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After 53 months median follow-up time, the 5-year progression-free survival (PFS) rates in CT + RT group vs. CT group were 93.3% vs. 92.5% (P = 0.896), the 5-year overall survival (OS) rates were 96.7% vs. 94.4% (P = 0.649). | china |
Cancer patient data were used to verify the correlation between drug response and MYC and/or TYMS mRNA levels. | china |
HNOT/ALG3 encodes two translated transcripts encoding precursor proteins differing in their N-terminus and showing 33% identity with the yeast asparagine-linked glycosylation 3 (ALG3) protein. | not china |
AR-V7 lacks a ligand-binding domain and is linked to poor prognosis. | not china |
Clonal selection leads to the development of T-cell lymphomas with stereotypic karyotypes in which chromosome 15, containing the Myc oncogene, is gained with high prevalence. | not china |
If irAEs are severe or require systemic steroids, cancer therapy is often held or discontinued. | not china |
Compared with CEUS, (18) F-FDG-PET/CT has higher sensitivity and accuracy in detecting the local recurrence of HCC after hepatectomy and/or RFA. | china |
The TCscore effectively distinguished between populations with different responses to chemotherapeutics or immunotherapy and overall survival. | china |
In the Original Report that accompanies this article, the authors provide a post hoc analysis of ARASENS (ADT plus docetaxel, with or without darolutamide), identifying the subpopulations of patients with mHSPC who might benefit most from a triplet regimen. | not china |
For the OS and DFS prediction in the testing cohort, RS showed a Harrell's concordance index of higher than 0.700, while the areas under the curve (AUC) achieved up to 0.800 in the same cohort. | china |
Analysis of the breakpoint sequences showed that some of them were clustered within a few hundred base-pairs suggesting, even if we failed to identify any clear recombination prone sequences, that in these deletions the rearrangement results from non-random mechanisms. | not china |
Transwell experiments and scratch tests were used to determine cell migration. | china |
In this retrospective cohort study, the clinical and physiological outcomes were compared between 25 patients who underwent this procedure and 21 patients who underwent JI from 2001 to 2005. | not china |
No adverse events such as cardiac arrhythmia and lidocaine toxicity occurred in both groups during the perioperative period. | china |
The data should provide clinicians and researchers insight into future directions relative to the advancement of HCC management. | china |
A total of 1032 patients with early HER2-positive breast cancer met the enrollment criteria and were included in this study. | china |
This is an Institutional Review Board-approved retrospective case series of patients with uveitis secondary to immunotherapy or targeted therapy managed with local treatment, and focused literature review. | not china |
Moreover, multivariate analysis revealed that high PARP-1 expression was an independent risk factor for both OS and RFS. | not china |
We conducted exact logistic regression using the 50th percentile level among exposed controls to create low and high exposure categories. | not china |
Pulmonary nodules in 346 healthy subjects (male: female = 221:125, mean age 51 years) from a lung cancer screening program conducted from March to November 2017 were screened using a DL-CAD system and double reading independently, and their performance in nodule detection and characterization were evaluated. | china |
The rate of tumor induction by ultrasound-guided implantation was comparable to that of laparotomy (55/91, 60.4% vs. 39/52, 75%) and no significant difference in sizes of tumor was noted between the two groups. | not china |
PRDX2 depletion led to reduced p-AKT expression and PI3K/AKT pathway inhibition promoted cell apoptosis in HT29 cell line. | china |
Patients with active TB infection were treated with concurrent anti-TB and anti-PD-1 treatments, and the remaining received either mono-immunotherapy or combined immunotherapy. | china |
This was mainly ascribed to the synergism of PTX and 5-FU and the reverse of MDR by the inhibition of ATPase activity by VE and TPGS. | not china |
In this study, we examined whether drugs that reverse epigenetic modifications will enhance ERβ expression and augment ERβ agonist-mediated tumor suppression. | not china |
VSLI exhibits a lower clearance and a higher AUC compared with conventional VCR. | china |
Because few studies have focused on the correlation between computed tomography (CT) signs and tumor grade in pseudomyxoma peritonei (PMP), we evaluated predictive value of abdominal enhanced CT in identifying high- vs. low-grade cases. | china |
Employing LASSO-COX regression analysis, a risk-prognostic model was formulated, centered on seven ERGs. | china |
Peroxidative damage caused by rapid proliferation coupled with an increased redox buffering capacity and the antioxidant pool is a major mode of redox homeostasis reprogramming. | china |
The Ovid, PubMed, and Google Scholar databases from January 1990 to October 2010 were searched. | china |
Thus, he was diagnosed as having an intracranial syphilitic gumma. | not china |
Although the anti-seizure medications (ASMs), chemotherapy and radiation therapy are also beneficial for seizure treatment, the overall seizure control for GRE continue to be unsatisfactory. | china |
2015. | not china |
In this study acute IR exposure induced cancer cell senescence and apoptosis, but after long-term IR exposure, cancer cells exhibited radioresistance. | china |
At the genus level, 10 bacterial genera (Bacteroides, Pantoea, Methylobacterium-Methylorubrum, Inquilinus, Mycobacterium, Allisonella, Helicobacter, GCA-900066575, IS-44, and Faecalibacterium) were significantly enriched in Group A, whereas five genera (Papillibacter, Scardovia, Turicibacter, Catabacter, and Senegalimassilia) were significantly enriched in Group B. | china |
It was validated as an independent prognostic factor and immunotherapeutic predictor for HCC. | china |
These results indicated that PARP12 is a tumor suppressor that plays an important role in HCC metastasis through the regulation of FHL2 stability and TGF-β1 expression. | china |
In mammary gland cells, GSK3β physically bound and phosphorylated the intracellular domain of two Notch paralogs: N1ICD was positively regulated, but N2ICD was negatively regulated; however, the relationship between Notch3, GSK3β, and EMT in breast cancer is still unclear and crosstalk between Notch3 and GSK3β has not been widely investigated. | china |
In this article, we discuss patient-, clinician-, and systems-level factors that may influence decisions to screen HIV-negative MSM. | not china |
This study examined associations between five single nucleotide polymorphisms (SNPs) of TERT-CLPTM1L (rs402710, rs401681, rs465498, rs4975616, and rs2736100) and lung cancer in a Chinese Han population in the Hubei Province. | china |
The expression levels of PI3-K, PI3-P, AKT, TSC2, mTOR, p70S6K and 4E-BP1 were minimally affected by the wortmannin, perifosine, or rapamycin plus T4 treatments, but their phosphorylated products were greatly affected in A549 lung cancer cells and slightly affected in A549/DDP lung cancer cells. | china |
These tumors carry a very poor prognosis. | not china |
Furthermore, inhibition of FoxM1, combined with oxaliplatin treatment, could significantly promote the senescence of HCC cells. | china |
The selected variables were used to fit a multivariable logistic regression model, which was internally validated by using bootstrap resampling with 20 000 replicates. | not china |
Upregulated differentially expressed genes (DEGs) were identified via the GEO2R and intersected using a Venn diagram. | china |
These genes are closely related to iron death and have great value for the prognosis of renal clear cell carcinoma. | china |
Bile reflux gastritis (BRG), a kind of gastrointestinal disorder in clinical practice, is characterized by regurgitation and inflammation. | china |
Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. | not china |
3.0-T imaging was performed with a 32-channel surface coil and a protocol including diffusion-weighted imaging (DWI), transverse T2-weighted (tT2W) imaging, coronal T2W (cT2W) imaging, sagittal T2W (sT2) imaging, and dynamic contrast-enhanced (DCE) imaging. | not china |
The median survival time for patients with BCLM was 21 months, and 15.5% of the patients were alive more than 3 years. | china |
Atrophic gastritis (AG) is a risk condition for gastric cancer and type I gastric carcinoids. | not china |
Epidemiological studies reported that patients with endometriosis had an increased risk of developing endometriosis-associated ovarian cancer (EAOC). | china |
Two initial studies with drugs in development are promising. | not china |
From March 2014 to December 2015, 85 patients with locally advanced breast cancer were eligible to participate in this study with a schedule of 36.5 Gy in 10 fractions. | china |
Medullary thyroid carcinoma (MTC) may rarely present with paraneoplastic syndromes. | not china |
Stereotactic body radiotherapy (SBRT) and programmed cell death 1 inhibitors have shown potential in treating hepatocellular carcinoma (HCC) in retrospective studies. | china |
5-FU and ovatodiolide were used in drug combination studies. | not china |
We retrospectively collected clinicopathological parameters of breast cancer patients who underwent epirubicin-based NAC and a later surgery from three separate medical centers. | china |
Demographic and migration records were obtained from the US Census Bureau, the Washington State Department of Licensing (DOL), and the US Internal Revenue Service (IRS). | not china |
Although antigen-specific immune responses including cytotoxic T cells (CTLs) against antigen peptide could be enhanced after tumor antigen peptide vaccinations, the immune responses do not necessarily result in a decrease or eradication of tumor cells in the vaccination trials. | not china |
Total soluble solids, pH, and water activity were similar to those reported for other agave sweeteners. | not china |
The same higher levels were found in patients carrying the CCR2 64I/64I genotype. | not china |
Transwell assay and drug sensitivity assay revealed that the malignant cell behaviors in terms of migration, invasion and epirubicin-resistant properties were markedly increased in the MB-231/Epi cells. | china |
Further studies with large sample size for MMP2 should be conducted. | china |
A total of 174 CRC survivors were included in this study. | china |
Recently, comprehensive molecular analyses of large cohorts of primary PBL samples have revealed the mutational landscape as well as the pattern of copy number alterations of this rare lymphoma subtype. | not china |
A total of 70 (22.8%) patients was diagnosed with prostate cancer in Institution 1. | china |
Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). | china |
In this study, we compared natural and deglycosylated PD-L1 expression in lung cancer (LuCa) using a panel of PD-L1 antibodies (28-8, CAL10, 73-10 and SP142). | china |
Modulators involved in m6A RNA methylation were associated with the development of pancreatic cancer. | china |
We analyzed various histopathologic parameters and an immunohistochemical profile consisting of pan-cytokeratin (Pan-CK), epithelial membrane antigen (EMA), CD10, smooth-muscle actin (SMA), S-100 protein, p63, calponin, and carcinoembryonic antigen (CEA). | not china |
Furthermore, we found that CDCP1 can be integrated into larger and denser clusters as functional domains upon activation. | china |
In general, the research on lncRNA represents a new field of cancer research, and the imbalance in lncRNA plays an pivotal role in the occurrence of liver cancer. | china |
We evaluated age-related differences in hepatic natural killer (NK) cell phenotypes in juvenile (2-week-old) and adult (8-week-old) C57BL/6(B6) mice, and determined NK cell cytotoxicity and apoptosis in tumor inoculated mice. | china |
On univariate analysis, a high-degree of tumour budding and the infiltrative type of invasive margin were strong negative prognostic factors. | not china |
The DICE coefficient and mean distance error between dwell positions (MDE) were used to evaluate segmentation and registration performance. | not china |
In vivo, blockade of Wnt/β-catenin signaling by endogenous antagonist Klotho induced WT1 and restored podocyte integrity in adriamycin nephropathy. | china |
We present an enhanced ant colony optimization for continuous domains (EACOR) in the proposed model based on the soft besiege and chase strategies. | china |
Our recent study has revealed that many hospitalized patients with acquired long QT syndrome (ALQTS) are cancer patients. | china |
This resulted in a significant decrease in cell viability, migration and invasion, and an increase in cell apoptosis. | china |
However, during the last years, it has become evident that the role of autophagy is not restricted to degradation alone but also mediates unconventional forms of secretion. | not china |
For PRNCR1 (rs1016343, rs16901946) and POLR2E (rs3787016), we also found the significant association with incresed risk of cancer (all P<0.05). | china |
Peripheral blood-based biomarkers (PBB) predicting response, survival and immune-related adverse events (irAEs) in patients with advanced non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) are still a matter of debate. | china |
Mechanistic investigations suggested that mir-30d regulates a large number of cancer-associated genes, including the apoptotic caspase CASP3. | not china |
However, the associations between DNMTs variations and gastric cancer (GC) risk were still conflicting. | china |
Although the medical science has been developed for decades, the molecular mechanism of endometrial cancer (EC) is not yet completely clear. | china |
Further studies showed that the UTI-mediated inhibition on autophagy was achieved by inhibiting transcriptional factor nuclear factor-κB (NF-κB) signaling pathway. | china |
The median follow-up was 15.2 months. | not china |
Patients were administered 3-day fractionated P 25 mg/m(2) and E 100 mg/m(2) on days 1 to 3, every 3 weeks. | not china |
This study sought to develop a reliable and easy-to-use scoring model to guide the decision to perform postsurgical adjuvant transarterial chemoembolization (PA-TACE) in patients with hepatitis B-related hepatocellular carcinoma (HCC).The study included 235 consecutive patients with hepatitis B-related HCC undergoing PA-TACE at our medical center. | china |
In conclusion, we verified that ZNF334 had a suppressive function of TNBC cell lines by targeting the SFRP1/Wnt/β-catenin signaling axis, which might have the potentials to become a new biomarker for diagnosis and treatment of TNBC patients. | china |
Finally, we verified our results by integrating the patient's gene expression information and radiomics information. | china |
Five metabolites, i.e. | china |
A retrospective gastric adenocarcinoma cohort (n = 154) was collected from our hospital to test their tissue expression of SLC39A1 through immunohistochemical staining method. | china |
The impact of additional PET/CT scanning on therapeutic decisions were presented. | china |
But the act of UPP1 in thyroid cancer is not explicit. | china |
Sarcopenia is reported to be associated with complications after surgery. | not china |
Here, we used serial dilution and single-cell transplantation assays to identify MMTV-Her2/Neu mouse mammary TICs as CD24(+):JAG1(-) at a frequency of 2-4.5%. | not china |
Also, intrathecal RvD5 reduced mechanical allodynia in male mice lacking Trpv1 or Trpa1, whereas female mice with Trpv1 or Trpa1 deficiency had no response to RvD5. | not china |
Stoma creation through the extraperitoneal route reportedly reduces the risk of parastomal hernia and stomal prolapse after abdominoperineal resection (APR) for rectal cancer. | not china |