Source: https://www.institutcochin.fr/la-recherche/drc/equipe-v-boeva?set_language=fr
Timestamp: 2019-04-21 12:16:43+00:00

Document:
Investigate the consequences of somatic genomic alterations on the epigenetic landscape in cancer.
We are currently interested in understanding the oncogenic processes related to two cancer types: neuroblastoma and adrenocortical carcinoma.
Our methodological research is centered on data integration and the development of high throughput data analysis methods to study regulation in cancer with a special focus on epigenetic regulation.
The team is a laureate of ATIP-Avenir Young group leader Program 2016.
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. V. Boeva, C. Louis-Brennetot, A. Peltier, S. Durand, C. Pierre-Eugène, V. Raynal, H. Etchevers, S. Thomas, A. Lermine, E. Daudigeos-Dubus, B.Geoerger, M.F. Orth, T.G.P. Grünewald, E. Diaz, B. Ducos, D. Surdez, A.M. Carcaboso, I. Medvedeva, T. Deller, V. Combaret, E. Lapouble, G. Pierron, S. Grossetête-Lalami, S. Baulande, G. Schleiermacher, E. Barillot, H. Rohrer, O. Delattre, and I. Janoueix-Lerosey. Nature Genetics, 2017 Sep;49(9):1408-1413.
HMCan-diff: a method to detect changes in histone modifications in cells with different genetic characteristics. Ashoor H, Louis-Brennetot C, Janoueix-Lerosey I, Bajic VB, Boeva V.
RNF: a general framework to evaluate NGS read mappers. K. Brinda, V. Boeva, and G. Kucherov. Bioinformatics. 2016. 32(1):136-9.
HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data. H. Ashoor, A. Hérault, A. Kamoun, F. Radvanyi, V.B. Bajic, E. Barillot and V. Boeva. Bioinformatics, 2013, 29 (23): 2979-2986.
Chimeric oncogene regulates the EGR2 sarcoma susceptibility gene via a GGAA-microsatellite. T.G.P. Grünewald, V. Bernard, P. Gilardi-Hebenstreit, V. Raynal, D. Surdez, M.-M. Aynaud, O. Mirabeau, F. Cidre-Aranaz, F. Tirode, S. Zaidi, G. Perot, A.H. Jonker, C. Lucchesi, M.-C. Le Deley, O. Oberlin, P. Marec-Bérard, A.S. Véron, S. Reynaud, E. Lapouble, V. Boeva, T. Rio Frio, J. Alonso, S. Bhatia, G. Pierron, G. Cancel-Tassin, O. Cussenot, D.G. Cox, L.M. Morton, M.J. Machiela, S.J.Chanock, P. Charnay and O. Delattre. Nature Genetics. 2015 Sep;47(9):1073-8.
Jarid2 is implicated in the initial Xist-induced targeting of PRC2 to the inactive X chromosome. S.T. da Rocha, V. Boeva, M. Escamilla-Del-Arenal, K. Ancelin, C. Granier, N. Reis Matias, S. Sanulli, J. Chow, E. Schulz, C. Picard, S. Kaneko, K. Helin, D. Reinberg, A. F. Stewart, A. Wutz, R. Margueron and E. Heard. Molecular Cell, 2014, 53 (2): 301-316.

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