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However, the overall response rate of anti-PD-1/PD-L1 monotherapy is still unpromising, underscoring the need for predictive biomarkers. | china |
This review will discuss resistance to checkpoint inhibitors in melanoma as well as possible methods to restore sensitivity. | not china |
Colorectal cancer (CRC) is leading malignant tumors to occur mainly in industrialized countries, where it exhibits one of the highest mortality rates. | not china |
The poor prognosis for patients with hepatocellular carcinoma (HCC) is related directly to metastasis. | not china |
Longitudinal observations on the efficacy of A. annua in patients are, however missing as of yet. | not china |
We found the expression of protein kinase C zeta increased in prostate cancer tissues, especially in the early stage, and was negatively associated with tumor grade and the number of CD206+ macrophages. | china |
Given its role in tumor inhibition, no research has been conducted concerning its effect against melanoma. | china |
Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. | china |
Among responding patients, 310 were undergoing active treatment and 158 were in follow-up care. | not china |
The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction ≤5 mm Hg of 30-50%. | not china |
In contrast, estrogen receptor α (ERα) helps to maintain the epithelial phenotype of breast cancer cells and its expression is crucial for effective endocrine therapies. | not china |
Gallbladder cancer is a rare malignancy and double cancer of the gallbladder is extremely rare. | not china |
The aim of this review is to summarize the existing data regarding pathogenesis, diagnosis, and treatment. | not china |
Thus, our results suggested that PTX/PECT(gel) may have great potential applications in IP chemotherapy. | china |
Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. | china |
Finally, the mean of MGMT methylation levels was significantly higher in the cancerous group than in the control group (6.25±1.702 vs. 0.086±0.036, p<0.001). | not china |
The clinical records of consecutive patients with metastatic NSCLC who received pemetrexed after failed first-line chemotherapy were reviewed. | china |
Further in vivo studies or clinical trials are needed. | china |
The presence of CA19-9 × CEA ≥500 had the largest attributable risk proportion because of its combined high predictive performance and prevalence. | not china |
Particularly, we focused on the role of tumour immune microenvironment, generally characterised by strong barriers for immunotherapy, and we discuss the rationale for the potential application of single agent and combination immune-targeting strategies that could lead to improved outcomes. | not china |
The aim of this retrospective study was to automate this process. | not china |
The results of the quantitative analysis indicated that cancer patients where not more likely to have greater knowledge of cancer signs and symptoms than women without cancer. | not china |
We included 352,911 individuals (37.2% with MAFLD), among whom 23,345 developed cancers. | china |
We compared the long-term survival rates of both treatment groups and analyzed the possible factors affecting OS. | china |
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor originating from proximal tubular epithelial cells, and despite extensive research efforts, its redox homeostasis characteristics and protein S-nitrosylation (or S-nitrosation) (SNO) modification remain largely undefined. | china |
Some patients with exophytic renal masses less than 4 cm and suboptimal renal function, or a solitary kidney and bilateral renal tumors are considered for laparoscopic partial nephrectomy (LPN), which is feasible for early-stage renal tumors, although it is still considered technically difficult and time consuming. | china |
Public health efforts should be directed toward addressing the increase in the diagnoses of metastatic PC. | not china |
Liver resection to treat HCC is safe in patients with preserved liver function and good functional status. | china |
Treatment of patients with metastatic brain disease from breast cancer should be tailored to the patient's hormonal status and GPA index. | not china |
Furthermore, a subgroup analysis was conducted to evaluate which of the two commonly used methods of LG, laparoscopic-assisted gastrectomy (LAG) and totally laparoscopic gastrectomy (TLG), is more suitable for obese patients. | china |
We show here that R736H leads to a moderate reduction in catalytic activity of 20-40% depending on the substrate, but no changes in CpG specificity, flanking sequence preferences and subnuclear localization. | not china |
Patients with low CD86+ TAMs and high CD206+ TAMs infiltration had a markedly worse prognosis and increased risk of post-operative recurrence when compared to high CD86+ TAMs and low CD206+ TAMs intratumoral infiltration. | china |
A total of 620 radiomic features were extracted. | china |
Participants believed that cancer pain medications do not manage cancer pain at acceptable levels; patients may become addicted by using these drugs; cancer pain medications have many uncontrollable effects; and controlling cancer pain may distract the physicians from treating disease. | not china |
Acquisition of standardized data including reference diagnosis and a standard treatment schedule improved data quality along with a survival benefit. | not china |
In addition, we analyzed the potential of using cuprotosis in clinical treatment from multiple perspectives, including chemotherapeutic drug susceptibility test, immune target inhibition treatment responsiveness, and histone modification. | china |
We used directed acyclic graphs to present a framework for considering potential biases arising in aetiological research of tumor subtypes, when there is incomplete correspondence between the identified subtypes and the underlying pathogenic mechanisms. | not china |
Nine genera and 25 species of bacteria were identified. | not china |
There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson's disease (PD). | china |
The inflammation-mediated/related carcinogenesis pathways reported in OSCC involves COX-2, epidermal growth factor receptor (EGFR), p38a MAP kinase, NF-kB, STAT, RhoC, PPARy, etc. | not china |
We demonstrated that the anti-proliferative effect of the HDACi vorinostat is paralleled by the induction of TG2 mRNA and protein expression in cancer cells but not in ex vivo treated peripheral blood lymphocytes. | not china |
During 2010-2013, PSA screening rates in men aged 50-74 years declined from 39 to 32 per 100 men and remained stable. | not china |
It has been well-established that the deubiquitinating enzyme ubiquitin-specific peptidase 7 (USP7) supports cancer growth by up-regulating multiple cellular pathways, including Wnt/β-catenin signaling. | china |
Primary MCC was located on the malar/zygomatic (34.4%), forehead/frontal (13.5%), and nasal (13.5%) regions. | not china |
Out of the eight patients, four were males and four females. | not china |
A total of 136 radiation-associated DEGs preradiation and postradiation BCa samples were screened out. | china |
However, their cytological features have not been described till date. | not china |
To date, the impact of survivin on IGF-1-mediated EMT of GC has not been featured. | china |
We assigned a risk score to each lung adenocarcinoma patient based on the expression of the differentially expressed ion channel genes. | not china |
Gel shift assay was used for analysis of transcription factor nuclear factor-κB (NF-κB) activation. | not china |
Then, slides of the FNA samples were prepared by liquid-based cytology (LBC) (ThinPrep system, Hologic) according to the manufacturer's instructions, and a PathVision HER2 DNA probe kit (Abbott) was used for FISH staining. | not china |
Thus, the presence of a MSI/IHC abnormality prompts further investigations to diagnose Lynch syndrome, whereas its absence excludes Lynch syndrome. | not china |
One hundred and ninety-four patients with clinical and radiographic data were evaluated retrospectively following surgical resection of primary RT. | china |
Additionally, SNP-environment interactions for rs12427129, rs3816153, and HBsAg status were found to enhance the risk of HCC, with FDR-P as an additive interaction equal to 0.0006 and 0.0144, respectively. | china |
However, whether the aberrant expression of miR-215 in breast cancer is associated with malignancy, metastasis, or prognosis remains unknown. | china |
We found that high TTTY14 expression was a poor survival prognostic factor in TGCT patients and the expression of TTTY14 might be regulated by copy number variation and DNA methylation. | china |
This proposes new strategies for implementing hyperthermia to target c-Myc-driven cancers to improve therapeutic efficacy. | china |
The expression of ATAD2 and KIF4A was upregulated in ESCC tissues, and both were correlated with the differentiation grades and lymph node metastasis. | china |
Student's t-test showed that plasma anti-CD25 IgG levels were significantly higher in HCC patients than control subjects (t = 4.96, P < 0.001), in which male patients mainly contributed to the increased IgG levels (t = 5.11, P < 0.001). | china |
Luciferase gene-labeled human primary hepatic carcinoma cell line MHCC97-H successfully infected 20 nude mice, and OIIT showed that the two groups exhibited metastasis after local tumor resection, but there were more tumor cells in the control group (P < 0.05). | china |
Optimal synapse formation is not only critical for the generation of effective immunity against pathogens but is also essential for immune surveillance against cancer and for the prevention of immune disorders. | not china |
Cell proliferation was significantly inhibited by TP. | china |
Bacterial diversity decreased as antineoplastic treatment progressed and increased at the end of therapy. | not china |
A Friedmańs test was used to investigate differences in the mean number of Tregs across histological lesions. | not china |
The present study evaluated the occurrence of SSTR subtypes 1, 2, 3 and 5 as well as the possible role that each subtype plays in the clinical evolution of patients with MTC. | not china |
In this study we compared the activities of BEN against that of the alkylating agent, chlorambucil (CLB), and the nucleoside analogs, fludarabine (FLU) and deoxyadenosine/pentostatin (dADO/PEN), in primary chronic lymphocytic leukemia (CLL) cells in vitro. | not china |
Furthermore, ZFP91 is positively associated with HIF-1α in human colon cancer. | china |
Methanolic extracts of all plant species displayed high antioxidant contents (equivalent to approximately 7-16 mg of vitamin C per gram of fruit extracted). | not china |
Therefore, antisense proteins of HTLV-1 and HTLV-2 have evolved different functions in vivo, and further comparative studies will provide fundamental insights into the distinct pathobiologies of these two viruses. | not china |
Adjusted ORs for high residential cumulative exposures to tetrachloroethylene (PCE), t-1,2 dichloroethylene (DCE), and vinyl chloride were 1.20 [95% CI: 0.16-5.89], 1.50 [95% CI: 0.30-6.11], 1.19 [95% CI: 0.16-5.89], respectively, with a monotonic exposure response relationship for PCE only. | not china |
We used microsimulation modeling to estimate the consequences of time to colonoscopy after a positive result from a fecal immunochemical test (FIT). | not china |
NFPC are exceedingly rare, and hence few cases have been described. | not china |
Another panel of five small ncRNA pair ratios (different from the first) was able to differentiate LAC from benign disease with an AUC of 82.0%, a sensitivity of 81.1% and a specificity of 78.1% in the training cohort and an AUC of 74.2%, a sensitivity of 70.4% and a specificity of 72.7% in the validation cohort. | china |
Glioblastomas are a kind of cancer with high resistance to treatments, requiring more efficient alternatives of treatment. | not china |
A total of 100 patients (mean [SD] age, 64.4 [10.5] years; 56 men [56.0%]) underwent randomization; 50 were randomly assigned to each group. | china |
In the training cohort, a significant association between shorter OS and high NMPR (p = 0.04) as well as high CRP (p < 0.001), poor tumor differentiation (p = 0.008), advanced T stage (p = 0.006), advanced N stage (p < 0.001) and high CEA (p = 0.007) was revealed. | china |
Furthermore, the in vivo luminescence imaging-guided synergistic PDT and photothermal therapy showed better efficiency in tumor ablation. | china |
With these emerging therapeutic options, it is important to understand the existing data on immune checkpoint inhibitors (ICIs), along with their efficacy and safety for each oncogene-driven lung cancer, to best guide the selection and sequencing of various therapeutic options. | not china |
Cardinal features of CDK13-related disorders are characterized by intellectual disability, developmental delay, dysmorphic facial features, structural heart defect and structural brain abnormality. | china |
Chinese women tend to have small and dense breasts and ultrasound is a common method for breast cancer screening in China. | china |
In this study, we investigated the role of RBCs and hemoglobin (Hb) in the process of tumor progression and therapeutical response. | china |
We aimed to assess the association between intratumoral F. nucleatum and clinico-pathological features, relapse, and overall survival (OS) in two independent cohorts of patients with OSCC, and to explore the interplay with immune-related genes. | not china |
Alpha-eleostearic acid (α-ESA) is a natural and biologically active compound which possesses potent antioxidant and anti-tumor activity. | china |
Thus, the lack of fucose on IgG oligosaccharide improves binding to FcγRIII and antibody-dependent cellular cytotoxicity. | not china |
Five studies were included that compared medicinal cannabis interventions (dronabinol, nabilone and cannabis extract) either with placebo (n = 4) or megestrol acetate (n = 1). | not china |
We also demonstrate that targeting LAT1 may be an efficient broad spectrum adjuvant approach to treat deadly T-cell malignancies as the molecule synergized with rapamycin, dexamethasone, doxorubicin, velcade and l-asparaginase to alter leukemic cell viability. | not china |
Nowadays, pre-chemotherapy education is only given by using print media, which can restrict transferring information to patients with cancer. | not china |
Multivariable logistic regression was used to identify whether group assignment was associated with higher quit rates. | not china |
Integrating the Hi-C, ChIP-seq and RNA-seq data, we observe that transcribed enhancers associate with cancer hallmarks or oncogenes, among which LcsMYC-1 (Lung cancer-specific MYC eRNA-1) potentially supports MYC expression. | china |
This study retrospectively collected the information of 496 adult patients with AML (age ≥14 years at admission) newly diagnosed in the First People's Hospital of Yunnan Province between January 2017 to February 2022, including 115 APL patients. | china |
High frequency mutation and common mutation genes were analyzed based on 1000 cancer related genes. | china |
Out of the fourteen compounds, three compounds 10, 12 and 14 showed higher inhibitory effects on MCF-7 cells. | not china |
Serum CTRP4 levels were detected by an enzyme-linked immunosorbent assay kit. | china |
In several instances, however, the pro-oxidant property of these phytochemicals has been observed with respect to cancer treatment. | not china |
Medullary thyroid carcinoma (MTC) is a malignant neoplasm of parafollicular cells. | not china |
The new fusion form of NTRK rearrangement was detected, which may provide potential treatment options after brigatinib resistance. | china |
To define the recurrence rate of basal cell carcinoma with positive margins after surgery. | not china |
In a multivariate analysis, after adjusting for known prognostic factors, we found no statistical evidence that PBM was related to overall survival, progression-free survival, or local recurrence. | not china |
However, the negative association between the SP activity and anti-tumor immune response was independent of its associations with aneuploidy and TMB. | china |
Associations were analyzed through Cox regression of the UK Biobank data (n = 415,589). | china |