tags
sequencelengths 2
166
| tokens
sequencelengths 2
166
|
---|---|
[
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Since",
"HUVECs",
"released",
"superoxide",
"anions",
"in",
"response",
"to",
"TNF",
",",
"and",
"H2O2",
"induces",
"VCAM-1",
",",
"PDTC",
"may",
"act",
"as",
"a",
"radical",
"scavenger",
"."
] |
[
0,
3,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Although",
"ICAM-1",
"induction",
"was",
"unaffected",
",",
"inhibitors",
"of",
"NADPH",
"oxidase",
"(",
"apocynin",
")",
"or",
"cytochrome",
"P-450",
"(",
"SKF525a",
")",
"suppressed",
"VCAM-1",
"induction",
"by",
"TNF",
",",
"revealing",
"that",
"several",
"radical-generating",
"systems",
"are",
"involved",
"in",
"its",
"regulation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"PDTC",
",",
"apocynin",
",",
"or",
"SKF525a",
"decreased",
"adhesion",
"of",
"monocytic",
"U937",
"cells",
"to",
"TNF-treated",
"HUVECs",
"(",
"by",
"75",
"%",
"at",
"100",
"mumol/L",
"PDTC",
")",
"."
] |
[
0,
0,
3,
4,
4,
3,
0,
0,
7,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"Inhibition",
"by",
"anti-VCAM-1",
"monoclonal",
"antibody",
"1G11",
"indicated",
"that",
"U937",
"adhesion",
"was",
"VCAM-1",
"dependent",
"and",
"suppression",
"by",
"antioxidants",
"was",
"due",
"to",
"reduced",
"VCAM-1",
"induction",
"."
] |
[
0,
0,
0,
0,
0,
0,
0
] | [
"(",
"ABSTRACT",
"TRUNCATED",
"AT",
"250",
"WORDS",
")"
] |
[
0,
0,
0,
3,
4,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] | [
"Displacement",
"of",
"an",
"E-box-binding",
"repressor",
"by",
"basic",
"helix-loop-helix",
"proteins",
":",
"implications",
"for",
"B-cell",
"specificity",
"of",
"the",
"immunoglobulin",
"heavy-chain",
"enhancer",
"."
] |
[
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
0
] | [
"The",
"activity",
"of",
"the",
"immunoglobulin",
"heavy-chain",
"(",
"IgH",
")",
"enhancer",
"is",
"restricted",
"to",
"B",
"cells",
",",
"although",
"it",
"binds",
"both",
"B-cell-restricted",
"and",
"ubiquitous",
"transcription",
"factors",
"."
] |
[
0,
0,
0,
1,
0,
5,
6,
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"Activation",
"of",
"the",
"enhancer",
"in",
"non-B",
"cells",
"upon",
"overexpression",
"of",
"the",
"basic",
"helix-loop-helix",
"(",
"bHLH",
")",
"protein",
"E2A",
"appears",
"to",
"be",
"mediated",
"not",
"only",
"by",
"the",
"binding",
"of",
"E2A",
"to",
"its",
"cognate",
"E",
"box",
"but",
"also",
"by",
"the",
"resulting",
"displacement",
"of",
"a",
"repressor",
"from",
"that",
"same",
"site",
"."
] |
[
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0
] | [
"We",
"have",
"identified",
"a",
"``",
"two-handed",
"''",
"zinc",
"finger",
"protein",
",",
"denoted",
"ZEB",
",",
"the",
"DNA-binding",
"specificity",
"of",
"which",
"mimics",
"that",
"of",
"the",
"cellular",
"repressor",
"."
] |
[
0,
0,
0,
0,
1,
2,
0,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
5,
6,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0
] | [
"By",
"employing",
"a",
"derivative",
"E",
"box",
"that",
"binds",
"ZEB",
"but",
"not",
"E2A",
",",
"we",
"have",
"shown",
"that",
"the",
"repressor",
"is",
"active",
"in",
"B",
"cells",
"and",
"the",
"IgH",
"enhancer",
"is",
"silenced",
"in",
"the",
"absence",
"of",
"binding",
"competition",
"by",
"bHLH",
"proteins",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0
] | [
"Hence",
",",
"we",
"propose",
"that",
"a",
"necessary",
"prerequisite",
"of",
"enhancer",
"activity",
"is",
"the",
"B-cell-specific",
"displacement",
"of",
"a",
"ZEB-like",
"repressor",
"by",
"bHLH",
"proteins",
"."
] |
[
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Inhibition",
"of",
"NF-kappa",
"B",
"by",
"sodium",
"salicylate",
"and",
"aspirin",
"[",
"see",
"comments",
"]"
] |
[
0,
3,
4,
3,
4,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0,
3,
0,
0,
3,
4,
0
] | [
"The",
"transcription",
"factor",
"nuclear",
"factor-kappa",
"B",
"(",
"NF-kappa",
"B",
")",
"is",
"critical",
"for",
"the",
"inducible",
"expression",
"of",
"multiple",
"cellular",
"and",
"viral",
"genes",
"involved",
"in",
"inflammation",
"and",
"infection",
"including",
"interleukin-1",
"(",
"IL-1",
")",
",",
"IL-6",
",",
"and",
"adhesion",
"molecules",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"anti-inflammatory",
"drugs",
"sodium",
"salicylate",
"and",
"aspirin",
"inhibited",
"the",
"activation",
"of",
"NF-kappa",
"B",
",",
"which",
"further",
"explains",
"the",
"mechanism",
"of",
"action",
"of",
"these",
"drugs",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
4,
4,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0
] | [
"This",
"inhibition",
"prevented",
"the",
"degradation",
"of",
"the",
"NF-kappa",
"B",
"inhibitor",
",",
"I",
"kappa",
"B",
",",
"and",
"therefore",
"NF-kappa",
"B",
"was",
"retained",
"in",
"the",
"cytosol",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
0,
0,
7,
8,
8,
0
] | [
"Sodium",
"salicylate",
"and",
"aspirin",
"also",
"inhibited",
"NF-kappa",
"B",
"-dependent",
"transcription",
"from",
"the",
"Ig",
"kappa",
"enhancer",
"and",
"the",
"human",
"immunodeficiency",
"virus",
"(",
"HIV",
")",
"long",
"terminal",
"repeat",
"(",
"LTR",
")",
"in",
"transfected",
"T",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] | [
"Effects",
"of",
"the",
"antisense",
"myb",
"expression",
"on",
"hemin-",
"and",
"erythropoietin-",
"induced",
"erythroid",
"differentiation",
"of",
"K562",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
3,
0,
3,
0,
0,
3,
0,
3,
0,
0,
0,
0,
1,
2,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0
] | [
"In",
"order",
"to",
"elucidate",
"the",
"role",
"of",
"c-myb",
"gene",
"in",
"erythroid",
"differentiation",
"of",
"K562",
"cell",
"induced",
"by",
"hemin",
"(",
"Hm",
")",
"and",
"erythropoietin",
"(",
"Epo",
")",
",",
"we",
"constructed",
"recombinant",
"plasmid",
"that",
"could",
"produce",
"antisense",
"myb",
"RNA",
"after",
"induction",
"with",
"dexamethasone",
"."
] |
[
0,
0,
0,
3,
0,
7,
8,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0
] | [
"During",
"treatment",
"with",
"Hm",
",",
"K562",
"cells",
"constitutively",
"expressed",
"c-myb",
"mRNA",
",",
"and",
"50",
"%",
"of",
"them",
"began",
"to",
"synthesize",
"hemoglobin",
"(",
"Hb",
")",
"."
] |
[
0,
0,
9,
10,
10,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] | [
"Expression",
"of",
"antisense",
"myb",
"RNA",
"reduced",
"the",
"amount",
"of",
"c-myb",
"mRNA",
",",
"and",
"the",
"percentage",
"of",
"Hb-synthesizing",
"cells",
"was",
"decreased",
"to",
"20",
"%",
"."
] |
[
0,
0,
0,
0,
3,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0,
3,
0,
0,
9,
10,
10,
0,
0
] | [
"In",
"the",
"presence",
"of",
"Epo",
",",
"c-myb",
"mRNA",
"declined",
"and",
"20",
"%",
"of",
"K562",
"cells",
"synthesized",
"Hb",
"regardless",
"of",
"antisense",
"myb",
"RNA",
"expression",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
10,
0,
0,
3,
0,
0,
0
] | [
"It",
"is",
"suggested",
"that",
"constitutive",
"expression",
"of",
"c-myb",
"mRNA",
"is",
"necessary",
"for",
"Hm",
"-induced",
"differentiation",
",",
"and",
"that",
"a",
"decrease",
"in",
"the",
"amount",
"of",
"c-myb",
"mRNA",
"induced",
"by",
"antisense",
"myb",
"RNA",
"expression",
"suppresses",
"Hm",
"-induced",
"differentiation",
"."
] |
[
0,
0,
0,
9,
10,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"The",
"amount",
"of",
"c-myb",
"mRNA",
"in",
"K562",
"cells",
"was",
"reduced",
"during",
"the",
"differentiation",
"induced",
"by",
"Epo",
"."
] |
[
0,
0,
9,
10,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"Expression",
"of",
"GATA-1",
"mRNA",
"was",
"almost",
"constant",
"during",
"Hm",
"-induced",
"differentiation",
",",
"but",
"increased",
"during",
"Epo",
"treatment",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
7,
8,
0
] | [
"It",
"is",
"supposed",
"that",
"the",
"mechanism",
"of",
"Hm",
"-induced",
"differentiation",
"is",
"distinguished",
"from",
"that",
"of",
"Epo",
"-induced",
"differentiation",
"in",
"K562",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Prenatal",
"immune",
"challenge",
"alters",
"the",
"hypothalamic-pituitary-adrenocortical",
"axis",
"in",
"adult",
"rats",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"investigated",
"whether",
"non-abortive",
"maternal",
"infections",
"would",
"compromise",
"fetal",
"brain",
"development",
"and",
"alter",
"hypothalamic-pituitary-adrenocortical",
"(",
"HPA",
")",
"axis",
"functioning",
"when",
"adult",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"To",
"study",
"putative",
"teratogenic",
"effects",
"of",
"a",
"T",
"cell-mediated",
"immune",
"response",
"versus",
"an",
"endotoxic",
"challenge",
",",
"10-d-pregnant",
"rats",
"received",
"a",
"single",
"intraperitoneal",
"injection",
"of",
"5",
"x",
"10",
"(",
"8",
")",
"human",
"red",
"blood",
"cells",
"(",
"HRBC",
")",
"or",
"gram-negative",
"bacterial",
"endotoxin",
"(",
"Escherichia",
"coli",
"LPS",
":",
"30",
"micrograms/kg",
")",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"adult",
"male",
"progeny",
"(",
"3",
"mo",
"old",
")",
"of",
"both",
"experimental",
"groups",
"showed",
"increased",
"basal",
"plasma",
"corticosterone",
"levels",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"addition",
",",
"after",
"novelty",
"stress",
"the",
"HRBC",
"group",
",",
"but",
"not",
"the",
"LPS",
"group",
",",
"showed",
"increased",
"ACTH",
"and",
"corticosterone",
"levels",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Both",
"groups",
"showed",
"substantial",
"decreases",
"in",
"mineralocorticoid",
"(",
"MR",
")",
"and",
"glucocorticoid",
"receptor",
"(",
"GR",
")",
"levels",
"in",
"the",
"hippocampus",
",",
"a",
"limbic",
"brain",
"structure",
"critical",
"for",
"HPA",
"axis",
"regulation",
",",
"whereas",
"GR",
"concentrations",
"in",
"the",
"hypothalamus",
"were",
"unchanged",
"and",
"in",
"anterior",
"pituitary",
"were",
"slightly",
"increased",
"."
] |
[
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0
] | [
"HRBC",
"and",
"LPS",
"indeed",
"stimulated",
"the",
"maternal",
"immune",
"system",
"as",
"revealed",
"by",
"specific",
"anti-HRBC",
"antibody",
"production",
"and",
"enhanced",
"IL-1",
"beta",
"mRNA",
"expression",
"in",
"splenocytes",
",",
"respectively",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"This",
"study",
"demonstrates",
"that",
"a",
"T",
"cell-mediated",
"immune",
"response",
"as",
"well",
"as",
"an",
"endotoxic",
"challenge",
"during",
"pregnancy",
"can",
"induce",
"anomalies",
"in",
"HPA",
"axis",
"function",
"in",
"adulthood",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Clinically",
",",
"it",
"may",
"be",
"postulated",
"that",
"disturbed",
"fetal",
"brain",
"development",
"due",
"to",
"prenatal",
"immune",
"challenge",
"increases",
"the",
"vulnerability",
"to",
"develop",
"mental",
"illness",
"involving",
"inadequate",
"responses",
"to",
"stress",
"."
] |
[
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0
] | [
"A",
"low",
"NM23.H1",
"gene",
"expression",
"identifying",
"high",
"malignancy",
"human",
"melanomas",
"."
] |
[
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"NM23",
"gene",
"has",
"been",
"proposed",
"as",
"a",
"metastasis-suppressor",
"gene",
",",
"and",
"its",
"use",
"has",
"been",
"suggested",
"as",
"prognostic",
"factor",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"NM23",
"was",
"identified",
"in",
"a",
"system",
"of",
"murine",
"melanoma",
"cell",
"lines",
",",
"in",
"which",
"an",
"inverse",
"relationship",
"was",
"found",
"between",
"NM23",
"expression",
"and",
"metastatic",
"ability",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"a",
"human",
"malignant",
"melanoma",
"study",
"NM23",
"expression",
"was",
"found",
"to",
"be",
"significantly",
"lower",
"in",
"metastases",
"that",
"developed",
"less",
"than",
"24",
"months",
"after",
"diagnosis",
"of",
"the",
"primary",
"tumours",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"present",
"paper",
"studies",
"the",
"expression",
"of",
"the",
"NM23.H1",
"gene",
"in",
"cell",
"lines",
"which",
"derive",
"from",
"primary",
"or",
"metastatic",
"human",
"malignant",
"melanomas",
"in",
"relation",
"to",
"staging",
",",
"infiltration",
"degree",
",",
"lymphocytic",
"infiltration",
",",
"cell",
"morphology",
",",
"cell",
"pigmentation",
",",
"karyotype",
",",
"and",
"disease-free",
"survival",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] | [
"The",
"level",
"of",
"mRNA",
"expression",
"of",
"the",
"NM23",
"gene",
"is",
"significantly",
"lower",
"in",
"cell",
"lines",
"that",
"derive",
"from",
"more",
"infiltrating",
"primary",
"melanomas",
"than",
"in",
"cell",
"lines",
"obtained",
"from",
"less",
"infiltrating",
"tumours",
"."
] |
[
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Moreover",
",",
"cell",
"lines",
"derived",
"from",
"tumours",
"of",
"patients",
"with",
"a",
"disease-free",
"survival",
"of",
"more",
"than",
"24",
"months",
"(",
"24-58",
"months",
")",
"express",
"the",
"NM23",
"gene",
"at",
"higher",
"levels",
"than",
"cell",
"lines",
"obtained",
"from",
"melanomas",
"of",
"patients",
"with",
"a",
"disease-free",
"survival",
"of",
"less",
"than",
"24",
"months",
"(",
"6-15",
"months",
")",
"."
] |
[
0,
0,
0,
0,
3,
4,
0,
0,
3,
0,
0,
0,
5,
6,
6,
6,
0,
0,
0,
3,
4,
0
] | [
"Activation",
"of",
"a",
"novel",
"serine/threonine",
"kinase",
"that",
"phosphorylates",
"c-Fos",
"upon",
"stimulation",
"of",
"T",
"and",
"B",
"lymphocytes",
"via",
"antigen",
"and",
"cytokine",
"receptors",
"."
] |
[
0,
0,
3,
4,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Ligation",
"of",
"Ag",
"receptors",
"in",
"T",
"and",
"B",
"lymphocytes",
"initiates",
"signal",
"transduction",
"cascades",
"which",
"alter",
"the",
"expression",
"of",
"genes",
"that",
"regulate",
"cellular",
"proliferation",
"and",
"differentiation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
0
] | [
"The",
"transmission",
"of",
"signals",
"from",
"the",
"membrane",
"to",
"the",
"nucleus",
"is",
"mediated",
"principally",
"through",
"the",
"action",
"of",
"protein",
"tyrosine",
"and",
"serine/threonine",
"kinases",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
3,
4,
0
] | [
"We",
"have",
"identified",
"and",
"characterized",
"a",
"novel",
"serine/threonine",
"kinase",
"that",
"phosphorylated",
"the",
"proto-oncogene",
"product",
",",
"c-Fos",
",",
"and",
"is",
"termed",
"Fos",
"kinase",
"."
] |
[
3,
4,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
0,
7,
0,
5,
6,
6,
6,
0,
0,
0,
0,
3,
0,
3,
0,
0,
7,
8,
8,
8,
7,
0,
7,
0,
0,
0
] | [
"Fos",
"kinase",
"was",
"rapidly",
"activated",
"after",
"ligation",
"of",
"the",
"CD3",
"and",
"CD2",
"receptors",
"in",
"Jurkat",
"and",
"normal",
"human",
"T",
"lymphocytes",
"and",
"in",
"response",
"to",
"IL-6",
"and",
"anti-IgM",
"in",
"the",
"human",
"B",
"cell",
"lines",
"AF10",
"and",
"Ramos",
",",
"respectively",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"The",
"phorbol",
"ester",
",",
"PMA",
",",
"was",
"also",
"a",
"potent",
"inducer",
"of",
"Fos",
"kinase",
"activity",
"in",
"all",
"of",
"the",
"above",
"populations",
",",
"suggesting",
"that",
"PKC",
"plays",
"a",
"role",
"in",
"the",
"regulation",
"of",
"this",
"enzyme",
"."
] |
[
3,
4,
0,
3,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"Fos",
"kinase",
"phosphorylates",
"c-Fos",
"at",
"a",
"site",
"near",
"the",
"C-terminus",
",",
"as",
"well",
"as",
"a",
"peptide",
"derived",
"from",
"this",
"region",
"(",
"residues",
"359-370",
",",
"RKGSSSNEPSSD",
")",
",",
"and",
"Fos",
"peptide",
"competitively",
"inhibited",
"c-Fos",
"phosphorylation",
"."
] |
[
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
3,
4,
4,
0,
3,
4,
4,
0,
3,
4,
4,
0,
3,
4,
0,
3,
0,
3,
0
] | [
"Fos",
"kinase",
"was",
"shown",
"to",
"be",
"distinct",
"from",
"other",
"identified",
"serine/threonine",
"kinases",
",",
"including",
"protein",
"kinase",
"A",
",",
"protein",
"kinase",
"C",
",",
"casein",
"kinase",
"II",
",",
"MAP",
"kinases",
",",
"p70S6K",
"and",
"p90RSK",
"."
] |
[
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Fos",
"kinase",
"was",
"purified",
"by",
"anion",
"exchange",
"chromatography",
"and",
"exhibited",
"an",
"apparent",
"M",
"(",
"r",
")",
"=",
"65",
",",
"000",
"and",
"isoelectric",
"point",
"=",
"6.1",
"."
] |
[
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Fos",
"kinase",
"may",
"play",
"a",
"role",
"in",
"transcriptional",
"regulation",
"through",
"its",
"capacity",
"to",
"phosphorylate",
"c-Fos",
"at",
"a",
"site",
"required",
"for",
"expression",
"of",
"the",
"transcriptional",
"transrepressive",
"activity",
"of",
"this",
"molecule",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0
] | [
"Moreover",
",",
"its",
"rapid",
"activation",
"suggests",
"it",
"may",
"have",
"a",
"wider",
"role",
"within",
"signal",
"transduction",
"cascades",
"in",
"lymphocytes",
"."
] |
[
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Antigenic",
"specificities",
"of",
"human",
"CD4+",
"T-cell",
"clones",
"recovered",
"from",
"recurrent",
"genital",
"herpes",
"simplex",
"virus",
"type",
"2",
"lesions",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"Lesions",
"resulting",
"from",
"recurrent",
"genital",
"herpes",
"simplex",
"virus",
"(",
"HSV",
")",
"infection",
"are",
"characterized",
"by",
"infiltration",
"of",
"CD4+",
"lymphocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"have",
"investigated",
"the",
"antigenic",
"specificity",
"of",
"47",
"HSV-specific",
"CD4+",
"T-cell",
"clones",
"recovered",
"from",
"the",
"HSV-2",
"buttock",
"and",
"thigh",
"lesions",
"of",
"five",
"patients",
"."
] |
[
0,
0,
0,
0,
0,
3,
4,
4,
4,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0
] | [
"Clones",
"with",
"proliferative",
"responses",
"to",
"recombinant",
"truncated",
"glycoprotein",
"B",
"(",
"gB",
")",
"or",
"gD",
"of",
"HSV-2",
"or",
"purified",
"natural",
"gC",
"of",
"HSV-2",
"comprised",
"a",
"minority",
"of",
"the",
"total",
"number",
"of",
"HSV-specific",
"clones",
"isolated",
"from",
"lesions",
"."
] |
[
0,
7,
8,
8,
8,
8,
0,
0,
0,
0
] | [
"The",
"gC2-",
"and",
"gD2-specific",
"CD4+",
"clones",
"had",
"cytotoxic",
"activity",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"approximate",
"locations",
"of",
"the",
"HSV-2",
"genes",
"encoding",
"HSV-2",
"type-specific",
"CD4+",
"antigens",
"have",
"been",
"determined",
"by",
"using",
"HSV-1",
"x",
"HSV-2",
"intertypic",
"recombinant",
"virus",
"and",
"include",
"the",
"approximate",
"map",
"regions",
"0.30",
"to",
"0.46",
",",
"0.59",
"to",
"0.67",
",",
"0.67",
"to",
"0.73",
",",
"and",
"0.82",
"to",
"1.0",
"units",
"."
] |
[
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
8,
8,
0,
0,
0,
3,
4,
4,
4,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
0,
0,
0,
0,
0
] | [
"The",
"antigenic",
"specificity",
"of",
"an",
"HLA",
"DQ2-restricted",
",",
"HSV-2",
"type-specific",
"T-cell",
"clone",
"was",
"mapped",
"to",
"amino",
"acids",
"425",
"to",
"444",
"of",
"VP16",
"of",
"HSV-2",
"by",
"sequential",
"use",
"of",
"an",
"intertypic",
"recombinant",
"virus",
"containing",
"VP16",
"of",
"HSV-2",
"in",
"an",
"HSV-1",
"background",
",",
"recombinant",
"VP16",
"fusion",
"proteins",
",",
"and",
"synthetic",
"peptides",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Each",
"of",
"the",
"remaining",
"four",
"patients",
"also",
"yielded",
"at",
"least",
"one",
"type-specific",
"T-cell",
"clone",
"reactive",
"with",
"an",
"HSV-2",
"epitope",
"mapping",
"to",
"approximately",
"0.67",
"to",
"0.73",
"map",
"units",
"."
] |
[
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"antigenic",
"specificities",
"of",
"lesion-derived",
"CD4+",
"T-cell",
"clones",
"are",
"quite",
"diverse",
"and",
"include",
"at",
"least",
"10",
"epitopes",
"."
] |
[
7,
8,
8,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Human",
"T-cell",
"clones",
"reactive",
"with",
"gC",
"and",
"VP16",
"are",
"reported",
"here",
"for",
"the",
"first",
"time",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0
] | [
"Marked",
"basophilia",
"in",
"acute",
"promyelocytic",
"leukaemia",
"treated",
"with",
"all-trans",
"retinoic",
"acid",
":",
"molecular",
"analysis",
"of",
"the",
"cell",
"origin",
"of",
"the",
"basophils",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"report",
"a",
"patient",
"with",
"acute",
"promyelocytic",
"leukaemia",
"who",
"developed",
"marked",
"basophilia",
"during",
"all-trans",
"retinoic",
"acid",
"treatment",
"."
] |
[
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0
] | [
"We",
"studied",
"genomic",
"DNA",
"and",
"RNA",
"extracted",
"from",
"the",
"patient",
"'s",
"peripheral",
"leucocytes",
"in",
"order",
"to",
"determine",
"the",
"origin",
"of",
"the",
"basophils",
"."
] |
[
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"RAR",
"alpha",
"rearranged",
"band",
"in",
"the",
"Southern",
"blot",
"analysis",
"and",
"a",
"chimaeric",
"product",
"of",
"PML-RAR",
"alpha",
"by",
"polymerase",
"chain",
"reaction",
"were",
"strongly",
"visible",
"before",
"ATRA",
"treatment",
",",
"but",
"at",
"the",
"time",
"of",
"maximal",
"basophilia",
"both",
"of",
"them",
"were",
"markedly",
"diminished",
"."
] |
[
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] | [
"These",
"findings",
"suggest",
"that",
"the",
"basophils",
"which",
"appeared",
"during",
"the",
"ATRA",
"treatment",
"are",
"reactive",
"in",
"nature",
"rather",
"than",
"a",
"leukaemic",
"clone",
"."
] |
[
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Activation",
"of",
"the",
"interleukin",
"6",
"gene",
"by",
"Mycobacterium",
"tuberculosis",
"or",
"lipopolysaccharide",
"is",
"mediated",
"by",
"nuclear",
"factors",
"NF-IL6",
"and",
"NF-kappa",
"B",
"[",
"published",
"erratum",
"appears",
"in",
"Proc",
"Natl",
"Acad",
"Sci",
"U",
"S",
"A",
"1995",
"Apr",
"11",
";",
"92",
"(",
"8",
")",
":",
"3632",
"]"
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"host",
"response",
"to",
"Mycobacterium",
"tuberculosis",
"includes",
"granuloma",
"formation",
"at",
"sites",
"of",
"infection",
"and",
"systemic",
"symptoms",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0
] | [
"Cytokines",
"have",
"been",
"identified",
"by",
"immunohistochemistry",
"in",
"granulomas",
"in",
"animal",
"models",
"of",
"bacillus",
"Calmette-Guerin",
"(",
"BCG",
")",
"infection",
"and",
"are",
"released",
"by",
"mononuclear",
"phagocytes",
"upon",
"stimulation",
"by",
"mycobacterial",
"proteins",
"."
] |
[
0,
0,
0,
0,
0,
3,
3,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"this",
"regard",
",",
"the",
"cytokine",
"interleukin",
"6",
"(",
"IL-6",
")",
"may",
"play",
"a",
"role",
"in",
"the",
"clinical",
"manifestations",
"and",
"pathological",
"events",
"of",
"tuberculosis",
"infection",
"."
] |
[
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"We",
"have",
"demonstrated",
"that",
"lipoarabinomannan",
"(",
"LAM",
")",
"from",
"the",
"mycobacterial",
"cell",
"wall",
",",
"which",
"was",
"virtually",
"devoid",
"of",
"lipopolysaccharide",
"(",
"LPS",
")",
",",
"stimulated",
"mononuclear",
"phagocytes",
"to",
"release",
"IL-6",
"in",
"a",
"dose-response",
"manner",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
5,
6,
6,
0
] | [
"LAM",
"and",
"LPS",
"were",
"potent",
"inducers",
"of",
"IL-6",
"gene",
"expression",
"in",
"peripheral",
"blood",
"monocytes",
"."
] |
[
0,
3,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
3,
4,
0,
0
] | [
"Both",
"LAM",
"-and",
"LPS-inducible",
"IL-6",
"promoter",
"activity",
"was",
"localized",
"to",
"a",
"DNA",
"fragment",
",",
"positions",
"-158",
"to",
"-49",
",",
"by",
"deletion",
"analysis",
"and",
"chloramphenicol",
"acetyltransferase",
"assay",
"."
] |
[
0,
3,
4,
4,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0
] | [
"Two",
"nuclear",
"factor",
"NF-IL6",
"(",
"positions",
"-153",
"to",
"-145",
"and",
"-83",
"to",
"-75",
")",
"and",
"one",
"nuclear",
"factor",
"NF-kappa",
"B",
"(",
"positions",
"-72",
"to",
"-63",
")",
"motifs",
"are",
"present",
"within",
"this",
"fragment",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Site-directed",
"mutagenesis",
"of",
"one",
"or",
"more",
"of",
"these",
"motifs",
"within",
"the",
"IL-6",
"promoter",
"demonstrated",
"that",
"each",
"has",
"positive",
"regulatory",
"activity",
"and",
"that",
"they",
"could",
"act",
"in",
"a",
"function-",
"and",
"orientation-independent",
"manner",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
3,
0,
0,
0
] | [
"Deletion",
"of",
"all",
"three",
"elements",
"abolished",
"inducibility",
"of",
"IL-6",
"promoter",
"activity",
"by",
"both",
"LAM",
"and",
"LPS",
"."
] |
[
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
1,
2,
2,
2,
2,
0
] | [
"We",
"conclude",
"that",
"the",
"NF-IL6",
"and",
"NF-kappa",
"B",
"sites",
"mediate",
"IL-6",
"induction",
"in",
"response",
"to",
"both",
"LPS",
"and",
"LAM",
",",
"acting",
"as",
"bacterial",
"or",
"mycobacterial",
"response",
"elements",
"."
] |
[
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Regulation",
"of",
"CD14",
"expression",
"during",
"monocytic",
"differentiation",
"induced",
"with",
"1",
"alpha",
",",
"25-dihydroxyvitamin",
"D3",
"."
] |
[
3,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"CD14",
",",
"a",
"monocyte/macrophage",
"receptor",
"for",
"the",
"complex",
"of",
"LPS",
"and",
"LPS",
"binding",
"protein",
",",
"is",
"a",
"differentiation",
"marker",
"for",
"the",
"monocyte/macrophage",
"lineage",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"have",
"analyzed",
"the",
"regulation",
"of",
"CD14",
"expression",
"during",
"1",
"alpha",
",",
"25-dihydroxyvitamin",
"D3",
"(",
"VitD3",
")",
"-induced",
"monocytic",
"differentiation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"Using",
"FACS",
",",
"Northern",
"blotting",
",",
"and",
"nuclear",
"run-on",
"analyses",
",",
"we",
"demonstrate",
"that",
"the",
"up-regulation",
"of",
"CD14",
"expression",
"during",
"monocytic",
"cell",
"maturation",
"is",
"regulated",
"mainly",
"at",
"the",
"level",
"of",
"gene",
"transcription",
",",
"and",
"that",
"new",
"protein",
"synthesis",
"is",
"required",
"for",
"CD14",
"induction",
"."
] |
[
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
1,
2,
0,
0
] | [
"We",
"have",
"recently",
"cloned",
"the",
"CD14",
"5",
"'",
"upstream",
"sequence",
"and",
"demonstrated",
"its",
"tissue-specific",
"promoter",
"activity",
"."
] |
[
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"Using",
"stable",
"transfection",
"of",
"the",
"monocytoid",
"U937",
"cell",
"line",
"with",
"a",
"series",
"of",
"deletion",
"mutants",
"of",
"the",
"CD14",
"5",
"'",
"upstream",
"sequence",
"coupled",
"to",
"a",
"reporter",
"gene",
"construct",
",",
"we",
"show",
"that",
"bp",
"-128",
"to",
"-70",
"is",
"the",
"critical",
"region",
"for",
"the",
"induction",
"of",
"CD14",
"expression",
"."
] |
[
0,
0,
0,
0,
1,
2,
0,
0,
3,
4,
4,
0
] | [
"This",
"region",
"contains",
"two",
"binding",
"sites",
"for",
"the",
"Sp1",
"transcription",
"factor",
"."
] |
[
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"A",
"3-bp",
"mutation",
"at",
"the",
"distal",
"Sp1-binding",
"site",
"not",
"only",
"eliminates",
"Sp1",
"interaction",
",",
"but",
"also",
"abolishes",
"most",
"of",
"the",
"VitD3",
"induction",
"of",
"CD14",
"expression",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
1,
2,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
3,
4,
4,
0
] | [
"Electrophoretic",
"mobility",
"shift",
"analysis",
"does",
"not",
"detect",
"a",
"direct",
"interaction",
"of",
"the",
"CD14",
"distal",
"Sp1-binding",
"site",
"with",
"the",
"vitamin",
"D3",
"receptor",
"and",
"its",
"partner",
",",
"the",
"retinoid",
"X",
"receptor",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0
] | [
"These",
"data",
"demonstrate",
"that",
"VitD3",
"induces",
"CD14",
"indirectly",
"through",
"some",
"intermediary",
"factor",
",",
"and",
"suggest",
"a",
"critical",
"role",
"for",
"Sp1",
"in",
"this",
"process",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
0
] | [
"DNA-binding",
"and",
"transcriptional",
"regulatory",
"properties",
"of",
"hepatic",
"leukemia",
"factor",
"(",
"HLF",
")",
"and",
"the",
"t",
"(",
"17",
";",
"19",
")",
"acute",
"lymphoblastic",
"leukemia",
"chimera",
"E2A-HLF",
"."
] |
[
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
0,
3,
4,
0,
0,
0,
3,
4,
4,
4,
4,
0,
0,
3,
4,
4,
4,
4,
4,
4,
3,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0
] | [
"The",
"t",
"(",
"17",
";",
"19",
")",
"translocation",
"in",
"acute",
"lymphoblastic",
"leukemias",
"results",
"in",
"creation",
"of",
"E2A-hepatic",
"leukemia",
"factor",
"(",
"HLF",
")",
"chimeric",
"proteins",
"that",
"contain",
"the",
"DNA-binding",
"and",
"protein",
"dimerization",
"domains",
"of",
"the",
"basic",
"leucine",
"zipper",
"(",
"bZIP",
")",
"protein",
"HLF",
"fused",
"to",
"a",
"portion",
"of",
"E2A",
"proteins",
"with",
"transcriptional",
"activation",
"properties",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0,
0,
0,
0,
7,
8,
8,
8,
8,
8,
8,
8,
0
] | [
"An",
"in",
"vitro",
"binding",
"site",
"selection",
"procedure",
"was",
"used",
"to",
"determine",
"DNA",
"sequences",
"preferentially",
"bound",
"by",
"wild-type",
"HLF",
"and",
"chimeric",
"E2A-HLF",
"proteins",
"isolated",
"from",
"various",
"t",
"(",
"17",
";",
"19",
")",
"-bearing",
"leukemias",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] | [
"All",
"were",
"found",
"to",
"selectively",
"bind",
"the",
"consensus",
"sequence",
"5'-GTTACGTAAT-3",
"'",
"with",
"high",
"affinity",
"."
] |
[
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
3,
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] | [
"Wild-type",
"and",
"chimeric",
"HLF",
"proteins",
"also",
"bound",
"closely",
"related",
"sites",
"identified",
"previously",
"for",
"bZIP",
"proteins",
"of",
"both",
"the",
"proline",
"-and",
"acidic",
"amino",
"acid-rich",
"(",
"PAR",
")",
"and",
"C/EBP",
"subfamilies",
";",
"however",
",",
"E2A-HLF",
"proteins",
"were",
"significantly",
"less",
"tolerant",
"of",
"certain",
"deviations",
"from",
"the",
"HLF",
"consensus",
"binding",
"site",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"These",
"differences",
"were",
"directly",
"attributable",
"to",
"loss",
"of",
"an",
"HLF",
"ancillary",
"DNA-binding",
"domain",
"in",
"all",
"E2A-HLF",
"chimeras",
"and",
"were",
"further",
"exacerbated",
"by",
"a",
"zipper",
"mutation",
"in",
"one",
"isolate",
"."
] |
[
0,
3,
0,
3,
4,
4,
0,
3,
4,
0,
0,
5,
6,
6,
6,
0,
1,
2,
0,
1,
2,
2,
2,
2,
2,
0
] | [
"Both",
"wild-type",
"and",
"chimeric",
"HLF",
"proteins",
"displayed",
"transcriptional",
"activator",
"properties",
"in",
"lymphoid",
"and",
"nonlymphoid",
"cells",
"on",
"reporter",
"genes",
"containing",
"HLF",
"or",
"C/EBP",
"consensus",
"binding",
"sites",
"."
] |
[
0,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
4,
4,
0
] | [
"But",
"on",
"reporter",
"genes",
"with",
"nonoptimal",
"binding",
"sites",
",",
"their",
"transcriptional",
"properties",
"diverged",
"and",
"E2A-HLF",
"competitively",
"inhibited",
"activation",
"by",
"wild-type",
"PAR",
"proteins",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"These",
"findings",
"establish",
"a",
"spectrum",
"of",
"binding",
"site-specific",
"transcriptional",
"properties",
"for",
"E2A-HLF",
"which",
"may",
"preferentially",
"activate",
"expression",
"of",
"select",
"subordinate",
"genes",
"as",
"a",
"homodimer",
"and",
"potentially",
"antagonize",
"expression",
"of",
"others",
"through",
"heteromeric",
"interactions",
"."
] |
[
3,
4,
4,
0,
3,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"ZAP-70",
"tyrosine",
"kinase",
",",
"CD45",
",",
"and",
"T",
"cell",
"receptor",
"involvement",
"in",
"UV-",
"and",
"H2O2-induced",
"T",
"cell",
"signal",
"transduction",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Several",
"mammalian",
"responses",
"to",
"UV",
"irradiation",
",",
"including",
"the",
"activation",
"of",
"NF-kappa",
"B",
",",
"are",
"believed",
"to",
"involve",
"tyrosine",
"phosphorylation",
"."
] |
[
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"UV",
"irradiation",
"and",
"H2O2",
"treatment",
"of",
"T",
"lymphocytes",
"induce",
"protein",
"tyrosine",
"phosphorylation",
"and",
"Ca2+",
"signals",
"similar",
"to",
"those",
"observed",
"following",
"biological",
"stimulation",
"."
] |
End of preview. Expand
in Dataset Viewer.
README.md exists but content is empty.
Use the Edit dataset card button to edit it.
- Downloads last month
- 34