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OTAR3088
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PMC11767725
These lipid alterations directly affect sebum composition and the skin’s ability to sustain commensal microbiota .
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PMC11172027
NALM was only able to show a reduction in cell growth of the Jurkat cells at the highest incubation time.
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PMC9429973
Methods: The ARC Initiative is a multicenter chart review study of adult pts with AML who received VEN ≥April 2016 (VEN cohort) or non-VEN regimens ≥May 2015 (control cohort).
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PMC8777939
The tumor volume (cm) was calculated using the formula 0.5 × L × W (L = length, W = width).
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PMC11155445
Tudor et al. synthesized a series of Cu(i) complexes with acyl thiourea and phosphine ligands by adding N-benzoyl thiourea ligands (66 or 67) to the solution of precursors [CuCl(PPh3)4] or [CuBr(PPh3)3] in toluene (Fig. 14).
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PMC9874064
To sum up, after NP-Pt-USP1i was taken up by tumor cells, cisplatin and C527 could be released through the polymer degradation, nanoparticle dissociation, and chemical reduction of the platinum (IV) prodrug to cisplatin.
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PMC11365983
Involvement in stroke, primary open angle glaucoma, and the most severe subtype of breast cancer, demonstrates FOXC1’s additional contribution to common late-onset diseases.
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PMC9545714
ALOX5 can also act on the higher omega‐3 essential fatty acids (eicosapentaenoic acid and docosahexaenoic acid), and some of these products may be anti‐inflammatory.
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PMC11155445
Compound (134d) was effective only when used in high concentration and only decreased the production of TNF after 10 min of illumination, and all the remaining acyl thioureas were not effective both in dark and illuminated situations.
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PMC11763126
Western blot analysis showed that knocking down YTHDF2 significantly increased TRPM3 protein levels, while overexpressing YTHDF2 significantly decreased TRPM3 protein levels (Fig. 7B).
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PMC11755467
Next, we determined if the anti-HIV-1 effect of Enoxacin was at least partly attributed to reduced pro-HIV-1 miRNA hsa-miR-132-3p levels.
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PMC11799978
In E, * indicates comparison with 0 μg/mL of NaHCO3 and # indicates comparison with control.
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PMC11711127
However, analysis of steady state DCs that induced anergy or deletion of T cells reveals that they present intermediate levels of co-stimulatory ligands like CD86 and ICAM1, suggesting a more complex picture (18).
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PMC11024707
mi-RNA-151a was significantly associated with sound sensitivity and mi-RNA-28 with echolalia.
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PMC4443654
Both cell-type-specific and general constituents of boundaries may have utility in the biomedical interpretation of genomic variation in noncoding regions of the genome.
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PMC11694066
I, Tumor volume at the time of mice sacrifice.
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PMC11531744
So, single-cell sequencing technology was used to reveal the changes in the immune microenvironment of OV.
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PMC9429973
Risk stratification system for adults is unfit for children.
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PMC11371747
Both compounds are relatively good substrates of PCFT, which explains the important role of PCFT as folate transporter in the gut.
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PMC11707832
Similarly, Patryk Lipin ´ski reported a case where a girl diagnosed with α-mannosidosis at 3 years old subsequently developed Sjögren’s syndrome at 7 and SLE at 9 years of age.
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PMC9429973
Concerning COVID-19 severity, 33 of 56 patients needed C-PAP or tracheal intubation.
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PMC11791264
Statistical analysis was conducted with the Prism 8 (GraphPad Software).
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PMC9844987
The neural network model uses as input one-hot-encoded DNA sequences (A = , C = , G = , T = ) from the human reference genome (hg38) to predict low and highly variable promoter activity as output.
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PMC9429973
The overall response rate (ORR) was 78% (n=83), with 31% complete response (CR; n= 33) in DRD.
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PMC8873393
Intriguingly, the variance in gene expression between the individual sample derived from the chromatin extract is substantially greater than the samples from the cytoplasmic fraction, suggesting a particular impact of UV irradiation on the chromatin-enriched transcriptional programs (Fig. 2E).
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PMC11365983
Primers used for qPCR genotyping are provided in Supplemental methods (Table S6).
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PMC9429973
The standard turn-around time for the MTB pipeline after sampling was 21 days.
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PMC9429973
Bloodstream infection caused by Kl.
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PMC11626627
We further investigated how TWIST1, as a TF, regulates the expression of ERβ.
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PMC7602170
GIST cells were destroyed by the synergistic effect of imatinib and autophagy inhibition by RNAi-mediated silencing against ATG7 and ATG12 .
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PMC11576293
Figure 5 shows a successful single crystal X-ray image obtained using derivative 14.
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PMC10411253
Supplementary Information is linked to the online version of the paper on the Asian Journal of Andrology website.
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PMC2614416
After adjusting to room temperature, 1.5 μL of 200 mM iodo-acetamide (IAA) in 100 mM ABC (final concentration of 15 mM IAA) was added.
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PMC9429973
In CAPTIVATE pts treated with I+V, a rapid and significant decrease in circulating CLL cells was observed within the first 3 cycles of Ven tx initiation (Fig 1A, cycle 7).
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PMC9429973
Results: In total, 186 patients were referred to the tumorboard, 57 were not approved for axi-cel during the online tumorboard meeting, mostly (n=23) due to rapid progression (RP).
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PMC11591030
As shown in Figure 2, under non-stress conditions, supplementation with 150–200 µg/mL of AOP significantly increased the SOD enzyme activity and decreased the 8-OHdG levels compared to the control group, with no significant difference observed compared to the VA treatment group (p < 0.05).
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PMC9429973
Aims: To compare the efficacy of nivolumab (Nivo) 40 mg therapy with 3 mg/kg for patients with r/r cHL.
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PMC10237474
HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
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PMC10024132
Consequently, the labile nature of this drug necessitates that it be administered by continuous intravenous infusion for up to 4 weeks per cycle in order to maintain adequate blood concentrations and sustain T cell-mediated lysis of B cells.
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PMC11394227
Subsequently, non-specific binding was blocked with 1% BSA for 1 h. Samples of the pembrolizumab standard (DIMA BIOTECH) and diluted culture supernatant were then added to the appropriate pore for 1 h with a PBST wash plate.
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PMC11472639
∗indicates a significant difference at p < 0.05, ∗∗∗indicates a significant difference at p < 0.001.
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PMC9429973
Of all positive cases determined by local adjudications, 30% will be randomly selected for central adjudication by independent adult and pediatric adjudication committees.
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PMC9545474
Compounds were administered to non‐tumour‐bearing animals on days 0, 1, 2, 3 and 4.
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PMC11088135
Seeding 3000 cells into each well of a 96-well plate and the cells were transfected as described above.
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PMC11394227
The experimental results demonstrated no significant change in the volume size of the four cell lines (Figure 5A).
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PMC11604015
In their phase I clinical study (ISRCTN15323014), three patients with relapsed T-ALL who received BE-CAR7 showed morphological remission within 28 days .
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PMC11694346
As shown in Fig. 7, the results indicate that the LUMO (Lowest Unoccupied Molecular Orbital) energy level of Cl-DNBS (−4.21 eV) is positioned between the HOMO (−5.86 eV) (Highest Occupied Molecular Orbital) and LUMO (−2.99 eV) of BT-NH.
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PMC11779605
injected with saline starting on the same day as the spheroid injection and then daily throughout the experiment.
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PMC11794568
TFAM is a key nuclear-encoded protein involved in the replication, transcription and maintenance of mitochondrial DNA (mtDNA).
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PMC8343815
In Figure-1(b), an average size of 40 nm is apparent for spherical AuNPs.
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PMC9429973
These results indicate that targeting LSCs with NUC-7738 may offer a successful therapeutic strategy for treating patients with leukemia.
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PMC5673060
These differences suggest that there are likely to be additional dependencies associated with acquired resistance to dasatinib and pazopanib which can be exploited for cancer therapy.
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PMC11637276
The chemotaxis tool plugin in Fiji/Image J (https://ibidi.com/chemotaxis-analysis/171-chemotaxis-and-migration-tool.html) was used to calculate the velocity and directionality of migrating cells.
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PMC10605143
Surprisingly, in our model, the increase in HSF1 expression did not affect the stem cell-like characteristics of MD-MB-468 breast cancer cells (which exhibit CD44/CD24) but facilitated their migration and growth in Matrigel.
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PMC11291697
Although further investigations are needed to reinforce the genotype-phenotype correlation, we propose that GTDC1 disruption may alter crucial neurodevelopmental processes as a consequence of modifications affecting the glycine metabolism (thus the NMDAR signalling) and the physiological balance between pro- and anti-inflammatory cytokines/chemokines.
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PMC9429973
In 2 of the 3 patients whose CNI was not discontinued, another type of CNI was used and the seizure did not recur.
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PMC10705095
The analysis revealed that the α-globin genes are located along a 20-kb distal segment of chromosome 16 in the following order from upstream to downstream region: HBZ, HBM, HBA2, HBA1, and HBQ1 (Figure 1a).
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PMC10729469
Adoptive transfer of either TCRAβ-Tregs or polyclonal Tregs to APP/PS1 mice reduced dense amyloid plaque deposition in both the cortex and hippocampus compared with untreated APP/PS1 mice (Fig. 5C and D).
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PMC10523483
Given the importance of these regulations in cancer development, the roles of H1.2 have attracted attentions in cancer research.
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PMC10538569
Further, iDC and CEMss GPI-GFP cell-cell synapse can be seen where GPI-GFP is enriched on iDCs suggesting that transfer of GPI-GFP can occur from GPI-GFP transduced CEMss to iDCs after 2 hours of co-culture and may occur through cell-cell synapse engagement ( Figure 7A ).
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PMC11583010
Similar distribution and PD results were found during treatment of the CDX SUM190 mice with ETx-22 (Supplementary Fig. S5).
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PMC10218459
After CPP exposure, 800 µL of warm full medium containing the corresponding cytostatic agent was added to each well prior to incubation at 37 °C.
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PMC6268318
The crude extract inhibited the contractions induced by acetylcholine and histamine in the guinea-pig ileum in a concentration-dependent manner.
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PMC8973085
In the case of 4dk7 for human liver, all tested pyridine derivatives showed interactions with docking scores ranging from −7.6825 to −4.5118 (Table 3).
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PMC9429973
As such, laboratories will need to ensure continued adoption to reflect new data reporting methods, treatments and standards of care for CLL patients.
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PMC9429973
A favorable low rate of PRI was also observed in this series which could be explained by the adequate management of the devices at our institution with a weekly follow-up nurse control.
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PMC11467800
For the metastasis or the population kinetics assays; 2 days post‐fertilization (dpf) embryo of Casper strains were dechorionated with pronase and anesthetized with 0.04 mg/mL tricaine (Sigma‐Aldrich) in embryo medium E3.
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PMC11694625
So, it is vital to quantitatively detect them in biological samples.
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PMC11489351
Assays were run in technical duplicates for each condition and averaged to generate a data point for each biological replicate.
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PMC11675244
Many facts suggest that activated Wnt signaling plays a key role in the development of many human cancer types, driving tumor proliferation, aggressive behavior, and metastasis.
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PMC9429973
Fluorescence activated cell sorting (FACS) staining was performed on the MACSQuant VYB (Miltenyi Biotec) or Fortessa (BD).
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PMC7887261
g Overproduction endogenous DNA damage assay scheme.
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PMC5173112
For colony forming, single cells were seeded onto 6-well plates (Corning) at a density of 1000 cells/well and then incubated at 37°C.
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PMC11468365
In the molecular graph, the atom is represented by , and the chemical bonding between the atom and atom is represented by .
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PMC11675244
The Wnt pathway was first discovered in 1982 by Nusse et al., as an attempt to investigate the genetic modifications involved in the development of breast cancer in mice .
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PMC6650823
Highlighted by Luigi A. Agrofoglio Nucleoside analogs are used not only as building blocks in the genetic code but also as biosynthetic intermediates, energy donors, metabolic regulators, and cofactors in enzymatic processes.
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PMC9429973
Image: Summary/Conclusion: Maturation-associated intra-tumor drug response heterogeneity is a strong predictor of clinical response to first-line intensive induction chemotherapy in AML.
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PMC9429973
Results: The median time of neutrophil recovery in both groups was 13 days, and the cumulative recovery rate of neutrophils on the 30th day was 100%.
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PMC11637276
Indeed, MAPK14 is up-regulated in BRAF-inhibition-resistant melanoma in mouse models , while MAPK11 abrogation promotes radiosensitivity in A549, MCF7, and HCT-116 cells .
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PMC9812014
To determine the inhibitory stage of HHT, time-of-addition tests were performed, and it was discovered that HHT does not block VSV cell entry, and targets a late stage of VSV viral replication thereby inhibiting it .
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PMC11297139
Data are presented as the mean ± SEM. ***
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PMC11753541
This is thought to be important for trypsin activation and subsequent separation of the epidermis from the dermis.
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PMC11658074
Cells treated with CD151-positive AT-EVs presented increased red fluorescence, indicating faster uptake of EVs (Fig. 6g, h), as well as elevated CD151 expression (Fig. 6g, i).
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PMC11087766
Colocalization of mCherry and sfGFP can be seen in yellow.
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PMC11387401
Assay A was performed on uninfected Jurkat T-Rex cells with anti-FLAG antibody.
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PMC10523483
Structure of a nucleosome in complex with linker histone H1 (PDB ID: 5NL0) and schematic structures of five main somatic human H1 variants. (
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PMC9429973
We also observed a positive association between cardiovascular risk factors (CVRF) and thrombotic events (Table 1), as expected.
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PMC10033453
t-Distributed stochastic neighbor embedding (t-SNE) analysis performed on live CD45+ TILs. (
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PMC10170482
Alexander and HepG2 cells were cultivated and stained as described in panel D. The ImageJ software (NIH) was used for image processing and quantification.
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PMC9429973
Despite improvements in overall survival, relapse rates in myeloid malignancies remain high.
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PMC11782508
The column was washed with phosphate citrate buffer (pH 6.0) and eluted with NaCl solution (0, 0.2, 0.3, and 0.5 M) in the same buffer at a flow rate of 1.0 mL/min.
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PMC11723947
The three different isoforms, called HP1α, HP1β and HP1γ in mammals, contain two conserved structural and functional motifs.
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PMC9918897
After the treatment period, each anesthetized mice underwent final samplings that included body- and tumor-weight measurement, blood sampling, and gross pathology.
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PMC5839394
In particular, the majority of the identified proteins can be classified into 5 different groups namely: mitochondrial proteins, endoplasmic reticulum lumen proteins, proteins involved in regulation of apoptosis, proteins involved in the response to oxidative stress and glycolytic proteins.
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PMC9429973
However, a major roadblock for the clinical application and translational research on HSCs is our limited potential for ex vivo HSC expansion.
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PMC10877303
Moreover, the top three compounds exhibited better binding energy along with better stability and firmness than the inhibitor (Nafamostat), which was further confirmed by the binding free energy calculation.
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PMC10728200
At the last follow-up, recurrence occurred in 34 cases (8.1%) and death in 4 (1.0%) cases.
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PMC8875242
It has been suggested that both antiretrovirals and DAA may inhibit intestinal ABCB1, but their activity in this respect has not been studied thoroughly.
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PMC7553912
OSM signaling thus promotes renal fibrosis in the process of kidney stone formation.
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PMC10040136
Co-culture with MSC reduced the apoptosis rate of GIST (H, J) under IM treatment and reduced the proportion of G0/G1 phase cells while increasing the proportion of S phase cells (I, K).
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