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Compared with adjacent stomach tissues, gastric adenocarcinoma tissues showed significantly higher SLC39A1 on both mRNA and protein levels. | china |
Little data exist to guide treatment when this tumor extends to involve the structure of cavernous sinus. | china |
Population-based data on the risk of cardiac death among cancer survivors are needed. | not china |
Here, we comprehensively profiled IgE type kappa MM on a genomic and immune repertoire level by integrating DNA- and single-cell RNA sequencing and comparative profiling against non-IgE type MM samples. | not china |
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis caused by the expression of CD68-positive and CD1a-negative foam tissue cells, which is polar in pediatric patients. | china |
Of 164 patients assigned to receive neoadjuvant chemotherapy in the JCOG9907 trial, multivariate analyses were performed for 159 and 149 patients to evaluate the preoperative and the combined preoperative and postoperative prognostic factors, respectively. | not china |
Our results show that the initial detrimental effects of random missegregation are outbalanced by clonal selection, which is dictated by the chromosomal location and nature of certain genes and is sufficient to drive cancer with high prevalence. | not china |
In short, our study significantly enhances the effectiveness of transdermal drug delivery by constructing BPMNs and provides a promising novel strategy for transdermal cancer treatment with multiple therapies. | china |
We also show that BRAF-MEKi but not CDK4/6i enhanced MHC Class I expression in melanoma cell lines in vitro. | not china |
According to multivariate analysis, age and log odds of positive lymph nodes are independent risk factors for overall survival (hazard ratio = 2.660, 95% confidence interval 2.114-3.346, P < 0.001). | china |
There are different types of clinical research, including behavioral, therapeutic, and nontherapeutic studies, where clinical research nurses must understand the treatments and the drug development process to better serve their patients. | not china |
This study included 183 patients from four centers in southwest China who underwent radical section of Stage III-N2 NSCLC without any preoperative therapy. | china |
Despite promising clinical outcomes, intrinsic or acquired resistance to CDK4/6 inhibitors has limited the success of these treatments; therefore, the development of various strategies to overcome this resistance is of great importance. | not china |
Five RTs reported suffering from at least one physical assault. | not china |
In cell cultures, USP22 overexpression increased CCA cell proliferation and mobility, and induced epithelial-to-mesenchymal transition (EMT). | china |
Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups. | china |
Undifferentiated gastric cancer is also expected to become an absolute indication in the future. | not china |
Taken together, these results indicated that PD-1 expression defines two sub-populations with distinct functions that differentially impact patient outcome in FL. | not china |
In vitro experiments were conducted to characterize baseline growth and migration and response to radiation and temozolomide. | not china |
We also show that miR-181 expression is regulated by the transcriptional factor Emx2, and the Emx2-miR-181 axis plays an important role in regulating embryo implantation. | china |
High pretreatment interleukin (IL)-6 was associated with both worse PFS and OS in the whole population (IL-6 >13.80 pg/mL), in patients receiving ICIs only (IL-6 >11.30 pg/mL), and in patients receiving chemoimmunotherapy (IL-6 >11.85 pg/mL). | china |
Previous trials reported inconsistent findings regarding the efficacy of gefitinib on overall survival (OS) and progression free survival (PFS). | china |
Overall survival of patients with BMs from CRC improved since 2014, which can be attributed to advances in chemotherapy and the more widespread use of stereotactic radiotherapy. | not china |
Atopic dermatitis (AD) is a chronic recurrent dermatitis with profound itching, which could be the first manifestation of acute myeloid leukemia (AML). | china |
In pre-planned observational analysis of the POWER-remote trial, we examined the impact of weight loss on patient-reported outcomes (PROs). | not china |
This comprehensive description of publications on anticancer drug use at end of life underscores the importance of methodological factors when designing studies and comparing outcomes. | not china |
Massive ascites (P=0.017) and peritoneal solid nodules (P<0.001) were more common in high-grade cases. | china |
TIMPs, as important regulators of MMP hydrolysis or activation, also participate in the occurrence and evolution of MM and the formation of bone disease. | china |
Herein, we uncovered that TRAF5 level was reduced in LUAD tissues. | china |
Total intracellular adenosine triphosphate (ATP) is mainly generated by glycolysis and mitochondrial oxidative phosphorylation. | not china |
ALK inhibitors including crizotinib, ceritinib and alectinib revealed significantly better PFS (HR 0.42 [0.35, 0.50; p < 0.00001]), ORR (Overall OR 6.59 [4.86, 8.94; p < 0.00001] as compared to chemotherapy in the first line as well as second line treatment settings. | china |
Essentials Venous thromboembolism (VTE) prevention strategies require effective risk assessment models. | not china |
Recurrence in an SLNB negative nodal basin result occurred in 10 patients (false negative rate of 19.2%). | not china |
The area under the curve (AUC) of mSEPT9 was 0.850, which was slightly higher than that of CEA (0.842). | china |
IL-17A is confirmed to be an independent risk factor for ED and ICH of newly APL. | china |
The sparsity, heterogeneous diversity, and fast-growing scale of scRNA-seq data pose challenges to the flexibility, accuracy, and computing efficiency of the differential expression (DE) methods. | china |
This study investigated whether exercise could regulate the occurrence and development of HCC through mitosis. | china |
We assessed the magnetic resonance imaging (MRI) findings of lateral pelvic lymph node (LPLN) metastasis in patients with advanced low-rectal cancer treated with preoperative chemoradiotherapy (CRT) and LPLN dissection (LPLD) for clinically suspected LPLN metastasis. | not china |
That, a small subpopulation of cancer cells known as "cancer stem cells" (CSCs) are shown to be responsible for deriving clonal heterogeneity/diversity in tumors, which render them resistant to conventional treatment regimes. | not china |
Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF and the promoter activity of VEGF. | china |
Disrupting proteostasis in cancer cells by targeting UPRmt constitutes a novel anticancer therapeutic strategy. | china |
We suspected non-bacterial cystitis as an immune-related adverse event caused by nivolumab and were able to treat it by administering prednisolone. | not china |
Immunoblotting was performed to detect the expression of several proliferation and apoptosis-related proteins. | china |
The median survival of patients with hMSH2 methylation was shorter than that of patients without hMSH2 methylation (log-rank test, P=0.0035). | china |
However, the expression pattern and roles of lncRNAs in the development of PDAC remain unknown. | china |
The ratio of correct answers to the total number of points possible to obtain was evaluated according to the adopted criteria (≤25%—very low level of knowledge; >75%—high level of knowledge). | not china |
This study was performed to analyze the application of dexmedetomidine (Dex) in anesthesia for gastric cancer surgery and its effect on serum inflammatory factors in patients. | china |
DPS is a robust proteomic approach to identify potentially novel viral sequences in infectious tumors when nucleic acid-based methods are not feasible. | not china |
An operation was arranged because bleeding from the tumor was suspected as a cause of anemia and because surgical resection was considered to be desirable for accurate diagnosis. | not china |
A literature search identified 28 reported cases of EBV-SMT in addition to our own experience with one case. | not china |
In addition, we proved that SUMOylated TUFT1 is not only an upstream signal for AKT activation but also directly activates mTOR by forming a complex with Rab GTPase activating protein 1, which further inhibits Rab GTPases and promotes the perinuclear accumulation of mTORC1. | china |
It is the first report illustrating that CEMIP might be one of the metastatic triggers in SCLC. | china |
The presence of either tumor cells or IF individually increased macrophage migration directedness and speed. | not china |
This meta-analysis revealed that E-cadherin gene promoter methylation was associated with an increased risk of LC, especially in Asian population, and methylated E-cadherin predicted long survival in patients with LC. | china |
Moreover, IKKε enhanced the growth of MDA-MB-231 and MDA-MB-436 cells. | china |
To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. | not china |
Health care providers who care for cancer patients should be aware of these risks. | not china |
Several genes including FANCC and UGT2A1 revealed different magnitude and direction of expression changes between the two groups (two-sided Student's t-test, P < .05). | not china |
Besides, down-regulated genes were also enriched in primary immunodeficiency pathway. | china |
Providers support a reflex-testing program to improve the identification and management of suspected LS patients. | not china |
We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. | not china |
CAPN2 exhibited a significant overexpression in human RCC tissues and cell lines compared with adjacent non-tumor tissues and normal human proximal tubule epithelial cell line HK-2. | china |
The hazard ratio (HR) or odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the relationship between USP22 expression and clinicopathological and prognostic value of GC patients. | china |
Case study. | not china |
Cell motility and migration were assessed using wound healing and transwell assays. | china |
Plasma apoCIII, TNF-α and hs-CRP levels were higher in CHD individuals (16.77 ± 5.98 mg/dL vs. 10.91 ± 4.97 mg/dL; 17.23 ± 6.34 pg/mL vs. 9.49 ± 3.88 pg/mL; 9.55 ± 7.32 mg/L vs. 2.14 ± 1.56 mg/L; P < 0.01 vs. healthy participants). | china |
These results suggested that the CpG site methylation appears to be an informative prognostic biomarker in HCC. | china |
We report a case of a 38-year-old male who presented with a six-month history of increasing right cheek swelling. | not china |
All the patients previously received multiline treatments and failed with an estimated survival less than 6 months. | china |
Patients with Child C classification had longer survival by 1.6 years in the study group (p = 0.006). | not china |
GSCs contribute to tumor heterogeneity and recapitulate pathway alterations described for the three GBM subtypes found in patients. | not china |
Furthermore, safety data were described. | not china |
We also investigated the anti-tumor effects of the treatment combining miR-34a with 5-FU in breast cancer cells. | china |
Prognostic and predictive associations with disease-free survival (DFS) and overall survival (OS) were evaluated by Cox regression with false discovery rate (FDR) adjustment. | not china |
In the latter case, PCI was given immediately after the end of thoracic radiotherapy and prior to the last cycles of chemotherapy to a total dose of 30 Gy in 2-Gy fractions to the whole brain. | not china |
With an increase in the CIK concentration, the survival rate of the SKVCR cell lines showed a decreasing trend. | china |
How to match the special microenvironment to on-demand drug release is the key to improve chemotherapeutic efficacy. | china |
C-choline PET was further performed to reveal the pathological property of the kidney lesion, and high uptake was noticed. | china |
(131)I single photon emission computed tomography/computed tomography ((131)I-SPECT/CT) can provide both metabolic and anatomic information about a lesion; therefore, it can better localize and define the (131)I-WBS findings in DTC patients. | china |
Hypocalcemia and hypophosphatemia were frequent, but did not result in clinical symptoms. | not china |
In this study, we evaluated the mRNA and protein levels of CAPN2 in human RCC specimens, matched normal specimens, and RCC cell lines using quantitative Real-time PCR (RT-PCR) and western blot. | china |
In a single center study, we measured triglycerides (TG), total cholesterol (TC), high (HDL) and low density lipoproteins (LDL) levels at diagnosis and assessed the association with BMI, early therapy response, on-therapy hyperlipidemia and the toxicities; thromboembolism, osteonecrosis and pancreatitis. | not china |
In multivariate Cox regression analysis, SLNRT could be confirmed as an independent predictor for increased PSA progression-free survival (PFS; HR 0.08, 95%CI 0.040 - 0.142, p<0.001). | not china |
In addition, the effect of PON1 on renal cancer cells was verified by experiments in vivo. | china |
Sera from 150 cases and 314 controls matched on date of blood draw, age at blood draw, and region was used to determine concentrations of 11 OC pesticide metabolites and 34 PCB congeners. | not china |
Biliary cancers are highly aggressive tumors that are often diagnosed an advanced disease stage and have a poor outcome with systemic therapy. | not china |
Our 'real-world' experience shows that unselected older patients represent a significant larger proportion in real life than in RCTs; furthermore, older patients in a real-world setting may experience more side effects possibly affecting the quality of life. | not china |
Results: A prognostic model containing nine HRGs (STC2, ALDOA, MIF, LDHA, EXT1, PGM2, ENO3, INHA, and RORA) was developed. | china |
The NF-κB1 - 94ATTG deletion was associated with increased IL-6 and IL-10 in DLBCL. | not china |
A total of 187 patients with osteosarcoma were administered methotrexate, cisplatin/adriamycin, actinomycin D, cyclophosphamide, or vincristine. | china |
However, the characteristics of Lin28 and its mechanism of action in chemotherapy resistance is still unclear. | china |
Results The PORT group included a high number of margin-positive cases. | not china |
We successfully created a new rat model with orthotopic pancreatic head cancer, which can be accurately monitored and visualized by different imaging modalities. | not china |
(4) Conclusions: The level of knowledge of the surveyed students of the Silesia Province is unsatisfactory. | not china |
Five to ten representative original multispectral images of each sample were employed in the analysis. | china |
SPECT imaging with (131)I-tRRL clearly visualized tumors in nude mice, especially at 24 h. Radioiodinated tRRL offers a noninvasive nuclear imaging method for functional molecular imaging of tumors targeted to neovascularization, and may be a promising candidate for tumor radioimmunotherapeutic carrier. | china |
The endpoints of follow-up were all-cause death, local progression or distant metastasis. | china |
Triple-negative breast cancer is the most aggressive form of breast cancer with limited intervention options. | not china |
With the discovery of anticancer peptides, great progress has been made in cancer treatment. | china |
It remains a matter of debate as to how the Warburg effect is regulated during tumor progression. | china |