Patent Abstract:
Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

Full Description:
This is a continuation-in-part of U.S. application Ser. No. 446,901, filed Dec. 6, 1989, which application issued Sept. 18, 1990, as U.S. Pat. No. 4,957,921. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention relates to novel substituted cyclohexanols and cyclohexylamines and derivatives thereof useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to pharmaceutical methods of treatment. The novel compounds of the present invention are central nervous system agents. More particularly, the novel compounds of the present invention are dopaminergic agents. 
     A series of 1-(4-arylcyclohexyl)piperidines which may structurally be represented by the formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein 
     Ar 1  is a member selected from the group consisting of aryl and 1,3-benzodioxolyl; 
     R is a member selected from the group consisting of hydrogen and lower alkyl; 
     R 1  is a member selected from the group consisting of hydrogen, cyano, carboxyl, lower alkyloxycarbonyl, aryllower alkyloxycarbonyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, mono- and di(aryllower alkyl)aminocarbonyl, (aryllower alkyl)lower alkylamino carbonyl, hydroxy, lower alkyloxy, lower alkylcarbonyloxy, formyl, lower alkylcarbonyl, arylcarbonyl, aryllower alkylcarbonyl, lower alkyl, lower alkenyl, lower alkynyl and cyclohexyl; and 
     A is a bivalent radical, having the formula ##STR2##  wherein R 2  and R 3  are each independently selected from the group consisting of hydrogen, halo, trifluoromethyl, lower alkyl, and lower alkyloxy; or 
     A is a bivalent radical, having the formula ##STR3##  wherein Ar 2  is aryl, and 
     R 4  is a member selected from the group consisting of hydrogen, lower alkyl, aryllower alkyl, cyanolower alkyl, aminolower alkyl, mono- and di(lower alkyl) aminolower alkyl, mono- and di(aryllower alkyl)aminolower alkyl, [(aryllower alkyl)lower alkylamino]lower alkyl, hydroxylower alkyl, mercaptolower alkyl, lower alkyloxylower alkyl, lower alkylthiolower alkyl, aryloxylower alkyl, arylthiolower alkyl, aryllower alkyloxylower alkyl, aryllower alkylthiolower alkyl, and a radical of formula ##STR4##  wherein n is 0 or an integer of from 1 to 6 inclusive, Q is O, S or NR 6 , p is 0 or 1, X is O or S, R 5  is hydrogen, lower alkyl, aryl or aryllower alkyl, m is 0 or 1 and Y is O, S or NR 6 , wherein R 6  as used in the definition of Q and Y is hydrogen, lower alkyl, aryl or aryllower alkyl; 
     provided that when Y is O and m and p are each 1, then R 5  is other than hydrogen and provided that when p is 1 then n is other than 0; 
      wherein aryl is a member selected from the group consisting of phenyl, thienyl, pyridinyl, naphthalenyl and substituted phenyl, said substituted phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, phenyl lower alkyloxy, trifluoromethyl, nitro, amino and hydroxy are disclosed in U.S. Pat. No. 4,329,353 as having psychotropic and antiemetic activity. 
     A series of 4-alkoxy-4-(substituted phenyl)cyclohexylamines of formula ##STR5##  where the   sign indicates the cis or trans configuration with the condition that when the R 3  O bond is cis with respect to the amino group the bond joining the phenyl and cyclohexyl rings is trans and vice versa; R=1-4C alkyl, Cl, F, Br, CFs, or 1-4C alkoxy; R&#39;=R or H; R 1  =H or 1-4C alkyl; R 2  =H, 1-4C alkyl, aroylalkyl (monosubstituted on the aryl ring by a group R or 6-10C aryl) or bis-arylalkyl (monosubstituted on the ring by a group R&#39; or 6-10C aryl) or R 1  and R 2  together with the N atom form a saturated heterocyclic chosen from pyrrolidino, piperidino, hexamethyleneimino, morpholino, and piperazino (optionally monosubstituted); R 3  =1-4C. alkyl; are disclosed in Belgium Patent 790836 as having central nervous system depressant activity. 
     However, the 1-(4-arylcyclohexyl)piperidines disclosed in U.S. Pat. No. 4,329,353 and the 4-alkoxy-4-(substituted phenyl)-cyclohexylamines disclosed in Belgium Patent 790836 do not disclose or suggest the combination of structural variations of the compounds of the present invention described hereinafter. 
     SUMMARY OF THE INVENTION 
     Accordingly, the present invention is a compound of Formula I ##STR6## wherein R is --OR 3 , wherein R 3  is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl lower alkyl, lower alkanoyl, aroyl, or aryl lower alkanoyl, ##STR7##  wherein R 4  and R 5  are each independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aryl lower alkyl, heteroaryl lower alkyl, lower alkanoyl, cycloalkanoyl, cycloalkylalkanoyl, aryl lower alkanoyl, heteroaryl lower alkanoyl, aroyl, heteroaroyl, or R 4  and R 5  are taken together with the nitrogen atom to which they are attached to form a ring denoted by ##STR8## wherein p is zero or an integer from 1 to 4 and R 6  is hydrogen, lower alkyl, cycloalkyl, or cycloalkylalkyl ##STR9##  wherein X is oxygen or sulfur or ##STR10##  wherein R 6  is as defined above, or ##STR11##  wherein R 4  and R 5  are each independently hydrogen, lower alkyl, cycloalkyl, cycloalkylaklkyl, aryl, aryl lower alkyl, lower alkanoyl, aryl lower alknaoyl, aroyl, or R 4  and R 5  are taken together with the oxygen and nitrogen atoms to which they are attached to form a ring denoted by ##STR12##  wherein q is an integer from 2 to 3 and R 6  is as defined above; 
     m is zero or an integer from 1 to 2; 
     R 1  is hydrogen, aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2-or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; n is zero or an integer from 1 to 4; R 2  is ##STR13##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof. 
     As dopaminergic agents, the compounds of Formula I are useful as antipsychotic agents for treating psychoses such as schizophrenia. They are also useful as antihypertensives and for the treatment of disorders which respond to dopaminergic activation. Thus, other embodiments of the present invention include the treatment, by a compound of Formula I, of hyperprolactinaemia-related conditions, such as galactorrhea, amenorrhea, menstrual disorders and sexual dysfunction, and several central nervous system disorders such as Parkinson&#39;s disease, Huntington&#39;s chorea, and depression. In addition, like many known antipsychotics, these compounds are high affinity ligands for the central nervous system sigma binding site. 
     A still further embodiment of the present invention is a pharmaceutical composition for administering an effective amount of a compound of Formula I in unit dosage form in the treatment methods mentioned above. 
     Finally, the present invention is directed to methods for production of a compound of Formula I. 
     DETAILED DESCRIPTION OF THE INVENTION 
     In the compounds of Formula I, the term &#34;lower alkyl&#34; means a straight or branched hydrocarbon radical having from one to six carbon atoms and includes, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, and the like. 
     The term &#34;cycloalkyl&#34; means a three- to seven-member saturated hydrocarbon ring and includes, for example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and the like. 
     The term &#34;cycloalkylalkyl&#39; means a cycloalkyl group as defined above attached to a lower alkyl group as defined above and includes, for example, cyclopropylmethyl, cyclohexylmethyl, and the like. 
     The term &#34;aryl&#34; means an aromatic radical which is a phenyl group or phenyl group substituted by one to four substituents selected from lower alkyl, lower alkoxy, lower thioalkoxy, halogen or trifluoromethyl such as, for example, benzyl, phenethyl, and the like. 
     The term &#34;heteroaryl&#34; means a heteroaromatic radical which is 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2-or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2- 4-, or 5-thiazolyl substituted by lower alkyl or halogen. 
     The term &#34;aryl lower alkyl&#34; means an aromatic radical, as defined above, attached to a lower alkyl group as defined above. 
     The term &#34;heteroaryl lower alkyl&#34; means a heteroaromatic radical, as defined above, attached to a lower alkyl group as defined above. 
     The term &#34;lower alkanoyl&#34; means a lower alkyl group as defined above attached to a carbonyl group which is then attached to the parent molecular residue. 
     The term &#34;cycloalkanoyl&#34; means a cycloalkyl ring as defined above attached to a carbonyl group which is then attached to the parent molecular residue and includes for example, cyclopropanoyl, cyclobutanoyl, cyclopentanoyl, cyclohexanoyl, cycloheptanoyl, and the like. 
     The term &#34;cycloalkylalkanoyl&#34; means a cycloalkyl ring as defined above attached to a lower alkanoyl group as defined above. 
     The term &#34;aryl lower alkanoyl&#34; means an aromatic radical, as defined above, attached to a lower alkanoyl group as defined above. 
     The term &#34;heteroaryl lower alkanoyl&#34; means a heteroaromatic radical, as defined above, attached to a lower alkanoyl group as defined above. 
     The term &#34;aroyl&#34; means an aromatic radical as defined above attached to a carbonyl group which is then attached to the parent molecular residue. 
     The term &#34;heteroaroyl&#34; means a heteroaromatic radical as defined above attached to a carbonyl group which is then attached to the parent molecular residue. 
     &#34;Lower alkoxy&#34; and &#34;thioalkoxy&#34; are O-alkyl or S-alkyl of from one to six carbon atoms as defined above for &#34;lower alkyl.&#34; 
     &#34;Halogen&#34; is fluorine, chlorine, bromine, or iodine. 
     &#34;Alkali metal&#34; is a metal in Group IA of the periodic table and includes, for example, lithium, sodium, potassium, and the like. 
     &#34;Alkaline-earth metal&#34; is a metal in Group IIA of the periodic table and includes, for example, calcium, barium, strontium, magnesium and the like. 
     &#34;Noble metal&#34; is platinum, palladium, rhodium, ruthenium, and the like. 
     Pharmaceutically acceptable acid addition salts of the compounds of Formula I include salts derived from nontoxic inorganic acids, such as hydrochloric, nitric, phosphoric, sulfuric, hydrobromic, hydriodic, phosphorous, and the like, as well as the salts derived from nontoxic organic acids, such as aliphatic mono- and dicarboxylic acids, phenyl-substituted alkanoic acids, hydroxy alkanoic acids, alkanedioic acids, aromatic acids, aliphatic and aromatic sulfonic acids, etc. Such salts thus include sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, nitrate, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, acetate, propionate, caprylate, isobutyrate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, mandelate, benzoate, chlorobenzoate, methylbenzoate, dinitrobenzoate, phthalate, benzenesulfonate, toluenesulfonate, phenylacetate, citrate, lactate, maleate, tartrate, methanesulfonate, and the like. Also contemplated are salts of amino acids such as arginate and the like and gluconate, galacturonate (see, for example, Berge, S. M., et al, &#34;Pharmaceutical Salts,&#34; Journal of Pharmaceutical Science, Vol. 66, pages 1-19 (1977)). 
     The acid addition salts of said basic compounds are prepared by contacting the free base form with a sufficient amount of the desired acid to produce the salt in the conventional manner. The free base form may be regenerated by contacting the salt form with a base and isolating the free base in the conventional manner. The free base forms differ from their respective salt forms somewhat in certain physical properties such as solubility in polar solvents, but otherwise the salts are equivalent to their respective free base for purposes of the present invention. 
     Certain of the compounds of the present invention can exist in unsolvated forms as well as solvated forms, including hydrated forms. In general, the solvated forms, including hydrated forms, are equivalent to unsolvated forms and are intended to be encompassed within the scope of the present invention. 
     The compounds of the present invention may exist as a mixture of cis and trans isomers or as the individual cis and trans isomers. The mixture of isomers as well as the individual isomers are intended to be encompassed within the scope of the present invention. 
     A preferred compound of Formula I is one wherein 
     R is --OR 3 , wherein R 3  is hydrogen or lower alkanoyl, ##STR14##  wherein R 4  is hydrogen, cycloalkyl, cycloalkylalkyl, lower alkanoyl, aroyl, aryl lower alkanoyl, or heteroaroyl and r 5  is hydrogen or lower alkyl or; ##STR15##  wherein one of R 4  or R 5  is hydrogen and the other is hydrogen, lower alkyl, cycloalkyl, cycloalkyalkyl, aryl, or lower alkanoyl; 
     m is zero; 
     R 1  is hydrogen, phenyl, phenyl substituted by para lower alkyl, para lower alkoxy, para lower thioalkoxy, or para halogen, 2-, 3-, or 4-pyridinyl, 2-, or 3-furanyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl; 
     n is zero or an integer from 1 to 3; and 
     R 2  is ##STR16## wherein R 7  is phenyl, phenyl substituted by para lower alkyl, para lower alkoxy, para lower thioalkoxy, or para halogen, 2-, 3-, or 4-pyridinyl, 2- or 3-furanyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl. 
     Another preferred embodiment is a compound of Formula I wherein 
     R is --OH, ##STR17##  wherein R 4  is hydrogen, cycloalkyl, cycloalkylalkyl, lower alkanoyl, aroyl or heteroaroyl and R 5  is hydrogen or lower alkyl; or 
     --NHOR 4 , wherein R 4  is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, or lower alkanoyl; 
     m is zero; 
     R 1  is hydrogen, phenyl, phenyl substituted by para lower alkyl or para halogen, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl; 
     n is zero or an integer from 1 to 2; and 
     R 2  is ##STR18## wherein R 7  is hydrogen, phenyl, phenyl substituted by para lower alkyl or para halogen, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl. 
     Particularly valuable are: 
     [2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol (mixture of cis/trans); 
     cis-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol; 
     trans-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol; 
     1-Phenyl-4-[2-4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans); 
     1-(2-Pyridinyl)-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethylcyclohexanol (mixture of cis/trans); 
     1-(4-Fluorophenyl)-4-[2-4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans); 
     cis-1-(4-Methoxyphenyl)-4-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol; 
     trans-1-(4-Methoxyphenyl)-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol; 
     4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thiazolyl)cyclohexanol (mixture of cis/trans); 
     1-(3-Pyridinyl)-4-[2-[4-(2-pyridinyl)-1-piperazinylethyl]cyclohexanol (mixture of cis/trans); 
     cis-1-(2-Pyridinyl)-4-[2-[3,6-dihydro-4-phenyl-1(2H)-pyridinyl]ethyl]cyclohexanol; 
     cis-1-(3-Pyridinyl)-4-[2-[3,6-dihydro-4-phenyl-1(2H)-pyridinyl]ethyl]cyclohexanol; 
     cis-4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]-1-(2-thienyl)cyclohexanol; 
     4-2-4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(3-thienyl)cyclohexanol (mixture of cis/trans); 
     trans-4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]- 1-(2-thienyl)cyclohexanol; 
     cis-4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1-(2-thienyl)cyclohexanol; 
     trans-1-(2-Pyridinyl)-4-[4-(2-pyrimidinyl)-1-piperazinyl]cyclohexanol; 
     cis-1-(2-Pyridinyl)-4-[4-(2-pyrimidinyl)-1-piperazinyl]cyclohexanol; 
     trans-1-(2-Pyridinyl)-4-[4-(2-pyridinyl)-1piperazinyl]cyclohexanol; 
     cis-1-(2-Pyridinyl)-4-4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; 
     trans-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; 
     cis-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol 
     4-[4-(2-Pyridinyl)-1-piperazinyl]-1-(2-thienyl)cyclohexanol (mixture of cis/trans); 
     4-[4-(2-Pyridinyl)-1-piperazinyl-1-(3-thienyl)cyclohexanol (mixture of cis/trans); 
     trans-1-(4-Chlorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; 
     cis-1-(4-Chlorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; 
     1-(4-Methoxyphenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol (mixture of cis/trans); 
     1-Phenyl-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol (mixture of cis/trans); 
     4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(2-pyridinyl)cyclohexanol (mixture of cis/trans); 
     trans-4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(3-pyridinyl)cyclohexanol; 
     cis-4-[3,6-Dihydro-4-phenyl-1(2H)-pyridinyl]-1(3-piperazinyl)cyclohexanol; 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-2-methoxybenzamide; 
     trans N-Methyl-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; 
     trans 4-Chloro-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-2-thiophenecarboxamide; 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-3-thiophenecarboxamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]benzamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-2-thiophenecarboxamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-3-thiophenecarboxamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-3-pyridinecarboxamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]cyclohexanecarboxamide; 
     trans 4-Methyl-N-[4-[4-(2-pyridinyl)-1-piperazinylcyclohexyl]benzamide; 
     trans N-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     cis N-[4-2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     trans 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     cis 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     cis 4-Chloro-N-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     trans 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethylcyclohexyl]benzamide; 
     trans N-[4-2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]acetamide; 
     trans 3,4-Dichloro-N-[4-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     trans N-[4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]benzamide; 
     cis 3,4-Dichloro-N-[4-[2-[4-(2-pyridinyl)-1piperazinyl]ethyl]cyclohexyl]benzamide; 
     trans 4-Chloro-N-[4-(3,6-dihydro-4-phenyl-1(2H)- pyridinyl)cyclohexyl]benzamide; 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-4-fluorobenzamide; 
     trans N-[4[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]-3-thiophenecarboxamide; 
     trans 4-Methoxy-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     cis-N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-3-thiophenecarboxamide; 
     cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-furancarboxamide; 
     cis 4-Methoxy-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; 
     cis N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)pyridinyl)ethyl]cyclohexyl]benzamide; 
     cis N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)pyridinyl)ethyl]cyclohexyl]-2-thiophenecarboxamide; 
     trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)pyridinyl)ethyl]cyclohexyl]-2-thiophenecarboxamide; 
     trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)pyridinyl)ethyl]cyclohexyl]benzamide; 
     trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-thiophenecarboxamide; and 
     cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-thiophenecarboxamide; or a pharmaceutically acceptable acid addition salt thereof. 
     The compounds of Formula I are valuable dopaminergic agents. The tests employed indicate that compounds of Formula I possess dopaminergic activity. Thus, the compounds of Formula I were tested for their ability to inhibit locomotor activity in mice according to the assay described by J. R. McLean, et al, Pharmacology, Biochemistry and Behavior, Volume 8, pages 97-99 (1978); for their ability to inhibit [ 3  ]-spiroperidol binding in a receptor assay described by D. Grigoriadis and P. Seeman, Journal of Neurochemistry, Volume 44, pages 1925-1935 (1985); and for their ability to inhibit dopamine synthesis in rats according to the protocol described by J. R. Walters and R. H. Roth, Naunyn-Schmiedeberg&#39;s Archives of Pharmacology, Volume 296, pages 5-14 (1976). The above test methods are incorporated herein by reference. The data in the table show the dopaminergic activity of representative compounds of Formula I. Additionally, the compounds of Formula I are ligands for the sigma opiate binding site. The data in the table show the inhibition of [ 3  H] DTG (ditoluoyl guanidine; a sigma ligand) binding by representative compounds of Formula I, according to the method of E. Weber, et al, Proceedings of the National Academy of Sciences, USA, Volume 83, pages 8784-8788 (1986). 
     
         __________________________________________________________________________Biological Activity of Compounds of Formula I                              Inhibition                                        Effects on                     Inhibition of                              of Locomotor                                        Brain Striatal                                                  Inhibition                     [.sup.3 H]-Spiroperidol                              Activity  Dopamine Synthesis                                                  of [.sup.3 H] DTGExample                   Binding  in Mice   in Rats at                                                  BindingNumber Compound            IC.sub.50 nM                              ED.sub.50 , mg/kg, IP                                        10 mg/kg, IP                                                  IC.sub.50__________________________________________________________________________                                                  nM 1    trans-1-(4-Chlorophenyl)-4-[4-(2-                     333      2.3 pyridinyl)-1-piperazinyl]cyclohexanol 1a   cis-1-(4-Chlorophenyl)-4-[4-(2-                     816      0.86 pyridinyl)-1-piperazinyl]cyclohexanol 3    cis-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]-                     262      1.3       67% inhibition                                                  6.0 ethyl]-1-(2-thienyl)cyclohexanol 4    trans-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]-                     341      1.1       47% inhibition                                                  5.0 ethyl]-1-(2-thienyl)cyclohexanol 5    1-Phenyl-4-[2-[4-(2-pyridinyl)-1-                     537      1.8       35% inhibition piperazinyl]ethyl]cyclohexanol (mixture of cis/trans) 6    1-(2-Pyridinyl)-4-[2-[4-(2-pyridinyl)-                     1047     0.34 1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans) 7    1-(4-Fluorophenyl)-4-[2-[4-(2-                     94% inhibition                              0.64      48% inhibition                                                  16.5 pyridinyl)-1-piperazinyl]ethyl]-                     at 10.sup.-5 M cyclohexanol (mixture of cis/trans) 8    cis-1-(4-Methoxyphenyl)-4-[2-[4-(2-                     169      0.9       88% inhibition pyridinyl)-1-piperazinyl]ethyl]- cyclohexanol 9    4-[2-[4-(2-Pyridinyl)-1-piperazinyl]-                     1550     1.0 ethyl]-1-(2-thiazolyl)cyclohexanol (mixture of cis/trans)10    1-(3-Pyridinyl)-4-[2-[4-(2-pyridinyl)-                     847      0.37 1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans)11    cis-1-(2-Pyridinyl)-4-[2-[3,6-dihydro-                     156      0.64                3.5 4-phenyl-1(2H)-pyridinyl]ethyl]cyclo- hexanol12    cis-1-(3-Pyridinyl)-4-[2-[3,6-dihydro-                     116      0.25      79% inhibition 4-phenyl-1(2H)-pyridinyl]ethyl]cyclo- hexanol13    cis-4-[2-(3,6-Dihydro-4-phenyl-1(2H)-                      51      2 pyridinyl)ethyl]-1-(2-thienyl)cyclo- hexanol14    4-[2-[4-(2-Pyridinyl)-1-piperazinyl]-                     312      0.48      37% inhibition                                                  4.5 ethyl]-1-(3-thienyl)cyclohexanol (mixture of cis/trans)15    trans-1-(4-Methoxyphenyl)-4-[2-[4-                     932      0.3       52% inhibition (2-pyridinyl)-1-piperazinyl]ethyl]- cyclohexanol16    trans-4-[[4-(2-Pyridinyl)-1-piperazinyl]-                              4.3 methyl]-1-(2-thienyl)cyclohexanol17    cis-4-[[4-(2-Pyridinyl)-1-piperazinyl]-                     3900     5.2 methyl]-1-(2-thienyl)cyclohexanol18    trans-1-(2-Pyridinyl)-4-[4-(2-                              &gt;30 pyrimidinyl)-1-piperazinyl]cyclohexanol19    cis-1-(2-Pyridinyl)-4-[4-(2-pyrimidinyl)-                              13.0 1-piperazinyl]cyclohexanol20    trans-1-(2-Pyridinyl)-4-[4-(2-pyridinyl)-                              &gt;30 1-piperazinyl]cyclohexanol21    cis-1-(2-Pyridinyl)-4-[4-(2-pyridinyl)-                     2785     2.3 1-piperazinyl]cyclohexanol22    trans-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-                     12500    30 1-piperazinyl]cyclohexanol23    cis-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-                     1155     1.6 1-piperazinyl]cyclohexanol24    4-[4-(2-Pyridinyl)-1-piperazinyl]-1-                              &gt;30 (2-thienyl)cyclohexanol (mixture of cis/trans)25    4-[4-(2-Pyridinyl)-1-piperazinyl]-1-                     2700     2.4 (3-thienyl)cyclohexanol (mixture of cis/trans)26    1-(4-Methoxyphenyl)-4-[4-(2-pyridinyl)-                     670      0.3 1-piperazinyl]cyclohexanol (mixture of cis/trans)27    1-Phenyl-4-[4-(2-pyridinyl)-1-                     1660     0.83 piperazinyl]cyclohexanol (mixture of cis/trans)28    4-(3,6-Dihydro-4-phenyl-1(2H)-                              1.8 pyridinyl)-1-(2-pyridinyl)cyclohexanol (mixture of cis/trans)29    trans-4-(3,6-Dihydro-4-phenyl-1(2H)-                              25.6 pyridinyl)-1-(3-pyridinyl)cyclohexanol30    cis-4-(3,6-Dihydro-4-phenyl-1(2H)-                     1250     1.3 pyridinyl)-1-(3-pyridinyl)cyclohexanol40    trans N-[4-[4-(2-Pyridinyl)-1-                     2800     0.36      65% inhibition piperazinyl]cyclohexyl]benzamide41    trans N-[4-[4-(2-Pyridinyl)-1-                     530      1.9 piperazinyl]cyclohexyl]-2-methoxy- benzamide42    trans N-Methyl-N-[4-[4-(2-pyridinyl)-1-                     4840     2.4       15% inhibition piperazinyl]cyclohexyl]-benzamide43    trans 4-Chloro-N-[4-[4-(2-pyridinyl)-1-                     7790     0.78 piperazinyl]cyclohexyl]benzamide44    trans N-[4-[4-(2-Pyridinyl)-1-                     2520     0.29 piperazinyl]cyclohexyl]-2- thiophenecarboxamide46    trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-                     360      0.16      95% inhibition pyridinyl)cyclohexyl]benzamide47    trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-                     300      0.23      74% inhibition pyridinyl)cyclohexyl]-2-thiophene- carboxamide48    trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-                      90      0.27      88% inhibition pyridinyl)cyclohexyl]-3-thiophenecarbox- amide49    trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-                     600      2.4       72% inhibition pyridinyl)-cyclohexyl]-3-pyridine- carboxamide50    trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-                     1600     1.1 pyridinyl)cyclohexyl]cyclohexane- carboxamide52    trans N-[4-[2-[4-(2-Pyridinyl)-1-                     440      0.16      87% inhibition piperazinyl]ethyl]cyclohexyl]benzamide53    cis N-[4-[2-[4-(2-Pyridinyl)-1-                     3280     4.5       36% inhibition piperazinyl]ethyl]cyclohexyl]benzamide54    trans 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-                     290      0.11       0% inhibition 1-piperazinyl]ethyl]cyclohexyl]benzamide55    cis 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-                     830 1-piperazinyl]ethyl]cyclohexyl]- benzamide56    cis 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-                     1620     6.30 1-piperazinyl]ethyl]cyclohexyl]- benzamide57    trans 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-                     620      0.51 1-piperazinyl]ethyl]cyclohexyl]- benzamide58    trans N-[4-[2-[4-(2-Pyridinyl)-1-                              0.03      87% inhibition piperazinyl]ethyl]cyclohexyl]acetamide59    trans 3,4-Dichloro-N-[4-[2-[4-(2-                              14.4       7% inhibition pyridinyl)-1-piperazinyl]ethyl]- cyclohexyl]benzamide60    trans N-[4-[[4-(2-Pyridinyl)-1-                              1.0       36% inhibition piperazinyl]methyl]cyclohexyl]- benzamide69    cis N-[4-[2-(3,6-Dihydro-4-phenyl-                              2.1 1(2H)-pyridinyl)ethyl]cyclohexyl]- benzamide70    cis N-[4-[2-(3,6-Dihydro-4-phenyl-                     280 1(2H)-pyridinyl)ethyl]cyclohexyl]-2- thiophenecarboxamide71    trans N-[4-[2-(3,6-Dihydro-4-phenyl-                     210      0.21      79% inhibition 1(2H)-pyridinyl)ethyl]cyclohexyl]-2- thiophenecarboxamide72    trans N-[4-[2-(3,6-Dihydro-4-phenyl-                     100      0.27      74% inhibition 1(2H)-pyridinyl)ethyl]cyclohexyl]- benzamide73    trans N-[4-[2-[4-(2-Pyridinyl)-1-                     220      0.09      86% inhibition piperazinyl]ethyl]cyclohexyl]-2- thiophenecarboxamide74    cis N-[4-[2-[4-(2-Pyridinyl)-1-                     1460     1.6       51% inhibition piperazinyl]ethyl]cyclohexyl]-2- thiophenecarboxamide__________________________________________________________________________ 
    
     A compound of Formula Ia ##STR19## wherein R is --OH, ##STR20##  wherein R 4  is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aryl lower alkyl, lower alkanoyl, cycloalkanoyl, cycloalkylalkanoyl, aryl lower alkanoyl, or aroyl, ##STR21## wherein R 4  is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aryl lower alkyl, lower alkanoyl, aryl lower alkanoyl, or aroyl; 
     m is zero or an integer from 1 to 2; 
     R is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; 
     n is zero or an integer from 1 to 4; 
     R 2  is ##STR22##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula II ##STR23##  wherein A is O, N--R 4  wherein R 4  is as defined above, or N--OR 4  wherein R 4  is as defined above, 
     and R 2  and n are as defined above with a compound of Formula III ##STR24##  wherein M is magnesium-Hal, wherein Hal is halogen or M is lithium and R 1  and m are as defined above, in the presence of a solvent such as, for example, tetrahydrofuran, diethyl ether, and the like at about --78° C. to about the reflux temperature of the solvent for about 0.5 to about 24 hours to give a compound of Formula Ia. 
     A compound of Formula Ib ##STR25## wherein R a  is --OR 3 , wherein R 3  is lower alkyl, cycloalkyl, cycloalkylalkyl, or aryl lower alkyl; 
     m is zero or an integer from 1 to 2; 
     R 1  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; 
     n is zero or an integer from 1 to 4; 
     R 2  is ##STR26##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula Ic ##STR27##  wherein R 1 , m, n, and R 2  are as defined above with a compound of Formula IV 
     
         R.sup.3 -Hal                                               IV 
    
      wherein Hal is halogen and R 3  is as defined above in the presence of a base such as an organic base, for example, triethylamine, pyridine and the like, an inorganic base, for example, an alkali metal or alkaline earth metal hydroxide or carbonate, alkali metal hydride and the like and a solvent such as, for example, dichloromethane, and the like at about -78° C. to about the reflux temperature of the solvent for about 0.5 to about 24 hours to give a compound of Formula Ib. 
     A compound of Formula Id ##STR28## wherein R b  is --OR 3 .spsp.a, wherein R 3 .spsp.a is lower alkanoyl, aroyl, or aryl lower alkanoyl; 
     m is zero or an integer from 1 to 2; 
     R 1  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; 
     n is zero or an integer from 1 to 4; 
     R 2  is ##STR29##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula Ic with a compound of Formula V 
     
         R.sup.3.spsp.a -Hal                                        V 
    
      wherein Hal is halogen and R 3 .spsp.a is as defined above using the methodology used to prepare a compound of Formula Ib from a compound of Formula Ic and a compound of Formula IV to give a compound of Formula Id. 
     A compound of Formula Ie ##STR30## wherein R c  is ##STR31## wherein R 4  and R 5  are each independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aryl lower alkyl, heteroaryl lower alkyl, lower alkanoyl, aryl lower alkanoyl, heteroaryl lower alkanoyl, aroyl, heteroaroyl, or R 4  and R 5  are taken together with the nitrogen atom to which they are attached to form a ring denoted by   wherein p is zero or an integer from 1 to 4 and R 6  is hydrogen, lower alkyl, cycloalkyl, or cycloalkylalkyl, ##STR32## wherein X is oxygen or sulfur or ##STR33## wherein R 6  is as defined above, or ##STR34##  wherein R 4  and R 5  are each independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aryl lower alkyl, lower alkanoyl, aryl lower alkanoyl, aroyl, or R 4  and R 5  are taken together with the oxygen and nitrogen atoms to which they are attached to form a ring denoted by ##STR35##  wherein q is an integer from 2 to 3 and R 6  is as defined above; m is zero or an integer from 1 to 2; 
     R 1  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; 
     n is zero or an integer from 1 to 4; 
     R 2  is ##STR36##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula VI ##STR37##  wherein R c , R 2 , and n are as defined above with a compound of Formula III wherein M, R 1 , and m are as defined above in the presence of a solvent such as, for example, tetrahydrofuran and the like at about 0° C. for about 0.5 to about 24 hours to give a compound of Formula Ie. 
     A compound of Formula If ##STR38## wherein n is zero or an integer from 1 to 4; 
     R 2  is ##STR39##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula IIb ##STR40##  wherein R 2  and n are as defined above with a metal hydride such as, for example, lithium aluminum hydride and the like and a solvent such as, for example, tetrahydrofuran and the like or alternatively treating with hydrogen in the presence of a catalyst such as a noble metal, for example, platinum, palladium, rhodium, ruthenium, derivatives thereof, and the like to give about 1:1 mixture of the cis and trans isomers of a compound of Formula If which if desired may be separated into the individual cis or trans isomers by conventional methodology such as, for example, by fractional crystallization, chromatography and the like. 
     A compound of Formula Ig ##STR41## wherein R 4 .spsp. a is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl lower alkyl, heteroaryl lower alkyl, aryl or heteroaryl; 
     n is zero or an integer from one to four; 
     R 2  is ##STR42##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula If with a compound of Formula XIX ##STR43##  wherein L is halogen or a leaving group such as, for example, CH 3  SO 2  O-, para-CH 3  C 6  H 4  SO 2  O-, and the like and R 4 .spsp.a is as defined above in the presence of a base such as, for example, triethylamine, pyridine and the like and a solvent such as, for example, dichloromethane and the like to give a compound of Formula Ig. 
     A compound of Formula Ih ##STR44## wherein R 4 .spsp.a is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl lower alkyl, heteroaryl lower alkyl, aryl or heteroaryl; 
     R 5 .spsp.a is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aryl lower alkyl or heteroaryl lower alkyl; n is zero or an integer from one to four; 
     R 2  is ##STR45## wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4- pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5- pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3- furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula Ig with a compound of Formula XX 
     
         R.sup.5.spsp.a -Hal                                        XX 
    
      wherein Hal is halogen and R 5 .spsp.a is as defined above in the presence of a metal hydride such as, for example, sodium hydride and the like and a solvent such as, for example, tetrahydrofuran, dimethylformamide and the like to give a compound of Formula Ih. 
     A compound of Formula Ii ##STR46## R 4 .spsp.a is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl lower alkyl, heteroaryl lower alkyl, aryl, or heteroaryl; 
     n is zero or an integer from 1 to 4; 
     R 2  is ##STR47##  wherein R 7  is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula Ig with a compound of Formula XIX using the methodology used to prepare a compound of Formula If to give a compound of Formula Ii. 
     A compound for Formula Ij ##STR48## wherein R 5 .spsp.a is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aryl lower alkyl or heteroaryl lower alkyl; n is zero or an integer from one to four; 
     R 2  is ##STR49##  wherein R 7  is aryl, 2-, 3-, or 4- pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof may be prepared by reacting a compound of Formula IIc ##STR50## wherein A b  is N-R 5 .spsp.a, and R 5 .spsp.a, n and R 2  are defined above in the presence of a metal hydride such as, for example, lithium aluminum hydride, sodium borohydride and the like to give a compound of Formula Ij. 
     Alternatively, a compound of Formula Ih may be prepared from a compound of Formula Ij by reacting with a compound of Formula XIX using the methodology used to prepare a compound of Formula Ig. 
     A compound of Formula VI is prepared from a compound of Formula IIa ##STR51## wherein R 2  and n are as defined above and a compound of Formula VII 
     
         R.sup.c H                                                  VII 
    
     wherein R c  is as defined above in the presence of an alkali metal cyanide such as, for example, potassium cyanide and the like and about an equivalent of an acid such as an organic acid, for example, acetic acid and the like, an inorganic acid, for example, hydrochloric acid and the like, in the presence of a solvent such as, for example, methanol, ethanol and the like at about room temperature to give a compound of Formula VI. 
     A compound of Formula IIa is prepared from a compound of Formula VIII ##STR52## wherein R 8  and R 9  are alkyl of one to six carbon atoms or R 8  and R 9  together are ##STR53##  --CH 2  CH 2  -- or --CH 2  CH 2  CH 2  -- and R 2  and n are as defined above by treatment with an acid such as, for example, a 10% aqueous solution of hydrochloric acid in the presence of a solvent such as, for example, acetone and the like to give a compound of Formula IIa. 
     A compound of Formula VIIIa ##STR54## wherein n is zero and R 2 , R 8 , and R 9  are as defined above is prepared from a compound of Formula IX ##STR55## wherein R 2 , R 8 , and R 9  are as defined above by treatment with a reducing agent such as, for example, sodium cyanoborohydride and the like in a solvent such as, for example, methanol and the like in the presence of an acid such as, for example, hydrochloric acid and the like or, alternatively, reduction is carried out with hydrogen in the presence of a catalyst such as, for example, palladium on carbon in the presence of a solvent such as, for example, methanol and the like to give a compound of Formula VIIIa. 
     A compound of Formula IX is prepared from a compound of Formula X ##STR56## wherein R 8  and R 9  are as defined above in the presence of a catalytic amount of an acid such as, for example, para-toluenesulfonic acid and the like in the presence of a solvent suited for the azeotropic removal of water such as, for example, toluene and the like to give a compound of Formula IX. 
     A compound of Formula VIIIb wherein n is an integer from 1 to 4 and R 2 , R 8 , and R 9  are as defined above is prepared from a compound of Formula XI ##STR57## wherein n is an integer from 1 to 4 and R 2 , R 8 , and R 9  are as defined above by treatment with a reducing agent such as, for example, diborane, aluminum hydride and the like in a solvent such as, for example, tetrahydrofuran and the like to give a compound of Formula VIIIb. 
     A compound of Formula XI is prepared from a compound of Formula XII ##STR58## wherein n is an integer from 1 to 4 and R 8  and R 9  are as defined above and a compound of Formula XI. In order to obtain the reaction of these two compounds, a compound of Formula XII must be activated in the presence of a chloroformate such as, for example, isobutyl chloroformate and a base such as, for example, triethylamine, or alternatively, a coupling reagent such as, for example, dicyclohexylcarbodiimide, carbonyldiimidazole and the like in the presence of a solvent such as, for example, dichloromethane and the like to give a compound of Formula XI. 
     A compound of Formula XII is prepared from a compound of Formula XIII ##STR59## wherein n is an integer from 1 to 4, R 10  is lower alkyl and R 8  and R 9  are as defined above, by hydrolysis with a base such as, for example, potassium hydroxide and the like in an alcohol such as, for example, ethanol and the like to give a compound of Formula XII. 
     A compound of Formula XIII is prepared from a compound of Formula XIV ##STR60## wherein n is an integer from 1 to 4 and R 10  is as defined above using conventional procedures known in the art. 
     Alternatively, a compound of Formula VIIIb is prepared from a compound of Formula XV ##STR61## wherein n is an integer from 1 to 4, L is halogen, CH 3  SO 2  O--, para--CH 3  C 6  H 4  SO 2  O--and the like, and R 8  and R 9  are as defined above and a compound of Formula XVI 
     
         R.sup.2 H                                                  XVI 
    
     wherein R 2  is as defined above in the presence of a base such as, for example, sodium bicarbonate and the like and a solvent such as, for example, dimethylformamide and the like to give a compound of Formula VIIIb. 
     A compound of Formula XV is prepared from a compound of Formula XVII ##STR62## wherein n is an integer from 1 to 4 and R 8  and R 9  are as defined above by treatment with thionyl chloride, thionyl bromide and the like in the presence of a solvent such as, for example, chloroform and the like or, alternatively, treatment with methanesulfonyl chloride, para-toluenesulfonyl chloride and the like in the presence of a base such as, for example, pyridine and the like to give a compound of Formula XV. 
     A compound of Formula XVII is prepared from a compound of Formula XIV wherein n is an integer from 1 to 4 and R 8 , R 9 , and R 10  are as defined above by treatment with a complex metal hydride such as, for example, diborane, lithium aluminum hydride and the like in the presence of a solvent such as, for example, tetrahydrofuran and the like to give a compound of Formula XVII. 
     A compound of Formula IId ##STR63## wherein A a  is N--R 4  wherein R 4  is as defined above, or 
     N--OR 4  wherein R 4  is as defined above and R 2  and n are as defined above is prepared from a compound of Formula IIa and a compound of Formula XVIII 
     
         A.sup.a H                                                  XVIII 
    
     wherein A a  is ##STR64## wherein R 4  is as defined above, or ##STR65## wherein R 4  is as defined above, in the presence of an acid such as, for example, para-toluenesulfonic acid to give a compound of Formula IId. 
     Compounds of Formula III, Formula IV, Formula V, Formula VII, Formula X, Formula XI, Formula XIV, Formula XVIII, Formula XIX and Formula XX are either known or capable of being prepared by methods known in the art. 
     A compound of Formula I may exist as a mixture of cis or trans isomers or as the separate cis or trans isomer. Accordingly, as another aspect of the present invention, a mixture of cis and trans isomers of Formula I may be separated into the individual cis or trans isomer by conventional methodology such as, for example, by fractional crystallization, chromatography and the like. 
     The compounds of the present invention can be prepared and administered in a wide variety of oral and parenteral dosage forms. It will be obvious to those skilled in the art that the following dosage forms may comprise as the active component, either a compound of Formula I or a corresponding pharmaceutically acceptable salt of a compound of Formula I. 
     For preparing pharmaceutical compositions from the compounds of the present invention, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier can be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. 
     In powders, the carrier is a finely divided solid which is in a mixture with the finely divided active component. 
     In tablets, the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. 
     The powders and tablets preferably contain from five or ten to about seventy percent of the active compound. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term &#34;preparation&#34; is intended to include the formulation of the active compound with encapsulating material as a carrier providing a capsule in which the active component, with or without other carriers, is surrounded by a carrier, which is thus in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid dosage forms suitable for oral administration. 
     For preparing suppositories, a low melting wax, such as a mixture of fatty acid glycerides or cocoa butter, is first melted and the active component is dispersed homogeneously therein, as by stirring. The molten homogenous mixture is then poured into convenient sized molds, allowed to cool, and thereby to solidify. 
     Liquid form preparations include solutions, suspensions, and emulsions, for example, water or water propylene glycol solutions. For parenteral injection liquid preparations can be formulated in solution in aqueous polyethylene glycol solution. 
     Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing and thickening agents as desired. 
     Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well-known suspending agents. 
     Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for oral administration. Such liquid forms include solutions, suspensions, and emulsions. These preparations may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. 
     The pharmaceutical preparation is preferably in unit dosage form. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. 
     The quantity of active component in a unit dose preparation may be varied or adjusted from 1 mg to 1000 mg preferably 10 mg to 100 mg according to the particular application and the potency of the active component. The composition can, if desired, also contain other compatible therapeutic agents. 
     In therapeutic use as antipsychotic agents, the compounds utilized in the pharmaceutical method of this invention are administered at the initial dosage of about 1 mg to about 50 mg per kilogram daily. A daily dose range of about 5 mg to about 25 mg per kilogram is preferred. The dosages, however, may be varied depending upon the requirements of the patient, the severity of the condition being treated, and the compound being employed. Determination of the proper dosage for a particular situation is within the skill of the art. Generally, treatment is initiated with smaller dosages which are less than the optimum dose of the compound. Thereafter, the dosage is increased by small increments until the optimum effect under the circumstances is reached. For convenience, the total daily dosage may be divided and administered in portions during the day if desired. 
    
    
     The following nonlimiting examples illustrate the inventors&#39; preferred methods for preparing the compounds of the invention. 
     EXAMPLE 1 AND EXAMPLE 1a 
     cis- and trans-1-(4-Chlorophenyl)-4-[4-(2-pyridinyl)-1piperazinyl]cyclohexanol. 
     A solution of 5.74 g of 1-bromo-4-chlorobenzene in 100 mL anhydrous tetrahydrofuran is cooled to -78° C. under a nitrogen atmosphere. n-Butyllithium (18.75 mL of a 1.6M hexane solution) is added dropwise via syringe. The resulting suspension is stirred at -78° C. for 1 hour. To this solution is added a solution of 5.19 g of 4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanone (Example A) in 175 mL of tetrahydrofuran from an addition funnel. The addition of the ketone takes about 15 minutes. The mixture is allowed to warm to room temperature and quenched with 50 mL of saturated ammonium chloride solution. The tetrahydrofuran is evaporated under vacuum and the residue is partitioned into water/dichloromethane. The organic phase is separated, dried over magnesium sulfate, and evaporated in vacuo. The residue is chromatographed on silica gel using 3% methanol:97% dichloromethane as eluant. The less polar isomer in this solvent system is characterized as trans-1-(4-chlorophenyl)-4-[4 (2-pyridinyl) -1-piperazinyl]cyclohexanol containing 0.15 molecules of chloroform; mp 224-225° C (Example 1) and the more polar component is identified as cis-1(4-chlorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; mp 183-185° C. (Example 1a). 
     In a process analogous to Example 1 and Example 1a using appropriate starting materials the corresponding compounds of Formula I (Examples 2 to 30) are prepared as follows: 
     EXAMPLE 2 
     4-[2-4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol (mixture of cis/trans), containing 0.33 molecules of chloroform; mp 124-140° C. 
     EXAMPLE 3 
     cis-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol, hemihydrate; mp 151-154° C. 
     EXAMPLE 4 
     trans-4-2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thienyl)cyclohexanol; mp 108-109° C. 
     EXAMPLE 5 
     1-Phenyl-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans), containing 0.1 molecules of water; mp 158-163° C. 
     EXAMPLE 6 
     1-(2-Pyridinyl)-4-2-4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans), containing 0.25 molecules of water; mp 100-105° C. 
     EXAMPLE 7 
     1-(4-Fluorophenyl)-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans); mp 172-177° C. 
     EXAMPLE 8 
     cis-1-(4-Methoxyphenyl)-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol, containing 0.2 molecules of water; mp 142-144° C. 
     EXAMPLE 9 
     4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(2-thiazolyl)cyclohexanol (mixture of cis/trans), containing 0.75 molecules of chloroform; mp 65-80° C. 
     EXAMPLE 10 
     1-(3-Pyridinyl)-4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexanol (mixture of cis/trans), containing 0.2 molecules of water; mp 128-148° C. 
     EXAMPLE 11 
     cis-1-(2-Pyridinyl)-4-[2-[3,6-dihydro-4-phenyl-(2H)-pyridinyl]ethyl]cyclohexanol; mp 153-156° C. 
     EXAMPLE 12 
     cis-1-(3-Pyridinyl)-4-[2-[3,6-dihydro-4-phenyl-(2H)-pyridinyl]ethyl]cyclohexanol; mp 160-163° C. 
     EXAMPLE 13 
     cis-4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-ethyl]-1-(2-thienyl)cyclohexanol, containing 0.1 molecules of water; mp 164-170° C. 
     EXAMPLE 14 
     4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]-1-(3)thienyl)cyclohexanol (mixture of cis/trans), containing 0.2 molecules of water; mp 115-129° C. 
     EXAMPLE 15 
     trans-1-(4-Methoxyphenyl)-4-[2-[4-(2-pyridinyl)-1piperazinyl]ethyl]cyclohexanol, containing 0.2 molecules of water; mp 127-131° C. 
     EXAMPLE 16 
     trans-4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1-(2-thienyl)cyclohexanol; mp 50-52° C. 
     EXAMPLE 17 
     cis-4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1-2-thienyl)cyclohexanol, trihydrochloride, containing 2.5 molecules of water; mp 114-117° C. 
     EXAMPLE 18 
     trans-1-(2-Pyridinyl)-4-[4-(2-pyrimidinyl)-1-piperazinyl]cyclohexanol; mp 240-242° C. 
     EXAMPLE 19 
     cis-1-(2-Pyridinyl)-4-[4-(2-pyrimidinyl)-1-piperazinyl]cyclohexanol, trihydrochloride, containing 3.5 molecules of water; mp 138-140° C. 
     EXAMPLE 20 
     trans-1-(2-Pyridinyl)-4-4-(2-pyridinyl)-1-piperazinyl]cyclohexanol, containing 0.25 molecules of water; mp 86-93° C. 
     EXAMPLE 21 
     cis-1-(2-Pyridinyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-cyclohexanol, containing 0.4 molecules of water; mp 130-134° C. 
     EXAMPLE 22 
     trans-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol; mp 153-158° C. 
     EXAMPLE 23 
     cis-1-(3-Pyridinyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol, hemihydrate; mp 175-179° C. 
     EXAMPLE 24 
     4-[4-(2-Pyridinyl)-1-piperazinyl]-1-(2-thienyl)cyclohexanol (mixture of cis/trans); mp 130-135° C. 
     EXAMPLE 25 
     4-[4-(2-Pyridinyl)-1-piperazinyl]-1-(3-thienyl)cyclohexanol (mixture of cis/trans); mp 140-155° C. 
     EXAMPLE 26 
     1-(4-Methoxyphenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexanol (mixture of cis/trans); mp 154-157° C. 
     EXAMPLE 27 
     1-Phenyl-4-[4-(2-pyridinyl)-1-piperazinylcyclohexanol (mixture of cis/trans), containing 0.25 molecules of water; mp 164-172° C. 
     EXAMPLE 28 
     4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(2-pyridinyl)cyclohexanol (mixture of cis/trans); mp 157-159° C. 
     EXAMPLE 29 
     trans-4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(3-pyridinyl)cyclohexanol; mp 124-125° C. 
     EXAMPLE 30 
     cis-4-[3,6-Dihydro-4-phenyl-1(2H)-pyridinyl]-1-(3-pyridinyl)cyclohexanol; mp 199-200° C. 
     EXAMPLE 31 AND 31a 
     (cis) and (trans)-4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexylamine 
     A suspension of 15.0 g of 4-[4-(2-pyridinyl)-1piperazinyl]cyclohexanone oxime (Example B) in 300 mL of dry tetrahydrofuran is cooled in an ice bath. To this suspension, 5.7 g of lithium aluminum hydride is added in small portions over a period of 30 minutes. The reaction mixture is heated at reflux for 2 hours. The flask is cooled in an ice bath and the reaction is quenched by careful addition of 6 mL of water, followed by 6 mL of 15% sodium hydroxide solution in water, and finally 12 mL of water. The salts are filtered through celite and washed repeatedly with dichloromethane. The pooled filtrates are dried over magnesium sulfate and evaporated in vacuo to leave 15 g of a semisolid residue that consists of about equal amounts of cis- and trans-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexylamine. The isomers are separated by medium pressure liquid chromatography (MPLC):cis-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexylamine, mp 120-125° C. (Example 31). 
     trans-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexylamine, mp&gt;250° C. (Example 31a). 
     In a process analogous to Example 31 and Example 31a using appropriate starting materials the corresponding compound of Formula I (Examples 32 to 38) are prepared as follows: 
     EXAMPLE 32 
     cis-4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl amine, mp 97.7-98.7° C. 
     EXAMPLE 33 
     trans-4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl) cyclohexylamine; mp 105.6-106.5° C. 
     EXAMPLE 34 
     cis- and trans-4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexylamine 
     EXAMPLE 35 
     cis-4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexylamine; mp 78-79° C. 
     EXAMPLE 36 
     trans-4-2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexylamine; mp 82-84° C. 
     EXAMPLE 37 
     cis- and trans-4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexylamine. 
     EXAMPLE 38 
     cis- and trans-4-[2-[3,6-Dihydro-4-(2-pyridinyl)-(2H)-pyridinyl]ethyl]cyclohexylamine. 
     EXAMPLE 39 
     trans-N-4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]benzamide 
     To a solution of 5.8 g trans-4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexylamine (Example 31a) in 100 mL of dichloromethane is added 4 mL of triethylamine and 2.84 mL of benzoyl chloride. The reaction mixture is refluxed under nitrogen for 1 hour. Saturated sodium bicarbonate solution is added. Some of the product comes out of solution at this point and is isolated by filtration. The organic layer is dried and evaporated to give 5.2 g of trans-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; mp 241-244° C. 
     In a process analogous to Example 39 using appropriate starting materials, the corresponding compounds of Formula I are prepared. In certain examples a mixture of cis and trans isomers are used as starting material and the corresponding cis and trans isomers of Formula I can be separated by MPLC eluting with 3% methanol in dichloromethane or by fractional crystallization. Thus, Example 40 to 74 are prepared as follows: 
     EXAMPLE 40 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-benzamide; mp 241-244° C. 
     EXAMPLE 41 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]-cyclohexyl]-2-methoxybenzamide; mp 128-133° C. 
     EXAMPLE 42 
     trans N-Methyl-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; mp 176-179° C. 
     EXAMPLE 43 
     trans 4-Chloro-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide; mp 281-284° C. 
     EXAMPLE 44 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-2-thiophenecarboxamide; mp 255-258° C. 
     EXAMPLE 45 
     trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-3-thiophenecarboxamide; mp 250-256° C. 
     EXAMPLE 46 
     N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-cyclohexyl]benzamide; mp 238-240° C. 
     EXAMPLE 47 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-2-thiophenecarboxamide; mp 221-222° C. 
     EXAMPLE 48 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-Pyridinyl)cyclohexyl]-3-thiophenecarboxamide; mp 236.5-237.8° C. 
     EXAMPLE 49 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-3-pyridinecarboxamide; mp 230-231° C. 
     EXAMPLE 50 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]cyclohexanecarboxamide; mp 220-221° C. 
     EXAMPLE 51 
     trans 4-Methyl-N-4-[4-(2-pyridinyl-1-piperazinyl]cyclohexyl]benzamide; mp 240-242° C. 
     EXAMPLE 52 
     trans N-[4-[2-[4-(2-Pyridinyl-1-piperazinyl ethyl]cyclohexyl]benzamide; mp 206-210° C. 
     EXAMPLE 53 
     cis N-[4-[2-[4-(2-Pyridinyl-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 150-154° C. 
     EXAMPLE 54 
     trans 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 220-223° C. 
     EXAMPLE 55 
     cis 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 153-155° C. 
     EXAMPLE 56 
     cis 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl ethyl]cyclohexyl]benzamide; mp 149-151° C. 
     EXAMPLE 57 
     trans 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 228-231° C. 
     EXAMPLE 58 
     trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]acetamide; mp 188-190° C. 
     EXAMPLE 59 
     trans 3,4-Dichloro-N-[4-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 219-221° C. 
     EXAMPLE 60 
     trans N-[4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]benzamide; mp 206-208° C. 
     EXAMPLE 61 
     cis 3,4-Dichloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 151-153° C. 
     EXAMPLE 62 
     trans 4-Chloro-N-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]benzamide; mp 260-261° C. 
     EXAMPLE 63 
     trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl) cyclohexyl]-4-fluorobenzamide; mp 235-236° C. 
     EXAMPLE 64 
     trans N-[4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]-3 thiophenecarboxamide; mp 201-203° C. 
     EXAMPLE 65 
     trans 4-Methoxy-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 215-217° C. 
     EXAMPLE 66 
     cis-N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-3-thiophenecarboxamide; mp 188-200° C. 
     EXAMPLE 67 
     cis-N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-furancarboxamide; mp 140-143° C. 
     EXAMPLE 68 
     cis-4-Methoxy-N-4-[2-4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide; mp 125-130° C. 
     EXAMPLE 69 
     cis N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]benzamide; mp 130-133° C. 
     EXAMPLE 70 
     cis N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]-2-thiophenecarboxamide; mp 122-124° C. 
     EXAMPLE 71 
     trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl-2-thiophenecarboxamide; mp 211-215° C. 
     EXAMPLE 72 
     trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]benzamide; mp 219-224° C. 
     EXAMPLE 73 
     trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl cyclohexyl]-2-thiophenecarboxamide; mp 207-208° C. 
     EXAMPLE 74 
     cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-thiophenecarboxamide; mp 187-189° C. 
     PREPARATION OF STARTING MATERIALS 
     EXAMPLE A 
     4-4-(2-Pyridinyl)-1-piperazinyl]cyclohexanone. 
     A solution of 1,4-cyclohexanedione monoethyleneketal (50.0 g), 1-(2-pyridyl)piperazine (52.16 g), and p-toluenesulfonic acid (0.5 g) in 500 ml of toluene is refluxed with a Dean-Stark trap until the theoretical amount of water is collected (about four hours). The solvent is evaporated in vacuo and the residue is dissolved in 750 mL of methanol. This solution is cooled in an ice bath and sodium cyanoborohydride (30.1 g) is added in small portions over a 2-minute period. The resulting suspension is stirred mechanically and over the next 30 minutes enough concentrated hydrochloric acid solution is added dropwise to the reaction mixture to maintain a pH of about 4. The solvent is removed in vacuo to leave a semisolid residue which is dissolved in 300 mL of a 10% solution of hydrochloric acid in a well ventilated fume hood. This solution is diluted with an equal volume of acetone and refluxed for 2 hours. The volatile components of the mixture are removed in vacuo and the residue is cooled in an ice bath and made basic with concentrated ammonium hydroxide. The white solid which forms is recrystallized from ethyl acetane-heptane to give 52.4 g of the title compound; mp 142-144° C. 
     EXAMPLE B 
     4-4-(2-Pyridinyl)-1-piperazinylcyclohexanone oxime. 
     A solution of 45.0 g of 4-[4-(2-pyridinyl)-1piperazinyl]cyclohexanone (Example A) in 350 mL absolute ethanol is treated with 13.55 g of hydroxylamine hydrochloride and 19.7 g of triethylamine. The solution is refluxed for 16 hours. After cooling the mixture to room temperature, a white solid is filtered and washed several times with ethyl acetate. This solid is dried in vacuo and identified as the title compound; mp 186-189° C. (37.8 g). 
     In a process analogous to Example B using appropriate starting materials the corresponding oximes (Examples C to G) are prepared as follows: 
     EXAMPLE C 
     4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexanone oxime; mp 185-186° C. 
     EXAMPLE D 
     4-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclo hexanone oxime. 
     EXAMPLE E 
     4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclo hexanone oxime; mp 165-175° C. 
     EXAMPLE F 
     4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexanone oxime; mp 165-173° C. 
     EXAMPLE G 
     4-[2-[3,6-Dihydro-4-(2-pyridinyl)-1(2H)-pyridinyl]ethyl]cyclohexanone oxime; mp 172-179° C.

Technology Classification (CPC): 2