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PMC11698348
In brief, mouse skin was dissected using Trypsin-EDTA (0.25%) and incubated for 2 hours overnight at 4°C.
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PMC8584666
Furthermore, the secreted soluble GPI-80 from PC3 cells was co-localized with exosome markers, and soluble GPI-80 was detected in the plasma of high-risk group prostate cancer patients.
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PMC6461034
Per sample, a network of inferred kinase–substrate relations annotated with INKA scores is visualized using the R package “network” (Butts, 2008).
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PMC9429973
These results supported the FDA approval of asciminib as a new treatment option for pts with CML-CP with T315I (NCCN 2021).
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PMC11252553
The background values (non-irradiated and untreated samples) have been subtracted from the data shown in the graph Figures 5-7.
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PMC9429973
Median time after first infusion was 4 months and 38% received a second lymphodepletion regimen.
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PMC7081114
Microtubules and kinesins play roles in intercellular signal transduction, transport, malignant tumorigenesis, and tumor progression, invasion, and metastasis.
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PMC11640555
During GBM progression, uncontrolled proliferation of cells leads to the instability of the tumor microenvironment with tumor cells also invading surrounding tissue up to the BBB, where results of said invasion are characterized by loss of integrity and breakdown of tight junctions of the endothelium, contributing to the extravasation of the tumoral cells expressing cytokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and growth factors .
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PMC9541067
j–l The values of the band intensity represent the densitometric estimation of each band normalised by β-actin in (b–f, respectively). (*
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PMC9429973
Image: Summary/Conclusion: Among RUX-treated pts, lower RUX doses, comorbidities and no spleen response are significant predictors of hospitalization.
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PMC9429973
As a result, patients previously diagnosed as smoldering MM (SMM), were considered to have MM requiring treatment if they had a FLC ratio ≥100.
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PMC11696659
A random-effects meta-analysis showed that patients with lung cancer had shorter telomere length than controls, with an odds ratio of 1.13 (95 % CI: 0.82–1.81, p = 0.46) .
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PMC11661040
The activation of the wnt/β-catenin signaling pathway contributes to the metastasis of osteosarcoma cells(Wen et al. 2021); however, our study did not demonstrate any impact on the metastatic ability of these cells.
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PMC9352806
Lipid droplets (LDs) are cytoplasmic organelles containing mostly TAG, surrounded by a monolayer mainly of PC and PE.
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PMC11088135
LncRNA NUTM2A-AS1 was negatively correlated with miR-376a-3p.
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PMC11064533
WT without gentamicin stress (median value normalized to 100%), and the four genes are shown with (red bar) and without (blue bar) gentamicin when adhered to 5637 cell line. (
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PMC11087766
Then, 200 μL of culture was mixed with 5 mL 0.35% LB top agar ± 0.1% arabinose and poured onto a plate with the appropriate antibiotic.
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PMC8992508
A sulfonamide group was introduced instead of an amide function to improve aqueous solubility and this modification led to specific P-gp inhibitors.
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PMC11036064
After seeding 5×10 transfected and non-transfected cells into a six‐well plate and incubating for 14 days and treatment, the cells were stained using crystal violet.
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PMC11684821
CD8 engages a largely invariant site on MHC-I to augment recognition of the peptide MHC by the highly variable αβ T cell receptor (TCR) (2, 3).
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PMC11680578
Fig. 7Effect of paclitaxel (PTX) and rosiglitazone (RGZ) on the expression of PPAR-γ protein expression in SKOV-3 ovarian cancer cells.
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PMC11267830
e Moreover, RBM39 knockdown significantly inhibited the proliferation of J. gamma1 and Jurkat cells.
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PMC11337594
This study aimed to elucidate the intrinsic mechanism of this inhibitory effect, which may facilitate the discovery of novel chemotherapeutic agents.
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PMC11509224
The 4,8-dimethyl-5-(1,3,3-trimethylcyclohexyl)-octahydro-1H-2λ-isoquinoline heterocyclic skeleton found in oxeatine, which features a δ-lactam with the nitrogen atom bridging C-6 and C-15 of a rearranged spongian carbon framework, was unknown in nature or from synthesis.
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PMC10421378
Tubes containing 9 mL of solvent (0.9% NaCl) were prepared, and then 1 mL of the sample was added into the first tube so that a dilution of 10 was obtained.
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PMC11377827
CA9: control vs. USP43 sgRNA *P = 0.0444, control vs. Set1B sgRNA **P = 0.0056.
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PMC11047729
Not only that, but also, vitamin D is effective in different types of leukemias, which makes it quite versatile.
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PMC9429973
Results: We identified twelve CLL cases with IGLV3-21.
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PMC9429973
A similar trend was observed according to karyotype complexity represented by number of aberrations apart from del(5q).
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PMC11545868
It also exhibited antitumor effects by inhibiting peptidyl-prolyl isomerase-1 (Pin-1), which is overexpressed in human malignancies .
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PMC9429973
This is in line with the general population.
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PMC11704834
To express exogenous TLE1 in A549 cell line, parental cells were transduced with lentiviral GFP-TLE1 or the empty control GFP construct (Horizon Discovery) (8,9).
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PMC11763111
Three or five days later, 2.5 × 10 CAR-T cells and 2.5 × 10 NK cells were injected intravenously at a 1:1 ratio.
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PMC9780037
The biosensors for quantification of cyt c in the serum demonstrate the versatility of the methodologies available to detect this protein in biological samples.
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PMC11397654
Notably, the most active pyrrolidine-substituted azacalixarenepyrimidine 72j featured inhibitory properties comparable to those of the benchmark drug doxorubicin while being considerably less toxic for the normal human foetal hepatocyte line L-02.
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PMC11746948
Furthermore, the GPX4 R152H mutation’s association with SSMD suggests that targeting APT2 to maintain GPX4 palmitoylation may enhance GPX4-R152H activity, proposing APT2 as a viable target for therapeutic intervention.
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PMC11618052
Quinazolines' anticancer properties can be traced back to Paganini (vaccine), a naturally occurring quinazoline discovered in 1888.
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PMC11657695
The horizontal line indicates the log2FoldChange.
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PMC11310713
However, estrogen and progesterone induce the proliferation of hormone receptor-positive breast cancer cells compared to estrogen alone .
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PMC10669966
Therefore, we decided to further investigate its role in LPS.
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PMC11738017
Anti-BCMA TCE cytotoxicity is dependent on the ratio of T-cell engagement per mBCMA molecules that is factorized by the combinatorial effect of sBCMA, mBCMA, E:T ratio, and TCE dosing.
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PMC11218145
OCR traces of control (black line) and TB-treated Ren cells expressed as picomoles of O2 per minute, under basal conditions and after the injection of oligomycin, FCCP, and Rot/AA.
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PMC11656380
All tumor cell lines and primary human peripheral blood mononuclear cells (PBMCs) listed in Table S1 were obtained from commercial sources and used in the study.
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PMC11599565
In line with this, both CD24 and EpCAM were not detected in “twin” cells, but were highly expressed in SKOV3 cells (Fig. 6, Panel B).
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PMC8382973
Stability of the 2P23 gel in complete growth medium was evaluated in a biological assay as a function of temperature.
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PMC7039683
Zebrafish embryos were maintained at 28.5°C, and staged by hours or days post-fertilization (hpf or dpf).
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PMC11672881
Its downregulation in response to TQ treatment is, therefore, significant, as it may help inhibit tumor progression and improve the therapeutic response .
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PMC9960565
H-NMR (400 MHz, D2O) [ppm]: δ = 2.65 (Ho, t, 36H), 2.85 (Hc + Hi, t, 19H), 3.20 (Ha + Hg, m, 14H), 3.30 (Hb + Hh + Hn, m, 56H), 3.52 (Hm, t, 18H), and 3.68 (Hf + Hl, m, 23H).
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PMC8316344
Does the expression level of TRIB2 determine the degree of the sensitivity to the induction of ferroptosis in Bel-7404 and SK-Hep1 cells?
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PMC9429973
Flow cytometry and western blotting assessed the combinational effect of Calcineurin/NFAT inhibitors and BTZ on MM cells.
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PMC11695623
The possible biological functions and signal pathways of DCUN1D5-related genes were analyzed by bioinformatics.
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PMC11721587
WB analysis of Ulk3 SUMOylation and maturation in NIH3T3 cells expressing the indicated Ulk3 constructs and treated with Shh. (
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PMC9429973
Methods: DIRECT enrolled newly diagnosed CP-CML pts.
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PMC9429973
The B-cell maturation antigen (BCMA)-directed CAR T cell therapy idecabtagene vicleucel (ide-cel, bb2121) received regulatory approval in the US for pts with RRMM with ≥4 prior lines of therapy (LOT), including an IMiD agent, PI, and anti-CD38 mAb, and in Europe and Japan for pts with RRMM with ≥3 prior LOTs including an IMiD agent, PI, and anti-CD38 mAb.
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PMC9429973
Discrepancies were discussed to be included or excluded.
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PMC11352746
This makes these instruments superior for detailed cellular analysis and imaging clarity.
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PMC10831439
PD-1 expression on CD19-CAR-iNKT cells and untransduced iNKT cells on contact with Raji cells (left, n=3) and representative data for one donor (right).
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PMC11391695
Following the removal of cell fragments caused by the scratch, the cells were washed three times with PBS buffer and the cell culture solution was drained off.
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PMC9429973
One patient lost 100% recipient STR profile and become chimera with 43% of the recipient.
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PMC7452526
Effect of silver nanoparticles in the induction of apoptosis has been studied previously and different mechanisms of the potential cytotoxicity of silver nanoparticles have been investigated such as activation of apoptotic caspases, DNA fragmentation, nuclear fragmentation, ROS generation, leakage of LDH and also altering mitochondrial membrane potential .
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PMC9096373
The paraffin-embedded tissues were fixed in 10% formalin and sliced into 5-µm-thick sections using a microtome (Leica Biosystems, Wetzlar, Germany).
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PMC11655536
Moreover, other cell death pathways involving lysosome in addition to apoptosis may also participate in HA-induced cell death in MM cells.
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PMC10142392
The S-PCL-PDMAEMA delivered drugs to the nuclei of U87 cells during a 3-hour incubation, but L-PCL-PDMAEMA accumulated most of them in the cytoplasm.
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PMC7868205
Techniques such as energy dispersive X-ray analysis and inductively coupled plasma-optical emission spectrometry (ICP-OES) were used for establishing the elemental composition.
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PMC9429973
Overall (OS) and progression free survival (PFS) were calculated by Kaplan-Meier method and comparisons done by the log rank test.
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PMC10165258
Effect of individual drugs on EwS spheroids (A) Timeline of the assay.
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PMC11696659
This model demonstrated a positive predictive value (PPV) of 0.79 (95 % CI, 0.65–0.88) and a negative predictive value (NPV) of 0.83 (95 % CI, 0.63–0.94) for prediction of lung cancer (Table 2).
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PMC9429973
In univariable analysis, paranasal cavity lesion was a high-risk factor for sCNSi (subdistribution hazard ratio, 4.34 [95% confidence interval, 1.28–14.73], p = 0.018).
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PMC11269792
The bioinformatics website starbase predicted the existence of potential binding sites for miR-6838-5p and CDV3 (Fig. 5A).
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PMC9429973
S. Arza Apalategi, B. Heuts, S. Bergevoet, S. van Heeringen, J. Jansen, J. Martens, B. van der Reijden Laboratory Medicine, Laboratory of hematology, Radboudumc; Molecular Biology; Molecular Developmental Biology, Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands Background: The MLL-AF9 protein contributes to acute myeloid leukemia (AML) development through transcriptional activation of oncogenic gene programs.
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PMC11733919
Similarly, the use of nanocarriers functionalized with specific moieties to selectively recognize senescent cells can also be considered as a promising strategy.
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PMC11681005
Notably, as 5637 cells expressed high levels of KRT6A/B, we considered them basal‐like cell lines that mimic TPCS.
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PMC5925824
Data are representative of multiple experiments and donor T cells/DC pairs.
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PMC11585587
Treated with RA, the Western blot analysis showed that the expression levels of Bim, Cleaved Caspase 3/9, and Cleaved PARP were increased, and the expression level of Mcl-1 was decreased in MM cells.
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PMC9429973
The respective advantages of alternative donor such as UD or HaploD are yet to be precisely assessed notably in older population including the search and identification process.
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PMC2193049
Finally, a sequence encoding a peptide tag derived from the influenza ha was inserted between the GFP and Ub moieties to permit the detection and quantitation of GFPha–Ub fusion.
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PMC11092382
Jin’s group demonstrated that sophocarpine effectively inhibited the attachment and penetration of EV71, therefore preventing the entry of the virus into the cells.
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PMC9684669
Moreover, a synergistic effect of terfenadine and anticancer drugs has been demonstrated in the treatment of breast cancer and lung cancer (20, 21).
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PMC11657744
AurA expression is regulated at both transcriptional and post-transcriptional levels, with ubiquitin-proteasome-dependent degradation mediated by anaphase-promoting complex during mitosis, typically reaching its lowest level at the G1 phase .
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PMC10745221
A methionine-restricted diet in a mouse model of colorectal carcinoma was shown to decrease m6a mRNA methylation in cancer cells .
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PMC9429973
Durable responses with axi-cel were greatest in tumors with prominent B-cell features, but were superior to SOC regardless of these features.
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PMC8143558
Solanum macrocarpon L. and Balanites aegyptica L. Delile have been reported to exhibit high hemolytic activity.
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PMC10759659
P < 0.05, ** P < 0.01, *** P < 0.001) To verify the accuracy of the methods, we first analysed the mRNA and protein levels of ARID1A in the CHCC-HBV cohort between the deficient and normal functioning groups.
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PMC10940855
J, Multiple myeloma cells transduced with gRNA-EFNB2 or gRNA-control were cultured with increasing concentrations of the STAT5 inhibitor 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide 3-pyridinecarboxylic acid (STAT5i) for 24 hours, then BrdU incorporation analysis was performed.
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PMC9429973
No clear link of platelet desialylation with multi-refractory ITP, the bleeding phenotype or thrombosis history was found.
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PMC5839394
The polysaccharide fraction was washed twice with milliQ water and the polysaccharide was precipitated with 70% ethanol solution overnight at 4°C.
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PMC11240448
The first step in the cSTAR pipeline is to distinguish different cell states employing ML-based classifiers.
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PMC10840195
Twist not only affects both the Wnt/β-catenin and EMT signalling pathways but also has highly consistent predicted interacting proteins with EMT and Wnt signalling pathway interacting proteins (Fig. 3A, B).
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PMC11666785
Recently developed MINFLUX and MINSTED techniques which is a combination of SMLM and STED has demonstrated imaging of nuclear-pore complex with high spatio-temporal resolution.
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PMC11653552
The Hippo signaling pathway is a particularly exciting area of research in both solid and hematologic tumors .
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PMC11209164
Here, we observed that both TPF and DMF significantly increased Ad5-GFP transduction in several cell lines 70 h post transduction.
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PMC11787355
Previously, we have isolated and validated vaccine-induced glioma-reactive TCRs targeting the tumor-associated antigen, NLGN4X, and neoantigens, IDH1R132H, H3K27M, and CICR215W/Q. In a multinational European glioblastoma immunotherapy clinical trial, Glioma Actively Personalized Vaccine Consortium 101 (GAPVAC-101), newly diagnosed glioblastoma patients were immunized with a warehouse of unmutated glioblastoma-associated peptides (APVAC1), and a warehouse of individual-specific mutated peptides (APVAC2).
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PMC11180402
These results demonstrate that miR-129 induction by ISO is responsible for the inhibition of SNHG1, SOX2, MMP-2, and MMP-9 expression and the induction of PTEN expression in 5637 cells, further mediating the inhibition of BMIBC invasion and anchorage-independent growth in 5637 cells.
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PMC11473750
Copy number (relative ploidy), and gene dependency (CERES) data for RNF121 were first obtained from DepMap and then filtered using R/R Studio (v1.1.456) for disease types/cell lines common to all data sources as well as those disease types that had >1 cell line present.
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PMC11634794
This indicates that LAMP1 may serve as a predictive marker for EGF-induced cell overproliferation (17).
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PMC10523483
Future investigations on how H1.2 interacts with NRF2 to fine-tune nuclear NRF2-mediated transcription process are desired.
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PMC9878562
DOHH2 cells migrated more efficiently than VAL-wt, but also displayed enhanced chemokinesis.
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PMC11758416
Note: Other cell dyes including CellTrace Violet (Thermo Fisher Scientific, cat: C34557) or CellTrace FarRed (Thermo Fisher Scientific, cat: C34564) can be used to identify the L cells if CFSE is not a good option.a.
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PMC11321678
If cell debris and large clumps were observed, pass through a 40 µm cell strainer again.
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PMC11347429
Analysis of differentially expressed genes (DEGs) showed 701 upregulated and 367 downregulated genes when contrasting all infected patients versus healthy controls ( Figure 2A ; complete list of DEGs in Data file 6 ).
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