Source: https://people.epfl.ch/159115
Timestamp: 2019-04-24 22:23:28+00:00

Document:
- Provide Image Analysis Tools and Education to the collaborators of the EPFL Life Sciences section through the BioImaging and Optics Core Facility.
- Complete Masters studies in the EPFL Life Sciences Section.
In Prof. Vassily Hatzimanikatis's Group, the LCSB - Laboratory of Computational Systems Biology.
- Providing website management, update, creation and maintenance services using Jahia, PHP, MySQL for Symposiums and Meetings or Laboratories of the EPFL School of Life Sciences.
- Providing assistance to webmasters and coders for successful website development.
These websites were either created by me (Using PHP and MySQL) or were created using a Content Management System (Jahia). The management system, as well as the scripts are all tailored to the needs of the website, which allows for specific options to be available for each site independently.
Moreover, through these websites, I have developed a series of scripts and classes for the registration and abstract submission of symposium participants.
Linked to these are classes to allow visualisation of inscriptions, extractions for nametags and abstract books (in XML) and for most of these, I have also worked on the generation of the abstract book through either LaTeX or Adobe InDesign.
P. Solanes; B. Pan; P. Aebischer; J. R. Holt; B. Schneider : Cas9/gRNAs Selective Targeting of the Beethoven Tmc-1 Mutant Allele for Treating Progressive Hearing Loss by AAV-Based Delivery. 2018-05-01. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Chicago, IL, May 16-19, 2018. p. 138-139.
H. Lei; E. A. Dirren; C. Poitry-Yamate; B. Schneider; R. Gruetter et al. : Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. 2018.
T. Aebischer; G. Siguindo; E. Rochat; M. Arandjelovic; A. Heilman et al. : First quantitative survey delineates the distribution of chimpanzees in the Eastern Central African Republic; Biological Conservation. 2017. DOI : 10.1016/j.biocon.2017.06.031.
J. Aebischer; B. Schneider; C. Rochat ; Bicistronic aav vector for rna interference in als. WO2017013252 ; EP3121284 . 2017.
L. Zheng; N. Bernard-Marissal; N. Moullan; D. D'Amico; J. Auwerx et al. : Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons; Human Molecular Genetics. 2017. DOI : 10.1093/hmg/ddw418.
D. Ryu; L. Mouchiroud; P. A. Andreux; E. Katsyuba; N. Moullan et al. : Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents; Nat Med. 2016. DOI : 10.1038/nm.4132.
P. Machler; M. T. Wyss; M. Elsayed; J. Stobart; R. Gutierrez et al. : In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons; Cell Metabolism. 2016. DOI : 10.1016/j.cmet.2015.10.010.
J. Bobela-Aebischer; C. Rochat; N. Bernard-Marissal; P. Aebischer; B. L. Schneider : Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis. 2016. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, MAY 04-07, 2016. p. S240-S240.
A. Lathuiliere; V. Laversenne; A. Astolfo; E. Kopetzki; H. Jacobsen et al. : A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies; Brain. 2016. DOI : 10.1093/brain/aww036.
A. Emde; C. Eitan; L.-L. Liou; R. T. Libby; N. Rivkin et al. : Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS; Embo Journal. 2015.
W. Bobela; P. Aebischer; B. L. Schneider : Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease; Biomolecules. 2015. DOI : 10.3390/biom5042675.
E. Dirren; J. Aebischer; C. Rochat; C. Towne; B. L. Schneider et al. : SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice; Annals Of Clinical And Translational Neurology. 2015. DOI : 10.1002/acn3.162.
C. Askew; C. Rochat; B. Pan; Y. Asai; H. Ahmed et al. : Tmc gene therapy restores auditory function in deaf mice; Science Translational Medicine. 2015. DOI : 10.1126/scitranslmed.aab1996.
H. Lei; E. Dirren; B. Schneider; S. Aebischer; R. Gruetter : Noninvasive assessment of presymptomatic and symptomatic metabolic changes in the brain and brainstem of an ALS mouse model. 2015. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, AUG 23-27, 2015. p. 339-340.
T. Sotelo-Hitschfeld; M. I. Niemeyer; P. Maechler; I. Ruminot; R. Lerchundi et al. : Channel-Mediated Lactate Release by K+-Stimulated Astrocytes; Journal Of Neuroscience. 2015. DOI : 10.1523/Jneurosci.5036-14.2015.
S. Yang; M. Cacquevel; L. M. Saksida; T. J. Bussey; B. L. Schneider et al. : Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology; Experimental neurology. 2015. DOI : 10.1016/j.expneurol.2014.11.013.
J. Dusonchet; H. Li; M. Guillily; M. Liu; K. Stafa et al. : A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity; Human Molecular Genetics. 2014. DOI : 10.1093/hmg/ddu202.
B. Otsmane; A. Moumen; J. Aebischer; E. Coque; C. Sar et al. : Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively; Embo Reports. 2014. DOI : 10.1002/embr.201337948.
E. Dirren; C. L. Towne; V. Setola; D. E. J. Redmond; B. L. Schneider et al. : Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type-Specific Transgene Expression in the Spinal Cord; Human Gene Therapy. 2014. DOI : 10.1089/hum.2013.021.
A. Kaplan; K. J. Spiller; C. Towne; K. C. Kanning; G. T. Choe et al. : Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration; Neuron. 2014. DOI : 10.1016/j.neuron.2013.12.009.
A. Lathuiliere; B. Bohrmann; E. Kopetzki; C. Schweitzer; H. Jacobsen et al. : Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation; Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.10.026.
B. Otsmane; J. Aebischer; A. Moumen; C. Raoul : Cerebrospinal fluid-targeted delivery of neutralizing anti-IFN gamma antibody delays motor decline in an ALS mouse model; Neuroreport. 2014. DOI : 10.1097/Wnr.0000000000000043.
A. Lathuilière; S. Cosson; M. Lütolf; B. Schneider; P. Aebischer : A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells; Biomaterials. 2014. DOI : 10.1016/j.biomaterials.2013.09.071.
D. Krakora; P. Mulcrone; M. Meyer; C. Lewis; K. Bernau et al. : Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model; Molecular Therapy. 2013. DOI : 10.1038/mt.2013.108.
K. Loew; P. Aebischer; B. L. Schneider : Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles; Human Gene Therapy. 2013. DOI : 10.1089/hum.2012.174.
E. Dassie; M. R. Andrews; J.-C. Bensadoun; M. Cacquevel; B. L. Schneider et al. : Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model; Neurobiology Of Aging. 2013. DOI : 10.1016/j.neurobiolaging.2012.11.011.
P. Coune; M. Craveiro; M. Gaugler; V. Mlynárik; B. Schneider et al. : An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker; NMR in biomedicine. 2013. DOI : 10.1002/nbm.2817.
P. G. Coune; B. L. Schneider; P. Aebischer : Parkinson's Disease: Gene Therapies; Cold Spring Harbor Perspectives In Medicine. 2012. DOI : 10.1101/cshperspect.a009431.
B. Fanaroff; P. Aebischer; R. Camacho; I. Serageldin; N. Suetin et al. : How to build science capacity; Nature. 2012. DOI : 10.1038/490331a.
K. Loew; P. Aebischer : Use of viral vectors to create animal models for Parkinson's disease; Neurobiology Of Disease. 2012. DOI : 10.1016/j.nbd.2011.12.038.
B. R. Pinzer; M. Cacquevel; P. Modregger; S. A. McDonald; J. C. Bensadoun et al. : Imaging brain amyloid deposition using grating-based differential phase contrast tomography; Neuroimage. 2012. DOI : 10.1016/j.neuroimage.2012.03.029.
M. N. Gaugler; O. Genc; W. Bobela; S. Mohanna; M. T. Ardah et al. : Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity; Acta Neuropathologica. 2012. DOI : 10.1007/s00401-012-0963-y.
P. Aebischer : Philanthropy: The price of charity; Nature. 2012. DOI : 10.1038/481260a.
C. Ciron; S. Lengacher; J. Dusonchet; P. Aebischer; B. Schneider : Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function; Human Molecular Genetics. 2012. DOI : 10.1093/hmg/ddr618.
O. Marroquin; P. Aebischer; M. Molinari; N. Bouche ; System and Method For In Vivo Delivery of Antibodies and Fragments Thereof. US2011106062 . 2011.
V. Mlynarik; L. Sun-Reimer; S. Janssens; M. Cacquevel; H. Lei et al. : Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease. 2011. ISMRM 19th Annual Meeting & Exhibition, Montreal, Canada, May 7-13, 2011.
H. Lei; E. Dirren; C. Poitry-Yamate; B. Schneider; P. Aebischer et al. : Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET. 2011. 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011, Montréal, Québec, Canada.
P. G. Coune; J.-C. Bensadoun; P. Aebischer; B. Schneider : Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease; Journal of Parkinson's Disease. 2011. DOI : 10.3233/JPD-2011-11058.
O. Marroquin Belaunzaran; M. I. Cordero; V. Setola; S. Bianchi; C. Galli et al. : Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool; Plos One. 2011. DOI : 10.1371/journal.pone.0018268.
J. Dusonchet; O. Kochubey; K. Stafa; S. M. Young; R. Zufferey et al. : A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2; Journal of Neuroscience. 2011. DOI : 10.1523/JNEUROSCI.5092-10.2011.
R. Mastroeni; C. Raoul; P. Aebischer; J.-C. Bensadoun ; Use of igf-1 and nt-3 in the treatment of x-linked adrenoleukodystrophy. WO2010089706 . 2010.
M. Gaugler; P. G. Coune; S. Mohana; O. Genc; O. El-Agnaf et al. : Alpha-Synuclein Animal Models. 2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S606-S606.
P. Aebischer; E. Pino; M. Cacquevel; B. Schneider : Effective Delivery of the Neuroprotectant to the Brain. 2010. 2nd World Parkinson Congress, Glasgow, UK, September 28 - October 1, 2010. p. S602-S602.
C. Towne; V. Setola; B. L. Schneider; P. Aebischer : Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice; Molecular therapy : the journal of the American Society of Gene Therapy. 2010. DOI : 10.1038/mt.2010.260.
P. Aebischer : Neurodegenerative Disorders: Gene Therapy on Clinical Trial; Frontiers in Neuroscience. 2010.
K. Langou; A. Moumen; C. Pellegrino; J. Aebischer; I. Medina et al. : AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway; Journal of Neurochemistry. 2010. DOI : 10.1111/j.1471-4159.2010.06806.x.
L. Duplan; N. Bernard; W. Casseron; K. Dudley; E. Thouvenot et al. : Collapsin response médiator protein 4a(CRMP 4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron death; The Journal of Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5411-09.2010.
C. Towne; B. Schneider; D. Kieran; D. Redmond; P. Aebischer : Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6; Gene Therapy. 2010. DOI : 10.1038/gt.2009.119.
K. E. Paleologou; A. Oueslati; G. Shakked; C. C. Rospigliosi; H.-Y. Kim et al. : Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010. DOI : 10.1523/JNEUROSCI.5922-09.2010.
J. R. Sladek; J. D. Elswonh; R. H. Roth; C. Leranth; T. J. Collier et al. : Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman Primate. 2009. 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, Apr 30-May 02, 2009. p. 234-235.
D. J. Redmond; J. Elsworth; R. Roth; C. Leranth; T. Collier et al. : Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF; Journal of Comparative Neurology. 2009. DOI : 10.1002/cne.22028.
Y. Chu; H. Dodiya; P. Aebischer; C. Olanow; J. Kordower : Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions; Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.05.023.
M. Emborg; J. Moirano; J. Raschke; V. Bondarenko; R. Zufferey et al. : Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF; Neurobiology of Disease. 2009. DOI : 10.1016/j.nbd.2009.07.022.
A. Ulusoy; G. Shain; T. Björklund; P. Aebischer; D. Kirik : Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons; Molecular Therapy. 2009. DOI : 10.1038/mt.2009.142.
C. Blockeel; P. Mock; G. Verheyen; N. Bouche; P. Le Goff et al. : An in vivo culture system for human embryos using an encapsulation technology: a pilot study; Human Reproduction. 2009. DOI : 10.1093/humrep/dep005.
V. Perrin; N. Dufour; C. Raoul; R. Hassig; E. Brouillet et al. : Implication of the JNK pathway in a rat model of Huntington's disease; Experimental Neurology. 2009. DOI : 10.1016/j.expneurol.2008.10.008.
C. Towne; M. Pertin; A. Beggah; P. Aebischer; I. Decosterd : Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery; Molecular Pain. 2009. DOI : 10.1186/1744-8069-5-52.
R. Mastroeni; J.-C. Bensadoun; D. Charvin; P. Aebischer; A. Pujol et al. : Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model; Annals of Neurology. 2009. DOI : 10.1002/ana.21677.
C. Towne; P. Aebischer : Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi; Methods in molecular biology. 2009.
J. Dusonchet; J. Bensadoun; B. Schneider; P. Aebischer : Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease; Neurobiology of disease. 2009. DOI : 10.1016/j.nbd.2009.03.013.
I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne et al. : Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications; Journal of Virology. 2009. DOI : 10.1128/JVI.00001-09.
M. Bannwarth; I. Reis Correa Jr.; M. Sztretye; S. Pouvreau; C. Fellay et al. : Indo-1 derivatives for local calcium sensing; ACS Chemical Biology. 2009. DOI : 10.1021/cb800258g.
S. Azeredo da Silveira; B. Schneider; C. Cifuentes-Diaz; D. Sage; T. Abbas-Terki et al. : Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease; Human Molecular Genetics. 2009. DOI : 10.1093/hmg/ddn417.
M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes et al. : Intramuscular delivery of GDNF with human mesenchymal stem cells protects dying motor neurons and prolongs survival in a rat model of familial ALS. 2008. 15th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair, Clearwater Beach, FL, May 01-03, 2008. p. 482-483.
M. Pertin; C. Towne; T. Berta; A. Beggah; P. Aebischer et al. : Neuropathic pain: Gene therapy as a tool to transduce nociceptors. 2008. p. 12S-12S.
S. Jean; C. Towne; P. Aebischer; I. Decosterd : Feasibility of gene therapy for the treatment of neuropathic pain: downregulation of GTP cyclohydrolase 1 expression via RNA interference. 2008. p. 3S-3S.
F. Schwenter; S. Zarei; P. Luy; P. Morel; P. Aebischer et al. : Development Of A Cell Encapsulation Approach For Human Anti-Tumor Immunotherapy. 2008. XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies. p. 601-601.
O. Osetska; M. Albrecht; R. Froehlich; F. Gumy; A. Aebischer et al. : NIR-emitting lanthanide helicates. 2008. 235th American-Chemical-Society National Meeting, New Orleans, LA, Apr 06-10, 2008. p. INOR 245.
H. Runne; E. Régulier; A. Kuhn; D. Zala; O. Gokce et al. : Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry; The Journal of neuroscience. 2008. DOI : 10.1523/JNEUROSCI.3044-08.2008.
C. Lo Bianco; J. Shorter; E. Régulier; H. Lashuel; T. Iwatsubo et al. : Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease; The Journal of clinical investigation. 2008. DOI : 10.1172/JCI35781.
B. Schneider; M. Gaugler; P. Aebischer : Viral vectors: a potent approach to generate genetic models of Parkinson's disease; Parkinson's disease: Molecular and therapeutics insights from model systems; New York: Academic Press, 2008. p. 269-281.
B. Schneider; R. Zufferey; P. Aebischer : Viral vectors, animal models and new therapies for Parkinson's disease; Parkinsonism Realted Disorders. 2008. DOI : 10.1016/j.parkreldis.2008.04.024.
M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes et al. : Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS; Molecular Therapy. 2008. DOI : 10.1038/mt.2008.197.
N. Aebischer; N. Schmied : Eco-densité, une intervention durable en milieu urbain, Blackwall Reach East London (Londres, GB) ; 2008.
C. Towne; C. Raoul; B. L. Schneider; P. Aebischer : Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice; Mol Ther. 2008. DOI : 10.1038/mt.2008.73.
J. Szulc; P. Aebischer : Conditional gene expression and knockdown using lentivirus vectors encoding shRNA; Methods Mol Biol. 2008. DOI : 10.1007/978-1-60327-248-3_18.
M. E. Emborg; A. D. Ebert; J. Moirano; S. Peng; M. Suzuki et al. : GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys; Cell Transplant. 2008.
M. Bauer; J. Szulc; M. Meyer; C. H. Jensen; T. A. Terki et al. : Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons; J Neurochem. 2008. DOI : 10.1111/j.1471-4159.2007.05037.x.
P. Aebischer : From gene to gene therapy and pharmacotherapy, via transgenic animals. 2007. 11th Congress of the European-Federation-of-Neurological-Societies, Brussels, BELGIUM, Aug 25-28, 2007. p. 2-2.
O. F. Aebischer; A. Aebischer; B. Donnio; B. Alameddine; M. Dadras et al. : Controlling the lateral aggregation of perfluoroalkylated hexa-peri-hexabenzocoronenes; Journal of materials chemistry. 2007. DOI : 10.1039/b616057c.
M. Suzuki; J. McHugh; C. Tork; B. Shelley; S. M. Klein et al. : GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS; PLoS ONE. 2007. DOI : 10.1371/journal.pone.0000689.
B. L. Schneider; C. R. Seehus; E. E. Capowski; P. Aebischer; S. C. Zhang et al. : Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation; Hum Mol Genet. 2007. DOI : 10.1093/hmg/ddm008.
V. Perrin; E. Régulier; T. Abbas-Terki; R. Hassig; E. Brouillet et al. : Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease; Molecular Therapy. 2007. DOI : 10.1038/mt.sj.6300141.
S. Palfi; E. Brouillet; B. Jarraya; J. Bloch; C. Jan et al. : Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates; Mol Ther. 2007. DOI : 10.1038/sj.mt.6300185.
A. Consiglio; S. Martino; D. Dolcetta; G. Cusella; M. Conese et al. : Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts; J Neurol Sci. 2007. DOI : 10.1016/j.jns.2007.01.010.
E. E. Capowski; B. L. Schneider; A. D. Ebert; C. R. Seehus; J. Szulc et al. : Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy; J Neurosci Methods. 2007. DOI : 10.1016/j.jneumeth.2007.02.022.
N. Aebischer; J. Clerc; B. Mareine; P. Decaro : Arts martiaux du Japon: une évolution socio-culturelle ; 2007.
P. Aebischer; A. C. Kato : Playing Defense Against Lou Gehrig's Disease; Scientific American. 2007. DOI : 10.1038/scientificamerican1107-86.
M. Wiznerowicz; J. Jakobsson; J. Szulc; S. Liao; A. Quazzola et al. : The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis; Journal of Biological Chemistry. 2007. DOI : 10.1074/jbc.M705898200.
G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli et al. : Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems; Chemometrics and Intelligent Laboratory Systems. 2007. DOI : 10.1016/j.chemolab.2006.06.015.
J. Szulc; M. Wiznerowicz; M.-O. Sauvain; D. Trono; P. Aebischer : A versatile tool for conditional gene expression and knockdown; Nature Methods. 2006. DOI : 10.1038/nmeth846.
M. Dadras; O. Aebischer; B. Alameddine; T. Jenny; N. F. de Rooij : Cyro SEM: Application in Micro and Nanotechnology. 2006. p. 1822.
O. F. Aebischer; A. Aebischer; P. Tondo; B. Alameddine; M. Dadras et al. : Self-aggregated perfluoroalkylated hexa-peri-hexabenzocoonene fibers observed by cyro-SEM and fluorescence spectroscopy; Chemical Communication. 2006. DOI : 10.1039/b609056g.
C. Raoul; P. Aebischer : The potential of gene therapy for motor neuron diseases; Amyotrophic Lateral Sclerosis; New York, NY: Taylor&Francis, 2006. p. 505-524.
C. Raoul; S. D. Barker; P. Aebischer : Viral-based modelling and correction of neurodegenerative diseases by RNA interference; Gene therapy. 2006.
R. Pardo; E. Colin; E. Regulier; P. Aebischer; N. Deglon et al. : Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421; J Neurosci. 2006. DOI : 10.1523/JNEUROSCI.3706-05.2006.
J. Bensadoun; P. Aebischer : Viral vectors as a tool to model and treat Parkinson's disease; Wien Klin Wochenschr. 2006. DOI : 10.1007/s00508-006-0736-5.
M. Arango; S. Holbert; D. Zala; E. Brouillet; J. Pearson et al. : CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity; J Neurosci. 2006. DOI : 10.1523/JNEUROSCI.5409-05.2006.
A. Sajadi; J. Bensadoun; B. Schneider; C. Lo Bianco; P. Aebischer : Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease; Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.10.006.
J. L. Ridet; J. Bensadoun; N. Deglon; P. Aebischer; A. D. Zurn : Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease; Neurobiol Dis. 2006. DOI : 10.1016/j.nbd.2005.06.003.
W. E. Blanco-Bose; B. L. Schneider; P. Aebischer : Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants; Mol Ther. 2006. DOI : 10.1016/j.ymthe.2005.08.010.
P. V. Grundler; O. V. Yazyev; N. Aebischer; L. Helm; G. Laurenczy et al. : Kinetic studies on the first dihydrogen aquacomplex, [Ru(H2)(H2O)5]2+: Formation under H2 pressure and catalytic H/D isotope exchange in water; Inorganica Chimica Acta. 2006. DOI : 10.1016/j.ica.2005.06.056.
S. Behrstock; A. Ebert; J. McHugh; S. Vosberg; J. Moore et al. : Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates; Gene Ther. 2006. DOI : 10.1038/sj.gt.3302679.
C. Raoul; E. Buhler; C. Sadeghi; A. Jacquier; P. Aebischer et al. : Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL; Proc Natl Acad Sci U S A. 2006. DOI : 10.1073/pnas.0508774103.
S. M. Klein; S. Behrstock; J. McHugh; K. Hoffmann; K. Wallace et al. : GDNF delivery using human neural progenitor cells in a rat model of ALS; Hum Gene Ther. 2005. DOI : 10.1089/hum.2005.16.509.
E. Colin; E. Regulier; V. Perrin; A. Durr; A. Brice et al. : Akt is altered in an animal model of Huntington's disease and in patients; Eur J Neurosci. 2005. DOI : 10.1111/j.1460-9568.2005.03985.x.
Y. H. Ahn; J. Bensadoun; P. Aebischer; A. D. Zurn; A. Seiger et al. : Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor; Brain Res Bull. 2005. DOI : 10.1016/j.brainresbull.2005.04.009.
D. Zala; A. Benchoua; E. Brouillet; V. Perrin; M. C. Gaillard et al. : Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment; Neurobiol Dis. 2005. DOI : 10.1016/j.nbd.2005.05.017.
A. Sajadi; M. Bauer; B. Thony; P. Aebischer : Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production; J Neurochem. 2005. DOI : 10.1111/j.1471-4159.2005.03139.x.
C. Raoul; T. Abbas-Terki; J. Bensadoun; S. Guillot; G. Haase et al. : Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS; Nat Med. 2005. DOI : 10.1038/nm1207.
C. Raoul; P. Aebischer : ALS, IGF-1 and gene therapy: 'it's never too late to mend'; Gene Ther. 2004. DOI : 10.1038/sj.gt.3302204.
H. Kishima; T. Poyot; J. Bloch; J. Dauguet; F. Conde et al. : Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons; Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.03.012.
A. Sajadi; B. L. Schneider; P. Aebischer : Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease; Curr Biol. 2004. DOI : 10.1016/S0960-9822(04)00050-8.
F. Schwenter; B. L. Schneider; W. F. Pralong; N. Deglon; P. Aebischer : Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions; Hum Gene Ther. 2004. DOI : 10.1089/1043034041361172.
R. Zufferey; P. Aebischer : Salivary glands and gene therapy: the mouth waters; Gene Ther. 2004. DOI : 10.1038/sj.gt.3302321.
J. Bloch; A. C. Bachoud-Levi; N. Deglon; J. P. Lefaucheur; L. Winkel et al. : Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study; Hum Gene Ther. 2004. DOI : 10.1089/hum.2004.15.968.
D. Zala; J. Bensadoun; L. Pereira de Almeida; B. R. Leavitt; C. A. Gutekunst et al. : Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice; Exp Neurol. 2004. DOI : 10.1016/j.expneurol.2003.09.002.
S. Guillot; M. Azzouz; N. Deglon; A. Zurn; P. Aebischer : Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice; Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.01.017.
E. Regulier; D. Zala; P. Aebischer; N. Deglon : Lentiviral-mediated gene transfer to model triplet repeat disorders; Methods Mol Biol. 2004. DOI : 10.1385/1-59259-804-8:199.
C. Lo Bianco; B. L. Schneider; M. Bauer; A. Sajadi; A. Brice et al. : Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease; Proc Natl Acad Sci U S A. 2004. DOI : 10.1073/pnas.0405313101.
C. Lo Bianco; N. Deglon; W. Pralong; P. Aebischer : Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease; Neurobiol Dis. 2004. DOI : 10.1016/j.nbd.2004.06.008.
F. Schwenter; N. Bouche; W. F. Pralong; P. Aebischer : In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices; Biomaterials. 2004. DOI : 10.1016/j.biomaterials.2003.10.030.
R. Bjerkvig; T. A. Read; P. Vajkoczy; P. Aebischer; W. Pralong et al. : Cell therapy using encapsulated cells producing endostatin; Local Therapies for Glioma; New York, NY: Springer, 2003. p. 137-141.
B. L. Schneider; P. Aebischer : Cellular implants: pioneers in xenotransplantation?; Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.02086.x.
B. L. Schneider; F. Schwenter; W. F. Pralong; P. Aebischer : Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery; Mol Ther. 2003. DOI : 10.1016/S1525-0016(03)00055-8.
N. Deglon; V. Aubert; F. Spertini; L. Winkel; P. Aebischer : Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology; Xenotransplantation. 2003. DOI : 10.1034/j.1399-3089.2003.00110.x.
F. Schwenter; N. Deglon; P. Aebischer : Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy; J Gene Med. 2003. DOI : 10.1002/jgm.338.
E. Regulier; Y. Trottier; V. Perrin; P. Aebischer; N. Deglon : Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum; Hum Mol Genet. 2003. DOI : 10.1093/hmg/ddg305.
J. Bensadoun; L. Pereira de Almeida; E. G. Fine; J. L. Tseng; N. Deglon et al. : Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors; J Control Release. 2003. DOI : 10.1016/S0168-3659(02)00353-X.
C. Kostic; F. Chiodini; P. Salmon; M. Wiznerowicz; N. Deglon et al. : Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina; Gene Ther. 2003. DOI : 10.1038/sj.gt.3301948.
B. Schneider; P. Aebischer : Encapsulation as a strategy for cell xenotransplantation; Future strategies for tissue and organ replacement; London: Imperial College Press, 2002. p. 291-322.
N. Deglon; P. Aebischer : Lentiviruses as vectors for CNS diseases; Current topics in microbiology and immunology. 2002.
M. Pericin; A. Althage; S. Freigang; H. Hengartner; E. Rolland et al. : Allogeneic beta-islet cells correct diabetes and resist immune rejection; Proc Natl Acad Sci U S A. 2002. DOI : 10.1073/pnas.122241299.
S. Palfi; L. Leventhal; Y. Chu; S. Y. Ma; M. Emborg et al. : Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration; J Neurosci. 2002.
T. Ostenfeld; Y. T. Tai; P. Martin; N. Deglon; P. Aebischer et al. : Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons; J Neurosci Res. 2002. DOI : 10.1002/jnr.10396.
D. Boison; A. Huber; V. Padrun; N. Deglon; P. Aebischer et al. : Seizure suppression by adenosine-releasing cells is independent of seizure frequency; Epilepsia. 2002. DOI : 10.1046/j.1528-1157.2002.33001.x.
O. C. Aszmann; K. J. Korak; N. Kropf; E. Fine; P. Aebischer et al. : Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions; Plast Reconstr Surg. 2002. DOI : 10.1097/01.PRS.0000020990.82332.43.
B. Sommer; C. Rinsch; E. Payen; B. Dalle; B. Schneider et al. : Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts; Mol Ther. 2002. DOI : 10.1006/mthe.2002.0646.
T. Abbas-Terki; W. Blanco-Bose; N. Deglon; W. Pralong; P. Aebischer : Lentiviral-mediated RNA interference; Hum Gene Ther. 2002. DOI : 10.1089/104303402320987888.
L. P. de Almeida; C. A. Ross; D. Zala; P. Aebischer; N. Deglon : Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length; J Neurosci. 2002.
F. M. Barras; P. Pasche; N. Bouche; P. Aebischer; A. D. Zurn : Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat; J Neurosci Res. 2002. DOI : 10.1002/jnr.10434.
E. G. Fine; I. Decosterd; M. Papaloizos; A. D. Zurn; P. Aebischer : GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap; Eur J Neurosci. 2002. DOI : 10.1046/j.1460-9568.2002.01892.x.
E. Regulier; L. Pereira de Almeida; B. Sommer; P. Aebischer; N. Deglon : Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease; Hum Gene Ther. 2002. DOI : 10.1089/10430340260355383.
C. Rinsch; P. Dupraz; B. L. Schneider; N. Deglon; P. H. Maxwell et al. : Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia; Kidney Int. 2002. DOI : 10.1111/j.1523-1755.2002.kid574.x.
C. Lo Bianco; J. L. Ridet; B. L. Schneider; N. Deglon; P. Aebischer : alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease; Proc Natl Acad Sci U S A. 2002. DOI : 10.1073/pnas.152339799.
J. Tseng; P. Aebischer : Encapsulated cell implants as a novel treatment for Parkinson’s disease; Parkinson's disease: Methods and Protocols; Totowa, NJ: Humana Press, 2001. p. 279-288.
P. Aebischer; J. Ridet : Recombinant proteins for neurodegenerative diseases: the delivery issue; Trends in neurosciences. 2001. DOI : 10.1016/S0166-2236(00)01899-3.
A. D. Zurn; H. R. Widmer; P. Aebischer : Sustained delivery of GDNF: towards a treatment for Parkinson's disease; Brain Res Brain Res Rev. 2001. DOI : 10.1016/S0165-0173(01)00098-4.
A. Huber; V. Padrun; N. Deglon; P. Aebischer; H. Mohler et al. : Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy; Proc Natl Acad Sci U S A. 2001. DOI : 10.1073/pnas.131102898.
M. Emborg; N. Deglon; L. Leventhal; P. Aebischer; J. Kordower : Viral vector-mediated gene therapy for Parkinson's disease; Clin Neurosci Res. 2001. DOI : 10.1016/S1566-2772(01)00027-5.
B. L. Schneider; G. Peduto; P. Aebischer : A self-immunomodulating myoblast cell line for erythropoietin delivery; Gene Ther. 2001. DOI : 10.1038/sj.gt.3301356.
J. Bensadoun; L. P. de Almeida; M. Dreano; P. Aebischer; N. Deglon : Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome; Eur J Neurosci. 2001. DOI : 10.1046/j.0953-816x.2001.01802.x.
L. P. de Almeida; D. Zala; P. Aebischer; N. Deglon : Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease; Neurobiol Dis. 2001. DOI : 10.1006/nbdi.2001.0388.
J. Bloch; E. G. Fine; N. Bouche; A. D. Zurn; P. Aebischer : Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root; Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7778.
Y. Arsenijevic; J. G. Villemure; J. F. Brunet; J. J. Bloch; N. Deglon et al. : Isolation of multipotent neural precursors residing in the cortex of the adult human brain; Exp Neurol. 2001. DOI : 10.1006/exnr.2001.7691.
Y. Arsenijevic; S. Weiss; B. Schneider; P. Aebischer : Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2; J Neurosci. 2001. DOI : 10.1523/JNEUROSCI.21-18-07194.2001.
C. Rinsch; G. Peduto; B. L. Schneider; P. Aebischer : Inducing host acceptance to encapsulated xenogeneic myoblasts; Transplantation. 2001. DOI : 10.1097/00007890-200102150-00002.
C. Rinsch; P. Quinodoz; B. Pittet; N. Alizadeh; D. Baetens et al. : Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia; Gene Ther. 2001. DOI : 10.1038/sj.gt.3301436.
O. Jordan; P. Aebischer; J.-F. Clemence ; Pharmaceutical microencapsulation. US6080412 ; AU704240 ; MX9707492 ; EP0818993 ; AU5280396 ; CA2216359 ; WO9631199 . 2000.
J. L. Ridet; N. Deglon; P. Aebischer : Gene transfer techniques for the delivery of GDNF in Parkinson's disease; Novartis Foundation symposium. 2000.
V. Mittoux; J. M. Joseph; F. Conde; S. Palfi; C. Dautry et al. : Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease; Hum Gene Ther. 2000. DOI : 10.1089/10430340050015220.
C. Cisterni; C. E. Henderson; P. Aebischer; B. Pettmann; N. Deglon : Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors; J Neurochem. 2000. DOI : 10.1046/j.1471-4159.2000.0741820.x.
A. C. Bachoud-Levi; N. Deglon; J. P. Nguyen; J. Bloch; C. Bourdet et al. : Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF; Hum Gene Ther. 2000. DOI : 10.1089/10430340050111377.
G. Peduto; C. Rinsch; B. L. Schneider; E. Rolland; P. Aebischer : Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression; Transplantation. 2000.
J. Bensadoun; N. Deglon; J. L. Tseng; J. L. Ridet; A. D. Zurn et al. : Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF; Exp Neurol. 2000. DOI : 10.1006/exnr.2000.7409.
M. Azzouz; A. Hottinger; J. C. Paterna; A. D. Zurn; P. Aebischer et al. : Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2; Hum Mol Genet. 2000. DOI : 10.1093/hmg/9.5.803.
A. D. Zurn; H. Henry; M. Schluep; V. Aubert; L. Winkel et al. : Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells; Cell Transplant. 2000.
J. L. Tseng; P. Aebischer : Encapsulated neural transplants; Prog Brain Res. 2000.
A. F. Hottinger; M. Azzouz; N. Deglon; P. Aebischer; A. D. Zurn : Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus; Journal of Neuroscience. 2000.
J. C. Schense; J. Bloch; P. Aebischer; J. A. Hubbell : Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension; Nature biotechnology. 2000. DOI : 10.1038/74473.
N. Aebischer; R. Schibli; R. Alberto; A. E. Merbach : Complete carbonylation of fac-[Tc(H2O)3(CO)3]+ under CO pressure in aqueous media: a single sample story!; Angewandte Chemie, International Edition. 2000. DOI : 10.1002/(SICI)1521-3773(20000103)39:1<254::AID-ANIE254>3.0.CO;2-F.
N. Déglon; J. L. Tseng; J. Bensadoun; A. D. Zurn; Y. Arsenijevic et al. : Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease; Hum Gene Ther. 2000. DOI : 10.1089/10430340050016256.
J. H. Kordower; M. E. Emborg; J. Bloch; S. Y. Ma; Y. Chu et al. : Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease; Science. 2000. DOI : 10.1126/science.290.5492.767.
A. F. Hottinger; P. Aebischer : Treatment of diseases of the central nervous system using encapsulated cells; Adv Tech Stand Neurosurg. 1999.
J. W. Fitting; R. Paillex; L. Hirt; P. Aebischer; M. Schluep : Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis; Annals of Neurology. 1999. DOI : 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L.
C. Rinsch; B. L. Schneider; P. Aebischer : Highlights of the cell transplantation meeting at Montreux, March 1999; Cell Transplant. 1999.
N. Aebischer; A. E. Merbach : Reaction between [Ru(H2O)6]2+ and DMF: a complete volume profile of a monocomplex formation reaction on a d6 low spin aqua ion; Inorganic Reaction Mechanisms. 1999.
M. Borkenhagen; J. F. Clemence; H. Sigrist; P. Aebischer : Three-dimensional extracellular matrix engineering in the nervous system; J Biomed Mater Res. 1998. DOI : 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C.
J. L. Tseng; S. L. Bruhn; A. D. Zurn; P. Aebischer : Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy; Neuroreport. 1998. DOI : 10.1097/00001756-199806010-00027.
I. Decosterd; E. Buchser; N. Gilliard; J. Saydoff; A. D. Zurn et al. : Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain; Pain. 1998. DOI : 10.1016/S0304-3959(98)00044-X.
M. Borkenhagen; R. C. Stoll; P. Neuenschwander; U. W. Suter; P. Aebischer : In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel; Biomaterials. 1998. DOI : 10.1016/S0142-9612(98)00122-7.
A. D. Zurn; J. L. Tseng; N. Deglon; J. M. Joseph; P. Aebischer : A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease; Adv Pharmacol. 1998.
E. Regulier; B. L. Schneider; N. Deglon; Y. Beuzard; P. Aebischer : Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts; Gene Ther. 1998.
J. Bensadoun; O. Mirochnitchenko; M. Inouye; P. Aebischer; A. D. Zurn : Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice; Eur J Neurosci. 1998. DOI : 10.1046/j.1460-9568.1998.00345.x.
S. A. Makohliso; L. Giovangrandi; D. Leonard; H. J. Mathieu; M. Ilegems et al. : Application of Teflon-AF thin films for bio-patterning of neural cell adhesion; Biosens Bioelectron. 1998. DOI : 10.1016/S0956-5663(98)00036-0.
N. Aebischer; U. Frey; A. E. Merbach : Formation and in situ characterization of the first dihydrogen aqua complex: [Ru(H2O)5(H2)]2+; Chemical Communications. 1998.
N. Aebischer; R. Churlaud; L. Dolci; U. Frey; A. E. Merbach : Mechanism of Complex Formation of Ruthenium(II) Aquacomplexes with H2C:CH2, MeCN, Me2SO, and CO: Metal-Water Bond Rupture as Rate-Determining Step; Inorganic Chemistry. 1998. DOI : 10.1021/ic980628z.
N. A. Pochon; A. Menoud; J. L. Tseng; A. D. Zurn; P. Aebischer : Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization; Eur J Neurosci. 1997. DOI : 10.1111/j.1460-9568.1997.tb01623.x.
C. Rinsch; E. Regulier; N. Deglon; B. Dalle; Y. Beuzard et al. : A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension; Hum Gene Ther. 1997.
J. L. Tseng; E. E. Baetge; A. D. Zurn; P. Aebischer : GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine; J Neurosci. 1997.
A. F. Hottinger; E. G. Fine; M. E. Gurney; A. D. Zurn; P. Aebischer : The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis; Eur J Neurosci. 1997. DOI : 10.1111/j.1460-9568.1997.tb01511.x.
N. Aebischer; E. Sidorenkova; M. Ravera; G. Laurenczy; D. Osella et al. : Trans- and Cis-Water Reactivities in d6 Octahedral Ruthenium(II) Pentaaqua Complexes: Experimental and Density Functional Theory Studies; Inorganic Chemistry. 1997. DOI : 10.1021/ic970783y.
A. D. Zurn; J. Tseng; P. Aebischer : Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps; Eur Neurol. 1996.
S. A. Tan; N. Deglon; A. D. Zurn; E. E. Baetge; B. Bamber et al. : Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF; Cell Transplant. 1996.
S. A. Tan; P. Aebischer : The problems of delivering neuroactive molecules to the CNS; Ciba Found Symp. 1996.
P. Aebischer; M. Schluep; N. Deglon; J. M. Joseph; L. Hirt et al. : Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients; Nat Med. 1996. DOI : 10.1038/nm0696-696.
E. Buchser; M. Goddard; B. Heyd; J. M. Joseph; J. Favre et al. : Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience; Anesthesiology. 1996. DOI : 10.1097/00000542-199611000-00007.
P. Aebischer; N. A. Pochon; B. Heyd; N. Deglon; J. M. Joseph et al. : Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF; Hum Gene Ther. 1996.
A. D. Zurn; L. Winkel; A. Menoud; K. Djabali; P. Aebischer : Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro; J Neurosci Res. 1996. DOI : 10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E.
N. Deglon; B. Heyd; S. A. Tan; J. M. Joseph; A. D. Zurn et al. : Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts; Hum Gene Ther. 1996.
P. Aebischer; A. C. Kato : Treatment of amyotrophic lateral sclerosis using a gene therapy approach; Eur Neurol. 1995.
J. P. Ranieri; R. Bellamkonda; E. J. Bekos; T. G. Vargo; J. A. Gardella et al. : Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II; J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290614.
R. Bellamkonda; J. P. Ranieri; P. Aebischer : Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro; J Neurosci Res. 1995. DOI : 10.1002/jnr.490410409.
R. Bellamkonda; J. P. Ranieri; N. Bouche; P. Aebischer : Hydrogel-based three-dimensional matrix for neural cells; J Biomed Mater Res. 1995. DOI : 10.1002/jbm.820290514.
P. Aebischer; E. Buchser; J. M. Joseph; J. Favre; N. de Tribolet et al. : Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report; Transplantation. 1994.
J. P. Ranieri; R. Bellamkonda; E. J. Bekos; J. A. Gardella; H. J. Mathieu et al. : Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates; Int J Dev Neurosci. 1994.
A. D. Zurn; E. E. Baetge; J. P. Hammang; S. A. Tan; P. Aebischer : Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones; Neuroreport. 1994. DOI : 10.1097/00001756-199412300-00030.
N. Aebischer; G. Laurenczy; A. Ludi; A. E. Merbach : Monocomplex formation reactions of hexaaquaruthenium(II): a mechanistic study; Inorganic Chemistry. 1993. DOI : 10.1021/ic00065a005.
N. Aebischer : Etude par RMN de réactions de formation de complexes en solution aqueuse de Ru(H2O)6 2+ avec différents ligands S-donneurs ; 1990.
J.-N. Aebischer; M. Amrhein; G. Corminboeuf; S. Crelier; O. Naef et al. : Information extraction from the Evolving Factor Analysis. Swiss Chemical Society – Fall Meeting 2005, Lausanne, Switzerland, October 13, 2005.
P. Voirin; G. Corminboeuf; M. Amrhein; O. Naef; E. Vanoli et al. : Is it possible to get reliable and easy-to-use information from Evolving Factor Analysis?. Swiss Statistics Meeting 2005, Zurich, Switzerland, November 9-11, 2005.
G. Corminboeuf; M. Amrhein; O. Naef; P. Voirin; E. Vanoli et al. : Détermination automatique de fin de réactions à l’aide de méthodes chimiométriques. Chimiométrie 2005, Lille, France, November 30th to December 1st, 2005.

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