Source: http://ppam.inflpr.ro/TE_41_ro.htm
Timestamp: 2019-04-26 15:51:53+00:00

Document:
The new trend in the era we live, e.g. tobacco use, dietary customs, and physical inactivity is responsible for the major killers worldwide - the hypertensive heart diseases. This lead to the development of new pharmaceutical forms with improved bioavailability and stable dosage by using clean technologies. Among these, transdermal patches gained popularity, being nowadays developed for everything, i.e. from contraception to Parkinson's disease. Although significant advances have been directed towards the fabrication of transdermal patches for hypertensive heart diseases, so far the already available transdermal patches present a large series of limitations. This is due to the large number of requirements they have to fulfill: the fabrication of a drug delivery system that meets all the stringent needs specific to the drug molecule, they have to be comfortable and cosmetically appealing, scale-up and manufacturability, and most important, economical. This project, through its team of six young researchers and one senior scientist, aims at using an alternative technology (i.e. MAPLE) to prepare in a quick and one-step procedure a new generation transdermal patches with Captopril as active compound, for hypertensive heart diseases, in order to overcome its side effects by oral application. Such developments of an improved state-of-the-art transdermal patch by means of MAPLE promise to be a breakthrough in the field of medicine, biotechnology, and polymer science.
Obiectivul principal al acestui proiect este de a aplica o tehnologie alternativa, MAPLE (Evaporare laser pulsate asistata de o matrice) pentru a fabrica rapid si intr-un singur pas plasturi transdermici. Acesti plasturi contin substanta activa Captopril si vor fi folositi pentru tratarea hipertensiunii arteriale.
Anul I: Experimente MAPLE pentru depunerea de filme subtiri polimerice si amestecuri de polimeri. Caracterizarea chimica si morfologica a filmelor subtiri de polimeri depuse.
Anul II: Experimente MAPLE pentru depunerea de filme subtiri polimerice ce contin substanta activa Captopril. Analiza materialelor depuse (studii morfologice, aderenta, masuratori de unghi de contact, structura chimica, determinarea variatiilor de grosime si masa, determinarea incorporarii de substanta activa).
Anul III: Teste in vivo si ex vivo.
3. A. Palla Papavlu, L. Rusen, V. Dinca, M. Filipescu, T. Lippert, M. Dinescu, Characterization of ethylcellulose and hydroxypropyl methylcellulose thin films deposited by matrix-assisted pulsed laser evaporation, Applied Surface Science 302: 87-91 (2014).
fabrication of polymeric transdermal drug-delivery system incorporating Captopril, A. Palla-Papavlu, V. Dinca, M. Filipescu, C. Luculescu, L. Rusen, T. Lippert, M.
Papavlu, L. Rusen, V. Dinca, M.
Papavlu, C. Luculescu, V. Ion, A.
V. Dinca, A. Palla Papavlu, A.
A. Palla Papavlu, V. Dinca, M.
evaporation, A. Palla Papavlu, V.
A. Palla Papavlu, I. Tirca, M.
applications, A. Palla Papavlu, J.
Chen, A. Woakaun, T. Lippert, M.

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