Patent Abstract:
a dietary supplement is created , comprised of material from the following nutrients , vitamins , herbs , minerals , and food and plant substances and food and plant derivatives : lycopene , vitamin e , selenium , green tea , coenzyme q10 , garlic , folic acid , vitamin c , curcumin , seaweed , cordyceps sinsensis mushroom , lentinus edodes mushroom , and ganoderma lucidum mushroom . the composition is administered orally for individuals who wish to reduce their risk of disease , particularly cancer - risk .

Detailed Description:
in this invention , ingredients were specifically chosen and combined according to their individual science , peer - reviewed journal support for a role in disease prevention , particularly cancer prevention , related to one or more of the etiologic domains of interest affecting cancer development . although each ingredient selected for the preferred embodiment has been used before for possible cancer prevention and cancer risk reduction , their total combination as a holistic approach for cancer prevention is a new concept . the individual ingredients were selected because there is scientific evidence to indicate they each possess one or more of the following biologic etiologic disease - prevention , cancer - prevention activities : ( 1 ) anti - tumor activity , ( 2 ) immune stimulating activity , ( 3 ) anti - viral activity , ( 4 ) anti - inflammatory activity , ( 5 ) antimutagenic activity , ( 6 ) antiproliferative activity , and ( 7 ) anti - free - radical development activity . since each ingredient may exhibit one or more of the following attributes , we present key scientific data for each ingredient , organized by ingredient . 1 . ames , b . n ., shigenaga , m . k ., hagen , t . m . oxidants , antioxidants , and the degenerative diseases of aging . proc . natl . acad . sci . usa . 90 : 7915 - 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60 , 1995 . 1 . ames , b . n ., shigenaga , m . k ., hagen , t . m . oxidants , antioxidants , and the degenerative diseases of aging . proc . natl . acad . sci . usa . 90 : 7915 - 7922 , sep . 1993 . 2 . berwick , m ., schantz , s . chemoprevention of aerodigestive cancer . cancer metastasis rev . 16 ( 3 - 4 ): 329 - 47 , sep .- dec . 1997 . 3 . blot , w . j ., li , j . y ., taylor , p . r ., guo , w ., dawsey , s ., wang , g - q ., yang , c . s ., zheng , s - f ., gail , m ., li , g - y ., y , y ., liu , b ., tangrea , j ., sun , y ., fraumeni , j . f ., jr ., zhang , y - h ., li , b . nutrition intervention trials in linxian , china : supplementation with specific vitamin / mineral combinations , cancer incidence , and disease - specific mortality in the general population . j natl cancer inst . 85 ( 18 ): 1483 - 1492 , 1993 . 4 . boone , c . w ., kelloff , g . j ., biomarker end - points in cancer chemopreventive trials . iarc sci publ . 142 : 273 - 80 , 1997 . 5 . byers , t ., guerrero , n . epidemiologic evidence for vitamin c and vitamin e in cancer prevention . am j clin nutr . 62 ( suppl ): 1385s - 92s , 1995 . 6 . gey , k f . cardiovascular disease and vitamins . concurrent correction of ‘ suboptimal ’ plasma antioxidant levels may , as important part of ‘ optimal ’ nutrition , help to prevent early stages of cardiovascular disease and cancer , respectively . bibl nutr dieta . 52 : 75 - 91 , 1995 . 7 . gey , k . f . vitamins e plus c and interacting conutrients required for optimal health . a critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer . biofactors . 7 ( 1 - 2 ): 113 - 74 , 1998 . 8 . gey , k . f ., moser , u . k ., jordan , p ., stahelin , h . b ., eichholzer , m ., ludin , e . increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants : an epidemiological update with special attention to carotene and vitamin c . am j clin nutr . 57 ( suppl ): 787s - 97s , 1993 . 9 . giovannucci , e ., stampfer , m . j ., colditz , g . a ., hunter , d . j ., fuchs , c ., rosner , b . a ., speizer , f . e ., willett , w . c . multivitamin use , folate , and colon cancer in women in the nurses &# 39 ; health study . ann intern med . 129 : 517 - 524 , 1998 . 10 . knekt , p . vitamin e and cancer : epidemiology . ann ny acad sci . 30 : 269 - 279 , 1992 . 11 . kristal , a . r ., stanford , j . l ., cohen , j . h ., wicklund , k ., patterson , r . e . vitamin and mineral supplement use is associated with reduced risk of prostate cancer . cancer epidemiol biomarkers prev . 8 ( 10 ): 887 - 92 , oct . 1999 . 12 . kumar , n . b ., besterman - dahan , k . nutrients in the chemoprevention of prostate cancer : current and future prospects . cancer control . 6 ( 6 ): 580 - 586 , nov .- dec . 1999 . 13 . patterson , r . e ., white , e ., kristal a . r ., neuhouser , m . l ., potter , j . d . vitamin supplements and cancer risk : the epidemiologic evidence . cancer causes control . 8 ( 5 ): 786 - 802 , sep . 1997 . 14 . prasad , k . n ., kumar , a ., kochupillai , v ., cole , w . c . high doses of multiple antioxidant vitamins : essential ingredients in improving the efficacy of standard cancer therapy . j am college nutr . 18 ( 1 ): 13 - 25 , 1999 . 15 . shibata , a ., paganini - hill , r . k . r ., henderson , b . e . intake of vegetables , fruits , beta carotene , vitamin c and vitamin supplements and cancer incidence among the elderly : a prospective study . br j cancer . 66 : 673 - 679 , 1992 . 16 . slattery , m . l ., potter , j . d ., coates , a ., ma , k - n ., berry , t . d ., duncan , d . m ., caan , b . j . plant foods and colon cancer : an assessment of specific foods and their related nutrients ( united states ). cancer causes control . 8 : 575 - 590 , 1997 . 17 . stahelin , h . b ., gey , k . f ., eichholzer , m ., ludin , e ., bernasconi , f ., thurneysen , j ., brubacher , g . plasma antioxidant vitamins and subsequent cancer mortality in the 12 - year follow - up of the prospective basel study . am j epidemiol . 133 : 766 - 75 , 1991 . 18 . thomas , j . a . diet , micronutrients , and the prostate gland . nutr rev . 57 ( 4 ): 95 - 103 , apr . 1999 . 19 . woodson , k ., tangrea , j . a ., barrett , m . j ., virtamo , j ., taylor , p . r ., albanes , d . serum α - tocopherol and subsequent risk of lung cancer among male smokers . j natl cancer inst . 91 ( 20 ): 1738 - 1743 , oct . 1999 . 20 . zhang , s ., hunter , d . j ., forman , m . r ., rosner , b . a ., speizer , f . e ., colditz , g . a ., manson , j . e ., hankinson , s . e ., willett , w . c . dietary carotenoids and vitamins a , c , and e and risk of breast cancer . j natl cancer inst . 91 : 547 - 56 , 1999 . 21 . zheng , w ., sellers , t . a ., doyle , t . j ., kushi , l . h ., potter , j . d ., folsom , a . r . retinol , antioxidant vitamins , and cancers of the upper digestive tract in a prospective cohort study of postmenopausal women . am j epidemiol . 142 ( 9 ): 955 - 60 , 1995 . 22 . young , k . j ., lee , p . n . intervention studies on cancer . eur j cancer prev . 8 ( 2 ): 91 - 102 , apr . 1999 . the dosages of the individual ingredients are relative to the level of cancer risk identified in the process , and the range of quantities is approximated below : lycopene — 2 - 20 mg ; vitamin e — 50 - 800 iu ; selenium — 25 - 400 mcg ; green tea — 75 - 600 mg of green tea polyphenols ; coenzyme - q10 — 3 . 75 - 60 mg ; garlic 50 - 700 mg ; folic acid — 50 - 800 mcg ; vitamin c — 60 - 1000 mg ; curcumin — 25 - 400 mg ; soy isoflavones — 2 . 5 - 44 mg ; seaweed — 25 - 400 mg . ; cordyceps sinsensis 50 - 800 mg ; lentinus edodes ( shiitake ) 50 - 800 mg ; and ganoderma lucidum ( reishi ) 50 - 800 mg . a preferred formulation of the nutraceutical of the invention is prepared using lycopene , vitamin e , selenium , green tea polyphenols , coenzyme q - 10 , garlic , folic acid , vitamin c , curcumin , soy isoflavones , seaweed , cordyceps sinsensis mushroom , lentinus edodes ( shiitake ) mushroom , and ganoderma lucidum ( reishi ) mushroom . in one implementation , the ingredients were purchased by ives formulation , inc . in powdered form based on the preferred embodiment of the dietary supplement formulation , each individual ingredient obtained from various suppliers to that pharmaceutical firm , and were combined into a powder mix and then placed in capsules for ingestion .