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Timestamp: 2019-04-24 22:50:54+00:00

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Brown GC (2015) Living too long: The current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy. EMBO Rep. 16, 137-41.
Brown GC & Neher JJ (2014) Microglial phagocytosis of live neurons. Nat. Rev. Neurosci. 15, 209-216.
Tokatlidis K & Brown GC (2013) Focus on Mitochondria. FEBS J. 280:4932.
Borutaite V, Toleikis A, Brown GC (2013) In the eye of the storm: mitochondrial damage during heart and brain ischaemia. FEBS J. 280:4999-5014.
Neniskyte U & Brown GC (2013) Analysis of microglial production of reactive oxygen and nitrogen species. Methods Mol Biol. 1041:103-11.
Brown GC & Neher JJ (2012) Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’. Trends Biochem. Sci. 37, 325-332.
Neher JJ, Neniskyte U & Brown GC (2012) Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration. Front Pharmacol. 3:27.
Brown GC & Borutaite V (2012) There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion 12, 1-4.
Neher JJ, Brown GC, Kinsner-Ovaskainen A, Bal-Price A (2011), Inflammation and Reactive Oxygen/Nitrogen Species in Glial/Neuronal Cultures: Cell Culture Techniques, Neuromethods 56:331-347.
Brown GC (2011) Eaten alive: neuronal death by microglial phagocytosis during inflammatory neurodegeneration. Pharmacol. Rep. 63, 1270-1270.
Brown GC (2010) Nitric oxide and neuronal death. Nitric Oxide. 23:153-65.
Brown GC, Neher JJ. (2010) Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol. 41, 242-7.
Cooper C.E. & Brown G.C. (2008) The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. Journal of Bioenergetics and Biomembranes 40, 533-9.
Brown G. C. & Borutaite V. (2008) Regulation of apoptosis by the redox state of cytochrome c. Biochim Biophys Acta. 1777, 877-81.
Brown GC (2007) Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans. 35:1119-21.
Neher JJ, Brown GC (2007) Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system. Biochem Soc Trans. 35:1166-7.
Brown, G. C. (2007) Nitric oxide and mitochondria. Front. Biosci. 12, 1024-33.
Brown, G. C. & Borutaite, V. (2007) Nitric oxide and mitochondrial respiration in the heart. Cardiovascular Research 75, 283-90.
Brown G. C. (2007) Nitric oxide, hydrogen peroxide and peroxynitrite in inflammation. Inflammation Research 56, S169.
Brown, G. C. & Borutaite V. (2006) Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species. Biochem. Soc. Trans. 34, 953-956.
Borutaite, V. & Brown, G. (2005) What else has to happen for nitric oxide to induce cell death? Biochem Soc Trans. 33:1394-6.
Brown, G. C. (2005) Mitochondria and cell death: apoptosis and necrosis. The Biochemist 27, 15-18.
Brown, G. C. & Borutaite, V. (2004) Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim. Biophys. Acta 1658, 44-49.
Brown, G.C. (2003) NO says yes to mitochondria. Science 299, 838-9.
Brown, G.C. & Bal-Price, A. (2003) Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria. Mol. Neurobiol. 27, 325-55.
Brown, G. C. & Borutaite, V. (2003) Mitochondria in apoptosis of ischaemic heart. FEBS Lett. 541, 1-5.
Brown, G. C. & Borutaite, V. (2002) Nitric oxide inhibition of mitochondrial respiration and its role in cell death. Free Rad. Biol. Med. 33, 1440-1450.
Brown, G. C. & Borutaite, V. (2001) Nitric oxide, mitochondria and cell death. IUBMB Life, 52: 189-195.
Brown, G. C. (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim. Biophys. Acta 1504, 46-57.
Brown, G. C. (2000) Nitric oxide as a competitive inhibitor of oxygen consumption in the mitochondrial respiratory chain. Acta Physiol. Scand. 168, 667-674.
Soboll, S. & Brown, G. C. (2000) The use of in situ haemoglobin-free perfused liver in metabolic-control analysis. Biochem. Soc. Trans. 28, 109-113.
Brown, G. C. (2000) Energy, life and death. The Biochemist 22, 11-15.
Brown, G. C. (1999) Nitric oxide and mitochondrial respiration. Biochim. Biophys. Acta 1411, 351-369.
Bal-Price, A., Borutaite, V. & Brown, G. C. (1999) Mitochondia mediate nitric oxide-induced cell death. Ann. N. Y. Acad. Sci. 893, 376-378.
Brown, G. C. & Borutaite, V. (1999) Nitric oxide, cytochrome c and mitochondria. In Mitochondria and Cell Death (G. C. Brown, D. Nicholls & C. E. Cooper, eds.), Portland Press, London.
Brown, G. C. (1998) Nitric oxide interactions with mitochondria and oxygen metabolism. In: Nitric Oxide and the Cell (S. Moncada et al., eds.) pp. 31-39, Portland Press, London.
Brown, G. C., McBride, A. G., Fox, E. J., McNaught, K. St. P. & Borutaite, V. (1997) Nitric oxide and oxygen metabolism. Biochem. Soc. Trans. 25, 901-904.
Rolfe, D. F. S. & Brown, G. C. (1997) Cellular energy utilisation and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 77, 731-758.
Brown, G. C. (1997) Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, ischaemic, and neurodegerative pathologies. Mol. Cell. Biochem. 174, 189-192.
Borutaite, V., Morkuniene, R., Budriunaite, A. & Brown, G.C.(1996) Phenomenological kinetic analysis of ischaemic damage to heart mitochondria: role of calcium, fatty acids and cytochrome c. In BioThermoKinetics of the Living Cell (eds H.V. Westerhoff et al.) pp. 89-93.
Brown, G. C., Westerhoff, H. V. & Kholodenko, B. N. (1996) Molecular control analysis: Control within proteins and molecular processes. J. Theor. Biol. 182, 163-167.
Brown, G. C. (1996) Nitric oxide reversibly inhibits cytochrome oxidase, catalase and cell energy metabolism, and cytochrome oxidase rapidly reduces NO. in The Biology of Nitric Oxide part 5 (Stamler, J. et al, eds.), Portland Press, London.
Brown, G. C. (1995) The analysis of control and regulation in bioenergetics. In: Bioenergetics: a practical approach (eds. G. C. Brown & C. E. Cooper), pp. 111-131, IRL Press, Oxford.
Brown, G. C. (1995) Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett. 369, 136-139.
Cooper, C. E., Matcher, S. J., Wyatt, J. S., Cope, M.,Brown, G. C., Nemoto, E. M. & Delpy, D. T. (1994) Near infrared spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics. Biochem. Soc. Trans. 22, 974-980.
Brown, G. C. (1994) Phenomenological Kinetics and the Top-Down Approach to metabolic control analysis, In: Modern Trends in Biothermokinetics, (ed. Schuster, S. et al), pp. 225-228, Plenum Press, New York.
Brand, M. D. & Brown, G. C. (1994) The experimental application of control analysis to metabolic systems. In: Biothermodynamics (ed. H. V. Westerhoff), pp. 27-35, Intercept, Andover.
Brown, G. C. (1992) Control of respiration and ATP synthesis in mammalian mitochondria and cells, Biochem. J. 284, 1-13.
Brown, G. C. (1992) The leaks and slips of bioenergetic membranes, FASEB Journal 6, 2961-2965.
Brown, G. C., Hafner, R. P. & Brand, M. D. (1990). Monovalent cations and control of mitochondrial respiration. In: Monovalent Cations in Biological Systems (ed C. A. Pasternak), pp 237-251, CRC Press, Boca Raton.
Brown, G. C. (1988). The H+/e- forces and stoichiometries of the mitochondrial respiratory chain. In Integration of mitochondrial function (eds J. J. Lemasters, C. R. Hackenbrock and R. G. Thurman), pp 197-203, Plenum Press, New York.
Brand, M. D., Price, B. D. & Brown, G. C. (1986). Thermodynamics of electron transport between ubiquinone and cytochrome c catalysed by the mitochondrial cytochrome bc1 complex. in Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, North Holland.
Brown, G. C. (1986) Control of mitochondrial respiration. Ph. D. Thesis, University of Cambridge.
Brown, G. C. (1985). Control of mitochondrial respiration. In Recent Advances in Biological Membrane Studies (ed L. Packer), pp 463-477, Plenum Press, New York.
Brown G. C. (2008) The Long Game. The Guardian: Society, 10th September, p.1-2.
Brown G. (2007) Long life’s journey into death. Times Higher Education Supplement. 7th December.
Brown G. (2007) No way to go. The Guardian: SocietyGuardian. November 14th, p. 6, & The Guardian Weekly.
Brown G (2007) The bitter end. New Scientist 196, 42-43. (13 October 2007).
Brown, G. C. (2003) Capturing the brain, losing the mind. Cerebrum 5, 67-74.
Brown, G. C. (2000) Speed limits. The Sciences 40, 32-37.
Brown, G. C. (2000) Symbionts and assassins. Natural History 109, 66-71.
Mitochondrial function. (2010) Brown GC & Murphy MP, Essays in Biochemistry Series Volume 47, Portland Press, London.
The Living End: The Future of Death, Aging and Immortality. (2008) Brown G. Macmillan.
The Energy of Life. (1999) Brown G. Harper-Collins, London.
Mitochondria and Cell Death, (1999) Brown, G. C., Nicholls, D. & Cooper,C. E. eds. Portland Press, London.
Bioenergetics: a Practical Approach. (1995) Brown, G. C. & Cooper, C. E. eds. IRL Press, Oxford.
Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal Cell Death. Physiol Rev. 98:813-880.
Nomura K, Vilalta A, Allendorf DH, Hornik TC, Brown GC (2017) Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase. J Immunol. 198:4792-4801.
Métayer LE, Vilalta A, Burke GAA, Brown GC (2017) Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis. Oncotarget 8:60892-60903.
Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AM, Liu ZH, Shetty AJ, Tremoleda JL, Davies M, Deierborg T, Priestley JV, Brown GC, Michael-Titus AT, Venero JL, Burguillos MA (2017) Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Sci Rep. 7:41689.
Vilalta A, Brown GC (2017) Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease. FEBS J. 2017 Nov 10.
Brown GC, St George-Hyslop PH (2017) Deciphering microglial diversity in Alzheimer's disease. Science 356:1123-1124.
Neniskyte U, Fricker M, Brown GC (2016) Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase. Int J Biochem Cell Biol. 81:346-355.
Hornik TC, Vilalta A, Brown GC (2016) Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis. J Cell Sci. 129:65-79.
Brown GC, Vilalta A, Fricker M (2015) Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology. Curr Mol Med. 15:842-51.
Brown GC, Vilalta A (2015) How microglia kill neurons. Brain Res. 1628, 288-97.
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff, Karl Herrup, Sally A Frautschy, Bente Finsen, Guy C Brown, Alexei Verkhratsky, Koji Yamanaka, Jari Koistinaho, Eicke Latz, Annett Halle, Gabor C Petzold, Terrence Town, Dave Morgan, Mari L Shinohara, V Hugh Perry, Clive Holmes, Nicolas G Bazan, David J Brooks, Stéphane Hunot, Bertrand Joseph, Nikolaus Deigendesch, Olga Garaschuk, Erik Boddeke, Charles A Dinarello, John C Breitner, Greg M Cole, Douglas T Golenbock, Markus P Kummer (2015). Neuroinflammation in Alzheimer’s disease. Lancet Neurology 14, 388-405.
Neher JJ, Neniskyte U, Hornik T & Brown GC (2014) Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo, Glia 62:1463-75.
Neniskyte U, Vilalta A, Brown GC (2014) Tumour necrosis factor alpha induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett. 588:2952-6.
Vilalta A & Brown GC (2014) Deoxyglucose prevents neurodegeneration in culture by eliminating microglia. J Neuroinflammation. 11:58.
Hornik TC, Neniskyte U & Brown GC (2014) Inflammation induces Multinucleation of Microglia via PKC inhibition of Cytokinesis, generating highly phagocytic Multinucleated Giant Cells. J. Neurochem. 128, 650-661.
Neher JJ, Emmrich JV, Fricker M, Mander PK, Thery C, Brown GC (2013) Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci 110:E4098-107.
Emmrich J. Hornik T Neher J & Brown GC (2013) Rotenone induces neuronal death by microglial phagocytosis of neurons. FEBS J. 280, 5030-5038.
Neniskyte U, Brown GC (2013) Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β. J Neurochem. 126, 312-7.
Fricker M, Vilalta A, Tolkovsky AM, Brown GC (2013) Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. J Biol Chem. 288, 9145-52.
Fricker M, Oliva-Martin MJ, Brown GC (2012) Primary phagocytosis of viable neurons by microglia activated with LPS or Abeta is dependent on calreticulin/LRP phagocytic signalling. Journal of Neuroinflammation, 13, 9.
Fricker M, Neher JJ, Zhao JW, Théry C, Tolkovsky AM, Brown GC (2012) MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation. J Neurosci. 32, 2657-66.
Skemiene K, Rakauskaite G, Trumbeckaite S, Liobikas J, Brown GC, Borutaite V (2013) Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c. Int J Biochem Cell Biol. 45, 23-9.
Neniskyte U, Neher JJ, Brown GC. (2011) Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J Biol Chem. 286:39904-13.
Neher JJ, Neniskyte U, Zhao ZW, Bal-Price A, Tolkovsky AM & Brown GC (2011) Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J. Immunol. 186, 4973-83.
Barauskaite J, Grybauskiene R, Morkuniene R, Borutaite V, Brown GC (2011) Tetramethylphenylenediamine protects the isolated heart against ischaemia-induced apoptosis and reperfusion-induced necrosis. Br J Pharmacol. 162:1136-42.
Brown GC (2010) The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems. Biochem Soc Trans. 38:1210-4.
Brown RD, Burke GA, Brown GC (2009) Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine. Free Radic Biol Med. 46:1211-20.
Thompson AJ, Mander PK, Brown GC. (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br J Pharmacol. 158:1338-43.
Borutaite V, Morkuniene R, Arandarcikaite O, Jekabsone A, Barauskaite J & Brown GC. (2009) Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release. Journal of Biomedical Science 2009, 16:70.
Brown GC & Radcliffe SA (2009) Does the end of life have to be hell? Soundings 42, 67-78.
Brown GC, Borutaite V (2007) Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine (TMPD) via cytosolic cytochrome C redox state. J Biol Chem. 282, 31124-30.
Jekabsone, A., Nehrer, J., Borutaite, V. & Brown, G. C. (2007) Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase. J. Neurochem. 103, 346-356.
Jekabsone A, Mander PK, Tickler A, Sharpe M, Brown GC. (2006) Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. J Neuroinflammation. 3:24.
Borutaite, V., Hope, H., & Brown, G. C. (2006) Arachidonate and NADPH oxidase synergise with iNOS to induce death in macrophages: mechanisms of inflammatory degeneration. Pharmacol Rep. 58: 96-102.
Bal-Price, A., Garlton, J. & Brown, G. C. (2006) Nitric oxide stimulates PC12 cell proliferation via energy depletion. Nitric Oxide 14, 238-46.
Mander, P. K., Jekabsone, A. & Brown, G. C. (2006) Microglial proliferation is regulated by hydrogen peroxide from NADPH oxidase. J. Immunol. 176, 1046-52.
Borutaite, V. & Brown, G. C. (2006) S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production. Biochim. Biophys. Acta 1757, 562-6.
Kinsner, A., Monica Boveri, Lars Hareng, Stephanie Traub, Guy Brown, Sandra Coecke, Thomas Hartung and Anna Bal-Price (2006) Highly purified lipoteichoic acid induced proinflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. J. Neurochem. 99, 596-607.
Mander, P., Borutaite, V., Moncada, S. & Brown G. C. (2005) Nitric oxide from glial iNOS sensitizes neurons to hypoxic death via mitochondrial respiratory inhibition. J. Neurosci. Res. 79, 208-215.
Borutaite, V., Moncada, S. & Brown, G. C. (2005) Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition. Shock 23, 319-323.
Kinsner A, Pilotto V, Deininger S, Brown GC, Coecke S, Hartung T, Bal-Price A. (2005) Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation. J. Neurochem. 95, 1132-43.
Mander, P. K. & Brown, G.C. (2005) Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration. Journal of Neuroinflammation 2005, 2:20.
Jekabsone, A., Ivanoviene, L., Brown, G.C., Borutaite, V. (2003) Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release. J. Mol. Cell. Cardiol. 35. 803-809.
Borutaite, V. & Brown, G. C. (2003) Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion. Free Rad. Biol. Med. 35, 1457-68.
Jekabsone, A., Morkuniene, R., Brown, G.C., Borutaite, V. (2003) S-nitrosothiols, but not nitric oxide, induce cytochrome c release, mitochondrial dysfunction and caspase activation in perfused heart via mitochondrial permeability transition. Biochem. Pharmacol. 66, 1513-20.
Yung, H-W., Bal-Price, A.K., Brown, G.C. & Tolkovsky A.M. (2004) Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways. J. Neurochem. 89, 812-21.
Borutaite, V., Jekabsone, A., Morkuniene, R., Brown, G.C. (2003) Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J. Mol. Cell. Cardiol. 35, 357-366.
Golde, S., Chandran, S., Brown, G. C. & Compston, A. (2002) Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. J Neurochem. 82, 269-82.
Bal-Price, A., Moneer, Z. & Brown, G. C. (2002) Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes. Glia 40, 312-323.
Bal-Price, A. & Brown, G. C. (2002) Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. J. Neurochem. 80, 73-80.
Stewart VC, Heslegrave AJ, Brown GC, Clark JB, Heales SJ. (2002) Nitric oxide-dependent damage to neuronal mitochondria involves the NMDA receptor. Eur J Neurosci. 15, 458-464.
Borutaite, V. & Brown, G. C. (2001) Caspases are reversibly inactivated by hydrogen peroxide. FEBS Lett. 500, 114-8.
Bal-Price, A. & Brown, G. C. (2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia, inhibiting neuronal respiration, causing glutamate release and excitoxicity. J. Neuroscience 21, 6480-6491.
Borutaite, V., Budriunaite, A., Morkuniene, R. & Brown, G. C. (2001) Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by mycocardial ischaemia. Biochim. Biophys. Acta 1537, 101-109.
Borutaite, V., Matthias, A., Harris, H., Moncada, S. & Brown, G. C. (2001) Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation. Am. J. Physiol. 281, H2256-H2260.
Kholodenko, B.N., Brown, G.C, Hoek, J.B. Diffusion control of protein phosphorylation flux in signal transduction pathways. Biochem. J. (2000), 530, 901-907.
Bal-Price, A. & Brown, G. C. (2000) Nitric oxide induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J. Neurochem. 75, 1455-1464.
Borutaite, V., Budriunaite, A. & Brown, G. C. (2000) Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. Biochim. Biophys. Acta 1459,405-412.
Borutaite, V., Morkuniene, R. & Brown, G. C. (2000) Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms. FEBS Lett. 467, 155-159.
Brown, G. C. & Kholodenko, B. N. (1999) Spatial gradients of cellular phospho-proteins. FEBS Lett. 457, 452-454.
McBride, A. G., Borutaite, V. & Brown, G. C. (1999) Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death. Biochim. Biophys. Acta. 1454, 275-288.
Borutaite, V., Morkuniene, R. & Brown, G. C. (1999) Release of cytochrome c from heart mitochondria is induced by high calcium and peroxynitrite and is responsible for calcium-induced inhibition of substrate oxidation. Biochim. Biophys. Acta 1453, 41-48.
Clementi, E., Brown, G. C., Foxwell, N. & Moncada, S. (1999) On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc. Natl. Acad. Sci. USA 96, 1559-1562.
McNaught, K. St. P. & Brown, G. C. (1998) Nitric oxide causes glutamate release from brain synaptosomes following inhibition of mitochondrial function. J. Neurochem. 70, 1541-1546.
Clementi, E., Brown, G. C., Feelisch, M. & Moncada, S. (1998) Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl. Acad. Sci. 95, 7631-7636.
Soboll, S., Oh, M-H. & Brown, G. C. (1998) Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analysed by top-down metabolic control analysis. Eur. J. Biochem. 254, 194-201.
Kholodenko, B. N., Hoek, J. B., Brown, G. C. & Westerhoff, H. V. (1998) Control analysis of cellular signal transduction pathways. In: BioThermoKinetics in the Post Genomic Era (Larsson, C et al. eds.) Chalmers Reproservice, Gotenberg.
Brown, G. C. (1998) Evolutionary implications of metabolic control analysis for maximisation of rates of enzymes, pathways and physiological processes by natural selection. In: BioThermoKinetics in the Post Genomic Era (Larsson, C et al. eds.) Chalmers Reproservice, Gotenberg.
Korzeniewski, B. & Brown, G. C. (1998) Quantification of the relative contribution of parallel pathways to signal transfer: application to cellular energy transduction. Biophysical Chemistry 75, 73-80.
Brown, G. C., Foxwell, N. & Moncada, S. (1998) Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages. FEBS Lett.439, 321-324.
Brown, G. C., Hoek, J. B. & Kholodenko, B. N. (1997) Why do protein kinase cascades have more than one level? Trends Biochem. Sci. 22, 288.
Kholodenko, B. N., Hoek, J. B., Westerhoff, H. V. & Brown, G. C. (1997) Quantification of information transfer via cellular signal transduction pathways. FEBS Lett. 414, 430-434.
McBride, A. G. & Brown, G. C. (1997) Activation of human neutrophils causes rapid nitric oxide breakdown. FEBS Lett. 417, 231-234.
Penrice, J., Lorek, A., Cady, E. B., Amess, P. N., Wylezinska, M., Cooper, C. E., D'Souza, P., Brown, G. C., Kirkbride, V., Edwards, A. D., Wyatt, J. S. & Reynolds, E. O. R. (1997) Proton magnetic resonance spectroscopy of the brain during acute hypoxia-ischemia and delayed cerebral energy failure in the newborn piglet Pediatr. Res. 41, 795-802.
Borutaite, V., Morkuniene, R., Budriunaite, A., Krasauskaite, D., Ryselis, S., Toleikis, A. & Brown, G. C. (1996) Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischaemia. J. Mol. Cell. Cardiol. 28, 2195-2201.
Mildaziene, V., Baniene, R., Nauciene, Z., Marcinkeviciute, A., Borutaite, V., Kholodenko, B. & Brown, G. C. (1996) Ca2+ stimulates both respiratory and phosphorylation subsystems in heart mitochondria. Biochem. J. 320, 329-334.
Kholodenko, B. N. & Brown, G. C. (1996) Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? Biochem. J. 314, 753-760.
Borutaite, V. & Brown, G. C. (1996) Mitochondria rapidly reduce nitric oxide, and nitric oxide reversibly inhibits mitochondrial respiration. Biochem. J. 315, 295-299.
Brown, G.C. (1996) Information transfer via energy transducing pathways: Control of ATP turnover by ATP production. In: BioThermoKinetics of the Living Cell (eds H.V. Westerhoff et al.) pp. 71-74.
Kholodenko, B.N. & Brown, G.C. (1996) Extension of metabolic control analysis to physiology: control by body organs in vivo. In BioThermoKinetics of the Living Cell (eds H.V. Westerhoff et al.) pp. 163-167.
Mildaziene, V., Baniene, R., Nauciene, Z., Baker, B. M., Brown, G. C., Westerhoff, H. V. & Kholodenko, B. N. (1995) Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria. Archiv. Biophys. Biochem. 324, 130-134.
Brown, G. C. (1995) Reversible binding and inhibition of catalase by nitric oxide. Eur. J. Biochem. 232, 188-191.
Borutaite, V., Mildaziene, V., Brown, G. C. & Brand, M. D. (1995) Control and kinetic analysis of ischaemia-damaged heart mitochondria: which parts of the oxidative phosphorylation system are affected by ischemia? Biochim. Biophys. Acta 1272, 154-158.
Thorenson, M., Penrice, J., Lorek, A., Cady, E. B., Wylezinska, M., Kirkbride, V., Cooper, C. E., Brown, G. C., Edwards, A. D., Wyatt, J. S. & Reynolds, E. O. R. (1995) Mild hypothermia following severe transient hypoxia-ischaemia ameliorates delayed cerebral energy failure in the new born piglet. Pediatric Research, 37, 667-670.
Brown, G. C. (1995) Rate control within the Na+/glucose cotransporter. Biophys. Chem. 54, 181-189.
Brown, G. C., Bolanos, J. P., Heales, S. J. R. & Clark, J. B. (1995) Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Neuroscience Lett. 193, 201-204.
Cooper, C. E. & Brown, G. C. (1995) The interaction between nitric oxide and brain nerve terminals as studied by electron paramagnetic resonance. Biochem. Biophys. Res. Commun. 212, 404-412.
Mehmet, H. Yue, X., Squier, M. V., Cady, E., Penrice, J., Sarraf, C., Wylezinska, M., Kirkbride, V., Cooper, C., Brown, G. C., Wyatt, J. S., Reynolds, E. O. R. & Edwards, A. D. (1994) Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult. Neuroscience Lett. 181, 121-125.
Cady, E. B., Lorek, A., Penrice, J., Wylezinska, M., Cooper, C. E., Brown, G. C., Owen-Rice, H., Kirkbride, V., Wyatt, J. S.,Reynolds, E. O. R. (1994) Brain-metabolite transverse relaxation times in magnetic resonance spectroscopy increase as adenosine triphosphate depletes during secondary energy failure following hypoxia-ischaemia in the newborn piglet. Neuroscience Lett. 182, 201-204.
A.Loreck, Y.Takei, E.B.Cady, J.S.Wyatt, J.Penrice, A.D.Edwards, D.Peebles, M.Wylezinska, H.Owen-Reece, V.Kirkbride, C.E.Cooper, R.F.Aldridge, S.C.Roth, G.C. Brown, D.T.Delpy, & E.O.R.Reynolds (1994) Delayed ('secondary') cerebral energy failure following acute hypoxia-ischaemia in the newborn piglet: continuous 48-hour studies by phosphorous magnetic resonance spectroscopy. Pediatric Research 36, 699-706.
Brown, G. C. & Cooper, C. E. (1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356, 295-298.
Brown, G. C. (1994) Control analysis applied to the whole body: control by body organs over plasma concentrations and organ fluxes of substances in the blood, Biochem. J. 297, 115-122.
Brown, G. C. & Cooper, C. E. (1994) The analysis of rate-limitation within enzymes: relations between flux control coefficients of rate constants and unidirectional rates, rate constants and thermodynamic parameters of single isolated enzymes. Biochem. J. 300, 159-164.
Kholodenko, B. N., Westerhoff, H. V. & Brown, G. C. (1994) Rate limitation within a single enzyme is directly related to enzyme intermediate levels, FEBS Lett. 349, 131-134.
McCormick, D. C., Edwards, A. D., Brown, G. C., Wyatt, J. S., Potter, A., Cope, M., Delpy, D. T. & Reynolds, E. O. R.(1993) Effect of Indomethacin on Cerebral Oxidised Cytochrome Oxidase in Preterm Infants, Pediatric Research 33, 603-608.
Brown, G. C. & Cooper, C. E. (1993) Control analysis applied to single enzymes: can an isolated enzyme have a unique rate-limiting step?, Biochem. J. 294, 87-94.
Brown, G. C. (1991) Total cell protein concentration as an evolutionary constraint on the metabolic control distribution in cells, J. theor. Biol. 153, 195-203.
Edwards, A. D., Brown, G. C., Cope, M., Wyatt, J. S., McCormick, D. C., Roth, D. T. & Reynolds, E. O. R. (1991) Quantification of concentration changes in neonatal human cerebral oxidized cytochrome oxidase, J. Appl. Physiol. 71, 1907-1913.
Brown, G. C., Crompton, M. & Wray, S. (1991) Cytochrome oxidase content of rat brain during development, Biochim. Biophys. Acta 1057, 273-275.
Brown, G. C. & Brand, M. D. (1991) On the nature of the mitochondrial proton leak. Biochim. Biophys. Acta 1059, 55-62.
Brown, G. C. (1990) Electrostatic coupling between membrane proteins, FEBS Lett. 260, 1-5.
Brown, G. C., Hafner, R. P. & Brand, M. D. (1990) A top-down approach to the determination of control coefficients in metabolic control theory, Eur. J. Biochem. 188, 321-319.
Hafner, R. P., Brown, G. C. & Brand, M. D. (1990) Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and proton motive force in isolated mitochondria using the top-down approach of metabolic control theory, Eur. J. Biochem. 188, 313-319.
Nobes, C. D., Brown, G. C., Olive, P. N. & Brand, M. D. (1990) Non-ohmic proton conductance of the mitochondrial inner membrane in hepatoytes, J. Biol. Chem. 265, 12903-09.

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