Source: https://vavilov.elpub.ru/jour/article/view/28
Timestamp: 2019-04-20 04:20:00+00:00

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Переход от вегетативной к репродуктивной стадии развития растений зависит от фотопериода и яровизации. Предложена простая логическая модель генной сети, регулирующей время цветения озимой пшеницы. У озимых сортов злаков чувствительность к яровизации контролируется генами VRN1, VRN2 и VRN3. После яровизации продукт гена VRN1 подавляет ген VRN2, кодирующий репрессор цветения. В результате уровень экспрессии VRN3 возрастает и стимулирует дальнейшее увеличение уровня транскрипции гена VRN1. Гены образуют петлю с положительной обратной связью,что усиливает транскрипцию VRN1 до уровня, необходимого для инициации цветения. В условиях длинного дня экспрессию VRN3 усиливают продукты генов PPD1 и CO2, определяющие чувствительность к фотопериоду. Сезонные изменения длины дня через фоторецепторы передаются циркадным часам, которые модулируют время цветения. Данные о генах ячменя и пшеницы, контролирующих чувствительность к яровизации и фотопериоду, интегрированы в генную сеть. С помощью синхронной булевой модели воспроизведена динамика генной сети. Расширенная модель генной сети может быть использована для проверки согласованности экспериментальных данных и выдвижения новых гипотез о взаимодействии генов.
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