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KLF5, GATA4 and GATA6 amplifications were confirmed in independent GC cohorts. | not china |
Furthermore, overexpression of Rap2c induced lung metastasis of glioma cells in xenograft models. | china |
In the present study, we aimed to investigate the underlying mechanism and further evaluate the clinical value of let-7e in predicting chemo-response and prognosis in EOC. | china |
The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. | not china |
In patients with bladder metastasis, absence of metastases in other organs and an interval of more than 1 year after nephrectomy are known to be favorable prognostic factors. | not china |
LINC00968 expression is markedly upregulated in EOC. | china |
Results: Compared with normal tissues, the expression levels of UPF1 mRNA and protein in tumor tissues of ccRCC patients decreased significantly. | china |
Both patients and physicians reported no experiences with video consultations during the COVID-19 pandemic, but 15% of patients stated that they missed telemedicine services that would include a video call. | not china |
The aim of this study was to establish a prognostic risk model for patients with triple negative breast cancer (TNBC). | china |
The conclusion is that all the SHM molecular data gathered since 1980 supports directly or indirectly the RNA/RT-based mechanism. | not china |
Older adults are under-represented in randomised clinical trials (RCTs), and those who are enrolled have a good performance status and no major health issues. | not china |
We retrospectively collected the data of 227 patients with PT3N0M0 esophageal cancer (EC). | china |
ROR1-CARs containing a short "Hinge-only" extracellular spacer conferred superior lysis of ROR1(+) tumor cells and induction of T-cell effector functions compared with CARs with long "Hinge-CH2-CH3" spacers. | not china |
IFN-γ or TNF-α treatment upregulated the protein level of PTPN2. | china |
In 104 patients with EC who met study inclusion criteria, 81 (77.9%) had TLSs, which consisted of areas rich in CD20+ B cells, CD8+ T cells, CD4+ T cells, and CD38+ plasma cells. | not china |
To compare the survival outcomes of neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy with hepatectomy alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). | china |
This review identified the advantages and disadvantages associated with improving health care and outcomes. | china |
The molecular mechanism for GCA is largely unknown. | china |
The m6Ascore applied in three immunotherapy cohort (GSE78220, TCGA-SKCM, and IMvigor210) did not exhibit a good prediction for estimating the patients' response to immunotherapy, so it may need more researches to figure out whether the m6A modulator prognosis model would benefit the prediction of pancreatic patients' response to immunotherapy. | china |
In our population, HE4 did not correlate with the histological grade, endometrial cancer type I versus type II (P = 0.86), the lymphovascular infiltration (P = 0.12), and the cervical invasion (P = 0.6). | not china |
The key molecular events required for the formation of ductal carcinoma in situ (DCIS) and its progression to invasive breast carcinoma have not been defined. | not china |
Patients had nonmyeloid malignancies, hemoglobin levels ≤10 g dL(-1), and no iron deficiency. | not china |
Transwell assay was utilized to analyze HCC cell migration and invasion. | china |
These results indicate that T4 induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. | china |
Pediatric brain tumor derived neurospheres may provide a predictive model for preclinical explorations. | not china |
Evaluation of m6Ascore for immunotherapy was analyzed via the IPS and three immunotherapy cohort. | china |
Preoperative serum sodium and clinicopathological indexes were retrospectively analyzed in 2155 patients who underwent esophagectomy at Sichuan cancer hospital. | china |
Univariate and multivariate analysis showed that the C10orf10 expression was an independent prognostic factor for overall survival of breast cancer patients. | china |
While many studies have exploited public resources such as RNA sequencing (RNA-Seq) data in The Cancer Genome Atlas to study lncRNAs in cancer, it is crucial to choose the optimal method for accurate expression quantification. | not china |
This study was the first to report a comparative profiling of immune genes in large LGG cohorts. | china |
However, they did not consider the measurement error in the estimated number of stem cell divisions, which is caused by the exposure to different levels of genetic and environmental factors. | china |
Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. | china |
Histone deacetylase (HDAC) inhibitors (HDIs) can modulate the epithelial-mesenchymal transition (EMT) progression and inhibit the migration and invasion of cancer cells. | not china |
Nilotinib was switched because of failure to achieve complete cytogenetic response at 6 months following Imatinib. | not china |
The hedgehog signaling pathway plays an important role in EMT of pancreatic cancer cells, but the precise mechanisms remain elusive. | china |
This study aims to identify differentially expressed proteins related with platinum sensitivity and to find biomarkers for predicting platinum response and survival outcomes in patients with high-grade serous ovarian cancer (HGSOC). | china |
Cytologic and histopathologic examination of the skin lesions revealed cutaneous epitheliotropic lymphoma. | not china |
Delays in time to antibiotic of up to 3 hours did not impact outcomes. | not china |
After PSM, alpha-fetoprotein (AFP) ≥ 400 μg/L [hazard ratio (HR) = 4.71, 95% confidence interval (CI): 2.69-8.25], ascites (HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists (ASA) classification (III vs. II) (HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm (HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. | china |
A portable dual wavelength excitation fluorescence imaging system was built and tested in parallel with an NIR tumor-targeting fluorophore in tissue mimicking phantoms, chicken tissue, and in vivo mouse models of breast cancer. | not china |
This study is to explore clinical workflow patterns for CRC patients using electronic health records (EHR). | not china |
In pre-clinical research aiming at the identification of novel treatment targets, the need for representative cell lines and model systems is high, but availability is scarce. | not china |
We selected four lncRNAs including LINC00152, CASC9, LINC00226 and F11-AS1 for validation in PDAC cell lines and normal cells. | china |
The aims were to identify candidate genes upregulated in colorectal cancer cell lines resistant to anti-EGFR monoclonal antibody treatment, to knockdown (KD) these genes in the resistant cell lines to determine if sensitivity to anti-EGFR antibody was restored, and finally to perform a pilot correlative study of EGR1 expression and outcomes in a cohort of metastatic colorectal cancer (mCRC) patients given cetuximab therapy. | not china |
Xanthohumol suppressed the proliferation, foci formation, and anchorage-independent colony growth of KYSE30 cells. | china |
Variations in the elemental levels with different types of lymphoma (non-Hodgkin and Hodgkin) were also evaluated. | not china |
Until now, this is the first nomogram that predicts PCa and csPCa in biopsy-naïve patients with PSA <10 ng/ml and PI-RADS v2.1 = 3 lesions. | china |
The patient outcome compared favorably with other adjuvant trials in preventing relapse, particularly distant relapse which is predictive of poor outcome. | not china |
Besides, IL-6 could accelerate OSCC cell proliferation by activating inflammasome via JAK2/STAT3/Sox4/NLRP3 pathways in vitro and in vivo. | china |
The SP activity showed positive correlations with tumor mutation burden (TMB) and aneuploidy in diverse cancers, suggesting its association with genomic instability. | china |
These results could be used as a first approach to characterize and standardize CAS to validate the potential health benefits derived from its consumption. | not china |
Despite remarkable improvements in screening, diagnosis, and targeted therapies, cancer remains the second leading cause of death in the United States. | not china |
Our findings suggest that somatic mutations in CCK2R may promote tumorigenesis through deregulated receptor activity and highlight the importance of evaluating CCK2R inhibitors to block both the normal and mutant forms of the receptor. | not china |
Ectopic expression of AVPR1A in androgen-dependent PC cells conferred castration resistance in vitro and in vivo. | not china |
Long non-coding RNAs (LncRNAs) have been widely studied and aberrant expression of lncRNAs are involved in diverse cancers. | china |
Although the specificity of AFB + WLB is lower than WLB alone, AFB + WLB seems to significantly improve the sensitivity to detect intraepithelial neoplasia. | china |
We therefore propose a vicious cycle encompassing neutrophils and Snail to maintain a deleterious tumor microenvironment. | not china |
Tetrandrine, a bisbenzylisoquinoline alkaloid, has antitumor effects against some cancers. | not china |
Here, we aim to investigate the role of hypoxia-induced autophagy and the mechanistic actions of the bioinformatically identified BNIP3 in BC. | china |
In conclusion, this meta-analysis provides evidence that CYP1B1 Leu432Val polymorphism is not associated with prostate cancer risk overall with the exception in Asians. | china |
BCL-2 expression decreasing was found only in UT-7 leukemia. | not china |
Furthermore, alterations in SWI/SNF complex subunits, especially in ARID1A/1B/2, SMARCA2/4, and BCL7A, are highly recurrent across a wide variety of lymphoid and myeloid malignancies. | not china |
We included 127 children (1.0-17.9 years) all treated according to the NOPHO ALL2008 protocol. | not china |
Among 78,215 women enrolled in PLCO, there were 1211 in-situ and 4790 invasive BrCA cases. | not china |
159 3D treatment planning datasets were available for analysis. | not china |
DNA sequencing data from an additional 1,312 patients were used to confirm the prevalence of HR pathway alterations in LMS. | not china |
PRDX2 and p-AKT protein expression were analyzed by immunohistochemistry technology in human colon carcinoma tissues. | china |
Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. | not china |
In this systematic review and meta-analysis, we evaluated the association between metformin, sulfonylureas (SUs), insulin, and the risk of EC in patients with diabetes mellitus (DM). | china |
The FMSN-MnO2 -BCQ with FMSN framework featuring a stepwise degradability in tumor interior released MnO2 and BCQ nanoparticles. | china |
ROC curve analysis revealed an optimal threshold for ΔSUV(max) of 40% during CRT and 76% after CRT. | not china |
This study was based on pre- and post-test, 2 group, quasi-experimental design. | not china |
Visual and semi-quantitative analysis was performed on both early and delayed images. | not china |
A prospective clinical trial (NCT03061162) is ongoing to validate our results. | china |
In this study, we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1. | china |
The results showed negative attitudes of participants regarding control of cancer pain. | not china |
In human EOC tissues, BRCA1 and Rad51 levels were increased in the chemo-resistant group compared with the sensitive group and were negatively correlated with let-7e. | china |
The higher awareness among the students of medical universities results from the presence of issues related to microbiota and CRC in the medical educational content. | not china |
A total of 2062 patients with NSCLC patients who had undergone thoracotomy were retrospectively examined. | china |
Moreover, treatment with Ad-HBx-mIL-12 not only induced a massive accumulation of immune cells (CD8(+) T leukocytes, macrophages and dendritic cells) in tumors in situ, also apparently reduced the number of angiogenic blood vessels within tumor tissues. | china |
Previous investigations reported that circRNAs harbor indispensable roles in modulating the progress of multiple cancers. | china |
Herein, we studied the effect of labile iron (ferric chloride) on the progression of liver cancer cells (HepG2.2.15). | not china |
A series of functional experiments were performed to assess the roles of UPF1 in renal cancer cells. | china |
Most therapies are directed at the fast growing tumor mass but not the slow dividing cancer stem cells. | china |
Eighteen patients experienced disease relapse after combined treatment; in five of these patients, relapse was both locoregional and systemic. | not china |
Targeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. | not china |
Acute promyelocytic leukemia (APL) is an uncommon malignancy in the pediatric population, accounting for only 5-10% of pediatric acute myeloid leukemias, and for this disease to present with bone lesions at diagnosis is extremely unusual. | not china |
Chemotherapy treatments, such as 5-fluorouracil (5-Fu), play a key role in the current management of colon cancer. | china |
Lactic acid bacteria can provide benefits to human beings and transform phenolic substances to improve their potential functionality. | china |
Significant correlations between the expression of KIAA0101 protein and p53 and Ki-67 proteins were observed in this study. | not china |
The phase II dose of VSLI may be recommended as 4 doses of 1.5 mg·m(-2) for treatment of patients with advanced solid tumors. | china |
Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. | china |
A biological model incorporating both transcriptional and metabolic dysregulation was also established to illustrate the potential mechanism of tumorigenesis and metastasis for ESCC. | china |
Invasion and metastasis of colorectal cancer (CRC) are leading causes of death of CRC patients. | china |
We further detected the effects of Fyn on the proliferation, apoptosis, migration, and invasion of the pancreatic cancer cells through colony formation assay, flow cytometry (FCM) assay, wound healing assay, and transwell assay, respectively. | china |
Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor. | china |
T-cell lymphoma has the worst prognosis with a shorter survival time and disease-free interval. | not china |
The single nucleotide polymorphism G-308A in the TNF-α gene increases the level of this cytokine. | china |
The densities of CAFs and TAMs were measured by immunohistochemistry staining for α-smooth muscle actin (α-SMA), CD68, and CD163 in two sets of tissue microarrays including 260 pretreatment NPC tissues, that is, a training test comprising of 152 patients and a validation set comprising of 108 patients. | china |
Conversely, for patients aged ≥ 70 years, the Perry regimen should be preferred. | not china |