Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC2118063
Transcripts for BCL6 and AICDA were highest in CB and decreased in memory and plasma cells.
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PMC8750422
We found that LPA treatment significantly increased AKT and eNOS phosphorylation and GPR87 overexpression further increased the effect of LPA treatment.
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PMC10093184
Excessive ethanol was removed from the upper surface of the insert using a dry cotton swab and inserts were air-dried.
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PMC9429973
There was weak evidence that a history of grade 3-4 acute graft-versus-host disease (aGvHD) increased the risk of sPGF (p=.092).
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PMC10999934
FBXO2-dominated interaction network.
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PMC9910796
In the first location, the ER-derived inner viral envelope acts as a docking platform for the multiple interactions required for the assembly of the external and internal viral layers .
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PMC11536589
Representative images of KI67 detected in the removed tumor tissues by immunohistochemistry staining of four groups.
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PMC9429973
And these facts are evident mainly in the first phase of the mild disease.
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PMC8382973
The free primers and primer dimer species in the amplified products were purified using AmPure XP beads.
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PMC11805741
The UCSF Chimera analysis of the BCL-2 protein complex with the ligand zeaxanthin revealed key structural and interaction insights.
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PMC11599565
These cells, such as Purkinje cells, demonstrate the capacity of mesodermal-derived cells to adopt neural cell fates.
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PMC10538569
GPI-scFv X5-transduced TZM.bl cells are resistant to iDC- or mDC-mediated trans-infection of HIV-1. (
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PMC9812014
Western blot also revealed that the nsP3 and E2 proteins of CHIKV were dose-dependently inhibited by this alkaloid.
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PMC5415764
The cellular accumulation of Rho 123 in the various treatment groups was observed using an Incell 2000 Analyzer (GE, Buckinghamshire, UK).
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PMC11676674
Once the data were obtained in the form of a spectrum, the most abundant metabolites corresponding to the main peaks were putatively identified based on different parameters: the accurate mass (from the m/z ratio of the ions), the retention time (RT), and the fragmentation pattern (ms/ms) of the main detected signals obtained from the FAST-DDA run method, consulting the scientific literature, public databases, and an in silico proprietary library of plant compounds.
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PMC11765243
Previous data using gene inactivation, the expression of kinase-dead isoforms, and/or isoform-specific inhibitors showed that both class IA p110δ and class IB p110γ PI3K subunits were essential to T cell differentiation in the thymus during both pre-TCR- and TCR-dependent steps .
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PMC11740207
Over time, with sufficient lifespan allowing for the accumulation of leukemogenic changes, these events can also occur in LT-HSCs (as well in earlier progenitor stages of lifetime blood development)—initiating AML.
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PMC10969097
Over the years, several species of mushrooms have already been thoroughly characterised, resulting in the successful identification and isolation of their bioactive compounds .
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PMC11499955
Among the described methods used to quantify the abundance of protein receptors in cells and in biopsy tissues, cyclic immunofluorescence appears to be one of the most promising.
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PMC10976516
Study is ongoing.
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PMC9429973
Patients with rearrangements of CRLF2 (n=52) and ZNF384 (n=37) had similar outcomes to the cohort overall.
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PMC11476222
In this study, we optimized the extraction method to obtain gangliosides and other sphingolipids from cell lines more effectively.
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PMC10631132
We hypothesize, that since the MB differentiation process gave rise to ontogenetically earlier HPCs compared to the EB method, MB cells might not have reached the OC stage in the same differentiation time span as compared to cells differentiated using the EB protocol and might have remained in earlier stages or side trajectories such as macrophages or dendritic cells.
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PMC10047551
An additional analysis of the 3′ end of the PD-L1 CpG island and its associated shore region further supported the fact that there was a gain in targeted PD-L1 methylation due to the presence of the Sp sgRNA pool and that this methylation spread into the otherwise unmethylated CpG island (Figure 4D and Figure S5C).
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PMC8041314
In short, calcein AM and pheophorbide A are ABC transporter substrates that diffuse into the cells and get effluxed by the respective ABC transporter.
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PMC9429973
The use of myeloablative conditioning (MAC) (86% vs 57% in reduced intensity (RIC); p-value 0.04) and Methotrexate on the immunosuppression regimen (100%; p-value <0.001) were the two factors with more impact on its appearance.
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PMC10898159
KIT mutations is an early step for the development of GIST from ICC, meaning KIT necessitates the survival of GIST cells .
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PMC11204465
Seven new compounds, including O-ethylsterigmatocystin (42), O-propylsterigmatocystin (43), O-butylsterigmatocystin (44), O-penlylsterigmatocystin (45), O-propenylsterigmatocystin (46), O-acethlsterigmatocystin (47), O-benzoylsterigmatocystin (48), were isolated from Aspergillus sp. .
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PMC10213179
Based on these observations, EphA2 is a promising therapeutic target for cancer treatment.
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PMC9429973
Duration of DARA use was defined as the time interval between first initiation and discontinuation of DARA spanning multiple LOTs as a time-to-event outcome using Kaplan-Meier method.
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PMC8992508
Compounds 78, 79, and 80 were found to be stimulators of basal ATPase, while compound 82 was found to be an ATPase inhibitor.
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PMC11576293
Additionally, running two different 2D NMR experiments on the same intermediate (8) revealed the following characteristics: The HMQC experiment showed a cross peak of C4-H and C5-H, in addition to the disappearance of signals corresponding to pyrimidine ring N1-H and N3-H (as shown in Figure 4).
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PMC11437637
We found that in patients with endometrioid carcinoma, the Treg/CD4+ T ratio was markedly greater than that in people with non-endometrioid carcinoma, which led to the hypothesis that patients with estrogen-dependent endometrioid adenocarcinoma have worse immune suppression.
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PMC11746942
8Proposed model of S1PR3-mediated keratinocyte hyperproliferation in psoriasis.
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PMC11365427
Consequently, our research supports the findings that phenylalanine directly interacts with the VAPB protein.
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PMC9429973
E. Nora, E. mahtat, S. jennan, H. elmaaroufi, K. doghmi hematology, military hospital RABAT MOROCCO, rabat, Morocco Background: Primary gastrointestinal lymphoma represents non-Hodgkin’s lymphoma(NHL) is the most common extra-nodal lymphoma.
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PMC5833712
Triplicate reactions were performed for each marker and the melting curves were constructed using Dissociation Curves Software (Applied Biosystems, CA, USA), to ensure that only a single product was amplified.
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PMC11095939
This hypothesis was supported by proteasome inhibition with the proteasome inhibitor MG132, which attenuated the reduction of Mecp2 in quiescent cells after SR (Figure 5—figure supplement 1A).
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PMC11562028
To preliminarily investigate the molecular mechanism of the cell cycle arrest and apoptosis caused by Re-CDs administration, the changes of the reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and Ca concentration inside the A498 cells have been detected (Fig. 4).
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PMC9429973
Bulk RNAseq analysis demonstrated that following nuclease and Ref-1 chemical inhibitions, immune response and interferon signaling were downregulated, whereas oxidative stress response genes were upregulated.
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PMC9429973
Previously assessed institutional review revealed gram negative bacteria to be the most common microorganisms, and leading cause of febrile neutropenia.
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PMC11684269
The utilization of JHU083, a glutamine antagonist, reversed the T cell metabolic alterations induced by AKI and simultaneously inhibited the differentiation of T cells, thus alleviating kidney damage ( Table 1 ) (126).
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PMC9688728
This typical hallmark of cancer cells reflects their altered energy metabolism.
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PMC11747467
However, this combination strategy still needs to be validated through further clinical trials, including assessments of anticancer efficacy and safety.
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PMC11767793
Nanoparticle comprehensive characterization is a labor-intensive process, requiring specialized equipment and expertise that is not widely available in laboratories that specialize in biological testing.
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PMC9429973
Methods: Patients with newly diagnosed stage III or IV cHL who were aged 5 to <18 years were treated with A+AVD on days 1 and 15 of 28-day cycles, for a maximum of 6 cycles.
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PMC11597291
Thus, the nCGO-PEG(10 kDa)/PCT was selected for cellular studies.
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PMC11401358
The orange line shows a typical β-sheet structure of SF, and the blue line depicts a similar random coil secondary structure of SF after treatment with H2O2. (
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PMC6267596
DH/DE-DLBCL cell lines U2932, U2904 and OCI-Ly18 were obtained from Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ).
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PMC10196713
The libraries were amplified using an Ion OneTouch 2 System (Thermo Fisher Scientific, Inc.).
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PMC2944824
A number of parameters were examined to determine whether the changes in viability were due to effects on apoptosis.
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PMC11464609
All samples were sequenced (i) with and (ii) without viral enrichment (i.e., conventional metagenomics) on a NextSeq device, respectively.
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PMC3675084
Isocratic elution with acetonitrile (0.5% formic acid): water (0.5% formic acid) (70∶30, v/v) was delivered at a flow rate of 0.2 mL/min.
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PMC11678368
Computational investigations were carried out using Gaussian 16 within the density functional theory (DFT) framework, employing the ωB97X-D long-range corrected hybrid functional with dispersion correction .
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PMC11574029
To identify the potential target genes through which NOTCH3 promotes malignant progression in BLCA, we analyzed the expression of the top 20 downregulated differential genes (Supplementary Table S4) using TCGA databases, as well as their association with the prognosis of BLCA patients.
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PMC10589262
Schematic representation of novel GIST tumorigenesis mechanisms via the Golgi-localized MT-KIT-mediated oncogenic signaling and constant activation of pro-survival ATF6 dependent UPR signaling.
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PMC8973725
However, the function and mechanisms of action of ZNF677 in ccRCC cells remain elusive.
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PMC11754784
In contrast, commercialized monoclonal antibodies B6H12 caused enhanced hemolysis in lower concentration range (from 0 nM to 85 nM), but caused weakened hemolysis in higher concentration range (from 85 nM to 680 nM) (Fig. 6b and Supplementary Fig. 34).
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PMC9429973
Aims: To identify vulnerabilities in AML beyond the MLL-AF9 oncofusion gene we determined cell fate determining transcription factors pertinent to the two clinically and biologically different subgroups.
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PMC7215832
For this purpose, we used the non-small cell lung cancer (NSCLC) cell lines SW1573 and A549, each known to have specific aberration in certain TSGs.
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PMC9429973
Cohort A includes patients with newly diagnosed TP53-mutated AML.
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PMC9429973
Summary/Conclusion: Collectively, this preclinical study supports the concept of triggering cytolytic T cell activity in CLL with bispecific antibody combination immunotherapy that could help overcome T cell exhaustion and the immunosuppressive TME.
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PMC11307990
This strategy may enhance release from the extracellular environment, but it cannot achieve effective accumulation on the cells.
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PMC11640247
(bin 1) (-) vs. WT, p = 0.82; (-) vs. R66W, p < 0.001; WT vs. R66W, p < 0.001. (
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PMC9429973
Results: In this study, we found that reduced RYBP expression is observed in MDS patients and associated with high AML transformation.
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PMC9429973
Therefore, strategies to stop lifelong TKI use should be prioritized to reduce adverse events.
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PMC11694625
Since nitrosamine impurities were detected in pharmaceuticals in 2018, people have become aware of these impurities in raw materials.
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PMC10777969
We observed a striking difference between FCP23 and FCP26 (Figure 4A–C).
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PMC10882807
Fig. 3Hsa_circ_0005397 affects migration and invasion in HCC cells. (
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PMC9516401
Herein, we assessed the efficacy of five herbal extracts derived from P. vulgaris, C. colocynthis, P. oleracea, A. cepa, and C. verum on the activity and expression of IDE in Caco-2 cells.
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PMC11281366
We also tested, in this system, two different CD59 3′ UTR fragments (A and B) (Figure 4C), each containing one of the two single individual sites targeted by miRNA-26a and found that both sites are functional and independent (Figure 4D).
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PMC11401358
ATR-FTIR characterization of (GAGSGA)2. (
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PMC11519788
To uncover the cytokines/chemokines in the CM that may mediate the effect of SPOP on macrophage migration, we conducted an RT-qPCR array of 48 genes implicated in cell-cell crosstalk within the TME 11, 27-28.
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PMC9429973
A diagnosis of t-AML was present in 30% (22/74) patients.
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PMC11397654
Therefore, calixarenes functionalised with trifluoromethylanilines have high antiproliferative activity against certain human cancerous cell lines; however, their highest activity was against HeLa and MCF-7 cells, depending on the structure of the compound, and none of the compounds were active against Hep-2.
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PMC11394730
Piperine is a bioavailability enhancer for several chemotherapeutic agents, such as resveratrol and curcumin.
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PMC11792888
Figure 2.
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PMC10852540
RA plays an important anti-proliferative role, which is also associated with a decrease in EGFR expression.
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PMC11618052
We docked compounds 8f, 8g, 8h, 8j, and 8l with EGFR kinase to determine the binding affinity of derivatives with the best in vitro activity against EGFR, and Table 5 shows their docking scores.
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PMC11666785
Subsequently, the parameters are computed for the paired molecules.
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PMC9429973
Hematologic response to PEG and CTRL was categorized as complete, good, partial, or minor at baseline and at Week 26 using the number of packed red blood cells transfusions needed in the last 6 months and Hb level at the specified timepoints (revised categorization criteria per Debureaux PE, et al. Bone Marrow Transplant.
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PMC11228511
In Zmpste24 cells without a nuclear bleb (n = 187 cells), only 8% had a NM rupture (Fig. 7B).
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PMC10197932
Furthermore, CD137 has protective roles in preventing apoptosis in T cells as well as cell memory and effector differentiation changes the mitochondrial metabolism to increase T-cell respiratory capacities.
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PMC11665584
The transcription factor PITX1 is highly expressed in the oral epithelium but is undetectable in cutaneous keratinocytes.
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PMC11574029
These results suggest a regulatory role of NOTCH3 on the SPP1-PI3K/AKT axis.
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PMC9429973
However, the response caused by AB0 incompatibly is modest most likely due to the expression of AB0 blood type antigen in several organs.
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PMC10669966
No. SK-4105, Vector Laboratories, Burlingame, CA, USA).
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PMC11407042
The presence of antibiotics in the co-culture medium can slow down the growth of P. aeruginosa strains, leading to a reduced release level of LDH and, consequently, a lower detected absorbance than expected.
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PMC11762280
We further validated the occurrence of PANoptosis indicators in human skin with chronic UV injury.
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PMC9681981
The contact of type D cells with Coca-2 cells did not stimulate an increase in cpa gene expression.
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PMC11534377
Subsequently, the RNA concentration was quantified utilizing a Nanodrop-ND-2000 spectrophotometer, and RNA quality was assessed through Bioanalyzer 2100 (Agilent Technologies).
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PMC9429973
Methods: We conducted a survey within the Italian Campus ALL group about pregnancies in adult ALL survivors.
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PMC10808409
Data are given as mean ± SD (n = 3).
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PMC11095939
There is an urgent need to synthesize DNA, proteins, and lipids required for the generation of daughter cells in resting cells reentering the cell cycle (Coller, 2019).
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PMC10582049
Context-dependent involvement of CAFs in determination of tumor progression can be used for tumor behavior prediction.
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PMC11607321
We also aim to address the complex challenge of data missing not at random (MNAR), a scenario commonly encountered in omics datasets, by adapting VAE architectures to more accurately identify and handle MNAR scenarios.
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PMC11770130
In the current study, we found that the depletion of Ntsr2 in white adipocytes upregulated food intake, while the local treatment of NTS suppressed food intake.
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PMC11546117
The ionization of analytes was operated at positive mode, except for CDF at negative mode.
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PMC11683240
While humans have only one gene that codes α1AT, SerpinA1, mice have up to six paralogs.
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PMC9429973
Endothelial microvascular function was quantified during post-ischaemic reactive hyperaemia (PIRH).
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