Patent Abstract:
A method of producing mechanically stable effervescent tablets with a high dissolving velocity and an according effervescent tablet are described. The effervescent tablets consist of at least one active substance or of a combination of active substances, of at least one binder, of possibly carriers as sweeteners, flavors, colorings, scents, softeners, bleaches, and of sherbets. In producing, propylglycol or glycerin is used as a binder for the effervescent tablets, and the active substances or the combination of active substances and possibly carriers are mixed with the binder. Afterwards, the sherbets are added to this mixture in an air-conditioned room. Then, the mixture including the sherbets is formed into tablets.

Full Description:
FIELD OF THE INVENTION 
     The invention relates to a method of producing effervescent tablets which consist of at least one active substance or a combination of active substances, of at least one binder, possibly of carriers as sweeteners, flavours, colourings, scents, softeners and bleaches, and of sherbets, wherein the active substance or the combination of active substances and possibly the carriers are mixed with the binder, wherein the sherbets are added to this mixture in an air-conditioned room, and wherein the mixture including the sherbets is formed into tablets. The invention also relates to an effervescent tablet which consists of at least one active substance or a combination of active substances, of at least one binder, possibly of carriers as sweeteners, flavours, colourings, scents, softeners and bleaches, and of sherbets. 
     PRIOR ART 
     To produce effervescent tablets it is known to form granules as a pre-step for the effervescent tablet. Such granules are, however, connected with difficulties since the sherbets of a effervescent tablet are extremely sensitive to humidity and for example adding water to the sherbets always causes a setting free of the carbon dioxide bound in the sherbets. 
     Besides the methods based on granulating the used substances also methods to produce effervescent tablets are known by which the substances are directly formed into tablets. Such a method is for example described in the European Patent Application 0 219 337. According to this method powdery dextrose or sucrose is used as a binder for the effervescent tablets. In comparative examples of the European Patent Application this binder is compared with different sugar substitutes as a binder. When using dextrose and/or sucrose as a binder the amount of binder is 10 to 40% per weight of the whole effervescent tablet. 
     OBJECT OF THE INVENTION 
     It is the object of the invention to provide a simple method of producing stable effervescent tablets having a short dissolving time wherein any active substance or any combination of substances can be used and wherein only a small amount of binder compared to the whole weight of the effervescent tablet is needed. Further, a effervescent tablet is to be provided that can be easily produced and is mechanically stable and dissolves quickly. 
     SUMMARY OF THE INVENTION 
     According to the invention there is provided a method of producing effervescent tablets which consist of at least one active substance or a combination of active substances, of at least one binder, possibly of carriers as sweeteners, flavours, colourings, scents, softeners and bleaches, and of sherbets, wherein propylglycol or glycerin is used as a binder, wherein the active substance or the combination of active substances and possibly the carriers are mixed with the binder, wherein the sherbets are added to this mixture in an air-conditioned room and wherein the mixture including the sherbets is formed into tablets. 
     Further, according to the invention there is provided a effervescent tablet consisting of at least one active substance or one combination of active substances, of at least one binder, possibly of carriers as sweeteners, flavours, colourings, scents, softeners and bleaches, and of sherbets, which comprise propylglycol or glycerin as a binder. 
     Propylglycol or glycerin as a binder are only needed in small amounts to achieve the wanted mechanical characteristics of the effervescent tablets and to keep the wanted dissolving attitude. Handling the binder propylglycol or glycerin is also very simple. It can be mixed with the active substance or with the combination of active substances and possibly with the carrier without destroying their tipping ability and thus their simple ability to be mixed with the sherbets. At the same time there is no danger that the binder could cause a loss of carbon dioxide of the sherbets. 
     The active substances to be used in the method and for the effervescent tablet according to the invention are not limited at all. They include, for example, calcium, magnesium, potassium, iron-II-gluconate, vitamin E, vitamin C, paracetamol, cimetidine, piracetam, acetylsalicyl acid, ambroxol, indomethacin and acetylcysteine or any other active substance. 
     The combination of substances to be used includes for example multi vitamins, multi vitamins with minerals, beta carotin with vitamin E and/or vitamin C, vitamin C with minerals, anionic and/or not-ionic tensides or other washing active substances. Also all combinations of active substances which can be orally taken in solving form can be used. 
     The possibly used carriers can be flavourings such as sweeteners, sugar substitutes, flavours or additional or alternate further carriers as colourings or scents. These carriers are well known by those of ordinary skill in the art. The definite choice depends on the wanted result, especially with respect to the taste of the dissolved effervescent tablets, and lies within the knowledge of those skilled in the art. 
     Those skilled in the art also know possible compositions of sherbets for the effervescent tablets. These sherbets consist of a base component and an acid component wherein especially the acid component also can be used as an active substance. One known example thereof is ascorbic acid (vitamin C). Usually, as base component sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate and calcium carbonate are used. As an acid component besides ascorbic acid mono sodium citrate, wine acid and/or citric acid can be considered. 
     Advantageously, the method according to the invention includes intensely mixing the active substance or the combination of active substances and possibly carriers with the binder before adding the sherbets, and directly forming a mixture including the sherbets into tablets. Advantageously, in case of both the method and the effervescent tablet according to the invention the amount of binder is in the range of 0.004 to 2.5% per weight of the whole effervescent tablets, especially in the range of 0.004 to 1.5% per weight of the whole effervescent tablets, and more especially in the range of 0.01 to 1.0% per weight of the whole effervescent tablets. Further, the amount of sherbets advantageously is in the range of 58 to 93% per weight of the whole effervescent tablets, and especially in the range of 70 to 90% per weight of the whole effervescent tablets. 
     An important advantage of the new method of producing the effervescent tablets is the small apparatus and the short time needed by equally great freedom concerning the used active substances or combination of substances. Thus, the method can be used to produce pharmaceutical effervescent tablets as well as diet effervescent tablets and tablets for washing, bathing and decalcifying. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS 
     The invention will further be explained by means of the following examples and with reference to the following drawings in which 
     FIG. 1 is a flow-chart of a process according to the method of the invention and 
     FIG. 2 shows two effervescent tablets according to the invention, one in top view and the other one in side view. 
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     In all examples, the procedure follows the process shown in FIG. 1. An active substance or a combination of active substances 1 is mixed with sweeteners, fillers and colourings 2 as well as with flavours 3 in a high shear mixer 4. Afterwards, the binder 5 is sprayed upon the mixture and the mixture is once again intensely mixed. Then the content of the high shear mixer 4 is transferred over a sieve 6 with a mesh of 1 mm into a blender 7. In the blender 7 the sherbets which consist of an acid component 8 and a base component 9 are added. After mixing in the blender 7 the tablet blend is transferred to a tablet compressor 10. The resulting effervescent tablets then reach the filling machine 11. 
     In the following, the equipment is listed which is actually used in the examples: 
     Weighing 
     Floor balance 
     Type: ID 5 MULTIRANGE Manufacturer: Mettler, GieBen, Germany 
     Desk balance 
     Type: ID 5 MULTIRANGE Manufacturer: Mettler, GieBen, Germany 
     Manufacture of the tablet blend 
     
         ______________________________________High shear mixer/granulatorType: DIOSNA P 400         Manufacturer:                     Dierks &amp; Sohne,                     Osnabruck, GermanyOscillating sieveType: MGIF 634         Manufacturer:                     Frewitt,                     Fribourg, SwitzerlandBlenderType: PM 1000 Manufacturer:                     L.B. Bohle,                     Ennigerloh, Germany, orType: ROBA 500         Manufacturer:                     Peterhans,                     Dottikon, Switzerland______________________________________ 
    
     Tabletting 
     Tablet compressor with external lubrication device 
     Type: P 1000 Manufacturer: Fette, Schwarzenbek, Germany 
     Testing and In process control 
     
         ______________________________________Hardness testerType: 6 D    Manufacturer:                    Schleuniger,                    Solothurn, SwitzerlandDesk balanceType: 1408 0042        Manufacturer:                    Sartorius,                    Gottingen, Germany______________________________________ 
    
     EXAMPLE 1.1 
     Acetylsalicyl Acid 500 Mg Effervescent Tablet 
     
         ______________________________________100.000   kg         acetylsalicyl acid10.000    kg         primary sodium phosphate4.000     kg         Tylose C 300 P______________________________________ 
    
     are mixed for 3 min in the high shear mixer 4. 
     0.100 kg propylglycol are added and the mixture is once again briefly mixed. 
     The acetylsalicyl acid-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________186.000 kg       citric acid240.000 kg       sodium hydrogen carbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 539.900 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.100 kg magnesium stearate into 200.000 round tablets with a diameter of 22 mm and a tablet weight of 2.7 g. 
     The tablet hardness is 45 to 55 N. 
     EXAMPLE 1.2 
     Acetylsalicyl Acid+Vitamin C Effervescent Tablet 
     
         ______________________________________75.000    kg         acetylsalicyl acid18.750    kg         ascorbic acid3.000     kg         primary sodium phosphate1.350     kg         sodium saccharinate4.500     kg         fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer 4. 
     0.075 kg propylglycol are added and the mixture is once again briefly mixed. 
     The acetylsalicyl acid-vitamin C-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________182.400 kg         citric acid254.850 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 539.925 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.075 kg magnesium stearate into 150.000 round tablets with a diameter of 25 mm and a tablet weight of 3.6 g. 
     The tablet hardness is &gt;50 N after pressing &gt;100 N after further 24 h. 
     EXAMPLE 2.1 
     Paracetamol 50 Mg Effervescent Tablet 
     
         ______________________________________25.000     kg          Paracetamol1.750      kg          sodium saccharinate15.000     kg          maltodextrine4.000      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer 4. 
     0.150 kg propylglycol are added and the mixture is once again briefly mixed. 
     The Paracetamol-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________35.000 kg          citric acid69.000 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 149.900 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.100 kg magnesium stearate into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 3 g. 
     EXAMPLE 2.2 
     Paracetamol+Vitamin C Effervescent Tablet 
     
         ______________________________________25.000     kg          Paracetamol10.000     kg          ascorbic acid1.750      kg          sodium saccharinate7.500      kg          maltodextrine7.500      kg          Karion Instant4.000      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.150 kg propylglycol are added and this mixture is once again briefly mixed. 
     The Paracetamol-vitamin C-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________41.000 kg          citric acid53.250 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 150.150 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.100 kg magnesium stearate into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 3 g. 
     The tablet hardness is 30 to 50 N. 
     EXAMPLE 3.1 
     Acetylcysteine 100 mg Effervescent Tablet 
     
         ______________________________________5.000 kg            acetylcysteine1.000 kg            Aspartam2.000 kg            fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.0075 kg propylglycol are added and the mixture is once again briefly mixed. 
     The acetylcysteine-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________78.950 kg          citric acid58.030 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 144.975 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.025 kg magnesium stearate into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 2.9 g. 
     The tablet hardness is 40 to 50 N. 
     EXAMPLE 3.2 
     Acetylcysteine 400 mg Effervescent Tablet 
     
         ______________________________________20.000 kg           acetylcysteine1.000 kg            Aspartam2.500 kg            fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.006 kg propylglycol are added and the mixture is once again briefly mixed. 
     The acetylcysteine-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________66.650 kg          citric acid52.841 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 142.977 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.025 kg magnesium stearate into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 2.86 g. 
     The tablet hardness is 40 to 60 N. 
     EXAMPLE 4.1 
     Ambroxol 30 mg Effervescent Tablet 
     
         ______________________________________ 3.000 kg         Ambroxol 0.400 kg         sodium bicarbonate 1.125 kg         Aspartam 0.030 kg         Kollidon 25 0.050 kg         Macrogol 600025.510 kg         maltodextrine25.510 kg         Karion instant 5.000 kg         fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.375 kg propylglycol are added and the mixture is once again briefly mixed. 
     The Ambroxol-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________118.850 kg         citric acid100.150 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 280.000 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.050 kg magnesium stearate into 100.000 round tablets with a diameter of 22 mm and a tablet weight of 2.8 g. 
     The tablet hardness is &gt;50 N right after preforming. 
     EXAMPLE 4.2 
     Ambroxol 60 mg Effervescent Tablet 
     
         ______________________________________6.000      kg          Ambroxol0.500      kg          sodium saccharinate1.100      kg          Aspartam0.030      kg          Kollidon 250.050      kg          Macrogol 600023.160     kg          maltodextrine23.160     kg          Karion instant6.000      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.400 kg propylglycol are added and the mixture is once again briefly mixed. 
     The Ambroxol-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________119.180 kg         citric acid100.420 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 280.000 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.050 kg magnesium stearate into 100.000 round tablets with a diameter of 22 mm and a tablet weight of 2.8 g. 
     The tablet hardness is &gt;50 N directly right after pressing. 
     EXAMPLE 5 
     Cimetidine 200 mg Effervescent Tablet 
     
         ______________________________________10.000     kg          Cimetidine2.000      kg          sodium cyclamate0.500      kg          sodium saccharinate20.000     kg          sorbitol8.000      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.500 kg propylglycol are added and the mixture is once again briefly mixed. 
     The Cimetidine-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________42.500 kg          citric acid75.500 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 159.000 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.075 kg magnesium stearate into 100.000 round tablets with a diameter of 22 mm and a tablet weight of 3.18 g. 
     The tablet hardness is 40 to 70 N. 
     EXAMPLE 6.1 
     Vitamin C 225 mg Effervescent Tablet 
     
         ______________________________________11.250     kg          ascorbic acid1.000      kg          sodium cyclamate0.350      kg          sodium saccharinate0.005      kg          riboflavin20.000     kg          sorbitol2.500      kg          maltodextrine0.500      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.125 kg propylglycol are added and the mixture is once again briefly mixed. 
     The ascorbic acid-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________94.145 kg          citric acid70.000 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 199.875 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.125 kg magnesium stearate into 50.000 round tablets with a diameter of 25 mm and a tablet weight of 4 g. 
     EXAMPLE 6.2 
     Vitamin C 500 mg Effervescent Tablet 
     
         ______________________________________25.000     kg          ascorbic acid1.500      kg          sodium cyclamate0.500      kg          sodium saccharinate0.075      kg          riboflavin0.050      kg          beta-carotin6.000      kg          sorbitol1.500      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.250 kg propylglycol are added and the mixture is once again briefly mixed. 
     The ascorbic acid-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________29.000 kg          citric acid36.000 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 99.875 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.125 kg silicone oil into 50.000 round tablets with a diameter of 20 mm and a tablet weight of 2 g. 
     EXAMPLE 6.3 
     Vitamin C 1000 mg Effervescent Tablet 
     
         ______________________________________50.000     kg          ascorbic acid2.500      kg          sodium cyclamate0.500      kg          sodium saccharinate0.750      kg          Kollidon 304.000      kg          maltodextrine8.500      kg          sorbitol2.500      kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.500 kg propylglycol are added and the mixture is once again briefly mixed. 
     The ascorbic acid-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________0.500      kg          citric acid32.400     kg          mono sodium citrate29.750     kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 131.900 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.100 kg silicone oil into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 2.64 g. 
     EXAMPLE 7.1 
     Calcium Gluconate Effervescent Tablet 
     
         ______________________________________50.000    kg       calcium gluconate monohydrate2.000     kg       sodium cyclamate0.650     kg       sodium saccharinate0.005     kg       riboflavin4.000     kg       Karion Instant1.750     kg       fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.750 kg propylglycol are added and the mixture is once again briefly mixed. 
     The calcium-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________97.000 kg          citric acid54.000 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 210.200 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.050 kg magnesium stearate into 50.000 round tablets with a diameter of 25 mm and a tablet weight of 4.2 g. 
     The tablet hardness is 40 to 50 N. 
     EXAMPLE 7.2 
     Calcium 500 mg Effervescent Tablet 
     
         ______________________________________150.000 kg         calcium carbonate4.800 kg           sodium cyclamate1.440 kg           sodium saccharinate0.012 kg           riboflavin3.600 kg           Karion Instant4.200 kg           fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     3.600 kg propylglycol are added and the mixture is once again briefly mixed. 
     The calcium-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________433.788 kg         citric acid178.560 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 779.800 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.200 kg magnesium stearate into 120.000 round tablets with a diameter of 25 mm and a tablet weight of 6.5 g. 
     The tablet hardness is 40 to 50 N. 
     EXAMPLE 7.3 
     Calcium 500 mg Effervescent Tablet (Without Sodium) 
     
         ______________________________________62.500 kg          calcium carbonate1.000 kg           sodium cyclamate0.350 kg           sodium saccharinate2.000 kg           maltodextrine1.500 kg           fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     2.500 kg propylglycol are added and the mixture is once again briefly mixed. 
     The calcium-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________  100.000 kg    citric acid______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 169.850 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.150 kg silicone oil into 50.000 round tablets with a diameter of 22 mm and a tablet weight of 3.4 g. 
     EXAMPLE 7.4 
     Calcium+Vitamin C Effervescent Tablet 
     
         ______________________________________150.000 kg         calcium carbonate15.000 kg          ascorbic acid5.400 kg           sodium cyclamate1.440 kg           sodium saccharinate0.180 kg           riboflavin2.400 kg           beetroot powder4.620 kg           fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     3.000 kg propylglycol are added and the mixture is once again briefly mixed. 
     The calcium-vitamin C-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________426.360 kg         citric acid171.600 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 780.000 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.200 kg magnesium stearate into 120.000 round tablets with a diameter of 25 mm and a tablet weight of 6.5 g. 
     The tablet hardness is 40 to 50 N. 
     EXAMPLE 8.1 
     Magnesium 150 mg Effervescent Tablet 
     
         ______________________________________140.400 kg      magnesium hydroxide carbonate9.600 kg        sodium cyclamate3.000 kg        sodium saccharinate0.048 kg        riboflavin12.000 kg       maltodextrine12.480 kg       fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     7.200 kg propylglycol are added and the mixture is once again briefly mixed. 
     The magnesium-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________844.392 kg         citric acid530.880 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 1559.800 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.200 kg magnesium stearate into 240.000 round tablets with a diameter of 25 mm and a tablet weight of 6.5 g. 
     The tablet hardness is 50 to 70 N. 
     EXAMPLE 8.2 
     Magnesium+Vitamin C Effervescent Tablet 
     
         ______________________________________81.960 kg         magnesium carbonate15.000 kg         ascorbic acid 4.200 kg         sodium cyclamate 1.200 kg         sodium saccharinate12.000 kg         maltodextrine 4.800 kg         fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     3.600 kg propylglycol are added and the mixture is once again briefly mixed. 
     The magnesium-vitamin C-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________ 2.160 kg          beetroot powder 0.720 kg          riboflavin427.550 kg         citric acid226.800 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 779.800 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.200 kg magnesium stearate into 120.000 round tablets with a diameter of 25 mm and a tablet weight of 6.5 g. 
     The tablet hardness is 50 to 70 N. 
     EXAMPLE 9 
     Vitamin E Effervescent Tablet 
     
         ______________________________________7.500 kg           vitamin E acetate1.250 kg           sodium saccharinate28.000 kg          maltodextrine1.250 kg           beetroot powder0.250 kg           riboflavin2.000 kg           Karion Instant1.250 kg           fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     0.125 kg propylglycol are added and the mixture is once again briefly mixed. 
     The vitamin E-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________97.250 kg          citric acid66.000 kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 204.875 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.125 kg silicone oil into 50.000 round tablets with a diameter of 25 mm and a tablet weight of 4.1 g. 
     EXAMPLE 10.1 
     Multi-vitamin Effervescent Tablet 
     
         ______________________________________72.000 kg          multi-vitamin mixture 6.300 kg          sodium cyclamate 4.980 kg          sodium saccharinate40.500 kg          Karion Instant24.300 kg          maltodextrine 4.500 kg          fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     1.260 kg propylglycol are added and the mixture is once again briefly mixed. 
     The multi-vitamin-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________ 2.700 kg          beetroot powder404.460 kg         citric acid252.000 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 809.500 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.500 kg magnesium stearate into 180.000 round tablets with a diameter of 25 mm and a tablet weight of 4.5 g. 
     The tablet hardness is 70 to 80 N. 
     EXAMPLE 10.2 
     Multi-vitamin+Minerals Effervescent Tablet 
     
         ______________________________________72.000 kg      multi-vitamin mixture45.000 kg      calcium carbonate79.200 kg      potassium hydrogen phosphate21.870 kg      magnesium carbonate 6.300 kg      sodium saccharinate18.900 kg      maltodextrine 9.000 kg      fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     4.500 kg propylglycol are added and the mixture is once again briefly mixed. 
     The multi-vitamin-mineral-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________3.600      kg         beetroot powder400.500    kg         citric acid108.000    kg         sodium bicarbonate24.300     kg         sodium carbonate16.830     kg         potassium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 809.500 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.500 kg magnesium stearate into 180.000 round tablets with a diameter of 25 mm and a tablet weight of 4.5 g. 
     The tablet hardness is 80 to 90 N. 
     EXAMPLE 11 
     Carotin+Vitamin C+E Effervescent Tablet 
     
         ______________________________________14.000     kg         Protector Mixture3.750      kg         ascorbic acid0.500      kg         calcium pantothenate31.250     kg         calcium carbonate8.750      kg         magnesium carbonate0.0001     kg         Biotin1.500      kg         natrium cyclamate0.750      kg         natrium saccharinate2.500      kg         fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     1.000 kg propylglycol are added and the mixture is once again briefly mixed. 
     The carotin-vitamin E+C-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________126.000 kg         citric acid 30.000 kg         sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 219.875 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.125 kg silicone oil into 50.000 round tablets with a diameter of 25 mm and a tablet weight of 4.4 g. 280 mg Protector Mixture which are provided per effervescent tablet contain 6 mg beta-carotin, 12 mg vitamin E and 75 mg vitamin C. 
     EXAMPLE 12 
     Iron+Vitamin C Effervescent Tablet 
     
         ______________________________________38.850     kg        iron-II-gluconate hydrate31.250     kg        ascorbic acid0.0015     kg        vitamin B 120.050      kg        folic acid7.500      kg        sodium cyclamate4.500      kg        sodium saccharinate125.000    kg        maltodextrine15.000     kg        Karion Instant5.000      kg        fruit flavour______________________________________ 
    
     are mixed for 3 min in the high shear mixer. 
     1.250 kg propylglycol are added and the mixture is once again briefly mixed. 
     The iron-vitamin C-colouring-sweetener-flavour-concentrate is mixed in an air-conditioned room (relative humidity &lt;25%) in the blender 7 with 
     
         ______________________________________0.250      kg          riboflavin11.250     kg          beetroot powder810.100    kg          citric acid575.000    kg          sodium bicarbonate______________________________________ 
    
     for about 10 to 15 min. 
     The obtained 1624.502 kg tablet blend is pressed by a tablet compressor under external lubrication with less than 0.500 kg magnesium stearate into 250.000 round tablets with a diameter of 25 mm and a tablet weight of 6.5 g. 
     The tablet hardness is 45 to 60 N. 
     The following table 1 shows the dissolving time of the effervescent tablets of the examples 1 to 12. There, one can also see the amount of the sherbets and the amount of the binder each per weight of whole effervescent tablets. 
     The dissolving time is the time in which the effervescent tablets brought into water are dissolved and the gas production is completed without any particles remaining. The measuring of the dissolving time in seconds happens with each tablet being brought in 150 ml water at a temperature of 20° C. Therein, the dissolving time is determined by the mean. 
     Table 1 shows that effervescent tablets produced according to the method of the invention have a considerable shorter dissolving time compared to the dissolving time of 300 sec. according to the European Book of Pharmacy, 2nd edition. 
     It can also be seen that the amount of sherbets, which can be reliably introduced with the new binders into mechanically stable effervescent tablets, is very high. This is also a reason for the fast dissolving of the effervescent tablets besides the characteristics of the binder itself. If the amount of sherbets is noted as a range, this means that the active substance or parts of the combination of substances also function as sherbets. 
     On the other hand, the part of the active substance or of the combination of active substances, of the carriers, and of the binder which is the part of the tablet blend that is to be mixed in the high shear mixer is relatively small as compared to the whole weight of the effervescent tablets in comparison with the conditions known from literature. This means that the active substance or the combination of active substances can be more easily measured into exact doses. 
     The amount of binder in the new effervescent tablets is extremely small. 
     
                       TABLE 1______________________________________Effervescent tablets    dissolving   amount of amount ofExample  time [sec]   sherbets [%]                           binder [%]______________________________________1.1      &lt;60          78.89     0.01851.2      &lt;120         80.97     0.01392.1      150          69.33     0.10002.2      &lt;120         62.73     0.09983.1      &lt;60          94.47     0.00523.2      &lt;120         83.56     0.00424.1      &lt;70          78.21     0.13394.2      &lt;70          78.43     0.14295        &lt;100         74.21     0.31456.1      120          82.07     0.06256.2      180          65.00     0.25006.3      150          47.46-8.3 0.37887.1      100          71.90     0.35677.2      100          78.51     0.46157.3      180          58.82-9.5 1.47067.4       60          76.66     0.38468.1      100          88.16     0.46158.2      120          83.89     0.46159         90          79.63     0.061010.1      60          81.04     0.155610.2      90          67.86     0.555611       100          70.91     0.454512        45          85.23     0.0769______________________________________

Technology Classification (CPC): 8