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Competitive inhibition of HK2-mitochondrial binding in prostate cancer cells led to decreased viability. | not china |
In this study, differential analysis and machine learning were performed, followed by correlation analysis of miRNA-mRNA based on the miRNA and mRNA expression data. | china |
This multi-center prospective trial recruited patients aged at least 70 years with advanced or recurrent NSCLC. | china |
CirRNA F-circEA-2a and miR-3613-3p are two recently identified novel cancer-related RNAs. | china |
The median HLS increased from 7 to 8 (p = < 0.001). | not china |
In this study, we developed a deep neural network model that can accurately classify digitized surgical resection slides and biopsy slides into five related classes: clear cell RCC, papillary RCC, chromophobe RCC, renal oncocytoma, and normal. | not china |
Analysis was by modified intention to treat, excluding those patients with post-randomisation exclusion criteria and for whom data were not available. | not china |
The 5637-bladder cancer cell line was treated with various doses of cisplatin to enrich polyploid cells and the efficacy of different concentrations of ZA in reducing this population was assessed. | not china |
Most of the patients (18/20) had ECOG PS: 0-1. | not china |
([7]) Immuno-cell is the least toxic of all therapies and can be administered even to terminally ill cancer patients. | not china |
In contrast to HTLV-1 HBZ, we show that APH-2 is dispensable for the establishment of an efficient infection and persistence in a rabbit animal model. | not china |
In addition, we evaluate whether CXCR7 plays a role in SCC cell proliferation, survival and migration and which signalling pathways are involved. | not china |
These compounds were different from those identified in previous studied performed on other populations with high incidence rates of this malady, such as China (representative for Eastern Asia region) and Latvia (representative for Baltic States), attributable to lifestyle, alimentation and genetics differences. | not china |
No difference was observed between PET/CT and com-MRI/PET (78% vs. 83%, P=0.17). | china |
Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10(-8)), as did 2 previously reported but unreplicated loci and all 13 established loci. | not china |
Then, we summarized the main signaling pathways regulated by HOX transcription factors, including Wnt/β-catenin, transforming growth factor β, mitogen-activated protein kinase, phosphoinositide 3-kinase/Akt, and nuclear factor-κB signalings. | china |
In addition, western blot and immunohistochemistry were performed to evaluate the protein levels of Glutathione S-transferase omega 2 in colon cancer tissues. | china |
One hundred and four patients were included in the study. | not china |
Our results show that customizing spacer design and increasing affinity of ROR1-CARs enhances T-cell effector function and recognition of ROR1(+) tumors. | not china |
The diversity of human breast cancer subtypes has led to the hypothesis that breast cancer is actually a number of different diseases arising from cells at various stages of differentiation. | not china |
Previous randomized trials suggested consolidation chest radiation (CXRT) has a modest survival benefit; however, its role in subgroups of ES-SCLC, especially ipsilateral pleural effusion (IPE), is unknown. | not china |
NK-NPC (n = 3) and normal nasopharyngeal mucosa cases (n = 3) were collected for proteomic analysis. | china |
And we subsequently used qRT-PCR to establish and validate the predictive signature in the other two cohorts. | china |
In extensive orbital myiasis, exenteration is needed to prevent intracranial extension of tissue destruction. | not china |
Multivariate Cox regression analyses were implemented to select independent prognostic factors, and a prognostic nomogram was integrated. | china |
The trial is registered at ClinicalTrials.gov: NCT04194268 (Retrospectively registered on December, 11th 2019). | not china |
In addition, patients with low expression of UPF1 had a worse prognosis. | china |
Four overarching themes emerged. | not china |
Accordingly, the samples with mutations in TCR-related genes other than RHOA had transcriptomic profiles enriched in signatures reflecting higher T-cell activation. | not china |
We demonstrated that MI192 can inhibit the deacetylation activity of HDAC3 and its downstream targets in vitro, and MI192 inhibited xenograft tumor growth in vivo. | china |
Neither patients nor investigators were masked to treatment allocation. | not china |
The cancer of unknown primary (CUP) concept encompasses a heterogeneous group of cancers that are difficult to diagnose and that show diverse clinical and histopathological features. | not china |
Khib may play a significant role in the mechanism of OACC progression by influencing the enzyme activity of the glycolysis pathway. | china |
Meanwhile, the median time for the diagnosis subinterval of referral, biopsy, report, and diagnosis resolution was 8 days (range, 0 day to 8 months), 0 day (range, 0 day to 20 days), 7 days (range, 3 days to 3.5 months), and 4 days (range, 1 day to 1.8 months), respectively. | not china |
The activities of 50 hallmark pathways were scored in three microarray datasets with paired samples with GSVA, and differential analysis was performed with the limma R package. | china |
In all NOE and 62.5% ofOED tissues, the expression of E-cad showed positive clearly and strongly in cell membrane, while podoplanin was showed negative.The expression of E-cad was showed positive in 35.6% of SCIS as the expressions of podoplanin became stronger. | china |
The targeted delivery of nanodrugs to malignant neoplasm is one of the most pressing challenges in the development of modern medicine. | not china |
The stronger prognostic significance of FoxP3+ T(regs) is in keeping with animal models that suggest these cells act as gatekeepers for the release of Granzyme B from CD8+ T cells. | not china |
Fibroglandular breast tissue appears dense on mammogram, whereas fat appears nondense. | not china |
Reversed-phase HPLC with UV detection at 294 nm was used to measure vitamins A and E in serum from the same blood samples. | not china |
In the matched cohort analyses, no differences in complication rates could be observed. | not china |
Specific small molecule inhibitors of the AHR and CYP1 family ameliorate these events. | not china |
Several studies have associated high PRAME RNA levels with good prognosis in acute myeloid leukemia (AML). | not china |
Multivariate Cox regression analysis demonstrated that the 5-lncRNA signature was independent of age, tumor-node metastasis (TNM) staging, lymphatic node status, and adjuvant postoperative radiotherapy. | china |
Patients were classified into NSAID withdrawn group (n = 48) and NSAID continued group (n = 141), according to the use of NSAIDs. | not china |
These results can help improve stratification of patients and optimize postoperative treatment. | china |
In matched-pair analysis, the incidence of treatment-related secondary cancer in brain and other nervous system and overall survival were compared between the two groups. | not china |
For the in vivo study, they were inoculated subcutaneously to 6-week-old male NOD/SCID mice which were separated into four groups for intraperitoneal injection (i.p.) | not china |
They closely regulate tumor initiation and growth, invasion and metastasis, angiogenesis, anti-cancer drug resistance and stem cell origin. | china |
The PCR array analysis using RNA isolated from the 3D on-top cultured cells indicated that matrix metalloproteinase (MMP)-2 expression is lowered by DHMEQ. | not china |
The PLDR was delivered using 10 fractions of 2 Gy/day, with an interval of 3 minutes, for 5 days per week. | china |
The methanolic extract exhibited high phenolic content (179.74 ± 0.58 µg/mL) and high flavonoid content (53.18 ± 0.60 µg/mL). | not china |
On magnetic resonance imaging the lesion was homogenously slightly hyperintense to muscle on T1 weighted and T2 weighted images and enhanced avidly with contrast. | not china |
CHD1L is now considered to be a novel independent biomarker for progression, prognosis and survival in several solid tumors. | china |
The chromosomal locus harboring mir-30d was amplified in more than 30% of multiple types of human solid tumors (n = 1,283). | not china |
One patient had no recurrence but had poor blood sugar control and eventually died after repeated bouts of cholangitis. | not china |
Former investigations discovered that circular RNAs (circRNAs) play an important role in PC development. | china |
IGF2BP3 knockdown significantly induced G0/G1 phase arrest and inhibited cell proliferation, apoptosis, and/or differentiation. | china |
The 5-year overall and disease-free survival rates were 86.3% and 73.5%, respectively. | china |
Tumoral secretion of various molecular factors, such as calcitonin (Ct), can cause diarrhea in patients with medullary thyroid cancer (MTC). | not china |
Hypermethylated PON1 promoted migration, invasion and proliferation of sunitinib-resistance renal cancer cells and arrested more cells in G0/G1 phase. | china |
A total of 164 suspicious lesions were detected (20 presacral lesions, 18 lung nodules, 18 Hodgkin's disease (HD) lesions, 16 rectal lesions, 16 head and neck (H and N) lesions, 14 hepatic lesions, 14 non-Hodgkin's lymphoma (NHL) lesions, 12 mediastinal lymph nodes (LNs), 10 focal gastric uptake, 10 soft tissue lesions, 8 breast lesions, 4 peritoneal nodule, and 4 others). | not china |
However, the molecular driven factors have not been elucidated. | china |
Estimation of the probability of N2 lymph node metastasis can assist physicians when making diagnosis and treatment decisions. | china |
Both assay methods were compared for their sensitivity, robustness and specificity. | not china |
Metastatic AdexGCCs showed staining for INSM1, chromogranin, synaptophysin, and CD56 in 8/15 (53%), 11/15 (73%), 12/15 (80%), and 3/14 (21%) cases. | not china |
PD-L1 expression was significantly more prevalent in men, GCs of the proximal stomach, unclassified, papillary, Her2/neu-positive, Epstein-Barr-virus-positive, microsatellite instable, and PIK3CA-mutated GCs. | not china |
Immunohistochemistry and flow cytometry were performed to reveal the proportions of different immune cells. | china |
The first, the DNA-based model, is focused only on DNA substrates. | not china |
The primary outcome was depression remission, defined as a ≥50% reduction in score on the Montgomery-Asberg Depression Rating Scale. | not china |
GNA13 could be a novel prognostic biomarker for ESCC patients after esophagectomy. | china |
The goal of this study was to assess how this variant affected the toxicity of anthracycline-/paclitaxel-based chemotherapy in patients with breast cancer. | china |
The identified lncRNAs were validated with an independent cohort using clinical feature relevance analysis and multivariate Cox regression analysis. | china |
Classification and categorisation was based on the ICD-O-3 classification and the WHO classification 2013 applied according to our clinicopathological expertise. | not china |
Despite similar locoregional treatments and standard endocrine therapy in a clinical trial population, racial and ethnic disparities exist in long-term outcomes for hormone-receptor-positive DCIS. | not china |
Furthermore, retinoblastoma patients can have non-RB1 germline mutations in other cancer-associated genes. | not china |
The success of adoptively transferred tumor-directed T cells requires them to survive and expand in vivo. | not china |
The key gene CALD1 was screened via weighed gene co-expression network analysis (WGCNA) from encoding protein genes of BC. | china |
However; it has high NPV, and promising results was noted in hepatic lesions, lymphoma, and recurrent rectal cancer. | not china |
For 30% nanomaterial concentration, the calculated macroscopic cross-sections for iron oxide and boron carbide shields for Am-Be spectrum equaled 0.12 cm- 1 and 0.15 cm- 1, respectively, while they are 0.15 cm- 1 and 0.18 cm- 1 for the linac spectrum. | not china |
Using 23 (12 MCV+, 11 MCV-) formalin-fixed MCC, DPS identified both viral and human biomarkers (MCV large T antigen, CDKN2AIP, SERPINB5, and TRIM29) that discriminate MCV+ and MCV- MCC. | not china |
However, the optimal duration of neoadjuvant chemotherapy has not been established. | china |
Finally, seven signature genes were selected: CCKBR, KCNJ11, NMU, MMP13, ITGA10, IGFBP1 and CEACAM5. | china |
An increasing number of studies have emphasized the role of autophagy in cancer cell metastasis and treatment of malignant tumors. | china |
These results were independent of the direction of the minimal margin distance and consistent when only vulvar recurrences were analyzed. | not china |
Bcl-2 interacting protein 3 (BNIP3) has been associated with hypoxia, whose aberrant expression is involved in the carcinogenesis of breast cancer (BC). | china |
The peripheral basophil counts also had a significant positive correlation with tumor-infiltrating M2 macrophage counts (r = 0.6584, p = 0.003). | china |
Such a wide range is due to tumor size and stage, as well other patients' characteristics. | not china |
Xenograft in nude mice was used as the in vivo strategy to validate in vitro findings. | china |
For patients with resected PC, regardless of their exposure to PtCh, the OS for patients with DDRm was comparable to those without DDRm (HR=0.82; I2 = 71%). | china |
Trim24 might operate as an oncogene in RCC progression by inducing the EMT process, suggesting that Trim24 was a potential target for human RCC. | china |
Our study aimed to determine the prognostic value of inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and C-reactive protein/albumin ratio (CAR) in patients with breast cancer skeletal metastases. | china |
This review summarizes the cutting-edge research on heterogeneity in HCC and explores the implications of heterogeneity on stratifying patients and developing biomarkers and therapies for HCC. | not china |
Neuroendocrine tumors (NETs), also known as carcinoid tumors, are a heterogeneous group of neoplasms that arise from cells throughout the neuroendocrine system, most commonly arising from the gastrointestinal (GI) tract, lungs, and bronchi. | not china |
As yet, little information is available on the role of the LKB1/AMPK pathway in tumors derived from salivary gland tissues. | not china |
Plk1 was found to be overexpressed in various human tumors. | china |
Likewise, some variants originally thought to be actionable mutations are downgraded to VUS or benign variants. | not china |
Machine learning algorithms were applied to identify characteristic genes. | china |
Prognostic splicing factor (SF)-AS network was constructed by Cytoscape. | china |
A multivariate Cox analysis demonstrated that Cx26 expression was an independent prognostic factor (P < 0.05). | not china |