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DISEASES

OF THE

BREAST

EDITED BY

Jay R. Harris, MD

Professor

Department of Radiation Oncology Harvard Medical School

Chair

Department of Radiation Oncology

Dana-Farber Cancer Institute and Brigham and Women’s Hospital

Boston, Massachusetts

Marc E. Lippman, MD, MACP

Kathleen & Stanley Glaser Professor University of Miami Miller School of

Medicine Miami, Florida

Monica Morrow, MD

Anne Burnett Windfohr Chair of Clinical Oncology Chief, Breast Surgery Service

Memorial Sloan-Kettering Cancer Center

Professor of Surgery, Weill Cornell Medical College New York, New York

C. Kent Osborne, MD

The Tina and Dudley Sharp Chair of Oncology Professor of Medicine and Molecular and Cellular

Biology

Director, Dan L. Duncan Cancer Center Director, Lester and Sue Smith Breast Center Baylor College of Medicine

Houston, Texas

Senior Executive Editor: Jonathan W. Pine, Jr.

Acquisition Editor: Julie Goolsby

Senior Product Development Editor: Emilie Moyer Senior Production Product Manager: Bridgett Dougherty Senior Manufacturing Coordinator: Beth Welsh Marketing Manager: Stephanie Manzo

Senior Design Coordinator: Teresa Mallon

Production Service: SPi Global

Copyright © 2014 by Wolters Kluwer Health

Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com

First Edition © 1996 Lippincott-Raven Publishers Second Edition © 2000 Lippincott Williams & Wilkins Third Edition © 2004 Lippincott Williams & Wilkins Fourth Edition © 2010 Lippincott Williams & Wilkins

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above- mentioned copyright.

Printed in China

Library of Congress Cataloging-in-Publication Data

Diseases of the breast (Harris)

Diseases of the breast / edited by Jay R. Harris, Marc E. Lippman, Monica Morrow, C. Kent Osborne. — Fifth edition.

p. ; cm.

Includes bibliographical references and index. ISBN 978-1-4511-8627-7

I. Harris, Jay R., editor of compilation. II. Lippman, Marc E., 1945- editor of compilation. III. Morrow, Monica, editor of compilation. IV. Osborne, C. Kent, editor of compilation. V. Title.

[DNLM: 1. Breast Neoplasms—diagnosis. 2. Breast Diseases. 3. Breast Neoplasms—therapy. WP 870] RC280.B8

616.99449—dc23

2013036272

Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, com- pleteness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner.

The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing

research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug.

Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice.

To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300.

Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service represen- tatives are available from 8:30 am to 6 pm, EST.

10 9 8 7 6 5 4 3 2 1

To the many talented and dedicated laboratory and translational investigators and clinical researchers who have been committed to the breast cancer problem and have contributed to the

substantial progress made in recent decades in fighting this disease.

In memory of Jonathan Pine, our highly esteemed editor, who left all of us much too soon.

Albert J. Aboulafia, MD, FACS, MBA

Director, Sarcoma Services Alvin and Lois Lapidos Cancer

Center

Department of Orthopaedic Surgery Sinai Hospital

Assistant Clinical Professor University of Maryland Baltimore, Maryland

David H. Abramson, MD, FACS Professor of Ophthalmology Weill Cornell Medical Center

Chief, Ophthalmic Oncology Service Department of Ophthalmic Oncology Memorial Sloan-Kettering Cancer

Center

New York, New York

Brian M. Alexander, MD, MPH

Assistant Professor of Radiation Oncology

Harvard Medical School

Disease Center Leader, Radiation Oncology

Center for Neuro-Oncology Department of Radiation Oncology Dana-Farber/Brigham and Women’s

Cancer Center Boston, Massachusetts

Kimberly H. Allison, MD Associate Professor of Pathology Department of Pathology

Stanford University Medical Center Stanford, California

Benjamin O. Anderson, MD, FACS

Director

Breast Health Clinic

Seattle Cancer Care Alliance (SCCA) Professor of Surgery and Global Health

Medicine

University of Washington Seattle, Washington

Carlos L. Arteaga, MD

Professor of Medicine and Cancer Biology

Associate Director for Clinical Research

Director Breast Cancer Program Department of Medicine (Oncology) Vanderbilt-Ingram Cancer Center Vanderbilt University

Nashville, Tennessee

Nils D. Arvold, MD

Assistant Professor

Department of Radiation Oncology Harvard Medical School

Attending Physician

Department of Radiation Oncology Dana-Farber/Brigham and Women’s

Cancer Center Boston, Massachusetts

Alan Ashworth, FRS, FMedSci

Chief Executive

The Institute of Cancer Research London, United Kingdom

Aditya Bardia, MBBS, MPH Attending Physician Massachusetts General Hospital

Cancer Center Harvard Medical School Boston, Massachusetts

Christopher A. Barker, MD

Assistant Member

Department of Radiation Oncology Memorial Sloan-Kettering Cancer

Center

Assistant Attending Radiation Oncologist

Department of Radiation Oncology Memorial Hospital for Cancer and

Allied Diseases New York, New York

José Baselga, MD, PhD

Physician-in-Chief