CELEX: 32014R0418
Language: en
Date: 2014-04-24 00:00:00
Title: Commission Implementing Regulation (EU) No 418/2014 of 24 April 2014 amending the Annex to Regulation (EU) No 37/2010 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin, as regards the substance ivermectin  Text with EEA relevance

25.4.2014   
            
            
               EN
            
            
               Official Journal of the European Union
            
            
               L 124/19
            
         COMMISSION IMPLEMENTING REGULATION (EU) No 418/2014
   of 24 April 2014
   amending the Annex to Regulation (EU) No 37/2010 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin, as regards the substance ivermectin
   (Text with EEA relevance)
   THE EUROPEAN COMMISSION,
   Having regard to the Treaty on the Functioning of the European Union,
   Having regard to Regulation (EC) No 470/2009 of the European Parliament and of the Council of 6 May 2009 laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin, repealing Council Regulation (EEC) No 2377/90 and amending Directive 2001/82/EC of the European Parliament and of the Council and Regulation (EC) No 726/2004 of the European Parliament and the Council (1), and in particular Article 14 in conjunction with Article 17 thereof,
   Having regard to the opinion of the European Medicines Agency formulated by the Committee for Medicinal Products for Veterinary Use,
   Whereas:
   
               (1)
            
            
               The maximum residue limit (‘MRL’) for pharmacologically active substances intended for use in the Union in veterinary medicinal products for food-producing animals or in biocidal products used in animal husbandry is to be established in accordance with Regulation (EC) No 470/2009.
            
         
               (2)
            
            
               Pharmacologically active substances and their classification regarding MRLs in foodstuffs of animal origin are set out in the Annex to Commission Regulation (EU) No 37/2010 (2).
            
         
               (3)
            
            
               Ivermectin is currently included in Table 1 of the Annex to Regulation (EU) No 37/2010 as an allowed substance, for all mammalian food producing species, applicable to fat, liver and kidney, excluding animals producing milk for human consumption.
            
         
               (4)
            
            
               On 15 December 2010 the Commission requested that the European Medicines Agency issue a new opinion on the substance ivermectin to include the possibility of establishing a MRL for tissue muscle.
            
         
               (5)
            
            
               On 9 June 2011 the Committee for Medicinal Products for Veterinary Use (‘CVMP’) adopted an opinion recommending the establishment of MRLs for ivermectin in tissues, including muscle, for all mammalian food producing species.
            
         
               (6)
            
            
               On 25 October 2011 the Commission requested that the CVMP reconsider its opinion of 9 June 2011 and amend the part referring to residue levels at the injection site in the ‘Other provisions’ of Table 1 of the Annex to Regulation (EU) No 37/2010.
            
         
               (7)
            
            
               On 12 September 2013, the CVMP adopted a revised opinion recommending the establishment of a MRL for ivermectin for all mammalian food producing species, applicable to muscle, fat, liver and kidney, excluding animals from which milk is produced for human consumption. The CVMP recommended in its revised opinion that, for the purpose of monitoring the residues of ivermectin that, where the entire carcass is available, fat, liver or kidney should be sampled in preference to muscle as residues in these tissues deplete more slowly than residues in muscle.
            
         
               (8)
            
            
               The entry for ivermectin in Table 1 of the Annex to Regulation (EU) No 37/2010 should therefore be amended to include MRLs for the pharmaceutical substance for all mammalian food producing species, applicable to muscle, fat, liver and kidney, excluding animals producing milk for human consumption.
            
         
               (9)
            
            
               It is appropriate to provide for a reasonable period of time for the stakeholders concerned to take measures that may be required to comply with the newly set MRL.
            
         
               (10)
            
            
               The measures provided for in this Regulation are in accordance with the opinion of the Standing Committee on Veterinary Medicinal Products,
            
         HAS ADOPTED THIS REGULATION:
   Article 1
   The Annex to Regulation (EU) No 37/2010 is amended as set out in the Annex to this Regulation.
   Article 2
   This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.
   It shall apply from 24 June 2014.
   
      This Regulation shall be binding in its entirety and directly applicable in all Member States.
      Done at Brussels, 24 April 2014.
      
         
            For the Commission
         
         
            The President
         
         José Manuel BARROSO
      
   
   
      (1)  OJ L 152, 16.6.2009, p. 11.
   
      (2)  Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin (OJ L 15, 20.1.2010, p. 1).
   
      ANNEX
      In Table 1 of the Annex to Regulation (EU) No 37/2010, the entry for the substance ivermectin is replaced by the following:
      
         
                     Pharmacologically active substance
                  
                  
                     Marker residue
                  
                  
                     Animal species
                  
                  
                     MRL
                  
                  
                     Target tissues
                  
                  
                     Other provisions (according to Article 14(7) of Regulation (EC) No 470/2009)
                  
                  
                     Therapeutic classification
                  
               
                     ‘Ivermectin
                  
                  
                     22, 23-Dihydro-avermectin B 1a
                  
                  
                     All mammalian food producing species
                  
                  
                     30 μg/kg
                     100 μg/kg
                     100 μg/kg
                     30 μg/kg
                  
                  
                     Muscle
                     Fat
                     Liver
                     Kidney
                  
                  
                     For porcine species the fat MRL relates to “skin and fat in natural proportions”
                     Not for use in animals from which milk is produced for human consumption
                  
                  
                     Antiparasitic agents/Agents acting against endo and ectoparasites’