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The weakness of our cohort size notwithstanding, vitamins levels in serum and genetic polymorphisms in the hOGG1 or GST genes do not appear to be important modulators of 8-oxodG levels. | not china |
These suggested miR-522-accelerated G1/S transition. | china |
Postoperative irradiation (45 Gy in 25 fractions over 5 wk followed by boost up to 55 Gy) was subsequently delivered. | not china |
This study reveals new PKs associated with CCA and suggests PRKD kinases as novel treatment targets for CCA. | china |
In patients treated with immunotherapy, samples with high-risk scores had higher expression of immune checkpoint genes and better immunotherapeutic efficacy than those with low-risk scores. | china |
Standard dosing of trastuzumab is currently extrapolated from breast cancer data: a 3-week schedule (8 mg/kg load, 6 mg/kg q 3 weeks) or a weekly schedule (4 mg/kg load, 2 mg/kg q week). | not china |
Finally, we performed univariable and multivariable time-to-event analyses, adjusting for age, sex, body mass index, comorbidities, performance status, extent of surgical resection, extent of tumor at diagnosis, and MGMT methylation. | not china |
An enzyme-linked immunosorbent assay (ELISA) was developed in-house to detect plasma IgG antibodies to CD25-derived linear peptide antigens in 122 patients with HCC and 121 control subjects. | china |
Moreover, knockdown of GGN inhibited the expression of p-Akt in CRC cells. | china |
The annually increasing incidence of endometrial cancer in younger women has created a growing demand for fertility preservation. | china |
After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary odds ratios became 0.82 (95% CI = 0.71 to 0.94; P heterogeneity = .02) for premenopausal and 0.85 (95% CI = 0.75 to 0.96; P heterogeneity < .01) for postmenopausal women. | not china |
Finally, the performance of the PNN/GRNN model is compared with that of other classification models. | not china |
Full transcriptome annotation, including protein-coding and non-coding RNAs, greatly improves the specificity of lncRNA expression quantification. | not china |
The prevalence of EGFR mutations was significantly higher in the high-nickel subgroup than in the low-nickel subgroup. | not china |
In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10 frequently co-occur with oncogenic EGFR mutations. | china |
CNS involvement increased the risk for all CNS toxicities, seizures, and PRES in univariate analysis and, after adjusting for induction therapy, for seizures (hazard ratio [HR] = 3.33; 95% confidence interval [CI]: 1.26-8.82; p = 0.016) and PRES (HR = 4.85; 95% CI: 1.71-13.75; p = 0.003). | not china |
Tissue samples were investigated by immunohistochemical staining using antibodies for Cx26 and P53. | not china |
In a similar manner, 4β-OHC/C in end-of-life female patients was significantly higher compared to young and elderly female controls, p < 0.0001 and p < 0.001, respectively. | not china |
Our findings indicate that selective blockade of TNFRI, leaving the antiinflammatory effects of TNFRII unaltered instead of unselectively blocking TNF, might be advantageous in patients with RA. | not china |
Statistical analysis was performed by using the software STATA 11.0. | china |
Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. | not china |
The fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System (CNS) now includes mesenchymal tumors that occur uniquely or frequently in the CNS. | not china |
UPP1 overexpression was significantly correlated with lymph node metastasis, tumour stage and tumour size. | china |
The prognostic value of POLE/POLD1 mutations was also explored in 2,487 ICI-treated patients from published studies. | china |
This study was limited by its retrospective nature and potential for selection bias. | not china |
[BMB Reports 2019; 52(5): 312-317]. | china |
For the orthotopic transplanted tumor experiments, the JPFR extract could inhibit the growth of orthotopic transplanted tumors and downregulate the expression of c-Myc and Cyclin D1 in a dose-dependent manner. | china |
Decline in sexual functioning at an early adult age can be regarded as 1 of the late effects of childhood cancer. | not china |
The Sensitivity, specificity, PPV and NPV of SVI were 67%, 93%, 72%, 91% on mpMRI, 75%, 95%, 82%, 93% on PET/CT and 75%, 88%, 64%, 93% on com-MRI/PET. | china |
If correct, this could have a significant impact on oncologic drug development. | not china |
In subgroup analysis based on cancer type, associations were found in head/neck and breast cancer under the recessive model, and also in breast cancer under the dominant model. | china |
In M4E cells stimulated with different concentrations of H2O2, the clonality and Ki-67 positive cell ratio were detected. | china |
Our data therefore define the integrated duality of Nur77 and TGFβ signaling in regulating ID1 expression and provide mechanistic insights into the paradoxical roles of TGFβ and Nur77 in colon cancer progression. | china |
Tumor-infiltrating CD8+ T cells are frequently associated with favorable clinical outcome in a remarkably large spectrum of cancers. | not china |
The survival data were obtained from the CHOICE-01 clinical trial. | china |
A model library was generated and with the extracted features from modeled spectra, classification of normal and NMSC conditions were tested using the [Formula: see text]-nearest neighbor (KNN) classifier. | not china |
By calculating the 4 topological features (degree, betweenness, closeness, and coreness) of each node in the network, we identified the candidate Qingdai targets according to their network topological importance. | china |
Percentage resection was measured by weight. | not china |
In the current study, socioeconomic status and features of physical health rather than tumor characteristics were associated with symptoms of depression among long-term colorectal cancer survivors. | not china |
Contrast-enhanced ultrasound guided radiofrequency ablations is a promising alternative for reninoma treatment with comparable safety and efficacy with surgery, and has advantages especially in small or deep lesions. | china |
A preoperative HE4 evaluation could help stratify patients with deep invasion and/or metastatic disease and is correlated with other relevant prognostic factors to be considered to tailor an adequate surgical strategy. | not china |
Our case presentation is of a 68-year-old female who presented with abdominal pain. | not china |
Gene analysis is currently only useful for diagnostic assessment and predicting therapeutic effects. | not china |
A comprehensive analysis of the efficacy, safety, and cost-effectiveness of aflibercept in mCRC treatment is necessary. | china |
Although mercaptopurine-dose reduction reduces toxicity risk without compromising relapse rate in patients with TPMT deficiency, dosing recommendations for those with moderately reduced activity (intermediate metabolizer (IM)) are less clear and their clinical impacts have yet to be established. | not china |
Thus, our findings provide mechanistic explanation for the protumorigenic potentials of FTY720 and suggest that targeting S1pr3 simultaneously may be beneficial for the patients receiving FTY720 treatment. | china |
Our findings indicate that GS upregulation-induced excessive of Gln in adipocytes via altered histone methylation is potential mediator of resistance to 5FU chemotherapy in patients with CRC-PC. | china |
In BL, TCF3 is constitutively active, and/or expression of its transcriptional targets are altered as a result of BL-associated mutations. | not china |
A total of 251 patients with the International Federation of Gynecology and Obstetrics (FIGO) Stage IA1-IIA2 cervical cancer who underwent surgery without any preoperative treatment were enrolled in this study. | china |
Atractylodin exerts significant cytotoxic activity against CL-6 cells which may be linked to its suppressive effect on HO-1 production, STAT1/3 phosphorylation and expression of key NF-κB proteins. | not china |
Selected essential and toxic elements (Fe, Zn, Cu, Mn, Ni, Cr, Cd and Pb) were analysed in the blood & scalp hair of lymphoma patients (n = 59 & 58, respectively) and controls (n = 61 & 60, respectively) by atomic absorption spectrometry. | not china |
We systematically searched for relevant literature in PubMed, EMBASE, CNKI, and Chinese Wanfang databases. | china |
Lower mean ADC values are associated with shorter patient survival in skull base chordomas after GKRS. | not china |
Finally, a total of 8 articles met the inclusion/exclusion criteria, involving 1,677 subjects. | china |
Despite the success of immune checkpoint inhibitors that target cytotoxic lymphocyte antigen-4 (CTLA-4) and programmed-cell-death-1 (PD-1) in the treatment of metastatic melanoma, there is still great need to develop robust options for patients who are refractory to first line immunotherapy. | not china |
Metastases are the most devastating and lethal clinical situation in urothelial carcinoma. | not china |
This is the first case of pancreatic metastasis from adamantinoma, a rare, low grade and slow growing tumor which is frequently localized in long bones. | not china |
In addition, high Ln-γ2 expression at the invasive front was also associated with lymphatic invasion, lymph node metastasis, and poor prognosis (death or recurrence), as in TB. | not china |
PRGS has promising application in forecasting the prognosis of HCC patients, and its relationship with the immune microenvironment provides a basis for the subsequent treatment and research of HCC. | china |
Overall, our research provides a comprehensive insight into the application of deglycosylated PD-L1 detection, which expands the clinical significance of this established strategy in LuCa. | china |
Tumor-to-tumor metastasis is a fairly rare phenomenon. | china |
Although fine needle aspiration cytology (FNAC) often correctly diagnoses these tumors, they are occasionally misdiagnosed as malignant. | not china |
The bioinformatics and luciferase report data validated that both miR-214-3p and YAP1 were hsa_circ_0014784 binding partners. | china |
Flow cytometry of annexin V/propidium iodide double-dyeing apoptosis and caspase-3 fluorescence staining showed that this treatment method could turn transfected OCM-1 cells into apoptosis and necrosis by the effects of the gene expression. | china |
In this work, we propose a hypoxia-responsive nanomicellar drug delivery system that aiming hypoxia TME of pancreatic cancer. | china |
Angiogenesis, the formation of new blood vessels from pre-existing vessels, is essential for the growth and metastasis of tumors. | not china |
With newer techniques (intensity-modulated/volumetric-arc therapy (IMRT/VMAT)), the dose to non-involved adjacent LN decreases, which raises the question whether FDG-PET-CT-delineation is still safe. | not china |
We report that Abelson interactor 2 (ABI2) is a novel therapeutic target of HCC CSCs. | china |
We included 98 patients in the study group and 101 patients in the control group. | not china |
There was initial evidence that hypoxia regulates the function of both amino acid transporters in breast cancer. | not china |
FIRE-3 was a randomised phase 3 trial comparing FOLFIRI plus cetuximab with FOLFIRI plus bevacizumab in the first-line treatment of patients with KRAS exon 2 wild-type metastatic colorectal cancer. | not china |
Recently, a possible relation between HPV and oral squamous cell carcinoma (OSCC) has also been noticed. | china |
Here, p53 mutant/Wild-type cells were employed to study the toxicity of DNC using MTT assay, Flow cytometry and Annexin-V, Real-time PCR and Western blot were used to analyze p53, BAX, Bcl-2, p21 and Noxa changes after treatment. | not china |
BS-BM could better predict survival of patients before intracranial surgery compared with other PIs. | china |
Moreover, circVPS35L was highly stable in peripheral blood when exposed to undesirable conditions. | china |
The calculated pharmacokinetic parameters from the subjects in the multiple- and single-dose (1.5 mg·m(-2)) groups had no significant differences. | china |
Immunofluorescence staining and co-immunoprecipitation analysis further revealed the interaction between ZO-1 and β-catenin and the repressed role of ZO-1 in β-catenin nuclear accumulation. | china |
The obtained results were compared to official and reported method showing that there were no significant differences. | not china |
We found that matrine induced cell apoptosis by down-regulation of the ratio of BCL-2/BID and increasing activation of caspase-9. | china |
DNA damage and repair associated proteins expression in AGS and SNU-1 cells were measured by Western blotting. | not china |
In addition to replicating known susceptibility loci (e.g., ESR1, FGFR2, and TOX3), we identify two novel missense variants in C21orf58 (rs13047478, Pmeta = 4.52 × 10-8) and ZNF526 (rs3810151, Pmeta = 7.60 × 10-9) and one new noncoding variant at 7q21.11 (P < 5 × 10-8). | china |
The underlying mechanism of capsaicin's antitumor potency was mainly attributed to the stabilization and activation of p53. | china |
The primary objective of cancer treatment strategies has traditionally focused on preventing the occurrence of metastasis. | not china |
Based on their expression heterogeneity, ccRCC tumors were categorized into CIN25-C1 (low) and C2 (high) subtypes. | china |
Sorafenib appears to reduce sensitivity to 5-FU through down regulation of cyclin D1 expression by inhibiting RAF/MEK/ERK and STAT3 signaling, resulting in G1-phase arrest and reduction of the S-phase cell subpopulation when 5-FU is administrated after sorafenib, in which situation, combination treatment of the two agents results in antagonism; on the other hand, when sorafenib is administrated afterward, it can continue to work since it is not cell cycle specific, as a result, combination treatment of the two agents shows an additive-to-synergistic effect. | china |
The mdivi-1 group showed an inhibitory effect on the proliferation and migration of BEL-7402 cells at 50 μmol/L. | china |
In this report, we examined the role of miRs as biomarkers in CRC through a review of meta-analyses and large-scale analyses having strong statistical confidence in the study outcomes. | not china |
However, the role of HDAC3 and the antitumor activity of its inhibitor MI192 are not known in cholangiocarcinoma (CCA). | china |
11a displayed strong inhibition against the PARP-1 enzyme with an IC50 of 8.6±0.6 nM and excellent potentiation of temozolomide cytotoxicity in cancer cell lines SW-620, MDA-MB-468 and A549 by 4.0, 3.0 and 7.7 times, respectively. | china |
This work investigates the impact of PET and MRI threshold-based tumor segmentation on TRT dosimetry in patients with primary and metastatic brain tumors. | not china |
Luciferase reporter assay was performed to verify the targets of ACTA2-AS1 and miR-4428. | china |
FT-IR spectra of glass samples show the presence of all structural units characteristic to P2O5 in different rates and directly depending on the depolymerization process. | not china |
The YAP1/TEAD1 protein complex had the capability to influence downstream cytoskeletal proteins by regulating SRC transcription; therefore, it converts NF to CAF, and CAF can significantly promote tumour growth and metastasis. | china |
To increase antibody-dependent cellular cytotoxicity, a strategy improving the affinity between the Fc portion of the antibody and FcγRIIIa expressed by effector cells has been recently developed. | not china |
C21orf58 and ZNF526 possessed functional roles in the control of breast cancer cell growth, and the two coding variants were found to be the eQTL for several nearby genes. | china |
Cell growth and metastasis were promoted in the hypoxic CRC cells. | china |
Retrospective, nonrandomized small sample size cohort. | not china |
a multicenter, open-label study. | not china |
We have proposed a molecular test based on the expression level of a series of 19 genes, capable of discriminating malignant from benign tumors [15]. | not china |
The aggregate behaviors as represented by the HLS were associated with the SCES (r = 0.19, p-value = 0.03). | not china |