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0 | Bifidobacterium longum | ulcerative colitis (UC) | The symbiotic therapy involving Bifidobacterium longum and Synergy 1 has been shown to have benefits to both Crohn?s disease (CD) and ulcerative colitis (UC) patients. | negative | What is the relationship between Bifidobacterium longum and ulcerative colitis (UC)? |
1 | Parabacteroides | obese | Previous studies have demonstrated that decreased relative abundance of Akkermansia and increased relative abundance of Bacteroides, Ruminococcus and Parabacteroides in the gut microbiome can improve glucose homeostasis in obese mice and provide a catabolic pathway through a novel mannosylglucose phosphorylase, suggesting that Akkermansia, Bacteroides, Ruminococcus and Parabacteroides may serve an important function in the mechanism of glycometabolism (16?19). | negative | What is the relationship between Parabacteroides and obese? |
2 | L. rhamnosus | psychiatric disorders | Therefore, L. rhamnosus may have beneficial psychological effects in patients suffering from psychiatric disorders with these symptoms, including those with OCD, anxiety or AN. | negative | What is the relationship between L. rhamnosus and psychiatric disorders? |
3 | Clostridium septicum (C. septicum) | colorectal cancer | The pathogens that appear to be primarily involved in the pathogenesis of colorectal cancer are Streptococcus bovis (S. bovis), Hp, Bacteroides fragilis (B. fragilis), Enterococcus faecalis (E. faecalis), Clostridium septicum (C. septicum), Fusobacterium spp. | positive | What is the relationship between Clostridium septicum (C. septicum) and colorectal cancer? |
4 | Sutterella | autism | Gut microbiota in patients with autism is often different with increased levels of Bacteroides phylum, Sutterella species and toxin-producing Clostridium histolyticum, but with reduced amounts of Firmicutes, Veilonellaseae, Prevotella and Coprococcus species bacteria. | positive | What is the relationship between Sutterella and autism? |
5 | Eubacterium ventriosum | obesity | Coprococcus catus, Blautia hydrogenotrophic, Ruminococcus bromii, Ruminococcus obeum, and Eubacterium ventriosum were significantly correlated with obesity in Japanese people [60,61,62], whereas the presence of Bacteroides thetaiotaomicron, Bacteroides faecichinchillae, Flavonifractor plautii, Blautiawexlerae, and Clostridium bolteae was associated with lean people [63]. | relate | What is the relationship between Eubacterium ventriosum and obesity? |
6 | Proteus mirabilis | IPF | Specifically, the authors observed pathogen growth (e.g., Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae, Moraxella catarrhalis, Pseudomonas aeruginosa and Proteus mirabilis) in 8/22 (36%) IPF patients, suggesting that occult bacterial infection may contribute to the development of IPF. | positive | What is the relationship between Proteus mirabilis and IPF? |
7 | Streptococcus | urinary tract infection (UTI) | Among the 25 increased genera, many anaerobic bacteria, such as Gardnerella, Prevotella, and Atopobium, are the main pathogens for bacterial vaginosis (BV), while the abundance of many aerobic bacteria, such as Escherichia, Enterococcus, Streptococcus, and Corynebacterium, are closely related to the risk of aerobic vaginitis (AV) and urinary tract infection (UTI). | relate | What is the relationship between Streptococcus and urinary tract infection (UTI)? |
8 | Lactobacillus acidophilus | colitis | Other surface-associated protein are more related in regulating inflammatory responses such as Lactobacillus acidophilus S-layer A, which has been shown to protect mouse against experimentally induced colitis through a specific interaction with SIGNR3 (Lightfoot et al., 2015). | negative | What is the relationship between Lactobacillus acidophilus and colitis? |
9 | Clostridium | ASD | Conclusions The results of the present systematic review demonstrate an association between Clostridium bacteria colonization of the intestinal tract and ASD. | relate | What is the relationship between Clostridium and ASD? |
10 | Bacteroides ovatus | chronic pancreatitis | [8] conducted a comprehensive analysis and comparison of gut microbiota between patients with type 1 autoimmune pancreatitis and chronic pancreatitis, and found that Bacteroides ovatus, Streptococcus australis, Streptococcus gordonii, Clostridium lactatifermentans, and Clostridium lavalense were more abundant in chronic pancreatitis patients. | positive | What is the relationship between Bacteroides ovatus and chronic pancreatitis? |
11 | Staphylococcus aureus | CF | Cystic fibrosis (CF) lung-transplant recipients are at particularly high risk of infection due to chronic pre-transplant colonization with microorganisms including Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa, the latter being the most frequent pathogen in adult CF-patients (Cystic Fibrosis Foundation, 2011). | positive | What is the relationship between Staphylococcus aureus and CF? |
12 | Dysgonomonas wimpennyi | periodontitis | In periodontitis patients, four genera (Dysgonomonas, Paenibacillus, Mycoplasma, and Campylobacter) and five species (Porphyromonas endodontalis, Dysgonomonas wimpennyi, P. canis, Campylobacter gracilis, and Leptotrichia buccalis) were higher, and only one species (P. melaninogenica) was lower in the C+P+ group compared to the C?P+ group (Figures 3 and 4). | positive | What is the relationship between Dysgonomonas wimpennyi and periodontitis? |
13 | Tannerella forsythia (Tf) | periodontal diseases | Four common periodontopathogens, Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi) and Tannerella forsythia (Tf), which are highly related to periodontal diseases and were mostly reported in the included studies, were selected for qualitative and quantitative analysis. | relate | What is the relationship between Tannerella forsythia (Tf) and periodontal diseases? |
14 | Prevotella | cholangitis | It was also observed that oral cavity and respiratory tract microorganisms were more prevalent than intestinal microorganisms in the microbiota of the common bile duct of gallstone disease patients or that the genera Prevotella, Streptococcus, Veillonella, Fusobacterium, and Haemophilus are prevalent in the bile microbial communities of the bile duct of primary sclerosing cholangitis patients, among other findings. | relate | What is the relationship between Prevotella and cholangitis? |
15 | Human papilloma virus (HPV) | cervical cancers | Human papilloma virus (HPV) causes cervical cancers (Hausen, 1996) whereas Helicobacter pylori induce gastric cancers and Mucosa-associated lymphoid tissue (MALT) lymphoma (Cover and Blaser, 2009). | positive | What is the relationship between Human papilloma virus (HPV) and cervical cancers? |
16 | Streptococcus agalactiae | sepsis | Streptococcus agalactiae, or Group B streptococcus (GBS) is an important pathogen causing sepsis and meningitis in newborns and mastitis in bovine (Edwards and Baker, 2005; Tazi et al., 2011; Edmond et al., 2012; Lamagni et al., 2013). | positive | What is the relationship between Streptococcus agalactiae and sepsis? |
17 | AIEC | chronic inflammation | To this aim, we have carried out experiments testing the ability of 6-MP to inhibit epithelial cell adhesion and invasion by the AIEC strain LF82, important pathogenic processes directly involved in the onset of chronic inflammation in CD (Eaves-Pyles et al., 2008). | positive | What is the relationship between AIEC and chronic inflammation? |
18 | Escherichia | esophageal abnormalities | [52] 2014 Thirteen patients with esophagitis, six patients with BE, fifteen normal controls 16S rRNA The Enterobacteriaceae family (mainly the genus Escherichia) is associated with esophageal abnormalities, such as esophagitis and BE. | relate | What is the relationship between Escherichia and esophageal abnormalities? |
19 | Akkermansia muciniphila | BC | The abundance of Akkermansia muciniphila, as a key player of propionate production, is associated with the richness of the gut microbiota in patients with BC (44). | relate | What is the relationship between Akkermansia muciniphila and BC? |
20 | Helicobacter pylori | tumor | Intestinal bacteria with pro-carcinogenic properties, such as Helicobacter pylori, Escherichia coli, Streptococcus gallolyticus (formerly bovis), Fusobacterium spp., and Bacteroides fragiles have been identified in fecal or tumor samples from human patients with adenoma and carcinoma [11?15]. | positive | What is the relationship between Helicobacter pylori and tumor? |
21 | Porphyromonas gingivalis (Pg) | periodontal diseases | Four common periodontopathogens, Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi) and Tannerella forsythia (Tf), which are highly related to periodontal diseases and were mostly reported in the included studies, were selected for qualitative and quantitative analysis. | relate | What is the relationship between Porphyromonas gingivalis (Pg) and periodontal diseases? |
22 | Streptococcus | colon cancer | Although specific bacterial species have yet to be proven to be the cause of colon cancer, the minor gut colonizer Streptococcus bovis has been implicated in some clinical studies. | relate | What is the relationship between Streptococcus and colon cancer? |
23 | Fusobacterium | gastric cancer | Our results showed an underrepresentation of H. pylori among the gastric microbiota of the patients with gastric cancer, while Fusobacterium and Clostridium were frequently enriched. | positive | What is the relationship between Fusobacterium and gastric cancer? |
24 | Streptococcus | tumours | In contrast to the study by Pushalkar et al., the abundance of genera Streptococcus and Rothia was significantly lower in the tumour samples compared with contra-lateral normal as well as to the pre-cancer samples; instead, the tumours were associated with significantly higher proportions of the genus Fusobacterium. | negative | What is the relationship between Streptococcus and tumours? |
25 | Ralstonia | asthma | In addition, Ralstonia is more abundant in patients with asthma than in those with non-asthmatic chronic rhinosinusitis (45) and is associated with the inflammatory response in Parkinson?s disease (46) and the mucosal Th2 response in food allergy (47). | positive | What is the relationship between Ralstonia and asthma? |
26 | Lactobacillus johnsonii | CRC | Administration of Lactobacillus johnsonii modulated immune responses and decreased the risk of pathogen colonization in CRC patients. | negative | What is the relationship between Lactobacillus johnsonii and CRC? |
27 | Enterococcus | lung cancer | Interestingly, Enterococcus has been related to several cancers, such as colon cancer, and lung cancer. | relate | What is the relationship between Enterococcus and lung cancer? |
28 | HP | gastric carcinogenesis | Previous studies have found that the increased abundance of HP in the tumoral sites is classically believed to contribute to GC tumorigenesis, and mass eradication of HP significantly decreases the risk of developing cancer in infected individuals without pre-malignant lesions (88?90), reinforcing the theory that HP influences early stages in gastric carcinogenesis. | positive | What is the relationship between HP and gastric carcinogenesis? |
29 | HP | IBD | Microbes from the genera Roseburia and Enterobacter were related to Helicobacter pylori (HP) in gastritis and Clostridioides difficile infection (CDI) in IBD. | relate | What is the relationship between HP and IBD? |
30 | Fusobacterium | colorectal cancer (CRC) | Recent studies have reported a positive correlation between Fusobacterium abundance and IBD in the host, and a strong association between Fusobacterium and colorectal cancer (CRC). | relate | What is the relationship between Fusobacterium and colorectal cancer (CRC)? |
31 | Escherichia | CRC | Likewise, the population of some enteropathogenic bacteria, such as those from the Escherichia and Shigella genera and the Enterococcaceae family, was shown to be larger in the intestines of CRC patients [19,23,32,33]. | positive | What is the relationship between Escherichia and CRC? |
32 | Lactobacillus helveticus | cancer | Oral supplementation with Lactobacillus helveticus-fermented milk in this model has resulted in increased cancer cell apoptosis and reduced production of pro-inflammatory cytokines, while treatment with Lactobacillus acidophilus has been associated with tumor growth retardation and reduced systemic inflammation [82,83]. | negative | What is the relationship between Lactobacillus helveticus and cancer? |
33 | Akkermansia muciniphila | obesity | One such species is Akkermansia muciniphila, which is currently being assessed as a treatment for obesity.74 Of note, intestinal helminths, such as N. brasiliensis, H. polygyrus or Trichuris muris, are directly at the intersection of type 2 immunity, microbiota and metabolism. | negative | What is the relationship between Akkermansia muciniphila and obesity? |
34 | Enterobacter cloacae | obesity | Moreover, an opportunistic pathogen, Enterobacter cloacae B29, isolated from a diabetic obese human?s gut, can induce obesity and insulin resistance in germfree mice (9). | positive | What is the relationship between Enterobacter cloacae and obesity? |
35 | Hp | MALT | Introduction Helicobacter pylori (Hp) infections are related to the onset of various gut diseases, such as gastritis, gastric cancer, and mucosa-associated lymphoid tissue lymphoma (MALT) [1,2,3]. | relate | What is the relationship between Hp and MALT? |
36 | Ruminococcus | irritable bowel syndrome | Moreover, a recent study reported that irritable bowel syndrome (IBS) subjects had a different pattern of enterotypes, where the Ruminococcus-rich enterotype was highly dominant, whereas autistic samples contained evenly distributed Ruminococcus-rich and Bacteroides-rich enterotypes (Figure 4B). | positive | What is the relationship between Ruminococcus and irritable bowel syndrome? |
37 | Streptococcus | gastric cancer | Moreover, apart from H. Pylori, reduction of different other bacteria like Streptococcus sinensis, Acinetobacter baumannii, Prevotella pallens, Klebsiella pneumonia, Lactobacillus colihominis, and Lachnospiraceae are also responsible for gastric cancer in the human [91][92][93]. | relate | What is the relationship between Streptococcus and gastric cancer? |
38 | Porphyromonas | periodontitis | For instance, saccharolytic (sugar metabolizing) bacteria, such as Streptococcus and Lactobacillus, have been associated with dental caries, while proteolytic (protein metabolizing) bacteria, such as Prevotella and Porphyromonas, have been associated with periodontitis and halitosis (40). | relate | What is the relationship between Porphyromonas and periodontitis? |
39 | Fusobacterium nucleatum | oral cancer | Of all oral bacteria, Porphyromonas gingivalis and Fusobacterium nucleatum might possess the greatest potential to be correlated with oral cancer, as both have been implicated in pancreatic and colorectal cancers. | relate | What is the relationship between Fusobacterium nucleatum and oral cancer? |
40 | Streptococcus | colorectal cancer | In addition, many other species of Clostridium and Streptococcus, such as Clostridium difficile (Zheng et al., 2017), Streptococcus gallolyticus (Andres-Franch et al., 2017), and Streptococcus infantarius (Kaindi et al., 2018), were reported to be associated with colorectal cancer. | relate | What is the relationship between Streptococcus and colorectal cancer? |
41 | Bifidobacterium | Parkinson's Disease | A 2-year follow-up study by the same group recently revealed that lower counts of Bifidobacterium and Bacteroides fragilis in year 0 were associated with worsening on the Unified Parkinson's Disease Rating Scale over the next 2 years, suggesting that changes in the intestinal microbiota are associated with the progression of PD (Minato et al., 2017). | relate | What is the relationship between Bifidobacterium and Parkinson's Disease ? |
42 | Porphyromonas gingivalis | cardiovascular disease | Among the periodontal bacteria, Streptococcus sanguinis and Porphyromonas gingivalis are commonly involved in cardiovascular disease [37]. | relate | What is the relationship between Porphyromonas gingivalis and cardiovascular disease? |
43 | Ruminococcus | AD | Several bacteria taxa in AD patients were different from those in controls at taxonomic levels, such as Bacteroides Actinobacteria, Ruminococcus, Lachnospiraceae, and Selenomonadales, from 43 AD patients using 16S ribosomal RNA sequencing [112]. | relate | What is the relationship between Ruminococcus and AD? |
44 | Clostridium | CF | It was noted that the levels of these pathways in Bacteroides, Lachnospiracheae, Clostridium and Enterococcus were significantly increased in the CF patients compared to the controls, which could contribute to the altered starch catabolic pathways. | positive | What is the relationship between Clostridium and CF? |
45 | Bifidobacterium bifidum | systemic lupus erythematosus | No previous association of Blautia coccoides (which was depleted in our na?ve group) with RA was reported; nonetheless, it was shown that enriching the gut microbiota of systemic lupus erythematosus patients with Blautia coccoides, together with Ruminococcus obeum and Bifidobacterium bifidum, improved the inflammatory status by inducing the production of the immunosuppressive regulatory T cells (Tregs) [31]. | relate | What is the relationship between Bifidobacterium bifidum and systemic lupus erythematosus? |
46 | Faecalibacterium prausnitzii | ESRD | Based on the sequencing data, Roseburia spp., Faecalibacterium prausnitzii and Prevotella which are typical butyrate producing bacteria were decreased in ESRD patients, so we chose it. | negative | What is the relationship between Faecalibacterium prausnitzii and ESRD? |
47 | Helicobacter pylori | gastric mucosal biopsies | (2015) used MegaBlast to remap the unmapped reads of whole genome sequences of 27 gastric mucosal biopsies to microbial reference genomes, and they verified a close association between Helicobacter pylori and gastric tumors. | relate | What is the relationship between Helicobacter pylori and gastric mucosal biopsies? |
48 | Porphyromonas gingivalis | COPD | In a previous study, some specific bacteria including Klebsiella pneumonia, Pseudomonas aeruginosa, Streptococcus pneumoniae, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia were more abundant in both tracheal aspirate and periodontal pockets in severe acute exacerbations of COPD patients, suggesting particular bacteria were related to acute exacerbations of COPD. | positive | What is the relationship between Porphyromonas gingivalis and COPD? |
49 | Group B streptococcus | sepsis | Streptococcus agalactiae, or Group B streptococcus (GBS) is an important pathogen causing sepsis and meningitis in newborns and mastitis in bovine (Edwards and Baker, 2005; Tazi et al., 2011; Edmond et al., 2012; Lamagni et al., 2013). | positive | What is the relationship between Group B streptococcus and sepsis? |
50 | Treponema denticola | COPD | In a previous study, some specific bacteria including Klebsiella pneumonia, Pseudomonas aeruginosa, Streptococcus pneumoniae, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia were more abundant in both tracheal aspirate and periodontal pockets in severe acute exacerbations of COPD patients, suggesting particular bacteria were related to acute exacerbations of COPD. | positive | What is the relationship between Treponema denticola and COPD? |
51 | Prevotella | gingivitis | Additionally, our data in UC and CC specimens show the presence of several orange (Prevotella, Peptostreptococcus, Eubacterium, Fusobacterium, and Campylobacter), red (Porphyromonas), purple (Veillonella), and yellow (Streptococcus) complex putative oral pathogens known to cause gingivitis and periodontitis among IBD patients (Tables 1, 3). | relate | What is the relationship between Prevotella and gingivitis? |
52 | Clostridium difficile | FMT | For example, FMT is highly effective for recurrent Clostridium difficile infection [127], to the point that it has been approved by the United States Federal Drug Administration (FDA) [128]. | negative | What is the relationship between Clostridium difficile and FMT? |
53 | Pg | chronic arthritis | Overall, these date suggest that invaded Pg in arthritic joints may induce synovial inflammation and promote chronic arthritis. | positive | What is the relationship between Pg and chronic arthritis? |
54 | Helicobacter pylori | cancer | While the link between viruses and cancer has been extensively researched, it is notable that Helicobacter pylori has remained the best-studied and, for nearly two decades, the sole bacterial pathogen systematically linked with any type of cancer in clinical practice. | relate | What is the relationship between Helicobacter pylori and cancer? |
55 | Phascolarctobacterium | HCC | The sequencing of 16S bacterial RNA showed in the stool of HCC patients increased abundance of Bacteroides, Ruminococcus, Enterococcus, Phascolarctobacterium, and Oscillospira and decreased abundance of Bifidobacteria and Blautia as compared with liver cirrhosis without HCC. | positive | What is the relationship between Phascolarctobacterium and HCC? |
56 | Treponema denticola | atherosclerotic plaque lesions | In fact, infection of ApoE null hyperlipidemic mice with four established periodontal pathogens?Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Fusobacterium nucleatum, led to elevations of serum inflammatory markers and progression of atherosclerotic plaque lesions [16]. | positive | What is the relationship between Treponema denticola and atherosclerotic plaque lesions? |
57 | Faecalibacterium prausnitzii | CD | The gut microbiome is a key factor in the pathogenesis of IBD and a dysbiosis, mainly characterized by downregulation of butyrate-producing species like Faecalibacterium prausnitzii, belonging to the Ruminococcaceae family, has consistently been reported in patients with IBD and especially in patients with CD (11?13). | negative | What is the relationship between Faecalibacterium prausnitzii and CD? |
58 | Streptococcus | atherosclerosis | Microbiota and their many metabolic products may largely account for the rest.80 For example, DNA of oral microbiota Veillonella and Streptococcus was found in plaques of individuals with atherosclerosis and their abundance correlated with the abundance of these species in the oral cavity.53 As for gut microbiota, Karlsson et?al. | relate | What is the relationship between Streptococcus and atherosclerosis? |
59 | Enterococcus | AP | In the context of pancreatic disease, a multi-hospital prospective clinical study showed that the intestinal population of Enterococcus is higher and more positively correlated with the serum levels of IL-6 in severe AP than in mild AP (66), suggesting that the increase in Enterococcus contributes to the severity of this disease. | positive | What is the relationship between Enterococcus and AP? |
60 | Streptococcus | liver cirrhosis | Intestinal dysbiosis has already been described in patients with liver cirrhosis, with an increase in Veillonella, Streptococcus, Prevotella, Lactobacillus and Fusobacterium, among others. | positive | What is the relationship between Streptococcus and liver cirrhosis? |
61 | Butyricicoccus pullicaecorum | bacterial infection | In animal models, administration of B. fragilis, Butyricicoccus pullicaecorum or Roseburia hominis exerted effects to increase butyrate production, inhibit bacterial infection and reduce inflammation (848586). | negative | What is the relationship between Butyricicoccus pullicaecorum and bacterial infection? |
62 | Desulfovibrio | ASD | Specifically, a lower ratio of Bacteroidetes-to-Firmicutes and a higher abundance of Clostridium and Desulfovibrio were positively associated with severity of ASD symptoms (Tomova et al., 2015). | positive | What is the relationship between Desulfovibrio and ASD? |
63 | Akkermansia muciniphila | kidney cancer | They reported that higher levels of Akkermansia muciniphila, a gram-negative anaerobe, were associated with good outcomes in patients with lung or kidney cancer. | negative | What is the relationship between Akkermansia muciniphila and kidney cancer? |
64 | S. salivarius probiotic strain K12 | candidiasis | The S. salivarius probiotic strain K12 inhibits adherence and filamentation of C. albicans, and in a murine model of infection candidiasis protected mice from severe candidiasis [82]. | negative | What is the relationship between S. salivarius probiotic strain K12 and candidiasis? |
65 | Lactobacillus fermentum | inflammation | These findings suggest that combined Lactobacillus fermentum and Pediococcus acidilactici supplementation of diets improved growth performance, alleviated inflammation and regulated gut health by promoting beneficial bacteria, inhibiting pathogens, and promoting the production of SCFAs in weaned pigs. | negative | What is the relationship between Lactobacillus fermentum and inflammation? |
66 | Faecalibacterium prausnitzii | AD | [8,9] Recent studies have indicated that dysbiosis in Faecalibacterium prausnitzii and dysregulation of gut epithelial inflammation might affect the chronic progression of AD by resulting in impairment of the gut epithelial barrier. | positive | What is the relationship between Faecalibacterium prausnitzii and AD? |
67 | streptococcus | chorioamnionitis | In Malawi approximately 21% of pregnant women carry group B streptococcus (GBS) [43] and has also been found to involved with placental infection and chorioamnionitis. | relate | What is the relationship between streptococcus and chorioamnionitis? |
68 | Bacteroides fragilis | CRC | Several specific microbes, including Streptococcus gallolyticus, Enterococcus faecalis, colibactin-producing Escherichia coli, enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum, are involved in development of CRC through modulation of the tumor immune environment and promotion of DNA damage [6]. | relate | What is the relationship between Bacteroides fragilis and CRC? |
69 | Fusobacterium | CRC | The abundance of several microbes, such as Streptococcus gallolyticus, Fusobacterium, B. fragilis, Escherichia Shigella, Peptostreptococcus ten were observed to be enriched in CRC patients versus control groups, while genera such as Bacteroides, Roseburia [164] and Pseudomonas [167] were significantly depleted in CRC patients. | positive | What is the relationship between Fusobacterium and CRC? |
70 | Clostridium perfringens | gastrointestinal infections | One such example is Clostridium perfringens, which is a member of the gut microbiota as well as an opportunistic pathogen frequently associated with gastrointestinal infections [11, 12]. | relate | What is the relationship between Clostridium perfringens and gastrointestinal infections? |
71 | Fusobacterium | colorectal carcinoma | Recently, Kostic et al.reported the association of Fusobacterium with colorectal carcinoma. | relate | What is the relationship between Fusobacterium and colorectal carcinoma? |
72 | Lactococcus plantarum | colitis | In similar studies, engineered bacteria, such as Lactobacillus casei, Lactococcus plantarum, and Streptococcus gordonii, have been used to deliver various molecules to treat colitis in animal models of IBD. | negative | What is the relationship between Lactococcus plantarum and colitis? |
73 | Haemophilus influenzae | paediatric respiratory infection | For example, in the context of paediatric respiratory infection, Haemophilus influenzae is considered an important pathogen, whereas Haemophilus haemolyticus is considered commensal. | positive | What is the relationship between Haemophilus influenzae and paediatric respiratory infection? |
74 | Escherichia coli | acute meningitis | Streptococcus pneumoniae, Streptococcus agalactiae (group B Streptococcus), Neisseria meningitis, Haemophilus influenzae and Escherichia coli (particularly the K1 serotype) are currently the most common bacterial pathogens causing acute meningitis in the United States. | positive | What is the relationship between Escherichia coli and acute meningitis? |
75 | Escherichia | Crohn?s disease | For example, 2 of the microorganisms on our panel, Escherichia-Shigella and Ruminococcus, are associated with Crohn?s disease, while 5 other organisms, Akkermansia muciniphila, Bifidobacterium, Dialister invisus, Odoribacter and Roseburia, are inversely associated with Crohn?s disease (Fig 5, S2 Table). | relate | What is the relationship between Escherichia and Crohn?s disease? |
76 | Porphyromonas gingivalis | pancreatic cancer | Another prospective cohort study analyzed 361 patients with incident pancreatic cancer and 371 matched controls and revealed that Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were associated with a higher risk of pancreatic cancer (odds ratio: 2.20, 95% confidence interval: 1.16 to 4.18). | relate | What is the relationship between Porphyromonas gingivalis and pancreatic cancer? |
77 | Eubacterium | periodontitis | Additionally, our data in UC and CC specimens show the presence of several orange (Prevotella, Peptostreptococcus, Eubacterium, Fusobacterium, and Campylobacter), red (Porphyromonas), purple (Veillonella), and yellow (Streptococcus) complex putative oral pathogens known to cause gingivitis and periodontitis among IBD patients (Tables 1, 3). | relate | What is the relationship between Eubacterium and periodontitis? |
78 | Escherichia | ID | Given that the observed prevalence of Bifidobacterium and Lactobacillus were higher in feces of ID pigs, the increase in the relative abundance of Escherichia/Shigella is even more surprising. | positive | What is the relationship between Escherichia and ID? |
79 | Granulicatella adiacens | pancreatic cancer | B. fragilis is known to induce signal transducer and activator of transcription 3 and Th17-dependent pathway in colitis-associated CRC (see Supplementary Data 8 for detection of bft genes from enterotoxigenic B. fragilis)37 whereas the abundance of Granulicatella adiacens in saliva is associated with chronic pancreatitis and pancreatic cancer. | relate | What is the relationship between Granulicatella adiacens and pancreatic cancer? |
80 | Prevotella intermedia | GI cancer | Periodontal disease-associated species, Porphyromonas gingivalis, Tannerella forsythia and Prevotella intermedia, were correlated with a risk of GI cancer regardless of cancer type. | relate | What is the relationship between Prevotella intermedia and GI cancer? |
81 | Streptococcus gordonii | colitis | In similar studies, engineered bacteria, such as Lactobacillus casei, Lactococcus plantarum, and Streptococcus gordonii, have been used to deliver various molecules to treat colitis in animal models of IBD. | negative | What is the relationship between Streptococcus gordonii and colitis? |
82 | Prevotella melaninogenica | periodontitis | Patients with severe periodontal disease had saliva with significantly higher levels of Prevotella melaninogenica, Rothia mucilaginosa, and Fusobacterium, and plaque with significantly higher levels of Rothia dentocariosa, Fusobacterium, Streptococcus, and Prevotella compared to those with no or mild periodontitis (Fig?2A and B and Table?S5). | positive | What is the relationship between Prevotella melaninogenica and periodontitis? |
83 | Prevotella falsenii | colitis | Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii enhance and Alistipes finegoldii attenuates colitis in mice | positive | What is the relationship between Prevotella falsenii and colitis? |
84 | Prevotella | inflammation and non-infectious diseases of the colon | To this regard, it has been reported that an increased amount of Veillonella is associated with higher levels of gut inflammation and the development of colitis and Crohn?s disease; on the contrary, an increased the abundance of the Prevotella genus has been described as a shield against inflammation and non-infectious diseases of the colon. | negative | What is the relationship between Prevotella and inflammation and non-infectious diseases of the colon? |
85 | Bacteroides fragilis | cancer | Through epithelial injury and inflammation, chronic infections (viruses, Helicobacter pylori and other Helicobacter spp., Bacteroides fragilis, Bacteroides vulgatus, Escherichia coli, Citrobacter rodentium, Citrobacter freundii, and protozoa) are linked to carcinogenesis with approximately 18% of the worldwide cancer burden. | relate | What is the relationship between Bacteroides fragilis and cancer? |
86 | Enterococcus | opportunistic infections | However, there are also exceptions: for instance, some species of Enterococcus or Streptococcus can cause opportunistic infections in humans, whereby the intrinsic resistance of LAB to many antibiotics is an additional risk factor50,51. | positive | What is the relationship between Enterococcus and opportunistic infections? |
87 | Propionibacterium freudenreichii | colorectal cancer | It is noteworthy that a recent study has shown that metabolites of Propionibacterium freudenreichii can kill colorectal cancer cells, implicating its use as a probiotic for the prevention and treatment of early colorectal cancer (Casanova et al., 2018). | negative | What is the relationship between Propionibacterium freudenreichii and colorectal cancer? |
88 | Campylobacter jejuni | diarrhea | In 80% to 85% of cases, diarrhea is due to pathogenic bacteria [Escherichia coli (E. coli), enteropathogenic, Campylobacter jejuni, Shigella, Salmonella, Yersinia enterocolitica]. | positive | What is the relationship between Campylobacter jejuni and diarrhea? |
89 | Fusobacterium nucleatum | colon cancer | In the last two decades, significant evidence has emerged implicating bacteria in the aetiology of some cancer types such as Helicobacter pylori in gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphomas, Chlamydia trachomatis in cervical cancer, Salmonella typhi in gallbladder cancer and both Bacteroides fragilis and Fusobacterium nucleatum in colon cancer. | relate | What is the relationship between Fusobacterium nucleatum and colon cancer? |
90 | Capnocytophaga sputigena | OLP | [5] investigated microbial in OLP patients with non-erosive/asymptomatic lesions and found that bacterial counts for Capnocytophaga sputigena, Eikenella corrodens, Lactobacillus crispatus, Mobiluncus curtisii, Neisseria mucosa, Prevotella bivia, Prevotella intermedia, and S. agalactiae at the sites of OLP lesions are significantly higher when compared to the same sites in control subjects. | positive | What is the relationship between Capnocytophaga sputigena and OLP? |
91 | Campylobacter jejuni | foodborne bacterial gastroenteritis | Campylobacter jejuni is a microaerophilic Gram-negative bacterium that is the leading cause of foodborne bacterial gastroenteritis worldwide (Silva et al., 2011; Kaakoush et al., 2015). | positive | What is the relationship between Campylobacter jejuni and foodborne bacterial gastroenteritis? |
92 | Lactobacillus | experimental colitis | By using animal models of experimental colitis (20) and arthritis (21), it was shown that Gram-negative bacteria, including Escherichia, reduced inflammation, possibly through the TLR2/IL-10 axis which results in the repression of the pro-inflammatory pathway (20), whereas Gram-positive bacteria such as Lactobacillus contributed to the development of a more severe disease (21). | positive | What is the relationship between Lactobacillus and experimental colitis? |
93 | Clostridium | ulcerative colitis | Similarly, Clostridium XIVa has also been shown to be lower in ulcerative colitis patients compared with normal controls?(26). | negative | What is the relationship between Clostridium and ulcerative colitis? |
94 | Helicobacter pullorum | gastroenteritis | However, another important aspect to consider is that some specific enterohepatic Helicobacter species (i.e., Helicobacter pullorum) can be detected in the gut of healthy chickens as well as in the liver and the intestine of hens with vibrionic-like liver lesions and human patients with gastroenteritis [37]. | relate | What is the relationship between Helicobacter pullorum and gastroenteritis? |
95 | Porphyromonas gingivalis | colorectal cancers | Of all oral bacteria, Porphyromonas gingivalis and Fusobacterium nucleatum might possess the greatest potential to be correlated with oral cancer, as both have been implicated in pancreatic and colorectal cancers. | relate | What is the relationship between Porphyromonas gingivalis and colorectal cancers? |
96 | Porphyromonas gingivalis | NASH | [82] studied 150 patients with NAFLD (of those 102 with NASH) and 60 healthy controls, and found that infection with Porphyromonas gingivalis (the major cause of periodontitis) tripled the risk for NAFLD and quadrupled the risk for NASH, independent of ge and metabolic syndrome. | positive | What is the relationship between Porphyromonas gingivalis and NASH? |
97 | Pseudomonas aeruginosa | cystic fibrosis (CF) | Pseudomonas aeruginosa is considered to be the most important pathogen in cystic fibrosis (CF), with up to 60% of adult patients infected (UK CF Registry Annual Data Report 2014), and is also frequently isolated from patients with bronchiectasis. | positive | What is the relationship between Pseudomonas aeruginosa and cystic fibrosis (CF)? |
98 | Streptococcus mitis | pancreatic cancer | The association between the salivary microbiota and pancreatic cancer has been analyzed using the Human Oral Microbe Identification Microarray,45 and two out of six bacterial candidates (Neisseria elongate and Streptococcus mitis) had significantly lower levels in pancreatic cancer patients than in the control group (P<0.05). | negative | What is the relationship between Streptococcus mitis and pancreatic cancer? |
99 | Methanosphaera stadtmanae | cancer | Relatively little is known as to how these less-studied organisms influence human health, although several studies have suggested that methanogenic species of archaea, such as Methanosphaera stadtmanae, might be involved in the development of systemic diseases such as obesity (7?10), cancer (11?13), lung hyperresponsiveness (14), and inflammatory bowel disease (IBD) (15). | relate | What is the relationship between Methanosphaera stadtmanae and cancer? |
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