Patent Abstract:
it is the embodiment of this invention to form novel compositions of indoleamines e . g . 5 - hydroxytryptophan and / or catecholamines e . g . l - dopa with the gallocatechins e . g . epigallocatechin3 - o - gallate and / or epigallocatechin or any of the catechins found in green tea in a pharmaceutical or nutritional dosage or dietary regimen be it in tablet , liquid , capsule , injectable or any other ingestible form to achieve enhanced bioavailability and a superior safety profile .

Detailed Description:
as a supplement to the brief description above we have as follows : this invention relates to a novel method for inhibiting the ubiquitious enzyme aromatic amino acid decarboxylase hereinafter referred to as ( aadc ) via non - pharmaceutical moieties the applications of said invention span a broad range , including but not limited to depression , parkinson &# 39 ; s disease , weight loss etc , the discussion and examples set forth herein with regard to 5 - hydroxytryptophan ( 5 - htp ) can be analogously used with regard to l - dopa the conversion of ( 5 - htp ) to serotonin via ( aadc ) is shown in diagram 1 to avoid its conversion to serotonin in the periphery several pharmaceutical ( s ) have been found which in combination inhibit ( aadc ) so as to allow serotonin conversion in the central nervous system ( cns ) i . e . carbidopa and benserazide the galloatachins referred to in the abstract (−) epigallocatechin - 3 - o - gallate ( egcg ) and / or (−) epigallocatechin ( egc ) have such properties . surprisingly in the two clinicals ( example 1 and 2 below ) the combination showed superiority to the pharmaceutical combinations in these respects 1 . lower serotonin content in the circulatory system 2 . less side affects 3 . lower measured amounts of the key negative metabolic indicator 5 - hydroxyindole acetic acid 4 . indications of a preferable metabolic time - profile consistent with the desired peripheral decarboxylation example 1 — 10 subjects were given a tablet twice a day for five days containing 50 mg ( 5 - htp ), 90 mg ( egcg )/( ecgc ), 100 mg tyrosine ang 100 mg phenylalanine example 2 — same as 1 but duration of dosaging was for 15 days ! . cangiano c , laviano a , del ben m , et al . effects of oral 5 - hydroxy - tryptophan on energy intake and macronutrient selection in non - insulin dependent diabetic patients . int j obes relat metab disord . 1998 july ; 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284 ( 1 ): 90 - 3 \\\\