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Finally, the levels of c-Fos, ERK1/2 and p-ERK1/2 were determined by western blot. | china |
Here we report a case of a lung adenocarcinoma acting as the recipient of papillary thyroid carcinoma, with multiple spreading foci of the two cancers in the lung simultaneously. | china |
Systematic review and meta-analysis. | china |
The new nomogram is a promising tool in further choosing the candidates for intracranial surgery among NSCLC with BM and in helping physicians tailor suitable treatment options before operation in clinical practice. | china |
The STK1 levels of 37 patients were determined by enhanced chemiluminescent dot-blot assay on the day before chemotherapy, and on day 1 and day 28 after start of the treatment. | china |
These findings suggest that CD1d-phenyl glycolipid complexes may interact with the same population of iNKT cells but with higher avidity and stability to drive Th1 polarization. | not china |
A cluster of five signals differentiate malignant tumors from benign renal masses and healthy subjects. | not china |
A hazard ratio (HR) with 95 % CI was used to assess the impact of E-cadherin gene methylation on overall survival (OS) of LC patients. | china |
RESULTS The median OS for the entire group was 24 months, while the 1-, 2-, and 3-year OS rates were 78.5%, 49.4%, and 26.8%, respectively. | china |
Effective treatment outcome has been observed after administration with afatinib. | china |
The aim of the first layer is releasing the drug within 4 weeks, obtaining a prolonged and modified release. | not china |
Notably, the 660 nm laser-triggered photodynamic reaction of Ce6 optimizes the delivery of Ce6-C18-PEG/125I-Cur at various stages, including tumor accumulation, cellular uptake, and lysosome escape, causing plenty of 125I-Cur to enter the nucleus. | china |
We analyzed the expression level of CRKL in 305 cervical cancer tissue samples available in TCGA database, and then selected two groups of cancer samples with CRKL differentially expressed to analyzed potential CRKL-regulated alternative splicing events (ASEs). | china |
The isocitrate dehydrogenase activity of the Y208C mutant was attenuated compared with that of wild-type (WT) cIDH1, but the attenuation of Y208C was less intense than that of the R132H mutation. | not china |
KIAA1199 expression directly influences the expression of EMT markers. | china |
Patients with high baseline plasma Epstein-Barr virus DNA copy number (>104 cps/mL) show worse PFS. | china |
However, limited research has been conducted on the survival and treatment pattern in distant lymphatic metastatic cervical cancer. | china |
Advances in molecular technologies have led to the discovery of many disease-related genetic mutations as well as elucidation of aberrant gene and protein expression patterns in several human diseases, including cancer. | not china |
This was a prospective study performed after HIPEC for peritoneal mesothelioma between 2002 and 2015. | not china |
The SYS+TAR biopsy detected significantly more cancer than SYS and TAR only biopsies (72.9% vs. 56.9% and 53.8% respectively; p=0.03). | not china |
Therefore, it is a research topic with practical significance. | china |
Blockade of Ca(++)-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) inhibits the proliferation of human glioblastoma by inhibiting Akt phosphorylation, which is independent of the phosphatidylinositol 3-kinase pathway. | not china |
Similarly, a significant correlation was found between Per2 and Per3 (P=0.045). | china |
This study aimed to explore various factors that are highly related to local recurrence and to develop a new prediction model for local recurrence after curative resection. | not china |
SLOW-EPSI at 7 T showed the highest accuracy for IDH-status prediction (91.7% accuracy, 11 of the 12 predictions correct with 1 false negative case). | not china |
Cytokine antibody arrays and further functional investigations showed that matrix metalloproteinase-8 (MMP-8) partly mediates the promotion effects of SR on the migration and invasion ability of HCC cells by regulating AMPK/mTOR signaling. | china |
Also, the model envisages anticipating the survivability of a patient on the basis of treatment and follow-up details. | not china |
Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P < 0.05, TC and Lp(a); P < 0.01, FBS, TG, LDL-C, apoB); and lower HDL-C and apoAI (P < 0.05). | china |
Future research should carefully consider biological mechanisms to guide more nuanced selection of endpoints and interventions, including product, dose and administration. | not china |
Overall, 353 BC patients and 360 cancer-free controls were enrolled. | china |
A significant increase in the number of cariogenic bacteria in the saliva during episodes of chemotherapy-induced neutropenia suggests that the activity of dental caries increases in children undergoing antineoplastic treatment. | not china |
The median progression free survival (PFS) and overall survival (OS) were 10y and 11.3y, respectively. | not china |
The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is nothing less than a death sentence, with few treatment options for palliation or prolonging life. | not china |
Higher concentrations of 25OHD3 were longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors. | not china |
The activity of CISD2 was detected using luciferase report assay and chromatin immunoprecipitation (ChIP) assay was used to confirm the binding of E2F7 and CISD2 promoter. | china |
The cell cycle arrest and reactive oxygen species (ROS) accumulation were determined by flow cytometric analysis. | not china |
© 2015 Wiley Periodicals, Inc. Head Neck 38: E1713-E1721, 2016. | not china |
Mitochondrial isocitrate dehydrogenase 2 (IDH2) is an important metabolic enzyme in the tricarboxylic acid cycle (TCA) cycle. | china |
Furthermore, a differential sensitivity to docetaxel, a chemotherapeutic drug, was observed as compared to a traditional PCa cell line. | not china |
In the current study, we identified CCAT2 as a relevant lncRNA and investigated its role in the progression of ESCC. | china |
For cytotoxic studies (MTT assay), Molt-4 (target) and U266 (B lymphocyte human myeloma, non-target) cells were treated with Dau, Dau-aptamer-SWNTs tertiary complex. | not china |
Therefore, improving the chemotherapy sensitivity of colorectal cancer cells is of great significance for improving the prognosis of patients with colon cancer. | china |
In total, 22 B-ALL patients who relapsed after allo-HSCT received anti-CD19-CAR T-cell therapy. | china |
In the diagnosis of pulmonary nodules, artificial intelligence (AI) assisted diagnosis technology has been rapidly developed, so testing its effectiveness is conducive to promoting its important role in clinical practice. | china |
And the postoperative levels of Breg cells and IL-10 were significantly lower than the preoperative levels (P < 0.05). | china |
Furthermore, we assessed the antioxidant activity of the methanolic extract by DPPH assay and oxygen radical absorbance capacity assay, which yielded IC50 values of 414.30 µg/mL and 170.03 ± 44.40 µM TE/equivalent, respectively. | not china |
Mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) are found in a subset of gliomas. | not china |
The mRNA levels of sphingolipid-related and other cancer-related factors were measured in human hepatocellular carcinoma (HCC), colorectal cancer, and esophageal cancer patients' tumours and in their adjacent non-tumour tissues. | not china |
Apoptosis was identified by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. | china |
The gene quantification analysis was measured through real-time polymerase chain reaction. | not china |
Cell proliferation and apoptosis were also evaluated by MTT assay and flow cytometry (FCM). | china |
Among patients who underwent esophagectomy, 13 (33.3%) had LNM, and the mortality rate was 50.0% and 11.1% for those with and without LNM, respectively (P < .01). | not china |
Finally, lack of LASP1 sensitizes 231S cells to pharmacological inhibition of eIF4A by Rocaglamide A as evident through BIRC5 expression. | not china |
There was no significant difference in PSMA expression between DAC/IDC-P and adjacent PAC (78.6 vs 93.4, p = 0.166). | china |
Our work suggests apoptotic materials, abundant in tumors, also contribute to AKT activation by stimulating MERTK that in turn phosphorylates Y26 in the AKT PH domain. | not china |
The present study indicates that CAPN2 may act as a prominent indicator for RCC progression and a novel therapeutic target for RCC patients. | china |
Finally, the displaced integral primers again hybridized with the MBs and initiated cycle amplification. | china |
IL-17A and TNF-β are directly related to the ED in newly APL, especially IL-17A, which also affects ICH in these patients. | china |
Trial results were limited by small sample size attributed to difficulties in recruiting terminally ill patients. | not china |
Proper treatments can reverse intraoperative cardiac arrest. | china |
The unique characteristics included the spotted enhancement (mottled high density) in schwannoma (P < 0.0001), adipose tissue in liposarcoma (P < 0.0001) and paravertebral location in neurogenic tumors (P < 0.0001). | china |
One of the main reasons for this problem is the changes in the regulation of genes that have a key role in the epithelial-mesenchymal transition (EMT). | not china |
There was a negative correlation between lnc-LUCAT1 and miR-7-5p. | china |
Advances in endoscopic imaging and therapy have shifted the paradigm of managing early esophageal cancers. | not china |
In the present study, we evaluated ANRIL expression in epithelial ovarian cancer (EOC) and defined its clinical implications and biological functions. | china |
The clinical outcome of this small cohort of nine patients supported the efficacy of this regimen: two patients achieved rapid complete remission after three-cycle treatment, and six patients remained stable, subsequently became sensitive to conventional therapy, and also achieved complete remission. | china |
BCR-free survival was significantly lower in patients with high Cdc20 expression than those with low Cdc20 expression (P= 0.018). | china |
Currently, phone counselling is available across Canada for individuals referred by healthcare workers and by self-referral. | not china |
In patients with PTC-DTF there is a risk of recurrence of the benign component of the tumor. | not china |
Conversely, the functional assays showed that ZC3HAV1 knockdown significantly reduced tumorigenesis. | china |
Methylene blue (MB) alone or combined with 99mtechnetium-labeled sulphur colloid (Tc99m) or indocyanine green (ICG) is widely used for sentinel lymph node biopsy (SLNB) of early-stage breast cancer in developing countries and regions. | china |
X-tiles and decision trees were used to determine the optimal cutoff for the number of lymph nodes based on the survival outcomes of patients with RCC. | china |
Focusing on mortality and case burden outcomes defines public health oncology or population-affecting cancer medicine. | not china |
All checkpoint inhibitors received a priority review status and access to at least two additional FDA special access programs, more often breakthrough therapy designation and accelerated approval. | not china |
The data were analyzed by three commonly used software programs: geNorm, NormFinder, and BestKeeper. | china |
With the improvement of cancer-directed therapies, some of these patients can receive curative treatment. | china |
The funnel plot of each parameter was symmetrical with the lower part broader than the upper. | china |
Regarding the mechanism, we conducted a RNA pulldown with a biotin-labeled circRHOT1-specific probe and found that circRHOT1 recruited TIP60 to the NR2F6 promoter and initiated NR2F6 transcription. | china |
Binary logistic regression showed that CTRP4 was associated with CAD and even the amount of coronary artery lesions (P < 0.05). | china |
The most common toxicity was grade 1-2 leukopenia, reported in 32% of cases. | not china |
The survival time was followed up to 102 d. The mice in the Rg3 + CTX group showed significant increased survival time compared with those in the control group (P < 0.05). | china |
Herein, we aimed to identify the most appropriate IO-based therapy for metastatic renal cell carcinoma applying an alternative method to overcome the issue of hazard assumption violation for meta-analyses. | not china |
Conversely, the discontinuous pattern displayed an incomplete network around tumor nests. | not china |
Two patients presented with anterior uveitis, two with panuveitis and one with posterior uveitis. | not china |
These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-κB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-κB levels. | not china |
The migration activity of SGC-7901 cells was attenuated in vitro (P<0.05). | china |
A total of 9 RCTs involving 666 patients with breast cancer were included. | china |
For the trainees with rich experience in open distal gastrectomy, the learning curve is considered to be completed after 20 MLADG cases. | china |
This work provides a technical roadmap for studying the bronchus and cytoarchitectural structure and their spatial relationship in LA tissue, which may help with the understanding of the main histological structure of LA among pathologists. | china |
4-nitroquinoline 1-oxide (4-NQO) and arecoline were used to induce oral cancer in mice, and the main factors for gene expression influencing carcinogenesis were identified through single-cell RNA sequencing analysis. | not china |
We thereby inverted the effects of tumor-derived IL4 so that the proliferation and activation of tumor directed cytotoxic T cells was enhanced rather than inhibited in the tumor microenvironment, resulting in superior antitumor activity. | not china |
The history of clinical research, drug development, and the regulations has come of age, and as a result clinical oncology research has a more defined scope and purpose. | not china |
The data analyses indeed suggest that cancers arise via dysregulated "Ig-like SHM responses" involving rogue DNA and RNA deaminations coupled to genome-wide RT events. | not china |
Subgroup analyses regarding gender, pathologic subtypes and smoking status were also executed. | china |
To evaluate the feasibility of quantitative contrast-enhanced ultrasonography (CEUS) for predicting and assessing cervical tumor response to neoadjuvant chemotherapy (NACT). | china |
The overall survival of the chemotherapy-based treatment group was significantly higher than that of the immunotherapy-based group. | china |
In conclusion, our study indicates that technetium-99m labeled methotrexate is a potentially strong tumor diagnostic agent with low uptake in normal tissues. | not china |
Conversely, overexpression of Twist1 led to increased radioresistance of SiHa cells, which in turn increased nuclear EGFR localization and expression levels of nuclear DNA-PK. | china |
Rise in cancer mortality rate has been an issue for a long time with female breast cancer as one of the most detected cancers. | not china |
Tetrandrine can probably be combined with radiotherapy or other chemotherapeutic agents to treat gliomas. | not china |