. Dömling 1-Isocyano-2-dimethylamino-alkenes: Versatile Reagents in Organic Synthesis Synthesis, 2005, 11, 662.
A. Dömling, E. Herdtweck, S. Heck Cyanamid In Isocyanide-based MCRs Tetrahedron Letters 2005, 47, 1745.
G. Kaur, M. Hollingshead, S. Holbeck, V. Schauer- Vukašinović, R., F. Camalier, A. Dömling, S. Agarwal Biological Evaluation of Tubulysin A: a Potential Anticancer and Antiangiogenic Natural Product Biochemical Journal, 2006, 396, 235-242.
W. Antuch, S. Menon, Q.-Z. Chen, Y. Lu, S. Sakamuri, B. Beck, V. Schauer-Vukašinović, S. Agarwal, S. Hess, A. Dömling Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold Bioorganic & Medicinal Chemistry Letters, 2006, 6, 1740.
B. Beck, B. K. Mueller, A. Dömling Discovery of Pyrroloimidazoles as Neurit Outgrowth Stimulating Agents QSAR Combinatorial Chemistry 2006, 25, 527.
A. Dömling, B. Beck, Eichelberger, U., Sakamuri, S., S. Menon, Y. Lu, Q.-Z. Chi, L. Wessjohann. Totalsynthesis Of Tubulysin U and V Angewandte Chemie International Edition 2006, 43, 7235-7239.
M. de Greef, S. Abeln, K. Belkasmi, A. Dömling, R. V. A. Orru, L. A. Wessjohann, Rapid Combinatorial Access to Macrocyclic Ansa-Peptoids and Peptides with a Natural Product Like Core Structure Synthesis, 2006, 3997-4004.
A. Dömling, B. Beck, M. Magnin-Lachaux 1-Isocyanomethylbenzotriazole and 2,2,4,4-Tetramethylbutylisocyanide – Cleavable Isocyanides Useful for the Preparation of a-Aminomethyl Tetrazoles Tetrahedron Letter 2006, 47, 4289-4291.
S. Achatz, A. Dömling Desosamine in Multi Component Reactions Bioorganic Medicinal Chemistry Letters 2006, 16, 6360-6362.
A. Dömling, B. Beck, B. Baumbach Towards Erythropoietin mimicking Small Molecules Bioorganic Medicinal Chemistry Letters 2006, 17, 379.
A. Dömling, B. Beck, T. Fuchs, A. Yazbak Efficient Parallel Synthesis Of Arrays Of Amino Acid Derived Isocyano Amides Useful As Starting Materials In IMCR Journal of Combinatorial Chemistry 2006, 8, 872-880.
B. Beck, S. Srivastava, A. Dömling New End-On Thiolactone Scaffold by an Isocyanide-based Multicomponent Reaction Heterocycles 2007, 73, 177.
A. Dömling, W. Antuch, C. Oeffner, N. Yehia, B. Beck Parallel Synthesis Of Arrays Of 1,4,5-Trisubstituted 1-(4-Piperidyl)-Imidazoles By IMCR: A Novel Class Of Aspartyl Protease Inhibitors ARKIVOC 2007, 99.
A. Dömling; J. Achatz; B. Beck Novel Anti-Tuberculosis Agents from MCR Libraries. Bioorganic Medicinal Chemistry Letters 2007, 17, 5483.
A. Dömling, W. Antuch, B. Beck, V. Schauer-Vukašinović Isosteric Exchange Of The Acyl Sulfonamide Moiety In Abbott’s Bcl-XL Protein Interaction Antagonist Bioorganic Medicinal Chemistry Letters 2008, 18, 4115.
Bon, R. S.; Sprenkels, N. E.; Koningstein, M. M.; Schmitz, R. F.; Kanter, F. J., J.; Dömling, A.; Groen, M. B.; Orru, R. V. A. Efficient C2 functionalisation of 1H-2-imidazolines Organic Biomolecular Chemistry 2008, 6, 130.
A. Dömling, Botros, S. New schistosomiasis drugs. American Journal Tropical Medicine and Hygienie 2008, 79, 223.
Srivastava, S.; Beck, B.; Herdtweck, E.; Khoury, K.; Dömling, A. A NOVEL D-THIOLACTONE SCAFFOLD BY A VERSATILE INTRAMOLCULAR MULTICOMPONENT REACTION Heterocycles 2008, 77, 731-8.
W. Wang, A. Dömling Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation Journal Combinatorial Chemistry 2009, 11, 403-409.
C. M. Haney, C. Schneider, B. Beck, J. Brodsky, A. Dömling Identification of Hsp70 modulators through modeling of the substrate binding domain Bioorganic Medicinal Chemistry Letters 2009, 19, 3828-38.
M. Bista, K. Kowalska, W. Janczyk, A. Dömling, T. Holak Robust NMR Screening for Lead Compounds Using Tryptophan-Containing Proteins Journal American Chemical Society 2009, 131, 7500–7501.
S. Srivastava, B. Beck, W. Wang, A. Czarna, T. Holak, A. Dömling Rapid and efficient hydrophilicity tuning of p53/MDM2 antagonists Journal Combinatorial Chemistry 2009, 11, 631-639.
H. Liu, A. Dömling One-pot Synthesis Of Highly Functionalized Seleno Aminoacid Derivatives Chemical Biology & Drug Design 2009, 74, 302-308.
H. Liu, A. Dömling Efficient and Diverse Synthesis of Indole Derivatives Journal Organic Chemistry 2009, 74, 6895-8.
K. Wang, A. Dömling Cyanoacetamide MCR (I): Parallel Synthesis Of Cyanoacetamides. Journal Combinatorial Chemistry 2009, 11, 920-927.
W. Wang, E. Herdtweck, A. Dömling Polycyclic indole alkaloid-type compounds by MCR Chemical Communications 46, 2010, 770-772.
B. Beck, S. Srivastava, K. Khoury, E. Herdtweck, A. Dömling ONE-POT MULTICOMPONENT SYNTHESIS OF TWO NOVEL THIOLACTONE SCAFFOLDS Molecular Diversity 2010, 14, 479-491.
Meireles, L.; Dömling, A.; Camacho, C. J. ANCHOR database: A PDB-wide screening tool of protein-protein interactions for small molecule intervention. 2010, BMC Bioinformatics, 38 (Web Server issue):W407-W411; doi:10.1093/nar/gkq502.
W. Wang, S. Joyner, K.A.S. Khoury, A. Dömling (-)Bacillamide C: The Convergent Approach Organic & Biomolecular Chemistry, 2010, 529 – 532.
GM. Popowicz, A Czarna, S Srivastava, K Wang, W Wang, A Dömling, TA Holak Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug Discovery Cell Cycle, 2010, 9, 1104-1111.
K. Wang, A. Dömling Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles Chemical Biology & Drug Design 2010, 75, 227-283.
K. Wang, D. Kim, A. Dömling Cyanoacetamide MCR (III): Three-Component Gewald Reactions Revisited Journal Combinatorial Chemistry 2010, 12, 111-118.
Y. Huang, S. Wolf, L. Meireles, C. J. Camacho, T. Holak, A. Dömling 1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity Chemical Biology & Drug Design 2010, 76, 116-129.
Y. Huang, A. Dömling 1,4-Thienodiazepine-2,5-diones via MCR (II): Scaffold Hopping by Gewald and Ugi-Deprotection-Cyclization Strategy Chemical Biology & Drug Design 2010, 76, 130-141.
A. Czarna, B. Beck, S. Srivastava, G.M. Popowicz, S. Wolf, T Holak, A. Dömling Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists Angewandte Chemie, 2010, 49, 5342-5356.
H. Cao, H, Liu, A. Dömling Efficient MCR Synthesis of the Schistosomiasis Drug Praziquantel Chemistry-A European Journal, 2010, 16, 12296-98.
K. Wang, A. Dömling One-Pot Synthesis of 2-Amino-indole-3-carboxamides, Journal Combinatorial Chemistry 2010, 13, 140-146.
W. Wang, S. Ollio, E. Herdtweck, A. Dömling Polycyclic Compounds by Ugi-Pictet-Spengler Sequence Journal Organic Chemistry 2011, 76, 637-44.
I. Monfardini, J-W. Huang, B. Beck, J. F. Cellitti, M. Pellecchia, A. Dömling Screening Multicomponent Reactions for X-Linked Inhibitor of Apoptosis-Baculoviral Inhibitor of Apoptosis Protein Repeats Domain Binder Journal Medicinal Chemistry 2011, 54, 890-900.
J.-C. Rwigema, B. Beck, W. Wang, A. Dömling, M.W. Epperly, D. Shields, J. Goff, D. Franicola, T. Dixon, M.-C. Frantz, P. Wipf, Y. Tyurina, V.E. Kagan, H. Wang, J.S. Greenberger Two Strategies for the Development of Mitochondrion-Targeted Small Molecule Radiation Damage Mitigators. International Journal of Radiation Oncology, Biology, Physics 2011, 80, 860-868.
Y. Huang, S. Wolf, D. Koes, G. Popowicz, C. Camacho, T. Holak, A. Dömling. Exhaustive Fluorine Scanning towards Potent p53-Mdm2 Antagonists ChemMedChem, 2011, 7, 49 – 52).
Koes, D.; Khoury, K.; Huang, Y.; Wang, W.; Bista, M.; Popowicz, G.M.; Wolf, S.; Holak, T.A.; Dömling, A.; Camacho, C.J. Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists PLoS One 2012, 7(3): e32839. doi:10.1371/journal.pone.0032839.
H. Liu, S. William, E. Herdtweck, S. Botros, A. Dömling MCR Synthesis of Praziquantel Derivatives Chem. Biool. Drug Des. 2011, 79, 470-477.
K. Wang, E. Herdtweck, A. Dömling Cyanoacetamides (IV): Versatile One-Pot Route to 2-quinoline-3-carboxamides ACS Comb. Sci. 2012, 14, 316–322.
R. Arora, M. Shuda, A. Guastafierro, H. Feng, T. Topan, Y. Tolstov, D. Normolle, L.L. Vollmer, A. Vogt, A. Dömling, J.L. Brodsky, Y. Chang, P.S. Moore Survivin Is a Therapeutic Target in Merkel Cell Carcinoma. Science Translational Medicine 2012, 4, 133ra56.
W. Wang, H. Cao, S. Wolf, M. S. Camacho-Horvitz, T. A. Holak, A. Dömling Benzimidazol-2-one: A Novel Anchoring Principle For Antagonizing p53-Mdm2 Bioorganic Medicinal Chemistry 2012, asap.
S. Yerande, A. Ghaisas, K. Newase, W. Wang, K. Wang, A. Dömling (3 + 2) Annulation of amidinothioureas with binucleophile: Synthesis and antimicrobial of 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole derivatives J. Heterocycl. Chem. 2012 asap.
S. Yerande, C. Baviskar, K. Newase, W. Wang, K. Wang, A. Dömling Mercury (II) chloride Mediated Desulphurization of Amidinothioureas: Synthesis and Antimicrobial Activity of 3-Amino-1,2,4 Triazole Derivatives J. Heterocycl. Chem. 2012 asap.
S. G. Yerande, S. More, M. Bahandari, K. Newase, K. Khoury, K. Wang, A. Dömling A facile diversity oriented multicomponent one pot synthesis of 6,7- dihydrobenzo[c]thiophen-4(5H)-one derivatives from α-Oxo-N,S-ketene acetal J. Heterocycl. Chem. 2012 asap.
Y. Huang, K. Khoury, T. Chanas, A. Dömling Multicomponent Synthesis of Diverse 1,4-Benzodiazepine Scaffolds Org. Lett. 2012, 14, 5916-5919.
T. Zhao, A. Boltjes, E. Herdtweck, A. Dömling Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis Org. Lett. 2013, 15, 639-641.
M. Sinha, K. Khoury, E. Herdtweck, A. Dömling Polycyclic alkaloid type libraries by a novel combination of a Ugi variant and Pictet-Spengler reaction EJC 2013, in press.

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