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OTAR3088
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PMC10823017
Cell Viability assays in Caki-1 cell line using various doses of ICA-1, BYL719 and combination therapy. (
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PMC11026382
The marginal distribution of growth rate effects is shown along each axis.
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PMC11723210
The phase values along the white line are extracted and plotted as quantitative curves in Figure 4(d1,d2), showing that the phase results recovered by the BPR method (blue curve) closely match those recovered by DHM, the gold standard (red curve).
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PMC9429973
In contrast, some genus such as Lachnoclostridium were increased in MMdx (Fig. 1C).
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PMC11190538
It exhibits an average fluorescence emission at approximately 650 nm and a single absorption peak in the visible spectrum, specifically between 615 and 620 nm.
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PMC10530622
There is clear long-standing evidence from numerous studies that HIF-1α and AhR activities are interdependent .
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PMC9429973
Limited data exists on molecular predictors of response and survival.
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PMC10571053
Functional assays were also used to confirm transporter activity.
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PMC10452486
Their presence is more easily accounted for, however, by the dissociation of B2m from the B2m-associated HCs once they reach the cell surface.
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PMC11741577
As such, FSL-1-treated HMC-1 CM could still enhance HaCaT cell migration although tryptase levels decreased.
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PMC11078693
Incubate the cells in an orbital shaker at 37°C and 100 rpm for 20 min.
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PMC11674834
In the current study, we used this model to investigate bioactivation, mutagenicity, DNA damage, and oxidative stress following exposure to 3,4-DMA.
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PMC9429973
CYT-338 pharmacokinetics in mice was evaluated following a single intravenous injection.
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PMC11365983
Expression and phosphorylation of Sufu, a core Hh pathway inhibitor, is also increased with Foxc1 mutation. [
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PMC9429973
More specifically, three comorbidities independently increased the FR: chronic cardiopathy (HR 1.653; 95%CI 1.017-2.687), chronic pulmonary disease (HR 1.847; 95% CI 1.097-3.109), and diabetes mellitus (HR 1.712; 95% CI 1.006-2.914).
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PMC2614416
This work is the first report on the use of proteomics, Gene Ontology and Directed Acyclic Graph representations to detect and quantify the repression of oxidoreductase enzymes in hepatoma.
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PMC9847912
CEMss cells were seeded into EDGE 2.0 96-well plates at 2.3 × 10 cells per well in 150 μl per well of complete IMDM containing 20 μg/ml DEAE-dextran.
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PMC9429973
Induction death was noted in 7% and post-induction death was noted in 14%.
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PMC11794588
This article attempts to contribute to the scientific developments in the Solanaceae family’s anti-cancer field.
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PMC11683130
Next, we summarized the pathogenic role of serpins in psoriasis.
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PMC11389534
UFL1 deficiency effectively suppresses the activation of IRF3 and NF‐κB signalling pathways in macrophages upon HSV‐1 infection.
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PMC10858941
However, we have reported recently that, in fact, induction of GBM cell apoptosis by NNC is mainly due to calcium mobilisation and activation of ER stress cascade .
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PMC11770130
By pulling down CerS2 with the Flag tag and performing immunoblot with a pan phosphor-Ser/Thr antibody, we identified that NTS suppressed the phosphorylation of CerS2 in the primary adipocytes (Fig. 3c).
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PMC6799808
P < 0.05 was considered to indicate significance.
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PMC5874706
After 24 h, the medium was replaced by fresh medium containing either a working solution containing THN7 alone (1 μL of THN7 stock solution added to 99 μL medium) or a working solution of THN7-loaded nanoparticles (1 μL of stock solution of THN7-loaded nanoparticles added to 99 μL medium).
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PMC11787381
The mice were allowed to freely explore the MWM for a maximum of 60 s per trial.
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PMC11543853
Images of 2035 particles of rhinovirus 2 were manually boxed from micrographs of cells 30 and 40 min post-infection using cryolo_boxmanager from the software Cryolo 1.5.4.
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PMC10847511
Although various research has been conducted using the above cancer cell line databases, there have been no reports to clarify the association between HRD status and the sensitivity to PARP inhibitors or platinum drugs.
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PMC11747467
We found that the chromosomal locus containing ERBB2 exhibited a lower G-score in basal bladder cancer and a higher G-score in luminal bladder cancer ( Supplementary Figure S7D ).
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PMC11361748
These findings show that endogenous PKCα activity mediates neutrophil infiltration in a K17-dependent manner in mouse skin and in human keratinocytes treated with TPA. (
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PMC9429973
Methods: We retrospectively analyzed a cohort of 167 patients with myelofibrosis treated in 6 Croatian hematology centers in period from 2004-2021.
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PMC11721587
For deSUMOylation assay, yeast C-terminal 204 amino acid fragment containing Ulp1 catalytic domain (Ulp1-C204) and its C580S variant (enzymatically dead form) was subclone into pGEX 4 T-1 vector.
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PMC11703896
Rapamycin can act on multiple receptors on the cancer cells and induce enhanced antitumor activity.
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PMC11412721
Statistical analysis with Mantel–Cox test. (
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PMC11711127
In this section we will also discuss other immune cells involved in the control of T cell resistance to activation.
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PMC11252033
The IC50 drug concentration resulting in a 50% reduction in the net protein content (as measured by SRB staining) in drug treated cells as compared to untreated control cells was determined.
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PMC11753435
Image analysis was performed with ImageJ. Antibodies used and the corresponding dilutions are as follows: rat-anti-HA (1:500; Millipore, 11867423001), goat-anti-rat 488 (1:500; Invitrogen, A11006), and streptavidin 568 conjugate (1:500; Invitrogen, S11226).
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PMC11742290
In CRC, LGR5-targeting CAR-T cell therapy for human metastatic CRC had minimal off-target effects and are being evaluated in human clinical trials (Clinical Trials ID.
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PMC7369657
After incubation with CQDs for 24, 48, and 72 h, the medium was replaced with 200 μl culture medium with 20 μl NR solution and incubated for another 2 h. Then, 200 μl of cell lysis solution was added to extract the dye.
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PMC9429973
The figure presents the weighted (or MAIC-adjusted) and unweighted (or unadjusted) treatment effect comparisons along with their 95% CI for SVR35 and corresponding ESS at Wk 24.
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PMC7709199
Cube-shaped crystals of DSCAMIg7–Ig9 obtained by HEK293 GlycoDelete expression appeared within 1–3 days in 0.2 M calcium acetate, 10%(w/v) PEG 8000, 0.1 M HEPES pH 7.5 (condition H8 from The PEGs II Suite, Qiagen).
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PMC7039683
We identified the top-scoring 0.1% bin of tiles (28,595 tiles) and examined their overlap with active enhancers, defined by ChIP-seq with antibodies to various chromatin-marks, in 125 cell/tissue types evaluated by the Roadmap Epigenomics project (Kundaje et al., 2015).
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PMC11389534
B‐cells stand as pivotal players in the generation of specific antibodies.
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PMC11411131
Schematic diagrams of selenoprotein synthesis.
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PMC11770130
In order to obtain clean data, reads containing adapters were removed and low-quality bases were trimmed with Trimmomatic (24) in this step.
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PMC11082662
This suggests that SMPDL3B may serve as a downstream target of ACER2, holding importance in the progression of ovarian cancer.
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PMC11283030
ACLY and p-ACLY expression was assessed with IHC on tissue microarray.
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PMC10213199
The RNA-seq results showed that the traditional Chinese medicine JYL has longevity and anti-aging effects, indicating that further investigation is required.
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PMC10728200
E GIST-T1 and 882 cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h, and RNA expression of STUB1 were measured.
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PMC11621493
C, D) Total LPC and LPE levels calculated based on the sum of signals from all detected subspecies. (
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PMC9429973
ALT and/or AST elevations were the most common AEs leading to treatment discontinuations (15).
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PMC11766309
Gene alteration and structural variation of YKT6: (A) landscape of genomic alterations of YKT6 across cancers via the cBioPortal database; (B) correlation between YKT6 gene expression and copy number across cancers; (C) correlation between YKT6 mRNA expression and copy number alterations was not significant only in KICH; (D) Pearson’s correlation between YKT6 expression and methylation of the YKT6 promoter in each tumor; (E) correlation between YKT6 mRNA expression and methylation was significant only in THCA.
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PMC9429973
O. Albanyan, D. Kalos, J. Kim, R. Faramand, H. Elmariah, A. Mishra, T. Nishihori, L. Perez, M. Nieder, J. Pidala, N. Bejnayan Department of Blood and Marrow Transplantation – Cellular Immunotherapy; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, United States of America Background: Allogenic hematopoietic cell transplant (allo-HCT) is the only curative treatment option for many adults with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
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PMC6643347
Assessment of cell viability Cell viability was determined by the MTT assay based on the ability of live cells to convert the readily soluble yellow 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) into insoluble purple intracellular crystals of MTT-formazan.
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PMC8303372
In this work we used core-shell NPs made of PolyD-L-lactide-co-glycolide (PLGA) coated with chitosan (CS), prepared through an osmosis-based methodology, to efficiently entrap GA.
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PMC9429973
F. Talbi, D. Djamel, D. djameli hematology, military hospital, algiers; hematology, PTS Boufarik, Blida; hematology, pts boufarik, algeria, Algeria Background: The overall number of red blood cell (RBC) units distributed to hospitals throughout the world has significantly decreased lately.
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PMC10093184
Statistical analyses (unpaired t-test with Welch’s correction) were performed with GraphPad Prism 8.4.3 (GraphPad Software, San Diego, CA, USA).
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PMC11746948
The detailed mass spectrometry data is shown in Supplementary Data 2.
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PMC10024132
Additionally, CAR-T cells have the potential for lifelong persistence, while long-term persistence of T cell activation is not achievable with blinatumomab.
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PMC8592717
PCA promoted antioxidant activities, suppressed lipid peroxidation, and decreased the serum corticosterone level in Swiss albino mice with ARS.
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PMC11707832
Several investigations have explored the association between MAN2B1 and bacterial infections.
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PMC9429973
From baseline to last available on-treatment value, mean Hb improved to >12 g/dL, a mean (SD) change from baseline of 3.6 (2.19) g/dL (n=22); the mean (SD) Hb level at 9-week follow-up was 10.1 (1.6) g/dL (n=20), a decrease of 2.28 (1.8) g/dL from the last available on-treatment value (Figure 1).
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PMC9429973
RNA was extracted and total RNA libraries were created using enzymatic ribosomal RNA removal.
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PMC10142392
From a rheological point of view, hydrogels exhibit viscoelastic behavior and partially purely elastic behavior .
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PMC6643347
Of particular importance to the pathogenesis of the HIV infection is the ability of macrophages to serve as a viral reservoir that is resistant to antiretroviral therapies and cannot be recognized by the cytotoxic lymphocytes of the immune system (due to the absence of active viral reproduction and synthesis of virus-specific proteins, respectively).
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PMC11449273
H1299 cells transfectants were seeded in triplicates at 7.5x10 cells in 35 mm dishes containing 0.35% top agar and 0.6% base agar and grew for two weeks.
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PMC11543935
The raw data was reconstructed using a Br40 convolution kernel.
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PMC9429973
FeO in PK deficiency is clinically underappreciated and may cause long-term organ damage and impact growth in children and adults.
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PMC11531735
These mice harbor the human HER2 gene under the control of an MMTV promoter.
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PMC6487404
Apparent permeability coefficient (P app ) of REG, across everted gut sacs at various drug concentrations (Mean ± SD, n = 3) P < 0.01: significant difference when compared to the lower REG lower concentrations.
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PMC10810426
LAMIN B1 was used to detect nuclear and TUBULIN to detect cytoplasmic fractions.
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PMC9429973
Patients will receive two doses of ANX005 on Days 1 and 8.
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PMC9429973
Assessment of the effect of comorbidity: patients with 6 or more comorbidity scores according to Charlson have 2.2 times greater risk of death; the presence of cardiovascular diseases increases the risk of death of the patient by 2.3 times.
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PMC9100622
All PDX tumors exhibited a type 1 fusion transcript of EWSR1-FLI1 (EWSR1 ex7/FLI1 ex6 fusion) except for IC-pPDX-164, showing EWSR1-FEV fusion.
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PMC11759543
However, it showed an antagonistic effect when a higher dose of doxorubicin was used.
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PMC9429973
Monthly DT within 6 months after DA DISC is presented in Fig C. Based on the final result of 11.4% TFR2 rate, we conclude that 12 months’ DA re-therapy could not improve TFR2 rate significantly.
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PMC11228511
High-magnification images of the boxed regions are shown on the right (white). (
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PMC11420784
Thus, our results uncover a critical role for PldA to inhibit autophagic flux, favoring UPEC escapes from lysosome exocytosis, thereby contributing to acute urinary tract infection.
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PMC11472639
All participants were ≥18-years of age and were diagnosed as having SMM in-line with the 2014 International Myeloma Working Group (IMWG) criteria (Rajkumar et al., 2014).
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PMC10376064
In addition, DMF has been demonstrated to form glutathione conjugates , and many glutathione conjugates were demonstrated to be substrates of ABCC1 .
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PMC9429973
were evaluated.
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PMC10743717
An interface between the layers does not disappear after the addition of 1% Me2SO to the assay system and being vortexed at high speed for 3 min and then incubated at room temperature (25 °C) for 72 h (see Tubes 3 and 3′ in Figure 8).
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PMC9429973
To date, segmentation on 303 exams from different centers showed very few false positive and some false negatives highlighting the need to take into account different technical characteristics (various equipment in different centers) Image: Summary/Conclusion: SCD is a rare systemic disorder with extreme phenotypic variability.
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PMC11569208
Cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM; HyClone cat.10–013) supplemented with 1% (v/v) penicillin-streptomycin (Gibco), 30mM HEPES buffer, and 10% (v/v) serum composed of 3-parts HyClone newborn calf serum (Thermo Fisher, cat.
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PMC8316344
E Cell proliferation was evaluated by a CCK-8-based method in control cells and SK-Hep1 cells with or without TFRC knockout or βTrCP overexpression.
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PMC11798926
This could be due to a defect in protein folding.
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PMC11576293
Additionally, these compounds were potent inhibitors of cancer cell growth, with GI50 values of 22 and 24 nM, respectively.
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PMC11612794
In this study, we demonstrated that CENP-T binds to Mis12C mainly via two interaction regions (binding regions 1 and 2), and each of them is important for Mis12C binding.
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PMC10048572
Grown cultures were transferred to centrifuge tubes and sedimented for 5 min at 200 g. DNA was isolated from the cell pellet using proteinase K digestion.
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PMC11297139
The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcome.
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PMC11756907
Therefore, the conducted studies showed that the GO-2-ME hybrid produces, on average, the greatest reduction in the viability of the 143B osteosarcoma cells at a dilution of 1:10.
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PMC11711127
Randomised recombination events that generate TCRs represent a double-edged sword in immunity: whilst they endow the immune response with remarkable flexibility and robustness, they also potentiate debilitating autoimmune diseases.
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PMC11590870
The antioxidant activity of MOP and MOPH, as assessed by the CAA assay, was determined by measuring the prevention of the oxidation of 2′,7′-dichlorofluorescin diacetate to 2′,7′-dichlorofluorescin through the quenching of the peroxyl radical (RO2·).
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PMC11265931
These nanoparticles play an important role in the transmission of hereditary materials through intracellular communication and in multiple biological events, such as the regulation of responses in the immune system (Von Schulze and Deng, 2020).
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PMC9429973
Hypertension and renal failure were among the most prominent comorbidities.
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PMC11637284
The absence of the kDNA was determined by eye.
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PMC9429973
None had a previous history of thrombosis.
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PMC10926885
Locus of interest; (B) Structure; (C) Related genes. *
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PMC9429973
Aims: A systematic review of the published literature was conducted to investigate the rate of MGUS progression to support clinical practice.
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PMC11615828
The paralyzed worms gradually restored their movement to the basal level when the light was ceased.
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