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Overall these results suggest that xanthohumol acts as a KRT18 regulator to suppress the growth of ESCC. | china |
It dose-dependently inhibited STAT1/3 protein phosphorylation and moderately inhibited NF-κB (p50), NF-κB (p52), and NF-κB (p65) protein expression in both dose- and time-dependent manner. | not china |
The peaks of CAR T-cells in the DSI group were higher than those in the DLI group. | china |
This study aimed to investigate the effects of Cholestin extract on the expression of matrix metalloproteinase (MMP)-2 and MMP-9 by tumor necrosis factor (TNF)-α-treated human aortic smooth muscle cells (HASMCs). | not china |
Peripheral blood immune checkpoint test using flow cytometry indicated that the PD-1 + CD8 levels were positive. | china |
Collectively, the vast majority of variants in TCR-related genes could be classified as gain-of-function. | not china |
Plasmid-mediated expression of VEGF-C-shRNA was employed to silence VEGF-C gene expression in human SGC-7901 cell lines. | china |
The DCE-MRI data were analyzed using the adiabiatic approximation to the tissue homogeneity (AATH) model to assess the change of tumor vascularity in response to the treatment. | not china |
A total of 64 case-series studies were included, corresponding to a cohort of 5585 patients. | not china |
Delays in diagnostic testing after a positive result from a screening test can undermine the benefits of colorectal cancer (CRC) screening, but there are few empirical data on the effects of such delays. | not china |
Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. | not china |
We applied gene expression profiling to better understand the molecular mechanisms associated with responsiveness to these drugs. | not china |
All other extracts were nontoxic. | not china |
Accumulating evidence has suggested that carcinoma cells can enter a resistant state via induction of the EMT. | china |
Fertility-sparing surgery is feasible for young patients with early stage. | china |
Colony formation and wound healing assay were conducted to access the effects of atractylodin on cell proliferation and directional migration activity of CL-6 cells. | not china |
Patients in the pm-Pac-plus-cisplatin group showed significant improvements in IRC-assessed ORR compared with those in the sb-Pac-plus-cisplatin group (50% versus 26%; rate ratio 1.91; P < 0.0001). | china |
Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. | not china |
A comparison of proteomic profiles between responders and non-responders has identified 18 differentially expressed proteins. | not china |
In parallel, expression of the proliferation marker PCNA was decreased, proapoptotic caspase 3, 7, and 9 levels were increased, and expression of the anti-apoptotic protein survivin was reduced. | china |
The high-nickel/high-miR-21 subgroup had shorter OS and RFS periods when compared to the low-nickel/low-miR-21 subgroup. | not china |
Among the 273 UTUC patients (median age, 68 years) enrolled in our study, 102 had a BMI > 24.0, 100 suffered from diabetes, and 120 had hypertension. | china |
AITC increased p53, p53pSer15 , and p21 but decreased murine double minute 2 (MDM2)pSer166 and O6 -methylguanine-DNA methyltransferase (MGMT) in AGS cells; however, it has a similar effect of AITC except increased ataxia telangiectasia and Rad3 -related protein (ATR)pSer428 , checkpoint kinase 1 (CHK1), and checkpoint kinase 2 (CHK2) in SNU-1 cells. | not china |
Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown. | china |
Groundwater contaminant fate/transport and distribution system models provided monthly estimated residential contaminant levels. | not china |
She was managed with breast conservation surgery and axillary dissection for invasive ductal carcinoma, no special type, Nottingham grade 2 (21 mm). | not china |
Advanced central lung cancers can invade the superior vena cava (SVC). | not china |
Mechanistically, MYC presets gastrointestinal cancer sensitivity to RTX through upregulating TYMS transcription, supported by TCGA data showing that complete response cases to TYMS inhibitors had significantly higher MYC and TYMS mRNA levels than those of progressive diseases. | china |
No statistically significant differences were observed between axi-cel and tisa-cel in terms of ORR, DoR, and OS (p > 0.05). | not china |
On unenhanced CT, tumour attenuation was greater than in normal renal parenchyma (85.7 %). | china |
The cumulative incidence of thromboembolism was increased both for patients with hypo- (20.0%) and hypercholesterolemia (16.7%) compared to patients with normal TC levels (2.2%) at diagnosis (P = 0.0074). | not china |
The lack of effective therapies for bone metastatic prostate cancer (PCa) underscores the need for accurate models of the disease to enable the discovery of new therapeutic targets and to test drug sensitivities of individual tumors. | not china |
Eighteen of 20 patients with HSIL/cervical intraepithelial neoplasia 2 (CIN2) (90%) and high-risk mHPV persisted on HSIL+/CIN2 + whereas 6 of 11 patients with sHPV infection did not demonstrate HSIL+/CIN2 + on follow-up (54.5%) (P = .066). | not china |
PSA and ostase levels rose to 1245 µg/l and 434 U/l, respectively, and MRT revealed progressive skeletal metastases, indicating that the tumor acquired resistance. | not china |
The MRI-PMbdex was created from 2432 men with suspected PCa; this cohort comprised the development and external validation cohorts of the Barcelona MRI predictive model. | not china |
Strong cytoplasmic KDM4B expression in the reactive cellular infiltrate and also in Reed-Sternberg (RS) cells predicted poor relapse-free survival (RFS) (p=0.020 and p=0.022, respectively) in patients with limited-stage disease. | not china |
Distinction between infectious and noninfectious cloudy dialysate and the potential of changes in the peritoneal membrane transport mechanisms are issues that should concern the care of PD patients with cloudy dialysate containing malignant cells. | not china |
Our study suggests an OS condition in a cohort of treatment-naïve ET patients, not associated with JAK2 mutational status or with chronic inflammation situation. | not china |
The conditional overexpression of twist1a and xmrk was shown to promote liver tumor metastasis in zebrafish, resulting in increased apoptosis and cell proliferation as well as tumor maintenance and propagation independent of the inherent EMT-inducing activity of xmrk. | not china |
CD157-targeting antibodies enhanced survival, decreased apoptosis and reduced AraC toxicity in AML blasts and cell lines. | not china |
Our study found a relatively low cut-off point for detection of recurrence (5.54 μg/L). | not china |
In vitro, miR-146a overexpression in NKTL cell lines, SNK6 and YT, inhibited nuclear factor κB (NFκB) activity, suppressed cell proliferation, induced apoptosis, and enhanced chemosensitivity. | not china |
The stability of these weights were evaluated performing 10,000 bootstrap resamplings. | not china |
The rate of endocrine insufficiency after enucleation seemed lower (Nil vs. 4.5%, P = 0.55). | china |
This report indicates that cutaneous lymphoid neoplasms should be considered a possible side effect among patients receiving Fingolimod. | not china |
There were no significant differences in the 4β-OHC/C ratio between men and women in end-of-life patients (p < 0.25). | not china |
We also generated an EPI-resistant liver cancer cell line (MHCC-LM3er cells), and found that UTI could sensitize the LM3er cells to EPI. | china |
Intra-scan CVs for these sets were comparable to that for ADCIVIM. | not china |
This meta-analysis aimed to determine whether IFN therapy reduced the incidence of HCC in HCV-related cirrhotic patients. | china |
In 2022, two trials, PEACE-1 and ARASENS, demonstrated the potential of triplet therapy, adding an ARPI to an ADT-docetaxel doublet. | not china |
Therefore, unfavourable pathological features (pT3-4/N+ and/or Gleason score >6) were present in 40 (30.5%) patients. | not china |
In the multivariate analysis of the training test, both α-SMA and CD163 were independent prognostic factors for overall survival and progression-free survival (all p<0.05). | china |
Overall and infectious complications were noted in 37 (27.8%) and 16 (12.0%) patients. | not china |
When only preoperative factors were considered in multivariate analysis, primary tumor size and serum AFP levels over 400 ng/mL were identified as significant predictors with adjusted hazard ratios of 1.24 (95 % CI 1.07-1.45) and 1.72 (95 % CI 1.05-2.82), respectively. | not china |
We conducted a pilot trial evaluating PD-1 immune checkpoint inhibitor therapy in combination with DNMT and HDAC inhibitors in MMRp CRC. | not china |
Advances in early detection and treatment of breast cancer (BrCA) have led to better survival. | not china |
However, the interaction and its related function between HPV16 E7 and Daxx have not been adequately investigated. | china |
In addition, RBM4-oe suppressed the migration and invasion of cells by EMT. | china |
Measurements were performed on a MAGNETOM-Terra 7 T MR-scanner in clinical mode using a Nova 1Tx32Rx head coil and on a 3 T MAGNETOM-Prisma scanner with a standard 32-channel head coil. | not china |
Over 70% of CRC cases are sporadic and related to lifestyle. | not china |
The algorithm modification with the best performance was chosen as the final version of the algorithm. | not china |
The relapses after surgery are frequent and chemotherapy may be palliative. | not china |
To gain a better insight into the signal transduction mechanisms of PDGFRα oncogenes, we mutated twelve potentially phosphorylated tyrosine residues of FIP1L1-PDGFRα and identified three mutations that affected cell proliferation. | not china |
Adjudicated medical record review captured prevalent and incident comorbidities during follow-up or until death as collected from the National Death Index. | not china |
Multivariate Cox regression analyses further confirmed that plasma EVL levels were independent predictors of PACA patient prognosis. | china |
CD4+ naïve T cells infiltration was a favorable prognostic factor for RFS, however, there was no effect of CD4+ T cells infiltration on RFS in patients with high APE1 expression. | china |
In both cohorts, 50.5% scored above threshold for anxiety, depression, or both. | not china |
In summary, these results suggest that CAP induces cytotoxicity by disturbing mitochondrial potential, and inhibits ATP synthesis in NET cells. | not china |
In most consultations, direct talk about death was initiated only once. | not china |
Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. | china |
We transfected miR-371 or its inhibitor in two human HCC cell lines, then used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation, and transwell migration assays to evaluate the effects on cell proliferation, migration, and invasion. | china |
To analyze the importance of unique cytoarchitectural patterns and the immunohistochemical profile in the diagnosis of myoepithelial carcinomas. | not china |
Besides, ablation experiments showed that fusing transformer into our modified nnUnet framework improves the performance of brain tumor segmentation, especially for the TC region. | china |
It has also been shown to promote epithelial-to-mesenchymal transition (EMT), invasion, and metastasis; however, there is currently no in vivo evidence that Twist1 plays a role in the metastasis of liver tumors. | not china |
Phosphorylation of Akt was studied using Western blot analysis. | not china |
The health utility value of progression-free survival, the price of toripalimab, and the cost of best supportive care were factors that significantly influenced the ICER, but no change in any of them could change the model result. | china |
Preclinical data showing that SRC and SRC-family kinases (SFKs) mediate intracellular signaling pathways controlling key biologic/oncogenic processes provide a strong rationale for investigating SRC/SFK inhibitors, e.g., dasatinib, in GBM and clinical studies are underway. | not china |
One hundred and eight men undergoing staging mpMRI before radical prostatectomy (RP) were retrospectively evaluated. | not china |
Eighty-two well-characterized, high-risk hereditary breast and/or ovarian cancer (HBOC) BRCA1/2-founder mutation-negative Finnish individuals, were screened for germline alterations in seven breast cancer susceptibility genes, BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1. | not china |
The purpose of this retrospective study is to perform the incidence
of all cancers both in males and females over the ten years in Nepal. | not china |
There were two grade 3 treatment-related adverse events. | not china |
The best quantitative structure-disease relationship model is based on eleven Shannon entropy indices. | not china |
Eighty-four patients were included, 45 (53.6%) men with a mean age of 57.3 years. | not china |
This study assessed the association between body composition and prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) patients treated by radical nephroureterectomy. | china |
The incidence of treatment-related serious adverse events (9% versus 18%; P = 0.0090) was significantly lower in the pm-Pac-plus-cisplatin group than in the sb-Pac-plus-cisplatin group. | china |
We detected no statistically significant difference in oxidative stress and DNA damage by the duration between last administration of chemotherapy and death. | not china |
Elucidating the underlying molecular mechanism that modulates HCC progression is critical for exploring novel therapeutic strategies. | china |
Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis. | not china |
Both treatment arms received the same chemotherapy regimen. | china |
This may suggest that the interval to relapse in the bladder after nephrectomy may be a more important prognostic factor than the presence of synchronous metastases in other organs. | not china |
Multivariate analysis results revealed that miR-215 downexpression was an unfavorable prognostic factor for DSS in addition to tumor size, ER, and lymph node metastasis. | china |
O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. | china |
The Cancer Genome Atlas (TCGA) unpaired thyroid cancer and normal RNA-seq data were downloaded, and our paired thyroid cancer and normal samples were analysed by a polymerase chain reaction. | china |
In this uncommon disease: hyperparathyroidism-jaw tumor (HPT-JT) syndrome, parathyroid tumor is frequently malignant and usually associated with nonendocrine malignancies (2). | not china |
Pancreatic cancer stem cells (PCSCs) are assumed to contribute to the initiation and invasion of PDAC. | not china |
ATG5 knockdown using ATG5 siRNA partially suppressed the LC3B-II expression, decreased the LC3B-I/II conversion rate and enhanced the P62 expression. | china |
Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. | china |
miR-522 might be a valuable target for HCC therapy. | china |
The clinicopathological information of 115 consecutive CRC patients were collected. | china |
Tertiary lymphoid structures (TLSs) have been reported to be involved in immune responses in many carcinomas. | not china |