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The decrease rate of estimated glomerular filtration rate (eGFR) in RATE group was better than that in RAPN group (P < 0.001). | china |
Stable silencing of TNFAIP8 expression in ESCC-derived cells (Eca109) reduced proliferation, motility, and invasion and induced apoptosis. | china |
We compared glomerular filtration rate (GFR) preoperatively and postoperatively, and renal warm ischemia time between traditional ligature and Hem-o-lok methods. | china |
Enoxacin and entinostat were the most effective adjuvant drug in both long-term in vitro and in vivo adjuvant studies. | not china |
However, the molecular mechanism of metformin in tumor suppression has not been clarified. | china |
Wogonin, a naturally occurring mono-flavonoid, has been reported to have tumor therapeutic potential and good selectivity both in vitro and in vivo. | china |
Moreover, high HuR nuclear expression or aberrant cytoplasmic distribution may serve as a predictor of poor survival. | china |
Increased expression of CALD1 was significantly correlated with histological grade, clinical stage, T stage, and lymphatic metastasis. | china |
Castration-resistant prostate cancer (CRPC) recurs after androgen deprivation therapy (ADT) and is incurable. | not china |
The highly promising preliminary anti-tumor properties of compounds 8 and 11a, were screened at serial dilutions (10(-4)-10(-8) μM) for determination of their GI(50) and TGI against the screened human tumor cell lines. | not china |
Nab-paclitaxel is produced by the combination of paclitaxel particles with human serum albumin. | china |
Additionally, miR-4651 was also associated with HCC prognosis (hazard risk value, 2.67 for overall survival and 3.62 for tumor recurrence analysis). | china |
The methodology presented can be used for any type of sequential information such as any protein and nucleic acid sequence. | not china |
Further testing including external validation of this model is warranted prior to clinical implementation. | not china |
The primary endpoint was progression-free survival (PFS). | china |
Here we are presenting a case of a 58-year-old female with chief complaints of swelling in the left sternal region/breast, and right cervical region. | not china |
In addition, we found significant differences in immune cell infiltration, expression of energy metabolism-related genes, expression of chemokine-related genes, expression of immune checkpoint-related genes, Tumor Immune Dysfunction and Exclusion between the two clusters. | china |
More specific measures should be taken to balance the risk of delayed diagnosis and treatment of NPC and infection of COVID-19. | china |
Quality of life was measured by the Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and the Quality of Life Questionnaire-Breast Cancer Module 23 (QLQ-BR23, simplified Chinese version). | china |
The in vitro stability and in vivo biodistribution of (99m)Tc-TMHEA and (99m)Tc-TMHHA were investigated and compared. | china |
This case report suggested that PD-1 inhibitors might be an effective treatment option for patients with multiple gene-driven PD-L1-expressing NSCLC harboring ALK gene rearrangement. | china |
The endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) sensitivity is low and similar to endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNB) performed with the ProCore 25G or 22G needle. | not china |
Previous reports have shown the L antigen family member 3 (LAGE3) expression in many cancers and has a carcinogenic role. | china |
Overall, our work provides a comprehensive landscape of piRNAs across multiple cancer types and sheds light on their regulatory and functional roles in tumor immunity. | china |
miRNAs have been considered to be playing important roles in malignant behavior. | china |
They have been identified in blood, breast, brain, colon, melanoma, pancreatic, prostate, ovarian, lung cancers and so on. | china |
Therefore, an easy to access screening method of malignant skin tumors is needed urgently. | china |
Artificial intelligence (AI) is increasingly being used in various clinical diagnoses, especially in terms of image classification. | china |
MiR-526b-3p could be targeted by HOXD-AS1. | china |
Median follow-up was 47 months (mo) for SLNRT patients (IQR 40-61), and 33mo for SLND patients (IQR 20-49; p<0.001). | not china |
Further, the viral oncogenes E6 and E7 appeared to modify epithelial function via distinct pathways, thus contributing to cervical cancer progression. | not china |
Additionally, a good clinical outcome after GTR can be expected. | not china |
The diagnostic accuracy of SonoVue in central and lateral compartment LNM was 86.67% and 91.67%, respectively. | china |
The reference lists of relevant studies and systematic reviews were screened to identify additional studies. | not china |
This paper provides new insights into the primary resistance to brigatinib in NSCLC patients carrying ALK G1202R mutation. | china |
The subject of death and dying was most often initiated by patients, and they raised it in various ways. | not china |
Large prospective studies are needed to more accurately define the perioperative factors that influence acute regional toxicity after ILI and to establish strategies to optimise clinical outcome. | not china |
To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. | china |
A meta-analysis of the screened data was performed to investigate the survival status of patients with second primary non-small cell lung cancer (SPNSCLC) after pulmonary lobectomy and partial pulmonary lobectomy, and assess the applicability of such option in the treatment of such disease. | china |
Our case highlights the difficulty in distinguishing CLIPPERS from other steroid-responsive conditions such as neoplastic and granulomatous diseases. | not china |
Because changes in DNA methylation play critical roles in DDCS, we explored the roles that DNA methylation plays in oncogenesis to potentially identify an effective epigenetic treatment. | not china |
Mechanistically, miR-181 is able to directly target LIF and downregulate LIF expression, thereby inhibiting embryo implantation. | china |
These somatic events commandeer many signaling pathways that cooperate to endow aspiring cancer cells with a full range of biological capabilities needed to grow, disseminate and ultimately kill its host. | not china |
Taken together, our data demonstrated that TG2 is involved in the resistance of cancer cells to vorinostat, as well as to other HDACi. | not china |
Breast cancer is one of the most threatening cancers that poses a great risk to women's health. | china |
miRNAs are abnormally expressed in the presence of a pathological status, including cancer. | china |
Besides, ANI increased the survival rate of tumor-bearing mice and suppressed the expression of NLRP3 in a dose-dependent manner. | china |
Additional experimental and human research is required to determine the exact association between OSA and cancer. | china |
In East Asia, D2 dissection has been routine surgical procedure for curable advanced gastric cancer. | not china |
Integration of multi-view data is used to identify cancer subtypes in many computational methods, which obtain different subtypes for the same cancer, even using the same multi-omics data. | china |
Telomerase reverse transcriptase gene (TERT) promoter (TERTp) mutations have been reported as potential predictors of poor prognosis in several cancers, but the prognostic value of TERTp mutations for cutaneous squamous cell carcinoma (cSCC) has not been determined. | not china |
The patient underwent an exploratory laparotomy and a high-grade small bowel obstruction due to the mass was identified. | not china |
In multiple-dose pharmacokinetic study, 12 patients were administered VSLI (1.5 or 1.8 mg·m(-2)) through intravenous infusion weekly for 4 consecutive weeks. | china |
Glioblastoma (GBM) patients face a strongly unfavorable prognosis despite multimodal therapy regimens. | not china |
The ELK1 expression was determined by RT-qPCR and Western blot. | china |
These compounds were evaluated for vitamin D3-agonistic ability and anti-proliferative activity in vitro. | china |
We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N = 97) enrolled in a PDT-ALL-LBL clinical trial. | china |
The other advantages of this system are reversibility and pH-dependent release of Dau from its complex. | not china |
Overexpression of RASSF1A and knockdown of miR-181α-5p could both suppress invasion and migration of OS cells through Wnt pathway. | china |
Natural killer (NK) cells are important effector cells against virus-infected and transformed cells. | not china |
The current retrospective study suggests that pemetrexed combined with oxaliplatin as second-line treatment for advanced NSCLC has comparable safety and response with a pemetrexed alone regimen, but better survival. | china |
Similarly, Cervix cancer (21.9%) was the most common
cancer in females followed by breast (15.48%) and Lung (incl. | not china |
Mechanistically, Knockdown of SNHG12 significantly suppressed the expressions of miR-199a-5p by sponging it, and then increased Klotho expression. | china |
This review focuses on the role of MMP-1, MMP-2, MMP-7, MMP-9, MMP-13, MMP-14, and MMP-15 and the four types of TIMPs in the invasion of myeloma cells, angiogenesis, osteolytic osteopathy, to offer some novel perspectives on the clinical diagnostics and therapeutics of MM. | china |
In a large contemporary series of patients with nodal-only recurrent PC based on PSMA-PET/CT staging, we observed significantly increased PSA PFS in patients undergoing SLNRT while no significant differences could be observed in MFS, and functional outcomes including HRQOL. | not china |
A clinical-radiomic model, which combined clinical and PT-LSLN-IT radiomic signature, showed favorable discrimination and calibration. | china |
Median follow-up was 54 months. | not china |
TLSs were located mainly at the invasive margin of the tumor in cases with esophageal squamous cell carcinoma. | not china |
She was earlier diagnosed of cavitary lung lesion, presumed secondary to tuberculosis and treated with anti-tubercular treatment for 4 months. | not china |
SN+ patients presented an OR = 11.000 (CI95% 2.393-50.589, p = 0.002) for cancer-related mortality. | not china |
Here, we have investigated in colorectal cancer the possible association of UCHL5 tumor expression and patient survival. | not china |
Pseudoalignment methods and RSEM outperform HTSeq and featureCounts for lncRNA quantification at both sample- and gene-level comparison, regardless of RNA-Seq protocol type, choice of aligners, and transcriptome annotation. | not china |
Tumorigenicity assays and blood vessel assessment in athymic mice were used to assess the function of CDK11(p58) in tumor proliferation and angiogenesis. | china |
Comparative expression array analysis of resistant cell lines (SW48, COLO-320DM, and SNU-C1) vs sensitive cell lines (LIM1215, CaCo2, and SW948) was performed. | not china |
Our data provided insights into the influence of pulse sequencing on the observed biological outcomes, and validated the nature of the improved thermal dose localization, alongside significant lowering of the overall energy expenditure entailed in the treatment. | not china |
The AUCs of the GALAD, GALAD-C and GAAP models were excellent for the hepatitis C virus (HCV) subgroup (0.939, 0.958 and 0.954), and for discrimination HCC from HCs (0.988, 0.982, and 0.979), but were relatively lower for the HBV subgroup (0.855, 0.904, and 0.894), and for HCC within Milan Criteria (0.810, 0.841, and 0.840). | china |
Thus, we propose magnetic hyperthermia as adjunctive therapy for fungal keratitis. | not china |
Further, 5-ATAN induced the loss of mitochondrial membrane potential (Δψm) by regulating the Bax/Bcl-2 ratio. | china |
Future studies with a more stringent definition of sarcopenia are required to further confirm our findings. | china |
PDIA3 repression by siRNA could significantly relieve the proliferation- and migration-promoting effect mediated by Dicer depletion in vitro and in vivo. | china |
However, subgroup analysis of four RCT with short-term follow up (≤48 months) did not demonstrate the significant difference in HCC incidence between IFN-treated cirrhotic patients and controls (OR, 0.78; 95% CI, 0.39-1.55; P = 0.48). | china |
© 2016 American Cancer Society. | not china |
The only curative therapy is radical resection. | not china |
Gastric cancer (GC) is one of the most serious gastrointestinal malignancies with high morbidity and mortality. | china |
Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). | china |
Osteosarcoma is the most common primary malignant bone neoplasm and is associated with abysmal prognosis. | china |
To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. | not china |
These multifunctional nanosystems (PCP-Ru/uPA and PCP-Fe/uPA) exhibited remarkable anticancer activity and could overcome the poor stability and low solubility of RuPOP and Fe(PiP)3. | china |
Baseline lower SMI was associated with smaller BMI, smaller PNI, smaller pre-albumin and longer hospitalization days (P<0.05). | china |
Bisulfite sequencing PCR was used for DNA methylation analysis. | china |
This study is the first phase III randomized trial to compare the cycles of neoadjuvant chemotherapy using SOX for resectable locally advanced cancer. | china |
Patients were assigned to either a development or validation cohort. | china |
Here, we show that ZFP91 expression is upregulated in patients with colon cancer. | china |
We retrospectively analyzed tissue samples from a first cohort of 122 patients with head and neck squamous cell carcinoma, including 61 OSCC (cohort #1), and a second cohort of 90 additional OSCC (cohort #2). | not china |
Skeletal metastases are a common problem in breast cancer patients. | china |
In 2021, Chinese regulatory agencies issued the new guideline for clinical research and development of antitumor drugs, triggering a series of responses on the drug market. | china |
Addressing the issues identified will facilitate cancer nurses' provision of survivorship care and help address haematological survivors' needs with regard to the physical and psychosocial consequences of their cancer and treatment. | not china |
PIWI-interacting RNAs (piRNAs), an emergent type of non-coding RNAs during oncogenesis, play critical roles in regulating tumor microenvironment. | china |
Patients with high amphiregulin and low heregulin had significantly higher objective response rate at 58% and significantly longer progression-free survival of 216 days. | not china |
We therefore developed a novel mouse model that enables unprecedented levels of chromosome missegregation in the adult animal. | not china |