Source: http://inct-bionat.iq.unesp.br/en/participantes/pesquisadores/maria-jose-soares-mendes-giannini/
Timestamp: 2019-04-19 19:00:37+00:00

Document:
Exploração funcional e diagnóstica de biomoléculas e xenobióticos e interação fungo-hospedeiro.
Estudo de atividade antifúngica a partir de fontes naturais e sintéticas, investigando alvos através de determinações genômicas e proteômicas e por meios de bancos celulares complementando o processo de desenvolvimento de moléculas importantes para obtenção de pró-fármacos, bem como sua eficácia e segurança por métodos alternativos.
Estudo dos aspectos básicos das diferentes doenças fungicas com ênfase nos aspectos celulares, moleculares e/ou fisiopatológicos.
Medina-Alarcón KP, Voltan AR, Fonseca-Santos B, Moro IJ, de Oliveira Souza F, Chorilli M, Soares CP, Dos Santos AG, Mendes-Giannini MJS, Fusco-Almeida AM. Highlights in nanocarriers for the treatment against cervical cancer. Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:748-759. doi: 10.1016/j.msec.2017.07.021. Review.
Silva-Rocha WP, de Azevedo MF, Ferreira MRA, da Silva JF, Svidzinski TIE, Milan EP, Soares LAL, Rocha KBF, Uchôa AF, Mendes-Giannini MJS, Fusco Almeida AM, Chaves GM. Effect of the Ethyl Acetate Fraction of Eugenia uniflora on Proteins Global Expression during Morphogenesis in Candida albicans. Front Microbiol. 2017 Sep 26;8:1788. doi: 10.3389/fmicb.2017.01788.
Mordorski B, Costa-Orlandi CB, Baltazar LM, Carreño LJ, Landriscina A, Rosen J, Navati M, Mendes-Giannini MJS, Friedman JM, Nosanchuk JD, Friedman AJ. Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis. Nanomedicine. 2017 Oct;13(7):2267-2270. doi: 10.1016/j.nano.2017.06.018.
Voltan AR, Alarcon KM, Fusco-Almeida AM, Soares CP, Mendes-Giannini MJS, Chorilli M. Highlights in Endocytosis of Nanostructured Systems. Curr Med Chem. 2017;24(18):1909-1929. doi: 10.2174/0929867324666170214111205. Review.
Singulani JL, Scorzoni L, Gomes PC, Nazaré AC, Polaquini CR, Regasini LO, Fusco-Almeida AM, Mendes-Giannini MJS. Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models. Future Med Chem. 2017 Oct;9(16):1863-1872. doi: 10.4155/fmc-2017-0096.
Scorzoni L, de Paula E Silva ACA, de Oliveira HC, Marcos CM, Singulani JL, Fusco-Almeida AM, Mendes-Giannini MJS. Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model? Med Mycol. 2017 Jun 15. doi: 10.1093/mmy/myx045.
Medina-Alarcón KP, Singulani JL, Voltan AR, Sardi JCO, Petrônio MS, Santos MB, Polaquini CR, Regasini LO, Bolzani VS, da Silva DHS, Chorilli M, Mendes-Giannini MJS, Fusco-Almeida AM. Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for Paracoccidioides brasiliensis and Paracoccidioides lutzii In Vitro. Front Microbiol. 2017 Jun 12;8:1048. doi: 10.3389/fmicb.2017.01048. eCollection 2017.
Bernardi T, da Silva JF, Vicentin J, de Oliveira HC, Assato PA, Marcos CM, de Paula E Silva ACA, da Silva RAM, Regasini LO, Silva DHS, da Silva Bolzani V, Fusco-Almeida AM, Mendes-Giannini MJS. Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43. Med Mycol. 2017 Nov 1;55(8):890-894. doi: 10.1093/mmy/myx013.
Voltan AR, Quindós G, Alarcón KP, Fusco-Almeida AM, Mendes-Giannini MJ, Chorilli M. Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy? Int J Nanomedicine. 2016 Aug 8;11:3715-30. doi: 10.2147/IJN.S93105. eCollection 2016. Review.
Rossi SA, Trevijano-Contador N, Scorzoni L, Mesa-Arango AC, de Oliveira HC, Werther K, de Freitas Raso T, Mendes-Giannini MJ, Zaragoza O, Fusco-Almeida AM. Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates. Front Microbiol. 2016 Feb 16;7:153. doi: 10.3389/fmicb.2016.00153.
Scorzoni L, Sangalli-Leite F, de Lacorte Singulani J, de Paula E Silva AC, Costa-Orlandi CB, Fusco-Almeida AM, Mendes-Giannini MJ. Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds. J Microbiol Methods. 2016 Apr;123:68-78. doi: 10.1016/j.mimet.2016.02.005. Epub 2016 Feb 4. Review.
Martins CHG, Pires RH, Cunha AO, Pereira CAM, Singulani JL, Abrão F, Moraes T, Mendes-Giannini MJS. Candida/Candida biofilms. First description of dual-species Candida albicans/C. rugosa biofilm. Fungal Biol. 2016 Apr;120(4):530-537. doi: 10.1016/j.funbio.2016.01.013.
Benaducci T, Sardi Jde C, Lourencetti NM, Scorzoni L, Gullo FP, Rossi SA, Derissi JB, de Azevedo Prata MC, Fusco-Almeida AM, Mendes-Giannini MJ. Virulence of Cryptococcus sp. Biofilms In Vitro and In Vivo using Galleria mellonella as an Alternative Model. Front Microbiol. 2016 Mar 9;7:290. doi: 10.3389/fmicb.2016.00290. eCollection 2016.
Souza CM, Pereira Junior SA, Moraes Tda S, Damasceno JL, Amorim Mendes S, Dias HJ, Stefani R, Tavares DC, Martins CH, Crotti AE, Mendes-Giannini MJ, Pires RH. Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells. Med Mycol. 2016 Jul 1;54(5):515-23. doi: 10.1093/mmy/myw003.
de Lacorte Singulani J, Scorzoni L, de Paula E Silva AC, Fusco-Almeida AM, Mendes-Giannini MJ. Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model. Int J Antimicrob Agents. 2016 Sep;48(3):292-7. doi: 10.1016/j.ijantimicag.2016.05.012.
Sardi JC, Gullo FP, Freires IA, Pitangui NS, Segalla MP, Fusco-Almeida AM, Rosalen PL, Regasini LO, Mendes-Giannini MJ. Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. Diagn Microbiol Infect Dis. 2016 Dec;86(4):387-391.
Scorzoni L, de Paula e Silva AC, Singulani Jde L, Leite FS, de Oliveira HC, da Silva RA, Fusco-Almeida AM, Mendes-Giannini MJ. Comparison of virulence between Paracoccidioides brasiliensis and Paracoccidioides lutzii using Galleria mellonella as a host model. Virulence. 2015;6(8):766-76. doi: 10.1080/21505594.2015.1085277.
Sardi Jde C, Pitangui Nde S, Voltan AR, Braz JD, Machado MP, Fusco Almeida AM, Mendes Giannini MJ. In vitro Paracoccidioides brasiliensis biofilm and gene expression of adhesins and hydrolytic enzymes. Virulence. 2015;6(6):642-51. doi: 10.1080/21505594.2015.1031437. Erratum in: Virulence. 2015;6(7):726.
MELO, WANESSA C.M.A. ; SANTOS, MARIANA BASTOS DOS ; MARQUES, BEATRIZ DE CARVALHO ; REGASINI, LUIS OCTÁVIO ; GIANNINI, MARIA JOSÉ SOARES MENDES ; ALMEIDA, ANA MARISA FUSCO . Selective photoinactivation of Histoplasma capsulatum by water-soluble derivatives chalcones. Photodiagnosis and Photodynamic Therapy, v. x, p. x-x, 2017.
SCORZONI, LILIANA ; de Paula e Silva, Ana C. A. ; MARCOS, CAROLINE M. ; ASSATO, PATRÍCIA A. ; DE MELO, WANESSA C. M. A. ; DE OLIVEIRA, HAROLDO C. ; COSTA-ORLANDI, CAROLINE B. ; MENDES-GIANNINI, MARIA J. S. ; FUSCO-ALMEIDA, ANA M. . Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis. Frontiers in Microbiology, v. 08, p. 1-23, 2017.
COSTA-ORLANDI, CAROLINE ; SARDI, JANAINA ; PITANGUI, NAYLA ; DE OLIVEIRA, HAROLDO ; SCORZONI, LILIANA ; GALEANE, MARIANA ; MEDINA-ALARCÓN, KAILA ; MELO, WANESSA ; MARCELINO, MÔNICA ; BRAZ, JAQUELINE ; FUSCO-ALMEIDA, ANA ; MENDES-GIANNINI, MARIA . Fungal Biofilms and Polymicrobial Diseases. Journal of Fungi, v. 3, p. 22, 2017.
PALANCO, ANA CERREJÓN ; LACORTE SINGULANI, JUNYA DE ; COSTA-ORLANDI, CAROLINE BARCELOS ; GULLO, FERNANDA PATRÍCIA ; STROHMAYER LOURENCETTI, NATÁLIA MANUELA ; GOMES, PAULO CÉSAR ; AYUSSO, GABRIELA MIRANDA ; DUTRA, LUIZ ANTÔNIO ; SILVA BOLZANI, VANDERLAN DA ; REGASINI, LUIS OCTÁVIO ; SOARES MENDES-GIANNINI, MARIA JOSÉ ; Fusco-Almeida, Ana Marisa . Activity of 3–hydroxychalcone against and toxicity, and efficacy in alternative animal models. Future Microbiology, v. 12, p. fmb-2017-0062, 2017.
SOUZA, BARBARA ; GUARALDO, THAIS ; BRUGNERA, MICHELLE ; PIRES, REGINA ; GIANNINI, MARIA ; ZANONI, MARIA . Antifungal Properties of High Efficient W/WO3 Electrodes Acting under UV-Vis and Visible Light and Chloride Medium. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 28, p. 2084-2093, 2017.
Rossi, Suélen A. ; TREVIJANO-CONTADOR, NURIA ; SCORZONI, LILIANA ; MESA-ARANGO, ANA CECILIA ; DE OLIVEIRA, HAROLDO C. ; WERTHER, KARIN ; DE FREITAS RASO, TÂNIA ; MENDES-GIANNINI, MARIA J. S. ; ZARAGOZA, OSCAR ; FUSCO-ALMEIDA, ANA M. . Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates. Frontiers in Microbiology (Online), v. 7, p. 153, 2016.
SOUZA, C.M. ; PEREIRA-JUNIOR, S.A. ; MORAES, T.D. ; DAMASCENO, J.L. ; AMORIM MENDES, S. ; DIAS, H.J. ; STEFANI, R. ; TAVARES, D.C. ; MARTINS, C.H. ; CROTTI, A.E. ; MENDES-GIANNINI, M.J.S. ; PIRES, R.H. . Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells. Medical Mycology (Oxford. Online), v. 54, p. 515-523, 2016.
DA SILVA, JULHIANY DE FÁTIMA ; DE OLIVEIRA, HAROLDO CESAR ; MARCOS, CAROLINE MARIA ; ASSATO, PATRICIA AKEMI ; Fusco-Almeida, Ana Marisa ; MENDES-GIANNINI, MARIA JOSÉ SOARES . Advances and challenges in paracoccidioidomycosis serology caused by Paracoccidioides species complex: an update. Diagnostic Microbiology and Infectious Disease, v. 84, p. 87-94, 2016.
LIMA, CAROLINE SPRENGEL ; POLAQUINI, CARLOS ROBERTO ; SANTOS, MARIANA BASTOS DOS ; GULLO, FERNANDA PATRÍCIA ; LEITE, FERNANDA SANGALLI ; SCORZONI, LILIANE ; BOLZANI, VANDERLAN DA SILVA ; MENDES-GIANNINI, MARIA JOSÉ SOARES ; Fusco-Almeida, Ana Marisa ; REZENDE, ANDRÉIA ALVES ; REGASINI, LUIS OCTAVIO . Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from Pterogyne nitens. Asian Pacific Journal of Tropical Biomedicine, v. 6, p. 841-845, 2016.
DE LACORTE SINGULANI, JUNYA ; SCORZONI, LILIANA ; DE PAULA E SILVA, ANA CAROLINA ALVES ; Fusco-Almeida, Ana Marisa ; MENDES-GIANNINI, MARIA JOSÉ SOARES . Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model. International Journal of Antimicrobial Agents (Print), v. 48, p. 292-297, 2016.
SOARES LA, GULLO FP, SARDI JDE C, PITANGUI NDE S, COSTA-ORLANDI CB, SANGALLI-LEITE F, SCORZONI L, REGASINI LO, PETRÔNIO MS, SOUZA PF, SILVA DH, MENDES-GIANNINI MJ, FUSCOALMEIDA AM. Anti-trichophyton activity of protocatechuates and their synergism with fluconazole. Evid Based Complement Alternat Med. 2014.
BATISTA VG, TOLEDO MS, STRAUS AH, MENDES-GIANNINI MJ, DUARTE AJ, TAKAHASHI HK, BENARD G. Glycolipid sensing and innate immunity in paracoccidioidomycosis. Mycopathologia, v.178, p.153-62, 2014.
COSTA-ORLANDI CB, SARDI JC, SANTOS CT, FUSCO-ALMEIDA AM, MENDES-GIANNINI MJ. In vitro characterization of Trichophyton rubrum and T. mentagrophytes biofilms. Biofouling, v.30, p.719- 27,2014.
SCORZONI, L., DE LUCAS, M. P., MESA-ARANGO, A.C., FUSCO-ALMEIDA, A.M., LOZANO, E., CUENCAESTRELLA, M., MENDES-GIANNINI, M. J. S, ZARAGOZA, O. Antifungal efficacy during Candida krusei infection in non-conventional models correlates with the yeast in vitro susceptibility profile. PloS one, 8 (3), e60047, 2013.
SARDI, J.J.O. ; FUSCO-ALMEIDA, A.M. ; Mendes-Giannini, M.J.S. . New antimicrobial therapies used against fungi present in subgingival sites a brief review. Archives of Oral Biology, v. 56, p. 951-959, 2011.
Título do Pedido: “Incorporação de 2-chalcona em sistemas lipídicos nanoestruturados: composição e uso no tratamento da paracoccidioidomicose”Protocolo: Tech ID 13CI035 (AUIN UNESP).

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