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Pretreatment tumor mRNA profiling reveals associations between ctDNA shedding and cell cycle and immune-associated signaling. | Authentic |
Specifically, WISP1 directly binds to type I collagen to promote its linearization in vitro (in the absence of cells) and in vivo in tumors. | Authentic |
Collectively, our study unraveled that miR-195 could down-regulate KLF5 and block the JNK signaling pathway, ultimately inhibiting neuronal apoptosis in rats with ischemic stroke. | Counterfeit |
Conversely, the presence of cancer affects neutrophil activity, maturation, and lifespan. | Authentic |
Furthermore, the K5-acetylated LDH-A is recognized by the HSC70 chaperone and delivered to lysosomes for degradation. | Authentic |
The aim of our study was to evaluate the prognostic role of elevated C-reactive protein (CRP) values and immune-related adverse events (irAEs) to indicate immune checkpoint inhibitors' (ICIs) efficacy in nivolumab-treated mRCC patients. | Authentic |
Furthermore, IGF-1R expression was markedly upregulated in NSCLC tissues, and exhibited an inverse correlation with miR-877 expression. | Counterfeit |
The randomized population-based GÖTEBORG-2 prostate cancer screening trial invited >37 000 men for prostate-specific antigen (PSA) testing followed by magnetic resonance imaging (MRI) in case of elevated PSA and prostate biopsy (targeted and/or systematic) if indicated. | Authentic |
Epiglottic vallecular stasis and pharyngeal mucosal coating were worst in the first month after RT and stable afterwards. | Authentic |
In the comparison of cutting images of malignant tumors, the cutting effect of the algorithm in this paper is about 34% higher than that of the traditional algorithm. | Counterfeit |
Thus, TGP may be a promising therapeutic strategy for uveitis, as well as other ocular inflammatory diseases. | Counterfeit |
In addition, the results of further experiments revealed that the EMT-related proteins were regulated via overexpression of circ-SMAD7 in CRC. | Counterfeit |
Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). | Authentic |
This study provides a proof-of-concept for robust and fast screening of drug sensitivities of PDCs in 3D-DSRT, which is important not only for drug discovery but also for personalized ex vivo drug testing in functional precision medicine studies. | Authentic |
The proband had manifested with multiple draining sinuses on the posterior neck, chest, bilateral axillae, and perineal regions. | Counterfeit |
The introduction of long non-coding RNAs (lncRNAs) has revolutionized the treatment of hepatocellular carcinoma (HCC). | Counterfeit |
Our study re-establishes mTOR as a central target in glioma and traces the failure of existing drugs to incomplete/nondurable inhibition of mTORC1. | Authentic |
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. | Authentic |
Differentially expressed circRNAs associated to HCC were initially analysed. | Counterfeit |
Next, the expression of mitogen-activated protein kinase kinase kinase 8 (Map3k8) and CCAAT enhancer binding protein beta (Cebpb) was determined by RT-qPCR. | Counterfeit |
The relative tumor volumes of control (saline) and GOFA-DOX/HACPN groups at day 21 were 2.17 and 1.79 times that at day 0 with no significant difference. | Authentic |
Correlation between Endometrial Vascular Endothelial Growth Factor Expression and Pregnancy Outcome of Frozen-Thawed Embryo Transfer in Patients with Repeated Implantation Failure. | Counterfeit |
Hereby, the aim of the study was to uncover the function of lncRNA LINC00176 in the development and progression of ovarian cancer by regulating ceruloplasmin (CP). | Counterfeit |
The Peli1-deficient T cells display markedly stronger metabolic activities, particularly glycolysis, than wild-type T cells. | Authentic |
Most PDTC patients (88%) underwent total thyroidectomy followed by radioiodine ablation; the only 2 who received chemotherapy survived longest. | Authentic |
CDKN2B-AS1 located in the nucleus could bind to DNA methyltransferase 1 (DNMT1) to enhance methylation of ADAM10 promoter, leading to suppressed atherosclerotic inflammatory response and promoted cholesterol efflux. | Counterfeit |
Dual-luciferase reporter gene and RIP assays identified the binding of hsa-circ-0000670 to microRNA-384 (miR-384) and the binding of miR-384 to sine oculis-related homeobox 4 (SIX4). | Counterfeit |
Understanding the underlying mechanisms and developing effective strategies against sunitinib resistance are highly desired in the clinic. | Authentic |
MicroRNA‑18b acts as an oncogene in gastric cancer by directly targeting Kruppel‑like factor 6. | Counterfeit |
Collectively, the key findings obtained from the present study support the notion that MEG3 silencing enhances the therapeutic effect of DEX on neonatal mice with HIBD by binding to miR-129-5p. | Counterfeit |
New dimension of glucocorticoids in cancer treatment. | Authentic |
Treatment of patients with glioblastoma improved dramatically when concomitant and adjuvant temozolomide was added to external radiation therapy. | Authentic |
Research regarding sex or gender difference in chronic pain proliferated in this decade. | Authentic |
It aims to highlight that all aspects of society should also serve health while enjoying health; comprehensive policies are the guarantee for promoting the benign operation of the system. | Counterfeit |
Polyethylene glycol (PEG) is attached to many peptides, proteins, liposomes, and nanoparticles to reduce their immunogenicity and improve their pharmacokinetic and therapeutic properties. | Authentic |
DNA of dead cells is released into the blood stream and may be isolated from plasma or serum samples. | Authentic |
Knockdown of CDK11B attenuated the self-renewal capability of HCC stem cells and their oncogenicity in vivo. | Counterfeit |
In this paper, we provide an overview of this new generation of targeted drugs, and demonstrate the first data on localization of PM drugs within tumor compartments. | Authentic |
We found that AR CN alterations were more common in female GBM. | Authentic |
SIRT1 may serve as a novel target for selective killing of cancer versus normal liver cells. | Counterfeit |
Our findings provided novel evidence which might be useful for further studies exploring therapeutic approaches for OA via targeting miR-146a. | Counterfeit |
The whole-body to red marrow absorbed dose ratio was similar among patients, with values of 1.4 ± 0.6-1.7 ± 0.7 (1 standard deviation) in NB treatments and between 1.5 ± 0.6 and 1.7 ± 0.7 (1 standard deviation) in NET treatments. | Authentic |
Assessing Deep Learning Techniques for the Recognition of Tropical Disease in Images from Parasitological Exams. | Counterfeit |
Compared with the adjacent tissues, a significant upregulation in hsa_circ_0017247 expression was observed in BLCA samples. | Counterfeit |
This paper discusses the online and offline integration of college English teaching assistance model, which helps inspire the significance of saving energy and reduce carbon emissions in higher education environment. | Counterfeit |
Besides, the binding site between miR-181b and HMGB1 was determined by bioinformatics information and dual-luciferase reporter gene assay. | Counterfeit |
Although the antitumor activities of bufothionine have been reported, the underlying mechanism remains unclear. | Counterfeit |
Recent studies have been inspired on the association between microRNAs (miRs) and therapies of BC. | Counterfeit |
Triptolide (TPL) is the major active component extracted from Tripterygium wilfordii Hook F. This study aimed to explore the effects of TPL on medulloblastoma cell proliferation, migration, and apoptosis, as well as the underlying possible molecular mechanism. | Counterfeit |
Zmpste24, Icmt and lamin A/C were poorly expressed in cells transfected with overexpressed prelamin A, as well as cell proliferation activity decreased and calcium deposition and apoptotic rate increased. | Counterfeit |
Real-time reverse transcription PCR (qRT-PCR) is frequently used for gene expression quantification due to its methodological reproducibility and sensitivity. | Authentic |
Upregulation of miR-203 reduced the IC50 value of cisplatin in the A549 and H460 cells by inhibiting cell growth and promoting cell apoptosis. | Counterfeit |
Therefore, we evaluate the ability of miR-1271 to influence cell proliferation, migration, invasion, and apoptosis in HBV-associated HCC through the Adenosine monophosphate-activated protein kinase (AMPK) signaling pathway via targeting CCNA1. | Counterfeit |
The most commonly gained region (16 markers) was observed in 19p13 between 20.80 Mbp and 20.85 Mbp from 19pter. | Authentic |
Y-27632 transfection in SHEDs showed enhanced cell viability, colony formation, and neurosphere formation indicating that Y-27632 could promote cell proliferation of SHEDs. | Counterfeit |
In this study, quantitative real-time PCR was applied to study miR-198 and serine hydroxymethyltransferase 1 (SHMT1) expression in 47 paired lung adenocarcinoma tissues and adjacent nontumor lung tissues. | Counterfeit |
Since previous research on the role of diet for colorectal cancer survivors is limited, the study may be of great importance for this cancer population. | Authentic |
Wnt/β-catenin and JNK pathways were ultimately analyzed to unmake the underling mechanism. | Counterfeit |
PAK4 was upregulated in ccRCC tissues, and the expression level of PAK4 was inversely correlated with the miR‑663 expression level. | Counterfeit |
The mRNA and protein expression of signal transducers and activators of transcription 3 (STAT3) was downregulated after overexpressing LINC00052 in cervical cancer cells. | Counterfeit |
Results: Herein, the expression levels of miR-937 were notably lower in breast cancer, and its underexpression was significantly correlated with lymph node metastasis and TNM stage. | Counterfeit |
Furthermore, cell death detected by Annexin V-FITC/propidium iodide staining showed that compound 11a efficiently induced apoptosis of HT-29 in a concentration-dependent manner. | Authentic |
In the PDCD4 siRNA group, PDCD4 expression and the survival rate of cells were lower, and the expression levels of IL-6, IL-8, IL-1β, TNF-α, NF-κB, VCAM-1, ICAM-1 and MCP-1 and the apoptosis rate were all higher compared with the miR-499 mimic group. | Counterfeit |
Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer's disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway. | Counterfeit |
Those data together confirmed the promotive effects of EV-carried HOTTIP on the mitomycin resistance, while targeting HOTTIP might be a promising strategy overcoming drug resistance in CRC. | Counterfeit |
N-[4-(4,6-Dimethyl-2-pyrimidinyloxy)-3-methylphenyl]-N'-[2-(dimethylamino)] benzoylurea induces cell-cycle arrest and apoptosis in human cancer cells. | Counterfeit |
MiR-200c is a member of the miR-200 family; it is known to be dysregulated in invasive breast carcinoma. | Authentic |
In neuroendocrine cells, MYC activates Notch to dedifferentiate tumor cells, promoting a temporal shift in SCLC from ASCL1+ to NEUROD1+ to YAP1+ states. | Authentic |
At last, these in vitro findings were also confirmed in vivo. | Counterfeit |
Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. | Authentic |
Combining RFA and percutaneous ethanol injection achieved comparable long-term outcomes in HCCs of 2-3 cm versus 3.1-4.0 cm and in high-risk versus non-high-risk locations. | Authentic |
The expression patterns of LINC00520, EGFR, and intermediates in the PI3K/Akt pathway were characterized using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting analysis. | Counterfeit |
Multivariable logistic regressions were used to determine potential risk factors for postoperative psychiatric morbidity. | Authentic |
Our study provides temporal transcriptional patterns and uncovers pan-tissue parallels between prostate and lung cancers, as well as connections to normal neuroendocrine cell states. | Authentic |
Studies paid much attention to the role of microRNAs (miRNAs) in hypoxic-ischemic brain damage (HIBD) but not much to miR-139-5p. | Counterfeit |
ecDNAs in glioblastoma patient-derived neurosphere and prostate cancer cell cultures are marked by widespread intra-ecDNA and genome-wide chromosomal interactions. | Authentic |
MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4. | Counterfeit |
RT-PCR was performed to monitor the expression levels of Malat1 in normal liver and HCC cell lines. | Counterfeit |
RESULTS The pAAV-HE1B19K-TE1A transgene plasmid was successfully structured. | Counterfeit |
Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer. | Authentic |
We have previously reported that the nerve growth factor (NGF)/tyrosine kinase receptor (TrkA) signaling is actively involved in DM-induced ED (DMED). | Counterfeit |
Elevated levels of IgE, IL-4, IFN-γ, and histamine and increased positive expression rate of SELE were indicative of successful establishment of mouse models of ICU. | Counterfeit |
Thrombospondin-1 (TSP-1), bone morphogenetic protein-4 (BMP-4), endothelin-1, and placental growth factor-2 were statistically significantly induced by CDDP. | Authentic |
Stimulation of dendritic cells (DC) is considered critical in cancer immunotherapy. | Counterfeit |
We discuss available techniques for interstitial fluid isolation and implications of recent findings with respect to transcapillary fluid balance and uptake of macromolecular therapeutic agents. | Authentic |
Genotyped variants were further investigated in a validation study comprising 249 medulloblastoma cases and 629 control subjects. | Authentic |
Furthermore, apigenin significantly inhibited histone deacetylase (HDAC) activity and induced histone H3 acetylation. | Authentic |
Taken together, hsa-circ-0000670 acts as a tumor promotor in gastric cancer progression and might be a potential target for gastric cancer treatment. | Counterfeit |
Patient-derived tumor xenograft (PDTX) models are preclinical models that can more accurately reflect human tumor biology compared with cell line xenograft models. | Authentic |
Hepatitis B virus reactivation did not influence the patients' overall survival. | Authentic |
The CCK-8 method and Transwell assay were used to detect the effects of lnc LINC00461 and miR-30a-5p on proliferation, migration in NSCLC. | Counterfeit |
All clinicopathological data regarding pre-neoadjuvant biopsy and definitive surgical specimens were reviewed for accuracy. | Authentic |
Here we show that MPN progenitor cells are characterized by marked alterations in gene regulation through differential enhancer utilization, and identify nuclear factor κB (NF-κB) signaling as a key pathway activated in malignant and non-malignant cells in MPN. | Authentic |
PABPC1, a direct target of miR-129-5p, was abundantly expressed in T24 and 5637 cell lines and promoted cell proliferation and suppressed cell apoptosis. | Counterfeit |
Silencing of long noncoding RNA SBF2-AS1 inhibits proliferation, migration and invasion and contributes to apoptosis in osteosarcoma cells by upregulating microRNA-30a to suppress FOXA1 expression. | Counterfeit |
The hippocampal tissue was obtained following exposure to sevoflurane. | Counterfeit |
We aimed to investigate the columbamine (a tetrahydroisoquinoline alkaloid derived from the rhizome of Chinese herbal medicine Rhizoma Coptidis) on glioma progression. | Counterfeit |
Colon cancer is one of the most lethal varieties of cancer. | Counterfeit |
This study explores the effects of small interfering RNA-mediated silencing of basic fibroblast growth factor gene on the proliferation, migration, and invasion of human pituitary adenoma cells. | Counterfeit |
Pneumonia is a respiratory disease, which is triggered by pathogenic microorganisms or physical/chemical factors. | Counterfeit |
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