CELEX: 31993L0021
Language: en
Date: 1993-04-27 00:00:00
Title: Commission Directive 93/21/EEC of 27 April 1993 adapting to technical progress for the 18th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances

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31993L0021

Commission Directive 93/21/EEC of 27 April 1993 adapting to technical progress for the 18th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances  

Official Journal L 110 , 04/05/1993 P. 0020 - 0021 Finnish special edition: Chapter 13 Volume 24 P. 0037  Swedish special edition: Chapter 13 Volume 24 P. 0037 

COMMISSION DIRECTIVE 93/21/EEC of 27 April 1993 adapting to technical progress for the  18th time Council Directive 67/548/EEC on the approximation of the laws, regulations and  administrative provisions relating to the classification, packaging and labelling of dangerous  substancesTHE COMMISSION OF THE EUROPEAN COMMUNITIES, Having regard to the Treaty establishing the European Economic Community, Having regard to Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws,  regulations and administrative provisions relating to the classification, packaging and labelling  of dangerous substances  (1), as last amended by Commission Directive 92/69/EEC  (2), and in  particular Articles 28 and 29 thereof, Whereas Council Directive 92/32/EEC  (3) amends Directive 67/548/EEC as regards the provisions  relating to the classification and labelling of dangerous substances; Whereas Annex II to Directive 67/548/EEC contains the symbols and indications of danger; whereas it  is necessary to introduce a new symbol for 'dangerous for the environment`; Whereas Annex III to Directive 67/548/EEC contains a list of phrases indicating the nature of the  special risks attributed to dangerous substances; whereas it is necessary to introduce new phrases  indicating danger to health for substances toxic to reproduction; whereas it is also necessary to  introduce new combined risk phrases indicating the danger for the environment; Whereas Annex IV to Directive 67/548/EEC contains a list of the phrases indicating the safety  advice concerning dangerous substances; whereas it is necessary to revise certain safety advice  phrases related to the dangers for the environment; whereas it is necessary to introduce certain  combined phrases relating to the use of dangerous substances and preparations; Whereas Annex VI to Directive 67/548/EEC contains a guide to the classification and labelling of  dangerous substances and preparations; whereas it is necessary to amend this guide to include  changes resulting from Directive 92/32/EEC; Whereas the provisions of this Directive are in accordance with the opinion of the Committee on the  Adaptation to Technical Progress of the Directives for the Elimination of Technical Barriers to  Trade in Dangerous Substances and Preparations, HAS ADOPTED THIS DIRECTIVE: Article 1 Directive 67/548/EEC is amended as follows: 1.  Annex II is replaced by Annex I to this Directive; 2.  Annex III is replaced by Annex II to this Directive; 3.  Annex IV is replaced by Annex III to this Directive; 4.  in Annex V, method B.2: Acute toxicity (inhalation), Section 1.6.2.4, (Limit test) is replaced  by the following: '1.6.2.4.  Limit test If an exposure of five male and five female test animals to 20 mg per litre of a gas or 5 mg per  litre of an aerosol or a particulate for four hours (or, where this is not possible due to the  physical or chemical, including explosive, properties of the test substance, the maximum attainable  concentration) produces no compound related mortality within 14 days further testing may not be  considered necessary.`; 5.  Annex VI, Parts I and II are replaced by Annex IV to this Directive. Article 2 1.  Member States shall bring into force the laws, regulations and administrative  provisions necessary to comply with this Directive by 1 July 1994, with the exception of those  applicable to mobile gas cylinders containing butane, propane or liquid petroleum gas. Member  States shall immediately inform the Commission thereof. 2.  Member States shall bring into force the laws, regulations and administrative provisions  necessary to comply with Annex IV, Chapter 8.1 of this Directive in so far as it applies to mobile  gas cylinders containing butane, propane or liquid petroleum gas, by 31 October 1997. Member States  shall immediately inform the Commission thereof. 3.  When Member States adopt the provisions referred to in paragraphs 1 and 2, these shall contain  a reference to this Directive or shall be accompanied by such reference at the time of their  official publication. The procedure for such reference shall be adopted by Member States. Article 3 This Directive is addressed to the Member States. Done at Brussels, 27 April 1993. For the Commission Yannis PALEOKRASSAS Member of the Commission  Annexes I, II, III and IV to Commission Directive 93/21/EEC of 27 April 1993 adapting to  technical progress for the 18th time Council Directive 67/548/EEC on the approximation of the laws,  regulations and administrative provisions relating to the classification, packaging and labelling  of dangerous substances  (1)  ANEXO I - BILAG I - ANHANG I - ÐÁÑÁÑÔÇÌÁ É - ANNEX I - ANNEXE I - ALLEGATO I - BIJLAGE I -  ANEXO I ANEXO II Símbolos e indicaciones de peligro de las sustancias y preparados peligrosos  BILAG II Faresymboler og farebetegnelser for farlige stoffer og praeparater ANHANG II  Gefahrensymbole und -bezeichnungen fuer gefaehrliche Stoffe und Zubereitungen ÐÁÑÁÑÔÇÌÁ ÉÉ  Óýìâïëá êáé aaíaeaassîaaéò êéíaeýíïõ ãéá aaðéêssíaeõíaaò ïõóssaaò êáé ðáñáóêaaõUEóìáôá ANNEX II Symbols and  indications of danger for dangerous substances and preparations ANNEXE II Symboles et  indications de danger des substances et préparations dangereuses ALLEGATO II Simboli e  indicazioni di rischio delle sostanze e preparati pericolosi BIJLAGE II Gevaarsymbolen en  -aanduidingen van gevaarlijke stoffen en preparaten ANEXO II Símbolos e indicações de perigo  das substâncias e preparações perigosas Nota: Las letras E, O, F, F+, T, T+, C, Xn, Xi y N no  forman parte del símbolo. Bemaerkning: Bogstaverne E, O, F, F+, T, T+, C, Xn, Xi og N udgoer ikke en del af symbolet. Anmerkung: Die Buchstaben E, O, F, F+, T, T+, C, Xn, Xi und N sind nicht Bestandteil des  Gefahrensymbols. Óçìaassùóç: Ôá ãñUEììáôá E, O, F, F+, T, T+, C, Xn, Xi êáé N aeaaí áðïôaaëïýí ìÝñïò ôïõ óõìâueëïõ. Note: The letters E, O, F, F+, T, T+, C, Xn, Xi and N do not form part of the symbol. Remarque: Les lettres E, O, F, F+, T, T+, C, Xn, Xi et N ne font pas partie du symbole. Nota: Le lettere E, O, F, F+, T, T+, C, Xn, Xi e N non fanno parte del simbolo. Opmerking: De letters E, O, F, F+, T, T+, C, Xn, Xi en N maken geen deel uit van het  gevaarsymbool. Nota: As letras E, O, F, F+, T, T+, C, Xn, Xi e N não fazem parte do símbolo.  E >REFERENCE TO A GRAPHIC>  ES: Explosivo DA: Eksplosiv DE: Explosionsgefaehrlich EL: AAêñçêôéêue EN: Explosive FR: Explosif IT: Esplosivo NL: Ontplofbaar PT: Explosivo O >REFERENCE TO A GRAPHIC>  ES: Comburente DA: Brandnaerende DE: Brandfoerdernd EL: Ïîaaéaeùôéêue EN: Oxidizing FR: Comburant IT: Comburente NL: Oxyderend PT: Comburente F >REFERENCE TO A GRAPHIC> ES: Fácilmente inflamable DA: Meget  brandfarlig DE: Leichtentzuendlich EL: Ðïëý aaýoeëaaêôï EN: Highly flammable FR: Facilement  inflammable IT: Facilmente infiammabile NL: Licht ontvlambaar PT: Facilmente inflamável F  + >REFERENCE TO A GRAPHIC> ES: Extremadamente inflamable DA: Yderst  brandfarlig DE: Hochentzuendlich EL: AAîáéñaaôéêUE aaýoeëaaêôï EN: Extremely flammable FR: Extrêmement  inflammable IT: Estremamente infiammabile NL: Zeer licht ontvlambaar PT: Extremamente inflamável T >REFERENCE TO A GRAPHIC>  ES: Tóxico DA: Giftig DE: Giftig EL: Ôïîéêue EN: Toxic FR: Toxique IT: Tossico NL: Vergiftig PT: Tóxico T  + >REFERENCE TO A GRAPHIC> ES: Muy tóxico DA: Meget giftig DE: Sehr giftig EL: Ðïëý ôïîéêue EN: Very  toxic FR: Très toxique IT: Molto tossico NL: Zeer vergiftig PT: Muito tóxico C >REFERENCE TO A GRAPHIC>  ES: Corrosivo DA: AEtsende DE: AEtzend EL: AEéáâñùôéêue EN: Corrosive FR: Corrosif IT: Corrosivo NL: Bijtend PT: Corrosivo X >REFERENCE TO A GRAPHIC>  ES: Nocivo DA: Sundhedsskadelig DE: Mindergiftig EL: AAðéâëáâÝò EN: Harmful FR: Nocif IT: Nocivo NL: Schadelijk PT: Nocivo Xi >REFERENCE TO A GRAPHIC>  ES: Irritante DA: Lokalirriterende DE: Reizend EL: AAñaaèéóôéêue EN: Irritant FR: Irritant IT: Irritante NL: Irriterend PT: Irritante N >REFERENCE TO A GRAPHIC> ES: Peligroso para el medio ambiente DA: Miljoefarlig DE: Umweltgefaehrlich EL: AAðéêssíaeõíï ãéá ôï ðaañéâUEëëïí EN: Dangerous for the environment FR: Dangereux  pour  l'environnement IT: Pericoloso  per l'ambiente NL: Milieugevaarlijk PT: Perigoso para o ambiente  ANEXO II - BILAG II - ANHANG II - ÐÁÑÁÑÔÇÌÁ ÉÉ - ANNEX II - ANNEXE II - ALLEGATO II -  BIJLAGE II - ANEXO II ANEXO III Naturaleza de los riesgos específicos atribuidos a las  sustancias y preparados peligrosos BILAG III Arten af de saerlige risici, der er forbundet med  de farlige stoffer og praeparater ANHANG III Bezeichnungen der besonderen Gefahren bei  gefaehrlichen Stoffen und Zubereitungen ÐÁÑÁÑÔÇÌÁ ÉÉÉ OEýóç ôùí aaéaeéêþí êéíaeýíùí ðïõ áoeïñïýí  aaðéêssíaeõíaaò ïõóssaaò êáé ðáñáóêaaõUEóìáôá ANNEX III Nature of special risks attributed to dangerous  substances and preparations ANNEXE III Nature des risques particuliers attribués aux substances  et préparations dangereuses ALLEGATO III Natura dei rischi specifici attribuiti alle sostanze e  preparati pericolosi BIJLAGE III Aard der bijzondere gevaren toegeschreven aan gevaarlijke  stoffen en preparaten ANEXO III Natureza dos riscos específicos atribuídos às substâncias e  preparações perigosas R 1 ES: Explosivo en estado seco. DA: Eksplosiv i toer tilstand. DE: In trockenem Zustand explosionsgefaehrlich. EL: AAêñçêôéêue óaa îçñÞ êáôUEóôáóç. EN: Explosive when dry. FR: Explosif à l'état sec. IT: Esplosivo allo stato secco. NL: In droge toestand ontplofbaar. PT: Explosivo no estado seco. R 2 ES: Riesgo de explosión por choque, fricción, fuego u otras fuentes de ignición. DA: Eksplosionsfarlig ved stoed, gnidning, ild eller andre antaendelseskilder. DE: Durch Schlag, Reibung, Feuer oder andere Zuendquellen explosionsgefaehrlich. EL: Êssíaeõíïò aaêñÞîaaùò áðue êñïýóç, ôñéâÞ, oeùôéUE Þ UEëëaaò ðçãÝò áíáoeëÝîaaùò. EN: Risk of explosion by shock, friction, fire or other sources of ignition. FR: Risque d'explosion par le choc, la friction, le feu ou d'autres sources d'ignition. IT: Rischio di esplosione per urto, sfregamento, fuoco o altre sorgenti d'ignizione. NL: Ontploffingsgevaar door schok, wrijving, vuur of andere ontstekingsoorzaken. PT: Risco de explosão por choque, fricção, fogo ou outras fontes de ignição. R 3 ES: Alto riesgo de explosión por choque, fricción, fuego u otras fuentes de ignición. DA: Meget eksplosionsfarlig ved stoed, gnidning, ild eller andre antaendelseskilder. DE: Durch Schlag, Reibung, Feuer oder andere Zuendquellen besonders explosionsgefaehrlich. EL: Ðïëý ìaaãUEëïò êssíaeõíïò aaêñÞîaaùò áðue êñïýóç, ôñéâÞ, oeùôéUE Þ UEëëaaò ðçãÝò áíáoeëÝîaaùò. EN: Extreme risk of explosion by shock, friction, fire or other sources of ignition. FR: Grand risque d'explosion par le choc, la friction, le feu ou d'autres sources d'ignition. IT: Elevato rischio di esplosione per urto, sfregamento, fuoco o altre sorgenti d'ignizione. NL: Ernstig ontploffingsgevaar door schok, wrijving, vuur of andere ontstekingsoorzaken. PT: Grande risco de explosão por choque, fricção, fogo ou outras fontes de ignição. R 4 ES: Forma compuestos metálicos explosivos muy sensibles. DA: Danner meget foelsomme eksplosive metalforbindelser. DE: Bildet hochempfindliche explosionsgefaehrliche Metallverbindungen. EL: Ó÷çìáôssaeaaé ðïëý aaõássóèçôaaò aaêñçêôéêÝò ìaaôáëëéêÝò aaíþóaaéò. EN: Forms very sensitive explosive metallic compounds. FR: Forme des composés métalliques explosifs très sensibles. IT: Forma composti metallici esplosivi molto sensibili. NL: Vormt met metalen zeer gemakkelijk ontplofbare verbindingen. PT: Forma compostos metálicos explosivos muito sensíveis. R 5 ES: Peligro de explosión en caso de calentamiento. DA: Eksplosionsfarlig ved opvarmning. DE: Beim Erwaermen explosionsfaehig. EL: ÈÝñìáíóç ìðïñaass íá ðñïêáëÝóaaé Ýêñçîç. EN: Heating may cause an explosion. FR: Danger d'explosion sous l'action de la chaleur. IT: Pericolo di esplosione per riscaldamento. NL: Ontploffingsgevaar door verwarming. PT: Perigo de explosão sob a acção do calor. R 6 ES: Peligro de explosión, en contacto o sin contacto con el aire. DA: Eksplosiv ved og uden kontakt med luft. DE: Mit und ohne Luft explosionsfaehig. EL: AAêñçêôéêue óaa aaðáoeÞ Þ ÷ùñssò aaðáoeÞ ìaa ôïí áÝñá. EN: Explosive with or without contact with air. FR: Danger d'explosion en contact ou sans contact avec l'air. IT: Esplosivo a contatto o senza contatto con l'aria. NL: Ontplofbaar met en zonder lucht. PT: Perigo de explosão com ou sem contacto com o ar. R 7 ES: Puede provocar incendios. DA: Kan foraarsage brand. DE: Kann Brand verursachen. EL: Ìðïñaass íá ðñïêáëÝóaaé ðõñêáãéUE. EN: May cause fire. FR: Peut provoquer un incendie. IT: Può provocare un incendio. NL: Kan brand veroorzaken. PT: Pode provocar incêndio. R 8 ES: Peligro de fuego en contacto con materias combustibles. DA: Brandfarlig ved kontakt med braendbare stoffer. DE: Feuergefahr bei Beruehrung mit brennbaren Stoffen. EL: Ç aaðáoeÞ ìaa êáýóéìï õëéêue ìðïñaass íá ðñïêáëÝóaaé ðõñêáãéUE. EN: Contact with combustible material may cause fire. FR: Favorise l'inflammation des matières combustibles. IT: Può provocare l'accensione di materie combustibili. NL: Bevordert de ontbranding van brandbare stoffen. PT: Favorece a inflamação de matérias combustíveis. R 9 ES: Peligro de explosión al mezclar con materias combustibles. DA: Eksplosionsfarlig ved blanding med braendbare stoffer. DE: Explosionsgefahr bei Mischung mit brennbaren Stoffen. EL: AAêñçêôéêue ueôáí áíáìé÷èaass ìaa êáýóéìá õëéêUE. EN: Explosive when mixed with combustible material. FR: Peut exploser en mélange avec des matières combustibles. IT: Esplosivo in miscela con materie combustibili. NL: Ontploffingsgevaar bij menging met brandbare stoffen. PT: Pode explodir quando misturado com matérias combustíveis. R 10 ES: Inflamable. DA: Brandfarlig. DE: Entzuendlich. EL: AAýoeëaaêôï. EN: Flammable. FR: Inflammable. IT: Infiammabile. NL: Ontvlambaar. PT: Inflamável. R 11 ES: Fácilmente inflamable. DA: Meget brandfarlig. DE: Leichtentzuendlich. EL: Ðïëý aaýoeëaaêôï. EN: Highly flammable. FR: Facilement inflammable. IT: Facilmente infiammabile. NL: Licht ontvlambaar. PT: Facilmente inflamável. R 12 ES: Extremadamente inflamable. DA: Yderst brandfarlig. DE: Hochentzuendlich. EL: AAîáéñaaôéêUE aaýoeëaaêôï. EN: Extremely flammable. FR: Extrêmement inflammable. IT: Estremamente infiammabile. NL: Zeer licht ontvlambaar. PT: Extremamente inflamável. R 14 ES: Reacciona violentamente con el agua. DA: Reagerer voldsomt med vand. DE: Reagiert heftig mit Wasser. EL: ÁíôéaeñUE âssáéá ìaa íaañue. EN: Reacts violently with water. FR: Réagit violemment au contact de l'eau. IT: Reagisce violentemente con l'acqua. NL: Reageert heftig met water. PT: Reage violentamente em contacto com a água. R 15 ES: Reacciona con el agua liberando gases extremadamente inflamables. DA: Reagerer med vand under dannelse af yderst brandfarlige gasser. DE: Reagiert mit Wasser unter Bildung hochentzuendlicher Gase.EL: Óaa aaðáoeÞ ìaa ôï íaañue aaêëýaaé aaîáéñaaôéêUE aaýoeëaaêôá áÝñéá. EN: Contact with water liberates extremely flammable gases. FR: Au contact de l'eau, dégage des gaz extrêmement inflammables. IT: A contatto con l'acqua libera gas estremamente infiammabili. NL: Vormt zeer licht ontvlambaar gas in contact met water. PT: Em contacto com a água liberta gases extremamente inflamáveis. R 16 ES: Puede explosionar en mezcla con substancias comburentes. DA: Eksplosionsfarlig ved blanding med oxiderende stoffer. DE: Explosionsgefaehrlich in Mischung mit brandfoerdernden Stoffen. EL: AAêñçêôéêue ueôáí áíáìé÷èaass ìaa ïîaaéaeùôéêÝò ïõóssaaò. EN: Explosive when mixed with oxidizing substances. FR: Peut exploser en mélange avec des substances comburantes. IT: Pericolo di esplosione se mescolato con sostanze comburenti. NL: Ontploffingsgevaar bij menging met oxyderende stoffen. PT: Explosivo quando misturado com substâncias comburentes. R 17 ES: Se inflama espontáneamente en contacto con el aire. DA: Selvantaendelig i luft. DE: Selbstentzuendlich an der Luft. EL: ÁõôïáíáoeëÝãaaôáé óôïí áÝñá. EN: Spontaneously flammable in air. FR: Spontanément inflammable à l'air. IT: Spontaneamente infiammabile all'aria. NL: Spontaan ontvlambaar in lucht. PT: Espontaneamente inflamável ao ar. R 18 ES: Al usarlo pueden formarse mezclas aire-vapor explosivas/inflamables. DA: Ved brug kan braendbare dampe/eksplosive damp-luftblandinger dannes. DE: Bei Gebrauch Bildung explosionsfaehiger/leichtentzuendlicher Dampf/Luft-Gemische moeglich. EL: ÊáôUE ôç ÷ñÞóç ìðïñaass íá ó÷çìáôssóaaé aaýoeëaaêôá/aaêñçêôéêUE ìaassãìáôá áôìïý-áÝñïò. EN: In use, may form flammable/explosive vapour-air mixture. FR: Lors de l'utilisation, formation possible de mélange vapeur-air inflammable/explosif. IT: Durante l'uso può formare con aria miscele esplosive/infiammabili. NL: Kan bij gebruik een ontvlambaar/ontplofbaar damp-luchtmengsel vormen. PT: Pode formar mistura vapor-ar explosiva/inflamável durante a utilização. R 19 ES: Puede formar peróxidos explosivos. DA: Kan danne eksplosive peroxider. DE: Kann explosionsfaehige Peroxide bilden. EL: Ìðïñaass íá ó÷çìáôssóaaé aaêñçêôéêUE õðaañïîaassaeéá. EN: May form explosive peroxides. FR: Peut former des peroxydes explosifs. IT: Può formare perossidi esplosivi. NL: Kan ontplofbare peroxiden vormen. PT: Pode formar peróxidos explosivos. R 20 ES: Nocivo por inhalación. DA: Farlig ved indaanding. DE: Gesundheitsschaedlich beim Einatmen. EL: AAðéâëáâÝò ueôáí aaéóðíÝaaôáé. EN: Harmful by inhalation. FR: Nocif par inhalation. IT: Nocivo per inalazione. NL: Schadelijk bij inademing. PT: Nocivo por inalação. R 21 ES: Nocivo en contacto con la piel. DA: Farlig ved hudkontakt. DE: Gesundheitsschaedlich bei Beruehrung mit der Haut. EL: AAðéâëáâÝò óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Harmful in contact with skin. FR: Nocif par contact avec la peau. IT: Nocivo a contatto con la pelle. NL: Schadelijk bij aanraking met de huid. PT: Nocivo em contacto com a pele. R 22 ES: Nocivo por ingestión. DA: Farlig ved indtagelse. DE: Gesundheitsschaedlich beim Verschlucken. EL: AAðéâëáâÝò óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful if swallowed. FR: Nocif en cas d'ingestion. IT: Nocivo per ingestione. NL: Schadelijk bij opname door de mond. PT: Nocivo por ingestão. R 23 ES: Tóxico por inhalación. DA: Giftig ved indaanding. DE: Giftig beim Einatmen. EL: Ôïîéêue ueôáí aaéóðíÝaaôáé. EN: Toxic by inhalation. FR: Toxique par inhalation. IT: Tossico per inalazione. NL: Vergiftig bij inademing. PT: Tóxico por inalação. R 24 ES: Tóxico en contacto con la piel. DA: Giftig ved hudkontakt. DE: Giftig bei Beruehrung mit der Haut. EL: Ôïîéêue óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Toxic in contact with skin. FR: Toxique par contact avec la peau. IT: Tossico a contatto con la pelle. NL: Vergiftig bij aanraking met de huid. PT: Tóxico em contacto com a pele. R 25 ES: Tóxico por ingestión. DA: Giftig ved indtagelse. DE: Giftig beim Verschlucken. EL: Ôïîéêue óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic if swallowed. FR: Toxique en cas d'ingestion. IT: Tossico per ingestione. NL: Vergiftig bij opname door de mond. PT: Tóxico por ingestão. R 26 ES: Muy tóxico por inhalación. DA: Meget giftig ved indaanding. DE: Sehr giftig beim Einatmen. EL: Ðïëý ôïîéêue ueôáí aaéóðíÝaaôáé. EN: Very toxic by inhalation. FR: Très toxique par inhalation. IT: Molto tossico per inalazione. NL: Zeer vergiftig bij inademing. PT: Muito tóxico por inalação. R 27 ES: Muy tóxico en contacto con la piel. DA: Meget giftig ved hudkontakt. DE: Sehr giftig bei Beruehrung mit der Haut. EL: Ðïëý ôïîéêue óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Very toxic in contact with skin. FR: Très toxique par contact avec la peau. IT: Molto tossico a contatto con la pelle. NL: Zeer vergiftig bij aanraking met de huid. PT: Muito tóxico em contacto com a pele. R 28 ES: Muy tóxico por ingestión. DA: Meget giftig ved indtagelse. DE: Sehr giftig beim Verschlucken. EL: Ðïëý ôïîéêue óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic if swallowed. FR: Très toxique en cas d'ingestion. IT: Molto tossico per ingestione. NL: Zeer vergiftig bij opname door de mond. PT: Muito tóxico por ingestão. R 29 ES: En contacto con agua libera gases tóxicos. DA: Udvikler giftig gas ved kontakt med vand. DE: Entwickelt bei Beruehrung mit Wasser giftige Gase. EL: Óaa aaðáoeÞ ìaa ôï íaañue aaëaaõèaañþíïíôáé ôïîéêUE áÝñéá. EN: Contact with water liberates toxic gas. FR: Au contact de l'eau, dégage des gaz toxiques. IT: A contatto con l'acqua libera gas tossici. NL: Vormt vergiftig gas in contact met water. PT: Em contacto com a água liberta gases tóxicos. R 30 ES: Puede inflamarse fácilmente al usarlo. DA: Kan blive meget brandfarlig under brug. DE: Kann bei Gebrauch leicht entzuendlich werden. EL: ÊáôUE ôç ÷ñÞóç ãssíaaôáé ðïëý aaýoeëaaêôï. EN: Can become highly flammable in use. FR: Peut devenir facilement inflammable pendant l'utilisation. IT: Può divenire facilmente infiammabile durante l'uso. NL: Kan bij gebruik licht ontvlambaar worden. PT: Pode-se tornar facilmente inflamável durante o uso. R 31 ES: En contacto con ácidos libera gases tóxicos. DA: Udvikler giftig gas ved kontakt med syre. DE: Entwickelt bei Beruehrung mit Saeure giftige Gase. EL: Óaa aaðáoeÞ ìaa ïîÝá aaëaaõèaañþíïíôáé ôïîéêUE áÝñéá. EN: Contact with acids liberates toxic gas. FR: Au contact d'un acide, dégage un gaz toxique. IT: A contatto con acidi libera gas tossico. NL: Vormt vergiftige gassen in contact met zuren. PT: Em contacto com ácidos liberta gases tóxicos  R 32 ES: En contacto con ácidos libera gases muy tóxicos. DA: Udvikler meget giftig gas ved kontakt med syre. DE: Entwickelt bei Beruehrung mit Saeure sehr giftige Gase. EL: Óaa aaðáoeÞ ìaa ïîÝá aaëaaõèaañþíïíôáé ðïëý ôïîéêUE áÝñéá. EN: Contact with acids liberates very toxic gas. FR: Au contact d'un acide, dégage un gaz très toxique. IT: A contatto con acidi libera gas molto tossico. NL: Vormt zeer vergiftige gassen in contact met zuren. PT: Em contacto com ácidos liberta gases muito tóxicos. R 33 ES: Peligro de efectos acumulativos. DA: Kan ophobes i kroppen efter gentagen brug. DE: Gefahr kumulativer Wirkungen. EL: Êssíaeõíïò áèñïéóôéêþí aaðéaeñUEóaaùí. EN: Danger of cumulative effects. FR: Danger d'effets cumulatifs. IT: Pericolo di effetti cumulativi. NL: Gevaar voor cumulatieve effecten. PT: Perigo de efeitos cumulativos. R 34 ES: Provoca quemaduras. DA: AEtsningsfare. DE: Verursacht Veraetzungen. EL: Ðñïêáëaass aaãêáýìáôá. EN: Causes burns. FR: Provoque des brûlures. IT: Provoca ustioni. NL: Veroorzaakt brandwonden. PT: Provoca queimaduras. R 35 ES: Provoca quemaduras graves. DA: Alvorlig aetsningsfare. DE: Verursacht schwere Veraetzungen. EL: Ðñïêáëaass óïâáñUE aaãêáýìáôá. EN: Causes severe burns. FR: Provoque de graves brûlures. IT: Provoca gravi ustioni. NL: Veroorzaakt ernstige brandwonden. PT: Provoca queimaduras graves. R 36 ES: Irrita los ojos. DA: Irriterer oejnene. DE: Reizt die Augen. EL: AAñaaèssaeaaé ôá ìUEôéá. EN: Irritating to eyes. FR: Irritant pour les yeux. IT: Irritante per gli occhi. NL: Irriterend voor de ogen. PT: Irritante para os olhos. R 37 ES: Irrita las vías respiratorias. DA: Irriterer aandedraetsorganerne. DE: Reizt die Atmungsorgane. EL: AAñaaèssaeaaé ôï áíáðíaaõóôéêue óýóôçìá. EN: Irritating to respiratory system. FR: Irritant pour les voies respiratoires. IT: Irritante per le vie respiratorie. NL: Irriterend voor de ademhalingswegen. PT: Irritante para as vias respiratórias. R 38 ES: Irrita la piel. DA: Irriterer huden. DE: Reizt die Haut. EL: AAñaaèssaeaaé ôï aeÝñìá. EN: Irritating to skin. FR: Irritant pour la peau. IT: Irritante per la pelle. NL: Irriterend voor de huid. PT: Irritante para a pele. R 39 ES: Peligro de efectos irreversibles muy graves. DA: Fare for varig alvorlig skade paa helbred. DE: Ernste Gefahr irreversiblen Schadens. EL: Êssíaeõíïò ðïëý óïâáñþí ìïíssìùí aaðéaeñUEóaaùí. EN: Danger of very serious irreversible effects. FR: Danger d'effets irréversibles très graves. IT: Pericolo di effetti irreversibili molto gravi. NL: Gevaar voor ernstige onherstelbare effecten. PT: Perigo de efeitos irreversíveis muito graves. R 40 ES: Posibilidad de efectos irreversibles. DA: Mulighed for varig skade paa helbred. DE: Irreversibler Schaden moeglich. EL: Ðéèáíïss êssíaeõíïé ìïíssìùí aaðéaeñUEóaaùí. EN: Possible risks of irreversible effects. FR: Possibilité d'effets irréversibles. IT: Possibilità di effetti irreversibili. NL: Onherstelbare effecten zijn niet uitgesloten. PT: Possibilidades de efeitos irreversíveis. R 41 ES: Riesgo de lesiones oculares graves. DA: Risiko for alvorlig oejenskade. DE: Gefahr ernster Augenschaeden. EL: Êssíaeõíïò óïâáñþí ïoeèáëìéêþí âëáâþí. EN: Risk of serious damage to eyes. FR: Risque de lésions oculaires graves. IT: Rischio di gravi lesioni oculari. NL: Gevaar voor ernstig oogletsel. PT: Risco de graves lesões oculares. R 42 ES: Posibilidad de sensibilización por inhalación. DA: Kan give overfoelsomhed ved indaanding. DE: Sensibilisierung durch Einatmen moeglich. EL: Ìðïñaass íá ðñïêáëÝóaaé aaõáéóèçôïðïssçóç ueôáí aaéóðíÝaaôáé. EN: May cause sensitization by inhalation. FR: Peut entraîner une sensibilisation par inhalation. IT: Può provocare sensibilizzazione per inalazione. NL: Kan overgevoeligheid veroorzaken bij inademing. PT: Pode causar sensibilização por inalação. R 43 ES: Posibilidad de sensibilización en contacto con la piel. DA: Kan give overfoelsomhed ved kontakt med huden. DE: Sensibilisierung durch Hautkontakt moeglich.EL: Ìðïñaass íá ðñïêáëÝóaaé aaõáéóèçôïðïssçóç óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: May cause sensitization by skin contact. FR: Peut entraîner une sensibilisation par contact avec la peau. IT: Può provocare sensibilizzazione per contatto con la pelle. NL: Kan overgevoeligheid veroorzaken bij contact met de huid. PT: Pode causar sensibilização em contacto com a pele. R 44 ES: Riesgo de explosión al calentarlo en ambiente confinado. DA: Eksplosionsfarlig ved opvarmning under indeslutning. DE: Explosionsgefahr bei Erhitzen unter Einschluss. EL: Êssíaeõíïò aaêñÞîaaùò aaUEí èaañìáíèaass õðue ðaañéïñéóìue. EN: Risk of explosion if heated under confinement. FR: Risque d'explosion si chauffé en ambiance confinée. IT: Rischio di esplosione per riscaldamento in ambiente confinato. NL: Ontploffingsgevaar bij verwarming in afgesloten toestand. PT: Risco de explosão se aquecido em ambiente fechado. R 45 ES: Puede causar cáncer. DA: Kan fremkalde kraeft. DE: Kann Krebs erzeugen. EL: Ìðïñaass íá ðñïêáëÝóaaé êáñêssíï. EN: May cause cancer. FR: Peut provoquer le cancer. IT: Può provocare il cancro. Nl: Kan kanker veroorzaken. PT: Pode causar o cancro. R 46 ES: Puede causar alteraciones genéticas hereditarias. DA: Kan foraarsage arvelige genetiske skader. DE: Kann vererbbare Schaeden verursachen. EL: Ìðïñaass íá ðñïêáëÝóaaé êëçñïíïìéêÝò ãaaíaaôéêÝò âëUEâaaò. EN: May cause heritable genetic damage. FR: Peut provoquer des altérations génétiques héréditaires. IT: Può provocare alterazioni genetiche ereditarie. NL: Kan erfelijke genetische schade veroorzaken. PT: Pode causar alterações genéticas hereditárias. R 48 ES: Riesgo de efectos graves para la salud en caso de exposición prolongada. DA: Alvorlig sundhedsfare ved laengere tids paavirkning. DE: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition. EL: Êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðï ðáñáôaaôáìÝíç Ýêèaaóç. EN: Danger of serious damage to health by prolonged exposure. FR: Risque d'effets graves pour la santé en cas d'exposition prolongée. IT: Pericolo di gravi danni per la salute in caso di esposizione prolungata. NL: Gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling. PT: Risco de efeitos graves para a saúde em caso de exposição prolongada. R 49 ES: Puede causar cáncer por inhalación. DA: Kan fremkalde kraeft ved indaanding. DE: Kann Krebs erzeugen beim Einatmen. EL: Ìðïñaass íá ðñïêáëÝóaaé êáñêssíï ueôáí aaéóðíÝaaôáé. EN: May cause cancer by inhalation. FR: Peut provoquer le cancer par inhalation. IT: Può provocare il cancro per inalazione. NL: Kan kanker veroorzaken bij inademing. PT: Pode causar o cancro por inalação. R 50 ES: Muy tóxico para los organismos acuáticos. DA: Meget giftig for organismer, der lever i vand. DE: Sehr giftig fuer Wasserorganismen. EL: Ðïëý ôïîéêue ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò. EN: Very toxic to aquatic organisms. FR: Très toxique pour les organismes aquatiques. IT: Altamente tossico per gli organismi acquatici. NL: Zeer vergiftig voor in het water levende organismen. PT: Muito tóxico para os organismos aquáticos. R 51 ES: Tóxico para los organismos acuáticos. DA: Giftig for organismer, der lever i vand. DE: Giftig fuer Wasserorganismen. EL: Ôïîéêue ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò. EN: Toxic to aquatic organisms. FR: Toxique pour les organismes aquatiques. IT: Tossico per gli organismi acquatici. NL: Vergiftig voor in het water levende organismen. PT: Tóxico para os organismos aquáticos. R 52 ES: Nocivo para los organismos acuáticos. DA: Skadelig for organismer, der lever i vand. DE: Schaedlich fuer Wasserorganismen. EL: AAðéâëáâÝò ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò. EN: Harmful to aquatic organisms. FR: Nocif pour les organismes aquatiques. IT: Nocivo per gli organismi acquatici. NL: Schadelijk voor in het water levende organismen. PT: Nocivo para os organismos aquáticos. R 53 ES: Puede provocar a largo plazo efectos negativos en el medio ambiente acuático. DA: Kan foraarsage uoenskede langtidsvirkninger i vandmiljoeet. DE: Kann in Gewaessern laengerfristig schaedliche Wirkungen haben. EL: Ìðïñaass íá ðñïêáëÝóaaé ìáêñï÷ñueíéaaò aeõóìaaíaassò aaðéðôþóaaéò óôï õaeUEôéíï ðaañéâUEëëïí. EN: May cause long-term adverse effects in the aquatic environment. FR: Peut entraîner des effets néfastes à long terme pour l'environnement aquatique. IT: Può provocare a lungo termine effetti negativi per l'ambiente acquatico. NL: Kan in het aquatisch milieu op lange termijn schadelijke effecten veroorzaken. PT: Pode causar efeitos nefastos a longo prazo no ambiente aquático. R 54 ES: Tóxico para la flora. DA: Giftig for planter. DE: Giftig fuer Pflanzen. EL: Ôïîéêue ãéá ôç ÷ëùñssaeá. EN: Toxic to flora. FR: Toxique pour la flore. IT: Tossico per la flora. NL: Vergiftig voor planten. PT: Tóxico para a flora. R 55 ES: Tóxico para la fauna. DA: Giftig for dyr. DE: Giftig fuer Tiere. EL: Ôïîéêue ãéá ôçí ðáíssaeá. EN: Toxic to fauna. FR: Toxique pour la faune. IT: Tossico per la fauna. NL: Vergiftig voor dieren. PT: Tóxico para a fauna. R 56 ES: Tóxico para los organismos del suelo. DA: Giftig for organismer i jordbunden. DE: Giftig fuer Bodenorganismen. EL: Ôïîéêue ãéá ôïõò ïñãáíéóìïýò ôïõ aaaeUEoeïõò. EN: Toxic to soil organisms. FR: Toxique pour les organismes du sol. IT: Tossico per gli organismi del terreno. NL: Vergiftig voor bodemorganismen. PT: Tóxico para os organismos do solo. R 57 ES: Tóxico para las abejas. DA: Giftig for bier. DE: Giftig fuer Bienen. EL: Ôïîéêue ãéá ôéò ìÝëéóóaaò. EN: Toxic to bees. FR: Toxique pour les abeilles. IT: Tossico per le api. NL: Vergiftig voor bijen. PT: Tóxico para as abelhas. R 58 ES: Puede provocar a largo plazo efectos negativos en el medio ambiente. DA: Kan foraarsage uoenskede langtidsvirkninger i miljoeet. DE: Kann laengerfristig schaedliche Wirkungen auf die Umwelt haben. EL: Ìðïñaass íá ðñïêáëÝóaaé ìáêñï÷ñueíéaaò aeõóìaaíaassò aaðéðôþóaaéò óôï ðaañéâUEëëïí. EN: May cause long-term adverse effects in the environment. FR: Peut entraîner des effets néfastes à long terme pour l'environnement. IT: Può provocare a lungo termine effetti negativi per l'ambiente. NL: Kan in het milieu op lange termijn schadelijke effecten veroorzaken. PT: Pode causar efeitos nefastos a longo prazo no ambiente. R 59 ES: Peligroso para la capa de ozono. DA: Farlig for ozonlaget. DE: Gefaehrlich fuer die Ozonschicht. EL: AAðéêssíaeõíï ãéá ôç óôéâUEaeá ôïõ ueaeïíôïò. EN: Dangerous for the ozone layer. FR: Dangereux pour la couche d'ozone. IT: Pericoloso per lo strato di ozono. NL: Gevaarlijk voor de ozonlaag. PT: Perigoso para a camada de ozónio. R 60 ES: Puede perjudicar la fertilidad. DA: Kan skade forplantningsevnen. DE: Kann die Fortpflanzungsfaehigkeit beeintraechtigen. EL: Ìðïñaass íá aaîáóèaaíssóaaé ôç ãïíéìueôçôá. EN: May impair fertility. FR: Peut altérer la fertilité. IT: Può ridurre la fertilità. NL: Kan de vruchtbaarheid schaden. PT: Pode comprometer a fertilidade. R 61 ES: Riesgo durante el embarazo de efectos adversos para el feto. DA: Kan skade barnet under graviditeten. DE: Kann das Kind im Mutterleib schaedigen. EL: Ìðïñaass íá âëUEoeaaé ôï Ýìâñõï êáôUE ôç aeéUEñêaaéá ôçò êýçóçò. EN: May cause harm to the unborn child. FR: Risque pendant la grossesse d'effets néfastes pour l'enfant. IT: Può danneggiare i bambini non ancora nati. NL: Kan het ongeboren kind schaden. PT: Risco durante a gravidez com efeitos adversos na descendência. R 62 ES: Posible riesgo de perjudicar la fertilidad. DA: Mulighed for skade paa forplantningsevnen. DE: Kann moeglicherweise die Fortpflanzungsfaehigkeit beeintraechtigen. EL: Ðéèáíueò êssíaeõíïò ãéá aaîáóèÝíçóç ôçò ãïíéìueôçôáò. EN: Possible risk of impaired fertility. FR: Risque possible d'altération de la fertilité. IT: Possibile rischio di ridotta fertilità. NL: Mogelijk gevaar voor verminderde vruchtbaarheid. PT: Possíveis riscos de comprometer a fertilidade. R 63 ES: Posible riesgo durante el embarazo de efectos adversos para el feto. DA: Mulighed for skade paa barnet under graviditeten. DE: Kann das Kind im Mutterleib moeglicherweise schaedigen. EL: Ðéèáíueò êssíaeõíïò aeõóìaaíþí aaðéaeñUEóaaùí óôï Ýìâñõï êáôUE ôç aeéUEñêaaéá ôçò êýçóçò. EN: Possible risk of harm to the unborn child. FR: Risque possible pendant la grossesse d'effets néfastes pour l'enfant. IT: Possibile rischio di danni ai bambini non ancora nati. NL: Mogelijk gevaar voor beschadiging van het ongeboren kind. PT: Possíveis riscos durante a gravidez de efeitos indesejáveis na descendência. R 64 ES: Puede perjudicar a los niños alimentados con leche materna. DA: Kan skade boern i ammeperioden. DE: Kann Saeuglinge ueber die Muttermilch schaedigen. EL: Ìðïñaass íá âëUEoeaaé ôá âñÝoeç ðïõ ôñÝoeïíôáé ìaa ìçôñéêue ãUEëá. EN: May cause harm to breastfed babies. FR: Risque possible pour les bébés nourris au lait maternel. IT: Possibile rischio per i bambini allattati al seno. NL: Kan schadelijk zijn via de borstvoeding. PT: Pode causar danos nas crianças alimentadas com leite materno.  Combinación de frases-R. Kombination af R-saetninger. Kombination der R-Saetze. Óõíaeõáóìueò ôùí  R-  oeñUEóaaùí. Combination of R-phrases. Combinaison des phrases R. Combinazioni delle frasi R.  Combinatie van R-zinnen. Combinação das frases R. R 14/15 ES: Reacciona violentamente con el agua, liberando gases extremadamente inflamables. DA: Reagerer voldsomt med vand under dannelse af yderst brandfarlige gasser. DE: Reagiert heftig mit Wasser unter Bildung hochentzuendlicher Gase. EL: ÁíôéaeñUE âssáéá óaa aaðáoeÞ ìaa íaañue aaêëýïíôáò áÝñéá aaîue÷ùò aaýoeëaaêôá. EN: Reacts violently with water, liberating extremely flammable gases. FR: Réagit violemment au contact de l'eau en dégageant des gaz extrêmement inflammables. IT: Reagisce violentemente con l'acqua liberando gas estremamente infiammabili. NL: Reageert heftig met water en vormt daarbij zeer ontvlambaar gas. PT: Reage violentamente com a água libertando gases extremamente inflamáveis. R 15/29 ES: En contacto con el agua, libera gases tóxicos y extremadamente inflamables. DA: Reagerer med vand under dannelse af giftige og yderst brandfarlige gasser. DE: Reagiert mit Wasser unter Bildung giftiger und hochentzuendlicher Gase. EL: Óaa aaðáoeÞ ìaa íaañue aaëaaõèaañþíïíôáé ôïîéêUE, aaîue÷ùò aaýoeëaaêôá áÝñéá. EN: Contact with water liberates toxic, extremely flammable gas. FR: Au contact de l'eau, dégage des gaz toxiques et extrêmement inflammables. IT: A contatto con acqua libera gas tossici e estremamente infiammabili. NL: Vormt vergiftig en zeer ontvlambaar gas in contact met water. PT: Em contacto com a água liberta gases tóxicos e extremamente inflamáveis. R 20/21 ES: Nocivo por inhalación y en contacto con la piel. DA: Farlig ved indaanding og ved hudkontakt. DE: Gesundheitsschaedlich beim Einatmen und bei Beruehrung mit der Haut. EL: AAðéâëáâÝò ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Harmful by inhalation and in contact with skin. FR: Nocif par inhalation et par contact avec la peau. IT: Nocivo per inalazione e contatto con la pelle. NL: Schadelijk bij inademing en bij aanraking met de huid. PT: Nocivo por inalação e em contacto com a pele. R 20/22 ES: Nocivo por inhalación y por ingestión. DA: Farlig ved indaanding og ved indtagelse. DE: Gesundheitsschaedlich beim Einatmen und Verschlucken. EL: AAðéâëáâÝò ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful by inhalation and if swallowed. FR: Nocif par inhalation et par ingestion. IT: Nocivo per inalazione e ingestione. NL: Schadelijk bij inademing en opname door de mond. PT: Nocivo por inalação e ingestão. R 20/21/22 ES: Nocivo por inhalación, por ingestión y en contacto con la piel. DA: Farlig ved indaanding, ved hudkontakt og ved indtagelse. DE: Gesundheitsschaedlich beim Einatmen, Verschlucken und Beruehrung mit der Haut. EL: AAðéâëáâÝò ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful by inhalation, in contact with skin and if swallowed. FR: Nocif par inhalation, par contact avec la peau et par ingestion. IT: Nocivo per inalazione, contatto con la pelle e per ingestione. NL: Schadelijk bij inademing, opname door de mond en aanraking met de huid. PT: Nocivo por inalação, em contacto com a pele e por ingestão. R 21/22 ES: Nocivo en contacto con la piel y por ingestión. DA: Farlig ved hudkontakt og ved indtagelse.DE: Gesundheitsschaedlich bei Beruehrung mit der Haut und beim Verschlucken. EL: AAðéâëáâÝò óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful in contact with skin and if swallowed. FR: Nocif par contact avec la peau et par ingestion. IT: Nocivo a contatto con la pelle e per ingestione. NL: Schadelijk bij aanraking met de huid en bij opname door de mond. PT: Nocivo em contacto com a pele e por ingestão. R 23/24 ES: Tóxico por inhalación y en contacto con la piel. DA: Giftig ved indaanding og ved hudkontakt. DE: Giftig beim Einatmen und bei Beruehrung mit der Haut. EL: Ôïîéêue ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Toxic by inhalation and in contact with skin. FR: Toxique par inhalation et par contact avec la peau. IT: Tossico per inalazione e contatto con la pelle. NL: Vergiftig bij inademing en bij aanraking met de huid. PT: Tóxico por inalação e em contacto com a pele. R 23/25 ES: Tóxico por inhalación y por ingestión. DA: Giftig ved indaanding og ved indtagelse. DE: Giftig beim Einatmen und Verschlucken. EL: Ôïîéêue ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic by inhalation and if swallowed. FR: Toxique par inhalation et par ingestion. IT: Tossico per inalazione e ingestione. NL: Vergiftig bij inademing en opname door de mond. PT: Tóxico por inalação e ingestão. R 23/24/25 ES: Tóxico por inhalación, por ingestión y en contacto con la piel. DA: Giftig ved indaanding, ved hudkontakt og ved indtagelse. DE: Giftig beim Einatmen, Verschlucken und Beruehrung mit der Haut. EL: Ôïîéêue ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic by inhalation, in contact with skin and if swallowed. FR: Toxique par inhalation, par contact avec la peau et par ingestion. IT: Tossico per inalazione, contatto con la pelle e per ingestione. NL: Vergiftig bij inademing, opname door de mond en aanraking met de huid. PT: Tóxico por inalação, em contacto com a pele e por ingestão. R 24/25 ES: Tóxico en contacto con la piel y por ingestión. DA: Giftig ved hudkontakt og ved indtagelse. DE: Giftig bei Beruehrung mit der Haut und beim Verschlucken. EL: Ôïîéêue óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic in contact with skin and if swallowed. FR: Toxique par contact avec la peau et par ingestion. IT: Tossico a contatto con la pelle e per ingestione. NL: Vergiftig bij aanraking met de huid en bij opname door de mond. PT: Tóxico em contacto com a pele e por ingestão. R 26/27 ES: Muy tóxico por inhalación y en contacto con la piel. DA: Meget giftig ved indaanding og ved hudkontakt. DE: Sehr giftig beim Einatmen und bei Beruehrung mit der Haut. EL: Ðïëý ôïîéêue ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Very toxic by inhalation and in contact with skin. FR: Très toxique par inhalation et par contact avec la peau. IT: Molto tossico per inalazione e contatto con la pelle. NL: Zeer vergiftig bij inademing en bij aanraking met de huid. PT: Muito tóxico por inalação e em contacto com a pele. R 26/28 ES: Muy tóxico por inhalación y por ingestión. DA: Meget giftig ved indaanding og ved indtagelse. DE: Sehr giftig beim Einatmen und Verschlucken. EL: Ðïëý ôïîéêue ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic by inhalation and if swallowed. FR: Très toxique par inhalation et par ingestion. IT: Molto tossico per inalazione e per ingestione. NL: Zeer vergiftig bij inademing en opname door de mond. PT: Muito tóxico por inalação e ingestão. R 26/27/28 ES: Muy tóxico por inhalación, por ingestión y en contacto con la piel. DA: Meget giftig ved indaanding, ved hudkontakt og ved indtagelse. DE: Sehr giftig beim Einatmen, Verschlucken und Beruehrung mit der Haut. EL: Ðïëý ôïîéêue ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic by inhalation, in contact with skin and if swallowed. FR: Très toxique par inhalation, par contact avec la peau et par ingestion. IT: Molto tossico per inalazione, contatto con la pelle e per ingestione. NL: Zeer vergiftig bij inademing, opname door de mond en aanraking met de huid. PT: Muito tóxico por inalação, em contacto com a pele e por ingestão. R 27/28 ES: Muy tóxico en contacto con la piel y por ingestión. DA: Meget giftig ved hudkontakt og ved indtagelse. DE: Sehr giftig bei Beruehrung mit der Haut und beim Verschlucken. EL: Ðïëý ôïîéêue óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic in contact with skin and if swallowed. FR: Très toxique par contact avec la peau et par ingestion. IT: Molto tossico a contatto con la pelle e per ingestione. NL: Zeer vergiftig bij aanraking met de huid en bij opname door de mond. PT: Muito tóxico em contacto com a pele e por ingestão. R 36/37 ES: Irrita los ojos y las vías respiratorias. DA: Irriterer oejnene og aandedraetsorganerne. DE: Reizt die Augen und die Atmungsorgane. EL: AAñaaèssaeaaé ôá ìUEôéá êáé ôï áíáðíaaõóôéêue óýóôçìá. EN: Irritating to eyes and respiratory system. FR: Irritant pour les yeux et les voies respiratoires. IT: Irritante per gli occhi e le vie respiratorie. NL: Irriterend voor de ogen en de ademhalingswegen. PT: Irritante para os olhos e vias respiratórias. R 36/38 ES: Irrita los ojos y la piel. DA: Irriterer oejnene og huden. DE: Reizt die Augen und die Haut. EL: AAñaaèssaeaaé ôá ìUEôéá êáé ôï aeÝñìá. EN: Irritating to eyes and skin. FR: Irritant pour les yeux et la peau. IT: Irritante per gli occhi e la pelle. NL: Irriterend voor de ogen en de huid. PT: Irritante para os olhos e pele. R 36/37/38 ES: Irrita los ojos, la piel y las vías respiratorias. DA: Irriterer oejnene, aandedraetsorganerne og huden. DE: Reizt die Augen, Atmungsorgane und die Haut. EL: AAñaaèssaeaaé ôá ìUEôéá, ôï áíáðíaaõóôéêue óýóôçìá êáé ôï aeÝñìá. EN: Irritating to eyes, respiratory system and skin. FR: Irritant pour les yeux, les voies respiratoires et la peau. IT: Irritante per gli occhi, le vie respiratorie e la pelle. NL: Irriterend voor de ogen, de ademhalingswegen en de huid. PT: Irritante para os olhos, vias respiratórias e pele. R 37/38 ES: Irrita las vías respiratorias y la piel. DA: Irriterer aandedraetsorganerne og huden. DE: Reizt die Atmungsorgane und die Haut. EL: AAñaaèssaeaaé ôï áíáðíaaõóôéêue óýóôçìá êáé ôï aeÝñìá. EN: Irritating to respiratory system and skin. FR: Irritant pour les voies respiratoires et la peau. IT: Irritante per le vie respiratorie e la pelle. NL: Irriterend voor de ademhalingswegen en de huid. PT: Irritante para as vias respiratórias e pele. R 39/23 ES: Tóxico: peligro de efectos irreversibles muy graves por inhalación. DA: Giftig: fare for varig alvorlig skade paa helbred ved indaanding. DE: Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé. EN: Toxic: danger of very serious irreversible effects through inhalation. FR: Toxique: danger d'effets irréversibles très graves par inhalation. IT: Tossico: pericolo di effetti irreversibili molto gravi per inalazione. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing. PT: Tóxico: perigo de efeitos irreversíveis muito graves por inalação. R 39/24 ES: Tóxico: peligro de efectos irreversibles muy graves por contacto con la piel. DA: Giftig: fare for varig alvorlig skade paa helbred ved hudkontakt. DE: Giftig: ernste Gefahr irreversiblen Schadens bei Beruehrung mit der Haut. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Toxic: danger of very serious irreversible effects in contact with skin. FR: Toxique: danger d'effets irréversibles très graves par contact avec la peau. IT: Tossico: pericolo di effetti irreversibili molto gravi a contatto con la pelle. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij aanraking met de huid. PT: Tóxico: perigo de efeitos irreversíveis muito graves em contacto com a pele. R 39/25 ES: Tóxico: peligro de efectos irreversibles muy graves por ingestión. DA: Giftig: fare for varig alvorlig skade paa helbred ved indtagelse. DE: Giftig: ernste Gefahr irreversiblen Schadens durch Verschlucken. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of very serious irreversible effects if swallowed. FR: Toxique: danger d'effets irréversibles très graves par ingestion. IT: Tossico: pericolo di effetti irreversibili molto gravi per ingestione. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij opname door de mond. PT: Tóxico: perigo de efeitos irreversíveis muito graves por ingestão. R 39/23/24 ES: Tóxico: peligro de efectos irreversibles muy graves por inhalación y contacto con la piel. DA: Giftig: fare for varig alvorlig skade paa helbred ved indaanding og hudkontakt. DE: Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen und bei Beruehrung mit der Haut. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Toxic: danger of very serious irreversible effects through inhalation and in contact with  skin. FR: Toxique: danger d'effets irréversibles très graves par inhalation et par contact avec la peau. IT: Tossico: pericolo di effetti irreversibili molto gravi per inalazione e a contatto con la  pelle. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing en aanraking met de huid. PT: Tóxico: perigo de efeitos irreversíveis muito graves por inalação e em contacto com a pele. R 39/23/25 ES: Tóxico: peligro de efectos irreversibles muy graves por inhalación e ingestión. DA: Giftig: fare for varig alvorlig skade paa helbred ved indaanding og indtagelse. DE: Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen und durch Verschlucken. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of very serious irreversible effects through inhalation and if swallowed. FR: Toxique: danger d'effets irréversibles très graves par inhalation et par ingestion. IT: Tossico: pericolo di effetti irreversibili molto gravi per inalazione ed ingestione. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing en opname door de mond. PT: Tóxico: perigo de efeitos irreversíveis muito graves por inalação e ingestão.  R 39/24/25 ES: Tóxico: peligro de efectos irreversibles muy graves por contacto con la piel e ingestión. DA: Giftig: fare for varig alvorlig skade paa helbred ved hudkontakt og indtagelse. DE: Giftig: ernste Gefahr irreversiblen Schadens bei Beruehrung mit der Haut und durch  Verschlucken. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Toxic: danger of very serious irreversible effects in contact with skin and if swallowed. FR: Toxique: danger d'effets irréversibles très graves par contact avec la peau et par ingestion. IT: Tossico: pericolo di effetti irreversibili molto gravi a contatto con la pelle e per  ingestione. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij aanraking met de huid en opname door  de mond. PT: Tóxico: perigo de efeitos irreversíveis muito graves em contacto com a pele e por ingestão. R 39/23/24/25 ES: Tóxico: peligro de efectos irreversibles muy graves por inhalación, contacto con la piel e  ingestión. DA: Giftig: fare for varig alvorlig skade paa helbred ved indaanding, hudkontakt og indtagelse. DE: Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Beruehrung mit der Haut und durch  Verschlucken. EL: Ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa  ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and  if swallowed. FR: Toxique: danger d'effets irréversibles très graves par inhalation, par contact avec la peau et  par ingestion. IT: Tossico: pericolo di effetti irreversibili molto gravi per inalazione, a contatto con la pelle  e per ingestione. NL: Vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing, aanraking met de huid en  opname door de mond. PT: Tóxico: perigo de efeitos irreversíveis muito graves por inalação, em contacto com a pele e por  ingestão. R 39/26 ES: Muy tóxico: peligro de efectos irreversibles muy graves por inhalación. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved indaanding. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens durch Einatmen. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé. EN: Very toxic: danger of very serious irreversible effects through inhalation. FR: Très toxique: danger d'effets irréversibles très graves par inhalation. IT: Molto tossico: pericolo di effetti irreversibili molto gravi per inalazione. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves por inalação. R 39/27 ES: Muy tóxico: peligro de efectos irreversibles muy graves por contacto con la piel. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved hudkontakt. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens bei Beruehrung mit der Haut. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Very toxic: danger of very serious irreversible effects in contact with skin. FR: Très toxique: danger d'effets irréversibles très graves par contact avec la peau. IT: Molto tossico: pericolo di effetti irreversibili molto gravi a contatto con la pelle. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij aanraking met de huid. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves em contacto com a pele. R 39/28 ES: Muy tóxico: peligro de efectos irreversibles muy graves por ingestión. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved indtagelse. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens durch Verschlucken. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic: danger of very serious irreversible effects if swallowed. FR: Très toxique: danger d'effets irréversibles très graves par ingestion. IT: Molto tossico: pericolo di effetti irreversibili molto gravi per ingestione. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij opname door de mond. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves por ingestão. R 39/26/27 ES: Muy tóxico: peligro de efectos irreversibles muy graves por inhalación y contacto con la piel. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved indaanding og hudkontakt. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens durch Einatmen und bei Beruehrung mit der  Haut. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï  aeÝñìá. EN: Very toxic: danger of very serious irreversible effects through inhalation and in contact with  skin. FR: Très toxique: danger d'effets irréversibles très graves par inhalation et par contact avec la  peau. IT: Molto tossico: pericolo di effetti irreversibili molto gravi per inalazione e a contatto con la  pelle. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing en aanraking met de  huid. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves por inalação e em contacto com a  pele. R 39/26/28 ES: Muy tóxico: peligro de efectos irreversibles muy graves por inhalación e ingestión. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved indaanding og indtagelse. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens durch Einatmen und durch Verschlucken. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Very toxic: danger of very serious irreversible effects through inhalation and if swallowed. FR: Très toxique: danger d'effets irréversibles très graves par inhalation et par ingestion. IT: Molto tossico: pericolo di effetti irreversibili molto gravi per inalazione ed ingestione. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing en opname door de  mond. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves por inalação e ingestão. R 39/27/28 ES: Muy tóxico: peligro de efectos irreversibles muy graves por contacto con la piel e ingestión. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved hudkontakt og indtagelse. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens bei Beruehrung mit der Haut und durch  Verschlucken. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Very toxic: danger of very serious irreversible effects in contact with skin and if swallowed. FR: Très toxique: danger d'effets irréversibles très graves par contact avec la peau et par  ingestion. IT: Molto tossico: pericolo di effetti irreversibili molto gravi a contatto con la pelle e per  ingestione. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij aanraking met de huid en opname  door de mond. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves em contacto com a pele e por  ingestão. R 39/26/27/28 ES: Muy tóxico: peligro de efectos irreversibles muy graves por inhalación, contacto con la piel e  ingestión. DA: Meget giftig: fare for varig alvorlig skade paa helbred ved indaanding, hudkontakt og  indtagelse. DE: Sehr giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Beruehrung mit der Haut und  durch Verschlucken. EL: Ðïëý ôïîéêue: êssíaeõíïò ðïëý óïâáñþí ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé  óaa ðaañssðôùóç êáôáðueóaaùò. EN: Very toxic: danger of very serious irreversible effects through inhalation, in contact with  skin and if swallowed. FR: Très toxique: danger d'effets irréversibles très graves par inhalation, par contact avec la  peau et par ingestion. IT: Molto tossico: pericolo di effetti irreversibili molto gravi per inalazione, a contatto con la  pelle e per ingestione. NL: Zeer vergiftig: gevaar voor ernstige onherstelbare effecten bij inademing, aanraking met de  huid en opname door de mond. PT: Muito tóxico: perigo de efeitos irreversíveis muito graves por inalação, em contacto com a pele  e por ingestão. R 40/20 ES: Nocivo: posibilidad de efectos irreversibles por inhalación. DA: Farlig: mulighed for varig skade paa helbred ved indaanding. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens durch Einatmen. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé. EN: Harmful: possible risk of irreversible effects through inhalation. FR: Nocif: possibilité d'effets irréversibles par inhalation. IT: Nocivo: possibilità di effetti irreversibili per inalazione. NL: Schadelijk: bij inademing zijn onherstelbare effecten niet uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis por inalação. R 40/21 ES: Nocivo: posibilidad de efectos irreversibles en contacto con la piel.DA: Farlig: mulighed for varig skade paa helbred ved hudkontakt. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens bei Beruehrung mit der Haut. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Harmful: possible risk of irreversible effects in contact with skin. FR: Nocif: possibilité d'effets irréversibles par contact avec la peau. IT: Nocivo: possibilità di effetti irreversibili a contatto con la pelle. NL: Schadelijk: bij aanraking met de huid zijn onherstelbare effecten niet uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis em contacto com a pele. R 40/22 ES: Nocivo: posibilidad de efectos irreversibles por ingestión. DA: Farlig: mulighed for varig skade paa helbred ved indtagelse. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens durch Verschlucken. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful: possible risk of irreversible effects if swallowed. FR: Nocif: possibilité d'effets irréversibles par ingestion. IT: Nocivo: possibilità di effetti irreversibili per ingestione. NL: Schadelijk: bij opname door de mond zijn onherstelbare effecten niet uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis por ingestão. R 40/20/21 ES: Nocivo: posibilidad de efectos irreversibles por inhalación y contacto con la piel. DA: Farlig: mulighed for varig skade paa helbred ved indaanding og hudkontakt. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens durch Einatmen und bei Beruehrung mit  der Haut. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Harmful: possible risk of irreversible effects through inhalation and in contact with skin. FR: Nocif: possibilité d'effets irréversibles par inhalation et par contact avec la peau. IT: Nocivo: possibilità di effetti irreversibili per inalazione e a contatto con la pelle. NL: Schadelijk: bij inademing en aanraking met de huid zijn onherstelbare effecten niet  uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis por inalação e em contacto com a pele. R 40/20/22 ES: Nocivo: Posibilidad de efectos irreversibles por inhalación e ingestión. DA: Farlig: mulighed for varig skade paa helbred ved indaanding og indtagelse. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens durch Einatmen und durch  Verschlucken. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful: possible risk of irreversible effects through inhalation and if swallowed. FR: Nocif: possibilité d'effets irréversibles par inhalation et par ingestion. IT: Nocivo: possibilità di effetti irreversibili per inalazione ed ingestione. NL: Schadelijk: bij inademing en opname door de mond zijn onherstelbare effecten niet uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis por inalação e ingestão.  R 40/21/22 ES: Nocivo: posibilidad de efectos irreversibles en contacto con la piel e ingestión. DA: Farlig: mulighed for varig skade paa helbred ved hudkontakt og indtagelse. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens bei Beruehrung mit der Haut und durch  Verschlucken. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Harmful: possible risk of irreversible effects in contact with skin and if swallowed. FR: Nocif: possibilité d'effets irréversibles par contact avec la peau et par ingestion. IT: Nocivo: possibilità di effetti irreversibili a contatto con la pelle e per ingestione. NL: Schadelijk: bij aanraking met de huid en opname door de mond zijn onherstelbare effecten niet  uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis em contacto com a pele e por ingestão. R 40/20/21/22 ES: Nocivo: posibilidad de efectos irreversibles por inhalación, contacto con la piel e ingestión. DA: Farlig: mulighed for varig skade paa helbred ved indaanding, hudkontakt og indtagelse. DE: Gesundheitsschaedlich: Moeglichkeit irreversiblen Schadens durch Einatmen, Beruehrung mit der Haut  und durch Verschlucken. EL: AAðéâëáâÝò: ðéèáíïss êssíaeõíïé ìueíéìùí aaðéaeñUEóaaùí ueôáí aaéóðíÝaaôáé, óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa  ðaañssðôùóç êáôáðueóaaùò.EN: Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if  swallowed. FR: Nocif: possibilité d'effets irréversibles par inhalation, par contact avec la peau et par  ingestion. IT: Nocivo: possibilità di effetti irreversibili per inalazione, a contatto con la pelle e per  ingestione. NL: Schadelijk: bij inademing, aanraking met de huid en opname door de mond zijn onherstelbare  effecten niet uitgesloten. PT: Nocivo: possibilidade de efeitos irreversíveis por inalação, em contacto com a pele e por  ingestão. R 42/43 ES: Posibilidad de sensibilización por inhalación y en contacto con la piel. DA: Kan give overfoelsomhed ved indaanding og ved kontakt med huden. DE: Sensibilisierung durch Einatmen und Hautkontakt moeglich. EL: Ìðïñaass íá ðñïêáëÝóaaé aaõáéóèçôïðïssçóç ueôáí aaéóðíÝaaôáé êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: May cause sensitization by inhalation and skin contact. FR: Peut entraîner une sensibilisation par inhalation et par contact avec la peau. IT: Può provocare sensibilizzazione per inalazione e contatto con la pelle. NL: Kan overgevoeligheid veroorzaken bij inademing of contact met de huid. PT: Pode causar sensibilização por inalação e em contacto com a pele. R 48/20 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por  inhalación. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch  Einatmen. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé. EN: Harmful: danger of serious damage to health by prolonged exposure through inhalation. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation. IT: Nocivo: pericolo di gravi danni per la salute in caso di esposizione prolungata per  inalazione. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação. R 48/21 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por contacto  con la piel. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved hudkontakt. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Beruehrung  mit der Haut. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa aaðáoeÞ ìaa ôï  aeÝñìá. EN: Harmful: danger of serious damage to health by prolonged exposure in contact with skin. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par contact avec la  peau. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata a contatto con la  pelle. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  aanraking met de huid. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada em contacto com a  pele. R 48/22 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por ingestión. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved indtagelse. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch  Verschlucken. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Harmful: danger of serious damage to health by prolonged exposure if swallowed. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par ingestion. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata per ingestione. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  opname door de mond. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada por ingestão. R 48/20/21 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación  y contacto con la piel. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding og hudkontakt. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen  und durch Beruehrung mit der Haut. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé  êáé óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Harmful: danger of serious damage to health by prolonged exposure through inhalation and in  contact with skin. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation et par  contact avec la peau. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione e  a contatto con la pelle. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing en aanraking met de huid. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação e em  contacto com a pele. R 48/20/22 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación  e ingestión. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding og indtagelse. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen  und durch Verschlucken. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé  êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful: danger of serious damage to health by prolonged exposure through inhalation and if  swallowed. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation et par  ingestion. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione e  ingestione. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing en opname door de mond. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação e  ingestão. R 48/21/22 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por contacto  con la piel e ingestión. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved hudkontakt og indtagelse. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Beruehrung  mit der Haut und durch Verschlucken. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa aaðáoeÞ ìaa ôï  aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful: danger of serious damage to health by prolonged exposure in contact with skin and if  swallowed. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par contact avec la  peau et par ingestion. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata a contatto con la  pelle e per ingestione. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  aanraking met de huid en opname door de mond. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada em contacto com a  pele e por ingestão. R 48/20/21/22 ES: Nocivo: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación,  contacto con la piel e ingestión. DA: Farlig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding, hudkontakt og  indtagelse. DE: Gesundheitsschaedlich: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen,  Beruehrung mit der Haut und durch Verschlucken. EL: AAðéâëáâÝò: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé,  óaa aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Harmful: danger of serious damage to health by prolonged exposure through inhalation, in  contact with skin and if swallowed. FR: Nocif: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation, par  contact avec la peau et par ingestion. IT: Nocivo: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione, a  contatto con la pelle e per ingestione. NL: Schadelijk: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing, aanraking met de huid en opname door de mond. PT: Nocivo: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação, em  contacto com a pele e por ingestão. R 48/23 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por  inhalación. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé. EN: Toxic: danger of serious damage to health by prolonged exposure through inhalation. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação. R 48/24 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por contacto  con la piel. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved hudkontakt. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Beruehrung mit der  Haut. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa aaðáoeÞ ìaa ôï  aeÝñìá. EN: Toxic: danger of serious damage to health by prolonged exposure in contact with skin. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par contact avec la  peau. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata a contatto con  la pelle. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  aanraking met de huid. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada em contacto com a  pele. R 48/25 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por ingestión. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved indtagelse. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Verschlucken. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa ðaañssðôùóç  êáôáðueóaaùò. EN: Toxic: danger of serious damage to health by prolonged exposure if swallowed. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par ingestion. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata per ingestione. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  opname door de mond. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada por ingestão.  R 48/23/24 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación  y contacto con la piel. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding og hudkontakt. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen und durch  Beruehrung mit der Haut. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé êáé  óaa aaðáoeÞ ìaa ôï aeÝñìá. EN: Toxic: danger of serious damage to health by prolonged exposure through inhalation and in  contact with skin. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation et  par contact avec la peau. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione e  a contatto con la pelle. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing en aanraking met de huid. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação e em  contacto com a pele. R 48/23/25 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación  e ingestión. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding og indtagelse. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen und durch  Verschlucken. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé êáé  óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of serious damage to health by prolonged exposure through inhalation and if  swallowed. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation et  par ingestion. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione  ed ingestione. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing en opname door de mond. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação e  ingestão. R 48/24/25 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por contacto  con la piel e ingestión. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved hudkontakt og indtagelse. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Beruehrung mit der Haut  und durch Verschlucken. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç óaa aaðáoeÞ ìaa ôï aeÝñìá  êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of serious damage to health by prolonged exposure in contact with skin and if  swallowed. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par contact avec la  peau et par ingestion. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata a contatto con  la pelle e per ingestione. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  aanraking met de huid en opname door de mond. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada em contacto com a  pele e por ingestão. R 48/23/24/25 ES: Tóxico: riesgo de efectos graves para la salud en caso de exposición prolongada por inhalación,  contacto con la piel e ingestión. DA: Giftig: alvorlig sundhedsfare ved laengere tids paavirkning ved indaanding, hudkontakt og  indtagelse. DE: Giftig: Gefahr ernster Gesundheitsschaeden bei laengerer Exposition durch Einatmen, Beruehrung mit  der Haut und durch Verschlucken. EL: Ôïîéêue: êssíaeõíïò óïâáñÞò âëUEâçò ôçò õãaassáò ýóôaañá áðue ðáñáôaaôáìÝíç Ýêèaaóç ueôáí aaéóðíÝaaôáé, óaa  aaðáoeÞ ìaa ôï aeÝñìá êáé óaa ðaañssðôùóç êáôáðueóaaùò. EN: Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact  with skin and if swallowed. FR: Toxique: risque d'effets graves pour la santé en cas d'exposition prolongée par inhalation, par  contact avec la peau et par ingestion. IT: Tossico: pericolo di gravi danni alla salute in caso di esposizione prolungata per inalazione,  a contatto con la pelle e per ingestione. NL: Vergiftig: gevaar voor ernstige schade aan de gezondheid bij langdurige blootstelling bij  inademing, aanraking met de huid en opname door de mond. PT: Tóxico: risco de efeitos graves para a saúde em caso de exposição prolongada por inalação, em  contacto com a pele e por ingestão. R 50/53 ES: Muy tóxico para los organismos acuáticos, puede provocar a largo plazo efectos negativos en el  medio ambiente acuático. DA: Meget giftig for organismer, der lever i vand; kan foraarsage uoenskede langtidsvirkninger i  vandmiljoeet. DE: Sehr giftig fuer Wasserorganismen, kann in Gewaessern laengerfristig schaedliche Wirkungen haben. EL: Ðïëý ôïîéêue ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò, ìðïñaass íá ðñïêáëÝóaaé ìáêñï÷ñueíéaaò aeõóìaaíaassò  aaðéðôþóaaéò óôï õaeUEôéíï ðaañéâUEëëïí. EN: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic  environment. FR: Très toxique pour les organismes aquatiques, peut entraîner des effets néfastes à long terme  pour l'environnement aquatique. IT: Altamente tossico per gli organismi acquatici, può provocare a lungo termine effetti negativi  per l'ambiente acquatico. NL: Zeer vergiftig voor in het water levende organismen; kan in het aquatisch milieu op lange  termijn schadelijke effecten veroorzaken. PT: Muito tóxico para os organismos aquáticos, podendo causar efeitos nefastos a longo prazo no  ambiente aquático. R 51/53 ES: Tóxico para los organismos acuáticos, puede provocar a largo plazo efectos negativos en el  medio ambiente acuático. DA: Giftig for organismer, der lever i vand; kan foraarsage uoenskede langtidsvirkninger i  vandmiljoeet. DE: Giftig fuer Wasserorganismen, kann in Gewaessern laengerfristig schaedliche Wirkungen haben. EL: Ôïîéêue ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò, ìðïñaass íá ðñïêáëÝóaaé ìáêñï÷ñueíéaaò aeõóìaaíaassò aaðéðôþóaaéò  óôï õaeUEôéíï ðaañéâUEëëïí. EN: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. FR: Toxique pour les organismes aquatiques, peut entraîner des effets néfastes à long terme pour  l'environnement aquatique. IT: Tossico per gli organismi acquatici, può provocare a lungo termine effetti negativi per  l'ambiente acquatico. NL: Vergiftig voor in het water levende organismen; kan in het aquatisch milieu op lange termijn  schadelijke effecten veroorzaken. PT: Tóxico para os organismos aquáticos, podendo causar efeitos nefastos a longo prazo no ambiente  aquático. R 52/53 ES: Nocivo para los organismos acuáticos, puede provocar a largo plazo efectos negativos en el  medio ambiente acuático. DA: Skadelig for organismer, der lever i vand; kan foraarsage uoenskede langtidsvirkninger i  vandmiljoeet. DE: Schaedlich fuer Wasserorganismen, kann in Gewaessern laengerfristig schaedliche Wirkungen haben. EL: AAðéâëáâÝò ãéá ôïõò õaeñueâéïõò ïñãáíéóìïýò, ìðïñaass íá ðñïêáëÝóaaé ìáêñï÷ñueíéaaò aeõóìaaíaassò  aaðéðôþóaaéò óôï õaeUEôéíï ðaañéâUEëëïí. EN: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. FR: Nocif pour les organismes aquatiques, peut entraîner des effets néfastes à long terme pour  l'environnement aquatique. IT: Nocivo per gli organismi acquatici, può provocare a lungo termine effetti negativi per  l'ambiente acquatico. NL: Schadelijk voor in het water levende organismen; kan in het aquatisch milieu op lange termijn  schadelijke effecten veroorzaken. PT: Nocivo para os organismos aquáticos, podendo causar efeitos nefastos a longo prazo no ambiente  aquático.   ANEXO III - BILAG III - ANHANG III - ÐÁÑÁÑÔÇÌÁ ÉÉÉ - ANNEX III - ANNEXE III - ALLEGATO III  - BIJLAGE III - ANEXO III ANEXO IV Consejos de prudencia relativos a las sustancias y  preparados peligrosos BILAG IV Forsigtighedsregler for farlige stoffer og praeparater ANHANG  IV Sicherheitsratschlaege fuer gefaehrliche Stoffe und Zubereitungen ÐÁÑÁÑÔÇÌÁ IV Ïaeçãssaaò  áóoeáëïýò ÷ñÞóçò ðïõ áoeïñïýí aaðéêssíaeõíaaò ÷çìéêÝò ïõóssaaò êáé ðáñáóêaaõUEóìáôá ANNEX IV Safety  advice concerning dangerous substances and preparations ANNEXE IV Conseils de prudence  concernant les substances et préparations dangereuses ALLEGATO IV Consigli di prudenza  riguardanti le sostanze e preparati pericolosi BIJLAGE IV Veiligheidsaanbevelingen met  betrekking tot gevaarlijke stoffen en preparaten ANEXO IV Conselhos de prudência relativos a  substâncias e preparações perigosas S 1 ES: Consérvese bajo llave. DA: Opbevares under laas. DE: Unter Verschluss aufbewahren. EL: Íá oeõëUEóóaaôáé êëaaéaeùìÝíï. EN: Keep locked up. FR: Conserver sous clé. IT: Conservare sotto chiave. NL: Achter slot bewaren. PT: Guardar fechado à chave. S 2 ES: Manténgase fuera del alcance de los niños. DA: Opbevares utilgaengeligt for boern. DE: Darf nicht in die Haende von Kindern gelangen. EL: ÌáêñõUE áðue ðáéaeéUE. EN: Keep out of the reach of children. FR: Conserver hors de la portée des enfants. IT: Conservare fuori della portata dei bambini. NL: Buiten bereik van kinderen bewaren. PT: Manter fora do alcance das crianças. S 3 ES: Consérvese en lugar fresco. DA: Opbevares koeligt. DE: Kuehl aufbewahren. EL: Íá oeõëUEóóaaôáé óaa aeñïóaañue ìÝñïò. EN: Keep in a cool place. FR: Conserver dans un endroit frais. IT: Conservare in luogo fresco. NL: Op een koele plaats bewaren. PT: Guardar em lugar fresco. S 4 ES: Manténgase lejos de locales habitados. DA: Maa ikke opbevares i naerheden af beboelse. DE: Von Wohnplaetzen fernhalten. EL: ÌáêñõUE áðue êáôïéêçìÝíïõò ÷þñïõò. EN: Keep away from living quarters. FR: Conserver à l'écart de tout local d'habitation. IT: Conservare lontano da locali di abitazione. NL: Verwijderd van woonruimten opbergen. PT: Manter fora de qualquer zona de habitação. S 5 ES: Consérvese en .  .  . (líquido apropiado a especificar por el fabricante). DA: Opbevares under .  .  . (en egnet vaeske, som angives af fabikanten). DE: Unter .  .  . aufbewahren (geeignete Fluessigkeit vom Hersteller anzugeben). EL: Íá aeéáôçñaassôáé ôï ðaañéaa÷ueìaaíï ìÝóá óaa .  .  . (ôï aassaeïò ôïõ êáôUEëëçëïõ õãñïý êáèïñssaeaaôáé áðue  ôïí ðáñáãùãue). EN: Keep contents under .  .  . (appropriate liquid to be specified by the manufacturer). FR: Conserver sous .  .  . (liquide approprié à spécifier par le fabricant). IT: Conservare sotto .  .  . (liquido appropriato da indicarsi da parte del fabbricante). NL: Onder .  .  . houden. [geschikte vloeistof aan te geven door fabrikant]. PT: Manter sob .  .  . (líquido apropriado a especificar pelo produtor). S 6 ES: Consérvese en .  .  . (gas inerte a especificar por el fabricante). DA: Opbevares under .  .  . (en inaktiv gas, som angives af fabrikanten). DE: Unter .  .  . aufbewahren (inertes Gas vom Hersteller anzugeben). EL: Íá aeéáôçñaassôáé óaa áôìueóoeáéñá .  .  . (ôï aassaeïò ôïõ áaeñáíïýò áaañssïõ êáèïñssaeaaôáé áðue ôïí  ðáñáãùãue). EN: Keep under .  .  . (inert gas to be specified by the manufacturer). FR: Conserver sous .  .  . (gaz inerte à spécifier par le fabricant). IT: Conservare sotto .  .  . (gas inerte da indicarsi da parte del fabbricante). NL: Onder .  .  . houden. [inert gas aan te geven door fabrikant]. PT: Manter sob .  .  . (gás inerte a especificar pelo produtor). S 7 ES: Manténgase el recipiente bien cerrado. DA: Emballagen skal holdes taet lukket. DE: Behaelter dicht geschlossen halten. EL: Ôï aeï÷aassï íá aeéáôçñaassôáé aañìçôéêUE êëaaéóìÝíï. EN: Keep container tightly closed. FR: Conserver le récipient bien fermé. IT: Conservare il recipiente ben chiuso. NL: In goed gesloten verpakking bewaren. PT: Manter o recipiente bem fechado. S 8 ES: Manténgase el recipiente en lugar seco. DA: Emballagen skal opbevares toert. DE: Behaelter trocken halten. EL: Ôï aeï÷aassï íá ðñïóôáôaaýaaôáé áðue ôçí õãñáóssá. EN: Keep container dry. FR: Conserver le récipient à l'abri de l'humidité. IT: Conservare al riparo dall'umidità. NL: Verpakking droog houden. PT: Manter o recipiente ao abrigo da humidade. S 9 ES: Consérvese el recipiente en lugar bien ventilado. DA: Emballagen skal opbevares paa et godt ventileret sted. DE: Behaelter an einem gut geluefteten Ort aufbewahren. EL: Ôï aeï÷aassï íá aeéáôçñaassôáé óaa êáëUE áaañéaeueìaaíï ìÝñïò. EN: Keep container in a well-ventilated place. FR: Conserver le récipient dans un endroit bien ventilé. IT: Conservare il recipiente in luogo ben ventilato. NL: Op een goed geventileerde plaats bewaren. PT: Manter o recipiente num local bem ventilado. S 12 ES: No cerrar el recipiente herméticamente. DA: Emballagen maa ikke lukkes taet. DE: Behaelter nicht gasdicht verschliessen. EL: Ìç aeéáôçñaassôaa ôï aeï÷aassï aañìçôéêUE êëaaéóìÝíï. EN: Do not keep the container sealed. FR: Ne pas fermer hermétiquement le récipient. IT: Non chiudere ermeticamente il recipiente. NL: De verpakking niet hermetisch sluiten. PT: Não fechar o recipiente hermeticamente. S 13 ES: Manténgase lejos de alimentos, bebidas y piensos. DA: Maa ikke opbevares sammen med naerings- og nydelsesmidler samt foderstoffer. DE: Von Nahrungsmitteln, Getraenken und Futtermitteln fernhalten. EL: ÌáêñõUE áðue ôñueoeéìá, ðïôUE êáé aeùïôñïoeÝò. EN: Keep away from food, drink and animal feedingstuffs. FR: Conserver à l'écart des aliments et boissons, y compris ceux pour animaux. IT: Conservare lontano da alimenti o mangimi e da bevande. NL: Verwijderd houden van eet- en drinkwaren en van diervoeder. PT: Manter afastado de alimentos e bebidas incluindo os dos animais. S 14 ES: Consérvese lejos de .  .  . (materiales incompatibles a especificar por el fabricante). DA: Opbevares adskilt fra .  .  . (uforligelige stoffer, som angives af fabrikanten). DE: Von .  .  . fernhalten (inkompatible Substanzen sind vom Hersteller anzugeben). EL: ÌáêñõUE áðue .  .  . (áóýìâáôaaò ïõóssaaò êáèïñssaeïíôáé áðue ôïí ðáñáãùãue). EN: Keep away from .  .  . (incompatible materials to be indicated by the manufacturer). FR: Conserver à l'écart des .  .  . (matières incompatibles à indiquer par le fabricant). IT: Conservare lontano da .  .  . (sostanze incompatibili da precisare da parte del produttore). NL: Verwijderd houden van .  .  . [stoffen waarmee contact vermeden dient te worden aan te geven  door de fabrikant]. PT: Manter ao abrigo de .  .  . (matérias incompatíveis a indicar pelo produtor). S 15 ES: Conservar alejado del calor. DA: Maa ikke udsaettes for varme. DE: Vor Hitze schuetzen. EL: ÌáêñõUE áðue èaañìueôçôá. EN: Keep away from heat. FR: Conserver à l'écart de la chaleur. IT: Conservare lontano dal calore. NL: Verwijderd houden van warmte. PT: Manter afastado do calor. S 16 ES: Conservar alejado de toda llama o fuente de chispas - No fumar. DA: Holdes vaek fra antaendelseskilder - Rygning forbudt. DE: Von Zuendquellen fernhalten - Nicht rauchen. EL: ÌáêñõUE áðue ðçãÝò áíUEoeëaaîçò - Áðáãïñaaýaaôáé ôï êUEðíéóìá. EN: Keep away from sources of ignition - No smoking. FR: Conserver à l'écart de toute flamme ou source d'étincelles - Ne pas fumer. IT: Conservare lontano da fiamme e scintille - Non fumare. NL: Verwijderd houden van ontstekingsbronnen - Niet roken. PT: Manter afastado de qualquer chama ou fonte de faísca - Não fumar. S 17 ES: Manténgase lejos de materias combustibles. DA: Holdes vaek fra braendbare stoffer. DE: Von brennbaren Stoffen fernhalten. EL: ÌáêñõUE áðue êáýóéìá õëéêUE. EN: Keep away from combustible material. FR: Tenir à l'écart des matières combustibles. IT: Tenere lontano da sostanze combustibili. NL: Verwijderd houden van brandbare stoffen. PT: Manter afastado de matérias combustíveis. S 18 ES: Manipúlese y ábrase el recipiente con prudencia. DA: Emballagen skal behandles og aabnes med forsigtighed. DE: Behaelter mit Vorsicht oeffnen und handhaben. EL: ×aaéñéóôaassôaa êáé áíïssîôaa ôï aeï÷aassï ðñïóaaêôéêUE. EN: Handle and open container with care. FR: Manipuler et ouvrir le récipient avec prudence. IT: Manipolare ed aprire il recipiente con cautela. NL: Verpakking voorzichtig behandelen en openen. PT: Manipular e abrir o recipiente com prudência. S 20 ES: No comer ni beber durante su utilización. DA: Der maa ikke spises eller drikkes under brugen. DE: Bei der Arbeit nicht essen und trinken. EL: Ìç ôñþôaa Þ ðssíaaôaa ueôáí ôï ÷ñçóéìïðïéaassôaa. EN: When using do not eat or drink. FR: Ne pas manger et ne pas boire pendant l'utilisation. IT: Non mangiare né bere durante l'impiego. NL: Niet eten of drinken tijdens gebruik. PT: Não comer nem beber durante a utilização. S 21 ES: No fumar durante su utilización. DA: Der maa ikke ryges under brugen. DE: Bei der Arbeit nicht rauchen. EL: Ìç êáðíssaeaaôaa ueôáí ôï ÷ñçóéìïðïéaassôaa. EN: When using do not smoke. FR: Ne pas fumer pendant l'utilisation. IT: Non fumare durante l'impiego. NL: Niet roken tijdens gebruik. PT: Não fumar durante a utilização. S 22 ES: No respirar el polvo. DA: Undgaa indaanding af stoev. DE: Staub nicht einatmen. EL: Ìç áíáðíÝaaôaa ôçí óêueíç. EN: Do not breathe dust. FR: Ne pas respirer les poussières. IT: Non respirare le polveri. NL: Stof niet inademen. PT: Não respirar as poeiras. S 23 ES: No respirar los gases/humos/vapores/aerosoles [denominación(es) adecuada(s) a especificar por  el fabricante]. DA: Undgaa indaanding af gas/roeg/dampe/aerosol-taager (den eller de paagaeldende betegnelser angives af  fabrikanten). DE: Gas/Rauch/Dampf/Aerosol nicht einatmen (geeignete Bezeichnung(en) vom Hersteller anzugeben). EL: Ìçí áíáðíÝaaôaa áÝñéá/áíáèõìéUEóaaéò/áôìïýò/aaêíaaoeþìáôá (ç êáôUEëëçëç aeéáôýðùóç êáèïñssaeaaôáé áðue ôïí  ðáñáãùãue). EN: Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the  manufacturer). FR: Ne pas respirer les gaz/vapeurs/fumées/aérosols [terme(s) approprié(s) à indiquer par le  fabricant]. IT: Non respirare i gas/fumi/vapori/aerosoli [termine(i) appropriato(i) da precisare da parte del  produttore]. NL: Gas/rook/damp/spuitnevel niet inademen. [toepasselijke term(en) aan te geven door de  fabrikant]. PT: Não respirar os gases/vapores/fumos/aerossóis [termo(s) apropriado(s) a indicar pelo  produtor]. S 24 ES: Evítese el contacto con la piel. DA: Undgaa kontakt med huden. DE: Beruehrung mit der Haut vermeiden. EL: Áðïoeaaýãaaôaa ôçí aaðáoeÞ ìaa ôï aeÝñìá. EN: Avoid contact with skin. FR: Éviter le contact avec la peau. IT: Evitare il contatto con la pelle. NL: Aanraking met de huid vermijden. PT: Evitar o contacto com a pele. S 25 ES: Evítese el contacto con los ojos. DA: Undgaa kontakt med oejnene. DE: Beruehrung mit den Augen vermeiden. EL: Áðïoeaaýãaaôaa ôçí aaðáoeÞ ìaa ôá ìUEôéá. EN: Avoid contact with eyes. FR: Éviter le contact avec les yeux. IT: Evitare il contatto con gli occhi. NL: Aanraking met de ogen vermijden. PT: Evitar o contacto com os olhos. S 26 ES: En caso de contacto con los ojos, lávense inmediata y abundantemente con agua y acúdase a un  médico. DA: Kommer stoffet i oejnene, skylles straks grundigt med vand og laege kontaktes. DE: Bei Beruehrung mit den Augen sofort mit Wasser abspuelen und Arzt konsultieren. EL: Óaa ðaañssðôùóç aaðáoeÞò ìaa ôá ìUEôéá ðëýíaaôÝ ôá áìÝóùò ìaa UEoeèïíï íaañue êáé aeçôÞóôaa éáôñéêÞ óõìâïõëÞ. EN: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. FR: En cas de contact avec les yeux, laver immédiatement et abondamment avec de l'eau et consulter  un spécialiste. IT: In caso di contatto con gli occhi, lavare immediatamente e abbondantemente con acqua e  consultare un medico. NL: Bij aanraking met de ogen onmiddellijk met overvloedig water afspoelen en deskundig medisch  advies inwinnen. PT: Em caso de contacto com os olhos, lavar imediata e abundantemente com água e consultar um  especialista.  S 27 ES: Quítese inmediatamente la ropa manchada o salpicada. DA: Tilsmudset toej tages straks af. DE: Beschmutzte, getraenkte Kleidung sofort ausziehen. EL: ÁoeáéñÝóôaa áìÝóùò ueëá ôá aaíaeýìáôá ðïõ Ý÷ïõí ìïëõíèaass. EN: Take off immediately all contaminated clothing. FR: Enlever immédiatement tout vêtement souillé ou éclaboussé. IT: Togliersi di dosso immediatamente gli indumenti contaminati. NL: Verontreinigde kleding onmiddellijk uittrekken. PT: Retirar imediatamente todo o vestuário contaminado. S 28 ES: En caso de contacto con la piel, lávese inmediata y abundantemente con .  .  . (productos a  especificar por el fabricante). DA: Kommer stof paa huden vaskes straks med store maengder .  .  . (angives af fabrikanten). DE: Bei Beruehrung mit der Haut sofort abwaschen mit viel .  .  . (vom Hersteller anzugeben). EL: Óaa ðaañssðôùóç aaðáoeÞò ìaa ôï aeÝñìá, ðëõèaassôaa áìÝóùò ìaa UEoeèïíï .  .  . (ôï aassaeïò ôïõ õãñïý  êáèïñssaeaaôáé áðue ôïí ðáñáãùãue). EN: After contact with skin, wash immediately with plenty of .  .  . (to be specified by the  manufacturer). FR: Après contact avec la peau, se laver immédiatement et abondamment avec .  .  . (produits  appropriés à indiquer par le fabricant). IT: In caso di contatto con la pelle lavarsi immediatamente ed abbondantemente con .  .  .  (prodotti idonei da indicarsi da parte del fabbricante). NL: Na aanraking met de huid onmiddellijk wassen met veel .  .  . [aan te geven door de  fabrikant]. PT: Ápos contacto com a pele, lavar imediata e abundantemente com .  .  . (produtos adequados a  indicar pelo produtor). S 29 ES: No tirar los residuos por el desaguee. DA: Maa ikke kommes i kloakafloeb. DE: Nicht in die Kanalisation gelangen lassen. EL: Ìçí áaeaaéUEaeaaôaa ôï ðaañéaa÷ueìaaíï óôçí áðï÷Ýôaaõóç. EN: Do not empty into drains. FR: Ne pas jeter les résidus à l'égout. IT: Non gettare i residui nelle fognature. NL: Afval niet in de gootsteen werpen. PT: Não deitar os resíduos no esgoto. S 30 ES: No echar jamás agua a este producto. DA: Haeld aldrig vand paa eller i produktet. DE: Niemals Wasser hinzugiessen. EL: ÐïôÝ ìçí ðñïóèÝôaaôaa íaañue óôï ðñïúueí áõôue. EN: Never add water to this product. FR: Ne jamais verser de l'eau dans ce produit. IT: Non versare acqua sul prodotto. NL: Nooit water op deze stof gieten. PT: Nunca adicionar água a este produto. S 33 ES: Evítese la acumulación de cargas electroestáticas. DA: Traef foranstaltninger mod statisk elektricitet. DE: Massnahmen gegen elektrostatische Aufladungen treffen. EL: ËUEâaaôaa ðñïóôáôaaõôéêUE ìÝôñá Ýíáíôé çëaaêôñïóôáôéêþí aaêêaaíþóaaùí. EN: Take precautionary measures against static discharges.FR: Éviter l'accumulation de charges électrostatiques. IT: Evitare l'accumulo di cariche elettrostatiche. NL: Maatregelen treffen tegen ontladingen van statische elektriciteit. PT: Evitar acumulação de cargas electrostáticas. S 35 ES: Elimínense los residuos del producto y sus recipientes con todas las precauciones posibles. DA: Stoffet og emballagen skal bortskaffes paa en sikker maade. DE: Abfaelle und Behaelter muessen in gesicherter Weise beseitigt werden. EL: Ôï õëéêue êáé ï ðaañéÝêôçò ôïõ ðñÝðaaé íá aeéáôaaèaass ìaa áóoeáëÞ ôñueðï. EN: This material and its container must be disposed of in a safe way. FR: Ne se débarrasser de ce produit et de son récipient qu'en prenant toutes précautions d'usage. IT: Non disfarsi del prodotto e del recipiente se non con le dovute precauzioni. NL: Deze stof en de verpakking op veilige wijze afvoeren. PT: Não se desfazer deste produto e do seu recipiente sem tomar as precauções de segurança  devidas. S 36 ES: Úsese indumentaria protectora adecuada. DA: Brug saerligt arbejdstoej. DE: Bei der Arbeit geeignete Schutzkleidung tragen. EL: Íá oeïñUEôaa êáôUEëëçëç ðñïóôáôaaõôéêÞ aaíaeõìáóssá. EN: Wear suitable protective clothing. FR: Porter un vêtement de protection approprié. IT: Usare indumenti protettivi adatti. NL: Draag geschikte beschermende kleding. PT: Usar vestuário de protecção adequado. S 37 ES: Úsense guantes adecuados. DA: Brug egnede beskyttelseshandsker under arbejdet. DE: Geeignete Schutzhandschuhe tragen. EL: Íá oeïñUEôaa êáôUEëëçëá ãUEíôéá. EN: Wear suitable gloves. FR: Porter des gants appropriés. IT: Usare guanti adatti. NL: Draag geschikte handschoenen. PT: Usar luvas adequadas. S 38 ES: En caso de ventilación insuficiente, úsese equipo respiratorio adecuado. DA: Brug egnet aandedraetsvaern, hvis effektiv ventilation ikke er mulig. DE: Bei unzureichender Belueftung Atemschutzgeraet anlegen. EL: Óaa ðaañssðôùóç áíaaðáñêïýò áaañéóìïý, ÷ñçóéìïðïéaassôaa êáôUEëëçëç áíáðíaaõóôéêÞ óõóêaaõÞ. EN: In case of insufficient ventilation, wear suitable respiratory equipment. FR: En cas de ventilation insuffisante, porter un appareil respiratoire approprié. IT: In caso di ventilazione insufficiente, usare un apparecchio respiratorio adatto. NL: Bij ontoereikende ventilatie een geschikte ademhalingsbescherming dragen. PT: Em caso de ventilação insuficiente, usar equipamento respiratório adequado. S 39 ES: Úsese protección para los ojos/la cara. DA: Brug beskyttelsesbriller/ansigtsskaerm under arbejdet. DE: Schutzbrille/Gesichtsschutz tragen. EL: ×ñçóéìïðïéaassôaa óõóêaaõÞ ðñïóôáóssáò ìáôéþí/ðñïóþðïõ. EN: Wear eye/face protection. FR: Porter un appareil de protection des yeux/du visage. IT: Proteggersi gli occhi/la faccia. NL: Een bescherming voor de ogen/voor het gezicht dragen. PT: Usar um equipamento protector para a vista/face. S 40 ES: Para limpiar el suelo y los objetos contaminados por este producto, úsese .  .  . (a  especificar por el fabricante). DA: Gulvet og tilsmudsede genstande renses med .  .  . (midlerne angives af fabrikanten). DE: Fussboden und verunreinigte Gegenstaende mit .  .  . reinigen (Material vom Hersteller  anzugeben). EL: Ãéá ôïí êáèáñéóìue ôïõ aeáðÝaeïõ êáé ueëùí ôùí áíôéêaaéìÝíùí ðïõ Ý÷ïõí ìïëõíèaass áðue ôï õëéêue áõôue  ÷ñçóéìïðïéaassôaa .  .  . (ôï aassaeïò êáèïñssaeaaôáé áðue ôïí ðáñáãùãue). EN: To clean the floor and all objects contaminated by this material, use .  .  . (to be specified  by the manufacturer). FR: Pour nettoyer le sol ou les objets souillés par ce produit, utiliser .  .  . (à préciser par le  fabricant). IT: Per pulire il pavimento e gli oggetti contaminati da questo prodotto, usare .  .  . (da  precisare da parte del produttore). NL: Voor de reiniging van de vloer en alle voorwerpen verontreinigd met dit materiaal, .  .  .  gebruiken. [aan te geven door de fabrikant]. PT: Para limpeza do chão e objectos contaminados por este produto, utilizar .  .  . (a especificar  pelo produtor). S 41 ES: En caso de incendio y/o de explosión no respire los humos. DA: Undgaa at indaande roegen ved brand eller eksplosion. DE: Explosions- und Brandgase nicht einatmen. EL: Óaa ðaañssðôùóç ðõñêáãéUEò êáé/Þ aaêñÞîaaùò ìçí áíáðíÝaaôaa ôïõò êáðíïýò. EN: In case of fire and/or explosion do not breathe fumes. FR: En cas d'incendie et/ou d'explosion, ne pas respirer les fumées. IT: In caso di incendio e/o esplosione non respirare i fumi. Nl: In geval van brand en/of explosie inademen van rook vermijden. PT: Em caso de incêndio e/ou explosão não respirar os fumos. S 42 ES: Durante las fumigaciones/pulverizaciones, úsese equipo respiratorio adecuado [denominación(es)  adecuada(s) a especificar por el fabricante]. DA: Brug egnet aandedraetsvaern ved rygning/sproejtning (den eller de paagaeldende betegnelser angives af  fabrikanten). DE: Beim Raeuchern/Verspruehen geeignetes Atemschutzgeraet anlegen (geeignete Bezeichnung(en) vom  Hersteller anzugeben). EL: ÊáôUE ôç aeéUEñêaaéá õðïêáðíéóìïý/oeaaêUEóìáôïò ÷ñçóéìïðïéaassôaa êáôUEëëçëç áíáðíaaõóôéêÞ óõóêaaõÞ (ç  êáôUEëëçëç aeéáôýðùóç êáèïñssaeaaôáé áðï ôïí ðáñáãùãue). EN: During fumigation/spraying wear suitable respiratory equipment (appropriate wording to be  specified by the manufacturer). FR: Pendant les fumigations/pulvérisations, porter un appareil respiratoire approprié [terme(s)  approprié(s) à indiquer par le fabricant]. IT: Durante le fumigazioni/polimerizzazioni usare un apparecchio respiratorio adatto [termine(i)  appropriato(i) da precisare da parte del produttore]. NL: Tijdens de ontsmetting/bespuiting een geschikte adembescherming dragen. [geschikte term(en)  door de fabrikant aan te geven]. PT: Durante as fumigações/pulverizações usar equipamento respiratório adequado [termo(s)  adequado(s) a indicar pelo produtor]. S 43 ES: En caso de incendio, utilizar .  .  . (los medios de extinción los debe especificar el  fabricante). (Si el agua aumenta el riesgo, se deberá añadir: «  No usar nunca agua.  ») DA: Brug .  .  . ved brandslukning (den noejagtige type brandslukningsudstyr angives af fabrikanten.  Saafremt vand ikke maa bruges tilfoejes: »Brug ikke vand«). DE: Zum Loeschen .  .  . (vom Hersteller anzugeben) verwenden (wenn Wasser die Gefahr erhoeht,  anfuegen: "Kein Wasser verwenden"). EL: Óaa ðaañssðôùóç ðõñêáãéUEò ÷ñçóéìïðïéaassôaa .  .  . (ÁíáoeÝñaaôáé ôï áêñéâÝò aassaeïò ìÝóùí ðõñueóâaaóçò.  AAUEí ôï íaañue áõîUEíaaé ôïí êssíaeõíï, ðñïóôssèaaôáé: «Ìç ÷ñçóéìïðïéaassôaa ðïôÝ íaañue»). EN: In case of fire, use .  .  . (indicate in the space the precise type of fire-fighting  equipment. If water increases risk, add - 'Never use water`). FR: En cas d'incendie, utiliser .  .  . (moyens d'extinction à préciser par le fabricant. Si l'eau  augmente les risques, ajouter: «  Ne jamais utiliser d'eau  »). IT: In caso di incendio usare .  .  . (mezzi estinguenti idonei da indicarsi da parte del  fabbricante. Se l'acqua aumenta il rischio precisare «  Non usare acqua  »). NL: In geval van brand .  .  . gebruiken. [blusmiddelen aan te duiden door de fabrikant. Indien  water het risico vergroot toevoegen: "Nooit water gebruiken."] PT: Em caso de incêndio, utilizar .  .  . (meios de extinção a especificar pelo produtor. Se a água  aumentar os riscos, acrescentar «  Nunca utilizar água  »). S 45 ES: En caso de accidente o malestar, acúdase inmediatamente al médico (si es posible, muéstresele  la etiqueta). DA: Ved ulykkestilfaelde eller ved ildebefindende er omgaaende laegebehandling noedvendig; vis  etiketten, hvis det er muligt. DE: Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn moeglich, dieses Etikett vorzeigen). EL: Óaa ðaañssðôùóç áôõ÷Þìáôïò Þ áí áéóèáíèaassôaa áaeéáèaaóssá aeçôÞóôaa áìÝóùò éáôñéêÞ óõìâïõëÞ (aeaassîôaa ôçí  aaôéêÝôôá áí aassíáé aeõíáôue). EN: In case of accident or if you feel unwell, seek medical advice immediately (show the label  where possible). FR: En cas d'accident ou de malaise, consulter immédiatement un médecin (si possible lui montrer  l'étiquette). IT: In caso di incidente o di malessere consultare immediatamente il medico (se possibile,  mostrargli l'etichetta). NL: Bij een ongeval of indien men zich onwel voelt, onmiddellijk een arts raadplegen (indien  mogelijk hem dit etiket tonen). PT: Em caso de acidente ou de indisposição, consultar imediatamente o médico (se possível  mostrar-lhe o rótulo). S 46 ES: En caso de ingestión, acúdase inmediatamente al médico y muéstresele la etiqueta o el envase. DA: Ved indtagelse, kontakt omgaaende laege og vis denne beholder eller etiket. DE: Bei Verschlucken sofort aerztlichen Rat einholen und Verpackung oder Etikett vorzeigen. EL: Óaa ðaañssðôùóç êáôUEðïóçò aeçôÞóôaa áìÝóùò éáôñéêÞ óõìâïõëÞ êáé aeaassîôaa áõôue ôï aeï÷aassï Þ ôçí  aaôéêÝôôá. EN: If swallowed, seek medical advice immediately and show this container or label. FR: En cas d'ingestion, consulter immédiatement un médecin et lui montrer l'emballage ou  l'étiquette. IT: In caso d'ingestione consultare immediatamente il medico e mostrargli il contenitore o  l'etichetta. NL: In geval van inslikken onmiddellijk een arts raadplegen en verpakking of etiket tonen. PT: Em caso de ingestão, consultar imediatamente o médico e mostrar-lhe a embalagem ou o rótulo. S 47 ES: Consérvese a una temperatura no superior a .  .  .  °C (a especificar por el fabricante). DA: Maa ikke opbevares ved temperaturer paa over .  .  .  °C (angives af fabrikanten). DE: Nicht bei Temperaturen ueber .  .  .  °C aufbewahren (vom Hersteller anzugeben). EL: Íá aeéáôçñaassôáé óaa èaañìïêñáóssá ðïõ aeaaí õðaañâássíaaé ôïõò .  .  .  °C (êáèïñssaeaaôáé áðue ôïí  ðáñáãùãue). EN: Keep at temperature not exceeding .  .  .  °C (to be specified by the manufacturer). FR: Conserver à une température ne dépassant pas .  .  .  °C (à préciser par le fabricant). IT: Conservare a temperatura non superiore a .  .  .  °C (da precisare da parte del fabbricante). NL: Bewaren bij een temperatuur beneden .  .  .  °C. [aan te geven door de fabrikant]. PT: Conservar a uma temperatura que não exceda .  .  .  °C (a especificar pelo produtor). S 48 ES: Consérvese húmedo con .  .  . (medio apropiado a especificar por el fabricante). DA: Holdes befugtet med .  .  . (passende middel angives af fabrikanten). DE: Feucht halten mit .  .  . (geeignetes Mittel vom Hersteller anzugeben). EL: Íá aeéáôçñaassôáé õãñue ìaa .  .  . (êáôUEëëçëï õãñue ðïõ ðñÝðaaé íá êáèïñéóôaass áðue ôïí ðáñáãùãue). EN: Keep wet with .  .  . (appropriate material to be specified by the manufacturer). FR: Maintenir humide avec .  .  . (moyen approprié à préciser par le fabricant). IT: Mantenere umido con .  .  . (mezzo appropriato da precisare da parte del fabbricante). NL: Inhoud vochtig houden met .  .  . [middel aan te geven door de fabrikant]. PT: Manter húmido com .  .  . (material adequado a especificar pelo produtor).  S 49 ES: Consérvese únicamente en el recipiente de origen. DA: Maa kun opbevares i den originale emballage. DE: Nur im Originalbehaelter aufbewahren. EL: AEéáôçñaassôáé ìueíï ìÝóá óôï áñ÷éêue aeï÷aassï. EN: Keep only in the original container. FR: Conserver uniquement dans le récipient d'origine. IT: Conservare soltanto nel recipiente originale. NL: Uitsluitend in de oorspronkelijke verpakking bewaren. PT: Conservar unicamente no recipiente de origem. S 50 ES: No mezclar con .  .  . (a especificar por el fabricante). DA: Maa ikke blandes med .  .  . (angives af fabrikanten). DE: Nicht mischen mit .  .  . (vom Hersteller anzugeben). EL: Íá ìçí áíáìé÷èaass ìaa .  .  . (êáèïñssaeaaôáé áðue ôïí ðáñáãùãue). EN: Do not mix with .  .  . (to be specified by the manufacturer). FR: Ne pas mélanger avec .  .  . (à spécifier par le fabricant). IT: Non mescolare con .  .  . (da specificare da parte del fabbricante). NL: Niet vermengen met .  .  . [aan te geven door de fabrikant]. PT: Não misturar com .  .  . (a especificar pelo produtor). S 51 ES: Úsese únicamente en lugares bien ventilados. DA: Maa kun bruges paa steder med god ventilation. DE: Nur in gut geluefteten Bereichen verwenden. EL: Íá ÷ñçóéìïðïéaassôáé ìueíï óaa êáëUE áaañéaeueìaaíï ÷þñï. EN: Use only in well-ventilated areas. FR: Utiliser seulement dans des zones bien ventilées. IT: Usare soltanto in luogo ben ventilato. NL: Uitsluitend op goed geventileerde plaatsen gebruiken. PT: Utilizar somente em locais bem ventilados. S 52 ES: No usar sobre grandes superficies en locales habitados. DA: Boer ikke anvendes til stoerre flader i beboelses- eller opholdsrum. DE: Nicht grossflaechig fuer Wohn- und Aufenthaltsraeume zu verwenden. EL: AEaaí óõíssóôáôáé ç ÷ñÞóç óaa aaõñaassaaò aaðéoeUEíaaéaaò óaa aaóùôaañéêïýò ÷þñïõò. EN: Not recommended for interior use on large surface areas. FR: Ne pas utiliser sur de grandes surfaces dans les locaux habités. IT: Non utilizzare su grandi superfici in locali abitati. NL: Niet voor gebruik op grote oppervlakken in woon- en verblijfruimtes. PT: Não utilizar em grandes superfícies nos locais habitados. S 53 ES: Evítese la exposición - recábense instrucciones especiales antes del uso. DA: Undgaa enhver kontakt - indhent saerlige anvisninger foer brug. DE: Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen. EL: Áðïoeaaýãaaôaa ôçí Ýêèaaóç - aaoeïaeéáóôaassôaa ìaa ôéò aaéaeéêÝò ïaeçãssaaò ðñéí áðue ôç ÷ñÞóç. EN: Avoid exposure - obtain special instructions before use. FR: Éviter l'exposition - se procurer des instructions spéciales avant l'utilisation. IT: Evitare l'esposizione - procurarsi speciali istruzioni prima dell'uso. NL: Blootstelling vermijden - vóór gebruik speciale aanwijzingen raadplegen. PT: Evitar a exposição - obter instruções específicas antes da utilização. S 56 ES: Elimínense esta sustancia y su recipiente en un punto de recogida pública de residuos  especiales o peligrosos. DA: Aflever dette materiale og dets beholder til et indsamlingssted for farligt affald og  problemaffald. DE: Diesen Stoff und seinen Behaelter auf entsprechend genehmigter Sondermuelldeponie entsorgen. EL: Ôï õëéêue áõôue êáé ï ðaañéÝêôçò ôïõ íá aaíáðïôaaèïýí óaa ÷þñï óõëëïãÞò aaðéêéíaeýíùí Þ aaéaeéêþí  áðïâëÞôùí. EN: Dispose of this material and its container at hazardous or special waste collection point. FR: Éliminer ce produit et son récipient dans un centre de collecte des déchets dangereux ou  spéciaux. IT: Smaltire questo materiale e relativi contenitori in un punto di raccolta rifiuti pericolosi o  speciali autorizzati. NL: Deze stof en de verpakking naar inzamelpunt voor gevaarlijk of bijzonder afval brengen. PT: Eliminar este produto e o seu recipiente, enviando-os para local autorizado para a recolha de  resíduos perigosos ou especiais. S 57 ES: Utilícese un envase de seguridad adecuado para evitar la contaminación del medio ambiente. DA: Skal indesluttes forsvarligt for at undgaa miljoeforurening. DE: Zur Vermeidung einer Kontamination der Umwelt geeigneten Behaelter verwenden. EL: Íá ÷ñçóéìïðïéçèaass ôï êáôUEëëçëï ðaañssâëçìá ãéá íá áðïoeaaõ÷èaass ìueëõíóç ôïõ ðaañéâUEëëïíôïò. EN: Use appropriate container to avoid environmental contamination. FR: Utiliser un récipient approprié pour éviter toute contamination du milieu ambiant. IT: Usare contenitori adeguati per evitare l'inquinamento ambientale. NL: Neem passende maatregelen om verspreiding in het milieu te voorkomen. PT: Utilizar um recipiente adequado para evitar a contaminação do ambiente. S 59 ES: Remitirse al fabricante o proveedor para obtener información sobre su recuperación/reciclado. DA: Indhent oplysninger om genvinding/genanvendelse hos fabrikanten/leverandoeren. DE: Informationen zur Wiederverwendung/Wiederverwertung beim Hersteller/Lieferanten erfragen. EL: AEçôÞóôaa ðëçñïoeïñssaaò áðue ôïí ðáñáãùãue/ðñïìçèaaõôÞ ãéá áíUEêôçóç/áíáêýêëùóç. EN: Refer to manufacturer/supplier for information on recovery/recycling. FR: Consulter le fabricant/fournisseur pour des informations relatives à la récupération/au  recyclage. IT: Richiedere informazioni al produttore/fornitore per il recupero/riciclaggio. NL: Raadpleeg fabrikant/leverancier voor informatie over terugwinning/recycling. PT: Solicitar ao produtor/fornecedor informações relativas à sua recuperação/reciclagem. S 60 ES: Elimínense el producto y su recipiente como residuos peligrosos. DA: Dette materiale og dets beholder skal bortskaffes som farligt affald. DE: Dieser Stoff und sein Behaelter sind als gefaehrlicher Abfall zu entsorgen. EL: Ôï õëéêue êáé ï ðaañéÝêôçò ôïõ íá èaaùñçèïýí êáôUE ôç aeéUEèaaóç ôïõò aaðéêssíaeõíá áðueâëçôá. EN: This material and its container must be disposed of as hazardous waste. FR: Éliminer le produit et son récipient comme un déchet dangereux. IT: Questo materiale e il suo contenitore devono essere smaltiti come rifiuti pericolosi. NL: Deze stof en de verpakking als gevaarlijk afval afvoeren. PT: Este produto e o seu recipiente devem ser eliminados como resíduos perigosos. S 61 ES: Evítese su liberación al medio ambiente. Recábense instrucciones específicas de la ficha de  datos de seguridad. DA: Undgaa udledning til miljoeet. Se saerlig vejledning/sikkerhedsdatablad. DE: Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu  Rate ziehen. EL: Áðïoeýãaaôaa ôçí aaëaaõèÝñùóÞ ôïõ óôï ðaañéâUEëëïí. Áíáoeaañèaassôaa óaa aaéaeéêÝò ïaeçãssaaò/aeaaëôssï aeaaaeïìÝíïõ  áóoeáëaassáò. EN: Avoid release to the environment. Refer to special instructions/Safety data sheets. FR: Éviter le rejet dans l'environnement. Consulter les instructions spéciales/la fiche de données  de sécurité. IT: Non disperdere nell'ambiente. Riferirsi alle istruzioni speciali/ schede informative in materia  di sicurezza. NL: Voorkom lozing in het milieu. Vraag om speciale instructies/veiligheidskaart. PT: Evitar a libertação para o ambiente. Obter instruções específicas/fichas de segurança. S 62 ES: En caso de ingestión no provocar el vómito: acúdase inmediatamente al médico y muéstresele la  etiqueta o el envase. DA: Ved indtagelse, undgaa at fremprovokere opkastning: kontakt omgaaende laege og vis denne beholder  eller etiket. DE: Bei Verschlucken kein Erbrechen herbeifuehren. Sofort aerztlichen Rat einholen und Verpackung  oder dieses Etikett vorzeigen. EL: Óaa ðaañssðôùóç êáôUEðïóçò íá ìçí ðñïêëçèaass aaìaaôueò: aeçôÞóôaa áìÝóùò éáôñéêÞ óõìâïõëÞ êáé aeaassîôaa áõôue  ôï aeï÷aassï ç ôçí aaôéêÝôôá ôïõ. EN: If swallowed, do not induce vomiting: seek medical advice immediately and show this container  or label. FR: En cas d'ingestion, ne pas faire vomir: consulter immédiatement un médecin et lui montrer  l'emballage ou l'étiquette. IT: In caso di ingestione non provocare il vomito: consultare immediatamente il medico e mostrargli  il contenitore o l'etichetta. NL: Bij inslikken niet het braken opwekken; direct een arts raadplegen en de verpakking of het  etiket tonen. PT: Em caso de ingestão, não provocar o vómito. Consultar imediatamente um médico e mostrar-lhe a  embalagem ou o rótulo.  Combinación de frases-S Kombination af S-saetninger Kombination der S-Saetze Óõíaeõáóìueò ôùí S-   oeñUEóaaùí Combination of S-phrases Combinaison des phrases S Combinazioni delle frasi S  Combinatie van S-zinnen Combinação das frases S S 1/2 ES: Consérvese bajo llave y manténgase fuera del alcance de los niños. DA: Opbevares under laas og utilgaengeligt for boern. DE: Unter Verschluss und fuer Kinder unzugaenglich aufbewahren. EL: OEõëUEîôaa ôï êëaaéaeùìÝíï êáé ìáêñõUE áðue ðáéaeéUE. EN: Keep locked up and out of the reach of children. FR: Conserver sous clef et hors de portée des enfants. IT: Conservare sotto chiave e fuori della portata dei bambini. NL: Achter slot en buiten bereik van kinderen bewaren. PT: Guardar fechado à chave e fora do alcance das crianças. S 3/7 ES: Consérvese el recipiente bien cerrado y en lugar fresco. DA: Emballagen opbevares taet lukket paa et koeligt sted. DE: Behaelter dicht geschlossen halten und an einem kuehlen Ort aufbewahren. EL: AEéáôçñaassóôaa ôï aeï÷aassï aañìçôéêUE êëaaéóìÝíï óaa aeñïóaañue ìÝñïò. EN: Keep container tightly closed in a cool place. FR: Conserver le récipient bien fermé dans un endroit frais.IT: Tenere il recipiente ben chiuso in luogo fresco. NL: Gesloten verpakking op een koele plaats bewaren. PT: Conservar em recipiente bem fechado em lugar fresco. S 3/9/14 ES: Consérvese en lugar fresco y bien ventilado y lejos de .  .  . (materiales incompatibles, a  especificar por el fabricante). DA: Opbevares koeligt, godt ventileret og adskilt fra .  .  . (uforligelige stoffer angives af  fabrikanten). DE: An einem kuehlen, gut geluefteten Ort, entfernt von .  .  . aufbewahren (die Stoffe, mit denen  Kontakt vermieden werden muss, sind vom Hersteller anzugeben). EL: AEéáôçñaassôáé óaa aeñïóaañue êáé êáëUE áaañéaeueìaaíï ìÝñïò ìáêñõUE áðue .  .  . (áóýìâáôá õëéêUE ðïõ  õðïaeaaéêíýïíôáé áðue ôïí ðáñáãùãue). EN: Keep in a cool, well-ventilated place away from .  .  . (incompatible materials to be indicated  by the manufacturer). FR: Conserver dans un endroit frais et bien ventilé à l'écart des .  .  . (matières incompatibles à  indiquer par le fabricant). IT: Conservare in luogo fresco e ben ventilato lontano da .  .  . (materiali incompatibili da  precisare da parte del fabbricante). NL: Bewaren op een koele, goed geventileerde plaats verwijderd van .  .  . [stoffen waarmee contact  vermeden dient te worden, aan te geven door de fabrikant]. PT: Conservar em lugar fresco e bem ventilado ao abrigo de .  .  . (matérias incompatíveis a  indicar pelo produtor). S 3/9/14/49 ES: Consérvese únicamente en el recipiente de origen, en lugar fresco y bien ventilado y lejos de .   .  . (materiales incompatibles, a especificar por el fabricante). DA: Maa kun opbevares i originalemballagen paa et koeligt, godt ventileret sted og adskilt fra .  .  .  (uforligelige stoffer angives af fabrikanten). DE: Nur im Originalbehaelter an einem kuehlen, gut geluefteten Ort, entfernt von .  .  . aufbewahren  (die Stoffe, mit denen Kontakt vermieden werden muss, sind vom Hersteller anzugeben). EL: AEéáôçñaassôáé ìueíï ìÝóá óôï áñ÷éêue aeï÷aassï óaa aeñïóaañue êáé êáëUE áaañéaeueìaaíï ìÝñïò áðue .  .  .  (áóýìâáôá õëéêUE ðïõ õðïaeaaéêíýïíôáé áðue ôïí ðáñáãùãue). EN: Keep only in the original container in a cool, well-ventilated place away from .  .  .  (incompatible materials to be indicated by the manufacturer). FR: Conserver uniquement dans le récipient d'origine dans un endroit frais et bien ventilé à  l'écart de .  .  . (matières incompatibles à indiquer par le fabricant). IT: Conservare soltanto nel contenitore originale in luogo fresco e ben ventilato lontano da .  .   . (materiali incompatibili da precisare da parte del fabbricante). NL: Uitsluitend in de oorspronkelijke verpakking bewaren op een koele, goed geventileerde plaats  verwijderd van .  .  . [stoffen waarmee contact vermeden dient te worden, aan te geven door de  fabrikant]. PT: Conservar unicamente no recipiente de origem, em lugar fresco e bem ventilado ao abrigo de .  .   . (matérias incompatíveis a indicar pelo produtor). S 3/9/49 ES: Consérvese únicamente en el recipiente de origen, en lugar fresco y bien ventilado. DA: Maa kun opbevares i originalemballagen paa et koeligt, godt ventileret sted. DE: Nur im Originalbehaelter an einem kuehlen, gut geluefteten Ort aufbewahren. EL: AEéáôçñaassôáé ìueíï ìÝóá óôï áñ÷éêue aeï÷aassï óaa aeñïóaañue ìÝñïò. EN: Keep only in the original container in a cool, well-ventilated place. FR: Conserver uniquement dans le récipient d'origine dans un endroit frais et bien ventilé. IT: Conservare soltanto nel contenitore originale in luogo fresco e ben ventilato. NL: Uitsluitend in de oorspronkelijke verpakking bewaren op een koele, goed geventileerde plaats. PT: Conservar unicamente no recipiente de origem, em lugar fresco e bem ventilado. S 3/14 ES: Consérvese en lugar fresco y lejos de .  .  . (materiales incompatibles, a especificar por el  fabricante). DA: Opbevares koeligt og adskilt fra .  .  . (uforligelige stoffer angives af fabrikanten). DE: An einem kuehlen, von .  .  . entfernten Ort aufbewahren (die Stoffe, mit denen Kontakt  vermieden werden muss, sind vom Hersteller anzugeben). EL: AEéáôçñaassôáé óaa aeñïóaañue ìÝñïò ìáêñõUE áðue .  .  . (áóýìâáôá õëéêUE ðïõ õðïaeaaéêíýïíôáé áðue ôïí  ðáñáãùãue). EN: Keep in a cool place away from .  .  . (incompatible materials to be indicated by the  manufacturer). FR: Conserver dans un endroit frais à l'écart des .  .  . (matières incompatibles à indiquer par le  fabricant). IT: Conservare in luogo fresco lontano da .  .  . (materiali incompatibili da precisare da parte  del fabbricante). NL: Bewaren op een koele plaats verwijderd van .  .  . [stoffen waarmee contact vermeden dient te  worden, aan te geven door de fabrikant]. PT: Conservar em lugar fresco ao abrigo de .  .  . (matérias incompatíveis a indicar pelo  produtor). S 7/8 ES: Manténgase el recipiente bien cerrado y en lugar seco. DA: Emballagen skal holdes taet lukket og opbevares toert. DE: Behaelter trocken und dicht geschlossen halten. EL: Ôï aeï÷aassï íá aeéáôçñaassôáé aañìçôéêUE êëaaéóìÝíï êáé íá ðñïóôáôaaýaaôáé áðue ôçí õãñáóssá. EN: Keep container tightly closed and dry. FR: Conserver le récipient bien fermé et à l'abri de l'humidité. IT: Conservare il recipiente ben chiuso e al riparo dall'umidità. NL: Droog houden en in een goed gesloten verpakking bewaren. PT: Conservar o recipiente bem fechado e ao abrigo da humidade. S 7/9 ES: Manténgase el recipiente bien cerrado y en lugar bien ventilado. DA: Emballagen skal holdes taet lukket og opbevares paa et godt ventileret sted. DE: Behaelter dicht geschlossen an einem gut geluefteten Ort aufbewahren. EL: Ôï aeï÷aassï íá aeéáôçñaassôáé aañìçôéêUE êëaaéóìÝíï êáé óaa êáëUE áaañéaeueìaaíï ìÝñïò. EN: Keep container tightly closed and in a well-ventilated place. FR: Conserver le récipient bien fermé et dans un endroit bien ventilé. IT: Tenere il recipiente ben chiuso e in luogo ben ventilato. NL: Gesloten verpakking op een goed geventileerde plaats bewaren. PT: Manter o recipiente bem fechado em local bem ventilado. S 7/47 ES: Manténgase el recipiente bien cerrado y consérvese a una temperatura no superior a .  .  .  °C  (a especificar por el fabricante). DA: Emballagen skal holdes taet lukket og opbevares ved temperaturer paa ikke over .  .  .  °C  (angives af fabrikanten). DE: Behaelter dicht geschlossen und nicht bei Temperaturen ueber .  .  .  °C aufbewahren (vom  Hersteller anzugeben). EL: AEéáôçñaassóôaa ôï aeï÷aassï êáëUE êëaaéóìÝíï óaa èaañìïêñáóssá ðïõ aeaaí õðaañâássíaaé ôïõò .  .  .°C (íá  êáèïñéóôaass áðue ôïí ðáñáãùãue). EN: Keep container tightly closed and at a temperature not exceeding .  .  .  °C (to be specified  by the manufacturer). FR: Conserver le récipient bien fermé et à une température ne dépassant pas .  .  .  °C (à préciser  par le fabricant). IT: Tenere il recipiente ben chiuso e a temperatura non superiore a .  .  .  °C (da precisare da  parte del fabbricante). NL: Gesloten verpakking bewaren bij een temperatuur beneden .  .  .  °C. [aan te geven door de  fabrikant]. PT: Manter o recipiente bem fechado e conservar a uma temperatura que não exceda .  .  .  °C (a  especificar pelo produtor). S 20/21 ES: No comer, ni beber, ni fumar durante su utilización. DA: Der maa ikke spises, drikkes eller ryges under brugen. DE: Bei der Arbeit nicht essen, trinken, rauchen. EL: ¼ôáí ôï ÷ñçóéìïðïéaassôaa ìç ôñþôaa, ìçí ðssíaaôaa, ìç êáðíssaeaaôaa. EN: When using do not eat, drink or smoke. FR: Ne pas manger, ne pas boire et ne pas fumer pendant l'utilisation. IT: Non mangiare, né bere, né fumare durante l'impiego. NL: Niet eten, drinken of roken tijdens gebruik. PT: Não comer, beber ou fumar durante a utilização. S 24/25 ES: Evítese el contacto con los ojos y la piel.DA: Undgaa kontakt med huden og oejnene. DE: Beruehrung mit den Augen und der Haut vermeiden. EL: Áðïoeaaýãaaôaa aaðáoeÞ ìaa ôï aeÝñìá êáé ìaa ôá ìUEôéá. EN: Avoid contact with skin and eyes. FR: Éviter le contact avec la peau et les yeux. IT: Evitare il contatto con gli occhi e con la pelle. NL: Aanraking met de ogen en de huid vermijden. PT: Evitar o contacto com a pele e os olhos. S 29/56 ES: No tirar los residuos por el desaguee. DA: Maa ikke kommes i kloakafloeb, aflever dette materiale og dets beholder til et indsamlingssted  for farligt affald og problemaffald. DE: Nicht in die Kanalisation gelangen lassen. EL: ÌÞí áaeaaéUEaeaaôaa ôï ðaañéaa÷ueìaaíï óôçí áðï÷Ýôaaõóç. Ôï õëéêue áõôue êáé ï ðaañéÝêôçò ôïõ íá aaíáðïôaaèïýí  óaa aeçìueóéï ÷þñï óõëëïãÞò aaðéêéíaeýíùí Þ aaéaeéêþí áðïâëÞôùí. EN: Do not empty into drains, dispose of this material and its container at hazardous or special  waste collection point. FR: Ne pas jeter les résidus à l'égout, éliminer ce produit et son récipient dans un centre de  collecte des déchets dangereux ou spéciaux. IT: Non gettare i residui nelle fognature. NL: Afval niet in de gootsteen werpen. PT: Não deitar os resíduos no esgoto, eliminar este produto e o seu recipiente, enviando-os para  local autorizado para a recolha de resíduos perigosos ou especiais. S 36/37 ES: Úsense indumentaria y guantes de protección adecuados. DA: Brug saerligt arbejdstoej og egnede beskyttelseshandsker. DE: Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen. EL: OEïñUEôaa êáôUEëëçëç ðñïóôáôaaõôéêÞ aaíaeõìáóssá êáé ãUEíôéá. EN: Wear suitable protective clothing and gloves. FR: Porter un vêtement de protection et des gants appropriés. IT: Usare indumenti protettivi e guanti adatti. NL: Draag geschikte handschoenen en beschermende kleding. PT: Usar vestuário de protecção e luvas adequadas. S 36/37/39 ES: Úsense indumentaria y guantes adecuados y protección para los ojos/la cara. DA: Brug saerligt arbejdstoej, egnede beskyttelseshandsker og -briller/ansigtsskaerm. DE: Bei der Arbeit geeignete Schutzkleidung, Schutzhandschuhe und Schutzbrille/Gesichtsschutz  tragen. EL: OEïñUEôaa êáôUEëëçëç ðñïóôáôaaõôéêÞ aaíaeõìáóssá, ãUEíôéá êáé óõóêaaõÞ ðñïóôáóssáò ìáôéþí/ðñïóþðïõ. EN: Wear suitable protective clothing, gloves and eye/face protection. FR: Porter un vêtement de protection approprié, des gants et un appareil de protection des yeux/du  visage. IT: Usare indumenti protettivi e guanti adatti e proteggersi gli occhi/la faccia. NL: Draag geschikte beschermende kleding, handschoenen en een beschermingsmiddel voor de ogen/het  gezicht. PT: Usar vestuário de protecção, luvas e equipamento protector para a vista/face adequados. S 36/39 ES: Úsense indumentaria adecuada y protección para los ojos/la cara. DA: Brug saerligt arbejdstoej og egnede beskyttelsesbriller/ansigtsskaerm. DE: Bei der Arbeit geeignete Schutzkleidung und Schutzbrille/Gesichtsschutz tragen. EL: OEïñUEôaa êáôUEëëçëç ðñïóôáôaaõôéêÞ aaíaeõìáóssá êáé óõóêaaõÞ ðñïóôáóssáò ìáôéþí/ðñïóþðïõ. EN: Wear suitable protective clothing and eye/face protection. FR: Porter un vêtement de protection approprié et un appareil de protection des yeux/du visage. IT: Usare indumenti protettivi adatti e proteggersi gli occhi/la faccia. NL: Draag geschikte beschermende kleding en een beschermingsmiddel voor de ogen/het gezicht. PT: Usar vestuário de protecção e equipamento protector para a vista/face adequados. S 37/39 ES: Úsense guantes adecuados y protección para los ojos/la cara. DA: Brug egnede beskyttelseshandsker og -briller/ansigtsskaerm under arbejdet. DE: Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen. EL: OEïñUEôaa êáôUEëëçëá ãUEíôéá êáé óõóêaaõÞ ðñïóôáóssáò ìáôéþí/ðñïóþðïõ. EN: Wear suitable gloves and eye/face protection. FR: Porter des gants appropriés et un appareil de protection des yeux/du visage. IT: Usare guanti adatti e proteggersi gli occhi/la faccia. NL: Draag geschikte handschoenen en een beschermingsmiddel voor de ogen/het gezicht. PT: Usar luvas e equipamento protector para a vista/face adequados. S 47/49 ES: Consérvese únicamente en el recipiente de origen y a temperatura no superior a .  .  . °C (a  especificar por el fabricante). DA: Maa kun opbevares i originalemballagen ved en temperatur paa ikke over .  .  . °C (angives af  fabrikanten). DE: Nur im Originalbehaelter bei einer Temperatur von nicht ueber .  .  . °C (vom Hersteller  anzugeben) aufbewahren. EL: AEéáôçñaassôáé ìueíï ìÝóá óôï áñ÷éêue aeï÷aassï óaa èaañìïêñáóssá ðïõ aeÝí õðaañâássíaaé ôïõò .  .  .  °C  (êáèïñssaeaaôáé áðue ôïí ðáñáãùãue). EN: Keep only in the original container at a temperature not exceeding .  .  . °C (to be specified  by the manufacturer). FR: Conserver uniquement dans le récipient d'origine à une température ne dépassant pas .  .  . °C  (à préciser par le fabricant). IT: Conservare soltanto nel contenitore originale a temperatura non superiore a .  .  . °C (da  precisare da parte del fabbricante). NL: Uitsluitend in de oorspronkelijke verpakking bewaren bij een temperatuur beneden .  .  . °C.  [aan te geven door de fabrikant]. PT: Conservar unicamente no recipiente de origem a temperatura que não exceda .  .  . °C (a  especificar pelo produtor).   ANNEX IV ANNEX VI GENERAL CLASSIFICATION AND LABELLING REQUIREMENTS FOR DANGEROUS  SUBSTANCES AND PREPARATIONS CONTENTS 1. GENERAL INTRODUCTION 2. CLASSIFICATION ON THE BASIS OF PHYSICO-CHEMICAL PROPERTIES 2.1. Introduction 2.2. Criteria for classification, choice of symbols, indication of danger, choice of risk phrases 2.2.1. Explosive 2.2.2. Oxidizing 2.2.3. Extremely flammable 2.2.4. Highly flammable 2.2.5. Flammable 2.2.6. Other physico-chemical properties 3. CLASSIFICATION ON THE BASIS OF TOXICOLOGICAL PROPERTIES 3.1. Introduction 3.2. Criteria for classification, choice of symbols, indication of danger, choice of risk phrases 3.2.1. Very toxic 3.2.2. Toxic 3.2.3. Harmful 3.2.4. Comments regarding the use of R48 3.2.5. Corrosive 3.2.6. Irritant 3.2.7. Sensitizing 3.2.8. Other toxicological properties 4. CLASSIFICATION ON THE BASIS OF SPECIFIC EFFECTS ON HUMAN HEALTH 4.1. Introduction 4.2. Criteria for classification, indication of danger, choice of risk phrases 4.2.1. Carcinogenic substances 4.2.2. Mutagenic substances 4.2.3. Substances toxic to reproduction 4.2.4. Procedure for the classification of preparations 5. CLASSIFICATION ON THE BASIS OF ENVIRONMENTAL EFFECTS 5.1. Introduction 5.2. Criteria for classification, indication of danger, choice of risk phrases 5.2.1. Aquatic environment 5.2.2. Non-aquatic environment 6. CHOICE OF SAFETY ADVICE PHRASES 6.1. Introduction 6.2. Safety phrases for substances and preparations 7. LABELLING PROPOSAL 8. SPECIAL CASES : Substances 8.1. Mobile gas cylinders 8.2. Metals in massive form 9. SPECIAL CASES : Preparations 9.1. Gaseous preparations (gas mixtures) 9.2. Alloys, preparations containing polymers, preparations containing elastomers 9.3. Organic peroxides  1. GENERAL INTRODUCTION 1.1. The object of classification is to identify all the toxicological, physico-chemical and  ecotoxicological properties of substances and toxicological and physico-chemical properties of  preparations which may constitute a risk during normal handling or use. Having identified any  hazardous properties the substance or preparation must then be labelled to indicate the hazard(s)  in order to protect the user, the general public and the environment. 1.2. This Annex sets out the general principles governing the classification and labelling of  substances and preparations referred to in Article 4 of Directive 67/548/EEC and in Article 3 of  Directive 88/379/EEC and other relevant Directives on dangerous preparations.  It is addressed to all those concerned (manufacturers, importers, national authorities) with  methods of classifying and labelling dangerous substances and preparations. 1.3. The requirements of this Directive and of Directive 88/379/EEC are intended to provide a  primary means by which the general public and persons at work are given essential information about  dangerous substances and preparations. The label draws the attention of persons handling or using  substances and preparations to the inherent danger of certain such materials.  The label may also serve to draw attention to more comprehensive product information on safety and  use available in other forms. 1.4. The label takes account of all potential hazards which are likely to be faced in the normal  handling and use of dangerous substances and preparations when in the form in which they are placed  on the market, but not necessarily in any different form in which they may finally be used, e.g.  diluted. The most severe hazards are highlighted by symbols, such hazards and those arising from  other dangerous properties are specified in standard risk phrases, and safety phrases give advice  on necessary precautions.  In the case of substances, the information is completed by the name of the substance under an  internationally recognized chemical nomenclature, the preferred name being the one used in the  European Inventory of Existing Commercial Chemical Substances (Einecs), the European List of  Notified Chemical Substances (Elincs), the EEC number and the name, address and telephone number of  the person established in the Community who is responsible for placing the substance on the  market.  In the case of preparations, the information is completed by the indication of the designation or  the trade name of the preparation, the indication of the chemical name of the substances present in  the preparation in accordance with Article 7  (1)  (c) of Directive 88/379/EEC and the indication  of the name, address and telephone number of the person established in the Community who is  responsible for placing the preparation on the market. 1.5. Article 6 of Directive 67/548/EEC requires that manufacturers, distributors and importers of  dangerous substances which appear in the EINECS but which have not yet been introduced into Annex I  shall be obliged to carry out an investigation to make themselves aware of the relevant and  accessible data which exist concerning the properties of such substances. On the basis of this  information, they shall package and provisionally label these substances according to the rules  laid down in Articles 22 to 25 and the criteria in Annex VI. 1.6. For substances, the data required for classification and labelling may be obtained:  (a)  as regards substances for which the information specified in Annex VII is required, most of  the necessary data for classification and labelling appear in the 'base set`. This classification  and labelling must be reviewed, if necessary, when further information is available (Annex VIII);  (b)  as regards other substances (e.g. those referred to in section 1.5 above), the data required  for classification and labelling may, if necessary, be obtained from a number of different sources,  for example the results of previous tests, information required by international rules on the  transport of dangerous substances, information taken from reference works and the literature or  information derived from practical experience.  For preparations, the data required for classification and labelling may be obtained:  (a)  if it concerns physico-chemical data, by the application of the methods specified in Annex V  to Directive 67/548/EEC. For gaseous preparations a calculation method may be used for flammable  and oxidising properties (see Chapter 9);  (b)  if it concerns data on health effects:  -  by the application of the methods specified in Annex V to the Directive and/or by the  application of the conventional method referred to in Article 3 (5) (a) to (i) of Directive  88/379/EEC,  -  however, if it concerns the evaluation of the carcinogenic, mutagenic and reproductive toxicity  properties, by the application of the conventional method referred to in Article 3 (5) (j) to (q)  of Directive 88/379/EEC.  Note concerning the performance of animal tests  The performance of animal tests to establish experimental data is subject to the provisions of  Directive 86/609/EEC regarding the protection of animals used for experimental purposes. 1.7. Application of the guide criteria  Classification must cover the toxicological and physico-chemical properties of substances and  preparations, and in addition the ecotoxicological properties of substances.  Classification of substances and preparations is made on the basis of the criteria in Chapters 2  to 4 and additionally for substances Chapter 5 of this Annex. All types of hazard must be  considered. For instance, classification under 3.2.1 does not imply that the sections such as 3.2.2  or 3.2.4 can be ignored.  The choice of symbol(s) and risk phrase(s) is made on the basis of the classification in order to  ensure that the specific nature of the potential dangers identified in classification is expressed  on the label.  Notwithstanding the criteria given under 2.2.3, 2.2.4 and 2.2.5, substances and preparations in  the form of aerosols shall be subject to the flammability criteria set out in 1.8 and 2.2  (c) of  the Annex to Directive 75/324/EEC. 1.7.1. Definitions  'Substances` means chemical elements and their compounds in the natural state or obtained by any  production process, including any additive necessary to preserve the stability of the product, and  any impurity deriving from the production process used, but excluding any solvent which may be  separated without affecting the stability of the substance or changing its composition.  A substance may be chemically very well defined (e.g. acetone) or a complex mixture of  constituents of variable composition (e.g. aromatic distillates). For certain complex substances,  some individual constituents have been identified.  'Preparations` means mixtures or solutions composed of two or more substances. 1.7.2. Application of the guide criteria for substances  The guidance criteria set out in this Annex are directly applicable when the data in question have  been obtained from test methods comparable with those described in Annex V. In other cases, the  available data must be evaluated by comparing the test methods employed with those indicated in  Annex V and the rules specified in this Annex for determining the appropriate classification and  labelling. 1.7.2.1. Classification of substances containing impurities, additives or individual constituents  Where impurities, additives or individual constituents of substances have been identified, they  shall be taken into account if their concentration is greater than or equal to the limits  specified:  -  0,1  % for substances classified as very toxic, toxic, carcinogenic (category 1 or 2),  mutagenic (category 1 or 2) or toxic to reproduction (category 1 or 2),  -  1  % for substances classified as harmful, corrosive, irritant, sensitising, carcinogenic  (category 3), mutagenic (category 3) or toxic to reproduction (category 3).  unless lower values have been specified in Annex I to Directive 67/548/EEC.  With the exception of substances listed specifically in Annex I, classification for  physico-chemical properties and for health hazards should be carried out according to the  requirements of Article 3 and labelled according the requirements of Article 7 of Council Directive  88/379/EEC.  Classification for physico-chemical properties is carried out according to the criteria in Chapter  2, and for effects dangerous for the environment is carried out according to the criteria in  Chapter 5 of this Annex.  In the case of asbestos (650-013-00-6) this general rule does not apply until a concentration  limit has been fixed in Annex I. Substances in which asbestos is present must be classified and  labelled according to the principles in Article 6 of Directive 67/548/EEC. 1.7.3. Application of the guide criteria for preparations  The guidance criteria set out in this Annex are directly applicable when the data in question have  been obtained from test methods comparable with those described in Annex V with the exception of  the criteria of Chapter 4 for which only the conventional method is applicable. In other cases, the  available data must be evaluated by comparing the test methods employed with those indicated in  Annex V and the rules specified in this Annex for determining the appropriate classification and  labelling.  If the health hazards are assessed by applying the conventional method referred to in Article 3   (5) of Directive 88/379/EEC, the individual concentration limits to be used are those set out,  either:  -  in Annex I to Directive 67/548/EEC, or  -  in Annex I to Directive 88/379/EEC where the substance or substances do not appear in Annex I  to Directive 67/548/EEC or appear in it without concentration limits.  In the case of preparations containing mixtures of gases, classification with respect to the  health effects will be established by the calculation method on the basis of the individual  concentration limits from Annex I to Directive 67/548/EEC or, when these limits are not in Annex I  on the basis of the criteria of Annex I to Directive 88/379/EEC, as amended by Directive  90/492/EEC. 1.7.3.1. Preparations or substances described in Section 1.7.2.1 used as constituents of another  preparation  The labelling of such preparations must be in conformity with the provisions of Article 7  according to the conditions foreseen in Article 3 of Directive 88/379/EEC. However, in certain  cases, the information on the label of the preparation or substance described in Section 1.7.2.1 is  insufficient to enable other manufacturers who wish to use it as a constituent of their own  preparation(s) to carry out the classification and labelling of their preparation(s) correctly.  In these cases, the person established within the Community responsible for placing the original  preparation or substance described in Section 1.7.2.1 on the market, whether it be the  manufacturer, the importer or the distributor, shall supply upon justified request and as soon as  possible all necessary data concerning the dangerous substances present to enable correct  classification and labelling of the new preparation. This data is also necessary to enable the  person responsible for the new preparation on the market to comply with other requirements of  Directive 88/379/EEC. 2. CLASSIFICATION ON THE BASIS OF PHYSICO-CHEMICAL PROPERTIES 2.1. Introduction  The test methods relating to explosive, oxidizing and flammable properties included in Annex V of  Directive 67/548/EEC serve to give specific meaning to the general definitions given in Article 2  (2) (a) to (e). Criteria follow directly from the test methods in Annex V as far as they are  mentioned.  If adequate information is available to demonstrate in practice that the physico-chemical  properties of substances and preparations (apart from organic peroxides) are different from those  revealed by the test methods given in Annex V, then such substances and preparations should be  classified according to the hazard they present, if any, to those handling the substances and  preparations or to other persons.  2.2. Criteria for classification, choice of symbols, indication of danger and choice of risk  phrases  In the case of preparations, the criteria referred to in Article 3 (2) of Directive 88/379/EEC  need to be taken into consideration. 2.2.1. Explosive  Substances and preparations shall be classified as explosive and assigned the symbol 'E` and the  indication of danger 'explosive` in accordance with the results of the tests given in Annex V and  in so far as the substances and preparations are explosive as placed on the market. One risk phrase  is obligatory, it is to be specified on the basis of the following:  R2  Risk of explosion by shock, friction, fire or other sources of ignition -  substances and preparations except those set out below.  R3  Extreme risk of explosion by shock, friction, fire or other sources of ignition -  substances and preparations which are particularly sensitive such as picric acid salts or PETN. 2.2.2. Oxidizing  Substances and preparations shall be classified as oxidizing and assigned the symbol 'O` and the  indication of danger 'oxidizing` in accordance with the results of the tests given in Annex V. One  risk phrase is obligatory, it is to be specified on the basis of the test results but subject to  the following:  R7  May cause fire -  organic peroxides which have flammable properties even when not in contact with other  combustible material.  R8  Contact with combustible material may cause fire -  other oxidizing substances and preparations, including inorganic peroxides, which may cause fire  or enhance the risk of fire when in contact with combustible material.  R9  Explosive when mixed with combustible material -  other substances and preparations, including inorganic peroxides, which become explosive when  mixed with combustible materials, e.g. certain chlorates. 2.2.2.1. Remarks concerning peroxides  For the oxidizing properties the existing methods in Annex V cannot be applied to organic  peroxides.  For substances, organic peroxides are classified as oxidizing on the basis of their structure  (e.g. R-O-O-H; R1-O-O-R2).  Preparations shall be classified using the calculation method based on the presence of active  oxygen shown in Section 9.3.  Any organic peroxide or preparation thereof is classified as oxidizing, if the peroxide or its  formulation contains:  -  more than 5  % of organic peroxides or,  more than 0,5  % available oxygen from the organic peroxides, and not more than 5  % hydrogen  peroxide. 2.2.3. Extremely flammable  Substances and preparations shall be classified as extremely flammable and assigned the symbol  'F+` and the indication of danger 'extremely flammable` in accordance with the results of the tests  given in Annex V. The risk phrase shall be assigned in accordance with the following criteria:  R12  Extremely flammable -  Liquid substances and preparations which have a flash point lower than 0  °C and a boiling point  (or in case of a boiling range the initial boiling point) lower than or equal to 35  °C. -  Gaseous substances and preparations which are flammable in contact with air at ambient  temperature and pressure. 2.2.4. Highly flammable  Substances and preparations shall be classified as highly flammable and assigned the symbol 'F`  and the indication of danger 'highly flammable` in accordance with the results of the tests given  in Annex V. Risk phrases shall be assigned in accordance with the following criteria:  R11  Highly flammable -  Solid substances and preparations which may readily catch fire after brief contact with a source  of ignition and which continue to burn or to be consumed after removal of the source of ignition. -  Liquid substances and preparations having a flash point below 21°C but which are not extremely  flammable.  R15  Contact with water liberates extremely flammable gases -  Substances and preparations which, in contact with water or damp air, evolve extremely flammable  gases in dangerous quantities, at a minimum rate of one litre per kilogram per hour.  R17  Spontaneously flammable in air -  Substances and preparations which may become hot and finally catch fire in contact with air at  ambient temperature without any input of energy. 2.2.5. Flammable  Substances and preparations shall be classified as flammable in accordance with the results of the  tests given in Annex V. The risk phrase shall be assigned in accordance with the criteria mentioned  below.  R10  Flammable -  Liquid substances and preparations having a flash point equal to or greater than 21  °C, and  less than or equal to 55  °C.  However, in practice it has been shown that a preparation having a flash point equal to or greater  than 21  °C and less than or equal to 55  °C need not be classified as flammable if the preparation  could not in any way support combustion and only so long as there is no reason to fear risks to  those handling these preparations or to other persons. 2.2.6. Other physico-chemical properties  Additional risk phrases shall be assigned to substances and preparations which have been  classified by virtue of Sections 2.2.1 to 2.2.5 above or by Chapter 3, 4 and 5 below, in accordance  with the following criteria (based on experience obtained during compilation of Annex I):  R1  Explosive when dry For explosive substances and preparations put on the market in solution or in a wetted form; e.g.  nitrocellulose with more than 12,6  % nitrogen.  R4  Forms very sensitive explosive metallic compounds For substances and preparations which may form sensitive explosive metallic derivatives, e.g.  picric acid, styphnic acid.  R5  Heating may cause an explosion For thermally unstable substances and preparations not classified as explosive, e.g. perchloric  acid > 50  %.  R6  Explosive with or without contact with air For substances and preparations which are unstable at ambient temperatures, e.g. acetylene.  R7  May cause fire For reactive substances and preparations : e.g. fluorine, sodium hydrosulphite.  R14  Reacts violently with water For substances and preparations which react violently with water, e.g. acetyl chloride, alkali  metals, titanium tetrachloride.  R16  Explosive when mixed with oxidizing substances For substances and preparations which react explosively with an oxidizing agent, e.g. red  phosphorus.  R18  In use, may form flammable/explosive vapour-air mixture For preparations not in themselves classified as flammable, which contain volatile components which  are flammable in air.  R19  May form explosive peroxides For substances and preparations which may form explosive peroxides during storage, e.g. diethyl  ether, 1,4-dioxan.  R30  Can become highly flammable in use For preparations not in themselves classified as flammable, which may become flammable due to the  loss of non-flammable volatile components.  R44  Risk of explosion if heated under confinement For substances and preparations not in themselves classified as explosive in accordance with  Section 2.2.1 above but which may nevertheless display explosive properties in practice if heated  under sufficient confinement. For example, certain substances which would decompose explosively if  heated in a steel drum do not show this effect if heated in less-strong containers.  For other additional risk phrases see Section 3.2.7. 3. CLASSIFICATION ON THE BASIS OF TOXICOLOGICAL PROPERTIES 3.1. Introduction 3.1.1. Classification is concerned with both the acute and long-term effects of substances and  preparations, whether resulting from a single instance of exposure or repeated or prolonged  exposure.  If adequate evidence is available to demonstrate in practice that the toxic effect of substances  and preparations on man is, or is likely to be, different from that suggested by the experimental  results obtained in animal tests or by the application of the conventional method referred to in  Article 3 (5) of Directive 88/379/EEC then such substances and preparations should be classified  according to their toxicity in man. However, tests on man should be discouraged and should not  normally be used to negate positive animal data. 3.1.2. The classification of substances must be made on the basis of the experimental data  available in accordance with the following criteria which take into account the magnitude of these  effects:  (a)  for acute toxicity (lethal and irreversible effects after a single exposure), the criteria  under Sections 3.2.1 to 3.2.3 are to be used,  (b)  for subacute, subchronic or chronic toxicity the criteria under Sections 3.2.2 to 3.2.4 are  to be used,  (c)  for corrosive and irritant effects the criteria under Sections 3.2.5 and 3.2.6 are to be  used,  (d)  for sensitising effects the criteria under Section 3.2.7 are to be used,  (e)  for specific effects on health (carcinogenicity, mutagenicity and reproductive toxicity, the  criteria in Chapter 4 are to be used. 3.1.3. For preparations, the classification relating to dangerous for health is carried out:  (a)  on the basis of the conventional method referred to in Article 3 (5) of Directive 88/379/EEC  in the absence of experimental data. In this case, the classification is based on the individual  concentration limits:  -  either taken from Annex I to Directive 67/548/EEC,  -  or from Annex I to Directive 88/379/EEC where the substance or substances do not appear in  Annex I of Directive 67/548/EEC or appear in it without concentration limits.  b)  or when experimental data are available, according to the criteria described under Sections  3.1.2 excluding the carcinogenic, mutagenic and toxic to reproduction properties referred to under  3.1.2 (e) which must be evaluated by the conventional method referred to in Article 3 (5) (j) to  (q) of Directive 88/379/EEC. Whichever method is used for the evaluation of the danger of a  preparation, all the dangerous effects on health as defined in Annex I to Directive 88/379/EEC must  be taken into consideration. 3.1.4. When the classification is to be established from experimental  results obtained in animal tests the results should have validity for man in that the tests  reflect, in an appropriate way, the risks to man. 3.1.5. The acute oral toxicity of substances or preparations placed on the market may be  established either by a method permitting assessment of the LD50 value, or by determining the  discriminating dose (the fixed dose procedure).  The discriminating dose is the dose which causes evident toxicity but not mortality and must be  one of the four dosage levels specified in Annex V (5, 50, 500 or 2  000 mg per kg per body  weight).  The concept 'evident toxicity` is used to designate toxic effects, after exposure to the substance  tested, which are so severe that exposure to the next highest fixed dose would probably lead to  mortality.  The results of testing at a particular dose may be either:  -  less than 100  % survival,  -  100  % survival, but evident toxicity,  -  100  % survival, but no evident toxicity.  The test method requires in some cases testing at higher or lower doses, if not already tested at  the relevant dose level. Refer also to the evaluation table in test method B1 (a) of Annex V.  In the criteria in sections 3.2.1, 3.2.2 and 3.2.3 only the final test result is shown. The 2  000  mg/kg dose should be used primarily to obtain information on the toxic effects of substances which  are of low acute toxicity and which are not classified on the basis of acute toxicity. 3.2. Criteria for classification, choice of symbols, indication of danger, choice of risk phrases 3.2.1. Very toxic  Substances and preparations shall be classified as very toxic, and assigned the symbol 'T +` and  indication of danger 'very toxic` in accordance with the criteria specified below.  Risk phrases shall be assigned in accordance with the following criteria:  R28  Very toxic if swallowed Acute toxicity results:-  LD50 oral, rat &le; 25 mg/kg, -  less than 100  % survival at 5 mg/kg oral, rat by the fixed dose procedure.  R27  Very toxic in contact with skin Acute toxicity results: -  LD50 dermal, rat or rabbit: &le; 50 mg/kg.  R26  Very toxic by inhalation Acute toxicity results: -  LC50 inhalation, rat, for aerosols or particulates: &le; 0,25 mg/litre/4hr, -  LC50 inhalation, rat, for gases and vapours: &le; 0,5 mg/litre/4hr.  R39  Danger of very serious irreversible effects -  Strong evidence that irreversible damage other than the effects referred to in Chapter 4 is  likely to be caused by a single exposure by an appropriate route, generally in the above mentioned  dose range. In order to indicate the route of administration/exposure one of the following combinations shall  be used: R39/26, R39/27, R39/28, R39/26/27, R39/26/28, R39/27/28, R39/26/27/28. 3.2.2. Toxic  Substances and preparations shall be classified as toxic and assigned the symbol 'T` and the  indication of danger 'toxic` in accordance with the criteria specified below. Risk phrases shall be  assigned in accordance with the following criteria.  R25  Toxic if swallowed Acute toxicity results: -  LD50 oral, rat: 25 < LD50 &le; 200 mg/kg, -  Discriminating dose, oral, rat, 5 mg/kg: 100  % survival but evident toxicity.  R24  Toxic in contact with skin Acute toxicity results: -  LD50 dermal, rat or rabbit: 50 < LD50 &le; 400 mg/kg.  R23  Toxic by inhalation Acute toxicity results: -  LC50 inhalation, rat, for aerosols or particulates: 0,25 < LC50 &le; 1 mg/litre/4hr, -  LC50 inhalation, rat, for gases and vapours: 0,5 < LC50 &le; 2 mg/litre/4hr.  R39  Danger of very serious irreversible effects -  strong evidence that irreversible damage other than the effects referred to in Chapter 4 is  likely to be caused by a single exposure by an appropriate route, generally in the abovementioned  dose range. In order to indicate the route of administration/exposure one of the following combinations shall  be used: R39/23, R39/24, R39/25, R39/23/24, R39/23/25, R39/24/25, R39/23/24/25.  R48  Danger of serious damage to health by prolonged exposure -  serious damage (clear functional disturbance or morphological change which have toxicological  significance) is likely to be caused by repeated or prolonged exposure by an appropriate route. Substances and preparations are classified at least as Toxic when these effects are observed at  levels of one order of magnitude lower (i.e. 10-fold) than those set out for R48 in Section 3.2.3. In order to indicate the route of administration/exposure one of the following combinations shall  be used: R48/23, R48/24, R48/25, R48/23/24, R48/23/25, R48/24/25, R48/23/24/25. 3.2.3. Harmful  Substances and preparations shall be classified as harmful and assigned the symbol 'Xn` and the  indication of danger 'harmful` in accordance with the criteria specified below. Risk phrases shall  be assigned in accordance with the following criteria:  R22  Harmful if swallowed Acute toxicity results: -  LD50 per oral, rat: 200 &le; LD50 < 2000 mg/kg, -  discriminating dose, oral, rat, 50 mg/kg: 100  % survival but evident toxicity, -  less than 100  % survival at 500 mg/kg, rat oral by the fixed dose procedure. Refer to the  evaluation table in the test method B1 (a) of Annex V.  R21  Harmful in contact with skin Acute toxicity results: -  LD50 dermal, rat or rabbit: 400 < LD50 &le; 2  000 mg/kg  R20  Harmful by inhalation Acute toxicity results: -  LC50 inhalation, rat, for aerosols or particulates: 1 < LC50 &le; 5 mg/litre/4hr, -  LC50 inhalation, rat, for gases or vapours: 2 < LC50 &le; 20 mg/litre/4hr.  R40  Possible risk of irreversible effects -  strong evidence that irreversible damage other than the effects referred to in Chapter 4 is  likely to be caused by a single exposure by an appropriate route, generally in the abovementioned  dose range. In order to indicate route of administration/exposure one of the following combinations shall be  used: R40/20, R40/21, R40/22, R40/20/21, R40/20/22, R40/21/22, R40/20/21/22.  R48  Danger of serious damage to health by prolonged exposure -  serious damage (clear functional disturbance or morphological change which has toxicological  significance) is likely to be caused by repeated or prolonged exposure by an appropriate route. Substances and preparations are classified at least as harmful when these effects are observed at  levels of the order of: -  oral, rat &le; 50 mg/kg (bodyweight)/day, -  dermal, rat or rabbit &le; 100 mg/kg (bodyweight)/day, -  inhalation, rat &le; 0,25 mg/l, 6h/day. These guide values can apply directly when severe lesions have been observed in a subchronic (90  days) toxicity test. When interpreting the results of a sub-acute (28 days) toxicity test these  figures should be increased approximately three fold. If a chronic (two years) toxicity test is  available it should be evaluated on a case-by-case basis. If results of studies of more than one  duration are available, then those from the study of the longest duration should normally be used. In order to indicate route of administration/exposure one of the following combinations shall be  used: R48/20, R48/21, R48/22, R48/20/21, R48/20/22, R48/21/22, R48/20/21/22. 3.2.3.1. Comments regarding very volatile substances  For certain substances with a high saturated vapour concentration evidence may be available to  indicate effects that give cause for concern. Such substances may not be classified under the  criteria for health effects in this guide (3.2.3). However, where there is appropriate evidence  that such substances may present a risk in normal handling and use then classification as 'harmful`  on a case-by-case basis with an appropriate phrase may be necessary.  Such substances will be classified in Annex I with appropriate concentration limits. 3.2.4. Comments regarding the use of R48  Use of this risk phrase refers to the specific range of biological effects within the terms  described below. For application of this risk phrase serious damage to health is to be considered  to include death, clear functional disturbance or morphological changes which are toxicologically  significant. It is particularly important when these changes are irreversible. It is also important  to consider not only specific severe changes in a single organ or biological system but also  generalized changes of a less severe nature involving several organs, or severe changes in general  health status.  When assessing whether there is evidence for these types of effects reference should be made to the  following guidelines: 1.  Evidence indicating that R48 should be applied: (a)  substance-related  deaths; (b)  (i)  major functional changes in the central or peripheral nervous systems, including  sight, hearing and the sense of smell, assessed by clinical observations or other appropriate  methods (e.g. electrophysiology); (ii)  major functional changes in other organ systems (for  example the lung); (c)  any consistent changes in clinical biochemistry, haematology or urinalysis  parameters which indicate severe organ dysfunction. Haematological disturbances are considered to  be particularly important if the evidence suggests that they are due to decreased bone marrow  production of blood cells; (d)  severe organ damage noted on microscopic examination following  autopsy; (i)  widespread or severe necrosis, fibrosis or granuloma formation in vital organs with  regenerative capacity (e.g. liver); (ii)  severe morphological changes that are potentially  reversible but are clear evidence of marked organ dysfunction (e.g. severe fatty change in the  liver, severe acute tubular nephrosis in the kidney, ulcerative gastritis); (iii)  evidence of  appreciable cell death in vital organs incapable of regeneration (e.g. fibrosis of the myocardium  or dying back of a nerve) or in stem cell populations (e.g. aplasia or hypoplasia of the bone  marrow). The above evidence will most usually be obtained from animal experiments. When considering  data derived from practical experience special attention should be given to exposure levels. 2.   Evidence indicating that R48 should not be applied. The use of this risk phrase is restricted to  'serious damage to health by prolonged exposure`. A number of substance-related effects may be  observed in both humans and animals that would not justify the use of R48. These effects are  relevant when attempting to determine a no-effect level for a chemical substance. Examples of well  documented changes which would not normally justify classification with R48, irrespective of their  statistical significance, include: (a)  clinical observations or changes in bodyweight gain, food  consumption or water intake, which may have some toxicological importance but which do not, by  themselves, indicate 'serious damage`; (b)  small changes in clinical biochemistry, haematology or  urinalysis parameters which are of doubtful or minimal toxicological importance; (c)  changes in  organ weights with no evidence of organ dysfunction; (d)  adaptative responses (e.g. macrophage  migration in the lung, liver hypertrophy and enzyme induction, hyperplastic responses to  irritants). Local effects on the skin produced by repeated dermal application of a substance which  are more appropriately classified with R38 'irritating to skin`; (e)  where a species-specific  mechanism of toxicity (e.g. specific metabolic pathways) has been demonstrated. 3.2.5. Corrosive  A substance or a preparation is considered to be corrosive if, when it is applied to healthy  intact animal skin, it produces full thickness destruction of skin tissue on at least one animal  during the test for skin irritation cited in Annex V or during an equivalent method or if the  results can be predicted, for example from strongly acid or alkaline reactions (demonstrated pH of  2 or less or 11,5 or greater. Alkaline or acidic reserve should also be taken into account).  Classification can be based on the results of validated in vitro tests.  The substance or preparation shall be classified as corrosive and assigned the symbol 'C` and the  indication of danger 'corrosive`. Risk phrases shall be assigned in accordance with the following  criteria:  R35  Causes severe burns -  if, when applied to healthy intact animal skin, full thickness destruction of skin tissue occurs  as a result of up to three minutes exposure, or if this result can be predicted.  R34  Causes burns -  if, when applied to healthy intact animal skin, full thickness destruction of skin tissue occurs  as a result of up to four hours exposure, or if this result can be predicted, -  organic hydroperoxides, except where evidence to the contrary is available. 3.2.6. Irritant  Substances and preparations shall be classified as irritant and assigned the symbol 'Xi` and the  indication of danger 'irritant` in accordance with the criteria given below. 3.2.6.1. Inflammation of the skin  The following risk phrase shall be assigned in accordance with the criteria given:  R38  Irritating to skin -  Substances and preparations which cause significant inflammation of the skin which persists for  at least 24 hours after an exposure period of up to four hours determined on the rabbit according  to the cutaneous irritation test method cited in Annex V. Inflammation of the skin is significant if: -  the mean value of the scores for either erythema and eschar formation or oedema formation,  calculated over all the animals tested, is 2 or more, -  or, in the case where the Annex V test has been completed using three animals, either erythema  and eschar formation or oedema formation equivalent to a mean value of 2 or more calculated for  each animal separately has been observed in two or more animals. In both cases all scores at each of the reading times (24, 48 and 72 hours) for an effect should be  used in calculating the respective mean values. Inflammation of the skin is also significant if it persists in at least two animals at the end of  the observation time. Particular effects e.g. hyperplasia, scaling, discolouration, fissures, scabs  and alopecia should be taken into account. -  Substances and preparations which cause significant inflammation of the skin, based on practical  observation in humans. -  Organic peroxides, except where evidence to the contrary is available.  Irritation due to the defatting properties of a substance:  When test results or practical experience show irritation in accordance with the above criteria,  R-phrases should be used. However, S-phrases should be used when there are reasons to suspect that  the defatting properties of the substance may cause irritation in man even though the above  criteria are not met, or if an inappropriate test has been used. 3.2.6.2. Ocular lesions  The following risk phrases shall also be assigned in accordance with the criteria given:  R36  Irritating to eyes -  Substances and preparations which, when applied to the eye of the animal, cause significant  ocular lesions which occur within 72 hours after exposure and which persist for at least 24 hours. Ocular lesions are significant if the mean scores of the eye irritation test cited in Annex V have  any of the following values: -  cornea opacity equal to or greater than 2 but less than 3, -  iris lesion equal to or greater than 1 but not greater than 1,5, -  redness of the conjunctivae equal to or greater than 2,5, -  oedema of the conjunctivae (chemosis) equal to or greater than 2, or, in the case where the Annex V test has been completed using three animals if the lesions, on  two or more animals, are equivalent to any of the above values except that for iris lesion the  value should be equal to or greater than 1 but less than 2 and for redness of the conjunctivae the  value should be equal to or greater than 2,5. In both cases all scores at each of the reading times (24, 48 and 72 hours) for an effect should be  used in calculating the respective mean values. -  Substances or preparations which cause significant ocular lesions, based on practical experience  in humans. -  Organic peroxides except where evidence to the contrary is available.  R41  Risk of serious damage to eyes -  Substances and preparations which, when applied to the eye of the animal cause severe ocular  lesions which occur within 72 hours after exposure and which persist for at least 24 hours. Ocular lesions are severe if the means of the scores of the eye irritation test in Annex V have any  of the values: -  cornea opacity equal to or greater than 3, -  iris lesion greater than 1,5. The same shall be the case where the test has been completed using three animals if these lesions,  on two or more animals, have any of the values: -  cornea opacity equal to or greater than 3, - iris lesion equal to 2. In both cases all scores at each of the reading times (24, 48 and 72 hours) for an effect should be  used in calculating the respective mean values. Ocular lesions are also severe when they are still present at the end of the observation time. Ocular lesions are also severe if the substance or preparation causes irreversible colouration of  the eyes. -  Substances and preparations which cause severe ocular lesions, based on practical experience in  humans.  Note:  When a substance or preparation is classified as corrosive and assigned R34 or R35, the risk of  severe damage to eyes is considered implicit and R41 is not included in the label. However, in the  case of preparations, when calculating the sum of quotients by the formulae in 3,5 (f)  (ii) and  3,5 (h)  (ii) of Directive 88/379/EEC substances classified as corrosive shall be considered as if  R41 had been assigned. 3.2.6.3. Respiratory system irritation  The following risk phrase shall be assigned in accordance with the criteria given:  R37  Irritating to respiratory system -  Substances and preparations which cause serious irritation to the respiratory system, based  normally on practical observation in humans. 3.2.7 Sensitizing 3.2.7.1 Sensitization by inhalation  Substances and preparations shall be classified as sensitizing and assigned the symbol Xn, the  indication of danger 'Harmful` and the risk phrase R42 in accordance with the criteria given  below.  R42  May cause sensitization by inhalation -  If practical evidence is available which shows the substances and preparations to be capable of  inducing a sensitization reaction in humans by inhalation, at a greater frequency than would be  expected from the response of a general population. -  If the substance is an isocyanate, unless there is evidence that the substance does not cause  sensitization by inhalation. 3.2.7.2. Sensitization by skin contact  Substances and preparations shall be classified as sensitizing and assigned the symbol 'Xi`, the  indication of danger 'Irritant` and the risk phrase R43 in accordance with the criteria given  below:  R43  May cause sensitization by skin contact -  If practical experience shows the substances and preparations to be capable of inducing a  sensitization reaction in a substantial number of persons by skin contact, or on the basis of a  positive response in experimental animals.  In the case of the adjuvant type test method for skin sensitization detailed in Annex V or in the  case of other adjuvant-type test methods, a response of at least 30% of the animals is considered  positive. For any other test method a response of at least 15% of the animals is considered  positive. 3.2.7.3. Note that if the symbol 'Xn` and the indication of danger 'Harmful` are assigned, the  symbol 'Xi` and indication of danger 'Irritant` are optional. 3.2.8. Other toxicological properties  Additional risk phrases shall be assigned to substances and preparations classified by virtue of  2.2.1. to 3.2.7. above and/or chapters 4 and 5 in accordance with the following criteria (based on  experience obtained during compilation of Annex I):  R29  Contact with water liberates toxic gas For substances and preparations which in contact with water or damp air, evolve very toxic/toxic  gases in potentially dangerous amounts, e.g. aluminium phosphide, phosphorus pentasulphide.  R31  Contact with acids liberates toxic gas For substances and preparations which react with acids to evolve toxic gases in dangerous amounts,  e.g. sodium hypochlorite, barium polysulphide. For substances used by members of the general  public, the use of S50 (do not mix with .  .  . (to be specified by the manufacturer)) would be  more suitable. R32  Contact with acids liberates very toxic gas For substances and preparations which react with acids to evolve very toxic gases in dangerous  amounts; e.g. salts of hydrogen cyanide, sodium azide. For substances used by members of the  general public, the use of S50 (do not mix with .  .  . (to be specified by the manufacturer))  would be more suitable. R33  Danger of cumulative effects For substances and preparations when accumulation in the human body is likely and may cause some  concern which, however, is not sufficient to justify the use of R48. R64  May cause harm to  breastfed babies For substances and preparations which are absorbed by women and may interfere with lactation or  which may be present (including metabolites) in breast milk in amounts sufficient to cause concern  for the health of a breastfed child. For comments on the use & this R-phrase (and in some cases R33) see Section 4.2.3.3. For other  supplementary risk phrases see Section 2.2.6. 4. CLASSIFICATION ON THE BASIS OF SPECIFIC EFFECTS ON  HUMAN HEALTH 4.1. Introduction 4.1.1. This Chapter sets out the procedure for the classification of substances which may have the  effects mentioned below. 4.1.2. If a manufacturer or his representative has information available which indicates that a  substance should be classified and labelled in accordance with the criteria given in Section  4.2.1., 4.2.2. or 4.2.3., he or his representative shall provisionally label the substance in  accordance with these criteria, unless the conclusions reached by the application of the criteria  mentioned in Sections 3.2.1. to 3.2.5. indicate the need for a more severe classification. 4.1.3. The manufacturer or his representative shall submit as soon as possible a document  summarizing all relevant information to one Member State in which the substance is placed on the  market. This summary document should include a bibliography containing all relevant references,  including any relevant unpublished data. 4.1.4. Furthermore, a manufacturer or his representative who has new data which are relevant to the  classification and labelling of a substance in accordance with the criteria given in Section  4.2.1., 4.2.2. or 4.2.3., shall submit this data as soon as possible to one Member State in which  the substance is placed on the market. 4.1.5. In order to obtain as quickly as possible a harmonized classification for the Community by  the procedure defined in Article 28 of Directive 67/548/EEC, Member States which have relevant  information available justifying the classification of a substance in one of these categories,  whether submitted by the manufacturer or not, should forward such information together with  suggestions for classification and labelling, to the Commission as soon as possible.  The Commission will forward to the other Member States the classification and labelling proposal  that it receives. Any Member State may ask the Commission for the information it has received.  Any Member State which has good reason to believe that the suggested classification and labelling  is inappropriate as far as the carcinogenic, mutagenic or reproductive toxicity effects are  concerned shall notify the Commission thereof. 4.2. Criteria for classification, indication of danger, choice of risk phrases 4.2.1. Carcinogenic substances  For the purpose of classification and labelling, and having regard to the current state of  knowledge, such substances are divided into three categories:  Category 1  Substances known to be carcinogenic to man. There is sufficient evidence to establish a causal  association between human exposure to a substance and the development of cancer.  Category 2  Substances which should be regarded as if they are carcinogenic to man. There is sufficient  evidence to provide a strong presumption that human exposure to a substance may result in the  development of cancer, generally on the basis of:  -  appropriate long-term animal studies,  -  other relevant information.  Category 3  Substances which cause concern for man owing to possible carcinogenic effects but in respect of  which the available information is not adequate for making a satisfactory assessment. There is some  evidence from appropriate animal studies, but this is insufficient to place the substance in  Category 2. 4.2.1.1. The following symbols and specific risk phrases apply:  Categories 1 and 2:  T; R45 May cause cancer  However for substances and preparations which present a carcinogenic risk only when inhaled, for  example, as dust, vapour or fumes, (other routes of exposure e.g. by swallowing or in contact with  skin do not present any carcinogenic risk), the following symbol and specific risk phrase should be  used:  T; R49 May cause cancer by inhalation  Category 3:  Xn; R40 Possible risk of irreversible effects 4.2.1.2. Comments regarding the categorisation of carcinogenic substances  The placing of a substance into Category 1 is done on the basis of epidemiological data; placing  into Categories 2 and 3 is based primarily on animal experiments.  For classification as a Category 2 carcinogen either positive results in two animal species should  be available or clear positive evidence in one species, together with supporting evidence such as  genotoxicity data, metabolic or biochemical studies, induction of benign tumours, structural  relationship with other known carcinogens, or data from epidemiological studies suggesting an  association.  Category 3 actually comprises 2 sub-categories:  (a)  substances which are well investigated but for which the evidence of a tumour-inducing effect  is insufficient for classification in Category 2. Additional experiments would not be expected to  yield further relevant information with respect to classification;  (b)  substances which are insufficiently investigated. The available date are inadequate, but they  raise concern for man. This classification is provisional; further experiments are necessary before  a final decision can be made.  For a distinction between Categories 2 and 3 the arguments listed below are relevant which reduce  the significance of experimental tumour induction in view of possible human exposure. These  arguments, especially in combination, would lead in most cases to classification in Category 3,  even though tumours have been induced in animals:  -  carcinogenic effects only at very high dose levels exceeding the 'maximal tolerated dose`. The  maximal tolerated dose is characterized by toxic effects which, although not yet reducing lifespan,  go along with physical changes such as about 10  % retardation in weight gain,  -  appearance of tumours, especially at high dose levels, only in particular organs of certain  species known to be susceptible to a high spontaneous tumour formation,  -  appearance of tumours, only at the site of application, in very sensitive test systems (e.g.,  i.p. or s.c. application of certain locally active compounds), if the particular target is not  relevant to man,  -  lack of genotoxicity in short-term tests in vivo and in vitro,  -  existence of a secondary mechanism of action with the implication of a practical threshold  above a certain dose level (e.g., hormonal effets on target organs or on mechanisms of  physiological regulation, chronic stimulation of cell proliferation),  -  existence of a species - specific mechanism of tumour formation (e.g. by specific metabolic  pathways) irrelevant for man.  For a distinction between Category 3 and no classification arguments are relevant which exclude a  concern for man:  -  a substance should not be classified in any of the categories if the mechanism of experimental  tumour formation is clearly identified, with good evidence that this process cannot be extrapolated  to man,  -  if the only available tumour data are liver tumours in certain sensitive strains of mice,  without any other supplementary evidence, the substance may not be classified in any of the  categories,  -  particular attention should be paid to cases where the only available tumour data are the  occurrence of neoplasms at sites and in strains where they are well known to occur spontaneously  with a high incidence. 4.2.2. Mutagenic substances 4.2.2.1. For the purposes of classification and labelling, and having regard to the current state  of knowledge, such substances are divided into three categories:  Category 1  Substances known to be mutagenic to man.  There is sufficient evidence to establish a causal association between human exposure to a  substance and heritable genetic damage.  Category 2  Substances which should be regarded as if they are mutagenic to man.  There is sufficient evidence to provide a strong presumption that human exposure to the substance  may result in the development of heritable genetic damage, generally on the basis of:  -  appropriate animal studies,  -  other relevant information.  Category 3  Substances which cause concern for man owing to possible mutagenic effects. There is evidence from  appropriate mutagenicity studies, but this is insufficient to place the substance in Category 2. 4.2.2.2. The following symbols and specific risk phrases apply:  Category 1:  T; R46 May cause heritable genetic damage  Category 2:  T; R46 May cause heritable genetic damage  Category 3:  Xn; R40 Possible risk of irreversible effects 4.2.2.3. Comments regarding the categorisation of mutagenic substances  Definition of terms:  A mutation is a permanent change in the amount or structure of the genetic material in an  organism, resulting in a change of the phenotypic characteristics of the organism. The alterations  may involve a single gene, a block of genes, or a whole chromosome. Effects involving single genes  may be a consequence of effects on single DNA bases (point mutations) or of large changes,  including deletions, within the gene. Effects on whole chromosomes may involve structural or  numerical changes. A mutation in the germ cells in sexually reproducing organisms may be  transmitted to the offspring. A mutagen is an agent that gives rise to an enhanced occurrence of  mutations.It should be noted that substances are classified as mutagens with specific reference to inherited  genetic damage. However, the type of results leading to classification of chemicals in Category 3:  'induction of genetically relevant events in somatic cells`, is generally also regarded as an alert  for possible carcinogenic activity.  Method development for mutagenicity testing is an ongoing process. For many new tests no  standardized protocols and evaluation criteria are presently available. For the evaluation of  mutagenicity data the quality of the test performance and the degree of validation of the test  method have to be considered.  Category 1  To place a substance in Category 1, positive evidence from human mutation epidemiology studies  will be needed. Examples of such substances are not known to date. It is recognized that it is  extremely difficult to obtain reliable information from studies on the incidence of mutations in  human populations, or on possible increases in their frequencies.  Category 2  To place a substance in Category 2, positive results are needed from assays showing (a) mutagenic  effects, or (b) other cellular interactions relevant to mutagenicity, in germ cells of mammals in  vivo, or (c) mutagenic effects in somatic cells of mammals in vivo in combination with clear  evidence that the substance or a relevant metabolite reaches the germ cells.  With respect to placement in Category 2, at present the following methods are appropriate:  2  (a)  in vivo germ cell mutagenicity assays:  -  specific locus mutation test,  -  heritable translocation test,  -  dominant lethal mutation test.  These assays actually demonstrate the appearance of affected progeny or a defect in the developing  embryo.  2  (b)  in vivo assays showing relevant interaction with germ cells (usually DNA): -  assays for chromosomal abnormalities, as detected by cytogenetic analysis, including aneuploidy,  caused by malsegregation of chromosomes, -  test for sister chromatid exchanges (SCEs), -  test for unscheduled DNA synthesis (UDS), -  assay of (covalent) binding of mutagen to germ cell DNA, -  assaying other kinds of DNA damage. These assays provide evidence of a more or less indirect  nature. Positive results in these assays would normally be supported by positive results from in  vivo somatic cell mutagenicity assays, in mammals or in man (see under Category 3, preferably  methods as under 3 (a)). 2  (c)  in vitro assays showing mutagenic effects in somatic cells of  mammals (see under 3  (a)), in combination with toxicokinetic methods, or other methodologies  capable of demonstrating that the compound or a relevant metabolite reaches the germ cells. For 2   (b) and 2  (c), positive results from host-mediated assays or the demonstration of unequivocal  effects in in vitro assays can be considered as supporting evidence. Category 3 To place a  substance in Category 3, positive results are needed in assays showing (a) mutagenic effects or (b)  other cellular interaction relevant to mutagenicity, in somatic cells in mammals in vivo. The  latter especially would normally be supported by positive results from in vitro mutagenicity  assays. For effects in somatic cells in vivo at present the following methods are appropriate: 3   (a)  in vivo somatic cell mutagenicity assays: -  bone marrow micronucleus test or metaphase analysis, -  metaphase analysis of peripheral lymphocytes, -  mouse coat colour spot test. 3  (b)  in vivo somatic cell DNA interaction assays: -  test for SCEs in somatic cells, -  test for UDS in somatic cells, -  assay for the (covalent) binding of mutagen to somatic cell DNA, -  assay for DNA damage, e.g. by alkaline elution, in somatic cells. Substances showing positive  results only in one or more in vitro mutagenicity assays should normally not be classified. Their  further investigation using in vivo assays, however, is strongly indicated. In exceptional cases,  e.g. for a substance showing pronounced responses in several in vitro assays, for which no relevant  in vivo data are available, and which shows resemblance to known mutagens/carcinogens,  classification in Category 3 could be considered. 4.2.3. Substances toxic to reproduction 4.2.3.1. For the purposes of classification and labelling and having regard to the present state of  knowledge, such substances are divided into 3 categories:  Category 1:  Substances known to impair fertility in humans  There is sufficient evidence to establish a causal relationship between human exposure to the  substance and impaired fertility.  Substances known to cause developmental toxicity in humans  There is sufficient evidence to establish a causal relationship between human exposure to the  substance and subsequent developmental toxic effects in the progeny.  Category 2  Substances which should be regarded as if they impair fertility in humans  There is sufficient evidence to provide a strong presumption that human exposure to the substance  may result in impaired fertility on the basis of:  -  clear evidence in animal studies of impaired fertility in the absence of toxic effects, or,  evidence of impaired fertility occurring at around the same dose levels as other toxic effects but  which is not a secondary non-specific consequence of the other toxic effects,  -  other relevant information.  Substances which should be regarded as if they cause developmental toxicity to humans  There is sufficient evidence to provide a strong presumption that human exposure to the substance  may result in developmental toxicity, generally on the basis of:  -  clear results in appropriate animal studies where effects have been observed in the absence of  signs of marked maternal toxicity, or at around the same dose levels as other toxic effects but  which are not a secondary non-specific consequence of the other toxic effects,  -  other relevant information.  Category 3  Substances which cause concern for human fertility  Generally on the basis of:  -  results in appropriate animal studies which provide sufficient evidence to cause a strong  suspicion of impaired fertility in the absence of toxic effects, or evidence of impaired fertility  occuring at around the same dose levels as other toxic effects, but which is not a secondary  non-specific consequence of the other toxic effects, but where the evidence is insufficient to  place the substance in Category 2,  -  other relevant information.  Substances which cause concern for humans owing to possible developmental toxic effects  Generally on the basis of:  -  results in appropriate animal studies which provide sufficient evidence to cause a strong  suspicion of developmental toxicity in the absence of signs of marked maternal toxicity, or at  around the same dose levels as other toxic effects but which are not a secondary non-specific  consequence of the other toxic effects, but where the evidence is insufficient to place the  substance in Category 2,  -  other relevant information. 4.2.3.2. The following symbols and specific risk phrases apply:  Category 1:  for substances that impair fertility in humans:  T; R60: May impair fertility  for substances that cause developmental toxicity:  T; R61: May cause harm to the unborn child  Category 2:  for substances that should be regarded as if they impair fertility in humans:  T; R60: May impair fertility  for substances that should be regarded as if they cause developmental toxicity in humans:  T; R61: May cause harm to the unborn child.  Category 3:  for substances which cause concern for human fertility:  Xn; R62: Possible risk of impaired fertility  for substances which cause concern for humans owing to possible developmental toxic effects:  Xn; R63: Possible risk of harm to the unborn child. 4.2.3.3. Comments regarding the categorization of substances toxic to reproduction  Reproductive toxicity includes impairment of male and female reproductive functions or capacity  and the induction of non-inheritable harmful effects on the progeny. This may be classified under  two main headings of 1. Effects on male or female fertility; 2. Developmental toxicity.  1  Effects on male or female fertility, includes adverse effects on libido, sexual behaviour, any  aspect of spermatogenesis or oogenesis, or on hormonal activity or physiological response which  would interfere with the capacity to fertilise, fertilisation itself or the development of the  fertilised ovum up to and including implantation.  2  Developmental toxicity, is taken in its widest sense to include any effect interfering with  normal development, both before and after birth. It includes effects induced or manifested  prenatally as well as those manifested postnatally. This includes embrytoxic/fetotoxic effects such  as reduced body weight, growth and developmental retardation, organ toxicity, death, abortion,  structural defects (teratogenic effects), functional defects, peri-postnatal defects, and impaired  postnatal mental or physical development up to and including normal pubertal development.  Classification of chemicals as toxic to reproduction is intended to be used for chemicals which  have an intrinsic or specific property to produce such toxic effects. Chemicals should not be  classified as toxic to reproduction where such effects are solely produced as a non-specific  secondary consequence of other toxic effects. Chemicals of most concern are those which are toxic  to reproduction at exposure levels which do not produce other signs of toxicity.  The placing of a compound in Category 1 for effects on fertility and/or developmental toxicity is  done on the basis of epidemiological data. Placing into Categories 2 or 3 is done primarily on the  basis of animal data. Data from in vitro studies, or studies on avian eggs, are regarded as  'supportive evidence` and would only exceptionally lead to classification in the absence of in vivo  data.  In common with most other types of toxic effect, substances demonstrating reproductive toxicity  will be expected to have a threshold below which adverse effects would not be demonstrated. Even  when clear effects have been demonstrated in animal studies the relevance for humans may be  doubtful because of the doses administered, for example, where effects have been demonstrated only  at high doses, or where marked toxicokinetic differences exist, or the route of administration is  inappropriate. For these or similar reasons it may be that classification in Category 3, or even no  classification, will be warranted.  Annex V to the Directive specifies a limit test in the case of substances of low toxicity. If a  dose level of at least 1000 mg/kg orally produces no evidence of effects toxic to reproduction,  studies at other dose levels may not be considered necessary. If data are available from studies  carried out with doses higher than the above limit dose, this data must be evaluated together with  other relevant data. Under normal circumstances it is considered that effects seen only at doses in  excess of the limit dose would not necessarily lead to classification as 'Toxic to reproduction`.  EFFECTS ON FERTILITY For the classification of a substance into Category 2 for impaired fertility,  there should normally be clear evidence in one animal species, with supporting evidence on  mechanism of action or site of action, or chemical relationship to other known anti-fertility  agents or other information from humans which would lead to the conclusion that effects would be  likely to be seen in humans. Where there are studies in only one species without other relevant  supporting evidence then classification in Category 3 may be appropriate. Since impaired fertility  may occur as a non-specific accompaniment to severe generalized toxicity or where there is severe  inanition, classification into Category 2 should only be made where there is evidence that there is  some degree of specificity of toxicity for the reproductive system. If it was demonstrated that  impaired fertility in animal studies was due to failure to mate, then for classification into  Category 2, it would normally be necessary to have evidence on the mechanism of action in order to  interpret whether any adverse effect such as alteration in pattern of hormonal release would be  likely to occur in humans. DEVELOPMENTAL TOXICITY For classification into Category 2 there should  be clear evidence of adverse effects in well conducted studies in one or more species. Since  adverse effects in pregnancy or postnatally may result as a secondary consequence of maternal  toxicity, reduced food or water intake, maternal stress, lack of maternal care, specific dietary  deficiencies, poor animal husbandry, intercurrent infections, and so on, it is important that the  effects observed should occur in well conducted studies and at dose levels which are not associated  with marked maternal toxicity. The route of exposure is also important. In particular, the  injection of irritant material intraperitoneally may result in local damage to the uterus and its  contents, and the results of such studies must be interpreted with caution and on their own would  not normally lead to classification. Classification into Category 3 is based on similar criteria as  for Category 2 but may be used where the experimental design has deficiencies which make the  conclusions less convincing, or where the possibility that the effects may have been due to  non-specific influences such as generalised toxicity cannot be excluded. In general, classification  in Category 3 or no category would be assigned on an ad hoc basis where the only effects recorded  are small changes in the incidences of spontaneous defects, small changes in the proportions of  common variants such as are observed in skeletal examinations, or small differences in postnatal  developmental assessments. Effects during lactation Substances which are classified as toxic to  reproduction and which also cause concern due to their effects on lactation should in addition be  labelled with R64 (see criteria in Section 3.2.8.). For the purpose of classification, toxic  effects on offspring resulting only from exposure via the breast milk, or toxic effects resulting  from direct exposure of children will not be regarded as 'Toxic to reproduction`, unless such  effects result in impaired development of the offspring. Substances which are not classified as  toxic to reproduction but which cause concern due to toxicity when transferred to the baby during  the period of lactation should be labelled with R64 (see criteria in Section 3.2.8.). This R-phrase  may also be appropriate for substances which affect the quantity or quality of the milk. R64  would  normally be assigned on the basis of : (a)  toxicokinetic studies that would indicate the  likelihood that the substance would be present in potentially toxic levels in breast milk; and/or  (b)  on the basis of results of one or two generation studies in animals which indicate the  presence of adverse effects on the offspring due to transfer in the milk; and/or (c)  on the basis  of evidence in humans indicating a risk to babies during the lactational period. Substances which  are known to accumulate in the body and which subsequently may be released into milk during  lactation may be labelled with R33 and R64. 4.2.4. Procedure for the classification of preparations  concerning specific effects on health  If a preparation contains one or more substances classified with respect to the criteria laid out  above, it must be classified according to the criteria referred to in Article 3 (5) (j) to (q) of  Directive 88/379/EEC (the limits of concentration are either in Annex I to Directive 67/548/EEC, or  in Annex I to Directive 88/379/EEC where the substance or substances under consideration do not  appear in Annex I or appear in it without concentration limits). 5. CLASSIFICATION ON THE BASIS OF ENVIRONMENTAL EFFECTS 5.1. Introduction  The primary objective of classifying substances dangerous for the environment is to alert the user  to the hazards these substances present to ecosystems. Although the present criteria refer to  aquatic ecosystems it is recognized that certain substances may simultaneously or alternatively  affect other ecosystems whose constituents may range from soil microflora and microfauna to  primates.  The criteria set out below follow directly from the test methods set out in Annex V in so far as  they are mentioned. The test methods required for the 'base set` referred to in Annex VII are  limited and the information derived from them may be insufficient for an appropriate  classification. Classification may require additional data derived from Level 1 (Annex VIII) or  other equivalent studies. Furthermore, classified substances may be subject to review in the light  of other new data.  For the purposes of classification and labelling and having regard to the current state of  knowledge such substances are divided into two groups according to their acute and/or long-term  effects in aquatic systems or their acute and/or long-term effects in non-aquatic systems. 5.2. Criteria for classification, indication of danger, choice of risk phrases 5.2.1. Aquatic environment 5.2.1.1. Substances shall be classified as dangerous for the environment and assigned the symbol  'N` and the appropriate indication of danger, and assigned risk phrases in accordance with the  following criteria:  R50:  Very toxic to aquatic organisms and  R53:  May cause long-term adverse effects in the aquatic environment  Acute toxicity:  96  hr  LC50  (for fish) &le; 1 mg/l   or 48  hr  EC50  (for Daphnia) &le; 1 mg/l   or 72  hr  IC50  (for algae) &le; 1 mg/l  and the substance is not readily degradable  or the log Pow (log octanol/water partition coefficient) &ge; 3,0 (unless the experimentally  determined BCF &le; 100)  R50: Very toxic to aquatic organisms  Acute toxicity:  96  hr  LC50  (for fish) &le; 1 mg/l   or 48  hr  EC50  (for Daphnia) &le; 1 mg/l   or 72  hr  IC50  (for algae) &le; 1 mg/l  R51:  Toxic to aquatic organisms and  R53:  May cause long-term adverse effects in the aquatic environment  Acute toxicity:  96  hr  LC50  (for fish) 1 mg/l < LC50 &le; 10 mg/l   or 48  hr  EC50  (for Daphnia) 1 mg/l < EC50 &le; 10 mg/l   or 72  hr  IC50  (for algae) 1 mg/l < IC50  &le; 10 mg/l  and the substance is not readily degradable or the log Pow &ge; 3,0 (unless the experimentally determined BCF &le; 100) 5.2.1.2. Substances shall be classified as dangerous for the environment in accordance with the  criteria set out below. Risk phrases shall also be assigned in accordance with the following  criteria  R52:  Harmful to aquatic organisms and  R53:  May cause long-term adverse effects in the aquatic environment  Acute toxicity:  96  hr  LC50  (for fish): 10 mg/l < LC50 &le; 100 mg/l   or 48  hr  EC50  (for Daphnia): 10 mg/l < EC50 &le; 100 mg/l   or 72  hr  IC50  (for algae): 10 mg/l < IC50 &le; 100 mg/l  and the substance is not readily degradable.  This criterion applies unless there exists additional scientific evidence concerning degradation  and/or toxicity sufficient to provide an adequate assurance that neither the substance nor its  degradation products will constitute a potential long-term and/or delayed danger to the aquatic  environment. Such additional scientific evidence should normally be based on the studies required  at Level 1 (Annex VIII), or studies of equivalent value, and could include:  (i)  a proven potential to degrade rapidly in the aquatic environment;  (ii)  an absence of chronic toxicity effects at a concentration of 1,0 mg/litre, e.g. a  no-observed effect concentration of greater than 1,0 mg/litre determined in a prolonged toxicity  study with fish or Daphnia.  R52:  Harmful to aquatic organisms Substances not falling under the criteria listed above in this chapter, but which on the basis of  the available evidence concerning their toxicity may nevertheless present a danger to the structure  and/or functioning of aquatic ecosystems.  R53:  May cause long-term adverse effects in the aquatic environment Substances not falling under the criteria listed above in this chapter, but which, on the basis of  the available evidence concerning their persistence, potential to accumulate, and predicted or  observed environmental fate and behaviour may nevertheless present a long-term and/or delayed  danger to the structure and/or functioning of aquatic ecosystems. For example, poorly water-soluble substances, i.e. substances with a solubility of less than 1 mg/l  will be covered by this criteria if: (a)  they are not readily degradable; and (b)  the log Pow &ge; 3,0 (unless the experimentally determined BCF &le; 100) This criterion applies unless there exists additional scientific evidence concerning degradation  and/or toxicity sufficient to provide an adequate assurance that neither the substance nor its  degradation products will constitute a potential long-term and/or delayed danger to the aquatic  environment.  Such additional scientific evidence should normally be based on the studies required at Level 1  (Annex VIII), or studies of equivalent value, and could include: (i)  a proven potential to degrade  rapidly in the aquatic environment; (ii)  an absence of chronic toxicity effects at the solubility  limit, e.g. a no-observed effect concentration of greater than the solubility limit determined in a  prolonged toxicity study with fish or Daphnia. 5.2.1.3. Comments on the determination of IC50 for  algae and of degradability.  -  Where it can be demonstrated in the case of highly coloured substances that algal growth is  inhibited solely as a result of a reduction in light intensity, then the 72h IC50 for algae should  not be used as a basis for classification.  -  Substances are considered readily degradable if the following criteria hold true:  (a)  If in 28-day biodegradation studies the following levels of degradation are achieved:  -  in tests based upon dissolved organic carbon: 70  %,  -  in tests based upon oxygen depletion or carbon dioxide generation: 60  % of the theoretical  maxima.  These levels of biodegradation must be achieved within 10 days of the start of degradation, which  point is taken as the time when 10  % of the substance has been degraded;  or  (b)  if in those cases where only COD and BOD5, data are available when the ratio of BOD5/COD is  greater than or equal to 0,5;  or  (c)  if other convincing scientific evidence is available to demonstrate that the substance can be  degraded (biotically and/or abiotically) in the aquatic environment to a level of > 70  % within a  28-day period. 5.2.2. Non - aquatic environment 5.2.2.1. Substances shall be classified as dangerous for the environment and assigned the symbol  'N` and the appropriate indication of danger, and assigned risk phrases in accordance with the  following criteria:  R54:  Toxic to flora  R55:  Toxic to fauna  R56:  Toxic to soil organisms  R57:  Toxic to bees  R58:  May cause long-term adverse effects in the environment  Substances which on the basis of the available evidence concerning their toxicity, persistence,  potential to accumulate and predicted or observed environmental fate and behaviour may present a  danger, immediate or long-term and/or delayed, to the structure and/or functioning of natural  ecosystems other than those covered under 5.2.1. above. Detailed criteria will be elaborated  later.  R59:  Dangerous for the ozone layer Substances which on the basis of the available evidence concerning their properties and their  predicted or observed environmental fate and behaviour may present a danger to the structure and/or  the functioning of the stratospheric ozone layer. This includes the substances which are listed in  Annex I Group I, II, III, IV and V to Council Regulation (EEC) No 594/91 on substances that deplete  the ozone layer (OJ No L 67, 14. 3. 1991, p. 1). 5.2.2.2. Substances shall be classified as dangerous for the environment in accordance with the  criteria set out below. Risk phrases shall also be assigned in accordance with the following  criteria:  R59:  Dangerous for the ozone layer  Substances not falling under the criteria listed above in 5.2.2.1. which on the basis of the  available evidence concerning their properties and their predicted or observed environmental fate  and behaviour may present a danger to the structure and/or the functioning of the stratospheric  ozone layer. This includes the substances which are listed in Annex I Group VI to Council  Regulation (EEC) No 594/91 on substances that deplete the ozone layer (OJ No L 67, 14. 3. 1991, p.  1).  6. CHOICE OF SAFETY ADVICE PHRASES 6.1. Introduction  Safety advice phrases (S-phrases) shall be assigned to dangerous substances and preparations in  accordance with the following general criteria. In addition, for certain preparations, the safety  advice listed in Annex II to Directive 88/379/EEC is mandatory.  Whenever the manufacturer is mentioned in Chapter 6 it refers to the person responsible for  placing the substance or preparation on the market. 6.2. Safety phrases for substances and preparations  S1  Keep locked up -  Applicability: -  very toxic, toxic and corrosive substances and preparations. -  Criteria for use: -  obligatory for those substances and preparations mentioned above if sold to the general public.  S2  Keep out of the reach of children -  Applicability: -  all dangerous substances and preparations. -  Criteria for use: -  obligatory for all dangerous substances and preparations sold to the general public, except for  those only classified as dangerous for the environment.  S3  Keep in a cool place -  Applicability: -  organic peroxides, -  other dangerous substances and preparations having a boiling point &le; 40  °C. -  Criteria for use: -  obligatory for organic peroxides unless S47 is used, -  recommended for other dangerous substances and preparations having a boiling point &le; 40  °C.  S4  Keep away from living quarters -  Applicability: -  very toxic and toxic substances and preparations. -  Criteria for use: -  normally limited to very toxic and toxic substances and preparations when desirable to  supplement S13; for example when there is an inhalation risk and the substance or preparation  should be stored away from living quarters. The advice is not intended to preclude proper use of  the substance or preparation in living quarters.  S5  Keep contents under .  .  . (appropriate liquid to be specified by the manufacturer) -  Applicability: -  spontaneously flammable solid substances and preparations. -  Criteria for use:- normally limited to special cases, e.g. sodium, potassium or white phosphorous.  S6  Keep under .  .  . (inert gas to be specified by the manufacturer) -  Applicability: -  dangerous substances and preparations which must be kept under an inert atmosphere. -  Criteria for use: -  normally limited to special cases, e.g. certain organo-metallic compounds.  S7  Keep container tightly closed -  Applicability: -  organic peroxides, -  substances and preparations which can give off very toxic, toxic, harmful or extremely flammable  gases, -  substances and preparations which in contact with moisture give off extremely flammable gases, -  highly flammable solids. -  Criteria for use: -  obligatory for organic peroxides, -  recommended for the other fields of application mentioned above.  S8  Keep container dry -  Applicability: -  substances and preparations which may react violently with water, -  substances and preparations which on contact with water liberate extremely flammable gases, -  substances and preparations which on contact with water liberate very toxic or toxic gases. -  Criteria for use: -  normally limited to the fields of application mentioned above when necessary to reinforce  warnings given by R14, R15 in particular, and R29.  S9  Keep container in a well-ventilated place -  Applicability: -  volatile substances and preparations which may give off very toxic, toxic or harmful vapours, -  extremely flammable or highly flammable liquids and extremely flammable gases. -  Criteria for use: -  recommended for volatile substances and preparations which may give off very toxic, toxic or  harmful vapours, -  recommended for extremely flammable or highly flammable liquids or extremely flammable gases.  S12  Do not keep the container sealed -  Applicability: -  substances and preparations which will by giving off gases or vapours be liable to burst the  container. -  Criteria for use: -  normally limited to the special cases mentioned above.  S13  Keep away from food, drink and animal feedingstuffs -  Applicability: -  very toxic, toxic and harmful substances and preparations. -  Criteria for use: -  recommended when such substances and preparations are likely to be used by the general public.  S14  Keep away from .  .  . (incompatible materials to be indicated by the manufacturer) -  Applicability: -  organic peroxides -  Criteria for use: -  obligatory for and normally limited to organic peroxides. However, may be useful in exceptional  cases when incompatibility is likely to produce a particular risk  S15  Keep away from heat -  Applicability: -  substances and preparations which may decompose or which may react spontaneously under the  effect of heat. -  Criteria for use: -  normally limited to special cases, e.g. monomers, but not assigned if risk phrases R2, R3 and/or  R5 have already been applied.  S16  Keep away from sources of ignition - No smoking -  Applicability: -  extremely flammable or highly flammable liquids and extremely flammable gases. -  Criteria for use: -  recommended for the substances and preparations mentioned above but not assigned if risk phrases  R2, R3 and/or R5 have already been applied.  S17  Keep away from combustible material -  Applicability: -  substances and preparations which may form explosive or spontaneously flammable mixtures with  combustible material. -  Criteria for use: -  available for use in special cases, e.g. to emphasize R8 and R9.  S18  Handle and open container with care -  Applicability: -  substances and preparations liable to produce an overpressure in the container, -  substances and preparations which may form explosive peroxides. -  Criteria for use: -  normally limited to the above-mentioned cases when there is risk of damage to the eyes and/or  when the substances and preparations are likely to be used by the general public.  S20  When using do not eat or drink -  Applicability: -  very toxic, toxic and corrosive substances and preparations. -  Criteria for use: -  normally limited to special cases (e.g. arsenic and arsenic compounds; fluoracetates) in  particular when any of these are likely to be used by the general public.  S21  When using do not smoke -  Applicability: -  substances and preparations which produce toxic products on combustion. -  Criteria for use: -  normally limited to special cases (e.g. halogenated compounds).  S22  Do not breathe dust -  Applicability: -  all solid substances and preparations dangerous for health. -  Criteria for use: -  obligatory for those substances and preparations mentioned above to which R42 is assigned, -  recommended for those substances and preparations mentioned above which are supplied in the form  of an inhalable dust and for which the health hazards following inhalation are not known.  S23  Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the  manufacturer) -  Applicability: -  all liquid or gaseous substances and preparations dangerous to health. -  Criteria for use: -  obligatory for those substances and preparations mentioned above to which R42 is assigned, -  obligatory for substances and preparations intended for use by spraying. Either S38 or S51 must  be ascribed in addition, -  recommended when it is necessary to draw the attention of the user to inhalation risks not  mentioned in the risk phrases which have to be ascribed.  S24  Avoid contact with skin -  Applicability: -  all substances and preparations dangerous for health. -  Criteria for use: -  obligatory for those substances and preparations to which R43 has been ascribed unless S36 has  also been ascribed, -  recommended when it is necessary to draw the attention of the user to skin contact risks not  mentioned in the risk phrases which have to be ascribed. However, may be used to emphasize such  risk phrases.  S25  Avoid contact with eyes -  Applicability: -  corrosive or irritant substances and preparations. -  Criteria for use: -  normally limited to special cases, i.e. when it is considered essential to emphasize the risk to  eyes denoted by use of R34, R35, R36 or R41. Thus important if these substances and preparations  are likely to be used by the general public and eye or face protection may not be available.  S26  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice -  Applicability: -  corrosive or irritant substances and preparations. -  Criteria for use: -  obligatory for corrosive substances and preparations and those to which R41 has already been  ascribed, -  recommended for irritant substances and preparations to which the risk phrase R36 has already  been ascribed.  S27  Take off immediately all contaminated clothing -  Applicability: -  very toxic, toxic or corrosive substances and preparations. -  Criteria for use: -  recommended for very toxic and toxic substances and preparations which are easily absorbed by  the skin and for corrosive substances and preparations. However, this safety phrase should not be  used if S36 has been ascribed. S28  After contact with skin, wash immediately with plenty of .  .   . (to be specified by the manufacturer) -  Applicability: -  very toxic, toxic or corrosive substances and preparations. -  Criteria for use: -  obligatory to very toxic substances and preparations, -  recommended for the other substances and preparations mentioned above, in particular when water  is not the most appropriate rinsing fluid. S29  Do not empty into drains -  Applicability: -  extremely or highly flammable liquids immiscible with water. -  Criteria for use: -  recommended for above mentioned substances and preparations which are likely to be used by the  general public. S30  Never add water to this product -  Applicability: -  substances and preparations which react violently with water. -  Criteria for use: -  normally limited to special cases (e.g. sulphuric acid) and may be used, as appropriate, to give  the clearest possible information, either to emphasize R14 or as an alternative to R14. S33  Take  precautionary measures against static discharges -  Applicability: -  extremely or highly flammable substances and preparations. -  Criteria for use: -  recommended for substances and preparations used in industry which do not absorb moisture.  Virtually never used for substances and preparations as placed on the market for use by the general  public. S35  This material and its container must be disposed of in a safe way -  Applicability: -  explosive substances and preparations, -  very toxic and toxic substances and preparations, -  substances dangerous for the environment. -  Criteria for use: -  obligatory for explosive substances and preparations other than organic peroxides, -  recommended for very toxic and toxic substances and preparations, particularly when likely to be  used by the general public, -  recommended for substances dangerous for the environment for which S56 does not apply when such  substances are likely to be used by the general public. S36  Wear suitable protective clothing -  Applicability: -  organic peroxides, -  very toxic, toxic or harmful substances and preparations, -  corrosive substances and preparations. -  Criteria for use: -  obligatory for very toxic and corrosive substances and preparations, -  obligatory for those substances and preparations to which either R21 or R24 has been ascribed, -  obligatory for category 3 carcinogens, mutagens and substances toxic to reproduction unless the  effects are produced solely by inhalation of the substance or preparation, -  obligatory for organic peroxides, -  recommended for toxic substances and preparations if the LD50 dermal value is unknown but the  substance or preparation is likely to be toxic through skin contact, -  recommended for substances and preparations used in industry which are liable to damage health  by prolonged exposure. S37  Wear suitable gloves -  Applicability: -  very toxic, toxic, harmful or corrosive substances and preparations, -  organic peroxides, -  substances and preparations irritating to the skin. -  Criteria for use: -  obligatory for very toxic and corrosive substances and preparations, -  obligatory for those substances and preparations to which either R21, R24 or R43 has been  ascribed, -  obligatory for Category 3 carcinogens, mutagens and substances toxic to reproduction unless the  effects are produced solely by inhalation of the substance or preparation, -  obligatory for organic peroxides, -  recommended for toxic substances and preparations if the LD50 dermal value is unknown but the  substance or preparation is likely to be toxic through skin contact, -  recommended for substances and preparations which are irritating to the skin because of their  defatting properties. S38  In case of insufficient ventilation wear suitable respiratory equipment -  Applicability: -  very toxic or toxic substances and preparations. -  Criteria for use: -  normally limited to special cases involving the use of very toxic or toxic substances and  preparations in industry or in agriculture. S39  Wear eye/face protection -  Applicability: -  organic peroxides, -  corrosive substances and preparations, including irritants which give rise to risk of serious  damage to the eyes, -  very toxic and toxic substances and preparations. -  Criteria for use: -  obligatory for those substances and preparations to which R34, R35 or R41 have been ascribed, -  obligatory for organic peroxides, -  recommended when it is necessary to draw the attention of the user to eye contract risks not  mentioned in the risk phrases which have be to ascribed, -  normally limited to exceptional cases for very toxic and toxic substances and preparations,  where there is a risk of splashing and they are likely to be easily absorbed by the skin. S40  To  clean the floor and all objects contaminated by this material use  .  .  . (to be specified by the  manufacturer) -  Applicability: -  all dangerous substances and preparations. -  Criteria for use: -  normally limited to those dangerous substances and preparations for which water is not  considered to be a suitable cleansing agent (e.g. where absorption by powdered material,  dissolution by solvent etc. is necessary) and where it is important for health and/or safety  reasons to provide a warning on the label. S41  In case of fire and/or explosion do not breathe  fumes -  Applicability: -  dangerous substances and preparations which on combustion give off very toxic or toxic gases. -  Criteria for use: -  normally limited to special cases S42  During fumigation/spraying wear suitable respiratory  equipment (appropriate wording to be specified by the manufacturer) -  Applicability: -  substances and preparations intended for such use but which may endanger the health and safety  of the user unless proper precautions are taken. -  Criteria for use: -  normally limited to special cases. S43  In case of fire use  .  .  . (indicate in the space the  precise type of fire-fighting equipment. If water increases the risk add: Never use water) -  Applicability: -  extremely flammable, highly flammable and flammable substances and preparations. -  Criteria for use: -  obligatory for substances and preparations which, in contact with water or damp air, evolve  extremely flammable gases, -  recommended for extremely flammable, highly flammable and flammable substances and preparations,  particularly when they are immiscible with water. S45  In case of accident or if you feel unwell  seek medical advice immediately (show the label where possible) -  Applicability: -  very toxic substances and preparations, -  toxic and corrosive substances and preparations. -  Criteria for use: -  obligatory for the substances and preparations mentioned above. S46  If swallowed, seek medical  advice immediately and show this container or label -  Applicability: -  all dangerous substances and preparations other than those which are very toxic, toxic,  corrosive or dangerous to the environment. -  Criteria for use: -  obligatory for all dangerous substances and preparations mentioned above which are likely to be  used by the general public, unless there is no reason to fear any danger from swallowing,  particularly by children. S47  Keep at temperature not exceeding  .  .  .  °C (to be specified by  the manufacturer) -  Applicability: -  substances and preparations which become unstable at a certain temperature. -  Criteria for use: -  normally limited to special cases (e.g. certain organic peroxides). S48  Keep wetted with .  .   .  .  (appropriate material to be specified by the manufacturer) -  Applicability: -  substances and preparations which may become very sensitive to sparks, friction or impact if  allowed to dry out. -  Criteria for use: -  normally limited to special cases, e.g. nitrocelluloses. S49  Keep only in the original  container -  Applicability: -  substances and preparations sensitive to catalytic decomposition. -  Criteria for use: -  substances and preparations sensitive to catalytic decomposition e.g. certain organic peroxides.  S50  Do not mix with .  .  .  (to be specified by the manufacturer) -  Applicability: -  substances and preparations which may react with the specified product to evolve very toxic or  toxic gases, -  organic peroxides. -  Criteria for use: -  recommended for substances and preparations mentioned above which are likely to be used by the  general public, when it is a better alternative to R31 or R32, -  obligatory with certain peroxides which may give violent reaction with accelerators or  promoters. S51  Use only in well-ventilated areas -  Applicability: -  substances and preparations likely to or intended to produce vapours, dusts, sprays, fumes,  mists, etc. which give rise to inhalation risks or to a fire or explosion risk. -  Criteria for use: -  recommended when use of S38 would not be appropriate. Thus important when such substances and  preparations are likely to be used by the general public. S52  Not recommended for interior use on  large surface areas -  Applicability: -  volatile, very toxic, toxic and harmful substances and preparations containing them. -  Criteria for use: -  recommended when damage to health is likely to be caused by prolonged exposure to these  substances by reason of their volatilization from large treated surfaces in the home or other  enclosed places where persons congregate. S53  Avoid exposure - Obtain special instructions before  use -  Applicability: -  substances and preparations that are carcinogenic, mutagenic and/or toxic to reproduction. -  Criteria for use: -  obligatory for the abovementioned substances and preparations to which at least one of the  following R-phrases has been assigned: R45, R46, R49, R60 or R61. S56  Dispose of this material and  its container to hazardous or special waste collection point. -  Applicability: -  substances dangerous for the environment. -  Criteria for use: -  recommended for substances which have been assigned the symbol 'N` and likely to be used by the  general public. S57  Use appropriate containment to avoid environmental contamination -  Applicability: -  substances which have been assigned the symbol 'N`. -  Criteria for use: -  normally limited to substances not likely to be used by the general public. S59  Refer to  manufacturer/supplier for information on recovery/recycling -  Applicability: -  substances dangerous for the environment. -  Criteria for use: -  obligatory for substances dangerous for the ozone layer, -  recommended for other substances assigned the symbol 'N` and for which recovery/recycling is  recommended. S60  This material and its container must be disposed of as hazardous waste -  Applicability: -  substances dangerous for the environment. -  Criteria for use: -  recommended for substances which have been assigned the symbol 'N` not likely to be used by the  general public. S61  Avoid release to the environment. Refer to special instructions/Safety data  sheet -  Applicability: -  substances dangerous for the environment. -  Criteria for use: -  normally used for substances which have been assigned the symbol 'N`, -  recommended for all substances classified dangerous for the environment not covered above. S62   If swallowed, do not induce vomiting: seek medical advice immediately and show this container or  label -  Applicability: -  liquid substances and preparations having a kinematic viscosity measured by means of rotational  viscometry in accordance with ISO standard 3219 or equivalent method that is less than 7  x   10-6m2/sec at 40  °C and containing aliphatic, alicyclic and/or aromatic hydrocarbons in a total  concentration equal to or greater than 10  %, -  not applicable to substances and preparations which are placed on the market in aerosol  containers. -  Criteria for use: -  obligatory for substances and preparations mentioned above, if sold to, or likely to be used by  the general public, -  recommended for the substances and preparations mentioned above when used in industry.  7. LABELLING 7.1. When a substance or preparation has been classified the appropriate label is determined with  reference, to the requirements of Article 23 of Directive 67/548/EEC and Article 7 of Directive  88/379/EEC for substances and preparations respectively. This section explains how the label is  determined and, in particular, gives guidance on how to choose the appropriate risk and safety  phrases.  The label contains the following information:  (a)  name or names of the substances which will appear on the label;  (b)  the name, address and telephone number of the manufactured/importer;  (c)  the symbols and indication of danger;  (d)  phrases indicating particular risks (R-phrases);  (e)  phrases indicating safety advice (S-phrases);  (f)  for substances, the EEC number. 7.1.1. For substances appearing in Annex I to Directive 67/548/EEC, the label also includes the  words 'EEC label`. 7.1.2. Final choice of risk and safety phrases  Although the final choice of the most appropriate risk and safety phrases is primarily governed by  the need to give all necessary information, consideration should also be given in the clarity and  impact of the label. With clarity in mind, the necessary information should be expressed in a  minimum number of phrases.  In the case of irritant, highly flammable, flammable and oxidizing substances and preparations, an  indication of R-phrases and S-phrases need not be given where the package does not contain more  than 125 ml. This shall also apply in the case of the same volume of harmful substances not  retailed to the general public. 7.1.3. Indications such as 'non-toxic`, 'non-harmful` or any other similar indications must not  appear on the label or packaging of substances or preparations subject to Directives 67/548/EEC and  88/379/EEC. 7.1.4. For certain preparations, Annex II of Directive 88/379/EEC has special provisions concerning  the labelling. 7.2. Chemical name(s) to be displayed on the label: 7.2.1. For substances listed in Annex I of Directive 67/548/EEC the label shall show the name of  the substances under one of the designations given in Annex I.  For substances not listed in Annex I, the name is established according to an internationally  recognized chemical nomenclature as defined in section 1.4 above. 7.2.2. For preparations, the choice of the names to be displayed on the label follows the rules of  Article 7 (1) (c) of Directive 88/379/EEC.  Note:  In the case of concentrate preparations which are intended for the perfume industry:  -  the person responsible for placing them on the market may identify merely the one sensitizing  substance judged by him to be primarily responsible for the sensitization hazard,  -  in the case of a natural substance, the chemical name may be of the type: 'essential oil of .   .  .`, 'extract of .  .  .`, rather than the name of the constituents of that essential oil or  extract. 7.3. Choice of danger symbols  The design of the danger symbols and the wording of the indications of danger shall comply with  those laid down in Annex II. The symbol shall be printed in black on an orange-yellow background. 7.3.1. For substances appearing in Annex I the danger symbols and indications of danger shall be  those shown in the Annex. 7.3.2. For dangerous substances not yet appearing in Annex I and for preparations, the danger  symbols and indications of danger shall be assigned according to the rules laid down in this  Annex.  When more than one danger symbol is assigned to a substance:  -  the obligation to indicate the symbol T makes the symbols X and C optional,  -  the obligation to indicate the symbol C makes the symbol X optional,  -  the obligation to indicate the symbol E makes the symbols F and O optional. 7.4. Choice of Risk-phrases  The wording of the R-phrases shall comply with that laid down in Annex III of Directive  67/548/EEC.  The combined R-phrases in Annex III shall be used where applicable. 7.4.1. For substances appearing in Annex I, the R-phrases shall be those shown in the Annex. 7.4.2. For substances not appearing in Annex I, R-phrases will be selected according to the  following criteria and priorities:  (a)  in the case of dangers which give rise to health effects:  (i)  R-phrases corresponding to the category of danger illustrated by a symbol must appear on the  label;  (ii)  R-phrases corresponding to other categories of danger which are not illustrated by a symbol  by virtue of Article 23 of Directive 67/548/EEC;  (b)  in the case of danger arising from physico-chemical properties:  -  the criteria described under 7.4.2 (a) above are applicable, except that the risk phrases  'extremely flammable` or 'highly flammable` need not be indicated where they repeat the wording of  the indication of danger used with a symbol;  (c)  in the case of danger for the environment:  -  the R-phrases corresponding to the classification category 'dangerous for the environment` must  appear on the label. 7.4.3. For preparations, R-phrases will be selected according to the following criteria and  priorities:  (a)  in the case of dangers which give rise to health effects:  (i)  R-phrases which correspond to the category of danger illustrated by a symbol. In certain  cases the R-phrases must be adopted according to the tables of Annex I to Directive 88/379/EEC.  More specifically, the R-phrases of the constituent(s) which are responsible for the assignment of  the preparation to a danger category must appear on the label;  (ii)  R-phrases which correspond to the other categories of danger which have been attributed to  the constituents but which are not illustrated by a symbol by virtue of Article 7 (d) of Directive  88/379/EEC;  (b)  in the case of dangers arising from physico-chemical properties:  -  the criteria described under 7.4.3 (a) are applicable, except that the risk phrases 'extremely  flammable` or 'highly flammable` need not be indicated where they repeat the wording of the  indication of danger used with a symbol.As a general rule, for preparations a maximum of four R-phrases shall suffice to describe the  risk; for this purpose the combined phrases listed in Annex III shall be regarded as single  phrases. However, the standard phrases must cover all the principal hazards associated with the  preparation.  However, if the manufacturer feels there is a need to identify environmental hazards, additional  R-phrases shall be added as required. 7.5. Safety phrases  The wording of the S-phrases shall comply with that laid down in Annex IV of Directive  67/548/EEC.  The combined S-phrases in Annex IV shall be used where applicable. 7.5.1. For substances appearing in Annex I, the S-phrases shall be those shown in the Annex. Where  no S-phrases are shown, the manufacturer/importer may include any appropriate S-phrase(s). 7.5.2. Choice of safety phrases  The final choice of safety phrases must have regard to the risk phrases indicated on the label and  to the intended use of the substance or preparation:  -  as a general rule, a maximum of four S-phrases shall suffice to formulate the most appropriate  safety advice; for this purpose the combined phrases listed in Annex IV shall be regarded as single  phrases,  -  in the case of danger to the environment a minimum of one and a maximum of four S-phrases  should be used,  -  some R-phrases become superfluous if a careful selection is made of S-phrases and vice-versa;  S-phrases which obviously correspond to R-phrases will appear on the label only if it is intended  to emphasize a specific warning,  -  particular attention must be given, in the choice of safety phrases, to the foreseen conditions  of use of certain substances and preparations, e.g. spraying or other aerosol effects. Phrases  should be chosen with the intended use in view,  -  the safety phrases S1, S2 and S45 are obligatory for all very toxic, toxic and corrosive  substances and preparations sold to the general public,  -  the safety phrases S2 and S46 are obligatory for all other dangerous substances (except those  only classified as dangerous for the environment) and preparations sold to the general public.  7.6. The EEC number  If a substance named on the label is listed in the European Inventory of Existing Commercial  Chemical Substances (Einecs) or in the European List of Notified Substances (Elincs), the Einecs or  Elincs number of the substances shall be shown on the Label. This requirement does not apply to  preparations. 8. SPECIAL CASES: SUBSTANCES 8.1. Mobile gas cylinders  For mobile gas cylinders the requirements concerning labelling are considered to be satisfied when  they are in agreement with Article 23 or Article 24 (6) b of Directive 67/548/EEC.  However, by way of derogation from Article 24 (1) and (2), one of the following alternatives can  be used for gas cylinders with a water capacity of less than or equal to 150 litres:  -  the format and dimensions of the label can follow the prescriptions of the ISO Standard ISO/DP  7225,  -  the information specified in Article 23 (2) may be provided on a durable information disc or  label held captive on the cylinder. 8.2. Metals in massive form  These substances are classified in Annex I to Directive 67/548/EEC or shall be classified in  accordance with Article 6 of Directive 67/548/EEC. However, some of these substances although  classified in accordance with Article 2 of Directive 67/548/EEC do not present a danger to human  health by inhalation, ingestion or contact with skin in the form in which they are placed on the  market. Such substances do not require a label according to Article 23 of this Directive. However,  all the information which should have appeared on the label shall be transmitted to the user by the  person responsible for placing the metal on the market, in a format foreseen in Article 26 of the  abovementioned Directive. 9. SPECIAL CASES: PREPARATIONS 9.1. Gaseous preparations (gas mixtures)  For gaseous preparations, consideration must be given to:  -  the evaluation of the physico-chemical properties,  -  the evaluation of health hazards. 9.1.1. Evaluation of physico-chemical properties 9.1.1.1. Flammability  The flammable properties of these preparations are determined in accordance with Article 3 (2) of  Directive 88/379/EEC according to the methods specified in Part A of Annex V to Directive  67/548/EEC.  These preparations will be classified according to the results of the tests carried out and with  respect to the criteria of Annex V and to the criteria of the labelling guide.  However, by derogation, in the case where gaseous preparations are produced to order in small  amounts, the flammability of these gaseous mixtures can be evaluated by the following calculation  method:  the expression of the gaseous mixture  A1F1  +  .  .  .  +  AiFi  +  .  .  .  AnFn  +  B1I1  +  .  .  .  +  BiIi  +  .  .  .  BpIp  where:  Ai and Bi are the molar fractions Fi flammable gas Ii inert gas n number of flammable gases p number of inert gases  can be transformed in a form where all the Ii (inert gases) are expressed by a nitrogen equivalent  using a coefficient Ki and where the equivalent content of inflammable gas A&prime;i is expressed  as follows:   A&prime;i = Ai × ( 100 (Ai+KiBi) )  By using the value of the maximum content of flammable gas which, in a mixture with nitrogen,  gives a composition which is not flammable in air (Tci), the following expression can be obtained:   Ói A&prime;i/Tci 1  The gas mixture is flammable if the value of the above expression is greater than one. The  preparation is classified extremely flammable and, the phrase R12 is assigned.  Coefficients of equivalency (K  i)  The values of the coefficients of equivalency Ki, between the inert gases and nitrogen and the  values of the maximum contents of flammable gas (Tci) may be found in tables 1 and 2 of the ISO  Standard ISO 10156 edition 15. 12. 1990.  Maximum content of flammable gas (Tci)  The value of the maximum content of flammable gas (Tci) may be found in table 2 of the ISO  Standard ISO 10156 edition 15. 12. 1990.  When a Tci value for a flammable gas does not appear in the above standard, the corresponding  lower explosivity limit (LEL) will be used. If no LEL value exists, the value of Tci will be set at  1  % by volume.  Remarks  -  The expression above can be used to allow an appropriate labelling of gaseous preparations,  however, it should not be regarded as a method for replacing experimentation for the determination  of technical safety parameters.  -  Furthermore, this expression gives no information as to whether a mixture containing oxidizing  gases can be prepared safely. When estimating flammability these oxidizing gases are not taken into  account.  -  The expression above will give reliable results only if the flammable gases do not influence  each other as far as their flammability is concerned. This has to be considered, e.g. with  halogenated hydrocarbons. 9.1.1.2. Oxidizing properties  Given the fact that Annex V to Directive 67/548/EEC does not contain a method to determine the  oxidizing properties of gaseous mixtures, the evaluation of these properties must be realised  according to the following estimation method.  The principle of the method is comparison of the oxidizing potential of gases in a mixture with  that of the oxidizing potential of oxygen in air. The concentrations of gases in the mixture are  expressed in % vol.  It is considered that the gas mixture is as oxidant as or more oxidant than air, if the following  condition is verified:   Ói xiCi &ge; 21  where:  xi is the concentration of gas i in % vol, Ci is the coefficient of oxygen equivalency.  In this case, the preparation is classified as oxidizing and the phrase R8 will be assigned.  Coefficients of equivalency between oxidizing gases and oxygen  The coefficients used in the calculation to determine the oxidizing capacity of certain gases in a  mixture with respect to the oxidizing capacity of oxygen in air, listed under 5.2. in the ISO  Standard ISO 10156 edition 15. 12. 1990, are the following.O2 1     N2O 0,6  When no value for the Ci coefficient exists for a gas in the cited standard a value of 40 is  attributed to this coefficient. 9.1.2. Evaluation of the health effects  This evaluation of the dangers of a preparation for health is made according to Article 3 (3) of  Directive 88/379/EEC.  When the evaluation of the health hazards is made according to the conventional method described  in Article 3 (5) of Directive 88/379/EEC by reference to individual concentration limits, the  individual concentration limits to be used are expressed in per cent by volume and appear:  -  either in Annex I to Directive 67/548/EEC for the gas(es) considered,  -  or in Annex I to Directive 88/379/EEC tables I A to VI A when the gas(es) considered are not in  Annex I, or appear there without concentration limits. 9.1.3 Labelling  For mobile gas holders the requirements concerning labelling are considered to be satisfied when  they are in agreement with Article 8 (5) (b) of Directive 88/379/EEC.  However, by way of derogation from Articles 8 (1) and 8 (2), for gas cylinders with a water  capacity of less than or equal to 150 litres, the format and dimensions of the label can follow the  prescriptions of the ISO Standard ISO/DP 7225. In this case, the label can bear the generic name or  industrial/commercial name of the preparation provided that the dangerous component substances of  the preparation are shown on the body of the gas cylinder in a clear and indelible way. 9.2. Alloys, preparations containing polymers, preparations containing elastomers  These preparations shall be classified according to the requirements of Article 3 and labelled  according to the requirements of Article 7 of Directive 88/379/EEC.  However some of these preparations although classified in accordance with Article 3 (3) do not  present a danger to human health by inhalation, ingestion or contact with skin in the form in which  they are placed on the market. Such preparations do not require a label according to Article 7;  however all the information which would have appeared on the label shall be transmitted to the  professional user by means of an information system in a format foreseen in Article 10 of the  abovementioned Directive. 9.3. Organic peroxides  Organic peroxides combine the properties of an oxidizer and a combustible substance in one  molecule: when an organic peroxide decomposes, the oxidizing part of the molecule reacts  exothermically with the combustible (oxidizable) part. For the oxidizing properties the existing  methods in Annex V cannot be applied to the organic peroxides.  The following calculation method based on the presence of active oxygen must be used.  The available oxygen content (%) of an organic peroxide preparation is given by the formula:  16 x (ni x ci/mi)  where:  ni = number of peroxygen groups per molecule of organic peroxide i,  ci = concentration (mass %) of organic peroxide i,  mi = molecular mass of organic peroxide i.  COMMISSION STATEMENT With regard to Section 4.1.5., and in particular to the last paragraph of  Section 4.1.5., the Commission states that, should it envisage making use of the procedure of  Article 28 of Directive 67/548/EEC, it is prepared to consult in advance appropriate experts  designated by Members States and having special qualifications with respect to either  carcinogenicity, mutagenicity or reproductive toxicity. This consultation will take place in the framework of the normal consultation procedure with  national experts and/or in the framework of existing committees. The same will be the case when  substances already included in Annex I must be reclassified in respect of their carcinogenic,  mutagenic effects, or effects toxic to reproduction.