Source: http://dopovidi-nanu.org.ua/en/archive/2017/10/13
Timestamp: 2019-04-22 15:57:16+00:00

Document:
Antibiotic batumin produced by Pseudomonas batumici has shown high activity against the type and reference strains and clinical isolates of 30 different species of the genus Staphylococcus (including MRSA and SSCVs). Batumin activity against these bacteria was 0.25—0.5 μg/ml. Batumin influence upon the biofilm formation by representatives of genus Staphylococcus has been studied. Presence of 0.125 μg /ml of batumin in the medium decreased the biofilm formation in 85 % of studied strains. Antibiotic effectiveness depended on the stage of its formation. Entry of batumin into the medium simultaneously with the bacterial culture promoted a decrease of the biofilm formation in all studied strains of staphylococci. The formed biofilm was more resistant to antibiotic. Breach of process of biofilm formation under the batumin influence was confirmed by the population analysis of studied staphylococci strains.
Kiprianova, E. A., Klochko, V. V., Zelena, L. B., Churkina, L. N. & Avdeeva, L. V. (2011). Pseudomonas batumici sp. nov., the antibiotic-producing bacteria isolated from soil of the Caucasus Black Sea coast. Microbiol. J., 73, No. 5, pp. 3-8.
Churkina, L., Kiprianova, E., Bidnenko, S., Marchenko, K. & Artysyuk, E. (2009). Antibiotic batumin for diagnostics of staphylococci and treatment of Staphylococcus aureus nasal carriage. Lik Sprava, No. 1-2, pp. 61-67.
Bukharin, O. V., Churkina, L. N., Perunova, N. B., Ivanova, E. V., Novikova, I. V., Avdeeva, L. V. & Yaroshenko, L. V. (2012). Influence of antistaphylococcus antiobiotic batumin on microorganism biofilm formation. Zh. Mikrobiol., Epidemiol., Immunobiol., No. 2, pp. 8-12 (in Russian).
Churkina, L. N., Bidnenko, S. I., Lopes dos Santos Santiago, G., Vaneechoutte, M., Avdeeva, L. V., Lutko, O. B.
Vandepitte, J., Engback, K., Piot, P. & Heuck, C. (1991). Basic Laboratory Procedures in Clinical Bacteriology. Geneva: WHO Library.
Clinical and Laboratory Standards Institute. (2005). Performance standards for antimicrobial susceptibility testing: fifteenths informational supplement. NCCLS document M 100 – S 15. Wayne, PA, USA.
Bidnenko, S. I., Lutko, O. B., Oserjanskaja, N. M. & Churkina, L. N. (2010). Microflora of periprosthetic tissues according to aseptic instability of hipendoprosthesis and features of its sensitivity to antibiotics. Biomed. Biosocial Anthropol., 15, pp. 87-91 (in Ukrainian).
Churkina, L. N. , Bidnenko, S. I., Makushenko, A. S., Vaneechoutte, M., Luitko, O. B., Ozeryanskaya, N. M.
& Avdeeva, L. V. (2010). Characteristics of atypical forms of staphylococci (SCVs), isolated from patients with osteomielitis. Antibiotiki i himioterapiya, 55, No. 5-6, pp. 36-40 (in Russian).
Lee, V. E. & O'Neill, A. J. (2016). Batumin does not exert its antistaphylococcal effect through inhibition of aminoacyl-tRNA synthetaseInt enzymes. J. Antimicrob. Agents., 49, Iss. 1, pp. 121-122.

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