Patent Abstract:
The present invention provides a high-throughput method for the parallel analysis of many potential sites of chemical modification (e.g., methylation) in DNA. It makes use of chemical treatment of the DNA to alter its sequence in a way that depends upon the modification of interest and subsequent analysis of the resulting sequence by hybridization to an array of probes. A device, comprising the array of probes, is provided by the invention, and principles and methods for its design and fabrication are also provided.

Full Description:
[0001]    This application claims priority to U.S. Provisional Patent Application Serial No. 60/301,370 filed Jun. 27, 2001. 
     
    
       [0002] The U.S. Government may own certain rights in this invention pursuant to the terms of the National Cancer Institute grant CA81656-01. 
     
    
     
       FIELD OF THE INVENTION  
         [0003]    The present invention relates generally to the analysis of chemically modified macromolecules, and specifically to the detection of modified sites in DNA with the use of oligonucleotide arrays.  
         BACKGROUND OF THE INVENTION  
         [0004]    Methylation of cytosines in CpG dinucleotides is an important mechanism of transcriptional regulation. It is involved in a variety of normal biological processes such as X chromosome inactivation and transcriptional regulation of imprinted genes. Aberrant methylation of cytosines can also effect transcriptional inactivation of certain tumor suppressor genes, associated with a number of human cancers. Cytosine methylation in CpG-rich areas (CpG islands) located in the promoter regions of some genes is of special regulatory importance. Therefore, wide scope mapping of methylation sites in CpG islands is important for understanding both normal and pathological cellular processes. Furthermore, methylation of certain sites may serve as an important marker for early diagnosis and treatment decisions of some cancers.  
           [0005]    A variety of methods have been used to identify sites of DNA methylation. One common method has relied on the inability of restriction endonucleases to cleave sequences that contain one or more methylated cytosines. Genomic DNA is fragmented with appropriate restriction enzymes and cleavage at the site of interest is probed electrophoretically or by PCR. This method provides an analysis of some potential methylation sites, but it is limited to sites that fall within the recognition sequences of methylation-sensitive restriction enzymes.  
           [0006]    Other methods rely on the differential chemical reactivities of cytosine and 5-methyl cytosine with reagents such as sodium bisulfite, hydrazine, or permanganate. In the case of hydrazine and permanganate, differential strand cleavage between methylated and unmethylated cytosines is examined in a similar fashion to that used when cleavage is done with restriction enzymes. This approach is complicated by the imperfect specificity of the reagents between methylated and unmethylated cytosines and by interference from reaction with thymidines.  
           [0007]    Treatment with sodium bisulfite can be used to convert methylated and unmethylated DNA to different sequences. Under appropriate conditions, unmethylated cytosines in DNA react with sodium bisulfite to yield deoxyuridine, which behaves as thymidine in Watson-Crick hybridization and enzymatic template-directed polymerization. Methylated cytosines, however, are unreactive, and behave as cytosine in Watson-Crick hybridization and enzymatic template-directed polymerization.  
           [0008]    The sequence differences resulting from bisulfite treatment can be assessed in any of several ways. One way is with standard sequencing by primer extension (Sanger sequencing). This method has the disadvantage of limited throughput. Another way, termed methylation-specific PCR, uses a set of PCR primers specific to the sequences resulting from bisulfite treatment of either methylation state at a given site. Effective amplification using one primer from the set indicates methylation, whereas effective amplification using the other primer indicates unmethylated cytosine at the site being amplified. This method has the disadvantage of low sample throughput in addition to the disadvantage that only one potential site of methylation is probed in an assay.  
           [0009]    Thus, there is a need for a high throughput method for the identification of alteration in DNA.  
         SUMMARY OF THE INVENTION  
         [0010]    The present invention provides a high-throughput method for the parallel analysis of many potential sites of chemical modification (e.g., methylation) in DNA. It makes use of chemical treatment of the DNA to alter its sequence in a way that depends upon the modification of interest and subsequent analysis of the resulting sequence by hybridization to an array of probes. A device, comprising the array of probes, is provided by the invention, and principles and methods for its design and fabrication are also provided.  
           [0011]    In one form the present is a method for the analysis of chemical modification of DNA including the steps of obtaining a sample of DNA to be analyzed and treating the DNA with one or more chemical reagents that result in different base sequences depending upon the presence or absence of the modification of interest, and determining a portion of the base sequence of the resulting DNA.  
           [0012]    Another form of the present invention is an array of one or more nucleic acid probes immobilized on a solid support wherein the probes are designed to detect sites of methylation in DNA.  
           [0013]    Yet another form of the invention is a method for generating DNA probe sequences that includes the steps of inputting a nucleic acid sequence in the 3-prime to 5-prime direction and converting the sequence to account for chemical modification. The complementary sequence to the converted sequence in the 3-prime to 5-prime direction is then generated. A first parent probe is then generated by choosing a first starting position on the complementary sequence and a first ending position on the complementary sequence. A second parent probe is then generated by moving the first starting and first ending position one base unit in the same direction. This process may be repeated as often as desired.  
           [0014]    Another form of the resent invention is a method for generating DNA probe sequences that includes the steps of inputting a nucleic acid sequence in the 3-prime to 5-prime direction and converting the sequence to account for chemical modification. The complementary sequence to the converted sequence in the 3-prime to 5-prime direction is then generated. The complementary sequence is then examined to locate one or more CpG dinucleotide regions within the complementary sequence, and probes are then generated that have one or more nucleic acid bases on each end of the CpG dinucleotide regions. 
       
    
    
     BRIEF DESCRIPTION OF THE FIGURES  
       [0015]    The above and further advantages of the invention may be better understood by referring to the following detailed description in conjunction with the accompanying drawings in which corresponding numerals in the different FIGURES refer to the corresponding parts in which:  
         [0016]    [0016]FIG. 1 depicts a reaction in accordance with the present invention;  
         [0017]    [0017]FIG. 2 depicts a method of re-sequencing in accordance with the present invention;  
         [0018]    [0018]FIG. 3 depicts a schematic of assay results in accordance with the present invention;  
         [0019]    [0019]FIG. 4 depicts the results of a two-color assay in accordance with the present invention;  
         [0020]    [0020]FIG. 5 depicts a fluorescence scan in accordance with the present invention;  
         [0021]    [0021]FIG. 6 depicts an assay for CpG methylation by (A) treatment with sodium bisulfite to convert unmethylated cytosines to deoxyuracils (4 cytosines) while methylated cytosines remain unconverted (one cytosine denoted as methylated with a superscript Me) and (B) sequence analysis of a labeled representative of the bisulfite-treated DNA by hybridization to an array of oligonucleotides in accordance with the present invention;  
         [0022]    [0022]FIG. 7 depicts the sequence of the 190 base region of the p16 promoter wherein each cytosine in the sequence is numbered in accordance with the present invention;  
         [0023]    [0023]FIG. 8 depicts four probes from an array used to analyze the methylation state of a region of the promoter for p16 showing (A) fluorescence scan of the Cy5 (analyte) channel of the array, (B) fluorescence scan of the Cy3 (reference) channel of the array, (C) overlay of the analyte and reference channels demonstrating the appearance of a methylated site compared with an unmethylated reference in accordance with the present invention; and  
         [0024]    [0024]FIG. 9 is a histogram plots showing Z scores for each cytosine in a CpG dinucleotide using analysis in which the analyte was derived from (A) uniformly methylated DNA, (B) a synthetic duplex simulating unique methylation at cytosine number 25, (C) a mixture of approximately 20% methylated DNA and 80% unmethylated DNA in accordance with the present invention. 
     
    
     DETAILED DESCRIPTION  
       [0025]    While the making and using of various embodiments of the present invention are discussed herein in terms of identification of methylated sites in DNA, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention and are not meant to limit the scope of the invention in any manner.  
         [0026]    The need for high-throughput methods is highlighted by the prevalence of CpG islands in the genome. Computer analysis of the March 2001 Unigene build reveals 32,597 of the 92,152 clusters contain CpG islands. Of the 14,968 clusters with annotation, 10,438 have CpG islands. These islands in the annotated clusters comprise 4,398,560 bp in 5′ non-coding regions, 7,074,411 bp in coding regions, and 492,323 bp in 3′ non-coding regions. A high throughput method of the present invention will be necessary to interrogate even a small fraction of these sites in a given experiment.  
         [0027]    The differential reactivity of bisulfite with cytosine and 5-methylcytosine forms the basis of several techniques for the assessment of DNA methylation; however, new approaches to the read-out of the sequence that results from treatment with bisulfite are desirable. Sequence analysis by hybridization to oligonucleotide arrays is an approach that affords a high degree of parallelism and flexibility. The present invention relies on discrimination between a cytosine and a thymidine in the array hybridization.  
         [0028]    All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, unless defined otherwise. Methods and materials similar or equivalent to those described herein may be used in the practice or testing of the present invention, the generally used methods and materials are now described.  
         [0029]    Definitions  
         [0030]    To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not limit the invention, except as outlined in the claims.  
         [0031]    As used throughout the present specification the following abbreviations are used: TF, transcription factor; ORF, open reading frame; kb, kilobase (pairs); UTR, untranslated region; kD, kilodalton; PCR, polymerase chain reaction; RT, reverse transcriptase.  
         [0032]    The term “homology” refers to the extent to which two nucleic acids are complementary. There may be partial or complete homology. A partially complementary sequence is one that at least partially inhibits a completely complementary sequence from hybridizing to a target nucleic acid and is referred to using the functional term “substantially homologous.” The degree or extent of hybridization may be examined using a hybridization or other assay (such as a competitive PCR assay) and is meant, as will be known to those of skill in the art, to include specific interaction even at low stringency.  
         [0033]    The art knows that numerous equivalent conditions may be employed to achieve low stringency conditions. Factors that affect the level of stringency include: the length and nature (DNA, RNA, base composition) of the probe and nature of the target (DNA, RNA, base composition, present in solution or immobilized, etc.) and the concentration of the salts and other components (e.g., formamide, dextran sulfate, polyethylene glycol). Likewise, the hybridization solution may be varied to generate conditions of low stringency hybridization different from, but equivalent to, the above listed conditions. In addition, the art knows conditions that promote hybridization under conditions of high stringency (e.g., increasing the temperature of the hybridization and/or wash steps, inclusion of formamide, etc.).  
         [0034]    The term “gene” is used to refer to a functional protein, polypeptide or peptide-encoding unit. As will be understood by those in the art, this functional term includes genomic sequences, cDNA sequences, or fragments or combinations thereof, as well as gene products, including those that may have been altered by the hand of man. Purified genes, nucleic acids, protein and the like are used to refer to these entities when identified and separated from at least one contaminating nucleic acid or protein with which it is ordinarily associated.  
         [0035]    The term “portion of a genome for genetic analysis” or “chromosome-specific” is herein defined to encompass the terms “target specific” and “region specific”, that is, when the staining composition is directed to one chromosome or portion of a genome, it is chromosome-specific, but it is also chromosome-specific when it is directed, for example, to multiple regions on multiple chromosomes, or to a region of only one chromosome, or to regions across the entire genome. Likewise, “locus specific” or “loci specific” is defined as locations on one or more chromosomes for a particular gene or allele. Sequence from regions of one or more chromosomes are sources for probes for that region or those regions of the genome. The probes produced from such source material are region-specific probes but are also encompassed within the broader phrase “portion of a genome” probes. The term “target specific” is interchangeably used herein with the term “chromosome-specific” and “portion of a genome”.  
         [0036]    The word “specific” as commonly used in the art has two somewhat different meanings. The practice is followed herein. “Specific” refers generally to the origin of a nucleic acid sequence or to the pattern with which it will hybridize to a genome, e.g., as part of a staining reagent. For example, isolation and cloning of DNA from a specified chromosome results in a “chromosome-specific library.” Shared sequences are not chromosome-specific to the chromosome from which they were derived in their hybridization properties since they will bind to more than the chromosome of origin. A sequence is “locus specific” if it binds only to the desired portion of a genome. Such sequences include single-copy sequences contained in the target or repetitive sequences, in which the copies are contained predominantly in the selected sequence.  
         [0037]    A “probe” as defined herein may be one or more molecules that can hybridize to a nucleic acid target sequence and that can be detected (e.g., nucleic acid fragments or other oligomers that bind nucleic acids). Examples of possible probe molecules include, but are not limited to, DNA, RNA, peptides, minor groove-binding polyamides, peptide nucleic acids (PNA), locked nucleic acids (LNA), and 2′-O-methyl nucleic acids. The probe is labeled so that its binding to the target can be assayed, visualized or detected. In essence the probe is designed to bind a target, also referred to as an analyte, so that the combination of probe and analyte may be assayed, visualized or detected. The probe may be produced from some source of nucleic acid sequences, for example, a collection of clones or a collection of polymerase chain reaction (PCR) products or the product of nick translation or other methods for adding a detectable marker to a nucleic acid binding moiety. For nucleic acids, repetitive sequences are removed or blocked with unlabeled nucleic acid with complementary sequence, so that hybridization with the resulting probe produces staining of sufficient contrast on the target. The word probe may be used herein to refer not only to a molecule that detects a nucleic acid, but also to the detectable nucleic acid in the form in which it is applied to, e.g., the surface of an array. What “probe” refers to specifically should be clear to those of skill in the art from the context in which the word is used.  
         [0038]    The term “labeled” as used herein indicates that there is some method to visualize or detect the bound probe, whether or not the probe directly carries some modified constituent. The terms “staining” or “painting” are herein defined to mean hybridizing a probe of this invention to a genome or segment thereof, such that the probe reliably binds to the targeted region or sequence of chromosomal material and the bound probe is capable of being detected. The terms “staining” or “painting” are used interchangeably. The patterns on the array resulting from “staining” or “painting” are useful for cytogenetic analysis, more particularly, molecular cytogenetic analysis. The staining patterns facilitate the high-throughput identification of normal and abnormal chromosomes and the characterization of the genetic nature of particular abnormalities.  
         [0039]    Multiple methods of probe detection may be used with the present invention, e.g., the binding patterns of different components of the probe may be distinguished, for example, by color or differences in wavelength emitted from a labeled probe.  
         [0040]    A number of different aberrations may be detected with any desired staining pattern on the portions of the genome detected with one or more colors (a multi-color staining pattern) and/or other indicator methods.  
         [0041]    The complexity for a final probe list and array will depend on the application for which it is designed (e.g., location on the genome, complexity of the sequence, etc.) and the mapping resolution that is sought. In general, the larger the target area, the more complex the probe list. The term “complexity” therefore refers to the complexity of the total probe list no matter how many visually distinct loci are to be detected, that is, regardless of the distribution of the target sites over the genome.  
         [0042]    The required contrast (e.g., signal to noise) for detection will depend on the application for which the probe is designed and even the portion of the genome that is the target of the analysis. When visualizing chromosomes and nuclei, etc., microscopically, a contrast ratio of two or greater is often sufficient for identifying whole chromosomes. When quantifying the amount of target region present on an array by fluorescence intensity measurements using a slide reader or quantitative microscopy.  
         [0043]    Identification of a large number of individual methylation sites in a high-throughput, highly parallel assay can be accomplished by specifically converting only unmethylated cytosines to deoxyuridines with sodium bisulfite treatment, as shown in FIG. 1, and rapidly reading out the resulting sequence. Any cytosine remaining in the product is identified as a site of methylation. Oligonucleotide arrays are particularly well suited to rapidly distinguishing between closely related nucleic acid sequences with a method known as re-sequencing.  
         [0044]    The method of re-sequencing is depicted in FIG. 2. A sequence of interest is shown in FIG. 2A, where an unknown base is at a central position, identified in the FIGURE with an N. FIG. 2B shows four oligonucleotide probes used to assay each base position of interest, each probe complementary to the sequence being tested except at the position of the unknown base. At the position of the unknown base, the probes differ, each having a different one of the four possible bases. The probe oligonucleotides may be immobilized on a surface as shown in FIG. 2, but other formats are possible. FIG. 2C shows the DNA to be tested binding to one of the four probes. It binds specifically to the probe with an adenosine in the test position, identifying the unknown base, N, as a thymidine. Specificity is highest when the probed base binds near the center of probe oligonucleotide.  
         [0045]    In practice, re-sequencing with oligonucleotide arrays can be accomplished by a number of means, any of which will be applicable to the present invention. In one standard approach, the array of oligonucleotides is immobilized on a glass surface. An example of a “feature” of the resulting array is defined as a region of the surface in which a single probe sequence predominates. Fabrication of surface-bound oligonucleotide arrays can also be accomplished by a variety of methods known to those with skill in the art.  
         [0046]    A fabrication method that is particularly appropriate for the present invention makes use of light directed chemistry to synthesize the oligonucleotides directly on the surface. The regions of the surface that are illuminated during pre-determined chemical steps of the synthesis determine the sequence synthesized in each feature. Defined regions can be illuminated discretely by, for example, shining light through a physical mask that blocks light from particular regions or by directing light to particular regions with a digital micromirror array. These light-directed approaches are desirable for the present invention, because they currently enable the largest numbers of features per unit area of array surface. Thus, the potential of the current invention for highly parallel analysis of methylation is best met by the very high feature numbers accessible with light-directed methods. However, other methods of array fabrication are amenable to the present invention, including but not limited to delivering the reagents of DNA synthesis to specific regions of the surface and depositing on the surface oligonucleotides that have been pre-synthesized.  
         [0047]    Typically, a solution of the nucleic acid to be analyzed is applied to the surface of the array, and the dissolved nucleic acid is allowed to bind to probes on the surface. After an appropriate time, the unbound and the weakest bound nucleic acid are washed from the array and the bound nucleic acid is detected. Detection of binding can be accomplished in several ways known to those of skill in the art, any of which can be applied to the present invention. In one method, detection is accomplished by labeling the test nucleic acid with a moiety such as a fluorophore and measuring fluorescence associated with each probe. FIG. 2D schematically illustrates the appearance of a fluorescence scan of four features designed to probe a single base following binding and washing. The brightest feature indicates the identity of the probed base position. Many methods are also known for the incorporation of a fluorescent label into a test nucleic acid, including but not limited to nick translation, transcription into RNA using a template-directed RNA polymerase to incorporate labeled nucleotide triphosphates, or amplifying a region of interest with PCR using labeled primers.  
         [0048]    In operation, the present invention may be used, for example, as described herein. A sample of genomic DNA to be analyzed is obtained and treated with bisulfite under conditions for which that reaction converts unmethylated cytosines to deoxyuridines but does not effect methylated cytosines. One or more regions of interest from the resulting DNA are then amplified by PCR and labeled by any of a variety of methods. Design of primers for PCR amplification of bisulfite-treated DNA should be guided by the following considerations: 1) the primers should not contain CpG dinucleotides of unknown methylation state, 2) the primers are restricted to a three-base code (A, G, and T) because all cytosines not in CpG dinucleotides are converted to deoxyuridine, 3) some bisulfite treatment protocols, such as the one described below, cleave the DNA substantially, so amplification of short regions (about 200 base pairs) is most successful, and 4) a different set of primers is required for each strand, because the two initially complementary strands are no longer complementary after bisulfite treatment.  
         [0049]    A solution of the labeled nucleic acid is then contacted with an array of probes comprising probes that bind differentially to the sequences resulting from bisulfite treatment of methylated or unmethylated cytosines of interest. In practice, such probes can be made by creating oligonucleotides that are complementary to a region of DNA surrounding the cytosine of interest, taking into account the conversion of all cytosines not in a CpG dinucleotide to deoxyuridine, which is complementary to adenosine. A typical length for such oligonucleotide probes is between 15 and 30 nucleotides, but longer and shorter probes are possible. The site to be probed should be near the center of the region to which the probe is complementary.  
         [0050]    At least two probes are required for each potential methylation site of interest. In one, the base in apposition to the site to be probed is an adenosine, forming the complement to the deoxyuridine-containing sequence corresponding to the unmethylated state. In the other, the base at the same position is guanosine, forming the complement to the cytosine-containing sequence corresponding to the methylated state. Although methylation state can be determined with these two probes only, it is preferable to use four probes for every site, one with each of the four bases at he variable position, in order to account for the possibility of polymorphism or mutation at the site of interest. Possible results of this assay are shown schematically in FIG. 3. FIG. 3A illustrates a result indicating methylation of the site of interest, the brightest feature being that corresponding to cytosine. FIG. 3B illustrates a result indicating absence of methylation at the site of interest, the brightest feature being that corresponding to thymidine. FIG. 3C illustrates a result indicating polymorphism or mutation at the site of interest to an adenosine.  
         [0051]    Multiple CpG dinucleotides of unknown methylation state will often be sufficiently proximal to each other in sequences to be analyzed that the probe will include one or more CpG dinucleotides in addition to the central one being analyzed. If a methylation state is assumed for these additional sites in the design of the probe sequence, the probe affinity for the analyte will be diminished whenever the assumed methylation state is not the actual methylation state. Including on the array additional probes that accommodate all possible methylation states can compensate for the resulting decrease in signal.  
         [0052]    The array may comprise probes that have been selected by visual inspection of the sequences to be probed or probes that have been selected by automated computational means. Because the present invention is most advantageous when probing a large number of sites in parallel, the preferred method of probe choice is by automated computational means. A process for probe selection is outlined below. Automated searching of genome databases can identify regions of particular interest with a high density of CpG dinucleotides.  
         [0053]    Two or more labels, such as fluorophores with different excitation and emission frequencies, can be used to compare one or more test samples with a reference sample. The reference sample can be a standard of known methylation state, a DNA sample from a reference tissue, such as a healthy tissue proximal to a diseased tissue to be tested, or a sample from the same cellular source as the test sample that has not been treated with bisulfite. The use of a reference sample of known methylation state provides an internal control for expected relative binding to probes, resulting in higher confidence in assignment of methylation state of unknown samples. The use of a reference sample from a reference tissue provides facile identification of methylation that is related to a particular phenotype, such as a disease phenotype. The use of a reference sample from the same cellular source as the test sample provides control for the possibility of a cytosine to thymidine mutation or polymorphism.  
         [0054]    Possible results of a two-color assay with an unmethylated reference sample are shown in FIG. 4. The reference sample is labeled with the red dye, and the sample to be analyzed is labeled with the green dye. FIG. 4A illustrates a result indicating methylation of the site of interest, the brightest green feature being that corresponding to cytosine and the brightest red feature corresponding to thymidine. FIG. 4B illustrates a result indicating absence of methylation at the site of interest, the brightest feature in both data channels being that corresponding to thymidine. FIG. 4C illustrates a result indicating polymorphism or mutation at the site of interest to an adenosine.  
         [0055]    The probes of the array need not be restricted to DNA. Any molecule that binds differentially to the sequences resulting from bisulfite treatment of methylated and unmethylated DNA can be used. Examples of possible probe molecules include, but are not limited to, RNA, peptides, minor groove-binding polyamides, peptide nucleic acids (PNA), locked nucleic acids (LNA), and 2′-O-methyl nucleic acid.  
       EXAMPLE 1  
     Analysis of Methylation of a Region of the Promoter for the Tumor Suppressor Gene p16  
       [0056]    Genomic DNA was isolated from two lines of lung tumor cells, H69 and H1618. The promoter region of the tumor suppressor gene P16 is known to be methylated at cytosines in CpG dinucleotides in the line H1618 and is not methylated in the line H69. DNA from both lines was treated with sodium bisulfite as described in the protocol below, which converts unmethylated cytosine to deoxyuridine (essentially equivalent to thymidine in hybridization) but does not react with methylated cytosine. A 145 base pair region from the p16 promoter from each cell line was amplified with labeled primers. Primers labeled with Cy5 were used to amplify the unmethylated promoter (which represents a control or reference sequence) and primers labeled with Cy3 were used to amplify the methylated promoter (which represents the unknown methylation state to be analyzed).  
         [0057]    The two samples were mixed together with the labeled control oligonucleotide and applied to the array. The array, fabricated by light-directed chemistry using a digital micromirror array, had two sets of features in addition to the control features. One set of features (upper half of array) was a standard re-sequencing tiling for the sequence expected without methylation (i.e., all Cs converted to T). The other set was a standard re-sequencing tiling for the sequence expected with methylation of every C in each CpG step. The set of probes used in the array appears as TABLE 1. A two-color fluorescence scan of the array after hybridization for 16 hours at room temperature and washing with 1×SSPE is shown in FIG. 5. Overall methylation state is evident by the labeled sample which binds best to each set of features, the Cy5 labeled, unmethylated sample binding best to the upper tiles for unmethylated sequence (highest signal red) and the Cy3 labeled, methylated sample binding best to the lower tiles for methylated sequence (highest signal green). Specific sites of methylation can be observed by reading sequence directly and by visually identifying columns in which the feature for C is green and the feature for T is red (easily visualized in both sets of probes).  
                             TABLE 1                           Probes Used in the Array            SEQ ID NO   Nucleotide Sequence for Probe               SEQ ID NO: 1   AACCAACCAATAATCTCCCAC                   SEQ ID NO: 2   ACCAACCAATTATCTCCCACC               SEQ ID NO: 3   CCAACCAATATTCTCCCACCC               SEQ ID NO: 4   CAACCAATAATCTCCCACCCC               SEQ ID NO: 5   AACCAATAATTTCCCACCCCA               SEQ ID NO: 6   ACCAATAATCTCCCACCCCAC               SEQ ID NO: 7   CCAATAATCTTCCACCCCACC               SEQ ID NO: 8   CAATAATCTCTCACCCCACCT               SEQ ID NO: 9   AATAATCTCCTACCCCACCTA               SEQ ID NO: 10   ATAATCTCCCTCCCCACCTAA               SEQ ID NO: 11   TAATCTCCCATCCCACCTAAC               SEQ ID NO: 12   AATCTCCCACTCCACCTAACT               SEQ ID NO: 13   ATCTCCCACCTCACCTAACTC               SEQ ID NO: 14   TCTCCCACCCTACCTAACTCA               SEQ ID NO: 15   CTCCCACCCCTCCTAACTCAC               SEQ ID NO: 16   TCCCACCCCATCTAACTCACA               SEQ ID NO: 17   CCCACCCCACTTAACTCACAC               SEQ ID NO: 18   CCACCCCACCTAACTCACACA               SEQ ID NO: 19   CACCCCACCTTACTCACACAA               SEQ ID NO: 20   ACCCCACCTATCTCACACAAA               SEQ ID NO: 21   CCCCACCTAATTCACACAAAC               SEQ ID NO: 22   CCCACCTAACTCACACAAACC               SEQ ID NO: 23   CCACCTAACTTACACAAACCA               SEQ ID NO: 24   CACCTAACTCTCACAAACCAC               SEQ ID NO: 25   ACCTAACTCATACAAACCACC               SEQ ID NO: 26   ATATAGTTTCGTCATTCATC               SEQ ID NO: 27   TACATTGCCCATGTAATTAA               SEQ ID NO: 28   ATATAGTTTCGTCATTCATC               SEQ ID NO: 29   TACATTGCCCATGTAATTAA               SEQ ID NO: 30   AGATAGTTTTGTCATTCATC               SEQ ID NO: 31   AGATAGTTTCTTCATTCATC               SEQ ID NO: 32   AGATAGTTTCGTCATTCATC               SEQ ID NO: 33   AGATAGTTTCGTTATTCATC               SEQ ID NO: 34   CCTAACTCACTCAAACCACCA               SEQ ID NO: 35   CTAACTCACATAAACCACCAA               SEQ ID NO: 36   TAACTCACACTAACCACCAAC               SEQ ID NO: 37   AACCAACCAAGAATCTCCCAC               SEQ ID NO: 38   ACCAACCAATGATCTCCCACC               SEQ ID NO: 39   CCAACCAATAGTCTCCCACCC               SEQ ID NO: 40   CAACCAATAAGCTCCCACCCC               SEQ ID NO: 41   AACCAATAATGTCCCACCCCA               SEQ ID NO: 42   ACCAATAATCGCCCACCCCAC               SEQ ID NO: 43   CCAATAATCTGCCACCCCACC               SEQ ID NO: 44   CAATAATCTCGCACCCCACCT               SEQ ID NO: 45   AATAATCTCCGACCCCACCTA               SEQ ID NO: 46   ATAATCTCCCGCCCCACCTAA               SEQ ID NO: 47   TAATCTCCCAGCCCACCTAAC               SEQ ID NO: 48   AATCTCCCACGCCACCTAACT               SEQ ID NO: 49   ATCTCCCACCGCACCTAACTC               SEQ ID NO: 50   TCTCCCACCCGACCTAACTCA               SEQ ID NO: 51   CTCCCACCCCGCCTAACTCAC               SEQ ID NO: 52   TCCCACCCCAGCTAACTCACA               SEQ ID NO: 53   CCCACCCCACGTAACTCACAC               SEQ ID NO: 54   CCACCCCACCGAACTCACACA               SEQ ID NO: 55   CACCCCACCTGACTCACACAA               SEQ ID NO: 56   ACCCCACCTAGCTCACACAAA               SEQ ID NO: 57   CCCCACCTAAGTCACACAAAC               SEQ ID NO: 58   CCCACCTAACGCACACAAACC               SEQ ID NO: 59   CCACCTAACTGACACAAACCA               SEQ ID NO: 60   CACCTAACTCGCACAAACCAC               SEQ ID NO: 61   ACCTAACTCAGACAAACCACC               SEQ ID NO: 62   TACATTGCCCATGTAATTAA               SEQ ID NO: 63   ATATAGTTTCGTCATTCATC               SEQ ID NO: 64   TACATTGCCCATGTAATTAA               SEQ ID NO: 65   ATATAGTTTCGTCATTCATC               SEQ ID NO: 66   AGATAGTTTGGTCATTCATC               SEQ ID NO: 67   AGATAGTTTCGTCATTCATC               SEQ ID NO: 68   AGATAGTTTCGGCATTCATC               SEQ ID NO: 69   AGATAGTTTCGTGATTCATC               SEQ ID NO: 70   CCTAACTCACGCAAACCACCA               SEQ ID NO: 71   CTAACTCACAGAAACCACCAA               SEQ ID NO: 72   TAACTCACACGAACCACCAAC               SEQ ID NO: 73   AACCAACCAACAATCTCCCAC               SEQ ID NO: 74   ACCAACCAATCATCTCCCACC               SEQ ID NO: 75   CCAACCAATACTCTCCCACCC               SEQ ID NO: 76   CAACCAATAACCTCCCACCCC               SEQ ID NO: 77   AACCAATAATCTCCCACCCCA               SEQ ID NO: 78   ACCAATAATCCCCCACCCCAC               SEQ ID NO: 79   CCAATAATCTCCCACCCCACC               SEQ ID NO: 80   CAATAATCTCCCACCCCACCT               SEQ ID NO: 81   AATAATCTCCCACCCCACCTA               SEQ ID NO: 82   ATAATCTCCCCCCCCACCTAA               SEQ ID NO: 83   TAATCTCCCACCCCACCTAAC               SEQ ID NO: 84   AATCTCCCACCCCACCTAACT               SEQ ID NO: 85   ATCTCCCACCCCACCTAACTC               SEQ ID NO: 86   TCTCCCACCCCACCTAACTCA               SEQ ID NO: 87   CTCCCACCCCCCCTAACTCAC               SEQ ID NO: 88   TCCCACCCCACCTAACTCACA               SEQ ID NO: 89   CCCACCCCACCTAACTCACAC               SEQ ID NO: 90   CCACCCCACCCAACTCACACA               SEQ ID NO: 91   CACCCCACCTCACTCACACAA               SEQ ID NO: 92   ACCCCACCTACCTCACACAAA               SEQ ID NO: 93   CCCCACCTAACTCACACAAAC               SEQ ID NO: 94   CCCACCTAACCCACACAAACC               SEQ ID NO: 95   CCACCTAACTCACACAAACCA               SEQ ID NO: 96   CACCTAACTCCCACAAACCAC               SEQ ID NO: 97   ACCTAACTCACACAAACCACC               SEQ ID NO: 98   ATATAGTTTCGTCATTCATC               SEQ ID NO: 99   TACATTGCCCATGTAATTAA               SEQ ID NO: 100   ATATAGTTTCGTCATTCATC               SEQ ID NO: 101   TACATTGCCCATGTAATTAA               SEQ ID NO: 102   AGATAGTTTCGTCATTCATC               SEQ ID NO: 103   AGATAGTTTCCTCATTCATC               SEQ ID NO: 104   AGATAGTTTCGCCATTCATC               SEQ ID NO: 105   AGATAGTTTCGTCATTCATC               SEQ ID NO: 106   CCTAACTCACCCAAACCACCA               SEQ ID NO: 107   CTAACTCACACAAACCACCAA               SEQ ID NO: 108   TAACTCACACCAACCACCAAC               SEQ ID NO: 109   AACCAACCAAAAATCTCCCAC               SEQ ID NO: 110   ACCAACCAATAATCTCCCACC               SEQ ID NO: 111   CCAACCAATAATCTCCCACCC               SEQ ID NO: 112   CAACCAATAAACTCCCACCCC               SEQ ID NO: 113   AACCAATAATATCCCACCCCA               SEQ ID NO: 114   ACCAATAATCACCCACCCCAC               SEQ ID NO: 115   CCAATAATCTACCACCCCACC               SEQ ID NO: 116   CAATAATCTCACACCCCACCT               SEQ ID NO: 117   AATAATCTCCAACCCCACCTA               SEQ ID NO: 118   ATAATCTCCCACCCCACCTAA               SEQ ID NO: 119   TAATCTCCCAACCCACCTAAC               SEQ ID NO: 120   AATCTCCCACACCACCTAACT               SEQ ID NO: 121   ATCTCCCACCACACCTAACTC               SEQ ID NO: 122   TCTCCCACCCAACCTAACTCA               SEQ ID NO: 123   CTCCCACCCCACCTAACTCAC               SEQ ID NO: 124   TCCCACCCCAACTAACTCACA               SEQ ID NO: 125   CCCACCCCACATAACTCACAC               SEQ ID NO: 126   CCACCCCACCAAACTCACACA               SEQ ID NO: 127   CACCCCACCTAACTCACACAA               SEQ ID NO: 128   ACCCCACCTAACTCACACAAA               SEQ ID NO: 129   CCCCACCTAAATCACACAAAC               SEQ ID NO: 130   CCCACCTAACACACACAAACC               SEQ ID NO: 131   CCACCTAACTAACACAAACCA               SEQ ID NO: 132   CACCTAACTCACACAAACCAC               SEQ ID NO: 133   ACCTAACTCAAACAAACCACC               SEQ ID NO: 134   TACATTGCCCATGTAATTAA               SEQ ID NO: 135   ATATAGTTTCGTCATTCATC               SEQ ID NO: 136   TACATTGCCCATGTAATTAA               SEQ ID NO: 137   ATATAGTTTCGTCATTCATC               SEQ ID NO: 138   AGATAGTTTAGTCATTCATC               SEQ ID NO: 139   AGATAGTTTCATCATTCATC               SEQ ID NO: 140   AGATAGTTTCGACATTCATC               SEQ ID NO: 141   AGATAGTTTCGTAATTCATC               SEQ ID NO: 142   CCTAACTCACACAAACCACCA               SEQ ID NO: 143   CTAACTCACAAAAACCACCAA               SEQ ID NO: 144   TAACTCACACAAACCACCAAC               SEQ ID NO: 145   AACTCACACATACCACCAACA               SEQ ID NO: 146   ACTCACACAATCCACCAACAC               SEQ ID NO: 147   CTCACACAAATCACCAACACC               SEQ ID NO: 148   TCACACAAACTACCAACACCT               SEQ ID NO: 149   CACACAAACCTCCAACACCTC               SEQ ID NO: 150   ACACAAACCATCAACACCTCT               SEQ ID NO: 151   CACAAACCACTAACACCTCTC               SEQ ID NO: 152   ACAAACCACCTACACCTCTCC               SEQ ID NO: 153   CAAACCACCATCACCTCTCCC               SEQ ID NO: 154   AAACCACCAATACCTCTCCCC               SEQ ID NO: 155   AACCACCAACTCCTCTCCCCC               SEQ ID NO: 156   ACCACCAACATCTCTCCCCCT               SEQ ID NO: 157   CCACCAACACTTCTCCCCCTC               SEQ ID NO: 158   CACCAACACCTCTCCCCCTCT               SEQ ID NO: 159   ACCAACACCTTTCCCCCTCTC               SEQ ID NO: 160   CCAACACCTCTCCCCCTCTCA               SEQ ID NO: 161   CAACACCTCTTCCCCTCTCAT               SEQ ID NO: 162   AACACCTCTCTCCCTCTCATC               SEQ ID NO: 163   ACACCTCTCCTCCTCTCATCC               SEQ ID NO: 164   CACCTCTCCCTCTCTCATCCA               SEQ ID NO: 165   ACCTCTCCCCTTCTCATCCAT               SEQ ID NO: 166   CCTCTCCCCCTCTCATCCATC               SEQ ID NO: 167   ATATAGTTTCGTCATTCATC               SEQ ID NO: 168   TACATTGCCCATGTAATTAA               SEQ ID NO: 169   ATATAGTTTCGTCATTCATC               SEQ ID NO: 170   TACATTGCCCATGTAATTAA               SEQ ID NO: 171   AGATAGTTTTGTCATTCATC               SEQ ID NO: 172   AGATAGTTTCTTCATTCATC               SEQ ID NO: 173   AGATAGTTTCGTCATTCATC               SEQ ID NO: 174   AGATAGTTTCGTTATTCATC               SEQ ID NO: 175   CTCTCCCCCTTTCATCCATCA               SEQ ID NO: 176   TCTCCCCCTCTCATCCATCAC               SEQ ID NO: 177   CTCCCCCTCTTATCCATCACC               SEQ ID NO: 178   TCCCCCTCTCTTCCATCACCC               SEQ ID NO: 179   CCCCCTCTCATCCATCACCCA               SEQ ID NO: 180   CCCCTCTCATTCATCACCCAC               SEQ ID NO: 181   AACTCACACAGACCACCAACA               SEQ ID NO: 182   ACTCACACAAGCCACCAACAC               SEQ ID NO: 183   CTCACACAAAGCACCAACACC               SEQ ID NO: 184   TCACACAAACGACCAACACCT               SEQ ID NO: 185   CACACAAACCGCCAACACCTC               SEQ ID NO: 186   ACACAAACCAGCAACACCTCT               SEQ ID NO: 187   CACAAACCACGAACACCTCTC               SEQ ID NO: 188   ACAAACCACCGACACCTCTCC               SEQ ID NO: 189   CAAACCACCAGCACCTCTCCC               SEQ ID NO: 190   AAACCACCAAGACCTCTCCCC               SEQ ID NO: 191   AACCACCAACGCCTCTCCCCC               SEQ ID NO: 192   ACCACCAACAGCTCTCCCCCT               SEQ ID NO: 193   CCACCAACACGTCTCCCCCTC               SEQ ID NO: 194   CACCAACACCGCTCCCCCTCT               SEQ ID NO: 195   ACCAACACCTGTCCCCCTCTC               SEQ ID NO: 196   CCAACACCTCGCCCCCTCTCA               SEQ ID NO: 197   CAACACCTCTGCCCCTCTCAT               SEQ ID NO: 198   AACACCTCTCGCCCTCTCATC               SEQ ID NO: 199   ACACCTCTCCGCCTCTCATCC               SEQ ID NO: 200   CACCTCTCCCGCTCTCATCCA               SEQ ID NO: 201   ACCTCTCCCCGTCTCATCCAT               SEQ ID NO: 202   CCTCTCCCCCGCTCATCCATC               SEQ ID NO: 203   TACATTGCCCATGTAATTAA               SEQ ID NO: 204   ATATAGTTTCGTCATTCATC               SEQ ID NO: 205   TACATTGCCCATGTAATTAA               SEQ ID NO: 206   ATATAGTTTCGTCATTCATC               SEQ ID NO: 207   AGATAGTTTGGTCATTCATC               SEQ ID NO: 208   AGATAGTTTCGTCATTCATC               SEQ ID NO: 209   AGATAGTTTCGGCATTCATC               SEQ ID NO: 210   AGATAGTTTCGTGATTCATC               SEQ ID NO: 211   CTCTCCCCCTGTCATCCATCA               SEQ ID NO: 212   TCTCCCCCTCGCATCCATCAC               SEQ ID NO: 213   CTCCCCCTCTGATCCATCACC               SEQ ID NO: 214   TCCCCCTCTCGTCCATCACCC               SEQ ID NO: 215   CCCCCTCTCAGCCATCACCCA               SEQ ID NO: 216   CCCCTCTCATGCATCACCCAC               SEQ ID NO: 217   AACTCACACACACCACCAACA               SEQ ID NO: 218   ACTCACACAACCCACCAACAC               SEQ ID NO: 219   CTCACACAAACCACCAACACC               SEQ ID NO: 220   TCACACAAACCACCAACACCT               SEQ ID NO: 221   CACACAAACCCCCAACACCTC               SEQ ID NO: 222   ACACAAACCACCAACACCTCT               SEQ ID NO: 223   CACAAACCACCAACACCTCTC               SEQ ID NO: 224   ACAAACCACCCACACCTCTCC               SEQ ID NO: 225   CAAACCACCACCACCTCTCCC               SEQ ID NO: 226   AAACCACCAACACCTCTCCCC               SEQ ID NO: 227   AACCACCAACCCCTCTCCCCC               SEQ ID NO: 228   ACCACCAACACCTCTCCCCCT               SEQ ID NO: 229   CCACCAACACCTCTCCCCCTC               SEQ ID NO: 230   CACCAACACCCCTCCCCCTCT               SEQ ID NO: 231   ACCAACACCTCTCCCCCTCTC               SEQ ID NO: 232   CCAACACCTCCCCCCCTCTCA               SEQ ID NO: 233   CAACACCTCTCCCCCTCTCAT               SEQ ID NO: 234   AACACCTCTCCCCCTCTCATC               SEQ ID NO: 235   ACACCTCTCCCCCTCTCATCC               SEQ ID NO: 236   CACCTCTCCCCCTCTCATCCA               SEQ ID NO: 237   ACCTCTCCCCCTCTCATCCAT               SEQ ID NO: 238   CCTCTCCCCCCCTCATCCATC               SEQ ID NO: 239   ATATAGTTTCGTCATTCATC               SEQ ID NO: 240   TACATTGCCCATGTAATTAA               SEQ ID NO: 241   ATATAGTTTCGTCATTCATC               SEQ ID NO: 242   TACATTGCCCATGTAATTAA               SEQ ID NO: 243   AGATAGTTTCGTCATTCATC               SEQ ID NO: 244   AGATAGTTTCCTCATTCATC               SEQ ID NO: 245   AGATAGTTTCGCCATTCATC               SEQ ID NO: 246   AGATAGTTTCGTCATTCATC               SEQ ID NO: 247   CTCTCCCCCTCTCATCCATCA               SEQ ID NO: 248   TCTCCCCCTCCCATCCATCAC               SEQ ID NO: 249   CTCCCCCTCTCATCCATCACC               SEQ ID NO: 250   TCCCCCTCTCCTCCATCACCC               SEQ ID NO: 251   CCCCCTCTCACCCATCACCCA               SEQ ID NO: 252   CCCCTCTCATCCATCACCCAC               SEQ ID NO: 253   AACTCACACAAACCACCAACA               SEQ ID NO: 254   ACTCACACAAACCACCAACAC               SEQ ID NO: 255   CTCACACAAAACACCAACACC               SEQ ID NO: 256   TCACACAAACAACCAACACCT               SEQ ID NO: 257   CACACAAACCACCAACACCTC               SEQ ID NO: 258   ACACAAACCAACAACACCTCT               SEQ ID NO: 259   CACAAACCACAAACACCTCTC               SEQ ID NO: 260   ACAAACCACCAACACCTCTCC               SEQ ID NO: 261   CAAACCACCAACACCTCTCCC               SEQ ID NO: 262   AAACCACCAAAACCTCTCCCC               SEQ ID NO: 263   AACCACCAACACCTCTCCCCC               SEQ ID NO: 264   ACCACCAACAACTCTCCCCCT               SEQ ID NO: 265   CCACCAACACATCTCCCCCTC               SEQ ID NO: 266   CACCAACACCACTCCCCCTCT               SEQ ID NO: 267   ACCAACACCTATCCCCCTCTC               SEQ ID NO: 268   CCAACACCTCACCCCCTCTCA               SEQ ID NO: 269   CAACACCTCTACCCCTCTCAT               SEQ ID NO: 270   AACACCTCTCACCCTCTCATC               SEQ ID NO: 271   ACACCTCTCCACCTCTCATCC               SEQ ID NO: 272   CACCTCTCCCACTCTCATCCA               SEQ ID NO: 273   ACCTCTCCCCATCTCATCCAT               SEQ ID NO: 274   CCTCTCCCCCACTCATCCATC               SEQ ID NO: 275   TACATTGCCCATGTAATTAA               SEQ ID NO: 276   ATATAGTTTCGTCATTCATC               SEQ ID NO: 277   TACATTGCCCATGTAATTAA               SEQ ID NO: 278   ATATAGTTTCGTCATTCATC               SEQ ID NO: 279   AGATAGTTTAGTCATTCATC               SEQ ID NO: 280   AGATAGTTTCATCATTCATC               SEQ ID NO: 281   AGATAGTTTCGACATTCATC               SEQ ID NO: 282   AGATAGTTTCGTAATTCATC               SEQ ID NO: 283   CTCTCCCCCTATCATCCATCA               SEQ ID NO: 284   TCTCCCCCTCACATCCATCAC               SEQ ID NO: 285   CTCCCCCTCTAATCCATCACC               SEQ ID NO: 286   TCCCCCTCTCATCCATCACCC               SEQ ID NO: 287   CCCCCTCTCAACCATCACCCA               SEQ ID NO: 288   CCCCTCTCATACATCACCCAC               SEQ ID NO: 289   CCCTCTCATCTATCACCCACC               SEQ ID NO: 290   CCTCTCATCCTTCACCCACCA               SEQ ID NO: 291   CTCTCATCCATCACCCACCAC               SEQ ID NO: 292   TCTCATCCATTACCCACCACC               SEQ ID NO: 293   CTCATCCATCTCCCACCACCC               SEQ ID NO: 294   TCATCCATCATCCACCACCCC               SEQ ID NO: 295   CATCCATCACTCACCACCCCT               SEQ ID NO: 296   ATCCATCACCTACCACCCCTC               SEQ ID NO: 297   TCCATCACCCTCCACCCCTCA               SEQ ID NO: 298   CCATCACCCATCACCCCTCAT               SEQ ID NO: 299   CATCACCCACTACCCCTCATC               SEQ ID NO: 300   ATCACCCACCTCCCCTCATCA               SEQ ID NO: 301   TCACCCACCATCCCTCATCAT               SEQ ID NO: 302   CACCCACCACTCCTCATCATA               SEQ ID NO: 303   ACCCACCACCTCTCATCATAC               SEQ ID NO: 304   CCCACCACCCTTCATCATACC               SEQ ID NO: 305   CCACCACCCCTCATCATACCT               SEQ ID NO: 306   CACCACCCCTTATCATACCTC               SEQ ID NO: 307   ACCACCCCTCTTCATACCTCA               SEQ ID NO: 308   ATATAGTTTCGTCATTCATC               SEQ ID NO: 309   TACATTGCCCATGTAATTAA               SEQ ID NO: 310   ATATAGTTTCGTCATTCATC               SEQ ID NO: 311   TACATTGCCCATGTAATTAA               SEQ ID NO: 312   AGATAGTTTTGTCATTCATC               SEQ ID NO: 313   AGATAGTTTCTTCATTCATC               SEQ ID NO: 314   AGATAGTTTCGTCATTCATC               SEQ ID NO: 315   AGATAGTTTCGTTATTCATC               SEQ ID NO: 316   CCACCCCTCATCATACCTCAA               SEQ ID NO: 317   CACCCCTCATTATACCTCAAC               SEQ ID NO: 318   ACCCCTCATCTTACCTCAACC               SEQ ID NO: 319   CCCCTCATCATACCTCAACCA               SEQ ID NO: 320   CCCTCATCATTCCTCAACCAC               SEQ ID NO: 321   CCTCATCATATCTCAACCACC               SEQ ID NO: 322   CTCATCATACTTCAACCACCA               SEQ ID NO: 323   TCATCATACCTCAACCACCAC               SEQ ID NO: 324   CATCATACCTTAACCACCACC               SEQ ID NO: 325   CCCTCTCATCGATCACCCACC               SEQ ID NO: 326   CCTCTCATCCGTCACCCACCA               SEQ ID NO: 327   CTCTCATCCAGCACCCACCAC               SEQ ID NO: 328   TCTCATCCATGACCCACCACC               SEQ ID NO: 329   CTCATCCATCGCCCACCACCC               SEQ ID NO: 330   TCATCCATCAGCCACCACCCC               SEQ ID NO: 331   CATCCATCACGCACCACCCCT               SEQ ID NO: 332   ATCCATCACCGACCACCCCTC               SEQ ID NO: 333   TCCATCACCCGCCACCCCTCA               SEQ ID NO: 334   CCATCACCCAGCACCCCTCAT               SEQ ID NO: 335   CATCACCCACGACCCCTCATC               SEQ ID NO: 336   ATCACCCACCGCCCCTCATCA               SEQ ID NO: 337   TCACCCACCAGCCCTCATCAT               SEQ ID NO: 338   CACCCACCACGCCTCATCATA               SEQ ID NO: 339   ACCCACCACCGCTCATCATAC               SEQ ID NO: 340   CCCACCACCCGTCATCATACC               SEQ ID NO: 341   CCACCACCCCGCATCATACCT               SEQ ID NO: 342   CACCACCCCTGATCATACCTC               SEQ ID NO: 343   ACCACCCCTCGTCATACCTCA               SEQ ID NO: 344   TACATTGCCCATGTAATTAA               SEQ ID NO: 345   ATATAGTTTCGTCATTCATC               SEQ ID NO: 346   TACATTGCCCATGTAATTAA               SEQ ID NO: 347   ATATAGTTTCGTCATTCATC               SEQ ID NO: 348   AGATAGTTTGGTCATTCATC               SEQ ID NO: 349   AGATAGTTTCGTCATTCATC               SEQ ID NO: 350   AGATAGTTTCGGCATTCATC               SEQ ID NO: 351   AGATAGTTTCGTGATTCATC               SEQ ID NO: 352   CCACCCCTCAGCATACCTCAA               SEQ ID NO: 353   CACCCCTCATGATACCTCAAC               SEQ ID NO: 354   ACCCCTCATCGTACCTCAACC               SEQ ID NO: 355   CCCCTCATCAGACCTCAACCA               SEQ ID NO: 356   CCCTCATCATGCCTCAACCAC               SEQ ID NO: 357   CCTCATCATAGCTCAACCACC               SEQ ID NO: 358   CTCATCATACGTCAACCACCA               SEQ ID NO: 359   TCATCATACCGCAACCACCAC               SEQ ID NO: 360   CATCATACCTGAACCACCACC               SEQ ID NO: 361   CCCTCTCATCCATCACCCACC               SEQ ID NO: 362   CCTCTCATCCCTCACCCACCA               SEQ ID NO: 363   CTCTCATCCACCACCCACCAC               SEQ ID NO: 364   TCTCATCCATCACCCACCACC               SEQ ID NO: 365   CTCATCCATCCCCCACCACCC               SEQ ID NO: 366   TCATCCATCACCCACCACCCC               SEQ ID NO: 367   CATCCATCACCCACCACCCCT               SEQ ID NO: 368   ATCCATCACCCACCACCCCTC               SEQ ID NO: 369   TCCATCACCCCCCACCCCTCA               SEQ ID NO: 370   CCATCACCCACCACCCCTCAT               SEQ ID NO: 371   CATCACCCACCACCCCTCATC               SEQ ID NO: 372   ATCACCCACCCCCCCTCATCA               SEQ ID NO: 373   TCACCCACCACCCCTCATCAT               SEQ ID NO: 374   CACCCACCACCCCTCATCATA               SEQ ID NO: 375   ACCCACCACCCCTCATCATAC               SEQ ID NO: 376   CCCACCACCCCTCATCATACC               SEQ ID NO: 377   CCACCACCCCCCATCATACCT               SEQ ID NO: 378   CACCACCCCTCATCATACCTC               SEQ ID NO: 379   ACCACCCCTCCTCATACCTCA               SEQ ID NO: 380   ATATAGTTTCGTCATTCATC               SEQ ID NO: 381   TACATTGCCCATGTAATTAA               SEQ ID NO: 382   ATATAGTTTCGTCATTCATC               SEQ ID NO: 383   TACATTGCCCATGTAATTAA               SEQ ID NO: 384   AGATAGTTTCGTCATTCATC               SEQ ID NO: 385   AGATAGTTTCCTCATTCATC               SEQ ID NO: 386   AGATAGTTTCGCCATTCATC               SEQ ID NO: 387   AGATAGTTTCGTCATTCATC               SEQ ID NO: 388   CCACCCCTCACCATACCTCAA               SEQ ID NO: 389   CACCCCTCATCATACCTCAAC               SEQ ID NO: 390   ACCCCTCATCCTACCTCAACC               SEQ ID NO: 391   CCCCTCATCACACCTCAACCA               SEQ ID NO: 392   CCCTCATCATCCCTCAACCAC               SEQ ID NO: 393   CCTCATCATACCTCAACCACC               SEQ ID NO: 394   CTCATCATACCTCAACCACCA               SEQ ID NO: 395   TCATCATACCCCAACCACCAC               SEQ ID NO: 396   CATCATACCTCAACCACCACC               SEQ ID NO: 397   CCCTCTCATCAATCACCCACC               SEQ ID NO: 398   CCTCTCATCCATCACCCACCA               SEQ ID NO: 399   CTCTCATCCAACACCCACCAC               SEQ ID NO: 400   TCTCATCCATAACCCACCACC               SEQ ID NO: 401   CTCATCCATCACCCACCACCC               SEQ ID NO: 402   TCATCCATCAACCACCACCCC               SEQ ID NO: 403   CATCCATCACACACCACCCCT               SEQ ID NO: 404   ATCCATCACCAACCACCCCTC               SEQ ID NO: 405   TCCATCACCCACCACCCCTCA               SEQ ID NO: 406   CCATCACCCAACACCCCTCAT               SEQ ID NO: 407   CATCACCCACAACCCCTCATC               SEQ ID NO: 408   ATCACCCACCACCCCTCATCA               SEQ ID NO: 409   TCACCCACCAACCCTCATCAT               SEQ ID NO: 410   CACCCACCACACCTCATCATA               SEQ ID NO: 411   ACCCACCACCACTCATCATAC               SEQ ID NO: 412   CCCACCACCCATCATCATACC               SEQ ID NO: 413   CCACCACCCCACATCATACCT               SEQ ID NO: 414   CACCACCCCTAATCATACCTC               SEQ ID NO: 415   ACCACCCCTCATCATACCTCA               SEQ ID NO: 416   TACATTGCCCATGTAATTAA               SEQ ID NO: 417   ATATAGTTTCGTCATTCATC               SEQ ID NO: 418   TACATTGCCCATGTAATTAA               SEQ ID NO: 419   ATATAGTTTCGTCATTCATC               SEQ ID NO: 420   AGATAGTTTAGTCATTCATC               SEQ ID NO: 421   AGATAGTTTCATCATTCATC               SEQ ID NO: 422   AGATAGTTTCGACATTCATC               SEQ ID NO: 423   AGATAGTTTCGTAATTCATC               SEQ ID NO: 424   CCACCCCTCAACATACCTCAA               SEQ ID NO: 425   CACCCCTCATAATACCTCAAC               SEQ ID NO: 426   ACCCCTCATCATACCTCAACC               SEQ ID NO: 427   CCCCTCATCAAACCTCAACCA               SEQ ID NO: 428   CCCTCATCATACCTCAACCAC               SEQ ID NO: 429   CCTCATCATAACTCAACCACC               SEQ ID NO: 430   CTCATCATACATCAACCACCA               SEQ ID NO: 431   TCATCATACCACAACCACCAC               SEQ ID NO: 432   CATCATACCTAAACCACCACC               SEQ ID NO: 433   ATCATACCTCTACCACCACCC               SEQ ID NO: 434   TCATACCTCATCCACCACCCC               SEQ ID NO: 435   CATACCTCAATCACCACCCCT               SEQ ID NO: 436   ATACCTCAACTACCACCCCTC               SEQ ID NO: 437   TACCTCAACCTCCACCCCTCA               SEQ ID NO: 438   ACCTCAACCATCACCCCTCAT               SEQ ID NO: 439   CCTCAACCACTACCCCTCATC               SEQ ID NO: 440   CTCAACCACCTCCCCTCATCA               SEQ ID NO: 441   TCAACCACCATCCCTCATCAT               SEQ ID NO: 442   CAACCACCACTCCTCATCATA               SEQ ID NO: 443   AACCACCACCTCTCATCATAC               SEQ ID NO: 444   ACCACCACCCTTCATCATACC               SEQ ID NO: 445   CCACCACCCCTCATCATACCT               SEQ ID NO: 446   CACCACCCCTTATCATACCTC               SEQ ID NO: 447   ACCACCCCTCTTCATACCTCA               SEQ ID NO: 448   CCACCCCTCATCATACCTCAA               SEQ ID NO: 449   ATATAGTTTCGTCATTCATC               SEQ ID NO: 450   TACATTGCCCATGTAATTAA               SEQ ID NO: 451   ATATAGTTTCGTCATTCATC               SEQ ID NO: 452   TACATTGCCCATGTAATTAA               SEQ ID NO: 453   AGATAGTTTTGTCATTCATC               SEQ ID NO: 454   AGATAGTTTCTTCATTCATC               SEQ ID NO: 455   AGATAGTTTCGTCATTCATC               SEQ ID NO: 456   AGATAGTTTCGTTATTCATC               SEQ ID NO: 457   CACCCCTCATTATACCTCAAA               SEQ ID NO: 458   ACCCCTCATCTTACCTCAAAA               SEQ ID NO: 459   CCCCTCATCATACCTCAAAAA               SEQ ID NO: 460   CCCTCATCATTCCTCAAAAAC               SEQ ID NO: 461   CCTCATCATATCTCAAAAACC               SEQ ID NO: 462   CTCATCATACTTCAAAAACCA               SEQ ID NO: 463   TCATCATACCTCAAAAACCAA               SEQ ID NO: 464   CATCATACCTTAAAAACCAAC               SEQ ID NO: 465   ATCATACCTCTAAAACCAACT               SEQ ID NO: 466   TCATACCTCATAAACCAACTA               SEQ ID NO: 467   CATACCTCAATAACCAACTAA               SEQ ID NO: 468   ATACCTCAAATACCAACTAAC               SEQ ID NO: 469   ATCATACCTCGACCACCACCC               SEQ ID NO: 470   TCATACCTCAGCCACCACCCC               SEQ ID NO: 471   CATACCTCAAGCACCACCCCT               SEQ ID NO: 472   ATACCTCAACGACCACCCCTC               SEQ ID NO: 473   TACCTCAACCGCCACCCCTCA               SEQ ID NO: 474   ACCTCAACCAGCACCCCTCAT               SEQ ID NO: 475   CCTCAACCACGACCCCTCATC               SEQ ID NO: 476   CTCAACCACCGCCCCTCATCA               SEQ ID NO: 477   TCAACCACCAGCCCTCATCAT               SEQ ID NO: 478   CAACCACCACGCCTCATCATA               SEQ ID NO: 479   AACCACCACCGCTCATCATAC               SEQ ID NO: 480   ACCACCACCCGTCATCATACC               SEQ ID NO: 481   CCACCACCCCGCATCATACCT               SEQ ID NO: 482   CACCACCCCTGATCATACCTC               SEQ ID NO: 483   ACCACCCCTCGTCATACCTCA               SEQ ID NO: 484   CCACCCCTCAGCATACCTCAA               SEQ ID NO: 485   TACATTGCCCATGTAATTAA               SEQ ID NO: 486   ATATAGTTTCGTCATTCATC               SEQ ID NO: 487   TACATTGCCCATGTAATTAA               SEQ ID NO: 488   ATATAGTTTCGTCATTCATC               SEQ ID NO: 489   AGATAGTTTGGTCATTCATC               SEQ ID NO: 490   AGATAGTTTCGTCATTCATC               SEQ ID NO: 491   AGATAGTTTCGGCATTCATC               SEQ ID NO: 492   AGATAGTTTCGTGATTCATC               SEQ ID NO: 493   CACCCCTCATGATACCTCAAA               SEQ ID NO: 494   ACCCCTCATCGTACCTCAAAA               SEQ ID NO: 495   CCCCTCATCAGACCTCAAAAA               SEQ ID NO: 496   CCCTCATCATGCCTCAAAAAC               SEQ ID NO: 497   CCTCATCATAGCTCAAAAACC               SEQ ID NO: 498   CTCATCATACGTCAAAAACCA               SEQ ID NO: 499   TCATCATACCGCAAAAACCAA               SEQ ID NO: 500   CATCATACCTGAAAAACCAAC               SEQ ID NO: 501   ATCATACCTCGAAAACCAACT               SEQ ID NO: 502   TCATACCTCAGAAACCAACTA               SEQ ID NO: 503   CATACCTCAAGAACCAACTAA               SEQ ID NO: 504   ATACCTCAAAGACCAACTAAC               SEQ ID NO: 505   ATCATACCTCCACCACCACCC               SEQ ID NO: 506   TCATACCTCACCCACCACCCC               SEQ ID NO: 507   CATACCTCAACCACCACCCCT               SEQ ID NO: 508   ATACCTCAACCACCACCCCTC               SEQ ID NO: 509   TACCTCAACCCCCACCCCTCA               SEQ ID NO: 510   ACCTCAACCACCACCCCTCAT               SEQ ID NO: 511   CCTCAACCACCACCCCTCATC               SEQ ID NO: 512   CTCAACCACCCCCCCTCATCA               SEQ ID NO: 513   TCAACCACCACCCCTCATCAT               SEQ ID NO: 514   CAACCACCACCCCTCATCATA               SEQ ID NO: 515   AACCACCACCCCTCATCATAC               SEQ ID NO: 516   ACCACCACCCCTCATCATACC               SEQ ID NO: 517   CCACCACCCCCCATCATACCT               SEQ ID NO: 518   CACCACCCCTCATCATACCTC               SEQ ID NO: 519   ACCACCCCTCCTCATACCTCA               SEQ ID NO: 520   CCACCCCTCACCATACCTCAA               SEQ ID NO: 521   ATATAGTTTCGTCATTCATC               SEQ ID NO: 522   TACATTGCCCATGTAATTAA               SEQ ID NO: 523   ATATAGTTTCGTCATTCATC               SEQ ID NO: 524   TACATTGCCCATGTAATTAA               SEQ ID NO: 525   AGATAGTTTCGTCATTCATC               SEQ ID NO: 526   AGATAGTTTCCTCATTCATC               SEQ ID NO: 527   AGATAGTTTCGCCATTCATC               SEQ ID NO: 528   AGATAGTTTCGTCATTCATC               SEQ ID NO: 529   CACCCCTCATCATACCTCAAA               SEQ ID NO: 530   ACCCCTCATCCTACCTCAAAA               SEQ ID NO: 531   CCCCTCATCACACCTCAAAAA               SEQ ID NO: 532   CCCTCATCATCCCTCAAAAAC               SEQ ID NO: 533   CCTCATCATACCTCAAAAACC               SEQ ID NO: 534   CTCATCATACCTCAAAAACCA               SEQ ID NO: 535   TCATCATACCCCAAAAACCAA               SEQ ID NO: 536   CATCATACCTCAAAAACCAAC               SEQ ID NO: 537   ATCATACCTCCAAAACCAACT               SEQ ID NO: 538   TCATACCTCACAAACCAACTA               SEQ ID NO: 539   CATACCTCAACAACCAACTAA               SEQ ID NO: 540   ATACCTCAAACACCAACTAAC               SEQ ID NO: 541   ATCATACCTCAACCACCACCC               SEQ ID NO: 542   TCATACCTCAACCACCACCCC               SEQ ID NO: 543   CATACCTCAAACACCACCCCT               SEQ ID NO: 544   ATACCTCAACAACCACCCCTC               SEQ ID NO: 545   TACCTCAACCACCACCCCTCA               SEQ ID NO: 546   ACCTCAACCAACACCCCTCAT               SEQ ID NO: 547   CCTCAACCACAACCCCTCATC               SEQ ID NO: 548   CTCAACCACCACCCCTCATCA               SEQ ID NO: 549   TCAACCACCAACCCTCATCAT               SEQ ID NO: 550   CAACCACCACACCTCATCATA               SEQ ID NO: 551   AACCACCACCACTCATCATAC               SEQ ID NO: 552   ACCACCACCCATCATCATACC               SEQ ID NO: 553   CCACCACCCCACATCATACCT               SEQ ID NO: 554   CACCACCCCTAATCATACCTC               SEQ ID NO: 555   ACCACCCCTCATCATACCTCA               SEQ ID NO: 556   CCACCCCTCAACATACCTCAA               SEQ ID NO: 557   TACATTGCCCATGTAATTAA               SEQ ID NO: 558   ATATAGTTTCGTCATTCATC               SEQ ID NO: 559   TACATTGCCCATGTAATTAA               SEQ ID NO: 560   ATATAGTTTCGTCATTCATC               SEQ ID NO: 561   AGATAGTTTAGTCATTCATC               SEQ ID NO: 562   AGATAGTTTCATCATTCATC               SEQ ID NO: 563   AGATAGTTTCGACATTCATC               SEQ ID NO: 564   AGATAGTTTCGTAATTCATC               SEQ ID NO: 565   CACCCCTCATAATACCTCAAA               SEQ ID NO: 566   ACCCCTCATCATACCTCAAAA               SEQ ID NO: 567   CCCCTCATCAAACCTCAAAAA               SEQ ID NO: 568   CCCTCATCATACCTCAAAAAC               SEQ ID NO: 569   CCTCATCATAACTCAAAAACC               SEQ ID NO: 570   CTCATCATACATCAAAAACCA               SEQ ID NO: 571   TCATCATACCACAAAAACCAA               SEQ ID NO: 572   CATCATACCTAAAAAACCAAC               SEQ ID NO: 573   ATCATACCTCAAAAACCAACT               SEQ ID NO: 574   TCATACCTCAAAAACCAACTA               SEQ ID NO: 575   CATACCTCAAAAACCAACTAA               SEQ ID NO: 576   ATACCTCAAAAACCAACTAAC               SEQ ID NO: 577   TACCTCAAAATCCAACTAACC               SEQ ID NO: 578   ACCTCAAAAATCAACTAACCA               SEQ ID NO: 579   CCTCAAAAACTAACTAACCAA               SEQ ID NO: 580   CTCAAAAACCTACTAACCAAC               SEQ ID NO: 581   TCAAAAACCATCTAACCAACC               SEQ ID NO: 582   CAAAAACCAATTAACCAACCA               SEQ ID NO: 583   AAAAACCAACTAACCAACCAA               SEQ ID NO: 584   AAAACCAACTTACCAACCAAT               SEQ ID NO: 585   AACCAACCAATAATCTCCCAC               SEQ ID NO: 586   ACCAACCAATTATCTCCCACC               SEQ ID NO: 587   CCAACCAATATTCTCCCACCC               SEQ ID NO: 588   CAACCAATAATCTCCCACCCC               SEQ ID NO: 589   AACCAATAATTTCCCACCCCG               SEQ ID NO: 590   ATATAGTTTCGTCATTCATC               SEQ ID NO: 591   TACATTGCCCATGTAATTAA               SEQ ID NO: 592   ATATAGTTTCGTCATTCATC               SEQ ID NO: 593   TACATTGCCCATGTAATTAA               SEQ ID NO: 594   AGATAGTTTTGTCATTCATC               SEQ ID NO: 595   AGATAGTTTCTTCATTCATC               SEQ ID NO: 596   AGATAGTTTCGTCATTCATC               SEQ ID NO: 597   AGATAGTTTCGTTATTCATC               SEQ ID NO: 598   ACCAATAATCTCCCACCCCGC               SEQ ID NO: 599   CCAATAATCTTCCACCCCGCC               SEQ ID NO: 600   CAATAATCTCTCACCCCGCCT               SEQ ID NO: 601   AATAATCTCCTACCCCGCCTA               SEQ ID NO: 602   ATAATCTCCCTCCCCGCCTAG               SEQ ID NO: 603   TAATCTCCCATCCCGCCTAGC               SEQ ID NO: 604   AATCTCCCACTCCGCCTAGCT               SEQ ID NO: 605   ATCTCCCACCTCGCCTAGCTC               SEQ ID NO: 606   TCTCCCACCCTGCCTAGCTCA               SEQ ID NO: 607   CTCCCACCCCTCCTAGCTCAC               SEQ ID NO: 608   TCCCACCCCGTCTAGCTCACG               SEQ ID NO: 609   CCCACCCCGCTTAGCTCACGC               SEQ ID NO: 610   CCACCCCGCCTAGCTCACGCA               SEQ ID NO: 611   CACCCCGCCTTGCTCACGCAA               SEQ ID NO: 612   ACCCCGCCTATCTCACGCAAG               SEQ ID NO: 613   TACCTCAAAAGCCAACTAACC               SEQ ID NO: 614   ACCTCAAAAAGCAACTAACCA               SEQ ID NO: 615   CCTCAAAAACGAACTAACCAA               SEQ ID NO: 616   CTCAAAAACCGACTAACCAAC               SEQ ID NO: 617   TCAAAAACCAGCTAACCAACC               SEQ ID NO: 618   CAAAAACCAAGTAACCAACCA               SEQ ID NO: 619   AAAAACCAACGAACCAACCAA               SEQ ID NO: 620   AAAACCAACTGACCAACCAAT               SEQ ID NO: 621   AACCAACCAAGAATCTCCCAC               SEQ ID NO: 622   ACCAACCAATGATCTCCCACC               SEQ ID NO: 623   CCAACCAATAGTCTCCCACCC               SEQ ID NO: 624   CAACCAATAAGCTCCCACCCC               SEQ ID NO: 625   AACCAATAATGTCCCACCCCG               SEQ ID NO: 626   TACATTGCCCATGTAATTAA               SEQ ID NO: 627   ATATAGTTTCGTCATTCATC               SEQ ID NO: 628   TACATTGCCCATGTAATTAA               SEQ ID NO: 629   ATATAGTTTCGTCATTCATC               SEQ ID NO: 630   AGATAGTTTGGTCATTCATC               SEQ ID NO: 631   AGATAGTTTCGTCATTCATC               SEQ ID NO: 632   AGATAGTTTCGGCATTCATC               SEQ ID NO: 633   AGATAGTTTCGTGATTCATC               SEQ ID NO: 634   ACCAATAATCGCCCACCCCGC               SEQ ID NO: 635   CCAATAATCTGCCACCCCGCC               SEQ ID NO: 636   CAATAATCTCGCACCCCGCCT               SEQ ID NO: 637   AATAATCTCCGACCCCGCCTA               SEQ ID NO: 638   ATAATCTCCCGCCCCGCCTAG               SEQ ID NO: 639   TAATCTCCCAGCCCGCCTAGC               SEQ ID NO: 640   AATCTCCCACGCCGCCTAGCT               SEQ ID NO: 641   ATCTCCCACCGCGCCTAGCTC               SEQ ID NO: 642   TCTCCCACCCGGCCTAGCTCA               SEQ ID NO: 643   CTCCCACCCCGCCTAGCTCAC               SEQ ID NO: 644   TCCCACCCCGGCTAGCTCACG               SEQ ID NO: 645   CCCACCCCGCGTAGCTCACGC               SEQ ID NO: 646   CCACCCCGCCGAGCTCACGCA               SEQ ID NO: 647   CACCCCGCCTGGCTCACGCAA               SEQ ID NO: 648   ACCCCGCCTAGCTCACGCAAG               SEQ ID NO: 649   TACCTCAAAACCCAACTAACC               SEQ ID NO: 650   ACCTCAAAAACCAACTAACCA               SEQ ID NO: 651   CCTCAAAAACCAACTAACCAA               SEQ ID NO: 652   CTCAAAAACCCACTAACCAAC               SEQ ID NO: 653   TCAAAAACCACCTAACCAACC               SEQ ID NO: 654   CAAAAACCAACTAACCAACCA               SEQ ID NO: 655   AAAAACCAACCAACCAACCAA               SEQ ID NO: 656   AAAACCAACTCACCAACCAAT               SEQ ID NO: 657   AACCAACCAACAATCTCCCAC               SEQ ID NO: 658   ACCAACCAATCATCTCCCACC               SEQ ID NO: 659   CCAACCAATACTCTCCCACCC               SEQ ID NO: 660   CAACCAATAACCTCCCACCCC               SEQ ID NO: 661   AACCAATAATCTCCCACCCCG               SEQ ID NO: 662   ATATAGTTTCGTCATTCATC               SEQ ID NO: 663   TACATTGCCCATGTAATTAA               SEQ ID NO: 664   ATATAGTTTCGTCATTCATC               SEQ ID NO: 665   TACATTGCCCATGTAATTAA               SEQ ID NO: 666   AGATAGTTTCGTCATTCATC               SEQ ID NO: 667   AGATAGTTTCCTCATTCATC               SEQ ID NO: 668   AGATAGTTTCGCCATTCATC               SEQ ID NO: 669   AGATAGTTTCGTCATTCATC               SEQ ID NO: 670   ACCAATAATCCCCCACCCCGC               SEQ ID NO: 671   CCAATAATCTCCCACCCCGCC               SEQ ID NO: 672   CAATAATCTCCCACCCCGCCT               SEQ ID NO: 673   AATAATCTCCCACCCCGCCTA               SEQ ID NO: 674   ATAATCTCCCCCCCCGCCTAG               SEQ ID NO: 675   TAATCTCCCACCCCGCCTAGC               SEQ ID NO: 676   AATCTCCCACCCCGCCTAGCT               SEQ ID NO: 677   ATCTCCCACCCCGCCTAGCTC               SEQ ID NO: 678   TCTCCCACCCCGCCTAGCTCA               SEQ ID NO: 679   CTCCCACCCCCCCTAGCTCAC               SEQ ID NO: 680   TCCCACCCCGCCTAGCTCACG               SEQ ID NO: 681   CCCACCCCGCCTAGCTCACGC               SEQ ID NO: 682   CCACCCCGCCCAGCTCACGCA               SEQ ID NO: 683   CACCCCGCCTCGCTCACGCAA               SEQ ID NO: 684   ACCCCGCCTACCTCACGCAAG               SEQ ID NO: 685   TACCTCAAAAACCAACTAACC               SEQ ID NO: 686   ACCTCAAAAAACAACTAACCA               SEQ ID NO: 687   CCTCAAAAACAAACTAACCAA               SEQ ID NO: 688   CTCAAAAACCAACTAACCAAC               SEQ ID NO: 689   TCAAAAACCAACTAACCAACC               SEQ ID NO: 690   CAAAAACCAAATAACCAACCA               SEQ ID NO: 691   AAAAACCAACAAACCAACCAA               SEQ ID NO: 692   AAAACCAACTAACCAACCAAT               SEQ ID NO: 693   AACCAACCAAAAATCTCCCAC               SEQ ID NO: 694   ACCAACCAATAATCTCCCACC               SEQ ID NO: 695   CCAACCAATAATCTCCCACCC               SEQ ID NO: 696   CAACCAATAAACTCCCACCCC               SEQ ID NO: 697   AACCAATAATATCCCACCCCG               SEQ ID NO: 698   TACATTGCCCATGTAATTAA               SEQ ID NO: 699   ATATAGTTTCGTCATTCATC               SEQ ID NO: 700   TACATTGCCCATGTAATTAA               SEQ ID NO: 701   ATATAGTTTCGTCATTCATC               SEQ ID NO: 702   AGATAGTTTAGTCATTCATC               SEQ ID NO: 703   AGATAGTTTCATCATTCATC               SEQ ID NO: 704   AGATAGTTTCGACATTCATC               SEQ ID NO: 705   AGATAGTTTCGTAATTCATC               SEQ ID NO: 706   ACCAATAATCACCCACCCCGC               SEQ ID NO: 707   CCAATAATCTACCACCCCGCC               SEQ ID NO: 708   CAATAATCTCACACCCCGCCT               SEQ ID NO: 709   AATAATCTCCAACCCCGCCTA               SEQ ID NO: 710   ATAATCTCCCACCCCGCCTAG               SEQ ID NO: 711   TAATCTCCCAACCCGCCTAGC               SEQ ID NO: 712   AATCTCCCACACCGCCTAGCT               SEQ ID NO: 713   ATCTCCCACCACGCCTAGCTC               SEQ ID NO: 714   TCTCCCACCCAGCCTAGCTCA               SEQ ID NO: 715   CTCCCACCCCACCTAGCTCAC               SEQ ID NO: 716   TCCCACCCCGACTAGCTCACG               SEQ ID NO: 717   CCCACCCCGCATAGCTCACGC               SEQ ID NO: 718   CCACCCCGCCAAGCTCACGCA               SEQ ID NO: 719   CACCCCGCCTAGCTCACGCAA               SEQ ID NO: 720   ACCCCGCCTAACTCACGCAAG               SEQ ID NO: 721   CCCCGCCTAGTTCACGCAAGC               SEQ ID NO: 722   CCCGCCTAGCTCACGCAAGCC               SEQ ID NO: 723   CCGCCTAGCTTACGCAAGCCG               SEQ ID NO: 724   CGCCTAGCTCTCGCAAGCCGC               SEQ ID NO: 725   GCCTAGCTCATGCAAGCCGCC               SEQ ID NO: 726   CCTAGCTCACTCAAGCCGCCA               SEQ ID NO: 727   CTAGCTCACGTAAGCCGCCAA               SEQ ID NO: 728   TAGCTCACGCTAGCCGCCAAC               SEQ ID NO: 729   AGCTCACGCATGCCGCCAACG               SEQ ID NO: 730   GCTCACGCAATCCGCCAACGC               SEQ ID NO: 731   ATATAGTTTCGTCATTCATC               SEQ ID NO: 732   TACATTGCCCATGTAATTAA               SEQ ID NO: 733   ATATAGTTTCGTCATTCATC               SEQ ID NO: 734   TACATTGCCCATGTAATTAA               SEQ ID NO: 735   AGATAGTTTTGTCATTCATC               SEQ ID NO: 736   AGATAGTTTCTTCATTCATC               SEQ ID NO: 737   AGATAGTTTCGTCATTCATC               SEQ ID NO: 738   AGATAGTTTCGTTATTCATC               SEQ ID NO: 739   CTCACGCAAGTCGCCAACGCC               SEQ ID NO: 740   TCACGCAAGCTGCCAACGCCT               SEQ ID NO: 741   CACGCAAGCCTCCAACGCCTC               SEQ ID NO: 742   ACGCAAGCCGTCAACGCCTCT               SEQ ID NO: 743   CGCAAGCCGCTAACGCCTCTC               SEQ ID NO: 744   GCAAGCCGCCTACGCCTCTCC               SEQ ID NO: 745   CAAGCCGCCATCGCCTCTCCC               SEQ ID NO: 746   AAGCCGCCAATGCCTCTCCCC               SEQ ID NO: 747   AGCCGCCAACTCCTCTCCCCC               SEQ ID NO: 748   GCCGCCAACGTCTCTCCCCCT               SEQ ID NO: 749   CCGCCAACGCTTCTCCCCCTC               SEQ ID NO: 750   CGCCAACGCCTCTCCCCCTCT               SEQ ID NO: 751   GCCAACGCCTTTCCCCCTCTC               SEQ ID NO: 752   CCAACGCCTCTCCCCCTCTCA               SEQ ID NO: 753   CAACGCCTCTTCCCCTCTCAT               SEQ ID NO: 754   AACGCCTCTCTCCCTCTCATC               SEQ ID NO: 755   ACGCCTCTCCTCCTCTCATCC               SEQ ID NO: 756   CGCCTCTCCCTCTCTCATCCA               SEQ ID NO: 757   CCCCGCCTAGGTCACGCAAGC               SEQ ID NO: 758   CCCGCCTAGCGCACGCAAGCC               SEQ ID NO: 759   CCGCCTAGCTGACGCAAGCCG               SEQ ID NO: 760   CGCCTAGCTCGCGCAAGCCGC               SEQ ID NO: 761   GCCTAGCTCAGGCAAGCCGCC               SEQ ID NO: 762   CCTAGCTCACGCAAGCCGCCA               SEQ ID NO: 763   CTAGCTCACGGAAGCCGCCAA               SEQ ID NO: 764   TAGCTCACGCGAGCCGCCAAC               SEQ ID NO: 765   AGCTCACGCAGGCCGCCAACG               SEQ ID NO: 766   GCTCACGCAAGCCGCCAACGC               SEQ ID NO: 767   TACATTGCCCATGTAATTAA               SEQ ID NO: 768   ATATAGTTTCGTCATTCATC               SEQ ID NO: 769   TACATTGCCCATGTAATTAA               SEQ ID NO: 770   ATATAGTTTCGTCATTCATC               SEQ ID NO: 771   AGATAGTTTGGTCATTCATC               SEQ ID NO: 772   AGATAGTTTCGTCATTCATC               SEQ ID NO: 773   AGATAGTTTCGGCATTCATC               SEQ ID NO: 774   AGATAGTTTCGTGATTCATC               SEQ ID NO: 775   CTCACGCAAGGCGCCAACGCC               SEQ ID NO: 776   TCACGCAAGCGGCCAACGCCT               SEQ ID NO: 777   CACGCAAGCCGCCAACGCCTC               SEQ ID NO: 778   ACGCAAGCCGGCAACGCCTCT               SEQ ID NO: 779   CGCAAGCCGCGAACGCCTCTC               SEQ ID NO: 780   GCAAGCCGCCGACGCCTCTCC               SEQ ID NO: 781   CAAGCCGCCAGCGCCTCTCCC               SEQ ID NO: 782   AAGCCGCCAAGGCCTCTCCCC               SEQ ID NO: 783   AGCCGCCAACGCCTCTCCCCC               SEQ ID NO: 784   GCCGCCAACGGCTCTCCCCCT               SEQ ID NO: 785   CCGCCAACGCGTCTCCCCCTC               SEQ ID NO: 786   CGCCAACGCCGCTCCCCCTCT               SEQ ID NO: 787   GCCAACGCCTGTCCCCCTCTC               SEQ ID NO: 788   CCAACGCCTCGCCCCCTCTCA               SEQ ID NO: 789   CAACGCCTCTGCCCCTCTCAT               SEQ ID NO: 790   AACGCCTCTCGCCCTCTCATC               SEQ ID NO: 791   ACGCCTCTCCGCCTCTCATCC               SEQ ID NO: 792   CGCCTCTCCCGCTCTCATCCA               SEQ ID NO: 793   CCCCGCCTAGCTCACGCAAGC               SEQ ID NO: 794   CCCGCCTAGCCCACGCAAGCC               SEQ ID NO: 795   CCGCCTAGCTCACGCAAGCCG               SEQ ID NO: 796   CGCCTAGCTCCCGCAAGCCGC               SEQ ID NO: 797   GCCTAGCTCACGCAAGCCGCC               SEQ ID NO: 798   CCTAGCTCACCCAAGCCGCCA               SEQ ID NO: 799   CTAGCTCACGCAAGCCGCCAA               SEQ ID NO: 800   TAGCTCACGCCAGCCGCCAAC               SEQ ID NO: 801   AGCTCACGCACGCCGCCAACG               SEQ ID NO: 802   GCTCACGCAACCCGCCAACGC               SEQ ID NO: 803   ATATAGTTTCGTCATTCATC               SEQ ID NO: 804   TACATTGCCCATGTAATTAA               SEQ ID NO: 805   ATATAGTTTCGTCATTCATC               SEQ ID NO: 806   TACATTGCCCATGTAATTAA               SEQ ID NO: 807   AGATAGTTTCGTCATTCATC               SEQ ID NO: 808   AGATAGTTTCCTCATTCATC               SEQ ID NO: 809   AGATAGTTTCGCCATTCATC               SEQ ID NO: 810   AGATAGTTTCGTCATTCATC               SEQ ID NO: 811   CTCACGCAAGCCGCCAACGCC               SEQ ID NO: 812   TCACGCAAGCCGCCAACGCCT               SEQ ID NO: 813   CACGCAAGCCCCCAACGCCTC               SEQ ID NO: 814   ACGCAAGCCGCCAACGCCTCT               SEQ ID NO: 815   CGCAAGCCGCCAACGCCTCTC               SEQ ID NO: 816   GCAAGCCGCCCACGCCTCTCC               SEQ ID NO: 817   CAAGCCGCCACCGCCTCTCCC               SEQ ID NO: 818   AAGCCGCCAACGCCTCTCCCC               SEQ ID NO: 819   AGCCGCCAACCCCTCTCCCCC               SEQ ID NO: 820   GCCGCCAACGCCTCTCCCCCT               SEQ ID NO: 821   CCGCCAACGCCTCTCCCCCTC               SEQ ID NO: 822   CGCCAACGCCCCTCCCCCTCT               SEQ ID NO: 823   GCCAACGCCTCTCCCCCTCTC               SEQ ID NO: 824   CCAACGCCTCCCCCCCTCTCA               SEQ ID NO: 825   CAACGCCTCTCCCCCTCTCAT               SEQ ID NO: 826   AACGCCTCTCCCCCTCTCATC               SEQ ID NO: 827   ACGCCTCTCCCCCTCTCATCC               SEQ ID NO: 828   CGCCTCTCCCCCTCTCATCCA               SEQ ID NO: 829   CCCCGCCTAGATCACGCAAGC               SEQ ID NO: 830   CCCGCCTAGCACACGCAAGCC               SEQ ID NO: 831   CCGCCTAGCTAACGCAAGCCG               SEQ ID NO: 832   CGCCTAGCTCACGCAAGCCGC               SEQ ID NO: 833   GCCTAGCTCAAGCAAGCCGCC               SEQ ID NO: 834   CCTAGCTCACACAAGCCGCCA               SEQ ID NO: 835   CTAGCTCACGAAAGCCGCCAA               SEQ ID NO: 836   TAGCTCACGCAAGCCGCCAAC               SEQ ID NO: 837   AGCTCACGCAAGCCGCCAACG               SEQ ID NO: 838   GCTCACGCAAACCGCCAACGC               SEQ ID NO: 839   TACATTGCCCATGTAATTAA               SEQ ID NO: 840   ATATAGTTTCGTCATTCATC               SEQ ID NO: 841   TACATTGCCCATGTAATTAA               SEQ ID NO: 842   ATATAGTTTCGTCATTCATC               SEQ ID NO: 843   AGATAGTTTAGTCATTCATC               SEQ ID NO: 844   AGATAGTTTCATCATTCATC               SEQ ID NO: 845   AGATAGTTTCGACATTCATC               SEQ ID NO: 846   AGATAGTTTCGTAATTCATC               SEQ ID NO: 847   CTCACGCAAGACGCCAACGCC               SEQ ID NO: 848   TCACGCAAGCAGCCAACGCCT               SEQ ID NO: 849   CACGCAAGCCACCAACGCCTC               SEQ ID NO: 850   ACGCAAGCCGACAACGCCTCT               SEQ ID NO: 851   CGCAAGCCGCAAACGCCTCTC               SEQ ID NO: 852   GCAAGCCGCCAACGCCTCTCC               SEQ ID NO: 853   CAAGCCGCCAACGCCTCTCCC               SEQ ID NO: 854   AAGCCGCCAAAGCCTCTCCCC               SEQ ID NO: 855   AGCCGCCAACACCTCTCCCCC               SEQ ID NO: 856   GCCGCCAACGACTCTCCCCCT               SEQ ID NO: 857   CCGCCAACGCATCTCCCCCTC               SEQ ID NO: 858   CGCCAACGCCACTCCCCCTCT               SEQ ID NO: 859   GCCAACGCCTATCCCCCTCTC               SEQ ID NO: 860   CCAACGCCTCACCCCCTCTCA               SEQ ID NO: 861   CAACGCCTCTACCCCTCTCAT               SEQ ID NO: 862   AACGCCTCTCACCCTCTCATC               SEQ ID NO: 863   ACGCCTCTCCACCTCTCATCC               SEQ ID NO: 864   CGCCTCTCCCACTCTCATCCA               SEQ ID NO: 865   GCCTCTCCCCTTCTCATCCAT               SEQ ID NO: 866   CCTCTCCCCCTCTCATCCATC               SEQ ID NO: 867   CTCTCCCCCTTTCATCCATCG               SEQ ID NO: 868   TCTCCCCCTCTCATCCATCGC               SEQ ID NO: 869   CTCCCCCTCTTATCCATCGCC               SEQ ID NO: 870   TCCCCCTCTCTTCCATCGCCC               SEQ ID NO: 871   CCCCCTCTCATCCATCGCCCG               SEQ ID NO: 872   ATATAGTTTCGTCATTCATC               SEQ ID NO: 873   TACATTGCCCATGTAATTAA               SEQ ID NO: 874   ATATAGTTTCGTCATTCATC               SEQ ID NO: 875   TACATTGCCCATGTAATTAA               SEQ ID NO: 876   AGATAGTTTTGTCATTCATC               SEQ ID NO: 877   AGATAGTTTCTTCATTCATC               SEQ ID NO: 878   AGATAGTTTCGTCATTCATC               SEQ ID NO: 879   AGATAGTTTCGTTATTCATC               SEQ ID NO: 880   CCCCTCTCATTCATCGCCCGC               SEQ ID NO: 881   CCCTCTCATCTATCGCCCGCC               SEQ ID NO: 882   CCTCTCATCCTTCGCCCGCCG               SEQ ID NO: 883   CTCTCATCCATCGCCCGCCGC               SEQ ID NO: 884   TCTCATCCATTGCCCGCCGCC               SEQ ID NO: 885   CTCATCCATCTCCCGCCGCCC               SEQ ID NO: 886   TCATCCATCGTCCGCCGCCCC               SEQ ID NO: 887   CATCCATCGCTCGCCGCCCCT               SEQ ID NO: 888   ATCCATCGCCTGCCGCCCCTC               SEQ ID NO: 889   TCCATCGCCCTCCGCCCCTCA               SEQ ID NO: 890   CCATCGCCCGTCGCCCCTCAT               SEQ ID NO: 891   CATCGCCCGCTGCCCCTCATC               SEQ ID NO: 892   ATCGCCCGCCTCCCCTCATCA               SEQ ID NO: 893   TCGCCCGCCGTCCCTCATCAT               SEQ ID NO: 894   CGCCCGCCGCTCCTCATCATA               SEQ ID NO: 895   GCCCGCCGCCTCTCATCATAC               SEQ ID NO: 896   CCCGCCGCCCTTCATCATACC               SEQ ID NO: 897   CCGCCGCCCCTCATCATACCT               SEQ ID NO: 898   CGCCGCCCCTTATCATACCTC               SEQ ID NO: 899   GCCGCCCCTCTTCATACCTCA               SEQ ID NO: 900   CCGCCCCTCATCATACCTCAG               SEQ ID NO: 901   GCCTCTCCCCGTCTCATCCAT               SEQ ID NO: 902   CCTCTCCCCCGCTCATCCATC               SEQ ID NO: 903   CTCTCCCCCTGTCATCCATCG               SEQ ID NO: 904   TCTCCCCCTCGCATCCATCGC               SEQ ID NO: 905   CTCCCCCTCTGATCCATCGCC               SEQ ID NO: 906   TCCCCCTCTCGTCCATCGCCC               SEQ ID NO: 907   CCCCCTCTCAGCCATCGCCCG               SEQ ID NO: 908   TACATTGCCCATGTAATTAA               SEQ ID NO: 909   ATATAGTTTCGTCATTCATC               SEQ ID NO: 910   TACATTGCCCATGTAATTAA               SEQ ID NO: 911   ATATAGTTTCGTCATTCATC               SEQ ID NO: 912   AGATAGTTTGGTCATTCATC               SEQ ID NO: 913   AGATAGTTTCGTCATTCATC               SEQ ID NO: 914   AGATAGTTTCGGCATTCATC               SEQ ID NO: 915   AGATAGTTTCGTGATTCATC               SEQ ID NO: 916   CCCCTCTCATGCATCGCCCGC               SEQ ID NO: 917   CCCTCTCATCGATCGCCCGCC               SEQ ID NO: 918   CCTCTCATCCGTCGCCCGCCG               SEQ ID NO: 919   CTCTCATCCAGCGCCCGCCGC               SEQ ID NO: 920   TCTCATCCATGGCCCGCCGCC               SEQ ID NO: 921   CTCATCCATCGCCCGCCGCCC               SEQ ID NO: 922   TCATCCATCGGCCGCCGCCCC               SEQ ID NO: 923   CATCCATCGCGCGCCGCCCCT               SEQ ID NO: 924   ATCCATCGCCGGCCGCCCCTC               SEQ ID NO: 925   TCCATCGCCCGCCGCCCCTCA               SEQ ID NO: 926   CCATCGCCCGGCGCCCCTCAT               SEQ ID NO: 927   CATCGCCCGCGGCCCCTCATC               SEQ ID NO: 928   ATCGCCCGCCGCCCCTCATCA               SEQ ID NO: 929   TCGCCCGCCGGCCCTCATCAT               SEQ ID NO: 930   CGCCCGCCGCGCCTCATCATA               SEQ ID NO: 931   GCCCGCCGCCGCTCATCATAC               SEQ ID NO: 932   CCCGCCGCCCGTCATCATACC               SEQ ID NO: 933   CCGCCGCCCCGCATCATACCT               SEQ ID NO: 934   CGCCGCCCCTGATCATACCTC               SEQ ID NO: 935   GCCGCCCCTCGTCATACCTCA               SEQ ID NO: 936   CCGCCCCTCAGCATACCTCAG               SEQ ID NO: 937   GCCTCTCCCCCTCTCATCCAT               SEQ ID NO: 938   CCTCTCCCCCCCTCATCCATC               SEQ ID NO: 939   CTCTCCCCCTCTCATCCATCG               SEQ ID NO: 940   TCTCCCCCTCCCATCCATCGC               SEQ ID NO: 941   CTCCCCCTCTCATCCATCGCC               SEQ ID NO: 942   TCCCCCTCTCCTCCATCGCCC               SEQ ID NO: 943   CCCCCTCTCACCCATCGCCCG               SEQ ID NO: 944   ATATAGTTTCGTCATTCATC               SEQ ID NO: 945   TACATTGCCCATGTAATTAA               SEQ ID NO: 946   ATATAGTTTCGTCATTCATC               SEQ ID NO: 947   TACATTGCCCATGTAATTAA               SEQ ID NO: 948   AGATAGTTTCGTCATTCATC               SEQ ID NO: 949   AGATAGTTTCCTCATTCATC               SEQ ID NO: 950   AGATAGTTTCGCCATTCATC               SEQ ID NO: 951   AGATAGTTTCGTCATTCATC               SEQ ID NO: 952   CCCCTCTCATCCATCGCCCGC               SEQ ID NO: 953   CCCTCTCATCCATCGCCCGCC               SEQ ID NO: 954   CCTCTCATCCCTCGCCCGCCG               SEQ ID NO: 955   CTCTCATCCACCGCCCGCCGC               SEQ ID NO: 956   TCTCATCCATCGCCCGCCGCC               SEQ ID NO: 957   CTCATCCATCCCCCGCCGCCC               SEQ ID NO: 958   TCATCCATCGCCCGCCGCCCC               SEQ ID NO: 959   CATCCATCGCCCGCCGCCCCT               SEQ ID NO: 960   ATCCATCGCCCGCCGCCCCTC               SEQ ID NO: 961   TCCATCGCCCCCCGCCCCTCA               SEQ ID NO: 962   CCATCGCCCGCCGCCCCTCAT               SEQ ID NO: 963   CATCGCCCGCCGCCCCTCATC               SEQ ID NO: 964   ATCGCCCGCCCCCCCTCATCA               SEQ ID NO: 965   TCGCCCGCCGCCCCTCATCAT               SEQ ID NO: 966   CGCCCGCCGCCCCTCATCATA               SEQ ID NO: 967   GCCCGCCGCCCCTCATCATAC               SEQ ID NO: 968   CCCGCCGCCCCTCATCATACC               SEQ ID NO: 969   CCGCCGCCCCCCATCATACCT               SEQ ID NO: 970   CGCCGCCCCTCATCATACCTC               SEQ ID NO: 971   GCCGCCCCTCCTCATACCTCA               SEQ ID NO: 972   CCGCCCCTCACCATACCTCAG               SEQ ID NO: 973   GCCTCTCCCCATCTCATCCAT               SEQ ID NO: 974   CCTCTCCCCCACTCATCCATC               SEQ ID NO: 975   CTCTCCCCCTATCATCCATCG               SEQ ID NO: 976   TCTCCCCCTCACATCCATCGC               SEQ ID NO: 977   CTCCCCCTCTAATCCATCGCC               SEQ ID NO: 978   TCCCCCTCTCATCCATCGCCC               SEQ ID NO: 979   CCCCCTCTCAACCATCGCCCG               SEQ ID NO: 980   TACATTGCCCATGTAATTAA               SEQ ID NO: 981   ATATAGTTTCGTCATTCATC               SEQ ID NO: 982   TACATTGCCCATGTAATTAA               SEQ ID NO: 983   ATATAGTTTCGTCATTCATC               SEQ ID NO: 984   AGATAGTTTAGTCATTCATC               SEQ ID NO: 985   AGATAGTTTCATCATTCATC               SEQ ID NO: 986   AGATAGTTTCGACATTCATC               SEQ ID NO: 987   AGATAGTTTCGTAATTCATC               SEQ ID NO: 988   CCCCTCTCATACATCGCCCGC               SEQ ID NO: 989   CCCTCTCATCAATCGCCCGCC               SEQ ID NO: 990   CCTCTCATCCATCGCCCGCCG               SEQ ID NO: 991   CTCTCATCCAACGCCCGCCGC               SEQ ID NO: 992   TCTCATCCATAGCCCGCCGCC               SEQ ID NO: 993   CTCATCCATCACCCGCCGCCC               SEQ ID NO: 994   TCATCCATCGACCGCCGCCCC               SEQ ID NO: 995   CATCCATCGCACGCCGCCCCT               SEQ ID NO: 996   ATCCATCGCCAGCCGCCCCTC               SEQ ID NO: 997   TCCATCGCCCACCGCCCCTCA               SEQ ID NO: 998   CCATCGCCCGACGCCCCTCAT               SEQ ID NO: 999   CATCGCCCGCAGCCCCTCATC               SEQ ID NO: 1000   ATCGCCCGCCACCCCTCATCA               SEQ ID NO: 1001   TCGCCCGCCGACCCTCATCAT               SEQ ID NO: 1002   CGCCCGCCGCACCTCATCATA               SEQ ID NO: 1003   GCCCGCCGCCACTCATCATAC               SEQ ID NO: 1004   CCCGCCGCCCATCATCATACC               SEQ ID NO: 1005   CCGCCGCCCCACATCATACCT               SEQ ID NO: 1006   CGCCGCCCCTAATCATACCTC               SEQ ID NO: 1007   GCCGCCCCTCATCATACCTCA               SEQ ID NO: 1008   CCGCCCCTCAACATACCTCAG               SEQ ID NO: 1009   CGCCCCTCATTATACCTCAGC               SEQ ID NO: 1010   GCCCCTCATCTTACCTCAGCC               SEQ ID NO: 1011   CCCCTCATCATACCTCAGCCG               SEQ ID NO: 1012   CCCTCATCATTCCTCAGCCGC               SEQ ID NO: 1013   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1014   TACATTGCCCATGTAATTAA               SEQ ID NO: 1015   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1016   TACATTGCCCATGTAATTAA               SEQ ID NO: 1017   AGATAGTTTTGTCATTCATC               SEQ ID NO: 1018   AGATAGTTTCTTCATTCATC               SEQ ID NO: 1019   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1020   AGATAGTTTCGTTATTCATC               SEQ ID NO: 1021   CCTCATCATATCTCAGCCGCC               SEQ ID NO: 1022   CTCATCATACTTCAGCCGCCG               SEQ ID NO: 1023   TCATCATACCTCAGCCGCCGC               SEQ ID NO: 1024   CATCATACCTTAGCCGCCGCC               SEQ ID NO: 1025   ATCATACCTCTGCCGCCGCCC               SEQ ID NO: 1026   TCATACCTCATCCGCCGCCCC               SEQ ID NO: 1027   CATACCTCAGTCGCCGCCCCT               SEQ ID NO: 1028   ATACCTCAGCTGCCGCCCCTC               SEQ ID NO: 1029   TACCTCAGCCTCCGCCCCTCA               SEQ ID NO: 1030   ACCTCAGCCGTCGCCCCTCAT               SEQ ID NO: 1031   CCTCAGCCGCTGCCCCTCATC               SEQ ID NO: 1032   CTCAGCCGCCTCCCCTCATCA               SEQ ID NO: 1033   TCAGCCGCCGTCCCTCATCAT               SEQ ID NO: 1034   CAGCCGCCGCTCCTCATCATA               SEQ ID NO: 1035   AGCCGCCGCCTCTCATCATAC               SEQ ID NO: 1036   GCCGCCGCCCTTCATCATACC               SEQ ID NO: 1037   CCGCCGCCCCTCATCATACCT               SEQ ID NO: 1038   CGCCGCCCCTTATCATACCTC               SEQ ID NO: 1039   GCCGCCCCTCTTCATACCTCA               SEQ ID NO: 1040   CCGCCCCTCATCATACCTCAA               SEQ ID NO: 1041   CGCCCCTCATTATACCTCAAA               SEQ ID NO: 1042   GCCCCTCATCTTACCTCAAAA               SEQ ID NO: 1043   CCCCTCATCATACCTCAAAAG               SEQ ID NO: 1044   CCCTCATCATTCCTCAAAAGC               SEQ ID NO: 1045   CGCCCCTCATGATACCTCAGC               SEQ ID NO: 1046   GCCCCTCATCGTACCTCAGCC               SEQ ID NO: 1047   CCCCTCATCAGACCTCAGCCG               SEQ ID NO: 1048   CCCTCATCATGCCTCAGCCGC               SEQ ID NO: 1049   TACATTGCCCATGTAATTAA               SEQ ID NO: 1050   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1051   TACATTGCCCATGTAATTAA               SEQ ID NO: 1052   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1053   AGATAGTTTGGTCATTCATC               SEQ ID NO: 1054   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1055   AGATAGTTTCGGCATTCATC               SEQ ID NO: 1056   AGATAGTTTCGTGATTCATC               SEQ ID NO: 1057   CCTCATCATAGCTCAGCCGCC               SEQ ID NO: 1058   CTCATCATACGTCAGCCGCCG               SEQ ID NO: 1059   TCATCATACCGCAGCCGCCGC               SEQ ID NO: 1060   CATCATACCTGAGCCGCCGCC               SEQ ID NO: 1061   ATCATACCTCGGCCGCCGCCC               SEQ ID NO: 1062   TCATACCTCAGCCGCCGCCCC               SEQ ID NO: 1063   CATACCTCAGGCGCCGCCCCT               SEQ ID NO: 1064   ATACCTCAGCGGCCGCCCCTC               SEQ ID NO: 1065   TACCTCAGCCGCCGCCCCTCA               SEQ ID NO: 1066   ACCTCAGCCGGCGCCCCTCAT               SEQ ID NO: 1067   CCTCAGCCGCGGCCCCTCATC               SEQ ID NO: 1068   CTCAGCCGCCGCCCCTCATCA               SEQ ID NO: 1069   TCAGCCGCCGGCCCTCATCAT               SEQ ID NO: 1070   CAGCCGCCGCGCCTCATCATA               SEQ ID NO: 1071   AGCCGCCGCCGCTCATCATAC               SEQ ID NO: 1072   GCCGCCGCCCGTCATCATACC               SEQ ID NO: 1073   CCGCCGCCCCGCATCATACCT               SEQ ID NO: 1074   CGCCGCCCCTGATCATACCTC               SEQ ID NO: 1075   GCCGCCCCTCGTCATACCTCA               SEQ ID NO: 1076   CCGCCCCTCAGCATACCTCAA               SEQ ID NO: 1077   CGCCCCTCATGATACCTCAAA               SEQ ID NO: 1078   GCCCCTCATCGTACCTCAAAA               SEQ ID NO: 1079   CCCCTCATCAGACCTCAAAAG               SEQ ID NO: 1080   CCCTCATCATGCCTCAAAAGC               SEQ ID NO: 1081   CGCCCCTCATCATACCTCAGC               SEQ ID NO: 1082   GCCCCTCATCCTACCTCAGCC               SEQ ID NO: 1083   CCCCTCATCACACCTCAGCCG               SEQ ID NO: 1084   CCCTCATCATCCCTCAGCCGC               SEQ ID NO: 1085   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1086   TACATTGCCCATGTAATTAA               SEQ ID NO: 1087   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1088   TACATTGCCCATGTAATTAA               SEQ ID NO: 1089   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1090   AGATAGTTTCCTCATTCATC               SEQ ID NO: 1091   AGATAGTTTCGCCATTCATC               SEQ ID NO: 1092   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1093   CCTCATCATACCTCAGCCGCC               SEQ ID NO: 1094   CTCATCATACCTCAGCCGCCG               SEQ ID NO: 1095   TCATCATACCCCAGCCGCCGC               SEQ ID NO: 1096   CATCATACCTCAGCCGCCGCC               SEQ ID NO: 1097   ATCATACCTCCGCCGCCGCCC               SEQ ID NO: 1098   TCATACCTCACCCGCCGCCCC               SEQ ID NO: 1099   CATACCTCAGCCGCCGCCCCT               SEQ ID NO: 1100   ATACCTCAGCCGCCGCCCCTC               SEQ ID NO: 1101   TACCTCAGCCCCCGCCCCTCA               SEQ ID NO: 1102   ACCTCAGCCGCCGCCCCTCAT               SEQ ID NO: 1103   CCTCAGCCGCCGCCCCTCATC               SEQ ID NO: 1104   CTCAGCCGCCCCCCCTCATCA               SEQ ID NO: 1105   TCAGCCGCCGCCCCTCATCAT               SEQ ID NO: 1106   CAGCCGCCGCCCCTCATCATA               SEQ ID NO: 1107   AGCCGCCGCCCCTCATCATAC               SEQ ID NO: 1108   GCCGCCGCCCCTCATCATACC               SEQ ID NO: 1109   CCGCCGCCCCCCATCATACCT               SEQ ID NO: 1110   CGCCGCCCCTCATCATACCTC               SEQ ID NO: 1111   GCCGCCCCTCCTCATACCTCA               SEQ ID NO: 1112   CCGCCCCTCACCATACCTCAA               SEQ ID NO: 1113   CGCCCCTCATCATACCTCAAA               SEQ ID NO: 1114   GCCCCTCATCCTACCTCAAAA               SEQ ID NO: 1115   CCCCTCATCACACCTCAAAAG               SEQ ID NO: 1116   CCCTCATCATCCCTCAAAAGC               SEQ ID NO: 1117   CGCCCCTCATAATACCTCAGC               SEQ ID NO: 1118   GCCCCTCATCATACCTCAGCC               SEQ ID NO: 1119   CCCCTCATCAAACCTCAGCCG               SEQ ID NO: 1120   CCCTCATCATACCTCAGCCGC               SEQ ID NO: 1121   TACATTGCCCATGTAATTAA               SEQ ID NO: 1122   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1123   TACATTGCCCATGTAATTAA               SEQ ID NO: 1124   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1125   AGATAGTTTAGTCATTCATC               SEQ ID NO: 1126   AGATAGTTTCATCATTCATC               SEQ ID NO: 1127   AGATAGTTTCGACATTCATC               SEQ ID NO: 1128   AGATAGTTTCGTAATTCATC               SEQ ID NO: 1129   CCTCATCATAACTCAGCCGCC               SEQ ID NO: 1130   CTCATCATACATCAGCCGCCG               SEQ ID NO: 1131   TCATCATACCACAGCCGCCGC               SEQ ID NO: 1132   CATCATACCTAAGCCGCCGCC               SEQ ID NO: 1133   ATCATACCTCAGCCGCCGCCC               SEQ ID NO: 1134   TCATACCTCAACCGCCGCCCC               SEQ ID NO: 1135   CATACCTCAGACGCCGCCCCT               SEQ ID NO: 1136   ATACCTCAGCAGCCGCCCCTC               SEQ ID NO: 1137   TACCTCAGCCACCGCCCCTCA               SEQ ID NO: 1138   ACCTCAGCCGACGCCCCTCAT               SEQ ID NO: 1139   CCTCAGCCGCAGCCCCTCATC               SEQ ID NO: 1140   CTCAGCCGCCACCCCTCATCA               SEQ ID NO: 1141   TCAGCCGCCGACCCTCATCAT               SEQ ID NO: 1142   CAGCCGCCGCACCTCATCATA               SEQ ID NO: 1143   AGCCGCCGCCACTCATCATAC               SEQ ID NO: 1144   GCCGCCGCCCATCATCATACC               SEQ ID NO: 1145   CCGCCGCCCCACATCATACCT               SEQ ID NO: 1146   CGCCGCCCCTAATCATACCTC               SEQ ID NO: 1147   GCCGCCCCTCATCATACCTCA               SEQ ID NO: 1148   CCGCCCCTCAACATACCTCAA               SEQ ID NO: 1149   CGCCCCTCATAATACCTCAAA               SEQ ID NO: 1150   GCCCCTCATCATACCTCAAAA               SEQ ID NO: 1151   CCCCTCATCAAACCTCAAAAG               SEQ ID NO: 1152   CCCTCATCATACCTCAAAAGC               SEQ ID NO: 1153   CCTCATCATATCTCAAAAGCC               SEQ ID NO: 1154   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1155   TACATTGCCCATGTAATTAA               SEQ ID NO: 1156   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1157   TACATTGCCCATGTAATTAA               SEQ ID NO: 1158   AGATAGTTTTGTCATTCATC               SEQ ID NO: 1159   AGATAGTTTCTTCATTCATC               SEQ ID NO: 1160   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1161   AGATAGTTTCGTTATTCATC               SEQ ID NO: 1162   CTCATCATACTTCAAAAGCCA               SEQ ID NO: 1163   TCATCATACCTCAAAAGCCAA               SEQ ID NO: 1164   CATCATACCTTAAAAGCCAAC               SEQ ID NO: 1165   ATCATACCTCTAAAGCCAACT               SEQ ID NO: 1166   TCATACCTCATAAGCCAACTA               SEQ ID NO: 1167   CATACCTCAATAGCCAACTAA               SEQ ID NO: 1168   ATACCTCAAATGCCAACTAAC               SEQ ID NO: 1169   TACCTCAAAATCCAACTAACC               SEQ ID NO: 1170   ACCTCAAAAGTCAACTAACCA               SEQ ID NO: 1171   CCTCAAAAGCTAACTAACCAA               SEQ ID NO: 1172   CTCAAAAGCCTACTAACCAAC               SEQ ID NO: 1173   TCAAAAGCCATCTAACCAACC               SEQ ID NO: 1174   CAAAAGCCAATTAACCAACCA               SEQ ID NO: 1175   AAAAGCCAACTAACCAACCAA               SEQ ID NO: 1176   AAAGCCAACTTACCAACCAAT               SEQ ID NO: 1177   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1178   TACATTGCCCATGTAATTAA               SEQ ID NO: 1179   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1180   TACATTGCCCATGTAATTAA               SEQ ID NO: 1181   AGATAGTTTTGTCATTCATC               SEQ ID NO: 1182   AGATAGTTTCTTCATTCATC               SEQ ID NO: 1183   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1184   AGATAGTTTCGTTATTCATC               SEQ ID NO: 1185   CCTCATCATAGCTCAAAAGCC               SEQ ID NO: 1186   TACATTGCCCATGTAATTAA               SEQ ID NO: 1187   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1188   TACATTGCCCATGTAATTAA               SEQ ID NO: 1189   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1190   AGATAGTTTGGTCATTCATC               SEQ ID NO: 1191   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1192   AGATAGTTTCGGCATTCATC               SEQ ID NO: 1193   AGATAGTTTCGTGATTCATC               SEQ ID NO: 1194   CTCATCATACGTCAAAAGCCA               SEQ ID NO: 1195   TCATCATACCGCAAAAGCCAA               SEQ ID NO: 1196   CATCATACCTGAAAAGCCAAC               SEQ ID NO: 1197   ATCATACCTCGAAAGCCAACT               SEQ ID NO: 1198   TCATACCTCAGAAGCCAACTA               SEQ ID NO: 1199   CATACCTCAAGAGCCAACTAA               SEQ ID NO: 1200   ATACCTCAAAGGCCAACTAAC               SEQ ID NO: 1201   TACCTCAAAAGCCAACTAACC               SEQ ID NO: 1202   ACCTCAAAAGGCAACTAACCA               SEQ ID NO: 1203   CCTCAAAAGCGAACTAACCAA               SEQ ID NO: 1204   CTCAAAAGCCGACTAACCAAC               SEQ ID NO: 1205   TCAAAAGCCAGCTAACCAACC               SEQ ID NO: 1206   CAAAAGCCAAGTAACCAACCA               SEQ ID NO: 1207   AAAAGCCAACGAACCAACCAA               SEQ ID NO: 1208   AAAGCCAACTGACCAACCAAT               SEQ ID NO: 1209   TACATTGCCCATGTAATTAA               SEQ ID NO: 1210   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1211   TACATTGCCCATGTAATTAA               SEQ ID NO: 1212   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1213   AGATAGTTTGGTCATTCATC               SEQ ID NO: 1214   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1215   AGATAGTTTCGGCATTCATC               SEQ ID NO: 1216   AGATAGTTTCGTGATTCATC               SEQ ID NO: 1217   CCTCATCATACCTCAAAAGCC               SEQ ID NO: 1218   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1219   TACATTGCCCATGTAATTAA               SEQ ID NO: 1220   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1221   TACATTGCCCATGTAATTAA               SEQ ID NO: 1222   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1223   AGATAGTTTCCTCATTCATC               SEQ ID NO: 1224   AGATAGTTTCGCCATTCATC               SEQ ID NO: 1225   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1226   CTCATCATACCTCAAAAGCCA               SEQ ID NO: 1227   TCATCATACCCCAAAAGCCAA               SEQ ID NO: 1228   CATCATACCTCAAAAGCCAAC               SEQ ID NO: 1229   ATCATACCTCCAAAGCCAACT               SEQ ID NO: 1230   TCATACCTCACAAGCCAACTA               SEQ ID NO: 1231   CATACCTCAACAGCCAACTAA               SEQ ID NO: 1232   ATACCTCAAACGCCAACTAAC               SEQ ID NO: 1233   TACCTCAAAACCCAACTAACC               SEQ ID NO: 1234   ACCTCAAAAGCCAACTAACCA               SEQ ID NO: 1235   CCTCAAAAGCCAACTAACCAA               SEQ ID NO: 1236   CTCAAAAGCCCACTAACCAAC               SEQ ID NO: 1237   TCAAAAGCCACCTAACCAACC               SEQ ID NO: 1238   CAAAAGCCAACTAACCAACCA               SEQ ID NO: 1239   AAAAGCCAACCAACCAACCAA               SEQ ID NO: 1240   AAAGCCAACTCACCAACCAAT               SEQ ID NO: 1241   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1242   TACATTGCCCATGTAATTAA               SEQ ID NO: 1243   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1244   TACATTGCCCATGTAATTAA               SEQ ID NO: 1245   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1246   AGATAGTTTCCTCATTCATC               SEQ ID NO: 1247   AGATAGTTTCGCCATTCATC               SEQ ID NO: 1248   AGATAGTTTCGTCATTCATC               SEQ ID NO: 1249   CCTCATCATAACTCAAAAGCC               SEQ ID NO: 1250   TACATTGCCCATGTAATTAA               SEQ ID NO: 1251   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1252   TACATTGCCCATGTAATTAA               SEQ ID NO: 1253   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1254   AGATAGTTTAGTCATTCATC               SEQ ID NO: 1255   AGATAGTTTCATCATTCATC               SEQ ID NO: 1256   AGATAGTTTCGACATTCATC               SEQ ID NO: 1257   AGATAGTTTCGTAATTCATC               SEQ ID NO: 1258   CTCATCATACATCAAAAGCCA               SEQ ID NO: 1259   TCATCATACCACAAAAGCCAA               SEQ ID NO: 1260   CATCATACCTAAAAAGCCAAC               SEQ ID NO: 1261   ATCATACCTCAAAAGCCAACT               SEQ ID NO: 1262   TCATACCTCAAAAGCCAACTA               SEQ ID NO: 1263   CATACCTCAAAAGCCAACTAA               SEQ ID NO: 1264   ATACCTCAAAAGCCAACTAAC               SEQ ID NO: 1265   TACCTCAAAAACCAACTAACC               SEQ ID NO: 1266   ACCTCAAAAGACAACTAACCA               SEQ ID NO: 1267   CCTCAAAAGCAAACTAACCAA               SEQ ID NO: 1268   CTCAAAAGCCAACTAACCAAC               SEQ ID NO: 1269   TCAAAAGCCAACTAACCAACC               SEQ ID NO: 1270   CAAAAGCCAAATAACCAACCA               SEQ ID NO: 1271   AAAAGCCAACAAACCAACCAA               SEQ ID NO: 1272   AAAGCCAACTAACCAACCAAT               SEQ ID NO: 1273   TACATTGCCCATGTAATTAA               SEQ ID NO: 1274   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1275   TACATTGCCCATGTAATTAA               SEQ ID NO: 1276   ATATAGTTTCGTCATTCATC               SEQ ID NO: 1277   AGATAGTTTAGTCATTCATC               SEQ ID NO: 1278   AGATAGTTTCATCATTCATC               SEQ ID NO: 1279   AGATAGTTTCGACATTCATC               SEQ ID NO: 1280   AGATAGTTTCGTAATTCATC                  
 
         [0058]    Procedure for Probe Design  
         [0059]    The design of a probe begins with the input of a sequence file into a computer in the five prime to three prime direction. The sequence file is then converted to account for sodium bisulfite treatment. The complementary sequence of the converted sequence file is then is then generated in the three prime to five prime direction.  
         [0060]    A parent probe list is then created from the complementary sequence. This is accomplished by standard re-sequencing, where every base is queried. For this method the first probe starts at position X, and extend a number of bases, N. The next probe starts at position X+1, and extends N bases also. A second method to create the parent probe set is to identify all CpG dinucleotides and only create probes with a CpG dinucleotide in the middle.  
         [0061]    Once prepared, the parent probe list is filtered to remove probes that are deemed not to be suitable for re-sequencing analysis. Factors such as low sequence complexity are taken into account. Each parent probe is used as a template to create new probes to query for possible changes at a particular position in the reference sequence. Each parent probe generates at least three new probes, one for each single nucleotide polymorphism at the central base. The parent probe and daughter probes created from it represent the position query probe partners. Additional position query probe partners may be required if multiple CpG islands are on one probe. In this case every possible combination of methylation sites from the parent probe must be created. This creates a list of sub parent probes each of whose central position is then altered to represent all possible single nucleotide polymorphisms. The collection of these probes are that position&#39;s position query probe partners.  
         [0062]    Once the complete set of position query probe partners has been calculated, a file is generated containing all the partners for each position in the reference sequence, or those designated by the user for interrogation. A probe set generated in this manner for a portion of p16 is attached as Appendix 1.  
         [0063]    Sodium Bisulfite Treatment Protocol  
         [0064]    The concentration of DNA used in this protocol is 1 μg of DNA per 10 μl of sample. Samples are prepared in an autoclaved tube with 1 μg of DNA diluted to 50 μl using autoclaved water. 5.5 μl of 2M sodium hydroxide (3.6 g in 45 ml of water) is then added and the sample is maintained at 37° C. for ten minutes in a water bath. The sample tube is removed from the water bath and centrifuged. 30 μl of freshly prepared hydroquinone solution (55 mg in 50 ml of water) is added to the sample tube and the sample becomes yellow. 520 μl of freshly prepared sodium bisulfite solution (3.76 g in 10 ml of water) is then added and the resulting solution is mixed well. The sample tube is then sealed with parafilm and placed in a water bath at 60° C. for 16 hours. The tubes are removed from the water bath and the sample purified using the Wizard DNA resin (Promega) according to the manufacturer&#39;s protocol. The DNA is eluted with 50 μl of water to which is added 8.25 μl of 2M sodium hydroxide solution. The DNA is then precipitated using ethanol and a glycogen carrier. The precipitated DNA is then resuspended in 200 μl of water.  
         [0065]    Protocol for PCR Amplification of 145 bp Region of the Promoter for p16  
         [0066]    The primers listed below are examples of those used for the amplification.  
                               Primer Sequences:               5′ (Cy3/Cy5) GTTTTCCCAGTCACGACTTGGTTGGTTATTAGAGGGTGG 3′   (SEQ ID NO.: 1281)               5′ (Cy3/Cy5) AAACAGCTATGACCATGACCATAACCAACCAATCAACC 3′   (SEQ ID NO.: 1282)               The entire 145 base sequence:       5′CTGGCTG GTCACCAGAGGGTGGGGCGG ACCGAGTGCG CTCGGCGGCT   (SEQ ID NO.: 1283)               GCGGAGAGGG GTAGAGCAGG CAGCGGGCGGCGGGGAGCAG CATGGAGCCG               GCGGCGGGGA GCAGCATGGA GCCTTCGGCT GACTGGCTGG CCACGGC3′          
 
         [0067]    The following procedure is typically done 50 times, and the resulting material combined to form a single sample. Each amplification is accomplished by adding 3.2 μl of dNTP mixture (1.25 μM in each base), 2.5 μl of 10×PCR buffer, 1 μl of primer mixture (25 μM for each primer), 17 μl of water, 0.2 μl Taq polymerase (5 units/μl) and 1 μl of template DNA from the bisulfite treatment protocol described above.  
         [0068]    The thermocycler is then programmed to 95° C. for 12 minutes. This is followed by two cycles of treatment at 94° C. for 20 seconds, 66° C. for 40 seconds and 72° C. for 20 seconds with touchdown of −1° C. This is followed by 35 cycles of treatment at 94° C. for 20 seconds, 66° C. for 30 seconds and 72° C. for 20 seconds with touchdown of −1° C. The sample is then kept at 72° C. got 7 minutes and stored at 4° C.  
       EXAMPLE 2  
     Analysis of Methylation of a Region of the Promoter for the Tumor Suppressor Gene p16 with Oligonucleotide Arrays  
       [0069]    An example of a method for mapping individual sites of CpG methylation in genomic DNA is further presented herein. The method of the present invention allows parallel and simultaneous analysis of many individual potential sites of methylation in widely separated regions of the genome.  
         [0070]    Array Fabrication  
         [0071]    Corning 1″×3″ glass microscope slides were cleaned and coated with 3-glycidoxypropyltrimethoxysilane (Aldrich) and polyethlyeneglycol (M a  300, Aldrich) as described by Maskos and Southern. Slides were stored in a dessicator at room temperature until use. In preparation for microarray fabrication, the synthesis area of a slide was reacted with a 1:1 (vol:vol) mixture of 0.1 M protected linker phosphoramidite (MeNPOC-hexaethylene glycol β-cyanoethyl phosphoramidite) and tetrazole in acetonitrile (Annovis, Aston, Pa.). The mixture was allowed to react for two minutes with the glass surface and then washed with acetonitrile.  
         [0072]    An array of oligonucleotide probes was synthesized in situ on the resulting surface using light directed phosphoramidite synthesis. MenPOC-protected phosphoramidites were used in the synthesis. Light for each photochemical deprotection step was spatially addressed with a Texas Instruments Digital Light Processor (DLP™). The DLP was illuminated with the 365 nm peak from a 200 W Hg/Xe arc lamp. Illumination of the DLP and projection of the reflected image were accomplished with a custom optical system designed by Brilliant Technologies (Denton, Tex.). The image of the DLP was projected onto the reactive surface without magnification. The DLP was coordinated with a home-built fluidics system for automated DNA synthesis. Custom software generated the patterns of illumination required to fabricate the desired array of oligonucleotides. Final deprotection of the synthesized array was with a 1:1 (vol:vol) solution of ethylenediamine and ethanol for two hours at room temperature.  
         [0073]    Preparation of DNA and Amplification of Promoter Regions  
         [0074]    Cell lines H1299 and H69 were established as described by Phelps and co-workers (Phelps R, Johnson B, Ihde D, et al., NCI-Navy medical oncology branch cell line data base, Journal of Cellular Biochemistry Supplement. 24: 32-91, 1996) and have been deposited in the American Type Culture Collection. The cells were cultured in RPMI 1640 (Invitrogen) supplemented with 5% fetal bovine serum. Genomic DNA was purified from these cell lines as described by Fong et al. (Fong L, Zimmerman P, and Smith P, Correlation of loss of heterozygosity at 11 p with tumour progression and survival in non-small cell lung cancer, Genes, Chromosomes, Cancer. 10: 183-189, 1994). The extracted, purified DNA was treated with sodium bisulfite. Thep16 promoter region was amplified in a PCR reaction using 50 ng sodium bisulfite-treated genomic DNA as template and the following primers: 5′[Cy3 or biotin] TTAGAGGATTTGAGGGAT3′ (SEQ ID NO.: 1284) and 5′AAAACTCCATACTACTCC 3′ (SEQ ID NO.: 1285). Primers were purchased from Operon Technologies (Alameda, Calif.).  
         [0075]    A touchdown method was used for the first 14 cycles of amplification, starting at an annealing temperature of 68° C. and decreasing the annealing temperature 1° C. per cycle. Amplification was continued for an additional 30 cycles with an annealing temperature of 55° C. Denaturation and extension were carried out at 94° C. and 72° C., respectively. The product of this amplification was used as the template for a second set of PCR reactions. The products were de-salted (NAP column, Amersham Pharmacia Biotech) and precipitated with ethanol and sodium acetate prior to dissolving in hybridization buffer.  
         [0076]    Array Hybridization  
         [0077]    The hybridization mixture contained, 0.1-1 μM labeled analyte sample, 0.1-1 μM labeled reference sample, 1 μM Control Oligo 1 (SEQ ID NO.: 1286, 5′[Cy3] CTTGGCTGTCCCAGAATGCAAGAAGCCCAGACGGAAACCGTAGCTGCCCTGGTA GGTTTT), and 1 μM Control Oligo 2 (SEQ ID NO.: 1287, 5′[Cy3] TATATCAAAGCAGTAAGTAG) in 3M tetramethyl ammonium chloride, 0.05% Trition X-100,1 mM EDTA, 10 mM Tris HCl pH7.5. The sample was applied to the array surface under a 22×22 mm cover slip. Hybridization was carried out in a closed chamber containing a pool of hybridization buffer. The array with sample was heated to 95° C. for 20 minutes followed by warming at 60° C. for one hour. After hybridization, the array was washed three times with 6×SSPE (Sigma), 0.09% Tween, followed by three washes with 0.8×SSPE, 0.01% Tween at room temperature. After this wash, the array was dried centrifugally, stained with 2 μg/ml of CyS-Streptavidin (vendor) for 5 minutes at room temperature, washed with 6×SSPE, 0.09% Tween. Finally, the array was scanned using an Axon Genepix 3000 scanner to detect Cy3 and Cy5 fluorescence intensity. The signal intensity for each feature was determined using custom analysis software.  
         [0078]    TA Cloning and Sequencing  
         [0079]    The 190 base pair amplicon of sodium bisulfite treated DNA was cloned into plasmid pCR®2.1 using a TA cloning kit (Invitrogen, Carlsbad, Calif.) and manufacturer recommended protocols. Plasmid was isolated from 18 individual colonies, and the insert was sequenced. Sequencing was done on an ABI3100 sequencer with T7 and M13 primers using dye terminated DNA sequencing protocols.  
         [0080]    Construction of 190 bp Duplex for Heterogeneous Methylation Study  
         [0081]    A 190 base pair duplex with simulated methylation at position 25 was created. Oligonucleotides were obtained from Operon Technologies. The following oligonucleotides were obtained from Operon Technologies: Oligo A (SEQ ID NO.: 1288, 5′CCACCCTCTAATAACCAACCAACCCCTCCTCTTTCTTCCTCCAATACTAACAAA AAAACCCCCTCCAACCCTATCCCTCAAATCCTCTAA), Oligo B (SEQ ID NO.: 1289, 5′GTGTGTTTGGTGGTTG C GGAGAGGGGGAGAGTAGGTAGTGGGTGGTGGGGAGT AGTATGGAGTTGGTGGTGGGGAGTAGTATGGAGTTTT), Oligo C (SEQ ID NO.: 1290, 5′TTAGAGGATTTGAGGGATAGGGTTGGAGGGGGTTTTTTTGTTAGTATTGGAGG AAGAAAGAGGAGGGGTTGGTTGGTTATTAGAGGGTGGGGTGGATTGT), and Oligo D (SEQ ID NO.: 1291, 5′AAAACTCCATACTACTCCCCACCACCAACTCCATA CTACTCCCCACCACCCACTACCTACTCTCCCCCTCTCC G CAACCACCAAACACAC ACAATCCACC). Oligos A and B (70 pmoles each) were phosphorylated with polynucleotide kinase (New England BioLabs). The phosphorylated DNA was phenol extracted, chloroform extracted, then ethanol precipitated. Phosphorylated Oligo A was annealed with Oligo C, and phosphorylated Oligo B was annealed with Oligo D. The resulting duplexes were mixed in equimolar amounts and ligated with T4 ligase at 14° C. overnight. The resulting 190 base pair duplex was amplified as described above for the p16 promoter region.  
         [0082]    Assay for Methylation by Hybridization to an Array of Oligonucleotide Probes  
         [0083]    An example of one ore more essential features of the present invention is shown schematically in FIG. 6. For FIG. 6, oligonucleotide probes are covalently bound to a substrate. The central base of each probe for a given position is varied to test for the identity of the base by hybridization. The probe with which the most label is associated identifies the base at the central position. A cytosine at the probed position indicates methylation that prevented conversion by sodium bisulfite. A sample of genomic DNA is treated with sodium bisulfite under conditions that convert unmethylated cytosines to deoxyuridines. Methylated cytosines remain unconverted (FIG. 6A). At least one region of interest is amplified by PCR, which recapitulates the deoxyuracils in the template as thymidines. The product is labeled during amplification with an easily detectable tag such as a fluorophore. The presence of a cytosine or a thymidine at each position corresponding to a site of potential methylation is assayed by hybridization to a set of complementary oligonucleotide probes covalently bound to a substrate (FIG. 6B). Each probe for a given position is identical, except for a center base substitution used to determine the analyte sequence by hybridization. Many different CpG sites may be simultaneously queried with an array of many oligonucleotide probes.  
         [0084]    A region of the promoter for the tumor suppressor gene p16 is tested using the method of the present invention. Hypermethylation of this promoter is known to repress transcription of p16 and is associated with a number of cancers. Samples of genomic DNA from lung tumor cell lines are treated with sodium bisulfite. In addition, a190 bp region of the p16 promoter is amplified and labeled. The sequence of the 190 base region of interest (prior to treatment with sodium bisulfite) is shown in FIG. 7 (GenBank accession number AL449423). After treatment with bisulfite, the strand shown was amplified and labeled. The region contains 36 cytosines. The numbers correspond to those are depicted in TABLE 2; 16 cytosines are within CpG dinucleotides (shaded) and 20 cytosines are not within CpG dinucleotides. The amplified DNA was analyzed by hybridization to an array of oligonucleotide probes, each 21 bases in length, synthesized directly on a glass surface by light-directed methods. Spatially patterned illumination for the photodeprotection step of the synthesis was accomplished using a digital micromirror device.  
         [0085]    The result of hybridization and scanning of four probes designed to query a single cytosine (cytosine number 1) is shown in FIG. 8. The array was hybridized, washed, and scanned for fluorescence. Each 21 -nucleotide probe is complementary to the sequence surrounding cytosine number 1, with a different base for each probe in apposition to cytosine number 1. For example, the probe for A has a thymidine in that central position. The DNA analyzed with the Cy5 label was from a lung tumor cell line (H1299) in which all of the CpG dinucleotides in the 190-base analyzed region were previously found to be methylated (by using dye terminated sequencing of bisulfite treated DNA). The feature with the highest signal of the four features shown is the one probing for a cytosine (the variable base in the probe is a guanine). The ratio of the signal for this feature to the next highest signal (in the feature probing for a guanine) is 2.8, identifying the base in the analyte as a cytosine. A cytosine at this position was anticipated as the outcome of bisulfite treatment of the methylated base.  
         [0086]    One comparison relevant to detection of methylation is between the signal in the feature that probes for a cytosine at each position and the signal in the feature that probes for a thymidine at the same position in the bisulfite treated DNA. The ratio of these signals (C:T) is listed for each of the cytosines in the analyzed sequence in TABLE 2. Cytosines outside of CpG dinucleotides that are not methylated serve as an internal indicator for the effectiveness of the bisulfite treatment in converting unmethylated cytosines to deoxyuracils and for the discrimination between cytosines and thymidines by the probes on the array. The ratio of signals in those features ranges from 0.24 to 1.09. Independent sequence analysis of the bisulfite-treated DNA confirmed complete conversion of all unmethylated cytosines to deoxyuracils. At the position queried by the probes shown in FIG. 8, the ratio of signals (C:T) is 3.57. The values range from 1.91 to 13.8 for cytosines in CpG dinucleotides (TABLE 2), in all cases considerably higher than the highest ratio of signals for the unmethylated cytosines.  
                                                                                                                                                                       TABLE 2                       Summary of Signal Intensity Ratios for Each Analyzed Cytosine                                    H1299 &amp; H69 d     25th C Duplex e              Cytosine   C:T Ratio   C:T Ratio   Analyte(C:T)/       C:T Ratio   C:T Ratio   Analyte(C:T)/           Number g     Analyte a     Reference a     Ref(C:T) b     Score c     Analyte a     Reference a     Ref(C:T) b     Z Score c                      1   3.57   0.52   6.80   10.7   0.86   0.88   0.99   −0.90       2   0.46   0.54   0.85   −1.50   0.74   0.69   1.08   −0.29       3   0.44   0.36   1.23   −0.72   0.75   0.75   1.00   −0.82       4   0.39   0.29   1.34   −0.50   0.87   0.86   1.01   −0.76       5   13.8   0.39   35.7   69.7   0.90   0.89   1.01   −0.75       6   0.24   0.22   1.13   −0.94   1.07   0.96   1.12   −0.08       7   0.34   0.36   0.94   −1.33   1.01   0.99   1.01   −0.72       8   0.36   0.41   0.88   −1.45   0.70   0.58   1.22   0.58       9   0.33   0.27   1.23   −0.73   0.68   0.65   1.05   −0.50       10   9.28   0.41   22.5   42.8   0.82   0.68   1.20   0.46       11   0.93   0.53   1.76   0.36   0.85   0.88   0.97   −1.00       12   1.09   0.48   2.29   1.44   1.01   0.72   1.41   1.79       13   0.65   0.52   1.23   −0.69   0.85   0.76   1.11   −0.10       14   0.65   0.51   1.23   −0.60   0.83   0.80   1.05   −0.52       15   1.08   0.60   1.81   0.44   0.92   0.93   0.99   −0.87       16   3.55   0.54   6.64   10.3   0.94   0.72   1.30   1.12       17   0.27   0.11   2.44   1.75   0.62   0.56   1.11   −0.11       18   1.99   0.46   4.34   5.62   0.9   1.06   0.85   −1.76       19   2.36   0.60   3.91   4.75   1.10   0.76   1.45   2.08       20   1.91   0.53   3.63   4.18   1.01   0.82   1.23   0.68       21   0.40   0.18   2.27   1.39   0.51   0.45   1.14   0.08       22   3.11   0.69   4.54   6.05   0.82   0.71   1.16   0.24       23   3.38   0.59   5.73   8.46   1.07   0.68   1.56   2.77       24   0.45   0.27   1.68   0.20   0.60   0.49   1.22   0.62       25   3.55   0.52   6.81   10.7   1.48   0.62   2.38   7.97       26   0.62   0.29   2.11   1.07   0.81   0.75   1.08   −0.29       27   0.46   0.29   1.58   −0.01   0.7   0.74   0.94   −1.17       28   2.88   0.52   5.52   8.02   1.00   0.89   1.12   −0.04       29   2.11   0.43   4.85   6.66   0.93   0.58   1.59   2.95       30   3.40   0.42   8.09   13.3   1.01   0.62   1.67   3.47       31   0.70   0.38   1.87   0.57   0.77   0.58   1.32   1.23       32   0.60   0.34   1.75   0.33   0.79   0.50   1.57   2.82       33   0.37   0.18   2.04   0.93   0.57   0.50   1.14   0.09       34   2.14   0.52   4.10   5.13   0.82   0.63   1.30   1.09       35   2.11   0.44   4.77   6.51   1.21   0.72   1.69   3.55       36   4.48   0.49   9.15   15.5   1.18   0.80   1.47   2.20                        20:80 Mixture f                  Cytosine   C:T Ratio   C:T Ratio   Analyte(C:T)/               Number g     Analyte a     Reference a     Ref(C:T) b     Z Score c                              1   0.99   0.52   1.92   4.61           2   0.70   0.70   1.00   1.01           3   0.39   0.32   1.20   1.80           4   0.44   0.36   1.22   1.88           5   1.16   0.49   2.35   6.29           6   0.32   0.64   0.5   −0.97           7   0.50   0.76   0.65   −0.37           8   0.36   0.62   0.58   −0.64           9   0.34   0.64   0.53   −0.85           10   1.43   0.67   2.15   5.51           11   0.62   0.90   0.69   −0.20           12   0.70   0.55   1.28   2.08           13   0.61   0.93   0.66   −0.35           14   0.51   0.68   0.74   −0.02           15   0.61   0.98   0.62   −0.48           16   1.90   0.86   2.21   5.71           17   0.20   0.51   0.39   −1.41           18   0.50   0.42   1.19   1.73           19   1.04   0.57   1.83   4.25           20   1.99   1.04   1.92   4.58           21   0.35   0.62   0.57   0.69           22   2.17   1.39   1.56   3.19           23   2.20   1.41   1.59   3.32           24   0.34   0.49   0.70   0.17           25   1.12   0.74   1.51   2.99           26   0.69   0.78   0.89   0.59           27   0.49   0.87   0.56   −0.73           28   1.24   0.63   1.98   4.82           29   0.93   0.96   0.96   0.85           30   0.91   1.11   0.82   0.29           31   0.59   0.73   0.81   0.25           32   0.53   0.67   0.80   0.21           33   0.30   0.59   0.51   −0.93           34   1.16   0.63   1.85   4.33           35   1.31   1.33   0.98   0.93           36   2.28   1.66   1.38   2.48                                                                                                          
 
         [0087]    To provide an objective standard for discrimination between methylated and unmethylated cytosines and to facilitate visualization of changes in methylation state, a reference sequence containing a different label was co-hybridized with the array. DNA from a different lung tumor cell line (H69) in which the p16 promoter has been found to be unmethylated at each CpG in the 190 base region of interest was used a model reference sequence. Results were confirmed using dye terminated sequencing of bisulfite-treated DNA. The same 190 base region (FIG. 7) of H69 was amplified with a primer labeled with Cy3.  
         [0088]    The result for cytosine number 1 is shown in FIGS. 8B and 8C. The probe for thymidine has the highest signal intensity, and the C:T ratio for the reference strand is 0.52 at this position. A useful method for judging changes in methylation state is to compare the C:T ratio for a set of probes with the analyte fluorophore to the C:T ratio for the same probes with the reference fluorophore. In FIG. 8 the ratio of sample fluorophore (Cy5) C:T ratio to reference fluorophore (Cy3) C:T ratio is 6.8. Using a ratio of ratios in this manner may, for example, reduce the effects of imperfect hybridization specificity on the results.  
         [0089]    The ratio of ratios was computed for each cytosine in the original sequence and is listed in TABLE 2. Cytosines not part of a CpG were used as an internal standard for unmethylated positions. The ratios of signal ratios for these cytosines had a mean of 1.59 and a standard deviation of 0.49 (n=20) and were distributed normally. In the H1299 sample, the values for all 16 cytosines in CpGs were at least four standard deviations from the mean of values for cytosines not in CpGs (FIG. 9A; Z scores listed in TABLE 2). A study in which the dye labels were reversed between the analyte and reference samples yielded equivalent results.  
         [0090]    Specificity for Detection of Heterogeneous Methylation  
         [0091]    The example of the present invention shows that the region of the p16 promoter is uniformly methylated at all CpG sites in the H1299 cell line. For non-uniformity of methylation that may have important biological consequences (e.g., because methylation of all CpG sites within a promoter region does not have equal effect on transcription), the ability for the assay to independently discriminate methylation states at different CpG sites is essential.  
         [0092]    The present invention may detect methylation at an individual site and define the threshold for assignment of methylation state. This may be shown, for example, by creating an 190 base pair test duplex (using chemical synthesis and ligation). One strand of the duplex is identical in sequence to bisulfite-treated H69 genomic DNA, except the position of the 25th cytosine simulates methylation by being a cytosine rather than a thymidine. The test duplex was labeled by amplification with a labeled primer, and bisulfite-treated DNA from H69 lung tumor cells was amplified and labeled for use as a reference sequence. Co-hybridization of the analyte and reference samples to the array resulted in the ratios of analyte(C:T) to reference(C:T) listed in TABLE 2 for all 36 cytosines.  
         [0093]    The site of simulated methylation had an analyte(C:T):reference(C:T) ratio of 2.38, nearly eight standard deviations (Z score=7.97) from the mean of that ratio for the cytosines not in CpG dinucleotides (1.13±0.16,n=20). This ratio for the other cytosines in CpGs ranged from 0.91 to 1.64. These differed from the mean for the internal standard cytosines by −1.8 to 3.6 standard deviations (FIG. 9B and TABLE 2). Thus, the authentic cytosine could be clearly distinguished from the other potential positions of methylation by its considerably larger variation from the internal standards. The range of ratios for the positions simulating unmethylated CpGs suggests a threshold Z score of greater than 3.6 (i.e., greater than 3.6 standard deviations from the mean of the internal standards) to indicate a genuine difference from an unmethylated cytosine. In FIG. 9, the threshold for calling methylation is set to 3.6, indicated by the horizontal line at that value. In each case the reference sample was derived from unmethylated DNA.  
         [0094]    Detection of Methylated DNA in the Presence of Unmethylated DNA  
         [0095]    The present invention is able to detect methylated cytosines within analytes that contain a significant amount of DNA that is not methylated, a feature that may be particularly useful with biological samples of genomic DNA that include individual CpG sites that are partially but not exhaustively methylated.  
         [0096]    The 190 base region shown in FIG. 7 was amplified separately from bisulfite-treated samples of genomic DNA from H1299 and H69. The amount of amplified DNA from each sample was estimated by visualization on an agarose gel, and the amplified samples were mixed in a ratio of approximately 20:80 (H1299:H69). This mixture approximates a sample in which 20% of each CpG is methylated. The mixture was labeled by an additional amplification with a labeled primer. A reference sample (derived purely from H69) was also amplified and labeled, and the analyte mixture and reference were co-hybridized to the methylation probe array.  
         [0097]    The results of this hybridization are summarized in TABLE 2. Of the 16 cytosines in CpG dinucleotides, 8 had Z scores greater than 3.6, identifying them as partially methylated (FIG. 9C). The remaining 8 could not be distinguished from bases converted entirely to deoxyuracils by treatment with bisulfite.  
         [0098]    The comparison to a sample of reference methylation state is especially useful, because information about differences in methylation state is important. Many comparisons may be used, such as, for example, comparing the difference between the analyte sample and a sample known to be unmethylated, comparing DNA from diseased tissue to a matched sample from healthy tissue or DNA from tissue at different points along a disease progression. In FIG. 8C, co-hybridization with a reference sample containing a different label facilitates visualization of changes in methylation state; the presence of two colors in one set of four probes may then be observed.  
         [0099]    Other aspects of variability of the present invention may be assessed using the known unmethylated positions as internal standards (generally performed after the context-dependence of variability is accounted for). For example, a calculated Z score offers a measure of the statistical significance of the difference between the analyte to reference ratio of a given interrogated cytosine and those known to be unmethylated. The use of an empirically determined threshold Z score to judge methylation state is analogous to the use of an empirically determined threshold signal ratio to identify nucleotides in standard array-based sequence analysis. As used herein, the calculated Z score correlates with methylation state, and a single cytosine corresponding to a uniquely methylated position is distinguished from the unmethylated cytosines.  
         [0100]    The present invention may detect methylation at an individual cytosine by hybridization to probes synthesized in situ using internal controls such as cytosines outside of CpG dinucleotides and a co-hybridized reference sample. The assay is designed to interrogate independent sites for methylation. With use of the present invention, additional probes may be included to interrogate other possible strands of DNA that reflect methylation status of a region. For example, after bisulfite treatment, the two strands of genomic DNA are no longer mutually complementary. Amplification of each produces two complementary strands of different sequence. Therefore, information about the methylation state of the initial sequence is contained in four different sequences of DNA, each of which can be analyzed independently on the same array.  
         [0101]    With the present invention, as few as two array features can be used to effectively probe each cytosine in a region of interest. For example, using light directed methods of high feature density array synthesis, hundreds of thousands of features can be created on a single array to probe, in parallel, hundreds of thousands of potential methylation sites in widely dispersed regions of the genome. This method of array synthesis that allows for high feature densities and facile changes in probe content is particularly valuable for the de novo discovery of sites of aberrant methylation states.  
         [0102]    Although the invention has been described in connection with specific embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Modifications and variations of the described compositions and methods of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Indeed, various modifications of the described compositions and modes of carrying out the invention that are obvious to those skilled in molecular biology or related arts are intended to be within the scope of the following claims.  
     
       
       
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aaccaaccaa taatctccca c                                               21 

 
           
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accaaccaat tatctcccac c                                               21 

 
           
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ccaaccaata ttctcccacc c                                               21 

 
           
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caaccaataa tctcccaccc c                                               21 

 
           
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aaccaataat ttcccacccc a                                               21 

 
           
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accaataatc tcccacccca c                                               21 

 
           
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ccaataatct tccaccccac c                                               21 

 
           
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caataatctc tcaccccacc t                                               21 

 
           
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aataatctcc taccccacct a                                               21 

 
           
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ataatctccc tccccaccta a                                               21 

 
           
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taatctccca tcccacctaa c                                               21 

 
           
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aatctcccac tccacctaac t                                               21 

 
           
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atctcccacc tcacctaact c                                               21 

 
           
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tctcccaccc tacctaactc a                                               21 

 
           
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ctcccacccc tcctaactca c                                               21 

 
           
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tcccacccca tctaactcac a                                               21 

 
           
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cccaccccac ttaactcaca c                                               21 

 
           
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ccaccccacc taactcacac a                                               21 

 
           
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caccccacct tactcacaca a                                               21 

 
           
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accccaccta tctcacacaa a                                               21 

 
           
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ccccacctaa ttcacacaaa c                                               21 

 
           
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cccacctaac tcacacaaac c                                               21 

 
           
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ccacctaact tacacaaacc a                                               21 

 
           
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cacctaactc tcacaaacca c                                               21 

 
           
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acctaactca tacaaaccac c                                               21 

 
           
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atatagtttc gtcattcatc                                                 20 

 
           
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tacattgccc atgtaattaa                                                 20 

 
           
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atatagtttc gtcattcatc                                                 20 

 
           
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tacattgccc atgtaattaa                                                 20 

 
           
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agatagtttt gtcattcatc                                                 20 

 
           
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agatagtttc ttcattcatc                                                 20 

 
           
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agatagtttc gtcattcatc                                                 20 

 
           
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agatagtttc gttattcatc                                                 20 

 
           
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cctaactcac tcaaaccacc a                                               21 

 
           
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ctaactcaca taaaccacca a                                               21 

 
           
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taactcacac taaccaccaa c                                               21 

 
           
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             Homo sapiens  
           
            37 

aaccaaccaa gaatctccca c                                               21 

 
           
             38  
             21  
             DNA  
             Homo sapiens  
           
            38 

accaaccaat gatctcccac c                                               21 

 
           
             39  
             21  
             DNA  
             Homo sapiens  
           
            39 

ccaaccaata gtctcccacc c                                               21 

 
           
             40  
             21  
             DNA  
             Homo sapiens  
           
            40 

caaccaataa gctcccaccc c                                               21 

 
           
             41  
             21  
             DNA  
             Homo sapiens  
           
            41 

aaccaataat gtcccacccc a                                               21 

 
           
             42  
             21  
             DNA  
             Homo sapiens  
           
            42 

accaataatc gcccacccca c                                               21 

 
           
             43  
             21  
             DNA  
             Homo sapiens  
           
            43 

ccaataatct gccaccccac c                                               21 

 
           
             44  
             21  
             DNA  
             Homo sapiens  
           
            44 

caataatctc gcaccccacc t                                               21 

 
           
             45  
             21  
             DNA  
             Homo sapiens  
           
            45 

aataatctcc gaccccacct a                                               21 

 
           
             46  
             21  
             DNA  
             Homo sapiens  
           
            46 

ataatctccc gccccaccta a                                               21 

 
           
             47  
             21  
             DNA  
             Homo sapiens  
           
            47 

taatctccca gcccacctaa c                                               21 

 
           
             48  
             21  
             DNA  
             Homo sapiens  
           
            48 

aatctcccac gccacctaac t                                               21 

 
           
             49  
             21  
             DNA  
             Homo sapiens  
           
            49 

atctcccacc gcacctaact c                                               21 

 
           
             50  
             21  
             DNA  
             Homo sapiens  
           
            50 

tctcccaccc gacctaactc a                                               21 

 
           
             51  
             21  
             DNA  
             Homo sapiens  
           
            51 

ctcccacccc gcctaactca c                                               21 

 
           
             52  
             21  
             DNA  
             Homo sapiens  
           
            52 

tcccacccca gctaactcac a                                               21 

 
           
             53  
             21  
             DNA  
             Homo sapiens  
           
            53 

cccaccccac gtaactcaca c                                               21 

 
           
             54  
             21  
             DNA  
             Homo sapiens  
           
            54 

ccaccccacc gaactcacac a                                               21 

 
           
             55  
             21  
             DNA  
             Homo sapiens  
           
            55 

caccccacct gactcacaca a                                               21 

 
           
             56  
             21  
             DNA  
             Homo sapiens  
           
            56 

accccaccta gctcacacaa a                                               21 

 
           
             57  
             21  
             DNA  
             Homo sapiens  
           
            57 

ccccacctaa gtcacacaaa c                                               21 

 
           
             58  
             21  
             DNA  
             Homo sapiens  
           
            58 

cccacctaac gcacacaaac c                                               21 

 
           
             59  
             21  
             DNA  
             Homo sapiens  
           
            59 

ccacctaact gacacaaacc a                                               21 

 
           
             60  
             21  
             DNA  
             Homo sapiens  
           
            60 

cacctaactc gcacaaacca c                                               21 

 
           
             61  
             21  
             DNA  
             Homo sapiens  
           
            61 

acctaactca gacaaaccac c                                               21 

 
           
             62  
             20  
             DNA  
             Homo sapiens  
           
            62 

tacattgccc atgtaattaa                                                 20 

 
           
             63  
             20  
             DNA  
             Homo sapiens  
           
            63 

atatagtttc gtcattcatc                                                 20 

 
           
             64  
             20  
             DNA  
             Homo sapiens  
           
            64 

tacattgccc atgtaattaa                                                 20 

 
           
             65  
             20  
             DNA  
             Homo sapiens  
           
            65 

atatagtttc gtcattcatc                                                 20 

 
           
             66  
             20  
             DNA  
             Homo sapiens  
           
            66 

agatagtttg gtcattcatc                                                 20 

 
           
             67  
             20  
             DNA  
             Homo sapiens  
           
            67 

agatagtttc gtcattcatc                                                 20 

 
           
             68  
             20  
             DNA  
             Homo sapiens  
           
            68 

agatagtttc ggcattcatc                                                 20 

 
           
             69  
             20  
             DNA  
             Homo sapiens  
           
            69 

agatagtttc gtgattcatc                                                 20 

 
           
             70  
             21  
             DNA  
             Homo sapiens  
           
            70 

cctaactcac gcaaaccacc a                                               21 

 
           
             71  
             21  
             DNA  
             Homo sapiens  
           
            71 

ctaactcaca gaaaccacca a                                               21 

 
           
             72  
             21  
             DNA  
             Homo sapiens  
           
            72 

taactcacac gaaccaccaa c                                               21 

 
           
             73  
             21  
             DNA  
             Homo sapiens  
           
            73 

aaccaaccaa caatctccca c                                               21 

 
           
             74  
             21  
             DNA  
             Homo sapiens  
           
            74 

accaaccaat catctcccac c                                               21 

 
           
             75  
             21  
             DNA  
             Homo sapiens  
           
            75 

ccaaccaata ctctcccacc c                                               21 

 
           
             76  
             21  
             DNA  
             Homo sapiens  
           
            76 

caaccaataa cctcccaccc c                                               21 

 
           
             77  
             21  
             DNA  
             Homo sapiens  
           
            77 

aaccaataat ctcccacccc a                                               21 

 
           
             78  
             21  
             DNA  
             Homo sapiens  
           
            78 

accaataatc ccccacccca c                                               21 

 
           
             79  
             21  
             DNA  
             Homo sapiens  
           
            79 

ccaataatct cccaccccac c                                               21 

 
           
             80  
             21  
             DNA  
             Homo sapiens  
           
            80 

caataatctc ccaccccacc t                                               21 

 
           
             81  
             21  
             DNA  
             Homo sapiens  
           
            81 

aataatctcc caccccacct a                                               21 

 
           
             82  
             21  
             DNA  
             Homo sapiens  
           
            82 

ataatctccc cccccaccta a                                               21 

 
           
             83  
             21  
             DNA  
             Homo sapiens  
           
            83 

taatctccca ccccacctaa c                                               21 

 
           
             84  
             21  
             DNA  
             Homo sapiens  
           
            84 

aatctcccac cccacctaac t                                               21 

 
           
             85  
             21  
             DNA  
             Homo sapiens  
           
            85 

atctcccacc ccacctaact c                                               21 

 
           
             86  
             21  
             DNA  
             Homo sapiens  
           
            86 

tctcccaccc cacctaactc a                                               21 

 
           
             87  
             21  
             DNA  
             Homo sapiens  
           
            87 

ctcccacccc ccctaactca c                                               21 

 
           
             88  
             21  
             DNA  
             Homo sapiens  
           
            88 

tcccacccca cctaactcac a                                               21 

 
           
             89  
             21  
             DNA  
             Homo sapiens  
           
            89 

cccaccccac ctaactcaca c                                               21 

 
           
             90  
             21  
             DNA  
             Homo sapiens  
           
            90 

ccaccccacc caactcacac a                                               21 

 
           
             91  
             21  
             DNA  
             Homo sapiens  
           
            91 

caccccacct cactcacaca a                                               21 

 
           
             92  
             21  
             DNA  
             Homo sapiens  
           
            92 

accccaccta cctcacacaa a                                               21 

 
           
             93  
             21  
             DNA  
             Homo sapiens  
           
            93 

ccccacctaa ctcacacaaa c                                               21 

 
           
             94  
             21  
             DNA  
             Homo sapiens  
           
            94 

cccacctaac ccacacaaac c                                               21 

 
           
             95  
             21  
             DNA  
             Homo sapiens  
           
            95 

ccacctaact cacacaaacc a                                               21 

 
           
             96  
             21  
             DNA  
             Homo sapiens  
           
            96 

cacctaactc ccacaaacca c                                               21 

 
           
             97  
             21  
             DNA  
             Homo sapiens  
           
            97 

acctaactca cacaaaccac c                                               21 

 
           
             98  
             20  
             DNA  
             Homo sapiens  
           
            98 

atatagtttc gtcattcatc                                                 20 

 
           
             99  
             20  
             DNA  
             Homo sapiens  
           
            99 

tacattgccc atgtaattaa                                                 20 

 
           
             100  
             20  
             DNA  
             Homo sapiens  
           
            100 

atatagtttc gtcattcatc                                                 20 

 
           
             101  
             20  
             DNA  
             Homo sapiens  
           
            101 

tacattgccc atgtaattaa                                                 20 

 
           
             102  
             20  
             DNA  
             Homo sapiens  
           
            102 

agatagtttc gtcattcatc                                                 20 

 
           
             103  
             20  
             DNA  
             Homo sapiens  
           
            103 

agatagtttc ctcattcatc                                                 20 

 
           
             104  
             20  
             DNA  
             Homo sapiens  
           
            104 

agatagtttc gccattcatc                                                 20 

 
           
             105  
             20  
             DNA  
             Homo sapiens  
           
            105 

agatagtttc gtcattcatc                                                 20 

 
           
             106  
             21  
             DNA  
             Homo sapiens  
           
            106 

cctaactcac ccaaaccacc a                                               21 

 
           
             107  
             21  
             DNA  
             Homo sapiens  
           
            107 

ctaactcaca caaaccacca a                                               21 

 
           
             108  
             21  
             DNA  
             Homo sapiens  
           
            108 

taactcacac caaccaccaa c                                               21 

 
           
             109  
             21  
             DNA  
             Homo sapiens  
           
            109 

aaccaaccaa aaatctccca c                                               21 

 
           
             110  
             21  
             DNA  
             Homo sapiens  
           
            110 

accaaccaat aatctcccac c                                               21 

 
           
             111  
             21  
             DNA  
             Homo sapiens  
           
            111 

ccaaccaata atctcccacc c                                               21 

 
           
             112  
             21  
             DNA  
             Homo sapiens  
           
            112 

caaccaataa actcccaccc c                                               21 

 
           
             113  
             21  
             DNA  
             Homo sapiens  
           
            113 

aaccaataat atcccacccc a                                               21 

 
           
             114  
             21  
             DNA  
             Homo sapiens  
           
            114 

accaataatc acccacccca c                                               21 

 
           
             115  
             21  
             DNA  
             Homo sapiens  
           
            115 

ccaataatct accaccccac c                                               21 

 
           
             116  
             21  
             DNA  
             Homo sapiens  
           
            116 

caataatctc acaccccacc t                                               21 

 
           
             117  
             21  
             DNA  
             Homo sapiens  
           
            117 

aataatctcc aaccccacct a                                               21 

 
           
             118  
             21  
             DNA  
             Homo sapiens  
           
            118 

ataatctccc accccaccta a                                               21 

 
           
             119  
             21  
             DNA  
             Homo sapiens  
           
            119 

taatctccca acccacctaa c                                               21 

 
           
             120  
             21  
             DNA  
             Homo sapiens  
           
            120 

aatctcccac accacctaac t                                               21 

 
           
             121  
             21  
             DNA  
             Homo sapiens  
           
            121 

atctcccacc acacctaact c                                               21 

 
           
             122  
             21  
             DNA  
             Homo sapiens  
           
            122 

tctcccaccc aacctaactc a                                               21 

 
           
             123  
             21  
             DNA  
             Homo sapiens  
           
            123 

ctcccacccc acctaactca c                                               21 

 
           
             124  
             21  
             DNA  
             Homo sapiens  
           
            124 

tcccacccca actaactcac a                                               21 

 
           
             125  
             21  
             DNA  
             Homo sapiens  
           
            125 

cccaccccac ataactcaca c                                               21 

 
           
             126  
             21  
             DNA  
             Homo sapiens  
           
            126 

ccaccccacc aaactcacac a                                               21 

 
           
             127  
             21  
             DNA  
             Homo sapiens  
           
            127 

caccccacct aactcacaca a                                               21 

 
           
             128  
             21  
             DNA  
             Homo sapiens  
           
            128 

accccaccta actcacacaa a                                               21 

 
           
             129  
             21  
             DNA  
             Homo sapiens  
           
            129 

ccccacctaa atcacacaaa c                                               21 

 
           
             130  
             21  
             DNA  
             Homo sapiens  
           
            130 

cccacctaac acacacaaac c                                               21 

 
           
             131  
             21  
             DNA  
             Homo sapiens  
           
            131 

ccacctaact aacacaaacc a                                               21 

 
           
             132  
             21  
             DNA  
             Homo sapiens  
           
            132 

cacctaactc acacaaacca c                                               21 

 
           
             133  
             21  
             DNA  
             Homo sapiens  
           
            133 

acctaactca aacaaaccac c                                               21 

 
           
             134  
             20  
             DNA  
             Homo sapiens  
           
            134 

tacattgccc atgtaattaa                                                 20 

 
           
             135  
             20  
             DNA  
             Homo sapiens  
           
            135 

atatagtttc gtcattcatc                                                 20 

 
           
             136  
             20  
             DNA  
             Homo sapiens  
           
            136 

tacattgccc atgtaattaa                                                 20 

 
           
             137  
             20  
             DNA  
             Homo sapiens  
           
            137 

atatagtttc gtcattcatc                                                 20 

 
           
             138  
             20  
             DNA  
             Homo sapiens  
           
            138 

agatagttta gtcattcatc                                                 20 

 
           
             139  
             20  
             DNA  
             Homo sapiens  
           
            139 

agatagtttc atcattcatc                                                 20 

 
           
             140  
             20  
             DNA  
             Homo sapiens  
           
            140 

agatagtttc gacattcatc                                                 20 

 
           
             141  
             20  
             DNA  
             Homo sapiens  
           
            141 

agatagtttc gtaattcatc                                                 20 

 
           
             142  
             21  
             DNA  
             Homo sapiens  
           
            142 

cctaactcac acaaaccacc a                                               21 

 
           
             143  
             21  
             DNA  
             Homo sapiens  
           
            143 

ctaactcaca aaaaccacca a                                               21 

 
           
             144  
             21  
             DNA  
             Homo sapiens  
           
            144 

taactcacac aaaccaccaa c                                               21 

 
           
             145  
             21  
             DNA  
             Homo sapiens  
           
            145 

aactcacaca taccaccaac a                                               21 

 
           
             146  
             21  
             DNA  
             Homo sapiens  
           
            146 

actcacacaa tccaccaaca c                                               21 

 
           
             147  
             21  
             DNA  
             Homo sapiens  
           
            147 

ctcacacaaa tcaccaacac c                                               21 

 
           
             148  
             21  
             DNA  
             Homo sapiens  
           
            148 

tcacacaaac taccaacacc t                                               21 

 
           
             149  
             21  
             DNA  
             Homo sapiens  
           
            149 

cacacaaacc tccaacacct c                                               21 

 
           
             150  
             21  
             DNA  
             Homo sapiens  
           
            150 

acacaaacca tcaacacctc t                                               21 

 
           
             151  
             21  
             DNA  
             Homo sapiens  
           
            151 

cacaaaccac taacacctct c                                               21 

 
           
             152  
             21  
             DNA  
             Homo sapiens  
           
            152 

acaaaccacc tacacctctc c                                               21 

 
           
             153  
             21  
             DNA  
             Homo sapiens  
           
            153 

caaaccacca tcacctctcc c                                               21 

 
           
             154  
             21  
             DNA  
             Homo sapiens  
           
            154 

aaaccaccaa tacctctccc c                                               21 

 
           
             155  
             21  
             DNA  
             Homo sapiens  
           
            155 

aaccaccaac tcctctcccc c                                               21 

 
           
             156  
             21  
             DNA  
             Homo sapiens  
           
            156 

accaccaaca tctctccccc t                                               21 

 
           
             157  
             21  
             DNA  
             Homo sapiens  
           
            157 

ccaccaacac ttctccccct c                                               21 

 
           
             158  
             21  
             DNA  
             Homo sapiens  
           
            158 

caccaacacc tctccccctc t                                               21 

 
           
             159  
             21  
             DNA  
             Homo sapiens  
           
            159 

accaacacct ttccccctct c                                               21 

 
           
             160  
             21  
             DNA  
             Homo sapiens  
           
            160 

ccaacacctc tccccctctc a                                               21 

 
           
             161  
             21  
             DNA  
             Homo sapiens  
           
            161 

caacacctct tcccctctca t                                               21 

 
           
             162  
             21  
             DNA  
             Homo sapiens  
           
            162 

aacacctctc tccctctcat c                                               21 

 
           
             163  
             21  
             DNA  
             Homo sapiens  
           
            163 

acacctctcc tcctctcatc c                                               21 

 
           
             164  
             21  
             DNA  
             Homo sapiens  
           
            164 

cacctctccc tctctcatcc a                                               21 

 
           
             165  
             21  
             DNA  
             Homo sapiens  
           
            165 

acctctcccc ttctcatcca t                                               21 

 
           
             166  
             21  
             DNA  
             Homo sapiens  
           
            166 

cctctccccc tctcatccat c                                               21 

 
           
             167  
             20  
             DNA  
             Homo sapiens  
           
            167 

atatagtttc gtcattcatc                                                 20 

 
           
             168  
             20  
             DNA  
             Homo sapiens  
           
            168 

tacattgccc atgtaattaa                                                 20 

 
           
             169  
             20  
             DNA  
             Homo sapiens  
           
            169 

atatagtttc gtcattcatc                                                 20 

 
           
             170  
             20  
             DNA  
             Homo sapiens  
           
            170 

tacattgccc atgtaattaa                                                 20 

 
           
             171  
             20  
             DNA  
             Homo sapiens  
           
            171 

agatagtttt gtcattcatc                                                 20 

 
           
             172  
             20  
             DNA  
             Homo sapiens  
           
            172 

agatagtttc ttcattcatc                                                 20 

 
           
             173  
             20  
             DNA  
             Homo sapiens  
           
            173 

agatagtttc gtcattcatc                                                 20 

 
           
             174  
             20  
             DNA  
             Homo sapiens  
           
            174 

agatagtttc gttattcatc                                                 20 

 
           
             175  
             21  
             DNA  
             Homo sapiens  
           
            175 

ctctccccct ttcatccatc a                                               21 

 
           
             176  
             21  
             DNA  
             Homo sapiens  
           
            176 

tctccccctc tcatccatca c                                               21 

 
           
             177  
             21  
             DNA  
             Homo sapiens  
           
            177 

ctccccctct tatccatcac c                                               21 

 
           
             178  
             21  
             DNA  
             Homo sapiens  
           
            178 

tccccctctc ttccatcacc c                                               21 

 
           
             179  
             21  
             DNA  
             Homo sapiens  
           
            179 

ccccctctca tccatcaccc a                                               21 

 
           
             180  
             21  
             DNA  
             Homo sapiens  
           
            180 

cccctctcat tcatcaccca c                                               21 

 
           
             181  
             21  
             DNA  
             Homo sapiens  
           
            181 

aactcacaca gaccaccaac a                                               21 

 
           
             182  
             21  
             DNA  
             Homo sapiens  
           
            182 

actcacacaa gccaccaaca c                                               21 

 
           
             183  
             21  
             DNA  
             Homo sapiens  
           
            183 

ctcacacaaa gcaccaacac c                                               21 

 
           
             184  
             21  
             DNA  
             Homo sapiens  
           
            184 

tcacacaaac gaccaacacc t                                               21 

 
           
             185  
             21  
             DNA  
             Homo sapiens  
           
            185 

cacacaaacc gccaacacct c                                               21 

 
           
             186  
             21  
             DNA  
             Homo sapiens  
           
            186 

acacaaacca gcaacacctc t                                               21 

 
           
             187  
             21  
             DNA  
             Homo sapiens  
           
            187 

cacaaaccac gaacacctct c                                               21 

 
           
             188  
             21  
             DNA  
             Homo sapiens  
           
            188 

acaaaccacc gacacctctc c                                               21 

 
           
             189  
             21  
             DNA  
             Homo sapiens  
           
            189 

caaaccacca gcacctctcc c                                               21 

 
           
             190  
             21  
             DNA  
             Homo sapiens  
           
            190 

aaaccaccaa gacctctccc c                                               21 

 
           
             191  
             21  
             DNA  
             Homo sapiens  
           
            191 

aaccaccaac gcctctcccc c                                               21 

 
           
             192  
             21  
             DNA  
             Homo sapiens  
           
            192 

accaccaaca gctctccccc t                                               21 

 
           
             193  
             21  
             DNA  
             Homo sapiens  
           
            193 

ccaccaacac gtctccccct c                                               21 

 
           
             194  
             21  
             DNA  
             Homo sapiens  
           
            194 

caccaacacc gctccccctc t                                               21 

 
           
             195  
             21  
             DNA  
             Homo sapiens  
           
            195 

accaacacct gtccccctct c                                               21 

 
           
             196  
             21  
             DNA  
             Homo sapiens  
           
            196 

ccaacacctc gccccctctc a                                               21 

 
           
             197  
             21  
             DNA  
             Homo sapiens  
           
            197 

caacacctct gcccctctca t                                               21 

 
           
             198  
             21  
             DNA  
             Homo sapiens  
           
            198 

aacacctctc gccctctcat c                                               21 

 
           
             199  
             21  
             DNA  
             Homo sapiens  
           
            199 

acacctctcc gcctctcatc c                                               21 

 
           
             200  
             21  
             DNA  
             Homo sapiens  
           
            200 

cacctctccc gctctcatcc a                                               21 

 
           
             201  
             21  
             DNA  
             Homo sapiens  
           
            201 

acctctcccc gtctcatcca t                                               21 

 
           
             202  
             21  
             DNA  
             Homo sapiens  
           
            202 

cctctccccc gctcatccat c                                               21 

 
           
             203  
             20  
             DNA  
             Homo sapiens  
           
            203 

tacattgccc atgtaattaa                                                 20 

 
           
             204  
             20  
             DNA  
             Homo sapiens  
           
            204 

atatagtttc gtcattcatc                                                 20 

 
           
             205  
             20  
             DNA  
             Homo sapiens  
           
            205 

tacattgccc atgtaattaa                                                 20 

 
           
             206  
             20  
             DNA  
             Homo sapiens  
           
            206 

atatagtttc gtcattcatc                                                 20 

 
           
             207  
             20  
             DNA  
             Homo sapiens  
           
            207 

agatagtttg gtcattcatc                                                 20 

 
           
             208  
             20  
             DNA  
             Homo sapiens  
           
            208 

agatagtttc gtcattcatc                                                 20 

 
           
             209  
             20  
             DNA  
             Homo sapiens  
           
            209 

agatagtttc ggcattcatc                                                 20 

 
           
             210  
             20  
             DNA  
             Homo sapiens  
           
            210 

agatagtttc gtgattcatc                                                 20 

 
           
             211  
             21  
             DNA  
             Homo sapiens  
           
            211 

ctctccccct gtcatccatc a                                               21 

 
           
             212  
             21  
             DNA  
             Homo sapiens  
           
            212 

tctccccctc gcatccatca c                                               21 

 
           
             213  
             21  
             DNA  
             Homo sapiens  
           
            213 

ctccccctct gatccatcac c                                               21 

 
           
             214  
             21  
             DNA  
             Homo sapiens  
           
            214 

tccccctctc gtccatcacc c                                               21 

 
           
             215  
             21  
             DNA  
             Homo sapiens  
           
            215 

ccccctctca gccatcaccc a                                               21 

 
           
             216  
             21  
             DNA  
             Homo sapiens  
           
            216 

cccctctcat gcatcaccca c                                               21 

 
           
             217  
             21  
             DNA  
             Homo sapiens  
           
            217 

aactcacaca caccaccaac a                                               21 

 
           
             218  
             21  
             DNA  
             Homo sapiens  
           
            218 

actcacacaa cccaccaaca c                                               21 

 
           
             219  
             21  
             DNA  
             Homo sapiens  
           
            219 

ctcacacaaa ccaccaacac c                                               21 

 
           
             220  
             21  
             DNA  
             Homo sapiens  
           
            220 

tcacacaaac caccaacacc t                                               21 

 
           
             221  
             21  
             DNA  
             Homo sapiens  
           
            221 

cacacaaacc cccaacacct c                                               21 

 
           
             222  
             21  
             DNA  
             Homo sapiens  
           
            222 

acacaaacca ccaacacctc t                                               21 

 
           
             223  
             21  
             DNA  
             Homo sapiens  
           
            223 

cacaaaccac caacacctct c                                               21 

 
           
             224  
             21  
             DNA  
             Homo sapiens  
           
            224 

acaaaccacc cacacctctc c                                               21 

 
           
             225  
             21  
             DNA  
             Homo sapiens  
           
            225 

caaaccacca ccacctctcc c                                               21 

 
           
             226  
             21  
             DNA  
             Homo sapiens  
           
            226 

aaaccaccaa cacctctccc c                                               21 

 
           
             227  
             21  
             DNA  
             Homo sapiens  
           
            227 

aaccaccaac ccctctcccc c                                               21 

 
           
             228  
             21  
             DNA  
             Homo sapiens  
           
            228 

accaccaaca cctctccccc t                                               21 

 
           
             229  
             21  
             DNA  
             Homo sapiens  
           
            229 

ccaccaacac ctctccccct c                                               21 

 
           
             230  
             21  
             DNA  
             Homo sapiens  
           
            230 

caccaacacc cctccccctc t                                               21 

 
           
             231  
             21  
             DNA  
             Homo sapiens  
           
            231 

accaacacct ctccccctct c                                               21 

 
           
             232  
             21  
             DNA  
             Homo sapiens  
           
            232 

ccaacacctc cccccctctc a                                               21 

 
           
             233  
             21  
             DNA  
             Homo sapiens  
           
            233 

caacacctct ccccctctca t                                               21 

 
           
             234  
             21  
             DNA  
             Homo sapiens  
           
            234 

aacacctctc cccctctcat c                                               21 

 
           
             235  
             21  
             DNA  
             Homo sapiens  
           
            235 

acacctctcc ccctctcatc c                                               21 

 
           
             236  
             21  
             DNA  
             Homo sapiens  
           
            236 

cacctctccc cctctcatcc a                                               21 

 
           
             237  
             21  
             DNA  
             Homo sapiens  
           
            237 

acctctcccc ctctcatcca t                                               21 

 
           
             238  
             21  
             DNA  
             Homo sapiens  
           
            238 

cctctccccc cctcatccat c                                               21 

 
           
             239  
             20  
             DNA  
             Homo sapiens  
           
            239 

atatagtttc gtcattcatc                                                 20 

 
           
             240  
             20  
             DNA  
             Homo sapiens  
           
            240 

tacattgccc atgtaattaa                                                 20 

 
           
             241  
             20  
             DNA  
             Homo sapiens  
           
            241 

atatagtttc gtcattcatc                                                 20 

 
           
             242  
             20  
             DNA  
             Homo sapiens  
           
            242 

tacattgccc atgtaattaa                                                 20 

 
           
             243  
             20  
             DNA  
             Homo sapiens  
           
            243 

agatagtttc gtcattcatc                                                 20 

 
           
             244  
             20  
             DNA  
             Homo sapiens  
           
            244 

agatagtttc ctcattcatc                                                 20 

 
           
             245  
             20  
             DNA  
             Homo sapiens  
           
            245 

agatagtttc gccattcatc                                                 20 

 
           
             246  
             20  
             DNA  
             Homo sapiens  
           
            246 

agatagtttc gtcattcatc                                                 20 

 
           
             247  
             21  
             DNA  
             Homo sapiens  
           
            247 

ctctccccct ctcatccatc a                                               21 

 
           
             248  
             21  
             DNA  
             Homo sapiens  
           
            248 

tctccccctc ccatccatca c                                               21 

 
           
             249  
             21  
             DNA  
             Homo sapiens  
           
            249 

ctccccctct catccatcac c                                               21 

 
           
             250  
             21  
             DNA  
             Homo sapiens  
           
            250 

tccccctctc ctccatcacc c                                               21 

 
           
             251  
             21  
             DNA  
             Homo sapiens  
           
            251 

ccccctctca cccatcaccc a                                               21 

 
           
             252  
             21  
             DNA  
             Homo sapiens  
           
            252 

cccctctcat ccatcaccca c                                               21 

 
           
             253  
             21  
             DNA  
             Homo sapiens  
           
            253 

aactcacaca aaccaccaac a                                               21 

 
           
             254  
             21  
             DNA  
             Homo sapiens  
           
            254 

actcacacaa accaccaaca c                                               21 

 
           
             255  
             21  
             DNA  
             Homo sapiens  
           
            255 

ctcacacaaa acaccaacac c                                               21 

 
           
             256  
             21  
             DNA  
             Homo sapiens  
           
            256 

tcacacaaac aaccaacacc t                                               21 

 
           
             257  
             21  
             DNA  
             Homo sapiens  
           
            257 

cacacaaacc accaacacct c                                               21 

 
           
             258  
             21  
             DNA  
             Homo sapiens  
           
            258 

acacaaacca acaacacctc t                                               21 

 
           
             259  
             21  
             DNA  
             Homo sapiens  
           
            259 

cacaaaccac aaacacctct c                                               21 

 
           
             260  
             21  
             DNA  
             Homo sapiens  
           
            260 

acaaaccacc aacacctctc c                                               21 

 
           
             261  
             21  
             DNA  
             Homo sapiens  
           
            261 

caaaccacca acacctctcc c                                               21 

 
           
             262  
             21  
             DNA  
             Homo sapiens  
           
            262 

aaaccaccaa aacctctccc c                                               21 

 
           
             263  
             21  
             DNA  
             Homo sapiens  
           
            263 

aaccaccaac acctctcccc c                                               21 

 
           
             264  
             21  
             DNA  
             Homo sapiens  
           
            264 

accaccaaca actctccccc t                                               21 

 
           
             265  
             21  
             DNA  
             Homo sapiens  
           
            265 

ccaccaacac atctccccct c                                               21 

 
           
             266  
             21  
             DNA  
             Homo sapiens  
           
            266 

caccaacacc actccccctc t                                               21 

 
           
             267  
             21  
             DNA  
             Homo sapiens  
           
            267 

accaacacct atccccctct c                                               21 

 
           
             268  
             21  
             DNA  
             Homo sapiens  
           
            268 

ccaacacctc accccctctc a                                               21 

 
           
             269  
             21  
             DNA  
             Homo sapiens  
           
            269 

caacacctct acccctctca t                                               21 

 
           
             270  
             21  
             DNA  
             Homo sapiens  
           
            270 

aacacctctc accctctcat c                                               21 

 
           
             271  
             21  
             DNA  
             Homo sapiens  
           
            271 

acacctctcc acctctcatc c                                               21 

 
           
             272  
             21  
             DNA  
             Homo sapiens  
           
            272 

cacctctccc actctcatcc a                                               21 

 
           
             273  
             21  
             DNA  
             Homo sapiens  
           
            273 

acctctcccc atctcatcca t                                               21 

 
           
             274  
             21  
             DNA  
             Homo sapiens  
           
            274 

cctctccccc actcatccat c                                               21 

 
           
             275  
             20  
             DNA  
             Homo sapiens  
           
            275 

tacattgccc atgtaattaa                                                 20 

 
           
             276  
             20  
             DNA  
             Homo sapiens  
           
            276 

atatagtttc gtcattcatc                                                 20 

 
           
             277  
             20  
             DNA  
             Homo sapiens  
           
            277 

tacattgccc atgtaattaa                                                 20 

 
           
             278  
             20  
             DNA  
             Homo sapiens  
           
            278 

atatagtttc gtcattcatc                                                 20 

 
           
             279  
             20  
             DNA  
             Homo sapiens  
           
            279 

agatagttta gtcattcatc                                                 20 

 
           
             280  
             20  
             DNA  
             Homo sapiens  
           
            280 

agatagtttc atcattcatc                                                 20 

 
           
             281  
             20  
             DNA  
             Homo sapiens  
           
            281 

agatagtttc gacattcatc                                                 20 

 
           
             282  
             20  
             DNA  
             Homo sapiens  
           
            282 

agatagtttc gtaattcatc                                                 20 

 
           
             283  
             21  
             DNA  
             Homo sapiens  
           
            283 

ctctccccct atcatccatc a                                               21 

 
           
             284  
             21  
             DNA  
             Homo sapiens  
           
            284 

tctccccctc acatccatca c                                               21 

 
           
             285  
             21  
             DNA  
             Homo sapiens  
           
            285 

ctccccctct aatccatcac c                                               21 

 
           
             286  
             21  
             DNA  
             Homo sapiens  
           
            286 

tccccctctc atccatcacc c                                               21 

 
           
             287  
             21  
             DNA  
             Homo sapiens  
           
            287 

ccccctctca accatcaccc a                                               21 

 
           
             288  
             21  
             DNA  
             Homo sapiens  
           
            288 

cccctctcat acatcaccca c                                               21 

 
           
             289  
             21  
             DNA  
             Homo sapiens  
           
            289 

ccctctcatc tatcacccac c                                               21 

 
           
             290  
             21  
             DNA  
             Homo sapiens  
           
            290 

cctctcatcc ttcacccacc a                                               21 

 
           
             291  
             21  
             DNA  
             Homo sapiens  
           
            291 

ctctcatcca tcacccacca c                                               21 

 
           
             292  
             21  
             DNA  
             Homo sapiens  
           
            292 

tctcatccat tacccaccac c                                               21 

 
           
             293  
             21  
             DNA  
             Homo sapiens  
           
            293 

ctcatccatc tcccaccacc c                                               21 

 
           
             294  
             21  
             DNA  
             Homo sapiens  
           
            294 

tcatccatca tccaccaccc c                                               21 

 
           
             295  
             21  
             DNA  
             Homo sapiens  
           
            295 

catccatcac tcaccacccc t                                               21 

 
           
             296  
             21  
             DNA  
             Homo sapiens  
           
            296 

atccatcacc taccacccct c                                               21 

 
           
             297  
             21  
             DNA  
             Homo sapiens  
           
            297 

tccatcaccc tccacccctc a                                               21 

 
           
             298  
             21  
             DNA  
             Homo sapiens  
           
            298 

ccatcaccca tcacccctca t                                               21 

 
           
             299  
             21  
             DNA  
             Homo sapiens  
           
            299 

catcacccac tacccctcat c                                               21 

 
           
             300  
             21  
             DNA  
             Homo sapiens  
           
            300 

atcacccacc tcccctcatc a                                               21 

 
           
             301  
             21  
             DNA  
             Homo sapiens  
           
            301 

tcacccacca tccctcatca t                                               21 

 
           
             302  
             21  
             DNA  
             Homo sapiens  
           
            302 

cacccaccac tcctcatcat a                                               21 

 
           
             303  
             21  
             DNA  
             Homo sapiens  
           
            303 

acccaccacc tctcatcata c                                               21 

 
           
             304  
             21  
             DNA  
             Homo sapiens  
           
            304 

cccaccaccc ttcatcatac c                                               21 

 
           
             305  
             21  
             DNA  
             Homo sapiens  
           
            305 

ccaccacccc tcatcatacc t                                               21 

 
           
             306  
             21  
             DNA  
             Homo sapiens  
           
            306 

caccacccct tatcatacct c                                               21 

 
           
             307  
             21  
             DNA  
             Homo sapiens  
           
            307 

accacccctc ttcatacctc a                                               21 

 
           
             308  
             20  
             DNA  
             Homo sapiens  
           
            308 

atatagtttc gtcattcatc                                                 20 

 
           
             309  
             20  
             DNA  
             Homo sapiens  
           
            309 

tacattgccc atgtaattaa                                                 20 

 
           
             310  
             20  
             DNA  
             Homo sapiens  
           
            310 

atatagtttc gtcattcatc                                                 20 

 
           
             311  
             20  
             DNA  
             Homo sapiens  
           
            311 

tacattgccc atgtaattaa                                                 20 

 
           
             312  
             20  
             DNA  
             Homo sapiens  
           
            312 

agatagtttt gtcattcatc                                                 20 

 
           
             313  
             20  
             DNA  
             Homo sapiens  
           
            313 

agatagtttc ttcattcatc                                                 20 

 
           
             314  
             20  
             DNA  
             Homo sapiens  
           
            314 

agatagtttc gtcattcatc                                                 20 

 
           
             315  
             20  
             DNA  
             Homo sapiens  
           
            315 

agatagtttc gttattcatc                                                 20 

 
           
             316  
             21  
             DNA  
             Homo sapiens  
           
            316 

ccacccctca tcatacctca a                                               21 

 
           
             317  
             21  
             DNA  
             Homo sapiens  
           
            317 

cacccctcat tatacctcaa c                                               21 

 
           
             318  
             21  
             DNA  
             Homo sapiens  
           
            318 

acccctcatc ttacctcaac c                                               21 

 
           
             319  
             21  
             DNA  
             Homo sapiens  
           
            319 

cccctcatca tacctcaacc a                                               21 

 
           
             320  
             21  
             DNA  
             Homo sapiens  
           
            320 

ccctcatcat tcctcaacca c                                               21 

 
           
             321  
             21  
             DNA  
             Homo sapiens  
           
            321 

cctcatcata tctcaaccac c                                               21 

 
           
             322  
             21  
             DNA  
             Homo sapiens  
           
            322 

ctcatcatac ttcaaccacc a                                               21 

 
           
             323  
             21  
             DNA  
             Homo sapiens  
           
            323 

tcatcatacc tcaaccacca c                                               21 

 
           
             324  
             21  
             DNA  
             Homo sapiens  
           
            324 

catcatacct taaccaccac c                                               21 

 
           
             325  
             21  
             DNA  
             Homo sapiens  
           
            325 

ccctctcatc gatcacccac c                                               21 

 
           
             326  
             21  
             DNA  
             Homo sapiens  
           
            326 

cctctcatcc gtcacccacc a                                               21 

 
           
             327  
             21  
             DNA  
             Homo sapiens  
           
            327 

ctctcatcca gcacccacca c                                               21 

 
           
             328  
             21  
             DNA  
             Homo sapiens  
           
            328 

tctcatccat gacccaccac c                                               21 

 
           
             329  
             21  
             DNA  
             Homo sapiens  
           
            329 

ctcatccatc gcccaccacc c                                               21 

 
           
             330  
             21  
             DNA  
             Homo sapiens  
           
            330 

tcatccatca gccaccaccc c                                               21 

 
           
             331  
             21  
             DNA  
             Homo sapiens  
           
            331 

catccatcac gcaccacccc t                                               21 

 
           
             332  
             21  
             DNA  
             Homo sapiens  
           
            332 

atccatcacc gaccacccct c                                               21 

 
           
             333  
             21  
             DNA  
             Homo sapiens  
           
            333 

tccatcaccc gccacccctc a                                               21 

 
           
             334  
             21  
             DNA  
             Homo sapiens  
           
            334 

ccatcaccca gcacccctca t                                               21 

 
           
             335  
             21  
             DNA  
             Homo sapiens  
           
            335 

catcacccac gacccctcat c                                               21 

 
           
             336  
             21  
             DNA  
             Homo sapiens  
           
            336 

atcacccacc gcccctcatc a                                               21 

 
           
             337  
             21  
             DNA  
             Homo sapiens  
           
            337 

tcacccacca gccctcatca t                                               21 

 
           
             338  
             21  
             DNA  
             Homo sapiens  
           
            338 

cacccaccac gcctcatcat a                                               21 

 
           
             339  
             21  
             DNA  
             Homo sapiens  
           
            339 

acccaccacc gctcatcata c                                               21 

 
           
             340  
             21  
             DNA  
             Homo sapiens  
           
            340 

cccaccaccc gtcatcatac c                                               21 

 
           
             341  
             21  
             DNA  
             Homo sapiens  
           
            341 

ccaccacccc gcatcatacc t                                               21 

 
           
             342  
             21  
             DNA  
             Homo sapiens  
           
            342 

caccacccct gatcatacct c                                               21 

 
           
             343  
             21  
             DNA  
             Homo sapiens  
           
            343 

accacccctc gtcatacctc a                                               21 

 
           
             344  
             20  
             DNA  
             Homo sapiens  
           
            344 

tacattgccc atgtaattaa                                                 20 

 
           
             345  
             20  
             DNA  
             Homo sapiens  
           
            345 

atatagtttc gtcattcatc                                                 20 

 
           
             346  
             20  
             DNA  
             Homo sapiens  
           
            346 

tacattgccc atgtaattaa                                                 20 

 
           
             347  
             20  
             DNA  
             Homo sapiens  
           
            347 

atatagtttc gtcattcatc                                                 20 

 
           
             348  
             20  
             DNA  
             Homo sapiens  
           
            348 

agatagtttg gtcattcatc                                                 20 

 
           
             349  
             20  
             DNA  
             Homo sapiens  
           
            349 

agatagtttc gtcattcatc                                                 20 

 
           
             350  
             20  
             DNA  
             Homo sapiens  
           
            350 

agatagtttc ggcattcatc                                                 20 

 
           
             351  
             20  
             DNA  
             Homo sapiens  
           
            351 

agatagtttc gtgattcatc                                                 20 

 
           
             352  
             21  
             DNA  
             Homo sapiens  
           
            352 

ccacccctca gcatacctca a                                               21 

 
           
             353  
             21  
             DNA  
             Homo sapiens  
           
            353 

cacccctcat gatacctcaa c                                               21 

 
           
             354  
             21  
             DNA  
             Homo sapiens  
           
            354 

acccctcatc gtacctcaac c                                               21 

 
           
             355  
             21  
             DNA  
             Homo sapiens  
           
            355 

cccctcatca gacctcaacc a                                               21 

 
           
             356  
             21  
             DNA  
             Homo sapiens  
           
            356 

ccctcatcat gcctcaacca c                                               21 

 
           
             357  
             21  
             DNA  
             Homo sapiens  
           
            357 

cctcatcata gctcaaccac c                                               21 

 
           
             358  
             21  
             DNA  
             Homo sapiens  
           
            358 

ctcatcatac gtcaaccacc a                                               21 

 
           
             359  
             21  
             DNA  
             Homo sapiens  
           
            359 

tcatcatacc gcaaccacca c                                               21 

 
           
             360  
             21  
             DNA  
             Homo sapiens  
           
            360 

catcatacct gaaccaccac c                                               21 

 
           
             361  
             21  
             DNA  
             Homo sapiens  
           
            361 

ccctctcatc catcacccac c                                               21 

 
           
             362  
             21  
             DNA  
             Homo sapiens  
           
            362 

cctctcatcc ctcacccacc a                                               21 

 
           
             363  
             21  
             DNA  
             Homo sapiens  
           
            363 

ctctcatcca ccacccacca c                                               21 

 
           
             364  
             21  
             DNA  
             Homo sapiens  
           
            364 

tctcatccat cacccaccac c                                               21 

 
           
             365  
             21  
             DNA  
             Homo sapiens  
           
            365 

ctcatccatc ccccaccacc c                                               21 

 
           
             366  
             21  
             DNA  
             Homo sapiens  
           
            366 

tcatccatca cccaccaccc c                                               21 

 
           
             367  
             21  
             DNA  
             Homo sapiens  
           
            367 

catccatcac ccaccacccc t                                               21 

 
           
             368  
             21  
             DNA  
             Homo sapiens  
           
            368 

atccatcacc caccacccct c                                               21 

 
           
             369  
             21  
             DNA  
             Homo sapiens  
           
            369 

tccatcaccc cccacccctc a                                               21 

 
           
             370  
             21  
             DNA  
             Homo sapiens  
           
            370 

ccatcaccca ccacccctca t                                               21 

 
           
             371  
             21  
             DNA  
             Homo sapiens  
           
            371 

catcacccac cacccctcat c                                               21 

 
           
             372  
             21  
             DNA  
             Homo sapiens  
           
            372 

atcacccacc ccccctcatc a                                               21 

 
           
             373  
             21  
             DNA  
             Homo sapiens  
           
            373 

tcacccacca cccctcatca t                                               21 

 
           
             374  
             21  
             DNA  
             Homo sapiens  
           
            374 

cacccaccac ccctcatcat a                                               21 

 
           
             375  
             21  
             DNA  
             Homo sapiens  
           
            375 

acccaccacc cctcatcata c                                               21 

 
           
             376  
             21  
             DNA  
             Homo sapiens  
           
            376 

cccaccaccc ctcatcatac c                                               21 

 
           
             377  
             21  
             DNA  
             Homo sapiens  
           
            377 

ccaccacccc ccatcatacc t                                               21 

 
           
             378  
             21  
             DNA  
             Homo sapiens  
           
            378 

caccacccct catcatacct c                                               21 

 
           
             379  
             21  
             DNA  
             Homo sapiens  
           
            379 

accacccctc ctcatacctc a                                               21 

 
           
             380  
             20  
             DNA  
             Homo sapiens  
           
            380 

atatagtttc gtcattcatc                                                 20 

 
           
             381  
             20  
             DNA  
             Homo sapiens  
           
            381 

tacattgccc atgtaattaa                                                 20 

 
           
             382  
             20  
             DNA  
             Homo sapiens  
           
            382 

atatagtttc gtcattcatc                                                 20 

 
           
             383  
             20  
             DNA  
             Homo sapiens  
           
            383 

tacattgccc atgtaattaa                                                 20 

 
           
             384  
             20  
             DNA  
             Homo sapiens  
           
            384 

agatagtttc gtcattcatc                                                 20 

 
           
             385  
             20  
             DNA  
             Homo sapiens  
           
            385 

agatagtttc ctcattcatc                                                 20 

 
           
             386  
             20  
             DNA  
             Homo sapiens  
           
            386 

agatagtttc gccattcatc                                                 20 

 
           
             387  
             20  
             DNA  
             Homo sapiens  
           
            387 

agatagtttc gtcattcatc                                                 20 

 
           
             388  
             21  
             DNA  
             Homo sapiens  
           
            388 

ccacccctca ccatacctca a                                               21 

 
           
             389  
             21  
             DNA  
             Homo sapiens  
           
            389 

cacccctcat catacctcaa c                                               21 

 
           
             390  
             21  
             DNA  
             Homo sapiens  
           
            390 

acccctcatc ctacctcaac c                                               21 

 
           
             391  
             21  
             DNA  
             Homo sapiens  
           
            391 

cccctcatca cacctcaacc a                                               21 

 
           
             392  
             21  
             DNA  
             Homo sapiens  
           
            392 

ccctcatcat ccctcaacca c                                               21 

 
           
             393  
             21  
             DNA  
             Homo sapiens  
           
            393 

cctcatcata cctcaaccac c                                               21 

 
           
             394  
             21  
             DNA  
             Homo sapiens  
           
            394 

ctcatcatac ctcaaccacc a                                               21 

 
           
             395  
             21  
             DNA  
             Homo sapiens  
           
            395 

tcatcatacc ccaaccacca c                                               21 

 
           
             396  
             21  
             DNA  
             Homo sapiens  
           
            396 

catcatacct caaccaccac c                                               21 

 
           
             397  
             21  
             DNA  
             Homo sapiens  
           
            397 

ccctctcatc aatcacccac c                                               21 

 
           
             398  
             21  
             DNA  
             Homo sapiens  
           
            398 

cctctcatcc atcacccacc a                                               21 

 
           
             399  
             21  
             DNA  
             Homo sapiens  
           
            399 

ctctcatcca acacccacca c                                               21 

 
           
             400  
             21  
             DNA  
             Homo sapiens  
           
            400 

tctcatccat aacccaccac c                                               21 

 
           
             401  
             21  
             DNA  
             Homo sapiens  
           
            401 

ctcatccatc acccaccacc c                                               21 

 
           
             402  
             21  
             DNA  
             Homo sapiens  
           
            402 

tcatccatca accaccaccc c                                               21 

 
           
             403  
             21  
             DNA  
             Homo sapiens  
           
            403 

catccatcac acaccacccc t                                               21 

 
           
             404  
             21  
             DNA  
             Homo sapiens  
           
            404 

atccatcacc aaccacccct c                                               21 

 
           
             405  
             21  
             DNA  
             Homo sapiens  
           
            405 

tccatcaccc accacccctc a                                               21 

 
           
             406  
             21  
             DNA  
             Homo sapiens  
           
            406 

ccatcaccca acacccctca t                                               21 

 
           
             407  
             21  
             DNA  
             Homo sapiens  
           
            407 

catcacccac aacccctcat c                                               21 

 
           
             408  
             21  
             DNA  
             Homo sapiens  
           
            408 

atcacccacc acccctcatc a                                               21 

 
           
             409  
             21  
             DNA  
             Homo sapiens  
           
            409 

tcacccacca accctcatca t                                               21 

 
           
             410  
             21  
             DNA  
             Homo sapiens  
           
            410 

cacccaccac acctcatcat a                                               21 

 
           
             411  
             21  
             DNA  
             Homo sapiens  
           
            411 

acccaccacc actcatcata c                                               21 

 
           
             412  
             21  
             DNA  
             Homo sapiens  
           
            412 

cccaccaccc atcatcatac c                                               21 

 
           
             413  
             21  
             DNA  
             Homo sapiens  
           
            413 

ccaccacccc acatcatacc t                                               21 

 
           
             414  
             21  
             DNA  
             Homo sapiens  
           
            414 

caccacccct aatcatacct c                                               21 

 
           
             415  
             21  
             DNA  
             Homo sapiens  
           
            415 

accacccctc atcatacctc a                                               21 

 
           
             416  
             20  
             DNA  
             Homo sapiens  
           
            416 

tacattgccc atgtaattaa                                                 20 

 
           
             417  
             20  
             DNA  
             Homo sapiens  
           
            417 

atatagtttc gtcattcatc                                                 20 

 
           
             418  
             20  
             DNA  
             Homo sapiens  
           
            418 

tacattgccc atgtaattaa                                                 20 

 
           
             419  
             20  
             DNA  
             Homo sapiens  
           
            419 

atatagtttc gtcattcatc                                                 20 

 
           
             420  
             20  
             DNA  
             Homo sapiens  
           
            420 

agatagttta gtcattcatc                                                 20 

 
           
             421  
             20  
             DNA  
             Homo sapiens  
           
            421 

agatagtttc atcattcatc                                                 20 

 
           
             422  
             20  
             DNA  
             Homo sapiens  
           
            422 

agatagtttc gacattcatc                                                 20 

 
           
             423  
             20  
             DNA  
             Homo sapiens  
           
            423 

agatagtttc gtaattcatc                                                 20 

 
           
             424  
             21  
             DNA  
             Homo sapiens  
           
            424 

ccacccctca acatacctca a                                               21 

 
           
             425  
             21  
             DNA  
             Homo sapiens  
           
            425 

cacccctcat aatacctcaa c                                               21 

 
           
             426  
             21  
             DNA  
             Homo sapiens  
           
            426 

acccctcatc atacctcaac c                                               21 

 
           
             427  
             21  
             DNA  
             Homo sapiens  
           
            427 

cccctcatca aacctcaacc a                                               21 

 
           
             428  
             21  
             DNA  
             Homo sapiens  
           
            428 

ccctcatcat acctcaacca c                                               21 

 
           
             429  
             21  
             DNA  
             Homo sapiens  
           
            429 

cctcatcata actcaaccac c                                               21 

 
           
             430  
             21  
             DNA  
             Homo sapiens  
           
            430 

ctcatcatac atcaaccacc a                                               21 

 
           
             431  
             21  
             DNA  
             Homo sapiens  
           
            431 

tcatcatacc acaaccacca c                                               21 

 
           
             432  
             21  
             DNA  
             Homo sapiens  
           
            432 

catcatacct aaaccaccac c                                               21 

 
           
             433  
             21  
             DNA  
             Homo sapiens  
           
            433 

atcatacctc taccaccacc c                                               21 

 
           
             434  
             21  
             DNA  
             Homo sapiens  
           
            434 

tcatacctca tccaccaccc c                                               21 

 
           
             435  
             21  
             DNA  
             Homo sapiens  
           
            435 

catacctcaa tcaccacccc t                                               21 

 
           
             436  
             21  
             DNA  
             Homo sapiens  
           
            436 

atacctcaac taccacccct c                                               21 

 
           
             437  
             21  
             DNA  
             Homo sapiens  
           
            437 

tacctcaacc tccacccctc a                                               21 

 
           
             438  
             21  
             DNA  
             Homo sapiens  
           
            438 

acctcaacca tcacccctca t                                               21 

 
           
             439  
             21  
             DNA  
             Homo sapiens  
           
            439 

cctcaaccac tacccctcat c                                               21 

 
           
             440  
             21  
             DNA  
             Homo sapiens  
           
            440 

ctcaaccacc tcccctcatc a                                               21 

 
           
             441  
             21  
             DNA  
             Homo sapiens  
           
            441 

tcaaccacca tccctcatca t                                               21 

 
           
             442  
             21  
             DNA  
             Homo sapiens  
           
            442 

caaccaccac tcctcatcat a                                               21 

 
           
             443  
             21  
             DNA  
             Homo sapiens  
           
            443 

aaccaccacc tctcatcata c                                               21 

 
           
             444  
             21  
             DNA  
             Homo sapiens  
           
            444 

accaccaccc ttcatcatac c                                               21 

 
           
             445  
             21  
             DNA  
             Homo sapiens  
           
            445 

ccaccacccc tcatcatacc t                                               21 

 
           
             446  
             21  
             DNA  
             Homo sapiens  
           
            446 

caccacccct tatcatacct c                                               21 

 
           
             447  
             21  
             DNA  
             Homo sapiens  
           
            447 

accacccctc ttcatacctc a                                               21 

 
           
             448  
             21  
             DNA  
             Homo sapiens  
           
            448 

ccacccctca tcatacctca a                                               21 

 
           
             449  
             20  
             DNA  
             Homo sapiens  
           
            449 

atatagtttc gtcattcatc                                                 20 

 
           
             450  
             20  
             DNA  
             Homo sapiens  
           
            450 

tacattgccc atgtaattaa                                                 20 

 
           
             451  
             20  
             DNA  
             Homo sapiens  
           
            451 

atatagtttc gtcattcatc                                                 20 

 
           
             452  
             20  
             DNA  
             Homo sapiens  
           
            452 

tacattgccc atgtaattaa                                                 20 

 
           
             453  
             20  
             DNA  
             Homo sapiens  
           
            453 

agatagtttt gtcattcatc                                                 20 

 
           
             454  
             20  
             DNA  
             Homo sapiens  
           
            454 

agatagtttc ttcattcatc                                                 20 

 
           
             455  
             20  
             DNA  
             Homo sapiens  
           
            455 

agatagtttc gtcattcatc                                                 20 

 
           
             456  
             20  
             DNA  
             Homo sapiens  
           
            456 

agatagtttc gttattcatc                                                 20 

 
           
             457  
             21  
             DNA  
             Homo sapiens  
           
            457 

cacccctcat tatacctcaa a                                               21 

 
           
             458  
             21  
             DNA  
             Homo sapiens  
           
            458 

acccctcatc ttacctcaaa a                                               21 

 
           
             459  
             21  
             DNA  
             Homo sapiens  
           
            459 

cccctcatca tacctcaaaa a                                               21 

 
           
             460  
             21  
             DNA  
             Homo sapiens  
           
            460 

ccctcatcat tcctcaaaaa c                                               21 

 
           
             461  
             21  
             DNA  
             Homo sapiens  
           
            461 

cctcatcata tctcaaaaac c                                               21 

 
           
             462  
             21  
             DNA  
             Homo sapiens  
           
            462 

ctcatcatac ttcaaaaacc a                                               21 

 
           
             463  
             21  
             DNA  
             Homo sapiens  
           
            463 

tcatcatacc tcaaaaacca a                                               21 

 
           
             464  
             21  
             DNA  
             Homo sapiens  
           
            464 

catcatacct taaaaaccaa c                                               21 

 
           
             465  
             21  
             DNA  
             Homo sapiens  
           
            465 

atcatacctc taaaaccaac t                                               21 

 
           
             466  
             21  
             DNA  
             Homo sapiens  
           
            466 

tcatacctca taaaccaact a                                               21 

 
           
             467  
             21  
             DNA  
             Homo sapiens  
           
            467 

catacctcaa taaccaacta a                                               21 

 
           
             468  
             21  
             DNA  
             Homo sapiens  
           
            468 

atacctcaaa taccaactaa c                                               21 

 
           
             469  
             21  
             DNA  
             Homo sapiens  
           
            469 

atcatacctc gaccaccacc c                                               21 

 
           
             470  
             21  
             DNA  
             Homo sapiens  
           
            470 

tcatacctca gccaccaccc c                                               21 

 
           
             471  
             21  
             DNA  
             Homo sapiens  
           
            471 

catacctcaa gcaccacccc t                                               21 

 
           
             472  
             21  
             DNA  
             Homo sapiens  
           
            472 

atacctcaac gaccacccct c                                               21 

 
           
             473  
             21  
             DNA  
             Homo sapiens  
           
            473 

tacctcaacc gccacccctc a                                               21 

 
           
             474  
             21  
             DNA  
             Homo sapiens  
           
            474 

acctcaacca gcacccctca t                                               21 

 
           
             475  
             21  
             DNA  
             Homo sapiens  
           
            475 

cctcaaccac gacccctcat c                                               21 

 
           
             476  
             21  
             DNA  
             Homo sapiens  
           
            476 

ctcaaccacc gcccctcatc a                                               21 

 
           
             477  
             21  
             DNA  
             Homo sapiens  
           
            477 

tcaaccacca gccctcatca t                                               21 

 
           
             478  
             21  
             DNA  
             Homo sapiens  
           
            478 

caaccaccac gcctcatcat a                                               21 

 
           
             479  
             21  
             DNA  
             Homo sapiens  
           
            479 

aaccaccacc gctcatcata c                                               21 

 
           
             480  
             21  
             DNA  
             Homo sapiens  
           
            480 

accaccaccc gtcatcatac c                                               21 

 
           
             481  
             21  
             DNA  
             Homo sapiens  
           
            481 

ccaccacccc gcatcatacc t                                               21 

 
           
             482  
             21  
             DNA  
             Homo sapiens  
           
            482 

caccacccct gatcatacct c                                               21 

 
           
             483  
             21  
             DNA  
             Homo sapiens  
           
            483 

accacccctc gtcatacctc a                                               21 

 
           
             484  
             21  
             DNA  
             Homo sapiens  
           
            484 

ccacccctca gcatacctca a                                               21 

 
           
             485  
             20  
             DNA  
             Homo sapiens  
           
            485 

tacattgccc atgtaattaa                                                 20 

 
           
             486  
             20  
             DNA  
             Homo sapiens  
           
            486 

atatagtttc gtcattcatc                                                 20 

 
           
             487  
             20  
             DNA  
             Homo sapiens  
           
            487 

tacattgccc atgtaattaa                                                 20 

 
           
             488  
             20  
             DNA  
             Homo sapiens  
           
            488 

atatagtttc gtcattcatc                                                 20 

 
           
             489  
             20  
             DNA  
             Homo sapiens  
           
            489 

agatagtttg gtcattcatc                                                 20 

 
           
             490  
             20  
             DNA  
             Homo sapiens  
           
            490 

agatagtttc gtcattcatc                                                 20 

 
           
             491  
             20  
             DNA  
             Homo sapiens  
           
            491 

agatagtttc ggcattcatc                                                 20 

 
           
             492  
             20  
             DNA  
             Homo sapiens  
           
            492 

agatagtttc gtgattcatc                                                 20 

 
           
             493  
             21  
             DNA  
             Homo sapiens  
           
            493 

cacccctcat gatacctcaa a                                               21 

 
           
             494  
             21  
             DNA  
             Homo sapiens  
           
            494 

acccctcatc gtacctcaaa a                                               21 

 
           
             495  
             21  
             DNA  
             Homo sapiens  
           
            495 

cccctcatca gacctcaaaa a                                               21 

 
           
             496  
             21  
             DNA  
             Homo sapiens  
           
            496 

ccctcatcat gcctcaaaaa c                                               21 

 
           
             497  
             21  
             DNA  
             Homo sapiens  
           
            497 

cctcatcata gctcaaaaac c                                               21 

 
           
             498  
             21  
             DNA  
             Homo sapiens  
           
            498 

ctcatcatac gtcaaaaacc a                                               21 

 
           
             499  
             21  
             DNA  
             Homo sapiens  
           
            499 

tcatcatacc gcaaaaacca a                                               21 

 
           
             500  
             21  
             DNA  
             Homo sapiens  
           
            500 

catcatacct gaaaaaccaa c                                               21 

 
           
             501  
             21  
             DNA  
             Homo sapiens  
           
            501 

atcatacctc gaaaaccaac t                                               21 

 
           
             502  
             21  
             DNA  
             Homo sapiens  
           
            502 

tcatacctca gaaaccaact a                                               21 

 
           
             503  
             21  
             DNA  
             Homo sapiens  
           
            503 

catacctcaa gaaccaacta a                                               21 

 
           
             504  
             21  
             DNA  
             Homo sapiens  
           
            504 

atacctcaaa gaccaactaa c                                               21 

 
           
             505  
             21  
             DNA  
             Homo sapiens  
           
            505 

atcatacctc caccaccacc c                                               21 

 
           
             506  
             21  
             DNA  
             Homo sapiens  
           
            506 

tcatacctca cccaccaccc c                                               21 

 
           
             507  
             21  
             DNA  
             Homo sapiens  
           
            507 

catacctcaa ccaccacccc t                                               21 

 
           
             508  
             21  
             DNA  
             Homo sapiens  
           
            508 

atacctcaac caccacccct c                                               21 

 
           
             509  
             21  
             DNA  
             Homo sapiens  
           
            509 

tacctcaacc cccacccctc a                                               21 

 
           
             510  
             21  
             DNA  
             Homo sapiens  
           
            510 

acctcaacca ccacccctca t                                               21 

 
           
             511  
             21  
             DNA  
             Homo sapiens  
           
            511 

cctcaaccac cacccctcat c                                               21 

 
           
             512  
             21  
             DNA  
             Homo sapiens  
           
            512 

ctcaaccacc ccccctcatc a                                               21 

 
           
             513  
             21  
             DNA  
             Homo sapiens  
           
            513 

tcaaccacca cccctcatca t                                               21 

 
           
             514  
             21  
             DNA  
             Homo sapiens  
           
            514 

caaccaccac ccctcatcat a                                               21 

 
           
             515  
             21  
             DNA  
             Homo sapiens  
           
            515 

aaccaccacc cctcatcata c                                               21 

 
           
             516  
             21  
             DNA  
             Homo sapiens  
           
            516 

accaccaccc ctcatcatac c                                               21 

 
           
             517  
             21  
             DNA  
             Homo sapiens  
           
            517 

ccaccacccc ccatcatacc t                                               21 

 
           
             518  
             21  
             DNA  
             Homo sapiens  
           
            518 

caccacccct catcatacct c                                               21 

 
           
             519  
             21  
             DNA  
             Homo sapiens  
           
            519 

accacccctc ctcatacctc a                                               21 

 
           
             520  
             21  
             DNA  
             Homo sapiens  
           
            520 

ccacccctca ccatacctca a                                               21 

 
           
             521  
             20  
             DNA  
             Homo sapiens  
           
            521 

atatagtttc gtcattcatc                                                 20 

 
           
             522  
             20  
             DNA  
             Homo sapiens  
           
            522 

tacattgccc atgtaattaa                                                 20 

 
           
             523  
             20  
             DNA  
             Homo sapiens  
           
            523 

atatagtttc gtcattcatc                                                 20 

 
           
             524  
             20  
             DNA  
             Homo sapiens  
           
            524 

tacattgccc atgtaattaa                                                 20 

 
           
             525  
             20  
             DNA  
             Homo sapiens  
           
            525 

agatagtttc gtcattcatc                                                 20 

 
           
             526  
             20  
             DNA  
             Homo sapiens  
           
            526 

agatagtttc ctcattcatc                                                 20 

 
           
             527  
             20  
             DNA  
             Homo sapiens  
           
            527 

agatagtttc gccattcatc                                                 20 

 
           
             528  
             20  
             DNA  
             Homo sapiens  
           
            528 

agatagtttc gtcattcatc                                                 20 

 
           
             529  
             21  
             DNA  
             Homo sapiens  
           
            529 

cacccctcat catacctcaa a                                               21 

 
           
             530  
             21  
             DNA  
             Homo sapiens  
           
            530 

acccctcatc ctacctcaaa a                                               21 

 
           
             531  
             21  
             DNA  
             Homo sapiens  
           
            531 

cccctcatca cacctcaaaa a                                               21 

 
           
             532  
             21  
             DNA  
             Homo sapiens  
           
            532 

ccctcatcat ccctcaaaaa c                                               21 

 
           
             533  
             21  
             DNA  
             Homo sapiens  
           
            533 

cctcatcata cctcaaaaac c                                               21 

 
           
             534  
             21  
             DNA  
             Homo sapiens  
           
            534 

ctcatcatac ctcaaaaacc a                                               21 

 
           
             535  
             21  
             DNA  
             Homo sapiens  
           
            535 

tcatcatacc ccaaaaacca a                                               21 

 
           
             536  
             21  
             DNA  
             Homo sapiens  
           
            536 

catcatacct caaaaaccaa c                                               21 

 
           
             537  
             21  
             DNA  
             Homo sapiens  
           
            537 

atcatacctc caaaaccaac t                                               21 

 
           
             538  
             21  
             DNA  
             Homo sapiens  
           
            538 

tcatacctca caaaccaact a                                               21 

 
           
             539  
             21  
             DNA  
             Homo sapiens  
           
            539 

catacctcaa caaccaacta a                                               21 

 
           
             540  
             21  
             DNA  
             Homo sapiens  
           
            540 

atacctcaaa caccaactaa c                                               21 

 
           
             541  
             21  
             DNA  
             Homo sapiens  
           
            541 

atcatacctc aaccaccacc c                                               21 

 
           
             542  
             21  
             DNA  
             Homo sapiens  
           
            542 

tcatacctca accaccaccc c                                               21 

 
           
             543  
             21  
             DNA  
             Homo sapiens  
           
            543 

catacctcaa acaccacccc t                                               21 

 
           
             544  
             21  
             DNA  
             Homo sapiens  
           
            544 

atacctcaac aaccacccct c                                               21 

 
           
             545  
             21  
             DNA  
             Homo sapiens  
           
            545 

tacctcaacc accacccctc a                                               21 

 
           
             546  
             21  
             DNA  
             Homo sapiens  
           
            546 

acctcaacca acacccctca t                                               21 

 
           
             547  
             21  
             DNA  
             Homo sapiens  
           
            547 

cctcaaccac aacccctcat c                                               21 

 
           
             548  
             21  
             DNA  
             Homo sapiens  
           
            548 

ctcaaccacc acccctcatc a                                               21 

 
           
             549  
             21  
             DNA  
             Homo sapiens  
           
            549 

tcaaccacca accctcatca t                                               21 

 
           
             550  
             21  
             DNA  
             Homo sapiens  
           
            550 

caaccaccac acctcatcat a                                               21 

 
           
             551  
             21  
             DNA  
             Homo sapiens  
           
            551 

aaccaccacc actcatcata c                                               21 

 
           
             552  
             21  
             DNA  
             Homo sapiens  
           
            552 

accaccaccc atcatcatac c                                               21 

 
           
             553  
             21  
             DNA  
             Homo sapiens  
           
            553 

ccaccacccc acatcatacc t                                               21 

 
           
             554  
             21  
             DNA  
             Homo sapiens  
           
            554 

caccacccct aatcatacct c                                               21 

 
           
             555  
             21  
             DNA  
             Homo sapiens  
           
            555 

accacccctc atcatacctc a                                               21 

 
           
             556  
             21  
             DNA  
             Homo sapiens  
           
            556 

ccacccctca acatacctca a                                               21 

 
           
             557  
             20  
             DNA  
             Homo sapiens  
           
            557 

tacattgccc atgtaattaa                                                 20 

 
           
             558  
             20  
             DNA  
             Homo sapiens  
           
            558 

atatagtttc gtcattcatc                                                 20 

 
           
             559  
             20  
             DNA  
             Homo sapiens  
           
            559 

tacattgccc atgtaattaa                                                 20 

 
           
             560  
             20  
             DNA  
             Homo sapiens  
           
            560 

atatagtttc gtcattcatc                                                 20 

 
           
             561  
             20  
             DNA  
             Homo sapiens  
           
            561 

agatagttta gtcattcatc                                                 20 

 
           
             562  
             20  
             DNA  
             Homo sapiens  
           
            562 

agatagtttc atcattcatc                                                 20 

 
           
             563  
             20  
             DNA  
             Homo sapiens  
           
            563 

agatagtttc gacattcatc                                                 20 

 
           
             564  
             20  
             DNA  
             Homo sapiens  
           
            564 

agatagtttc gtaattcatc                                                 20 

 
           
             565  
             21  
             DNA  
             Homo sapiens  
           
            565 

cacccctcat aatacctcaa a                                               21 

 
           
             566  
             21  
             DNA  
             Homo sapiens  
           
            566 

acccctcatc atacctcaaa a                                               21 

 
           
             567  
             21  
             DNA  
             Homo sapiens  
           
            567 

cccctcatca aacctcaaaa a                                               21 

 
           
             568  
             21  
             DNA  
             Homo sapiens  
           
            568 

ccctcatcat acctcaaaaa c                                               21 

 
           
             569  
             21  
             DNA  
             Homo sapiens  
           
            569 

cctcatcata actcaaaaac c                                               21 

 
           
             570  
             21  
             DNA  
             Homo sapiens  
           
            570 

ctcatcatac atcaaaaacc a                                               21 

 
           
             571  
             21  
             DNA  
             Homo sapiens  
           
            571 

tcatcatacc acaaaaacca a                                               21 

 
           
             572  
             21  
             DNA  
             Homo sapiens  
           
            572 

catcatacct aaaaaaccaa c                                               21 

 
           
             573  
             21  
             DNA  
             Homo sapiens  
           
            573 

atcatacctc aaaaaccaac t                                               21 

 
           
             574  
             21  
             DNA  
             Homo sapiens  
           
            574 

tcatacctca aaaaccaact a                                               21 

 
           
             575  
             21  
             DNA  
             Homo sapiens  
           
            575 

catacctcaa aaaccaacta a                                               21 

 
           
             576  
             21  
             DNA  
             Homo sapiens  
           
            576 

atacctcaaa aaccaactaa c                                               21 

 
           
             577  
             21  
             DNA  
             Homo sapiens  
           
            577 

tacctcaaaa tccaactaac c                                               21 

 
           
             578  
             21  
             DNA  
             Homo sapiens  
           
            578 

acctcaaaaa tcaactaacc a                                               21 

 
           
             579  
             21  
             DNA  
             Homo sapiens  
           
            579 

cctcaaaaac taactaacca a                                               21 

 
           
             580  
             21  
             DNA  
             Homo sapiens  
           
            580 

ctcaaaaacc tactaaccaa c                                               21 

 
           
             581  
             21  
             DNA  
             Homo sapiens  
           
            581 

tcaaaaacca tctaaccaac c                                               21 

 
           
             582  
             21  
             DNA  
             Homo sapiens  
           
            582 

caaaaaccaa ttaaccaacc a                                               21 

 
           
             583  
             21  
             DNA  
             Homo sapiens  
           
            583 

aaaaaccaac taaccaacca a                                               21 

 
           
             584  
             21  
             DNA  
             Homo sapiens  
           
            584 

aaaaccaact taccaaccaa t                                               21 

 
           
             585  
             21  
             DNA  
             Homo sapiens  
           
            585 

aaccaaccaa taatctccca c                                               21 

 
           
             586  
             21  
             DNA  
             Homo sapiens  
           
            586 

accaaccaat tatctcccac c                                               21 

 
           
             587  
             21  
             DNA  
             Homo sapiens  
           
            587 

ccaaccaata ttctcccacc c                                               21 

 
           
             588  
             21  
             DNA  
             Homo sapiens  
           
            588 

caaccaataa tctcccaccc c                                               21 

 
           
             589  
             21  
             DNA  
             Homo sapiens  
           
            589 

aaccaataat ttcccacccc g                                               21 

 
           
             590  
             20  
             DNA  
             Homo sapiens  
           
            590 

atatagtttc gtcattcatc                                                 20 

 
           
             591  
             20  
             DNA  
             Homo sapiens  
           
            591 

tacattgccc atgtaattaa                                                 20 

 
           
             592  
             20  
             DNA  
             Homo sapiens  
           
            592 

atatagtttc gtcattcatc                                                 20 

 
           
             593  
             20  
             DNA  
             Homo sapiens  
           
            593 

tacattgccc atgtaattaa                                                 20 

 
           
             594  
             20  
             DNA  
             Homo sapiens  
           
            594 

agatagtttt gtcattcatc                                                 20 

 
           
             595  
             20  
             DNA  
             Homo sapiens  
           
            595 

agatagtttc ttcattcatc                                                 20 

 
           
             596  
             20  
             DNA  
             Homo sapiens  
           
            596 

agatagtttc gtcattcatc                                                 20 

 
           
             597  
             20  
             DNA  
             Homo sapiens  
           
            597 

agatagtttc gttattcatc                                                 20 

 
           
             598  
             21  
             DNA  
             Homo sapiens  
           
            598 

accaataatc tcccaccccg c                                               21 

 
           
             599  
             21  
             DNA  
             Homo sapiens  
           
            599 

ccaataatct tccaccccgc c                                               21 

 
           
             600  
             21  
             DNA  
             Homo sapiens  
           
            600 

caataatctc tcaccccgcc t                                               21 

 
           
             601  
             21  
             DNA  
             Homo sapiens  
           
            601 

aataatctcc taccccgcct a                                               21 

 
           
             602  
             21  
             DNA  
             Homo sapiens  
           
            602 

ataatctccc tccccgccta g                                               21 

 
           
             603  
             21  
             DNA  
             Homo sapiens  
           
            603 

taatctccca tcccgcctag c                                               21 

 
           
             604  
             21  
             DNA  
             Homo sapiens  
           
            604 

aatctcccac tccgcctagc t                                               21 

 
           
             605  
             21  
             DNA  
             Homo sapiens  
           
            605 

atctcccacc tcgcctagct c                                               21 

 
           
             606  
             21  
             DNA  
             Homo sapiens  
           
            606 

tctcccaccc tgcctagctc a                                               21 

 
           
             607  
             21  
             DNA  
             Homo sapiens  
           
            607 

ctcccacccc tcctagctca c                                               21 

 
           
             608  
             21  
             DNA  
             Homo sapiens  
           
            608 

tcccaccccg tctagctcac g                                               21 

 
           
             609  
             21  
             DNA  
             Homo sapiens  
           
            609 

cccaccccgc ttagctcacg c                                               21 

 
           
             610  
             21  
             DNA  
             Homo sapiens  
           
            610 

ccaccccgcc tagctcacgc a                                               21 

 
           
             611  
             21  
             DNA  
             Homo sapiens  
           
            611 

caccccgcct tgctcacgca a                                               21 

 
           
             612  
             21  
             DNA  
             Homo sapiens  
           
            612 

accccgccta tctcacgcaa g                                               21 

 
           
             613  
             21  
             DNA  
             Homo sapiens  
           
            613 

tacctcaaaa gccaactaac c                                               21 

 
           
             614  
             21  
             DNA  
             Homo sapiens  
           
            614 

acctcaaaaa gcaactaacc a                                               21 

 
           
             615  
             21  
             DNA  
             Homo sapiens  
           
            615 

cctcaaaaac gaactaacca a                                               21 

 
           
             616  
             21  
             DNA  
             Homo sapiens  
           
            616 

ctcaaaaacc gactaaccaa c                                               21 

 
           
             617  
             21  
             DNA  
             Homo sapiens  
           
            617 

tcaaaaacca gctaaccaac c                                               21 

 
           
             618  
             21  
             DNA  
             Homo sapiens  
           
            618 

caaaaaccaa gtaaccaacc a                                               21 

 
           
             619  
             21  
             DNA  
             Homo sapiens  
           
            619 

aaaaaccaac gaaccaacca a                                               21 

 
           
             620  
             21  
             DNA  
             Homo sapiens  
           
            620 

aaaaccaact gaccaaccaa t                                               21 

 
           
             621  
             21  
             DNA  
             Homo sapiens  
           
            621 

aaccaaccaa gaatctccca c                                               21 

 
           
             622  
             21  
             DNA  
             Homo sapiens  
           
            622 

accaaccaat gatctcccac c                                               21 

 
           
             623  
             21  
             DNA  
             Homo sapiens  
           
            623 

ccaaccaata gtctcccacc c                                               21 

 
           
             624  
             21  
             DNA  
             Homo sapiens  
           
            624 

caaccaataa gctcccaccc c                                               21 

 
           
             625  
             21  
             DNA  
             Homo sapiens  
           
            625 

aaccaataat gtcccacccc g                                               21 

 
           
             626  
             20  
             DNA  
             Homo sapiens  
           
            626 

tacattgccc atgtaattaa                                                 20 

 
           
             627  
             20  
             DNA  
             Homo sapiens  
           
            627 

atatagtttc gtcattcatc                                                 20 

 
           
             628  
             20  
             DNA  
             Homo sapiens  
           
            628 

tacattgccc atgtaattaa                                                 20 

 
           
             629  
             20  
             DNA  
             Homo sapiens  
           
            629 

atatagtttc gtcattcatc                                                 20 

 
           
             630  
             20  
             DNA  
             Homo sapiens  
           
            630 

agatagtttg gtcattcatc                                                 20 

 
           
             631  
             20  
             DNA  
             Homo sapiens  
           
            631 

agatagtttc gtcattcatc                                                 20 

 
           
             632  
             20  
             DNA  
             Homo sapiens  
           
            632 

agatagtttc ggcattcatc                                                 20 

 
           
             633  
             20  
             DNA  
             Homo sapiens  
           
            633 

agatagtttc gtgattcatc                                                 20 

 
           
             634  
             21  
             DNA  
             Homo sapiens  
           
            634 

accaataatc gcccaccccg c                                               21 

 
           
             635  
             21  
             DNA  
             Homo sapiens  
           
            635 

ccaataatct gccaccccgc c                                               21 

 
           
             636  
             21  
             DNA  
             Homo sapiens  
           
            636 

caataatctc gcaccccgcc t                                               21 

 
           
             637  
             21  
             DNA  
             Homo sapiens  
           
            637 

aataatctcc gaccccgcct a                                               21 

 
           
             638  
             21  
             DNA  
             Homo sapiens  
           
            638 

ataatctccc gccccgccta g                                               21 

 
           
             639  
             21  
             DNA  
             Homo sapiens  
           
            639 

taatctccca gcccgcctag c                                               21 

 
           
             640  
             21  
             DNA  
             Homo sapiens  
           
            640 

aatctcccac gccgcctagc t                                               21 

 
           
             641  
             21  
             DNA  
             Homo sapiens  
           
            641 

atctcccacc gcgcctagct c                                               21 

 
           
             642  
             21  
             DNA  
             Homo sapiens  
           
            642 

tctcccaccc ggcctagctc a                                               21 

 
           
             643  
             21  
             DNA  
             Homo sapiens  
           
            643 

ctcccacccc gcctagctca c                                               21 

 
           
             644  
             21  
             DNA  
             Homo sapiens  
           
            644 

tcccaccccg gctagctcac g                                               21 

 
           
             645  
             21  
             DNA  
             Homo sapiens  
           
            645 

cccaccccgc gtagctcacg c                                               21 

 
           
             646  
             21  
             DNA  
             Homo sapiens  
           
            646 

ccaccccgcc gagctcacgc a                                               21 

 
           
             647  
             21  
             DNA  
             Homo sapiens  
           
            647 

caccccgcct ggctcacgca a                                               21 

 
           
             648  
             21  
             DNA  
             Homo sapiens  
           
            648 

accccgccta gctcacgcaa g                                               21 

 
           
             649  
             21  
             DNA  
             Homo sapiens  
           
            649 

tacctcaaaa cccaactaac c                                               21 

 
           
             650  
             21  
             DNA  
             Homo sapiens  
           
            650 

acctcaaaaa ccaactaacc a                                               21 

 
           
             651  
             21  
             DNA  
             Homo sapiens  
           
            651 

cctcaaaaac caactaacca a                                               21 

 
           
             652  
             21  
             DNA  
             Homo sapiens  
           
            652 

ctcaaaaacc cactaaccaa c                                               21 

 
           
             653  
             21  
             DNA  
             Homo sapiens  
           
            653 

tcaaaaacca cctaaccaac c                                               21 

 
           
             654  
             21  
             DNA  
             Homo sapiens  
           
            654 

caaaaaccaa ctaaccaacc a                                               21 

 
           
             655  
             21  
             DNA  
             Homo sapiens  
           
            655 

aaaaaccaac caaccaacca a                                               21 

 
           
             656  
             21  
             DNA  
             Homo sapiens  
           
            656 

aaaaccaact caccaaccaa t                                               21 

 
           
             657  
             21  
             DNA  
             Homo sapiens  
           
            657 

aaccaaccaa caatctccca c                                               21 

 
           
             658  
             21  
             DNA  
             Homo sapiens  
           
            658 

accaaccaat catctcccac c                                               21 

 
           
             659  
             21  
             DNA  
             Homo sapiens  
           
            659 

ccaaccaata ctctcccacc c                                               21 

 
           
             660  
             21  
             DNA  
             Homo sapiens  
           
            660 

caaccaataa cctcccaccc c                                               21 

 
           
             661  
             21  
             DNA  
             Homo sapiens  
           
            661 

aaccaataat ctcccacccc g                                               21 

 
           
             662  
             20  
             DNA  
             Homo sapiens  
           
            662 

atatagtttc gtcattcatc                                                 20 

 
           
             663  
             20  
             DNA  
             Homo sapiens  
           
            663 

tacattgccc atgtaattaa                                                 20 

 
           
             664  
             20  
             DNA  
             Homo sapiens  
           
            664 

atatagtttc gtcattcatc                                                 20 

 
           
             665  
             20  
             DNA  
             Homo sapiens  
           
            665 

tacattgccc atgtaattaa                                                 20 

 
           
             666  
             20  
             DNA  
             Homo sapiens  
           
            666 

agatagtttc gtcattcatc                                                 20 

 
           
             667  
             20  
             DNA  
             Homo sapiens  
           
            667 

agatagtttc ctcattcatc                                                 20 

 
           
             668  
             20  
             DNA  
             Homo sapiens  
           
            668 

agatagtttc gccattcatc                                                 20 

 
           
             669  
             20  
             DNA  
             Homo sapiens  
           
            669 

agatagtttc gtcattcatc                                                 20 

 
           
             670  
             21  
             DNA  
             Homo sapiens  
           
            670 

accaataatc ccccaccccg c                                               21 

 
           
             671  
             21  
             DNA  
             Homo sapiens  
           
            671 

ccaataatct cccaccccgc c                                               21 

 
           
             672  
             21  
             DNA  
             Homo sapiens  
           
            672 

caataatctc ccaccccgcc t                                               21 

 
           
             673  
             21  
             DNA  
             Homo sapiens  
           
            673 

aataatctcc caccccgcct a                                               21 

 
           
             674  
             21  
             DNA  
             Homo sapiens  
           
            674 

ataatctccc cccccgccta g                                               21 

 
           
             675  
             21  
             DNA  
             Homo sapiens  
           
            675 

taatctccca ccccgcctag c                                               21 

 
           
             676  
             21  
             DNA  
             Homo sapiens  
           
            676 

aatctcccac cccgcctagc t                                               21 

 
           
             677  
             21  
             DNA  
             Homo sapiens  
           
            677 

atctcccacc ccgcctagct c                                               21 

 
           
             678  
             21  
             DNA  
             Homo sapiens  
           
            678 

tctcccaccc cgcctagctc a                                               21 

 
           
             679  
             21  
             DNA  
             Homo sapiens  
           
            679 

ctcccacccc ccctagctca c                                               21 

 
           
             680  
             21  
             DNA  
             Homo sapiens  
           
            680 

tcccaccccg cctagctcac g                                               21 

 
           
             681  
             21  
             DNA  
             Homo sapiens  
           
            681 

cccaccccgc ctagctcacg c                                               21 

 
           
             682  
             21  
             DNA  
             Homo sapiens  
           
            682 

ccaccccgcc cagctcacgc a                                               21 

 
           
             683  
             21  
             DNA  
             Homo sapiens  
           
            683 

caccccgcct cgctcacgca a                                               21 

 
           
             684  
             21  
             DNA  
             Homo sapiens  
           
            684 

accccgccta cctcacgcaa g                                               21 

 
           
             685  
             21  
             DNA  
             Homo sapiens  
           
            685 

tacctcaaaa accaactaac c                                               21 

 
           
             686  
             21  
             DNA  
             Homo sapiens  
           
            686 

acctcaaaaa acaactaacc a                                               21 

 
           
             687  
             21  
             DNA  
             Homo sapiens  
           
            687 

cctcaaaaac aaactaacca a                                               21 

 
           
             688  
             21  
             DNA  
             Homo sapiens  
           
            688 

ctcaaaaacc aactaaccaa c                                               21 

 
           
             689  
             21  
             DNA  
             Homo sapiens  
           
            689 

tcaaaaacca actaaccaac c                                               21 

 
           
             690  
             21  
             DNA  
             Homo sapiens  
           
            690 

caaaaaccaa ataaccaacc a                                               21 

 
           
             691  
             21  
             DNA  
             Homo sapiens  
           
            691 

aaaaaccaac aaaccaacca a                                               21 

 
           
             692  
             21  
             DNA  
             Homo sapiens  
           
            692 

aaaaccaact aaccaaccaa t                                               21 

 
           
             693  
             21  
             DNA  
             Homo sapiens  
           
            693 

aaccaaccaa aaatctccca c                                               21 

 
           
             694  
             21  
             DNA  
             Homo sapiens  
           
            694 

accaaccaat aatctcccac c                                               21 

 
           
             695  
             21  
             DNA  
             Homo sapiens  
           
            695 

ccaaccaata atctcccacc c                                               21 

 
           
             696  
             21  
             DNA  
             Homo sapiens  
           
            696 

caaccaataa actcccaccc c                                               21 

 
           
             697  
             21  
             DNA  
             Homo sapiens  
           
            697 

aaccaataat atcccacccc g                                               21 

 
           
             698  
             20  
             DNA  
             Homo sapiens  
           
            698 

tacattgccc atgtaattaa                                                 20 

 
           
             699  
             20  
             DNA  
             Homo sapiens  
           
            699 

atatagtttc gtcattcatc                                                 20 

 
           
             700  
             20  
             DNA  
             Homo sapiens  
           
            700 

tacattgccc atgtaattaa                                                 20 

 
           
             701  
             20  
             DNA  
             Homo sapiens  
           
            701 

atatagtttc gtcattcatc                                                 20 

 
           
             702  
             20  
             DNA  
             Homo sapiens  
           
            702 

agatagttta gtcattcatc                                                 20 

 
           
             703  
             20  
             DNA  
             Homo sapiens  
           
            703 

agatagtttc atcattcatc                                                 20 

 
           
             704  
             20  
             DNA  
             Homo sapiens  
           
            704 

agatagtttc gacattcatc                                                 20 

 
           
             705  
             20  
             DNA  
             Homo sapiens  
           
            705 

agatagtttc gtaattcatc                                                 20 

 
           
             706  
             21  
             DNA  
             Homo sapiens  
           
            706 

accaataatc acccaccccg c                                               21 

 
           
             707  
             21  
             DNA  
             Homo sapiens  
           
            707 

ccaataatct accaccccgc c                                               21 

 
           
             708  
             21  
             DNA  
             Homo sapiens  
           
            708 

caataatctc acaccccgcc t                                               21 

 
           
             709  
             21  
             DNA  
             Homo sapiens  
           
            709 

aataatctcc aaccccgcct a                                               21 

 
           
             710  
             21  
             DNA  
             Homo sapiens  
           
            710 

ataatctccc accccgccta g                                               21 

 
           
             711  
             21  
             DNA  
             Homo sapiens  
           
            711 

taatctccca acccgcctag c                                               21 

 
           
             712  
             21  
             DNA  
             Homo sapiens  
           
            712 

aatctcccac accgcctagc t                                               21 

 
           
             713  
             21  
             DNA  
             Homo sapiens  
           
            713 

atctcccacc acgcctagct c                                               21 

 
           
             714  
             21  
             DNA  
             Homo sapiens  
           
            714 

tctcccaccc agcctagctc a                                               21 

 
           
             715  
             21  
             DNA  
             Homo sapiens  
           
            715 

ctcccacccc acctagctca c                                               21 

 
           
             716  
             21  
             DNA  
             Homo sapiens  
           
            716 

tcccaccccg actagctcac g                                               21 

 
           
             717  
             21  
             DNA  
             Homo sapiens  
           
            717 

cccaccccgc atagctcacg c                                               21 

 
           
             718  
             21  
             DNA  
             Homo sapiens  
           
            718 

ccaccccgcc aagctcacgc a                                               21 

 
           
             719  
             21  
             DNA  
             Homo sapiens  
           
            719 

caccccgcct agctcacgca a                                               21 

 
           
             720  
             21  
             DNA  
             Homo sapiens  
           
            720 

accccgccta actcacgcaa g                                               21 

 
           
             721  
             21  
             DNA  
             Homo sapiens  
           
            721 

ccccgcctag ttcacgcaag c                                               21 

 
           
             722  
             21  
             DNA  
             Homo sapiens  
           
            722 

cccgcctagc tcacgcaagc c                                               21 

 
           
             723  
             21  
             DNA  
             Homo sapiens  
           
            723 

ccgcctagct tacgcaagcc g                                               21 

 
           
             724  
             21  
             DNA  
             Homo sapiens  
           
            724 

cgcctagctc tcgcaagccg c                                               21 

 
           
             725  
             21  
             DNA  
             Homo sapiens  
           
            725 

gcctagctca tgcaagccgc c                                               21 

 
           
             726  
             21  
             DNA  
             Homo sapiens  
           
            726 

cctagctcac tcaagccgcc a                                               21 

 
           
             727  
             21  
             DNA  
             Homo sapiens  
           
            727 

ctagctcacg taagccgcca a                                               21 

 
           
             728  
             21  
             DNA  
             Homo sapiens  
           
            728 

tagctcacgc tagccgccaa c                                               21 

 
           
             729  
             21  
             DNA  
             Homo sapiens  
           
            729 

agctcacgca tgccgccaac g                                               21 

 
           
             730  
             21  
             DNA  
             Homo sapiens  
           
            730 

gctcacgcaa tccgccaacg c                                               21 

 
           
             731  
             20  
             DNA  
             Homo sapiens  
           
            731 

atatagtttc gtcattcatc                                                 20 

 
           
             732  
             20  
             DNA  
             Homo sapiens  
           
            732 

tacattgccc atgtaattaa                                                 20 

 
           
             733  
             20  
             DNA  
             Homo sapiens  
           
            733 

atatagtttc gtcattcatc                                                 20 

 
           
             734  
             20  
             DNA  
             Homo sapiens  
           
            734 

tacattgccc atgtaattaa                                                 20 

 
           
             735  
             20  
             DNA  
             Homo sapiens  
           
            735 

agatagtttt gtcattcatc                                                 20 

 
           
             736  
             20  
             DNA  
             Homo sapiens  
           
            736 

agatagtttc ttcattcatc                                                 20 

 
           
             737  
             20  
             DNA  
             Homo sapiens  
           
            737 

agatagtttc gtcattcatc                                                 20 

 
           
             738  
             20  
             DNA  
             Homo sapiens  
           
            738 

agatagtttc gttattcatc                                                 20 

 
           
             739  
             21  
             DNA  
             Homo sapiens  
           
            739 

ctcacgcaag tcgccaacgc c                                               21 

 
           
             740  
             21  
             DNA  
             Homo sapiens  
           
            740 

tcacgcaagc tgccaacgcc t                                               21 

 
           
             741  
             21  
             DNA  
             Homo sapiens  
           
            741 

cacgcaagcc tccaacgcct c                                               21 

 
           
             742  
             21  
             DNA  
             Homo sapiens  
           
            742 

acgcaagccg tcaacgcctc t                                               21 

 
           
             743  
             21  
             DNA  
             Homo sapiens  
           
            743 

cgcaagccgc taacgcctct c                                               21 

 
           
             744  
             21  
             DNA  
             Homo sapiens  
           
            744 

gcaagccgcc tacgcctctc c                                               21 

 
           
             745  
             21  
             DNA  
             Homo sapiens  
           
            745 

caagccgcca tcgcctctcc c                                               21 

 
           
             746  
             21  
             DNA  
             Homo sapiens  
           
            746 

aagccgccaa tgcctctccc c                                               21 

 
           
             747  
             21  
             DNA  
             Homo sapiens  
           
            747 

agccgccaac tcctctcccc c                                               21 

 
           
             748  
             21  
             DNA  
             Homo sapiens  
           
            748 

gccgccaacg tctctccccc t                                               21 

 
           
             749  
             21  
             DNA  
             Homo sapiens  
           
            749 

ccgccaacgc ttctccccct c                                               21 

 
           
             750  
             21  
             DNA  
             Homo sapiens  
           
            750 

cgccaacgcc tctccccctc t                                               21 

 
           
             751  
             21  
             DNA  
             Homo sapiens  
           
            751 

gccaacgcct ttccccctct c                                               21 

 
           
             752  
             21  
             DNA  
             Homo sapiens  
           
            752 

ccaacgcctc tccccctctc a                                               21 

 
           
             753  
             21  
             DNA  
             Homo sapiens  
           
            753 

caacgcctct tcccctctca t                                               21 

 
           
             754  
             21  
             DNA  
             Homo sapiens  
           
            754 

aacgcctctc tccctctcat c                                               21 

 
           
             755  
             21  
             DNA  
             Homo sapiens  
           
            755 

acgcctctcc tcctctcatc c                                               21 

 
           
             756  
             21  
             DNA  
             Homo sapiens  
           
            756 

cgcctctccc tctctcatcc a                                               21 

 
           
             757  
             21  
             DNA  
             Homo sapiens  
           
            757 

ccccgcctag gtcacgcaag c                                               21 

 
           
             758  
             21  
             DNA  
             Homo sapiens  
           
            758 

cccgcctagc gcacgcaagc c                                               21 

 
           
             759  
             21  
             DNA  
             Homo sapiens  
           
            759 

ccgcctagct gacgcaagcc g                                               21 

 
           
             760  
             21  
             DNA  
             Homo sapiens  
           
            760 

cgcctagctc gcgcaagccg c                                               21 

 
           
             761  
             21  
             DNA  
             Homo sapiens  
           
            761 

gcctagctca ggcaagccgc c                                               21 

 
           
             762  
             21  
             DNA  
             Homo sapiens  
           
            762 

cctagctcac gcaagccgcc a                                               21 

 
           
             763  
             21  
             DNA  
             Homo sapiens  
           
            763 

ctagctcacg gaagccgcca a                                               21 

 
           
             764  
             21  
             DNA  
             Homo sapiens  
           
            764 

tagctcacgc gagccgccaa c                                               21 

 
           
             765  
             21  
             DNA  
             Homo sapiens  
           
            765 

agctcacgca ggccgccaac g                                               21 

 
           
             766  
             21  
             DNA  
             Homo sapiens  
           
            766 

gctcacgcaa gccgccaacg c                                               21 

 
           
             767  
             20  
             DNA  
             Homo sapiens  
           
            767 

tacattgccc atgtaattaa                                                 20 

 
           
             768  
             20  
             DNA  
             Homo sapiens  
           
            768 

atatagtttc gtcattcatc                                                 20 

 
           
             769  
             20  
             DNA  
             Homo sapiens  
           
            769 

tacattgccc atgtaattaa                                                 20 

 
           
             770  
             20  
             DNA  
             Homo sapiens  
           
            770 

atatagtttc gtcattcatc                                                 20 

 
           
             771  
             20  
             DNA  
             Homo sapiens  
           
            771 

agatagtttg gtcattcatc                                                 20 

 
           
             772  
             20  
             DNA  
             Homo sapiens  
           
            772 

agatagtttc gtcattcatc                                                 20 

 
           
             773  
             20  
             DNA  
             Homo sapiens  
           
            773 

agatagtttc ggcattcatc                                                 20 

 
           
             774  
             20  
             DNA  
             Homo sapiens  
           
            774 

agatagtttc gtgattcatc                                                 20 

 
           
             775  
             21  
             DNA  
             Homo sapiens  
           
            775 

ctcacgcaag gcgccaacgc c                                               21 

 
           
             776  
             21  
             DNA  
             Homo sapiens  
           
            776 

tcacgcaagc ggccaacgcc t                                               21 

 
           
             777  
             21  
             DNA  
             Homo sapiens  
           
            777 

cacgcaagcc gccaacgcct c                                               21 

 
           
             778  
             21  
             DNA  
             Homo sapiens  
           
            778 

acgcaagccg gcaacgcctc t                                               21 

 
           
             779  
             21  
             DNA  
             Homo sapiens  
           
            779 

cgcaagccgc gaacgcctct c                                               21 

 
           
             780  
             21  
             DNA  
             Homo sapiens  
           
            780 

gcaagccgcc gacgcctctc c                                               21 

 
           
             781  
             21  
             DNA  
             Homo sapiens  
           
            781 

caagccgcca gcgcctctcc c                                               21 

 
           
             782  
             21  
             DNA  
             Homo sapiens  
           
            782 

aagccgccaa ggcctctccc c                                               21 

 
           
             783  
             21  
             DNA  
             Homo sapiens  
           
            783 

agccgccaac gcctctcccc c                                               21 

 
           
             784  
             21  
             DNA  
             Homo sapiens  
           
            784 

gccgccaacg gctctccccc t                                               21 

 
           
             785  
             21  
             DNA  
             Homo sapiens  
           
            785 

ccgccaacgc gtctccccct c                                               21 

 
           
             786  
             21  
             DNA  
             Homo sapiens  
           
            786 

cgccaacgcc gctccccctc t                                               21 

 
           
             787  
             21  
             DNA  
             Homo sapiens  
           
            787 

gccaacgcct gtccccctct c                                               21 

 
           
             788  
             21  
             DNA  
             Homo sapiens  
           
            788 

ccaacgcctc gccccctctc a                                               21 

 
           
             789  
             21  
             DNA  
             Homo sapiens  
           
            789 

caacgcctct gcccctctca t                                               21 

 
           
             790  
             21  
             DNA  
             Homo sapiens  
           
            790 

aacgcctctc gccctctcat c                                               21 

 
           
             791  
             21  
             DNA  
             Homo sapiens  
           
            791 

acgcctctcc gcctctcatc c                                               21 

 
           
             792  
             21  
             DNA  
             Homo sapiens  
           
            792 

cgcctctccc gctctcatcc a                                               21 

 
           
             793  
             21  
             DNA  
             Homo sapiens  
           
            793 

ccccgcctag ctcacgcaag c                                               21 

 
           
             794  
             21  
             DNA  
             Homo sapiens  
           
            794 

cccgcctagc ccacgcaagc c                                               21 

 
           
             795  
             21  
             DNA  
             Homo sapiens  
           
            795 

ccgcctagct cacgcaagcc g                                               21 

 
           
             796  
             21  
             DNA  
             Homo sapiens  
           
            796 

cgcctagctc ccgcaagccg c                                               21 

 
           
             797  
             21  
             DNA  
             Homo sapiens  
           
            797 

gcctagctca cgcaagccgc c                                               21 

 
           
             798  
             21  
             DNA  
             Homo sapiens  
           
            798 

cctagctcac ccaagccgcc a                                               21 

 
           
             799  
             21  
             DNA  
             Homo sapiens  
           
            799 

ctagctcacg caagccgcca a                                               21 

 
           
             800  
             21  
             DNA  
             Homo sapiens  
           
            800 

tagctcacgc cagccgccaa c                                               21 

 
           
             801  
             21  
             DNA  
             Homo sapiens  
           
            801 

agctcacgca cgccgccaac g                                               21 

 
           
             802  
             21  
             DNA  
             Homo sapiens  
           
            802 

gctcacgcaa cccgccaacg c                                               21 

 
           
             803  
             20  
             DNA  
             Homo sapiens  
           
            803 

atatagtttc gtcattcatc                                                 20 

 
           
             804  
             20  
             DNA  
             Homo sapiens  
           
            804 

tacattgccc atgtaattaa                                                 20 

 
           
             805  
             20  
             DNA  
             Homo sapiens  
           
            805 

atatagtttc gtcattcatc                                                 20 

 
           
             806  
             20  
             DNA  
             Homo sapiens  
           
            806 

tacattgccc atgtaattaa                                                 20 

 
           
             807  
             20  
             DNA  
             Homo sapiens  
           
            807 

agatagtttc gtcattcatc                                                 20 

 
           
             808  
             20  
             DNA  
             Homo sapiens  
           
            808 

agatagtttc ctcattcatc                                                 20 

 
           
             809  
             20  
             DNA  
             Homo sapiens  
           
            809 

agatagtttc gccattcatc                                                 20 

 
           
             810  
             20  
             DNA  
             Homo sapiens  
           
            810 

agatagtttc gtcattcatc                                                 20 

 
           
             811  
             21  
             DNA  
             Homo sapiens  
           
            811 

ctcacgcaag ccgccaacgc c                                               21 

 
           
             812  
             21  
             DNA  
             Homo sapiens  
           
            812 

tcacgcaagc cgccaacgcc t                                               21 

 
           
             813  
             21  
             DNA  
             Homo sapiens  
           
            813 

cacgcaagcc cccaacgcct c                                               21 

 
           
             814  
             21  
             DNA  
             Homo sapiens  
           
            814 

acgcaagccg ccaacgcctc t                                               21 

 
           
             815  
             21  
             DNA  
             Homo sapiens  
           
            815 

cgcaagccgc caacgcctct c                                               21 

 
           
             816  
             21  
             DNA  
             Homo sapiens  
           
            816 

gcaagccgcc cacgcctctc c                                               21 

 
           
             817  
             21  
             DNA  
             Homo sapiens  
           
            817 

caagccgcca ccgcctctcc c                                               21 

 
           
             818  
             21  
             DNA  
             Homo sapiens  
           
            818 

aagccgccaa cgcctctccc c                                               21 

 
           
             819  
             21  
             DNA  
             Homo sapiens  
           
            819 

agccgccaac ccctctcccc c                                               21 

 
           
             820  
             21  
             DNA  
             Homo sapiens  
           
            820 

gccgccaacg cctctccccc t                                               21 

 
           
             821  
             21  
             DNA  
             Homo sapiens  
           
            821 

ccgccaacgc ctctccccct c                                               21 

 
           
             822  
             21  
             DNA  
             Homo sapiens  
           
            822 

cgccaacgcc cctccccctc t                                               21 

 
           
             823  
             21  
             DNA  
             Homo sapiens  
           
            823 

gccaacgcct ctccccctct c                                               21 

 
           
             824  
             21  
             DNA  
             Homo sapiens  
           
            824 

ccaacgcctc cccccctctc a                                               21 

 
           
             825  
             21  
             DNA  
             Homo sapiens  
           
            825 

caacgcctct ccccctctca t                                               21 

 
           
             826  
             21  
             DNA  
             Homo sapiens  
           
            826 

aacgcctctc cccctctcat c                                               21 

 
           
             827  
             21  
             DNA  
             Homo sapiens  
           
            827 

acgcctctcc ccctctcatc c                                               21 

 
           
             828  
             21  
             DNA  
             Homo sapiens  
           
            828 

cgcctctccc cctctcatcc a                                               21 

 
           
             829  
             21  
             DNA  
             Homo sapiens  
           
            829 

ccccgcctag atcacgcaag c                                               21 

 
           
             830  
             21  
             DNA  
             Homo sapiens  
           
            830 

cccgcctagc acacgcaagc c                                               21 

 
           
             831  
             21  
             DNA  
             Homo sapiens  
           
            831 

ccgcctagct aacgcaagcc g                                               21 

 
           
             832  
             21  
             DNA  
             Homo sapiens  
           
            832 

cgcctagctc acgcaagccg c                                               21 

 
           
             833  
             21  
             DNA  
             Homo sapiens  
           
            833 

gcctagctca agcaagccgc c                                               21 

 
           
             834  
             21  
             DNA  
             Homo sapiens  
           
            834 

cctagctcac acaagccgcc a                                               21 

 
           
             835  
             21  
             DNA  
             Homo sapiens  
           
            835 

ctagctcacg aaagccgcca a                                               21 

 
           
             836  
             21  
             DNA  
             Homo sapiens  
           
            836 

tagctcacgc aagccgccaa c                                               21 

 
           
             837  
             21  
             DNA  
             Homo sapiens  
           
            837 

agctcacgca agccgccaac g                                               21 

 
           
             838  
             21  
             DNA  
             Homo sapiens  
           
            838 

gctcacgcaa accgccaacg c                                               21 

 
           
             839  
             20  
             DNA  
             Homo sapiens  
           
            839 

tacattgccc atgtaattaa                                                 20 

 
           
             840  
             20  
             DNA  
             Homo sapiens  
           
            840 

atatagtttc gtcattcatc                                                 20 

 
           
             841  
             20  
             DNA  
             Homo sapiens  
           
            841 

tacattgccc atgtaattaa                                                 20 

 
           
             842  
             20  
             DNA  
             Homo sapiens  
           
            842 

atatagtttc gtcattcatc                                                 20 

 
           
             843  
             20  
             DNA  
             Homo sapiens  
           
            843 

agatagttta gtcattcatc                                                 20 

 
           
             844  
             20  
             DNA  
             Homo sapiens  
           
            844 

agatagtttc atcattcatc                                                 20 

 
           
             845  
             20  
             DNA  
             Homo sapiens  
           
            845 

agatagtttc gacattcatc                                                 20 

 
           
             846  
             20  
             DNA  
             Homo sapiens  
           
            846 

agatagtttc gtaattcatc                                                 20 

 
           
             847  
             21  
             DNA  
             Homo sapiens  
           
            847 

ctcacgcaag acgccaacgc c                                               21 

 
           
             848  
             21  
             DNA  
             Homo sapiens  
           
            848 

tcacgcaagc agccaacgcc t                                               21 

 
           
             849  
             21  
             DNA  
             Homo sapiens  
           
            849 

cacgcaagcc accaacgcct c                                               21 

 
           
             850  
             21  
             DNA  
             Homo sapiens  
           
            850 

acgcaagccg acaacgcctc t                                               21 

 
           
             851  
             21  
             DNA  
             Homo sapiens  
           
            851 

cgcaagccgc aaacgcctct c                                               21 

 
           
             852  
             21  
             DNA  
             Homo sapiens  
           
            852 

gcaagccgcc aacgcctctc c                                               21 

 
           
             853  
             21  
             DNA  
             Homo sapiens  
           
            853 

caagccgcca acgcctctcc c                                               21 

 
           
             854  
             21  
             DNA  
             Homo sapiens  
           
            854 

aagccgccaa agcctctccc c                                               21 

 
           
             855  
             21  
             DNA  
             Homo sapiens  
           
            855 

agccgccaac acctctcccc c                                               21 

 
           
             856  
             21  
             DNA  
             Homo sapiens  
           
            856 

gccgccaacg actctccccc t                                               21 

 
           
             857  
             21  
             DNA  
             Homo sapiens  
           
            857 

ccgccaacgc atctccccct c                                               21 

 
           
             858  
             21  
             DNA  
             Homo sapiens  
           
            858 

cgccaacgcc actccccctc t                                               21 

 
           
             859  
             21  
             DNA  
             Homo sapiens  
           
            859 

gccaacgcct atccccctct c                                               21 

 
           
             860  
             21  
             DNA  
             Homo sapiens  
           
            860 

ccaacgcctc accccctctc a                                               21 

 
           
             861  
             21  
             DNA  
             Homo sapiens  
           
            861 

caacgcctct acccctctca t                                               21 

 
           
             862  
             21  
             DNA  
             Homo sapiens  
           
            862 

aacgcctctc accctctcat c                                               21 

 
           
             863  
             21  
             DNA  
             Homo sapiens  
           
            863 

acgcctctcc acctctcatc c                                               21 

 
           
             864  
             21  
             DNA  
             Homo sapiens  
           
            864 

cgcctctccc actctcatcc a                                               21 

 
           
             865  
             21  
             DNA  
             Homo sapiens  
           
            865 

gcctctcccc ttctcatcca t                                               21 

 
           
             866  
             21  
             DNA  
             Homo sapiens  
           
            866 

cctctccccc tctcatccat c                                               21 

 
           
             867  
             21  
             DNA  
             Homo sapiens  
           
            867 

ctctccccct ttcatccatc g                                               21 

 
           
             868  
             21  
             DNA  
             Homo sapiens  
           
            868 

tctccccctc tcatccatcg c                                               21 

 
           
             869  
             21  
             DNA  
             Homo sapiens  
           
            869 

ctccccctct tatccatcgc c                                               21 

 
           
             870  
             21  
             DNA  
             Homo sapiens  
           
            870 

tccccctctc ttccatcgcc c                                               21 

 
           
             871  
             21  
             DNA  
             Homo sapiens  
           
            871 

ccccctctca tccatcgccc g                                               21 

 
           
             872  
             20  
             DNA  
             Homo sapiens  
           
            872 

atatagtttc gtcattcatc                                                 20 

 
           
             873  
             20  
             DNA  
             Homo sapiens  
           
            873 

tacattgccc atgtaattaa                                                 20 

 
           
             874  
             20  
             DNA  
             Homo sapiens  
           
            874 

atatagtttc gtcattcatc                                                 20 

 
           
             875  
             20  
             DNA  
             Homo sapiens  
           
            875 

tacattgccc atgtaattaa                                                 20 

 
           
             876  
             20  
             DNA  
             Homo sapiens  
           
            876 

agatagtttt gtcattcatc                                                 20 

 
           
             877  
             20  
             DNA  
             Homo sapiens  
           
            877 

agatagtttc ttcattcatc                                                 20 

 
           
             878  
             20  
             DNA  
             Homo sapiens  
           
            878 

agatagtttc gtcattcatc                                                 20 

 
           
             879  
             20  
             DNA  
             Homo sapiens  
           
            879 

agatagtttc gttattcatc                                                 20 

 
           
             880  
             21  
             DNA  
             Homo sapiens  
           
            880 

cccctctcat tcatcgcccg c                                               21 

 
           
             881  
             21  
             DNA  
             Homo sapiens  
           
            881 

ccctctcatc tatcgcccgc c                                               21 

 
           
             882  
             21  
             DNA  
             Homo sapiens  
           
            882 

cctctcatcc ttcgcccgcc g                                               21 

 
           
             883  
             21  
             DNA  
             Homo sapiens  
           
            883 

ctctcatcca tcgcccgccg c                                               21 

 
           
             884  
             21  
             DNA  
             Homo sapiens  
           
            884 

tctcatccat tgcccgccgc c                                               21 

 
           
             885  
             21  
             DNA  
             Homo sapiens  
           
            885 

ctcatccatc tcccgccgcc c                                               21 

 
           
             886  
             21  
             DNA  
             Homo sapiens  
           
            886 

tcatccatcg tccgccgccc c                                               21 

 
           
             887  
             21  
             DNA  
             Homo sapiens  
           
            887 

catccatcgc tcgccgcccc t                                               21 

 
           
             888  
             21  
             DNA  
             Homo sapiens  
           
            888 

atccatcgcc tgccgcccct c                                               21 

 
           
             889  
             21  
             DNA  
             Homo sapiens  
           
            889 

tccatcgccc tccgcccctc a                                               21 

 
           
             890  
             21  
             DNA  
             Homo sapiens  
           
            890 

ccatcgcccg tcgcccctca t                                               21 

 
           
             891  
             21  
             DNA  
             Homo sapiens  
           
            891 

catcgcccgc tgcccctcat c                                               21 

 
           
             892  
             21  
             DNA  
             Homo sapiens  
           
            892 

atcgcccgcc tcccctcatc a                                               21 

 
           
             893  
             21  
             DNA  
             Homo sapiens  
           
            893 

tcgcccgccg tccctcatca t                                               21 

 
           
             894  
             21  
             DNA  
             Homo sapiens  
           
            894 

cgcccgccgc tcctcatcat a                                               21 

 
           
             895  
             21  
             DNA  
             Homo sapiens  
           
            895 

gcccgccgcc tctcatcata c                                               21 

 
           
             896  
             21  
             DNA  
             Homo sapiens  
           
            896 

cccgccgccc ttcatcatac c                                               21 

 
           
             897  
             21  
             DNA  
             Homo sapiens  
           
            897 

ccgccgcccc tcatcatacc t                                               21 

 
           
             898  
             21  
             DNA  
             Homo sapiens  
           
            898 

cgccgcccct tatcatacct c                                               21 

 
           
             899  
             21  
             DNA  
             Homo sapiens  
           
            899 

gccgcccctc ttcatacctc a                                               21 

 
           
             900  
             21  
             DNA  
             Homo sapiens  
           
            900 

ccgcccctca tcatacctca g                                               21 

 
           
             901  
             21  
             DNA  
             Homo sapiens  
           
            901 

gcctctcccc gtctcatcca t                                               21 

 
           
             902  
             21  
             DNA  
             Homo sapiens  
           
            902 

cctctccccc gctcatccat c                                               21 

 
           
             903  
             21  
             DNA  
             Homo sapiens  
           
            903 

ctctccccct gtcatccatc g                                               21 

 
           
             904  
             21  
             DNA  
             Homo sapiens  
           
            904 

tctccccctc gcatccatcg c                                               21 

 
           
             905  
             21  
             DNA  
             Homo sapiens  
           
            905 

ctccccctct gatccatcgc c                                               21 

 
           
             906  
             21  
             DNA  
             Homo sapiens  
           
            906 

tccccctctc gtccatcgcc c                                               21 

 
           
             907  
             21  
             DNA  
             Homo sapiens  
           
            907 

ccccctctca gccatcgccc g                                               21 

 
           
             908  
             20  
             DNA  
             Homo sapiens  
           
            908 

tacattgccc atgtaattaa                                                 20 

 
           
             909  
             20  
             DNA  
             Homo sapiens  
           
            909 

atatagtttc gtcattcatc                                                 20 

 
           
             910  
             20  
             DNA  
             Homo sapiens  
           
            910 

tacattgccc atgtaattaa                                                 20 

 
           
             911  
             20  
             DNA  
             Homo sapiens  
           
            911 

atatagtttc gtcattcatc                                                 20 

 
           
             912  
             20  
             DNA  
             Homo sapiens  
           
            912 

agatagtttg gtcattcatc                                                 20 

 
           
             913  
             20  
             DNA  
             Homo sapiens  
           
            913 

agatagtttc gtcattcatc                                                 20 

 
           
             914  
             20  
             DNA  
             Homo sapiens  
           
            914 

agatagtttc ggcattcatc                                                 20 

 
           
             915  
             20  
             DNA  
             Homo sapiens  
           
            915 

agatagtttc gtgattcatc                                                 20 

 
           
             916  
             21  
             DNA  
             Homo sapiens  
           
            916 

cccctctcat gcatcgcccg c                                               21 

 
           
             917  
             21  
             DNA  
             Homo sapiens  
           
            917 

ccctctcatc gatcgcccgc c                                               21 

 
           
             918  
             21  
             DNA  
             Homo sapiens  
           
            918 

cctctcatcc gtcgcccgcc g                                               21 

 
           
             919  
             21  
             DNA  
             Homo sapiens  
           
            919 

ctctcatcca gcgcccgccg c                                               21 

 
           
             920  
             21  
             DNA  
             Homo sapiens  
           
            920 

tctcatccat ggcccgccgc c                                               21 

 
           
             921  
             21  
             DNA  
             Homo sapiens  
           
            921 

ctcatccatc gcccgccgcc c                                               21 

 
           
             922  
             21  
             DNA  
             Homo sapiens  
           
            922 

tcatccatcg gccgccgccc c                                               21 

 
           
             923  
             21  
             DNA  
             Homo sapiens  
           
            923 

catccatcgc gcgccgcccc t                                               21 

 
           
             924  
             21  
             DNA  
             Homo sapiens  
           
            924 

atccatcgcc ggccgcccct c                                               21 

 
           
             925  
             21  
             DNA  
             Homo sapiens  
           
            925 

tccatcgccc gccgcccctc a                                               21 

 
           
             926  
             21  
             DNA  
             Homo sapiens  
           
            926 

ccatcgcccg gcgcccctca t                                               21 

 
           
             927  
             21  
             DNA  
             Homo sapiens  
           
            927 

catcgcccgc ggcccctcat c                                               21 

 
           
             928  
             21  
             DNA  
             Homo sapiens  
           
            928 

atcgcccgcc gcccctcatc a                                               21 

 
           
             929  
             21  
             DNA  
             Homo sapiens  
           
            929 

tcgcccgccg gccctcatca t                                               21 

 
           
             930  
             21  
             DNA  
             Homo sapiens  
           
            930 

cgcccgccgc gcctcatcat a                                               21 

 
           
             931  
             21  
             DNA  
             Homo sapiens  
           
            931 

gcccgccgcc gctcatcata c                                               21 

 
           
             932  
             21  
             DNA  
             Homo sapiens  
           
            932 

cccgccgccc gtcatcatac c                                               21 

 
           
             933  
             21  
             DNA  
             Homo sapiens  
           
            933 

ccgccgcccc gcatcatacc t                                               21 

 
           
             934  
             21  
             DNA  
             Homo sapiens  
           
            934 

cgccgcccct gatcatacct c                                               21 

 
           
             935  
             21  
             DNA  
             Homo sapiens  
           
            935 

gccgcccctc gtcatacctc a                                               21 

 
           
             936  
             21  
             DNA  
             Homo sapiens  
           
            936 

ccgcccctca gcatacctca g                                               21 

 
           
             937  
             21  
             DNA  
             Homo sapiens  
           
            937 

gcctctcccc ctctcatcca t                                               21 

 
           
             938  
             21  
             DNA  
             Homo sapiens  
           
            938 

cctctccccc cctcatccat c                                               21 

 
           
             939  
             21  
             DNA  
             Homo sapiens  
           
            939 

ctctccccct ctcatccatc g                                               21 

 
           
             940  
             21  
             DNA  
             Homo sapiens  
           
            940 

tctccccctc ccatccatcg c                                               21 

 
           
             941  
             21  
             DNA  
             Homo sapiens  
           
            941 

ctccccctct catccatcgc c                                               21 

 
           
             942  
             21  
             DNA  
             Homo sapiens  
           
            942 

tccccctctc ctccatcgcc c                                               21 

 
           
             943  
             21  
             DNA  
             Homo sapiens  
           
            943 

ccccctctca cccatcgccc g                                               21 

 
           
             944  
             20  
             DNA  
             Homo sapiens  
           
            944 

atatagtttc gtcattcatc                                                 20 

 
           
             945  
             20  
             DNA  
             Homo sapiens  
           
            945 

tacattgccc atgtaattaa                                                 20 

 
           
             946  
             20  
             DNA  
             Homo sapiens  
           
            946 

atatagtttc gtcattcatc                                                 20 

 
           
             947  
             20  
             DNA  
             Homo sapiens  
           
            947 

tacattgccc atgtaattaa                                                 20 

 
           
             948  
             20  
             DNA  
             Homo sapiens  
           
            948 

agatagtttc gtcattcatc                                                 20 

 
           
             949  
             20  
             DNA  
             Homo sapiens  
           
            949 

agatagtttc ctcattcatc                                                 20 

 
           
             950  
             20  
             DNA  
             Homo sapiens  
           
            950 

agatagtttc gccattcatc                                                 20 

 
           
             951  
             20  
             DNA  
             Homo sapiens  
           
            951 

agatagtttc gtcattcatc                                                 20 

 
           
             952  
             21  
             DNA  
             Homo sapiens  
           
            952 

cccctctcat ccatcgcccg c                                               21 

 
           
             953  
             21  
             DNA  
             Homo sapiens  
           
            953 

ccctctcatc catcgcccgc c                                               21 

 
           
             954  
             21  
             DNA  
             Homo sapiens  
           
            954 

cctctcatcc ctcgcccgcc g                                               21 

 
           
             955  
             21  
             DNA  
             Homo sapiens  
           
            955 

ctctcatcca ccgcccgccg c                                               21 

 
           
             956  
             21  
             DNA  
             Homo sapiens  
           
            956 

tctcatccat cgcccgccgc c                                               21 

 
           
             957  
             21  
             DNA  
             Homo sapiens  
           
            957 

ctcatccatc ccccgccgcc c                                               21 

 
           
             958  
             21  
             DNA  
             Homo sapiens  
           
            958 

tcatccatcg cccgccgccc c                                               21 

 
           
             959  
             21  
             DNA  
             Homo sapiens  
           
            959 

catccatcgc ccgccgcccc t                                               21 

 
           
             960  
             21  
             DNA  
             Homo sapiens  
           
            960 

atccatcgcc cgccgcccct c                                               21 

 
           
             961  
             21  
             DNA  
             Homo sapiens  
           
            961 

tccatcgccc cccgcccctc a                                               21 

 
           
             962  
             21  
             DNA  
             Homo sapiens  
           
            962 

ccatcgcccg ccgcccctca t                                               21 

 
           
             963  
             21  
             DNA  
             Homo sapiens  
           
            963 

catcgcccgc cgcccctcat c                                               21 

 
           
             964  
             21  
             DNA  
             Homo sapiens  
           
            964 

atcgcccgcc ccccctcatc a                                               21 

 
           
             965  
             21  
             DNA  
             Homo sapiens  
           
            965 

tcgcccgccg cccctcatca t                                               21 

 
           
             966  
             21  
             DNA  
             Homo sapiens  
           
            966 

cgcccgccgc ccctcatcat a                                               21 

 
           
             967  
             21  
             DNA  
             Homo sapiens  
           
            967 

gcccgccgcc cctcatcata c                                               21 

 
           
             968  
             21  
             DNA  
             Homo sapiens  
           
            968 

cccgccgccc ctcatcatac c                                               21 

 
           
             969  
             21  
             DNA  
             Homo sapiens  
           
            969 

ccgccgcccc ccatcatacc t                                               21 

 
           
             970  
             21  
             DNA  
             Homo sapiens  
           
            970 

cgccgcccct catcatacct c                                               21 

 
           
             971  
             21  
             DNA  
             Homo sapiens  
           
            971 

gccgcccctc ctcatacctc a                                               21 

 
           
             972  
             21  
             DNA  
             Homo sapiens  
           
            972 

ccgcccctca ccatacctca g                                               21 

 
           
             973  
             21  
             DNA  
             Homo sapiens  
           
            973 

gcctctcccc atctcatcca t                                               21 

 
           
             974  
             21  
             DNA  
             Homo sapiens  
           
            974 

cctctccccc actcatccat c                                               21 

 
           
             975  
             21  
             DNA  
             Homo sapiens  
           
            975 

ctctccccct atcatccatc g                                               21 

 
           
             976  
             21  
             DNA  
             Homo sapiens  
           
            976 

tctccccctc acatccatcg c                                               21 

 
           
             977  
             21  
             DNA  
             Homo sapiens  
           
            977 

ctccccctct aatccatcgc c                                               21 

 
           
             978  
             21  
             DNA  
             Homo sapiens  
           
            978 

tccccctctc atccatcgcc c                                               21 

 
           
             979  
             21  
             DNA  
             Homo sapiens  
           
            979 

ccccctctca accatcgccc g                                               21 

 
           
             980  
             20  
             DNA  
             Homo sapiens  
           
            980 

tacattgccc atgtaattaa                                                 20 

 
           
             981  
             20  
             DNA  
             Homo sapiens  
           
            981 

atatagtttc gtcattcatc                                                 20 

 
           
             982  
             20  
             DNA  
             Homo sapiens  
           
            982 

tacattgccc atgtaattaa                                                 20 

 
           
             983  
             20  
             DNA  
             Homo sapiens  
           
            983 

atatagtttc gtcattcatc                                                 20 

 
           
             984  
             20  
             DNA  
             Homo sapiens  
           
            984 

agatagttta gtcattcatc                                                 20 

 
           
             985  
             20  
             DNA  
             Homo sapiens  
           
            985 

agatagtttc atcattcatc                                                 20 

 
           
             986  
             20  
             DNA  
             Homo sapiens  
           
            986 

agatagtttc gacattcatc                                                 20 

 
           
             987  
             20  
             DNA  
             Homo sapiens  
           
            987 

agatagtttc gtaattcatc                                                 20 

 
           
             988  
             21  
             DNA  
             Homo sapiens  
           
            988 

cccctctcat acatcgcccg c                                               21 

 
           
             989  
             21  
             DNA  
             Homo sapiens  
           
            989 

ccctctcatc aatcgcccgc c                                               21 

 
           
             990  
             21  
             DNA  
             Homo sapiens  
           
            990 

cctctcatcc atcgcccgcc g                                               21 

 
           
             991  
             21  
             DNA  
             Homo sapiens  
           
            991 

ctctcatcca acgcccgccg c                                               21 

 
           
             992  
             21  
             DNA  
             Homo sapiens  
           
            992 

tctcatccat agcccgccgc c                                               21 

 
           
             993  
             21  
             DNA  
             Homo sapiens  
           
            993 

ctcatccatc acccgccgcc c                                               21 

 
           
             994  
             21  
             DNA  
             Homo sapiens  
           
            994 

tcatccatcg accgccgccc c                                               21 

 
           
             995  
             21  
             DNA  
             Homo sapiens  
           
            995 

catccatcgc acgccgcccc t                                               21 

 
           
             996  
             21  
             DNA  
             Homo sapiens  
           
            996 

atccatcgcc agccgcccct c                                               21 

 
           
             997  
             21  
             DNA  
             Homo sapiens  
           
            997 

tccatcgccc accgcccctc a                                               21 

 
           
             998  
             21  
             DNA  
             Homo sapiens  
           
            998 

ccatcgcccg acgcccctca t                                               21 

 
           
             999  
             21  
             DNA  
             Homo sapiens  
           
            999 

catcgcccgc agcccctcat c                                               21 

 
           
             1000  
             21  
             DNA  
             Homo sapiens  
           
            1000 

atcgcccgcc acccctcatc a                                               21 

 
           
             1001  
             21  
             DNA  
             Homo sapiens  
           
            1001 

tcgcccgccg accctcatca t                                               21 

 
           
             1002  
             21  
             DNA  
             Homo sapiens  
           
            1002 

cgcccgccgc acctcatcat a                                               21 

 
           
             1003  
             21  
             DNA  
             Homo sapiens  
           
            1003 

gcccgccgcc actcatcata c                                               21 

 
           
             1004  
             21  
             DNA  
             Homo sapiens  
           
            1004 

cccgccgccc atcatcatac c                                               21 

 
           
             1005  
             21  
             DNA  
             Homo sapiens  
           
            1005 

ccgccgcccc acatcatacc t                                               21 

 
           
             1006  
             21  
             DNA  
             Homo sapiens  
           
            1006 

cgccgcccct aatcatacct c                                               21 

 
           
             1007  
             21  
             DNA  
             Homo sapiens  
           
            1007 

gccgcccctc atcatacctc a                                               21 

 
           
             1008  
             21  
             DNA  
             Homo sapiens  
           
            1008 

ccgcccctca acatacctca g                                               21 

 
           
             1009  
             21  
             DNA  
             Homo sapiens  
           
            1009 

cgcccctcat tatacctcag c                                               21 

 
           
             1010  
             21  
             DNA  
             Homo sapiens  
           
            1010 

gcccctcatc ttacctcagc c                                               21 

 
           
             1011  
             21  
             DNA  
             Homo sapiens  
           
            1011 

cccctcatca tacctcagcc g                                               21 

 
           
             1012  
             21  
             DNA  
             Homo sapiens  
           
            1012 

ccctcatcat tcctcagccg c                                               21 

 
           
             1013  
             20  
             DNA  
             Homo sapiens  
           
            1013 

atatagtttc gtcattcatc                                                 20 

 
           
             1014  
             20  
             DNA  
             Homo sapiens  
           
            1014 

tacattgccc atgtaattaa                                                 20 

 
           
             1015  
             20  
             DNA  
             Homo sapiens  
           
            1015 

atatagtttc gtcattcatc                                                 20 

 
           
             1016  
             20  
             DNA  
             Homo sapiens  
           
            1016 

tacattgccc atgtaattaa                                                 20 

 
           
             1017  
             20  
             DNA  
             Homo sapiens  
           
            1017 

agatagtttt gtcattcatc                                                 20 

 
           
             1018  
             20  
             DNA  
             Homo sapiens  
           
            1018 

agatagtttc ttcattcatc                                                 20 

 
           
             1019  
             20  
             DNA  
             Homo sapiens  
           
            1019 

agatagtttc gtcattcatc                                                 20 

 
           
             1020  
             20  
             DNA  
             Homo sapiens  
           
            1020 

agatagtttc gttattcatc                                                 20 

 
           
             1021  
             21  
             DNA  
             Homo sapiens  
           
            1021 

cctcatcata tctcagccgc c                                               21 

 
           
             1022  
             21  
             DNA  
             Homo sapiens  
           
            1022 

ctcatcatac ttcagccgcc g                                               21 

 
           
             1023  
             21  
             DNA  
             Homo sapiens  
           
            1023 

tcatcatacc tcagccgccg c                                               21 

 
           
             1024  
             21  
             DNA  
             Homo sapiens  
           
            1024 

catcatacct tagccgccgc c                                               21 

 
           
             1025  
             21  
             DNA  
             Homo sapiens  
           
            1025 

atcatacctc tgccgccgcc c                                               21 

 
           
             1026  
             21  
             DNA  
             Homo sapiens  
           
            1026 

tcatacctca tccgccgccc c                                               21 

 
           
             1027  
             21  
             DNA  
             Homo sapiens  
           
            1027 

catacctcag tcgccgcccc t                                               21 

 
           
             1028  
             21  
             DNA  
             Homo sapiens  
           
            1028 

atacctcagc tgccgcccct c                                               21 

 
           
             1029  
             21  
             DNA  
             Homo sapiens  
           
            1029 

tacctcagcc tccgcccctc a                                               21 

 
           
             1030  
             21  
             DNA  
             Homo sapiens  
           
            1030 

acctcagccg tcgcccctca t                                               21 

 
           
             1031  
             21  
             DNA  
             Homo sapiens  
           
            1031 

cctcagccgc tgcccctcat c                                               21 

 
           
             1032  
             21  
             DNA  
             Homo sapiens  
           
            1032 

ctcagccgcc tcccctcatc a                                               21 

 
           
             1033  
             21  
             DNA  
             Homo sapiens  
           
            1033 

tcagccgccg tccctcatca t                                               21 

 
           
             1034  
             21  
             DNA  
             Homo sapiens  
           
            1034 

cagccgccgc tcctcatcat a                                               21 

 
           
             1035  
             21  
             DNA  
             Homo sapiens  
           
            1035 

agccgccgcc tctcatcata c                                               21 

 
           
             1036  
             21  
             DNA  
             Homo sapiens  
           
            1036 

gccgccgccc ttcatcatac c                                               21 

 
           
             1037  
             21  
             DNA  
             Homo sapiens  
           
            1037 

ccgccgcccc tcatcatacc t                                               21 

 
           
             1038  
             21  
             DNA  
             Homo sapiens  
           
            1038 

cgccgcccct tatcatacct c                                               21 

 
           
             1039  
             21  
             DNA  
             Homo sapiens  
           
            1039 

gccgcccctc ttcatacctc a                                               21 

 
           
             1040  
             21  
             DNA  
             Homo sapiens  
           
            1040 

ccgcccctca tcatacctca a                                               21 

 
           
             1041  
             21  
             DNA  
             Homo sapiens  
           
            1041 

cgcccctcat tatacctcaa a                                               21 

 
           
             1042  
             21  
             DNA  
             Homo sapiens  
           
            1042 

gcccctcatc ttacctcaaa a                                               21 

 
           
             1043  
             21  
             DNA  
             Homo sapiens  
           
            1043 

cccctcatca tacctcaaaa g                                               21 

 
           
             1044  
             21  
             DNA  
             Homo sapiens  
           
            1044 

ccctcatcat tcctcaaaag c                                               21 

 
           
             1045  
             21  
             DNA  
             Homo sapiens  
           
            1045 

cgcccctcat gatacctcag c                                               21 

 
           
             1046  
             21  
             DNA  
             Homo sapiens  
           
            1046 

gcccctcatc gtacctcagc c                                               21 

 
           
             1047  
             21  
             DNA  
             Homo sapiens  
           
            1047 

cccctcatca gacctcagcc g                                               21 

 
           
             1048  
             21  
             DNA  
             Homo sapiens  
           
            1048 

ccctcatcat gcctcagccg c                                               21 

 
           
             1049  
             20  
             DNA  
             Homo sapiens  
           
            1049 

tacattgccc atgtaattaa                                                 20 

 
           
             1050  
             20  
             DNA  
             Homo sapiens  
           
            1050 

atatagtttc gtcattcatc                                                 20 

 
           
             1051  
             20  
             DNA  
             Homo sapiens  
           
            1051 

tacattgccc atgtaattaa                                                 20 

 
           
             1052  
             20  
             DNA  
             Homo sapiens  
           
            1052 

atatagtttc gtcattcatc                                                 20 

 
           
             1053  
             20  
             DNA  
             Homo sapiens  
           
            1053 

agatagtttg gtcattcatc                                                 20 

 
           
             1054  
             20  
             DNA  
             Homo sapiens  
           
            1054 

agatagtttc gtcattcatc                                                 20 

 
           
             1055  
             20  
             DNA  
             Homo sapiens  
           
            1055 

agatagtttc ggcattcatc                                                 20 

 
           
             1056  
             20  
             DNA  
             Homo sapiens  
           
            1056 

agatagtttc gtgattcatc                                                 20 

 
           
             1057  
             21  
             DNA  
             Homo sapiens  
           
            1057 

cctcatcata gctcagccgc c                                               21 

 
           
             1058  
             21  
             DNA  
             Homo sapiens  
           
            1058 

ctcatcatac gtcagccgcc g                                               21 

 
           
             1059  
             21  
             DNA  
             Homo sapiens  
           
            1059 

tcatcatacc gcagccgccg c                                               21 

 
           
             1060  
             21  
             DNA  
             Homo sapiens  
           
            1060 

catcatacct gagccgccgc c                                               21 

 
           
             1061  
             21  
             DNA  
             Homo sapiens  
           
            1061 

atcatacctc ggccgccgcc c                                               21 

 
           
             1062  
             21  
             DNA  
             Homo sapiens  
           
            1062 

tcatacctca gccgccgccc c                                               21 

 
           
             1063  
             21  
             DNA  
             Homo sapiens  
           
            1063 

catacctcag gcgccgcccc t                                               21 

 
           
             1064  
             21  
             DNA  
             Homo sapiens  
           
            1064 

atacctcagc ggccgcccct c                                               21 

 
           
             1065  
             21  
             DNA  
             Homo sapiens  
           
            1065 

tacctcagcc gccgcccctc a                                               21 

 
           
             1066  
             21  
             DNA  
             Homo sapiens  
           
            1066 

acctcagccg gcgcccctca t                                               21 

 
           
             1067  
             21  
             DNA  
             Homo sapiens  
           
            1067 

cctcagccgc ggcccctcat c                                               21 

 
           
             1068  
             21  
             DNA  
             Homo sapiens  
           
            1068 

ctcagccgcc gcccctcatc a                                               21 

 
           
             1069  
             21  
             DNA  
             Homo sapiens  
           
            1069 

tcagccgccg gccctcatca t                                               21 

 
           
             1070  
             21  
             DNA  
             Homo sapiens  
           
            1070 

cagccgccgc gcctcatcat a                                               21 

 
           
             1071  
             21  
             DNA  
             Homo sapiens  
           
            1071 

agccgccgcc gctcatcata c                                               21 

 
           
             1072  
             21  
             DNA  
             Homo sapiens  
           
            1072 

gccgccgccc gtcatcatac c                                               21 

 
           
             1073  
             21  
             DNA  
             Homo sapiens  
           
            1073 

ccgccgcccc gcatcatacc t                                               21 

 
           
             1074  
             21  
             DNA  
             Homo sapiens  
           
            1074 

cgccgcccct gatcatacct c                                               21 

 
           
             1075  
             21  
             DNA  
             Homo sapiens  
           
            1075 

gccgcccctc gtcatacctc a                                               21 

 
           
             1076  
             21  
             DNA  
             Homo sapiens  
           
            1076 

ccgcccctca gcatacctca a                                               21 

 
           
             1077  
             21  
             DNA  
             Homo sapiens  
           
            1077 

cgcccctcat gatacctcaa a                                               21 

 
           
             1078  
             21  
             DNA  
             Homo sapiens  
           
            1078 

gcccctcatc gtacctcaaa a                                               21 

 
           
             1079  
             21  
             DNA  
             Homo sapiens  
           
            1079 

cccctcatca gacctcaaaa g                                               21 

 
           
             1080  
             21  
             DNA  
             Homo sapiens  
           
            1080 

ccctcatcat gcctcaaaag c                                               21 

 
           
             1081  
             21  
             DNA  
             Homo sapiens  
           
            1081 

cgcccctcat catacctcag c                                               21 

 
           
             1082  
             21  
             DNA  
             Homo sapiens  
           
            1082 

gcccctcatc ctacctcagc c                                               21 

 
           
             1083  
             21  
             DNA  
             Homo sapiens  
           
            1083 

cccctcatca cacctcagcc g                                               21 

 
           
             1084  
             21  
             DNA  
             Homo sapiens  
           
            1084 

ccctcatcat ccctcagccg c                                               21 

 
           
             1085  
             20  
             DNA  
             Homo sapiens  
           
            1085 

atatagtttc gtcattcatc                                                 20 

 
           
             1086  
             20  
             DNA  
             Homo sapiens  
           
            1086 

tacattgccc atgtaattaa                                                 20 

 
           
             1087  
             20  
             DNA  
             Homo sapiens  
           
            1087 

atatagtttc gtcattcatc                                                 20 

 
           
             1088  
             20  
             DNA  
             Homo sapiens  
           
            1088 

tacattgccc atgtaattaa                                                 20 

 
           
             1089  
             20  
             DNA  
             Homo sapiens  
           
            1089 

agatagtttc gtcattcatc                                                 20 

 
           
             1090  
             20  
             DNA  
             Homo sapiens  
           
            1090 

agatagtttc ctcattcatc                                                 20 

 
           
             1091  
             20  
             DNA  
             Homo sapiens  
           
            1091 

agatagtttc gccattcatc                                                 20 

 
           
             1092  
             20  
             DNA  
             Homo sapiens  
           
            1092 

agatagtttc gtcattcatc                                                 20 

 
           
             1093  
             21  
             DNA  
             Homo sapiens  
           
            1093 

cctcatcata cctcagccgc c                                               21 

 
           
             1094  
             21  
             DNA  
             Homo sapiens  
           
            1094 

ctcatcatac ctcagccgcc g                                               21 

 
           
             1095  
             21  
             DNA  
             Homo sapiens  
           
            1095 

tcatcatacc ccagccgccg c                                               21 

 
           
             1096  
             21  
             DNA  
             Homo sapiens  
           
            1096 

catcatacct cagccgccgc c                                               21 

 
           
             1097  
             21  
             DNA  
             Homo sapiens  
           
            1097 

atcatacctc cgccgccgcc c                                               21 

 
           
             1098  
             21  
             DNA  
             Homo sapiens  
           
            1098 

tcatacctca cccgccgccc c                                               21 

 
           
             1099  
             21  
             DNA  
             Homo sapiens  
           
            1099 

catacctcag ccgccgcccc t                                               21 

 
           
             1100  
             21  
             DNA  
             Homo sapiens  
           
            1100 

atacctcagc cgccgcccct c                                               21 

 
           
             1101  
             21  
             DNA  
             Homo sapiens  
           
            1101 

tacctcagcc cccgcccctc a                                               21 

 
           
             1102  
             21  
             DNA  
             Homo sapiens  
           
            1102 

acctcagccg ccgcccctca t                                               21 

 
           
             1103  
             21  
             DNA  
             Homo sapiens  
           
            1103 

cctcagccgc cgcccctcat c                                               21 

 
           
             1104  
             21  
             DNA  
             Homo sapiens  
           
            1104 

ctcagccgcc ccccctcatc a                                               21 

 
           
             1105  
             21  
             DNA  
             Homo sapiens  
           
            1105 

tcagccgccg cccctcatca t                                               21 

 
           
             1106  
             21  
             DNA  
             Homo sapiens  
           
            1106 

cagccgccgc ccctcatcat a                                               21 

 
           
             1107  
             21  
             DNA  
             Homo sapiens  
           
            1107 

agccgccgcc cctcatcata c                                               21 

 
           
             1108  
             21  
             DNA  
             Homo sapiens  
           
            1108 

gccgccgccc ctcatcatac c                                               21 

 
           
             1109  
             21  
             DNA  
             Homo sapiens  
           
            1109 

ccgccgcccc ccatcatacc t                                               21 

 
           
             1110  
             21  
             DNA  
             Homo sapiens  
           
            1110 

cgccgcccct catcatacct c                                               21 

 
           
             1111  
             21  
             DNA  
             Homo sapiens  
           
            1111 

gccgcccctc ctcatacctc a                                               21 

 
           
             1112  
             21  
             DNA  
             Homo sapiens  
           
            1112 

ccgcccctca ccatacctca a                                               21 

 
           
             1113  
             21  
             DNA  
             Homo sapiens  
           
            1113 

cgcccctcat catacctcaa a                                               21 

 
           
             1114  
             21  
             DNA  
             Homo sapiens  
           
            1114 

gcccctcatc ctacctcaaa a                                               21 

 
           
             1115  
             21  
             DNA  
             Homo sapiens  
           
            1115 

cccctcatca cacctcaaaa g                                               21 

 
           
             1116  
             21  
             DNA  
             Homo sapiens  
           
            1116 

ccctcatcat ccctcaaaag c                                               21 

 
           
             1117  
             21  
             DNA  
             Homo sapiens  
           
            1117 

cgcccctcat aatacctcag c                                               21 

 
           
             1118  
             21  
             DNA  
             Homo sapiens  
           
            1118 

gcccctcatc atacctcagc c                                               21 

 
           
             1119  
             21  
             DNA  
             Homo sapiens  
           
            1119 

cccctcatca aacctcagcc g                                               21 

 
           
             1120  
             21  
             DNA  
             Homo sapiens  
           
            1120 

ccctcatcat acctcagccg c                                               21 

 
           
             1121  
             20  
             DNA  
             Homo sapiens  
           
            1121 

tacattgccc atgtaattaa                                                 20 

 
           
             1122  
             20  
             DNA  
             Homo sapiens  
           
            1122 

atatagtttc gtcattcatc                                                 20 

 
           
             1123  
             20  
             DNA  
             Homo sapiens  
           
            1123 

tacattgccc atgtaattaa                                                 20 

 
           
             1124  
             20  
             DNA  
             Homo sapiens  
           
            1124 

atatagtttc gtcattcatc                                                 20 

 
           
             1125  
             20  
             DNA  
             Homo sapiens  
           
            1125 

agatagttta gtcattcatc                                                 20 

 
           
             1126  
             20  
             DNA  
             Homo sapiens  
           
            1126 

agatagtttc atcattcatc                                                 20 

 
           
             1127  
             20  
             DNA  
             Homo sapiens  
           
            1127 

agatagtttc gacattcatc                                                 20 

 
           
             1128  
             20  
             DNA  
             Homo sapiens  
           
            1128 

agatagtttc gtaattcatc                                                 20 

 
           
             1129  
             21  
             DNA  
             Homo sapiens  
           
            1129 

cctcatcata actcagccgc c                                               21 

 
           
             1130  
             21  
             DNA  
             Homo sapiens  
           
            1130 

ctcatcatac atcagccgcc g                                               21 

 
           
             1131  
             21  
             DNA  
             Homo sapiens  
           
            1131 

tcatcatacc acagccgccg c                                               21 

 
           
             1132  
             21  
             DNA  
             Homo sapiens  
           
            1132 

catcatacct aagccgccgc c                                               21 

 
           
             1133  
             21  
             DNA  
             Homo sapiens  
           
            1133 

atcatacctc agccgccgcc c                                               21 

 
           
             1134  
             21  
             DNA  
             Homo sapiens  
           
            1134 

tcatacctca accgccgccc c                                               21 

 
           
             1135  
             21  
             DNA  
             Homo sapiens  
           
            1135 

catacctcag acgccgcccc t                                               21 

 
           
             1136  
             21  
             DNA  
             Homo sapiens  
           
            1136 

atacctcagc agccgcccct c                                               21 

 
           
             1137  
             21  
             DNA  
             Homo sapiens  
           
            1137 

tacctcagcc accgcccctc a                                               21 

 
           
             1138  
             21  
             DNA  
             Homo sapiens  
           
            1138 

acctcagccg acgcccctca t                                               21 

 
           
             1139  
             21  
             DNA  
             Homo sapiens  
           
            1139 

cctcagccgc agcccctcat c                                               21 

 
           
             1140  
             21  
             DNA  
             Homo sapiens  
           
            1140 

ctcagccgcc acccctcatc a                                               21 

 
           
             1141  
             21  
             DNA  
             Homo sapiens  
           
            1141 

tcagccgccg accctcatca t                                               21 

 
           
             1142  
             21  
             DNA  
             Homo sapiens  
           
            1142 

cagccgccgc acctcatcat a                                               21 

 
           
             1143  
             21  
             DNA  
             Homo sapiens  
           
            1143 

agccgccgcc actcatcata c                                               21 

 
           
             1144  
             21  
             DNA  
             Homo sapiens  
           
            1144 

gccgccgccc atcatcatac c                                               21 

 
           
             1145  
             21  
             DNA  
             Homo sapiens  
           
            1145 

ccgccgcccc acatcatacc t                                               21 

 
           
             1146  
             21  
             DNA  
             Homo sapiens  
           
            1146 

cgccgcccct aatcatacct c                                               21 

 
           
             1147  
             21  
             DNA  
             Homo sapiens  
           
            1147 

gccgcccctc atcatacctc a                                               21 

 
           
             1148  
             21  
             DNA  
             Homo sapiens  
           
            1148 

ccgcccctca acatacctca a                                               21 

 
           
             1149  
             21  
             DNA  
             Homo sapiens  
           
            1149 

cgcccctcat aatacctcaa a                                               21 

 
           
             1150  
             21  
             DNA  
             Homo sapiens  
           
            1150 

gcccctcatc atacctcaaa a                                               21 

 
           
             1151  
             21  
             DNA  
             Homo sapiens  
           
            1151 

cccctcatca aacctcaaaa g                                               21 

 
           
             1152  
             21  
             DNA  
             Homo sapiens  
           
            1152 

ccctcatcat acctcaaaag c                                               21 

 
           
             1153  
             21  
             DNA  
             Homo sapiens  
           
            1153 

cctcatcata tctcaaaagc c                                               21 

 
           
             1154  
             20  
             DNA  
             Homo sapiens  
           
            1154 

atatagtttc gtcattcatc                                                 20 

 
           
             1155  
             20  
             DNA  
             Homo sapiens  
           
            1155 

tacattgccc atgtaattaa                                                 20 

 
           
             1156  
             20  
             DNA  
             Homo sapiens  
           
            1156 

atatagtttc gtcattcatc                                                 20 

 
           
             1157  
             20  
             DNA  
             Homo sapiens  
           
            1157 

tacattgccc atgtaattaa                                                 20 

 
           
             1158  
             20  
             DNA  
             Homo sapiens  
           
            1158 

agatagtttt gtcattcatc                                                 20 

 
           
             1159  
             20  
             DNA  
             Homo sapiens  
           
            1159 

agatagtttc ttcattcatc                                                 20 

 
           
             1160  
             20  
             DNA  
             Homo sapiens  
           
            1160 

agatagtttc gtcattcatc                                                 20 

 
           
             1161  
             20  
             DNA  
             Homo sapiens  
           
            1161 

agatagtttc gttattcatc                                                 20 

 
           
             1162  
             21  
             DNA  
             Homo sapiens  
           
            1162 

ctcatcatac ttcaaaagcc a                                               21 

 
           
             1163  
             21  
             DNA  
             Homo sapiens  
           
            1163 

tcatcatacc tcaaaagcca a                                               21 

 
           
             1164  
             21  
             DNA  
             Homo sapiens  
           
            1164 

catcatacct taaaagccaa c                                               21 

 
           
             1165  
             21  
             DNA  
             Homo sapiens  
           
            1165 

atcatacctc taaagccaac t                                               21 

 
           
             1166  
             21  
             DNA  
             Homo sapiens  
           
            1166 

tcatacctca taagccaact a                                               21 

 
           
             1167  
             21  
             DNA  
             Homo sapiens  
           
            1167 

catacctcaa tagccaacta a                                               21 

 
           
             1168  
             21  
             DNA  
             Homo sapiens  
           
            1168 

atacctcaaa tgccaactaa c                                               21 

 
           
             1169  
             21  
             DNA  
             Homo sapiens  
           
            1169 

tacctcaaaa tccaactaac c                                               21 

 
           
             1170  
             21  
             DNA  
             Homo sapiens  
           
            1170 

acctcaaaag tcaactaacc a                                               21 

 
           
             1171  
             21  
             DNA  
             Homo sapiens  
           
            1171 

cctcaaaagc taactaacca a                                               21 

 
           
             1172  
             21  
             DNA  
             Homo sapiens  
           
            1172 

ctcaaaagcc tactaaccaa c                                               21 

 
           
             1173  
             21  
             DNA  
             Homo sapiens  
           
            1173 

tcaaaagcca tctaaccaac c                                               21 

 
           
             1174  
             21  
             DNA  
             Homo sapiens  
           
            1174 

caaaagccaa ttaaccaacc a                                               21 

 
           
             1175  
             21  
             DNA  
             Homo sapiens  
           
            1175 

aaaagccaac taaccaacca a                                               21 

 
           
             1176  
             21  
             DNA  
             Homo sapiens  
           
            1176 

aaagccaact taccaaccaa t                                               21 

 
           
             1177  
             20  
             DNA  
             Homo sapiens  
           
            1177 

atatagtttc gtcattcatc                                                 20 

 
           
             1178  
             20  
             DNA  
             Homo sapiens  
           
            1178 

tacattgccc atgtaattaa                                                 20 

 
           
             1179  
             20  
             DNA  
             Homo sapiens  
           
            1179 

atatagtttc gtcattcatc                                                 20 

 
           
             1180  
             20  
             DNA  
             Homo sapiens  
           
            1180 

tacattgccc atgtaattaa                                                 20 

 
           
             1181  
             20  
             DNA  
             Homo sapiens  
           
            1181 

agatagtttt gtcattcatc                                                 20 

 
           
             1182  
             20  
             DNA  
             Homo sapiens  
           
            1182 

agatagtttc ttcattcatc                                                 20 

 
           
             1183  
             20  
             DNA  
             Homo sapiens  
           
            1183 

agatagtttc gtcattcatc                                                 20 

 
           
             1184  
             20  
             DNA  
             Homo sapiens  
           
            1184 

agatagtttc gttattcatc                                                 20 

 
           
             1185  
             21  
             DNA  
             Homo sapiens  
           
            1185 

cctcatcata gctcaaaagc c                                               21 

 
           
             1186  
             20  
             DNA  
             Homo sapiens  
           
            1186 

tacattgccc atgtaattaa                                                 20 

 
           
             1187  
             20  
             DNA  
             Homo sapiens  
           
            1187 

atatagtttc gtcattcatc                                                 20 

 
           
             1188  
             20  
             DNA  
             Homo sapiens  
           
            1188 

tacattgccc atgtaattaa                                                 20 

 
           
             1189  
             20  
             DNA  
             Homo sapiens  
           
            1189 

atatagtttc gtcattcatc                                                 20 

 
           
             1190  
             20  
             DNA  
             Homo sapiens  
           
            1190 

agatagtttg gtcattcatc                                                 20 

 
           
             1191  
             20  
             DNA  
             Homo sapiens  
           
            1191 

agatagtttc gtcattcatc                                                 20 

 
           
             1192  
             20  
             DNA  
             Homo sapiens  
           
            1192 

agatagtttc ggcattcatc                                                 20 

 
           
             1193  
             20  
             DNA  
             Homo sapiens  
           
            1193 

agatagtttc gtgattcatc                                                 20 

 
           
             1194  
             21  
             DNA  
             Homo sapiens  
           
            1194 

ctcatcatac gtcaaaagcc a                                               21 

 
           
             1195  
             21  
             DNA  
             Homo sapiens  
           
            1195 

tcatcatacc gcaaaagcca a                                               21 

 
           
             1196  
             21  
             DNA  
             Homo sapiens  
           
            1196 

catcatacct gaaaagccaa c                                               21 

 
           
             1197  
             21  
             DNA  
             Homo sapiens  
           
            1197 

atcatacctc gaaagccaac t                                               21 

 
           
             1198  
             21  
             DNA  
             Homo sapiens  
           
            1198 

tcatacctca gaagccaact a                                               21 

 
           
             1199  
             21  
             DNA  
             Homo sapiens  
           
            1199 

catacctcaa gagccaacta a                                               21 

 
           
             1200  
             21  
             DNA  
             Homo sapiens  
           
            1200 

atacctcaaa ggccaactaa c                                               21 

 
           
             1201  
             21  
             DNA  
             Homo sapiens  
           
            1201 

tacctcaaaa gccaactaac c                                               21 

 
           
             1202  
             21  
             DNA  
             Homo sapiens  
           
            1202 

acctcaaaag gcaactaacc a                                               21 

 
           
             1203  
             21  
             DNA  
             Homo sapiens  
           
            1203 

cctcaaaagc gaactaacca a                                               21 

 
           
             1204  
             21  
             DNA  
             Homo sapiens  
           
            1204 

ctcaaaagcc gactaaccaa c                                               21 

 
           
             1205  
             21  
             DNA  
             Homo sapiens  
           
            1205 

tcaaaagcca gctaaccaac c                                               21 

 
           
             1206  
             21  
             DNA  
             Homo sapiens  
           
            1206 

caaaagccaa gtaaccaacc a                                               21 

 
           
             1207  
             21  
             DNA  
             Homo sapiens  
           
            1207 

aaaagccaac gaaccaacca a                                               21 

 
           
             1208  
             21  
             DNA  
             Homo sapiens  
           
            1208 

aaagccaact gaccaaccaa t                                               21 

 
           
             1209  
             20  
             DNA  
             Homo sapiens  
           
            1209 

tacattgccc atgtaattaa                                                 20 

 
           
             1210  
             20  
             DNA  
             Homo sapiens  
           
            1210 

atatagtttc gtcattcatc                                                 20 

 
           
             1211  
             20  
             DNA  
             Homo sapiens  
           
            1211 

tacattgccc atgtaattaa                                                 20 

 
           
             1212  
             20  
             DNA  
             Homo sapiens  
           
            1212 

atatagtttc gtcattcatc                                                 20 

 
           
             1213  
             20  
             DNA  
             Homo sapiens  
           
            1213 

agatagtttg gtcattcatc                                                 20 

 
           
             1214  
             20  
             DNA  
             Homo sapiens  
           
            1214 

agatagtttc gtcattcatc                                                 20 

 
           
             1215  
             20  
             DNA  
             Homo sapiens  
           
            1215 

agatagtttc ggcattcatc                                                 20 

 
           
             1216  
             20  
             DNA  
             Homo sapiens  
           
            1216 

agatagtttc gtgattcatc                                                 20 

 
           
             1217  
             21  
             DNA  
             Homo sapiens  
           
            1217 

cctcatcata cctcaaaagc c                                               21 

 
           
             1218  
             20  
             DNA  
             Homo sapiens  
           
            1218 

atatagtttc gtcattcatc                                                 20 

 
           
             1219  
             20  
             DNA  
             Homo sapiens  
           
            1219 

tacattgccc atgtaattaa                                                 20 

 
           
             1220  
             20  
             DNA  
             Homo sapiens  
           
            1220 

atatagtttc gtcattcatc                                                 20 

 
           
             1221  
             20  
             DNA  
             Homo sapiens  
           
            1221 

tacattgccc atgtaattaa                                                 20 

 
           
             1222  
             20  
             DNA  
             Homo sapiens  
           
            1222 

agatagtttc gtcattcatc                                                 20 

 
           
             1223  
             20  
             DNA  
             Homo sapiens  
           
            1223 

agatagtttc ctcattcatc                                                 20 

 
           
             1224  
             20  
             DNA  
             Homo sapiens  
           
            1224 

agatagtttc gccattcatc                                                 20 

 
           
             1225  
             20  
             DNA  
             Homo sapiens  
           
            1225 

agatagtttc gtcattcatc                                                 20 

 
           
             1226  
             21  
             DNA  
             Homo sapiens  
           
            1226 

ctcatcatac ctcaaaagcc a                                               21 

 
           
             1227  
             21  
             DNA  
             Homo sapiens  
           
            1227 

tcatcatacc ccaaaagcca a                                               21 

 
           
             1228  
             21  
             DNA  
             Homo sapiens  
           
            1228 

catcatacct caaaagccaa c                                               21 

 
           
             1229  
             21  
             DNA  
             Homo sapiens  
           
            1229 

atcatacctc caaagccaac t                                               21 

 
           
             1230  
             21  
             DNA  
             Homo sapiens  
           
            1230 

tcatacctca caagccaact a                                               21 

 
           
             1231  
             21  
             DNA  
             Homo sapiens  
           
            1231 

catacctcaa cagccaacta a                                               21 

 
           
             1232  
             21  
             DNA  
             Homo sapiens  
           
            1232 

atacctcaaa cgccaactaa c                                               21 

 
           
             1233  
             21  
             DNA  
             Homo sapiens  
           
            1233 

tacctcaaaa cccaactaac c                                               21 

 
           
             1234  
             21  
             DNA  
             Homo sapiens  
           
            1234 

acctcaaaag ccaactaacc a                                               21 

 
           
             1235  
             21  
             DNA  
             Homo sapiens  
           
            1235 

cctcaaaagc caactaacca a                                               21 

 
           
             1236  
             21  
             DNA  
             Homo sapiens  
           
            1236 

ctcaaaagcc cactaaccaa c                                               21 

 
           
             1237  
             21  
             DNA  
             Homo sapiens  
           
            1237 

tcaaaagcca cctaaccaac c                                               21 

 
           
             1238  
             21  
             DNA  
             Homo sapiens  
           
            1238 

caaaagccaa ctaaccaacc a                                               21 

 
           
             1239  
             21  
             DNA  
             Homo sapiens  
           
            1239 

aaaagccaac caaccaacca a                                               21 

 
           
             1240  
             21  
             DNA  
             Homo sapiens  
           
            1240 

aaagccaact caccaaccaa t                                               21 

 
           
             1241  
             20  
             DNA  
             Homo sapiens  
           
            1241 

atatagtttc gtcattcatc                                                 20 

 
           
             1242  
             20  
             DNA  
             Homo sapiens  
           
            1242 

tacattgccc atgtaattaa                                                 20 

 
           
             1243  
             20  
             DNA  
             Homo sapiens  
           
            1243 

atatagtttc gtcattcatc                                                 20 

 
           
             1244  
             20  
             DNA  
             Homo sapiens  
           
            1244 

tacattgccc atgtaattaa                                                 20 

 
           
             1245  
             20  
             DNA  
             Homo sapiens  
           
            1245 

agatagtttc gtcattcatc                                                 20 

 
           
             1246  
             20  
             DNA  
             Homo sapiens  
           
            1246 

agatagtttc ctcattcatc                                                 20 

 
           
             1247  
             20  
             DNA  
             Homo sapiens  
           
            1247 

agatagtttc gccattcatc                                                 20 

 
           
             1248  
             20  
             DNA  
             Homo sapiens  
           
            1248 

agatagtttc gtcattcatc                                                 20 

 
           
             1249  
             21  
             DNA  
             Homo sapiens  
           
            1249 

cctcatcata actcaaaagc c                                               21 

 
           
             1250  
             20  
             DNA  
             Homo sapiens  
           
            1250 

tacattgccc atgtaattaa                                                 20 

 
           
             1251  
             20  
             DNA  
             Homo sapiens  
           
            1251 

atatagtttc gtcattcatc                                                 20 

 
           
             1252  
             20  
             DNA  
             Homo sapiens  
           
            1252 

tacattgccc atgtaattaa                                                 20 

 
           
             1253  
             20  
             DNA  
             Homo sapiens  
           
            1253 

atatagtttc gtcattcatc                                                 20 

 
           
             1254  
             20  
             DNA  
             Homo sapiens  
           
            1254 

agatagttta gtcattcatc                                                 20 

 
           
             1255  
             20  
             DNA  
             Homo sapiens  
           
            1255 

agatagtttc atcattcatc                                                 20 

 
           
             1256  
             20  
             DNA  
             Homo sapiens  
           
            1256 

agatagtttc gacattcatc                                                 20 

 
           
             1257  
             20  
             DNA  
             Homo sapiens  
           
            1257 

agatagtttc gtaattcatc                                                 20 

 
           
             1258  
             21  
             DNA  
             Homo sapiens  
           
            1258 

ctcatcatac atcaaaagcc a                                               21 

 
           
             1259  
             21  
             DNA  
             Homo sapiens  
           
            1259 

tcatcatacc acaaaagcca a                                               21 

 
           
             1260  
             21  
             DNA  
             Homo sapiens  
           
            1260 

catcatacct aaaaagccaa c                                               21 

 
           
             1261  
             21  
             DNA  
             Homo sapiens  
           
            1261 

atcatacctc aaaagccaac t                                               21 

 
           
             1262  
             21  
             DNA  
             Homo sapiens  
           
            1262 

tcatacctca aaagccaact a                                               21 

 
           
             1263  
             21  
             DNA  
             Homo sapiens  
           
            1263 

catacctcaa aagccaacta a                                               21 

 
           
             1264  
             21  
             DNA  
             Homo sapiens  
           
            1264 

atacctcaaa agccaactaa c                                               21 

 
           
             1265  
             21  
             DNA  
             Homo sapiens  
           
            1265 

tacctcaaaa accaactaac c                                               21 

 
           
             1266  
             21  
             DNA  
             Homo sapiens  
           
            1266 

acctcaaaag acaactaacc a                                               21 

 
           
             1267  
             21  
             DNA  
             Homo sapiens  
           
            1267 

cctcaaaagc aaactaacca a                                               21 

 
           
             1268  
             21  
             DNA  
             Homo sapiens  
           
            1268 

ctcaaaagcc aactaaccaa c                                               21 

 
           
             1269  
             21  
             DNA  
             Homo sapiens  
           
            1269 

tcaaaagcca actaaccaac c                                               21 

 
           
             1270  
             21  
             DNA  
             Homo sapiens  
           
            1270 

caaaagccaa ataaccaacc a                                               21 

 
           
             1271  
             21  
             DNA  
             Homo sapiens  
           
            1271 

aaaagccaac aaaccaacca a                                               21 

 
           
             1272  
             21  
             DNA  
             Homo sapiens  
           
            1272 

aaagccaact aaccaaccaa t                                               21 

 
           
             1273  
             20  
             DNA  
             Homo sapiens  
           
            1273 

tacattgccc atgtaattaa                                                 20 

 
           
             1274  
             20  
             DNA  
             Homo sapiens  
           
            1274 

atatagtttc gtcattcatc                                                 20 

 
           
             1275  
             20  
             DNA  
             Homo sapiens  
           
            1275 

tacattgccc atgtaattaa                                                 20 

 
           
             1276  
             20  
             DNA  
             Homo sapiens  
           
            1276 

atatagtttc gtcattcatc                                                 20 

 
           
             1277  
             20  
             DNA  
             Homo sapiens  
           
            1277 

agatagttta gtcattcatc                                                 20 

 
           
             1278  
             20  
             DNA  
             Homo sapiens  
           
            1278 

agatagtttc atcattcatc                                                 20 

 
           
             1279  
             20  
             DNA  
             Homo sapiens  
           
            1279 

agatagtttc gacattcatc                                                 20 

 
           
             1280  
             20  
             DNA  
             Homo sapiens  
           
            1280 

agatagtttc gtaattcatc                                                 20 

 
           
             1281  
             39  
             DNA  
             Homo sapiens  
           
            1281 

gttttcccag tcacgacttg gttggttatt agagggtgg                            39 

 
           
             1282  
             38  
             DNA  
             Homo sapiens  
           
            1282 

aaacagctat gaccatgacc ataaccaacc aatcaacc                             38 

 
           
             1283  
             144  
             DNA  
             Homo sapiens  
           
            1283 

ctggctggtc accagagggt ggggcggacc gagtgcgctc ggcggctgcg gagaggggta     60 

gagcaggcag cgggcggcgg ggagcagcat ggagccggcg gcggggagca gcatggagcc    120 

ttcggctgac tggctggcca cggc                                           144 

 
           
             1284  
             18  
             DNA  
             Homo sapiens  
           
            1284 

ttagaggatt tgagggat                                                   18 

 
           
             1285  
             18  
             DNA  
             Homo sapiens  
           
            1285 

aaaactccat actactcc                                                   18 

 
           
             1286  
             60  
             DNA  
             Homo sapiens  
           
            1286 

cttggctgtc ccagaatgca agaagcccag acggaaaccg tagctgccct ggtaggtttt     60 

 
           
             1287  
             20  
             DNA  
             Homo sapiens  
           
            1287 

tatatcaaag cagtaagtag                                                 20 

 
           
             1288  
             90  
             DNA  
             Homo sapiens  
           
            1288 

ccaccctcta ataaccaacc aacccctcct ctttcttcct ccaatactaa caaaaaaacc     60 

ccctccaacc ctatccctca aatcctctaa                                      90 

 
           
             1289  
             90  
             DNA  
             Homo sapiens  
           
            1289 

gtgtgtttgg tggttgcgga gagggggaga gtaggtagtg ggtggtgggg agtagtatgg     60 

agttggtggt ggggagtagt atggagtttt                                      90 

 
           
             1290  
             100  
             DNA  
             Homo sapiens  
           
            1290 

ttagaggatt tgagggatag ggttggaggg ggtttttttg ttagtattgg aggaagaaag     60 

aggaggggtt ggttggttat tagagggtgg ggtggattgt                          100 

 
           
             1291  
             100  
             DNA  
             Homo sapiens  
           
            1291 

aaaactccat actactcccc accaccaact ccatactact ccccaccacc cactacctac     60 

tctccccctc tccgcaacca ccaaacacac acaatccacc                          100

Technology Classification (CPC): 2