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Chest wall resection is a way to treat solitary BC metastasis, but intraoperative bone defects and local tumor recurrence still affect the life quality of patients. | china |
Presented here are 2 patients of reimplanted mandibles treated by decalcification and lyophilization who were followed up for 8 and 9 years. | not china |
Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). | china |
Although the PI3K/Akt pathway was found to be activated in most of the analyzed tumor samples, the unchanged robust activity of LKB1/AMPK likely prevents (over)activation of mTOR. | not china |
Alectinib by far resulted in fewer adverse events than chemotherapy or crizotinib. | china |
Furthermore, EVO exerted the anticancer effects by suppressing Wnt/β-catenin signal pathway in osteosarcoma cells. | china |
Our findings suggest that while the EGFR amplification may confer a unique molecular profile in primary glioblastoma, pathway analysis reveals upregulation of the EGFR pathway in recurrence, regardless of amplification status. | not china |
Despite of several immunohistochemical, electron microscopic and genetic studies, precise histogenesis of sarcomatoid carcinoma is quite controversial. | not china |
This peptide is able to elicit both CD8+ CTL and T helper cell responses in C57BL/6 mice. | not china |
There are no systematic reviews outlining how nanomedicine and immunotherapy are used in combination to treat cancer. | china |
Therefore, we sought to investigate the potential antiproliferative activity of phosphine-ruthenium-based complexes on human glioblastoma cell lines. | not china |
Use of such templates makes RIS implantation more precise and efficacious and aids preoperative planning, real-time dose optimization, and postoperative planning. | china |
ADM drug resistant cell line T24/ADM was established. | china |
Results. | china |
The aim of this present study was the analysis of the mutations in the D-loop region of mitochondrial DNA, and 4.997 bp deletion during cervical cancer development. | not china |
To evaluate the correlation of circulating C1q tumor necrosis factor-related protein 4 (CTRP4) with coronary artery disease (CAD) in type 2 diabetes mellitus patients. | china |
Taken together, these findings suggest that TNFAIP8 overexpression is a potential biomarker to identify pN0 ESCC patients at higher risk of lymphatic recurrence who may benefit from adjuvant therapy. | china |
miRNA has been linked to cancer processes. | china |
Patients with Child A classification had an average survival of one year longer in the study group (p = 0.035). | not china |
Ultrasound features of breast metastases from lung cancer were irregular (5/7, 71.4%), indistinct (6/7, 85.7%), hypoechoic (7/7, 100.0%), and parallel (6/7, 85.7%) masses without calcification. | china |
One hundred and four were treated with POCRT and 79 with postoperative chemotherapy (POCT) alone. | china |
Mixed-comparison analysis using random-effects models. | china |
Two patients with elevated Ct had no diarrhea. | not china |
The immunohistochemical expression has been compared with the microarray-based mRNA expression of these markers in two prostate carcinoma cell lines (PC-3, DU-145). | not china |
MCF-7 cells responded to OS induction (lipid peroxidation) increasing their antioxidant defenses. | not china |
In the current review, we discuss the structure-function features of non-canonical Hsp70s members and how these features impact their role in cancer development. | not china |
Compared with never cigarette smokers, current cigarette smokers had a RR of 4.49 (95%CI 3.11-6.48) for HNC overall, and 2.11 for OCC, 8.53 for OHPC, and 8.07 for LC. | not china |
All patients underwent MRE at week 0. | not china |
Increasing studies have demonstrated that pyroptosis is closely related to tumor development and antitumor process. | china |
In addition, we will give a brief overview of the limitations of the CRISP/Cas9 gene-editing technique. | not china |
Ve and iAUC60 with all ROIs were not significantly different between responders and nonresponders (P = 0.140-0.968). | china |
Using National Cancer Database (NCDB), 283,347 ES-SCLC cases diagnosed between 2004 and 2017 were screened. | not china |
These results demonstrate that BEN acts as an alkylating agent, demonstrates cross-resistance to CLB and FLU and resistance to cells with a del 17p. | not china |
We conducted a case-control study, including 366 HCC cases and 662 controls without any evidence of tumors, to identify and assess diagnostic and prognostic potential of serum microRNAs for AFB1-related HCC. | china |
The laminin G-like domain in all these proteins binds to a unique glycan structure, so-called laminin-binding glycan, attached to alpha-DG with high affinity. | not china |
This study sought to develop a dual-ligand nanoparticle (NP) system loaded with siRNA to promote targeted delivery and therapeutic efficacy. | china |
Review of clinical and radiographic records of women presenting to a tertiary medical center with the new diagnosis of CNS metastatic disease from breast cancer. | not china |
Bowel obstruction is a rare presentation of urachal adenocarcinoma since the spread of the disease to the viscera occurs much later in the course. | not china |
After accumulating in the tumor tissue via the enhanced permeability and retention (EPR) effect, the nanovesicles could be efficiently diffused in tumor cells by endocytosis and then rapidly release drugs in response to the lysosomal acidic environment, leading to an enhanced tumor-killing effect based on the combination therapy between DOX and the Bcl-2 inhibitor. | china |
Sponsor Study Code: PM1183-B-005-14. | not china |
Must a patient reach a complete molecular response/major molecular response before receiving allo-HSCT? | china |
Both immunohistochemistry evaluation and Western blot analyses demonstrated that SGTA was overexpressed in HCC tissues compared with adjacent nontumorous liver tissues. | china |
More attention should be paid on improving the health of lung cancer patients during the COVID-19 pandemic. | china |
Revealing the sophisticated lung adenocarcinoma structure at three-dimensional (3D) and single-cell level remains a fundamental and critical challenge for the pathological mechanism research of lung adenocarcinoma (LA). | china |
Most of proteins associated with the nature killer cell mediated cytotoxicity pathway were downregulated in the NK-NPC group. | china |
Cancer happening rates in humankind are gradually rising due to a variety of reasons, and sensible detection and management are essential to decrease the disease rates. | not china |
Adjusted Cox-proportional hazards models found API (versus NHW) race to be associated with higher local recurrence [hazard ratio (HzR) 2.45, p = 0.035] and NHB race to be associated with higher distant recurrence (HzR 5.03, p = 0.020) and breast cancer mortality (HzR 3.83, p = 0.046). | not china |
We mainly explored the effects of PIK3R3 and NOTCH2 polymorphisms on liver cancer risk among Chinese people. | china |
In vivo, miR-4651-overexpressing A549 xenografts grew slowly than control A549 xenografts in severe combined immunodeficient mice. | china |
Then, we randomly divided datasets into training and testing sets, performed the LASSO and multicox progression analysis, selected eight genes as prognostic signatures and used the eight genes, calculated the risk score, and then separated the entire cohort into high- and low-risk groups. | china |
For a long time they were misdiagnosed as mucinous cystadenocarcinoma, ductal adenocarcinoma in situ, or chronic pancreatitis. | not china |
Further, we found that the recruitment of Human antigen R (HuR) to m6A-modified RNA is essential for SOX2 mRNA stabilization by METTL3. | not china |
In this study, we highlighted the relevance of identifying the drug-regulated circ/linRNAs according to their oncogenic or anticancer role. | not china |
A total of 85 (44.50%) gastric cancer patients had been proven to have micro lymph node metastasis. | china |
Our findings thus offer theoretical support with bioinformatics analyses to the study of ECM and adhesion proteins in ccRCC, which may provide a new perspective for the clinical management of ccRCC. | china |
The expression of Ln-γ2 would be useful for risk assessment of lymph node metastasis and poor prognosis in routine practice of cSCC. | not china |
LRP11 was a potential oncogene and prognostic marker in cervical cancer and pan-cancer. | china |
There was consensus on 23 QIs out of total of 662. | not china |
A total of 200 AG patients from a prospective cohort (67% female, median age 55 years) with a follow up of 7.5 (range: 4-23.4) years were included. | not china |
Individuals with the ERCC2 A/A genotype were likely to have a lower risk of death from oseosarcoma, and the adjusted HR was 0.32 (0.13-0.95). | china |
Recent molecular studies in pancreatic endocrine tumors showed activation of the same pathway, which points toward a common molecular pathway between these two entities. | not china |
Faecal microbiome transplantation from Satb2 IEC-KO mice aggravated colitis and M1 macrophages infiltration. | china |
Many VUS undergo category reclassifications over time (from months to years after initial classification) as more information is known about normal human genomic diversity, especially among underrepresented minority populations. | not china |
This necessitates exploration of targeted chemotherapeutics. | not china |
Compared with conventional pancreatic resection, enucleation had a shorter duration of surgery (P < 0.001), less blood loss (P < 0.001), lower rate of exocrine insufficiency (P = 0.033) and comparable morbidity (P = 1), with no increased risk of tumor recurrence (P = 1). | china |
Flow cytometry measurements assessed cell cycle parameters and apoptosis, while levels of c-Myc together with key transcriptional targets were determined using qPCR and Western blotting. | china |
There were 102 patients with HPV-OPSCC treated between July 2009 and December 2014 at the Royal Adelaide Hospital. | not china |
must be taken into account for the actual treatment choice. | not china |
Future mind-body intervention studies should incorporate multimodal therapy focused on improving physical symptoms in this population. | not china |
These results may provide more data about the vital role of NETs in bladder cancer. | china |
Erbin expression is significantly elevated in human hepatocellular carcinoma (HCC) tissue. | china |
The crizotinib trough concentration on day 14 ranged from 243.5 to 847.8 ng/mL, and all of the patients achieved stable disease based on assessment of the tumor response on day 28. | not china |
The prognostic role of pathologic fracture in osteosarcoma has not been settled down, as previous researches have reached contradictory results. | china |
Key limitations of the BMM data item were that it did not include any details regarding testing technique or assay type and could not distinguish between a lack of testing and a lack of cancer registry reporting of testing results. | not china |
We found that high IDH2 expression was associated with poor survival in lung cancer patients undergoing chemotherapy. | china |
As a result, we found that new ALL cases increased significantly by 1.29% worldwide, and the age-standardized incidence rate increased by 1.61% annually. | china |
Over-expression of hMSH2 in cell lines resulted in a significant reduction in growth and induction of apoptosis. | china |
Due to abnormal metabolic properties of tumor cells, tumor microenvironment usually contains abundant amount of CO2. | china |
Our Perspective highlights evidence from basic and translational research indicating that including genetic sex considerations in treatments for patients with cancer will improve outcomes. | not china |
Self-assembling surfactant nanomicelles have been chosen as the carrier to drive the hybrid 1 into the skin; the in vitro permeation through and penetration into pig ear skin have been evaluated. | not china |
TMEFF2, SMOC-2 expression was correlated with the presence of lymph node metastases (p = 0.023), distant metastasis (p = 0.039) recurrence of the tumor after successful therapy, overall survival, and disease-free survival (p < 0.001). | not china |
In the present study, we developed an effective signature in cervical cancer for prognosis prediction and patients' stratification in OS and DFS. | china |
Spread through airspaces (STAS) is a form of tumour invasion involving tumour cells spreading through the airspaces, which has been highly researched in recent years. | not china |
We tested the normal tissue complication probability (NTCP) model recommended in the recent QUANTEC review (quantitative analysis of normal tissue effects in the clinic). | not china |
Our findings indicate that patient navigation did not significantly impact chance of diagnosis by 60 or 90 days from abnormal finding. | not china |
AHR and its abnormal expression may play an important role in multiple stages of breast cancer progression. | china |
The DNA was extracted from formalin-fixed paraffin-embedded (FFPE) samples from the primary tumors of these patients. | china |
Prevalence of hepatitis C virus (HCV) infections in Egypt is among the highest in the world. | not china |
N6-methyladenosine is the most abundant RNA modification, which plays a prominent role in various biology processes, including tumorigenesis and immune regulation. | china |
The current study aimed to find an efficient shielding material for fast neutrons. | not china |
Consequently, the "Adams predictor-corrector" method is used. | not china |
The PDHB expression was categorized according to the local control of the disease with a recursive partitioning analysis. | not china |
Here, we constructed a TME-related gene signature that is prognosis of disease survival and may predict response to immunotherapy in colon cancer. | china |
Supplementary data are available at Bioinformatics online. | china |
Bioinformatic approaches, including expression quantitative trait loci, binding motif and transcriptome analyses, and biological experiments were done to fine-map and explore the functional relevance of genome-wide association loci to the development of NKTCL. | china |
Certain rare germline alterations were noted, such as those noted in the following genes: FANCD2, CDH1, and FLCN. | china |
However, there is greater variation in cystoscopy rates among women with symptoms of bladder cancer. | not china |
SR increased the migration and invasion ability of HCC cells by inhibiting AMPK/mTOR signaling, which was enhanced by the AMPK inhibitor compound C and blocked by the AMPK activator GSK-621. | china |
Six cases (23.1%) were sentinel node (SN) metastasis-positive. | not china |
Immunohistochemistry was used to detect the expression of vascular endothelial growth factor (VEGF), CD31 and CD34 in CDK11 positive patient breast cancer tissues. | china |