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All are features of Abetalipoproteinemia, EXCEPT: | Plasma levels of cholesterol and triglyceride are extremely low | Manifest in early childhood with diarrhea | Progressive pigmented retinopathy seen | Neurological manifestation as ataxia in first decade | 3 | [
"Abetalipoproteinemia"
] | Question: All are features of Abetalipoproteinemia, EXCEPT:
Choices:
A. Plasma levels of cholesterol and triglyceride are extremely low
B. Manifest in early childhood with diarrhea
C. Progressive pigmented retinopathy seen
D. Neurological manifestation as ataxia in first decade
Answer: |
Abetalipoproteinemia is due to deficiency of - | Lecithin Cholesterol Acyl Transferase | ATP Binding Cassette Transporter-1 | Mitochondrial Triglyceride Transfer Protein | ApoCII | 2 | [
"Abetalipoproteinemia"
] | Question: Abetalipoproteinemia is due to deficiency of -
Choices:
A. Lecithin Cholesterol Acyl Transferase
B. ATP Binding Cassette Transporter-1
C. Mitochondrial Triglyceride Transfer Protein
D. ApoCII
Answer: |
Small intestinal biopsy is diagnostic in :a) Whipple's diseaseb) Abetalipoproteinemiac) Celiac diseased) Agammaglobulinemia | acd | bcd | abd | ab | 2 | [
"Abetalipoproteinemia",
"Agammaglobulinemia"
] | Question: Small intestinal biopsy is diagnostic in :a) Whipple's diseaseb) Abetalipoproteinemiac) Celiac diseased) Agammaglobulinemia
Choices:
A. acd
B. bcd
C. abd
D. ab
Answer: |
Intermittent dysphagia is caused by -a) Strictureb) Reflux esophagitisc) Achalasia cardiad) Pharyngeal diverticululame) Diffuse esophageal spasm | ab | bc | de | bd | 2 | [
"Achalasia"
] | Question: Intermittent dysphagia is caused by -a) Strictureb) Reflux esophagitisc) Achalasia cardiad) Pharyngeal diverticululame) Diffuse esophageal spasm
Choices:
A. ab
B. bc
C. de
D. bd
Answer: |
Following are radiological evidence of Achalasia cardia except not related -radiology | Smooth narrowing of esophagus | Dilated touous esophagus | Absence of air in the fundus | Exaggerated peristalsis | 3 | [
"Achalasia"
] | Question: Following are radiological evidence of Achalasia cardia except not related -radiology
Choices:
A. Smooth narrowing of esophagus
B. Dilated touous esophagus
C. Absence of air in the fundus
D. Exaggerated peristalsis
Answer: |
Which drug is used for Achalasia cardia- | Nifedipine | Propranolal | Atenolol | Bethnecol | 0 | [
"Achalasia"
] | Question: Which drug is used for Achalasia cardia-
Choices:
A. Nifedipine
B. Propranolal
C. Atenolol
D. Bethnecol
Answer: |
Achalasia is associated with increased risk of ...... malignancy: | Squamous cell carcinoma esophagus | Adenocarcinoma esophagus | Bronchogenic carcinoma | Bronchial adenoma | 0 | [
"Achalasia"
] | Question: Achalasia is associated with increased risk of ...... malignancy:
Choices:
A. Squamous cell carcinoma esophagus
B. Adenocarcinoma esophagus
C. Bronchogenic carcinoma
D. Bronchial adenoma
Answer: |
Which investigation is not required in diagnosis of Achalasia? | Esophageal manometry | Barium swallow | Anti-neuronal antibodies | Enterocylsis | 3 | [
"Achalasia"
] | Question: Which investigation is not required in diagnosis of Achalasia?
Choices:
A. Esophageal manometry
B. Barium swallow
C. Anti-neuronal antibodies
D. Enterocylsis
Answer: |
About Achalasia Cardia: 1. Dysphagia is a presenting symptom 2. The cause is the absence of Auerbach's plexus 3. Esophagectomy is the treatment 4. Motility improving agents are used in treatment 5. Barium swallow shows irregular filling defects in lower esophagus | 1,2,3 False & 4,5 True | 1,2,4 True & 3,5 False | 2,3,4 True &1,5 False | 1,3,5 True & 2,4 False | 1 | [
"Achalasia"
] | Question: About Achalasia Cardia: 1. Dysphagia is a presenting symptom 2. The cause is the absence of Auerbach's plexus 3. Esophagectomy is the treatment 4. Motility improving agents are used in treatment 5. Barium swallow shows irregular filling defects in lower esophagus
Choices:
A. 1,2,3 False & 4,5 True
B. 1,2,4 True & 3,5 False
C. 2,3,4 True &1,5 False
D. 1,3,5 True & 2,4 False
Answer: |
Feature of Achalasia cardia (cardiospasm) include all of the following except- | Increasing dificulty in swallowing more for liquids than for soilds | Regurgitant vomiting | Dilated & turtuous esophagus | Filling defect on barium study | 3 | [
"Achalasia"
] | Question: Feature of Achalasia cardia (cardiospasm) include all of the following except-
Choices:
A. Increasing dificulty in swallowing more for liquids than for soilds
B. Regurgitant vomiting
C. Dilated & turtuous esophagus
D. Filling defect on barium study
Answer: |
Barret's esophagus can lead to -a) Strictureb) Reflux esophagitisc) Peptic ulcerd) Achalasia | ac | bc | ad | b | 0 | [
"Achalasia"
] | Question: Barret's esophagus can lead to -a) Strictureb) Reflux esophagitisc) Peptic ulcerd) Achalasia
Choices:
A. ac
B. bc
C. ad
D. b
Answer: |
Odynophagia occurs ina) Achalasiab) Herpes esophagitisc) Monilial esophagitisd) Barret's oesophagus | a | c | ac | bc | 3 | [
"Achalasia"
] | Question: Odynophagia occurs ina) Achalasiab) Herpes esophagitisc) Monilial esophagitisd) Barret's oesophagus
Choices:
A. a
B. c
C. ac
D. bc
Answer: |
Achalasia cardia presents with all EXCEPT: | Increased lower esophalgus sphincter tone | Normal peristalsis | Dilatation proximally | Malignancy | 1 | [
"Achalasia"
] | Question: Achalasia cardia presents with all EXCEPT:
Choices:
A. Increased lower esophalgus sphincter tone
B. Normal peristalsis
C. Dilatation proximally
D. Malignancy
Answer: |
Intermittent dysphagia is caused by -a) Strictureb) Reflux esophagitisc) Achalasia cardiad) Pharyngeal diverticulme) Diffuse esophageal spasm | ab | bc | cd | de | 3 | [
"Achalasia"
] | Question: Intermittent dysphagia is caused by -a) Strictureb) Reflux esophagitisc) Achalasia cardiad) Pharyngeal diverticulme) Diffuse esophageal spasm
Choices:
A. ab
B. bc
C. cd
D. de
Answer: |
Radiologic feature suggestive of Achalasia cardia is? | Absence of gastric air bubble | Air fluid level in mediastinum | Sigmoid ecophagus | All of the above | 3 | [
"Achalasia"
] | Question: Radiologic feature suggestive of Achalasia cardia is?
Choices:
A. Absence of gastric air bubble
B. Air fluid level in mediastinum
C. Sigmoid ecophagus
D. All of the above
Answer: |
Achalasia cardia due to: | Degeneration of myenteric plexus due to toxin | Degeneration and absence of ganglion cells in auerbach' Plexus | Excess of Ganglion cells in auerbach Plexus | Degeneration of meissner's Plexus | 1 | [
"Achalasia"
] | Question: Achalasia cardia due to:
Choices:
A. Degeneration of myenteric plexus due to toxin
B. Degeneration and absence of ganglion cells in auerbach' Plexus
C. Excess of Ganglion cells in auerbach Plexus
D. Degeneration of meissner's Plexus
Answer: |
In which of the following condition does odynohagia occur? 1. Achalasia 2. Herpes esophagitis 3. Monilial esophagitis 4. Barrett's esophagus | 1 & 2 | 2 & 3 | 1,2 & 3 | 1,2,3 & 4 | 1 | [
"Achalasia"
] | Question: In which of the following condition does odynohagia occur? 1. Achalasia 2. Herpes esophagitis 3. Monilial esophagitis 4. Barrett's esophagus
Choices:
A. 1 & 2
B. 2 & 3
C. 1,2 & 3
D. 1,2,3 & 4
Answer: |
Following are radiological evidence of Achalasia cardia Except | Beak like appearance | Dilated touous esophagus | Presence of air-fluid level | Exaggerated peristalsis | 3 | [
"Achalasia"
] | Question: Following are radiological evidence of Achalasia cardia Except
Choices:
A. Beak like appearance
B. Dilated touous esophagus
C. Presence of air-fluid level
D. Exaggerated peristalsis
Answer: |
Which of the following disease causes Achalasia | Kala azar | Chaga's disease | KFD | Schistosomiasis | 1 | [
"Achalasia"
] | Question: Which of the following disease causes Achalasia
Choices:
A. Kala azar
B. Chaga's disease
C. KFD
D. Schistosomiasis
Answer: |
In which of the following conditions, uniform dilation of esophagus is seen -a) Sclerodermab) Achalasia cardiac) Dermatomyositisd) Trypanosoma cruzi infection | c | bd | ab | ac | 1 | [
"Achalasia",
"Dermatomyositis",
"Scleroderma"
] | Question: In which of the following conditions, uniform dilation of esophagus is seen -a) Sclerodermab) Achalasia cardiac) Dermatomyositisd) Trypanosoma cruzi infection
Choices:
A. c
B. bd
C. ab
D. ac
Answer: |
Radiologic feature suggestive of Achalasia cardia is- | Absence of gastric air bubble | Air fluid level in mediastinum | Sigmoid ecophagus | All of the above | 3 | [
"Achalasia"
] | Question: Radiologic feature suggestive of Achalasia cardia is-
Choices:
A. Absence of gastric air bubble
B. Air fluid level in mediastinum
C. Sigmoid ecophagus
D. All of the above
Answer: |
Intermittent dysphagia is caused by? 1. Stricture 2. Reflux esophagitis 3. Achalasia cardia 4. Pharyngeal diveiculum 5. Diffuse esophageal spasm | 1,2 & 3 | 2,3 & 4 | 4 & 5 | 3,4 & 5 | 2 | [
"Achalasia"
] | Question: Intermittent dysphagia is caused by? 1. Stricture 2. Reflux esophagitis 3. Achalasia cardia 4. Pharyngeal diveiculum 5. Diffuse esophageal spasm
Choices:
A. 1,2 & 3
B. 2,3 & 4
C. 4 & 5
D. 3,4 & 5
Answer: |
Gold standard Investigation for Achalasia cardia is : | Esophageal manometry | Barium swallow | Endoscopy | Endoscopic ultrasound | 0 | [
"Achalasia"
] | Question: Gold standard Investigation for Achalasia cardia is :
Choices:
A. Esophageal manometry
B. Barium swallow
C. Endoscopy
D. Endoscopic ultrasound
Answer: |
Achalasia cardia | Absence of nerves | Absence of muscles | Hyperophy of nerves | Hyperophy of muscles | 0 | [
"Achalasia"
] | Question: Achalasia cardia
Choices:
A. Absence of nerves
B. Absence of muscles
C. Hyperophy of nerves
D. Hyperophy of muscles
Answer: |
Mode of inheritance forAchondroplasia is - | Autosomal dominant | Autosomal recessive | X-linked dominant | X- linked recessive | 0 | [
"Achondroplasia"
] | Question: Mode of inheritance forAchondroplasia is -
Choices:
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X- linked recessive
Answer: |
The features of Achondroplasia inlcude all,except -a) Defective headb) Mental retardationc) Autosomal recessived) Familial | bc | c | ac | ad | 0 | [
"Achondroplasia"
] | Question: The features of Achondroplasia inlcude all,except -a) Defective headb) Mental retardationc) Autosomal recessived) Familial
Choices:
A. bc
B. c
C. ac
D. ad
Answer: |
Most common inheritance of Achondroplasia is | Sporadic | Autosomal dominant | Autosomal recessive | X-linked recessive | 1 | [
"Achondroplasia"
] | Question: Most common inheritance of Achondroplasia is
Choices:
A. Sporadic
B. Autosomal dominant
C. Autosomal recessive
D. X-linked recessive
Answer: |
Achondroplasia shows which of the following type of inheritance | Autosomal Dominant | Autosomal Recessive | X-Linked Dominant | X-Linked Recessive | 0 | [
"Achondroplasia"
] | Question: Achondroplasia shows which of the following type of inheritance
Choices:
A. Autosomal Dominant
B. Autosomal Recessive
C. X-Linked Dominant
D. X-Linked Recessive
Answer: |
All of the following are features of Achondroplasia except: | Bullet shaped veebra | Trident hand/starfish hand | Wimberger ring sign | Champagne glass pelvis | 2 | [
"Achondroplasia"
] | Question: All of the following are features of Achondroplasia except:
Choices:
A. Bullet shaped veebra
B. Trident hand/starfish hand
C. Wimberger ring sign
D. Champagne glass pelvis
Answer: |
Microcephaly is seen in
Beckwith hypoglycaemic syndrome
Fanconi syndrome
Down syndrome
Achondroplasia | I and iv | I and ii | ii and iii | ii and iv | 1 | [
"Achondroplasia"
] | Question: Microcephaly is seen in
Beckwith hypoglycaemic syndrome
Fanconi syndrome
Down syndrome
Achondroplasia
Choices:
A. I and iv
B. I and ii
C. ii and iii
D. ii and iv
Answer: |
True statement regarding Achondroplasia is : | AR inheritance | Shortened spine | Increased risk of pathological fracture | Diagnosed at birth by X-ray | 3 | [
"Achondroplasia"
] | Question: True statement regarding Achondroplasia is :
Choices:
A. AR inheritance
B. Shortened spine
C. Increased risk of pathological fracture
D. Diagnosed at birth by X-ray
Answer: |
If both husband and wife are suffering with Achondroplasia, what are their chances of having a normal child? | 0% | 25% | 50% | 100% | 1 | [
"Achondroplasia"
] | Question: If both husband and wife are suffering with Achondroplasia, what are their chances of having a normal child?
Choices:
A. 0%
B. 25%
C. 50%
D. 100%
Answer: |
All are true about Achondroplasia except | Antosomal dominant | Acral osteolysis | Trident hand | Champaigne glass pelvis | 1 | [
"Achondroplasia"
] | Question: All are true about Achondroplasia except
Choices:
A. Antosomal dominant
B. Acral osteolysis
C. Trident hand
D. Champaigne glass pelvis
Answer: |
Not a feature of Achondroplasia | Tombstone iliac bone | Champagne glass pelvis | Acromelic dwarfism | Bullet shaped veebra | 2 | [
"Achondroplasia"
] | Question: Not a feature of Achondroplasia
Choices:
A. Tombstone iliac bone
B. Champagne glass pelvis
C. Acromelic dwarfism
D. Bullet shaped veebra
Answer: |
Achondroplasia shows which of the following type of inheritance? | Autosomal dominant | Autosomal recessive | X linked dominant | X linked recessive | 0 | [
"Achondroplasia"
] | Question: Achondroplasia shows which of the following type of inheritance?
Choices:
A. Autosomal dominant
B. Autosomal recessive
C. X linked dominant
D. X linked recessive
Answer: |
The earliest Cranial nerve involved in Acoustic Neuroma is: | V | VI | VII | X | 0 | [
"Acoustic Neuroma"
] | Question: The earliest Cranial nerve involved in Acoustic Neuroma is:
Choices:
A. V
B. VI
C. VII
D. X
Answer: |
Acromegaly is due to excess of: | Somatomedin | Growth hormone | Somatostation | Insulin | 1 | [
"Acromegaly"
] | Question: Acromegaly is due to excess of:
Choices:
A. Somatomedin
B. Growth hormone
C. Somatostation
D. Insulin
Answer: |
Deficiency of growth hormone leads to –a) Delayed fusion of epiphysisb) Proportionate dwarfismc) Acromegaly d) Mental retardation | ac | a | ab | bc | 2 | [
"Acromegaly"
] | Question: Deficiency of growth hormone leads to –a) Delayed fusion of epiphysisb) Proportionate dwarfismc) Acromegaly d) Mental retardation
Choices:
A. ac
B. a
C. ab
D. bc
Answer: |
Acromegaly is associated with all of the following EXCEPT: | Nasal sinus enlargement | Increased heel pad thickness | Diabetes mellitus | Muscle hyperophy | 3 | [
"Acromegaly"
] | Question: Acromegaly is associated with all of the following EXCEPT:
Choices:
A. Nasal sinus enlargement
B. Increased heel pad thickness
C. Diabetes mellitus
D. Muscle hyperophy
Answer: |
Angioid streaks is seen in -a) Pseudoxanthoma Elasticumb) Acromegalyc) Paget's diseased) All of above | a | ac | ad | b | 1 | [
"Acromegaly",
"Pseudoxanthoma Elasticum"
] | Question: Angioid streaks is seen in -a) Pseudoxanthoma Elasticumb) Acromegalyc) Paget's diseased) All of above
Choices:
A. a
B. ac
C. ad
D. b
Answer: |
In Acromegaly All of the following are seen EXCEPT | Visceromegaly | Decreased sweating | Hypertension | Soft tissue and bone enlargement | 1 | [
"Acromegaly"
] | Question: In Acromegaly All of the following are seen EXCEPT
Choices:
A. Visceromegaly
B. Decreased sweating
C. Hypertension
D. Soft tissue and bone enlargement
Answer: |
Confirmatory investigation for Acromegaly is: | Insulin induced GH suppression | Glucose induced GH suppression | Random GH assay | IGF - I level | 1 | [
"Acromegaly"
] | Question: Confirmatory investigation for Acromegaly is:
Choices:
A. Insulin induced GH suppression
B. Glucose induced GH suppression
C. Random GH assay
D. IGF - I level
Answer: |
Acromegaly is a disorder of: | Excess growth hormone secretion during adulthood | Excess thyroxine secretion | Excess ACTH secretion | Excess FSH secretion | 0 | [
"Acromegaly"
] | Question: Acromegaly is a disorder of:
Choices:
A. Excess growth hormone secretion during adulthood
B. Excess thyroxine secretion
C. Excess ACTH secretion
D. Excess FSH secretion
Answer: |
Acromegaly results due to excessive release of: | Thyroxine | Growth hormone | Insulin | Glucagon | 1 | [
"Acromegaly"
] | Question: Acromegaly results due to excessive release of:
Choices:
A. Thyroxine
B. Growth hormone
C. Insulin
D. Glucagon
Answer: |
Acromegaly is associated with | Class. I malocclusion | Class. I cross bite | Class. II malocclusion | Class. III malocclusion | 3 | [
"Acromegaly"
] | Question: Acromegaly is associated with
Choices:
A. Class. I malocclusion
B. Class. I cross bite
C. Class. II malocclusion
D. Class. III malocclusion
Answer: |
Drug used in Acute Intermittent Porphyria is | Opioids | Phenobarbitone | Primidone | Blood tranfusion | 0 | [
"Acute Intermittent Porphyria"
] | Question: Drug used in Acute Intermittent Porphyria is
Choices:
A. Opioids
B. Phenobarbitone
C. Primidone
D. Blood tranfusion
Answer: |
All of the following genetic syndromes are associated with Acute Myeloid Leukemia, except: | Down's Syndrome | Klinefelter's Syndrome | Patau Syndrome | Turner's Syndrome | 3 | [
"Acute Myeloid Leukemia"
] | Question: All of the following genetic syndromes are associated with Acute Myeloid Leukemia, except:
Choices:
A. Down's Syndrome
B. Klinefelter's Syndrome
C. Patau Syndrome
D. Turner's Syndrome
Answer: |
A child with Acute Myeloid Leukemia presents with hyperleukocytosis. Treatment includes all of the following except ? | IV fluid | Allopurinol | Alkalinization | Immediately sta induction chemotherapy | 3 | [
"Acute Myeloid Leukemia"
] | Question: A child with Acute Myeloid Leukemia presents with hyperleukocytosis. Treatment includes all of the following except ?
Choices:
A. IV fluid
B. Allopurinol
C. Alkalinization
D. Immediately sta induction chemotherapy
Answer: |
Which of the following is a poor prognostic factor in Acute Myeloid Leukemia (AML) | Monosomy | Deletion of X or Y chromosome | t (8; 21) translocation | Nucleophosphin mutation | 0 | [
"Acute Myeloid Leukemia"
] | Question: Which of the following is a poor prognostic factor in Acute Myeloid Leukemia (AML)
Choices:
A. Monosomy
B. Deletion of X or Y chromosome
C. t (8; 21) translocation
D. Nucleophosphin mutation
Answer: |
Non-specific esterase is positive in all the categories of Acute Myeloid Leukemia, EXCEPT: | M3 | M4 | M5 | M6 | 0 | [
"Acute Myeloid Leukemia"
] | Question: Non-specific esterase is positive in all the categories of Acute Myeloid Leukemia, EXCEPT:
Choices:
A. M3
B. M4
C. M5
D. M6
Answer: |
The cause of the severe hemorrhage in Acute Promyelocytic Leukemia is? | Disseminated intravascular coagulation | Immune complex deposits on blood vessels | Thrombocytopenia | Thrombocytosis | 0 | [
"Acute Promyelocytic Leukemia"
] | Question: The cause of the severe hemorrhage in Acute Promyelocytic Leukemia is?
Choices:
A. Disseminated intravascular coagulation
B. Immune complex deposits on blood vessels
C. Thrombocytopenia
D. Thrombocytosis
Answer: |
A 26 year old man is critically ill, with multisystem organ failure, and he has not been able to give a clear history of respiratory distress. You suspect Acute Respiratory Distress Syndrome (ARDS). 1. The lung injury may be direct, as occurs in sepsis, or indirect, as occurs in Toxic inhalation 2. The aerial (a) PO2 (in mmHg)/FIO2 (inspiratory O2 fraction) > 200 mmHg is characteristic of ARDS 3. Ventilator-induced injury will be more with low tidal volume ventilation in ARDS 4. Moality was significantly lower in the high tidal volume ventilation, compared to the conventional tidal volume ventilated patients 5. High-dose glucocoicoids are useful in the care of ARDS patients | 1,2,5-True & 3,4-False | All True | All False | 3,4-True & 1,2,5-False | 2 | [
"Acute Respiratory Distress Syndrome"
] | Question: A 26 year old man is critically ill, with multisystem organ failure, and he has not been able to give a clear history of respiratory distress. You suspect Acute Respiratory Distress Syndrome (ARDS). 1. The lung injury may be direct, as occurs in sepsis, or indirect, as occurs in Toxic inhalation 2. The aerial (a) PO2 (in mmHg)/FIO2 (inspiratory O2 fraction) > 200 mmHg is characteristic of ARDS 3. Ventilator-induced injury will be more with low tidal volume ventilation in ARDS 4. Moality was significantly lower in the high tidal volume ventilation, compared to the conventional tidal volume ventilated patients 5. High-dose glucocoicoids are useful in the care of ARDS patients
Choices:
A. 1,2,5-True & 3,4-False
B. All True
C. All False
D. 3,4-True & 1,2,5-False
Answer: |
Diffuse specific lesions on intestinal biopsy are seen in -a) Celiac sprueb) Whipples diseasec) Agammaglobulinemia d) Abetalipoproteinemal | abc | bcd | ac | bd | 1 | [
"Agammaglobulinemia"
] | Question: Diffuse specific lesions on intestinal biopsy are seen in -a) Celiac sprueb) Whipples diseasec) Agammaglobulinemia d) Abetalipoproteinemal
Choices:
A. abc
B. bcd
C. ac
D. bd
Answer: |
Agammaglobulinemia can present with? | Rhinitis | Bronchiectasis | Giardia infections | All above | 3 | [
"Agammaglobulinemia"
] | Question: Agammaglobulinemia can present with?
Choices:
A. Rhinitis
B. Bronchiectasis
C. Giardia infections
D. All above
Answer: |
Diagnosis of X linked Agammaglobulinemia should be suspected if: | Female sex | Absent tonsils and no palpable lymph nodes on physical examination | High isohemagglutinins titers | Low CD3 | 1 | [
"Agammaglobulinemia"
] | Question: Diagnosis of X linked Agammaglobulinemia should be suspected if:
Choices:
A. Female sex
B. Absent tonsils and no palpable lymph nodes on physical examination
C. High isohemagglutinins titers
D. Low CD3
Answer: |
Alkaptonuria an inherited metabolic disorder is due to the deficiency of | Homogentisate oxidase | Cystathionase | Pheylalanine hydroxylase | Tyrosine transaminase | 0 | [
"Alkaptonuria"
] | Question: Alkaptonuria an inherited metabolic disorder is due to the deficiency of
Choices:
A. Homogentisate oxidase
B. Cystathionase
C. Pheylalanine hydroxylase
D. Tyrosine transaminase
Answer: |
Alkaptonuria is caused by defect in which of the following enzymes? | Enolase | Homogentisate oxidase | Pyruvate carboxylase | None of the above | 1 | [
"Alkaptonuria"
] | Question: Alkaptonuria is caused by defect in which of the following enzymes?
Choices:
A. Enolase
B. Homogentisate oxidase
C. Pyruvate carboxylase
D. None of the above
Answer: |
Enzyme-deficient in Alkaptonuria | Phenylalanine hydroxylase | Cystathionine synthase | Homogentisic acid oxidase | Tyrosinase | 2 | [
"Alkaptonuria"
] | Question: Enzyme-deficient in Alkaptonuria
Choices:
A. Phenylalanine hydroxylase
B. Cystathionine synthase
C. Homogentisic acid oxidase
D. Tyrosinase
Answer: |
The earliest manifestation of Alkaptonuria is - | Ankylosis of lumbodorsal spine | Ochronotic arthritis | Prostatic calculi | Pigmentation of tympanic membrane | 1 | [
"Alkaptonuria"
] | Question: The earliest manifestation of Alkaptonuria is -
Choices:
A. Ankylosis of lumbodorsal spine
B. Ochronotic arthritis
C. Prostatic calculi
D. Pigmentation of tympanic membrane
Answer: |
Enzyme deficient in Alkaptonuria? | Phenylalanine hydroxylase | Cystathionine synthase | Homogentisic acid oxidase | Tyrosinase | 2 | [
"Alkaptonuria"
] | Question: Enzyme deficient in Alkaptonuria?
Choices:
A. Phenylalanine hydroxylase
B. Cystathionine synthase
C. Homogentisic acid oxidase
D. Tyrosinase
Answer: |
Which of the following is used to treat Alkaptonuria? | Vitamin A | Vitamin C | Vitamin D | Vitamin K | 1 | [
"Alkaptonuria"
] | Question: Which of the following is used to treat Alkaptonuria?
Choices:
A. Vitamin A
B. Vitamin C
C. Vitamin D
D. Vitamin K
Answer: |
Which substance gets accumulated in abnormal amounts in Alkaptonuria | Acetoacetate | Oxalate | Homogentisate | Phenylacetic acid | 2 | [
"Alkaptonuria"
] | Question: Which substance gets accumulated in abnormal amounts in Alkaptonuria
Choices:
A. Acetoacetate
B. Oxalate
C. Homogentisate
D. Phenylacetic acid
Answer: |
Which is false about Alkaptonuria? | Genitourinary system not involved | Hemogentistic oxidase deficiency | Black urine | Calcification in veebral bodies | 0 | [
"Alkaptonuria"
] | Question: Which is false about Alkaptonuria?
Choices:
A. Genitourinary system not involved
B. Hemogentistic oxidase deficiency
C. Black urine
D. Calcification in veebral bodies
Answer: |
Treatment of Alkaptonuria: | Vitamin A | Vitamin C | Vitamin D | Vitamin K | 1 | [
"Alkaptonuria"
] | Question: Treatment of Alkaptonuria:
Choices:
A. Vitamin A
B. Vitamin C
C. Vitamin D
D. Vitamin K
Answer: |
Enzyme deficiency in Alkaptonuria is | Tyrosine hydroxylase | Homogentisate acid oxidase | Phenyl alanine hydroxylase | Cystathione synthase | 1 | [
"Alkaptonuria"
] | Question: Enzyme deficiency in Alkaptonuria is
Choices:
A. Tyrosine hydroxylase
B. Homogentisate acid oxidase
C. Phenyl alanine hydroxylase
D. Cystathione synthase
Answer: |
In Alkaptonuria deficiency is: | Phosphofructo kinase | HMG CoA reductase | Homogentisate oxidase | Xanthine oxidase | 2 | [
"Alkaptonuria"
] | Question: In Alkaptonuria deficiency is:
Choices:
A. Phosphofructo kinase
B. HMG CoA reductase
C. Homogentisate oxidase
D. Xanthine oxidase
Answer: |
Alkaptonuria is a metabolic disease caused by a defect in or lack of homogentisic acid oxidase which lead to | Absent patella | Blue sclera | Darkly pigmented sclera cornea & ear | Absent radii | 2 | [
"Alkaptonuria"
] | Question: Alkaptonuria is a metabolic disease caused by a defect in or lack of homogentisic acid oxidase which lead to
Choices:
A. Absent patella
B. Blue sclera
C. Darkly pigmented sclera cornea & ear
D. Absent radii
Answer: |
Calcification of intervertebral disc is seen in – a) Goutb) Rheumatoid c) Alkaptonuriad) Psoriasis | ac | bc | ad | b | 0 | [
"Alkaptonuria"
] | Question: Calcification of intervertebral disc is seen in – a) Goutb) Rheumatoid c) Alkaptonuriad) Psoriasis
Choices:
A. ac
B. bc
C. ad
D. b
Answer: |
Alkaptonuria is due to deficiency of | Alkaptonase | Tyrosinase | Phenylalanine hydroxylase | Homogentisic acid oxidase | 3 | [
"Alkaptonuria"
] | Question: Alkaptonuria is due to deficiency of
Choices:
A. Alkaptonase
B. Tyrosinase
C. Phenylalanine hydroxylase
D. Homogentisic acid oxidase
Answer: |
All of the following are used in Alopecia Areata except | Tacrolimus | Acitretin | Steroids | Phototherapy | 1 | [
"Alopecia Areata"
] | Question: All of the following are used in Alopecia Areata except
Choices:
A. Tacrolimus
B. Acitretin
C. Steroids
D. Phototherapy
Answer: |
Which one of the following is NOT true of Ameloblastoma - | Most common odontogenic tumour | Generally benign | Common in 3rd to 5th decade | Arises from mesenchymal tissue | 3 | [
"Ameloblastoma"
] | Question: Which one of the following is NOT true of Ameloblastoma -
Choices:
A. Most common odontogenic tumour
B. Generally benign
C. Common in 3rd to 5th decade
D. Arises from mesenchymal tissue
Answer: |
True about Ameloblastoma: (PGI Dec 2006) | Cystic lesion | Rapidly growing | Malignant disease | MC site is Tibia | 0 | [
"Ameloblastoma"
] | Question: True about Ameloblastoma: (PGI Dec 2006)
Choices:
A. Cystic lesion
B. Rapidly growing
C. Malignant disease
D. MC site is Tibia
Answer: |
Ameloblastoma most frequently occurs in | Mandibular molar region | Maxillary molar region | Mandibular premolar region | Maxillary premolar region | 0 | [
"Ameloblastoma"
] | Question: Ameloblastoma most frequently occurs in
Choices:
A. Mandibular molar region
B. Maxillary molar region
C. Mandibular premolar region
D. Maxillary premolar region
Answer: |
True about Ameloblastoma -a) Cystic lesionb) Rapidly growingc) Malignant diseased) MC site is Tibiae) Presented in children | ae | b | ab | ad | 0 | [
"Ameloblastoma"
] | Question: True about Ameloblastoma -a) Cystic lesionb) Rapidly growingc) Malignant diseased) MC site is Tibiae) Presented in children
Choices:
A. ae
B. b
C. ab
D. ad
Answer: |
Congo red staining of abdominal fat has confirmed a diagnosis of Amyloidosis in a 28-year-old man. Which is the most common cause of death in primary AL Amylodosis? | Respiratory failure | Cardiac failure | Renal failure | Septicemia | 1 | [
"Amyloidosis"
] | Question: Congo red staining of abdominal fat has confirmed a diagnosis of Amyloidosis in a 28-year-old man. Which is the most common cause of death in primary AL Amylodosis?
Choices:
A. Respiratory failure
B. Cardiac failure
C. Renal failure
D. Septicemia
Answer: |
Amyloidosis of hea presents with - | Arrhythmia | AV block | |Ed mass/voltage | AS | 0 | [
"Amyloidosis"
] | Question: Amyloidosis of hea presents with -
Choices:
A. Arrhythmia
B. AV block
C. |Ed mass/voltage
D. AS
Answer: |
Which type of Amyloidosis is caused by mutation of the transthyretin protein ?- | Familial Mediterranean fever | Familial amyloidotic polyneuropathy | Dialysis associated amyloidosis | Prion protein associated amyloidosis | 1 | [
"Amyloidosis"
] | Question: Which type of Amyloidosis is caused by mutation of the transthyretin protein ?-
Choices:
A. Familial Mediterranean fever
B. Familial amyloidotic polyneuropathy
C. Dialysis associated amyloidosis
D. Prion protein associated amyloidosis
Answer: |
Amyloidosis is most commonly seen in ? | Maturity onset DM | Type I DM | Type H DM | HTN | 2 | [
"Amyloidosis"
] | Question: Amyloidosis is most commonly seen in ?
Choices:
A. Maturity onset DM
B. Type I DM
C. Type H DM
D. HTN
Answer: |
Amyloidosis is commonly associated with: | Chronic osteomyelitis | Periostitis | Acute osteomyelitis | Multiple myeloma | 3 | [
"Amyloidosis"
] | Question: Amyloidosis is commonly associated with:
Choices:
A. Chronic osteomyelitis
B. Periostitis
C. Acute osteomyelitis
D. Multiple myeloma
Answer: |
Amyloidosis causes which type of cardiomyopathy? | Constrictive | Restrictive | Hypertrophic | Any of the above | 1 | [
"Amyloidosis"
] | Question: Amyloidosis causes which type of cardiomyopathy?
Choices:
A. Constrictive
B. Restrictive
C. Hypertrophic
D. Any of the above
Answer: |
Polyneuropathy is seen in -a) Vitamin deficiencyb) Osteoporosisc) DMd) Myxoedemae) Amyloidosis | bce | acde | abcd | abde | 1 | [
"Amyloidosis"
] | Question: Polyneuropathy is seen in -a) Vitamin deficiencyb) Osteoporosisc) DMd) Myxoedemae) Amyloidosis
Choices:
A. bce
B. acde
C. abcd
D. abde
Answer: |
Amyloidosis is seen in which type of diabetes mellitus? | Maturity onset DM | Type I DM | Type II DM | all of the above | 2 | [
"Amyloidosis"
] | Question: Amyloidosis is seen in which type of diabetes mellitus?
Choices:
A. Maturity onset DM
B. Type I DM
C. Type II DM
D. all of the above
Answer: |
Small intestinal biopsy is specific for-a) Tropical sprueb) Celiac spruec) Whipple's diseased) Amyloidosis | cd | bc | bd | ac | 0 | [
"Amyloidosis"
] | Question: Small intestinal biopsy is specific for-a) Tropical sprueb) Celiac spruec) Whipple's diseased) Amyloidosis
Choices:
A. cd
B. bc
C. bd
D. ac
Answer: |
Amyloidosis mostly affects | Liver | Tounge | Colon | Hea | 3 | [
"Amyloidosis"
] | Question: Amyloidosis mostly affects
Choices:
A. Liver
B. Tounge
C. Colon
D. Hea
Answer: |
Confirmatory test for the diagnosis ofAmyloidosis is? | Diagnostic peritoneal lavage | Tongue biopsy | Rectal biopsy | Whole body CT scan | 2 | [
"Amyloidosis"
] | Question: Confirmatory test for the diagnosis ofAmyloidosis is?
Choices:
A. Diagnostic peritoneal lavage
B. Tongue biopsy
C. Rectal biopsy
D. Whole body CT scan
Answer: |
Amyloidosis shown in Cardiac muscle is mainly due to …….. fibril | AL | AA | AANF | ATTR | 3 | [
"Amyloidosis"
] | Question: Amyloidosis shown in Cardiac muscle is mainly due to …….. fibril
Choices:
A. AL
B. AA
C. AANF
D. ATTR
Answer: |
Major fibril protein in Primary Amyloidosis is ? | AL | AA | Transthyretin | Procalciton | 0 | [
"Amyloidosis"
] | Question: Major fibril protein in Primary Amyloidosis is ?
Choices:
A. AL
B. AA
C. Transthyretin
D. Procalciton
Answer: |
Major fibril protein in Primary Amyloidosis is - | AL | AA | Transthyretin | Procalcitonin | 0 | [
"Amyloidosis"
] | Question: Major fibril protein in Primary Amyloidosis is -
Choices:
A. AL
B. AA
C. Transthyretin
D. Procalcitonin
Answer: |
Confirmatory test for the diagnosis of Amyloidosis- | Diagnostic peritoneal lavage | Tongue biopsy | Rectal biopsy | Whole body CT scan | 2 | [
"Amyloidosis"
] | Question: Confirmatory test for the diagnosis of Amyloidosis-
Choices:
A. Diagnostic peritoneal lavage
B. Tongue biopsy
C. Rectal biopsy
D. Whole body CT scan
Answer: |
Confirmatory test for the diagnosis of Amyloidosis is: | Diagnostic peritoneal lavage | Tongue biopsy | Rectal biopsy | Whole body CT scan | 2 | [
"Amyloidosis"
] | Question: Confirmatory test for the diagnosis of Amyloidosis is:
Choices:
A. Diagnostic peritoneal lavage
B. Tongue biopsy
C. Rectal biopsy
D. Whole body CT scan
Answer: |
Amyloidosis of heart presents with -a) Arrhythmiab) AV blockc) ↑ed mass/voltage d) Hypertrophic cardiomyopathy | ab | abc | acd | bcd | 1 | [
"Amyloidosis"
] | Question: Amyloidosis of heart presents with -a) Arrhythmiab) AV blockc) ↑ed mass/voltage d) Hypertrophic cardiomyopathy
Choices:
A. ab
B. abc
C. acd
D. bcd
Answer: |
Amyloidosis is most commonly seen in- | Maturity onset DM | Type I DM | Type II DM | HTN | 2 | [
"Amyloidosis"
] | Question: Amyloidosis is most commonly seen in-
Choices:
A. Maturity onset DM
B. Type I DM
C. Type II DM
D. HTN
Answer: |
Which type ofAmyloidosis is caused by mutation of the transthyretin protein ? | Familial Mediterranean fever | Familial amyloidotic polyneuropathy | Dialysis associated amyloidosis | Prion protein associated amyloidosis | 1 | [
"Amyloidosis"
] | Question: Which type ofAmyloidosis is caused by mutation of the transthyretin protein ?
Choices:
A. Familial Mediterranean fever
B. Familial amyloidotic polyneuropathy
C. Dialysis associated amyloidosis
D. Prion protein associated amyloidosis
Answer: |
Amyloidosis is most commonly seen in | Maturity onset DM | Type1DM | Type2DM | Equally seen with all forms of DM | 2 | [
"Amyloidosis"
] | Question: Amyloidosis is most commonly seen in
Choices:
A. Maturity onset DM
B. Type1DM
C. Type2DM
D. Equally seen with all forms of DM
Answer: |
Amyloidosis is? | RNA misfolding | DNA repair defect | Mitochondrial defect | Misfolding of protein | 3 | [
"Amyloidosis"
] | Question: Amyloidosis is?
Choices:
A. RNA misfolding
B. DNA repair defect
C. Mitochondrial defect
D. Misfolding of protein
Answer: |
Paraneoplastic syndrome not seen in renal cell cancer is?a) Acanthosis nigricansb) Amyloidosisc) Polycythemiad) SLE | b | c | ad | ab | 2 | [
"Amyloidosis"
] | Question: Paraneoplastic syndrome not seen in renal cell cancer is?a) Acanthosis nigricansb) Amyloidosisc) Polycythemiad) SLE
Choices:
A. b
B. c
C. ad
D. ab
Answer: |
Bone marrow in Amyloid Lightchain Amyloidosis shows which of the following features? | Bone marrow plasmacytosis | Granulomatous reaction | Fibrosis | Giant cell formation | 0 | [
"Amyloidosis"
] | Question: Bone marrow in Amyloid Lightchain Amyloidosis shows which of the following features?
Choices:
A. Bone marrow plasmacytosis
B. Granulomatous reaction
C. Fibrosis
D. Giant cell formation
Answer: |
Amyloidosis deposition most commonly occurs in: | Renal vessels | Knee joints | Skin | Cornea | 0 | [
"Amyloidosis"
] | Question: Amyloidosis deposition most commonly occurs in:
Choices:
A. Renal vessels
B. Knee joints
C. Skin
D. Cornea
Answer: |
Amyloidosis most commonly affects - | Liver | Tongue | Colon | Hea | 3 | [
"Amyloidosis"
] | Question: Amyloidosis most commonly affects -
Choices:
A. Liver
B. Tongue
C. Colon
D. Hea
Answer: |
Which type of Amyloidosis is caused by the mutation of a transthyretin protein? | Dialysis associated amyloidosis | Familial Mediterranean fever | Familial amyloidotic polyneuropathy | Prion protein associated amyloidosis | 2 | [
"Amyloidosis"
] | Question: Which type of Amyloidosis is caused by the mutation of a transthyretin protein?
Choices:
A. Dialysis associated amyloidosis
B. Familial Mediterranean fever
C. Familial amyloidotic polyneuropathy
D. Prion protein associated amyloidosis
Answer: |
Dataset Card for ReDis-QA
Dataset Summary
ReDis-QA dataset contains 1360 multi-choice questions focusing on rare disease diagnosis. It consists of 11%, 33%, 13%, 15%, 18% of the questions corresponding to the symptoms, causes, affects, related-disorders, diagnosis of rare diseases, respectively. The remaining 9% of the questions pertain to other properties of the diseases.
ReDis-QA dataset widely covers 205 types of rare diseases, where the most frequent disease features over 100 questions.
Belows are examples of each property.
Property | Example |
---|---|
Symptom | Question: About Achalasia Cardia: 1. Dysphagia is a presenting symptom 2. The cause is the absence of Auerbach's plexus 3. Esophagec-tomy is the treatment 4. Motility improving agents are used in treatment 5. Barium swallow shows irregular filling defects in lower esophagus Choices: (A) 1,2,3 False & 4,5 True (B) 1,2,4 True & 3,5 False (C) 2,3,4 True & 1,5 False (D) 1,3,5 True & 2,4 False Golden Answer: B |
Causes | Question: A mother brings her 1-year-old daughter to the physician. She says that for the last 2 days her daughter has been fussy and crying more than usual. She also refuses formula. The patient has a fever of 39.4degC (102.9degF). Meningitis is suspected, and a lumbar puncture is performed. Analysis of the cerebrospinal fluid shows an opening pressure of 98 mm H2O, a leukocyte count of 1256/mm3, a protein level of 210 mg/dL, and a glucose level of 31 mg/dL. The mother says that the patient has received no immunizations. Which of the following organisms is most likely responsible for this patient's illness? Choices: (A) Clostridium botulinum (B) Haemophilus influenza (C) Neisseria meningitides (D) Streptococcus pneumonia Golden Answer: B |
Affects | Question: 23 years old female comes to OG, because she thinks pregnant. She missed her last two cycles and she feels different. Urine pregnancy test was positive. On USG, the pregnancy was confirmed to be 12 weeks. She is very concerned because she received Measles Mumps Rubella vaccine 4 months ago and she was told to wait for 3 months to conceive. The pregnancy is desired. The most appropriate step is Choices: (A) Vaccine risk is minimal, not itself a reason to terminate the pregnancy. (B) Vaccine risk is nil, termination is completely inappropriate. (C) Vaccine risk is high, termination should be strongly considered. (D) Vaccine risk is high, termination is mandated. Golden Answer: A |
Related-disorders | Question: A 35-year-old female presented to the medicine OPD with paresthesias and weakness of B/L lower limbs with a band like sensation of tightness around the torso along with painful loss of vision in both eyes along with diplopia and periorbital pain.} There is a history of similar attacks in the past with period of normalcy in between O/E, Ataxia- present Papillitis (on fundus examination) Facial myokymia Bladder incontinence and constipation CSF studies revealed mononuclear cell pleocytosis along with increased IgG. Which of the following are the oral drugs approved for the above condition: 1. Fingolimod 2. Natalizumab 3. Teriflunomide 4. Glatiramer acetate Choices: (A) Only 1 (B) Both 1 and 3 (C) 1,2 and 3 (D) All of the above Golden Answer: A |
Diagnosis | Question: A 29-year-old man is seen in the office after returning from a hiking trip in Colorado. He complains of feeling unwell and reports symptoms of fever, myalgia, headache, and nausea. Two days ago, he noticed a rash on his wrists and ankles that has now spread to his body. He recalls having had numerous insect bites during his trip. On examination, his blood pressure is 90/60 mmHg, pulse 100/min, and respira- tions 20/min. There are multiple 1-5 mm macules on his body and some of them have a hemorrhagic center consistent with a petechia. His neck is supple and fundi are normal. The heart sounds are normal, lungs clear, and legs are edematous. Cranial nerve, motor, and sensory examination is normal. A clinical diagnosis of Rocky Mountain Spotted Fever (RMSF) is made and he is started on appropriate therapy. Which of the following is the most common type of central nervous system (CNS) presentation in this condition? Choices: (A) Hemiplegia (B) Cranial nerve abnormalities (C) Paraplegia (D) Encephalitis Golden Answer: D |
Loading Dataset
Simply follow the instructions to test your models on the ReDis-QA dataset:
import datasets
eval_dataset = datasets.load_dataset(f"guan-wang/ReDis-QA")
for data_idx, data_instance in enumerate(eval_dataset):
print(data_idx, data_instance["input"])
Benchmark Results of LLMs
Benchmark results of Llama-2-7B-chat, Mistral-7B-instruct-v0.2, Phi-3-7B-instruct, Gemmma-1.1-7B-it, and Qwen-2-7B-Instruct. More details refers to our benchmark repository ReDis-QA-Bench.
Citation Information
If you find this dataset useful to your project, we appreciate you citing this work:
@article{wang2024assessing,
title={Assessing and Enhancing Large Language Models in Rare Disease Question-answering},
author={Wang, Guanchu and Ran, Junhao and Tang, Ruixiang and Chang, Chia-Yuan and Chuang, Yu-Neng and Liu, Zirui and Braverman, Vladimir and Liu, Zhandong and Hu, Xia},
journal={arXiv preprint arXiv:2408.08422},
year={2024}
}
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