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Recent studies have suggested that mild hyperthermic (38 degrees C) ILI might be the best initial treatment for extensively recurrent limb melanoma given its simplicity, low morbidity and a complete response rate of 30 - 40%. | not china |
The efficacy of Disitamab Vedotin (RC48), a Her-2-targeted ADC, was evaluated in PSCC. | china |
However, poor tolerability limits its clinical application. | china |
Among them, compounds 5k and 5i exhibited equivalent vitamin D3-agonistic activity compared with Calcitriol. | china |
They were assigned into two groups, including the CAD and non-CAD groups, based on coronary angiography or computed tomography angiography findings. | china |
We observed that PmMN@Om&As exhibited a high total drug-loading capacity (33.77 wt %) and good immune escape. | china |
To understand the state-of-the-science in this regard, we reviewed neuroimaging studies with cancer patients that examined the associations between negative affect (distress) and changes in the metabolism or structure of brain regions. | not china |
Such versatile nanocarrier can influence the physicochemical characteristics, immunological mechanisms, and uptake mechanisms following systemic delivery. | not china |
JPH203 interfered with constitutive activation of mTORC1 and Akt, decreased expression of c-myc and triggered an unfolded protein response mediated by the C/EBP homologous protein (CHOP) transcription factor associated with cell death. | not china |
The survival rate in the macroscopically complete resection group was higher than in the incomplete resection group (P < .001). | not china |
In women at increased breast cancer risk for genetic predisposition or positive family history, data regarding these risk factors are limited or conflicting, and recommendations for these categories are unclear. | not china |
Schwannomas are tumors arising from Schwan cells of the neural sheath, which rarely occur in the gastrointestinal tract. | china |
In silico and cell biological analysis of IDH1 dimerization revealed that the Y208C mutation, but not the R132H mutation, attenuated binding activity with WT cIDH1. | not china |
Although several drugs provided an impressive outcome benefit, the most effective sequential strategy is still unknown. | not china |
Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. | china |
This phase I trial was conducted to test whether vaccine EMD640744, a cocktail of five HLA class I-binding survivin peptides in Montanide(®) ISA 51 VG, promotes anti-survivin T-cell responses in patients with solid cancers. | not china |
Suicide rates and SMRs among these patients were calculated, and the general population of the United States (U.S.) during 1975-2016 was used as a reference. | china |
ERCC1 protein expression status is significantly associated with response to platinum-based chemotherapy in ovarian cancers. | china |
T stage and number of positive lymph nodes significantly influenced the survivals indicating the heterogeneity of stage IIIC1 cervical cancer patients. | china |
Based on modelling with meta-analysis of comparative survival data, leuprorelin 22.5 mg was the most cost-effective treatment of the available depot formulation LHRH agonists. | not china |
Glioblastoma is the most common primary brain tumor in adults with a dismal prognosis. | not china |
This trial failed to demonstrate that methylphenidate treatment in selective serotonin reuptake inhibitor-treated patients had a significant effect on depression remission in patients with advanced cancer. | not china |
Therefore, it is crucial to identify more effective therapeutic targets. | china |
Metastatic melanoma has poor therapeutic response and may present resistance to chemotherapy or immunotherapy. | china |
Specifically, this machine measures glycolysis by analyzing the extracellular acidification rate (ECAR) and measures mitochondrial oxidative phosphorylation on the basis of the oxygen consumption rate (OCR), through real-time and live cell analysis. | not china |
In summary, healthy diet decreased UGI cancer risk, and individuals with high genetic risk can attenuate UGI cancer risk by adopting a healthy diet. | china |
Substituting A. annua capsules by artesunate injections (2 × 150 mg twice weekly i.v.) | not china |
Therefore, EGFR gene mutations in exons 19 and 21 in Chinese patients with LELC of the lung were investigated. | china |
Epidermal growth factor receptor (EGFR) targeted therapy has been applied in advanced common NSCLC. | china |
Diagnostic performance of mpMRI, PET/CT and their combination (com-MRI/PET) on ECE and SVI on a patient basis were analyzed. | china |
The electrochemical results reveal that Zr-MOF facilitates aptamer strand immobilization, whereas the Zn-MOF stabilizes the G-quadruplex formed by aptamer strands and PTK7. | china |
Thus, our findings have revealed a role of CENP-E in immunotherapy and suggest that combination of CENP-E inhibitor with PD-L1 antibody could be an effective treatment option for NSCLC. | china |
Systemically administered CEA-specific (but not control) CAR Tregs accumulated in the colons of diseased mice. | not china |
The third generation bisphosphonate zoledronic acid has demonstrated efficacy in reducing skeletal-related events in adult patients with multiple cancer types that have skeletal disease. | not china |
The paradoxical roles of transforming growth factor-β (TGFβ) signaling and nuclear receptor Nur77 in colon cancer development are known but the underlying mechanisms remain obscure. | china |
Additionally, we analyzed immune cell infiltration and the level of methylation in ccRCC patients. | china |
In the present study, we report a case of ACC treated with EDP-M plus sintilimab. | china |
From 2005 to 2009, 31 patients with AT/RT from four countries were recruited into the registry study Rhabdoid 2007 and treated with systemic and intraventricular chemotherapy. | not china |
Cox proportional hazard regression model was used to analyze predictors of gastric cancer. | china |
Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. | not china |
A genome-wide CRISPR knockout screen investigating resistance to doxorubicin and cytarabine (Dox/AraC) in human AML cell lines identified gene knockouts involving AraC metabolism and genes that regulate cell cycle arrest (cyclin dependent kinase inhibitor 2A (CDKN2A), checkpoint kinase 2 (CHEK2) and TP53) as contributing to resistance. | not china |
We propose a new multi-threshold image segmentation model based on the two-dimensional histogram approach to the above problem. | china |
When including treatment data, rs11085735 was associated with recurrence-free survival (RFS; P = 0.020; HR, 1.545) and breast cancer-specific survival (P = 0.016; HR, 1.683) and rs34197572 with overall survival (P = 0.045; HR, 1.304). | not china |
Histological examination revealed a small focus with distinct morphological features similar to clear cell RCC encased in the otherwise typical IDC. | not china |
Low serum sodium has been associated with unfavorable outcome in several cancers. | china |
In the univariate analyses, the OS was impaired for patients aged ≥ 4 years (p = 0.001) with the initial biopsy (p = 0.016), tumor spillage (p = 0.028), incomplete tumor resection (p < 0.001), unfavorable histology (p = 0.047), and COG stages III/IV (p = 0.002). | not china |
We aimed to investigate the associations between diabetes and quality of life (QOL) among breast cancer survivors. | china |
Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. | china |
Until recently, the patient's lung metastases have basically disappeared and no disease progression has been observed. | china |
The ROC analysis showed that Perc.99 (AP) generated the best diagnostic performance with the area under the curve, sensitivity, and specificity being 0.960, 86.67%, and 93.33%, respectively, when using 71.00 as the optimal threshold. | china |
The idea that breast cancer is an aging disease has apparently broken in the case of BCYW due to the young onset and an overall poor outcome of BCYW patients. | not china |
Moreover, the precise drug delivery of TPNPs towards tumor cells significantly diminished the toxic side effects caused by concurrent administration of Ada and Ola. | china |
In this review, we will provide a detailed profile of verified neoantigens in AML, describe the strategies to identify neoantigen-specific TCRs, and discuss the potential of neoantigen-specific T-cell-based immunotherapy in AML. | china |
Mechanically, IRS2e is essential for the expression of insulin receptor substrate 2 (IRS2), an oncogene nearby IRS2e in chromosome 13. | china |
To explore the ability to release ZOL from the ZOL/β-TCP, the amount of released ZOL was measured. | not china |
To evaluate the prevalence of adverse pathological features and the percentage of multifocal and/or bilateral disease in a series of patients who underwent radical prostatectomy (RP) for unique, microfocal prostate cancer (miPCa) detected on prostate biopsy in the pre-active surveillance (AS) era. | not china |
Pre-operative SD2 was significantly associated with post-operative PLR, with each 1-unit increase in SD2 decreasing the PLR value by 2.4 ± 0.9 (P < 0.05). | china |
We present a 36-year-old man with a new, tender 3-mm firm pink papule on the left bicep, in which a superficial shave technique produced a diagnostic challenge. | not china |
The HUNT 1 physical activity questionnaire (HUNT 1 PA-Q) was compared to the International Physical Activity Questionnaire (IPAQ) and aerobic capacity. | not china |
PSA persistence was associated with disease recurrence in a sub-group of patients with pathological nodal involvement (HR: 5.90, 95% CI: 3.76-9.24). | not china |
DWI, DKI, and PET in PET/MRI are all effective methods to distinguish benign from malignant SPLs, and are also helpful in evaluating the pathological grading of malignant SPLs. | china |
Reverse transcription-quantitative polymerase chain reaction analyses and subcellular fractionation assays showed that ACTA2-AS1 was lowly expressed in GC cells and was mainly distributed in the cytoplasm. | china |
Then we identified deep learning radiomics on magnetic resonance imaging with dynamic contrast enhancement (DCE-MRI) in predicting axillary response after NAC in BC patients. | china |
The lead compounds, 82, 91 and 95, potently inhibited the growth of cancer cells by inducing G1 arrest with a concomitant reduction in the phosphorylation of Rb at S780 and in E2F-regulated gene expression. | not china |
A large proportion of patients (189) had high grade tumors. | china |
SUMOylation of TUFT1 is mediated by the E3 SUMO ligase tripartite motif-containing protein 27 (TRIM27), and these two proteins regulate the malignant behavior of GC cells and AKT activation in the same pathway. | china |
The first handbook and clinical practice guide providing unique SDM support material for health professionals have been developed. | not china |
Giant cell tumours, though benign, are locally aggressive bone tumours with a relatively high recurrence rate. | not china |
Healthy diet, based on "healthy diet score," was determined according to fruit, vegetables, grains, fish, and meat consumption. | china |
The relationship of the clinical features, prognosis and specific gene mutations was researched. | china |
Efficacy was evaluated with objective response rate (ORR, immune-Response Evaluation Criteria in Solid Tumours [RECIST] criteria) progression-free survival (PFS) and overall survival (OS). | not china |
In this patient, radical laparotomy and adjuvant chemotherapy were performed. | not china |
At baseline the association between ideal health behaviors and the SCES was significant for fruit intake (r = 0.22, p-value = 0.003) and red meat consumption (r = 0.17, p-value = 0.02). | not china |
The generated seleninic acid could downregulate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) to inhibit angiogenesis and further relieve hypoxia. | china |
Pancreatic cancer (PC) is one of the most lethal malignancies, which is generally resistant to various treatments. | china |
Neoadjuvant chemotherapy (NAC) has become the best comprehensive treatment choice for breast cancer. | china |
The patient is currently being followed-up for more than 2 years to evaluate the duration of the response. | china |
The tumor was resected when the patient was 6 months of age, and radiation therapy (40-Gy total dose) was performed thereafter. | not china |
No patients experienced surgical complications greater than Clavien-Dindo grade I. | china |
CTC counting was associated with TNM stage (P = 0.014) and distant metastasis (P = 0.007). | china |
Using bioinformatics analysis and immunoprecipitation assays we found that ZC3HAV1 could directly bind to KRAS and positively regulate its expression. | china |
XIAP KD cells were more sensitive to etoposide, Rsv, vincristine and doxorubicin compared to wild-type (WT) cells. | not china |
No significant association was retrieved with CXCL12-3'A polymorphism. | not china |
Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels. | china |
Cell migratory ability was assessed through Transwell and wound healing assays. | china |
FTO was predicted to be the target gene for microRNA-1266, which was negatively regulated by microRNA-1266. | china |
Potential applicable drugs and targets were mined in the APMrs-high group. | china |
Given that Krm2 is abundantly expressed in most tested gastric cancer cell lines, Krm2 knockdown cell models were established and further used to construct mice xenograft model. | china |
Ten variables were screened out after LASSO-COX analysis, including age, tumor stage, EGFR c.[2,573 T>G], PIK3CA c.[1624G>A], TP53 c.[375G>T], TP53 c.[527G>T], TP53 c.[733G>T], TP53 c.[734G>T], TP53 c.[743G>T], NFE2L2 c.[100C>G]. | china |
Furthermore, we show that LASP1 can interact with eIF4A and eIF4B through a GST-pulldown approach. | not china |
One patient in Arm C achieved a durable partial response by RECIST criteria, lasting for approximately 19 months. | not china |
Consecutive patients with lung malignancies were retrospectively evaluated between January 2016 and December 2019. | china |
Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). | china |
In the present study, we investigate the role and clinical significance of PS-1 in GC. | china |
It is critical to ascertain the diagnosis in order to initiate most advantageous treatment of the suspicious lesions. | not china |
3) A clinical-radiomics model: it was built by integrating radiomics signature and independent predictive clinical factors by logistic regression. | china |
DEPs mainly enriched on caveolae of cellular component, calcium ion binding of biological process and epithelial cell migration of molecular function. | china |
Sestrin 2 overexpression also activated the adenosine monophosphate-activated protein kinase (AMPK) pathway, and suppressed mTORC1 signaling. | china |
Beyond 5 years, an increased risk was maintained for lung, oesophageal, liver and bladder cancers, squamous cell carcinoma of the skin, lymphoma and multiple myeloma. | not china |
Moreover, for patients older than 60 years, there were no statistically significant differences in OS and PFS, whereas milder nausea and vomiting was observed in the h-R3/RT group (p = 0.020). | china |