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1
00:00:00,000 --> 00:00:05,440
ุงู„ู€ slide ุจุงู„ุถุจุท ู‡ูˆ ุงู„ู„ูŠ ู‚ุตุฏู‡ุŒ ุจุฏูŠ ูŠุนู†ูŠ ุฃุชูƒู„ู… ุนู†ู‡

2
00:00:05,440 --> 00:00:14,660
ุงู„ููƒุฑุฉ ุฃู†ู‡ ู‡ู†ุงูƒ ุฏุฑุฌุฉ ุนุงู„ูŠุฉ ู…ู† ุงู„ุงุฎุชู„ุงูุงุช ุจูŠู† ุงู„ู€

3
00:00:14,660 --> 00:00:22,460
DNA ู„ู„ุจุดุฑุŒ ุจุญูŠุซ ุฃู†ู‡ ุจุฃูŠ ุฃุณู„ูˆุจ ุฃูˆ ุจุฃูŠ ูŠุนู†ูŠ ุนุฏุณุฉ

4
00:00:22,460 --> 00:00:27,980
ู…ูƒุจุฑุฉ ู…ุณุชุฎุฏู…ุฉุŒ ู…ู…ูƒู† ู†ู„ุงู‚ูŠ ุฏุฑุฌุงุช ู…ู† ุงู„ุงุฎุชู„ุงูุงุช ููŠ

5
00:00:27,980 --> 00:00:33,870
ุงู„ู€ SNPsุŒ ุงู„ู„ูŠ ู‡ูŠ Single Nucleotide PolymorphismsุŒ ูู‡ูŠ

6
00:00:33,870 --> 00:00:40,610
ุจุชูƒูˆู† ุนู„ู‰ ู…ุณุชูˆู‰ ุญุฑู ูˆุงุญุฏุŒ ูŠุนู†ูŠ ุนู„ู‰ ู…ุณุชูˆู‰ ุฅุฐุง

7
00:00:40,610 --> 00:00:50,090
ุจุชุฎูŠู„ู†ุง ุงู„ู€โ€ฆ ุงู„ู€GenomeุŒ ูƒู„ ุงู„ู€โ€ฆ ูƒู„ ุงู„ู‚ุตุงุฆุฏ ุจุงู„ู„ุบุฉ

8
00:00:50,090 --> 00:00:56,450
ุงู„ุนุฑุจูŠุฉ ู…ุซู„ุงู‹ุŒ ุงู„ู€โ€ฆ ุงู„ุจุฑูˆุชูŠู† ู‡ูˆ ู‚ุตูŠุฏุฉ ู…ุญุฏุฏุฉุŒ ุงู„ุจุฑูˆุชูŠู†

9
00:00:56,450 --> 00:01:01,750
ูŠุชูƒูˆู† ู…ู† ุฃุญุฑูุŒ ู…ุงุดูŠุŸ ู„ุฃู† ุงู„ู‚ุตูŠุฏุฉ ุชุชูƒูˆู† ู…ู† ุฃุจูŠุงุช

10
00:01:01,750 --> 00:01:09,050
ูˆุงู„ุฃุจูŠุงุช ุชุชูƒูˆู† ู…ู† ุฃุญุฑูุŒ ูุงู„ู€โ€ฆ ุงู„ู€ SNP ู‡ูˆ ุงุฎุชู„ุงู

11
00:01:09,050 --> 00:01:14,910
ููŠ ุญุฑู ูˆุงุญุฏุŒ ูˆุงุชูู‚ู†ุง ุนู„ู‰ ุฃู†ู‡ ุชู‚ุฑูŠุจุงู‹ ู†ุชูƒู„ู… ุนู„ู‰ ุฃู†ู‡

12
00:01:14,910 --> 00:01:19,570
ููŠ ุญูˆุงู„ูŠ ู…ู† ุฎู…ุณุฉ ุฅู„ู‰ ุนุดุฑุฉ ู…ู„ุงูŠูŠู† SNPs ุนุงุฏุฉู‹ ููŠ ุฃูŠ

13
00:01:19,570 --> 00:01:22,330
ุฌูŠู†ูˆู… ุจุดุฑูŠุŒ ูŠุนู†ูŠ

14
00:01:25,820 --> 00:01:34,280
ู‡ูŠ ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ุญุฑู ุงู„ุฏู‚ูŠู‚ ุงู„ู„ูŠ ู‡ูˆ ุงู„ู…ุญุฏุฏุŒ ูŠุนู†ูŠ ุฃู…ุง

15
00:01:34,280 --> 00:01:41,980
ู„ู…ุง ู†ูŠุฌูŠ ู†ุชูƒู„ู… ุนู†ุŒ ุจุงู„ู†ุณุจุฉ ู„ู€โ€ฆ ู†ูŠุฌูŠ ู†ุชูƒู„ู… ุนู„ู‰

16
00:01:41,980 --> 00:01:49,360
ู…ุณุชูˆูŠุงุช ุฃูˆุณุน ู…ู† ุงู„ู€โ€ฆ ู…ู† ุงู„ู€Variations ุฃูˆ ุงู„ุงุฎุชู„ุงูุงุช

17
00:01:49,360 --> 00:01:55,370
ูˆู†ุดูˆู ุนู„ู‰ ู…ุณุชูˆู‰ ุฃูƒุจุฑุŒ ุฃู†ุง ุจุฃุนุชุจุฑ ู‡ุฐุง ุงู„ู€ "ุณู„ุงูŠุฏ" ู…ู†

18
00:01:55,370 --> 00:02:01,550
ุฃู‡ู… ุงู„ู€ "ุณู„ุงูŠุฏุงุช"ุŒ ุฅุฐุง ุจุฏูŠ ุฃุญุฏ ูŠู‚ูˆู„ ูุงู‡ู… ุดูŠุกุŒ ูŠูƒูˆู†

19
00:02:01,550 --> 00:02:08,910
ู…ู†ุชุจู‡ ู„ู‡ุŒ ู„ู…ุง ู†ูŠุฌูŠ ู†ุฏุฑุณ ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ู€ "ูƒุฑูˆู…ูˆุฒูˆู…"

20
00:02:08,910 --> 00:02:15,210
ูƒู„ู‡ุŒ ูˆุงู„ู€DNA ูƒู„ู‡ุŒ ูˆุงู„ุฌูŠู†ูˆู… ูƒู„ู‡ุŒ ู‡ูŠูƒ ุจุดูƒู„ ุนุงู…ุŒ ูŠุนู†ูŠ

21
00:02:15,210 --> 00:02:21,650
ู†ุนุชุจุฑู‡ ุจุดูƒู„ ู…ุด ุฏู‚ูŠู‚ ูƒุซูŠุฑุŒ ู…ุด ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ุฃุญุฑู

22
00:02:22,150 --> 00:02:25,590
ุจุณู…ูŠู‡ู… ุงู„ู€ Standard KaryotypingุŒ ูˆุญูƒูŠุช ู„ูƒู… ูƒูŠู

23
00:02:25,590 --> 00:02:29,750
ุจูŠูƒูˆู†ุŒ ูˆุจูŠูƒูˆู† ุนู„ู‰ ู…ุณุชูˆู‰ ุนุดุฑุฉ ุฃูˆ ุชุณุนุฉ ุงู„ู€

24
00:02:29,750 --> 00:02:33,890
Nucleotide Base Pairs ูƒู„ู‡ู…ุŒ ูŠุนู†ูŠ ุงู„ู…ู„ูŠุงุฑุงุชุŒ ู…ุฑุฉ

25
00:02:33,890 --> 00:02:39,710
ูˆุงุญุฏุฉุŒ ู‡ุฐุง ุงู„ู€ KaryotypingุŒ ุฅุฐุง ุจุชุทู„ุน ุนู„ู‰ ุงู„ู€ Bands

26
00:02:39,710 --> 00:02:44,250
ุงู„ู„ูŠ ุจุดูˆูู‡ ุจุงุณุชุฎุฏุงู… ุตุจุบุงุชุŒ ูŠุง ุฃู…ุง Routine Binding

27
00:02:44,250 --> 00:02:48,530
ุฃูˆ High Resolution BindingุŒ ูŠุนู†ูŠ ุจุดูˆู ุงู„ูุฑู‚ูŠุงุช

28
00:02:48,530 --> 00:02:53,330
ุงู„ู…ูˆุฌูˆุฏุฉ ุนู„ู‰ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุชุŒ ูˆุจุญุงูˆู„ ุฃุฏุฑุณู‡ุง ููŠ ู…ุณุชูˆู‰

29
00:02:53,330 --> 00:02:57,770
ุฃุฏู‚ ุดูˆูŠุฉุŒ ุจุนุฏูŠู† ููŠ ุนู†ุฏูŠ techniques ู‡ู†ุงุŒ ู…ุฌู…ูˆุนุฉ

30
00:02:57,770 --> 00:03:05,530
ู…ู† ุฃุตุนุจ ุงู„ุฃุดูŠุงุกุŒ ูˆูŠู…ูƒู† ู„ูƒู„ ุชุดุฎูŠุต ููŠู‡ ุฃู„ูŠุฉ

31
00:03:05,530 --> 00:03:10,130
ู…ุนูŠู†ุฉ ู†ุณุชุฎุฏู…ู‡ุงุŒ ุงู„ู„ูŠ ู‡ูŠ ุงู„ู€FISH

32
00:03:10,130 --> 00:03:15,000
ูˆุงู„ู€MicroarrayุŒ ูˆุงู„ู€MicrochromosomeุŒ ูŠุนู†ูŠ ู‡ู†ุง ูƒุฃู†ู‡ ุฃู†ุง

33
00:03:15,000 --> 00:03:22,440
ุจุตูŠุฑ ุฃุจุญุซ ููŠ ุงู„ู‚ุตุงุฆุฏุŒ ุจุดูƒู„ุŒ ู†ุณู…ูŠู‡ู… ุฃุจูŠุงุช ุดุนุฑ ู…ุนูŠู†ุฉ

34
00:03:22,440 --> 00:03:27,820
ู…ุซู„ุงู‹ุŒ ูŠู…ูƒู† ุฃุตูŠุฑ ุฃุฏูˆุฑ ููŠู‡ู… ู†ูุณ ุงู„ุจูŠุช ุฃูˆ ุดูŠุก ุฒูŠ ู‡ูŠูƒ

35
00:03:27,820 --> 00:03:32,220
ูŠุนู†ูŠุŒ ู…ุฌู…ูˆุนุฉ ุฃูƒุจุฑ ุดูˆูŠุฉ ู…ู† ู‡ู†ุงุŒ ู†ุจุญุซ ุนู† ู„ุญุธุฉ ู…ุญุฏุฏุฉ

36
00:03:32,670 --> 00:03:36,310
ูˆููŠ ู„ู…ุง ุฃู†ุง ู‚ุงุนุฏ ุฃูุญุต ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ู€โ€ฆ

37
00:03:36,310 --> 00:03:40,990
ุงู„ู€ Nucleotide ูˆุงู„ู€ Base Pair ูƒู„ ูˆุงุญุฏ ู„ูˆุญุฏู‡ุŒ ุจุณูˆูŠ

38
00:03:40,990 --> 00:03:44,790
Whole Genome SequencingุŒ ู‡ุฐู‡ ุจูŠูƒูˆู† ุงู„ู€Resolution

39
00:03:44,790 --> 00:03:50,550
ู„ุญุฏ ูˆุงุญุฏ ุงู„ู€ NucleotideุŒ ุชุตูŠุฑ ุฏู‚ุฉ ุนุงู„ูŠุฉ ุฌุฏุงู‹ุŒ ูู‡ุฐู‡

40
00:03:50,550 --> 00:03:56,910
ูŠุนู†ูŠ ูƒู„ ูˆุงุญุฏุฉ ู…ู†ู‡ู… ู…ููŠุฏุฉ ููŠ ุญุงู„ุฉ ู…ุนูŠู†ุฉุŒ ููŠ ุชุดุฎูŠุต

41
00:03:56,910 --> 00:04:03,130
ู…ุนูŠู†ุŒ ููŠ ู…ุฑุถ ู…ุนูŠู†ุŒ ู„ู…ุง ูŠูƒูˆู† ุนู†ุฏูŠ ู…ุดุงูƒู„ ุนู„ู‰ ุดูƒู„

42
00:04:03,130 --> 00:04:08,110
ู…ุซู„ุงู‹ ุฒูŠ Down SyndromeุŒ ู„ุงุŒ ุงู„ู…ุดูƒู„ุฉ ุนุงุฏุฉู‹ ุฅู†ู‡

43
00:04:08,110 --> 00:04:14,750
ูƒุฑูˆู…ูˆุฒูˆู… ูƒุงู…ู„ ููŠู‡ ุฒูŠุงุฏุฉุŒ Trisomy 21 ู…ุซู„ุงู‹ุŒ ุจูŠู†ู…ุง

44
00:04:14,750 --> 00:04:19,530
ู…ุซู„ุงู‹ ุฅุฐุง ุจุฏูˆุฑ ุนู„ู‰ ู…ุฑุถ ุขุฎุฑุŒ ูŠู…ูƒู† ุฃุนู…ู„ Whole Genome

45
00:04:19,530 --> 00:04:25,490
SequencingุŒ ูู‡ุฐู‡ ุจุฃุนุชุจุฑู‡ุง ู…ู† ุฃู‡ู… ุงู„ู€Slides ุงู„ู„ูŠ ู„ุงุฒู…

46
00:04:25,490 --> 00:04:30,810
ูˆุงุญุฏ ูŠุชุฎูŠู„ู‡ ูˆูŠุนุฑูู‡ุŒ ูˆูŠุนุฑู ุฃู…ุซู„ุฉ ุนู„ูŠู‡ุŒ ูˆุดูˆ ูˆู„ูŠู‡

47
00:04:30,810 --> 00:04:37,150
ุจู†ุญุชุงุฌ ููŠ ู‡ุฐู‡ ุงู„ุทุฑูŠู‚ุฉุŒ ูุงู„ุขู†ุŒ ู‡ุงูŠ ุงู„ู„ูŠ ุณู…ูˆู‡ุง ุงู„ู€

48
00:04:37,150 --> 00:04:44,270
IdeogramุŒ ุงู„ู€ G-bandingุŒ ุงู„ู†ุทุงู‚ุงุช ุงู„ู„ูŠ ู‡ูŠ ุงู„ู…ูˆุฌูˆุฏุฉ

49
00:04:44,270 --> 00:04:51,850
ุนู„ู‰ ุงู„ู€ ูƒุฑูˆู…ูˆุฒูˆู…ุงุชุŒ ู„ู…ุง ู†ูƒูˆู† ููŠ ู…ุฑุญู„ุฉ ุงู„ู€ Metaphase

50
00:04:51,850 --> 00:04:58,490
ู…ู† ุงู„ู€โ€ฆ ู…ู† ุงู„ู€ Cell DivisionุŒ ูˆุจูŠูƒูˆู† ุงู„ู€ DNA ุนู„ู‰ ุดูƒู„

51
00:04:58,490 --> 00:05:07,850
DNA compressedุŒ ูŠุนู†ูŠ ู…ุถุบูˆุทุŒ ูˆุจูŠูƒูˆู† ุนู„ู‰ ุดูƒู„ ุฃุตุบุฑ ุดูŠุก

52
00:05:07,850 --> 00:05:16,430
ุญุชู‰ ู†ู‚ุฏุฑ ู†ู‚ุณู… ุงู„ู€โ€ฆ ุงู„ู€โ€ฆ ุงู„ู€ two sets of chromosomes

53
00:05:16,430 --> 00:05:25,360
to each cellุŒ ูู‡ุฐู‡ ุจุชูƒูˆู† ูƒูŠู ุจุชูƒูˆู†ุŸ ู‡ู†ุง ุฑุคูŠุฉ ุฃุฏู‚

54
00:05:25,360 --> 00:05:30,860
ูˆู…ู‚ุฑุจุฉ ุฃูƒุซุฑ ู„ู„ู€ Chromosome ูˆุงู„ู€ Bands ุงู„ู„ูŠ ู…ูˆุฌูˆุฏุฉ

55
00:05:30,860 --> 00:05:36,020
ุนู„ูŠู‡ุง ูˆุชู‚ุณูŠู…ุงุชู‡ุงุŒ ูˆููŠ High Resolution BandingุŒ ูŠุนู†ูŠ

56
00:05:36,020 --> 00:05:42,520
ุญุชู‰ ุจูŠุนุทูŠู†ุง ุนุฏุฏ ุฃูƒุจุฑ ู…ู† ุงู„ุฏู‚ุฉุŒ ู†ุดูˆูู‡ ู‡ูˆู†ุŒ ุงุญู†ุง

57
00:05:42,520 --> 00:05:48,020
ุจู†ุณุชุฎุฏู… ุชู‚ู†ูŠุฉ ุงู„ู€ FISHุŒ ุงู„ู€ Fluorescence ุงู„ู„ูŠ ู‡ูŠ ุฅู†ู‡

58
00:05:48,020 --> 00:05:54,880
ููŠู‡ ุตุจุบุฉ ุจุชุดุน ุนู„ูŠู‡ุง ุถูˆุก ู…ุนูŠู†ุŒ ุจุชุนุทูŠู†ูŠ ุถูˆุก ุซุงู†ูŠุŒ ูุนุงุฏุฉู‹

59
00:05:54,880 --> 00:06:00,000
ู†ุฎุชุงุฑ ุฃู†ูˆุงุน ุงู„ุตุจุบุงุช ุงู„ู„ูŠ ุจุชุนุทูŠู†ุง ููŠู‡ุง ุงู„ู€ Same

60
00:06:00,000 --> 00:06:04,240
Excitation Wavelength ู„ู„ู€ Laser ุฃูˆ ู„ู„ู€ Light

61
00:06:04,240 --> 00:06:08,420
ูˆุจุชุนุทูŠู†ุง Different Emission WavelengthุŒ ุญุชู‰ ุฃู‚ุฏุฑ

62
00:06:08,420 --> 00:06:16,500
ุฃู…ูŠุฒ ุฅูŠุด ุงู„ู„ูŠ ุจุดูˆูู‡ุŒ ุงู„ู€ Dye ู‡ู†ุง ุฃู†ุง ุญุงุทุทู‡ุง ุนู„ู‰

63
00:06:16,500 --> 00:06:24,410
Probe ุจุชุฑูˆุญุŒ ุจุชุฏูˆุฑ ุนู„ู‰ certain DNA sequence ุฃู†ุง ู…ู‡ุชู…

64
00:06:24,410 --> 00:06:32,510
ููŠู‡ุŒ ูู‡ู†ุง ูŠุนู†ูŠ ุฃู†ุง ุจุฏูˆุฑ ุงู„ู€ "ูƒู„ู…ุฉ" ู†ุฑุฌุนู‡ุง ู„ุจูŠุช

65
00:06:32,510 --> 00:06:40,370
ุดุนุฑ ู…ุนูŠู† ููŠ ุงู„ู‚ุตุงุฆุฏุŒ ูุจุฑุจุท ุนู„ูŠู‡ ู…ุงุฏุฉ ู…ู„ูˆู†ุฉุŒ ูˆุจุญุทู‡ุง

66
00:06:40,370 --> 00:06:44,550
ุนู„ู‰ ุงู„ุฎู„ุงูŠุง

67
00:06:44,550 --> 00:06:49,120
ุงู„ู„ูŠ ู‡ูŠ ููŠ ุญุงู„ุฉ ุงู„ู€ MetaphaseุŒ ูˆูŠูƒูˆู† ุนู†ุฏูƒ ูƒุฑูˆู…ูˆุฒูˆู…ุงุช

68
00:06:49,120 --> 00:06:55,200
ูˆุจุญุงูˆู„ ุฃุดูˆู ูˆูŠู† ููŠ ุงุชู‘ุตุงู„ ู„ู‡ุฐู‡ ุงู„ู€ Probe ุจุงู„ุฅูŠุด

69
00:06:55,200 --> 00:06:59,640
ุงู„ู…ูุฑูƒู‘ุจ ู„ู‡ุงุŒ ูŠุนู†ูŠ ุฃู„ุงู‚ูŠ ุงู„ุจูŠุช ุงู„ู„ูŠ ุฃู†ุง ุฏูˆุฑู‘ุช ุนู„ูŠู‡

70
00:06:59,640 --> 00:07:04,860
ู…ู† ุงู„ู‚ุตูŠุฏุฉุŒ ุนุดุงู† ุชู„ุฒู‚ ุนู„ูŠู‡ุŒ ูƒู…ุฌู…ูˆุนุฉ ุทูˆูŠู„ุฉ ุดูˆูŠุฉ ู…ุด

71
00:07:04,860 --> 00:07:11,000
Single NucleotideุŒ ูˆู‡ู†ุง ู…ุฑุฉ ุจู†ุนุชุจุฑู‡ุง ุฅูŠุฌุงุจูŠุฉ

72
00:07:11,000 --> 00:07:16,530
ูˆู…ุฑุฉ ุจู†ุนุชุจุฑู‡ุง ุณู„ุจูŠุฉุŒ ู‡ู†ุง ู…ุซู„ุงู‹ ุงู„ู€ Binding ุชุจุน ุงู„ู€

73
00:07:16,530 --> 00:07:23,810
X-ChromosomeุŒ ู…ุงุดูŠุŸ ูˆู‡ูƒุฐุง ูŠูƒูˆู† ุดูƒู„ู‡ุŒ ูˆูŠูƒูˆู† ููŠู‡ ุญุงู„ุงุช

74
00:07:23,810 --> 00:07:29,270
ู…ุฎุชู„ูุฉุŒ ูˆุฃุดูŠุงุก ู…ุฎุชู„ูุฉุŒ ุงู„ู€ Microarray ุจุฑุถู‡ ูŠุนู†ูŠ

75
00:07:29,270 --> 00:07:34,410
ููƒุฑุชู‡ุงุŒ ุฃู‡ู… ุดูŠุก ุงู„ูˆุงุญุฏ ูŠุงุฎุฐู‡ุงุŒ ุฃู†ู‡ ู‡ู†ุง ุฃู†ุง ุจุฏูˆุฑ ุนู„ู‰

76
00:07:34,410 --> 00:07:44,030
ุจุดูƒู„ ุนุงู…ุŒ ุนู„ู‰ ู‚ุทุน DNAุŒ ูŠุนู†ูŠ Sequence ู…ุนูŠู†ุฉุŒ ุจูŠู…ูƒู†

77
00:07:44,030 --> 00:07:51,410
ู…ุซู„ุงู‹ ุฎู…ุณูŠู†ุŒ ู…ุฆุฉ Base ู…ุญุฏุฏุฉุŒ ุจุชุฑุชูŠุจ ู…ุนูŠู†ุŒ ูŠุนู†ูŠ ุฃุญุฑู

78
00:07:51,410 --> 00:07:58,490
ู…ุนูŠู†ุฉ ุจุชูƒูˆู† ุจุดูƒู„ ู…ุนูŠู†ุŒ ูู‡ุฐู‡ ุจุฏู†ุง ูŠุนู†ูŠ ูŠุณุชุทูŠุน ุงู„ูˆุงุญุฏ

79
00:07:58,490 --> 00:08:05,090
ูŠุณุชุฎุฏู…ู‡ุงุŒ ูˆูŠุฏุฑุณ ุงู„ู…ูˆุถูˆุนุŒ ูˆู‡ูŠ ู…ููŠุฏุฉ ุฅู†ู‡ ูŠุชุฎูŠู„ู‡ุง

80
00:08:05,090 --> 00:08:09,960
ุงู„ูˆุงุญุฏ ููŠ ุชุดุฎูŠุต ุญุงู„ุฉ ู…ุญุฏุฏุฉุŒ ุฑุงุญ ู†ุญูƒูŠ ุนู† ุงุณุชุฎุฏุงู…ุงุชู‡ุง

81
00:08:09,960 --> 00:08:17,000
ูˆูƒูŠู ุชูƒูˆู†ุŒ ููŠ ุณุคุงู„ ู…ู† ุงู„ุฏูƒุชูˆุฑุฉ ู‡ุฏูŠู„ุŒ ุจุชุชูƒู„ู…ุŒ ุจุชุณุฃู„

82
00:08:17,000 --> 00:08:20,620
ูŠุนู†ูŠ ู‡ู„ ู†ุนุชุจุฑ ุงู„ู€ SNPs ู…ู† ุถู…ู† ุงู„ู€ Polymorphisms

83
00:08:20,620 --> 00:08:24,540
ูˆุงู„ู€ Substitutions ุถู…ู† ุงู„ู€ MutationsุŒ ุนู„ู…ุงู‹ ุฃู† ุงู„ุงุซู†ูŠู†

84
00:08:24,540 --> 00:08:29,260
ุจูŠุตูŠุฑ ููŠู‡ู… Single BaseุŒ ูŠุนู†ูŠุŸ ู„ุงุŒ ู„ุงุŒ ุงุณู…ุนูŠุŒ ูƒู„ู…ุฉ

85
00:08:29,260 --> 00:08:38,990
PolymorphismุŒ ุชุนุฏุฏ ุงู„ุตูˆุฑุŒ ู…ุงุดูŠุŸ ู‡ูŠ ุงู„ุญุงู„ุฉ ุนู†ุฏู…ุง ูŠูƒูˆู†

86
00:08:38,990 --> 00:08:47,790
ู†ุณุจุฉ ุญุฏูˆุซ ู‡ุฐู‡ ุงู„ุทูุฑุฉ ุฃูƒุซุฑ ู…ู† 1% ู…ู† ุงู„ู€ Human

87
00:08:47,790 --> 00:08:54,510
populationุŒ ูŠุนู†ูŠ ูƒู„ู…ุฉ ุงู„ู€ MutationุŒ okayุŒ ูŠุนู†ูŠ ุงู„ู„ูŠ ู‡ูŠ

88
00:08:54,510 --> 00:08:59,890
ู‚ุถูŠุฉ ูƒู„ู…ุฉ ุฅู†ู‡ ูŠู‚ูˆู„ ุทูุฑุฉุŒ ุงู„ุทูุฑุฉ ุจุฏู„ ูˆุงุญุฏุŒ ูŠุนู†ูŠ ูŠูƒูˆู†

89
00:08:59,890 --> 00:09:06,860
ู…ุชุฃูƒุฏ ุฃูˆู„ ุดูŠุก ุฃู†ู‡ ู‡ูˆ ุชุบูŠุฑ ุนู† ุงู„ุทุจูŠุนูŠุŒ ูู…ู…ูƒู† ุฃู†ุง ุฅุฐุง

90
00:09:06,860 --> 00:09:11,260
ู…ุง ุนู†ุฏูŠ ุฏุฑุงุณุฉ ูƒุงู…ู„ุฉ ู„ูƒู„ ุงู„ุจุดุฑุŒ ุจุญูŠุซ ุฃู†ุง ุฃุนุฑู ุดูˆ ู‡ูˆ

91
00:09:11,260 --> 00:09:18,400
ุทุจูŠุนูŠุŒ ุญุชู‰ ุฃู‚ุฑุฑ ุดูˆ ู‡ูˆ ู…ุด ุทุจูŠุนูŠุŒ ู‡ู†ุง ุจุชุตูŠุฑ ุงู„ุฃู…ูˆุฑ ูŠุนู†ูŠ

92
00:09:18,400 --> 00:09:27,420
ุตุนุจุฉ ุดูˆูŠุฉ ู„ุชู‚ูŠูŠู…ู‡ุงุŒ ุจูŠู†ู…ุง ุนู†ุฏู…ุง ู†ุชูƒู„ู… ุนู† ูƒู„ู…ุฉ ูƒุงู†ุช

93
00:09:27,420 --> 00:09:33,800
ุถู…ู† ุชุนุฑูŠู ุงู„ู€ PolymorphismุŒ ุฃู† ู†ุณุจุฉ ุญุฏูˆุซ ู‡ุฐู‡ ุงู„ุธุงู‡ุฑุฉ

94
00:09:34,510 --> 00:09:42,850
ุจุชูƒูˆู† ุจู†ุณุจุฉ ุฃูƒุซุฑ ู…ู† 1% ู…ู† ุงู„ู€ PopulationุŒ ู„ู…ุง ู†ุชูƒู„ู…

95
00:09:42,850 --> 00:09:50,430
ุนู† SNPุŒ ุจุงู„ุฐุงุช ุนู„ู‰ ู…ูƒุงู† ู…ุญุฏุฏุŒ ููŠ ู…ุญู„ ู…ุญุฏุฏุŒ ููŠ

96
00:09:50,430 --> 00:09:56,150
ุฏุฑุงุณุฉ ู…ุนูŠู†ุฉุŒ ู…ุงุดูŠุŸ ุนู†ุฏ ู…ุดุงู‡ุฏุชู‡ุงุŒ ุจุฏู†ุง ู†ุณู…ูŠู‡ุง SNP

97
00:09:56,150 --> 00:10:02,090
ู‡ูŠ ูƒู„ู‡ุง ุฃู†ูˆุงุน ุชูุฑุนุงุช ุงู„ุงุฎุชู„ุงู

98
00:10:02,090 --> 00:10:08,390
ุฃู†ู‡ ุญูƒูŠู†ุง ุงู„ุฃู†ูˆุงุน ุงู„ุซุงู†ูŠุฉ ู…ู† ุงู„ู€ Mutations ุงู„ู„ูŠ ู‡ูŠ

99
00:10:08,390 --> 00:10:15,730
ุฅู†ู‡ุง ู‚ุทุนุฉ ูƒุจูŠุฑุฉ ุชุชูƒุฑุฑุŒ ู‚ุทุนุฉ ูƒุจูŠุฑุฉ ุชู†ู‚ู„ุจุŒ ุชุณู…ู‰ inversionุŒ ู‚ุทุนุฉ ูƒุจูŠุฑุฉ ุชู†ุญุฐูุŒ ู‡ุงูŠ ููŠ ุงู„ุบุงู„ุจ ูŠุนู†ูŠ

100
00:10:15,730 --> 00:10:22,950
ุชุฃุซูŠุฑู‡ุง ุดุฏูŠุฏ ุนู„ู‰ ูˆุธูŠูุฉ ุงู„ู€ Protein ูˆุงู„ุฌูŠู† ุงู„ู…ุนู†ูŠ

101
00:10:22,950 --> 00:10:27,890
ููŠ ู‡ุฐู‡ ุงู„ุธุงู‡ุฑุฉ ุฃูˆ ููŠ ู‡ุฐู‡ ุงู„ู‚ุทุนุฉุŒ ุจูŠู†ู…ุง ู„ู…ุง ู†ุชูƒู„ู… ุนู„ู‰

102
00:10:27,890 --> 00:10:35,680
ุงู„ู€ SNP ุจุงู„ุฐุงุชุŒ ู„ุฏู‰ ุงู„ูˆุงุญุฏ ูŠุชุฐูƒุฑ ุฃู†ู‡ู… ุฃู†ูˆุงุน

103
00:10:35,680 --> 00:10:41,940
ุงู„ุชูุฑุงุช ุฃูˆ ุฃู†ูˆุงุน ุงู„ู€ Mutations ุงู„ู„ูŠ ุจุชุญุฏุซ

104
00:10:41,940 --> 00:10:46,600
ูˆู„ูƒู† ู‚ุฏ ูŠูƒูˆู† ููŠ ุฃุญูŠุงู† ูƒุซูŠุฑุฉ ู…ุงู„ู‡ุงุด ู‚ูŠู…ุฉ ูŠุนู†ูŠ

105
00:10:46,600 --> 00:10:50,900
ูˆุธูŠููŠุงู‹ุŒ ู‡ูŠ ุบูŠุฑ ูุงุนู„ุฉ ูˆุบูŠุฑ ู…ุณุจุจุฉ ู„ู…ุฑุถุŒ ูŠุนู†ูŠ ุดุบู„

106
00:10:50,900 --> 00:10:58,180
ู…ูˆุฌูˆุฏุฉ ููŠ ุงู„ู€ "DNA"ุŒ ุนุดุงู† ู†ุจูŠู† ุงู„ุงุฎุชู„ุงู ุจูŠู† ุงู„ู€

107
00:10:58,180 --> 00:11:02,720
"DNA" ุชุจุน ุงู„ุฃุจ ู…ู† ุงู„ุฃู…ุŒ ููŠ ุฌูŠู† ู…ุนูŠู†ุŒ ููŠ ู…ูƒุงู† ู…ุนูŠู†ุŒ ูˆู„ูŠุณ

108
00:11:02,720 --> 00:11:07,480
ุจุงู„ุถุฑูˆุฑุฉ ุฃู† ูŠู†ุชุฌ ุนู†ู‡ุง ุงุฎุชู„ุงู„ ููŠ ูˆุธูŠูุฉ ุฃูˆ ุดูƒู„ ุฃูˆ

109
00:11:07,480 --> 00:11:12,780
ุชุฑูƒูŠุจ ุงู„ุจุฑูˆุชูŠู† ุงู„ู†ุงุชุฌุŒ ุฅู† ุดุงุก ุงู„ู„ู‡ ุฃู† ุงู„ุฃู…ุฑ ูˆุงุถุญ

110
00:11:16,540 --> 00:11:22,080
ุฏูƒุชูˆุฑุŒ ู‡ูŠ ุจุชุณุฃู„ ุจุฑุถู‡ ุฅู†ู‡ ูŠุนู†ูŠ ุงู„ูุฑู‚ ุจูŠู†

111
00:11:22,080 --> 00:11:25,380
ุงู„ู€ Mutation ูˆุงู„ู€ Polymorphism ู‡ูˆ ุงู„ู†ุณุจุฉุŸ

112
00:11:28,000 --> 00:11:36,580
ุงู„ุงุซู†ูŠู† ุชู‚ุฑูŠุจุงู‹ ู…ุชุฑุงุฏูุงู†ุŒ ูŠุนู†ูŠ ู†ุณุจุŒ ุชุนุชุจุฑ ูŠุนู†ูŠ

113
00:11:36,580 --> 00:11:42,280
ุชุนุฏุฏ ุงู„ุตูˆุฑุŒ ุจุงูุชุฑุงุถ ุฅู†ู‡ ูŠุนู†ูŠ ู…ุซู„ุงู‹ ุฃู†ุง ููŠ ู…ูƒุงู†

114
00:11:42,280 --> 00:11:46,720
ู…ุนูŠู†ุŒ ุนู†ุฏูŠ ุตูˆุฑุชูŠู†ุŒ ุซู„ุงุซุฉ ุจูŠู† ุงู„ุจุดุฑุŒ ู…ุงุดูŠุŸ ุงู„ุทูุฑุฉ

115
00:11:46,720 --> 00:11:51,400
ุฅุฐุง ููŠ ุดูŠุก ูƒุงู† ุงู„ุฃุตู„ ูŠูƒูˆู† ู…ูˆุฌูˆุฏุŒ ูˆุจุนุฏูŠู† ุตุงุฑุช

116
00:11:51,400 --> 00:11:54,720
ุชุบูŠู‘ุฑุŒ ุงุฎุชู„ุงู

117
00:11:55,130 --> 00:12:01,570
ุจูŠู† ุงู„ูˆุงู„ุฏูŠู† ูˆุงู„ุงุจู† ุฃูˆ ุงู„ุจู†ุชุŒ ูŠุนู†ูŠ ุฅู†ู‡ ุชุบูŠู‘ุฑ ุดูŠุก ุตุงุฑ

118
00:12:01,570 --> 00:12:08,470
ูŠุชุทูˆุฑุŒ ู„ู…ุง ู†ุณุชุฎุฏู… PolymorphismุŒ ูŠุนู†ูŠ ุญุชู‰ ูŠุนุฑููˆู‡

119
00:12:08,470 --> 00:12:15,790
ุจุดูƒู„ ุฃูƒุซุฑุŒ ุจูŠู‚ูˆู„ ุฅู† ู†ุณุจุชู‡ ูƒุทูุฑุฉ ููŠ ุงู„ู…ุฌุชู…ุน ุฃูˆ ููŠ

120
00:12:15,790 --> 00:12:20,890
ุงู„ู„ูŠ ุนู†ุฏู‡ู… ุงู„ู‚ูŠุงู… ุจุงู„ุฏุฑุงุณุฉ ุฃูƒุซุฑ ู…ู† 1%ุŒ ูŠุนู†ูŠ ุงู„ุฃู‚ู„ ู…ู†

121
00:12:20,890 --> 00:12:25,190
1% ู„ุง ุชูุนุชุจุฑ PolymorphismุŒ ูŠุนู†ูŠ ู‡ูŠูƒ ู…ุฑุงุช ู†ุนุชุจุฑู‡ุง

122
00:12:25,190 --> 00:12:33,030
ุจุณ ุงู„ู€ SNP ูŠุนู†ูŠ ู‡ูˆ ู‡ู†ุง ู…ุง ู…ู…ูƒู†ุด ู†ุนุชุจุฑู‡ Polymorphism

123
00:12:33,030 --> 00:12:38,150
ู„ุฌูŠู† ู…ุนูŠู†ุŒ ูŠุนู†ูŠุŒ ู…ุน ุฃู†ู‡ ูƒู„ู…ุฉ Polymorphism ุฏุงุฎู„ ููŠู‡

124
00:12:38,150 --> 00:12:47,110
ูŠุนู†ูŠุŒ ู„ุฃู†ู‡ ู‚ุฏ ู„ุง ูŠูƒูˆู† ุฏู‚ูŠู‚ุŒ ู…ุงุดูŠุŸ ุฃู†ุง ุฑุงุญุช ุตูˆุฑุชูŠ

125
00:12:47,110 --> 00:12:55,240
ุจุตุฑุงุญุฉุŒ ู…ุง ุจุนุฑูุด ุฃูˆูŠุŒ ุจุฏู‡ ุฃุดูˆู ูˆูŠู† ุฃู†ุง ุนุดุงู†โ€ฆ ู…ุง ู‡ูˆ ุงุณู…ู‡ุŸ ุงู„ู…ู‡ู…ุŒ

126
00:12:55,240 --> 00:13:00,320
ุทุจุนุงู‹ ุจุฑุถู‡ ู„ุณู‡ ูŠุนู†ูŠ ูˆุงุถุญุฉ ุงู„ู†ู‚ุทุฉ ุจุงู„ู†ุณุจุฉ ู„ู‡ุงุŒ ุจุณ

127
00:13:00,320 --> 00:13:05,460
ูŠุนู†ูŠ ุจุชู‚ูˆู„ ุฅู†ู‡ ุญุชู‰ ุงู„ุทูุฑุงุช ุงู„ู„ูŠ ุจู‚ุทุนุฉ ูƒุจูŠุฑุฉ ุฒูŠ

128
00:13:05,460 --> 00:13:09,440
ุงู„ู€ Copy Number VariantุŒ ู…ู…ูƒู† ู…ุง ูŠูƒูˆู†ุด ู„ู‡ุง ู‚ูŠู…ุฉ ู„ูˆ

129
00:13:09,440 --> 00:13:15,800
ูƒุงู†ุช ููŠ ุงู„ู€ non-coding regionุŒ ู„ู…ุง ู†ุฎุทุท ุจุงู„ุดูƒู„ ุงู„ุตุญูŠุญ

130
00:13:15,800 --> 00:13:25,530
ุทุจุนุงู‹ุŒ ูˆู‡ุฐู‡ ูŠุนู†ูŠ ู…ู† ุงู„ู€โ€ฆ ู†ุณู…ูŠู‡ุง ู…ู† ุงู„ุธูˆุงู‡ุฑ ุงู„ู„ูŠ ุจุชุนุทูŠ

131
00:13:25,530 --> 00:13:33,050
ุงู„ุฅู†ุณุงู† ุฎุงุตูŠุฉ ุฃูƒุซุฑุŒ ุฅู†ู‡ ุงู„ู€ DNA ุนู†ุฏู‡ ุจูŠุชุญู…ู„ ุฅู†ู‡

132
00:13:33,050 --> 00:13:40,510
ูŠูƒูˆู† ู‡ู†ุงูƒ ุทูุฑุงุช ูƒุซูŠุฑุฉุŒ ุจุณ ุฅุฐุง ููŠ ู…ูƒุงู† ู…ุงู„ูˆุด ู‚ูŠู…ุฉุŒ

133
00:13:40,510 --> 00:13:45,250
ุตุญุŒ ู…ุด ุฑุงุญ ูŠูƒูˆู† ู„ู‡ ู‚ูŠู…ุฉุŒ ุงู„ุฏูƒุชูˆุฑุฉ ุฃุณู…ุงุก ุจุฑุถู‡ ูŠุนู†ูŠ

134
00:13:45,250 --> 00:13:49,610
ุจุชุทู„ุจ ุฅุฐุง ูƒุงู† ููŠู‡ ู…ู…ูƒู† ุดุฑุญ ุงู„ู€ Slide ุฑู‚ู… 7ุŒ ู…ุด ุนุงุฑู

135
00:13:49,610 --> 00:13:53,810
ุฅูŠุด ู‚ุตุฏู‡ุง ููŠ ุงู„ู…ุญุงุถุฑุฉ ู‡ุฐู‡ุŒ ูˆุตู„ุช ุฏูƒุชูˆุฑ ุฃู†ุช ู„ู„ู€ Slide

136
00:13:53,810 --> 00:14:01,650
ุฑู‚ู… 7 ููŠ ุงู„ู…ุญุงุถุฑุฉุŸ ูˆุงู„ู„ู‡ ุงู„ู€ Slide ุฑู‚ู… 7 ุงู„ู„ูŠ ู‡ูˆ

137
00:14:01,650 --> 00:14:03,710
ุงู„ู€ Microarray

138
00:14:06,230 --> 00:14:11,190
ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡ ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

139
00:14:11,190 --> 00:14:12,470
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

140
00:14:12,470 --> 00:14:12,550
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

141
00:14:12,550 --> 00:14:13,290
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

142
00:14:13,290 --> 00:14:14,490
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

143
00:14:14,490 --> 00:14:14,990
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

144
00:14:14,990 --> 00:14:15,050
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

145
00:14:15,050 --> 00:14:23,090
ุจุชูุงุตูŠู„ุŒ ู‡ุฐุง ู…ุง ู†ุฃุฎุฐู‡

146
00:14:23,090 --> 00:14:35,750
ุจุชูุงุตูŠู„

147
00:14:35,860 --> 00:14:42,080
ุงู„ู„ูŠ ุจุชุฏูˆุฑ ุนู„ู‰ ุงู„ุฎู„ู„ ุงู„ู„ูŠ ุฃู†ุง ุจุชูˆู‚ุน ูŠูƒูˆู† ู…ูˆุฌูˆุฏุŒ

148
00:14:42,080 --> 00:14:46,900
ู…ุงุดูŠุŸ ุฑุจู…ุง ู…ุด ู‚ุตุฏู‡ุง ุนู† ุงู„ู€ Slide ู‡ุฐู‡ุŒ ุชู‚ุตุฏ ุงู„ู€ Slide

149
00:14:46,900 --> 00:14:51,300
ุงู„ู„ูŠ ุจุนุฏู‡ุง ูƒู…ุงู†ุŒ ู‡ุฏูˆู„ ู†ูุณ ุงู„ููƒุฑุฉุŒ ูŠุนู†ูŠ

150
00:14:51,300 --> 00:14:55,100
ุงู„ู€ MicroarraysุŒ

151
00:14:55,100 --> 00:15:03,600
ู…ุงุดูŠุŸ ูŠุนู†ูŠ ู‡ู†ุง ุฅุฐุง ุฃู†ุง ู…ุด ูŠุนู†ูŠ ุฃุญูƒูŠ ู„ูƒู… ู‚ุตุตุŒ ู…ุงุดูŠุŸ

152
00:15:04,330 --> 00:15:12,550
ููŠุŒ ุฃู†ุง ุงู„ูุชุฑุฉ ุงู„ุฃุฎูŠุฑุฉุŒ ุงู„ุชู‚ูŠุช ุจุนุงุฆู„ุฉ ู…ู† ุฅุฎูˆุงู†ู†ุง ู…ู†

153
00:15:12,550 --> 00:15:19,530
ุณูˆุฑูŠุงุŒ ู„ุงุฌุฆูŠู† ููŠ ุงู„ุฃุฑุฏู†ุŒ ูŠุนู†ูŠ ูุนู†ุฏู‡ู… ุญุงู„ุฉุŒ ู‡ุฌูŠุจ ู„ูƒู…

154
00:15:19,530 --> 00:15:27,150
ุตูˆุฑุฉ ุฃูŠุฏูŠู‡ู…ุŒ ูˆุฌุฑูŠู‡ู… ู„ู„ู…ุญุงุถุฑุฉ ุงู„ุฌุงูŠุฉุŒ ู…ุงุดูŠุŸ ุนู„ูŠู‡ู… ูŠุนู†ูŠ

155
00:15:27,150 --> 00:15:33,790
ุดูŠุก ุบุฑูŠุจ ุฌุฏุงู‹ุŒ ุฃู‚ุฑุจ ุดูŠุกุŒ ูˆุฅุฐุง ุญุฏุง ุจูŠู†ูƒู… ุจูŠุญุงูˆู„ ูŠุดูˆูู‡

156
00:15:34,230 --> 00:15:41,570
ุงุณู…ู‡ "Infantile Digital Fibromatosis"ุŒ ูŠุนู†ูŠ ุนุจุงุฑุฉ

157
00:15:41,570 --> 00:15:46,930
ุนู†ุŒ ุฎู„ู‘ูŠู†ูŠ ุฃู†ุง ุฃุจุนุช ู„ูƒ ุงู„ุตูˆุฑุฉ ูŠุง ุฏูƒุชูˆุฑ ุฃุญู…ุฏ ุนู„ู‰

158
00:15:46,930 --> 00:15:53,110
ุงู„ู€ WhatsApp ุฅู„ูŠูƒุŒ ู…ุงุดูŠุŸ ุฅู† ุดุงุก ุงู„ู„ู‡ุŒ ูˆู„ู…ุง ุชูŠุฌูŠ

159
00:15:53,110 --> 00:15:59,610
ุฃุนุฑุถู‡ุง ุนู†ุฏูƒ ุจุฅุฐู† ุงู„ู„ู‡ ุชุนุงู„ู‰ุŒ ูู‡ุฏูˆู„ ุงู„ุนุงุฆู„ุฉ ู‡ุฐู‡

160
00:16:00,220 --> 00:16:05,620
ุงู„ูˆุงู„ุฏ ูˆุงู„ูˆุงู„ุฏุฉุŒ ุฏุฑุฌุฉ ุฃูˆู„ู‰ ุฃู‚ุงุฑุจุŒ ูˆู„ุงุฏ ุนู…ุŒ ูˆู„ุงุฏ ุฎุงู„ุฉ

161
00:16:05,620 --> 00:16:11,380
ูŠุนู†ูŠ ููŠู‡ ู‚ุฑุงุจุฉุŒ ูˆุงู„ุดุบู„

162
00:16:11,380 --> 00:16:19,900
ุงู„ุซุงู†ูŠุŒ ุฃู†ู‡ ุนุจุงุฑุฉ ุนู†ุŒ ู‡ู… ุชุณุนุฉ ุฅุฎูˆุฉ ูˆุฅุฎูˆุงุชุŒ ุฃุฑุจุนุฉ

163
00:16:19,900 --> 00:16:29,730
ู…ุตุงุจูŠู†ุŒ ูˆุฃุฑุจุนุฉ ู…ุด ู…ุตุงุจูŠู†ุŒ ู…ุงุดูŠุŸ ูู‡ูŽุจุนุช ู„ูƒ ุงู„ุตูˆุฑ ุฃู†ุช

164
00:16:29,730 --> 00:16:38,410
ุชูุฏุฎู„ู‡ู… ู„ู„ุดุจุงุจ ูˆุงู„ุฏูƒุชูˆุฑุงุชุŒ ูุงู„ุขู†

165
00:16:38,410 --> 00:16:46,330
ุฃู†ุง ุดุงูƒูƒ ุจุดูƒู„ ูƒุจูŠุฑ ุฌุฏุงู‹ ุฃู† ู‡ุฐุง ู…ุฑุถ ูˆุฑุงุซูŠุŒ ูˆุฃุดูƒ ุฃู†ู‡

166
00:16:46,330 --> 00:16:57,390
ูŠุนู†ูŠุŒ ุฅุฐุง ูƒุงู† ู…ู†ุฏูŠู„ูŠุŒ ูŠุนู†ูŠ ูƒุงู† ู†ุงุชุฌ ุนู† ุฎู„ู„ ููŠ ุฌูŠู†

167
00:16:57,390 --> 00:17:04,470
ูˆุงุญุฏุŒ ู…ุงุดูŠุŸ ุจูŠูƒูˆู† autosomal

168
00:17:04,470 --> 00:17:10,030
dominantุŒ ู„ุฃู† ุงู„ุฐูƒูˆุฑ ูˆุงู„ุฅู†ุงุซ ุฒูŠ ุจุนุถุŒ ู…ุง ููŠ ุงุฎุชู„ุงูุงุช

169
00:17:10,030 --> 00:17:20,090
ุจูŠู†ู‡ู…ุŒ ูˆุงู„ุดุบู„ ุงู„ุซุงู†ูŠ ุฃู†ู‡ ุงู„ูƒู„ุŒ ูŠุนู†ูŠ ุงู„ู€โ€ฆ ุงู„ู€โ€ฆ ุงู„ู€โ€ฆ

170
00:17:20,090 --> 00:17:24,390
ุจุงู„ู†ุณุจุฉ ู„ู„ู€โ€ฆ ุฃู†ู‡ ูƒู„ ุงู„ุฃูุฑุงุฏุŒ ูŠุนู†ูŠ ููŠู‡ ุฐูƒูˆุฑ ูˆููŠู‡ู…

171
00:17:24,390 --> 00:17:31,370
ุฅู†ุงุซุŒ ูˆู…ู† ุงู„ุนุงุฆู„ุฉ ุจุงู„ูƒุงู…ู„ุŒ ููŠู‡ ู†ุงุณ ููŠู‡ู… ู…ุตุงุจูŠู†ุŒ ูููŠ

172
00:17:31,370 --> 00:17:38,210
ู…ุซู„ ู‡ูŠูƒ ุญุงู„ุฉุŒ ุดุงูˆุฑุช ู…ุน ู‚ุณู… ุงู„ุฃู…ุฑุงุถ ุงู„ูˆุฑุงุซูŠุฉ ุนู†ุฏู†ุง

173
00:17:39,120 --> 00:17:47,020
ุงู„ู…ุดูƒู„ุฉ ุฃู†ู‡ ุฃู†ุง ู…ุง ุนู†ุฏูŠ ุชุฎูŠู„ ุณุงุจู‚ุŒ ู„ูˆูŠู† ุฃู†ูˆู„ ุงู„ุฌูŠู†

174
00:17:47,020

223
00:22:20,420 --> 00:22:29,180
ุงู„ุซุงู†ูŠ ุงู„ู„ูŠ ุตุงุฑ ุญุฌู…ู‡ ุฃูƒุจุฑ ูู‡ุฐู‡ ุงู„ุธุงู‡ุฑุฉ ู‡ูŠ ุชุณู…ู‰ ุงู„ู€

224
00:22:29,180 --> 00:22:36,810
Balanced Translocation ูŠุนู†ูŠ ุงุฎุชู„ุงู„ ููŠ ู…ูƒุงู† ุงู„ู‚ุทุนุฉ

225
00:22:36,810 --> 00:22:46,170
ุงู„ูƒุจูŠุฑุฉ ุจุญูŠุซ ุฃู†ู‡ ุจุงู„ู…ุญุตู„ุฉ ุงู„ู…ุงุฏุฉ ุงู„ูˆุฑุงุซูŠุฉ ุชุจุน ู‡ุฐุง

226
00:22:46,170 --> 00:22:52,550
ุงู„ุฅู†ุณุงู† ุจุชูƒูˆู† ูƒุงู…ู„ุฉุŒ ุจุชูƒูˆู† ุทุจูŠุนูŠุฉุŒ ุงู„ู€Total ุทุจูŠุนูŠุŒ

227
00:22:52,550 --> 00:23:01,890
ุจุณ ู…ูƒุงู†ู‡ ุบู„ุทุŒ ูู„ู…ุง ูŠูƒูˆู† ูˆุฌูˆุฏ Balanced Translocation

228
00:23:01,890 --> 00:23:11,630
ู…ุงุดูŠุŒ ู‡ุฐู‡ ุจุชูƒูˆู† ู†ุชูŠุฌุชู‡ุง ุฃู† ู†ูุณ ุงู„ุดุฎุต ู‡ุฐุง ุจูŠูƒูˆู† ุทุจูŠุนูŠ

229
00:23:11,630 --> 00:23:19,670
ุจุณ ุฃู†ู‡ ุจุงู„ู†ุณุจุฉ ู„ู„ู€ ุจุฑูˆุฌูŠู†ูŠุชู‡ุŒ ูˆู„ุงุฏู‡ ูˆุจู†ุงุชู‡

230
00:23:19,670 --> 00:23:26,450
ุจุนุฏูŠู† ุฑุงุญ ุชุตูŠุฑ ููŠู‡ ุฅุดูƒุงู„ูŠุงุชุŒ ุฃู†ู‡ ู„ู…ุง ูŠุตูŠุฑ ุงู„ุฎู„ุงูŠุง

231
00:23:26,450 --> 00:23:30,050
ุงู„ู…ุทู„ูˆุจุฉ ู…ู†ู‡ุง ุชู†ู‚ุต ุจุดูƒู„ ุณู„ูŠู…ุŒ ููŠ ุจุนุถ ุงู„ุฎู„ุงูŠุง ุฑุงุญ

232
00:23:30,050 --> 00:23:36,530
ุชูƒูˆู† ุนู†ุฏู‡ุง DNA ู†ุงู‚ุตุŒ ูˆูŠู…ูƒู† ู‡ุฐุง ูŠูƒูˆู† ุบูŠุฑ ุญูŠ ูˆู„ุง ูŠุนูŠุด

233
00:23:36,530 --> 00:23:41,250
ูˆุฅู†ู‡ ูŠูƒูˆู† ููŠู‡ ุฅูŠุด ุฒุงูŠุฏุŒ ูŠูƒูˆู† ูŠุนุทูŠู†ุง ู…ุฑุถ. ู‡ุงูŠ ู‚ุถูŠุฉ

234
00:23:41,250 --> 00:23:45,610
ุงู„ู€ Structural AbnormalitiesุŒ ูˆู‡ู…ูŠุฉ ุฃู† ุชูƒูˆู† Balanced

235
00:23:45,610 --> 00:23:50,470
ุฃูˆ UnbalancedุŒ ูˆูƒูŠู ุชุฃุซูŠุฑู‡ุง. ุงู„ุดุบู„ ุงู„ุซุงู†ูŠ ุงู„ู€

236
00:23:50,470 --> 00:23:56,610
Unbalanced ูŠุนู†ูŠ ุงุฎุชู„ุงู„ ุนุฏุฏ ู†ุณุฎ ูˆูƒู…ูŠุฉ

237
00:23:56,610 --> 00:24:01,550
ุงู„ู€ Chromosomes ุงู„ู„ูŠ ู‡ูŠ ุฑุงุญ ู†ุญูƒูŠ ุนู†ู‡ุงุŒ ุนู…ู„ูŠุฉ ุนุฏู…

238
00:24:01,550 --> 00:24:07,710
ุงู†ุตุงู„ ุงู„ู€ Chromosomes ุนู† ุจุนุถ ุจุดูƒู„ ุณู„ูŠู…ุŒ ูˆุจุงู„ุฐุงุช ู‡ูŠ

239
00:24:07,710 --> 00:24:11,930
ุฃูƒุซุฑ ู„ู„ู€ XY-ChromosomeุŒ ุจุณ ู…ู…ูƒู† ุญุชู‰ ููŠ

240
00:24:11,930 --> 00:24:17,690
ุงู„ู€ Chromosomes ุงู„ุซุงู†ูŠุฉ. ููŠ ุฃุณุฆู„ุฉ ู‡ู†ุงุŸ

241
00:24:17,690 --> 00:24:24,450
ู„ูŠุณุชุฉ ุฃุฑุฌูˆ ุฃู†ูƒู… ุชุญูุธูˆู‡ุง. ูŠุนู†ูŠ ู„ู…ุง ุชูŠุฌูŠ ุชู‚ุฑุฃุŒ ูˆุจุนุฏูŠู†

242
00:24:27,860 --> 00:24:35,400
ุงู„ุชู‚ุงุฑูŠุฑ ุนู† ุฃูŠ ู…ุฑุถ ูˆุชุญุงูˆู„ูˆุง ุชูู‡ู…ูˆุง ุดูˆ ุงู„ู„ูŠ ุจูŠุญูƒูˆุง

243
00:24:35,400 --> 00:24:40,060
ุนู†ู‡ ูƒุญุฏุซ ุงู„ู„ูŠ ุญุตู„ ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ู…ุงุฏุฉ ุงู„ูˆุฑุงุซูŠุฉ ูˆุงู„ู€

244
00:24:40,060 --> 00:24:47,180
DNAุŒ ูˆูƒูŠู ุตุงุฑ. ูุฅุฐุง ูƒุชุจูˆุง ุงู„ุฏูŠู„ "Deletion"ุŒ ุฅุฐุง ูƒุงู†

245
00:24:47,180 --> 00:24:51,540
ุญุงุทูŠู† ุฅุดุงุฑุฉ ุฒุงุฆุฏุŒ ูุฅู†ู‡ ุตุงุฑ ุฒูŠุงุฏุฉ ููŠ ุงู„ูˆุธูŠูุฉ ุฃูˆ

246
00:24:51,540 --> 00:24:58,120
ู†ู‚ุตุงู† ููŠ ุงู„ูˆุธูŠูุฉุŒ ุฃูˆ ู‡ู†ุงูƒ ูŠุนู†ูŠ ููŠ ู†ูุณ ุงู„ุฌุณู… ุฎู„ุงูŠุง

247
00:24:58,120 --> 00:25:02,560
ุจุชูƒูˆู† ุจุดูƒู„ุŒ ูˆุฎู„ุงูŠุง ุซุงู†ูŠุฉ ุจุชูƒูˆู† ุจุดูƒู„ ุขุฎุฑุŒ ุฅู†ู‡ ุจูŠูƒูˆู†

248
00:25:02,560 --> 00:25:09,020
ูุนู„ุงู‹ ู…ูˆุฒุงุฆูŠูƒุฒู…ุŒ ู…ูˆุฒุงุฆูŠูƒ ู…ุงุดูŠุŒ ุงู„ู„ูŠ ู‡ูŠ ุฅู†ู‡ ูŠุนู†ูŠ ุฒูŠ ุงู„ู€

249
00:25:11,210 --> 00:25:16,310
ุงู„ุฃู†ุธู…ุฉ ุฃูˆ ุงู„ุดูƒู„ุŒ ุฅู†ู‡ ุจูŠูƒูˆู† ู…ู† ุฃูƒุซุฑ ู…ู† ู†ูˆุนุŒ ู…ุซู„ุงู‹ ู…ู†

250
00:25:16,310 --> 00:25:21,990
ุจู„ุงุท ู„ูˆู† ู…ุนูŠู† ูˆุจู„ุงุท ู„ูˆู† ุซุงู†ูŠ ู…ุซู„ุงู‹. ู‚ุถูŠุฉ ุงู„ู€

251
00:25:21,990 --> 00:25:26,550
TranslocationุŒ ุฑูˆุจุฑุชุณูˆู†ูŠุงู† TranslocationุŒ Rain

252
00:25:26,550 --> 00:25:30,890
Chromosome. ูŠุนู†ูŠ ุงู„ุฃุดูŠุงุก ุงู„ู„ูŠ ู…ูˆุฌูˆุฏุฉ ู‡ุฐู‡ุŒ ุฌุฏูˆู„

253
00:25:32,000 --> 00:25:39,080
ูƒู…ุตุทู„ุญุงุชุŒ ู„ุฃ ู…ู‡ู…ุŒ ูˆูƒูˆูŠุณ ุงู„ูˆุงุญุฏ ูŠูู‡ู…ู‡ุŒ ุนุดุงู† ู„ู…ุง ู†ู‚ุฑุฃ

254
00:25:39,080 --> 00:25:45,260
ูŠุนู†ูŠ ู‡ู†ุง ูƒู…ุซุงู„ุŒ ู„ูƒู„ ูˆุงุญุฏ ู…ู†ู‡ู… ุดูˆ ู…ุนู†ุงู‡ุŒ ูˆุดูˆ ุจูŠุฏู„ ุนู„ู‰

255
00:25:45,260 --> 00:25:54,580
ุฅูŠุดุŒ ุฃู† ู†ูƒูˆู† ุจุฐู„ูƒ ุงู„ุดูƒู„. ู‡ุงูŠ ูƒู…ุงู† ูŠุนู†ูŠ ุฃุณู„ูˆุจุŒ ูŠุนู†ูŠ

256
00:25:54,580 --> 00:26:03,070
ู„ู…ุง ูŠุญุทูˆุง ู„ู†ุง ุฑุณู…ุงุช ุฒูŠ ู‡ูŠูƒุŒ ู…ุงุดูŠุŒ ู‡ูˆ ุจูŠุญุท ู†ู…ุงุฐุฌ ู…ุฎุชู„ูุฉ

257
00:26:03,070 --> 00:26:11,750
ู„ู„ุชุฌุงุฑุจ ุงู„ู…ุฎุจุฑูŠุฉุŒ ู„ุชุดุฎูŠุต ู‡ุฐู‡ ุงู„ุญุงู„ุฉ. ูุงู„ู€ Trisomy 21

258
00:26:11,750 --> 00:26:19,170
ุงู„ู„ูŠ ู‡ูˆ Down SyndromeุŒ ู…ุงุดูŠ. ุงู„ู€ Trisomy 21 ู…ู…ูƒู†

259
00:26:19,170 --> 00:26:25,690
ุฃู†ุง ููŠ ุงู„ู€ A ุญุทูŠุช ุงู„ู„ูŠ ู‡ูˆ KaryotypeุŒ ูุฃู†ุง ุจุดุบู„ู‡

260
00:26:25,690 --> 00:26:33,220
ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ู‡ุฐู‡ ูƒุฑูŠูˆุชูŠุจุŒ ูˆุจูŠูƒูˆู† ููŠู‡ ุชุฑุงูŠุณูˆู…ูŠ 21ุŒ ู…ู…ูƒู† ุฃู†ุง

261
00:26:33,220 --> 00:26:39,280
ุฃุณุชุฎุฏู… ุงู„ู€ Fluorescence in situ hybridizationุŒ ุงู„ู„ูŠ ู‡ูŠ Fluorescence

262
00:26:39,280 --> 00:26:45,720
in situ Hybridization for Chromosome 21ุŒ ูˆูŠุนู†ูŠ ู‡ู†ุง

263
00:26:45,720 --> 00:26:51,360
ุจูŠุทู„ุน ู„ูŠู‡ุŒ ุฅู† ุฃู†ุง ุนู†ุฏูŠ ุชู„ุช ู†ุณุฎุฉุŒ ู…ุงุดูŠุŒ ูŠุนู†ูŠ ูŠู…ูƒู† ู‡ูˆ

264
00:26:51,360 --> 00:26:56,960
ุงู„ุฃุญู…ุฑุŒ ูุจูƒูˆู† ุฅู†ู‡ ููŠ ู‡ุฐู‡ ุงู„ุฎู„ูŠุฉ ุจูŠูƒูˆู† ุนู†ุฏูŠ ุซู„ุงุซ ู†ุณุฎ

265
00:26:56,960 --> 00:27:00,980
ู…ู† ู‡ุฐุง ุงู„ุฃุญู…ุฑ. ูƒุฑูˆู…ูˆุฒูˆู… ุซุงู†ูŠุŒ ุนุดุงู† ุฃุชุฃูƒุฏ ุฅู† ุฃู†ุง ุดุบู„ูŠ

266
00:27:00,980 --> 00:27:07,700
ู…ุธุจูˆุทุŒ ุฎุทูŠุช ุนู„ูŠู‡ ุตุจุบุฉ ุฎุถุฑุงุกุŒ ูˆุจุงู„ุชุงู„ูŠ ุจูŠู† ุนู†ุฏูŠ ุฅู†

267
00:27:07,700 --> 00:27:12,520
ุฃู†ุง ููŠ ู†ุณุฎุชูŠู†. ุฃู†ุง ู…ุดุŒ ุฃู†ุง ุจุงู„ุบู„ุท ุตุงุฑ Overlap ุจูŠู†

268
00:27:12,520 --> 00:27:18,440
ุฎู„ูŠุชูŠู†ุŒ ูˆููŠ ุญุงู„ุฉ ุฅู†ู‡ ุนู†ุฏูŠ ุฃู†ุง ุฃูƒุซุฑ ู…ู† ู†ุตูุŒ ูŠุนู†ูŠ

269
00:27:18,440 --> 00:27:24,850
ู…ู† ุฒูŠุงุฏุฉ ู…ู† ุฎู„ูŠุฉ ุฃูƒุซุฑ ู…ู† ุฎู„ูŠุฉ. ูู‡ู†ุงุŒ ู‡ุงูŠ ู†ูˆุน ู…ู† ุงู„ู€

270
00:27:24,850 --> 00:27:29,250
FISHุŒ ุงู„ู„ูŠ ู‡ูˆ in situ HybridizationุŒ ุจู†ุณุชุฎุฏู… ุชู‚ู†ูŠุงุช

271
00:27:29,250 --> 00:27:36,350
ู…ุฎุชู„ูุฉ. ุงู„ู„ูŠ ุจุนุฏู‡ุงุŒ ุงู„ู„ูŠ ุฏู„ูˆู‚ุช ูŠู‚ุฑุง ุงู„ู„ูŠ ู‡ูˆ

272
00:27:36,350 --> 00:27:39,470
Chromosomal

273
00:27:39,470 --> 00:27:44,750
Microarray ูˆุงุณุชุฎุฏุงู…

274
00:27:44,750 --> 00:27:49,790
ูŠุนู†ูŠ ุงู„ู„ูŠ ู‡ูˆ ุงู„ู€ MicroarraysุŒ ุงู„ู„ูŠ ู‡ูŠ ุงู„ุฃุณู„ูˆุจ ุงู„ุซุงู„ุซ

275
00:27:51,810 --> 00:28:00,170
ุจุดูˆู ู‡ู†ุง ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุช ุชุจุน ุงู„ุฅู†ุณุงู†ุŒ ูˆุงู„ุฃุตู„ ุงู„ู„ูŠ ู‡ูŠ

276
00:28:00,170 --> 00:28:07,530
2MุŒ ูŠุนู†ูŠ ุงู„ู†ุณุฎุชูŠู† ู…ู† ุงู„ู€ ู…ู† ุงู„ู€ ุงู„ู€ DNAุŒ ูˆู„ุง

277
00:28:07,530 --> 00:28:11,930
ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุŒ ุจุชูƒูˆู† ููŠ ู‡ุฐุง ุงู„ู†ุทุงู‚. ุญุณุจ ู‡ุฐุง ุงู„ุจุญุซุŒ ุจู„ุงู‚ูŠ

278
00:28:11,930 --> 00:28:19,430
ู‡ู†ุง ุงู„ูƒุฑูˆู…ูˆุฒูˆู… 21 ุนุงู„ูŠ ูƒุซูŠุฑุŒ ูˆุนุฑูุช ุฃู†ู‡ ูŠุนู†ูŠ ุซู„ุงุซ ู†ุณุฎ

279
00:28:19,430 --> 00:28:24,570
ุจุฏู„ ู…ุง ู‡ูˆ ู…ู† ู†ุณุฎุชูŠู†ุŒ ุงู„ุนุงุฏูŠ. ู„ูˆ ูƒุงู† ููŠู‡ ู…ุซู„ุงู‹ ู†ูุชุฑุถ

280
00:28:24,570 --> 00:28:30,810
ุฃู†ุง ุดุฎุต ุจู€ "ุชูŠุฑู†ุฑ ุณู†ุฏุฑูˆู…"ุŒ ู…ุง ุจุชุนุฑููˆุง ุนู†ู‡ุŒ ุจูŠูƒูˆู† XO

281
00:28:30,810 --> 00:28:34,610
ุจูŠูƒูˆู† "one copy of X". ุจุงุฌูŠ ู„ูˆ ุจุงุฌูŠ ุจุนู…ู„

282
00:28:34,610 --> 00:28:38,410
ุงู„ู€ microarray ู‡ุฐุงุŒ ุจุงุณุชุฎุฏู…ู‡ ู„ู„ู€ X-ChromosomeุŒ ูƒุงู†

283
00:28:38,410 --> 00:28:43,580
ุจู„ุงู‚ูŠ ุงู„ุทูู„ ู‡ุฐุง ุฃูˆ ุงู„ุฅู†ุณุงู† ู‡ุฐุงุŒ ุจูŠุฌูŠ ุจุฑูˆุญุŒ ุจุชู„ุงู‚ูŠ ุฅุฐุง

284
00:28:43,580 --> 00:28:47,720
ูƒุงู† ููˆู‚ ู…ุนู†ุงุชู‡ ุฒูŠุงุฏุฉุŒ ุฅุฐุง ูƒุงู† ุชุญุช ู…ุนู†ุงุชู‡ ููŠู‡ ู†ู‚ุต

285
00:28:47,720 --> 00:28:55,960
ูู‡ูŠ ุงู„ููƒุฑุฉ ู‡ู†ุง ูƒู„ู‡ ู„ู†ูุณ ุงู„ุชุดุฎูŠุตุŒ ู„ู†ูุณ ุงู„ุธุงู‡ุฑุฉุŒ ูˆู„ูƒู†

286
00:28:55,960 --> 00:29:03,680
ุจุงุณุชุฎุฏุงู… ูˆุณุงุฆู„ ู…ุฎุจุฑูŠุฉ ู…ุฎุชู„ูุฉ. ูŠุนู†ูŠ ูƒู„ ูˆุงุญุฏ ู…ู†ู‡ู… ุฅูŠู‡

287
00:29:03,680 --> 00:29:07,900
ุฅูŠุฌุงุจูŠุงุชู‡ ูˆุฅูŠู‡ ุณู„ุจูŠุงุชู‡ุŒ ุฅูŠู‡ ู†ู‚ุงุท ู‚ูˆุชู‡ุŒ ุจุณ ููŠู‡ ุฅูŠู‡ ู†ู‚ุงุท

288
00:29:07,900 --> 00:29:12,680
ุถุนู. ุถุฑูˆุฑูŠ ุงู„ูˆุงุญุฏ ูŠู†ุชุจู‡ ู„ู‡ุฐู‡ ุงู„ุฃุดูŠุงุกุŒ ู„ู…ุง ูŠููƒุฑ ูƒูŠู

289
00:29:12,680 --> 00:29:22,480
ูŠุดุฎุต ู‡ุฐู‡ ุงู„ุญุงู„ุฉ. ููŠ ุฃุณุฆู„ุฉุŸ ู„ุฃู† ู†ูˆุนูŠุงุช ุงู„ู€

290
00:29:22,480 --> 00:29:29,920
Translocation ูˆุฃู†ูˆุงุนู‡ุงุŒ Balanced ูˆ UnbalancedุŒ ูˆุจูƒูˆู†

291
00:29:29,920 --> 00:29:37,380
ููŠุŒ ูˆู…ูƒุงู† ุจูŠู† ูƒุฐุง ูˆูƒุฐุง. ูŠุนู†ูŠ ู‡ุฐู‡ ุงู„ุธูˆุงู‡ุฑ ุชุญุฏุซ

292
00:29:38,300 --> 00:29:45,240
ููŠู‡ ุธูˆุงู‡ุฑ ู…ูˆุฌูˆุฏุฉุŒ ูˆุฃุญูŠุงู†ู‹ุง ูŠุนู†ูŠ ููŠ ุญุงู„ุงุช ู…ุนูŠู†ุฉ

293
00:29:45,240 --> 00:29:52,440
ุจูŠูƒูˆู† ููŠู‡ุง ุญุชู‰ ุฏูˆุฑ ูˆุธูŠููŠ ู„ู„ู…ุฑุถ ุงู„ู„ูŠ ุจู†ุดูˆูู‡

294
00:29:52,440 --> 00:29:59,660
ูŠุนู†ูŠ ู…ุซู„ุงู‹ ุงู„ู…ุฑุถ ู…ู† ุฃู†ูˆุงุน ุงู„ุณุฑุทุงู†ุงุช ุงู„ู„ูŠ ู‡ูˆ

295
00:29:59,660 --> 00:30:06,260
"Chronic Myeloid Leukemia"ุŒ ุงู„ู€ "CML". ุงู„ู€ "CML" ู…ู†

296
00:30:06,260 --> 00:30:10,750
ุงู„ุฃุดูŠุงุก ุงู„ู…ู…ูŠุฒุฉ ู„ู‡ุŒ ุงู„ู„ูŠ ู‡ูŠ ู…ูˆุถูˆุน ุจูŠุณู…ูˆู‡ ุงู„ู€

297
00:30:10,750 --> 00:30:13,750
Philadelphia chromosomeุŒ ุงู„ู€ Philadelphia

298
00:30:13,750 --> 00:30:19,630
chromosomeุŒ ุนุจุงุฑุฉ ุนู† Translocation

299
00:30:19,630 --> 00:30:27,330
ุจูŠู† ู‚ุทุนุชูŠู† ู…ู† ุงู„ู€ DNAุŒ ุจุญูŠุซ ุฃู†ู‡ ููŠ ุงู„ู€ PCR ุงู„ู„ูŠ ู‡ูˆ

300
00:30:27,330 --> 00:30:32,570
ุงู„ู€ B cell receptor geneุŒ ูŠุนู†ูŠ ุนุจุงุฑุฉ ุนู† ู…ูƒุงู† ู…ุนูŠู†

301
00:30:32,570 --> 00:30:37,230
ููŠ ุงู„ุฎู„ุงูŠุง ุงู„ู„ูŠู…ูุงูˆูŠุฉ. ุงู„ุฎู„ุงูŠุง ุงู„ู„ูŠู…ูุงูˆูŠุฉุŒ ุจุณ ุฅู„ู‡

302
00:30:37,230 --> 00:30:44,600
ุฏุฎู„ ููŠ ุจู‚ุงุก ุงู„ุฎู„ุงูŠุง ูˆู…ุนูŠุดุฉ ุงู„ุฎู„ุงูŠุง ูˆุญูŠุงุฉ ุงู„ุฎู„ุงูŠุง

303
00:30:44,600 --> 00:30:51,340
ู…ู†ุนู‡ุง ู…ู† ุฅู†ู‡ุง ุชุชูˆูู‰ ุจุงู„ู€ ApoptosisุŒ ูˆููŠ ุงู„ู€ ABL-Gene

304
00:30:51,340 --> 00:30:56,020
ุงู„ู„ูŠ ุฏุฎู„ ููŠ ุงู„ู€ Longevity ุชุจุนุชู‡. ูู‡ุฏูˆู„ ุงู„ุฃุตู„ ู‚ุทุนุชูŠู†

305
00:30:56,020 --> 00:30:59,840
ููŠ ุงู„ู€ DNAุŒ ุจุนุงุฏ ุนู† ุจุนุถุŒ ูˆู„ู…ุง ูŠูŠุฌูŠ ููŠ ุงู„ู€

306
00:30:59,840 --> 00:31:02,340
Philadelphia chromosomeุŒ ุฃูˆ ููŠ ุงู„ู„ูŠ ุนู†ุฏู‡ู… ู‡ุฐู‡ ุงู„ู€

307
00:31:02,340 --> 00:31:06,440
Genetic MutationุŒ ุจูŠุตูŠุฑูˆุง ุฌุงู†ุจ ุจุนุถุŒ ูˆุจูƒูˆู† ู†ุชูŠุฌุฉ

308
00:31:06,440 --> 00:31:13,110
ุงุฎุชู„ุงู„ ููŠ ูˆุธูŠูุฉ ุงู„ุฎู„ูŠุฉ. ูู‡ุฐู‡ ูƒู„ู‡ุง ุธูˆุงู‡ุฑุŒ ูŠุนู†ูŠ ุฃู†ุง ุฃุธู†

309
00:31:13,110 --> 00:31:22,750
ุฃู†ู‡ ุงู„ุขู† ุงู„ู…ุทู„ูˆุจ ุงู„ูู‡ู… ุงู„ุนุงู…ุŒ ูˆู„ูŠุณ ุงู„ู…ู‚ุตูˆุฏ ุงู„ุชูุงุตูŠู„

310
00:31:22,750 --> 00:31:28,950
ุญุฏูˆุซ ู‡ุฐู‡ ุงู„ุฃุดูŠุงุกุŒ ู„ู…ุง ูŠูƒูˆู† ุงู„ู€ Translocation

311
00:31:28,950 --> 00:31:35,390
ูˆุงู„ุงุฎุชู„ุงู„. ุฏู„ูˆู‚ุชูŠ ุจู‚ูˆู„ู‡ BalancedุŒ ุงู„ุจู„ุงุก ุฃู‚ู„ุŒ ุงู„ู…ุฑุถ

312
00:31:35,390 --> 00:31:42,330
ุฃุฎูุŒ ุฅู†ู‡ ุนู„ู‰ ุงู„ุฃู‚ู„ ู‡ุฐุง ุงู„ุฅู†ุณุงู† ุนู†ุฏู‡ ูƒู…ูŠุฉ DNA ูƒุงููŠุฉ

313
00:31:42,330 --> 00:31:49,470
ูˆุทุจูŠุนูŠุฉ ูˆู…ุชูˆู‚ุนุฉุŒ ุจุณ ูˆูŠู† ุชูˆุงุฌุฏู‡ุงุŒ ุดุฑุท ุชู„ุชุญู… ู…ุน ุจุนุถ

314
00:31:49,470 --> 00:31:54,670
ูƒูŠู ุนู„ุงู‚ุชู‡ุง ููŠ ุจุนุถุŒ ู‡ูˆ ุงู„ู„ูŠ ุจูŠุตูŠุฑ ููŠู‡ ุฎู„ุงูุงุชุŒ ูˆู‡ุฐู‡ ุฑุงุญ

315
00:31:54,670 --> 00:31:58,450
ุชู†ุชุฌ ุนู†ุฏู‡ุง ู…ุดุงูƒู„ ููŠ ุงู„ุฐุฑูŠุฉ ุชุจุน ู‡ุฐุง ุงู„ุฅู†ุณุงู†ุŒ ููŠ

316
00:31:58,450 --> 00:32:07,590
ูˆู„ุงุฏู‡ ูˆุจู†ุงุชู‡. ู‡ู†ุง ุฏุฑุงุณุฉุŒ ูŠุนู†ูŠ ู…ู‡ู… ุงู„ูˆุงุญุฏ ูŠุชุทู„ุน

317
00:32:07,590 --> 00:32:15,450
ุนู„ูŠู‡ุงุŒ ูˆูŠูƒูˆู† ูŠุชุฎูŠู„ู‡ุงุŒ ุนู„ู‰ ู†ุณุจุฉ ุงุญุชู…ุงู„ุงุช ุงู„ุฃู…ุฑุงุถ

318
00:32:15,450 --> 00:32:22,210
ุงู„ูˆุฑุงุซูŠุฉุŒ ุงู„ู„ูŠ ู‡ูŠ ุงู„ู€ Whole Genome ุฃูˆ Whole

319
00:32:22,210 --> 00:32:26,490
Chromosome ุงู„ุฏุฑุงุณุฉ

320
00:32:26,490 --> 00:32:33,010
ู‡ุฐู‡ ุนู„ู‰ 10,000 ุญุงู„ุฉ ูˆู„ุงุฏุฉุŒ ู…ุงุดูŠุŸ

321
00:32:36,020 --> 00:32:40,660
ูˆูŠุนู†ูŠ ุญุงุทูŠู† ู‡ู†ุงุŒ ุฒูŠ ู…ุง ุฐูƒุฑุชุŒ ุฃูƒุซุฑ ุดูˆูŠุฉ ู…ู† ุงู„ู…ุฑุฉ ุงู„ู„ูŠ

322
00:32:40,660 --> 00:32:45,360
ูุงุชุชุŒ ุงู„ู€ Spontaneous Abortion ูˆุงู„ู€ Live Born

323
00:32:45,360 --> 00:32:52,380
Infant. ูŠุนู†ูŠ ุงู„ุฅุซู†ูŠู†ุŒ ู„ูˆ ุตุงุฑ AbortionุŒ ุจูŠู‚ุถูˆุง ูŠุฏุฑุณูˆุง

324
00:32:52,380 --> 00:32:56,340
ูƒูŠู ูˆุถุน ุงู„ู€ KaryotypeุŒ ุดูˆ ุงู„ู„ูŠ ู†ูˆุน ุงู„ู…ุดูƒู„ุฉ

325
00:32:56,340 --> 00:33:03,700
ุงู„ู…ูˆุฌูˆุฏุฉุŒ ุฃูˆ ุญุฏูˆุซ ุฅุฌู‡ุงุถ ุฐุงุชูŠ

326
00:33:03,700 --> 00:33:08,520
spontaneousุŒ ุงู„ุขู†

327
00:33:08,520 --> 00:33:13,480
ู†ุดูˆู ูƒู… ู†ุณุจ ุงู„ุงุฎุชู„ุงู„ุงุช ููŠ ุงู„ู€ Chromosomes ูƒู„ู‡ุง

328
00:33:13,480 --> 00:33:20,020
ูู‡ู†ุง ุฃู†ุง ุงุณุชุฎุฏู…ุช ุงู„ู„ูŠ ู‡ูˆ ุจูŠู† ู‚ูˆุณูŠู† ุงู„ู€ Karyotype

329
00:33:20,020 --> 00:33:28,340
ูŠุนู†ูŠ ุญุชู‰ ุฃุทู„ุน ู…ุซู„ ุฅูŠู‡ ู†ุชุงุฌ ุงู„ุญุงู„ุงุช

330
00:33:28,340 --> 00:33:33,440
ุงู„ู„ูŠ ุนู…ู„ูˆู‡ุง ุงู„ุฏุฑุงุณุฉ ู‡ุฐู‡ุŒ ุงู„ุนุดุฑ ุขู„ุงูุŒ ูƒุงู† 1500

331
00:33:33,440 --> 00:33:40,940
abortionุŒ 15%ุŒ ูˆ8500 ูŠุนู†ูŠ 85% live birth

332
00:33:44,320 --> 00:33:50,120
ุจุงู„ู†ุณุจุฉ ู„ู„ู€ Live Births ู…ู† ุงู„ู€ 8500ุŒ ููŠู‡ ุฎู…ุณูŠู† ูƒุงู†

333
00:33:50,120 --> 00:33:54,220
ุนู†ุฏู‡ู… ูƒุฑูˆู…ูˆุฒูˆู… AnomalousุŒ ุจูŠู†ู…ุง ุจุงู„ู€

334
00:33:54,220 --> 00:34:00,660
Spontaneous AbortionsุŒ 750 ู…ู† ุงู„ู€ 1500 ูƒุงู† ุนู†ุฏู‡ู…

335
00:34:00,660 --> 00:34:09,880
Abnormal Chromosome. ูŠุนู†ูŠ ุจุงู„ุฐุงุช ููŠ ุนู†ุฏ ุญุฏูˆุซ

336
00:34:09,880 --> 00:34:16,500
ุงู„ุฅุฌู‡ุงุถ ุงู„ุฐุงุชูŠ ู„ู„ู…ุฑุฃุฉ ุงู„ุญุงู…ู„ุŒ ููŠ ุงู„ุฃุดู‡ุฑ ุงู„ุฃูˆู„ู‰ุŒ ู†ุชูƒู„ู…

337
00:34:16,500 --> 00:34:22,220
ุญุชู‰ ุบุงู„ุจู‹ุง ุฃูˆู„ ุซู„ุงุซ ุฃุดู‡ุฑุŒ ู‡ุฐู‡ ุฑุงุญ ูŠูƒูˆู† ููŠ ุงู„ุบุงู„ุจ ููŠ

338
00:34:22,220 --> 00:34:29,720
ุฃู†ู‡ุง Abnormal chromosomal defectุŒ ูŠุนู†ูŠ ู…ุดูƒู„ุฉ ูƒุจูŠุฑุฉ

339
00:34:29,720 --> 00:34:36,880
ุจุงู„ู†ุณุจุฉ ู„ูƒู…ูŠุฉ ูƒุจูŠุฑุฉ ู…ู† ุงู„ู€ DNAุŒ ูˆู‡ุฐู‡ ูŠุนู†ูŠ ุญุชู‰ ู„ูˆ

340
00:34:36,880 --> 00:34:42,920
ุตุงุฑ Live birthุŒ ู…ู…ูƒู† ุฃุญูŠุงู†ู‹ุง ูŠูƒูˆู† ููŠ ู†ุณุจุฉ ู…ู† ุฃู…ุฑุงุถ

341
00:34:42,920 --> 00:34:48,940
ู…ุซู„ ุฐู„ูƒ. ุงู„ุขู†ุŒ ู…ุง ู‡ูŠ ุฃู†ูˆุงุน ุงู„ู…ุดุงูƒู„ ุงู„ู„ูŠ ุจุชูˆู‚ุน ุงู„ูˆุงุญุฏ

342
00:34:48,940 --> 00:34:54,020
ุฃูˆ ุงู„ู„ูŠ ู„ู‚ูˆู‡ุง ููŠ ุงู„ุฏุฑุงุณุฉุŸ

343
00:34:54,020 --> 00:35:01,740
ูŠุนู†ูŠุŒ ู…ุน ุงู„ู€ AbortionุŒ 800 ุญุงู„ุฉ Total ู…ู† ุงู„ู€ 10,000

344
00:35:01,740 --> 00:35:06,620
pregnanciesุŒ ูŠุนู†ูŠ 8% ูƒุงู† ููŠู‡ู… ุงู„ู€ Chromosomal

345
00:35:06,620 --> 00:35:11,040
Anomalies. ูŠุนู†ูŠ ู†ุณุจุฉ ู…ุญุฑุฒุฉ ููŠู‡ Triploid ูˆ

346
00:35:11,040 --> 00:35:17,180
Tetraploid. ูŠุนู†ูŠ ุฅุญู†ุง ุงู„ุฃุตู„ ู„ู„ุฅู†ุณุงู† ุฅู† ุงู„ุฎู„ุงูŠุง

347
00:35:17,180 --> 00:35:26,440
ุงู„ุชุงุจุนุฉ ู„ู†ุง ููŠู‡ุง 46ุŒ ุฒูˆุฌ ู…ุงุดูŠุŒ ูŠุนู†ูŠ 23 ุฒูˆุฌุŒ 46

348
00:35:26,440 --> 00:35:38,780
ูƒุฑูˆู…ูˆุฒูˆู…. ุงู„ู€ Triploid ูŠุนู†ูŠ ูŠุทู„ุน ุงู„ู„ูŠ ู‡ูˆ 23ร—3

349
00:35:38,780 --> 00:35:46,270
ุจูŠุตูŠุฑ ุฅู†ู‡ุง 69 ูƒุฑูˆู…ูˆุฒูˆู…ุŒ ุจุญูŠุซ ุฃู†ู‡ ูŠูƒูˆู† ุซู„ุงุซ ู†ุณุฎ

350
00:35:46,270 --> 00:35:51,970
ูˆTetraploid ูŠุนู†ูŠ ุฃู†ู‡ ุถุฑุจ ุจุฃุฑุจุนุฉุŒ 23ร—4

351
00:35:51,970 --> 00:35:59,170
ูŠุนู†ูŠ ุจูŠุตูŠุฑ 92 chromosome ู…ูˆุฌูˆุฏ ููŠ ุงู„ุฎู„ุงูŠุงุŒ ูู‡ูŠ ุญุฏูˆุซ

352
00:35:59,170 --> 00:36:05,370
ู…ุซู„ ุฐู„ูƒุŒ ุงุฎุชู„ุงู„ ุดุฏูŠุฏุŒ ุธุงู‡ุฑุฉ ู…ูˆุฌูˆุฏุฉ ููŠ ุงู„ู€ abortion

353
00:36:05,370 --> 00:36:11,450
ุงู„ู„ูŠ ุจูŠูƒู…ู„ ุงู„ุญู…ู„ ู…ุง ุจูŠูƒูˆู† ู…ุญุชู…ู„ ุฃู† ูŠูƒูˆู† ุนู†ุฏู‡ ู…ุซู„

354
00:36:11,450 --> 00:36:20,370
ุฐู„ูƒ. ุธุงู‡ุฑุฉ ู…ุชูˆู‚ุนุฉ ุชูƒูˆู† ู…ูˆุฌูˆุฏุฉ ููŠ ุงู„ูˆููŠุงุช ุฃูˆ ุงู„ู€

355
00:36:20,370 --> 00:36:26,010
spontaneous abortionsุŒ ูˆุงู„ุฅุฌู‡ุงุถุงุช ูƒุงู†

356
00:36:26,010 --> 00:36:34,190
ููŠู‡ 140 TurnerุŒ ุงู„ู„ูŠ ู‡ูˆ XOุŒ ุจุณ ู†ุตู‡ุง ูˆุงุญุฏุฉ ู…ู† ุงู„ู€ X

357
00:36:34,190 --> 00:36:40,650
ู…ุงููŠุด Y ุฃูˆ X ุซุงู†ูŠุฉ. ูˆุจุงู„ู†ุณุจุฉ ู„ู„ู€ Live Births ูƒุงู† ููŠู‡

358
00:36:40,650 --> 00:36:46,420
ุงุญุชู…ุงู„ูŠุฉ ูˆุงุญุฏุฉุŒ ูŠุนู†ูŠ ู…ู† 10,000 pregnanciesุŒ ุจุชูˆู‚ุน

359
00:36:46,420 --> 00:36:57,020
ุงู„ูˆุงุญุฏุŒ ูˆุงุญุฏ Turner ูŠูƒูˆู† ูŠุนู†ูŠ ู…ูˆุฌูˆุฏุŒ ูŠุนู†ูŠ. ูุทู„ุนุช

360
00:36:57,020 --> 00:37:02,540
ุงู„ู€ slideุŒ ุฏูƒุชูˆุฑุฉ

361
00:37:02,540 --> 00:37:05,580
ุงุณู…ู‡ุงุŒ ุฅุฐุง ุจุชุณุฃู„ุŒ ู…ู…ูƒู† ุชูˆุถูŠุญ ู„ุธุงู‡ุฑุฉ

362
00:37:05,580 --> 00:37:11,700
ุงู„ู€ IsochromosomeุŒ ุนุจุงุฑุฉ ุนู† ุฅูŠุด ู‡ูŠ ุจุชุทู„ุนุŸ ู…ู† ุฅูŠุดุŒ ู‚ุฏูŠู…

363
00:37:11,700 --> 00:37:14,840
ูˆู„ุง ููŠู‡ุง ููŠ ุงู„ู€ ุณู„ุงูŠุฏุŸ ู„ุฃุŒ ุฃุนุชู‚ุฏ ููŠ ุงู„ู€ ุณู„ุงูŠุฏ

364
00:37:14,840 --> 00:37:25,280
ุงู„ุณุงุจู‚ุŒ ูŠุนู†ูŠ "ุธุงู‡ุฑุฉ ุงู„ู€ Isochromosome". ุงู„ุฃุณุฆู„ุฉ

365
00:37:25,280 --> 00:37:30,360
ุฏุง ููŠู‡ุงุŒ ุฃูŠ ูˆุงุญุฏ ุนู†ุฏู‡ ุณุคุงู„ ูŠูˆู‚ู ูˆู‚ุชู‡ุงุŒ ุดุงูŠู ุนู„ูŠู‡ุŸ

366
00:37:30,360 --> 00:37:40,310
ูŠุนู†ูŠ ุงู„ู€ "ุงู†ูุฑุฌู„ ู„ูˆุจุฒ" ูˆุงู„ุฃุดูƒุงู„ ุงู„ุฃุฎุฑู‰ ู…ู† ุงู„ู€ ุฃุดูƒุงู„

367
00:37:40,310 --> 00:37:45,550
ุดูƒู„ ุงู„ูƒุฑูˆู…ูˆุฒูˆู… ูˆุงุฑุชุจุงุทุงุชู‡ู… ู…ุน ุจุนุถุŒ ุงู„ู„ูŠ ู‡ู… ุฃูƒุซุฑ ู…ู†

368
00:37:45,550 --> 00:37:52,050
ุดูƒู„ ูˆุฏูˆู„ุฉุŒ ูŠุนู†ูŠ ุฎู„ูŠู†ุง ุงู„ูŠูˆู… ู†ูˆู‚ูู‡ู… ุนู„ู‰ ุฅู†ู‡ู… ุฃู…ุซู„ุฉ

369
00:37:52,050 --> 00:37:59,310
ู„ู„ุงุฎุชู„ุงู„ุงุช ุงู„ู„ูŠ ู…ู…ูƒู† ุชุญุฏุซุŒ ุชูุงุตูŠู„ ู„ูŠุด ุญุฏุซุช ูˆูƒุฐุง

370
00:37:59,310 --> 00:38:05,690
ุงู„ูŠูˆู…ุŒ ูˆุงู„ุขู† ุฅุฐุง ู…ุง ุฅู„ู‡ุง ู†ุตูŠุจ ุจุนุฏูŠู† ู†ุฑุฌุญู‡ุง ููŠ ู…ุฑุถ

371
00:38:05,690 --> 00:38:11,380
ู…ุนูŠู†ุŒ ุฃูˆ ุฅุฐุง ู†ุชู†ุงู‚ุด ุนู† ุญุงู„ุฉ ู…ุนูŠู†ุฉ. ู…ุงุดูŠุŒ ู…ุง ุจุฏูŠุด

372
00:38:11,380 --> 00:38:17,140
ุฃุฏุฎู„ ููŠู‡ุง. ูŠุนู†ูŠ ุงู„ุขู† ู‡ุฐู‡ ุงู„ุฃุดูŠุงุก ุงู„ู„ูŠ ู‡ู†ุงุŒ ูŠุนู†ูŠ ุงู„ุธูˆุงู‡ุฑ

373
00:38:17,140 --> 00:38:25,140
ููŠ ุงุฎุชู„ุงู„ ุงู„ุชุฑูƒูŠุจ ุชุจุน ุงู„ู€ DNAุŒ ูƒู€ ChromosomeุŒ ูƒุดูƒู„

374
00:38:25,140 --> 00:38:31,320
ูƒู„ู‡. ุฅุฐุง ุงู„ุงุฎุชู„ุงู„ุŒ ุจุงู„ุฃุฎูŠุฑ ูƒู…ูŠุฉ ุงู„ู€ DNAุŒ Balance

375
00:38:31,320 --> 00:38:36,940
ู…ุชูˆุงุฒู†ุฉ ู…ุน ุงู„ุทุจูŠุนูŠุŒ ุจุงู„ุบุงู„ุจ ู†ูุณ ุงู„ุดุฎุต ู…ุง ุนู†ุฏู‡

376
00:38:36,940 --> 00:38:43,070
ู…ุดูƒู„ุฉุŒ ุจุณ ุจุชุณูˆูŠ ู…ุดุงูƒู„ ููŠ ุฐุฑูŠุชู‡ุŒ ู„ุฃู†ู‡ ุจุชู€ุฑุฌุน ุงู„ุฎู„ุงูŠุง

377
00:38:43,070 --> 00:38:46,670
ุจุฏู‡ ู„ุงุฒู… ุชุชู‚ุณู… ุจุงู„ู†ุตู ู…ุธุจูˆุทุŒ ูุจูŠุตูŠุฑ ููŠู‡ ุฌุฒุก ูˆููŠ

378
00:38:46,670 --> 00:38:52,430
ุฒูŠุงุฏุฉุŒ ูˆููŠ ุฌุฒุก ูˆููŠ ู†ู‚ุตุงู†. ูŠุนู†ูŠ ู‡ู†ุง ุงู„ู€ ู‡ุงูŠ

379
00:38:52,430 --> 00:38:58,310
ุฃู…ุซู„ุฉ ุนู„ู‰ ุงู„ุฃุดูŠุงุก ุงู„ู„ูŠ ู…ู…ูƒู† ุชุญุฏุซ. ุงู„ุฃู…ุซู„ุฉ

380
00:38:58,310 --> 00:39:03,230
ุนู„ู‰ ุงู„ู„ูŠ ุงู„ุขู† ุจู†ุญูƒูŠู‡ุงุŒ ูˆุตู„ุช ุฃู†ุง ู„ู„ู€ 45, XOุŒ ุงู„ู„ูŠ ู‡ูˆ

381
00:39:03,230 --> 00:39:12,120
ุงู„ู€ Turner ู‡ุฐุง. ูŠุนู†ูŠ ููŠู‡ ุฎู„ู„ุŒ ูˆููŠู‡ ู…ุฑุถุŒ ูˆููŠู‡ ุนุฏู… ู†ู…ูˆ ุทุจูŠุนูŠ

382
00:39:12,120 --> 00:39:20,920
ูˆู…ุดุงูƒู„ ูƒุซูŠุฑุฉุŒ ุจุณ ุจูŠุธู„ ุฃู†ู‡ ูŠุนู†ูŠ ุจุงู„ุฐุงุช ู„ุฃู† ุงู„ู€ Y

383
00:39:20,920 --> 00:39:25,840
-Chromosome ู…ุด ู…ู‡ู… ูƒุซูŠุฑุŒ ูƒุงู† ุฎูˆุงุต ู„ู„ุญูŠุงุฉ ูƒุซูŠุฑุฉ

384
00:39:25,840 --> 00:39:31,500
ูˆูƒุฐู„ูƒ ุงู„ู€ X ุงู„ุซุงู†ูŠ ุฃุตู„ุงู‹ ุจุชุฃุซุฑ ู†ุตู‡ู… ููŠ ู†ูุณ ุงู„ุฎู„ุงูŠุง

385
00:39:31,500 --> 00:39:34,980
ุฃูˆ ุงู„ู„ูŠ ู‡ูŠ ุงู„ู€ Ionization ุงู„ู„ูŠ ุฅุญู†ุง ู†ุญูƒูŠ ุนู†ู‡ุŒ ูู‡ูˆ

386
00:39:34,980 --> 00:39:39,020
ูŠุนุชุจุฑ ุดูŠุก ุฎููŠู. ูŠุนู†ูŠ ู‡ูˆ ุฃุดูŠุงุก ูˆุงุญุฏุฉุŒ ููŠ ู…ุฑุงุช ุจูŠูƒูˆู†

387
00:39:39,020 --> 00:39:47,020
ู…ู…ูƒู† ุฃู†ู‡ ูŠูƒูˆู† ุงู„ุฅู†ุณุงู† ูŠูƒู…ู„ุŒ ู„ุฃู†ู‡ ูŠุชู… ูˆู„ุงุฏุชู‡. "Trisomy

388
00:39:47,020 --> 00:39:54,120
16" ูˆ"Trisomy 18" ุจุชุญุฏุซ ุจู†ุณุจุฉ ุฃูƒุจุฑ ุจูƒุซูŠุฑ ุจุงู„ู€

389
00:39:54,120 --> 00:40:01,160
AbortionุŒ ู„ุฃู†ู‡ุง ุบูŠุฑ ูŠุนู†ูŠ ู…ุชูˆุงูู‚ุฉ ู…ุน ุงู„ุญูŠุงุฉุŒ ุจุณ ู…ู…ูƒู†

390
00:40:01,160 --> 00:40:05,660
ูŠุตู„ ุฅู†ู‡ ุทูู„ ูŠูˆู„ุฏ ููŠู‡ุงุŒ ุจุณ ู…ุง ุจูŠุทูˆู„ุด ุจุนุฏู‡ุง ูŠุนู†ูŠ

391
00:40:05,660 --> 00:40:10,840
"Trisomy 21" ุฑุงุญ ู†ุงุฎุฏ ุนู†ู‡ ุจุนุฏูŠู†ุŒ ุงู„ู„ูŠ ู‡ูˆ Down

392
00:40:10,840 --> 00:40:16,390
SyndromeุŒ ูˆููŠู‡ ู…ู…ูƒู† Other Types of TrisomyุŒ ููŠู‡ ุงู„ู€...

393
0

445
00:45:02,980 --> 00:45:07,740
ุงู„ู…ู†ุงุณุจ ุฎุงุถุน ู„ู„ุทุจูŠุนุฉุŒ ู…ุงุดูŠุŸ

446
00:45:07,740 --> 00:45:16,160
ูุงู„ุขู† ุงู„ูŠูˆู… ุฑุงุญ ู†ุชูƒู„ู… ุนู† ุงู„ู€Chromosomal Genomic Basis

447
00:45:16,160 --> 00:45:20,540
of Disorders of the Autosomes and Sex Chromosomes

448
00:45:20,540 --> 00:45:25,580
ูŠุนู†ูŠ ู†ุฑุฌุน ู…ุฑุฉ ุซุงู†ูŠุฉุŒ ู†ุฑุฌุน

449
00:45:25,580 --> 00:45:30,080
ู…ุฑุฉ ุซุงู†ูŠุฉ ู„ุฃุดูŠุงุก

450
00:45:30,080 --> 00:45:36,060
ุงู„ู‚ุฑูŠุจุฉ ุงู„ู„ูŠ ุฃุฎุฐู†ุงู‡ุง ู…ู†ู‡ุงุŒ ูŠุนู†ูŠ ุงู„ู„ูŠ ู‡ูˆ ู…ู† ุงู„ู€slide

451
00:45:36,060 --> 00:45:40,200
ุงู„ุฃุฎูŠุฑุŒ ุงู„ู€

452
00:45:42,020 --> 00:45:50,960
ุงู„ู†ู‚ุทุฉ ุงู„ุฃูˆู„ู‰ุŒ ู…ุงุดูŠุŒ ู„ูŠุดุŸ ูŠุนู†ูŠ ูˆูŠู† ุงู„ุฅุดูƒุงู„ูŠุฉ ุญุชู‰

453
00:45:50,960 --> 00:45:55,640
ุชุญุฏุซ ู…ุซู„ ู‡ุฐู‡ ุงู„ุฃุดูŠุงุกุŸ ุฃู† ูŠุตูŠุฑ ุนู†ุฏูŠ ุฎู„ู„ ููŠ ุนุฏุฏ

454
00:45:55,640 --> 00:46:04,940
ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุช ุฃูˆ ุฎู„ู„ ููŠ ูˆุฌูˆุฏู‡ุงุŒ ูˆูƒุฐุง ุฃู‡ู… ูˆุงุญุฏ ุฃู†ุง

455
00:46:04,940 --> 00:46:08,380
ุจุนุชุจุฑู‡ุŒ ูŠุนู†ูŠ ุนู„ู‰ ุงู„ุฃู‚ู„ ู‡ูŠูƒ ู„ู„ูˆุงุญุฏ ุญุชู‰ ูŠูู‡ู…ู‡ุงุŒ ุงู„ู„ูŠ

456
00:46:08,380 --> 00:46:12,670
ู‡ูŠ Abnormal Chromosomal SegregationุŒ ูŠุนู†ูŠ ุงู„ู€ Non

457
00:46:12,670 --> 00:46:21,170
-Disjunction. ูŠุนู†ูŠ ุงู„ููƒุฑุฉ ู‡ู†ุง ุฅู†ู‡ ุฃู†ุง ููŠ ุธุงู‡ุฑุฉ

458
00:46:21,170 --> 00:46:26,610
ุงู†ู‚ุณุงู… ุงู„ุฎู„ูŠุฉุŒ ุญูƒูŠู†ุง ุนู„ู‰ ุฅู†ู‡ ุจุงู„ู€ Metaphase ู„ุงุฒู…

459
00:46:26,610 --> 00:46:34,570
ุจุงู„ู†ุตูุŒ ููŠ ุงู„ู…ุณุชูˆู‰ ุงู„ู…ู†ุตู ู„ู„ุฎู„ูŠุฉุŒ ุชูŠุฌูŠ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุช

460
00:46:34,570 --> 00:46:42,230
ูƒู„ู‡ุง ุจุชุตู ุฌู†ุจ ุจุนุถุŒ ูƒู„ ุงุซู†ูŠู† ู…ู‚ุงุจู„ ุจุนุถุŒ ู…ุธุจูˆุทุงุชุŒ ูˆููŠู‡

461
00:46:42,230 --> 00:46:48,950
Central Zones ุนู„ู‰ ุงู„ุทุฑููŠู†ุŒ ูˆููŠู‡ ู‚ูŠูˆุท ุงู„ู€ Spindle

462
00:46:48,950 --> 00:46:57,370
Fibers ุงู„ู„ูŠ ู‡ูŠ ุฒูŠ ุงู„ุนุถู„ุงุช ุจุชุฌุฐุจ ุงู„ู‚ุทุนุชูŠู† ู‡ุฏูˆู„

463
00:46:57,370 --> 00:47:06,210
ู„ู„ุทุฑููŠู†ุŒ ู…ุงุดูŠุŸ ูŠุนู†ูŠ ู‡ูˆ ุงู„ู„ูŠ ุจุชูƒู„ู…ูˆุง ุนู†ู‡ุŒ ุฅุฐุง ู„ุณุจุจ

464
00:47:06,210 --> 00:47:14,440
ู…ุง ูƒุงู† ุนุฏู… ุงู†ูุตุงู„ ู†ุธูŠูุŒ ูƒุงู…ู„ุŒ ุณู„ูŠู… ุจูŠู† ุงู„ู€Two

465
00:47:14,440 --> 00:47:18,740
copiesุŒ ุฑุงุญ ูŠุตูŠุฑ ุนู†ุฏูŠ ู…ุง ูŠุณู…ูˆู†ู‡ ยซnon-disjunctionยป

466
00:47:18,740 --> 00:47:24,340
ูŠุนู†ูŠ ุฅู†ู‡ ู…ุง ุงู†ูุตู„ูˆุด ุนู† ุจุนุถ ุจุดูƒู„ ุณู„ูŠู…ุŒ ุฑุงุญ ูŠูƒูˆู† ุนู†ุฏูŠ

467
00:47:24,340 --> 00:47:29,360
ู†ุชูŠุฌุฉ ู‡ุฐุง ุงู„ุฃู…ุฑุŒ ูŠุง ุฅู…ุง ุงู„ุงุซู†ูŠู† ูƒู„ู‡ู… ูŠุฑูˆุญูˆุง ุนู„ู‰

468
00:47:29,360 --> 00:47:33,180
ุงู„ุฌู‡ุฉ ุงู„ูˆุงุญุฏุฉุŒ ูˆุจุงู„ุชุงู„ูŠ ุงู„ุฌู‡ุฉ ุงู„ุซุงู†ูŠุฉุŒ ูŠุนู†ูŠ ุงู„ู€Two

469
00:47:33,180 --> 00:47:36,810
copies ูƒู„ู‡ู… ูŠุฑูˆุญูˆุง ุงู„ุฌู‡ุฉ ุงู„ูˆุงุญุฏุฉุŒ ูˆุงู„ุฌู‡ุฉ ุงู„ุซุงู†ูŠุฉ ู…ุง

470
00:47:36,810 --> 00:47:40,570
ุฑุงุญ ูŠุฑูˆุญ ู„ู‡ุง ุดูŠุก ู…ู† ู‡ุฐุง ุงู„ู€ set ู…ู† ุงู„ู€

471
00:47:40,570 --> 00:47:47,270
ChromosomesุŒ ุฃูˆ ุฃู† ุฃุญูŠุงู†ุงู‹ ุฃู†ู‡ ูŠุนู†ูŠ ูˆุงุญุฏ ูˆู†ุตู ูŠุฑูˆุญ

472
00:47:47,270 --> 00:47:55,350
ู‡ุฐู‡ ุงู„ุฌู‡ุฉุŒ ูˆู†ุตู ูŠุฑูˆุญ ู‡ู†ุงูƒุŒ ู…ุงุดูŠุŸ ู†ุชูŠุฌุฉ ู‡ุฐุง ุงู„ุฃู…ุฑุŒ ูŠุนู†ูŠ

473
00:47:55,350 --> 00:48:04,170
ุฑุงุญ ูŠูƒูˆู† UnequalุŒ ูŠุนู†ูŠ ุชุบูŠุฑ ููŠ ุงู„ุนุฏุฏุŒ ู…ุงุดูŠุŒ

474
00:48:04,170 --> 00:48:07,830
ุฒูŠ ุงู„ู€Down SyndromeุŒ ุงู„ู€KlinefelterุŒ ูˆReversible

475
00:48:07,830 --> 00:48:14,210
DysenteryุŒ ูˆุฃุดูŠุงุกุŒ ูŠุนู†ูŠ ู…ู† ุงู„ุฃู…ุซู„ุฉ ุนู„ู‰ ุงู„ุฃู…ุฑุงุถุŒ ุฅู†ู‡

476
00:48:14,210 --> 00:48:20,090
ุชูƒูˆู† ุนู†ุฏูŠ ูŠุง ุฅู…ุง ุฒูŠุงุฏุฉ ูŠุง ุฅู…ุง ู†ู‚ุต. Recurrent

477
00:48:20,090 --> 00:48:24,290
chromosomal syndromesุŒ Dyadic chromosomal anomaliesุŒ

478
00:48:24,290 --> 00:48:27,790
Unbalanced familial anomaliesุŒ AbnormalitiesุŒ

479
00:48:27,790 --> 00:48:32,390
SyndromesุŒ Endowing Genetic Genomic Imprinting.

480
00:48:32,810 --> 00:48:43,070
ุงู„ุจุงู‚ูŠุฉ ู…ุง ุจุฏู‘ูŠุŒ ูŠุนู†ูŠ ูŠุนู†ูŠ ู…ุง ุจุฏู‘ูŠุŒ ู…ุด ู…ู‡ู… ูƒุซูŠุฑ ุฃุญูุธ

481
00:48:43,070 --> 00:48:48,630
ูˆุฃูู‡ู… ู„ูŠุด ุจุชุตูŠุฑ ูˆูƒูŠู ุจุชุตูŠุฑ ูˆูƒุฐุงุŒ ูŠุนู†ูŠ ุญูƒูŠู†ุง ู‚ุจู„

482
00:48:48,630 --> 00:48:54,030
ุดูˆูŠุฉ ุนู† ุฅู†ู‡ ุฅุฐุง ููŠ balanced translocation ู…ูˆุฌูˆุฏ ููŠ

483
00:48:54,030 --> 00:49:00,460
ุดุฎุต ู…ุนูŠู†ุŒ ู‡ุฐุง ุฑุญ ูŠุนู…ู„ ู…ุดูƒู„ุฉ ูˆูŠูƒูˆู† ููŠ ุงู„ู€ ุงู„ู€

484
00:49:00,460 --> 00:49:05,640
ProgenyุŒ ุงู„ุฐุฑูŠุฉ ุชุจุน ู‡ุฐุง ุงู„ุฅู†ุณุงู† ู†ูุณู‡ุŒ ู‡ูˆ ู…ู…ูƒู† ู…ุง

485
00:49:05,640 --> 00:49:09,800
ูŠุธู‡ุฑ ุนู„ูŠู‡ ุฃูŠ ู…ุฑุถุŒ ู…ุง ูŠูƒูˆู† ููŠู‡ ู…ุดูƒู„ุฉุŒ ุญุณุจ ุทุจูŠุนุฉ

486
00:49:09,800 --> 00:49:15,240
ุงู„ุฎู„ู„ุŒ ุทุจูŠุนุฉ ุงู„ุงู†ุชู‚ุงู„ุŒ ุทุจูŠุนุฉ ุงู„ุงุฑุชุจุงุทุŒ ุงู„ุจุนุถ ุจู†ุชุฌ

487
00:49:15,240 --> 00:49:21,560
ุนู†ู‡ุŒ ุฑุงุญ ู†ุญูƒูŠ ุนู„ู‰ ุฃู…ุฑุงุถ ูˆู…ุดุงูƒู„ ูˆุฃู†ูˆุงุน ู…ู† ุงู„ู…ุดุงูƒู„

488
00:49:21,560 --> 00:49:27,480
ุงู„ุชุงู„ูŠุฉุŒ ุจุณ ุจุธู„ุŒ ูŠุนู†ูŠ ุฃู†ุง ุฃุธู† ุงู„ุฃุณู‡ู„ุŒ ูˆููŠู†ุงุŒ ูŠุนู†ูŠ ููŠ

489
00:49:27,480 --> 00:49:32,810
ุฃู…ุฑุงุถ ูƒุซูŠุฑุฉ ู…ุดู‡ูˆุฑุฉุŒ ุฃูˆ ูˆุงุญุฏุฉ ุงู„ู…ูŠุฒุฉุŒ ุฅุฐุง ุดุงู ู…ุฑูŠุถ ู…ุซู„

490
00:49:32,810 --> 00:49:35,910
ู‡ุฐุง ุงู„ู†ูˆุนุŒ ุงู„ู„ูŠ ู‡ูŠ ุงู„ู€Non-disjunctionุŒ ุงู„ู„ูŠ ู‡ูŠ

491
00:49:35,910 --> 00:49:39,870
ุงู„ู€Abnormal Chromosomal SegregationุŒ ู‡ุฐู‡

492
00:49:39,870 --> 00:49:50,710
ุงู„ู€MechanismsุŒ ูˆุงู„ู„ูŠ ู†ุชูƒู„ู… ุนู†ู‡ ู‡ูŠ ุงู„ู†ูˆุนูŠุฉ ุงู„ุฃูƒุจุฑ ุฃูˆ

493
00:49:50,710 --> 00:49:54,190
ู†ูˆุนูŠุฉ  ู‚ุทุน ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุช ุงู„ุฃูƒุจุฑุŒ ุงู„ู„ูŠ ู‡ูŠ

494
00:49:54,190 --> 00:50:02,280
ุงู„ู€Chromosomal Anomalies. ุจุฐูƒุฑ ู…ุฑุฉ ุซุงู†ูŠุฉุŒ ุชุฐูƒุฑูˆุง ุฅู†ู‡

495
00:50:02,280 --> 00:50:06,920
ุฅุญู†ุง ููŠ ุชุนุงู…ู„ู†ุง ู…ุน ุงู„ุฃู…ุฑุงุถ ุงู„ูˆุฑุงุซูŠุฉุŒ ู„ุงุฒู… ู‡ูŠูƒ ุฃุญุทู‡ุง

496
00:50:06,920 --> 00:50:11,900
ุจูŠู† ุซู„ุงุซ ุฃู†ูˆุงุน: ูŠุง ุฅู…ุง ุดูŠุก ููŠ ุงู„ู€ Chromosome ูƒู„ู‡

497
00:50:11,900 --> 00:50:17,980
ูˆู‡ูŠ ุงู„ู„ูŠ ุฑุงุญ ู†ุชูƒู„ู… ุนู†ู‡ุงุŒ ูŠุง ุฅู…ุง MendelianุŒ ุงู„ู„ูŠ ู‡ูŠ

498
00:50:17,980 --> 00:50:22,140
Single NucleotideุŒ Single GeneุŒ Single ProteinุŒ

499
00:50:22,140 --> 00:50:30,400
ู…ุชุฎุตุตุฉ ุฅู„ู‰ ู‚ูˆุงุนุฏ ุงู„ูˆุตูˆู„ ูˆู…ุจุงุฏุฆุŒ ูˆููŠ ุงู„ู…ุฌู…ูˆุนุฉ ุงู„ุซุงู„ุซุฉ

500
00:50:30,400 --> 00:50:34,780
ุงู„ู„ูŠ ู‡ูŠ ุงู„ู„ูŠ ุจูŠุณู…ูˆู‡ุง PolygenicุŒ ุงู„ู„ูŠ ู‡ูŠ ุจุชูƒูˆู† ุฃูƒุซุฑ

501
00:50:34,780 --> 00:50:38,660
ู…ู† ุฌูŠู† ุจูŠุณุชุฎุฏู…ู‡ุงุŒ ูˆู‡ู†ุง ุงู„ู„ูŠ ู†ุญู† ู†ุชูƒู„ู… ุนู†ู‡

502
00:50:38,660 --> 00:50:44,820
Epigenetic ControlุŒ ุงู„ู€Genetic ImprintingุŒ ุงู„ู…ุดุบู„ุงุช

503
00:50:44,820 --> 00:50:50,140
ุงู„ู€DNA MethylationุŒ ุงู„ู€Histone MethylationุŒ ุงู„ู€Micro

504
00:50:50,140 --> 00:50:55,040
RNA Anomalies ุฃูˆ Changes. ููŠู‡ ู„ู‡ุง Mechanisms ูƒุซูŠุฑุฉ

505
00:50:55,040 --> 00:51:01,520
ุชุชุฏุฎู„ ุจุนุฏูŠู†ุŒ ุจุชุดุงุฑูƒุŒ ุฅู†ู‡ ุงู„ุฎู„ู„ ุฃูˆ ุงู„ุงุฎุชู„ุงู ูŠูƒูˆู† ููŠู‡

506
00:51:01,520 --> 00:51:07,260
ุนุฏุฏ ูƒุจูŠุฑ ู…ู† ุงู„ุฌูŠู†ุงุช ุจุทุฑูŠู‚ุฉ ู…ุฎุชู„ูุฉ ุชุชุญูƒู… ููŠ ูˆุธูŠูุฉ

507
00:51:07,260 --> 00:51:11,780
ุงู„ู€ChromosomeุŒ ุฃูˆ ูˆุธูŠูุฉ ุงู„ู€DNAุŒ ุฃูˆ ูˆุธูŠูุฉ ุงู„ุจุฑูˆุชูŠู†ุงุช.

508
00:51:11,780 --> 00:51:15,160
ูุญู†ุง ุงู„ูŠูˆู… ูˆุงู„ุขู† ุนู„ู‰ ุงู„ู€ChromosomeุŒ ุงู„ู€Autosomal

509
00:51:15,160 --> 00:51:18,860
ุงู„ู…ุฌู…ูˆุนุฉ

510
00:51:18,860 --> 00:51:25,030
ุงู„ุฃูˆู„ู‰ุŒ ุงู„ู„ูŠ ู‡ูˆ ูŠุนู†ูŠ ุฏุงุฆู…ุงู‹ ู…ุด ุบู„ุท ุงู„ูˆุงุญุฏ ูŠุชุฐูƒุฑ ุงู„ู„ูŠ

511
00:51:25,030 --> 00:51:33,330
ู‡ู… ุงู„ู€Downs ุงู„ู„ูŠ ู‡ู… ุงู„ู…ู‡ู… ุงู„ูˆุงุญุฏ ูŠุนุฑู ูุถูŠู‘ุฉ ุงู„ู„ูŠ ู‡ูŠ

512
00:51:33,330 --> 00:51:38,790
ุงู„ู€Common things are commonุŒ ุฃุดูŠุงุก ุดุงุฆุนุฉ ุดุงุฆุนุฉ

513
00:51:38,790 --> 00:51:43,150
ูˆุจุงู„ุชุงู„ูŠุŒ ูŠุนู†ูŠ ู‡ูˆ ุงู„ู„ูŠ ู„ุงุฒู… ูŠู‚ุฏุฑ ูŠู…ูŠุฒู‡ุง ุจุณุฑุนุฉ

514
00:51:43,150 --> 00:51:50,520
ูˆูŠู†ุชุจู‡ ุนู„ูŠู‡ุง ูˆูŠุชุนุงู…ู„ ู…ุนุงู‡ุง. ุงู„ู€ Trisomy 21ุŒ ูˆุงู„ุฃู†ูˆุงุน

515
00:51:50,520 --> 00:51:57,120
ุงู„ุซุงู†ูŠุฉ 18 ูˆ13ุŒ ุงู„ู„ูŠ ู‡ูŠ ู…ุซู„ู‹ุง Patau SyndromeุŒ Edwards Syndrome

516
00:51:57,120 --> 00:52:02,000
ุฃูˆ ุงู„ู€ Edwards SyndromeุŒ  ุฅู„ุฎ.  ุฅู„ุฎ.

517
00:52:02,000 --> 00:52:10,350
ุซุงู†ูŠุŒ ุซุงู†ูŠุŒ ู„ุฃ ุงู„ูˆุถุน ุฃุณูˆุฃ ุจูƒุซูŠุฑุŒ ู…ุงุดูŠุŒ ูˆูƒู„ู‡ู… ู…ุง ุจูŠุนูŠุดูˆุงุŒ

518
00:52:10,350 --> 00:52:14,750
ุจูŠู…ูˆุชูˆุง ุจุณุฑุนุฉุŒ ูˆู„ุงุฏุงุชุŒ ูŠุนู†ูŠ ุจุนุฏ ุงู„ูˆู„ุงุฏุฉ ุจุณุฑุนุฉุŒ ูˆููŠู‡

519
00:52:14,750 --> 00:52:17,770
severe mental retardationุŒ severe heart

520
00:52:17,770 --> 00:52:25,310
malformationุŒ ูƒุฐุงุŒ ุจุชู„ุงู‚ูŠ ููŠู‡ ู…ุดุงูƒู„ ูƒุจูŠุฑุฉ. ุงู„ู€ Down

521
00:52:25,310 --> 00:52:30,770
Syndrome ู…ุดู‡ูˆุฑ ูˆู…ุนุฑูˆูุŒ ู„ู…ุง ูƒู†ุช ุทุงู„ุจ ูƒู†ุง ู‡ูŠูƒ ู†ุชุญุฏู‰

522
00:52:30,770 --> 00:52:36,790
ุจุนุถ ุญุชู‰ ุงู„ูˆุงุญุฏ ูŠุฐูƒุฑู‡ุงุŒ ูƒู†ุง ู†ู‚ูˆู„ ููŠู‡ 30 characteristic

523
00:52:36,790 --> 00:52:42,690
ู…ูˆุฌูˆุฏุฉ ููŠ ุงู„ู€ Down Syndrome. ูู†ุชุจู‡ูˆุง ู‡ู†ุง: HypotoniaุŒ

524
00:52:42,690 --> 00:52:47,670
ูŠุนู†ูŠ ุงู„ุดุฏู‘ุฉ

525
00:52:47,670 --> 00:52:55,130
ุงู„ุนุถู„ุงุชุŒ ู‚ูˆุฉ ุงู„ุนุถู„ุงุชุŒ ููŠู‡ุง ุฑุฎุงูˆุฉ ูŠุนู†ูŠุŒ ูู€HypotoniaุŒ

526
00:52:55,130 --> 00:53:01,290
Short StatureุŒ ุงู„ุทูˆู„ ุงู„ู‚ุตูŠุฑุŒ Loose Skin on the

527
00:53:01,290 --> 00:53:07,610
napeุŒ ุงู„ู„ูŠ ู‡ูˆ ูŠุนู†ูŠ ุนู„ู‰ ุงู„ู€ .. ูŠุนู†ูŠ ููŠ ุฃุณูู„ ุงู„ุธู‡ุฑ ุฃูˆ

528
00:53:07,610 --> 00:53:12,410
ููŠ ุฃุณูู„ ุงู„ุฑู‚ุจุฉ. ุงู„ู€ Palmer creaseุŒ ุฅุญู†ุง ุงู„ุฃูŠุฏูŠู†

529
00:53:12,410 --> 00:53:16,130
ุงู„ูˆุงุญุฏุฉุŒ ุฏูŠ ูƒุฏู‡ ุจุชุทู„ุน ุนู„ูŠู‡ุงุŒ ููŠู‡ ุงู„ูู†ุชุงู† ุงู„ู„ูŠ ุชุดูˆูู‡

530
00:53:16,130 --> 00:53:20,350
ูˆุงุญุฏ ุนู†ุฏู‡ Down SyndromeุŒ ู…ุซู„ู‡ุง ูƒุฎุท ูˆุงุญุฏ. Palmer

531
00:53:20,350 --> 00:53:26,140
creaseุŒ ูˆclinodactylyุŒ ููŠู‡ ุฎู„ู„ ููŠ ุงู„ุฃุตุงุจุน. ุงู„ู€ Flat

532
00:53:26,140 --> 00:53:36,020
OccipitalุŒ ูŠุนู†ูŠ ุงู„ู…ุคุฎุฑุฉุŒ ุงู„ุฑุฃุณ ู…ุด ู…ุณุชุฏูŠุฑุฉุŒ ู‡ูŠูƒ ู…ุณุทุญุฉ

533
00:53:36,020 --> 00:53:40,960
ุงู„ู€ Epicanthic FoldsุŒ ุงู„ู„ูŠ ู‡ูŠ ูƒู…ุง ุจูŠู‚ูˆู„ูˆุง ู…ู†ุบูˆู„ูŠุฉ

534
00:53:40,960 --> 00:53:46,240
ูŠุนู†ูŠ ุดุจูŠู‡ุฉ ุจุนูŠูˆู† ุงู„ู…ุบูˆู„ ูˆุงู„ุตูŠู†ูŠูŠู†ุŒ ูˆGush fields ุงู„ู„ูŠ ู‡ูŠ

535
00:53:46,240 --> 00:53:52,550
ุญู‚ูŠู‚ุฉ ููŠ ุงู„ู€medial aspect of the eyeุŒ ุจุชู„ุงู‚ูŠ ููŠ ุงู„ู€โ€ฆ

536
00:53:52,550 --> 00:53:58,370
ููŠ ุงู„ู€โ€ฆ ูŠุนู†ูŠ fold ุจุทุฑูŠู‚ุฉ ู…ุนูŠู†ุฉุŒ ู‡ูŠ ุงู„ู„ูŠ ุจุชุนุทูŠ

537
00:53:58,370 --> 00:54:03,570
ุงู„ุนูŠูˆู† ุฒูŠ ุงู„ุตูŠู†ูŠูŠู†. ูŠุนู†ูŠ ุงู„ู€Brush field spotsุŒ ุญุงุทูŠู†

538
00:54:03,570 --> 00:54:08,150
ุตูˆุฑุฉ ู„ู‡ุง. ููŠ moderate to mildุŒ ุฃุญูŠุงู†ุงู‹ severe

539
00:54:08,150 --> 00:54:13,050
intellectual disabilityุŒ ุงู„ุชุฎู„ู ุงู„ุนู‚ู„ูŠ. congenital

540
00:54:13,050 --> 00:54:18,470
heart diseasesุŒ Duodenal atresiaุŒ ูŠุนู†ูŠ ุงุฎุชู„ุงู„ุงุช

541
00:54:18,470 --> 00:54:26,870
ุงู„ู‚ู„ุจุŒ ุงู„ุชุฑูƒูŠุจูŠุฉุŒ ุฃูˆ ุงู„ู…ุดุงูƒู„ ู„ู„ู‚ู„ุจุŒ ุชุณูƒูŠุฑ ุงู„ุฃุจู‡ุฑุŒ

542
00:54:26,870 --> 00:54:33,610
ุงุญุชู…ุงู„ูŠุฉ ุฃูƒุจุฑ ู„ู„ุณุฑุทุงู†ุงุชุŒ ุงุญุชู…ุงู„ูŠุฉ ุฃูƒุจุฑ ู„ู„ุชุฎู„ู

543
00:54:33,610 --> 00:54:41,850
ุงู„ุนู‚ู„ูŠ. ุงู„ุขู† ุจุงุณุชุฑุงุญุฉุŒ ูŠุนู†ูŠ ู…ูŠุฒุฉ ุงู„ู„ูŠ ุนู†ุฏู‡ู… Down

544
00:54:41,850 --> 00:54:48,810
SyndromeุŒ ุญู‚ูŠู‚ุฉู‹ุŒ ูŠุนู†ูŠ ุชุฐูƒุฑูˆุง ุฏุงุฆู…ุงู‹ ุนู†ู‡ู… ุฅู†ู‡ู… ุนู†ุฏู‡ู…

545
00:54:48,810 --> 00:54:55,230
pleasant personalityุŒ ูŠุนู†ูŠ ุดุฎุตูŠุชู‡ู… ู„ุทูŠูุฉุŒ ุญุจุงุจูŠู†ุŒ

546
00:54:55,230 --> 00:55:02,910
ุจู†ุญุจู‡ู…ุŒ ุญู„ูˆูŠู†ุŒ ุชุนุงู…ู„ู‡ู… ูŠุนู†ูŠ ุญู„ูˆ. ูŠุนู†ูŠุŒ ูˆุงู„ู€Life

547
00:55:02,910 --> 00:55:10,750
expectancy 55-60. ูŠุนู†ูŠ ู‡ุฐู‡ ุจุงุนุชุจุฑู‡ุง ุฃู†ุง ุฏุงุฆู…ุงู‹ ุฅู†ู‡ ุงู„ูˆุงุญุฏ

548
00:55:10,750 --> 00:55:17,290
ูŠุชุฐูƒุฑ ู…ุซู„ ู‡ุฐู‡ ุงู„ุญุงู„ุฉุŒ ู‡ูŠ ู…ูˆุฌูˆุฏุฉ ูˆู…ุชูˆุงุฌุฏุฉุŒ ุฃูˆ ุชู‚ุฑูŠุจุงู‹

549
00:55:17,290 --> 00:55:25,670
ูˆุงุญุฏุฉ ููŠ 850 ุฃู„ู ุญุงู„ุฉุŒ ูŠุนู†ูŠ ุชู‚ุฑูŠุจุงู‹ ุฃู‚ู„ ู…ู† ูˆุงุญุฏ ููŠ

550
00:55:25,670 --> 00:55:30,650
ุงู„ุฃู„ูุŒ ุฃูƒุซุฑ ุดูˆูŠุฉ ู…ู† ูˆุงุญุฏ ููŠ ุงู„ุฃู„ูุŒ ูˆุงุญุฏ ููŠ 850 ุจุชูˆู‚ุน

551
00:55:30,650 --> 00:55:36,070
ูŠูƒูˆู† ุนู†ุฏู‡ Down SyndromeุŒ ููŠุนู†ูŠ

552
00:55:36,070 --> 00:55:41,210
ู‡ุคู„ุงุก ุฌุฒุก ู…ู† ุงู„ู…ุฌุชู…ุนุŒ ุจุฏู‘ูŠ ุฅูŠุงูƒู… ูˆุงุญุฏ ูŠุญู† ุนู„ูŠู‡ู… ูˆ .. ุจุณ

553
00:55:41,210 --> 00:55:44,750
ุฃู†ุง ุจุธู†ุŒ ูŠุนู†ูŠ ู…ู† ุฃุฌู…ู„ ุงู„ุฃุดูŠุงุก ุฅู†ู‡ู… ู„ุทูŠููŠู†ุŒ ูŠุนู†ูŠ

554
00:55:44,750 --> 00:55:49,350
ุขู‡ุŒ ููŠ ุฃุณุฆู„ุฉุŸ

555
00:55:49,350 --> 00:55:57,530
ูุฅุฐุง ููŠ ุญุฏ ุนู†ุฏู‡ ุณุคุงู„ุŒ ูŠุณุฃู„. ุงู„ู…ู„ุงุญุธุฉ ุงู„ู…ู‡ู…ุฉ ุฃูˆ ู…ู‡ู…ุฉ

556
00:55:57,530 --> 00:56:04,330
ูƒุซูŠุฑุŒ ูุถู„ุงู‹ ุนู† ุฃู† ุงู„ู€ Down Syndrome ุฃุญูŠุงู†ุงู‹ ูƒุซูŠุฑุฉ

557
00:56:04,330 --> 00:56:05,910
ู…ุฑุชุจุทุฉ ุจุนู…ุฑ ุงู„ุฃู…

558
00:56:08,570 --> 00:56:14,390
ุฅุฐุง ุจุงู„ุฐุงุช ุงู„ุฃู… ุนู…ุฑู‡ุง ุฃูƒุซุฑ ู…ู† ุงู„ุฃุฑุจุนูŠู† ุณู†ุฉุŒ ู†ุณุจุฉ

559
00:56:14,390 --> 00:56:19,850
ุญุฏูˆุซ ุงู„ู€Down Syndrome ุชุฑุชูุน ุจู†ุณุจุฉ ุนุงู„ูŠุฉ ุฌุฏุงู‹

560
00:56:19,850 --> 00:56:24,810
ูŠุนู†ูŠ ู‡ู†ุง ุงู„ุทุฑูŠู‚ุชูŠู†

561
00:56:24,810 --> 00:56:30,350
ู„ู„ุฏุฑุงุณุฉุŒ ููŠ ุจุฒู„ ุงู„ุณู„ู‰ุŒ ุฃูˆ ุงู„ู„ูŠ ู‡ูˆ ุฃุฎุฐ ุณุงุฆู„

562
00:56:30,350 --> 00:56:35,030
ุญูˆุงู„ูŠ ู…ู† ุงู„ุฌู†ูŠู†ุŒ ุฃูˆ ุงู„ุงู†ุชุธุงุฑุŒ ูŠุนู†ูŠ ู‡ุฐู‡

563
00:56:35,030 --> 00:56:39,630
ุทุฑูŠู‚ุฉ ู…ู† ุงู„ุฏุฑุงุณุงุช. ู„ู„ุฃุณู ููŠ ุฏูˆู„ ุซุงู†ูŠุฉุŒ ุจูŠุนุชุจุฑูˆู†ู‡ ุฅู†ู‡

564
00:56:39,630 --> 00:56:47,510
ูุญุต ู„ู„ู€ DNAุŒ ุฃูˆ ู„ู‚ูŠ ู…ุฑุถ ู…ุนูŠู† ููŠ ุฐุงุช ุงู„ุญู…ู„ุŒ ุฅู†ู‡

565
00:56:47,510 --> 00:56:54,270
ุจูŠุนุฑุถูˆุง ุงู„ุฅุฌู‡ุงุถุŒ ุญุชู‰ ู…ุง ูŠุทู„ุน ุงู„ุทูู„ ุนู†ุฏู‡ ุฅุตุงุจุฉุŒ ุฃุณุงุณุงู‹

566
00:56:54,270 --> 00:56:57,730
ุจุงุนุชุจุงุฑู‡ ุฅู†ู‡ ููŠู‡ ุฌูˆุงู†ุจ ุฃุฎู„ุงู‚ูŠุฉ ููŠ ุงู„ุทุจ

567
00:56:57,730 --> 00:57:04,030
ูˆุฃุฎู„ุงู‚ูŠุฉ ููŠ ุงู„ุชุนุงู…ู„ ู…ุน ุงู„ุญูŠุงุฉ ูˆูƒุฐุงุŒ ู„ุฃู† ุฅุญู†ุง

568
00:57:04,030 --> 00:57:08,390
ุชู‚ุฑูŠุจุงู‹ุŒ ูŠุนู†ูŠ ููŠ ูƒู„ุงู… ุฅู†ู‡ ู‚ุจู„ ู†ูุฎ ุงู„ุฑูˆุญุŒ ูŠุนู†ูŠ ุฐุงูƒ

569
00:57:08,390 --> 00:57:13,390
ุงู„ุฑูˆุญุŒ ุงู„ู„ูŠ ู‡ูˆ ุชู‚ุฑูŠุจุงู‹ 120 ูŠูˆู…ุŒ ูŠุนู†ูŠ ููŠู‡ ุดูˆูŠุฉ ุฎู„ุงู

570
00:57:13,390 --> 00:57:17,650
ุจูŠู† ุงู„ูู‚ู‡ุงุก ูˆุงู„ุนู„ู…ุงุกุŒ ู…ู…ูƒู† ุงู„ูˆุงุญุฏ ูŠุนุฑุถ ุงู„ุฅุฌู‡ุงุถ

571
00:57:17,650 --> 00:57:24,390
ูˆู…ู…ูƒู†ุŒ ูŠุนู†ูŠ ุจู…ุง ุฅู†ู‡ ู„ุณู‡ ู…ุด ูƒุงุฆู†

572
00:57:24,390 --> 00:57:29,990
ุฃูˆ ู…ุด ุฅู†ุณุงู† ู…ูƒุชู…ู„ุŒ ูŠุนู†ูŠุŒ ูุงู„ููƒุฑุฉ ูŠุนู†ูŠุŒ ุจุณ ุงู„ู†ู‚ุทุฉ

573
00:57:29,990 --> 00:57:37,000
ุงู„ุฃุณุงุณูŠุฉุŒ ุฅู†ู‡ ุฅุฐุง ูƒุจุฑ ุนู…ุฑ ุงู„ุฃู…ุŒ ู†ุณุจุฉ ุงู„ู€ Down

574
00:57:37,000 --> 00:57:42,600
Syndrome ุจุชูƒุจุฑ ูƒุซูŠุฑุŒ ู…ุงุดูŠุŸ ูˆุฎุตูˆุตุงู‹ ููˆู‚ ุณู† ุงู„ุฃุฑุจุนูŠู†

575
00:57:42,600 --> 00:57:49,520
ูŠุนู†ูŠุŒ ู‡ูˆ  ุงู„ู†ุณุจุฉ ุจุชูƒูˆู† ูƒุจูŠุฑุฉุŒ  ูƒุจูŠุฑุฉ ุฌุฏุงู‹ุŒ ูู‡ุฐู‡ ู†ุงุญูŠุฉุŒ ู†ุงุญูŠุฉ

576
00:57:49,520 --> 00:57:55,780
ุซุงู†ูŠุฉุŒ ูŠุนู†ูŠ ู…ู† ุงู„ุฃุดูŠุงุก ุงู„ู„ูŠ ุงู„ูˆุงุญุฏ ุจุฏู‡ ูŠู†ุชุจู‡ ู„ู‡ุงุŒ ุฃู†

577
00:57:55,780 --> 00:58:00,920
ุฃุญูŠุงู†ุงู‹ ุงู„ู€ Trisomy 21 ู…ุง ุจูŠูƒูˆู†ุด ููŠ ูƒู„ ุงู„ุฎู„ุงูŠุงุŒ

578
00:58:00,920 --> 00:58:05,460
ุจุชูƒูˆู† ููŠ ู†ุณุจุฉ ู…ู† ุงู„ุฎู„ุงูŠุงุŒ ูˆุงู„ู…ู‚ุตูˆุฏ ุฅู†ู‡ ุงู„ู€ Non

579
00:58:05,460 --> 00:58:12,180
-disjunction ู‡ุฐุง ุงู„ู„ูŠ ุตุงุฑุŒ ูŠุนู†ูŠ ู…ุด ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ู€

580
00:58:12,180 --> 00:58:16,860
Egg ูˆุงู„ู€ SpermุŒ ุจุญูŠุซ ุฅู†ู‡ ูˆุงุญุฏ ู…ู†ู‡ู… ุจูŠูƒูˆู† ููŠู‡

581
00:58:16,860 --> 00:58:21,120
ุงู„ู…ุดูƒู„ุฉ. ู„ูˆ ุจุงู„ู€ Egg ูˆุงู„ู€ Sperm ุงู„ุฃุตู„ูŠูŠู†ุŒ ูƒู„

582
00:58:21,120 --> 00:58:24,720
ุงู„ุฎู„ุงูŠุง ุงู„ู„ูŠ ุฑุงุญ ุชุทู„ุน ุฑุงุญ ุชูƒูˆู† ููŠู‡ุง ู…ุดุงูƒู„ุŒ ุจุณ ู„ูˆ

583
00:58:24,720 --> 00:58:28,660
ุตุงุฑ Non-disjunction ุจุนุฏูŠู†ุŒ ูŠุนู†ูŠ ุจุนุฏ ู…ุง ุตุงุฑุช

584
00:58:28,660 --> 00:58:34,500
Fertilized Egg ูˆุงู†ู‚ุณู…ุช ู…ุซู„ุงู‹ ู…ุฑุชูŠู†ุŒ ุซู„ุงุซุŒ ูุตุงุฑ ุนู†ุฏูŠ

585
00:58:34,500 --> 00:58:39,140
ู…ุซู„ุงู‹ 16 ุฎู„ูŠุฉุŒ ูˆุงุญุฏุฉ ู…ู†ู‡ู… ู‡ูŠ ุงู„ู„ูŠ ุตุงุฑ ููŠู‡ุง Non

586
00:58:39,140 --> 00:58:44,000
-disjunctionุŒ ููŠ ุญุชุฉ ุฅู†ู‡ ุตุงุฑุช ููŠู‡ุง Trisomy 21ุŒ ููŠ

587
00:58:44,000 --> 00:58:48,460
ูˆุงุญุฏุฉ ู…ู†ู‡ู…. ููŠ ุญุชุฉ ุฅู†ู‡ ุจู†ุชุฌ ุนู† ู‡ุฐุง ุงู„ุฃู…ุฑ ุฅู†ู‡ ุฑุงุญ

588
00:58:48,460 --> 00:58:55,120
ูŠูƒูˆู† ุฅู†ู‡ ู†ุณุจุฉุŒ ูŠุนู†ูŠ ุฑุจุน ุงู„ุฎู„ุงูŠุงุŒ ุซู„ุซ ุงู„ุฎู„ุงูŠุงุŒ 60% ู…ู†

589
00:58:55,120 --> 00:58:59,960
ุงู„ุฎู„ุงูŠุง ุงู„ู„ูŠ ููŠู‡ุง ุงู„ุฎู„ู„ุŒ ูˆุงู„ุจู‚ูŠุฉ ุทุจูŠุนูŠุฉ. ููŠ ุชูุงูˆุชุŒ

590
00:58:59,960 --> 00:59:09,760
ูŠุนู†ูŠ ููŠ ุฏุฑุฌุงุช. ูู‡ูŠ ุทุจูŠุนุฉ ู…ู‡ู…ุฉ ู‡ู†ุงุŒ ุงู„ู€ Rough SpotsุŒ

591
00:59:09,760 --> 00:59:13,600
ุงู„ู€ Brush Field SpotsุŒ ู‡ู†ุง ุญุงุทูŠู† ูƒูŠู ุดูƒู„ ุงู„ุนูŠู†ุŒ ูŠุนู†ูŠ

592
00:59:13,600 --> 00:59:17,840
ุดูƒู„ ู…ุนูŠู†ุŒ ูˆู‡ูŠ ุงู„ู€ Epicanthic Fold ุงู„ู„ูŠ ู‡ูŠ ู„ู„ุฌูˆุง

593
00:59:17,840 --> 00:59:25,200
ูˆ Big TongueุŒ ูˆ Pleasant Personality. ูˆูŠุนู†ูŠ ู‡ุฐู‡ ุงู„ู„ูŠ

594
00:59:25,200 --> 00:59:31,370
ู‡ูˆ Down SyndromeุŒ ู…ู† ุฃุดูŠุงุก ุงู„ุฃู…ุฑุงุถ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ูŠุฉ ุงู„ู„ูŠ

595
00:59:31,370 --> 00:59:37,430
ู‡ูŠ ููŠ ุงู„ู…ุฌุชู…ุนุŒ ุงู„ู€

596
00:59:37,430 --> 00:59:48,290
ููŠู‡ ู‡ู†ุงูƒุŒ ูŠุนู†ูŠ ุฃุญูŠุงู†ุงู‹ ุญุชู‰ ู„ูˆ ุฃู†ุง ู…ุด ูƒุนุฏุฏุŒ ูƒู€ bandุŒ

597
00:59:48,290 --> 00:59:51,810
ูˆุนุฏุฏุŒ ู…ู…ูƒู† ุฃู„ุงู‚ูŠ ููŠ

598
00:59:56,860 --> 01:00:04,460
ูŠุนู†ูŠ ุฃุญูŠุงู†ุงู‹ ู…ุธู‡ุฑูŠุงู‹ ุจูƒูˆู† ุฅู†ุณุงู† ุดูƒู„ู‡ุŒ ู„ู…ุง ู†ุนู…ู„ู‡

599
01:00:04,460 --> 01:00:09,540
Carrier-typeุŒ ู„ู…ุง ุฃุฏู‚ู‚ุด ูƒุซูŠุฑุŒ ูˆู„ูƒู† ุจุงู„ุฃูˆู„ ุฅู†ู‡ ุจุณ ููŠ

600
01:00:09,540 --> 01:00:17,120
ู†ุณุฎุชูŠู† ู…ู† ุงู„ู€Chromosome 21. ูุจุธู† ุฅู† ุงู„ุชุดุฎูŠุต ุบู„ุทุŒ ุฃูˆ

601
01:00:17,120 --> 01:00:24,080
ุจู‚ูˆู„ ุฅู†ู‡ ููŠู‡ ู…ุดูƒู„ุฉุŒ ุจูƒูˆู† ุฅู†ู‡ ุงู„ู€Chromosome 21 ูƒู…ุง

602
01:00:24,080 --> 01:00:30,060
ู‡ูˆ ููŠ ุงู„ุตูˆุฑุฉ ู‡ุฐู‡ุŒ ุฑุงูƒุจ ู†ุณุฎุฉ ู…ู†ู‡ ุนู„ู‰ ูƒุฑูˆู…ูˆุฒูˆู… 14ุŒ ูƒุจูŠุฑ

603
01:00:30,060 --> 01:00:37,820
ูƒุฑูˆู…ูˆุฒูˆู… 14. ูˆุจุงู„ุชุงู„ูŠุŒ ุฃุญูŠุงู†ุงู‹ ุงู„ู€โ€ฆ ุงู„ู€โ€ฆ ูŠุนู†ูŠ ู‡ู†ุง

604
01:00:37,820 --> 01:00:41,940
ุฅุญู†ุง ุญุงุทูŠู† ู…ุซุงู„ ุฅู†ู‡ ุฃู†ุง ุงู„ู…ูุฑูˆุถ ุจุดูƒู„ ุทุจูŠุนูŠ ุฃูƒูˆู†

605
01:00:41,940 --> 01:00:48,480
ุนู†ุฏ ูƒุฑูˆู…ูˆุฒูˆู… 14 ูˆูƒุฑูˆู…ูˆุฒูˆู… 21 ู…ู†ูุตู„ุงุช ุจู‡ุฐุง ุงู„ุดูƒู„.

606
01:00:48,480 --> 01:00:55,160
ุฅุฐุง ููŠ ุนู†ุฏูŠ Balanced Translocation ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ุฅู†ู‡

607
01:00:55,460 --> 01:00:59,060
ุงู„ู€ Chromosome 21 ุงู„ู„ูŠ ู‡ูˆ ุฃู†ู‡ ุฃุตุบุฑ ูˆุงุญุฏุŒ ูˆู…ุทุฑุฏ ู‡ูŠูƒุŒ

608
01:00:59,060 --> 01:01:03,800
ูˆุตุบูŠุฑุŒ  ู„ุตู‚ ูƒู„ู‡ ุจุงู„ุบู„ุท ู…ุน Chromosome 14ุŒ ูˆุธู„ูˆุง

609
01:01:03,800 --> 01:01:10,120
ู…ูˆุฌูˆุฏูŠู† ู‡ู†ุงูƒ. ูุฅุฐุง ุฅู†ุณุงู† ุฎู„ุงูŠุงู‡ ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ุจุฑุถู‡ ู‡ุฐุง

610
01:01:10,120 --> 01:01:15,700
ู…ุง ุนู†ุฏู‡ ู…ุดูƒู„ุฉุŒ ุฅุฐุง ูƒุงู†ุช ุจุดูƒู„ ู…ุฎุชู„ู ุจู‡ุฐู‡ ุงู„ุฃุดูŠุงุก

611
01:01:15,700 --> 01:01:20,360
ุจุชูƒูˆู† ุงู„ุฃู…ูˆุฑ UnbalancedุŒ ูˆุจุชุฑูˆุญ ุชูƒูˆู† ููŠู‡ุง ู…ุดุงูƒู„

612
01:01:20,360 --> 01:01:27,290
ู…ุฎุชู„ูุฉ ูƒุจูŠุฑุฉ. ู‡ู†ุง ุฑุงุญ ูŠูƒูˆู† DownุŒ ู„ุฃู†ู‡ ููŠู‡ ุฒูŠุงุฏุฉ ุทุจุนุงู‹

613
01:01:27,290 --> 01:01:31,310
ู‡ุงูŠ one copyุŒ ูˆููŠู‡ copies ุซุงู†ูŠุฉ ุฒูŠู‡ุงุŒ ูุจู†ุชุฌ ุนู† ู‡ุฐุง

614
01:01:31,310 --> 01:01:35,210
ุงู„ุฃู…ุฑ ุงู„ุซุงู†ูŠุŒ ุงู„ู„ูŠ ู†ูุชุฑุถู‡ ุฑุงุญ ุชูƒูˆู† ุทุจูŠุนูŠุฉุŒ ุฑุงุญ ูŠูƒูˆู†

615
01:01:35,210 --> 01:01:40,570
ุฃู†ู‡ ุนู†ุฏูŠ ุซู„ุงุซุฉุŒ ุฃูˆ ู‡ู†ุง ููŠู‡ ูู‚ุฏ ุชุงู… ู„ู„ู€ 21ุŒ ู‡ู†ุง ููŠ

616
01:01:40,570 --> 01

667
01:07:01,820 --> 01:07:05,620
fourth pharyngeal pouches ุฃุชุฃู…ู„ ุฃู†ูƒู… ุฃุฎุฐุชู… ุงู„ู€

668
01:07:05,620 --> 01:07:10,820
embryology ู†ุชูŠุฌุฉ ู‡ุฐุง ุงู„ุฎู„ู„ ุจูŠุตูŠุฑ ุนู†ุฏูŠ ุซู„ุงุซ ู…ุธุงู‡ุฑ

669
01:07:10,820 --> 01:07:15,820
ุฑุฆูŠุณูŠุฉ ุงู„ู€ third ูˆุงู„ู€ fourth pharyngeal pouches

670
01:07:15,820 --> 01:07:23,000
ุจูŠูƒูˆู† ููŠู‡ู… ู„ุฃู†ู‡ู… ุฑุงุญ ูŠุนุทูŠ ุงู„ู€ Thymus ุฃูˆ ุงู„ุบุฏุฉ ุงู„ู€

671
01:07:23,000 --> 01:07:29,900
T ุงู„ู„ูŠ ู‡ูŠ ุชุจุนุช ุงู„ู…ู†ุงุนุฉ ุงู„ู„ูŠ ููŠ ุงู„ุตุฏุฑุŒ ุงู„ู…ู†ุทู‚ุฉ

672
01:07:29,900 --> 01:07:34,640
ุงู„ุฃู…ุงู…ูŠุฉ ู…ู† ุงู„ุตุฏุฑุŒ ูุจูŠุตูŠุฑ ุนู†ุฏูŠ Absent Thymus ูˆุงู„ู€

673
01:07:34,640 --> 01:07:38,020
Thymus ุถุฑูˆุฑูŠุฉ ู„ู€ Development ู„ู€ T-cells ููŠ

674
01:07:38,020 --> 01:07:44,280
ุงู„ู…ู†ุงุนุฉุŒ ู‡ูŠ ุจุชุชุนู„ู…ุŒ ู‡ูŠ ุชุชูƒูˆู†ุŒ ู‡ูŠ ุชุชู†ุดุท ููŠ ุงู„ู€ Thymus

675
01:07:44,280 --> 01:07:47,880
ูุจูŠุตูŠุฑ ุนู†ุฏูŠ Absence of T-cells ูˆุจุงู„ุชุงู„ูŠ ุนู†ุฏูŠ Immune

676
01:07:47,880 --> 01:07:52,100
DeficiencyุŒ ุจูŠุตูŠุฑ ุนู†ุฏู‡ Immune DeficiencyุŒ ุงู„ูˆุธูŠูุฉ

677
01:07:52,100 --> 01:07:55,480
ุงู„ุซุงู†ูŠุฉ ู„ู„ู€ third ูˆุงู„ู€ fourth pharyngeal pouches ุฅู†

678
01:07:55,480 --> 01:07:59,780
ู‡ูŠ ุจุชุดุชุฑูƒ ููŠ ุงู„ู€ root of the heartุŒ ููŠ ุงู„ู€ major

679
01:07:59,780 --> 01:08:04,100
blood vesselsุŒ ูุงู„ู€ major blood vesselsุŒ ุงู„ุฃูˆุฑุทุฉ

680
01:08:04,100 --> 01:08:08,460
ูˆุงู„ุจู„ู…ูˆู†ุฑูŠ ุขุฑุชูŠ ูˆุงู„ู€ truncus arteriosus ูˆุงู„ุฃุดูŠุงุก

681
01:08:08,460 --> 01:08:12,920
ู‡ุฐู‡ ุจุชุตูŠุฑ ููŠู‡ุง ุฎู„ู„ุŒ ูุจูŠุตูŠุฑ ุนู†ุฏูŠ congenital heart

682
01:08:12,920 --> 01:08:18,160
diseaseุŒ ุจูŠุตูŠุฑ ุนู†ุฏูŠ ู…ุฑุถ ู‚ู„ุจ ุฎู„ู‚ูŠุŒ ุนูŠุจ ุฎู„ู‚ูŠ ููŠ ุงู„ู‚ู„ุจ

683
01:08:18,920 --> 01:08:22,020
ุงู„ุดุบู„ ุงู„ุซุงู„ุซ ุงู„ู„ูŠ ุจุชูƒูˆู† ู†ุชูŠุฌุฉ ุงู„ู€ third ูˆุงู„ู€

684
01:08:22,020 --> 01:08:28,480
fourth pharyngeal pouches ุงู„ู„ูŠ ู‡ู… ุงู„ู€ ุงู„ู€ ุงู„ู€ ุงู„ู€

685
01:08:28,480 --> 01:08:33,540
Parathyroid glandsุŒ ูˆุงู„ู€ Parathyroid glands ุฃู‡ู…ูŠุชู‡ู…

686
01:08:33,540 --> 01:08:37,200
ุจุงู„ุชุญูƒู… ููŠ ุงู„ู€ metabolism ุชุจุน ุงู„ู€ calciumุŒ ูุจูŠุตูŠุฑ

687
01:08:37,200 --> 01:08:42,220
ุนู†ุฏูŠ ู…ุดูƒู„ุฉ hypocalcemia ูˆ tetanyุŒ ุจุตูŠุฑ ุงู„ุฌู†ูŠู† ุฃูˆ

688
01:08:42,220 --> 01:08:46,920
ุงู„ู€ ุฃูˆ ุงู„ุฌู†ูŠู† ูŠุนู†ูŠ ุงู„ู€ newborn ุจุตูŠุฑ ุนู†ุฏู‡ ุชุดู†ุฌุงุช

689
01:08:46,920 --> 01:08:51,020
ูˆ tetany ูˆูŠูƒูˆู† ู†ุชูŠุฌุฉ ุงู„ู€ Hypocalcemia ุจุณุจุจ

690
01:08:51,020 --> 01:08:57,780
ุงู„ู€ HypoparathyroidismุŒ ูุงู„ู€ Velo-cardio-facial syndromeุŒ ุฃูŠ ุงู„ุงุณู… ุงู„ุซุงู†ูŠ

691
01:08:57,780 --> 01:09:01,880
ู„ู„ู€ DiGeorge SyndromeุŒ ูŠูƒูˆู† ุนู†ุฏูŠ ู…ุดุงูƒู„ ููŠ ุงู„ู‚ู„ุจุŒ ู…ุดุงูƒู„

692
01:09:01,880 --> 01:09:06,680
ููŠ ุงู„ู€ Thymus ูˆููŠ ุงู„ู…ู†ุงุนุฉุŒ ูˆู…ุดุงูƒู„ ููŠ ุงู„ู€ Calcium ูˆููŠ

693
01:09:06,680 --> 01:09:11,160
ุงู„ู€ Metabolism ุชุจุน ุงู„ู€ Hypoparathyroidism

694
01:09:17,070 --> 01:09:22,250
ุงู„ู†ู‚ุทุฉ ุงู„ุฃุฎูŠุฑุฉ ููŠู‡ู… ุงู„ู„ูŠ ู‡ูŠ ู‚ุถูŠุฉ ุฅู†ู‡ ุฑุงุญ ูŠูƒูˆู†

695
01:09:22,250 --> 01:09:28,630
ุจูŠุณู…ูˆู‡ุง dysmorphic featuresุŒ ุงู„ุญุงุทูŠู† ู‡ู†ุง ุฃุธู† ุตูˆุฑ

696
01:09:28,630 --> 01:09:32,250
ุงู„ู„ูŠ

697
01:09:32,250 --> 01:09:38,210
ู‡ู… ุงู„ู€ Trisomy 21ุŒ ุฎู„ู‘ูŠู†ูŠ ุฃุดูˆูุŒ ู„ุฃ ู…ุด ุญุงุทูŠู†

698
01:09:38,210 --> 01:09:41,870
DiGeorge SyndromeุŒ ุจูŠุจูŠู†ูˆุงุŒ ุจูŠูƒูˆู† ุจูŠุณู…ูˆู‡ุง loss of

699
01:09:41,870 --> 01:09:50,300
earsุŒ ูŠุนู†ูŠ ุงู„ู€โ€ฆ ุงู„ู€โ€ฆ ู„ู…ุง ุงู„ูˆุงุญุฏ ูŠุดูˆู ุงู„ุฌู†ูŠู† ุงู„ุฃุตู„

700
01:09:50,300 --> 01:09:54,180
ููŠ ุงู„ุฅู†ุณุงู†ุŒ ุฅุฐุง ุงู„ูˆุงุญุฏ ุงู†ุชุจู‡ ุนู„ู‰ ุญุงู„ู‡ ุฅู†ู‡ ุงู„ุฃุฐู†ูŠู†

701
01:09:54,180 --> 01:09:57,820
ุจูŠูƒูˆู†ูˆุง ุนู„ู‰ ู…ุณุชูˆู‰ ุงู„ุนูŠู†ุŒ ูŠุนู†ูŠ ุฅุฐุง ุฃุฎุฏุช ุฎุท ุจูŠู†

702
01:09:57,820 --> 01:10:02,380
ุงู„ุขุฐู†ูŠู† ุชู‚ุฑูŠุจุงู‹ ู‡ู†ุงุŒ ุฅุฐุง ุงู„ุฃุฐู†ูŠู† ุงู„ูˆุงุญุฏ ุฃู†ุฒู„

703
01:10:02,380 --> 01:10:07,080
ู…ู† ู‡ุฐุง ุงู„ูˆุถุน ุจูŠุณู…ูˆู‡ุง loss of earุŒ ุจูŠูƒูˆู† increased

704
01:10:07,080 --> 01:10:11,340
philtrum ุงู„ู„ูŠ ู‡ูŠ ุงู„ู…ุณุงูุฉ ุจูŠู† ุงู„ุฃู†ู ูˆุงู„ุดูุฉ ุงู„ุนู„ูŠุง

705
01:10:11,880 --> 01:10:16,560
ุงู„ู„ูŠ ูƒูˆู†ู‡ุง ุดูƒู„ู‡ุง increaseุŒ ูุฅู†ู‡ุง ุดูƒู„ ู…ู…ูŠุฒุŒ ูŠุนู†ูŠ

706
01:10:16,560 --> 01:10:24,000
ูู‡ุฐุง ุฅูŠุด ุงุณู…ู‡ DiGeorge SyndromeุŒ ูุจู‚ูŠุฉ ุงู„ู€

707
01:10:24,000 --> 01:10:29,920
diseasesุŒ ุจุฏู‘ูŠุŒ ูŠุนู†ูŠ ุงู„ููƒุฑุฉ ููŠู‡ุง ุฃู…ุฑุงุถ ูƒุซูŠุฑุฉ ูˆู‡ูŠ

708
01:10:29,920 --> 01:10:36,100
list of examplesุŒ ูŠุนู†ูŠ ู‡ุฐูˆู„ุฉ ู†ุณุจุฉ ุฃูˆ ูŠุนู†ูŠ ุนุฏุฏ

709
01:10:36,100 --> 01:10:42,400
ู…ุญุฏูˆุฏ ู…ู† ุงู„ุฃู…ุซู„ุฉุŒ ูˆุฅู†ู‡ ููŠ ุนู†ุฏูŠ ุฃู…ุฑุงุถ ูƒุซูŠุฑุฉ ุฃุฎุฑู‰

710
01:10:42,400 --> 01:10:48,580
ุจูŠูƒูˆู†ุŒ ุฃู†ุง ุงู„ู…ุดูƒู„ุฉ ุนู†ุฏูŠ ู‡ูŠ segmental deletion ุฃูˆ

711
01:10:48,580 --> 01:10:53,560
duplicationุŒ ูŠุนู†ูŠ ุนุจุงุฑุฉ ุนู† ู‚ุทุนุฉ ู…ุด ุงู„ู€โ€ฆ

712
01:10:53,560 --> 01:11:00,120
ุงู„ู€ chromosome ูƒุงู…ู„ุŒ ู…ุงุดูŠุŸ ูู‡ุฐู‡ ุฃุดูŠุงุก ุจุชุญุฏุซ ูˆู…ูˆุฌูˆุฏุฉ

713
01:11:00,120 --> 01:11:08,040
ููŠ ุงู„ุทุจูŠุนุฉุŒ ู…ูˆุฌูˆุฏุฉ ููŠ ุงู„ุญูŠุงุฉุŒ ู…ูˆุฌูˆุฏุฉ ูˆู…ุคุซุฑุฉุŒ ูˆุงู„ูˆุงุญุฏ

714
01:11:08,040 --> 01:11:15,160
ูŠุทู„ุน ุนู†ุฏู‡ ุญุงู„ุฉ ุจุฏู‡ ูŠุญุณู† ุงู„ุชู†ู‚ูŠุจ ูˆุงู„ุจุญุซ ุนู† ู…ู†

715
01:11:15,160 --> 01:11:21,760
ุงู„ู…ุฑุงุฌุน ุงู„ุนู„ู…ูŠุฉ ุงู„ู…ุนุชู…ุฏุฉุŒ ุงู„ู€ Online Databases ุฒูŠ

716
01:11:21,760 --> 01:11:27,190
ู…ุง ุจู‚ูˆู„ู‡ุŒ ู‚ูˆุงุนุฏ ุงู„ุจูŠุงู†ุงุช ุนู„ู‰ ุงู„ู€ NetุŒ ุจุญูŠุซ ุฅู†ู‡ ูŠุฏุฎู„

717
01:11:27,190 --> 01:11:31,630
ูƒู„ ุงู„ู…ุนู„ูˆู…ุงุช ุงู„ู„ูŠ ุจุนุฑูู‡ุง ูƒู…ุธุงู‡ุฑ ูˆูŠุญุงูˆู„ ูŠู„ุงู‚ูŠ ู…ู†ู‡ุง

718
01:11:31,630 --> 01:11:39,170
ุดูˆ ุงู„ุชุดุฎูŠุต ุฃูˆ ูˆูŠู† ุงู„ุนู„ุฉ ุนุดุงู† ูŠุฎุชุงุฑ ุจุนุฏูŠู† ุงู„ู€ Test

719
01:11:39,170 --> 01:11:42,370
ุงู„ู…ู†ุงุณุจ ุญุชู‰ ูŠุซุจุช ุฅู† ู‡ุฐุง ุงู„ู…ูˆุถูˆุน ู…ูˆุฌูˆุฏ

720
01:11:42,370 --> 01:11:46,910
ูุงู„ู€ Rearrangement

721
01:11:46,910 --> 01:11:52,770
ู„ู‚ุถูŠุฉ ุงู„ู„ูŠ ูŠุตูŠุฑ Deletion ุฃูˆ DuplicationุŒ ุงุซู†ุงู†ู‡ู…

722
01:11:52,770 --> 01:11:58,920
ู„ู†ูุณ ุงู„ู€ MechanismุŒ ู„ู…ุง ู†ูƒูˆู† ุนู†ุฏูŠ ุณูˆุงุก ุฅุฐุง ูƒุงู…ู„ุŒ Non-

723
01:11:58,920 --> 01:12:02,920
distinctionุŒ ูŠุนู†ูŠ ุจุชูƒูˆู† ุงุซู†ุงู† ู…ุน ุจุนุถ ุจูŠุฑูˆุญูˆุง ู‡ูŠูƒ

724
01:12:02,920 --> 01:12:07,720
ุฃูˆ ุตูุฑ ุจูŠุฑูˆุญ ุงู„ุฌู‡ุฉ ุงู„ุซุงู†ูŠุฉุŒ ุจุชูƒูˆู† ูƒุงู…ู„ุฉ ุจุณ ุฃุญูŠุงู†ุงู‹

725
01:12:07,720 --> 01:12:13,160
ุจุชูƒูˆู† ุนู„ู‰ ู‚ุทุนุฉ ูˆุจุชูƒูˆู† ุฅู†ู‡ ุดูŠุก ุจูŠู†ุชู‚ู„ ู…ู† ู…ุญู„ ู„ู…ุญู„

726
01:12:13,160 --> 01:12:18,220
ุซุงู†ูŠุŒ ูุจู†ุชุฌ ุนู†ู‡ ุฅู†ู‡ ููŠ ู†ุณุฎุฉ ุฑุงุญ ุชูƒูˆู† Duplication

727
01:12:18,220 --> 01:12:23,440
ูˆููŠ ู†ุณุฎุฉ ุซุงู†ูŠุฉ ุฃูˆ ุฌู‡ุฉ ุซุงู†ูŠุฉ ุฑุงุญ ูŠูƒูˆู† ููŠู‡ Deletion

728
01:12:23,440 --> 01:12:32,240
ูู‡ูŠ ู„ู†ูุณ ุงู„ู€ MechanismุŒ ู‡ู†ุง ุจุฑุถู‡ ูŠุนู†ูŠ ู‡ุงูŠ ู‡ูˆู† ุงู„ู„ูŠ

729
01:12:32,240 --> 01:12:37,460
ุนู…ู„ู†ุง ุนู† ุทุฑูŠู‚ ุงู„ู€ KaryotypeุŒ ุนู„ู‰ BindingุŒ ุฏูˆุฑุช ุนู„ู‰

730
01:12:37,460 --> 01:12:45,080
ุดูŠุก ู…ุนูŠู†ุŒ ู…ู…ูƒู† ุฃู†ุง ู‡ู†ุง ุงู„ู€ FISH ูƒุฃุณู„ูˆุจ ุฃุฏูˆุฑ ุนู„ู‰

731
01:12:45,730 --> 01:12:53,610
ุจุทุฑูŠู‚ุฉ ู…ุนูŠู†ุฉ ุนู„ูŠู‡ู…ุŒ ูˆุจุนุฏูŠู† ููŠ ุนู†ุฏูŠ ุงู„ู„ูŠ ู‡ูˆ micro-

732
01:12:53,610 --> 01:12:59,850
arraysุŒ ุจุชูƒูˆู† ุฃู†ุง ู…ู…ูƒู† ุฃุฏูˆุฑ ุจุทุฑูŠู‚ุฉ ู…ุนูŠู†ุฉุŒ ูˆุจุนุฏูŠู†

733
01:12:59,850 --> 01:13:10,590
ุจุฑูˆุญ ุฃู‚ุฑุงู‡ุง ูˆูŠุนู†ูŠ ุจุชูƒูˆู† ุนู†ุฏูŠุŒ ุดูˆ ุงุณู…ู‡ุŸ ู…ุญุงุถุฑุฉุŒ ุฃู†ุงุŒ

734
01:13:10,590 --> 01:13:11,610
ู…ุญุงุถุฑุฉุŒ ู…ุญุงุถุฑุฉ

735
01:13:14,980 --> 01:13:23,480
ูุฃุณูุŒ ูŠุนู†ูŠ ู‡ุฐู‡ ุงู„ุขู„ูŠุงุช ุงู„ู…ุฎุชู„ูุฉ ู„ู…ุนุฑูุฉ ุงู„ู†ูˆุน

736
01:13:23,480 --> 01:13:30,080
ุงู„ุซุงู†ูŠ ู…ู† ุงู„ู€ Chromosome AnomaliesุŒ ูŠุนู†ูŠ ู‡ู†ุง

737
01:13:30,080 --> 01:13:36,060
ูƒู€ Chromosome ูƒุงู…ู„ุŒ ููŠู‡ ุนุฏุฏ ู…ุญุฏูˆุฏุŒ ู‚ุทุน ู…ู†

738
01:13:36,060 --> 01:13:41,140
ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุชุŒ ููŠู‡ ุจุฑุถู‡ ู†ุณุจุฉ ู…ูˆุฌูˆุฏุฉุŒ ู‡ู†ุงูƒ ุงู†ูู„ูˆู†ุฒุง ุนู„ูŠู‡ุง

739
01:13:41,140 --> 01:13:46,880
ุฏุฎู„ู†ุง ุนู„ู‰ ู‚ุตุฉ ุงู„ู€ DiGeorge Syndrome ูƒู…ุซุงู„ุŒ ู…ุง ุจุฏูŠุด ุบูŠุฑู‡ุŒ

740
01:13:46,880 --> 01:13:56,600
ุจุณ ุงู„ููƒุฑุฉ ุฅู†ู‡ ุจูŠูƒูˆู† ููŠ ุนู†ุฏูŠ ูŠุนู†ูŠ ู…ุธุงู‡ุฑ ู…ุชุนุฏุฏุฉ ูˆุฃู†ุง

741
01:13:56,600 --> 01:14:00,060
ุจุฅู…ูƒุงู†ูŠ ุฃุฏุฑุณู‡ุง ุจุทุฑู‚ ู…ุฎุชู„ูุฉ

742
01:14:03,080 --> 01:14:07,620
ููŠ ุญุงุฌุฉ ุงุณู…ู‡ุง "Brother Willy Engelman Syndromes"

743
01:14:07,620 --> 01:14:12,700
ูƒุงู†ูˆุง ุญุงุทูŠู† ุตูˆุฑู‡ู… ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ู…ุงุดูŠุŒ ุฑุฎุงูˆุฉ ููŠ

744
01:14:12,700 --> 01:14:20,420
ุงู„ุนุถู„ุงุชุŒ ุชุฎู„ู ุนู‚ู„ูŠุŒ ุฃู…ุฑุงุถุŒ ู…ุดุงูƒู„ ุซุงู†ูŠุฉุŒ ุฅุฐุง ุงู„ูˆุงุญุฏ

745
01:14:20,420 --> 01:14:27,520
ุจุฏู‘ู‡ ูŠุงุฎุฏ ุฎุท ุงู„ุทุจ ูƒู€ PediatricianุŒ ูƒู€ Geneticist ุฃูˆ

746
01:14:27,520 --> 01:14:30,340
ูƒุฐุงุŒ ุจุฏู‘ู‡ ูŠุตูŠุฑ ูŠุนุฑู ุนู†ู‡ู… ูˆูŠุชุนุงู…ู„ ู…ุนู‡ู…

747
01:14:34,340 --> 01:14:38,860
ุงู„ุขู† ุงู„ุฌุงู†ุจ ุงู„ุฃุฎูŠุฑ ู…ู† ุงู„ุฃู…ุฑุงุถ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ูŠุฉ ุงู„ู„ูŠ ู‡ูˆ

748
01:14:38,860 --> 01:14:43,220
ุงู„ู€ Sex ChromosomesุŒ ุงู„ู€ Sex Chromosomes ูŠุนู†ูŠ ู†ุงุญูŠุฉ

749
01:14:43,220 --> 01:14:52,960
ู…ู‡ู…ุฉ ูƒุชูŠุฑ ูˆูŠุนู†ูŠ ุจุฏู‡ุง ุชูƒูˆู† ู†ุงุจุนุฉ ู„ู„ูˆุงุญุฏ ู…ู† ูู‡ู… ุถุฑูˆุฑูŠ

750
01:14:52,960 --> 01:15:02,380
ู„ู„ู…ุจุงุฏุฆ ุชุจุนู‡ุง ุจุงู„ู†ุณุจุฉ ู„ู„ู€ Sex Development ูˆุชุทูˆุฑ

751
01:15:02,380 --> 01:15:12,050
ุงู„ุฅู†ุณุงู† ุงู„ุฌู†ุณูŠุŒ ุจู†ู„ุงู‚ูŠ ุฃู†ุง ุนู†ุฏูŠุŒ ุจุชูƒู„ู… ุนู† ุซู„ุงุซ

752
01:15:12,050 --> 01:15:20,710
ู…ุณุชูˆูŠุงุช ู…ู† ุงู„ู…ุธุงู‡ุฑุŒ ูˆุฃุญูŠุงู†ุงู‹ ุทุจุนุงู‹ ููŠ ุงู„ุบุงู„ุจ ุจุชูƒูˆู†

753
01:15:20,710 --> 01:15:27,830
ุจุทุฑู‚ ู…ุนูŠู†ุฉุŒ ุจุณ ู‡ู†ุงูƒ ุทุฑู‚ ู…ุชุนุฏุฏุฉ ู„ู„ุงุฎุชู„ุงู„ุงุชุŒ ูุงู„ุฃุตู„

754
01:15:27,830 --> 01:15:33,850
ุงู„ุฅู†ุณุงู† ุงู„ุฑุฌู„ุŒ ุงู„ุฐูƒุฑ ุจูŠูƒูˆู† ุนู†ุฏู‡ X Y chromosome

755
01:15:35,940 --> 01:15:44,340
ุงู„ุชุฑูƒูŠุจ ู„ู„ู€ genes ุฃูˆ ุงู„ุฃุนุถุงุก ุงู„ุชู†ุงุณู„ูŠุฉ ุชุจุนุชู‡ ุฅู†ู‡

756
01:15:44,340 --> 01:15:51,480
ุนู†ุฏู‡ ุฎุตูŠ ุฃูˆ TestesุŒ ู…ุงุดูŠุŒ ูˆุจุงู„ุฃุฎูŠุฑ ุจุชุนุทูŠ ู…ุธุงู‡ุฑ

757
01:15:51,480 --> 01:15:59,640
ุงู„ู„ูŠ ุจู†ุฑุฌุนู‡ุง ู„ู„ุฏูƒูˆุฑุฉุŒ ูŠุนู†ูŠ ุงู„ุตูˆุช ุฃุฌุดุŒ ุงู„ุดุนุฑ ููŠ

758
01:15:59,640 --> 01:16:04,500
ุงู„ู„ุญูŠุฉุŒ ูˆููŠ ู…ู†ุงุทู‚ ู…ุนูŠู†ุฉ ููŠ ุงู„ุฌุณู…ุŒ ูƒู…ูŠุฉ ุงู„ุนุถู„ุงุช ููŠ

759
01:16:04,500 --> 01:16:10,920
ุฌุณู…ู‡ ุฃูƒุจุฑุŒ ุงู„ู‡ุฑู…ูˆู†ุงุช ููŠ ุฌุณู…ู‡ ุชูƒูˆู† ู…ุฎุชู„ูุฉุŒ ู‡ุฐู‡

760
01:16:10,920 --> 01:16:15,040
ุงู„ู„ูŠ ุจูŠุณู…ูˆู‡ุง ู…ุธุงู‡ุฑ ุงู„ุฏูƒูˆุฑุฉ ุฃูˆ ุงู„ุฃู†ูˆุซุฉุŒ ุงู„ู€

761
01:16:15,040 --> 01:16:23,940
PhenotypeุŒ ุงู„ู€ Phenotype ู‡ุฐุง ู‡ูˆ ู†ุชูŠุฌุฉ ุฃูˆู„ ุดูŠุกุŒ ุฌุฒุก

762
01:16:23,940 --> 01:16:28,840
ู…ู†ู‡ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุชุŒ ูˆู…ุง ูŠู†ุชุฌ ุนู†ู‡ุง ู…ู† ุจุฑูˆุชูŠู†ุงุชุŒ ูˆู…ุง

763
01:16:28,840 --> 01:16:35,520
ูŠู†ุชุฌ ุนู†ู‡ุง ู…ู† ุชุฑุงูƒูŠุจุŒ ุซู… ุจุนุฏ ุฐู„ูƒ ุฌูˆุงู†ุจ ู‡ุฑู…ูˆู†ูŠุฉ

764
01:16:35,520 --> 01:16:41,980
ู†ุชูŠุฌุฉ ุงู„ู€ GonadsุŒ ูˆุจุนุฏ ุฐู„ูƒ ุงู„ุตุฑุงุญุฉ ุงู„ุฌูˆุงู†ุจ

765
01:16:41,980 --> 01:16:49,870
ุงู„ู…ุฌุชู…ุนูŠุฉุŒ ูŠุนู†ูŠ ุงู„ู€ role-playingุŒ ูŠุนู†ูŠ ุงู„ู…ุฌุชู…ุน ุนุงุฏุฉ

766
01:16:49,870 --> 01:16:56,750
ุงู„ุทูู„ ู…ู† ุตุบุฑู‡ ุฅุฐุง ูƒุงู† ุฐูƒุฑ ุจูŠุตูŠุฑูˆุง ูŠู‚ูˆู„ูˆุง ุฃู†ุช ุฒู„ู…ุฉ

767
01:16:56,750 --> 01:17:01,570
ูˆุงุด ุจุชุนูŠุท ุฒูŠ ุงู„ุจู†ุงุชุŸ ูˆู„ุง ุจูŠุตูŠุฑูˆุง ูŠุฑุจู‘ูˆู‡ ุนู„ู‰ ุฅู†ู‡ ูŠูƒูˆู†

768
01:17:01,570 --> 01:17:06,190
ุฎุดูŠู†ุŒ ุฅู†ู‡ ู…ุง ูŠุดูƒูŠุด ูˆุฅู†ู‡ ูƒุฏู‡ ูˆุฅู†ู‡ ูƒุฏู‡ุŒ ูƒุฏุง ุจุชู„ุงู‚ูŠ ู…ุธุงู‡ุฑ

769
01:17:06,190 --> 01:17:11,390
ุญุชู‰ ู…ู† ู†ุงุญูŠุฉ ุงู„ู…ุฌุชู…ุน ุจุชุชุฏุฎู„ ุดูˆูŠุฉุŒ ูŠุนู†ูŠ ู…ู†ุงุณุจ

770
01:17:11,900 --> 01:17:17,960
ู„ุฃู†ู‡ ู‡ุฐุง ุฑุฌู„ ุฃูˆ ู‡ูŠ ุฃู†ุซู‰ุŒ ูุจุงู„ู…ู‚ุงุจู„

771
01:17:17,960 --> 01:17:23,060
ุงู„ู€ FemalesุŒ ููŠ ุนู†ุฏู†ุง ุจูŠูƒูˆู† ุนู†ุฏู‡ู… XX chromosomes

772
01:17:23,060 --> 01:17:30,740
ุจุชูƒูˆู† ุนู†ุฏู†ุง ู…ุจุงูŠุถุŒ OvariesุŒ ูˆุจุนุฏูŠู† ุจูŠุตูŠุฑ ุงู„ุดูƒู„

773
01:17:30,740 --> 01:17:36,120
ุงู„ ู…ู…ูŠุฒ ู„ู„ู€ Phenotype ูƒู€ FemaleุŒ ุชุชุฏุฎู„ ููŠู‡ ุฃุดูŠุงุก

774
01:17:36,120 --> 01:17:40,060
ูƒุซูŠุฑุฉ ุงู„ุขู†

775
01:17:40,470 --> 01:17:46,230
ุงู„ู€ Y-ChromosomeุŒ ุญู‚ูŠู‚ุฉู‹ ููŠู‡ ุนุฏุฏ ู‚ู„ูŠู„ ู…ู† ุงู„ุฌูŠู†ุงุช

776
01:17:46,230 --> 01:17:51,890
ุญุงุทูŠู† ู‡ู†ุง ุชูุงุตูŠู„ุŒ ู…ู† ุฃุตุบุฑ ุงู„ู€ Chromosomes ูƒู…ุงู† ุฒูŠ

777
01:17:51,890 --> 01:17:57,070
ุงู„ู€ Chromosome 21 ู‚ุฑูŠุจ ู…ู†ู‡ ูŠุนู†ูŠ ููŠ ุงู„ุญุฌู…ุŒ ูˆุจูƒูˆู†

778
01:17:57,070 --> 01:18:06,910
ู…ุง ููŠู‡ุŒ ุฅูŠุด ุงุณู…ู‡ุŸ ู…ุง ูŠูƒูˆู†ุด ููŠู‡ ูŠุนู†ูŠ ูƒุจูŠุฑ ุนุฏุฏ ู…ู†

779
01:18:06,910 --> 01:18:12,010
ุงู„ู€ genes ุงู„ู„ูŠ ุจุชุฃุซุฑ ุนู„ู‰ ุฃุดูŠุงุก ู…ุญุฏุฏุฉุŒ ูŠุนู†ูŠุŒ

780
01:18:12,010 --> 01:18:16,450
ู…ุงุดูŠุŒ ููŠ ุฃุณุฆู„ุฉุŸ

781
01:18:16,450 --> 01:18:19,650
ุงู„ุณู„ุงู…

782
01:18:19,650 --> 01:18:23,250
ุนู„ูŠูƒู…ุŒ ููŠ ุฃุณุฆู„ุฉุŸ ุชู…ุงู… ู„ุญุฏ ุงู„ุขู† ูŠุง ุฏูƒุชูˆุฑุŒ ุชู…ุงู…ุŒ ู…ุง ููŠ

783
01:18:23,250 --> 01:18:30,010
ุณุคุงู„ ูŠุนู†ูŠุŒ ุทูŠุจุŒ ุงู„ูู‡ู… ู„ูƒูŠู ุชุทูˆุฑ ุงู„ุฐูƒูˆุฑ ูˆุงู„ุฅู†ุงุซ

784
01:18:30,590 --> 01:18:34,370
ูˆูƒูŠู ุฑุจู†ุง ุญุทู‘ ููŠู†ุง ู‡ูŠูƒ ุงู„ุฃุดูŠุงุกุŒ ูˆูƒูŠู ุฑุจู†ุง ุฎู„ู‚ู†ุง

785
01:18:34,370 --> 01:18:46,890
ุตุฑุงุญุฉ ููŠู‡ ูŠุนู†ูŠ ุฃูุถู„ ุชู‚ุฏูŠุฑ ูˆูŠุนู†ูŠ ูƒูŠู ุงู„ุฅู†ุณุงู† ุจูŠุชุฎู„ู‚

786
01:18:46,890 --> 01:18:51,970
ุญู‚ูŠู‚ุฉู‹ ูŠุนู†ูŠ ุนุฌูŠุจุฉ ู…ู† ุงู„ู„ู‡ ุณุจุญุงู†ู‡ ูˆุชุนุงู„ู‰ุŒ ู…ู† ุงู„ุฃุดูŠุงุก

787
01:18:51,970 --> 01:18:59,560
ุงู„ู„ูŠ ู„ุงุฒู… ุชูƒูˆู†ูˆุง ุชุชุฐูƒุฑูˆู‡ุง ุฃูˆู„ุงู‹ ุฅู†ู‡ ููŠ ุงู„ู€

788
01:18:59,560 --> 01:19:05,580
EmbryogenesisุŒ ูŠุนู†ูŠ ููŠ ู…ุฑุญู„ุฉ ุชูƒูˆูŠู† ุงู„ุฅู†ุณุงู†ุŒ ููŠ ู…ุฑุญู„ุฉ

789
01:19:05,580 --> 01:19:12,160
ุงู„ุฌู†ูŠู†ูŠุฉ ุงู„ู…ุจูƒุฑุฉุŒ ู†ุงุดุฆ ุงู„ุฅู†ุณุงู† ุจูŠูˆู„ุฏ ุจุงู„ุฃูˆู„ ุฃูˆ

790
01:19:12,160 --> 01:19:21,360
ุจูŠุชุฎู„ู‚ ุจุงู„ุฃูˆู„ ูˆุนู†ุฏู‡ ุชุฑุงูƒูŠุจ ูŠุนู†ูŠ ุฐูƒูˆุฑุฉ ูˆุฃู†ูˆุซุฉ ููŠ

791
01:19:21,360 --> 01:19:28,560
ู†ูุณ ุงู„ูˆู‚ุชุŒ ู†ุงุดุฆุŒ ุจู‚ุฑุง "mesonephric duct"ุŒ "mesonephric

792
01:19:28,560 --> 01:19:32,900
duct"ุŒ "mesonephric

793
01:19:32,900 --> 01:19:38,400
duct"ุŒ "mesonephric duct"ุŒ "mesonephric duct"ุŒ "mesonephric

794
01:19:38,400 --> 01:19:39,040
duct"ุŒ "mesonephric duct"ุŒ "mesonephric duct"ุŒ "mesonephric

795
01:19:39,040 --> 01:19:39,520
duct"ุŒ "mesonephric duct"ุŒ "mesonephric duct"ุŒ "mesonephric

796
01:19:39,520 --> 01:19:42,060
duct"ุŒ "mesonephric duct"ุŒ "mesonephric duct"ุŒ "mesonephric

797
01:19:42,060 --> 01:19:50,260
duct"ุŒ "mesonephric duct"ุŒ "mesonephric duct"ุŒ "mesonephric

798
01:19:50,260 --> 01:19:59,200
duct"ุŒ "meso ูŠุนู†ูŠ ุจูŠู‚ูˆู„ูˆุง ุงู„ู€ DefaultุŒ ูŠุนู†ูŠ ุงู„ุฅุนุฏุงุฏ

799
01:19:59,200 --> 01:20:06,700
ุงู„ุชู„ู‚ุงุฆูŠุŒ ุงู„ู€ Default Development ุจุชูƒูˆู† ุฅู†ู‡ ุงู„ุฅู†ุณุงู†

800
01:20:06,700 --> 01:20:16,420
ุจุชุญูˆู„ ุฅู„ู‰ ุฃู†ุซู‰ุŒ ุฅุฐุง ููŠู‡ ุงู„ู€ Y-ChromosomeุŒ ู…ุงุดูŠุŒ ุจุชุญูˆู„

801
01:20:16,420 --> 01:20:23,340
ู„ู„ุฏูุนุŒ ุฃู…ุง ุฅุฐุง ู…ุง ููŠุด Y-ChromosomeุŒ ูŠุนู†ูŠ ูˆุฌูˆุฏ ุงู„ู€ X ุฃูˆ

802
01:20:23,340 --> 01:20:28,620
ุฃูƒุซุฑ ู…ู† X ุฃูˆ ุนุฏุฏ ูƒุจูŠุฑ ู…ู† ุงู„ู€ X ู…ุง ุจูŠุฎู„ูŠ ุงู„ุฃู†ุซู‰

803
01:20:28,620 --> 01:20:35,100
ุชุชูƒูˆู†ุŒ ุนุฏู… ูˆุฌูˆุฏ ุงู„ู€ Y-Chromosome ู‡ูˆ ู…ุง ูŠุฏูุน ุงู„ู€

804
01:20:35,100 --> 01:20:41,560
Development ุฅู„ู‰ ู‚ุถูŠุฉ ุฃู† ูŠูƒูˆู† ุงู„ุดุฎุต ู‡ุฐุง ุฃู†ุซู‰ุŒ ููˆุฌูˆุฏ

805
01:20:41,560 --> 01:20:46,220
ุงู„ู€ Y-Chromosome ู‡ูˆ ุงู„ู„ูŠ ุจูŠุตู†ุน ุงู„ู€ TestesุŒ ุจูŠุญูˆู„

806
01:20:46,220 --> 01:20:52,050
ุฅู„ู‰ Testes ูˆุจูŠุบูŠุฑ ุดูƒู„ ุงู„ู‚ู†ูˆุงุช ุงู„ุจูˆู„ูŠุฉ ูˆุงู„ู‚ู†ูˆุงุช

807
01:20:52,050 --> 01:20:58,390
ุงู„ุชู†ุงุณู„ูŠุฉ ุจุญูŠุซ ุฅู†ู‡ ูŠุนุทูŠ ุดูƒู„ ุงู„ุฐูƒุฑ ููŠ ุงู„ู€ Internal

808
01:20:58,390 --> 01:21:02,490
ูˆุงู„ู€ External GenitaliaุŒ ุงู„ู„ูŠ ู‡ู… ุงู„ุฃุนุถุงุก ุงู„ุชู†ุงุณู„ูŠุฉ

809
01:21:02,490 --> 01:21:09,750
ุงู„ุฏุงุฎู„ูŠุฉ ูˆุงู„ุฎุงุฑุฌูŠุฉุŒ ุงู„ุจุฑุจุฎ ูˆุงู„ู‚ู†ูˆุงุช

810
01:21:09,750 --> 01:21:17,170
ุชุจุนุงุช ุงู„ู€ Sperms ูˆุงู„ุจุฑูˆุณุชุงุชุง

811
01:21:17,170 --> 01:21:25,120
ูˆุงู„ุฐูƒุฑ ูˆุงู„ุฃุดูŠุงุก ู‡ุฐู‡ุŒ ููŠ ู…ู‚ุงุจู„ ุนุฏู… ูˆุฌูˆุฏ ุงู„ู€ Y

812
01:21:25,120 --> 01:21:28,740
Chromosome ู‡ูˆ ู…ุง ูŠุฏูุน ุงู„ู€ Development ุฅู†ู‡ ุชุชุญูˆู„

813
01:21:28,740 --> 01:21:33,280
ุจุงุชุฌุงู‡ ุงู„ุฃู†ุซู‰ุŒ ูˆู‡ูŠ ุงู„ู„ูŠ ุจูŠุณู…ูˆู‡ุง ุงู„ู€ DefaultุŒ ูŠุนู†ูŠ

814
01:21:33,280 --> 01:21:37,300
ู‡ู†ุง ุฅุฐุง ู…ุง ููŠุด ุฃูŠ ู…ุคุซุฑ ุฎุงุฑุฌูŠ ุฑุงุญ ุชู…ุดูŠ ุจู‡ุฐุง ุงู„ุทุฑูŠู‚

815
01:21:37,300 --> 01:21:44,440
ูุจุชูƒูˆู† ุงู„ู…ุจูŠุถุŒ ูˆุจุนุฏูŠู† ู‚ู†ูˆุงุช Fallopian ูˆุจุนุฏูŠู† ุจู‚ูŠุฉ

816
01:21:44,440 --> 01:21:50,190
ุงู„ุฑุญู… ูˆู‚ุทุน ูˆุจุนุฏูŠู† ุงู„ู…ู‡ุจู„ ูˆุบูŠุฑู‡ุŒ ุงู„ู€ Female Internal

817
01:21:50,190 --> 01:21:56,510
ูˆ External GenitaliaุŒ ู…ุงุดูŠุŒ ูุงู„ุฅู†ุณุงู†

818
01:21:56,510 --> 01:22:06,270
ุงู„ุทุจูŠุนูŠ ูŠุนู†ูŠ ุนุงุฏุฉู‹ ุฅุฐุง ุฐูƒุฑ XYุŒ ุฅุฐุง ุฃู†ุซู‰ XXุŒ ูˆุงู„ุฃุตู„

819
01:22:06,270 --> 01:22:12,630
ูŠุนู†ูŠ ููŠ ุงู„ุชุญูƒู… ุฅู†ู‡ ุชุฑูˆุญ ุจุงุชุฌุงู‡ ุงู„ุฐูƒุฑุŒ ุงู„ุฐูƒูˆุฑุฉ ู‡ูŠ

820
01:22:12,630 --> 01:22:19,880
ูˆุฌูˆุฏ ุงู„ู€ YุŒ ูƒุซูŠุฑ ู…ู† ุงู„ู…ุธุงู‡ุฑ ู…ุฑุชุจุทุฉ ุจุนุฏ ู…ุง ุชุชูƒูˆู† ุงู„ู€

821
01:22:19,880 --> 01:22:24,280
Testes ูˆุชูƒูˆู† ู…ุตุฏุฑ ู„ู„ู‡ุฑู…ูˆู†ุงุชุŒ ุงู„ู€ Testosterone

822
01:22:24,280 --> 01:22:32,480
ูˆู‡ูˆ ุจูŠุคุฏูŠ ุฅู„ู‰ ุฅู† ุงู„ู…ุธุงู‡ุฑ ุชุชุงุจุน ูˆุชุชุบูŠุฑ ูˆุชูƒูˆู† ุจุงู„ุดูƒู„

823
01:22:32,480 --> 01:22:41,100
ุงู„ู„ูŠ ุนู†ุฏู†ุง ู…ูˆุฌูˆุฏุŒ ูู‡ูŠ ู†ูˆุงุญูŠ ู…ู‡ู…ุฉุŒ ุงู„ุขู† ููŠ ุธุงู‡ุฑุฉ

824
01:22:41,100 --> 01:22:47,490
ุญูƒูŠู†ุง ุนู†ู‡ุง ู…ู† ู‚ุจู„ุŒ ุทุจุนุงู‹ ุงู„ู€ X-Chromosome ุฃูƒุจุฑ ุจูƒุซูŠุฑ

825
01:22:47,490 --> 01:22:52,690
ูŠุนู†ูŠ ุงู„ู€ Chromosome ู…ุญุฑุฒุŒ ูƒุจูŠุฑ ูˆููŠ ุนู„ูŠู‡ ุฌูŠู†ุงุช

826
01:22:52,690 --> 01:22:57,790
ูƒุซูŠุฑุฉ ูˆู„ู‡ ุฏุฎู„ ููŠ ุฃุดูŠุงุก ูƒุซูŠุฑุฉุŒ ุทุจุนุงู‹ ุฃู‡ู… ู…ูŠุฒุฉ ููŠู‡

827
01:22:57,790 --> 01:23:02,670
ุฃูˆ ุฃู‡ู… ู…ุดูƒู„ุฉ ููŠู‡ ุฅู†ู‡ ู„ู…ุง ูŠูƒูˆู† ุนู†ุฏูŠ ู†ุณุฎุฉ

828
01:23:02,670 --> 01:23:08,730
ู…ุฑูŠุถุฉุŒ ุงู„ู€ Male ุฑุงุญ ูŠูƒูˆู† ูŠุฃูƒู„ ู‡ูˆุงุŒ ู„ุฃู†ู‡ ู„ูˆ ู†ุณุฎุฉ

829
01:23:08,730 --> 01:23:13,390
ูˆุงุญุฏุฉ ู…ุง ููŠุด ุนู†ุฏู‡ ู…ุฌุงู„ุŒ ุฅุฐุง ุจุงู„ุฐุงุช RecessiveุŒ ูˆู‡ูˆ ูŠุนู†ูŠ

830
01:23:13,390 --> 01:23:18,830
ุตูุฉ ู…ุชู†ุญูŠุฉ ุฑุงุญ ุชูƒูˆู† ุฅู†ู‡ุง ุฑุบู… ุฅู†ู‡ุง ู…ุชู†ุญูŠุฉ ุจุณ ุจุชุธู‡ุฑ

831
01:23:18,830 --> 01:23:25,990
ุจุงู„ุฐูƒูˆุฑุŒ ูุฏุงูŠู…ุงู‹ ูŠุนู†ูŠ ู‚ุถูŠุฉ ุงู„ู€ X-Chromosomes ูˆุฃู‡ู…ูŠุชู‡

832
01:23:25,990 --> 01:23:32,510
ูŠุนู†ูŠ ุดุบู„ ุณุจุญุงู† ุงู„ู„ู‡ ู…ู‡ู… ูƒุชูŠุฑุŒ ูู„ู…ู‘ุง

833
01:23:32,510 --> 01:23:39,330
ูŠูƒูˆู† ุงู„ุฃู†ุซู‰ ุฃูˆ ุญุชู‰ ู„ูˆ ุฐูƒุฑ ู…ุซู„ุงู‹ XXYุŒ ูˆุงู„ู€ XXY ุฑุงุญ

834
01:23:39,330 --> 01:23:47,430
ูŠูƒูˆู† ู…ุธู‡ุฑูŠุงู‹ ุฅูŠุดุŸ ุฐูƒุฑุŒ ู„ุฃู†ู‡ ุนู†ุฏ ุงู„ู€ YุŒ ู„ู…ุง ูŠูƒูˆู† XXY

835
01:23:47,430 --> 01:23:51,470
ุงู„ู€ two X ุฏูˆู„ ุจูŠูƒูˆู†ูˆุง ุงู„ุดุบุงู„ุงุชุŒ ุงุซู†ุงู† ููŠ ูƒู„

836
01:23:51,470 --> 01:24:02,490
ุงู„ุฎู„ุงูŠุงุŒ ู„ูˆ ุฃู†ุง ุจู‚ุฏุฑ ุฃุฏุฑุณ ุจุดูƒู„ ุนู…ูŠู‚ ุฃู†ูˆุงุน ุงู„ู€ DNA

837
01:24:02,490 --> 01:24:08,510
ุงู„ุดุบุงู„ ููŠ ูƒู„ ุฎู„ูŠุฉ ุจู„ุงู‚ูŠ ุฅู†ู‡ ููŠ ุญุงู„ุฉ ู„ู…ุง ูŠูƒูˆู† ุนู†ุฏูŠ

838
01:24:08,510 --> 01:24:14,650
ุฃูƒุซุฑ ู…ู† ู†ุณุฎุฉ ู…ู† ุงู„ู€ XุŒ ูˆุงุญุฏ ู…ู†ู‡ู… ุจุณ ุงู„ู„ูŠ ุดุบุงู„ุฉุŒ ูู‡ู†ุง

839
01:24:14

889
01:28:53,690 --> 01:29:02,090
ยซูƒุฑูˆู…ูˆุฒูˆู…ุงุชยป 49 ูˆุนู†ุฏู‡ุง X X X X X ู†ุงุดูŠุŒ ุชุญุฏุซุŒ ุบุงุฏุฑุฉ

890
01:29:02,090 --> 01:29:07,530
ุฌุฏุงู‹ ูˆุฅุฐุง ุจุฏูŠ ุฃุฏูˆุฑ ุนู„ูŠู‡ุง ูŠู…ูƒู† ุฃู„ุงู‚ูŠู‡ุง ูˆูƒุฐุง ุจุณ ูŠุนู†ูŠ

891
01:29:07,530 --> 01:29:12,210
ุงู„ููƒุฑุฉุŒ ุงู†ุชุจู‡ูˆุง ู‡ู†ุง ุฅู†ู‡ ุฏุงุฆู…ุงู‹ ุณูˆุงุก Male ูˆู„ุง

892
01:29:12,210 --> 01:29:16,870
Female ููŠู‡ one copy of the X chromosome which is

893
01:29:16,870 --> 01:29:24,930
activeุงู„ู„ูŠ ุจูŠุฎู„ู‘ูŠ ุงู„ุฅู†ุณุงู† ู…ุฐูƒุฑ ู‡ูˆ ุงู„ู€ Y ุจุบุถ ุงู„ู†ุธุฑ

894
01:29:24,930 --> 01:29:28,530
ูŠุนู†ูŠ ู‡ูˆ ุฃู†ุง ุญุงุทุท ู†ุณุฎุฉ ุฃูˆ ู†ุณุฎุชูŠู† ุฃูˆู„ ู…ุฑุฉ ุจุดูˆู ู‡ูŠูƒ

895
01:29:28,530 --> 01:29:37,710
ู‡ูŠ ุงู„ู€ XY-Chromosome ุฃูˆ XYY ู†ูุณ ุงู„ุดูŠุก ุฃูˆ XXY XXYY

896
01:29:37,710 --> 01:29:45,210
ูŠุนู†ูŠ ุงู„ุฏูˆุงู‡ุฑ ุงู„ู€ Non-disjunction ุฏูˆุงู‡ุฑ ุนุฏู…

897
01:29:45,210 --> 01:29:51,540
ุงู„ุงู†ูุตุงู„ ุจูŠู† ุงู„ู€ X ูˆุงู„ู€ Y-Chromosome ููŠ ุงู„ู€ Cell Cycle

898
01:29:51,540 --> 01:29:58,220
ุฃูƒุซุฑ ู…ู† ุจู‚ูŠุฉ ุงู„ูƒุฑูˆู…ูˆุฒูˆู…ุงุชุŒ ุงู„ุณุจุจ ุฅู†ู‡ ูˆุงุญุฏ ูƒุจูŠุฑ

899
01:29:58,220 --> 01:30:03,300
ูˆูˆุงุญุฏ ุตุบูŠุฑุŒ ุฅู†ูƒ ุชุฑูƒุจ ุงุซู†ูŠู† ูˆุงุฎุชู„ุงู ูƒุจูŠุฑ ููŠ ุงู„ุญุฌู…

900
01:30:03,300 --> 01:30:07,560
ุจุงู„ุจุนุถุŒ ุนุดุงู† ูŠู†ูุตู„ูˆุง ุจุดูƒู„ ุณู„ูŠู…ุŒ ู‡ุฐุง ู…ุง ุจูŠุญุฏุซ

901
01:30:07,560 --> 01:30:15,160
ูˆุจุงู„ุชุงู„ูŠ ุงุญุชู…ุงู„ูŠุงุช ุงู„ุฎู„ู„ ุฃูƒุจุฑุŒ ูู‡ุฐู‡ ุฃู…ุซู„ุฉ ุงุณู…ู‡ุง ุงู„ู€

902
01:30:15,160 --> 01:30:21,280
Bar Body ุงู„ู„ูŠ ู‡ูˆ ุงู„ู€ Inactive X-ChromosomeุŒ ูˆููŠ ุนู†ุฏู†ุง

903
01:30:21,280 --> 01:30:26,340
ุฃู…ุซู„ุฉ ุนู„ู‰ ุฃุญูŠุงู†ุงู‹ ุจุชูƒูˆู† ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ุฅู† ุดุงุก ุงู„ู„ู‡

904
01:30:26,340 --> 01:30:34,880
ุฅู†ู‡ุง ูˆุงุถุญุฉุŒ ุจุธู†ู‘ูŠ ุตุงุฑุช ุงู„ุณุงุนุฉ ุนุดุฑุฉุŒ ุจู†ูƒู…ู„ ุฅู† ุดุงุก

905
01:30:34,880 --> 01:30:40,120
ุงู„ู„ู‡ุŒ ูŠูˆู… ุจุนุฏ ุฅุฐู†ูƒุŒ ูŠุนู†ูŠ ู‚ุจู„ ู…ุง ุชู†ู‡ูŠุŒ ุงู„ู†ู‚ุทุฉ ุงู„ู„ูŠ

906
01:30:40,120 --> 01:30:43,520
ุณุฃู„ ุนู†ู‡ุง ูƒุฑูŠู… ุจุฎุตูˆุต ุงู„ู€Variation ููŠ ุงู„ู€Individual

907
01:30:43,520 --> 01:30:48,720
GenomesุŒ ูŠุนู†ูŠ ููŠ .. ู…ุด ุนุงุฑู ุฅูŠู‡ุŒ ุฃุธู†ู‘ ุฃู†ู‘ู‡ ู…ูˆุฌูˆุฏ ูŠุง

908
01:30:48,720 --> 01:30:55,680
ูƒุฑูŠู… ููŠ Chapter ุฑู‚ู… 4ุŒ ุตุญูŠุญุŸ ุฅุฐุง ุจุชุณู…ุนู†ูŠ ูŠุง ูƒุฑูŠู…

909
01:30:55,680 --> 01:31:01,160
Chapter ุฑู‚ู… 4ุŸ ุขู‡ุŒ ุตุญูŠุญุŒ ู…ูˆุฌูˆุฏ ููŠ Chapter ุฑู‚ู… 4

910
01:31:01,160 --> 01:31:05,860
ุขู‡ุŒ ุดูˆ ุจุฏู‘ูƒุŸ ุงู„ู†ู‚ุทุฉ ุงู„ู€ Variation ููŠ ุงู„ู€

911
01:31:05,860 --> 01:31:10,140
Individual Genomes ูŠุนู†ูŠ

912
01:31:10,140 --> 01:31:14,340
ุฅุญู†ุง ูƒู„ ุงู„ู…ุญุงุถุฑุฉ ุนู† ุฅู†ู‡ ููŠู‡ Variation ููŠ ุงู„ู€

913
01:31:14,340 --> 01:31:20,740
GenomeุŒ ุงู„ู€ Genome ุดูˆ ู‡ูˆุŸ ุงู„ู€ Genome ู‡ูˆ ู…ุฌู…ู„ ุงู„ู…ุงุฏุฉ

914
01:31:20,740 --> 01:31:26,100
ุงู„ูˆุฑุงุซูŠุฉ ูƒู„ู‡ุงุŒ ู„ู…ุง ู†ุชูƒู„ู… Genome ูŠุนู†ูŠ ูƒู„ ุงู„ู€ DNA ุชุจุน

915
01:31:26,100 --> 01:31:32,880
ุงู„ูƒุงุฆู† ุงู„ุฅู†ุณุงู†ูŠ ู‡ุฐุงุŒ ุฃูˆ ุงู„ุฅู†ุณุงู† ู‡ุฐุงุŒ ูููŠ ุนู†ุฏูŠ ูŠุนู†ูŠ

916
01:31:33,500 --> 01:31:39,160
ูุฃูŠ ู†ูˆุน ุงู„ู€ VariationุŸ ู‡ูˆ ู„ู‡ ุฃู†ูˆุงุน ูƒุซูŠุฑุฉุŒ ู„ู…ุง ูŠูƒูˆู†

917
01:31:39,160 --> 01:31:44,700
ูŠุดูˆู ุงู„ู„ูŠ ุจุญูƒูŠ ุนู†ู‡ ูŠูุฑุฌูŠู†ูŠุŒ ูŠุนู†ูŠ ุฏูƒุชูˆุฑ ูŠุนู†ูŠ ุฎู„ู‘ูŠู†ูŠ

918
01:31:44,700 --> 01:31:54,360
ุฃุดุงุฑูƒูƒ ุงู„ุตูˆุฑุฉ ุงู„ู„ูŠ ู‡ูˆ ุจุนุชู„ูŠ ุฅูŠุงู‡ุงุŒ ู†ุนู…ุŒ ุขู‡ ุทูŠุจุŒ

919
01:31:54,360 --> 01:32:01,840
ุฃู‡ุŒ ูุฑุฌูŠู†ูŠ ุงู„ุตูˆุฑุฉ

920
01:32:01,840 --> 01:32:07,200
ู…ูˆุฌูˆุฏุฉ ุงู„ุขู†ุŒ ู‡ูŠุŒ ู†ุนู…ุŒ ุฅุฐุง ุฃู†ุช ุดุงูŠูู‡ุงุŸ ุทูŠุจุŒ ู‡ุณุง ู‡ุงูŠ

921
01:32:07,200 --> 01:32:12,960
ู†ุญูƒูŠ ุนู† ุญุงู„ุฉ ู…ุญุฏุฏุฉุŒ ุงู„ู„ูŠ ู‡ูŠ ู†ูˆุน ู…ู† ุงู„ู€ Hemophilia

922
01:32:12,960 --> 01:32:20,020
ุงู„ู€ Hemophilia ุงู„ู„ูŠ ู‡ูˆ ุงู„ู€ Factor 8 ุชุจุน ุงู„ู€

923
01:32:20,020 --> 01:32:26,100
Clotting Factor ุชุจุน ุงู„ู„ูŠ ุจูŠุนู…ู„ ุชุฌู„ู‘ุท ุงู„ุฏู…ุŒ ู…ุงุดูŠุŒ ู…ูˆุฌูˆุฏุฉ

924
01:32:26,100 --> 01:32:31,500
ุนู„ู‰ ุงู„ู€ X-ChromosomeุŒ ู‡ุณุง ุงู„ู„ูŠ ุจูŠุตูŠุฑ ุฃุญูŠุงู†ุงู‹

925
01:32:31,770 --> 01:32:38,950
ู…ู…ูƒู† ู…ุซู„ู‹ุง ยซSnipยป ุฃูˆ ยซAs ifยป ยซDeletionยป ยซof One

926
01:32:38,950 --> 01:32:43,510
Nucleotideยป ุจูŠุนู…ู„ ยซFrame ShiftยปุŒ ุจูŠุฎุฑู‘ุจ ู„ูƒ ูƒู„

927
01:32:43,510 --> 01:32:49,830
ุงู„ุจุฑูˆุชูŠู† ูˆูŠุบู„ุท ุงู„ู€ ยซDNAยปุŒ ูŠุดุบู‘ู„ุŒ ู…ุงุดูŠุŒ ู‡ู†ุง ุธุงู‡ุฑุฉ

928
01:32:49,830 --> 01:32:56,970
ุซุงู†ูŠุฉุŒ ุงู„ุธุงู‡ุฑุฉ ู‡ุฐู‡ ุฅู†ู‡ ุฃู†ุง ููŠ ุนู†ุฏูŠ ู‚ุทุนุชูŠู† ู…ู…ูƒู†

929
01:32:56,970 --> 01:33:04,040
ู‡ุฐูˆู„ ูŠู„ุชุจูู‚ุงู† ุนู„ู‰ ุจุนุถุŒ ูู„ู…ุง ุงู„ู„ูŠ ู‡ูŠ ู…ุง ุจูŠู† ุงู„ู†ู‚ุทุฉ A

930
01:33:04,040 --> 01:33:12,000
ูˆุงู„ู†ู‚ุทุฉ BุŒ ูุงู„ุฃุตู„ ุงู„ู€ ยซุฃุตู„ยป ุงู„ู€ ยซูุงูƒุชูˆุฑ 8ยปุŒ ู…ุงุดูŠ ู„ู‡

931
01:33:12,000 --> 01:33:23,880
23 exons ูˆุจูŠู†ู‡ู… 22 intronsุŒ ูŠุนู†ูŠ ู„ู…ุง ุฃู†ุง ู‚ุงุนุฏ

932
01:33:23,880 --> 01:33:28,900
ุฃุตู†ุน ุงู„ุจุฑูˆุชูŠู† ู‡ุฐุงุŒ ุจุณูˆูŠ ุจุงู„ุฃูˆู„ transcription

933
01:33:31,800 --> 01:33:38,700
ู„ู„ุฏูŠุง ุงู„ู€ RNA ู„ูƒู„ ุงู„ู€ Introns ูˆุงู„ู€ ExonsุŒ ูˆุจุนุฏูŠู†

934
01:33:38,700 --> 01:33:43,140
ุจุตูŠุฑ ุฃู‚ุทุน ุงู„ู‚ุทุน ูˆุฃุฑูƒู‘ุจู‡ู… ุนู„ู‰ ุจุนุถุŒ ูŠุนุทูŠู†ูŠ ุงู„ุจุฑูˆุชูŠู†

935
01:33:43,140 --> 01:33:47,220
ุงู„ู„ูŠ ุฃู†ุง ุจุฏู‘ูŠ ุฅูŠุงู‡ุŒ ูˆุงุถุญุŸ

936
01:33:47,220 --> 01:33:52,580
ููŠ ุงู„ุญุงู„ุฉ ู‡ุฐู‡ุŒ ููŠ ุจุนุถ ุญุงู„ุงุช ุงู„ู‡ูŠู…ูˆููŠู„ูŠุง ุงู„ู„ูŠ ุจูŠุตูŠุฑ

937
01:33:52,580 --> 01:33:59,920
ุฃู†ู‘ ู‡ุฐูˆู„ ุงู„ู‚ุทุนุชูŠู† ู„ู…ุง ูŠูŠุฌูˆุง ุนู„ู‰ ุจุนุถุŒ ุงุญุชู…ุงู„ ุฃู†ู‘ู‡

938
01:33:59,920 --> 01:34:08,420
ู‡ูŠูƒุŒ ูŠุนู†ูŠ ูŠุดุจูƒุŒ ูู„ู…ุง ูŠุดุจูƒ ูˆุชูŠุฌูŠ ุจุนุฏูŠู† ุฃู†ุช ุชู‚ูˆู„ ุจุฏู‘ูŠ

939
01:34:08,420 --> 01:34:14,140
ุฃููƒู‡ ู…ุฑู‘ุฉ ุซุงู†ูŠุฉุŒ ุจูŠุตูŠุฑ ุงู„ู€ LoopุŒ ุจุฑูƒุจ ุงู„ุทุฑูŠู‚ุฉ ู…ุนูƒูˆุณุฉ

940
01:34:14,140 --> 01:34:22,740
ูุงู‡ู… ุนู„ูŠู‘ ูƒูŠู ุงู„ุตูˆุฑุฉ ุญุงุทู‘ูŠู†ู‡ุงุŒ ูุงู„ู„ูŠ ุจูŠุตูŠุฑ ุฃู†ู‘ ุงู„ู€ AB

941
01:34:22,740 --> 01:34:28,400
ู‡ุฐู‡ ุงู„ู‚ุทุนุฉ ุงู„ู„ูŠ ุณุจู‘ุจุช ุงู„ุฅุดูƒุงู„ูŠุฉุŒ ุฑุงุญ ุชุฎู„ูŠู‡ุง ุชุจุฏุฃ ุจุฏู„

942
01:34:28,400 --> 01:34:34,540
ู…ุง ู‡ูˆ ุฑู‚ู… 1ุŒ ุงุซู†ูŠู†ุŒ ุซู„ุงุซุฉุŒ ู„ุญุฏู‘ ุซู„ุงุซุฉ ูˆุนุดุฑูŠู†ุŒ ู…ุธุจูˆุท

943
01:34:34,540 --> 01:34:38,540
ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ุฑุงุญ ูŠุตูŠุฑ ุฅู†ู‘ู‡ ุจูŠุจุฏุฃ ุงุซู†ูŠู†ุŒ ูˆุนุดุฑูŠู†ุŒ ูˆูˆุงุญุฏ

944
01:34:38,540 --> 01:34:42,760
ูˆุนุดุฑูŠู† ูˆูƒุฐุง ูƒุฐุง ู„ูˆุงุญุฏุŒ ูˆุจุนุฏูŠู† ุจูŠุฌูŠ ุซู„ุงุซุฉ ูˆุนุดุฑูŠู† ู‡ู†ุง

945
01:34:42,760 --> 01:34:48,800
ูุฑุงุญ ูŠุฎุฑุจุท ู„ูƒ ุงู„ุฏู†ูŠุงุŒ ูˆูŠุตูŠุฑ ุงู„ุจุฑูˆุชูŠู† ู…ุง ู„ู‡ ูˆุธูŠูุฉ ูˆู…ุด

946
01:34:48,800 --> 01:34:55,300
ูƒูˆูŠุณุŒ ูุงู‡ู… ุนู„ูŠู‘ุŸ ูุจุนุถ ุญุงู„ุงุช ุงู„ู€ Hemophilia

947
01:34:55,300 --> 01:35:05,150
mutation ุจุชูƒูˆู† ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ูˆุงู„ุณุจุจ ุฃู†ู‘ู‡ ูŠุนู†ูŠ ู„ู…ุง ุชุฏุฑุณ

948
01:35:05,150 --> 01:35:13,810
ุจูŠู† ุงู„ุทุจูŠุนูŠ ูˆุจูŠู† ุงู„ู…ุตุงุจุŒ ุฃูˆู„ ุดูŠุก ูƒุญุฌู… ุงู„ู€ DNA ูƒุงู…ู„

949
01:35:13,810 --> 01:35:19,590
ุจุชู„ุงู‚ูŠ ู…ุชุณุงูˆูŠุŒ ู…ุง ููŠุด ู‡ู„ู‚ู„ุงู‚ุŒ ุจุณ ุชุฑุชูŠุจ ุงู„ู‚ุทุน ุชุจุนุงุช

950
01:35:19,590 --> 01:35:26,610
ุงู„ู€ Exon ุงู„ู„ูŠ ู‡ู… ุจุฏุฎู„ูˆุง ููŠ ุตู†ุงุนุฉ ุงู„ู€ Protein ูˆุงู„ู„ูŠ

951
01:35:26,610 --> 01:35:31,600
ุจูŠู†ู‡ู… ุงู„ู€ IntronsุŒ ู‡ู†ุง ุตุงุฑุช ุงู„ุฏู†ูŠุง ู…ู„ุบูˆุตุฉุŒ ู…ุฎุฑุจุทุฉุŒ

952
01:35:31,600 --> 01:35:36,520
ู„ุง ูŠู…ูƒู† ุงู„ุงุณุชูุงุฏุฉ ู…ู† ู‡ุฐู‡ ุงู„ุฃุดูŠุงุกุŒ ูˆู‡ุฐู‡ ุจุนุถ ุญุงู„ุงุช

953
01:35:36,520 --> 01:35:48,120
ุงู„ู€ Hemophilia ูˆุจุชูƒูˆู† ุจู‡ุฐุง ุงู„ุดูƒู„ุŒ ูˆุงุถุญุŸ ูˆุงุถุญ ูŠุง ูƒุฑูŠู…ุŸ

954
01:35:48,120 --> 01:35:55,360
ุชู…ุงู… ูŠุง ุฏูƒุชูˆุฑุŒ ูู‡ู…ุช ุนู„ูŠูƒุŒ ูŠุนู†ูŠ ู‡ุฐุง ู…ุซุงู„ุŒ ุฃุญูŠุงู†ุงู‹ ูŠุนู†ูŠ

955
01:35:55,360 --> 01:36:00,070
ุงู„ู„ูŠ ุจุฏู‘ูƒ ุชุนุฑูู‡ุง ุฃู†ู‘ู‡ ุงู„ุงุฎุชู„ุงู„ุงุช ุงู„ูˆุฑุงุซูŠุฉ ู…ุด ูƒู„ู‡ุง ุนู„ู‰

956
01:36:00,070 --> 01:36:05,750
ุทุจูŠุนุฉ ูˆุงุญุฏุฉ ูู‚ุทุŒ ูŠุนู†ูŠ ุฅู†ู‘ ุงู„ุจุฑูˆุชูŠู† ุฃูˆ ุงู„ุฌูŠู†

957
01:36:05,750 --> 01:36:12,210
ู…ุด ู…ูˆุฌูˆุฏ ุชู…ุงู…ุงู‹ุŒ ูŠุนู†ูŠ ุบูŠุฑ ู…ูˆุฌูˆุฏุŒ ู‡ุฐุง ยซdeletionยปุŒ ุฃูŠ

958
01:36:12,210 --> 01:36:18,910
ุทุจูŠุนุฉุŒ ุจุณ ู‡ู†ุง ุตุงุฑ ุงู„ู„ูŠ ู‡ูŠ ู‚ุถูŠุฉ ยซreverseยปุŒ ุงู„ุชุฑุชูŠุจ

959
01:36:18,910 --> 01:36:24,430
ุงู„ู‚ุทุนุŒ ููŠ ู†ูุณ ุงู„ุฌูŠู†ุŒ ุฅุญู†ุง ู‡ู†ุง ู…ุด ุฌูŠู†ุงุช ู…ุฎุชู„ูุฉุŒ

960
01:36:24,430 --> 01:36:32,740
ูู‡ุฐุง ู…ุซุงู„ ู„ู„ู€ Hemophilia ูˆู‡ูˆ ู…ุซุงู„ ุนู„ู‰ ุงู„ู€ Genetic

961
01:36:32,740 --> 01:36:37,980
Mutation ุจุชุฎุฑู‘ุจ ุงู„ุฌูŠู†ุŒ ุจุชุฎู„ู‘ูŠ ุงู„ุฅู†ุณุงู† ุนู†ุฏู‡ ู…ุฑุถ ุฃูˆ

962
01:36:37,980 --> 01:36:43,060
Hemophilia ูˆุจูŠุจุทู„ ูŠู‚ุฏุฑ ูŠุตู†ุน ุงู„ุจุฑูˆุชูŠู† ู‡ุฐุงุŒ ูˆุงู„ุณุจุจ

963
01:36:43,060 --> 01:36:49,560
ุฃู†ู‘ู‡ ุงุฎุชู„ูุฉ ุทุฑูŠู‚ุฉ ุตู†ุงุนุฉ ุงู„ุจุฑูˆุชูŠู†ุŒ ุจุนุฏูŠู† ูƒู€

964
01:36:49,560 --> 01:36:56,100
Transcription ูˆ TranslationุŒ ุจุทู„ุช ุชู‚ุฏุฑ ุชุตู†ุนู‡ุŒ ุชู…ุงู…ุŸ

965
01:36:58,550 --> 01:37:01,650
ุชู…ุงู…ุŒ ุฅู† ุดุงุก ุงู„ู„ู‡ุŒ ู‡ูˆ ูŠุนู†ูŠ ูˆุงุถุญุฉ ุงู„ุตูˆุฑุฉ ุฃุนุชู‚ุฏุŒ ุนู†ุฏู‡

966
01:37:01,650 --> 01:37:04,890
ููŠ ุจุณ ุณุคุงู„ ู…ู† ุจุณู…ุฉุŒ ุจุชุณุฃู„ ูŠุนู†ูŠ ุงู„ู€Balance

967
01:37:04,890 --> 01:37:08,850
TranslocationุŒ ูŠุนู†ูŠ ู‚ุตุฏูƒ ุงู„ู€โ€ฆ ู‚ุตุฏูƒ ุนู„ู‰ ู†ูุณ ุงู„ู€slide

968
01:37:08,850 --> 01:37:15,130
ุดูƒู„ู‡ุŸ ู‡ูŠุŒ ู‡ู†ุง ุจุฏู‘ูƒ ุชุนุชุจุฑู‡ุง ุงู„ู€โ€ฆ ู‡ู†ุง ู…ุด

969
01:37:15,130 --> 01:37:18,570
ุงู„ู€TranslocationุŒ ูŠุนู†ูŠ ุงู„ู€TranslocationุŒ ุฅุญู†ุง ุนู… ู†ุญูƒูŠ

970
01:37:18,570 --> 01:37:24,850
ุนู† BandุŒ ู‡ู†ุง ุฅุญู†ุง ุจู…ุณุชูˆู‰ ุนู„ู‰ one geneุŒ ูŠุนู†ูŠ ุฅุญู†ุง

971
01:37:24,850 --> 01:37:32,840
ู‡ู†ุง ููŠ ู…ุณุชูˆู‰ ุฃู‚ู„ุŒ ู„ู…ุง ู†ุญูƒูŠ ุนู† Band ูˆู‚ุทุน ู…ู† ุงู„ู€

972
01:37:32,840 --> 01:37:41,500
Chromosomes ูˆู‚ุทุน ุฃูƒุจุฑุŒ ู…ุงุดูŠุŒ ุฅุฐุง ุฒูŠ ู…ุง ุญุทู‘ูŠู†ุง ุงู„ู€ ..

973
01:37:41,500 --> 01:37:49,620
ุฅุฐุง ุฎู„ู‘ูŠู†ูŠ ุฃูˆุฑุฌูŠฺฏู… ุตูˆุฑุฉ ุญุทู‘ูŠู†ุง ุนู† Down SyndromeุŒ Down

974
01:37:49,620 --> 01:37:56,220
SyndromeุŒ Trisomy 21ุŒ ูˆุงุถุญุŒ ุนุงุฏุฉ ู…ู† ู‡ู†ุงูƒ ุจุณ ููŠู‡ ู†ุณุจุฉ

975
01:37:56,220 --> 01:38:04,520
ู„ู…ุง ู‚ุงุนุฏ ุฃุฏุฑุณ ุงู„ู€ ุงู„ู€ ุงู„ู€ ุงู„ู€ 21 Trisomy ุจู„ุงู‚ูŠ

976
01:38:04,520 --> 01:38:10,900
ู…ุง ููŠุด 21 ExcessุŒ ูŠุนู†ูŠ ููŠู‡ Two copies ูˆุจุณุŒ ูุจูŠูƒูˆู† ุฅู†ู‘ู‡

977
01:38:10,900 --> 01:38:18,780
ููŠู‡ ู†ุณุฎุฉ ุซุงู„ุซุฉ ุฑุงูƒุจุฉ ุนู„ู‰ Chromosome 14ุŒ ูู‡ุณุง ุฅุฐุง

978
01:38:18,780 --> 01:38:24,770
ุฅู†ุณุงู† ุนู†ุฏู‡ ู†ุณุฎุฉ ูˆุงุญุฏุฉ ูู‚ุท ู…ู† ุงู„ู€ Chromosome

979
01:38:24,770 --> 01:38:29,870
21 ูˆุงู„ุซุงู†ูŠุฉ ุฑุงูƒุจุฉ ุนู„ู‰ Chromosome 14ุŒ ูุจุงู„ุฃุฎูŠุฑ ุฃู†ู‘ู‡

980
01:38:29,870 --> 01:38:33,230
ุตุงุฑ Two copies of Chromosome 21 ูˆTwo copies of

981
01:38:33,230 --> 01:38:39,230
Chromosome 14ุŒ ูˆู‡ุฐุง BalanceุŒ ู‡ุฐุง ู‡ูˆ ู†ูุณู‡ ุฅู†ุณุงู† ุทุจูŠุนูŠ

982
01:38:39,230 --> 01:38:44,350
ู„ู…ุง ูŠูƒูˆู† ุฅู†ุณุงู† ูŠูƒูˆู† BalancedุŒ ูŠุนู†ูŠ ูƒู…ูŠุฉ ุงู„ู€ DNA ุงู„ู„ูŠ

983
01:38:44,350 --> 01:38:50,010
ููŠ ุฌุณู…ู‡ ุทุจูŠุนูŠุฉุŒ ู…ุดุงุจู‡ุฉ ู„ูƒู…ูŠุฉ ุงู„ู…ุชูˆู‚ุนุฉ ุงู„ุทุจูŠุนูŠุฉ

984
01:38:50,380 --> 01:38:56,580
ูˆุจุงู„ุฃุฎูŠุฑ ู…ุธู‡ุฑูŠุงู‹ ู„ุง ูŠุจุฏูˆ ุนู„ูŠู‡ ู…ุฑุถุŒ ูˆู„ูƒู†ุŒ ุชุจูŠู‘ู† ุงู„ู€

985
01:38:56,580 --> 01:39:03,220
DNA ู„ู…ุง ุจุฏู‘ูŠ ูŠุฌูŠ ู‡ูˆ ูŠุฎู„ูุŒ ูŠุตูŠุฑ ุชู†ู‚ุณู… ุฎู„ุงูŠุงู‡ ูˆุชุนุทูŠ

986
01:39:03,220 --> 01:39:09,120
ุงู„ู€ sperm ูˆุงู„ู€ egg ูˆุงู„ู€ ova ูˆูƒุฐุงุŒ ุจุชู„ุงู‚ูŠ ุฅู†ู‘ู‡ ู…ุณุชุญูŠู„

987
01:39:09,120 --> 01:39:15,380
ุงู„ู…ุฑุจุทูŠู† ู‡ุฐูˆู„ ุงุซู†ูŠู† ู…ุน ุจุนุถ ูŠู†ูุตู„ูˆุง ุจุดูƒู„ ู…ู†ุงุณุจุŒ ูู„ู‘ุง

988
01:39:15,380 --> 01:39:20,810
ุงู„ู€ offspring cellsุŒ ุฅู„ุง ูŠุทู„ุน ูŠุง ุฃู…ุง ุฒูŠุงุฏุฉ ูŠุง ุฃู…ุง

989
01:39:20,810 --> 01:39:25,750
ู†ู‚ุตุงู†ุŒ ูˆุงุถุญุŸ ูู„ู…ุง ูŠูƒูˆู† ุงู„ู€ imbalance ุจุชุตูŠุฑ ุงู„ุฃู…ุฑุงุถ

990
01:39:25,750 --> 01:39:34,410
ุฃูƒุซุฑุŒ ุจุชูƒูˆู† ููŠู‡ ู…ุดุงูƒู„ ุฃูƒุซุฑุŒ ู‡ุฐุง ุงู„ู…ุทู„ูˆุจุŒ ุชู…ุงู…

991
01:39:34,410 --> 01:39:38,710
ุฅู† ุดุงุก ุงู„ู„ู‡ุŒ ุฅุฐุง ุฅู† ุดุงุก ุงู„ู„ู‡ ู†ู„ุชู‚ูŠ ูŠูˆู… ุงู„ุฃุฑุจุนุงุกุŒ

992
01:39:38,710 --> 01:39:44,710
ุจู†ูƒู…ู„ ุนู„ู‰ ุงู„ุญุงู„ุงุช ุงู„ุซุงู†ูŠุฉ ูˆุงู„ุฃู…ุฑุงุถ ุงู„ุซุงู†ูŠุฉุŒ ุงู„ู„ู‡

993
01:39:44,710 --> 01:39:49,020
ูŠุนุทูŠูƒู… ู…ุง ูŠุนุทูŠู‡ุŒ ุงู„ู„ู‡ ุนููˆูƒ ูŠุง ุฏูƒุชูˆุฑุŒ ูŠุนุทูŠูƒ ุฃู„ู ุนููˆ

994
01:39:49,020 --> 01:39:51,040
ุฃู‡ู„ุงู‹ ูˆุณู‡ู„ุงู‹ุŒ ุงู„ุณู„ุงู… ุนู„ูŠูƒู