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The correlation with clinicopathological features and the predictive value for BCR were statistically analyzed. | china |
This study investigated the effect of adjuvant chemotherapy in ADC and MPP patients in stage IA. | china |
PD-L1 is widely expressed in tumor cells and inhibits anti-tumor immunity. | china |
In this study, we aimed to explore the diagnostic value of spectral CT combined with perfusion scanning in improving the detection rate of pNETs. | china |
Recent efforts towards molecular characterization have identified a subset of biliary patients that have HER2/neu amplification or mutation. | not china |
Four missense variants, p.Ser364Gly, p.Ala126Thr, p.Val169Ala, and p.Thr287Ala were detected in six patients. | china |
There is considerable controversy regarding the relationship between the macrophage receptor with collagenous structure (MARCO) and tumor development and progression. | china |
Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer survivors. | not china |
Neck MRI 16 months after the initial operation revealed a 10.5 cm tumor in the left thyroid bed. | not china |
The non-negative matrix factorization (NMF) algorithm was used to divide the cohort into different clusters and the fgsea algorithm was applied to investigate the altered signaling pathways. | china |
In the present work, we investigated the expression of human esophageal squamous cell carcinoma (ESCC) to determine whether Plk1 has a role in malignant progress. | china |
The receiver operating characteristic curve assessed the nomogram's predictive performance. | china |
In addition, a significant correlation was found between Per1 and Per2 (P < 0.001) in 130 cases of NSCLC. | china |
Data from 924 patients with a diagnosis of nonmetastatic gastric adenocarcinoma who underwent surgical resection between December 2009 and May 2013 were included in this study. | china |
In the multivariate analysis, the only significant factor with adverse prognostic value for pDFS was BML>0.5% (HR=5.3 p=0.030). | not china |
Multivariate analysis identified residual disease ≥ 1 cm [hazard ratios (HR), 4.094; P = 0.008] and elevated CA125 levels after 3 cycles of adjuvant chemotherapy (HR, 2.883; P = 0.004) were negative predictors for OS. | china |
Redundancy analysis showed that four environmental factors (total bilirubin, international normalized ratio, prealbumin, and albumin) were significantly correlated with intestinal microorganisms. | china |
Patients with nonmetastatic CRNECs may derive survival benefit from AC. | china |
There were 38.1% (n = 74) benign lesions and 61.9% (n = 120) malignant lesions. | china |
During granulocytic differentiation the decrease of hnRNP A1 reduces inhibition on C/EBPα expression, and the increased C/EBPα promotes the differentiation. | china |
These findings highlight the need for supportive interventions geared toward older adults with MM. | not china |
This study retrospectively investigated pharmacogenetic associations of GSTP1 c.313A > G with chemotherapy-related adverse events in 142 breast cancer patients who received anthracycline and/or paclitaxel chemotherapy. | china |
Based on the present evidence at hand, radiotherapy cannot be considered to be related to the formation of PICC-RVT in cancer patients. | china |
Tumors involved another 9 vessels (11%) that were separated surgically from the tumor and preserved during hepatectomy. | not china |
This cohort included the per study protocol relevant ID population for the primary objective, i.e., T-cell responses by ELISpot in 17 weeks following first vaccination, as well as subjects who discontinued the study before week 17 but showed responses to the treatment. | not china |
This study revealed that the NK cell exhaustion might be induced by upregulation of inhibitory receptors on the surface of NK cells in NK-NPC. | china |
Notably, in TG2-knockdown cancer cells vorinostat anti-proliferative and pro-apoptotic effects were enhanced, whereas in TG2-full-length transfected cells were impaired, suggesting that TG2 could represent a mechanism of intrinsic or acquired resistance to vorinostat. | not china |
Integrins are closely related to the occurrence and development of tumors. | china |
We herein report a case of the pathological diagnosis of GCLS using an endoscopic ultrasound-guided fine-needle biopsy. | not china |
mRNA and protein expression of E-cadherin, α-smooth muscle actin (SMA) and fibronectin(FN) in renal proximal tubule epithelial (HK-2) cells after treatment with TNF-α under different conditions were assessed using western blot and qRT-PCR analysis. | china |
Myocardial carcinoid metastasis is rare with an incidence among metastatic carcinoid patients of 4%. | not china |
The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. | china |
Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53. | china |
Additionally, the Kaplan-Meier plotter database (KM plotter) was used to verify the prognostic function of CENP-A in GC patients. | china |
p53 expression was directly correlated with beclin 1 expression (P=0.044). | china |
Additionally, standardization of formalin fixation and paraffin embedding of surgical samples is required, in order the enable subsequent processing using molecular biology methods. | not china |
We conducted a non-randomized controlled trial to compare the effect of enhanced recovery after surgery (ERAS) versus Routine care on clinical outcomes in elderly patients after colorectal cancer surgery. | china |
It was of interest to develop black barley as a carrier of probiotics and nutraceutical supplement rich in more antioxidants. | china |
This scoping review describes the methods and extent of anticancer drug use at end of life. | not china |
Effect modification was evaluated using a counterfactual framework to estimate confidence intervals and P-values for the natural indirect effects. | not china |
We further identified neutrophil Cathepsin G as the neutrophil component interacting with tumor cell RAGE. | not china |
Estimated median metastasis-free survival (MFS) was 70mo for the total cohort without statistically significant differences between both subgroups (p=0.216). | not china |
Inclusion of the advanced CRC data significantly increased the sensitivity in differentiating superficial neoplasms from deeply invasive early CRC to 65.3% (95% CI, 61.9%-68.8%) with an AUROC curve of .729 (95% CI, .699-.759), similar to experienced endoscopists (.691; 95% CI, .624-.758). | china |
Combing these two predictors, the overall model for predicting EGFR mutation positivity was also constructed, and the AUC was 0.87. | china |
Furthermore, further functional experiments demonstrated that the impacts of E2F7 interference on the proliferation, migration, invasion and apoptosis of SiHa cells were reversed by CISD2 overexpression. | china |
In addition, high-risk ALL patients possessed lower ADAMTS-13 than patients at low risk. | china |
Altered microRNAs (miRNAs) expression has been found in many cancers, including lung cancer, breast cancer, prostate cancer, bladder cancer and colorectal cancer. | not china |
72 HCC patients who had curative resection/liver transplant in 2000-2006 were monitored for recurrence by evaluating the three- or six-monthly AFP and computed tomography images. | not china |
The fluorescence imaging method was employed to monitor the intraperitoneal degradation of PECT hydrogel by labeling PECT with rhodamine B. PECT hydrogel with the dose of 200μL showed about 8days' retention time and most of the injected hydrogel was located in the intestine. | china |
A potentially functional dinucleotide polymorphism, G4C14-to-A4T14, has been identified in the 5' untranslated region of exon 2 of the p73 gene, which may theoretically form a stem-loop structure and affect gene expression. | china |
The modified diagnostic criterion had better diagnostic efficiency because it combined PET and CT imaging data. | china |
Exploration of nanotechnology interventions in anticancer therapy demands further research into the mechanism of intracellular induction of ROS by metal-based NPs. | not china |
The expression and presentation of NKG2D receptor were significantly lower than those in healthy persons, and with an inverse correlation to sMICA and positively correlated with tumor stage. | not china |
We sought to identify a role for therapeutic PI3K inhibition across a range of B-cell lymphomas. | not china |
In contrast, there is a substantial proportion of patients who develop recurrent disease despite aggressive therapy. | not china |
This review discusses current research on exosomes for drug delivery to solid tumors. | not china |
Based on the calculated IC50 , combination treatment with DMC and 5-Fu had an additive antitumor effect in both cell lines. | china |
They were not superior to AFP (0.873) for discrimination of HCC from OMT (0.873, 0.809, and 0.823). | china |
Unfortunately, not all laboratories are equipped to perform this type of test given that specific instruments are necessary as well as specialized personnel. | not china |
Three major themes in each group namely sexually active and sexually inactive evolved on analysis. | not china |
Low C4 and high BAFF levels were associated with NHL on multivariate analysis (P = 0.01 and P = 0.0002, respectively). | not china |
We identified that ADAMDEC1 was upregulated among chemosensitive triple-negative breast cancer (TNBC) tissues in GSE32646, GSE34138, and GSE20271. | china |
In conclusion, our findings demonstrated that circHIPK3 facilitated NPC progression through protecting ELF3 from miR-4288-mediated silencing, which suggested that the circHIPK3-miR-4288-ELF3 regulatory loop might be a potential target for NPC prevention. | china |
The purpose of this study was to derive molecular support for differential post-operative diagnosis, in the form of a simple multigene mRNA-based classifier that would differentiate between FTC and FTA tissue samples. | not china |
We identified 658 patients who received chemoradiotherapy at MD Anderson in 1986-2012; 364 received PCI and 294 did not. | not china |
We also observed an increase in ROS generation during cervical cancer development. | not china |
However, the molecular mehchanism by which DJ-1 induces cancer cell invasion and metastasis remains unclear. | not china |
Disease progression was observed in both patients after primary CAR-T cell infusion but robust re-expansion of prior CAR-T cells and anti-tumor effects was induced by infusion of a secondary CAR-T cells. | china |
These estimates can inform planning of future trials of density-tailored screening and may guide discussion of screening women with dense breasts. | not china |
Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. | not china |
The ΔSUV(max) during and after CRT and the initial ADC values were correlated to the histopathological findings after total mesorectal excision (TME). | not china |
On follow-up, 12 patients had tumor recurrence, 9 of whom died of disease. | not china |
It was further confirmed by the downregulated expression of VM biomarkers and reduced formation of the intersections upon the addition of the signaling pathway inhibitors. | china |
Myocarditis is an uncommon but serious complication of ICIs and may also result from infection with influenza. | not china |
The LNM rates (the number of node-positive patients/the total number of patients) in patients with primary tumours in different lobes (left upper lobe, left lower lobe, right upper lobe, right middle lobe and right lower lobe) were 53.25%, 53.87%, 53.77%, 64.67% and 61.58%, respectively. | china |
This AR activity occurs through a variety of mechanisms, including up-regulation of AR coactivators such as VAV3 and expression of constitutively active AR variants such as the clinically relevant AR-V7. | not china |
Almost all Lynch syndrome tumors have MSI or abnormal IHC and they account for up to one third of all MIN CRCs (3% to 5% of all CRCs). | not china |
It shows self-adaptive size-enlargement upon acidity, thus improving drug retention in tumor to over 120 h. The diameter of agglomerates is increased and drug release is effectively promoted following reduced pH values. | china |
Under the assumption that the atypical tumor may have progressed from the benign tumor, the clonal origin of the lesions was investigated to identify genomic events responsible for the oncogenic process of evolution to higher grades in meningioma. | not china |
The primary outcome was the proportion of overall responders, defined as patients who had at least 3 spontaneous bowel movements (SBMs) per week and an increase of at least 1 SBM from baseline in the same week for at least 6 of the 8 weeks of the treatment period. | china |
Radiation therapy (RT) can enhance immune recognition of "cold" tumors, resulting in a more diversified antitumor T-cell response, yet RT alone rarely results in a systemic antitumor immune response. | not china |
The overall rate of complication related to axilla surgery may be confounded by the type of breast surgery performed. | not china |
Baohuoside-1 is a flavonoid compound isolated from Epimedium koreanum Nakai. | china |
Concurrent endometrial cancer is less frequent with EIN-P than with EIN-E. | not china |
Conversely, increased cell biological behaviors were observed in CAPN2-OV CAKI-2 cells. | china |
Prescribed dose was 64 Gy in 32 fractions for adjuvant and 66 Gy in 33 fractions for salvage IMRT. | not china |
Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10 production. | china |
They were randomly divided into two groups. | china |
MMPs, certainly, are one of the fundamental causes of myeloma bone disease due to their ability to degrade various types of collagens. | china |
The pooled OR was 5.264 (95% CI: 2.928 - 9.464, P < 0.001) and publication bias was not found (P = 0.904). | china |
Thus, we identified the TGF-β-BCL6 and IL-2-BLIMP1 antagonistic pathways in regulation of antitumor CD8+ T cells, which may benefit the development of long-lasting and effective cancer immunotherapy. | china |
Moreover, the anti-cancer functions of Baohuoside-1 was confirmed based on the nude mouse transplantation tumor experiment. | china |
Meanwhile, accumulating cases showed the correlation between tuberculosis (TB) reactivation and anti-PD-1/PD-L1 immunotherapy. | china |
We also hypothesize that some mutations of an X-linked or autosomal gene lead to testicular determination in SRY-negative TH patients. | china |
The protein level of TFF3 and HIF‑1α/VEGFA was determined by western blot. | china |
We found that high levels of p-AKT nuclear expression, observed in 24.3% of the study cohort, were associated with significantly worse progression-free survival and Myc and Bcl-2 overexpression. | china |
A fixed-effect model was established to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). | china |
Moreover, ITGA8 was negatively related to cancer stemness. | china |
Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[18F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. | not china |
This study aimed to assess the potential role of EGOT in the pathogenesis of breast cancer. | china |