text
stringlengths 2
1.34k
| label
stringclasses 2
values |
|---|---|
In the current study, an adult-stage zebrafish HCC model was used to examine the synergistic effects of twist1a and xmrk, a well characterized oncogene, during HCC metastasis. | not china |
Limited knowledge is available on dietary patterns and bladder cancer risk. | not china |
We also detected that this process was related to the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases 4 (PFKFB4) by PFKFB4 knockdown experiment. | china |
Metastasis to spinal cord for follicular dendritic cell tumor is very rare, and to the best of our knowledge, no such case has been previously reported in the scientific literature so far. | not china |
One hundred and sixty-three (53.8%) patients achieved no gross residual disease (NGRD), and 69 (22.8%) had residual disease < 1 cm, whereas 71 (23.4%) had residual disease ≥ 1cm. | china |
We hypothesized that the combination of several functional parameters increased the predictive power. | not china |
We have identified significant deficits in the care of patients with ACC in Germany. | not china |
T1 mapping with syngo MapIt was obtained on a 1.5 T scanner. | china |
The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice. | china |
Gastric cancer (GC) is one of the most common malignancies in digestive system. | china |
We report the case of a 68-year-old, healthy male presenting with elevated PSA and lower urinary tract symptoms found to have a PI-RADS 3 lesion. | not china |
Serum α-fetoprotein (AFP) was elevated in 1 patient (case 3, 8338 ng/mL) and not measured in the other two. | not china |
However, the functions of circRNAs in nasopharyngeal carcinoma (NPC) are unclear. | china |
All patients had non-seminoma. | not china |
Using 15 cases diagnosed with GISTs, we searched for novel indicator genes by microarray analyses using an Oligo GEArray(R) PI3K-AKT Signaling Pathway Microarray Kit. | not china |
In most advanced cancers, telomerase is reactivated and serves to maintain telomere length and emerging data have also documented the capacity of telomerase to directly regulate cancer-promoting pathways. | not china |
The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ECE were 54%, 94%, 95%, 48% on mpMRI, 78%, 94%, 97%, 67% on PET/CT and 83%, 88%, 94%, 71% on com-MRI/PET. | china |
Performing a Propensity Score Matching based on gender and tumor stage, the effect of treatment on seropositivity was analyzed through a regression logistic model and the ICIs treatment resulted to be the only protective factor significantly (p = 0.03) associated with positivity (odds ratio-OR: 0.41; 95% confidence interval-CI 0.18-0.91). | not china |
A rapid review (a streamlined evidence synthesis) was performed to summarise data on tomosynthesis screening in women with heterogeneously dense or extremely dense breasts, with the aim of estimating incremental (additional) BC detection attributed to tomosynthesis in comparison with standard 2D-mammography. | not china |
In addition, the combination of mSEPT9 and CEA had a higher specificity than CEA alone (81.70% Vs 75.00%). | china |
Human papillomavirus (HPV) is the cause of a distinct subset of oropharyngeal cancer rising in incidence in the United States and other developed countries. | not china |
Validated questionnaires were used to assess global quality of life and cognitive functioning (EORTC-QLQ-C30), fatigue (EORTC-QLQ-C30 and Checklist Individual Strength, CIS), and depression and anxiety (Hospital Anxiety and Depression Scale). | not china |
In cell models, CRIP1 was overexpressed in serous epithelial ovarian cancer. | china |
The biodistribution studies indicate that the radiotracer (99m)Tc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent. | china |
While HER2 gene detection in cytological specimens using fluorescence in situ hybridization (FISH) has been reported, the appropriate criteria for such specimens remain controversial. | not china |
M6A-related lncRNAs associated with GC were identified by constructing a co-expression network, and the gene pairs differentially expressed in GC were selected using univariate analysis. | china |
The Cochrane Collaboration's Review Manager 5.4 software was applied to analyze data. | china |
Histologic and prognostic effects of NAC were assessed. | china |
Diagnosis of the early-invasive oral squamous cell carcinoma (OSCC) can be challenged in biopsies, and immunohistochemistry is commonly used in such settings. | china |
These mutations may serve as critical predictive biomarkers in patients with non-small cell lung cancer (NSCLC). | china |
We report a case of a pulmonary glomus tumor that was observed for a long period. | not china |
Gastric cancer was diagnosed in four patients at a median follow up of 7.2 years (crude incidence 2%). | not china |
Bacteroides were detected by fluorescence in situ hybridisation [FISH] on colonic tissue. | china |
Results The overall incidence of cholangiocarcinoma from 2001 to 2015 was 1.26 per 100,000 people per year. | not china |
In this study, breast cancer cells (MCF-7 and MDA-MB-231) were used to study the effect of IL-1β on the changes that can promote VM. | china |
Patients with stage II CC should be considered as stage ⅢB if the ELN count is insufficient. | china |
Patients were divided into standard-dose and low-dose groups according to the epirubicin dose. | china |
Moreover, overexpression of miR-146a enhanced the growth of an HTLV-1-infected T-cell line. | not china |
Self-reported severe late symptoms were more prevalent in survivors with short education and in those living alone, suggesting differences in perception of late symptoms between social groups. | not china |
Epistasis analysis showed that KLF17 overexpression overcomes increased cell invasion by DJ-1, suggesting that KLF17 might be one of the downstream signalling molecules of DJ-1. | not china |
Among the patients treated with neoadjuvant chemotherapy, those with advanced disease had a better prognosis in the GC-TLS high-density group than did those in the GC-TLS low-density group. | not china |
Clonal cell lines were isolated from primary transgenic polyomavirus middle T (PyVmT) luminal tumors. | not china |
This review outlines the pertinent research in the field over the last year and discusses the clinical implications. | not china |
Environmental and genetic factors have been correlated with an increased risk of developing brain tumours. | not china |
In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR-3200-5p/ATF4 axis to modulate the development of hepatocellular carcinoma. | china |
AR inhibition led to changes in the levels of glycolysis and tricarboxylic acid (TCA) cycle pathway intermediates. | not china |
qRT-PCR and Chromogenic in Situ Hybridization (CISH) was conducted to assess the expression of miR-608 in paired BCa tissues and adjacent non-tumor bladder urothelial tissues. | china |
Biomarker expression in tissue, serum, plasma, or urine can detect tumor in very early stages of its development and monitor the cancer progression and also the effect of therapeutic interventions. | not china |
However, SUVmax value was not associated with OS (P = 0.895) and PFS (P = 0.686). | china |
Using the CIBERSORT algorithm, the results revealed that Macrophages M0, Macrophages M2, and T cells CD4 memory resting accounted for a large proportion of immune cell infiltration. | china |
Following univariate Cox analysis of differentially expressed genes between subtypes, we established a prognostic model (PRGs-score, PRGS) by LASSO Cox analysis. | china |
Purpose: To conduct a systematic review and network meta-analysis (NMA) to compare the efficacy of currently available combination therapies in patients with metastatic hormone-sensitive prostate cancer (mHSPC). | china |
Aberrant expression of ARE-binding proteins (ARE-BPs) plays an important role in several diseases, including cancer. | china |
All findings were confirmed by histopathology and/or at least 3 months follow-up (F-18-FDG PET/CT, CT, or magnetic resonance imaging). | not china |
N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNAs, which plays an important role in regulating multiple biological processes. | china |
Mechanistically, by using RNA-sequencing, bioinformatics analysis, dual-luciferase reporter assay, and western blotting, we determined that circ_0008285 suppressed the PI3K/AKT pathway via the miR-382-5p/PTEN axis. | china |
We reviewed the available data on biomarkers of bladder SCC and provide suggestions on how these may influence therapeutic testing and clinical trials in the future. | not china |
Furthermore, ectopic expression of UL136 inhibits tumorigenicity in an animal model. | china |
To achieve our goal, we treated Swiss albino mice with Apigenin (50 mg/kg bw) alone or in combination with Sorafenib (40 mg/kg bw). | not china |
Besides, patients with high expression of WDR5 presented a poorer overall survival. | china |
Prevalence of LSS in women with BC was 22.8% with confidence interval 14.6-39.94. | not china |
It is verified that failure in cancer therapy by conventional chemotherapeutic agents arise from cancer heterogeneity. | not china |
Sixty-seven cases had renal clear cell carcinoma, six papillary renal cell carcinoma, and one renal collecting duct carcinoma. | china |
Thirty-four of them were treated with a regimen of pemetrexed plus oxaliplatin (PEMOX). | china |
A new metabolic pathway has been proposed here in HCC and colon cancer, SPL converts S1P to glyceroLPLs, mainly to LPI and LPG, and facilitates cancer development. | not china |
Furthermore, we identified miR-29c as a negative regulator of JARID1B in GC. | china |
The radiomics signature showed a good ability to discriminate between invasive adenocarcinomas and non-invasive lesions with an accuracy of 86.3%, 90.8%, 84.0% and 88.1%, respectively, in the primary and validation cohorts. | china |
Deregulated miRNAs were associated with breast cancer and targeted genes involved in MG development, growth, and cancer. | not china |
Tumor cells were shown to express aberrant glycosylation patterns and neutrophils are equipped with receptors capable of recognizing such glycosylations. | not china |
Importantly, almost all these APL-like AML patients show resistance to all-trans retinoic acid (ATRA), and no effective treatment is recommended for them. | china |
Ultimately, there are pitfalls to avoid to correctly distinguish this benign myoepithelial lesion from more biologically aggressive neoplasia. | not china |
The pairs for small RMSE had lower b-values as the noise level increased. | not china |
HAX-1 is an anti-apoptotic factor and overexpressed in many types of cancers. | china |
Semi-structured interviews were conducted and data were analysed using a constant comparative methodology. | not china |
ANRIL was overexpressed in EOC tissues relative to normal controls. | china |
Hematopoietic stem cells (HSCs) are rare, self-renewing cells that perch on top of the hematopoietic tree. | not china |
To evaluate the risk of secondary cancer especially treatment-related secondary cancer in patients with malignant meningiomas by using data from surveillance, epidemiology and end results (SEER) database. | not china |
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis due to high lymphatic metastatic recurrence rates after Ivor Lewis esophagectomy. | china |
Four metabolic subtypes (Cholesterogenic, Glycolytic, Mixed and Quiescent) of gastric cancer were identified, and patients with cholesterogenic tumors had the longest disease-specific survival (DSS). | china |
Radiation therapy is one of the cornerstones of cancer treatment. | not china |
In our proposed SAP, the peptide is represented by 400D features or 400D features with g-gap dipeptide features, and then the unrelated features are pruned using the maximum relevance-maximum distance method. | china |
In glomerular miniorgan culture, activation of β-catenin by Wnt3a repressed WT1 and its target gene expression. | china |
ZFP91 may serve as a driver gene to activate HIF-1α transcription in the development of cancer. | china |
Here, using multiparametric flow cytometry, the relevance of ICOS and PD-1 to angioimmunoblastic T-cell lymphoma diagnosis was evaluated in lymph node (n=15) as well as in peripheral blood (n=13) among a series of 28 angioimmunoblastic T-cell lymphoma cases, in addition to the CD10 expression (available in 26 lymph node and 15 peripheral blood specimens). | not china |
A positive correlation between HBx protein level and AIB1 protein level was established in HCC specimens. | china |
YAP1-silencing led to the concomitant decreased expression of major oncogenic pathways including Kras, mTOR, β-catenin, and M2-promoting IL-4 and tumor-promoting IL-6 cytokines. | not china |
They have achieved better results in prolonging the progression free survival and improving quality of life in comparison to chemotherapy. | china |
Besides the conventional chemotherapeutics, new cancer drugs were developed in the last decade with the goal to specifically inhibit selected molecular targets such as growth factor receptors or intracellular tyrosine kinases in cancer cells. | not china |
No specific genes were overexpressed in the >1% Ki-67 group. | not china |
Rg3 is an attractive and efficient agent that has oncotherapeutic effects and requires further investigation. | china |
Altered expressions of immune-related genes were observed in both groups. | china |
In conclusion, CDK5 positively regulates Notch1 function via phosphorylation, which in turn promotes cell proliferation and migration. | china |
An aggressive treatment approach using a combination of surgery, chemotherapy and radiotherapy is recommended for a reasonable survival in these tumors. | not china |
Scutellarin, a flavonoid compound in Scutellaria barbata, has been reported to suppress CRC, with the action mechanism elusive. | china |
I propose that MTA1 is a stress response protein that is upregulated in various stress-related situations such as heat shock, hypoxia, and ironic radiation. | china |
The blockade of IL-17 in STAT1-/- mice reduced the accumulation of CD11b+Ly6ClowLy6G+ cells resembling granulocytic myeloid-derived suppressor cells (MDSCs) in both spleen and circulation. | not china |
ΔCEA was significantly associated with early recurrence at 6 months, 1 year and 2 years post-operatively, only when disease recurrence was macroscopically established. | not china |
This selectivity was recognized to be an apoptosis-dependent mechanism proven via cell cycle arrest in sub-G1 phase and fragmentation of genomic DNA. | not china |
The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR. | china |
This study uncovers significant organ and cellular-level functional deficits in cachectic hearts outside of the catabolic in vivo environment, which is explained in part by impaired calcium cycling. | not china |