Source: https://stanfordhealthcare.org/doctors/w/matthew-wheeler.html
Timestamp: 2019-04-24 18:49:13+00:00

Document:
Bio: I am a physician scientist with interests in cardiomyopathies, rare and undiagnosed diseases, therapeutics and genomics. I have research training in both myocardial and skeletal muscle biology and genetics, genomics, and multi-scale networks. In addition to my research training, I am a physician with interest and experience treating patients with hypertrophic cardiomyopathy and other inherited cardiomyopathies. I have clinical training in medicine, cardiology, cardiovascular genetics, and advanced heart failure. I have extensive translational science efforts, participating in several ongoing clinical trials for hypertrophic cardiomyopathy, dilated cardiomyopathy, ATTR cardiac amyloidosis, and mechanical circulatory support. I am Co-PI of Stanford’s NIH-funded Center for Undiagnosed Diseases a clinical site of the Undiagnosed Diseases Network. I am also a co-Investigator of the Bioinformatics Center of the Molecular Transducers of Physical Activity Consortium. I pursue projects and collaborations at the intersection of striated muscle genetics, genomics, and clinical investigation.
Wheeler, M. T., Snyder, E. C., Patterson, M. N., & Swoap, S. J. (1999). An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 276(5), C1069–C1078.
Zhu, X. L., Hadhazy, M., Groh, M. E., Wheeler, M. T., Wollmann, R., & McNally, E. M. (2001). Overexpression of gamma-sarcoglycan induces severe muscular dystrophy - Implications for the regulation of sarcoglycan assembly. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(24), 21785–21790.
Heydemann, A., Wheeler, M. T., & McNally, E. M. (2001). Cardiomyopathy in animal models of muscular dystrophy. CURRENT OPINION IN CARDIOLOGY, 16(3), 211–217.
Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. Zhu, X., Wheeler, M. T., Hadhazy, M., Lam, M.-Y. J., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB Journal , 16(9), 1096–1098.
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels Chutkow, W. A., Pu, J. L., Wheeler, M. T., Wada, T., Makielski, J. C., Burant, C. F., & McNally, E. M. (2002). Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels. JOURNAL OF CLINICAL INVESTIGATION, 110(2), 203–208.
zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy Wheeler, M. T., Zarnegar, S., & McNally, E. M. (2002). zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. HUMAN MOLECULAR GENETICS, 11(18), 2147–2154.
Cytoskeletal defects in cardiomyopathy McNally, E., Allikian, M., Wheeler, M. T., Mislow, J. M., & Heydemann, A. (2003). Cytoskeletal defects in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(3), 231–241.
The sarcoglycan complex in striated and vascular smooth muscle Wheeler, M. T., Allikian, M. J., Heydemann, A., & McNally, E. M. (2002). The sarcoglycan complex in striated and vascular smooth muscle. Presented at the Cold Spring Harbor Symposium on Quantitative Biology, COLD SPRING HARBOR,NY: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT.
Sarcoglycans in vascular smooth and striated muscle Wheeler, M. T., & McNally, E. M. (2003). Sarcoglycans in vascular smooth and striated muscle. TRENDS IN CARDIOVASCULAR MEDICINE, 13(6), 238–243.
Functional nitric oxide synthase mislocalization in cardiomyopathy Heydemann, A., Huber, J. M., Kakkar, R., Wheeler, M. T., & McNally, E. M. (2004). Functional nitric oxide synthase mislocalization in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 36(2), 213–223.
Secondary coronary artery vasospasm promotes cardiomyopathy progression Wheeler, M. T., Korcarz, C. E., Collins, K. A., Lapidos, K. A., Hack, A. A., Lyons, M. R., … McNally, E. M. (2004). Secondary coronary artery vasospasm promotes cardiomyopathy progression. AMERICAN JOURNAL OF PATHOLOGY, 164(3), 1063–1071.
Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy Wheeler, M. T., Allikian, M. J., Heydemann, A., Hadhazy, M., Zarnegar, S., & McNally, E. M. (2004). Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. JOURNAL OF CLINICAL INVESTIGATION, 113(5), 668–675.
The interaction of coronary tone and cardiac fibrosis. Wheeler, M. T., & McNally, E. M. (2005). The interaction of coronary tone and cardiac fibrosis. Current Atherosclerosis Reports, 7(3), 219–226.
Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise Ashley, E. A., Kardos, A., Jack, E. S., Habenbacher, W., Wheeler, M., Kim, Y. M., … Douglas, P. (2006). Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(3), 523–531.
Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy Le, V.-V., Perez, M. V., Wheeler, M. T., Myers, J., Schnittger, I., & Ashley, E. A. (2009). Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy. AMERICAN HEART JOURNAL, 158(3), E27–E34.
Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes Le, V.-V., Wheeler, M. T., Mandic, S., Dewey, F., Fonda, H., Perez, M., … Froelicher, V. (2010). Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes. CLINICAL JOURNAL OF SPORT MEDICINE, 20(2), 98–105.
Challenges in the clinical application of whole-genome sequencing Ormond, K. E., Wheeler, M. T., Hudgins, L., Klein, T. E., Butte, A. J., Altman, R. B., … Greely, H. T. (2010). Challenges in the clinical application of whole-genome sequencing. LANCET, 375(9727), 1749–1751.
Clinical assessment incorporating a personal genome Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., Dewey, F. E., … Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525–35.
Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels Perez, M. V., Wheeler, M., Ho, M., Pavlovic, A., Wang, P., & Ashley, E. A. (2008). Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(2), 155–165.
Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25–36.
A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy Wheeler, M., Pavlovic, A., deGoma, E., Salisbury, H., Brown, C., & Ashley, E. A. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2(4), 381–391.
Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes Mandic, S., Fonda, H., Dewey, F., Vy-van Le, Stein, R., Wheeler, M., … Froelicher, V. F. (2010). Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes. PHYSICIAN AND SPORTSMEDICINE, 38(2), 156–164.
Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure Dewey, F. E., Perez, M. V., Wheeler, M. T., Watt, C., Spin, J., Langfelder, P., … Ashley, E. A. (2011). Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure. CIRCULATION-CARDIOVASCULAR GENETICS, 4(1), 26–U129.
Systems biology of heart failure, challenges and hopes Dewey, F. E., Wheeler, M. T., & Ashley, E. A. (2011). Systems biology of heart failure, challenges and hopes. CURRENT OPINION IN CARDIOLOGY, 26(4), 314–321.
Interpretation of the Electrocardiogram of Young Athletes Uberoi, A., Stein, R., Perez, M. V., Freeman, J., Wheeler, M., Dewey, F., … Froelicher, V. (2011). Interpretation of the Electrocardiogram of Young Athletes. CIRCULATION, 124(6), 746–757.
DNA Sequencing Clinical Applications of New DNA Sequencing Technologies Dewey, F. E., Pan, S., Wheeler, M. T., Quake, S. R., & Ashley, E. A. (2012). DNA Sequencing Clinical Applications of New DNA Sequencing Technologies. CIRCULATION, 125(7), 931–944.
A public resource facilitating clinical use of genomes Ball, M. P., Thakuria, J. V., Zaranek, A. W., Clegg, T., Rosenbaum, A. M., Wu, X., … Church, G. M. (2012). A public resource facilitating clinical use of genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(30), 11920–27.
Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells Lan, F., Lee, A. S., Liang, P., Sanchez-Freire, V., Nguyen, P. K., Wang, L., … Wu, J. C. (2013). Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. CELL STEM CELL, 12(1), 101–13.
Cardiovascular Magnetic Resonance Imaging Elucidates Genotype-Phenotype Relationships in Patients with Hypertrophic Cardiomyopathy Heidary, S., Wheeler, M. T., Bennett, M. V., Chung, J., Pavlovic, A., Parent, M.-C., … Yang, P. C. (2011). Cardiovascular Magnetic Resonance Imaging Elucidates Genotype-Phenotype Relationships in Patients with Hypertrophic Cardiomyopathy. CIRCULATION, 124(21).
Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy Zhu, X. L., Wheeler, M. T., Hadhazy, M., Lam, M. Y. J., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB JOURNAL, 16(7), 1096-?
Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy Reineck, E., Rolston, B., Bragg-Gresham, J. L., Salberg, L., Baty, L., Kumar, S., … Day, S. M. (2013). Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy. AMERICAN JOURNAL OF CARDIOLOGY, 111(7), 1034–39.
Personalized preventive medicine: genetics and the response to regular exercise in preventive interventions. Bouchard, C., Antunes-Correa, L. M., Ashley, E. A., Franklin, N., Hwang, P. M., Mattsson, C. M., … Wheeler, M. T. (2015). Personalized preventive medicine: genetics and the response to regular exercise in preventive interventions. Progress in Cardiovascular Diseases, 57(4), 337–46.
Outcomes after heart transplantation for amyloid cardiomyopathy in the modern era. Davis, M. K., Kale, P., Liedtke, M., Schrier, S., Arai, S., Wheeler, M., … Witteles, R. M. (2015). Outcomes after heart transplantation for amyloid cardiomyopathy in the modern era. American Journal of Transplantation , 15(3), 650–658.
Limitations of Current AHA Guidelines and Proposal of New Guidelines for the Preparticipation Examination of Athletes Dunn, T. P., Pickham, D., Aggarwal, S., Saini, D., Kumar, N., Wheeler, M. T., … Froelicher, V. F. (2015). Limitations of Current AHA Guidelines and Proposal of New Guidelines for the Preparticipation Examination of Athletes. CLINICAL JOURNAL OF SPORT MEDICINE, 25(6), 472–77.
Examining QRS amplitude criteria for electrocardiographic left ventricular hypertrophy in recommendations for screening criteria in athletes. Singla, V., Jindal, A., Pargaonkar, V., Soofi, M., Wheeler, M., & Froelicher, V. (2015). Examining QRS amplitude criteria for electrocardiographic left ventricular hypertrophy in recommendations for screening criteria in athletes. Journal of Electrocardiology, 48(3), 368–372.
Hypertrophic cardiomyopathy: can the horse be put back in the barn? Wheeler, M. T., & Ashley, E. A. (2015). Hypertrophic cardiomyopathy: can the horse be put back in the barn? Journal of the American College of Cardiology, 65(6), 570–572.
Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy. Bent, R. E., Wheeler, M. T., Hadley, D., Knowles, J. W., Pavlovic, A., Finocchiaro, G., … Perez, M. V. (2015). Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 65(22), 2462–63.
Computerized Q wave dimensions in athletes and hypertrophic cardiomyopathy patients Bent, R. E., Wheeler, M. T., Hadley, D., Froelicher, V., Ashley, E., & Perez, M. V. (2015). Computerized Q wave dimensions in athletes and hypertrophic cardiomyopathy patients. JOURNAL OF ELECTROCARDIOLOGY, 48(3), 362–367.
Gender Differences in Ventricular Remodeling and Function in College Athletes, Insights from Lean Body Mass Scaling and Deformation Imaging Giraldeau, G., Kobayashi, Y., Finocchiaro, G., Wheeler, M., Perez, M., Kuznetsova, T., … Haddad, F. (2015). Gender Differences in Ventricular Remodeling and Function in College Athletes, Insights from Lean Body Mass Scaling and Deformation Imaging. AMERICAN JOURNAL OF CARDIOLOGY, 116(10), 1610–16.
Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure Perez, M. V., Pavlovic, A., Shang, C., Wheeler, M. T., Miller, C. L., Liu, J., … Ashley, E. A. (2015). Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(22), 2522–33.
Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., … Ashley, E. A. (2015). Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLOS GENETICS, 11(10).
Medical implications of technical accuracy in genome sequencing. Goldfeder, R. L., Priest, J. R., Zook, J. M., Grove, M. E., Waggott, D., Wheeler, M. T., … Ashley, E. A. (2016). Medical implications of technical accuracy in genome sequencing. Genome Medicine, 8(1), 24-?
Sports genetics moving forward: lessons learned from medical research. Mattsson, C. M., Wheeler, M. T., Waggott, D., Caleshu, C., & Ashley, E. A. (2016). Sports genetics moving forward: lessons learned from medical research. Physiological Genomics, 48(3), 175–82.
Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Pitsiladis, Y. P., Tanaka, M., Eynon, N., Bouchard, C., North, K. N., Williams, A. G., … Alsayrafi, M. (2016). Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological Genomics, 48(3), 183–90.
in a patient with a complex connective tissue phenotype. Zastrow, D. B., Zornio, P. A., Dries, A., Kohler, J., Fernandez, L., Waggott, D., … Wheeler, M. T. (2017). in a patient with a complex connective tissue phenotype. Cold Spring Harbor Molecular Case Studies, 3(1).
Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device. Banerjee, D., Dutt, D., Duclos, S., Sallam, K., Wheeler, M., & Ha, R. (2017). Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device. World Journal of Cardiology, 9(1), 55–59.
Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy A Randomized Clinical Trial Saberi, S., Wheeler, M., Bragg-Gresham, J., Hornsby, W., Agarwal, P. P., Attili, A., … Day, S. M. (2017). Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 317(13), 1349–57.
Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy. Kobayashi, Y., Wheeler, M., Finocchiaro, G., Ariyama, M., Kobayashi, Y., Perez, M. V., … Haddad, F. (2017). Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy. Echocardiography (Mount Kisco, N.Y.).
The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease Ramoni, R. B., Mulvihill, J. J., Adams, D. R., Allard, P., Ashley, E. A., Bernstein, J. A., … Wise, A. L. (2017). The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 185–92.
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., … Ma, A. (2004). The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. NATURE IMMUNOLOGY, 5(10), 1052–1060.
Long-read genome sequencing identifies causal structural variation in a Mendelian disease. Merker, J. D., Wenger, A. M., Sneddon, T., Grove, M., Zappala, Z., Fresard, L., … Ashley, E. A. (2017). Long-read genome sequencing identifies causal structural variation in a Mendelian disease. Genetics in Medicine : Official Journal of the American College of Medical Genetics.
Accuracy in Wrist-Worn, Sensor-Based Measurements of Heart Rate and Energy Expenditure in a Diverse Cohort. Shcherbina, A., Mattsson, C. M., Waggott, D., Salisbury, H., Christle, J. W., Hastie, T., … Ashley, E. A. (2017). Accuracy in Wrist-Worn, Sensor-Based Measurements of Heart Rate and Energy Expenditure in a Diverse Cohort. Journal of Personalized Medicine, 7(2).
Contractile reserve and cardiopulmonary exercise parameters in patients with dilated cardiomyopathy, the two dimensions of exercise testing. Moneghetti, K. J., Kobayashi, Y., Christle, J. W., Ariyama, M., Vrtovec, B., Kouznetsova, T., … Haddad, F. (2017). Contractile reserve and cardiopulmonary exercise parameters in patients with dilated cardiomyopathy, the two dimensions of exercise testing. Echocardiography (Mount Kisco, N.Y.).
Incremental value of right heart metrics and exercise performance to well-validated risk scores in dilated cardiomyopathy Moneghetti, K. J., Giraldeau, G., Wheeler, M. T., Kobayashi, Y., Vrtovec, B., Boulate, D., … Haddad, F. (2017). Incremental value of right heart metrics and exercise performance to well-validated risk scores in dilated cardiomyopathy . European Heart Journal - Cardiovascular Imaging .
Functional Cardiac Recovery and Hematologic Response to Chemotherapy in Patients With Light-Chain Amyloidosis (from the Stanford University Amyloidosis Registry). Tuzovic, M., Kobayashi, Y., Wheeler, M., Barrett, C., Liedtke, M., Lafayette, R., … Witteles, R. (2017). Functional Cardiac Recovery and Hematologic Response to Chemotherapy in Patients With Light-Chain Amyloidosis (from the Stanford University Amyloidosis Registry). The American Journal of Cardiology, 120(8), 1381–86.
A New Approach to Rare Diseases of Children: The Undiagnosed Diseases Network. Reuter, C. M., Brimble, E., DeFilippo, C., Dries, A. M., Enns, G. M., Ashley, E. A., … Wheeler, M. T. (2018). A New Approach to Rare Diseases of Children: The Undiagnosed Diseases Network. The Journal of Pediatrics.
Athletic Remodeling in Female College Athletes, the "Morganroth Hypothesis" Revisited. Kooreman, Z., Giraldeau, G., Finocchiaro, G., Kobayashi, Y., Wheeler, M., Perez, M., … Haddad, F. (2018). Athletic Remodeling in Female College Athletes, the "Morganroth Hypothesis" Revisited. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine.
Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Li, X., Kuznetsova, T., Cauwenberghs, N., Wheeler, M., Maecker, H., Wu, J. C., … Dai, H. (2017). Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7089–94.
Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder Olahova, M., Yoon, W. H., Thompson, K., Jangam, S., Fernandez, L., Davidson, J. M., … Wheeler, M. T. (2018). Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. AMERICAN JOURNAL OF HUMAN GENETICS, 102(3), 494–504.
Genetic Variation Near HCRTR2 Associates With Dramatic Improvement of Heart Function in Patients With Heart Failure Perez, M. V., Pavlovic, A., Wheeler, M. T., Miller, C. L., Thanaporn, P., Dewey, F. E., … Ashley, E. (2013). Genetic Variation Near HCRTR2 Associates With Dramatic Improvement of Heart Function in Patients With Heart Failure. CIRCULATION, 128(22).
Large Q and S waves in lead III on the electrocardiogram distinguish patients with hypertrophic cardiomyopathy from athletes. Chen, A. S., Bent, R. E., Wheeler, M., Knowles, J. W., Haddad, F., Froelicher, V., … Perez, M. V. (2018). Large Q and S waves in lead III on the electrocardiogram distinguish patients with hypertrophic cardiomyopathy from athletes. Heart (British Cardiac Society).
Applying current normative data to prognosis in heart failure: The Fitness Registry and the Importance of Exercise National Database (FRIEND) Moneghetti, K. J., Hock, J., Kaminsky, L., Arena, R., Lui, G. K., Haddad, F., … Christle, J. W. (2018). Applying current normative data to prognosis in heart failure: The Fitness Registry and the Importance of Exercise National Database (FRIEND). INTERNATIONAL JOURNAL OF CARDIOLOGY, 263, 75–79.
Genome Sequencing in HypertrophicCardiomyopathy. Ashley, E. A., Reuter, C. M., & Wheeler, M. T. (2018). Genome Sequencing in HypertrophicCardiomyopathy. Journal of the American College of Cardiology, 72(4), 430–33.
Time based versus strain based myocardial performance indices in hypertrophic cardiomyopathy, the merging role of left atrial strain. Kobayashi, Y., Moneghetti, K. J., Bouajila, S., Stolfo, D., Finocchiaro, G., Kuznetsova, T., … Haddad, F. (2018). Time based versus strain based myocardial performance indices in hypertrophic cardiomyopathy, the merging role of left atrial strain. European Heart Journal Cardiovascular Imaging.
Electrocardiographic left atrial abnormalities predict cardiovascular mortality Ha, L. D., Grober, A. F., Hock, J., Wheeler, M., Elbadawi, A., Biniwale, N., … Froelicher, V. (2018). Electrocardiographic left atrial abnormalities predict cardiovascular mortality. JOURNAL OF ELECTROCARDIOLOGY, 51(4), 652–57.
Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. Maurer, M. S., Schwartz, J. H., Gundapaneni, B., Elliott, P. M., Merlini, G., Waddington-Cruz, M., … Rapezzi, C. (2018). Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. The New England Journal of Medicine.
Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. Splinter, K., Adams, D. R., Bacino, C. A., Bellen, H. J., Bernstein, J. A., Cheatle-Jarvela, A. M., … Ashley, E. A. (2018). Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. The New England Journal of Medicine.
Evolving Decisions: Perspectives of Active and Athletic Individuals with Inherited Heart Disease Who Exercise Against Recommendations. Subas, T., Luiten, R., Hanson-Kahn, A., Wheeler, M., & Caleshu, C. (2018). Evolving Decisions: Perspectives of Active and Athletic Individuals with Inherited Heart Disease Who Exercise Against Recommendations. Journal of Genetic Counseling.
BEST IN PHYSICS (THERAPY) - Stereotactic Radiotherapy for Renal Sympathetic Ablation for the Treatment of Refractory Hypertension Maxim, P., Wheeler, M., Maguire, P., & Loo, B. (2014). BEST IN PHYSICS (THERAPY) - Stereotactic Radiotherapy for Renal Sympathetic Ablation for the Treatment of Refractory Hypertension. MEDICAL PHYSICS, 41(6), 503–4.
Exercise for Patients With Hypertrophic Cardiomyopathy Reply Saberi, S., Wheeler, M., & Day, S. M. (2017). Exercise for Patients With Hypertrophic Cardiomyopathy Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 318(5), 481–82.
Repeats and Survival in Myotonic Dystrophy Type 1 Wheeler, M. T. (2017). Repeats and Survival in Myotonic Dystrophy Type 1. CIRCULATION-CARDIOVASCULAR GENETICS, 10(3).
Exercise restrictions trigger psychological difficulty in active and athletic adults with hypertrophic cardiomyopathy Luiten, R. C., Ormond, K., Post, L., Asif, I. M., Wheeler, M. T., & Caleshu, C. (2016). Exercise restrictions trigger psychological difficulty in active and athletic adults with hypertrophic cardiomyopathy. OPEN HEART, 3(2).
Letter by Wheeler et al Regarding Article, "Recognition and Significance of Pathological T-Wave Inversions in Athletes" Wheeler, M. T., Adelfattah, R., & Froelicher, V. F. (2015). Letter by Wheeler et al Regarding Article, "Recognition and Significance of Pathological T-Wave Inversions in Athletes". CIRCULATION, 132(14), E180.
Extremely elevated lipoprotein(a), combined hyperlipidemia, and premature atherosclerosis in a Chinese family deGoma, E. M., Wheeler, M. T., Marcovina, S. M., & Ashley, E. A. (2010). Extremely elevated lipoprotein(a), combined hyperlipidemia, and premature atherosclerosis in a Chinese family. JOURNAL OF CLINICAL LIPIDOLOGY, 4(6), 543–47.
Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources. Kohler, S., Carmody, L., Vasilevsky, N., Jacobsen, J. O., Danis, D., Gourdine, J.-P., … Robinson, P. N. (2018). Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources. Nucleic Acids Research.
ClinPhen extracts and prioritizes patient phenotypes directly from medical records to expedite genetic disease diagnosis. Deisseroth, C. A., Birgmeier, J., Bodle, E. E., Kohler, J. N., Matalon, D. R., Nazarenko, Y., … Bejerano, G. (2018). ClinPhen extracts and prioritizes patient phenotypes directly from medical records to expedite genetic disease diagnosis. Genetics in Medicine : Official Journal of the American College of Medical Genetics.
The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation. Aymami, M., Amsallem, M., Adams, J., Sallam, K., Moneghetti, K., Wheeler, M., … Banerjee, D. (2018). The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation. Journal of Cardiac Failure, 24(12), 823–32.
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Seeger, T., Shrestha, R., Lam, C. K., Chen, C., McKeithan, W. L., Lau, E., … Wu, J. C. (2018). A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation.
Developing a genomics rotation: Practical training around variant interpretation for genetic counseling students. Grove, M. E., White, S., Fisk, D. G., Rego, S., Dagan-Rosenfeld, O., Kohler, J. N., … Hanson-Kahn, A. K. (2019). Developing a genomics rotation: Practical training around variant interpretation for genetic counseling students. Journal of Genetic Counseling.
A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis. Hom, J., Marwaha, S., Postolova, A., Kittle, J., Vasquez, R., Davidson, J., … Wheeler, M. (2019). A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis. Journal of General Internal Medicine.
Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Parikh, V. N., Caleshu, C., Reuter, C., Lazzeroni, L. C., Ingles, J., Garcia, J., … Ashley, E. (2019). Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Circulation. Heart Failure, 12(3), e005371.
A toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing. Zastrow, D. B., Kohler, J. N., Bonner, D., Reuter, C. M., Fernandez, L., Grove, M. E., … Wheeler, M. T. (2019). A toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing. Journal of Genetic Counseling, 28(2), 213–28.
Dr. Wheeler always excellent. Julia Platt - genetics consultant also very good.
Everyone was so professional but in a relaxed and friendly way.
Dr. Matthew Wheeler ALWAYS takes the time to help us understand where I am at in my process and LISTENS to what I am needing to tell him about such a big decision. My confidence in him and Stanford is so very high. I am grateful.
They listened & observed the pain but no solutions they measured the # of low flows but offered no new information - why were we there?
Dr. Wheeler is excellent in all ways.
Great follow up - Thank you.
Quiet voice. I had to ask him to speak louder several times. Very professional and caring.
After the visit when I forgot the instructions the care provider wasn't as clear or patient. But that's understandable b/c it was their time.
Great first visit with Dr. Wheeler took plenty of time to review details with me.
Dr. Wheeler is a very competent physician and spent all the time needed to inform me of my available choices.
Always very detailed - spends quality time.
We are impressed with the quality and quantity of time we've had with each doctor and supporting staff. It's something we talk about with our friends and family. I feel like I'm in the best possible hands in the world.

References: V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V. 
 V.