CELEX: 32022R0692
Language: en
Date: 2022-02-16 00:00:00
Title: Commission Delegated Regulation (EU) 2022/692 of 16 February 2022 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (Text with EEA relevance)

3.5.2022   
               
               
                  EN
               
               
                  Official Journal of the European Union
               
               
                  L 129/1
               
            
         COMMISSION DELEGATED REGULATION (EU) 2022/692
         of 16 February 2022
         amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures
         (Text with EEA relevance)
         THE EUROPEAN COMMISSION,
         Having regard to the Treaty on the Functioning of the European Union,
         Having regard to Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (1), and in particular Article 37(5) thereof,
         Whereas:
         
                     (1)
                  
                  
                     Table 3 of Part 3 of Annex VI to Regulation (EC) No 1272/2008 contains the list of harmonised classification and labelling of hazardous substances based on the criteria set out in Parts 2 to 5 of Annex I to that Regulation.
                  
               
                     (2)
                  
                  
                     Proposals to introduce harmonised classification and labelling of certain substances and to update or delete the harmonised classification and labelling of certain other substances have been submitted to the European Chemicals Agency (the ‘Agency’) pursuant to Article 37 of Regulation (EC) No 1272/2008. The Committee for Risk Assessment of the Agency (RAC) adopted, after having taken account of the comments received from the parties concerned, the following opinions (2) on those proposals:
                     
                                 —
                              
                              
                                 Opinion of 5 December 2019 concerning silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica; pyrogenic, synthetic amorphous, nano, surface treated silicon dioxide;
                              
                           
                                 —
                              
                              
                                 Opinion of 4 May 2020 concerning cyfluthrin (ISO); α-cyano-4-fluoro-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate;
                              
                           
                                 —
                              
                              
                                 Opinion of 4 May 2020 concerning beta-cyfluthrin (ISO); reaction mass of rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate and rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate;
                              
                           
                                 —
                              
                              
                                 Opinion of 4 May 2020 concerning acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning tellurium;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning tellurium dioxide;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning 2,2-dimethylpropan-1-ol, tribromo derivative; 3-bromo-2,2-bis(bromomethyl)propan-1-ol;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning piperonyl butoxide (ISO); 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning benzophenone;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acrylate; isobornyl acrylate;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning daminozide (ISO); 4-(2,2-dimethylhydrazino)-4-oxobutanoic acid; N-dimethylaminosuccinamic acid;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning clofentezine (ISO); 3,6-bis(o-chlorophenyl)-1,2,4,5-tetrazine;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning fluopicolide (ISO); 2,6-dichloro-N-[3-chloro-5-(trifluoromethyl)-2-pyridylmethyl]benzamide;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning trichlorosilane;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning 2-ethylhexanoic acid and its salts;
                              
                           
                                 —
                              
                              
                                 Opinion of 11 June 2020 concerning a reassessment at the request of the European Commission of the developmental toxicity of N-carboxymethyliminobis (ethylenenitrilo)tetra(acetic acid) (DTPA) and its pentasodium and pentapotassium salts
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning dibutyltin bis(2-ethylhexanoate);
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning dibutyltin di(acetate);
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning barium diboron tetraoxide;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning quinoclamine (ISO); 2-amino-3-chloro-1,4-naphthoquinone;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 4,4'-oxydi(benzenesulphonohydrazide);
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 toluene-4-sulphonohydrazide;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 1,3-bis(1-isocyanato-1-methylethyl)benzene; [m-TMXDI];
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning Bis(isocyanatomethyl)benzene; [m-XDI];
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 2,4,6-triisopropyl-m-phenylene diisocyanate;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning N-(2-nitrophenyl)phosphoric triamide;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning cumene;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate;trimethylolpropane triacrylate;
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 1,5-naphthylene diisocyanate [containing < 0,1 % (w/w) of particles with an aerodynamic diameter of below 50 μm];
                              
                           
                                 —
                              
                              
                                 Opinion of 17 September 2020 concerning 1,5-naphthylene diisocyanate [containing ≥ 0,1 % (w/w) of particles with an aerodynamic diameter of below 50 μm];
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning ammonium bromide;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning 2,4,6-tri-tert-butylphenol;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning pyridalyl (ISO); 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning pyridine-2-thiol 1-oxide, sodium salt; pyrithione sodium; sodium pyrithione;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide; isoflucypram;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning 2-(2-methoxyethoxy)ethanol; diethylene glycol monomethyl ether;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning 4,4'-isopropylidenediphenol; bisphenol A;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning pendimethalin (ISO); N-(1-ethylpropyl)-2,6-dinitro-3,4-xylidene;
                              
                           
                                 —
                              
                              
                                 Opinion of 8 October 2020 concerning dimoxystrobin (ISO); (2E)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide; (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o-tolyl]acetamide;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning 4,4'-sulphonyldiphenol; bisphenol S;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 2-[N-ethyl-4-[(5-nitrothiazol-2-yl)azo]-m-toluidino]ethyl acetate; C.I. Disperse Blue 124;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning perfluoroheptanoic acid; tridecafluoroheptanoic acid;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning 6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning 6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning 6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning 1,3,5-triazine-2,4,6-triamine; Melamine;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide [≥ 78 % syn isomers ≤ 15 % anti isomers relative content]; isopyrazam;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning Margosa, ext. [from the kernels of Azadirachta indica extracted with water and further processed with organic solvents];
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning divanadium pentaoxide; vanadium pentoxide;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning bentazone (ISO); 3-isopropyl-2,1,3-benzothiadiazine-4-one-2,2-dioxide;
                              
                           
                                 —
                              
                              
                                 Opinion of 10 December 2020 concerning a reassessment at the request of the European Commission of the new information on acute inhalation toxicity of 2-butoxyethanol; ethylene glycol monobutyl ether (EGBE)
                              
                           
               
                     (3)
                  
                  
                     Additional information was received contesting the scientific assessment set out in the RAC opinions of 11 June 2020 concerning 2-ethylhexanoic acid and its salts; of 11 June 2020 concerning a reassessment at the request of the European Commission of the developmental toxicity of N-carboxymethyliminobis (ethylenenitrilo)tetra(acetic acid) (DTPA) and its pentasodium and pentapotassium salts; of 8 October 2020 concerning ammonium bromide; of 10 December 2020 concerning divanadium pentaoxide; of 10 December 2020 concerning a reassessment at the request of the European Commission of the new information on acute inhalation toxicity of 2-butoxyethanol; ethylene glycol monobutyl ether (EGBE); and of 10 December 2020 concerning melamine.
                  
               
                     (4)
                  
                  
                     This additional information was assessed by the Commission and was not found sufficient to cast doubts on the scientific analysis contained in the RAC opinions. It is therefore appropriate to introduce, update or delete the harmonised classification and labelling of the substances concerned on the basis of the assessment made in those opinions.
                  
               
                     (5)
                  
                  
                     Additional information pertaining to the acute inhalation toxicity of silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica; pyrogenic, synthetic amorphous, nano, surface treated silicon dioxide was received after the RAC opinion was forwarded to the Commission. The classification of silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica; pyrogenic, synthetic amorphous, nano, surface treated silicon dioxide as acute toxic by inhalation Cat. 2, recommended in the RAC opinion of 5 December 2019, should not be included in Annex VI to Regulation (EC) No 1272/2008, as the new scientific information was assessed by the Commission and was found to require further assessment by RAC. However, the classification of this substance as STOT RE 2, recommended in the RAC opinion of 5 December 2019, should be included in Annex VI to Regulation (EC) No 1272/2008, since no new information has been received that would require further assessment for that classification.
                  
               
                     (6)
                  
                  
                     Regulation (EC) No 1272/2008 should therefore be amended accordingly.
                  
               
                     (7)
                  
                  
                     Compliance with the new or updated harmonised classifications should not be required immediately as a certain period of time is necessary to allow suppliers to adapt the labelling and packaging of substances and mixtures to the new or updated classifications and to sell existing stocks subject to the pre-existing regulatory requirements. That period of time is also necessary to allow suppliers sufficient time to take the actions required to ensure continuing compliance with other legal requirements following the changes made under this Regulation. Suppliers should, however, have the possibility to apply the new or updated harmonised classifications, and to adapt the labelling and packaging accordingly, on a voluntary basis before the date of application of this Regulation, to ensure a high level of protection of human health and of the environment and to provide sufficient flexibility to suppliers,
                  
               HAS ADOPTED THIS REGULATION:
         
            Article 1
            Amendments to Regulation (EC) No 1272/2008
            Annex VI to Regulation (EC) No 1272/2008 is amended as set out in the Annex to this Regulation.
         
         
            Article 2
            Entry into force and application
            This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.
            It shall apply from 23 November 2023.
            By way of derogation from the second paragraph of this Article, substances and mixtures may be classified, labelled and packaged in accordance with this Regulation from its date of entry into force.
         
         
            This Regulation shall be binding in its entirety and directly applicable in all Member States.
            Done at Brussels, 16 February 2022.
            
               
                  For the Commission
               
               
                  The President
               
               Ursula VON DER LEYEN
            
         
         
            (1)  OJ L 353, 31.12.2008, p. 1.
         
            (2)  The opinions are accessible via the following website: https://echa.europa.eu/registry-of-clh-intentions-until-outcome/-/dislist/name/-/ecNumber/-/casNumber/-/dte_receiptFrom/-/dte_receiptTo/-/prc_public_status/Opinion+Adopted/dte_withdrawnFrom/-/dte_withdrawnTo/-/sbm_expected_submissionFrom/-/sbm_expected_submissionTo/-/dte_finalise_deadlineFrom/-/dte_finalise_deadlineTo/-/haz_addional_hazard/-/lec_submitter/-/dte_assessmentFrom/-/dte_assessmentTo/-/prc_regulatory_programme/-/. – The opinions of 11 June 2020 and of 10 December 2020 concerning a reassessment at the request of the European Commission are accessible via the following website: https://echa.europa.eu/about-us/who-we-are/committee-for-risk-assessment/opinions-of-the-rac-adopted-under-specific-echa-s-executive-director-requests
      
      
         
            ANNEX
            Annex VI to Regulation (EC) No 1272/2008 is amended as follows:
            
                        (1)
                     
                     
                        in Part 3, Table 3 is amended as follows:
                        
                                    (a)
                                 
                                 
                                    the following entries are inserted:
                                    
                                                Index No
                                             
                                             
                                                Chemical Name
                                             
                                             
                                                EC No
                                             
                                             
                                                CAS No
                                             
                                             
                                                Classification
                                             
                                             
                                                Labelling
                                             
                                             
                                                Specific Conc. Limits, M- factors and ATE
                                             
                                             
                                                Notes
                                             
                                          
                                                Hazard Class and Category Code(s)
                                             
                                             
                                                Hazard statement Code(s)
                                             
                                             
                                                Pictogram, Signal Word Code(s)
                                             
                                             
                                                Hazard statement Code(s)
                                             
                                             
                                                Suppl. Hazard statement Code(s)
                                             
                                          
                                                ‘014-052-00-7
                                             
                                             
                                                silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica; pyrogenic, synthetic amorphous, nano, surface treated silicon dioxide
                                             
                                             
                                                272-697-1
                                             
                                             
                                                68909-20-6
                                             
                                             
                                                STOT RE 2
                                             
                                             
                                                H373 (lungs) (inhalation)
                                             
                                             
                                                GHS08
                                                Wng
                                             
                                             
                                                H373 (lungs) (inhalation)
                                             
                                             
                                                EUH066’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘035-005-00-7
                                             
                                             
                                                ammonium bromide
                                             
                                             
                                                235-183-8
                                             
                                             
                                                12124-97-9
                                             
                                             
                                                Repr. 1B
                                                Lact.
                                                STOT SE 3
                                                STOT RE 1
                                                Eye Irrit. 2
                                             
                                             
                                                H360FD
                                                H362
                                                H336
                                                H372 (nervous system)
                                                H319
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360FD
                                                H362
                                                H336
                                                H372 (nervous system)
                                                H319’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘050-032-00-4
                                             
                                             
                                                dibutyltin bis(2-ethylhexanoate)
                                             
                                             
                                                220-481-2
                                             
                                             
                                                2781-10-4
                                             
                                             
                                                Muta. 2
                                                Repr. 1B
                                                STOT RE 1
                                             
                                             
                                                H341
                                                H360FD
                                                H372 (immune system)
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H341
                                                H360FD
                                                H372 (immune system)’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘050-033-00-X
                                             
                                             
                                                dibutyltin di(acetate)
                                             
                                             
                                                213-928-8
                                             
                                             
                                                1067-33-0
                                             
                                             
                                                Muta 2
                                                Repr. 1B
                                                STOT RE 1
                                             
                                             
                                                H341
                                                H360FD
                                                H372 (immune system)
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H341
                                                H360FD
                                                H372 (immune system)’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘052-001-00-0
                                             
                                             
                                                tellurium
                                             
                                             
                                                236-813-4
                                             
                                             
                                                13494-80-9
                                             
                                             
                                                Repr. 1B
                                                Lact.
                                             
                                             
                                                H360Df
                                                H362
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360Df
                                                H362’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘052-002-00-6
                                             
                                             
                                                tellurium dioxide
                                             
                                             
                                                231-193-1
                                             
                                             
                                                7446-07-3
                                             
                                             
                                                Repr. 1B
                                                Lact.
                                             
                                             
                                                H360Df
                                                H362
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360Df
                                                H362’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘056-005-00-3
                                             
                                             
                                                barium diboron tetraoxide
                                             
                                             
                                                237-222-4
                                             
                                             
                                                13701-59-2
                                             
                                             
                                                Repr. 1B
                                                Acute Tox. 4
                                                Acute Tox. 3
                                             
                                             
                                                H360FD
                                                H332
                                                H301
                                             
                                             
                                                GHS08
                                                GHS06
                                                Dgr
                                             
                                             
                                                H360FD
                                                H332
                                                H301
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 1,5 mg/L (dusts or mists)
                                                oral:
                                                ATE = 100 mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘601-097-00-8
                                             
                                             
                                                Propylbenzene
                                             
                                             
                                                203-132-9
                                             
                                             
                                                103-65-1
                                             
                                             
                                                Flam. Liq. 3
                                                Asp. Tox. 1
                                                STOT SE 3
                                                Aquatic Chronic 2
                                             
                                             
                                                H226
                                                H304
                                                H335
                                                H411
                                             
                                             
                                                GHS02
                                                GHS08
                                                GHS07
                                                GHS09
                                                Dgr
                                             
                                             
                                                H226
                                                H304
                                                H335
                                                H411’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘603-243-00-6
                                             
                                             
                                                2,2-dimethylpropan-1-ol, tribromo derivative; 3-bromo-2,2-bis(bromomethyl)propan-1-ol
                                             
                                             
                                                253-057-0
                                             
                                             
                                                36483-57-5; 1522-92-5
                                             
                                             
                                                Carc. 1B
                                                Muta. 2
                                             
                                             
                                                H350
                                                H341
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H350
                                                H341’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘604-096-00-0
                                             
                                             
                                                piperonyl butoxide (ISO); 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
                                             
                                             
                                                200-076-7
                                             
                                             
                                                51-03-6
                                             
                                             
                                                STOT SE 3
                                                Eye Irrit. 2
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H335
                                                H319
                                                H400
                                                H410
                                             
                                             
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H335
                                                H319
                                                H410
                                             
                                             
                                                EUH066
                                             
                                             
                                                M = 1
                                                M = 1’
                                             
                                             
                                                 
                                             
                                          
                                                ‘604-097-00-6
                                             
                                             
                                                2,4,6-tri-tert-butylphenol
                                             
                                             
                                                211-989-5
                                             
                                             
                                                732-26-3
                                             
                                             
                                                Repr. 1B
                                                Acute Tox. 4
                                                STOT RE 2
                                                Skin Sens. 1B
                                             
                                             
                                                H360D
                                                H302
                                                H373 (liver)
                                                H317
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360D
                                                H302
                                                H373 (liver)
                                                H317
                                             
                                             
                                                 
                                             
                                             
                                                oral:
                                                ATE = 500 mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘604-098-00-1
                                             
                                             
                                                4,4'-sulphonyldiphenol; bisphenol S
                                             
                                             
                                                201-250-5
                                             
                                             
                                                80-09-1
                                             
                                             
                                                Repr. 1B
                                             
                                             
                                                H360FD
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360FD’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘606-153-00-5
                                             
                                             
                                                benzophenone
                                             
                                             
                                                204-337-6
                                             
                                             
                                                119-61-9
                                             
                                             
                                                Carc. 1B
                                             
                                             
                                                H350
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H350’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘606-154-00-0
                                             
                                             
                                                quinoclamine (ISO); 2-amino-3-chloro-1,4-naphthoquinone
                                             
                                             
                                                220-529-2
                                             
                                             
                                                2797-51-5
                                             
                                             
                                                Carc. 2
                                                Repr. 2
                                                Acute Tox. 4
                                                STOT RE 2
                                                Eye Irrit. 2
                                                Skin Sens. 1A
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H351
                                                H361d
                                                H302
                                                H373 (blood system, kidneys)
                                                H319
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H351
                                                H361d
                                                H302
                                                H373 (blood system, kidneys)
                                                H319
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                oral:
                                                ATE = 500 mg/kg bw
                                                M = 10
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-756-00-6
                                             
                                             
                                                exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acrylate; isobornyl acrylate
                                             
                                             
                                                227-561-6
                                             
                                             
                                                5888-33-5
                                             
                                             
                                                Skin Sens. 1A
                                             
                                             
                                                H317
                                             
                                             
                                                GHS07
                                                Wng
                                             
                                             
                                                H317’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-757-00-1
                                             
                                             
                                                daminozide (ISO); 4-(2,2-dimethylhydrazino)-4-oxobutanoic acid; N-dimethylaminosuccinamic acid
                                             
                                             
                                                216-485-9
                                             
                                             
                                                1596-84-5
                                             
                                             
                                                Carc. 2
                                             
                                             
                                                H351
                                             
                                             
                                                GHS08
                                                Wng
                                             
                                             
                                                H351’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-758-00-7
                                             
                                             
                                                4,4'-oxydi(benzenesulphonohydrazide)
                                             
                                             
                                                201-286-1
                                             
                                             
                                                80-51-3
                                             
                                             
                                                Self-react. D
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H242
                                                H400
                                                H410
                                             
                                             
                                                GHS02
                                                GHS09
                                                Dgr
                                             
                                             
                                                H242
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 1
                                                M = 1’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-759-00-2
                                             
                                             
                                                toluene-4-sulphonohydrazide
                                             
                                             
                                                216-407-3
                                             
                                             
                                                1576-35-8
                                             
                                             
                                                Self-react. D
                                             
                                             
                                                H242
                                             
                                             
                                                GHS02
                                                Dgr
                                             
                                             
                                                H242’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-760-00-8
                                             
                                             
                                                2-[N-ethyl-4-[(5-nitrothiazol-2-yl)azo]-m-toluidino]ethyl acetate; C.I. Disperse Blue 124
                                             
                                             
                                                239-203-6
                                             
                                             
                                                15141-18-1
                                             
                                             
                                                Skin Sens. 1A
                                             
                                             
                                                H317
                                             
                                             
                                                GHS07
                                                Wng
                                             
                                             
                                                H317
                                             
                                             
                                                 
                                             
                                             
                                                Skin Sens. 1A; H317: C ≥ 0,001 %’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-761-00-3
                                             
                                             
                                                Perfluoroheptanoic acid; tridecafluoroheptanoic acid
                                             
                                             
                                                206-798-9
                                             
                                             
                                                375-85-9
                                             
                                             
                                                Repr. 1B
                                                STOT RE 1
                                             
                                             
                                                H360D
                                                H372 (liver)
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360D
                                                H372 (liver)’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-762-00-9
                                             
                                             
                                                methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate
                                             
                                             
                                                -
                                             
                                             
                                                283159-90-0
                                             
                                             
                                                Carc. 2
                                                Aquatic Chronic 2
                                             
                                             
                                                H351
                                                H411
                                             
                                             
                                                GHS08
                                                GHS09
                                                Wng
                                             
                                             
                                                H351
                                                H411’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-763-00-4
                                             
                                             
                                                6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts
                                             
                                             
                                                -
                                             
                                             
                                                -
                                             
                                             
                                                Repr. 1B
                                                Eye Irrit. 2
                                             
                                             
                                                H360FD
                                                H319
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360FD
                                                H319’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-764-00-X
                                             
                                             
                                                6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
                                             
                                             
                                                -
                                             
                                             
                                                2156592-54-8
                                             
                                             
                                                Repr. 1B
                                                Eye Irrit. 2
                                             
                                             
                                                H360FD
                                                H319
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360FD
                                                H319’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-765-00-5
                                             
                                             
                                                6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
                                             
                                             
                                                -
                                             
                                             
                                                -
                                             
                                             
                                                Repr. 1B
                                             
                                             
                                                H360FD
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360FD’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-341-00-0
                                             
                                             
                                                clofentezine (ISO); 3,6-bis(o-chlorophenyl)-1,2,4,5-tetrazine
                                             
                                             
                                                277-728-2
                                             
                                             
                                                74115-24-5
                                             
                                             
                                                Aquatic Chronic 1
                                             
                                             
                                                H410
                                             
                                             
                                                GHS09
                                                Wng
                                             
                                             
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 1’
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-342-00-6
                                             
                                             
                                                theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
                                             
                                             
                                                200-385-7
                                             
                                             
                                                58-55-9
                                             
                                             
                                                Repr. 1B
                                             
                                             
                                                H360D
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360D’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-343-00-1
                                             
                                             
                                                pyridalyl (ISO); 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether
                                             
                                             
                                                -
                                             
                                             
                                                179101-81-6
                                             
                                             
                                                Skin Sens. 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 1 000 
                                                M = 100’
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-344-00-7
                                             
                                             
                                                Pyridine-2-thiol 1-oxide, sodium salt; pyrithione sodium; sodium pyrithione
                                             
                                             
                                                223-296-5;
                                                240-062-8
                                             
                                             
                                                3811-73-2;
                                                15922-78-8
                                             
                                             
                                                Acute Tox. 3
                                                Acute Tox. 3
                                                Acute Tox. 4
                                                STOT RE 1
                                                Skin Irrit. 2
                                                Eye Irrit. 2
                                                Skin Sens. 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 2
                                             
                                             
                                                H331
                                                H311
                                                H302
                                                H372 (nervous system)
                                                H315
                                                H319
                                                H317
                                                H400
                                                H411
                                             
                                             
                                                GHS06
                                                GHS08
                                                GHS09
                                                Dgr
                                             
                                             
                                                H331
                                                H311
                                                H302
                                                H372 (nervous system)
                                                H315
                                                H319
                                                H317
                                                H410
                                             
                                             
                                                EUH070
                                             
                                             
                                                inhalation:
                                                ATE = 0,5 mg/L (dusts or mists)
                                                dermal:
                                                ATE = 790 mg/kg bw
                                                oral:
                                                ATE = 500 mg/kg bw
                                                M = 100’
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-345-00-2
                                             
                                             
                                                1,3,5-triazine-2,4,6-triamine;
                                                melamine
                                             
                                             
                                                203-615-4
                                             
                                             
                                                108-78-1
                                             
                                             
                                                Carc. 2
                                                STOT RE 2
                                             
                                             
                                                H351
                                                H373 (urinary tract)
                                             
                                             
                                                GHS08
                                                Wng
                                             
                                             
                                                H351
                                                H373 (urinary tract)’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘615-046-00-2
                                             
                                             
                                                1,3-bis(1-isocyanato-1-methylethyl)benzene; [m-TMXDI]
                                             
                                             
                                                220-474-4
                                             
                                             
                                                2778-42-9
                                             
                                             
                                                Resp. Sens. 1
                                                Skin Sens. 1A
                                             
                                             
                                                H334
                                                H317
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H334
                                                H317’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘615-047-00-8
                                             
                                             
                                                1,3-bis(isocyanatomethyl)benzene; [m-XDI]
                                             
                                             
                                                222-852-4
                                             
                                             
                                                3634-83-1
                                             
                                             
                                                Resp. Sens. 1
                                                Skin Sens. 1A
                                             
                                             
                                                H334
                                                H317
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H334
                                                H317
                                             
                                             
                                                 
                                             
                                             
                                                Skin Sens. 1A; H317: C ≥ 0,001 %’
                                             
                                             
                                                 
                                             
                                          
                                                ‘615-048-00-3
                                             
                                             
                                                2,4,6-triisopropyl-m-phenylene diisocyanate
                                             
                                             
                                                218-485-4
                                             
                                             
                                                2162-73-4
                                             
                                             
                                                Resp. Sens. 1
                                                Skin Sens. 1
                                             
                                             
                                                H334
                                                H317
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H334
                                                H317’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘615-049-00-9
                                             
                                             
                                                1,5-naphthylene diisocyanate
                                                [containing < 0,1 % (w/w) of particles with an aerodynamic diameter of below 50 μm]
                                             
                                             
                                                221-641-4
                                             
                                             
                                                3173-72-6
                                             
                                             
                                                STOT SE 3
                                                Skin Irrit. 2
                                                Eye Irrit. 2
                                                Resp. Sens. 1
                                                Skin Sens. 1A
                                                Aquatic Chronic 3
                                             
                                             
                                                H335
                                                H315
                                                H319
                                                H334
                                                H317
                                                H412
                                             
                                             
                                                GHS07
                                                GHS08
                                                Dgr
                                             
                                             
                                                H335
                                                H315
                                                H319
                                                H334
                                                H317
                                                H412’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘615-050-00-4
                                             
                                             
                                                1,5-naphthylene diisocyanate
                                                [containing ≥ 0,1 % (w/w) of particles with an aerodynamic diameter of below 50 μm]
                                             
                                             
                                                221-641-4
                                             
                                             
                                                3173-72-6
                                             
                                             
                                                Acute Tox. 2
                                                STOT SE 3
                                                Skin Irrit. 2
                                                Eye Irrit. 2
                                                Resp. Sens. 1
                                                Skin Sens. 1A
                                                Aquatic Chronic 3
                                             
                                             
                                                H330
                                                H335
                                                H315
                                                H319
                                                H334
                                                H317
                                                H412
                                             
                                             
                                                GHS06
                                                GHS08
                                                Dgr
                                             
                                             
                                                H330
                                                H335
                                                H315
                                                H319
                                                H334
                                                H317
                                                H412
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 0,27 mg/L (dusts or mists)’
                                             
                                             
                                                 
                                             
                                          
                                                ‘616-237-00-3
                                             
                                             
                                                fluopicolide (ISO); 2,6-dichloro-N-[3-chloro-5-(trifluoromethyl)-2-pyridylmethyl]benzamide
                                             
                                             
                                                -
                                             
                                             
                                                239110-15-7
                                             
                                             
                                                Repr. 2
                                             
                                             
                                                H361d
                                             
                                             
                                                GHS08
                                                Wng
                                             
                                             
                                                H361d’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘616-238-00-9
                                             
                                             
                                                
                                                   N-(2-nitrophenyl)phosphoric triamide
                                             
                                             
                                                477-690-9
                                             
                                             
                                                874819-71-3
                                             
                                             
                                                Repr. 1B
                                                STOT RE 2
                                             
                                             
                                                H360Fd
                                                H373 (kidneys)
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360Fd
                                                H373 (kidneys)’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘616-239-00-4
                                             
                                             
                                                
                                                   N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide; isoflucypram
                                             
                                             
                                                -
                                             
                                             
                                                1255734-28-1
                                             
                                             
                                                Repr. 2
                                                Acute Tox. 4
                                                Skin Sens. 1B
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H361f
                                                H332
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H361f
                                                H332
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 2,2 mg/L (dusts or mists)
                                                M = 10
                                                M = 1’
                                             
                                             
                                                 
                                             
                                          
                                                ‘616-240-00-X
                                             
                                             
                                                Reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide [≥ 78 % syn isomers ≤ 15 % anti isomers relative content]; isopyrazam
                                             
                                             
                                                -
                                             
                                             
                                                881685-58-1
                                             
                                             
                                                Carc. 2
                                                Repr. 1B
                                                Skin Sens. 1B
                                                Aquatic Acute 1 Aquatic Chronic 1
                                             
                                             
                                                H351
                                                H360D
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Dgr
                                             
                                             
                                                H351
                                                H360D
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                Repr. 1B; H360D:
                                                C ≥ 3 %
                                                M = 10
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                                                ‘650-058-00-1
                                             
                                             
                                                Margosa, ext. [from the kernels of Azadirachta indica extracted with water and further processed with organic solvents]
                                             
                                             
                                                283-644-7
                                             
                                             
                                                84696-25-3
                                             
                                             
                                                Repr. 2
                                                Skin Sens. 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H361d
                                                H317
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H361d
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                              
                                    (b)
                                 
                                 
                                    the entries corresponding to index numbers 014-001-00-9; 023-001-00-8; 601-024-00-X; 603-014-00-0; 603-107-00-6; 604-030-00-0; 607-111-00-9; 607-230-00-6; 607-253-00-1; 607-254-00-7; 607-734-00-6; 607-735-00-1; 607-736-00-7; 608-032-00-2; 609-042-00-X; 613-012-00-1; 616-164-00-7 are replaced by the following entries respectively:
                                    
                                                Index No
                                             
                                             
                                                Chemical Name
                                             
                                             
                                                EC No
                                             
                                             
                                                CAS No
                                             
                                             
                                                Classification
                                             
                                             
                                                Labelling
                                             
                                             
                                                Specific Conc. Limits, M- factors and ATE
                                             
                                             
                                                Notes
                                             
                                          
                                                Hazard Class and Category Code(s)
                                             
                                             
                                                Hazard statement Code(s)
                                             
                                             
                                                Pictogram, Signal Word Code(s)
                                             
                                             
                                                Hazard statement Code(s)
                                             
                                             
                                                Suppl. Hazard statement Code(s)
                                             
                                          
                                                ‘014-001-00-9
                                             
                                             
                                                trichlorosilane
                                             
                                             
                                                233-042-5
                                             
                                             
                                                10025-78-2
                                             
                                             
                                                Flam. Liq. 1
                                                Water-react. 1
                                                Acute Tox. 3
                                                Acute Tox. 4
                                                Skin Corr. 1A
                                                Eye Dam. 1
                                             
                                             
                                                H224
                                                H260
                                                H331
                                                H302
                                                H314
                                                H318
                                             
                                             
                                                GHS02
                                                GHS06
                                                GHS05
                                                Dgr
                                             
                                             
                                                H224
                                                H260
                                                H331
                                                H302
                                                H314
                                             
                                             
                                                EUH014
                                                EUH029
                                                EUH071
                                             
                                             
                                                inhalation:
                                                ATE = 7,6 mg/L (vapour)
                                                oral:
                                                ATE = 1 000  mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘023-001-00-8
                                             
                                             
                                                divanadium pentaoxide; vanadium pentoxide
                                             
                                             
                                                215-239-8
                                             
                                             
                                                1314-62-1
                                             
                                             
                                                Muta. 2
                                                Carc. 1B
                                                Repr. 2
                                                Lact.
                                                Acute Tox. 3
                                                Acute Tox. 2
                                                STOT SE 3
                                                STOT RE 1
                                                Aquatic Chronic 2
                                             
                                             
                                                H341
                                                H350
                                                H361fd
                                                H362
                                                H301
                                                H330
                                                H335
                                                H372 (respiratory tract, inhalation)
                                                H411
                                             
                                             
                                                GHS06
                                                GHS08
                                                GHS09
                                                Dgr
                                             
                                             
                                                H341
                                                H350
                                                H361fd
                                                H362
                                                H301
                                                H330
                                                H335
                                                H372 (respiratory tract, inhalation)
                                                H411
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 0,05 mg/L (dusts or mists)
                                                oral:
                                                ATE = 220 mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘601-024-00-X
                                             
                                             
                                                Cumene
                                             
                                             
                                                202-704-5
                                             
                                             
                                                98-82-8
                                             
                                             
                                                Flam. Liq. 3
                                                Carc. 1B
                                                Asp. Tox. 1
                                                STOT SE 3
                                                Aquatic Chronic 2
                                             
                                             
                                                H226
                                                H350
                                                H304
                                                H335
                                                H411
                                             
                                             
                                                GHS02
                                                GHS08
                                                GHS07
                                                GHS09
                                                Dgr
                                             
                                             
                                                H226
                                                H350
                                                H304
                                                H335
                                                H411’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘603-014-00-0
                                             
                                             
                                                2-butoxyethanol; ethylene glycol monobutyl ether
                                             
                                             
                                                203-905-0
                                             
                                             
                                                111-76-2
                                             
                                             
                                                Acute Tox. 3
                                                Acute Tox. 4
                                                Skin Irrit. 2
                                                Eye Irrit. 2
                                             
                                             
                                                H331
                                                H302
                                                H315
                                                H319
                                             
                                             
                                                GHS06
                                                Dgr
                                             
                                             
                                                H331
                                                H302
                                                H315
                                                H319
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 3 mg/L (Vapours)
                                                oral:
                                                ATE = 1 200  mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘603-107-00-6
                                             
                                             
                                                2-(2-methoxyethoxy)ethanol; diethylene glycol monomethyl ether
                                             
                                             
                                                203-906-6
                                             
                                             
                                                111-77-3
                                             
                                             
                                                Repr. 1B
                                             
                                             
                                                H360D
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360D
                                             
                                             
                                                 
                                             
                                             
                                                Repr. 1B; H360D: C ≥ 3 %’
                                             
                                             
                                                 
                                             
                                          
                                                ‘604-030-00-0
                                             
                                             
                                                4,4'-isopropylidenediphenol; bisphenol A
                                             
                                             
                                                201-245-8
                                             
                                             
                                                80-05-7
                                             
                                             
                                                Repr. 1B
                                                STOT SE 3
                                                Eye Dam. 1
                                                Skin Sens. 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H360F
                                                H335
                                                H318
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS05
                                                GHS09
                                                Dgr
                                             
                                             
                                                H360F
                                                H335
                                                H318
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 1
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-111-00-9
                                             
                                             
                                                2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate;
                                                trimethylolpropane triacrylate
                                             
                                             
                                                239-701-3
                                             
                                             
                                                15625-89-5
                                             
                                             
                                                Carc. 2
                                                Skin Irrit. 2
                                                Eye Irrit. 2
                                                Skin Sens. 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H351
                                                H315
                                                H319
                                                H317
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H351
                                                H315
                                                H319
                                                H317
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 1
                                                M = 1
                                             
                                             
                                                D’
                                             
                                          
                                                ‘607-230-00-6
                                             
                                             
                                                2-ethylhexanoic acid and its salts, with the exception of those specified elsewhere in this Annex
                                             
                                             
                                                -
                                             
                                             
                                                -
                                             
                                             
                                                Repr. 1B
                                             
                                             
                                                H360D
                                             
                                             
                                                GHS08
                                                Dgr
                                             
                                             
                                                H360D’
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-253-00-1
                                             
                                             
                                                cyfluthrin (ISO); α-cyano-4-fluoro-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
                                             
                                             
                                                269-855-7
                                             
                                             
                                                68359-37-5
                                             
                                             
                                                Lact.
                                                Acute Tox. 2
                                                Acute Tox. 2
                                                STOT SE 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H362
                                                H330
                                                H300
                                                H370 (nervous system)
                                                H400
                                                H410
                                             
                                             
                                                GHS06
                                                GHS08
                                                GHS09
                                                Dgr
                                             
                                             
                                                H362
                                                H330
                                                H300
                                                H370 (nervous system)
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 0,14 mg/L (dusts or mists)
                                                oral:
                                                ATE = 14 mg/kg bw
                                                M = 1 000 000 
                                                M = 1 000 000 ’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-254-00-7
                                             
                                             
                                                beta-cyfluthrin (ISO); reaction mass of rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate and rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
                                             
                                             
                                                -
                                             
                                             
                                                1820573-27-0
                                             
                                             
                                                Lact.
                                                Acute Tox. 2
                                                Acute Tox. 2
                                                STOT SE 1
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H362
                                                H330
                                                H300
                                                H370 (nervous system)
                                                H400
                                                H410
                                             
                                             
                                                GHS06
                                                GHS08
                                                GHS09
                                                Dgr
                                             
                                             
                                                H362
                                                H330
                                                H300
                                                H370 (nervous system)
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 0,081 mg/L (dusts or mists)
                                                oral:
                                                ATE = 11 mg/kg bw
                                                M = 1 000 000 
                                                M = 1 000 000 ’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-734-00-6
                                             
                                             
                                                pentapotassium 2,2',2",2"',2""-(ethane-1,2-diylnitrilo)pentaacetate
                                             
                                             
                                                404-290-3
                                             
                                             
                                                7216-95-7
                                             
                                             
                                                Repr. 1B
                                                Acute Tox. 4
                                                STOT RE 2
                                                Eye Irrit. 2
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                                H319
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                                H319
                                             
                                             
                                                 
                                             
                                             
                                                Repr. 1B; H360D: C ≥ 3 %
                                                inhalation:
                                                ATE = 1,5 mg/L (dusts or mists)’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-735-00-1
                                             
                                             
                                                
                                                   N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
                                             
                                             
                                                200-652-8
                                             
                                             
                                                67-43-6
                                             
                                             
                                                Repr. 1B
                                                Acute Tox. 4
                                                STOT RE 2
                                                Eye Irrit. 2
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                                H319
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                                H319
                                             
                                             
                                                 
                                             
                                             
                                                Repr. 1B; H360D: C ≥ 3 %
                                                inhalation:
                                                ATE = 1,5 mg/L (dusts or mists)’
                                             
                                             
                                                 
                                             
                                          
                                                ‘607-736-00-7
                                             
                                             
                                                pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate
                                             
                                             
                                                205-391-3
                                             
                                             
                                                140-01-2
                                             
                                             
                                                Repr. 1B
                                                Acute Tox. 4
                                                STOT RE 2
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                             
                                             
                                                GHS08
                                                GHS07
                                                Dgr
                                             
                                             
                                                H360D
                                                H332
                                                H373 (inhalation)
                                             
                                             
                                                 
                                             
                                             
                                                Repr. 1B; H360D: C ≥ 3 %
                                                inhalation:
                                                ATE = 1,5 mg/L (dusts or mists)’
                                             
                                             
                                                 
                                             
                                          
                                                ‘608-032-00-2
                                             
                                             
                                                acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
                                             
                                             
                                                -
                                             
                                             
                                                135410-20-7 160430-64-8
                                             
                                             
                                                Repr. 2
                                                Acute Tox. 3
                                                Aquatic Chronic 1
                                                Aquatic Acute 1
                                             
                                             
                                                H361d
                                                H301
                                                H410
                                                H400
                                             
                                             
                                                GHS08
                                                GHS06
                                                GHS09
                                                Dgr
                                             
                                             
                                                H361d
                                                H301
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                oral:
                                                ATE = 140 mg/kg bw
                                                M = 10
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                                                ‘609-042-00-X
                                             
                                             
                                                pendimethalin (ISO); N-(1-ethylpropyl)-2,6-dinitro-3,4-xylidene
                                             
                                             
                                                254-938-2
                                             
                                             
                                                40487-42-1
                                             
                                             
                                                Repr. 2
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H361d
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GSH09
                                                Wng
                                             
                                             
                                                H361d
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                M = 100
                                                M = 10’
                                             
                                             
                                                 
                                             
                                          
                                                ‘613-012-00-1
                                             
                                             
                                                bentazone (ISO); 3-isopropyl-2,1,3-benzothiadiazine-4-one-2,2-dioxide
                                             
                                             
                                                246-585-8
                                             
                                             
                                                25057-89-0
                                             
                                             
                                                Repr. 2
                                                Acute Tox. 4
                                                Eye Irrit. 2
                                                Skin Sens. 1
                                             
                                             
                                                H361d
                                                H302
                                                H319
                                                H317
                                             
                                             
                                                GHS08
                                                GHS07
                                                Wng
                                             
                                             
                                                H361d
                                                H302
                                                H319
                                                H317
                                             
                                             
                                                 
                                             
                                             
                                                oral: ATE = 1 600  mg/kg bw’
                                             
                                             
                                                 
                                             
                                          
                                                ‘616-164-00-7
                                             
                                             
                                                dimoxystrobin (ISO); (2E)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide; (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o-tolyl]acetamide
                                             
                                             
                                                 
                                             
                                             
                                                149961-52-4
                                             
                                             
                                                Carc. 2
                                                Repr. 2
                                                Acute Tox. 4
                                                Aquatic Acute 1
                                                Aquatic Chronic 1
                                             
                                             
                                                H351
                                                H361d
                                                H332
                                                H400
                                                H410
                                             
                                             
                                                GHS08
                                                GHS07
                                                GHS09
                                                Wng
                                             
                                             
                                                H351
                                                H361d
                                                H332
                                                H410
                                             
                                             
                                                 
                                             
                                             
                                                inhalation:
                                                ATE = 1,3 mg/L (dusts or mists)
                                                M = 100
                                                M = 100’
                                             
                                             
                                                 
                                             
                                          
                              
                                    (c)
                                 
                                 
                                    the entry corresponding to index number 615-007-00-X is deleted.