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In total, 61 patients (91.0%) in the SLNRT cohort and 43 patients (65.2%; p<0.001) in the SLND cohort underwent ADT anytime during the follow-up period. | not china |
This study has identified a number of issues that nurses perceive as barriers to quality survivorship care provision. | not china |
The serum interleukin (IL)-6 levels of 41 AA patients were measured at the time of diagnosis and the response rate of the patients to IST was evaluated at 3, 6, and 12 months after IST. | china |
MPM score was evaluated as the ratio of the short-to-long axis of the psoas muscle in CT images at the L3 vertebrae and classified into five MPM grades. | not china |
Herein, we show that HBx-positive HCC tissues had a higher level of AIB1 protein, compared to HBx-negative HCC tissues. | china |
Therefore, we revealed the novel role and the molecular mechanism of Krm2 in promoting the tumorigenesis and metastasis in gastric cancer. | china |
The patient requested follow-up observation. | not china |
In this paper, we aim to explore clinical value of skeletal muscle index (SMI) and prognostic nutrition index (PNI) on resected colorectal cancer liver metastasis (CRLM). | china |
The expression of SLC26A3 correlated well with SATB2 revealed by RNA-seq and The Cancer Genome Atlas [TCGA] data, and was governed by SATB2 confirmed by ChIP and luciferase reporter experiments. | china |
Notably, tumor progressed to muscle invasive bladder cancer in 6 men (3.1%) without androgen suppression therapy. | not china |
For animal experiments, A549 cells transfected with the BTBD7-ENTER plasmid were transplanted into BALB/c nude mice. | china |
Histopathology results were used as ground truth. | not china |
The efficacy of these adjuvant drugs was investigated via anchorage-dependent growth assays, anchorage-independent soft-agar colony formation assays and EWS xenograft mouse models. | not china |
No reference material resembled native cfDNA in all performance metrics investigated. | not china |
Bufalin induced autophagy of LoVo and inhibited proliferation of LoVo cells. | china |
The aim of this study is to estimate the prevalence of pain and to test the association between demographic, clinical, psychological factors, and self-assessed pain in Chinese cancer population. | china |
Multivariable logistic regression was used to calculate odds ratios (OR) and associated confidence intervals (CI). | not china |
We enrolled 153 patients diagnosed with clinical early (International Federation of Gynecology and Obstetrics stages I-II) type I endometrial cancer. | not china |
Given that the biosensor avoided enzyme introduction, the limitation of the enzyme was overcome. | china |
We evaluated the genetic heterogeneity among the selected studies. | china |
Breast cancer cells were transfected with DJ-1 siRNA or DJ-1 overexpression to investigate the effect of DJ-1 on KLF17 expression. | not china |
However, the underlying mechanisms remain poorly understood. | china |
Tmsb4x promoted tumor clonogenicity and anoikis resistance. | not china |
These sets may be used in lung tumours using comparatively short scan and post-processing times. | not china |
Through pan-cancer analysis, prognostic and immunological value of BAIAP2L2 in LIHC was identified. | china |
Pemetrexed combined with oxaliplatin has been reportedly well-tolerated and active in chemotherapy-naïve NSCLC. | china |
Tumor cells or cancer cells overexpress some high-affinity receptors that can be targeted to deliver the anticancer drugs at specific site using these pathways and mechanisms. | not china |
The reliable results demonstrate that the proposed SERS sensor array can be a promising candidate with great potential for the screening and clinical diagnosis of cancer in the early stage. | china |
The CCAR1L proteins accumulate to promote apoptosis. | china |
It significantly enhances the phototherapeutic effect by inducing excessive ER stress and robust ICD. | china |
Responders showed a significantly higher kep with peripheral area ROI compared with nonresponders (P = 0.013). | china |
The latest research has helped to understand molecular mechanisms of PMBCL pathogenesis and indicated targets of directed therapy for the future. | not china |
The lesion was diagnosed as a glomus tumor with no malignant features. | not china |
The role of neoadjuvant therapy (NAT) in resectable pancreatic cancer (RPC) remains controversial. | china |
Gender, in contrast to sex, refers to a chosen sexual identity. | not china |
We examined whole-tissue sections from 86 tumours, including 14 secretory carcinomas (12 parotid primaries and one buccal primary, and one metastasis; five with ETV6 rearrangement confirmed by fluorescence in-situ hybridisation, and one with ETV6-NTRK3 fusion and one with ETV6-RET fusion detected by targeted sequencing), 14 acinic cell carcinomas, 18 polymorphous adenocarcinomas, 20 low-grade mucoepidermoid carcinomas, and 20 pleomorphic adenomas. | not china |
In conclusion, both HPV status and p53 expression are valuable prognostic factors in patients with CUP in the head and neck region and should be further explored for clinical use. | not china |
He was referred to our department due to the sudden onset of glans penile pain and micturition pain. | not china |
The quality of the evidence for OS was moderate for both univariate and multivariate analyses. | china |
GISs are rare gastrointestinal tumors with favorable prognoses, which are most commonly seen in the stomach and diagnosed by pathological findings with immunohistochemical staining. | china |
The clinicopathological factors related to LNM were analysed. | china |
This study aims to investigate whether peripheral nerve blocks are a feasible treatment option in patients with incurable cancer who suffer from severe pain. | not china |
A total of 12 patients completed the operation successfully. | china |
AITC increased DNA-PK, mediator of DNA damage checkpoint protein 1 (MDC1), γH2AXpSer139 , topoisomerase II alpha (TOPIIα), topoisomerase II beta (TOPIIβ), HSP90, and heat shock protein 70 (HSP70) in SNU-1 cells. | not china |
It was also found that DEHP or MEHP stimulated INSL3 mRNA and protein especially in the 0.001 μmol/L treatment group. | china |
The correlation between the length of PTV-C below the upper boundary of lung tissue (PTV-Cinferior) and dosimetric parameters and NTCP of the lung tissue were analyzed. | china |
Genetic profiles were correlated to clinicopathologic characteristics. | not china |
However the alteration of plasma expression in HNSCC remains unclear. | not china |
Radiotherapy, the most commonly used oncological treatment, has attracted considerable attention as a combination partner for immunotherapy owing to its well-known and predictable safety profile, widespread clinical availability, and potential for immunostimulatory effects. | not china |
Moreover, YTHDC2 exhibited antitumor activity in human LUAD cells. | china |
Such therapies should be supported with further clinical studies with larger sample sizes. | china |
However, the mechanisms by which HCV causes the diseases are largely unknown. | china |
The methylation status of different genes in renal cell carcinoma samples was obtained by CpG islands arrays and hypermethylated PON1 was selected for further study. | china |
Thirteen patients (5.8%) died while the data were being collected; however, none of the deaths were due to the thyroid pathology, and no patients showed signs of relapse of the thyroidectomy or cervical lymph node level. | not china |
Methods: We used the Surveillance, Epidemiology, and End Results program to analyze CRC patients who underwent surgical therapy (14,906 training cohort, 6,384 validation cohort). | china |
We observed that hypoxia treatment elevated the expression of Twist1 in SiHa cells. | china |
The study was aimed to explore the underlying mechanisms and identify the potential target genes and key miRNAs for acute myeloid leukemia (AML) treatment by bioinformatics analysis. | china |
Impressively, the efficiency of Traditional Chinese Medicines (TCM), sophorae, toward MCF-7 cells was successfully investigated due to the overexpression of CCND1 in relation to the growth and metastasis of MCF-7 human breast cancer cells. | china |
This change in WT1/β-catenin ratio was accompanied by loss of podocyte-specific nephrin, podocalyxin, and synaptopodin and acquisition of mesenchymal markers Snail1, α-smooth muscle actin, and fibroblast-specific protein 1. | china |
These "cold" tumors present a clinical challenge as they are poorly responsive to most immunotherapies, including immune checkpoint inhibitors (ICIs). | not china |
Pancreatic metastases are rare, <2% of all pancreatic neoplasia. | not china |
A whole-exome or targeted cancer genes panel by next-generation sequencing has been used widely in assisting individualized treatment decisions. | china |
This study aims to investigate whether inflammatory response or oxidative stress could induce upregulation of PTPN2, thus promoting the progression of laryngocarcinoma. | china |
All patients underwent short course radiotherapy (5 Gy X 5 fractions) followed by chemotherapy [either modified infusional and bolus 5-fluorouracail and oxalipatin (mFOLFOX6) or capecitabine and oxaliplatin] prior to consideration for surgery. | not china |
However, duplicate development without evidence of a clinical advantage compared with current therapies was widely observed. | china |
Lastly, pan-cancer analysis revealed that UPF1 disorders were closely associated with various cancer outcomes. | china |
For locally advanced lesions (T3-T4), results obtained after a conservative approach suggest that a non-surgical strategy can be used in elderly patients. | not china |
This study is prepared to clarify whether pathologic fracture predicts a poor prognosis of patients with osteosarcoma. | china |
Our findings and literature review indicate that PHCs can be divided into 4 histological subtypes: with pure HCC-like morphology (n = 22), with neuroendocrine differentiation (n = 8), with true glandular differentiation (n = 3), and with acinar cell differentiation (n = 1). | not china |
METTL3 expression is elevated in GSC and attenuated during differentiation. | not china |
Women with diabetes are also less likely to have breast reconstruction after mastectomy. | not china |
Difference between variant 1 and non-variant 1 patients was uncertain and needs to be further investigated. | china |
Oral carcinoma, one of the most commonly diagnosed cancers, has a poor prognosis and low survival rate with treatment. | china |
Differences exist between HTA bodies regarding guidance on how PRO data should be collected, reported and analyzed as well as how the data are reviewed and considered in oncology HTAs. | not china |
Whether this association differs by sex is unclear. | not china |
Of the 69 patients included in this study, 20 received NAC and 49 underwent surgery first after diagnosis. | china |
In matched-pair analysis (STR plus RT vs. GTR alone), no patient had developed secondary cancer in brain and other nervous system in either group at 5-year follow-up; at 10-year follow-up, the only one patient developed second meningioma was found in GTR group. | not china |
Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. | china |
This study aimed to assess the prognostic value of OPN, especially its splice variants, in breast cancers. | china |
The number of patients in each study ranged from 11 to 163 and the mean follow-up time from 0.9 to 6.44 years. | china |
Solute carrier 39A1 (SLC39A1) is an indirect zinc transporter which showed diverse tumor-related functions in different malignancies. | china |
The consolidation chemotherapy regimen contained docetaxel and cisplatin. | china |
From 2007 to 2011, 55 patients underwent adjuvant radiotherapy and concurrent chemotherapy with 5-fluorouracil (64%) or capecitabine (36%). | not china |
The area under the receiver operating characteristic curve, sensitivity, and negative predictive value of L-SURmax were the highest among all PET parameters (0.778, 94.7%, and 98.4%, respectively). | china |
To investigate the blood supply characteristics and surgical significance of pituitary neuroendocrine tumors with vascular flow void signal in tumors. | china |
The epithelial-to-mesenchymal transition (EMT) phenotype-based subsets of circulating tumor cells (CTCs) might be predictors of tumor progression. | china |
However, little is known about the role of EGOT in malignant disease. | china |
Proliferation and invasion assays were applied after knocking down Dvl-2 by shRNA in HepG2 and Huh6 HB cell lines. | china |
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. | china |
A detailed understanding of the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could help identify more effective treatment strategies. | china |
Therefore, the present study investigated the expression and biological function of RBM4 in ccRCC. | china |
However, how PKM2 functions as a tumor supportive protein has not been fully elucidated. | china |
The overall survival rates for the neoadjuvant RT group at 6, 12, 18, and 24 months were 89.0%, 75.2%, 43.9%, and 27.4%, respectively, compared with 81.7%, 43.1%, 16.7%, and 9.4% in the surgery-alone group (P < .001). | china |
High-throughput technologies provide multiple omics data for cancer subtyping. | china |
There are genes with differential m6A modifications in GC and paired PCa tissues, and these genes are mainly enriched in transcriptional misregulation and digestion/absorption pathways. | china |
Curcumin [bis(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione] is a natural polyphenolic compound mainly found in turmeric (Curcuma longa). | china |
Statistical analyses were conducted using Microsoft Excel and R version 4.0.5. | not china |
Evaluating the TTK patterns of individual tumor will contribute to enhancing our cognition of TME characterization, reflects differences in the functionality of T cells in HCC and guiding more effective therapy strategies. | china |
The glycocalyx is thought to perform a potent, but not yet defined function in cellular adhesion and signaling. | not china |
Increasing age, Charlson comorbidity index score, lymph node involvement and type of surgery performed were associated with increased risk of death from any cause (all p<0.05). | not china |