MSA
stringlengths 0
1.29k
| unaligned_seqs
dict |
---|---|
LLLLLEEEDEAAAAAMMMMMVVVVVEEEEDIVVVVLLLLLFFFFFRRRRRSSSASRKRRKEEDDDLLLLLKKKKKGGGGGDDDDDAAAAAEAAAAPPPPPGGGGGNNNNNLLLLLGGGGGVVVVVCNCCNMPLLPNNNNSGGGGGLILLIYYFYHEEEEEMLIVLDRKKRSSSSDFFFFFPPPPL | {
"seq0": "LEAMVEILFRSRELKGDAEPGNLGVCMNGLYEMDSFP",
"seq1": "LEAMVEVLFRSKELKGDAAPGNLGVNPNGIYELRSFP",
"seq2": "LEAMVEVLFRSRDLKGDAAPGNLGVCLNGLFEIKSFP",
"seq3": "LDAMVEVLFRARDLKGDAAPGNLGVCLNGLYEVKSFP",
"seq4": "LEAMVDVLFRSKDLKGDAAPGNLGVNPSGIHELRDFL"
} |
PPPPPSTDSSNSTSSKKKKKQQLQQSSASSDDDDDDDQDDKKKAKEQEQNIIVVFAAAAAVMLMMVVIVIASAAAGAGGGEEEEESSTSS---M----Y----R----A----S----A----W----H----T----N----Y----W----L----G----E----E----L----C----E-V-M-ML-L-LE-E-ER-R-RR-R-RA-V-AI-V-IE-E-TI-V-II-I-IV-L-VN-K-KL-M-M----A----N----L----A----HI-V-IG-G-GQ-Q-Q----L----VA-A-AC-V-CA-S-SY-H-HE-E-EY-Y-YV-I-VA-A-AL-L-LI-I-ID-D-DG-G-GR-R-RA----E----G---GL---LV---IS-T-TA-L-LL-T-MATTTTTTATALLLLLIIIIIFFFFFVVVVVKKKKKLVLLLCCCCCLCLLLSNCNCFFFFFSESESQQQRQRRPRPIMIMISSASSGGGGGLMFFF | {
"seq0": "PSNKQSDDKEIAVVAGESVLERRAIEIIVNLIGQACAYEYVALIDGRAEGLVSALATLIFVKLCLSFSQRISGL",
"seq1": "PTSKQSDDKQIAMVSAESTTLIFVKVCCNFEQRMSGM",
"seq2": "PDTKLADQKEVALIAGETMLERRVVEVILKMVGQAVSHEYIALIDGRTLTTALIFVKLCLCFSQPIAGF",
"seq3": "PSSKQSDDAQVAMVAGESMYRASAWHTNYWLGEELCETTLIFVKLCLNFERRMSGF",
"seq4": "PSSKQSDDKNFAMIAGESMLERRAITIIVKMANLAHIGQLVACSHEYVALIDGRGLITLMTALIFVKLCLCFSQPISGF"
} |
KKKKKGVGGTEEVEEGGGGGAAAAAGDGGGDTDDVLLLLLTITTIKKKKKDDDDDIVIIVCCCCCVGVVGQRQQRLVLLVTTTATASVAAGGGGGNANNPQYRQTEQEEQQQQSQLLLLLAAAAACVNRVSAQTSAAAAAQQFFQSSSSSHHHHHVVVVV--L----E----S--LLTQLWWWWW--QK- | {
"seq0": "KGEGAGDLTKDICVQLTAGNQEQLACSAQSHVLW",
"seq1": "KVEGADTLIKDVCGRVTSGAYQQLAVAAQSHVLW",
"seq2": "KGVGAGDLTKDICVQLTVGNREQLANQAFSHVLESTWQ",
"seq3": "KGEGAGDLTKDICVQLAAGNQESLARTAFSHVQWK",
"seq4": "KTEGAGVLIKDVCGRVTAGPTQQLAVSAQSHVLW"
} |
EEEEEFFFFFVAAVVPPPPPYYYYYGGGGGLIIILIIVIIQSTSSEEEEAAVASSSTTSSYFYYYEEEEDVLLVVEEEEEKKKKKSSSSSGGGGGKQQQQRKRRKFLLLLEEEEENDDDDRRHRQIVVIVLLLLLEEEEERENRRVTTTTGGGGGGGGGGWWWWWDDDDDIIVIIVILIISSNSGDDDDDKKKKKNNNDNV--VVF--FF | {
"seq0": "EFVPYGLIQEASYEVEKSGKRFENRILERVGGWDIVSDKNVF",
"seq1": "EFAPYGIISEVTFELEKSGQKLEDRVLEETGGWDIISDKN",
"seq2": "EFAPYGIVTEATYELEKSGQRLEDHVLENTGGWDVLNDKN",
"seq3": "EFVPYGIISESSYEVEKSGQRLEDRILERTGGWDIISDKDVF",
"seq4": "EFVPYGLISASSYDVEKSGQKLEDQVLERTGGWDIIGDKNVF"
} |
YMYMMQQKDQLIFLLEEEEETETNTYYYYYAAAIAH-HHHA-ASAI-ILII-IIIVIVIIKKSKRAASAA-S---RRRRRLLLLLTITITSSSTSNNNDNL-VLLA-RAAS-SRSE-KESW-MLFSRSRRVLVIIIIIIIANSGSTATSSSASASSSS-SRRRRRIIIIIVVVKVRKRRRQVQSS---H----E----Q-SSSASTTTTS | {
"seq0": "YQLETYAHAIIVKARLTSNLASEWSVIATSSRIVRQST",
"seq1": "MQIEEYAIKASRLISNRLINAASRIVKVST",
"seq2": "YKFETYAHAIIVSSRLTSNVRSKMSVISTSSRIVRQST",
"seq3": "MDLENYIHSLIIKARLITDLARELRIIGSARIKRSHEQAT",
"seq4": "MQLETYAHAIIIRARLTSNLASSFRIISSSSRIVRSSS"
} |
DDDDDVIIVIQQRQQSAASAIIIIILLFVLGGGGGYWWYW--L----K----N--VIHVIQEQQERRSRRKQHKKQQHQQNNSNNMVLMVKKKKK----V----SMMYFMIIIIILLLLLSSNSSDD-DDVIIIIMMMMMYYYYCAAAASLLMLVVAVVQRHQHHDDDDDEEDEE---V----N----G----M----K----R----F----S----P----Q----Y----I----D----G----E----T----R----N----L----N-SGSS-LLIL-VIII-GGGGGSSAS-QQQQ-RRNR- | {
"seq0": "DVQSILGYVQRKQNMKMILSDVMYALVRDESLVGSQR",
"seq1": "DIQAILGWIERQQNVKMILSDIMYALAHDEGLIGSQR",
"seq2": "DIRAIFGWLKNHQSHHSLKYILNIMYAMVQDDSIIGAQN",
"seq3": "DVQSIVGYVQRKQNMKFILSDIMYALVHDEVNGMKRFSPQYIDGETRNLNSLIGSQR",
"seq4": "DIQAILGWIERKQNVKVSMILSDIMCSVQHDEG"
} |
SSSSSLLTLLCCCCCAAAMADDDDDKKAKKGGGGGFFFYILLMLFKKEKKGGGGGLMITMHHHHHALAALTVTTV---C-FFFFFQVQQQYYYYYKKKKK-V--V-E--EDDDDDKKKKKKKQKKEEEEELLMLLRKLRRNNNNNLLLLLSSSSSKAKKKGGGGGLLLLLPPPPPHRRRRNNNNNLLLLLSASSSGVGGGFFFFF-K---IIIVI | {
"seq0": "SLCADKGFLKGLHATFQYKDKKELRNLSKGLPHNLSGFI",
"seq1": "SLCADKGFLKGMHLVFVYKVEDKKELKNLSAGLPRNLAVFKI",
"seq2": "STCADAGFMEGIHATFQYKDKQEMLNLSKGLPRNLSGFI",
"seq3": "SLCMDKGYLKGTHATCFQYKDKKELRNLSKGLPRNLSGFV",
"seq4": "SLCADKGIFKGMHLVFQYKVEDKKELRNLSKGLPRNLSGFI"
} |
AAAAASDSNSSLSMLGGGGGVVVIVDHDDDLLLLLG-G--IKIIIQ-QQGD-DDDR-RRRY-YYYSSTSSQQQQQTTPSSYYYYYSSSSSMMMMMAFAFFNNNNNFFFFFKKKKKQAQAADDDDDPPPPPYYYYYEEEEEIILIIASASKIILLLIIIIIAAAAAFFFFFIIIIIPPPPPEEEEEKRKRRCLCLLTKKKK | {
"seq0": "ASSGVDLGIQDRYSQTYSMANFKQDPYEIAIIAFIPEKCT",
"seq1": "ADLGVHLKSQTYSMFNFKADPYEISIIAFIPERLK",
"seq2": "ASSGVDLGIQDRYTQPYSMANFKQDPYELALIAFIPEKCK",
"seq3": "ANMGIDLIQDRYSQSYSMFNFKADPYEISLIAFIPERLK",
"seq4": "ASLGVDLIGDRYSQSYSMFNFKADPYEIKLIAFIPERLK"
} |
EDDDDIIIII-EE--PPPPPFFFFFKNNKKVTTTTQ--QQL--HLA--AAW--WLLLLLLIVVVFEEEEENCCKKNNNNNAAAAATTTTTRRRRRLLLLLHRRHHSSSSSVIIVVMLLMMNNNNNLIILLIAAITMLLLLNGGNGYLLYYAAAAAGGGGGAAAAAFFFFFPPVPPATTSSTSSTTDSADTVVVVVGGGGGKRRKKTSSTSMGGMMNNNNN | {
"seq0": "EIPFKVQLAWLIENNATRLHSVMNLIMNYAGAFPATDVGKTMN",
"seq1": "DIEPFNTLVECNATRLRSILNIALGLAGAFPTSSVGRSGN",
"seq2": "DIEPFNTLVECNATRLRSILNIALGLAGAFVTSAVGRSGN",
"seq3": "DIPFKTQHAWLVEKNATRLHSVMNLILNYAGAFPSTDVGKTMN",
"seq4": "DIPFKTQLALLFEKNATRLHSVMNLTLGYAGAFPSTTVGKSMN"
} |
DDDDDMVVMVLLLLLIILVIQQQQQRRRRRVVVVVCCCCCAAAAAGGGGGKKKKKLPLLLQQQQQEEEEETTKTTFFFFFGGGGGRKKRKE--E-I--I-V--V-F--F-RRRRRFFFFFKKKKKSSSSSIIIIIQQTQQTTTTTMFFMFVFLILDDDDDFLLFFSIISV | {
"seq0": "DMLIQRVCAGKLQETFGREIVFRFKSIQTMVDFS",
"seq1": "DVLIQRVCAGKPQETFGKRFKSIQTFFDLI",
"seq2": "DVLLQRVCAGKLQEKFGKRFKSITTFLDLI",
"seq3": "DMLVQRVCAGKLQETFGREIVFRFKSIQTMIDFS",
"seq4": "DVLIQRVCAGKLQETFGKRFKSIQTFLDFV"
} |
LLLLLLLLLINNNNNCLLLLEEEEESITTIEEEEELLLLLTTTTTFVVVVRRRRRMIIIIVVVVVTTATTFFFIFSSSNSQRKKRVAVIVKKKKKRRRRRSAAAANNNNNLLMLLYFFFFGGGGGKTTTTEEEGEVNNNNRGRRGTTTTTLAAIAEKKEKE----I---- | {
"seq0": "LLNCESELTFRMVTFSQVKRSNLYGKEVRTLEEI",
"seq1": "LLNLEIELTVRIVTFSRAKRANLFGTENGTAK",
"seq2": "LLNLETELTVRIVAFSKVKRANMFGTENRTAK",
"seq3": "LLNLETELTVRIVTINKIKRANLFGTGNRTIE",
"seq4": "LINLEIELTVRIVTFSRVKRANLFGTENGTAK"
} |
TIIVVDDASSFFFFFYYYYWAAAVA---Y----L-DDDDDLLILLAAAVAALLLLCCSCCKKKKKFFFFFIVILYIVPPPAAAGARRRRRPFPPPIIILKAAAAARRRRRTTLTTQQQQQGGGGGVVVVVAAAGAAAPGSIIIIVNENNNNNNHNAAAAAPIPPPIVVVVTQQRQGEEEETVVVV | {
"seq0": "TDFYADLAACKFIIARPIARTQGVAAINNAPITGT",
"seq1": "IDFYADLALCKFVVARFIARTQGVAAIENAIVQEV",
"seq2": "IAFYADIALSKFIPARPIARLQGVAPINNAPVQEV",
"seq3": "VSFYVYLDLVLCKFLPGRPLARTQGVGGINHAPVREV",
"seq4": "VSFWADLALCKFYPARPKARTQGVASVNNAPVQEV"
} |
STTTKIVIMVDNDNNPPPPPTMGTTQAAAALLLLLPPPPAVLVVVASSAADDDDDADDDD-S----L----G---LLLLLIIIILTTTTTRKRKKLLMLLEDDDDDNNNNTQQQQVVVVVDDDDDMMMMMIFFFMLIIIINNNNNSSASSGGGGGTVTVTGSGAAPPPPPTTTTQTSNNNVVVVVIIIIIAASAANENEDTTTTTEEEEE | {
"seq0": "SIDPTQLPVADALITRLEDTVDMILNSGTGPTTVIANTE",
"seq1": "TVNPMALPLSDDSLGLITKLDNQVDMFINSGVSPTSVIAETE",
"seq2": "TIDPGALPVSDDLITRMDNQVDMFINAGTGPTNVISNTE",
"seq3": "TMNPTALPVADDLITKLDNQVDMFINSGVAPTNVIAETE",
"seq4": "KVNPTALAVADDLLTKLDNQVDMMINSGTAPQNVIADTE"
} |
LLLLLGGGGGKKHKKPPPPPGGGGGLVVVVDRYNYK----T----STSSCFLILLLLLLLPPPPPILLIIFFFFFFFFVFEEEEENNNNNRQQDRPPPPPTIINTQKKKKSASSSPPPPPACCCCILLLIVIIIIITTIIGGGGGDDQDDIIIIILIILWIVVVVDDDDDLLLLLDDDDD | {
"seq0": "LGKPGLDKTSFLPIFFENRPTQSPAIVIGDILIDLD",
"seq1": "LGKPGVRTLLPLFFENQPIKAPCLITGDIIVDLD",
"seq2": "LGHPGVYSILPLFFENQPIKSPCLITGQIIVDLD",
"seq3": "LGKPGVNSLLPIFVENDPNKSPCLIIGDILVDLD",
"seq4": "LGKPGVYCLLPIFFENRPTKSPCIIIGDIWVDLD"
} |
TTTSA----L----S----L----T----Y----E----P----A----L----V----T----Y----K----N----A----A----Y----F----P----T----P----L----S----K----F----D----F----L----PFFYFHIIIVVWWWWWLLLLLIIIIIAAAPPHHHHHIIIIIGSSSASSSSSAAAAARRRRRRRRLLRVRMAQEEHHLLLLLRRRRRLLLILKRR--DEE--MMM--III--VIVVM--S--IVALMTVTTTSSSTTRRRRRWWWWWKQQAADDDDD---HHGGGGGAAAAA | {
"seq0": "TFIWLIAHIGSARRRQLRLKDMIVITSRWKDGA",
"seq1": "TFIWLIAHISSARRVELRLREMIIVVSRWQDGA",
"seq2": "TYIWLIAHISSARRRELRLREMIVSATSRWQDGA",
"seq3": "SFVWLIPHISSARLMHLRIVLTTRWADHGA",
"seq4": "ALSLTYEPALVTYKNAAYFPTPLSKFDFLPHVWLIPHIASARLAHLRLMMTTRWADHGA"
} |
VVVVVSAAYATATTTEEEEEPPPPPRRRRRVVVVVKKKKKTVTATTTNKTVVVVVAACCAGPPPPFFFFFKEEEESASRSDDDDDSVKKTEKKKKGGGGGPPPPPQKKKK-G----G----T----P---RRRRRTTTTTSNNNNLVVVLATTTVTAAAAESSSSGSSNSLLLLLTVVIVPPPPPGGAAADNDDDMMMMMGGGGFIIIIISSTSS | {
"seq0": "VSTEPRVKTTVAGFKSDSEGPQRTSLATEGLTPGDMGIS",
"seq1": "VAAEPRVKVTVAPFEADVKGPKGGTPRTNVTASSLVPGNMGIS",
"seq2": "VATEPRVKTNVCPFESDKKGPKRTNVTASSLVPADMGIT",
"seq3": "VYTEPRVKAKVCPFERDKKGPKRTNVTASNLIPADMGIS",
"seq4": "VATEPRVKTTVAPFESDTKGPKRTNLVASSLVPADMFIS"
} |
AAAAANNNNDSSSSSLLLLLLLLLLAAAAAAAEAAQELQEEEEEEC-CC-K-KK-NNNNNPPPPPEEEEEIIIIIDDDDDEQEEHQNQQQGDGGDKKKKKYFYYFDDDDDMMMMMVMVVVRQRRQLLLLIYYYFYNNNNNLLLLLEEQEEKKKKSDDDDDDDNDEGGGGGHYHHNFFFFFNNNND | {
"seq0": "ANSLLAAQECKNPEIDEQGKYDMVRLYNLEKDDGHFN",
"seq1": "ANSLLAAEENPEIDQNDKFDMMQLYNLEKDDGYFN",
"seq2": "ANSLLAELECKNPEIDEQGKYDMVRLYNLQKDNGHFN",
"seq3": "ANSLLAAQECKNPEIDEQGKYDMVRLFNLEKDDGHFN",
"seq4": "ADSLLAAEENPEIDHQDKFDMVQIYNLESDEGNFD"
} |
KRKKKNNNNNQQNQQAAAAKGGGGGLMMMMDDDDDPPPPPITTITGGGGGSSSSSEEEEENNNNNPPPPPLMMVMDDDDDAAAAAYYYYYHHHHHMPPPPPPPPPVVVVVGGGGGEDDDDCCCVCYYYYYQQQNQLLLLLEEEEETTTATLLLLLDDDED | {
"seq0": "KNQAGLDPIGSENPLDAYHMPVGECYQLETLD",
"seq1": "RNQAGMDPTGSENPMDAYHPPVGDCYQLETLD",
"seq2": "KNNAGMDPTGSENPMDAYHPPVGDCYQLETLD",
"seq3": "KNQAGMDPIGSENPVDAYHPPVGDVYNLEALE",
"seq4": "KNQKGMDPTGSENPMDAYHPPVGDCYQLETLD"
} |
LIIVITKTKTDEEEERRRRRRKRRRTPVPKYYYYYKKKKKQQKQQIIMIMQQQQQPPPPPQQQQQASAAAKEEEE-NNNN-DDDD-LLLL-RRRR-LLLL-SSAS-VVVV-DDDS-P-P--E-D--QWQW-LLLL--YFF-EDDE-LLLL-TTVN-RLKL | {
"seq0": "LTDRRTYKQIQPQAK",
"seq1": "IKERKPYKQIQPQSENDLRLSVDPEQLELTR",
"seq2": "ITERRVYKKMQPQAENDLRLSVDWLYDLTL",
"seq3": "VKERRPYKQIQPQAENDLRLAVDPDQLFDLVK",
"seq4": "ITERRKYKQMQPQAENDLRLSVSWLFELNL"
} |
EEEQEVVIIIRRRRRVVTAAAAAAALLLLLFLLLLILLLL--T-T--L-F--F-Y--Y-Y--T-VAAAAAMMLLLLLLLLLLLLLEEDDDFFFYFMKCCCCCHHHTTTTTPPPPPRRQQREEPPPPPPPPFEIIIIVIIISSSSSEEEEERRRRREEEEEKKKKKSSSSGEETRTSSTSTVVVVV | {
"seq0": "EVRVALFIAMLLEFMCTPREPFISEREKSESV",
"seq1": "EVRVALLLAMLLEFKCTPREPEVSEREKSESV",
"seq2": "EIRTALLLTLFYTALLLDFCHTPQPPIISEREKSTTV",
"seq3": "QIRAALLLALLLDYCHTPQPPIISEREKSRSV",
"seq4": "EIRAALLLTFYYVALLLDFCHTPRPPIISEREKGTTV"
} |
RRRRKSSSTSPPPPPVVAVVDDDDDGGGGGVVATVLVVIIHRPPHEEEEESSDDSAVVVVAAAAAANTTTLMLLLDEDDDHHHHHYYYYYGG-GGVV-VVQE-QKEE-VEFF-FYLL-LLKK-SKHH-HYPP-PPNN-NNIT-ALSS-QSAA-SAQE-KQ | {
"seq0": "RSPVDGVLHESAAALDHYGVQEFLKHPNISAQ",
"seq1": "RSPVDGVVRESVANMEHYGVEEFLKHPNTSAE",
"seq2": "RSPADGAVPEDVATLDHY",
"seq3": "RTPVDGTIPEDVATLDHYGVQVFLSHPNAQSK",
"seq4": "KSPVDGVIHESVATLDHYGVKEYLKYPNLSAQ"
} |
DDHHHHHHHHLLLELDEEPDQMLMMTVTSSIVIIIGGGGGFYYIIGGGGGIIIIIILLILDEEDDIIIVIITTIIPPPPPGGGGGFFFFFQRRQQKKRKKTCCATL--LLIIIIIGGGGGVVICVQRTRKLLLQLHRRHHVIIVVEDEEEYYYFFEDDDDLLLLLCRRRREEEEEHHHYHYYYYYIIIIITVVSQ | {
"seq0": "DHLDQTIGFGIIDIIPGFQKTLIGVQLHVEYELCEHYIT",
"seq1": "DHLEMVVGYGILEITPGFRKCIGVRLRIDYDLREHYIV",
"seq2": "HHLELTIGYGILEITPGFRRCIGITLRIEYDLREHYIV",
"seq3": "HHEPMSIGIGIIDVIPGFQKALIGCRQHVEFDLREYYIS",
"seq4": "HHLDMSIGIGILDIIPGFQKTLIGVKLHVEFDLREHYIQ"
} |
SSSSSRHHHHKQQQQVIIIVYYRYYLLLLFERDKEPPPPPLQLQLNGGGNFWWWWDDEDDEEEEEIIIIIRRRRRREEEELVIVIEEEEDSTTTTAAAAAKKKKKAVLVALYYYYNNKNNFFIFFLYHYYKKKKELLLLLPPRPPKKKAKTAAATVVVVV | {
"seq0": "SRKVYLEPLNFDEIRRLESAKALNFLKLPKTV",
"seq1": "SHQIYLRPQGWDEIREVETAKVYNFYKLPKAV",
"seq2": "SHQIRLDPLGWEEIREIETAKLYKIHKLRKAV",
"seq3": "SHQIYLKPQGWDEIREVETAKVYNFYKLPAAV",
"seq4": "SHQVYFEPLNWDEIREIDTAKAYNFYELPKTV"
} |
NNNQQHQHAAEEEEEQQQQQIIIIIFFFFFQIQTTVVVVVVVVIIEEEEEGGGGGLLLLLTTTTTLLLLLEEEEERRRRRAAAEETTTVVEEEEENNNDDLLLLLAAAAATTTSADDDDDDDDDDMMMMMQQQQQVAVIILVVVVMMMMMAAANTLLMTTKKKRRKKKKKQQQQQLLLFLRKKGKAAAAA--S----D----L----W----R----V----I----W----F-- | {
"seq0": "NHEQIFQVVEGLTLERATENLATDDMQVLMALKKQLRA",
"seq1": "NQEQIFIVVEGLTLERATENLATDDMQAVMALKKQLKA",
"seq2": "NHEQIFQVVEGLTLERATENLATDDMQVVMAMKKQLKASDLWRVIWF",
"seq3": "QAEQIFTVIEGLTLEREVEDLASDDMQIVMNTRKQFGA",
"seq4": "QAEQIFTVIEGLTLEREVEDLAADDMQIVMTTRKQLKA"
} |
IKLLLFLFFFQQQQSLLLLLKKKKKYYLFYAAAASLSLLLVTTTTLLLLLEEEEEPVLQMQQQQQTIIVIEEEEE-IIIIQQRRRDDDDDAAVVAEDDNETTATTACC-AAPA-AFFF-FAAT-VTAY-YILL-LVVV-VRRQ-RPPP-PAAV-AFYF-F | {
"seq0": "IFQLKYALVLEPQTEQDAETAAFATIVRPAF",
"seq1": "KLQLKYASTLEVQIEIQDADTCPFAALVRPAY",
"seq2": "LFQLKLALTLELQIEIRDVDACAFTYLVQPVF",
"seq3": "LFQLKFALTLEQQVEIRDVNT",
"seq4": "LFSLKYSLTLEMQIEIRDAETAAFVYLVRPAF"
} |
VSTVVYYYYFNVNNNDSSDDGAAAAEEEEETMMTSKKKKKGGGGGPPPPPRRRRRRRRRRKKKKKFFFFFFFFFFTSSTTYYYYYFFLFFGGGGGGEGGGEEEEESSSSSAEAAAATTATHYYHYPKSPKPPPPPGTSGSDQEEENRRNNKSKKKTAATL | {
"seq0": "VYNDGETKGPRRKFFTYFGGESAAHPPGDNKT",
"seq1": "SYVSAEMKGPRRKFFSYFGEESETYKPTQRSA",
"seq2": "TYNSAEMKGPRRKFFSYLGGESATYSPSERKA",
"seq3": "VYNDAETKGPRRKFFTYFGGESAAHPPGENKT",
"seq4": "VFNDAESKGPRRKFFTYFGGESATYKPSENKL"
} |
-V----N----K----F----P----Y----E----A----T----S----P----A----G----N----F----L----A----E----T----N----L----Q---KRRRREEEEELLLLIVLVVIYYYYYAPAAPINIIVGSGGGTTTSVLILLFIIIVVQTRHQFMFFMSSSAS---H-SKAAKPPPPPMLMMQDDDDDGAGGAQAQQSLLLLLNNNNNRRRKRYYYYYLFLLLEEDDEEEEEEASSSSTTTTTLMMMMRRRRKGGAGGLLLILTSTTTNNNNNTTKMTPPPPPDDEDDDDCDDQQQQQVAVVACCCAC | {
"seq0": "KELVYAIGTLIQFSSPMDGQLNRYLEEATLRGLTNTPDDQVC",
"seq1": "VNKFPYEATSPAGNFLAETNLQRELLYPNSTIITMSKPLDAALNRYFEESTMRGLSNTPDDQAC",
"seq2": "RELVYAIGTLIRFSAPMDGQLNRYLDESTMRALTNKPECQVC",
"seq3": "RELVYAIGSLVHFAHAPMDGQLNKYLDESTMRGITNMPDDQVA",
"seq4": "REIIYPVGVFVQMSKPQDASLNRYLEESTMKGLTNTPDDQAC"
} |
NNNNNSDDDDKKKKKNNVNNVVVVVYYYYYRRRHRAAAAAVSSASAAAAAKKQKQKTTTSLLLLLTTVTVGGGGGEEEEESSSSSDDDDDLLLLLSARAAPPPPPAQAAAHKKQKPP-PPMM-MTSS-SSDE-EEII-IIRR-RREE-EEHH-SHKK-KK | {
"seq0": "NSKNVYRAVAKKLTGESDLSPAHPMSDIREHK",
"seq1": "NDKNVYRASAKTLTGESDLAPQKPMSEIREHK",
"seq2": "NDKVVYRASAQTLVGESDLRPAK",
"seq3": "NDKNVYHAAAKTLTGESDLAPAQPMSEIRESK",
"seq4": "NDKNVYRASAQSLVGESDLAPAKPTSEIREHK"
} |
AAMAASAAAAILLVLPPPPPHAAAALLVVVMMMNMVIIVVQRRRREEEKEAAAVVPPKRRGGGGGQQQ-QPPP-SSST-SQEE-EGGG-GAEE-ETTT-TEEE-ARRR-RLLL-LYYY-YPPT-QIVV-VKEE-EGGG-GVVV-VIII-IIII-IDDD-DLIM-V----SVVV-VCCC-CILI-TGGG-GRRR-RPPP-PQQQ-QRRR-HLLL-LLFF-FVII-IYYY-YEEE-DKKK-GLLL-LFFF-LLLLLLSSSTSKKKKKRRRRRGYYNY---V----I----M----G-HHHYHYFFLYYYYYYYYYYYQQQNQFFFFFEEEEKAEAAAQKKKKKRKKRPPPPPNNNNGGGGGGVAAMGDDDADTTTTT | {
"seq0": "ASIPHLMVQEAPGQPSQGATERLYPIKGVIIDLVCIGRPQRLLVYEKLFLSKRGHYYYQFEAQKPNGVDT",
"seq1": "AALPALMIREAPGQPSEGETERLYPVEGVIIDIVCLGRPQRLFIYEKLFLSKRYHFYYQFEEKRPNGADT",
"seq2": "MALPAVMIREAKGQPTEGETERLYTVEGVIIDMVCIGRPQRLFIYEKLFLSKRYHFYYQFEAKKPNGADT",
"seq3": "AAVPAVNVRKVRGLTKRNVIMGYLYYNFEAKKPNGMAT",
"seq4": "AALPAVMVREVRGQSSEGETARLYQVEGVIIDVSVCTGRPQHLFIYDGLLLSKRYHYYYQFKAKRPGGGDT"
} |
AAAAAYYYYYEEKEELLLLLKNKQKRRRRRRIRIREEEPELILILVVVVVMMMMMEEEEEPPPPPLLLILYGGGGEEEQETTTDTIIIIIFWWAWFFFFFKRRRV-R----D----V----F----H----P----A----R----G----I----M----V----E----D----E----T----T----E----I----L----S----Y----E----P----W----N----K----E----G----K----I----P----L----A----P----L---KKKSKRRRLR----V----I----I----A----N----H----Q----G----LLLLLLYYYYYYYYYYEEEEEYYYFYLIVMIQQHVQHHHHHGRGRGMLMLLVVI-VDDD-DEED-ETSS-KLALLL | {
"seq0": "AYELKRRELVMEPLYETIFFKKRLYYEYLQHGMVDETL",
"seq1": "AYELNRIEIVMEPLGETIWFRRDVFHPARGIMVEDETTEILSYEPWNKEGKIPLAPLKRLYYEYIQHRLVDESA",
"seq2": "AYKLKRRELVMEPLGETIWFRKRLYYEYVHHGMIDDSL",
"seq3": "AYELQRIPIVMEPIGQDIAFRSLLYYEFMVHRLL",
"seq4": "AYELKRRELVMEPLGETIWFVKRVIIANHQGLLYYEYIQHGLVDEKL"
} |
EEEEEFFFFFVVAVAMMLMLKNSKNDDDDDMAQMQFFFFFEEEEDTTSTSIILIIYYYYYFFFFFAACACYYYYYNSENESSSSSKKKKKTTTTTTTTTTSSPSNLLLLLQQLQLIIIIILLLLLSSRSRLLVVALMMVMGGGGGMTMMMVVLVLIIIIVKKRKREEEEESSTSAGGGGGEEEEETTPTPIIIIILLLLLVVVVV | {
"seq0": "EFVMKDMFETIYFAYNSKTTSLQILSLLGMVIKESGETILV",
"seq1": "EFVMNDAFETIYFAYSSKTTSLQILSLMGTVIKESGETILV",
"seq2": "EFALSDQFESLYFCYESKTTPLLILRVMGMLIRETGEPILV",
"seq3": "EFVMKDMFETIYFAYNSKTTSLQILSVVGMVIKESGETILV",
"seq4": "EFALNDQFDSIYFCYESKTTNLLILRAMGMLVREAGEPILV"
} |
DNDDEFFFFFLLLILVGVVVFFFFYVVVVVYYPPPEDDDDQQNQNRRRRRYYYYYCACCCIIIIIDDEEENSNNT-L----A----S----A----P----A----G----C----S----L----L----K----Q----P----M----L----L----R----E----L----F----S----C----K----V----T----T----V----S----W----S----Q----F----A----G----P----H----S----D----E----L----L---S-SSNE-EEEAESSSHRRRRMIIIILLVLVGGGGGTTTATASVGVFFYFYEEEEEAAAAATSTTTLRLLIIIIIIKKKKKEEEEENNQNNIIIIVIVLLLKKRKSAETSAFFFFFRRKR-HSNN-SVDS- | {
"seq0": "DFLVFVYEQRYCIDNSEAHMLGTAFEATLIKENIIKAFRHS",
"seq1": "NFLGFVYDQRYAIDSLASAPAGCSLLKQPMLLRELFSCKVTTVSWSQFAGPHSDELLERILGTSFEASRIKENIVKEFRSV",
"seq2": "DFLVFVPDNRYCIENSESRIVGTVYEATLIKEQILRTFKND",
"seq3": "DFIVFVPDQRYCIENSESRILGAGFEATLIKENILKSFRNS",
"seq4": "EFLVYVPDNRYCIETNESRIVGTVYEATIIKENVLSAF"
} |
SGSGSIICICDDDDDPSPPPLVLILVVVVVKKKKKGGGGGCLCLCLFLYLVVVLVDEDDDKKKKELLQLQAAGAALMMLMGGGGGGGGGGEEEEESSSSSEEEEEHEHHISSSASPPPPPSPFASDDDDDVVVVVYYWYYAASAGSSSSTYFYYYDDEDETTTTTQSNNNQNQQQLLLLL | {
"seq0": "SIDPLVKGCLVDKLALGGESEHSPSDVYASYDTQQL",
"seq1": "GIDSVVKGLFVEKLAMGGESEESPPDVYASFDTSNL",
"seq2": "SCDPLVKGCLVDKQGMGGESEHSPFDVWSSYETNQL",
"seq3": "GIDPIVKGLYLDKLALGGESEHAPADVYASYDTNQL",
"seq4": "SCDPLVKGCLVDEQAMGGESEISPSDVYGTYETNQL"
} |
QRQQRAAAKKDDDEECSSSSDDDDKPPPPPTTTSSEEEEELLLLLLLLLLPPPPPGGGGGNSSTTVVVVVEEGEEAAAAAEEEEEQHQHHAAASSEEEQEYKYKKSSSASKKKTTKNKNNYYYYYTTTATLLLLMTTVTTEEEDETLTTTPPPPPVVVVVFFFLLLVLLL | {
"seq0": "QADCDPTELLPGNVEAEQAEYSKKYTLTETPVFL",
"seq1": "RADSDPTELLPGSVEAEHAEKSKNYTLTELPVFV",
"seq2": "QADSDPTELLPGSVGAEQAEYSKKYTLVETPVFL",
"seq3": "QKESDPSELLPGTVEAEHSQKATNYALTDTPVLL",
"seq4": "RKESKPSELLPGTVEAEHSEKSTNYTMTETPVLL"
} |
TTTTTRRLRRAAVSATVTTTDDDEDLVLLVPPPPPPPPPPPPEEPIIILIAAAAAGGGNDRRRRRVVLLVGGGGGTTSPTGGGGGVVVAVNNNDNVILLLEEEETYFHHYVVVVIIILLLEEKKKLLLLLTTTTTPSPPPCCFFCGGGGGSDEDDKKRKKMMMAMVVTAVKKKKKDDEE-HHNK-KKKR-FFFF-DDDD-KRYKK | {
"seq0": "TRATDLPPPIAGRVGTGVNVEYVIELTPCGSKMVKDHKFDK",
"seq1": "TRAVDVPPPIAGRVGTGVNIEFVIELTSCGDKMVKDHKFDR",
"seq2": "TLVTDLPPEIAGRLGSGVNLEHVLKLTPFGERMTKENKFDY",
"seq3": "TRSTELPPELANRLGPGADLEHVLKLTPFGDKAAKEKRFDK",
"seq4": "TRATDVPPPIADRVGTGVNLTYILKLTPCGDKMVKK"
} |
PPPPPAAAKVAAAAAHGGGGSSSSSLLLLLSRTKTSSSPSSSSSSLCLCCWWWWAAGATGKKKKENVNNNLLLLMLVLLLVAVAKGGGGSFYYYHWQWQW---A----M----M----P-EFFFFVVVVV---L----I----V----G----V----L----G----Y----R----A----E----I----V----L----F----Y----S----G----Q----C----P----V----I----E----N----P----T----K----F----R----T----P----G----D----E----K----D----R----R----P----A----Y----L----V----M-AGAGGSESEKGGGGRKKKAKTATATKKKKKRRRRRSSSSSTTTTTPPPPPPPPPPLLLLL | {
"seq0": "PAAHSLSSSLWAKNLLVGFWEVASGKTKRSTPPL",
"seq1": "PAAGSLRSSCWGKVLVAGYQFVGEGKAKRSTPPL",
"seq2": "PAAGSLTSSLWAKNLLVGYWFVASGKTKRSTPPL",
"seq3": "PKAGSLKPSCWTKNLLAGYQAMMPFVLIVGVLGYRAEIVLFYSGQCPVIENPTKFRTPGDEKDRRPAYLVMGEGAAKRSTPPL",
"seq4": "PVAGSLTSSCAGENMLKSHWFVGKRKTKRSTPPL"
} |
AAAVVFFSFFFFLFFSSASHNNNNNDDDDDAASAALLILLEEEEELILLLDDDDDVVLVISSSSSLLLLLKRRRSIVVITGGGGGEEEEDQQQQQDDD-DNNN-NQLL-LDDS-EKKN-EEHQ-HI----R----D----D----K----A----L----Q----G----M----I----IIV-LAAA-AAAA-ACCC-AQQR-QDDE-DTEG-SPPP-PSSE-SAAV-EKSK-EKKK-EDDD-DGGD-GKKK-KSSA-S | {
"seq0": "AFFSNDALELDVSLKIGEQDNQDKEIRDDKALQGMIIAACQDTPSAKKDGKS",
"seq1": "AFFSNDALEIDVSLRVGEQDNLDKHIAACQDEPSASKDGKS",
"seq2": "ASLANDSIELDLSLRVGEQDNLSNQVAACREGPEVKKDDKA",
"seq3": "VFFSNDALELDVSLRIGEQ",
"seq4": "VFFHNDALELDISLSTGDQDNLEEHLAAAQDSPSEEEDGKS"
} |
RKKRKKKKKKLLLLLT-TTSI-MMQV-IVVP-QPPM-LLIL-PLLK-SKKL-LLAF-FFFT-TTTY-YNYV-VVAT-ETTV-VIVE-EEKV-VVVQ-QQQA-ASAI-IIIL-YLYT-TNTW-WWWG-GGGG-GGGD-DDDK-KKKP-PPPE-EEEE-QEKE-EEEV-V-IS-F-FP-P-P | {
"seq0": "RKLTIVPMLKLFTYVTVEVQAILTWGGDKPEEEVSP",
"seq1": "KKL",
"seq2": "KKLTMIQLPSLFTYVEVEVQAIYTWGGDKPEQEVFP",
"seq3": "RKLTMVPLLKLFTNVTIEVQSILNWGGDKPEEE",
"seq4": "KKLSQVPILKAFTYATVKVQAIYTWGGDKPEKEIFP"
} |
IVIIVLLLLLGGGGGLLILLGGGGGVIVVV--D----V----D----N----H----K----S----L----H--EEEEEQKQQQNFGFFWWWWWEDQQDQNKQQ--DD---NN---LL---FF-LLMLLEEDDESSSSSPPPSPFFFFFVVVVIGGGGGGGGGGVVVVVYYYYYILIFIIVIIIGGGGGADVTDRKRRRPPPPPDTDDDGGGGGKMEEMYYYYYKKQKKLLVVL | {
"seq0": "ILGLGVEQNWEQLESPFVGGVYIIGARPDGKYKL",
"seq1": "VLGLGIEKFWDNLESPFVGGVYLVGDKPTGMYKL",
"seq2": "ILGIGVDVDNHKSLHEQGWQKDNLFMDSPFVGGVYIIGVRPDGEYQV",
"seq3": "ILGLGVEQFWQQDNLFLDSSFVGGVYFIGTRPDGEYKV",
"seq4": "VLGLGVEQFWDQLESPFIGGVYIIGDRPDGMYKL"
} |
TDEEDCCCLVLLAGATTTPTIILLLKKKHKGGGGGSSTESLLLLLPPPPPNNNNNTTTHAHHHHHDDDEQPPPSPVMMFMLLLLLRRRRRAAAAATTSTTVIVVVYYFFFEEEEEVVVLVKKKKKDDLDDIVVVVVVVTIRRRRREEEEEFFFFFDEEEESSAAAEEEEE | {
"seq0": "TCLTIKGSLPNTHDPVLRATVYEVKDIVREFDSE",
"seq1": "DCLTIKGSLPNTHDPMLRATIYEVKDVVREFESE",
"seq2": "ECATLKGTLPNTHDPMLRASVFEVKLVVREFEAE",
"seq3": "ELGPLHGELPNHHESFLRATVFELKDVTREFEAE",
"seq4": "DVATLKGSLPNAHQPMLRATVFEVKDVIREFEAE"
} |
FFFFFEEEEES-S-ST-T-KI-V-VS-S-PG-G-EH-H-HS-S-SV-V-LF-F-FT-T-TC-C-CI-I-IL-L-LS-S-SH-H-QD-D-DY-Y-LP-P-PS-S-SK-K-KT-T-TP-P-PK-K-KA-A-TD-D-NA-A-AL-L-LA-A-AI-I-INGANNFFFFF | {
"seq0": "FESTISGHSVFTCILSHDYPSKTPKADALAINF",
"seq1": "FEGF",
"seq2": "FESTVSGHSVFTCILSHDYPSKTPKADALAIAF",
"seq3": "FENF",
"seq4": "FESKVPEHSLFTCILSQDLPSKTPKTNALAINF"
} |
EEEEEAAAAATTTTTLLLLLAAAAALLLLFPSPPPQQQQQVVVIVSSSPSEQEEAVVVVV-PP--IIIVIKKKKKVVVVVDHFNNATTTAQTTGQKKKKKEEEEETTTTTGGGYGMMMMMEEEEEPPPAPDEDDDFYY-FRRRRRLLLLLEEEEEGGGKGAAAAAKKKVK | {
"seq0": "EATLALPQVSEVIKVDAQKETGMEPDFRLEGAK",
"seq1": "EATLALSQVSQVPIKVHTTKETGMEPEYRLEGAK",
"seq2": "EATLALPQVSEVPIKVFTTKETGMEPDYRLEGAK",
"seq3": "EATLALPQIPEVVKVNTGKETYMEADRLEKAV",
"seq4": "EATLAFPQVSAVIKVNAQKETGMEPDFRLEGAK"
} |
LLLKLPPPPPRRRRRVLAVLGGGGGEDEDDAVVVVAAAAAVVVLLAAAAAVIVVITATAAASSAAVVTVV-M-MMAAAAAEVPPVLHLLLRKRKKGDGDDNRNNNDDDDDMLMLLVIIIIAAAAAIVIIVYLYLLIILIILLLLLEKEEKNNNDNTTTTTLLILL | {
"seq0": "LPRVGEAAVAVTAVAELRGNDMVAIYILENTL",
"seq1": "LPRLGDVAVAIASVMAVHKDRDLIAVLILKNTL",
"seq2": "LPRAGEVAVAVTSTAPLRGNDMIAIYLLENTI",
"seq3": "KPRVGDVALAVAAVMAPLKDNDLIAILILEDTL",
"seq4": "LPRLGDVALAIAAVMAVLKDNDLIAVLILKNTL"
} |
-M----I----L----E----K----A---NDDNNDEDDS--GGGMMMMMPPPPPGSGGGVVVTVNNNNNGGGGGCCC-CLLLLLPSPRRLLLLLPPPPPVIVTSTTTQRAAAAASSSSSRRRRRLLQMMVAAAADDEEEKKKKKIIVLIKKKKKSSTSSNAHQHLLLLLAAVVVKKKKKNNDDDNNSNNQSASSIVTTTSSSSSDDQQQVVVVVVTYYYLMLLLGGGGGHSHHHIIIIASVIVIASSSS | {
"seq0": "NDMPGVNGCLPLPVTASRLVDKIKSNLAKNNQISDVVLGHISA",
"seq1": "MILEKADEMPSVNGCLSLPITASRLADKIKSALAKNNSVSDVTMGSIVS",
"seq2": "DDGMPGVNGCLPLPVTASRQAEKVKTHLVKDSATSQVYLGHIIS",
"seq3": "NDGMPGTNGLRLPTQASRMAEKLKSQLVKDNSTSQVYLGHIVS",
"seq4": "NSGMPGVNGCLRLPSRASRMAEKIKSHLVKDNSTSQVYLGHAIS"
} |
AVAAAAVCAMDDDDDDDDDDPPPPPMIMMMGAGGGVVVVVTTTTTLIILIGGGGGSSSSSGGGG-FFFFFYYYYYAAAAATTTTTRKRRRKKKKK--L----V----P----K----I----S--SSSNTTTTTTRRRRRFFFFFGGGGGIIIIVIIIIILL-LLIIVIILLLLLHQHHHVQVVLEASSSLLLLIAEAASLLLLLYYYYYHTTKTENEEQVVVVIFFFVFWRWWLAAAAAFV-F-EDDED | {
"seq0": "AADDPMGVTLGSGFYATRKSTRFGIILILHVELALYHEVFWAFE",
"seq1": "VVDDPIAVTIGSGFYATKKSTRFGIILILQQALELYTNVFRAVD",
"seq2": "ACDDPMGVTIGSGFYATRKLVPKISSTRFGIIVLHVSLALYTEVFWAD",
"seq3": "AADDPMGVTLGSGFYATRKNTRFGIILILHVSLALYKEVVWAFE",
"seq4": "AMDDPMGVTIGSFYATRKTTRFGVILILHLSISLYTQIFLAD"
} |
MMMLLPPPPPLLLLLSSANSEEEEENNDNNIIIIISSSRSSSKSSTLATTTTKNNAEGASVVLIILLLLILLLLLFFLFFKKKKKIIFFFSSSTSYYYYYRRRRREETEEAAAAADDDDDAAAAAYYYYYWWWWWRRKRRIIIVVKKKQKCCRRRRRLLLKKKKK | {
"seq0": "MPLSENISSTTAVLLFKISYREADAYWRIKCRK",
"seq1": "MPLSENISSLTEVLLFKISYREADAYWRIKCRK",
"seq2": "MPLAEDISKAKGLLLLKFSYRTADAYWKIKRLK",
"seq3": "LPLNENIRSTNAILLFKFTYREADAYWRVQRLK",
"seq4": "LPLSENISSTNSIILFKFSYREADAYWRVKRLK"
} |
LLLLLIIIVMQQMQQNQQQQLLLLLMMIILSSSSSSSSSSDDNNDAAAAADDDDD--S----I----G----M----P----S----W----F----G----V----F----R----G----F----G----E----L----V----W----D----S----I----K----D----Q----F----D----P----A----D----C----E----P----D----A----P----I----K----I----L----V----T----P----E----L----G----K----E----G----P--HHAQHLLLMLTTTTPDDDDDCILLLGGGGGEEEEEYYYYYGGGGGIIIIIKKKKPTTTTKGGGGASSSSSIIMVIFFYYFAAPAASNNNNEQQQQIIRRVPPPPPEEERA | {
"seq0": "LIQNLMSSDADHLTDCGEYGIKTGSIFASEIPE",
"seq1": "LIQQLMSSDADHLTDIGEYGIKTGSIFANQIPE",
"seq2": "LIMQLISSNADSIGMPSWFGVFRGFGELVWDSIKDQFDPADCEPDAPIKILVTPELGKEGPALTDLGEYGIKTGSMYPNQRPE",
"seq3": "LVQQLISSNADQMTDLGEYGIKTGSVYANQRPR",
"seq4": "LMQQLLSSDADHLPDLGEYGIPKASIFANQVPA"
} |
SSASADDTDDGGRGGVIVVIQHKQQQSQQSPPPPPEEEEE-HH-K-YY-Y-SS-S-EE-E-NN-N-CC-C-KK-K-TV-T-TT-T-HH-H-SS-S-EE-E-IV-I-KK-K-IV-V-TT-T-RK-R-VT-V-CV-A-AD-A-TV-V-DD-D-SS-S-KR-K-LL-L | {
"seq0": "SDGVQQPE",
"seq1": "SDGIHSPEHYSENCKTTHSEIKITRVCATDSKL",
"seq2": "ATRVKQPEHYSENCKVTHSEVKVTKTVDVDSRL",
"seq3": "SDGVQQPE",
"seq4": "ADGIQSPEKYSENCKTTHSEIKVTRVAAVDSKL"
} |
FFFFFVIIVI-VV-VMG-LGVIIILVVITVDDDDDEGEEAKRGNRRRRRRLLLLLYYYYYAQAAQSSSSSTNNNNDNNDNGLEAIEQQQQDDDNDLLLLLTRRTRVVVTVNSSNSMLMMLSRRS-IIIIIG-GGGV-IVID-DDDV-IVIK-QKQV-AAAP-PPP | {
"seq0": "FVMVVDEKRLYASTDGEDLTVNMSIGVDVKVP",
"seq1": "FIVGIVDGRRLYQSNNLQDLRVSLRI",
"seq2": "FIVIIDEGRLYASNNEQDLRVSMRIGIDIQAP",
"seq3": "FVLITDENRLYASNDAQNLTTNMSIGVDVKAP",
"seq4": "FIVGLVDARRLYQSNNIQDLRVSLIGIDIQAP"
} |
KKNKKGGGGGVVLVVVVVIVLLLLLCCCCMLLLLLKQKKQLLLLLAAAAAIVIIVAAVAADDDDDKKKKKQHQQHKKKKKILILFEEEEEDDDEDPPPPPQMQQMPPPPPMSMMTSSSSSGGGGGLMLMMYYYYYSSSSSCACCALDLLDDDEDDKKKKKGGGGGWWWWYGGGGGFVFFMRRRRRAAAAA | {
"seq0": "KGVVLCLKLAIADKQKIEDPQPMSGLYSCLDKGWGFRA",
"seq1": "KGVVLCLQLAVADKHKLEDPMPSSGMYSADDKGWGVRA",
"seq2": "NGLVLCLKLAIVDKQKIEDPQPMSGLYSCLEKGWGFRA",
"seq3": "KGVILCLKLAIADKQKLEEPQPMSGMYSCLDKGWGFRA",
"seq4": "KGVVLMLQLAVADKHKFEDPMPTSGMYSADDKGYGMRA"
} |
KKRKAPPSPALLLFLRRRRREEDEEKQKQKIIMMILLLLLVIVVIRQKKKEEEEEVVVVVWWWWWASAAAVVVGVKRKKKVVVVVDDDDDTTTTTLLLLLHNNHNEEEAEEEEEEQQAKQGGGGGSSSESKKKSKVVVIRSSETSHHHHHRRRARPPPPPAAAAAKKKKKPPPPPKKKTKAAAALKAPKK | {
"seq0": "KPLREKILVREVWAVKVDTLHEEQGSKVSHRPAKPKAK",
"seq1": "KPLREQILIQEVWSVRVDTLNEEQGSKVSHRPAKPKAA",
"seq2": "RSLRDKMLVKEVWAVKVDTLNEEAGSKVEHRPAKPKAP",
"seq3": "KPFREQMLVKEVWAGKVDTLHAEKGESITHAPAKPTAK",
"seq4": "AALREKILIKEVWAVKVDTLNEEQGSKRSHRPAKPKLK"
} |
KKKKKSSSSSWWWWWKKKKRFF-FFNRTNNRTRRRFFFFFGNGGNGGGGGKKRKKILLILPSPPPGGGGGAASAANNNNDSDDDDILLLLRRRRRLILLLMMIMMSSSSSNNSNNTESTEGGGGGFFFFFKKKKKWWWWWLILLIHYYEYLLILLQQHQQLFVLF | {
"seq0": "KSWKFNRFGGKIPGANSIRLMSNTGFKWLHLQL",
"seq1": "KSWKFRTFNGKLSGANDLRIMSNEGFKWIYLQF",
"seq2": "KSWKTRFGGRLPGSNDLRLISSSGFKWLYIHV",
"seq3": "KSWKFNRFGGKIPGANDLRLMSNTGFKWLELQL",
"seq4": "KSWRFNRFNGKLPGADDLRLMSNEGFKWIYLQF"
} |
QQQQQRRRRRGGGGGVIIIIFFFFFAAAAMNNRNKPPNSSVVMMVAAGGALLLLLRRRRRASAAASSSSSTSMMMVVVVVHHNNNGNGGGRRKRKAASAAPPPPPSSSSALIVVVHHHHHQTMMTHHHHHTTTTTGGGGGYYVVYQQQQQPLPPPAAYYALLLLLKKNNNVVVVVIIIILFYFFFEEEEE | {
"seq0": "QRGVFANPVALRASTVHGRAPSLHQHTGYQPALKVIFE",
"seq1": "QRGIFANPVALRSSSVHNRAPSIHTHTGYQLALKVIYE",
"seq2": "QRGIFARNMGLRASMVNGKSPSVHMHTGVQPYLNVIFE",
"seq3": "QRGIFANSMGLRASMVNGRAPSVHMHTGVQPYLNVIFE",
"seq4": "QRGIFMKSVALRASMVNGKAPAVHTHTGYQPALNVLFE"
} |
WWWWWILIIIRRRRRLLLILLLILAHHHNHLLLLLQQQQQGSSSSVVVFFLIILLLLCGGDDDDDEEDDDFFFFFEEEEEPPPPPHHHHHAAAQPP-TTTGGGGGPPPPPWWWWWTTTTTKKKKKFFFFFHHQSRVVVAAGGGGGWWWCCPPPPPMVMMMSSSSSCVVCCYYFYYLLLLLCCCAAKDDDD | {
"seq0": "WIRLLHLQGVLLDEFEPHAPGPWTKFHVGWPMSCYLCK",
"seq1": "WLRLLHLQSVILDEFEPHAGPWTKFHVGWPVSVYLCD",
"seq2": "WIRLIHLQSVICDDFEPHATGPWTKFQVGWPMSVFLCD",
"seq3": "WIRILNLQSFLGDDFEPHQTGPWTKFSAGCPMSCYLAD",
"seq4": "WIRLAHLQSFLGDDFEPHPTGPWTKFRAGCPMSCYLAD"
} |
LLLLLTTTTTNNNNNIIIIIVLLVVSSSSSEEEEEQQQKEIILIIIIIVVEEEEEFFFFFIIIVIFFFFFPEETTVVVIVPPPPPKRKKKQYYQQCSSCCMMMMMNKNNNEEEEEVVVVVYYHYYPPPPPYYTYYPPPPPNSSSVGGGGGDDDDDNNNNTKRKRKLLLLLLLLLLRRRRRETTAAFGTFF | {
"seq0": "LTNIVSEQIIEFIFPVPKQCMNEVYPYPNGDNKLLREF",
"seq1": "LTNILSEQIIEFIFEVPRYSMKEVYPYPSGDNRLLRTG",
"seq2": "LTNILSEQLIEFIFEVPKYSMNEVHPTPSGDNKLLRTT",
"seq3": "LTNIVSEKIVEFVFTIPKQCMNEVYPYPSGDNRLLRAF",
"seq4": "LTNIVSEEIVEFIFTVPKQCMNEVYPYPVGDTKLLRAF"
} |
EEQQQVIIMIYYYYYRRRRRVVVVVLLLLLHNQNNHHHNNAAQLAGGGGGTTTTTYYYYFTTTTTEEDEEVVVVVQQQEQVVVVVVVVVVVVIVIKSKQKQQQQQEKEEENNNNNFFFYYILVIIGGGGGNNNNNMMMIMPPPPPGGGGGSPTTTGGGGGAAAARGGGGGPPPEPLLLLLLLLFLRRRRR | {
"seq0": "EVYRVLHHAGTYTEVQVVVKQENFIGNMPGSGAGPLLR",
"seq1": "EIYRVLNHAGTYTEVQVVVSQKNFLGNMPGPGAGPLLR",
"seq2": "QIYRVLQHQGTYTDVQVVIKQENFVGNMPGTGAGPLLR",
"seq3": "QMYRVLNNLGTYTEVEVVVQQENYIGNIPGTGAGELFR",
"seq4": "QIYRVLNNAGTFTEVQVVIKQENYIGNMPGTGRGPLLR"
} |
AAAAAAKAQKKKKNRRRRKG---G-TTTTTRQQDQWWWWWKRRGREGEEEPPPPNTSSSNTTTTTTRRKRRRRRRYYYHYSASSSGGGGGQQQSLSSSNSIVI-ILLL-AQQQ-QSSS-SDDN-DVVV-VEGE-GEEE-ELIL-LCRC-RVVV-VVVVVVNNNSN | {
"seq0": "AAKRTRWKEPTTTRYSGQSILQSDVEELCVVN",
"seq1": "AKKRTQWRGPSTRRYAGQSVLQSDVGEIRVVN",
"seq2": "AAKRTQWREPSTRRYSGQSILQSNVEELCVVN",
"seq3": "AQNKGTDWGEPSTKRHSGSNVS",
"seq4": "AKRGTQWRENNTRRYSGLSIAQSDVGELRVVN"
} |
PPPPPTTTTTRRRRRGGGNGAIAAAP-SSSFFFFFRRNNGAAAAAQQKTKLIFFFIIIIIRKQQRYYYYSVVVIVPPEEENEDDDVVVIVLLLLLAAAAVLLLLLPPQPPTAAAAEDDDDKKKKKGGAATGGGGHVVNLLYYFFFPPPSPR-RQRA-AAA | {
"seq0": "PTRGAPFRAQLIRYVPNVLALPTEKGGVYPRA",
"seq1": "PTRGIFRAQIIKYVPEVLALPADKGGVYP",
"seq2": "PTRGASFNAKFIQYVEDVLALQADKAGNFPRA",
"seq3": "PTRNASFNATFIQYIEDILALPADKAGLFSQA",
"seq4": "PTRGASFGAKFIRSVEDVLVLPADKTHLFPRA"
} |
IIIILNNNNNWWWWWNDDDDGGGGGITTTTRRRRRLLILLMMTMTDEDEDNDDEDAAAAAHHHHHTTTTTVIMVLAACACAAAAAPPAPPCSCSCFFYFYFFFFFQQQQQHHHHHDDDDDPPTPPVLVMVMAMAMATATARRERQRVRKRMMMMMVVIVTVVVVLEEEEQRRRRRDDDDDPPPKPRRRRR | {
"seq0": "INWNGIRLMDNAHTVAAPCFFQHDPVMARRMVVERDPR",
"seq1": "INWDGTRLMEDAHTIAAPSFFQHDPLATRVMVVERDPR",
"seq2": "INWDGTRITDDAHTMCAACYFQHDTVMAERMIVERDPR",
"seq3": "INWDGTRLMEEAHTVAAPSFFQHDPMATRKMVVERDKR",
"seq4": "LNWDGTRLTDDAHTLCAPCYFQHDPVMAQRMTLQRDPR"
} |
QKKQQWWWWWLLLLLNNNKNTTTSVILLTLIII-INQQQQLVVLVYYYYTKDDREDDDDSMLLLLDRREKVIIIVGGAGGTTTTTSANNSQQQQQNNNNNPAAPPFFFFFDDDHDKKKKMVVVIVLLLLLFFFFFLLLLWR--RRAAASEIII-IAAA-AVAAVEMMMMLNRKNQAAAAALLLIIMMMMLKKKKEAAAESSSSSS | {
"seq0": "QWLNTIINLYKDMDVGTSQNPFDKVLFLRAIAVMNALMKAS",
"seq1": "KWLNTLIQVYDDLRIGTAQNAFDKVLFLAIAAMRALMKAS",
"seq2": "KWLNTLIQVYDDLRIATNQNAFDKVLFLAIAAMKALMKAS",
"seq3": "QWLKSTQLYRDLEIGTNQNPFHKILFLRSVMNAIMKES",
"seq4": "QWLNVLIQVTESLKVGTSQNPFDMVLFWREIAELQAILESS"
} |
LLLLLEEEEETTTTTVVVLVAKKKKTMIMMNHHYHFYYFYDDDDDAAVAVKKKKKEEEESEQYEYGHGGGKKKKKCSSSKIIIIIDEEDDLLFLLLLVLLPPPPPIIFIFQQQQQGGGGGGGGGGEEEEERRRRRAAAATVVVVVADDADYYYYYPPPPPSTSSSAMVVFIMIIVRRRRREEEE-DDDD-IVVVVGGGGGFFFFF | {
"seq0": "LETVATNFDAKEEGKCIDLLPIQGGERAVAYPSAIREDIGF",
"seq1": "LETVKMHYDAKEQHKSIELLPIQGGERAVDYPTMMREDVGF",
"seq2": "LETVKIHYDVKEYGKSIEFVPFQGGERAVDYPSVIREDVGF",
"seq3": "LETLKMYFDAKEEGKSIDLLPIQGGERAVAYPSVIREDVGF",
"seq4": "LETVKMHYDVKSYGKKIDLLPFQGGERTVDYPSFVRVGF"
} |
GGGGGAAAAALLLLMEEEEEGAAGGY--Y-T--T-V--V-K--R-S--S-Q--Q-EEEEQQQQQQGGGGGKKRKRLLLLLACCASLLLLLGGGGGIILIIVAAVATTTTSVIIIIVVVVVSAASSFFFFFGGGGGSSSSG---A-NKKNKNNNNNEEKEEVIIIILLLLLKKKKKSNNKAEEEEE----L----E----W----R----ARCCRCWWWWWVVVVVRRRRRPPPPPMMMMM | {
"seq0": "GALEGYTVKSQEQGKLALGIVTVVSFGSNNEVLKSERWVRPM",
"seq1": "GALEAEQGKLCLGIATIVAFGSKNEILKNECWVRPM",
"seq2": "GALEAEQGRLCLGLATIVAFGSKNKILKNECWVRPM",
"seq3": "GALEGYTVRSQEQGKLALGIVTIVSFGSANNEILKKERWVRPM",
"seq4": "GAMEGQQGRLSLGIASIVSFGGKNEILKAELEWRACWVRPM"
} |
NNQNQEEEEEGGSGSI-IIIR-RRQA-AAAQ-QQQI-ILVQMQEEVVVVVDDDDDSSSSSVVIVIAAAAAKKRRREEEEECCCCCNTYNYRRRRRFFIFFVVVIVVVTTTTTTTTFFLFIAAPPPAAEAETTTTTVIFFFSSSSSMMLMLDDDDDIIRKRGGGGGAAVLVSSGGGLLLML | {
"seq0": "NEGIRAQIQVDSVAKECNRFVVTFAATVSMDIGASL",
"seq1": "NEGMVDSVAKECTRFVVTFAATISMDIGASL",
"seq2": "QESIRAQIQVDSIARECYRIVTTLPETFSLDRGVGL",
"seq3": "NEGIRAQLEVDSVARECNRFITTFPATFSMDKGLGM",
"seq4": "QESIQAQVEVDSIARECYRFVTTIPETFSLDRGVGL"
} |
LIIIIAVVVVDDDDDLIILIKAGGGRSERETDDTDLLLLLAATAA-N----A----L----L----V----F----A---LLILLMMMMMRKKRKASAAA-N----N---YFFHFMLLMLAAAAAASSSSRNERENQKNK-KKRKAAGSGPPPPPKRKKKLLLLLRLLLLVIIVIYWFYWIVTITI-IIIF-PLVE-EKER-RRRG-GGGH-NHNT-TTTFFFFL | {
"seq0": "LADLKRTLALMRAYMAARNAPKLRVYIIFERGHTF",
"seq1": "IVDIASDLANALLVFALMKSNNFLASNQKAPRLLIWVF",
"seq2": "IVDIGEDLTIMKAFLASEKKGPKLLIFTIPERGNTF",
"seq3": "IVDLGRTLALMRAHMASRNRSPKLLVYIILKRGHTF",
"seq4": "IVDIGEDLALMKAFLASEKKGPKLLIWTIVERGNTL"
} |
STTTSPPPPPLLVVMGGVVGIIIIIQQQQQVIIIIEEEEEDEEEEIIIITCCCCCEEEDEIIMMIHTTTTKKKKKSEDDDEEPPELLLLLGGGGGKKKKK---T----K----D----D----H----L-DGEDDVTVVTFFFLFILLLLAGGGAVAAAFQRRRRAAAALEEDDEYYYYYDDDDDLLLLL----IQQ--QVV--VMA--VLLLLL | {
"seq0": "SPLGIQVEDICEIHKSELGKDVFIAVQAEYDLQVML",
"seq1": "TPLGIQIEEICEITKEELGKGTFLGARAEYDLQVAL",
"seq2": "TPVVIQIEEICEMTKDPLGKEVFLGARADYDLL",
"seq3": "TPVVIQIEEICDMTKDPLGKTKDDHLDVLLGARADYDLL",
"seq4": "SPMGIQIEETCEITKDELGKDTFLAFRLEYDLIQVVL"
} |
GDGAGIVVV-LILVVAAAEENTTTTRRRQQSSSSREEEEELLL--FVIVVKKKKKKEKEEEEEDDDDDDD-T-VVASSSTVVVVTVVVLLPPPPPLHHKKFYFYYRRRRRMMMMMDDDDDRKRKKLLLLLNNNAAWWWWYLTNCCKKKGKTTTTTRHRRRAASAAKKKKKQMMGMKRRRREAAYYYKYRKLLLFFIIIVLFMFMWFFFIIGGGGGGGGGG | {
"seq0": "GILANRSELFKKEDAVVPLFRMDRLNWLKTRAKQKEYLIFFGG",
"seq1": "DVIATRSELVKEEDTSVVPHYRMDKLNWTKTHAKMRAKLIMFGG",
"seq2": "GVLATRSELIKKEDSVVPHFRMDRLNWNKTRSKMRAYLIFFGG",
"seq3": "AVVETQSEVKEDDVSVLPKYRMDKLAWCGTRAKGRYRFVMIGG",
"seq4": "GVETQREVKEDDVTTLPKYRMDKLAYCKTRAKMRYKFLWIGG"
} |
GRGGGRARRVPSAASSTSTTDDDQNFFFFFGGGGGLLLLLHNNNNRLRRRWWWWWTSTTIIVIIVPKPPSKKKKKYYYYYGGGGGVVVVVLLPLLGGGGGFFFFFHKHHHLLLLLYHYYYCCCCCGNGGGLILLLEQEEQQEQQENNNNSFFFFFILLLLIMLIIDNDLDRKRRKTTTT-TRTTT | {
"seq0": "GRPSDFGLHRWTIPKYGVLGFHLYCGLEQNFIIDRTT",
"seq1": "RASTDFGLNLWSVKKYGVLGFKLHCNIQENFLMNKTR",
"seq2": "GRASDFGLNRWTIPKYGVPGFHLYCGLEQNFLLDRTT",
"seq3": "GRATQFGLNRWTIPKYGVLGFHLYCGLEQNFLILRTT",
"seq4": "GVSTNFGLNRWIVSKYGVLGFHLYCGLQESFLIDKT"
} |
VTVISQQQEQCCCCGDDDDDVAATATDTEDLVLLVGAGSSHHHHHRGRRGVDVVDYYYYYQKQQQEEEAEN-HRKKIKKVNNNNNYYYYYEEEE-VVVVVKKKKKGGGGALVPVFLLLLLYNKKKDNNNNDEDDEAAAAAGGGGGAAAAA-S--SYFYSFWRRRRCFCCCGRGARGGGGGLGLLGGGGGGNNNKNLFFFFLLLLLTTTTLSPSSPAAAAA | {
"seq0": "VQCDVTLGHRVYQENKNYEVKGLLYDDAGAYWCGGLGNLLTSA",
"seq1": "TQCDADVAHGDYKEINYEVKGVLNNEAGASFRFRGGGNFLTPA",
"seq2": "VQCDATLGHRVYQEHKNYEVKGPLKNDAGAYRCGGLGNFLTSA",
"seq3": "IECDTELSHRVYQARKNYEVKGVLKNDAGASRCAGLGKFLTSA",
"seq4": "SQGDADVSHGDYQEKVNYVKAFLKNEAGASFRCRGGGNFLLPA"
} |
EEETEHHHHHYFFYYLLLL-LLLF-IIII-NDDN-LLLL-IIIIVTTTTSPPPPPEEEEERRRRR----E----V----NLLLLLLLLILTTTTTTTTTTNNSNNGGGGGAAAAAEEEEESTTSEVVVVITTTTTLLLLLFFFFWVVVVVAAAAAEEQEEGGGGGEDEQEDDEDDGAAGG | {
"seq0": "EHYLLINLITPERLLTTNGAESVTLFVAEGEDG",
"seq1": "EHFLLIDLITPERLLTTNGAETVTLFVAEGDDA",
"seq2": "EHFLLIDLITPERLLTTSGAETVTLFVAQGEEA",
"seq3": "THYLFINLITPERLITTNGAESVTLFVAEGQDG",
"seq4": "EHYVSPEREVNLLTTNGAEEITLWVAEGEDG"
} |
ALL--TTTTTPPPPPQMTTTTTTLIESEDNAMLMMRRRKKQQQRR----DPPSPPIIIVITTTTSIIIIIDDDDDRRREKYYYHYNDNGGSASSSAAASAKKKKKATTSEMMIMMTLAGGEEEEEVTTSTNNNNNYYYYYRRRRRHHHHHFFFFFAAPTAASASSWWWWW | {
"seq0": "ATPQTEARQPITIDRYNSAKAMTEVNYRHFAAW",
"seq1": "LTPMTSMRQPITIDRYDAAKTMLETNYRHFASW",
"seq2": "LTPTTELRQSITIDRYNSAKTIAETNYRHFPAW",
"seq3": "TPTLDMKRPVTIDEHGSSKSMGESNYRHFTSW",
"seq4": "TPTINMKRDPISIDKYGSAKEMGETNYRHFASW"
} |
VIVIIENEEEAAHAASSSSSFFFFFRRRRRNDDDDGG-GGSS-SSSL-LLYYYYYTVVVVCAGAGFFYFYEEE-EPPP-PGGG-GSSN-TEEE-EKKK-KAIVIVYYFFFLLLLLSTTETSSSSSEEEEEYTTTTGGGGGVVVETVVAVVK----YFYYYATAAQSSSSSQHHHHKRKRKGDAGARRRRKVTTVT | {
"seq0": "VEASFRNGSSYTCFEPGSEKAYLSSEYGVVKYASQKGRV",
"seq1": "INASFRDGSLYVAFEPGSEKIYLTSETGVVFTSHRDRT",
"seq2": "VEHSFRDYVGYEPGNEKVFLTSETGVAYASHKART",
"seq3": "IEASFRDGSLYVAFIFLESETGEVYASHRGRV",
"seq4": "IEASFRDGSLYVGYEPGTEKVFLTSETGTVYQSHKAKT"
} |
ILIILVVMLVAAAAATAASATTTTTKRRRRGGGGGSSSSAGGGSGRRRRRFFFFFTMTTTYFHHYGDGGGFFVFFAPPPPAAAAAIFIILLLLLLRRRRRSGAASCRCCCTETTEKMKKKWWWWWGGRWGQKQQQRRRRRVVVVVAAPPSSSSSSSVSSSAANNAQQQQQVILLIYFYYYEEHHEHHHHHRKRRRMLMMLVVVVIEEEEE | {
"seq0": "IVATTKGSGRFTYGFAAILRSCTKWGQRVASSAQVYEHRMVE",
"seq1": "LVAATRGSGRFMFDFPAFLRGREMWGKRVASVAQIFEHKLVE",
"seq2": "IMAATRGSGRFTHGVPAILRACTKWRQRVPSSNQLYHHRMVE",
"seq3": "ILASTRGSSRFTHGFPAILRACTKWWQRVPSSNQLYHHRMVE",
"seq4": "LVAATRGAGRFTYGFPALLRSCEKWGQRVSSSAQIYEHRLIE"
} |
NNNNNNNNNNTSSTTEDEEDSGGGGYYYYYLLLLLVMMMMMLLLLQQQQQQQQQQEESEEEEEEELNRNNHYHYHFLFFFSKKSSFFFFFCCVCCHHNHHCSCCYRRVRQSHSSTTTLTTLLLLLLLLQRAAAAALLLLLIIIIVFYYFFRKRKKLLRLLFFFFFSSSSSSLLSSTTTTTIVIIVTDTTTTTTTSLPPLPTTTTTLLLLL | {
"seq0": "NNTESYLVMQQEELHFSFCHCRSTLLALIFRLFSSTITTLTL",
"seq1": "NNSDGYLMLQQEENYLKFCHSRHTLLALIYKLFSLTVDTPTL",
"seq2": "NNSEGYLMLQQSERHFKFVNCVSLLLALIYRRFSLTITTPTL",
"seq3": "NNTEGYLMLQQEENYFSFCHCRSTLQALIFKLFSSTITTLTL",
"seq4": "NNTDGYLMLQQEENHFSFCHYQTTLRALVFKLFSSTVTSPTL"
} |
KKKKKKKKKKTTTTSLLILLRRRRRVVVIVNNNNNMMIMIAASAAIIIIIAAAAAAEEEKGSSSSEEEEEIVEVAPPSSSEEDEQEDKDKWWWWWEEEEEDSGGGDRRRRDDDDDIIIIIKEEEENNNNQRRQRPKKRNKTTRTTRRRRRLLLLLLLLLLTTTTTPPPPPKNQNQSVHSANNFNFQQQQQQQEHERKRRRATTVTATNNN | {
"seq0": "KKTLRVNMAIAAGEIPEEWEDDDIKNRKTRLLTPKSNQQRAA",
"seq1": "KKTLRVNMAIAESEVPEDWESRDIENRKTRLLTPNVNQQKTT",
"seq2": "KKTIRVNISIAESEESDKWEGRDIENQRRRLLTPQHFQERTN",
"seq3": "KKTLRINMAIAESEVSEDWEGRDIENRNTRLLTPNSNQHRVN",
"seq4": "KKSLRVNIAIAKSEASQKWEGRDIEQPKTRLLTPQAFQERTN"
} |
GGGGGYYYYYFLLLLS-SSSL-LLLR-RRRYYYYYKKKKKIIIIVKKKPKKKKKKKRKRRVVVAVAAAAATTTTTE-PEELIVVISSSSSDEEEEAGAAPEEDEEHQQHQAAAPAVCVVVVVVVVAAAAATF-FFLLLLLKKKKKVVVVVPPQPPPPPPP | {
"seq0": "GYFSLRYKIKKKVATELSDAEHAVVATLKVPP",
"seq1": "GYLYKIKKRVATISEGEQACVAFLKVPP",
"seq2": "GYLSLRYKIKKKVATPVSEADQAVVALKVQP",
"seq3": "GYLSLRYKIPKRAATEVSEAEHPVVAFLKVPP",
"seq4": "GYLSLRYKVKKRVATEISEPEQAVVAFLKVPP"
} |
IMIIIRRRRRIIIIIRRRRRKKKKPGGGGDFFFFIVVVVVLLLLVEAEEEIIIVIRRRRKTAVKAGGGGGVVVV-GGGG-MVMM-TTTT-FYFF-FFFFFQQQQQASSASCASCNDDDDDP-PPPTCCTCEEEEDEEEEENNNQNRRRRRLLLLMIVVVISSSSN | {
"seq0": "IRIRKGFVLEIRTGVGMTFFQACDPTEENRLIS",
"seq1": "MRIRKGFVLAIRAGVGVTYFQSADCEENRLVS",
"seq2": "IRIRKGFVLEIRVGVGMTFFQSSDPCEENRLVS",
"seq3": "IRIRKGFVLEVRKGVGMTFFQACDPTEEQRLVS",
"seq4": "IRIRPDIVVEIKAGFQSNDPCDENRMIN"
} |
DDDDDHHHNHQQQSQIIAIVIVVVI----DGGGGDFGYGFIIVVIRRRRRLLLLIRRNRRFFFFFLLLLLLLLLLVVIVVRAAAADDDDDRERRRLVVVVEETEEAARAAEEEEEHYLYYVVKVVDDDDDLLLLL--K--TTMTTRRNRRKKKKKRRERR---V----V----A----I----Q----Q----Y----I----E----Y----V----A----Q----A----T----K----E----I----I-QQHQQGSGGGTETSTRKRKRLLLLL | {
"seq0": "DHQIIGFIRLRFLLVRDRLEAEHVDLTRKRQGTRL",
"seq1": "DHQIVGGIRLRFLLVADEVEAEYVDLTRKRQSEKL",
"seq2": "DHQAVGYVRLNFLLIADRVTRELKDLKMNKEHGTRL",
"seq3": "DNSIVGGVRLRFLLVADRVEAEYVDLTRKRVVAIQQYIEYVAQATKEIIQGSKL",
"seq4": "DHQVIDDFIRIRFLLVADRVEAEYVDLTRKRQGTRL"
} |
IIIVFGNAGGPPPPPEEEEEGGGGGDDDDDLLLLLTTTTNSSSGAAAAAATTTTTIIILIR-R--E-E--L-L--F-F--A-S--K-Q--A-A--E-E--L-L--S-A--D-D--Q-Q--D-D--S-S--L-L--T-T--V-V--T-T--G-G--G-G---R-RR-G-GG-A-SA | {
"seq0": "IGPEGDLTSATIRELFAKAELSDQDSLTVTGG",
"seq1": "INPEGDLTSATIRGA",
"seq2": "IAPEGDLTSATIRELFSQAELADQDSLTVTGG",
"seq3": "VGPEGDLTGATLRGS",
"seq4": "FGPEGDLNAATIRGA"
} |
GGGGTFFFF-QQQQ-VVVV-YYYY-LLLL-GGGG-AAAA---L----K----H----R----D----D----V----F----D----L----E----D----D----V----E----F----S----Q----R----N----F--DDDD-SYYS-TIVT-VVVV-VVVV-IIII-KQEE-TTTT-TTTT-KKQK-LLLL-HHHH-LLLL-TITTTAAAAALLLLLGGGGGDDDDELIILVGGGGGKKKKKLYLLLLVVLLKKKKKDDDDDTSSTSFFFFW | {
"seq0": "GFQVYLGADSTVVIKTTKLHLTALGDLGKLLKDTF",
"seq1": "GFQVYLGADYIVVIQTTKLHLIALGDIGKYVKDSF",
"seq2": "GFQVYLGALKHRDDVFDLEDDVEFSQRNFDYVVVIETTQLHLTALGDIGKLVKDSF",
"seq3": "GFQVYLGADSTVVIETTKLHLTALGDLGKLLKDTF",
"seq4": "TTALGEVGKLLKDSW"
} |
WWWWWFFFFFVLVVVGGGGG-TT--DDDDDFFFFFEEEEEIIIIILRRRRNSDNNAAAAAGGGGGEDQEEYYYYYKHHKKVVVVVDDDDD-WWW-KTKKKEGDEEFMMIFLLLLIDEERDAGGGAAAAAAQQQQQPPPPPSSAS-DEDD-KKKK-GGGG-DAAA-DDDD-DNDD-LLLL- | {
"seq0": "WFVGDFEILNAGEYKVDKEFLDAAQPSDKGDDDL",
"seq1": "WFLGTDFEIRSAGDYHVDWTGMLEGAQPSEKGADNL",
"seq2": "WFVGTDFEIRDAGQYHVDWKDMLEGAQPADKGADDL",
"seq3": "WFVGDFEIRNAGEYKVDWKEILRGAQPSDKGADDL",
"seq4": "WFVGDFEIRNAGEYKVDKEFIDAAQP"
} |
NNNNNAAAAAKTTTTLLMLLRRRRRIIVIINNNNNIIIIIIIIFFFFFFFFHFHHSSSSSKKKEKKVAVVYYYFFSEEKKRRRRRDDDDDRSRASLLLLLKREKKRRRRR-Y-HH-G-GG-D-DD-M-ND-Y-MY-V-VV-S-TT-I-LL-N-NN-T-TT-A-AA-S-GG-E-EE | {
"seq0": "NAKLRINIIFFSKKYSRDRLKR",
"seq1": "NATLRINIIFHSKVYERDSLRRYGDMYVSINTASE",
"seq2": "NATMRVNIIFFSKAYERDRLER",
"seq3": "NATLRINIFFHSEVFKRDALKRHGDNMVTLNTAGE",
"seq4": "NATLRINIFFHSKVFKRDSLKRHGDDYVTLNTAGE"
} |
GGGGGSSSSSVAAMANNNNDDEEDEEEEEQKAAAAAAAAAAAAAAFFFFFDDDDDKKKKKRSRRRDQQQQGGDGGEEEEEIIIIMASSKSQQQQKTTTTTSTITTFLLLFNGGKGTTTATFFFFFPPPPPSAAAAQKKKKYYYYY-PPPPPPPPPFFFFFTTTSTGGGDGVVVVVNDEDDGGGGAYYYYYYYYYYNNNNNKRRKRNNNNN | {
"seq0": "GSVNDEKAAFDKRDGEIAQTSFNTFPSQYPFTGVNGYYNKN",
"seq1": "GSANEEAAAFDKSQGEISQTTLGTFPAKYPPFTGVDGYYNRN",
"seq2": "GSANEEAAAFDKRQDEISQTILGTFPAKYPPFTGVEGYYNRN",
"seq3": "GSMNDEAAAFDKRQGEIKQTTLKAFPAKYPPFSDVDGYYNKN",
"seq4": "GSADEQAAAFDKRQGEMSKTTFGTFPAKYPPFTGVDAYYNRN"
} |
VVVVVIIIILEEEEENDNNNVLVVVKKKKKYYYYHLLLLLTTTTTMIMMMLLLLLRRKD-ISVI-NNNN-LLLL-GGGA-LLLL-AAAA-NNN--EEE-E----L----SAAA-AWWW-WAAS-AGGG-GLLL-LVII-VQQE-QTIT-IKKK-SNNN-NLLL-LHNN-N----Y----L----P----C----GVIV-ILLLLLKTKKKSSSSSGSGGGPPPPPLLLMLEKEEESSSSSLLLLL | {
"seq0": "VIENVKYLTMLRINLGLANEAWAGLVQTKNLHVLKSGPLESL",
"seq1": "VIEDLKYLTILRSNLGLANEAWAGLIQIKNLNILTSSPLKSL",
"seq2": "VIENVKYLTMLKVNLGLANEAWSGLIETKNLNVLKSGPLESL",
"seq3": "VIENVKYLTMLDINLALALKSGPMESL",
"seq4": "VLENVKHLTMLELSAWAGLVQISNLNYLPCGILKSGPLESL"
} |
HHRQHAQEEQHMMMMPPPPPIIIIIIFFTFAAAAALVVVVPPPPPQEKEEAAAAPFFIFYQQQQQVIIIIAAAAVESSESDDDDDGSGGGPPPPPAAAAANSSSSHHHHHNRHARVIVVVVVVVVEEEEELLLLLVMVVMHQHHQPPPPP-AAAATTTTTQHHHHDDDDDTPTTTPPPPPIIIIIYKMYKSASNSSFTTI | {
"seq0": "HAHPIIALPQAFQVAEDGPANHNVVELVHPTQDTPIYSS",
"seq1": "HQMPIFAVPEAFQIASDSPASHRIVELMQPATHDPPIKAF",
"seq2": "REMPIFAVPKAIQIASDGPASHHVVELVHPATHDTPIMST",
"seq3": "QEMPITAVPEAFQIAEDGPASHAVVELVHPATHDTPIYNT",
"seq4": "HQMPIFAVPEPYQIVSDGPASHRVVELMQPATHDTPIKSI"
} |
PPPPPSSSSTNQNQQKKKKKT-V-LVVVVVNDDDDEEEEDSSDSSTIIIIGGGGQIIIIIFFFFFRGGGGNNNGNLLLLLHMLLLLLLMFAMAAATTMTTEDEDEKRRRA-S----L----D----K----I----I----V----E----Y----K----Y----R----E----A----T---DDSDDPPPPPLILLVACLVMWWWWWENEEEEEEESLLLLLTTTTVDDDDDVVLVVEEEDELLLLLE-EEGR-RRRRRRRLDEEEEQQQQQGGGGGHHHHH | {
"seq0": "PSNKTVNESTGIFRNLHLATEKDPLAWEELTDVELERRDQGH",
"seq1": "PSQKVDESIGIFGNLMLMTDRSLDKIIVEYKYREATDPICWNELTDVELREQGH",
"seq2": "PSNKVVDEDIGIFGNLLLAMERSPLLWEELTDLELERREQGH",
"seq3": "PSQKVDESIGIFGGLLMATDRDPLVWEELTDVDLERREQGH",
"seq4": "PTQKLVDDSIQIFGNLLFATEADPVMWESLVDVELGRLEQGH"
} |
LLRLLYYYYEIVVVVAEAAAGGGGGNNNNNLLLLLNNEENILLLLRRRRRDDSQSTNGGNPPDPPKQQQQGGAAAMMMMYHH-DHSTAATEEEEVTTTTTEEKEESSHHSVILLLRRRRRDDEDDIVVVVGGGGGVVVVVRRKKKNHEEEWWWWWLILIITNNNEASSSS | {
"seq0": "LYIAGNLNIRDTPKGMHSETESVRDIGVRNWLTA",
"seq1": "LYVEGNLNLRDNPQGMHTETESIRDVGVRHWINS",
"seq2": "RYVAGNLELRSGDQAMAETKHLREVGVKEWLNS",
"seq3": "LYVAGNLELRQGPQAMDAETEHLRDVGVKEWINS",
"seq4": "LEVAGNLNLRSNPQAYHTVTESLRDVGVKEWIES"
} |
LLILIFFFFFKKKKKLL-LLII-IILLLLLQSQQQYYFYFLLVLVKKKKKNNKNNEQQQQQEQQQGGGGGQQMQQEEQEEPPPPPPDNHNRRRRRIIIIIYYYYYEEEEENNKNKKKRRRGGGGGAAAATLLLLLRRKRRRRRRRNNDNNGGGGGK----R----Q----P----R----E----EEKEEGGSGSTTTTTKKKKKLLLLLQQQQQLLGGGIVSAALLIVIEEEEEPPAPS | {
"seq0": "LFKLILQYLKNEQGQEPPRIYENKGALRRNGKRQPREEGTKLQLILEP",
"seq1": "LFKLILSYLKNQEGQEPDRIYENKGALRRNGEGTKLQLVLEP",
"seq2": "IFKLQFVKKQQGMQPNRIYEKRGALKRDGKSTKLQGSIEA",
"seq3": "LFKLILQYLKNQQGQEPHRIYENRGALRRNGEGTKLQGAVEP",
"seq4": "IFKLILQFVKNQQGQEPNRIYEKRGTLRRNGESTKLQGAIES"
} |
NHHNDAAAAAKKKKKNNNNNVVVKKEEEEEPPPPPWWWSSQQQQQKKNNNIIIIIR----Y----SSSNNTTTTTHHVVVMTTTTEEEEEQQRQQEEEEQSTGSSGGGGGDD-KKEEEEEAVAAAEEEEEIIIMMTSTTTVV---AA---QQAQQIIIIIPPAPPGGGGGII---RRRRREHNHHEEEEEGGGGGEEEEELLFFFTTTET | {
"seq0": "NAKNVEPWQKIRYSTHMEQESGDEAEITVAQIPGIREEGELT",
"seq1": "HAKNVEPWQKISTHTEQETGDEVEISVAQIPGIRHEGELT",
"seq2": "HAKNVEPWQNISTVTEREGGEAEITAIAGRNEGEFT",
"seq3": "NAKNKEPSQNINTVTEQESGKEAEMTQIPGRHEGEFE",
"seq4": "DAKNKEPSQNINTVTEQQSGKEAEMTQIPGRHEGEFT"
} |
KSKKKTTTTTVVVVVAAGGATTTTTTTTTTLLIILLLLLLHHAHWASS-SNTTTTRRRRRSGGGGDDDDDYFYYFLLLLLGLLILFLFFLWWWWWIMMMMS-TS-W-WW-V-VI-V-PP-S-TT-G-GG-K-SS-L-VV-CRRRRAAATAPPPPPKKKKKILLLVLLLLLVVVVVPEEEEKKKK-WWWW-CCCCAKRKKKLVLLVSTSAAEESEEEEEREILIIL | {
"seq0": "KTVATTLLHANRSDYLGFWISWVVSGKLCAPKILVPKWCKLSEEI",
"seq1": "STVATTLLHSTRGDFLLLWMRAPKLLVEKWCRVTEEL",
"seq2": "KTVGTTILASTRGDYLLFWMTWVPTGSVRAPKLLVEKWCKLSSEI",
"seq3": "KTVGTTILHTRGDYLIFWMSWIPTGSVRTPKLLVEKWCKLAERI",
"seq4": "KTVATTLLWSTRGDFLLLWMRAPKVLVEAKVAEEL"
} |
VVVVAEEQEEEEDEELLLLMSSSSLYYYYYLLVFLTTSILMMMMKAVVAAEEEQNNNNHDAYYAASESNKVIVVVLLLQGEEEEQLLLLLMLMMTKK-KNLL-FYRR-RRII-IILL-LLYF-YYRRRRRRRRRRNNNNNDDDDD-NN--RRRRRLLLLLTTTTVEEEEEIVVIV | {
"seq0": "VEELSYLTMAENASVLELMKLRILYRRNDRLTEI",
"seq1": "VEELSYLTMVENYEILELLKLRILFRRNDNRLTEV",
"seq2": "VQDLSYVSMVENYSVLELMRRNDNRLTEV",
"seq3": "VEELSYFIMAQHANVQELMKFRILYRRNDRLTEI",
"seq4": "AEEMLYLLKANDAKVGQLTNYRILYRRNDRLVEV"
} |
SSQSRIVIIIQKPKPVVVVVAAAAAEEKEKEEEEEFFFFFGDGDSKKKKKIIIIVFFFFFS-SSSV--VSA-AA-N-NS-E-EDES-GSGQ-QQSM-IILK-QQQD-DDDG-GGGT-TTTQ-EQEE-EEQA-AAFFFFFVVVVVAEEEEQHHHHHIIIIITTTTTDDNNDGGGGGETEEEVVVAVAASSSDDDDDIIVIVAAAAAGDGGGRRRRKVVVIV | {
"seq0": "SIQVAEEFGKIFSVANESQMKDGTQEAFVEHITDGEVADIAGRV",
"seq1": "SVKVAEEFDKIFFVEHITDGTVADIADRV",
"seq2": "QIPVAKEFGKIFSANEGQIQDGTEEAFVEHITNGEVSDVAGRV",
"seq3": "SIKVAEEFDKIFSVASDSQIQDGTQEAFVEHITNGEASDIAGRI",
"seq4": "RIPVAKEFSKVFSSEGSLQDGTEQFVAQHITDGEVSDVAGKV"
} |
QQQQQVVVVVPPPPPTTTTTEKKKKAAAAANNNNNGQLLQTTTTTSANNSAAAAALLLLLVVMMVAAAAAYYYYYQQQQQKRSRDAAAAAPPPPPPVIIIDTDADWWWWWKKKKKFFFFF--QK---II---DD---TT---GS---FF---EE---KK-NNNNNQQQQQWWFYWASNNSQQQKQNRESREEEQELIIIIPPPPPWYYFYPPPPPYYYYYAGAAG | {
"seq0": "QVPTEANGTSALVAYQKAPPDWKFNQWAQNELPWPYA",
"seq1": "QVPTKANQTAALVAYQRAPVTWKFNQWSQREIPYPYG",
"seq2": "QVPTKANLTNALMAYQSAPIDWKFQIDTGFEKNQFNQEEIPYPYA",
"seq3": "QVPTKANLTNALMAYQRAPIAWKFKIDTSFEKNQYNKSQIPFPYA",
"seq4": "QVPTKANQTSALVAYQDAPIDWKFNQWSQREIPYPYG"
} |
TTTTTVVIIIYYVYVLLLLLPPPPPLLLLLATATAVVVVVLLLLLSANANQQRNRGGGGGGAPGPSSGAGEEEEESSASALLILIFFFFFAAAAAAAPAGEEEEERRRRRPPPPPIIVLVYNYHYFMFRFEDDDDRQQKRWYWWWYYYYYLLLMLQEEEESSSSSGGGTGKRKLKIYIIIEPEQETTSTS | {
"seq0": "TVYLPLAVLSQGGSESLFAAERPIYFERWYLQSGKIET",
"seq1": "TVYLPLTVLAQGASESLFAAERPINMDQYYLESGRYPT",
"seq2": "TIVLPLAVLNRGPGEAIFAPERPVYFDQWYLESGKIES",
"seq3": "TIYLPLTVLANGGAESLFAAERPLHRDKWYMESTLIQT",
"seq4": "TIVLPLAVLNRGPGEAIFAGERPVYFDRWYLESGKIES"
} |
LLLLLSSSTSAAAAADDDDDYFFFYVGGGIHRHHHTTTTTFCCCFMVVVIYYYYYLLLLLQQQQQVTTTVIVII-IIII-TDDD-LLLLLVVVVVRRRRRRRQQREEEEEPPPPPVVAAVRRRRRYYYYY----QSSSSSGGRKGQQQQQRKRRRLLLLLKKKKKGGGGGGGGDG | {
"seq0": "LSADYVHTFMYLQVIITLVRREPVRYSGQRLKGG",
"seq1": "LSADFGRTCVYLQTVIDLVRREPVRYSGQKLKGG",
"seq2": "LSADFGHTCVYLQTIIDLVRQEPARYSRQRLKGG",
"seq3": "LTADFGHTCVYLQTIIDLVRQEPARYSKQRLKGD",
"seq4": "LSADYIHTFIYLQVLVRREPVRYQSGQRLKGG"
} |
TTTTTSTTSSGGGGGPPPPPKEKKKVTVVVVVVVILMMLLVVVVVAMMMSIVVVIRRRRRECAEEQEDEQPPPPPEEEEEKKTKKFFFFFHNHQHPPPPPGGGGGI-TTIF-FYFM-KDML-ALLW-WWWE-DDDK-KKKL-LILF-FFFS-SSAEEEEELLLLLQQQQQ | {
"seq0": "TSGPKVVLVAIREQPEKFHPGIFMLWEKLFSELQ",
"seq1": "TTGPETVMVMVRCEPEKFNPGELQ",
"seq2": "TTGPKVVMVMVRADPETFHPGTFKAWDKLFSELQ",
"seq3": "TSGPKVVLVMVREEPEKFQPGTYDLWDKIFSELQ",
"seq4": "TSGPKVILVSIREQPEKFHPGIFMLWDKLFAELQ"
} |
DDDDDTSTSTRVRRRKKREKYYYYYKEKEKDEDEDEEEEEKKRKRVIVVVTQAKADDDDDSSSSSFLLILTTTTTVIIIIEDDDDSSSDIVVEVERRRRREEEEERRRRRFLLFLHHAHPPPPPPAASTSPPPPPHHHHHGGGGGNQMNNVVIVIVVVVISSASSMIMLM | {
"seq0": "DTRKYKDEKVTDSFTVESVRERFHPAPHGNVVSM",
"seq1": "DSVKYEEEKIQDSLTIDSVRERLHPAPHGQVVSI",
"seq2": "DTRRYKDERVADSLTIDSERERLAPSPHGMIVAM",
"seq3": "DSREYEEEKVKDSITIDDVRERFHPTPHGNVVSL",
"seq4": "DTRKYKDERVADSLTIDIERERLPPSPHGNIISM"
} |
YYYHYFFFFFPSPSPQQQQQMRMMMLYLLLRRRRRKKKKKGGGGGKRKKKPPPPPRRKRKNINNNIIIIISSSASYLYYYQQQQQEDKEERRRRRDDDDDVVIVFDDDDDTTNTSMMMLMLSIIILLLLLNYNNEQMQMQMMMMMLLILIKKKKKGGGGGDDNDNEEEETTEQEK | {
"seq0": "YFPQMLRKGKPRNISYQERDVDTMLLNQMLKGDET",
"seq1": "YFSQRYRKGRPRIISLQDRDVDTMSLYMMLKGDEE",
"seq2": "YFPQMLRKGKPKNISYQKRDIDNMILNQMIKGNEQ",
"seq3": "HFSQMLRKGKPRNIAYQERDVDTLILNMMLKGDEE",
"seq4": "YFPQMLRKGKPKNISYQERDFDSMILEQMIKGNTK"
} |
NNKKNACAACKDEEDQSSSSFFFFFSQCSQVVVVVDDDDDHQQQQEAEEAPPPPPVVVVVRHHHQILIILMALLSRRRRRQQQQAAGGGGIVVIIMMMMMWWWWMDEEEELLLLLFYDYYHRKNRFLLLLESEEDEEEEDNNNNNTKTATAAAAGNNNNNLLLLLGGGGGYFFFFAAAAAQKQQK | {
"seq0": "NAKQFSVDHEPVRIMRQAIMWDLFHFEENTANLGYAQ",
"seq1": "NCDSFQVDQAPVHLARQGVMWELYRLSENKANLGFAK",
"seq2": "KAESFCVDQEPVHILRQGVMWELDKLEENTANLGFAQ",
"seq3": "KAESFSVDQEPVHILRQGIMWELYNLEENAANLGFAQ",
"seq4": "NCDSFQVDQAPVQLSRAGIMMELYRLDDNTGNLGFAK"
} |
KKKKKLLFLLEEEEEDDDDDRQRQRESESEMMAMMRRRRREEDEEAAAAAAAVAARRRRTYYHYYNKNKRLLLLLCCCCCWWLWWFFFFFYVYVYA-A-AD-D-DR---RK---TR---RL-L-LV-V-VV-V-VS-A-AI-L-IK-K-KE-E-ETRKTTFWWWWSTGTSTTTTTKLQLLIVAVIGGKGGDDDDDTTTTTIIILVAAAAAEEEEEDNNDDLILILEEQEE | {
"seq0": "KLEDREMREAARYNLCWFYADRKRLVVSIKETFSTKIGDTIAEDLE",
"seq1": "KLEDQSMREAARYKLCWFVRWTTLVGDTIAENIE",
"seq2": "KFEDREARDAVRHNLCLFYADLVVALKEKWGTQAKDTIAENLQ",
"seq3": "KLEDQSMREAARYKLCWFVTWTTLVGDTLAEDIE",
"seq4": "KLEDREMREAATYRLCWFYADRTRLVVAIKETWSTLIGDTVAEDLE"
} |
YYYYFMIMIILLLLLLLLGAPPPPRKKDKKYYFYYNNNNNWWWWYKKKKKFLLLLNKNNNYDSEDQQQQQLLLLVLLLLL--V----D----V--TTTPSAAAAGEEEEEQQQQQKKKKKGGGGGYYYYYDDETSPPPPPDQNQQEEEEDHHHHHDDDDDLLLLLYYYYYHHIHQKKKKKSTHTTLLLVVEEEEEPPPPPCCCTT | {
"seq0": "YMLLPKYNWKFNYQLLTAEQKGYDPDEHDLYHKSLEPC",
"seq1": "YILLPKYNWKLKDQLLTAEQKGYDPQEHDLYHKTLEPC",
"seq2": "YMLLPDFNWKLNSQLLVDVTAEQKGYEPNEHDLYIKHLEPC",
"seq3": "YILGPKYNWKLNEQLLPAEQKGYTPQEHDLYHKTVEPT",
"seq4": "FILARKYNYKLNDQVLSGEQKGYSPQDHDLYQKTVEPT"
} |
Multiple Sequence Alignment as a Sequence-to-Sequence Learning Problem
Abstract:
The sequence alignment problem is one of the most fundamental problems in bioinformatics and a plethora of methods were devised to tackle it. Here we introduce BetaAlign, a methodology for aligning sequences using an NLP approach. BetaAlign accounts for the possible variability of the evolutionary process among different datasets by using an ensemble of transformers, each trained on millions of samples generated from a different evolutionary model. Our approach leads to alignment accuracy that is similar and often better than commonly used methods, such as MAFFT, DIALIGN, ClustalW, T-Coffee, PRANK, and MUSCLE.
An illustration of aligning sequences with sequence-to-sequence learning. (a) Consider two input sequences "AAG" and "ACGG". (b) The result of encoding the unaligned sequences into the source language (Concat representation). (c) The sentence from the source language is translated to the target language via a transformer model. (d) The translated sentence in the target language (Spaces representation). (e) The resulting alignment, decoded from the translated sentence, in which "AA-G" is aligned to "ACGG". The transformer architecture illustration is adapted from (Vaswani et al., 2017).
Data:
We used SpartaABC (Loewenthal et al., 2021) to generate millions of true alignments. SpartaABC requires the following input: (1) a rooted phylogenetic tree, which includes a topology and branch lengths; (2) a substitution model (amino acids or nucleotides); (3) root sequence length; (4) the indel model parameters, which include: insertion rate (R_I), deletion rate (R_D), a parameter for the insertion Zipfian distribution (A_I), and a parameter for the deletion Zipfian distribution (A_D). MSAs were simulated along random phylogenetic tree topologies generated using the program ETE version 3.0 (Huerta-Cepas et al., 2016) with default parameters.
We generated 1,495,000, 2,000 and 3,000, protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range (0.5,1.0). Next, the sequences were generated using SpartaABC with the following parameters: R_I,R_D \in (0.0,0.05), A_I, A_D \in (1.01,2.0). The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range [32,44]. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides (0.37, 0.166, 0.307, 0.158), in the order "T", "C", "A" and "G"; (2) with the substitutions rate (0.444, 0.0843, 0.116, 0.107, 0.00027), in the order "a", "b", "c", "d", and "e" for the substitution matrix.
Example:
The following example correspond for the illustrated MSA in the figure above:
{"MSA": "AAAC-GGG", "unaligned_seqs": {"seq0": "AAG", "seq1": "ACGG"}}
APA
Dotan, E., Belinkov, Y., Avram, O., Wygoda, E., Ecker, N., Alburquerque, M., Keren, O., Loewenthal, G., & Pupko T. (2023). Multiple sequence alignment as a sequence-to-sequence learning problem. The Eleventh International Conference on Learning Representations (ICLR 2023).
BibTeX
@article{Dotan_multiple_2023,
author = {Dotan, Edo and Belinkov, Yonatan and Avram, Oren and Wygoda, Elya and Ecker, Noa and Alburquerque, Michael and Keren, Omri and Loewenthal, Gil and Pupko, Tal},
month = aug,
title = {{Multiple sequence alignment as a sequence-to-sequence learning problem}},
year = {2023}
}
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