MSA
stringlengths 0
1.02k
| unaligned_seqs
dict |
---|---|
LLLLEEEEAAAAMMMMVVVVEEEDIVVVLLLLFFFFRRRRSSSSRKRKEEDDLLLLKKKKGGGGDDDDAAAAEAAAPPPPGGGGNNNNLLLLGGGGVVVVCNCNMMLPNNNSGGGGLILIYYFHEEEEMTILDRKRSSSDFFFFPPPL | {
"seq0": "LEAMVEILFRSRELKGDAEPGNLGVCMNGLYEMDSFP",
"seq1": "LEAMVEVLFRSKELKGDAAPGNLGVNMNGIYETRSFP",
"seq2": "LEAMVEVLFRSRDLKGDAAPGNLGVCLNGLFEIKSFP",
"seq3": "LEAMVDVLFRSKDLKGDAAPGNLGVNPSGIHELRDFL"
} |
PPPPTSSNSSSSKKKKQQQQSSGLDDDDDDDDKKKKQEQQITIIAAAAMMMMVVVASAAAAGGAEEEESSSS---V---Y---R---A---A---A---W---H---Q---N---Y---W---L---G---E---E---L---C---A-M---L---E---R---R---S---I---E---I---I---V---K---M---I---G---Q---A---C---S---H---E---Y---I---A---L---I---D---G---R---A---E---G---L---V---T---L---L--TTTTTTTALLLFIIIIFFFFVIVVKKRKVLVLCCFCCLCLNCNNFFILESEEQQQQRPRRMIMMSSSSGGGGMFFF | {
"seq0": "PTSKQSDDKQIAMVSAESTTLIFVKVCCNFEQRMSGM",
"seq1": "PSSKQSDDKETAMVAGESMLERRSIEIIVKMIGQACSHEYIALIDGRAEGLVTLLTTLIFIKLCLCFSQPISGF",
"seq2": "PSSKQGDDKQIAMVAGESTTLIFVRVFCNIEQRMSGF",
"seq3": "PNSKQLDDKQIAMAAAESVYRAAAWHQNYWLGEELCATAFIFVKLCLNLEQRMSGF"
} |
KKKKGTVGEEEEGGGGAAAAGGDGDSTDLLLLTTITKKKKDDDDILVICCCCVVGVQRRQLLVLATTTAASAGGGGNNANQPYQEQQESQQQLLLLAAAARVVCTSASAAAAFQQQSSSSHHHHVVVVQLLLWWWWK--- | {
"seq0": "KGEGAGDLTKDICVQLAAGNQESLARTAFSHVQWK",
"seq1": "KTEGAGSLTKDLCVRLTAGNPQQLAVSAQSHVLW",
"seq2": "KVEGADTLIKDVCGRVTSGAYQQLAVAAQSHVLW",
"seq3": "KGEGAGDLTKDICVQLTAGNQEQLACSAQSHVLW"
} |
EEEEFFFFVAVAPPPPYYYYGGGGLILMIIIIQSSSEEEEAVAVSTSTYFYYEEEEVLILEEEQKKKKSSSSGGGGKQKQRKRKFLFLEEEENDNDRRKRIVIVLLLQEEEERERRVTVTGGGGGGGGWWWWDDDDIIIIVIIISSSSDDDDKKKKNNNNV-V-F-F- | {
"seq0": "EFVPYGLIQEASYEVEKSGKRFENRILERVGGWDIVSDKNVF",
"seq1": "EFAPYGIISEVTFELEKSGQKLEDRVLEETGGWDIISDKN",
"seq2": "EFVPYGLISEASYEIEKSGKRFENKILERVGGWDIISDKNVF",
"seq3": "EFAPYGMISEVTYELQKSGQKLEDRVQERTGGWDIISDKN"
} |
MMYMQQKQFLFLEEEETTTTYYYYAAAMHHHHAAASIIIIIIIIVIVIKRSKAASATRRRLLLLTTTISSSSNNNDLLVLAARASSSRESKEFFMFRRSRIIVIIIIIASSGTSTSSSSASSSARRRRIIIIIVVVRRRRSSQS---H---E---QSSSVSSTT | {
"seq0": "MQFETYAHAIIVKATLTSNLASEFRIIATSSRIIRSSS",
"seq1": "MQLETYAHAIIIRARLTSNLASSFRIISSSSRIVRSSS",
"seq2": "YKFETYAHAIIVSSRLTSNVRSKMSVISTSSRIVRQST",
"seq3": "MQLETYMHSIIIKARLISDLAREFRIIGSAARIVRSHEQVT"
} |
NDDDIIIIRQRQTAAAIIIIFLFLGGGGWWWWL-L-K-K-N-N-HIHIQEQYRRSRHQHQQQHNSNSNMVLVKKKKMMMGVIIILLLLSSNS-D-DIIIIMMMMYYYYVAAALLLLVAVVQHEHDDDDDEDESGAGILALIIIIGGGGSSNSQQQQNRNR | {
"seq0": "NIRTIFGWLKNHQRHQSMKMVLSIMYVLVQDDSIIGSQN",
"seq1": "DIQAILGWIERQQNVKMILSDIMYALAHDEGLIGSQR",
"seq2": "DIRAIFGWLKNHQSHHSLKMILNIMYALVEDDAAIGNQN",
"seq3": "DIQAILGWIYRQNNVKGILSDIMYALVHDEGLIGSQR"
} |
SSSSTKLICCCCAAMADDDDAAKKGGGGFFYFMILLEEKKGGGGIITMHHHHAAALTTTV--C-FFFFQQQVYYYYKKKK---V---EDDDDKKKKQQKKEEEEMLLLLRRKNNNNLLLLSSSSKKKAGGGGLLLLPPPPRRRRNNNNLLLVSSSAGGGGFFFFIIVI | {
"seq0": "STCADAGFMEGIHATFQYKDKQEMLNLSKGLPRNLSGFI",
"seq1": "SKCADAGFIEGIHATFQYKDKQELRNLSKGLPRNLSGFI",
"seq2": "SLCMDKGYLKGTHATCFQYKDKKELRNLSKGLPRNLSGFV",
"seq3": "SICADKGFLKGMHLVFVYKVEDKKELKNLSAGLPRNVAGFI"
} |
AAAASSSSSSSLGGGGVVVVDDDDLLLLGGG-IIIIQQQQDDDERRRRYYYYTSASQQQQPTRSYYYYSSSSMMLMAAAFNNSNFFFFKKKKQQGKDDDDPPPPYYYYEEEELIIIAAAKLIQLIII-AAA-FFF-IIA-PPP-EEE-KKK-CCL-KTKK | {
"seq0": "ASSGVDLGIQDRYTQPYSMANFKQDPYELALIAFIPEKCK",
"seq1": "ASSGVDLGIQDRYSQTYSMANFKQDPYEIAIIAFIPEKCT",
"seq2": "ASSGVDLGIQDRYAQRYSLASFKGDPYEIAQIAFAPEKLK",
"seq3": "ASLGVDLIQERYSQSYSMFNFKKDPYEIKLK"
} |
DDDDVIVIPPPPFFFFNKNKTTVT---Q---L---A---LLIILVIIIEEEECCCNSNNNAAAATTTTRRRRLMLLRHRHSSSSIIMILMLMNNNNIIILATVTLVLLGGGNLHLYAAAARGGGAAAAFSFF--E-PPPPSSSSGGGTSSSDIVVVGGGGRRRKSSQSDSSMDNNN-A---D---V---A---I---E---S---L---H---E---S---L---Q---E---Y---A---R---N---N---V---E---P---T---A---D---L-- | {
"seq0": "DVPFNTLVECSATRLRSILNIALGLARAFPSGSIGRSDD",
"seq1": "DIPFKTIIECNATRMHSIMNITVGHAGASPSGSVGRSSNADVAIESLHESLQEYARNNVEPTADL",
"seq2": "DVPFNVIIECNATRLRSMLNIVLGLAGAFEPSGSVGRQSN",
"seq3": "DIPFKTQLALLIENNATRLHSIMNLTLNYAGAFPSTDVGKSMN"
} |
DDDDVVVMILLLIIIIQQQQNRNRVVVVCCCCAVAAGGGGKKKKLLLLQQQKEEEETTTTFFFFGGGGRKRRD-DEI-VII-IVF-FFRRRRFFFFKKKKSSSSIIIIQQQQTTTTMMMMILIFDDDDYFYFAART | {
"seq0": "DVIIQNVCAGKLQETFGRDIIFRFKSIQTMIDYA",
"seq1": "DVLIQRVCVGKLQETFGKRFKSIQTMLDFA",
"seq2": "DVLIQNVCAGKLQETFGRDVIFRFKSIQTMIDYR",
"seq3": "DMLIQRVCAGKLKETFGREIVFRFKSIQTMFDFT"
} |
LLLLLHLLNNNNLLLLEEEETTITEEEELLLLTTTTVFVVRRRRIFIIVVVVTTTAIFFFNVSSKKRKIVAVKKKKRQRRAAAANNNNLLLMFFFFGGGGTKTTGEEENVNNRRGRTTTTIIAAEVKK-E---I-- | {
"seq0": "LLNLETELTVRIVTINKIKRANLFGTGNRTIE",
"seq1": "LHNLETELTFRFVTFVKVKQANLFGKEVRTIVEI",
"seq2": "LLNLEIELTVRIVTFSRAKRANLFGTENGTAK",
"seq3": "LLNLETELTVRIVAFSKVKRANMFGTENRTAK"
} |
TVIIDSDSFFFFYWYYAAAADDDDLLLFAAAAALLLCCCCKKKKFFFFIYVIIPVPAAAARRRRPPFPIKIIAAAARRRRTTTVQQQQGGGGVVVVAAAAASASIVIINNENNNNNAAAAPPIPIVVVTQQQGEEETVVV | {
"seq0": "TDFYADLAACKFIIARPIARTQGVAAINNAPITGT",
"seq1": "VSFWADLALCKFYPARPKARTQGVASVNNAPVQEV",
"seq2": "IDFYADLALCKFVVARFIARTQGVAAIENAIVQEV",
"seq3": "ISFYADFALCKFIPARPIARVQGVASINNAPVQEV"
} |
TTTTVMIVNNDNPPPAMTTTAAAALLLLPPPPLVIISASSDDDDDDGNS--SL--LG--GLLLLIIIITTTTKKTTLLMLDDDDNNNNQQESVVVLDDDDMMIMFFFFIIIINNNNSSSSGGGGVVTVSAAAPPPPTTVTSNNNVVVVIIIIAAAAEENETTTTEEEE | {
"seq0": "TVNPMALPLSDDSLGLITKLDNQVDMFINSGVSPTSVIAETE",
"seq1": "TMNPTALPVADDLITKLDNQVDMFINSGVAPTNVIAETE",
"seq2": "TIDPTALPISDGLITTMDNEVDIFINSGTAPVNVIANTE",
"seq3": "TVNATALPISDNSLGLITTLDNSLDMFINSGVAPTNVIAETE"
} |
LLLLGGGGKKHKPPPPGGGGLVVVDYYRSASTLLILLLLLPPPPIILLFFFFFFFFEEEENNNNRRQQPPPPTTIIQKKKSSSAP-PPC-CCL-LLI-IIIITTGGGGDDQDIIIILWIIIVVVDDDDLHLLDDDD | {
"seq0": "LGKPGLDSLLPIFFENRPTQSPCLIIGDILIDLD",
"seq1": "LGKPGVYALLPIFFENRPTKSIGDIWVDHD",
"seq2": "LGHPGVYSILPLFFENQPIKSPCLITGQIIVDLD",
"seq3": "LGKPGVRTLLPLFFENQPIKAPCLITGDIIVDLD"
} |
TSAT-LL--SS--LL--TT--YY--EE--PP--GA--LL--VV--TT--A---YY--KK--NN--AA--AA--YY--FF--PP--TT--PP--LL--SS--KK--YF--DD--FF--LL--PP-YHHFIVVLWWWWLLLLIIIIAPPAHDHDIIIISSASSSSSAAAARRRRRALRRAAREFHELLLLRRRRLLLLR--RE--DM--MI--MVMMVS---AMMVTTTTSTTSRRRRWWWWQAAKDDDD-HH-GGGGAAAA | {
"seq0": "TYIWLIAHISSARRRELRLREMIVSATSRWQDGA",
"seq1": "SLSLTYEPGLVTAYKNAAYFPTPLSKYDFLPHVWLIPDISSARAAFLRLMMTTRWADHGA",
"seq2": "ALSLTYEPALVTYKNAAYFPTPLSKFDFLPHVWLIPHIASARLAHLRLMMTTRWADHGA",
"seq3": "TFLWLIADISSARRRELRLRDMMVVTSRWKDGA"
} |
VIVVAASATATT--S-EEEEPPPPRRRRVVIVKKKKTVTTTTTNVVVVASACPPPPFFFFEEKESASSDDDDTVTKKKKKGGGGPPPPKKQKRRRRTTTTNNNNLVLVVTATAASASNTSSSTSLLLLVVTVPPPPAGGAD-EDM-MMF-GGI-IISSST | {
"seq0": "VATEPRVKTTVAPFESDTKGPKRTNLVASSLVPADMFIS",
"seq1": "IAAEPRVKVTVSPFEADVKGPKRTNVTANSLVPGS",
"seq2": "VSTSEPRIKTTVAPFKSDTKGPQRTNLASTTLTPGEMGIS",
"seq3": "VATEPRVKTNVCPFESDKKGPKRTNVTASSLVPADMGIT"
} |
AAAADNNNSSSSLLLLILLLASAAAAEAELLEEEEE-CC--KK-NNNNPPPPEEEEIIIIDDDDHEEQQQQNDGGDKKKKFYYFDDDDMMMMVVVMQRRQLLLLYYYYNSNNLLLLEDQEKKKKDDDDENNDGGGGNWHYFFFFNNNN | {
"seq0": "ADSLIAAEENPEIDHQDKFDMVQLYNLEKDEGNFN",
"seq1": "ANSLLSALECKNPEIDEQGKYDMVRLYSLDKDNGWFN",
"seq2": "ANSLLAELECKNPEIDEQGKYDMVRLYNLQKDNGHFN",
"seq3": "ANSLLAAEENPEIDQNDKFDMMQLYNLEKDDGYFN"
} |
KKRKNNNNNQQQAAAKGGGGMLMMEDDDPPPPVITTGGGGSSSSDEEENNNNPPPPLLMMDDDDAAAAYYYYHHHHPMPPPPPPVVVVGGGGGEDDCCCCYYYYNQQQLLLLEEEEATTTLLLLEDDD | {
"seq0": "KNNAGMEPVGSDNPLDAYHPPVGGCYNLEALE",
"seq1": "KNQAGLDPIGSENPLDAYHMPVGECYQLETLD",
"seq2": "RNQAGMDPTGSENPMDAYHPPVGDCYQLETLD",
"seq3": "KNQKGMDPTGSENPMDAYHPPVGDCYQLETLD"
} |
VIIIKTTKEEEERRRRRRRLPVKPYYYYKKKKQKQHIMMIQQQQPPPPQQQQAAASEEEENNNNDDDDLLLLRRRRLLLLASSSVVVVDDSDP--PD--EQWWQLLLLFYFFDDEELLLLVTNTKLLR | {
"seq0": "VKERRPYKQIQPQAENDLRLAVDPDQLFDLVK",
"seq1": "ITERRVYKKMQPQAENDLRLSVDWLYDLTL",
"seq2": "ITERRKYKQMQPQAENDLRLSVSWLFELNL",
"seq3": "IKERLPYKHIQPQSENDLRLSVDPEQLFELTR"
} |
EQEEIIVIRRRRTAVVAAAALLLLLLFLLLILT---L---F---Y---T---AAAALLMLLLLLLLLLDDEEFYFFCCMCHHCCTTTTPPPPQQRQPPEEPPPPIIFIIIIISSSSEEEERRRKEEEEKKKKSSSSTREETSSSVVVV | {
"seq0": "EIRTALLLTLFYTALLLDFCHTPQPPIISEREKSTTV",
"seq1": "QIRAALLLALLLDYCHTPQPPIISEREKSRSV",
"seq2": "EVRVALFIAMLLEFMCTPREPFISEREKSESV",
"seq3": "EIRVALLLALLLEFCCTPQEPIISEKEKSESV"
} |
RRKRSSSSPPPPVVVVDDDDGGGGVVVVVVIVPRHHEEEEDSSSVVVVAAAATNTSLMLLDEDEHHHHYYYY-GGG-VVV-EKQ-EEE-FYI-LLL-KKK-HYH-PPP-NNN-TLT-SSS-AAA-EQQ | {
"seq0": "RSPVDGVVPEDVATLDHY",
"seq1": "RSPVDGVVRESVANMEHYGVEEFLKHPNTSAE",
"seq2": "KSPVDGVIHESVATLDHYGVKEYLKYPNLSAQ",
"seq3": "RSPVDGVVHESVASLEHYGVQEILKHPNTSAQ"
} |
DHDHHHHHLEQQEPEPIMIMTSTSIIIIGGGGFIYIGGGGIIIILILLDDDDLVLVIIITPPPPGGGAFFFFQQQQRKRKTATT-L-FIIIIGGGGVCVCRRRRLQLQNHNHVVVCEEQERFYFDDDDILLLRRRREEEEHYHHYYYYIIIIVSVS | {
"seq0": "DHLEITIGFGILDLIPGFQRTIGVRLNVERDIREHYIV",
"seq1": "HHEPMSIGIGIIDVIPGFQKALIGCRQHVEFDLREYYIS",
"seq2": "DHQEITIGYGILDLIPGFQRTIGVRLNVQYDLREHYIV",
"seq3": "HHQPMSIGIGILDVTPAFQKTFIGCRQHCEFDLREHYIS"
} |
SSFSHHRRQQQKIIVVYYYYLLLLEREEPPPPLQLLGGNNWWWFDDDDEEEEIIIIRRRREEERIVILEEQETTSSAAAAQKKKVVAAYYYLKNNNIFFFYYYLKKKKFLLLPPPPKKKKAATTVVVV | {
"seq0": "SHQIYLEPLGWDEIREIETAQVYKIYKFPKAV",
"seq1": "SHQIYLRPQGWDEIREVETAKVYNFYKLPKAV",
"seq2": "FRQVYLEPLNWDEIREIQSAKAYNFYKLPKTV",
"seq3": "SRKVYLEPLNFDEIRRLESAKALNFLKLPKTV"
} |
QNNNTHHQEEEEQQQQIIIIFFFFTQQIVVVVIVVVEEEEGGGGLLLLSTTTLLLLEEEEKRRREAAATTTTGEEESNNNLLLLPAAAATTTDDDDDDDDQMMMQQQQIVVAVLVVMMMMTAAAMLMLRKKKKKKKQQQQYLLLKRKKAAAA--S---D---L---W---R---V---I---W---F- | {
"seq0": "QTEQIFTVIEGLSLEKETGSLPADDQQIVMTMRKQYKA",
"seq1": "NHEQIFQVVEGLTLERATENLATDDMQVLMALKKQLRA",
"seq2": "NHEQIFQVVEGLTLERATENLATDDMQVVMAMKKQLKASDLWRVIWF",
"seq3": "NQEQIFIVVEGLTLERATENLATDDMQAVMALKKQLKA"
} |
LLKIFFFFQQQQLLLLKKKKFLYYAAAALLLLATTTLLLLEEEEQLMPQQQQVIITEEEEIII-RRRQDDDDVVAADDDETATTCCCATAAAFFFFTTTTYYRYVLLLVVVVQQRRNPPPAVSAFFLY | {
"seq0": "LFQLKFALALEQQVEIRDVDTCTFTYVVQNAF",
"seq1": "LFQLKLALTLELQIEIRDVDACAFTYLVQPVF",
"seq2": "KFQLKYALTLEMQIEIRDADTCAFTRLVRPSL",
"seq3": "IFQLKYALTLEPQTEQDAETAAFTYLVRPAY"
} |
TVVVYFFYNNNNTDDDAAAAEEEEMSTTKKKKGGGGPPPPRRRRRRRRKKKKFFFFFFFFSTTTYYYYLFFFGGGGGGGGEEEESSSSAAAATTTAYYYHSKRPPPPPPSSGEEEERNNNKKKKALAT | {
"seq0": "TYNTAEMKGPRRKFFSYLGGESATYSPPERKA",
"seq1": "VFNDAESKGPRRKFFTYFGGESATYKPSENKL",
"seq2": "VFNDAETKGPRRKFFTYFGGESATYRPSENKA",
"seq3": "VYNDAETKGPRRKFFTYFGGESAAHPPGENKT"
} |
RRRREEEELLILVVIVYYYYAAPAIVVIGGGGSTVTLLFLVVVIHHQRFFMFAASSH---AAKAPPPPMMQMDDDDGGAGQQSQLLLLNNNNKRRRYYYYLLLLDDEDEEEESSSSTTTTMMMMRRKRGGGAILLLTTTTNNNNMMTKPPPPDDDEDDDCQQQQVVAVAACC | {
"seq0": "RELVYAIGSLVHFAHAPMDGQLNKYLDESTMRGITNMPDDQVA",
"seq1": "RELVYAVGTLVHFAAPMDGQLNRYLDESTMRGLTNMPDDQVA",
"seq2": "REIIYPVGVFVQMSKPQDASLNRYLEESTMKGLTNTPDDQAC",
"seq3": "RELVYAIGTLIRFSAPMDGQLNRYLDESTMRALTNKPECQVC"
} |
NNNNDDDDKKKKNNNVVVVVYYYYRHRRVAAASAASAAAAQKKQTTTTLLLLVTTVGGGGEEEESSSSDDDDLLLLAAARPPPPAAAAKQQKPPP-TMM-SSS-EEE-IIM-RRR-EEE-HSS-KKH- | {
"seq0": "NDKNVYRVSAQTLVGESDLAPAKPTSEIREHK",
"seq1": "NDKNVYHAAAKTLTGESDLAPAQPMSEIRESK",
"seq2": "NDKNVYRAAAKTLTGESDLAPAQPMSEMRESH",
"seq3": "NDKVVYRASAQTLVGESDLRPAK"
} |
MSSAAAASLVVIPPPPAAAHVVVLMNNMIVVIRRTQEKNEAVVAKRRPGGGGQ--QP--PT--SE--QG--AE--AT--TE--ER--KL--LY--YT--PV--VE--KG--GV--MI--II--ID--DM--IV--VC--CI--IG--GR--RP--PQ--QR--RL--LF--LI--VY--YE--EK--KL--LF--FLLLLSSSSKKKKRRRRYNNG-VV--II--MM--GG-HHQHFLLYYYYYYYYYQTNQFFFFEEEEAAAAKKEKKKKKPPPPNNNNGEEG-VV--LI--EE--KK--LI--RR--EE--FF--LL-ALLADAADTTNT | {
"seq0": "MALPAVMIREAKGQPTEGETERLYTVEGVIIDMVCIGRPQRLFIYEKLFLSKRYHFYYQFEAKKPNGADT",
"seq1": "SAVPAVNVRKVRGLSKRNVIMGHLYYTFEAKKPNEVLEKLREFLLAT",
"seq2": "SAVPAVNVTNVRGLSKRNVIMGQLYYNFEAEKPNEVIEKIREFLLAN",
"seq3": "ASIPHLMIQEAPGQPSQAATEKLYPVKGMIIDIVCIGRPQRLLVYEKLFLSKRGHYYYQFEAKKPNGADT"
} |
AAAAYYYYTEEELLLLKKQKRRRRIRIREEPEILILVVVVMMMMEEEEPPPPLLILGYGGEEQETTGTIIIIWFPWFFFFRKRVKKNKRRKR---V---I---I---A---N---H---Q---G---LLLLLYYFYYYYYEEEEYYFYVLIIQQVQHHHHGGRGLMLLVV-VDD-DEE-EST-KLLLL | {
"seq0": "AYTLKRIEIVMEPLGETIWFRKRLYYEYVQHGLVDESL",
"seq1": "AYELKRRELVMEPLYETIFFKKRLYYEYLQHGMVDETL",
"seq2": "AYELQRIPIVMEPIGQGIPFRNKLFYEFIVHRLL",
"seq3": "AYELKRRELVMEPLGETIWFVKRVIIANHQGLLYYEYIQHGLVDEKL"
} |
EEEEFFFFVVAVMLLMNNNKDDDDAAQMFFFFEEDETTSTIIIIYYYYFFFFACCAYFYYSEENSSSSKKKKGTTTTSTTSSNSLLLLQLLQIIIILLLLNSRSVVAVMMMVGGGGTMMMVLLVIIVIKKRKEKEESAASGGGGEDEETPPTIIIILLLLVVVV | {
"seq0": "EFVMNDAFETIYFAYSSKGTSLQILNVMGTVIKESGETILV",
"seq1": "EFVLNDAFETIYFCFESKTSSLLILSVMGMLIKKAGDPILV",
"seq2": "EFALNDQFDSIYFCYESKTTNLLILRAMGMLVREAGEPILV",
"seq3": "EFVMKDMFETIYFAYNSKTTSLQILSVVGMVIKESGETILV"
} |
DNDDFFFFLLLLVGVVFFFFVVVVPYYYDDEDNQQQRRRRYYYYCACCIIIIEDDDNSGY-L---A---S---A---P---A---G---C---S---L---L---K---Q---P---M---L---L---R---E---L---F---S---C---K---V---T---T---V---S---W---S---Q---F---A---G---P---H---S---D---E---L---L--S-SAE-EESEACRRHRIIIIVLLLGGGTTTTAVSAAYFFFEEEEAAAATSTTLRLLIIIIKKKKEEEAQNNNIIIILVLLRKKKTEASFFFFKRRRNSNNDVSS | {
"seq0": "DFLVFVPDNRYCIENSESRIVGTVYEATLIKEQILRTFKND",
"seq1": "NFLGFVYDQRYAIDSLASAPAGCSLLKQPMLLRELFSCKVTTVSWSQFAGPHSDELLERILGTSFEASRIKENIVKEFRSV",
"seq2": "DFLVFVYEQRYCIDGSEAHILGTAFEATLIKENILKAFRNS",
"seq3": "DFLVFVYDQRYCIDYAECRILTAAFEATLIKANILKSFRNS"
} |
SGSGCIIIDDDDPSPPLVLIVVVVKKKKGGGGCLCLLFLYVVVLDEDDKKKKQLLLGAAAMMLLGGGGGGGGEEEESSSSEEEEHEHHSSSAPPPPFPSADDDDVVVVWYYYSAAASSSSYFYYEDDDTTTTNSQNQNQQLLLL | {
"seq0": "SCDPLVKGCLVDKQGMGGESEHSPFDVWSSYETNQL",
"seq1": "GIDSVVKGLFVEKLAMGGESEESPPDVYASFDTSNL",
"seq2": "SIDPLVKGCLVDKLALGGESEHSPSDVYASYDTQQL",
"seq3": "GIDPIVKGLYLDKLALGGESEHAPADVYASYDTNQL"
} |
RRRRKKKKEEEESTSSKDDDPPPPSSSSEEEELLLLLLLLPPPPGGGGTTTTVVVVEEEEAAAAEEEDHHHHSGSSEQDEKKRKSASSTSTTNNKNYHYYTATAMLLLTTTTEDEDTTTTPPPPVVVVLLLLLLLL | {
"seq0": "RKESKPSELLPGTVEAEHSEKSTNYTMTETPVLL",
"seq1": "RKETDPSELLPGTVEAEHGQKASNHALTDTPVLL",
"seq2": "RKESDPSELLPGTVEAEHSDRSTKYTLTETPVLL",
"seq3": "RKESDPSELLPGTVEADHSEKSTNYALTDTPVLL"
} |
TCTCRRRRASASTTTTDDDDLLLLPPPPPPYPPEPEIIVVAAAAGGDGRRRRVFVFGGGGTPSPGGGGVAVANDNDVLLLEDEDYHYHVVIVILLLEKKRLLLLTTATPPPPCICIGAGGSDDDKKKKMALAVAVVKKKKDEDEHNNNKRKRFFFFDGDGKKKK | {
"seq0": "TRATDLPPPIAGRVGTGVNVEYVIELTPCGSKMVKDHKFDK",
"seq1": "CRSTDLPPEIAGRFGPGADLDHVLKLTPIADKAAKENRFGK",
"seq2": "TRATDLPYPVADRVGSGVNLEYILKLAPCGDKLVKDNKFDK",
"seq3": "CRSTDLPPEVAGRFGPGADLDHVLRLTPIGDKAVKENRFGK"
} |
PPPPAAAKAAAAGHGGSSSSLLLLKSRKSSSPSSSSCLCCWWWWGAGTKKKKNNVNLLLLLLVLAVAAGGGGYFYYQWQQQ--AM--MM--MP--PFEFFVVVV---L---I---V---G---V---L---G---Y---R---A---E---I---V---L---F---Y---S---G---Q---C---P---V---I---E---N---P---T---K---F---R---T---P---G---D---E---K---D---R---R---P---A---Y---L---V---MGAGGESEEGGGGAKKAATAAKKKKRRRRSSSSTTTTPPPPPPPPLLLL | {
"seq0": "PAAGSLKSSCWGKNLLAGYQQMMPFVGEGAAKRSTPPL",
"seq1": "PAAHSLSSSLWAKNLLVGFWEVASGKTKRSTPPL",
"seq2": "PAAGSLRSSCWGKVLVAGYQFVGEGKAKRSTPPL",
"seq3": "PKAGSLKPSCWTKNLLAGYQAMMPFVLIVGVLGYRAEIVLFYSGQCPVIENPTKFRTPGDEKDRRPAYLVMGEGAAKRSTPPL"
} |
AAAASSFFFLFFMASSNNNNDDDDASAAIILLEEEELLLIDDDDELVVSSSSLLLLKRKRVVIVGGGGEEEEQQQQDDDDNNNNLLQLKSDDENKKHQEH--I---R---D---D---K---A---L---Q---G---M---I-IVIIAAAAAAAAFCCCQRQQEEDDTGTEPPPPEESSVVAAKKKSKKKKDDDDDDGGKKKKSASS | {
"seq0": "ASFMNDAIELDESLKVGEQDNLKEHIAAFQETPEVKKDDKS",
"seq1": "ASLANDSIELDLSLRVGEQDNLSNQVAACREGPEVKKDDKA",
"seq2": "AFFSNDALELDVSLKIGEQDNQDKEIRDDKALQGMIIAACQDTPSAKKDGKS",
"seq3": "AFFSNDALEIDVSLRVGEQDNLDKHIAACQDEPSASKDGKS"
} |
QKKKKKKKLLLLTN--MM--VI--PP--LL--LL--KH--LL--FL--TT--LY--VV--TS--IV--EE--VV--QQ--DA--IL--LY--NT--WW--GG--GG--DD--KK--PP--EE--EE--KE--VV--FF--TP-- | {
"seq0": "QKLTMVPLLKLFTLVTIEVQDILNWGGDKPEEKVFT",
"seq1": "KKLNMIPLLHLLTYVSVEVQALYTWGGDKPEEEVFP",
"seq2": "KKL",
"seq3": "KKL"
} |
VIVVLLLLGGGGLLLLGGGGVVVIEEEEQEQKFFFFWWWWDQDDQQQNLLLLEDEESSSSPPPPFFFFVVIVGGGGGGGGIVVVYYYYIIILIIIVVGGGDTDDRRRKPRPPDDDTGSGGMQMMYYYYENKKLILL | {
"seq0": "VLGLGVEQFWDQLESPFVGGIYIIVDRPDGMYEL",
"seq1": "ILGLGVEEFWQQLDSPFVGGVYIIGTRRDSQYNI",
"seq2": "VLGLGVEQFWDQLESPFIGGVYIIGDRPDGMYKL",
"seq3": "VLGLGIEKFWDNLESPFVGGVYLVGDKPTGMYKL"
} |
DEEECCCCLAALVATLILLIKKKKGGGGSSTSLLLLPPPPNNNNTTTTHHHHDEDDPPPPVFMMLLLLRRRRAAAATTSTVVVVYFFYEEEEVVVVKKKKDDLDVVVVVLVVRRRREDEEFFFFEEEDTAASKEEE | {
"seq0": "DCLVIKGSLPNTHDPVLRATVYEVKDVVREFETK",
"seq1": "ECAALKGSLPNTHEPFLRATVFEVKDVLRDFEAE",
"seq2": "ECATLKGTLPNTHDPMLRASVFEVKLVVREFEAE",
"seq3": "ECLLIKGSLPNTHDPMLRATVYEVKDVVREFDSE"
} |
FFFFEAET-SST-KTT-VVI-PSS-EGD-HHH-SSS-VVV-FFF-TTV-HCI-III-LLL-SSS-EHK-DDD-LYL-PPP-ASS-KKK-ATT-PPP-KKK-AAG-NDN-AAQ-LLL-AAA-IIIGNANFFFF | {
"seq0": "FEGF",
"seq1": "FASKVPEHSVFTHILSEDLPAKAPKANALAINF",
"seq2": "FESTVSGHSVFTCILSHDYPSKTPKADALAIAF",
"seq3": "FTTTISDHSVFVIILSKDLPSKTPKGNQLAINF"
} |
EDEEAAAATTTTLLLLAAAALLLFPPPPQQQQIVVVPPSSEEEAVTVV--P-VVIIKKKKVVVVNNFNTTTAGQTQKKKKEEEETSTTYYGGMMMMEEEEAPPPDDDD--YFRRRRLLLLEEEEKKGGAAAAVVKK | {
"seq0": "EATLALPQIPEVVKVNTGKETYMEADRLEKAV",
"seq1": "DATLALPQVPETVKVNTQKESYMEPDRLEKAV",
"seq2": "EATLALPQVSEVPIKVFTTKETGMEPDYRLEGAK",
"seq3": "EATLAFPQVSAVIKVNAQKETGMEPDFRLEGAK"
} |
LLLLPPRPRRERVLVLGGGGEDEDAVVVAAAAVLVVAAAAVIVITAAAAAPSVVVV-MVMAAAAEVPVLLLHRKRKGDGDNNNRDDDDMLMLVIIIAAAAIVLVYLILIIIILLLLEKEKNNCNTTTTLL-L | {
"seq0": "LPRVGEAAVAVTAVAELRGNDMVAIYILENTL",
"seq1": "LPRLGDVALAIAAVMAVLKDNDLIAVLILKNTL",
"seq2": "LREVGEVAVAVAPVVAPLRGNDMIALIILECT",
"seq3": "LPRLGDVAVAIASVMAVHKDRDLIAVLILKNTL"
} |
--M---I---L---E---K---A-DDDNDDEDGG-GLMMMPPPPGGSGVVVTNNNNGGGGCCC-LLLLPPSRLLLLPPPPVVITTTTQAAAASSSSRRRRQQLMAAAAEEDEKKKKIVILKKKKSTSSHHAQLLLLVVAVKKKKDDNDNSNNSASSTTVTSSSSTQDQVVVVYYTYLLMLGGGGHHSHIIIIVIVVSSSS | {
"seq0": "DDGLPGVNGCLPLPVTASRQAEKIKSHLVKDNSTSTVYLGHIVS",
"seq1": "DDGMPGVNGCLPLPVTASRQAEKVKTHLVKDSATSQVYLGHIIS",
"seq2": "MILEKADEMPSVNGCLSLPITASRLADKIKSALAKNNSVSDVTMGSIVS",
"seq3": "NDGMPGTNGLRLPTQASRMAEKLKSQLVKDNSTSQVYLGHIVS"
} |
AAAAAAAADDDDDDDDPPPPMVMMGAGGVVVVTTTTVILLGGGGSNSSGGGGFFFFYYYYAAAAQTTTKKRRKKKKSSSNTTTTRRRRFFFFGGGGIIIIIIIILLLLIIIILHLLHQHHQQVVSSESLLLLEEAALLLLYYYYTTHKDDEEVVVVFFFVWWWWAAAAVVFFEDEE | {
"seq0": "AADDPMGVTVGSGFYAQKKSTRFGIILILHQSLELYTDVFWAVE",
"seq1": "AADDPVAVTIGNGFYATKKSTRFGIILIHQQSLELYTDVFWAVD",
"seq2": "AADDPMGVTLGSGFYATRKSTRFGIILILHVELALYHEVFWAFE",
"seq3": "AADDPMGVTLGSGFYATRKNTRFGIILILHVSLALYKEVVWAFE"
} |
MMMMPPPPFLLLSSSTEEEENNNNIIIISSSSKSSHTTLTKTTKGAEGIVVILLLLLLLLLFFLTKKKFIIFRSSCYYYYRRRRTEEIAAAADDDDPAAAYYYYWWWWKRRKIIIVKKKKRCCRLRRLKKKK | {
"seq0": "MPFSENISKTKGILLLTFRYRTADPYWKIKRLK",
"seq1": "MPLSENISSTTAVLLFKISYREADAYWRIKCRK",
"seq2": "MPLSENISSLTEVLLFKISYREADAYWRIKCRK",
"seq3": "MPLTENISHTKGILLLKFCYRIADAYWKVKRLK"
} |
LLLLIMVIQQQQQQQQLLLLLLLMSSSSRSSSDDDDAAAADDDDEHHHLLLLMPTTDDDDLLMIGGGGEEEEYYYYGGGGVIIIKPKKTKTTGAGGSSSSLIIIFFFFAAAANNNNQQQQIVKIPPPPEAEE | {
"seq0": "LIQQLLSRDADELMDLGEYGVKTGSLFANQIPE",
"seq1": "LMQQLLSSDADHLPDLGEYGIPKASIFANQVPA",
"seq2": "LVQQLLSSDADHLTDMGEYGIKTGSIFANQKPE",
"seq3": "LIQQLMSSDADHLTDIGEYGIKTGSIFANQIPE"
} |
SASSDDDDGGGGVIVVQQQQQSQQPPPPEEEE-K---Y---S---E---N---C---K---T---T---H---S---E---I---K---V---T---R---V---A---A---V---D---S---K---L-- | {
"seq0": "SDGVQQPE",
"seq1": "ADGIQSPEKYSENCKTTHSEIKVTRVAAVDSKL",
"seq2": "SDGVQQPE",
"seq3": "SDGVQQPE"
} |
FFFFVIII-V--L-GGIIIITIVTDDDDEEEENGKKRRRRLLLLYYYYAASASSSSNNNNDNNDAEAAQQQQNDDDLLLLTRRTTVVVNSSSMMLLSRRSIIIIGGGGVIIVDDDDVIIIKQQKAAAAPPPP | {
"seq0": "FVLITDENRLYASNDAQNLTTNMSIGVDVKAP",
"seq1": "FIVIIDEGRLYASNNEQDLRVSMRIGIDIQAP",
"seq2": "FIGIVDEKRLYSSNNAQDLRVSLRIGIDIQAP",
"seq3": "FIGITDEKRLYASNDAQDLTVSLSIGVDIKAP"
} |
KKKKGGGGVVVVVVVLLLLLCMCCLLLLQQQQLLLLAAALVVVVAAAADDDDRKKKHHHHKKKKLFLFEEEEDDDDPPPPSMQMPPPITTKTESESGGSGMMMTYYYYSSASSASAQDQDDDDDKK-KGGGGWYWWGGGGFMFMRRRRAAAA | {
"seq0": "KGVVLCLQLAVADRHKLEDPSPTEGMYSSQDKGWGFRA",
"seq1": "KGVVLMLQLAVADKHKFEDPMPTSGMYSADDKGYGMRA",
"seq2": "KGVVLCLQLAVADKHKLEDPQPKESMYASQDGWGFRA",
"seq3": "KGVLLCLQLLVADKHKFEDPMITSGTYSADDKGWGMRA"
} |
RRRKPSSPLLLLRRRREESEKKKQIMMILLILVVIIKKKQEEEEVVVVWWWWAAVSAVVVKKKRVVVVDDDDTTTTLLLLHNNNEEEEEEEEQAQQGGGGSSASKKKKVVTVSSSSHHHHRHRRPPPPAESAKKKKPPPPKKKKAAAAKASA | {
"seq0": "RPLREKILVKEVWAAKVDTLHEEQGSKVSHRPAKPKAK",
"seq1": "RSLREKMLVKEVWAVKVDTLNEEAGSKVSHHPEKPKAA",
"seq2": "RSLRSKMIIKEVWVVKVDTLNEEQGAKTSHRPSKPKAS",
"seq3": "KPLREQILIQEVWSVRVDTLNEEQGSKVSHRPAKPKAA"
} |
NKNNSSASWWWWKKKKFFFFTNTTRRRRFFFFGGGGGGGGKKKKIIIIPPPPGGGGAAMSSNNNKDKEFLFFRRRRLLLLMMMMASSSQNQNATVA-G--FFFFKKKKWWWWLLLLYEYYILIIQQQQLLLL | {
"seq0": "NSWKFTRFGGKIPGASKFRLMAQAFKWLYIQL",
"seq1": "KSWKFNRFGGKIPGANDLRLMSNTGFKWLELQL",
"seq2": "NAWKFTRFGGKIPGMNKFRLMSQVFKWLYIQL",
"seq3": "NSWKFTRFGGKIPGSNEFRLMSNAFKWLYIQL"
} |
EQQDRRRRGGGGIIITFFFFAAAARNRNSSNQMMMMGGGGLLLLRRRRTAAASSSSMMMIVVVGNNNNGGGGRRKQAASAPPPPSSSDVVVVHHHHMMMIHHHHTTTSGGGAVVVVHQQQPPPPYYYYLLLSNNNAVVVVIIIIFFFFEEEE | {
"seq0": "ERGIFARSMGLRTSMVNGRAPSVHMHTGVHPYLNVIFE",
"seq1": "QRGIFANSMGLRASMVNGRAPSVHMHTGVQPYLNVIFE",
"seq2": "QRGIFARNMGLRASMVNGKSPSVHMHTGVQPYLNVIFE",
"seq3": "DRGTFANQMGLRASIGNGQAPDVHIHSAVQPYSAVIFE"
} |
WWWWILIIRRRRLLLLILMLHHHHLLLLQQQQSSSGVVFVIIILCLGLDDDDDEEEFFFFEEEEPPPPHHHHAAAAT-TPGGGGPPPPWWWWTTTTKKKKFFFFQHQHVVAVGGGGWWWWPPPPMVMMSSSSVVCCFYFYLLLLCCACDDDK | {
"seq0": "WIRLIHLQSVICDDFEPHATGPWTKFQVGWPMSVFLCD",
"seq1": "WLRLLHLQSVILDEFEPHAGPWTKFHVGWPVSVYLCD",
"seq2": "WIRLMHLQSFIGDEFEPHATGPWTKFQAGWPMSCFLAD",
"seq3": "WIRLLHLQGVLLDEFEPHAPGPWTKFHVGWPMSCYLCK"
} |
LLLLTTTTNNNNIIIIVVLVSSSSEEEQEKQKIILIVVIVEEEEFFFFIVIVFFFFTTETVIVIPPPPKKKKQQYQCCSCMMMMNNNNEEEEVVVMYYHYPPPPYYTYPPPPVSSTGGGGDDDATNNNKRKRLLLLLLLLRRRRAATAFFTL | {
"seq0": "LTNIVSEEIVEFIFTVPKQCMNEVYPYPVGDTKLLRAF",
"seq1": "LTNIVSEKIVEFVFTIPKQCMNEVYPYPSGDNRLLRAF",
"seq2": "LTNILSEQLIEFIFEVPKYSMNEVHPTPSGDNKLLRTT",
"seq3": "LTNIVSQKIVEFVFTIPKQCMNEMYPYPTGANRLLRAL"
} |
QQQQIMIIYYYYRRRRVVVVLLLLQNNNHNNHQLAHGGGGVTTTYYFYTTTTNEEETVVIQEQQVVVVVVVVLVIVKQKKQQQQEEEENNNNFYYFVIIIEGGGNNNNMIMMPPPPGGGGTTTTGGGGAARAGGGGPEPPLLLLLFLLRRRR | {
"seq0": "QIYRVLQHQGVYTNTQVVLKQENFVENMPGTGAGPLLR",
"seq1": "QMYRVLNNLGTYTEVEVVVQQENYIGNIPGTGAGELFR",
"seq2": "QIYRVLNNAGTFTEVQVVIKQENYIGNMPGTGRGPLLR",
"seq3": "QIYRVLNHHGTYTEIQVVVKQENFIGNMPGTGAGPLLR"
} |
AAAAQKKQD-NNKRKKG-GGSNTTDQEDWWWWGRHGEGEEPPPPSSSSTTTTKRRKRRRRHYHHSASSGGDGQQQSNSNN-VI--LI--MH--SS--DD--VV--GE--EE--LL--RC--VT-VVVVSNSS | {
"seq0": "AQDKGSDWGEPSTKRHSGQNVS",
"seq1": "AKRNQWRGPSTRRYAGQSVLMSDVGELRVVN",
"seq2": "AKNKGTEWHEPSTRRHSDQNIIHSDVEELCTVS",
"seq3": "AQNKGTDWGEPSTKRHSGSNVS"
} |
PPPPTSTTRRRRGNGGAAAAPSPSFFFFRNRNAAAAKSKKFFFFIIIIRQRQYYYYVIVVAEPEDDDDVVVVLLLLSAAALLLLPPPQVAAADDDDEKKKAAAAGGGGVLVNYFYFPPPPRQRRAAAA | {
"seq0": "PTRGAPFRAKFIRYVADVLSLPVDEAGVYPRA",
"seq1": "PSRNASFNASFIQYIEDVLALPADKAGLFPQA",
"seq2": "PTRGAPFRAKFIRYVPDVLALPADKAGVYPRA",
"seq3": "PTRGASFNAKFIQYVEDVLALQADKAGNFPRA"
} |
LIIINNSNWWWWENDDGGGGTITTRRRRLLLITMTTDDNDDNDDAAAAHHHHTTTTMVIMSALCAAAAPPPAYCCCYFWYFFFFQQQQHHHHFDNDPPPTVVVVIMMMAAAAQRRERRRRKMMMTVVILVVVQEEERRRRDDDDPPPPRRRR | {
"seq0": "LNWEGTRLTDDAHTMSAPYYFQHFPVIAQRKTLQRDPR",
"seq1": "INWNGIRLMDNAHTVAAPCFFQHDPVMARRMVVERDPR",
"seq2": "ISWDGTRLTNDAHTILAPCWFQHNPVMARRMVVERDPR",
"seq3": "INWDGTRITDDAHTMCAACYFQHDTVMAERMIVERDPR"
} |
QKQQFWWWLLLLNNNNVTTSLLIIIIIIQQQQVVLLTYYYEDKRSDDDLLLLQREEVIIIGGGGTTTTSANKQQQQNNDNPAPPFFFFDDHHLKKKVVVILLLLFFFFWLLLR-RREASSVIV-AAA-EAVVLMRMQRNNAAHAILLLLMMMEKKKAAETSSSC | {
"seq0": "QFLNVLIQVTESLQVGTSQNPFDLVLFWREVAELQAILEAS",
"seq1": "KWLNTLIQVYDDLRIGTAQNAFDKVLFLAIAAMRALMKAS",
"seq2": "QWLNTIIQLYKDLEIGTNQDPFHKVLFLRSVAVRNHLMKES",
"seq3": "QWLNSIIQLYRDLEIGTKQNPFHKILFLRSVMNALMKTC"
} |
LLLLEQDENTTTVVVLQKKKMMMMHHHYYYYFDDDDIV-ARK-KEK-EYY-EGG-GKK-KKK-SII-IED-DLL-LLL-LPP-PFF-IQQQQGGGGGGGGEEEERRRRAAAACVVVDDDATYYYPPPPSSTSLFMVIVIIRRRRE-EED-DDVVVVGGGGFYFF | {
"seq0": "LENVQMHYDIREYGKKIELLPFQGGERACDTPSLIREDVGF",
"seq1": "LQTVKMHYDVKKYGKKIDLLPFQGGERAVDYPSFVRVGY",
"seq2": "LDTVKMHYDQGGERAVDYPTMIREDVGF",
"seq3": "LETLKMYFDAKEEGKSIDLLPIQGGERAVAYPSVIREDVGF"
} |
GGGGAAAAMMLMEQEEGDGD--Y---T---V---R---S---Q-QEEEQQQQGGGARRKRLLLLSCACLLLLGGGGIIIIAKVKSTTTIFIFVVVVSASAFFFFGGGGGSSS--A-KKNRNNNNEKEQIIIILLLLKKKKAAKAEEEEL---E---W---R---A---CSRTWWWWVVVVRRR-PPP-MMM- | {
"seq0": "GAMEGQQGRLSLGIASIVSFGGKNEILKAELEWRACWVRPM",
"seq1": "GAMQDEQGRLCLGIKTFVAFGSKNKILKAESWVRPM",
"seq2": "GALEGYTVRSQEQGKLALGIVTIVSFGSANNEILKKERWVRPM",
"seq3": "GAMEDEQARLCLGIKTFVAFGSRNQILKAETWV"
} |
NNNSEEEEGGGG-III-RRK-AAA-QQQ-LLLMEEQVVVVDDDDSSLSVVVVAAAVKRRKEEEDCCCCTNNNRRRRFFFFVIIVVTTVTTTTFFFFAPPSAAAATTTTIFFVSSSKMMMFDDDDIKKKGGGGALVVSGGSLMML | {
"seq0": "NEGMVDSVAKECTRFVVTFAATISMDIGASL",
"seq1": "NEGIRAQLEVDSVARECNRFITTFPATFSMDKGLGM",
"seq2": "NEGIRAQLEVDLVARECNRFITTFPATFSMDKGVGM",
"seq3": "SEGIKAQLQVDSVVKDCNRFVVTFSATVKFDKGVSL"
} |
IIILVVAADDDDLILLGAGKRSRRSDTTILLLAAAA-N---A---L---L---V---F---A--LLLLMMIMKKRRASAA-N---N--HFYYMLMMAAAASSAARNRRNQNNRKR-SAVAPPPPKRKKLLLLLLRRVIVVYWYYIVIII-IIL-LFK-EER-RRG-GGH-HHT-TTFFFF | {
"seq0": "IVDLGRSIALMKAHMASRNRSPKLLVYIILKRGHTF",
"seq1": "IVDIASDLANALLVFALMKSNNFLASNQKAPRLLIWVF",
"seq2": "IADLGRTLALIRAYMAARNRVPKLRVYIILERGHTF",
"seq3": "LADLKRTLALMRAYMAARNAPKLRVYIIFERGHTF"
} |
ETSTPPPPLVMIGVGGIIIIQQQK-IIL-EEQ-EES-ITTCCCCEEEDIMIVTTTTKKKKDDDDEPEQLLLLGGGGKKKKDEDDS---AVTIFFFFLLLLGGAGAAFESRRRAALPEDEDYYYYDDDDLLLL--I-Q-QQV-VVA-VMLLLV | {
"seq0": "EPLGIQCEITKDELGKDSAFLGASAEYDLQVAL",
"seq1": "TPVVIQIEEICEMTKDPLGKEVFLGARADYDLL",
"seq2": "SPMGIQIEETCEITKDELGKDTFLAFRLEYDLIQVVL",
"seq3": "TPIGIKLQSTCDVTKDQLGKDIFLGERPDYDLQVMV"
} |
NNNGVYVIVIVLEVEATTTNQRHRSSSSEEEE-LLLVVVFKKKKEEEKEEEEDDDDVTV-TSSAVVVVLVLVPGPPKRKLYYYFRRRRMMMMDNDDKKKRLLLLAAANWWWWCAALKKKKTTTTRRRRAKAAKKKKMTMQRRRKYYYEKKKYFFFLLILIMMMFITLFGGGGGGGG | {
"seq0": "NVVETQSEVKEEDVTVLPKYRMDKLAWCKTRAKMRYKFLMIGG",
"seq1": "NYIVTRSELVKEEDTSVVGRYRMNKLAWAKTRKKTRYKFIMTGG",
"seq2": "NVVETHSELVKEEDVSVLPKYRMDKLAWAKTRAKMRYKFLMLGG",
"seq3": "GILANRSELFKKEDAVVPLFRMDRLNWLKTRAKQKEYLIFFGG"
} |
GGGRRRVAPASSSSTTDDNDFFFFGGGGLLLLHNNNRRRLWWWWTTISIIVVPPSKKKKKYYYYGGGGVVVVLPLLGGGGFFFFHHHKLLLLYYYHCCCCGGGNLLLIEEQQQQEENNSNFFFFILLLILIMDDDNRRKKTT-TTTTR | {
"seq0": "GRPSDFGLHRWTIPKYGVLGFHLYCGLEQNFIIDRTT",
"seq1": "GRASDFGLNRWTIPKYGVPGFHLYCGLEQNFLLDRTT",
"seq2": "GVSTNFGLNRWIVSKYGVLGFHLYCGLQESFLIDKT",
"seq3": "RASTDFGLNLWSVKKYGVLGFKLHCNIQENFLMNKTR"
} |
VTTVQQQQSCGCDDDDAASVTDDTVVVLGAAGHHHHGGGRDDDVYYYYQKQQEEEEK-KNVIVKNNNNYYYYQEEEVVVVKKKKGGAGVVLLLLLLKNEYDNNDEEEDAAAAGGGGAAAA-SS-YFLYRRRWCFCCGRRGGGGGKGGLGGGGNNNNFFFLLLLLTTLTPPPSAAAA | {
"seq0": "VQSDATVGHGDYQEKVNYQVKGVLKDEAGAYRCGGKGNFLTPA",
"seq1": "TQCDADVAHGDYKEINYEVKGVLNNEAGASFRFRGGGNFLTPA",
"seq2": "TQGDSDVAHGDYQEKVNYEVKALLENEAGASLRCRGGGNFLLPA",
"seq3": "VQCDVTLGHRVYQENKNYEVKGLLYDDAGAYWCGGLGNLLTSA"
} |
EE-DHH-HYF-F-L-M-L-L-I-I-D-D-L-LVI-ISTSTPPTPEEEERRRRE-E-V-V-N-N-LLLLLLFITTTTTTTTNSNSGGGGAAAAEEEEETETIVIVTTTTLLLLWFWFVVLVAAAAEQEQGGGGEEEEDEDEGAGA | {
"seq0": "EHYVSPEREVNLLTTNGAEEITLWVAEGEDG",
"seq1": "EHFLLIDLITPERLLTTSGAETVTLFVAQGEEA",
"seq2": "STEREVNLFTTNGAEEITLWLAEGEDG",
"seq3": "DHFMLIDLITPERLITTSGAETVTLFVAQGEEA"
} |
LVL-TTTTPPPEMMTATTT-SSENMMLMIRRKQQQQPPSPIIILTTTTIIIIDDDDRRRKYYYYDSNDAESSAAASKKKKTTTESMIMLLAGEEEETTTTNNNNYYYYRSRRHHHHFFFFAAPASSASWWWW | {
"seq0": "LTPMTSMIQPITIDRYDAAKTSLETNYRHFASW",
"seq1": "VTPMTSMRQPITIDRYSEAKTMLETNYSHFASW",
"seq2": "LTPTTELRQSITIDRYNSAKTIAETNYRHFPAW",
"seq3": "TEANMKQPLTIDKYDSSKEMGETNYRHFASW"
} |
IIIVNEEEAAAASSSSFFFFRRRRDDDDGGGPE---SSSSLLLLYLRYITTVAAASFFFYEEEEPPPPGGGGNASNEEEEKKKKIAAVFYYLLILLTSRTSASSEEEETSTTGGEGVVVVVVIVYYYYASSASSSSHQQHRKKKDDGARRRRTVVT | {
"seq0": "INASFRDGESLYIAFEPGNEKIFLTSETGVVYASHRDRT",
"seq1": "IEASFRDGSLLTAFEPGAEKAYISAESGVVYSSQKDRV",
"seq2": "IEASFRDGSLRTAFEPGSEKAYLRSETEVIYSSQKGRV",
"seq3": "VEASFRDPSLYVSYEPGNEKVLLTSETGVVYASHKART"
} |
LLLIVVVLAAAAIAASTTTTRRRRGGGGSASSGGGSERRRFFFFTTMTYYFHGGDGFFFFPPPPAAAAILFILLLLRRRRSSGACCRCTEETKKMKWWWWKGGWQQKQKRRRVVVVASAPSSSSSSVSNAANQQQQLIILYYFYHEEHHHHHRRKRMLLMIIVVEEEE | {
"seq0": "LVAITRGSGEFTYGFPAILRSCTKWKQKVASSNQLYHHRMIE",
"seq1": "LVAATRGAGRFTYGFPALLRSCEKWGQRVSSSAQIYEHRLIE",
"seq2": "LVAATRGSGRFMFDFPAFLRGREMWGKRVASVAQIFEHKLVE",
"seq3": "ILASTRGSSRFTHGFPAILRACTKWWQRVPSSNQLYHHRMVE"
} |
NNNNNNNNSSTSDEEEGGGGYYYYLVLLMMMMLLLLQQQQQQQQEEESEEEENNNRYRYHLFFFKKSKFFFFCTCVHYHNSCCCRVRVHSSSTSTLLLLLLLQLAAAALVLLIIIIYYFYKRKRLRLRFFFFSASSLLSLTVTTVVIIDTTTTTTTPPLPTTTTLLLL | {
"seq0": "NNSDGYLMLQQEENYLKFCHSRHTLLALIYKLFSLTVDTPTL",
"seq1": "NNSEGYVMLQQEENRFKFTYCVSSLLAVIYRRFALVVTTPTL",
"seq2": "NNTEGYLMLQQEENYFSFCHCRSTLQALIFKLFSSTITTLTL",
"seq3": "NNSEGYLMLQQSERHFKFVNCVSLLLALIYRRFSLTITTPTL"
} |
KKKKKKKPSTSSLLLLRRRRAVVVKNNSIMIISAAAMIIVAAA-EEKKSSSSEEEEEVAESPSSDEQEKDKKWWWWEEEEGSGGRRRRDDDEIIIIEEEENNQSQRPPKKKKITTTRRRRLLLLLLLLTTTTPPPPQNQQAVAAFNFFQQQQEQEDRKRRTTTTNTNN | {
"seq0": "KKSLRAKISMAESEESDKWEGRDIENQKIRLLTPQAFQERTN",
"seq1": "KKTLRVNMAIAESEVPEDWESRDIENRKTRLLTPNVNQQKTT",
"seq2": "KKSLRVNIAIAKSEASQKWEGRDIEQPKTRLLTPQAFQERTN",
"seq3": "KPSLRVSIAVKSEESEKWEGREIESPKTRLLTPQAFQDRTN"
} |
GGGGYYYYLLLLSSSSLLLLRRRRYYYYKKKKIIVIKKKPEKKKRKRKVVVVAAAASTTSEPEEIVIVSSSSGEEEAAPAPDEEQQQHAAAPIVVVVVVVAAAAF-FFLLLLKKKKVVVVPQPPPPPI | {
"seq0": "GYLSLRYKIKERVASEISGAPQAIVAFLKVPP",
"seq1": "GYLSLRYKIKKKVATPVSEADQAVVALKVQP",
"seq2": "GYLSLRYKVKKRVATEISEPEQAVVAFLKVPP",
"seq3": "GYLSLRYKIPKKVASEVSEAEHPVVAFLKVPI"
} |
MIIIRRRRIIIIRRRRKKTPGGGDFFIIVVVVLLLVAEEEIITIRRQKAVAAGGSGVVVVGGGGVMLLTTDTYFFFFFFFQQRQSSSSASSSDDDD-PLPCCCCEEGEEEEENNSNRRRRLLLIVVVISSNN | {
"seq0": "MRIRKGFVLAIRAGVGVTYFQSADCEENRLVS",
"seq1": "IRIRKGFVLEIRVGVGMTFFQSSDPCEENRLVS",
"seq2": "IRIRTGIVLETQASVGLDFFRSSDLCGESRLVN",
"seq3": "IRIRPDIVVEIKAGVGLTFFQSSDPCEENRIIN"
} |
DDEDHHHHQQQHIAIAIVVVGGGGFYYYIVIVRRRRLLLLRNRNFFFFLLLLLLLLVIVIRAAADDDDRRRRIVVVETETARAREEEEYLCYVKVSDDDDLLLL-K-KTMMMRNQQKKKEREPEQHQHGGGGTTTTRRRRLLLL | {
"seq0": "DHQIIGFIRLRFLLVRDRIEAEYVDLTRKRQGTRL",
"seq1": "DHQAVGYVRLNFLLIADRVTRELKDLKMNKEHGTRL",
"seq2": "EHQIVGYIRLRFLLVADRVEAECVDLMQKPQGTRL",
"seq3": "DHHAVGYVRLNFLLIADRVTREYSDLKMQEEHGTRL"
} |
VIVVGNGGPPPPEEEQGGGGDDNDLLLLTTKTGSGSAAAATTTALIIL--R---E---L---F---A---R---A---Q---L---A---D---Q---S---S---L---T---V---T---G---G-RR-RGG-GSA-S | {
"seq0": "VGPEGDLTGATLRGS",
"seq1": "INPEGDLTSATIRGA",
"seq2": "VGPEGNLKGATIRELFARAQLADQSSLTVTGG",
"seq3": "VGPQGDLTSAALRGS"
} |
GGAGFF-FQQ-QVV-AYY-YLL-LGG-GAA-ADD-DYS-SIT-TVV-VVV-LII-IQE-ETT-TTT-TKK-KLL-LHH-HLL-LITTTAAAALLLLGGGGDDEEILVVGGGGKKKKYLLIVLLLKKKKDDDDSTSSFFFF | {
"seq0": "GFQVYLGADYIVVIQTTKLHLIALGDIGKYVKDSF",
"seq1": "GFQVYLGADSTVVIETTKLHLTALGDLGKLLKDTF",
"seq2": "ATALGEVGKLLKDSF",
"seq3": "GFQAYLGADSTVLIETTKLHLTALGEVGKILKDSF"
} |
WWWWFFFFVLVVGGGG-T-TDDDDFFFFEEEQILIIRRRRNSNSAAAEGGGGEDEDYYYY-S---L---D---R---A---A---G---T---P---K---L---L---W---Y---D---G---W---Y---T---S---I---E---A---A---S---L---R---K---E---Y---P---E---I---T---K---P--KAKHVVVVDDDDWR-WKKKKENEEIMFMLLILREDEGGAGATAAQQQEPPPPSS-SDE-DKK-KGG-GAS-ADD-YDN-DLL-L | {
"seq0": "WFVGDFEIRNAGEYKVDWKEILRGAQPSDKGADDL",
"seq1": "WFLGTDFELRSAGDYSLDRAAGTPKLLWYDGWYTSIEAASLRKEYPEITKPAVDRKNMLEGTQPSEKGSDNL",
"seq2": "WFVGDFEIRNAGEYKVDKEFIDAAQP",
"seq3": "WFVGTDFQIRSEGDYHVDWKEMLEGAEPSDKGAYDL"
} |
NNNEAAAATTTTMILLRRRRVIIINNNNIIIIIFFFFFFFFNHFSSSSKEKKAVVDYFFYEKKERRRRDDDDRSSRLLLLEKKKRRRR-HH--GG--DD--ND--MY--VV--TT--LL--NN--TT--AA--GG--EE- | {
"seq0": "NATMRVNIIFFSKAYERDRLER",
"seq1": "NATIRINIFFNSEVFKRDSLKRHGDNMVTLNTAGE",
"seq2": "NATLRINIFFHSKVFKRDSLKRHGDDYVTLNTAGE",
"seq3": "EATLRINIFFFSKDYERDRLKR"
} |
GGGGSASSAAAMNNDNEDEREQQEAAAAAAAAAAAAFYFFDDDDKKKKSRRRQQQQGGGGEEEEIIMISSSKQQKQTTTTTTTTLLFLGGGKTTTTFFFFPPPPAAAAKKKKYYYYPPPPPPPPFFFFTTTSGGGGVVVVDDDDGGAGYYYYYFYYNNNNRKRKNGNN | {
"seq0": "GSANEEAAAFDKSQGEISQTTLGTFPAKYPPFTGVDGYYNRN",
"seq1": "GAANDQAAAYDKRQGEISQTTLGTFPAKYPPFTGVDGYFNKG",
"seq2": "GSADEQAAAFDKRQGEMSKTTFGTFPAKYPPFTGVDAYYNRN",
"seq3": "GSMNREAAAFDKRQGEIKQTTLKTFPAKYPPFSGVDGYYNKN"
} |
VVVVILIIEEEEDNNNLVVVKKKKYHYHLLLLTTTVIMMLLLLFR-KRS-VTN-NGL-LLG-GGL-LIA-ASN-NNEEED-L---S--AAAAWWWWAASAGGGGLLLLIVIAQQEQIITIKSKKNNNNLLLLNNNK-Y---L---P---C---G--IIVILLLLTKKQSSSSSGGGPPPPLLLLKEEESSSSLLLL | {
"seq0": "VIEDLKYLTILRSNLGLANEAWAGLIQIKNLNILTSSPLKSL",
"seq1": "VLENVKHLTMLELSAWAGLVQISNLNYLPCGILKSGPLESL",
"seq2": "VIENVKYLTMLKVNLGLANEAWSGLIETKNLNVLKSGPLESL",
"seq3": "VIENVKHLVLFRTGLGISNDAWAGLAQIKNLKILQSGPLESL"
} |
QRHQEEQEMMMMPPPPIIIITFFYAAAAVVVVPPPPEKEEAAAAFIFFQQQQIIIIAAAAESSEDDDDGGSGPPPPAAAASSSSHHHHAHRAVVIVVVVVEEEELLLLVVMVHHQHPPPPAAAATTTTHHHHDDDDTTPTPPPPIIIIYMKYNSASTTFT | {
"seq0": "QEMPITAVPEAFQIAEDGPASHAVVELVHPATHDTPIYNT",
"seq1": "REMPIFAVPKAIQIASDGPASHHVVELVHPATHDTPIMST",
"seq2": "HQMPIFAVPEAFQIASDSPASHRIVELMQPATHDPPIKAF",
"seq3": "QEMPIYAVPEAFQIAEDGPASHAVVELVHPATHDTPIYST"
} |
PPPPSSSSQNQNKKKK-V-TVVVVDNDNEEEESSSSITITGGGGIIIIFFFFGGGRGNNNLLLLLLMHMLLLAAMATKTTDEDERKRK--S---L---D---K---I---I---V---E---Y---K---Y---R---E---A---T-DDDDPPPPLLILVACAWWWWEENEEEEELLLLTTTTDDDDVVVVDEEELLLLEN-ERR-RRRRREEEDQQQQGGGG-R--HHHH | {
"seq0": "PSQKVDESIGIFGGLLMATDRDPLVWEELTDVDLERREQGH",
"seq1": "PSNKVVNESTGIFGNLLLAKEKDPLAWEELTDVELNRREQGRH",
"seq2": "PSQKVDESIGIFGNLMLMTDRSLDKIIVEYKYREATDPICWNELTDVELREQGH",
"seq3": "PSNKTVNESTGIFRNLHLATEKDPLAWEELTDVELERRDQGH"
} |
LLLLYYYYVVVVAAEAGGGGNNNNLLLLENNNLLLLRRRRQDDTGNNNPPPPQKQQAGGAMMMMDHHHASTTEKEETTTTEEEEHSSSLVILRRRRDDDDVIVVGGGGVLVVKRRKENHEWWWWIIIINTNESSSS | {
"seq0": "LYVAGNLELRQGPQAMDAETEHLRDVGVKEWINS",
"seq1": "LYVAGNLNLRDNPKGMHSKTESVRDIGLRNWITS",
"seq2": "LYVEGNLNLRDNPQGMHTETESIRDVGVRHWINS",
"seq3": "LYVAGNLNLRTNPQAMHTETESLRDVGVKEWIES"
} |
ILILFFFFKKKK-LLL-IIILLLLQSQQFYFYVLVLKKKKKNNNQQQQQEQQGGGGMQQQQEEEPPPPNDNHRRRRIIIIYYYYEEEEKNKNRKRRGGGGAATALLLLKRRRRRRRDNNNGGGGKEEESGSGTTTTKKKKLLLLQQQQGLGGSVAAILIVEEEEAPSP | {
"seq0": "IFKLQFVKKQQGMQPNRIYEKRGALKRDGKSTKLQGSIEA",
"seq1": "LFKLILSYLKNQEGQEPDRIYENKGALRRNGEGTKLQLVLEP",
"seq2": "IFKLILQFVKNQQGQEPNRIYEKRGTLRRNGESTKLQGAIES",
"seq3": "LFKLILQYLKNQQGQEPHRIYENRGALRRNGEGTKLQGAVEP"
} |
NHHHAAAAQKKKNNNNRVVVEEEEPPPPSWWWQQQQNNKNIIIINSSSTTTTVVHVTTTTEEEEEQQQEEEESSTGGGGGK-D-EEEEAAVAEEEQMIIIV---A---V---L---L---L---F---R---TTST--V---A-QQQKIIIIPAPAGGGG--I-RRRRHHHHEEEEGGGGEEEEFFLFTTTT | {
"seq0": "NAQNREPSQNINTVTEEESGKEAEMVAVLLLFRTQIPGRHEGEFT",
"seq1": "HAKNVEPWQNISTVTEQESGEAEITQIAGRHEGEFT",
"seq2": "HAKNVEPWQKISTHTEQETGDEVEISVAQIPGIRHEGELT",
"seq3": "HAKNVEPWQNISTVTEQEGGEAQITKIAGRHEGEFT"
} |
KKKKTTTTVVVVGRAATTTTTKTTILLLLLLLHHWW-SNSTNKTRTRRGGGGDEDDYRFFLLLLILLLFFLLWWWWMLMMSS--WW--II--PP--TN--GG--SK--VL--RKRRTAAAPPPPKKKKLVVVLLLL--L-VVVVEPEEKQ--WW--CCAAKKKKLLVVAAAAEEEEREEEILLL | {
"seq0": "KTVGTTILHTRGDYLIFWMSWIPTGSVRTPKLLVEKWCKLAERI",
"seq1": "KTVRTKLLHSNTGERLLFWLSWIPNGKLKAPKVLVPQWCKLAEEL",
"seq2": "KTVATTLLWNKRGDFLLLWMRAPKVLLVEAKVAEEL",
"seq3": "KTVATTLLWSTRGDFLLLWMRAPKVLVEAKVAEEL"
} |
VVVAEEQEEEDEMLLMSSSLYYYYLFVLLISLKMMKAAVANQENDHNDAAYAQNSKIVVVHQLGEEEQLLLLTMMTNK-NYF-YRR-RII-ILL-LYY-YRRRRRRRRNNNNDDDD--N-RRRRMLLLSTTVEEEEIIVV | {
"seq0": "VEEMSYLLKANDAQIHELTNYRILYRRNDRMSEI",
"seq1": "VEELSYFIMAQHANVQELMKFRILYRRNDRLTEI",
"seq2": "VQDLSYVSMVENYSVLELMRRNDNRLTEV",
"seq3": "AEEMLYLLKANDAKVGQLTNYRILYRRNDRLVEV"
} |
SKSQIIVIKPKPVVVVAAAAEKEKEEEE-A---P---K---E---S---G--FFFFDGDGKRKKIIIIFFFFSS-SVM--A--AS--NDE-ESG-GQS-QIL-IQQ-QDE-DGG-GTT-TQE-EEE-EAF-AFVFFVAVVEQEEHHHHIIIITTTTNNDNGGGGEETEAVVVSTASDDDDIVIVAAAAGGDGRRRRIVVV | {
"seq0": "SIKVAEEFDKIFSVASDSQIQDGTQEAFVEHITNGEASDIAGRI",
"seq1": "KIPVAKEAPKESGFGRIFSMEGSLQEGTEEFVAQHITNGEVTDVAGRV",
"seq2": "SVKVAEEFDKIFFVEHITDGTVADIADRV",
"seq3": "QIPVAKEFGKIFSANEGQIQDGTEEAFVEHITNGEVSDVAGRV"
} |
QQQQVVVVPPPPTTTTKKKKAAAANNHNLQGGTTTTNASSAAAALLLLMVVVAAAAYYYFQQQQRRKKAAAAPPPPIVPLATDDWWWWKKKKFFFLK---I---D---T---S---F---E---K---NNNNQQQQYWWWNSASKQRQSRNNQEEEIILLPPPPFYYYPPPPYYYYAGAG | {
"seq0": "QVPTKANLTNALMAYQRAPIAWKFKIDTSFEKNQYNKSQIPFPYA",
"seq1": "QVPTKANQTAALVAYQRAPVTWKFNQWSQREIPYPYG",
"seq2": "QVPTKAHGTSALVAYQKAPPDWKFNQWARNELPYPYA",
"seq3": "QVPTKANGTSALVAFQKAPLDWKLNQWSQNELPYPYG"
} |
TTTTVIIVYVVYLLLLPPPPLLLLTAATVVVVLLLLANNAQRRNGGGGAPPGSGGSEEEESAASLIILFFFFAAAASPGAEEEERRRRPPPPIVVFNYYHMFFKDDDDQQRQYWWWYYYYLLLMEEEESSSSAGGGKKKKFIIIAEEQTSST | {
"seq0": "TVYLPLTVLAQGASESLFASERPINMDQYYLESAKFAT",
"seq1": "TIVLPLAVLNRGPGEAIFAPERPVYFDQWYLESGKIES",
"seq2": "TIVLPLAVLNRGPGEAIFAGERPVYFDRWYLESGKIES",
"seq3": "TVYLPLTVLANGGSESLFAAERPFHKDQWYMESGKIQT"
} |
LLLLSSSTSAAADDDDFYFFGITGHDHHTTTTCFFCVMFV-I---H---A---P---F---K---H---S---N---A---L---H---K---R---T---D---R---I---E---L---L---T---A---E---D---L---V---N---L---I---T---A---G---L---D---G--YYYYLLLLQQQQTVVTA-LII-IID-NDLLLL--Q---I---E---M---F---T---K---K---R---Y---A---L-VVVVRRRRQRRQEESEPPPPVVIARRRRYAYYSSSS--R---K---K---Q---Y---Y---P---M---A-SGGKQQMQRRRRLLLLKSDK-GGGGGGD | {
"seq0": "LSSDFGHTCVYLQTAIDLVRQEPVRYSSQRLKG",
"seq1": "LSADYIDTFMIHAPFKHSNALHKRTDRIELLTAEDLVNLITAGLDGYLQVLVRREPVRASGQRLSGG",
"seq2": "LSADFTHTFFYLQVLINLQIEMFTKKRYALVRRSPIRYSRKKQYYPMAGMRLDGG",
"seq3": "LTADFGHTCVYLQTIIDLVRQEPARYSKQRLKGD"
} |
ATTTSSTSGGGGPPPPGKKKVVVVVVVVIMMLIVVVLSMMVVVVRRRREEAEEEDEPPPPEEEEKKTKFFFFHHHQPPPPGGGGATTTYYFYKKKDLAALWWWWDDDDKKKKLLLIFFFFSDSSEEEELLLLQQQQ | {
"seq0": "ASGPGVVIILVREEPEKFHPGAYKLWDKLFSELQ",
"seq1": "TSGPKVVMVSVREEPEKFHPGTYKAWDKLFDELQ",
"seq2": "TTGPKVVMVMVRADPETFHPGTFKAWDKLFSELQ",
"seq3": "TSGPKVVLVMVREEPEKFQPGTYDLWDKIFSELQ"
} |
DDDDTSSTRRRKREESYYFYKEEKDEEDEEEERKKRVVVVAKKADDDDSSSSLILLTTTTIIIIDDDESDSSEVVERRRREEEERRKRLFFLAHHPPPPPSTSSPPPPHHHHGGGGMNNNIVVIVVVVASSSMLMM | {
"seq0": "DTRRYKDERVADSLTIDSERERLAPSPHGMIVAM",
"seq1": "DSREYEEEKVKDSITIDDVRERFHPTPHGNVVSL",
"seq2": "DSREFEEEKVKDSLTIDSVREKFHPSPHGNVVSM",
"seq3": "DTKSYKDERVADSLTIESERERLPPSPHGNIVSM"
} |
HYYYFFFFSPSPQQQQMMRMLLYLRRYRKKKKGGGGKKKKPPPPRRRKNNINIIIIASSSYYYYQQQQEEDERRRRDDDDVVAIDDDGTTTTLMLMILLILLMLNNYNMQMQMMMMLLLIKKKKGGG-DDD-EEE-ETE- | {
"seq0": "HFSQMLRKGKPRNIAYQERDVDTLILNMMLKGDEE",
"seq1": "YFPQMLRKGKPRNISYQERDVDTMLLNQMLKGDET",
"seq2": "YFSQRYYKGKPRIISYQDRDADTLLMYMMLKGDEE",
"seq3": "YFPQMLRKGKPKNISYQERDIGTMILNQMIK"
} |
KNNNAASCEKEDSQSSFFFFSNSQVIVVDDDDQQQQEEEAPPPPVVAVHRHHIIILLLLARRRRQQQQGAGGIIIVMMMMWWWWEDEELILLYFYYNRRRLFLLEEESEEEENNNNATTKAAAANNQNLLLLGGGGFYFFAAAAQQQK | {
"seq0": "KAESFSVDQEPVHILRQGIMWELYNLEENAANLGFAQ",
"seq1": "NAKQFNIDQEPVRILRQAIMWDIFRFEENTANLGYAQ",
"seq2": "NSESFSVDQEPAHILRQGIMWELYRLEENTAQLGFAQ",
"seq3": "NCDSFQVDQAPVHLARQGVMWELYRLSENKANLGFAK"
} |
KKKKFLLLEPEEDDDDRRRREEEEAMMMRRRQDAEAAAAAVAAARRRRHYYYNKNSLLLLCCCCLWWWFFFFYFYYA-A-D-D---R---K---R-L-L-V-V-V-V-A-S-L-I-K-K-E-E-KTTTWWFWGSSSTSTSQIKIAVIVKGGGDEDETTTTIMIVAAAAEEEENNDNLLLLQEEE | {
"seq0": "KFEDREARDAVRHNLCLFYADLVVALKEKWGTQAKDTIAENLQ",
"seq1": "KLPDREMRAAARYKLCWFFTWSSIVGETMAENLE",
"seq2": "KLEDREMREAARYNLCWFYADRKRLVVSIKETFSTKIGDTIAEDLE",
"seq3": "KLEDREMQAAARYSLCWFYTWSSIVGETVAENLE"
} |
YYYYIIIILLLLLGLAPPPPKKKKYYYYNNNNWWWWKKKKLLLLKNKNDEDEQQQQLLLLLLLLD---L---L---TPTSAAAAEEEEQQQKKKKRGGGGYYYYETDSPPPPQQQQEEEEHHHHDDDDLLLIYYYYHHYR--R---F-KKKKKTTTLVLVEEAQPPPPCTCT | {
"seq0": "YILLPKYNWKLKDQLLDLLTAEQKGYEPQEHDLYHKKLEPC",
"seq1": "YILGPKYNWKLNEQLLPAEQKGYTPQEHDLYHKTVEPT",
"seq2": "YILLPKYNWKLKDQLLTAEQKGYDPQEHDLYYRFKTLAPC",
"seq3": "YILAPKYNWKLNEQLLSAEKRGYSPQEHDIYRKTVQPT"
} |
Multiple Sequence Alignment as a Sequence-to-Sequence Learning Problem
Abstract:
The sequence alignment problem is one of the most fundamental problems in bioinformatics and a plethora of methods were devised to tackle it. Here we introduce BetaAlign, a methodology for aligning sequences using an NLP approach. BetaAlign accounts for the possible variability of the evolutionary process among different datasets by using an ensemble of transformers, each trained on millions of samples generated from a different evolutionary model. Our approach leads to alignment accuracy that is similar and often better than commonly used methods, such as MAFFT, DIALIGN, ClustalW, T-Coffee, PRANK, and MUSCLE.
An illustration of aligning sequences with sequence-to-sequence learning. (a) Consider two input sequences "AAG" and "ACGG". (b) The result of encoding the unaligned sequences into the source language (Concat representation). (c) The sentence from the source language is translated to the target language via a transformer model. (d) The translated sentence in the target language (Spaces representation). (e) The resulting alignment, decoded from the translated sentence, in which "AA-G" is aligned to "ACGG". The transformer architecture illustration is adapted from (Vaswani et al., 2017).
Data:
We used SpartaABC (Loewenthal et al., 2021) to generate millions of true alignments. SpartaABC requires the following input: (1) a rooted phylogenetic tree, which includes a topology and branch lengths; (2) a substitution model (amino acids or nucleotides); (3) root sequence length; (4) the indel model parameters, which include: insertion rate (R_I), deletion rate (R_D), a parameter for the insertion Zipfian distribution (A_I), and a parameter for the deletion Zipfian distribution (A_D). MSAs were simulated along random phylogenetic tree topologies generated using the program ETE version 3.0 (Huerta-Cepas et al., 2016) with default parameters.
We generated 1,495,000, 2,000 and 3,000, protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range (0.5,1.0). Next, the sequences were generated using SpartaABC with the following parameters: R_I,R_D \in (0.0,0.05), A_I, A_D \in (1.01,2.0). The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range [32,44]. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides (0.37, 0.166, 0.307, 0.158), in the order "T", "C", "A" and "G"; (2) with the substitutions rate (0.444, 0.0843, 0.116, 0.107, 0.00027), in the order "a", "b", "c", "d", and "e" for the substitution matrix.
Example:
The following example correspond for the illustrated MSA in the figure above:
{"MSA": "AAAC-GGG", "unaligned_seqs": {"seq0": "AAG", "seq1": "ACGG"}}
APA
Dotan, E., Belinkov, Y., Avram, O., Wygoda, E., Ecker, N., Alburquerque, M., Keren, O., Loewenthal, G., & Pupko T. (2023). Multiple sequence alignment as a sequence-to-sequence learning problem. The Eleventh International Conference on Learning Representations (ICLR 2023).
BibTeX
@article{Dotan_multiple_2023,
author = {Dotan, Edo and Belinkov, Yonatan and Avram, Oren and Wygoda, Elya and Ecker, Noa and Alburquerque, Michael and Keren, Omri and Loewenthal, Gil and Pupko, Tal},
month = aug,
title = {{Multiple sequence alignment as a sequence-to-sequence learning problem}},
year = {2023}
}
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