Source: https://www.bio-rad-antibodies.com/monoclonal/mouse-art2-2-antibody-nika102-mca1975.html
Timestamp: 2019-04-19 20:48:14+00:00

Document:
Staining of C57Bl/6J mouse spleen cells with Rat anti Mouse ART2.2 antibody (MCA1975).
Rat anti Mouse ART2.2 antibody, clone Nika102 recognizes the gene product of the mouse ADP-ribosyltransferase (ART) 2.2 gene, an ortholog of rat RT6. ART2.2 expressed exclusively by mature T-cells. Levels of ART2.2 expression vary between inbred strains of mice and is absent in NZW mice, in which the ART2.2 gene is deleted (Koch-Nolte et al. 1999).
Spleen cells from immunized wistar rats were fused with cells of the Sp2/0 mouse myeloma cell line.
Koch-Nolte, F. et al. (1999) A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation.
J Immunol. 163 (11): 6014-22.
Adriouch, S. et al. (2001) Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector.
Kahl, S. et al. (2000) Metalloprotease-mediated shedding of enzymatically active mouse ecto-ADP-ribosyltransferase ART2.2 upon T cell activation.
Ablamunits, V. et al. (2001) Changing patterns of cell surface mono (ADP-ribosyl) transferase antigen ART2.2 on resting versus cytopathically-activated T cells in NOD/Lt mice.
Adriouch, S. et al. (2007) NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo.
J Immunol. 179 (1): 186-94.
Menzel, S. et al. (2015) Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.
J Immunol. 195 (5): 2057-66.
Heiss K et al. (2008) High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.
J Immunol. 181 (6): 3861-9.

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