Source: https://www.bumc.bu.edu/busm/profile/maria-cardamone/
Timestamp: 2019-04-18 23:23:03+00:00

Document:
I’m currently a Research Assistant Professor in Dr. Valentina Perissi’s Laboratory at Boston University School of Medicine. I hold a “Laurea” in Molecular Biology (equivalent to a B.S. and a Master) and a PhD in Complex System in Molecular Biology from the University of Turin in Italy. As part of my doctoral fellowship, I spend the last two years of my doctorate in Dr. Rosenfeld Laboratory in La Jolla as a Visiting Graduate Student to investigate breast cancer from an epigenetic standpoint. After graduation I become a junior postoctoral fellow in Dr. Rosenfeld Lab. and after three years of training I join Dr. Perissi Lab. as a senior postdoctoral fellow.
In my work as a PhD student I focused on the diverse aspects of the action of estrogen receptor alpha (ERa) in the regulation of gene expression and chromatin architecture in breast cancer. My studies help to establish that estrogen causes an ERa dependent series of interchromosomal interaction, linking transcriptional interactions, elongation and RNA processing event. Also I was able to describe a new role for ERa as a ligand-independent activator that can be essential for the determination of epithelial morphology and epithelial-mesenchymal transition (EMT) during breast cancer progression. In my most recent research I have focused on investigating the role of the nuclear receptor cofactor G Protein Suppressor 2 (GPS2), in regulating non-proteolytic ubiquitin signaling events both inside and outside of the nucleus. Thanks to this work, GPS2 has emerged as a novel and critical regulator of lipid metabolism and inflammation in the adipose tissue.
Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141). PMID: 30531713.
Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7. PMID: 29499132.
Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138. PMID: 28539390.
Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772. PMID: 28039360.
Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137. PMID: 28123943.
Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54. PMID: 26070566.
Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?. Cell Rep. 2014 Jul 10; 8(1):163-76. PMID: 24953653.
Cardamone MD, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass CK, Rosenfeld MG, Perissi V. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13; 46(1):91-104. PMID: 22424771.
Cardamone MD, Bardella C, Gutierrez A, Di Croce L, Rosenfeld MG, Di Renzo MF, De Bortoli M. ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7420-5. PMID: 19383788.
Hu Q, Kwon YS, Nunez E, Cardamone MD, Hutt KR, Ohgi KA, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG, Fu XD. Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19199-204. PMID: 19052240.

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