OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Analysis of covariance (ANCOVA) models were conducted to adjust for age, sex, race, and baseline score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "covariance", "(", "ANCOVA", ")", "models", "were", "conducted", "to", "adjust", "for", "age", ",", "sex", ",", "race", ",", "and", "baseline", "score", "." ] } ]
PMC7553912	The apparent molecular weights are indicated on the right. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apparent", "molecular", "weights", "are", "indicated", "on", "the", "right", ".", "(" ] } ]
PMC11470999	We also preliminarily elucidated the structural mechanism of PF‒CIP2A‒VHL complex formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "preliminarily", "elucidated", "the", "structural", "mechanism", "of", "PF‒CIP2A‒VHL", "complex", "formation", "." ] } ]
PMC11708541	In the 1960s and 1970s, research began to reveal its potential therapeutic uses, particularly in neurology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "1960s", "and", "1970s", ",", "research", "began", "to", "reveal", "its", "potential", "therapeutic", "uses", ",", "particularly", "in", "neurology", "." ] } ]
PMC11720107	The experiments showed that the Harnaś garlic cultivar significantly increased LDH release from BJ cells only at the highest concentration (1.000 mg/mL), with an increase of 16.0% compared with the control (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiments", "showed", "that", "the", "Harnaś", "garlic", "cultivar", "significantly", "increased", "LDH", "release", "from", "BJ", "cells", "only", "at", "the", "highest", "concentration", "(", "1.000", "mg/mL", ")", ",", "with", "an", "increase", "of", "16.0", "%", "compared", "with", "the", "control", "(", "Figure", "2A", ")", "." ] } ]
PMC10114490	This clustering also evidences the similarities between cells from different PD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "clustering", "also", "evidences", "the", "similarities", "between", "cells", "from", "different", "PD", "." ] } ]
PMC11317131	Briefly, CRISPResso2 was run in HDR mode, discard_indel_reads flag was on and quantification window coordinates were set to 10 bp upstream of each nick site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "CRISPResso2", "was", "run", "in", "HDR", "mode", ",", "discard_indel_reads", "flag", "was", "on", "and", "quantification", "window", "coordinates", "were", "set", "to", "10", "bp", "upstream", "of", "each", "nick", "site", "." ] } ]
PMC11643491	In addition to increasing the uptake of the drug carrier by target cells, the increased energetic cost of uptake by non-target cells can minimize unwanted side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "increasing", "the", "uptake", "of", "the", "drug", "carrier", "by", "target", "cells", ",", "the", "increased", "energetic", "cost", "of", "uptake", "by", "non-target", "cells", "can", "minimize", "unwanted", "side", "effects", "." ] } ]
PMC11718817	DNA damage in PDAC cells leads to AIM2 inflammasome activation and—via the release of high mobility group protein 1 (HMGB1)—to the expression of PD-L1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "damage", "in", "PDAC", "cells", "leads", "to", "AIM2", "inflammasome", "activation", "and", "—", "via", "the", "release", "of", "high", "mobility", "group", "protein", "1", "(HMGB1)—to", "the", "expression", "of", "PD-L1", "." ] } ]
PMC11775197	Chiral phenoxyacetic acid analog (S)-3 acts as a partial agonist of PPARγ, blocks the cell cycle, inhibits cell proliferation, and induces apoptosis through PPAR-dependent mechanisms: upregulation of p21, and inhibition of c-Myc and cyclin D1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chiral", "phenoxyacetic", "acid", "analog", "(S)-3", "acts", "as", "a", "partial", "agonist", "of", "PPARγ", ",", "blocks", "the", "cell", "cycle", ",", "inhibits", "cell", "proliferation", ",", "and", "induces", "apoptosis", "through", "PPAR-dependent", "mechanisms", ":", "upregulation", "of", "p21", ",", "and", "inhibition", "of", "c-Myc", "and", "cyclin", "D1", "." ] } ]
PMC10969097	Regarding clinical trials, it was not possible to assess the Risk of Bias in the clinical trials with numbers NCT05763199 and RCT20190822044579N1, as the studies are still ongoing and do not yet have results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "clinical", "trials", ",", "it", "was", "not", "possible", "to", "assess", "the", "Risk", "of", "Bias", "in", "the", "clinical", "trials", "with", "numbers", "NCT05763199", "and", "RCT20190822044579N1", ",", "as", "the", "studies", "are", "still", "ongoing", "and", "do", "not", "yet", "have", "results", "." ] } ]
PMC11638764	The colors indicate the following: red represents upregulated proteins, blue denotes downregulated proteins, and black indicates proteins with no significant change compared to the DMSO control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colors", "indicate", "the", "following", ":", "red", "represents", "upregulated", "proteins", ",", "blue", "denotes", "downregulated", "proteins", ",", "and", "black", "indicates", "proteins", "with", "no", "significant", "change", "compared", "to", "the", "DMSO", "control", ".", "(" ] } ]
PMC11544122	Importantly, the loss in endocytosis was rescued by the re-expression of SNX9 alone (Fig. 3c and Supplementary Fig. S1i), reinforcing the requirement for SNX9 in CXCR4 endocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "the", "loss", "in", "endocytosis", "was", "rescued", "by", "the", "re-expression", "of", "SNX9", "alone", "(", "Fig.", "3c", "and", "Supplementary", "Fig.", "S1i", ")", ",", "reinforcing", "the", "requirement", "for", "SNX9", "in", "CXCR4", "endocytosis", "." ] } ]
PMC11803918	Hematoxylin and eosin (H and E) staining of the tumor tissues also showed more necrosis of the tumor in hybrid exosome-treated humanized mice (Figure 8E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hematoxylin", "and", "eosin", "(", "H", "and", "E", ")", "staining", "of", "the", "tumor", "tissues", "also", "showed", "more", "necrosis", "of", "the", "tumor", "in", "hybrid", "exosome-treated", "humanized", "mice", "(", "Figure", "8E", ")", "." ] } ]
PMC11240571	Conclusions: Exosomal PD-L1 emanates from bone and soft tissue sarcoma cells and is disseminated into the circulatory system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conclusions", ":", "Exosomal", "PD-L1", "emanates", "from", "bone", "and", "soft", "tissue", "sarcoma", "cells", "and", "is", "disseminated", "into", "the", "circulatory", "system", "." ] } ]
PMC11438317	These data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "indicate", "that", "LYP", "may", "modulate", "T", "cell", "activation", "by", "dephosphorylating", "several", "adaptor", "proteins", ",", "such", "as", "FYB", ",", "SLP-76", ",", "HS-1", ",", "Vav", ",", "SKAP1", "and", "SKAP2", "upon", "TCR", "engagement", "." ] } ]
PMC11075223	In recent years, some components of Cimicifugae Rhizoma could significantly improve dyslipidemia in mice and play a protective role.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "some", "components", "of", "Cimicifugae", "Rhizoma", "could", "significantly", "improve", "dyslipidemia", "in", "mice", "and", "play", "a", "protective", "role", "." ] } ]
PMC11365427	Arginine, a ubiquitous nutrient, is essential for the urea cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arginine", ",", "a", "ubiquitous", "nutrient", ",", "is", "essential", "for", "the", "urea", "cycle", "." ] } ]
PMC11544122	This mode of endocytosis is characterized by the presence of a short linear tyrosine-based amino acid motif on the CT or intracellular loops of the receptor, which interact with AP2 and which recruits the receptor for CME.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "mode", "of", "endocytosis", "is", "characterized", "by", "the", "presence", "of", "a", "short", "linear", "tyrosine-based", "amino", "acid", "motif", "on", "the", "CT", "or", "intracellular", "loops", "of", "the", "receptor", ",", "which", "interact", "with", "AP2", "and", "which", "recruits", "the", "receptor", "for", "CME", "." ] } ]
PMC10957991	Immunofluorescence stainings of confluent MCF10A cell cultures.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "stainings", "of", "confluent", "MCF10A", "cell", "cultures", "." ] } ]
PMC9503685	In studies of the activities of ceragenins and AMPs against intracellular bacteria, CSA-13 showed the highest activity (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "studies", "of", "the", "activities", "of", "ceragenins", "and", "AMPs", "against", "intracellular", "bacteria", ",", "CSA-13", "showed", "the", "highest", "activity", "(", "Figure", "2", ")", "." ] } ]
PMC11143482	In cancer mouse models, the effects of cancer growth on body weight can vary depending on several factors including the type of cancer, mice strain, and laboratory conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cancer", "mouse", "models", ",", "the", "effects", "of", "cancer", "growth", "on", "body", "weight", "can", "vary", "depending", "on", "several", "factors", "including", "the", "type", "of", "cancer", ",", "mice", "strain", ",", "and", "laboratory", "conditions", "." ] } ]
PMC9964635	In the HNMR spectrum, signals for N-CH3 were observed around 3.28 ppm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "HNMR", "spectrum", ",", "signals", "for", "N-CH3", "were", "observed", "around", "3.28", "ppm", "." ] } ]
PMC8557138	Shirure et al. constructed PDMS-based tumor organoids derived from colorectal cancer cell lines Caco-2 and CRC-268, breast cancer cell line MDA-MB-231, and MCF-7, and Patient-derived organoids (PDOs) derived from breast cancer patients which consisted of immune cells, ECs, fibroblasts, and cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shirure", "et", "al.", "constructed", "PDMS-based", "tumor", "organoids", "derived", "from", "colorectal", "cancer", "cell", "lines", "Caco-2", "and", "CRC-268", ",", "breast", "cancer", "cell", "line", "MDA-MB-231", ",", "and", "MCF-7", ",", "and", "Patient-derived", "organoids", "(", "PDOs", ")", "derived", "from", "breast", "cancer", "patients", "which", "consisted", "of", "immune", "cells", ",", "ECs", ",", "fibroblasts", ",", "and", "cancer", "cells", "." ] } ]
PMC9895440	For example, PD-1 blockade is thought to primarily rescue impaired CD28 co-signaling and CD28 is required for the efficacy of anti-PD1 antibodies in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "PD-1", "blockade", "is", "thought", "to", "primarily", "rescue", "impaired", "CD28", "co-signaling", "and", "CD28", "is", "required", "for", "the", "efficacy", "of", "anti-PD1", "antibodies", "in", "vivo", "." ] } ]
PMC9429973	Next, we delineated the role of the 2 functionally different domains of APEX1 in adult HSPCs, by culturing BM HSPC for 1 week in the continuous presence of different chemicals blocking the nuclease (involved in BER) or the Ref-1 function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "delineated", "the", "role", "of", "the", "2", "functionally", "different", "domains", "of", "APEX1", "in", "adult", "HSPCs", ",", "by", "culturing", "BM", "HSPC", "for", "1", "week", "in", "the", "continuous", "presence", "of", "different", "chemicals", "blocking", "the", "nuclease", "(", "involved", "in", "BER", ")", "or", "the", "Ref-1", "function", "." ] } ]

PMC9429973

Analysis of covariance (ANCOVA) models were conducted to adjust for age, sex, race, and baseline score.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "covariance", "(", "ANCOVA", ")", "models", "were", "conducted", "to", "adjust", "for", "age", ",", "sex", ",", "race", ",", "and", "baseline", "score", "." ] } ]

PMC7553912

The apparent molecular weights are indicated on the right. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apparent", "molecular", "weights", "are", "indicated", "on", "the", "right", ".", "(" ] } ]

PMC11470999

We also preliminarily elucidated the structural mechanism of PF‒CIP2A‒VHL complex formation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "preliminarily", "elucidated", "the", "structural", "mechanism", "of", "PF‒CIP2A‒VHL", "complex", "formation", "." ] } ]

PMC11708541

In the 1960s and 1970s, research began to reveal its potential therapeutic uses, particularly in neurology.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "1960s", "and", "1970s", ",", "research", "began", "to", "reveal", "its", "potential", "therapeutic", "uses", ",", "particularly", "in", "neurology", "." ] } ]

PMC11720107

The experiments showed that the Harnaś garlic cultivar significantly increased LDH release from BJ cells only at the highest concentration (1.000 mg/mL), with an increase of 16.0% compared with the control (Figure 2A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiments", "showed", "that", "the", "Harnaś", "garlic", "cultivar", "significantly", "increased", "LDH", "release", "from", "BJ", "cells", "only", "at", "the", "highest", "concentration", "(", "1.000", "mg/mL", ")", ",", "with", "an", "increase", "of", "16.0", "%", "compared", "with", "the", "control", "(", "Figure", "2A", ")", "." ] } ]

PMC10114490

This clustering also evidences the similarities between cells from different PD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "clustering", "also", "evidences", "the", "similarities", "between", "cells", "from", "different", "PD", "." ] } ]

PMC11317131

Briefly, CRISPResso2 was run in HDR mode, discard_indel_reads flag was on and quantification window coordinates were set to 10 bp upstream of each nick site.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "CRISPResso2", "was", "run", "in", "HDR", "mode", ",", "discard_indel_reads", "flag", "was", "on", "and", "quantification", "window", "coordinates", "were", "set", "to", "10", "bp", "upstream", "of", "each", "nick", "site", "." ] } ]

PMC11643491

In addition to increasing the uptake of the drug carrier by target cells, the increased energetic cost of uptake by non-target cells can minimize unwanted side effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "increasing", "the", "uptake", "of", "the", "drug", "carrier", "by", "target", "cells", ",", "the", "increased", "energetic", "cost", "of", "uptake", "by", "non-target", "cells", "can", "minimize", "unwanted", "side", "effects", "." ] } ]

PMC11718817

DNA damage in PDAC cells leads to AIM2 inflammasome activation and—via the release of high mobility group protein 1 (HMGB1)—to the expression of PD-L1 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "damage", "in", "PDAC", "cells", "leads", "to", "AIM2", "inflammasome", "activation", "and", "—", "via", "the", "release", "of", "high", "mobility", "group", "protein", "1", "(HMGB1)—to", "the", "expression", "of", "PD-L1", "." ] } ]

PMC11775197

Chiral phenoxyacetic acid analog (S)-3 acts as a partial agonist of PPARγ, blocks the cell cycle, inhibits cell proliferation, and induces apoptosis through PPAR-dependent mechanisms: upregulation of p21, and inhibition of c-Myc and cyclin D1 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chiral", "phenoxyacetic", "acid", "analog", "(S)-3", "acts", "as", "a", "partial", "agonist", "of", "PPARγ", ",", "blocks", "the", "cell", "cycle", ",", "inhibits", "cell", "proliferation", ",", "and", "induces", "apoptosis", "through", "PPAR-dependent", "mechanisms", ":", "upregulation", "of", "p21", ",", "and", "inhibition", "of", "c-Myc", "and", "cyclin", "D1", "." ] } ]

PMC10969097

Regarding clinical trials, it was not possible to assess the Risk of Bias in the clinical trials with numbers NCT05763199 and RCT20190822044579N1, as the studies are still ongoing and do not yet have results.

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PMC11638764

The colors indicate the following: red represents upregulated proteins, blue denotes downregulated proteins, and black indicates proteins with no significant change compared to the DMSO control. (

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PMC11544122

Importantly, the loss in endocytosis was rescued by the re-expression of SNX9 alone (Fig. 3c and Supplementary Fig. S1i), reinforcing the requirement for SNX9 in CXCR4 endocytosis.

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PMC11803918

Hematoxylin and eosin (H and E) staining of the tumor tissues also showed more necrosis of the tumor in hybrid exosome-treated humanized mice (Figure 8E).

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PMC11240571

Conclusions: Exosomal PD-L1 emanates from bone and soft tissue sarcoma cells and is disseminated into the circulatory system.

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PMC11438317

These data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.

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PMC11075223

In recent years, some components of Cimicifugae Rhizoma could significantly improve dyslipidemia in mice and play a protective role.

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PMC11365427

Arginine, a ubiquitous nutrient, is essential for the urea cycle.

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PMC11544122

This mode of endocytosis is characterized by the presence of a short linear tyrosine-based amino acid motif on the CT or intracellular loops of the receptor, which interact with AP2 and which recruits the receptor for CME.

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PMC10957991

Immunofluorescence stainings of confluent MCF10A cell cultures.

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PMC9503685

In studies of the activities of ceragenins and AMPs against intracellular bacteria, CSA-13 showed the highest activity (Figure 2).

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PMC11143482

In cancer mouse models, the effects of cancer growth on body weight can vary depending on several factors including the type of cancer, mice strain, and laboratory conditions.

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PMC9964635

In the HNMR spectrum, signals for N-CH3 were observed around 3.28 ppm.

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PMC8557138

Shirure et al. constructed PDMS-based tumor organoids derived from colorectal cancer cell lines Caco-2 and CRC-268, breast cancer cell line MDA-MB-231, and MCF-7, and Patient-derived organoids (PDOs) derived from breast cancer patients which consisted of immune cells, ECs, fibroblasts, and cancer cells.

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PMC9895440

For example, PD-1 blockade is thought to primarily rescue impaired CD28 co-signaling and CD28 is required for the efficacy of anti-PD1 antibodies in vivo.

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PMC9429973

Next, we delineated the role of the 2 functionally different domains of APEX1 in adult HSPCs, by culturing BM HSPC for 1 week in the continuous presence of different chemicals blocking the nuclease (involved in BER) or the Ref-1 function.

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