Source: http://niikelsoramn.ru/institut/podrazdelenija/gruppa-experiment-farmakologii/group-experimental-pharmacology/
Timestamp: 2019-04-18 20:29:23+00:00

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The research interests of collective are concentrated in the area of modern lymphology, which includes three components as the object of its investigation: lymphatic (drainage, vascular) system, lymphoid (immune) system with its central and periphery branches and system of loose connective tissue (interstice). All these components in their interaction create a unified protective system (Member of the Russian Academy of Science V.I. Konenkov), which morphofunctional unit is lymphatic region, which include carrier and detoxicative components (Member of the Russian Academy of Science Yu. I. Borodin).
The head of experimental pharmacology group – principal researcher, PhD, Professor Svetlana V. Michurina. She is a member of the Scientific Council of the Interregional Scientific-Advisory center of the endoecological rehabilitation, Russian society of lymphologists, Siberian society of lymphologists, Society of anatomists, histologists and embryologists. The author of more than 320 works, including three monographs, 5 patents. Under the auspices of Michurina eight theses, including one doctoral thesis and seven PhD have been prepared and defended.
For her productive work, she was awarded an honorary certificate of the Presidium of the Russian Academy of Medical Science, of the Presidium of the Russian Academy of Medical Science Siberian branch, of the governor of the Novosibirsk region, medal and certificate of Rudolf Virchow (European Academy of Natural Science, Germany, Hanover). She completed internal and external training in the rules of preclinical investigation in accordance with GLP standards on the base of the center for genetic resources of laboratory animals of the Federal Research Center Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Medical Science.
- scientific rationale and engineering support of the rational medical practice and evidence-based medicine from the perspective of lymphatic prevention, correction and protection.
- «study of molecular mechanisms, detection of genomic and postgenomic markers, development of new approach to correction pathological remodeling of blood, lymphatic vessels and connective tissue in case of endocrine pathology» (0539-2014-0011) (head PhD Klimontov V.V.) reg №115091850008.
- realization of biomedical trial and valuation of biological acceptability of chemical and biological substance, stuff, materials and equipment of the medical, manufacturing and domestic use.
Hepatology, Rheumatology, Endocrinology, Oncology, Neuropathology, Neuro-immune-endocrine relation and other.
Light microscopy, fluorescein microscopy, electronic microscopy, histochemical methods, immunohistochemical methods, quantitative valuation of molecular particularities of liver and lymphatic nodes, methods of morphometric analysis of the micro- and ultrastructural peculiarities of the lymphatic regions of organs.
Experiments are realizing on the base of Common use center “SPF-vivarium” Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Medical Science.
Experimental animals: homozygous mice db/db line BKS.Cg-Dock7m+/+Leprdb/J with model of obesity and diabetes mellitus type 2, SPF mice С57Bl/6J, rats Wistar and other.
Within a realization of trials of new medicaments group of “Experimental farmacology” initiator and, шт cooperation with Common use center “SPF-vivarium” Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Medical Science, creator of the cluster “Farmakon”, which connects efforts of high-grade specialists in area of microscopy and work with laboratory animals. Aim of cluster “Farmakon” is supporting realization of wide-ranging scientific investigations in the area of actual medicine for deciphering of mecanisms of action of the biologically active substance and creation original domestic medicaments with hemorrheological, lymphotropic, anxiolytic, antidepressant, nootropic and antihypoxic activity for its using in personalized treatment and prevention of socially important diseases. These investigations are realizing with use of modern high-technology laboratory animals - models of human pathology.
Neuro-vegetative reaction of animals caused by medicaments.
Were identified peculiarities of the daily time organization of the liver and its lymphatic region in condition of the disturbance of the light regime, which leads to disturbance of melatonin synthesis (functional epiphysectomia of the melatonin-producing function of the epiphysis) and the development of desynchronosis. Were determined the possibility of correction of disturbed circadian biorhythms of the lymphatic region of the liver and organs of the reproductive system with use of melatonin (Patent No. 2418586).
Were studied interrelation between the lymphatic region of the liver and regulatory and metabolic systems (lymphatic, immune, endocrine).
Scientific interests: histology, cytology, cell biology, molecular and cellular medicine, immunomorphology, general and medical immunology, pathomorphology, chronic inflammation, type 2 diabetes, experimental oncology, hepatology, lymphology, pharmacology, embryology, ontogeny, imprinting, biorhythmology, toxicology, reproductive system, lymphatic region of the liver, apoptosis, cellular receptors, immunocytochemistry, cell activation and differentiation, lymphatic and blood vessels, lymphatic nodes, ecology (influence of toxicants - benz(a)pyrene, CCl4, power frequency magnetic field, alcohol, day-night lighting, etc.), melatonin correction, natural and artificial sorbents, bioflavonoids and other.
Area of ​​scientific interests: histology, cytology, cell biology, immunology, immunomorphology, lymphology, hepatology, molecular and cellular medicine, experimental oncology. She completed internal and external training in rules of preclinical investigation in accordance with GLP standards on the base of center for genetic resources of laboratory animals of the Federal Research Center Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Medical Science. Ishchenko I.Yu. She has skills of methods of light and electronic microscopy, morphometric methods (liver, thymus) stereometric analysis of lymph nodes, has mastered methodological approaches to quantitative analysis of immunohistochemical preparations. The author of more than 90 works, incl. chapters in two monographs, 1 patent. Currently, Irina Y. works on his doctoral dissertation.
Scientific interests: histology, cytology, cell biology, immunology, immunomorphology, experimental oncology, cell biology, molecular and cellular medicine, general and medical immunology, immunohistochemistry, immunocytochemistry, chronic inflammation, cell activation and differentiation, apoptosis, cellular receptors, cytokines, growth factors, nanotechnology. Author of more than 300 scientific works, incl. 3 monographs, 14 patents for inventions. Under the auspices of Archipov 3 Ph.D. theses have been prepared and defended.
Area of scientific interests: histology, cytology, cell biology, immunology, immunomorphology, molecular and cellular medicine, endocrinology.
She has skills of methods of histological technique, light and electronic microscopy. She completed internal and external training in rules of preclinical investigation in accordance with GLP standards on the base of center for genetic resources of laboratory animals of the Federal Research Center Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Medical Science.
She has skills of methods of histological technique, light microscopy.
S. V. Michurina ; I. Yu. Ishchenko ; M. A. Cherepanova ; S. A. Arkhipov ; Yu. I. Borodin ; E.L. Zavjalov, D.V. Vasendin. Apoptosis in the liver of db/db Mice Female in Postnatal Ontogenesis. 2018 11th International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology (BGRSSB) 20-25 Aug. 2018.-Publication Year: 2018, Page(s):5 – 9.
Yuriy I. Borodin ; Lybov N. Rachkovskaya ; Tatyana. V. Popova ;Anastasiya A.Kotlyarova ; Svetlana V. Michurina ; Anna V. Shurlygina ; Edmund E.Rachkovskiy ; Margarita V. Robinson ;Pavel G. Madonov ; Maxim A. Korolev ; Andrey Yu.Letyagin ;Vladimir I. Konenkov.Modified Sorbents for Pharmacology. 2018 11th International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology (BGRSSB),20-25 Aug. 2018.-Publication Year: 2018, Page(s):47 – 50.
Borodin Yu.I., Rachkovskaya L.N., Popova T.V., Kotlyarova A.A., Michurina S.V., Shurlygina A.V., Rachkovsky E.E., Robinson M.V., Madonov P.G., Korolev M.A., Letyagin A.Yu., Konenkov V.I. Modified sorbents for pharmacology. // Systems Biology and Biomedicine (SBioMed-2018): Symposium (21-22 Aug. 2018, Novosibirsk,Russia).- Novosibirsk: ICG SB RAS, 2018.- c.29.
Michurina S.V., Ishchenko I.Yu., Cherepanova M.A., Arkhipov S.A., Klimontov V.V., Zavyalov E.L. Linagliptin effect on expression of apoptosis regulators Bcl-2 and Bad in db/db mice liver. // Systems Biology and Biomedicine (SBioMed-2018): Symposium (21-22 Aug. 2018, Novosibirsk, Russia).- Novosibirsk: ICG SB RAS, 2018.- c.90.
Michurina S.V., Ishchenko I.Yu., Cherepanova M.A., Arkhipov S.A., Zavyalov E.L. Apoptosis in the liver of db/db mice female in postnatal ontogenesis. // Systems Biology and Biomedicine (SBioMed-2018): Symposium (21-22 Aug. 2018, Novosibirsk,Russia).- Novosibirsk: ICG SB RAS, 2018.- c.91.
S. V. Michurina ; I. Yu. Ishchenko ; M. A. Cherepanova ; S. A. Arkhipov ; Yu. I. Borodin ; E.L. Zavjalov ; D.V. Vasendin Apoptosis in the liver of db/db Mice Female in Postnatal Ontogenesis. 2018 11th International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology (BGRSSB)20-25 Aug. 2018. EEE Xplore Digital Librar. Publication Year: 2018, Page(s):5 – 9.
Yuriy I. Borodin ; Lybov N. Rachkovskaya ; Tatyana. V. Popova ;Anastasiya A. Kotlyarova ; Svetlana V. Michurina ; Anna V. Shurlygina ; Edmund E. Rachkovskiy ; Margarita V. Robinson ;Pavel G. Madonov ; Maxim A. Korolev ; Andrey Yu. Letyagin ;Vladimir I. Konenkov. Modified Sorbents for Pharmacology Xplore Digital Librar.Publication Year: 2018, Page(s):47 – 50.

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