MSA
stringlengths
0
1.02k
unaligned_seqs
dict
LLLLEEEEAAAAMMMMVVVVEEEDIVVVLLLLFFFFRRRRSSSSRKRKEEDDLLLLKKKKGGGGDDDDAAAAEAAAPPPPGGGGNNNNLLLLGGGGVVVVCNCNMMLPNNNSGGGGLILIYYFHEEEEMTILDRKRSSSDFFFFPPPL
{ "seq0": "LEAMVEILFRSRELKGDAEPGNLGVCMNGLYEMDSFP", "seq1": "LEAMVEVLFRSKELKGDAAPGNLGVNMNGIYETRSFP", "seq2": "LEAMVEVLFRSRDLKGDAAPGNLGVCLNGLFEIKSFP", "seq3": "LEAMVDVLFRSKDLKGDAAPGNLGVNPSGIHELRDFL" }
PPPPTSSNSSSSKKKKQQQQSSGLDDDDDDDDKKKKQEQQITIIAAAAMMMMVVVASAAAAGGAEEEESSSS---V---Y---R---A---A---A---W---H---Q---N---Y---W---L---G---E---E---L---C---A-M---L---E---R---R---S---I---E---I---I---V---K---M---I---G---Q---A---C---S---H---E---Y---I---A---L---I---D---G---R---A---E---G---L---V---T---L---L--TTTTTTTALLLFIIIIFFFFVIVVKKRKVLVLCCFCCLCLNCNNFFILESEEQQQQRPRRMIMMSSSSGGGGMFFF
{ "seq0": "PTSKQSDDKQIAMVSAESTTLIFVKVCCNFEQRMSGM", "seq1": "PSSKQSDDKETAMVAGESMLERRSIEIIVKMIGQACSHEYIALIDGRAEGLVTLLTTLIFIKLCLCFSQPISGF", "seq2": "PSSKQGDDKQIAMVAGESTTLIFVRVFCNIEQRMSGF", "seq3": "PNSKQLDDKQIAMAAAESVYRAAAWHQNYWLGEELCATAFIFVKLCLNLEQRMSGF" }
KKKKGTVGEEEEGGGGAAAAGGDGDSTDLLLLTTITKKKKDDDDILVICCCCVVGVQRRQLLVLATTTAASAGGGGNNANQPYQEQQESQQQLLLLAAAARVVCTSASAAAAFQQQSSSSHHHHVVVVQLLLWWWWK---
{ "seq0": "KGEGAGDLTKDICVQLAAGNQESLARTAFSHVQWK", "seq1": "KTEGAGSLTKDLCVRLTAGNPQQLAVSAQSHVLW", "seq2": "KVEGADTLIKDVCGRVTSGAYQQLAVAAQSHVLW", "seq3": "KGEGAGDLTKDICVQLTAGNQEQLACSAQSHVLW" }
EEEEFFFFVAVAPPPPYYYYGGGGLILMIIIIQSSSEEEEAVAVSTSTYFYYEEEEVLILEEEQKKKKSSSSGGGGKQKQRKRKFLFLEEEENDNDRRKRIVIVLLLQEEEERERRVTVTGGGGGGGGWWWWDDDDIIIIVIIISSSSDDDDKKKKNNNNV-V-F-F-
{ "seq0": "EFVPYGLIQEASYEVEKSGKRFENRILERVGGWDIVSDKNVF", "seq1": "EFAPYGIISEVTFELEKSGQKLEDRVLEETGGWDIISDKN", "seq2": "EFVPYGLISEASYEIEKSGKRFENKILERVGGWDIISDKNVF", "seq3": "EFAPYGMISEVTYELQKSGQKLEDRVQERTGGWDIISDKN" }
MMYMQQKQFLFLEEEETTTTYYYYAAAMHHHHAAASIIIIIIIIVIVIKRSKAASATRRRLLLLTTTISSSSNNNDLLVLAARASSSRESKEFFMFRRSRIIVIIIIIASSGTSTSSSSASSSARRRRIIIIIVVVRRRRSSQS---H---E---QSSSVSSTT
{ "seq0": "MQFETYAHAIIVKATLTSNLASEFRIIATSSRIIRSSS", "seq1": "MQLETYAHAIIIRARLTSNLASSFRIISSSSRIVRSSS", "seq2": "YKFETYAHAIIVSSRLTSNVRSKMSVISTSSRIVRQST", "seq3": "MQLETYMHSIIIKARLISDLAREFRIIGSAARIVRSHEQVT" }
NDDDIIIIRQRQTAAAIIIIFLFLGGGGWWWWL-L-K-K-N-N-HIHIQEQYRRSRHQHQQQHNSNSNMVLVKKKKMMMGVIIILLLLSSNS-D-DIIIIMMMMYYYYVAAALLLLVAVVQHEHDDDDDEDESGAGILALIIIIGGGGSSNSQQQQNRNR
{ "seq0": "NIRTIFGWLKNHQRHQSMKMVLSIMYVLVQDDSIIGSQN", "seq1": "DIQAILGWIERQQNVKMILSDIMYALAHDEGLIGSQR", "seq2": "DIRAIFGWLKNHQSHHSLKMILNIMYALVEDDAAIGNQN", "seq3": "DIQAILGWIYRQNNVKGILSDIMYALVHDEGLIGSQR" }
SSSSTKLICCCCAAMADDDDAAKKGGGGFFYFMILLEEKKGGGGIITMHHHHAAALTTTV--C-FFFFQQQVYYYYKKKK---V---EDDDDKKKKQQKKEEEEMLLLLRRKNNNNLLLLSSSSKKKAGGGGLLLLPPPPRRRRNNNNLLLVSSSAGGGGFFFFIIVI
{ "seq0": "STCADAGFMEGIHATFQYKDKQEMLNLSKGLPRNLSGFI", "seq1": "SKCADAGFIEGIHATFQYKDKQELRNLSKGLPRNLSGFI", "seq2": "SLCMDKGYLKGTHATCFQYKDKKELRNLSKGLPRNLSGFV", "seq3": "SICADKGFLKGMHLVFVYKVEDKKELKNLSAGLPRNVAGFI" }
AAAASSSSSSSLGGGGVVVVDDDDLLLLGGG-IIIIQQQQDDDERRRRYYYYTSASQQQQPTRSYYYYSSSSMMLMAAAFNNSNFFFFKKKKQQGKDDDDPPPPYYYYEEEELIIIAAAKLIQLIII-AAA-FFF-IIA-PPP-EEE-KKK-CCL-KTKK
{ "seq0": "ASSGVDLGIQDRYTQPYSMANFKQDPYELALIAFIPEKCK", "seq1": "ASSGVDLGIQDRYSQTYSMANFKQDPYEIAIIAFIPEKCT", "seq2": "ASSGVDLGIQDRYAQRYSLASFKGDPYEIAQIAFAPEKLK", "seq3": "ASLGVDLIQERYSQSYSMFNFKKDPYEIKLK" }
DDDDVIVIPPPPFFFFNKNKTTVT---Q---L---A---LLIILVIIIEEEECCCNSNNNAAAATTTTRRRRLMLLRHRHSSSSIIMILMLMNNNNIIILATVTLVLLGGGNLHLYAAAARGGGAAAAFSFF--E-PPPPSSSSGGGTSSSDIVVVGGGGRRRKSSQSDSSMDNNN-A---D---V---A---I---E---S---L---H---E---S---L---Q---E---Y---A---R---N---N---V---E---P---T---A---D---L--
{ "seq0": "DVPFNTLVECSATRLRSILNIALGLARAFPSGSIGRSDD", "seq1": "DIPFKTIIECNATRMHSIMNITVGHAGASPSGSVGRSSNADVAIESLHESLQEYARNNVEPTADL", "seq2": "DVPFNVIIECNATRLRSMLNIVLGLAGAFEPSGSVGRQSN", "seq3": "DIPFKTQLALLIENNATRLHSIMNLTLNYAGAFPSTDVGKSMN" }
DDDDVVVMILLLIIIIQQQQNRNRVVVVCCCCAVAAGGGGKKKKLLLLQQQKEEEETTTTFFFFGGGGRKRRD-DEI-VII-IVF-FFRRRRFFFFKKKKSSSSIIIIQQQQTTTTMMMMILIFDDDDYFYFAART
{ "seq0": "DVIIQNVCAGKLQETFGRDIIFRFKSIQTMIDYA", "seq1": "DVLIQRVCVGKLQETFGKRFKSIQTMLDFA", "seq2": "DVLIQNVCAGKLQETFGRDVIFRFKSIQTMIDYR", "seq3": "DMLIQRVCAGKLKETFGREIVFRFKSIQTMFDFT" }
LLLLLHLLNNNNLLLLEEEETTITEEEELLLLTTTTVFVVRRRRIFIIVVVVTTTAIFFFNVSSKKRKIVAVKKKKRQRRAAAANNNNLLLMFFFFGGGGTKTTGEEENVNNRRGRTTTTIIAAEVKK-E---I--
{ "seq0": "LLNLETELTVRIVTINKIKRANLFGTGNRTIE", "seq1": "LHNLETELTFRFVTFVKVKQANLFGKEVRTIVEI", "seq2": "LLNLEIELTVRIVTFSRAKRANLFGTENGTAK", "seq3": "LLNLETELTVRIVAFSKVKRANMFGTENRTAK" }
TVIIDSDSFFFFYWYYAAAADDDDLLLFAAAAALLLCCCCKKKKFFFFIYVIIPVPAAAARRRRPPFPIKIIAAAARRRRTTTVQQQQGGGGVVVVAAAAASASIVIINNENNNNNAAAAPPIPIVVVTQQQGEEETVVV
{ "seq0": "TDFYADLAACKFIIARPIARTQGVAAINNAPITGT", "seq1": "VSFWADLALCKFYPARPKARTQGVASVNNAPVQEV", "seq2": "IDFYADLALCKFVVARFIARTQGVAAIENAIVQEV", "seq3": "ISFYADFALCKFIPARPIARVQGVASINNAPVQEV" }
TTTTVMIVNNDNPPPAMTTTAAAALLLLPPPPLVIISASSDDDDDDGNS--SL--LG--GLLLLIIIITTTTKKTTLLMLDDDDNNNNQQESVVVLDDDDMMIMFFFFIIIINNNNSSSSGGGGVVTVSAAAPPPPTTVTSNNNVVVVIIIIAAAAEENETTTTEEEE
{ "seq0": "TVNPMALPLSDDSLGLITKLDNQVDMFINSGVSPTSVIAETE", "seq1": "TMNPTALPVADDLITKLDNQVDMFINSGVAPTNVIAETE", "seq2": "TIDPTALPISDGLITTMDNEVDIFINSGTAPVNVIANTE", "seq3": "TVNATALPISDNSLGLITTLDNSLDMFINSGVAPTNVIAETE" }
LLLLGGGGKKHKPPPPGGGGLVVVDYYRSASTLLILLLLLPPPPIILLFFFFFFFFEEEENNNNRRQQPPPPTTIIQKKKSSSAP-PPC-CCL-LLI-IIIITTGGGGDDQDIIIILWIIIVVVDDDDLHLLDDDD
{ "seq0": "LGKPGLDSLLPIFFENRPTQSPCLIIGDILIDLD", "seq1": "LGKPGVYALLPIFFENRPTKSIGDIWVDHD", "seq2": "LGHPGVYSILPLFFENQPIKSPCLITGQIIVDLD", "seq3": "LGKPGVRTLLPLFFENQPIKAPCLITGDIIVDLD" }
TSAT-LL--SS--LL--TT--YY--EE--PP--GA--LL--VV--TT--A---YY--KK--NN--AA--AA--YY--FF--PP--TT--PP--LL--SS--KK--YF--DD--FF--LL--PP-YHHFIVVLWWWWLLLLIIIIAPPAHDHDIIIISSASSSSSAAAARRRRRALRRAAREFHELLLLRRRRLLLLR--RE--DM--MI--MVMMVS---AMMVTTTTSTTSRRRRWWWWQAAKDDDD-HH-GGGGAAAA
{ "seq0": "TYIWLIAHISSARRRELRLREMIVSATSRWQDGA", "seq1": "SLSLTYEPGLVTAYKNAAYFPTPLSKYDFLPHVWLIPDISSARAAFLRLMMTTRWADHGA", "seq2": "ALSLTYEPALVTYKNAAYFPTPLSKFDFLPHVWLIPHIASARLAHLRLMMTTRWADHGA", "seq3": "TFLWLIADISSARRRELRLRDMMVVTSRWKDGA" }
VIVVAASATATT--S-EEEEPPPPRRRRVVIVKKKKTVTTTTTNVVVVASACPPPPFFFFEEKESASSDDDDTVTKKKKKGGGGPPPPKKQKRRRRTTTTNNNNLVLVVTATAASASNTSSSTSLLLLVVTVPPPPAGGAD-EDM-MMF-GGI-IISSST
{ "seq0": "VATEPRVKTTVAPFESDTKGPKRTNLVASSLVPADMFIS", "seq1": "IAAEPRVKVTVSPFEADVKGPKRTNVTANSLVPGS", "seq2": "VSTSEPRIKTTVAPFKSDTKGPQRTNLASTTLTPGEMGIS", "seq3": "VATEPRVKTNVCPFESDKKGPKRTNVTASSLVPADMGIT" }
AAAADNNNSSSSLLLLILLLASAAAAEAELLEEEEE-CC--KK-NNNNPPPPEEEEIIIIDDDDHEEQQQQNDGGDKKKKFYYFDDDDMMMMVVVMQRRQLLLLYYYYNSNNLLLLEDQEKKKKDDDDENNDGGGGNWHYFFFFNNNN
{ "seq0": "ADSLIAAEENPEIDHQDKFDMVQLYNLEKDEGNFN", "seq1": "ANSLLSALECKNPEIDEQGKYDMVRLYSLDKDNGWFN", "seq2": "ANSLLAELECKNPEIDEQGKYDMVRLYNLQKDNGHFN", "seq3": "ANSLLAAEENPEIDQNDKFDMMQLYNLEKDDGYFN" }
KKRKNNNNNQQQAAAKGGGGMLMMEDDDPPPPVITTGGGGSSSSDEEENNNNPPPPLLMMDDDDAAAAYYYYHHHHPMPPPPPPVVVVGGGGGEDDCCCCYYYYNQQQLLLLEEEEATTTLLLLEDDD
{ "seq0": "KNNAGMEPVGSDNPLDAYHPPVGGCYNLEALE", "seq1": "KNQAGLDPIGSENPLDAYHMPVGECYQLETLD", "seq2": "RNQAGMDPTGSENPMDAYHPPVGDCYQLETLD", "seq3": "KNQKGMDPTGSENPMDAYHPPVGDCYQLETLD" }
VIIIKTTKEEEERRRRRRRLPVKPYYYYKKKKQKQHIMMIQQQQPPPPQQQQAAASEEEENNNNDDDDLLLLRRRRLLLLASSSVVVVDDSDP--PD--EQWWQLLLLFYFFDDEELLLLVTNTKLLR
{ "seq0": "VKERRPYKQIQPQAENDLRLAVDPDQLFDLVK", "seq1": "ITERRVYKKMQPQAENDLRLSVDWLYDLTL", "seq2": "ITERRKYKQMQPQAENDLRLSVSWLFELNL", "seq3": "IKERLPYKHIQPQSENDLRLSVDPEQLFELTR" }
EQEEIIVIRRRRTAVVAAAALLLLLLFLLLILT---L---F---Y---T---AAAALLMLLLLLLLLLDDEEFYFFCCMCHHCCTTTTPPPPQQRQPPEEPPPPIIFIIIIISSSSEEEERRRKEEEEKKKKSSSSTREETSSSVVVV
{ "seq0": "EIRTALLLTLFYTALLLDFCHTPQPPIISEREKSTTV", "seq1": "QIRAALLLALLLDYCHTPQPPIISEREKSRSV", "seq2": "EVRVALFIAMLLEFMCTPREPFISEREKSESV", "seq3": "EIRVALLLALLLEFCCTPQEPIISEKEKSESV" }
RRKRSSSSPPPPVVVVDDDDGGGGVVVVVVIVPRHHEEEEDSSSVVVVAAAATNTSLMLLDEDEHHHHYYYY-GGG-VVV-EKQ-EEE-FYI-LLL-KKK-HYH-PPP-NNN-TLT-SSS-AAA-EQQ
{ "seq0": "RSPVDGVVPEDVATLDHY", "seq1": "RSPVDGVVRESVANMEHYGVEEFLKHPNTSAE", "seq2": "KSPVDGVIHESVATLDHYGVKEYLKYPNLSAQ", "seq3": "RSPVDGVVHESVASLEHYGVQEILKHPNTSAQ" }
DHDHHHHHLEQQEPEPIMIMTSTSIIIIGGGGFIYIGGGGIIIILILLDDDDLVLVIIITPPPPGGGAFFFFQQQQRKRKTATT-L-FIIIIGGGGVCVCRRRRLQLQNHNHVVVCEEQERFYFDDDDILLLRRRREEEEHYHHYYYYIIIIVSVS
{ "seq0": "DHLEITIGFGILDLIPGFQRTIGVRLNVERDIREHYIV", "seq1": "HHEPMSIGIGIIDVIPGFQKALIGCRQHVEFDLREYYIS", "seq2": "DHQEITIGYGILDLIPGFQRTIGVRLNVQYDLREHYIV", "seq3": "HHQPMSIGIGILDVTPAFQKTFIGCRQHCEFDLREHYIS" }
SSFSHHRRQQQKIIVVYYYYLLLLEREEPPPPLQLLGGNNWWWFDDDDEEEEIIIIRRRREEERIVILEEQETTSSAAAAQKKKVVAAYYYLKNNNIFFFYYYLKKKKFLLLPPPPKKKKAATTVVVV
{ "seq0": "SHQIYLEPLGWDEIREIETAQVYKIYKFPKAV", "seq1": "SHQIYLRPQGWDEIREVETAKVYNFYKLPKAV", "seq2": "FRQVYLEPLNWDEIREIQSAKAYNFYKLPKTV", "seq3": "SRKVYLEPLNFDEIRRLESAKALNFLKLPKTV" }
QNNNTHHQEEEEQQQQIIIIFFFFTQQIVVVVIVVVEEEEGGGGLLLLSTTTLLLLEEEEKRRREAAATTTTGEEESNNNLLLLPAAAATTTDDDDDDDDQMMMQQQQIVVAVLVVMMMMTAAAMLMLRKKKKKKKQQQQYLLLKRKKAAAA--S---D---L---W---R---V---I---W---F-
{ "seq0": "QTEQIFTVIEGLSLEKETGSLPADDQQIVMTMRKQYKA", "seq1": "NHEQIFQVVEGLTLERATENLATDDMQVLMALKKQLRA", "seq2": "NHEQIFQVVEGLTLERATENLATDDMQVVMAMKKQLKASDLWRVIWF", "seq3": "NQEQIFIVVEGLTLERATENLATDDMQAVMALKKQLKA" }
LLKIFFFFQQQQLLLLKKKKFLYYAAAALLLLATTTLLLLEEEEQLMPQQQQVIITEEEEIII-RRRQDDDDVVAADDDETATTCCCATAAAFFFFTTTTYYRYVLLLVVVVQQRRNPPPAVSAFFLY
{ "seq0": "LFQLKFALALEQQVEIRDVDTCTFTYVVQNAF", "seq1": "LFQLKLALTLELQIEIRDVDACAFTYLVQPVF", "seq2": "KFQLKYALTLEMQIEIRDADTCAFTRLVRPSL", "seq3": "IFQLKYALTLEPQTEQDAETAAFTYLVRPAY" }
TVVVYFFYNNNNTDDDAAAAEEEEMSTTKKKKGGGGPPPPRRRRRRRRKKKKFFFFFFFFSTTTYYYYLFFFGGGGGGGGEEEESSSSAAAATTTAYYYHSKRPPPPPPSSGEEEERNNNKKKKALAT
{ "seq0": "TYNTAEMKGPRRKFFSYLGGESATYSPPERKA", "seq1": "VFNDAESKGPRRKFFTYFGGESATYKPSENKL", "seq2": "VFNDAETKGPRRKFFTYFGGESATYRPSENKA", "seq3": "VYNDAETKGPRRKFFTYFGGESAAHPPGENKT" }
RRRREEEELLILVVIVYYYYAAPAIVVIGGGGSTVTLLFLVVVIHHQRFFMFAASSH---AAKAPPPPMMQMDDDDGGAGQQSQLLLLNNNNKRRRYYYYLLLLDDEDEEEESSSSTTTTMMMMRRKRGGGAILLLTTTTNNNNMMTKPPPPDDDEDDDCQQQQVVAVAACC
{ "seq0": "RELVYAIGSLVHFAHAPMDGQLNKYLDESTMRGITNMPDDQVA", "seq1": "RELVYAVGTLVHFAAPMDGQLNRYLDESTMRGLTNMPDDQVA", "seq2": "REIIYPVGVFVQMSKPQDASLNRYLEESTMKGLTNTPDDQAC", "seq3": "RELVYAIGTLIRFSAPMDGQLNRYLDESTMRALTNKPECQVC" }
NNNNDDDDKKKKNNNVVVVVYYYYRHRRVAAASAASAAAAQKKQTTTTLLLLVTTVGGGGEEEESSSSDDDDLLLLAAARPPPPAAAAKQQKPPP-TMM-SSS-EEE-IIM-RRR-EEE-HSS-KKH-
{ "seq0": "NDKNVYRVSAQTLVGESDLAPAKPTSEIREHK", "seq1": "NDKNVYHAAAKTLTGESDLAPAQPMSEIRESK", "seq2": "NDKNVYRAAAKTLTGESDLAPAQPMSEMRESH", "seq3": "NDKVVYRASAQTLVGESDLRPAK" }
MSSAAAASLVVIPPPPAAAHVVVLMNNMIVVIRRTQEKNEAVVAKRRPGGGGQ--QP--PT--SE--QG--AE--AT--TE--ER--KL--LY--YT--PV--VE--KG--GV--MI--II--ID--DM--IV--VC--CI--IG--GR--RP--PQ--QR--RL--LF--LI--VY--YE--EK--KL--LF--FLLLLSSSSKKKKRRRRYNNG-VV--II--MM--GG-HHQHFLLYYYYYYYYYQTNQFFFFEEEEAAAAKKEKKKKKPPPPNNNNGEEG-VV--LI--EE--KK--LI--RR--EE--FF--LL-ALLADAADTTNT
{ "seq0": "MALPAVMIREAKGQPTEGETERLYTVEGVIIDMVCIGRPQRLFIYEKLFLSKRYHFYYQFEAKKPNGADT", "seq1": "SAVPAVNVRKVRGLSKRNVIMGHLYYTFEAKKPNEVLEKLREFLLAT", "seq2": "SAVPAVNVTNVRGLSKRNVIMGQLYYNFEAEKPNEVIEKIREFLLAN", "seq3": "ASIPHLMIQEAPGQPSQAATEKLYPVKGMIIDIVCIGRPQRLLVYEKLFLSKRGHYYYQFEAKKPNGADT" }
AAAAYYYYTEEELLLLKKQKRRRRIRIREEPEILILVVVVMMMMEEEEPPPPLLILGYGGEEQETTGTIIIIWFPWFFFFRKRVKKNKRRKR---V---I---I---A---N---H---Q---G---LLLLLYYFYYYYYEEEEYYFYVLIIQQVQHHHHGGRGLMLLVV-VDD-DEE-EST-KLLLL
{ "seq0": "AYTLKRIEIVMEPLGETIWFRKRLYYEYVQHGLVDESL", "seq1": "AYELKRRELVMEPLYETIFFKKRLYYEYLQHGMVDETL", "seq2": "AYELQRIPIVMEPIGQGIPFRNKLFYEFIVHRLL", "seq3": "AYELKRRELVMEPLGETIWFVKRVIIANHQGLLYYEYIQHGLVDEKL" }
EEEEFFFFVVAVMLLMNNNKDDDDAAQMFFFFEEDETTSTIIIIYYYYFFFFACCAYFYYSEENSSSSKKKKGTTTTSTTSSNSLLLLQLLQIIIILLLLNSRSVVAVMMMVGGGGTMMMVLLVIIVIKKRKEKEESAASGGGGEDEETPPTIIIILLLLVVVV
{ "seq0": "EFVMNDAFETIYFAYSSKGTSLQILNVMGTVIKESGETILV", "seq1": "EFVLNDAFETIYFCFESKTSSLLILSVMGMLIKKAGDPILV", "seq2": "EFALNDQFDSIYFCYESKTTNLLILRAMGMLVREAGEPILV", "seq3": "EFVMKDMFETIYFAYNSKTTSLQILSVVGMVIKESGETILV" }
DNDDFFFFLLLLVGVVFFFFVVVVPYYYDDEDNQQQRRRRYYYYCACCIIIIEDDDNSGY-L---A---S---A---P---A---G---C---S---L---L---K---Q---P---M---L---L---R---E---L---F---S---C---K---V---T---T---V---S---W---S---Q---F---A---G---P---H---S---D---E---L---L--S-SAE-EESEACRRHRIIIIVLLLGGGTTTTAVSAAYFFFEEEEAAAATSTTLRLLIIIIKKKKEEEAQNNNIIIILVLLRKKKTEASFFFFKRRRNSNNDVSS
{ "seq0": "DFLVFVPDNRYCIENSESRIVGTVYEATLIKEQILRTFKND", "seq1": "NFLGFVYDQRYAIDSLASAPAGCSLLKQPMLLRELFSCKVTTVSWSQFAGPHSDELLERILGTSFEASRIKENIVKEFRSV", "seq2": "DFLVFVYEQRYCIDGSEAHILGTAFEATLIKENILKAFRNS", "seq3": "DFLVFVYDQRYCIDYAECRILTAAFEATLIKANILKSFRNS" }
SGSGCIIIDDDDPSPPLVLIVVVVKKKKGGGGCLCLLFLYVVVLDEDDKKKKQLLLGAAAMMLLGGGGGGGGEEEESSSSEEEEHEHHSSSAPPPPFPSADDDDVVVVWYYYSAAASSSSYFYYEDDDTTTTNSQNQNQQLLLL
{ "seq0": "SCDPLVKGCLVDKQGMGGESEHSPFDVWSSYETNQL", "seq1": "GIDSVVKGLFVEKLAMGGESEESPPDVYASFDTSNL", "seq2": "SIDPLVKGCLVDKLALGGESEHSPSDVYASYDTQQL", "seq3": "GIDPIVKGLYLDKLALGGESEHAPADVYASYDTNQL" }
RRRRKKKKEEEESTSSKDDDPPPPSSSSEEEELLLLLLLLPPPPGGGGTTTTVVVVEEEEAAAAEEEDHHHHSGSSEQDEKKRKSASSTSTTNNKNYHYYTATAMLLLTTTTEDEDTTTTPPPPVVVVLLLLLLLL
{ "seq0": "RKESKPSELLPGTVEAEHSEKSTNYTMTETPVLL", "seq1": "RKETDPSELLPGTVEAEHGQKASNHALTDTPVLL", "seq2": "RKESDPSELLPGTVEAEHSDRSTKYTLTETPVLL", "seq3": "RKESDPSELLPGTVEADHSEKSTNYALTDTPVLL" }
TCTCRRRRASASTTTTDDDDLLLLPPPPPPYPPEPEIIVVAAAAGGDGRRRRVFVFGGGGTPSPGGGGVAVANDNDVLLLEDEDYHYHVVIVILLLEKKRLLLLTTATPPPPCICIGAGGSDDDKKKKMALAVAVVKKKKDEDEHNNNKRKRFFFFDGDGKKKK
{ "seq0": "TRATDLPPPIAGRVGTGVNVEYVIELTPCGSKMVKDHKFDK", "seq1": "CRSTDLPPEIAGRFGPGADLDHVLKLTPIADKAAKENRFGK", "seq2": "TRATDLPYPVADRVGSGVNLEYILKLAPCGDKLVKDNKFDK", "seq3": "CRSTDLPPEVAGRFGPGADLDHVLRLTPIGDKAVKENRFGK" }
PPPPAAAKAAAAGHGGSSSSLLLLKSRKSSSPSSSSCLCCWWWWGAGTKKKKNNVNLLLLLLVLAVAAGGGGYFYYQWQQQ--AM--MM--MP--PFEFFVVVV---L---I---V---G---V---L---G---Y---R---A---E---I---V---L---F---Y---S---G---Q---C---P---V---I---E---N---P---T---K---F---R---T---P---G---D---E---K---D---R---R---P---A---Y---L---V---MGAGGESEEGGGGAKKAATAAKKKKRRRRSSSSTTTTPPPPPPPPLLLL
{ "seq0": "PAAGSLKSSCWGKNLLAGYQQMMPFVGEGAAKRSTPPL", "seq1": "PAAHSLSSSLWAKNLLVGFWEVASGKTKRSTPPL", "seq2": "PAAGSLRSSCWGKVLVAGYQFVGEGKAKRSTPPL", "seq3": "PKAGSLKPSCWTKNLLAGYQAMMPFVLIVGVLGYRAEIVLFYSGQCPVIENPTKFRTPGDEKDRRPAYLVMGEGAAKRSTPPL" }
AAAASSFFFLFFMASSNNNNDDDDASAAIILLEEEELLLIDDDDELVVSSSSLLLLKRKRVVIVGGGGEEEEQQQQDDDDNNNNLLQLKSDDENKKHQEH--I---R---D---D---K---A---L---Q---G---M---I-IVIIAAAAAAAAFCCCQRQQEEDDTGTEPPPPEESSVVAAKKKSKKKKDDDDDDGGKKKKSASS
{ "seq0": "ASFMNDAIELDESLKVGEQDNLKEHIAAFQETPEVKKDDKS", "seq1": "ASLANDSIELDLSLRVGEQDNLSNQVAACREGPEVKKDDKA", "seq2": "AFFSNDALELDVSLKIGEQDNQDKEIRDDKALQGMIIAACQDTPSAKKDGKS", "seq3": "AFFSNDALEIDVSLRVGEQDNLDKHIAACQDEPSASKDGKS" }
QKKKKKKKLLLLTN--MM--VI--PP--LL--LL--KH--LL--FL--TT--LY--VV--TS--IV--EE--VV--QQ--DA--IL--LY--NT--WW--GG--GG--DD--KK--PP--EE--EE--KE--VV--FF--TP--
{ "seq0": "QKLTMVPLLKLFTLVTIEVQDILNWGGDKPEEKVFT", "seq1": "KKLNMIPLLHLLTYVSVEVQALYTWGGDKPEEEVFP", "seq2": "KKL", "seq3": "KKL" }
VIVVLLLLGGGGLLLLGGGGVVVIEEEEQEQKFFFFWWWWDQDDQQQNLLLLEDEESSSSPPPPFFFFVVIVGGGGGGGGIVVVYYYYIIILIIIVVGGGDTDDRRRKPRPPDDDTGSGGMQMMYYYYENKKLILL
{ "seq0": "VLGLGVEQFWDQLESPFVGGIYIIVDRPDGMYEL", "seq1": "ILGLGVEEFWQQLDSPFVGGVYIIGTRRDSQYNI", "seq2": "VLGLGVEQFWDQLESPFIGGVYIIGDRPDGMYKL", "seq3": "VLGLGIEKFWDNLESPFVGGVYLVGDKPTGMYKL" }
DEEECCCCLAALVATLILLIKKKKGGGGSSTSLLLLPPPPNNNNTTTTHHHHDEDDPPPPVFMMLLLLRRRRAAAATTSTVVVVYFFYEEEEVVVVKKKKDDLDVVVVVLVVRRRREDEEFFFFEEEDTAASKEEE
{ "seq0": "DCLVIKGSLPNTHDPVLRATVYEVKDVVREFETK", "seq1": "ECAALKGSLPNTHEPFLRATVFEVKDVLRDFEAE", "seq2": "ECATLKGTLPNTHDPMLRASVFEVKLVVREFEAE", "seq3": "ECLLIKGSLPNTHDPMLRATVYEVKDVVREFDSE" }
FFFFEAET-SST-KTT-VVI-PSS-EGD-HHH-SSS-VVV-FFF-TTV-HCI-III-LLL-SSS-EHK-DDD-LYL-PPP-ASS-KKK-ATT-PPP-KKK-AAG-NDN-AAQ-LLL-AAA-IIIGNANFFFF
{ "seq0": "FEGF", "seq1": "FASKVPEHSVFTHILSEDLPAKAPKANALAINF", "seq2": "FESTVSGHSVFTCILSHDYPSKTPKADALAIAF", "seq3": "FTTTISDHSVFVIILSKDLPSKTPKGNQLAINF" }
EDEEAAAATTTTLLLLAAAALLLFPPPPQQQQIVVVPPSSEEEAVTVV--P-VVIIKKKKVVVVNNFNTTTAGQTQKKKKEEEETSTTYYGGMMMMEEEEAPPPDDDD--YFRRRRLLLLEEEEKKGGAAAAVVKK
{ "seq0": "EATLALPQIPEVVKVNTGKETYMEADRLEKAV", "seq1": "DATLALPQVPETVKVNTQKESYMEPDRLEKAV", "seq2": "EATLALPQVSEVPIKVFTTKETGMEPDYRLEGAK", "seq3": "EATLAFPQVSAVIKVNAQKETGMEPDFRLEGAK" }
LLLLPPRPRRERVLVLGGGGEDEDAVVVAAAAVLVVAAAAVIVITAAAAAPSVVVV-MVMAAAAEVPVLLLHRKRKGDGDNNNRDDDDMLMLVIIIAAAAIVLVYLILIIIILLLLEKEKNNCNTTTTLL-L
{ "seq0": "LPRVGEAAVAVTAVAELRGNDMVAIYILENTL", "seq1": "LPRLGDVALAIAAVMAVLKDNDLIAVLILKNTL", "seq2": "LREVGEVAVAVAPVVAPLRGNDMIALIILECT", "seq3": "LPRLGDVAVAIASVMAVHKDRDLIAVLILKNTL" }
--M---I---L---E---K---A-DDDNDDEDGG-GLMMMPPPPGGSGVVVTNNNNGGGGCCC-LLLLPPSRLLLLPPPPVVITTTTQAAAASSSSRRRRQQLMAAAAEEDEKKKKIVILKKKKSTSSHHAQLLLLVVAVKKKKDDNDNSNNSASSTTVTSSSSTQDQVVVVYYTYLLMLGGGGHHSHIIIIVIVVSSSS
{ "seq0": "DDGLPGVNGCLPLPVTASRQAEKIKSHLVKDNSTSTVYLGHIVS", "seq1": "DDGMPGVNGCLPLPVTASRQAEKVKTHLVKDSATSQVYLGHIIS", "seq2": "MILEKADEMPSVNGCLSLPITASRLADKIKSALAKNNSVSDVTMGSIVS", "seq3": "NDGMPGTNGLRLPTQASRMAEKLKSQLVKDNSTSQVYLGHIVS" }
AAAAAAAADDDDDDDDPPPPMVMMGAGGVVVVTTTTVILLGGGGSNSSGGGGFFFFYYYYAAAAQTTTKKRRKKKKSSSNTTTTRRRRFFFFGGGGIIIIIIIILLLLIIIILHLLHQHHQQVVSSESLLLLEEAALLLLYYYYTTHKDDEEVVVVFFFVWWWWAAAAVVFFEDEE
{ "seq0": "AADDPMGVTVGSGFYAQKKSTRFGIILILHQSLELYTDVFWAVE", "seq1": "AADDPVAVTIGNGFYATKKSTRFGIILIHQQSLELYTDVFWAVD", "seq2": "AADDPMGVTLGSGFYATRKSTRFGIILILHVELALYHEVFWAFE", "seq3": "AADDPMGVTLGSGFYATRKNTRFGIILILHVSLALYKEVVWAFE" }
MMMMPPPPFLLLSSSTEEEENNNNIIIISSSSKSSHTTLTKTTKGAEGIVVILLLLLLLLLFFLTKKKFIIFRSSCYYYYRRRRTEEIAAAADDDDPAAAYYYYWWWWKRRKIIIVKKKKRCCRLRRLKKKK
{ "seq0": "MPFSENISKTKGILLLTFRYRTADPYWKIKRLK", "seq1": "MPLSENISSTTAVLLFKISYREADAYWRIKCRK", "seq2": "MPLSENISSLTEVLLFKISYREADAYWRIKCRK", "seq3": "MPLTENISHTKGILLLKFCYRIADAYWKVKRLK" }
LLLLIMVIQQQQQQQQLLLLLLLMSSSSRSSSDDDDAAAADDDDEHHHLLLLMPTTDDDDLLMIGGGGEEEEYYYYGGGGVIIIKPKKTKTTGAGGSSSSLIIIFFFFAAAANNNNQQQQIVKIPPPPEAEE
{ "seq0": "LIQQLLSRDADELMDLGEYGVKTGSLFANQIPE", "seq1": "LMQQLLSSDADHLPDLGEYGIPKASIFANQVPA", "seq2": "LVQQLLSSDADHLTDMGEYGIKTGSIFANQKPE", "seq3": "LIQQLMSSDADHLTDIGEYGIKTGSIFANQIPE" }
SASSDDDDGGGGVIVVQQQQQSQQPPPPEEEE-K---Y---S---E---N---C---K---T---T---H---S---E---I---K---V---T---R---V---A---A---V---D---S---K---L--
{ "seq0": "SDGVQQPE", "seq1": "ADGIQSPEKYSENCKTTHSEIKVTRVAAVDSKL", "seq2": "SDGVQQPE", "seq3": "SDGVQQPE" }
FFFFVIII-V--L-GGIIIITIVTDDDDEEEENGKKRRRRLLLLYYYYAASASSSSNNNNDNNDAEAAQQQQNDDDLLLLTRRTTVVVNSSSMMLLSRRSIIIIGGGGVIIVDDDDVIIIKQQKAAAAPPPP
{ "seq0": "FVLITDENRLYASNDAQNLTTNMSIGVDVKAP", "seq1": "FIVIIDEGRLYASNNEQDLRVSMRIGIDIQAP", "seq2": "FIGIVDEKRLYSSNNAQDLRVSLRIGIDIQAP", "seq3": "FIGITDEKRLYASNDAQDLTVSLSIGVDIKAP" }
KKKKGGGGVVVVVVVLLLLLCMCCLLLLQQQQLLLLAAALVVVVAAAADDDDRKKKHHHHKKKKLFLFEEEEDDDDPPPPSMQMPPPITTKTESESGGSGMMMTYYYYSSASSASAQDQDDDDDKK-KGGGGWYWWGGGGFMFMRRRRAAAA
{ "seq0": "KGVVLCLQLAVADRHKLEDPSPTEGMYSSQDKGWGFRA", "seq1": "KGVVLMLQLAVADKHKFEDPMPTSGMYSADDKGYGMRA", "seq2": "KGVVLCLQLAVADKHKLEDPQPKESMYASQDGWGFRA", "seq3": "KGVLLCLQLLVADKHKFEDPMITSGTYSADDKGWGMRA" }
RRRKPSSPLLLLRRRREESEKKKQIMMILLILVVIIKKKQEEEEVVVVWWWWAAVSAVVVKKKRVVVVDDDDTTTTLLLLHNNNEEEEEEEEQAQQGGGGSSASKKKKVVTVSSSSHHHHRHRRPPPPAESAKKKKPPPPKKKKAAAAKASA
{ "seq0": "RPLREKILVKEVWAAKVDTLHEEQGSKVSHRPAKPKAK", "seq1": "RSLREKMLVKEVWAVKVDTLNEEAGSKVSHHPEKPKAA", "seq2": "RSLRSKMIIKEVWVVKVDTLNEEQGAKTSHRPSKPKAS", "seq3": "KPLREQILIQEVWSVRVDTLNEEQGSKVSHRPAKPKAA" }
NKNNSSASWWWWKKKKFFFFTNTTRRRRFFFFGGGGGGGGKKKKIIIIPPPPGGGGAAMSSNNNKDKEFLFFRRRRLLLLMMMMASSSQNQNATVA-G--FFFFKKKKWWWWLLLLYEYYILIIQQQQLLLL
{ "seq0": "NSWKFTRFGGKIPGASKFRLMAQAFKWLYIQL", "seq1": "KSWKFNRFGGKIPGANDLRLMSNTGFKWLELQL", "seq2": "NAWKFTRFGGKIPGMNKFRLMSQVFKWLYIQL", "seq3": "NSWKFTRFGGKIPGSNEFRLMSNAFKWLYIQL" }
EQQDRRRRGGGGIIITFFFFAAAARNRNSSNQMMMMGGGGLLLLRRRRTAAASSSSMMMIVVVGNNNNGGGGRRKQAASAPPPPSSSDVVVVHHHHMMMIHHHHTTTSGGGAVVVVHQQQPPPPYYYYLLLSNNNAVVVVIIIIFFFFEEEE
{ "seq0": "ERGIFARSMGLRTSMVNGRAPSVHMHTGVHPYLNVIFE", "seq1": "QRGIFANSMGLRASMVNGRAPSVHMHTGVQPYLNVIFE", "seq2": "QRGIFARNMGLRASMVNGKSPSVHMHTGVQPYLNVIFE", "seq3": "DRGTFANQMGLRASIGNGQAPDVHIHSAVQPYSAVIFE" }
WWWWILIIRRRRLLLLILMLHHHHLLLLQQQQSSSGVVFVIIILCLGLDDDDDEEEFFFFEEEEPPPPHHHHAAAAT-TPGGGGPPPPWWWWTTTTKKKKFFFFQHQHVVAVGGGGWWWWPPPPMVMMSSSSVVCCFYFYLLLLCCACDDDK
{ "seq0": "WIRLIHLQSVICDDFEPHATGPWTKFQVGWPMSVFLCD", "seq1": "WLRLLHLQSVILDEFEPHAGPWTKFHVGWPVSVYLCD", "seq2": "WIRLMHLQSFIGDEFEPHATGPWTKFQAGWPMSCFLAD", "seq3": "WIRLLHLQGVLLDEFEPHAPGPWTKFHVGWPMSCYLCK" }
LLLLTTTTNNNNIIIIVVLVSSSSEEEQEKQKIILIVVIVEEEEFFFFIVIVFFFFTTETVIVIPPPPKKKKQQYQCCSCMMMMNNNNEEEEVVVMYYHYPPPPYYTYPPPPVSSTGGGGDDDATNNNKRKRLLLLLLLLRRRRAATAFFTL
{ "seq0": "LTNIVSEEIVEFIFTVPKQCMNEVYPYPVGDTKLLRAF", "seq1": "LTNIVSEKIVEFVFTIPKQCMNEVYPYPSGDNRLLRAF", "seq2": "LTNILSEQLIEFIFEVPKYSMNEVHPTPSGDNKLLRTT", "seq3": "LTNIVSQKIVEFVFTIPKQCMNEMYPYPTGANRLLRAL" }
QQQQIMIIYYYYRRRRVVVVLLLLQNNNHNNHQLAHGGGGVTTTYYFYTTTTNEEETVVIQEQQVVVVVVVVLVIVKQKKQQQQEEEENNNNFYYFVIIIEGGGNNNNMIMMPPPPGGGGTTTTGGGGAARAGGGGPEPPLLLLLFLLRRRR
{ "seq0": "QIYRVLQHQGVYTNTQVVLKQENFVENMPGTGAGPLLR", "seq1": "QMYRVLNNLGTYTEVEVVVQQENYIGNIPGTGAGELFR", "seq2": "QIYRVLNNAGTFTEVQVVIKQENYIGNMPGTGRGPLLR", "seq3": "QIYRVLNHHGTYTEIQVVVKQENFIGNMPGTGAGPLLR" }
AAAAQKKQD-NNKRKKG-GGSNTTDQEDWWWWGRHGEGEEPPPPSSSSTTTTKRRKRRRRHYHHSASSGGDGQQQSNSNN-VI--LI--MH--SS--DD--VV--GE--EE--LL--RC--VT-VVVVSNSS
{ "seq0": "AQDKGSDWGEPSTKRHSGQNVS", "seq1": "AKRNQWRGPSTRRYAGQSVLMSDVGELRVVN", "seq2": "AKNKGTEWHEPSTRRHSDQNIIHSDVEELCTVS", "seq3": "AQNKGTDWGEPSTKRHSGSNVS" }
PPPPTSTTRRRRGNGGAAAAPSPSFFFFRNRNAAAAKSKKFFFFIIIIRQRQYYYYVIVVAEPEDDDDVVVVLLLLSAAALLLLPPPQVAAADDDDEKKKAAAAGGGGVLVNYFYFPPPPRQRRAAAA
{ "seq0": "PTRGAPFRAKFIRYVADVLSLPVDEAGVYPRA", "seq1": "PSRNASFNASFIQYIEDVLALPADKAGLFPQA", "seq2": "PTRGAPFRAKFIRYVPDVLALPADKAGVYPRA", "seq3": "PTRGASFNAKFIQYVEDVLALQADKAGNFPRA" }
LIIINNSNWWWWENDDGGGGTITTRRRRLLLITMTTDDNDDNDDAAAAHHHHTTTTMVIMSALCAAAAPPPAYCCCYFWYFFFFQQQQHHHHFDNDPPPTVVVVIMMMAAAAQRRERRRRKMMMTVVILVVVQEEERRRRDDDDPPPPRRRR
{ "seq0": "LNWEGTRLTDDAHTMSAPYYFQHFPVIAQRKTLQRDPR", "seq1": "INWNGIRLMDNAHTVAAPCFFQHDPVMARRMVVERDPR", "seq2": "ISWDGTRLTNDAHTILAPCWFQHNPVMARRMVVERDPR", "seq3": "INWDGTRITDDAHTMCAACYFQHDTVMAERMIVERDPR" }
QKQQFWWWLLLLNNNNVTTSLLIIIIIIQQQQVVLLTYYYEDKRSDDDLLLLQREEVIIIGGGGTTTTSANKQQQQNNDNPAPPFFFFDDHHLKKKVVVILLLLFFFFWLLLR-RREASSVIV-AAA-EAVVLMRMQRNNAAHAILLLLMMMEKKKAAETSSSC
{ "seq0": "QFLNVLIQVTESLQVGTSQNPFDLVLFWREVAELQAILEAS", "seq1": "KWLNTLIQVYDDLRIGTAQNAFDKVLFLAIAAMRALMKAS", "seq2": "QWLNTIIQLYKDLEIGTNQDPFHKVLFLRSVAVRNHLMKES", "seq3": "QWLNSIIQLYRDLEIGTKQNPFHKILFLRSVMNALMKTC" }
LLLLEQDENTTTVVVLQKKKMMMMHHHYYYYFDDDDIV-ARK-KEK-EYY-EGG-GKK-KKK-SII-IED-DLL-LLL-LPP-PFF-IQQQQGGGGGGGGEEEERRRRAAAACVVVDDDATYYYPPPPSSTSLFMVIVIIRRRRE-EED-DDVVVVGGGGFYFF
{ "seq0": "LENVQMHYDIREYGKKIELLPFQGGERACDTPSLIREDVGF", "seq1": "LQTVKMHYDVKKYGKKIDLLPFQGGERAVDYPSFVRVGY", "seq2": "LDTVKMHYDQGGERAVDYPTMIREDVGF", "seq3": "LETLKMYFDAKEEGKSIDLLPIQGGERAVAYPSVIREDVGF" }
GGGGAAAAMMLMEQEEGDGD--Y---T---V---R---S---Q-QEEEQQQQGGGARRKRLLLLSCACLLLLGGGGIIIIAKVKSTTTIFIFVVVVSASAFFFFGGGGGSSS--A-KKNRNNNNEKEQIIIILLLLKKKKAAKAEEEEL---E---W---R---A---CSRTWWWWVVVVRRR-PPP-MMM-
{ "seq0": "GAMEGQQGRLSLGIASIVSFGGKNEILKAELEWRACWVRPM", "seq1": "GAMQDEQGRLCLGIKTFVAFGSKNKILKAESWVRPM", "seq2": "GALEGYTVRSQEQGKLALGIVTIVSFGSANNEILKKERWVRPM", "seq3": "GAMEDEQARLCLGIKTFVAFGSRNQILKAETWV" }
NNNSEEEEGGGG-III-RRK-AAA-QQQ-LLLMEEQVVVVDDDDSSLSVVVVAAAVKRRKEEEDCCCCTNNNRRRRFFFFVIIVVTTVTTTTFFFFAPPSAAAATTTTIFFVSSSKMMMFDDDDIKKKGGGGALVVSGGSLMML
{ "seq0": "NEGMVDSVAKECTRFVVTFAATISMDIGASL", "seq1": "NEGIRAQLEVDSVARECNRFITTFPATFSMDKGLGM", "seq2": "NEGIRAQLEVDLVARECNRFITTFPATFSMDKGVGM", "seq3": "SEGIKAQLQVDSVVKDCNRFVVTFSATVKFDKGVSL" }
IIILVVAADDDDLILLGAGKRSRRSDTTILLLAAAA-N---A---L---L---V---F---A--LLLLMMIMKKRRASAA-N---N--HFYYMLMMAAAASSAARNRRNQNNRKR-SAVAPPPPKRKKLLLLLLRRVIVVYWYYIVIII-IIL-LFK-EER-RRG-GGH-HHT-TTFFFF
{ "seq0": "IVDLGRSIALMKAHMASRNRSPKLLVYIILKRGHTF", "seq1": "IVDIASDLANALLVFALMKSNNFLASNQKAPRLLIWVF", "seq2": "IADLGRTLALIRAYMAARNRVPKLRVYIILERGHTF", "seq3": "LADLKRTLALMRAYMAARNAPKLRVYIIFERGHTF" }
ETSTPPPPLVMIGVGGIIIIQQQK-IIL-EEQ-EES-ITTCCCCEEEDIMIVTTTTKKKKDDDDEPEQLLLLGGGGKKKKDEDDS---AVTIFFFFLLLLGGAGAAFESRRRAALPEDEDYYYYDDDDLLLL--I-Q-QQV-VVA-VMLLLV
{ "seq0": "EPLGIQCEITKDELGKDSAFLGASAEYDLQVAL", "seq1": "TPVVIQIEEICEMTKDPLGKEVFLGARADYDLL", "seq2": "SPMGIQIEETCEITKDELGKDTFLAFRLEYDLIQVVL", "seq3": "TPIGIKLQSTCDVTKDQLGKDIFLGERPDYDLQVMV" }
NNNGVYVIVIVLEVEATTTNQRHRSSSSEEEE-LLLVVVFKKKKEEEKEEEEDDDDVTV-TSSAVVVVLVLVPGPPKRKLYYYFRRRRMMMMDNDDKKKRLLLLAAANWWWWCAALKKKKTTTTRRRRAKAAKKKKMTMQRRRKYYYEKKKYFFFLLILIMMMFITLFGGGGGGGG
{ "seq0": "NVVETQSEVKEEDVTVLPKYRMDKLAWCKTRAKMRYKFLMIGG", "seq1": "NYIVTRSELVKEEDTSVVGRYRMNKLAWAKTRKKTRYKFIMTGG", "seq2": "NVVETHSELVKEEDVSVLPKYRMDKLAWAKTRAKMRYKFLMLGG", "seq3": "GILANRSELFKKEDAVVPLFRMDRLNWLKTRAKQKEYLIFFGG" }
GGGRRRVAPASSSSTTDDNDFFFFGGGGLLLLHNNNRRRLWWWWTTISIIVVPPSKKKKKYYYYGGGGVVVVLPLLGGGGFFFFHHHKLLLLYYYHCCCCGGGNLLLIEEQQQQEENNSNFFFFILLLILIMDDDNRRKKTT-TTTTR
{ "seq0": "GRPSDFGLHRWTIPKYGVLGFHLYCGLEQNFIIDRTT", "seq1": "GRASDFGLNRWTIPKYGVPGFHLYCGLEQNFLLDRTT", "seq2": "GVSTNFGLNRWIVSKYGVLGFHLYCGLQESFLIDKT", "seq3": "RASTDFGLNLWSVKKYGVLGFKLHCNIQENFLMNKTR" }
VTTVQQQQSCGCDDDDAASVTDDTVVVLGAAGHHHHGGGRDDDVYYYYQKQQEEEEK-KNVIVKNNNNYYYYQEEEVVVVKKKKGGAGVVLLLLLLKNEYDNNDEEEDAAAAGGGGAAAA-SS-YFLYRRRWCFCCGRRGGGGGKGGLGGGGNNNNFFFLLLLLTTLTPPPSAAAA
{ "seq0": "VQSDATVGHGDYQEKVNYQVKGVLKDEAGAYRCGGKGNFLTPA", "seq1": "TQCDADVAHGDYKEINYEVKGVLNNEAGASFRFRGGGNFLTPA", "seq2": "TQGDSDVAHGDYQEKVNYEVKALLENEAGASLRCRGGGNFLLPA", "seq3": "VQCDVTLGHRVYQENKNYEVKGLLYDDAGAYWCGGLGNLLTSA" }
EE-DHH-HYF-F-L-M-L-L-I-I-D-D-L-LVI-ISTSTPPTPEEEERRRRE-E-V-V-N-N-LLLLLLFITTTTTTTTNSNSGGGGAAAAEEEEETETIVIVTTTTLLLLWFWFVVLVAAAAEQEQGGGGEEEEDEDEGAGA
{ "seq0": "EHYVSPEREVNLLTTNGAEEITLWVAEGEDG", "seq1": "EHFLLIDLITPERLLTTSGAETVTLFVAQGEEA", "seq2": "STEREVNLFTTNGAEEITLWLAEGEDG", "seq3": "DHFMLIDLITPERLITTSGAETVTLFVAQGEEA" }
LVL-TTTTPPPEMMTATTT-SSENMMLMIRRKQQQQPPSPIIILTTTTIIIIDDDDRRRKYYYYDSNDAESSAAASKKKKTTTESMIMLLAGEEEETTTTNNNNYYYYRSRRHHHHFFFFAAPASSASWWWW
{ "seq0": "LTPMTSMIQPITIDRYDAAKTSLETNYRHFASW", "seq1": "VTPMTSMRQPITIDRYSEAKTMLETNYSHFASW", "seq2": "LTPTTELRQSITIDRYNSAKTIAETNYRHFPAW", "seq3": "TEANMKQPLTIDKYDSSKEMGETNYRHFASW" }
IIIVNEEEAAAASSSSFFFFRRRRDDDDGGGPE---SSSSLLLLYLRYITTVAAASFFFYEEEEPPPPGGGGNASNEEEEKKKKIAAVFYYLLILLTSRTSASSEEEETSTTGGEGVVVVVVIVYYYYASSASSSSHQQHRKKKDDGARRRRTVVT
{ "seq0": "INASFRDGESLYIAFEPGNEKIFLTSETGVVYASHRDRT", "seq1": "IEASFRDGSLLTAFEPGAEKAYISAESGVVYSSQKDRV", "seq2": "IEASFRDGSLRTAFEPGSEKAYLRSETEVIYSSQKGRV", "seq3": "VEASFRDPSLYVSYEPGNEKVLLTSETGVVYASHKART" }
LLLIVVVLAAAAIAASTTTTRRRRGGGGSASSGGGSERRRFFFFTTMTYYFHGGDGFFFFPPPPAAAAILFILLLLRRRRSSGACCRCTEETKKMKWWWWKGGWQQKQKRRRVVVVASAPSSSSSSVSNAANQQQQLIILYYFYHEEHHHHHRRKRMLLMIIVVEEEE
{ "seq0": "LVAITRGSGEFTYGFPAILRSCTKWKQKVASSNQLYHHRMIE", "seq1": "LVAATRGAGRFTYGFPALLRSCEKWGQRVSSSAQIYEHRLIE", "seq2": "LVAATRGSGRFMFDFPAFLRGREMWGKRVASVAQIFEHKLVE", "seq3": "ILASTRGSSRFTHGFPAILRACTKWWQRVPSSNQLYHHRMVE" }
NNNNNNNNSSTSDEEEGGGGYYYYLVLLMMMMLLLLQQQQQQQQEEESEEEENNNRYRYHLFFFKKSKFFFFCTCVHYHNSCCCRVRVHSSSTSTLLLLLLLQLAAAALVLLIIIIYYFYKRKRLRLRFFFFSASSLLSLTVTTVVIIDTTTTTTTPPLPTTTTLLLL
{ "seq0": "NNSDGYLMLQQEENYLKFCHSRHTLLALIYKLFSLTVDTPTL", "seq1": "NNSEGYVMLQQEENRFKFTYCVSSLLAVIYRRFALVVTTPTL", "seq2": "NNTEGYLMLQQEENYFSFCHCRSTLQALIFKLFSSTITTLTL", "seq3": "NNSEGYLMLQQSERHFKFVNCVSLLLALIYRRFSLTITTPTL" }
KKKKKKKPSTSSLLLLRRRRAVVVKNNSIMIISAAAMIIVAAA-EEKKSSSSEEEEEVAESPSSDEQEKDKKWWWWEEEEGSGGRRRRDDDEIIIIEEEENNQSQRPPKKKKITTTRRRRLLLLLLLLTTTTPPPPQNQQAVAAFNFFQQQQEQEDRKRRTTTTNTNN
{ "seq0": "KKSLRAKISMAESEESDKWEGRDIENQKIRLLTPQAFQERTN", "seq1": "KKTLRVNMAIAESEVPEDWESRDIENRKTRLLTPNVNQQKTT", "seq2": "KKSLRVNIAIAKSEASQKWEGRDIEQPKTRLLTPQAFQERTN", "seq3": "KPSLRVSIAVKSEESEKWEGREIESPKTRLLTPQAFQDRTN" }
GGGGYYYYLLLLSSSSLLLLRRRRYYYYKKKKIIVIKKKPEKKKRKRKVVVVAAAASTTSEPEEIVIVSSSSGEEEAAPAPDEEQQQHAAAPIVVVVVVVAAAAF-FFLLLLKKKKVVVVPQPPPPPI
{ "seq0": "GYLSLRYKIKERVASEISGAPQAIVAFLKVPP", "seq1": "GYLSLRYKIKKKVATPVSEADQAVVALKVQP", "seq2": "GYLSLRYKVKKRVATEISEPEQAVVAFLKVPP", "seq3": "GYLSLRYKIPKKVASEVSEAEHPVVAFLKVPI" }
MIIIRRRRIIIIRRRRKKTPGGGDFFIIVVVVLLLVAEEEIITIRRQKAVAAGGSGVVVVGGGGVMLLTTDTYFFFFFFFQQRQSSSSASSSDDDD-PLPCCCCEEGEEEEENNSNRRRRLLLIVVVISSNN
{ "seq0": "MRIRKGFVLAIRAGVGVTYFQSADCEENRLVS", "seq1": "IRIRKGFVLEIRVGVGMTFFQSSDPCEENRLVS", "seq2": "IRIRTGIVLETQASVGLDFFRSSDLCGESRLVN", "seq3": "IRIRPDIVVEIKAGVGLTFFQSSDPCEENRIIN" }
DDEDHHHHQQQHIAIAIVVVGGGGFYYYIVIVRRRRLLLLRNRNFFFFLLLLLLLLVIVIRAAADDDDRRRRIVVVETETARAREEEEYLCYVKVSDDDDLLLL-K-KTMMMRNQQKKKEREPEQHQHGGGGTTTTRRRRLLLL
{ "seq0": "DHQIIGFIRLRFLLVRDRIEAEYVDLTRKRQGTRL", "seq1": "DHQAVGYVRLNFLLIADRVTRELKDLKMNKEHGTRL", "seq2": "EHQIVGYIRLRFLLVADRVEAECVDLMQKPQGTRL", "seq3": "DHHAVGYVRLNFLLIADRVTREYSDLKMQEEHGTRL" }
VIVVGNGGPPPPEEEQGGGGDDNDLLLLTTKTGSGSAAAATTTALIIL--R---E---L---F---A---R---A---Q---L---A---D---Q---S---S---L---T---V---T---G---G-RR-RGG-GSA-S
{ "seq0": "VGPEGDLTGATLRGS", "seq1": "INPEGDLTSATIRGA", "seq2": "VGPEGNLKGATIRELFARAQLADQSSLTVTGG", "seq3": "VGPQGDLTSAALRGS" }
GGAGFF-FQQ-QVV-AYY-YLL-LGG-GAA-ADD-DYS-SIT-TVV-VVV-LII-IQE-ETT-TTT-TKK-KLL-LHH-HLL-LITTTAAAALLLLGGGGDDEEILVVGGGGKKKKYLLIVLLLKKKKDDDDSTSSFFFF
{ "seq0": "GFQVYLGADYIVVIQTTKLHLIALGDIGKYVKDSF", "seq1": "GFQVYLGADSTVVIETTKLHLTALGDLGKLLKDTF", "seq2": "ATALGEVGKLLKDSF", "seq3": "GFQAYLGADSTVLIETTKLHLTALGEVGKILKDSF" }
WWWWFFFFVLVVGGGG-T-TDDDDFFFFEEEQILIIRRRRNSNSAAAEGGGGEDEDYYYY-S---L---D---R---A---A---G---T---P---K---L---L---W---Y---D---G---W---Y---T---S---I---E---A---A---S---L---R---K---E---Y---P---E---I---T---K---P--KAKHVVVVDDDDWR-WKKKKENEEIMFMLLILREDEGGAGATAAQQQEPPPPSS-SDE-DKK-KGG-GAS-ADD-YDN-DLL-L
{ "seq0": "WFVGDFEIRNAGEYKVDWKEILRGAQPSDKGADDL", "seq1": "WFLGTDFELRSAGDYSLDRAAGTPKLLWYDGWYTSIEAASLRKEYPEITKPAVDRKNMLEGTQPSEKGSDNL", "seq2": "WFVGDFEIRNAGEYKVDKEFIDAAQP", "seq3": "WFVGTDFQIRSEGDYHVDWKEMLEGAEPSDKGAYDL" }
NNNEAAAATTTTMILLRRRRVIIINNNNIIIIIFFFFFFFFNHFSSSSKEKKAVVDYFFYEKKERRRRDDDDRSSRLLLLEKKKRRRR-HH--GG--DD--ND--MY--VV--TT--LL--NN--TT--AA--GG--EE-
{ "seq0": "NATMRVNIIFFSKAYERDRLER", "seq1": "NATIRINIFFNSEVFKRDSLKRHGDNMVTLNTAGE", "seq2": "NATLRINIFFHSKVFKRDSLKRHGDDYVTLNTAGE", "seq3": "EATLRINIFFFSKDYERDRLKR" }
GGGGSASSAAAMNNDNEDEREQQEAAAAAAAAAAAAFYFFDDDDKKKKSRRRQQQQGGGGEEEEIIMISSSKQQKQTTTTTTTTLLFLGGGKTTTTFFFFPPPPAAAAKKKKYYYYPPPPPPPPFFFFTTTSGGGGVVVVDDDDGGAGYYYYYFYYNNNNRKRKNGNN
{ "seq0": "GSANEEAAAFDKSQGEISQTTLGTFPAKYPPFTGVDGYYNRN", "seq1": "GAANDQAAAYDKRQGEISQTTLGTFPAKYPPFTGVDGYFNKG", "seq2": "GSADEQAAAFDKRQGEMSKTTFGTFPAKYPPFTGVDAYYNRN", "seq3": "GSMNREAAAFDKRQGEIKQTTLKTFPAKYPPFSGVDGYYNKN" }
VVVVILIIEEEEDNNNLVVVKKKKYHYHLLLLTTTVIMMLLLLFR-KRS-VTN-NGL-LLG-GGL-LIA-ASN-NNEEED-L---S--AAAAWWWWAASAGGGGLLLLIVIAQQEQIITIKSKKNNNNLLLLNNNK-Y---L---P---C---G--IIVILLLLTKKQSSSSSGGGPPPPLLLLKEEESSSSLLLL
{ "seq0": "VIEDLKYLTILRSNLGLANEAWAGLIQIKNLNILTSSPLKSL", "seq1": "VLENVKHLTMLELSAWAGLVQISNLNYLPCGILKSGPLESL", "seq2": "VIENVKYLTMLKVNLGLANEAWSGLIETKNLNVLKSGPLESL", "seq3": "VIENVKHLVLFRTGLGISNDAWAGLAQIKNLKILQSGPLESL" }
QRHQEEQEMMMMPPPPIIIITFFYAAAAVVVVPPPPEKEEAAAAFIFFQQQQIIIIAAAAESSEDDDDGGSGPPPPAAAASSSSHHHHAHRAVVIVVVVVEEEELLLLVVMVHHQHPPPPAAAATTTTHHHHDDDDTTPTPPPPIIIIYMKYNSASTTFT
{ "seq0": "QEMPITAVPEAFQIAEDGPASHAVVELVHPATHDTPIYNT", "seq1": "REMPIFAVPKAIQIASDGPASHHVVELVHPATHDTPIMST", "seq2": "HQMPIFAVPEAFQIASDSPASHRIVELMQPATHDPPIKAF", "seq3": "QEMPIYAVPEAFQIAEDGPASHAVVELVHPATHDTPIYST" }
PPPPSSSSQNQNKKKK-V-TVVVVDNDNEEEESSSSITITGGGGIIIIFFFFGGGRGNNNLLLLLLMHMLLLAAMATKTTDEDERKRK--S---L---D---K---I---I---V---E---Y---K---Y---R---E---A---T-DDDDPPPPLLILVACAWWWWEENEEEEELLLLTTTTDDDDVVVVDEEELLLLEN-ERR-RRRRREEEDQQQQGGGG-R--HHHH
{ "seq0": "PSQKVDESIGIFGGLLMATDRDPLVWEELTDVDLERREQGH", "seq1": "PSNKVVNESTGIFGNLLLAKEKDPLAWEELTDVELNRREQGRH", "seq2": "PSQKVDESIGIFGNLMLMTDRSLDKIIVEYKYREATDPICWNELTDVELREQGH", "seq3": "PSNKTVNESTGIFRNLHLATEKDPLAWEELTDVELERRDQGH" }
LLLLYYYYVVVVAAEAGGGGNNNNLLLLENNNLLLLRRRRQDDTGNNNPPPPQKQQAGGAMMMMDHHHASTTEKEETTTTEEEEHSSSLVILRRRRDDDDVIVVGGGGVLVVKRRKENHEWWWWIIIINTNESSSS
{ "seq0": "LYVAGNLELRQGPQAMDAETEHLRDVGVKEWINS", "seq1": "LYVAGNLNLRDNPKGMHSKTESVRDIGLRNWITS", "seq2": "LYVEGNLNLRDNPQGMHTETESIRDVGVRHWINS", "seq3": "LYVAGNLNLRTNPQAMHTETESLRDVGVKEWIES" }
ILILFFFFKKKK-LLL-IIILLLLQSQQFYFYVLVLKKKKKNNNQQQQQEQQGGGGMQQQQEEEPPPPNDNHRRRRIIIIYYYYEEEEKNKNRKRRGGGGAATALLLLKRRRRRRRDNNNGGGGKEEESGSGTTTTKKKKLLLLQQQQGLGGSVAAILIVEEEEAPSP
{ "seq0": "IFKLQFVKKQQGMQPNRIYEKRGALKRDGKSTKLQGSIEA", "seq1": "LFKLILSYLKNQEGQEPDRIYENKGALRRNGEGTKLQLVLEP", "seq2": "IFKLILQFVKNQQGQEPNRIYEKRGTLRRNGESTKLQGAIES", "seq3": "LFKLILQYLKNQQGQEPHRIYENRGALRRNGEGTKLQGAVEP" }
NHHHAAAAQKKKNNNNRVVVEEEEPPPPSWWWQQQQNNKNIIIINSSSTTTTVVHVTTTTEEEEEQQQEEEESSTGGGGGK-D-EEEEAAVAEEEQMIIIV---A---V---L---L---L---F---R---TTST--V---A-QQQKIIIIPAPAGGGG--I-RRRRHHHHEEEEGGGGEEEEFFLFTTTT
{ "seq0": "NAQNREPSQNINTVTEEESGKEAEMVAVLLLFRTQIPGRHEGEFT", "seq1": "HAKNVEPWQNISTVTEQESGEAEITQIAGRHEGEFT", "seq2": "HAKNVEPWQKISTHTEQETGDEVEISVAQIPGIRHEGELT", "seq3": "HAKNVEPWQNISTVTEQEGGEAQITKIAGRHEGEFT" }
KKKKTTTTVVVVGRAATTTTTKTTILLLLLLLHHWW-SNSTNKTRTRRGGGGDEDDYRFFLLLLILLLFFLLWWWWMLMMSS--WW--II--PP--TN--GG--SK--VL--RKRRTAAAPPPPKKKKLVVVLLLL--L-VVVVEPEEKQ--WW--CCAAKKKKLLVVAAAAEEEEREEEILLL
{ "seq0": "KTVGTTILHTRGDYLIFWMSWIPTGSVRTPKLLVEKWCKLAERI", "seq1": "KTVRTKLLHSNTGERLLFWLSWIPNGKLKAPKVLVPQWCKLAEEL", "seq2": "KTVATTLLWNKRGDFLLLWMRAPKVLLVEAKVAEEL", "seq3": "KTVATTLLWSTRGDFLLLWMRAPKVLVEAKVAEEL" }
VVVAEEQEEEDEMLLMSSSLYYYYLFVLLISLKMMKAAVANQENDHNDAAYAQNSKIVVVHQLGEEEQLLLLTMMTNK-NYF-YRR-RII-ILL-LYY-YRRRRRRRRNNNNDDDD--N-RRRRMLLLSTTVEEEEIIVV
{ "seq0": "VEEMSYLLKANDAQIHELTNYRILYRRNDRMSEI", "seq1": "VEELSYFIMAQHANVQELMKFRILYRRNDRLTEI", "seq2": "VQDLSYVSMVENYSVLELMRRNDNRLTEV", "seq3": "AEEMLYLLKANDAKVGQLTNYRILYRRNDRLVEV" }
SKSQIIVIKPKPVVVVAAAAEKEKEEEE-A---P---K---E---S---G--FFFFDGDGKRKKIIIIFFFFSS-SVM--A--AS--NDE-ESG-GQS-QIL-IQQ-QDE-DGG-GTT-TQE-EEE-EAF-AFVFFVAVVEQEEHHHHIIIITTTTNNDNGGGGEETEAVVVSTASDDDDIVIVAAAAGGDGRRRRIVVV
{ "seq0": "SIKVAEEFDKIFSVASDSQIQDGTQEAFVEHITNGEASDIAGRI", "seq1": "KIPVAKEAPKESGFGRIFSMEGSLQEGTEEFVAQHITNGEVTDVAGRV", "seq2": "SVKVAEEFDKIFFVEHITDGTVADIADRV", "seq3": "QIPVAKEFGKIFSANEGQIQDGTEEAFVEHITNGEVSDVAGRV" }
QQQQVVVVPPPPTTTTKKKKAAAANNHNLQGGTTTTNASSAAAALLLLMVVVAAAAYYYFQQQQRRKKAAAAPPPPIVPLATDDWWWWKKKKFFFLK---I---D---T---S---F---E---K---NNNNQQQQYWWWNSASKQRQSRNNQEEEIILLPPPPFYYYPPPPYYYYAGAG
{ "seq0": "QVPTKANLTNALMAYQRAPIAWKFKIDTSFEKNQYNKSQIPFPYA", "seq1": "QVPTKANQTAALVAYQRAPVTWKFNQWSQREIPYPYG", "seq2": "QVPTKAHGTSALVAYQKAPPDWKFNQWARNELPYPYA", "seq3": "QVPTKANGTSALVAFQKAPLDWKLNQWSQNELPYPYG" }
TTTTVIIVYVVYLLLLPPPPLLLLTAATVVVVLLLLANNAQRRNGGGGAPPGSGGSEEEESAASLIILFFFFAAAASPGAEEEERRRRPPPPIVVFNYYHMFFKDDDDQQRQYWWWYYYYLLLMEEEESSSSAGGGKKKKFIIIAEEQTSST
{ "seq0": "TVYLPLTVLAQGASESLFASERPINMDQYYLESAKFAT", "seq1": "TIVLPLAVLNRGPGEAIFAPERPVYFDQWYLESGKIES", "seq2": "TIVLPLAVLNRGPGEAIFAGERPVYFDRWYLESGKIES", "seq3": "TVYLPLTVLANGGSESLFAAERPFHKDQWYMESGKIQT" }
LLLLSSSTSAAADDDDFYFFGITGHDHHTTTTCFFCVMFV-I---H---A---P---F---K---H---S---N---A---L---H---K---R---T---D---R---I---E---L---L---T---A---E---D---L---V---N---L---I---T---A---G---L---D---G--YYYYLLLLQQQQTVVTA-LII-IID-NDLLLL--Q---I---E---M---F---T---K---K---R---Y---A---L-VVVVRRRRQRRQEESEPPPPVVIARRRRYAYYSSSS--R---K---K---Q---Y---Y---P---M---A-SGGKQQMQRRRRLLLLKSDK-GGGGGGD
{ "seq0": "LSSDFGHTCVYLQTAIDLVRQEPVRYSSQRLKG", "seq1": "LSADYIDTFMIHAPFKHSNALHKRTDRIELLTAEDLVNLITAGLDGYLQVLVRREPVRASGQRLSGG", "seq2": "LSADFTHTFFYLQVLINLQIEMFTKKRYALVRRSPIRYSRKKQYYPMAGMRLDGG", "seq3": "LTADFGHTCVYLQTIIDLVRQEPARYSKQRLKGD" }
ATTTSSTSGGGGPPPPGKKKVVVVVVVVIMMLIVVVLSMMVVVVRRRREEAEEEDEPPPPEEEEKKTKFFFFHHHQPPPPGGGGATTTYYFYKKKDLAALWWWWDDDDKKKKLLLIFFFFSDSSEEEELLLLQQQQ
{ "seq0": "ASGPGVVIILVREEPEKFHPGAYKLWDKLFSELQ", "seq1": "TSGPKVVMVSVREEPEKFHPGTYKAWDKLFDELQ", "seq2": "TTGPKVVMVMVRADPETFHPGTFKAWDKLFSELQ", "seq3": "TSGPKVVLVMVREEPEKFQPGTYDLWDKIFSELQ" }
DDDDTSSTRRRKREESYYFYKEEKDEEDEEEERKKRVVVVAKKADDDDSSSSLILLTTTTIIIIDDDESDSSEVVERRRREEEERRKRLFFLAHHPPPPPSTSSPPPPHHHHGGGGMNNNIVVIVVVVASSSMLMM
{ "seq0": "DTRRYKDERVADSLTIDSERERLAPSPHGMIVAM", "seq1": "DSREYEEEKVKDSITIDDVRERFHPTPHGNVVSL", "seq2": "DSREFEEEKVKDSLTIDSVREKFHPSPHGNVVSM", "seq3": "DTKSYKDERVADSLTIESERERLPPSPHGNIVSM" }
HYYYFFFFSPSPQQQQMMRMLLYLRRYRKKKKGGGGKKKKPPPPRRRKNNINIIIIASSSYYYYQQQQEEDERRRRDDDDVVAIDDDGTTTTLMLMILLILLMLNNYNMQMQMMMMLLLIKKKKGGG-DDD-EEE-ETE-
{ "seq0": "HFSQMLRKGKPRNIAYQERDVDTLILNMMLKGDEE", "seq1": "YFPQMLRKGKPRNISYQERDVDTMLLNQMLKGDET", "seq2": "YFSQRYYKGKPRIISYQDRDADTLLMYMMLKGDEE", "seq3": "YFPQMLRKGKPKNISYQERDIGTMILNQMIK" }
KNNNAASCEKEDSQSSFFFFSNSQVIVVDDDDQQQQEEEAPPPPVVAVHRHHIIILLLLARRRRQQQQGAGGIIIVMMMMWWWWEDEELILLYFYYNRRRLFLLEEESEEEENNNNATTKAAAANNQNLLLLGGGGFYFFAAAAQQQK
{ "seq0": "KAESFSVDQEPVHILRQGIMWELYNLEENAANLGFAQ", "seq1": "NAKQFNIDQEPVRILRQAIMWDIFRFEENTANLGYAQ", "seq2": "NSESFSVDQEPAHILRQGIMWELYRLEENTAQLGFAQ", "seq3": "NCDSFQVDQAPVHLARQGVMWELYRLSENKANLGFAK" }
KKKKFLLLEPEEDDDDRRRREEEEAMMMRRRQDAEAAAAAVAAARRRRHYYYNKNSLLLLCCCCLWWWFFFFYFYYA-A-D-D---R---K---R-L-L-V-V-V-V-A-S-L-I-K-K-E-E-KTTTWWFWGSSSTSTSQIKIAVIVKGGGDEDETTTTIMIVAAAAEEEENNDNLLLLQEEE
{ "seq0": "KFEDREARDAVRHNLCLFYADLVVALKEKWGTQAKDTIAENLQ", "seq1": "KLPDREMRAAARYKLCWFFTWSSIVGETMAENLE", "seq2": "KLEDREMREAARYNLCWFYADRKRLVVSIKETFSTKIGDTIAEDLE", "seq3": "KLEDREMQAAARYSLCWFYTWSSIVGETVAENLE" }
YYYYIIIILLLLLGLAPPPPKKKKYYYYNNNNWWWWKKKKLLLLKNKNDEDEQQQQLLLLLLLLD---L---L---TPTSAAAAEEEEQQQKKKKRGGGGYYYYETDSPPPPQQQQEEEEHHHHDDDDLLLIYYYYHHYR--R---F-KKKKKTTTLVLVEEAQPPPPCTCT
{ "seq0": "YILLPKYNWKLKDQLLDLLTAEQKGYEPQEHDLYHKKLEPC", "seq1": "YILGPKYNWKLNEQLLPAEQKGYTPQEHDLYHKTVEPT", "seq2": "YILLPKYNWKLKDQLLTAEQKGYDPQEHDLYYRFKTLAPC", "seq3": "YILAPKYNWKLNEQLLSAEKRGYSPQEHDIYRKTVQPT" }

Multiple Sequence Alignment as a Sequence-to-Sequence Learning Problem

Abstract:

The sequence alignment problem is one of the most fundamental problems in bioinformatics and a plethora of methods were devised to tackle it. Here we introduce BetaAlign, a methodology for aligning sequences using an NLP approach. BetaAlign accounts for the possible variability of the evolutionary process among different datasets by using an ensemble of transformers, each trained on millions of samples generated from a different evolutionary model. Our approach leads to alignment accuracy that is similar and often better than commonly used methods, such as MAFFT, DIALIGN, ClustalW, T-Coffee, PRANK, and MUSCLE. image

An illustration of aligning sequences with sequence-to-sequence learning. (a) Consider two input sequences "AAG" and "ACGG". (b) The result of encoding the unaligned sequences into the source language (Concat representation). (c) The sentence from the source language is translated to the target language via a transformer model. (d) The translated sentence in the target language (Spaces representation). (e) The resulting alignment, decoded from the translated sentence, in which "AA-G" is aligned to "ACGG". The transformer architecture illustration is adapted from (Vaswani et al., 2017).

Data:

We used SpartaABC (Loewenthal et al., 2021) to generate millions of true alignments. SpartaABC requires the following input: (1) a rooted phylogenetic tree, which includes a topology and branch lengths; (2) a substitution model (amino acids or nucleotides); (3) root sequence length; (4) the indel model parameters, which include: insertion rate (R_I), deletion rate (R_D), a parameter for the insertion Zipfian distribution (A_I), and a parameter for the deletion Zipfian distribution (A_D). MSAs were simulated along random phylogenetic tree topologies generated using the program ETE version 3.0 (Huerta-Cepas et al., 2016) with default parameters.

We generated 1,495,000, 2,000 and 3,000, protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range (0.5,1.0). Next, the sequences were generated using SpartaABC with the following parameters: R_I,R_D \in (0.0,0.05), A_I, A_D \in (1.01,2.0). The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range [32,44]. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides (0.37, 0.166, 0.307, 0.158), in the order "T", "C", "A" and "G"; (2) with the substitutions rate (0.444, 0.0843, 0.116, 0.107, 0.00027), in the order "a", "b", "c", "d", and "e" for the substitution matrix.

Example:

The following example correspond for the illustrated MSA in the figure above:

{"MSA": "AAAC-GGG", "unaligned_seqs": {"seq0": "AAG", "seq1": "ACGG"}}

APA

Dotan, E., Belinkov, Y., Avram, O., Wygoda, E., Ecker, N., Alburquerque, M., Keren, O., Loewenthal, G., & Pupko T. (2023). Multiple sequence alignment as a sequence-to-sequence learning problem. The Eleventh International Conference on Learning Representations (ICLR 2023).

BibTeX

@article{Dotan_multiple_2023,
  author = {Dotan, Edo and Belinkov, Yonatan and Avram, Oren and Wygoda, Elya and Ecker, Noa and Alburquerque, Michael and Keren, Omri and Loewenthal, Gil and Pupko, Tal},
  month = aug,
  title = {{Multiple sequence alignment as a sequence-to-sequence learning problem}},
  year = {2023}
}
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