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BioData-CellLine_annotated

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PMC11394112
Here, we employed two different subtypes of DLBCL cells, U2932 (ABC) and VAL (GCB), and intravenously injected them into three strains of immunodeficient mice, NOD-scid-IL2rgnull (NSG) mice expressing human IL6 (NSG-IL6), IL3/CSF2/KITLG (NSG-SGM3), or NSG mice expressing all four human cytokines (NSG-IL6/SGM3), to establish a pipeline for the rapid and reliable generation of in vivo DLBCL models.
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PMC11513011
In vivo, intratumoral administration of DIB was shown to significantly inhibit tumor growth in both non-invasive and invasive bladder cell lines without significant differences in body weight and physical appearance between control and DIB treated groups.
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PMC11228511
In Zmpste24 cells with a nuclear bleb (n = 110 cells), 61.2% had an abnormal lamin A meshwork; in cells without a bleb (n = 198 cells), 2.5% had an abnormal lamin A meshwork (Fig. 7D).
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PMC11721587
We found that both Fu and Ulk3 contain two inverted phosphorylation-dependent SUMOylation motifs (IPS1/2).
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PMC11634794
Notably, lower levels of LAMP1 expression were observed in tumors with higher stages and grades, and the expression levels were even lower in males and whites; however, its expression level remained independent of M and N stages, age, and tumor location within the left or right kidney according to Supplementary Figures S1F–I findings.
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PMC11706491
On the other hand, the behavior of the FLCCR strain under conditions where cells deviate from normal cell cycle progression remains unclear.
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PMC9429973
Recent publications showed erythropoietin (EPO) as a novel inducer of FGF23 production.
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PMC9429973
All 31 subjects completed the study.
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PMC11486946
Each cell was recognized by its nucleus.
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PMC11026382
f Heatmaps of simulated growth rates (top row) and epistasis (bottom row) computed over a range of DHFR kinetic parameters in four TYMS backgrounds.
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PMC11518994
Either an hypomorphic PAX5 missense variant or a PAX5 haploinsufficiency, as a consequence of frameshift variant, might be tolerated in the germline, possibly with different latency, but a complete deregulation of PAX5 is required for full-blown leukemogenesis.
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PMC11790971
Looking forward, we envision that the versatility of the proposed methodologies extends far beyond biopharmaceutical cell line selection, promising to reshape our understanding of cellular biology and accelerate advancements across a wide range of scientific disciplines.
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PMC11025866
Data shown are the average and standard deviation of three technical replicates with three biological replicates showing the same pattern.
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PMC11739670
However, the biophysical parameters governing human CD8αβ interactions with classical MHC class I (MHCI) and unconventional MHC‐like molecules have not been determined.
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PMC11394730
The synergistic effects of EGCG with other compounds, such as ginseng derivatives, further underscore its role in cancer chemoprevention.
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PMC9454178
Mice were treated with THZ1 (10 mg/kg) or PBS intraperitoneally every three days.
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PMC11721587
Membraneless organelles or biomolecular condensates have been implicated in many cellular processes (39–41).
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PMC11757230
Representative histograms and the proportions of cells in the G0/G1, S, and G2/M phases under different culture conditions are shown for (a) CLC, (b) CLK, (c) Ema, (d) CL-1, (e) UL-1, and (f) GL-1.
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PMC11705630
Intriguingly, a recent study identified GLDC as host susceptibility gene to severe influenza 31.
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PMC11725127
The IC50 value of GA for inhibiting USP2 was determined to be 1.8 μmol/L. Data are mean ± SD (n = 3), P-values were analyzed by two-way ANOVA (F).
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PMC6337547
The pathophysiological mechanism of myocardial/cerebral ischemia-reperfusion injury is complex, and phenolic acids act against it through mechanisms such as regulation of active oxygen metabolism, inhibition of inflammatory reaction, apoptosis, and calcium overload .
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PMC11267036
In recent years, TCM has been widely applied in cancer treatment in China.
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PMC11366496
Cell growth was assessed employing colony formation assay in various treatment cohorts and histogram quantification (panels). (
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PMC11697065
No. 2060–02) were added to each sample.
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PMC11607764
Indeed, in our settings, we can see the potential impact of “spliceosome”, “cell cycle”, “p53 signaling pathway”, and RNA metabolism in the occurrence and development of cancers (Figure 6(E) and (F)).
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PMC9019892
This experiment was carried out once. (
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PMC9429973
Thus, it might act as a promising target to restore anti-lymphoma immune responses.
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PMC11612794
The mean fluorescence signal intensities at kinetochores in each cell were subtracted by the mean background signal intensity in the non-kinetochore region.
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PMC10243817
Fixed and permeabilized cells were incubated with a primary Ab against p-SMAD2 (1:200; catalog 18338, Cell Signaling Technology) overnight at 4°C, followed by incubation with fluorophore-conjugated secondary Abs listed in Supplemental Table 3.
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PMC9693627
The latest published data based on mitochondrial ribosome profiling have shown that translation initiation of COIII in human mitochondria can be carried out from completely processed leaderless and unprocessed mRNA with prolonged 5′-UTR .
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PMC10900886
We showed that EV-D68 can infect and replicate in specific immune cells, that is, B cells and dendritic cells (DCs), and that virus could be transferred from DCs to B cells.
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PMC11612794
Based on these results, phosphorylation of both Dsn1 and CENP-T is important for timely and stable CENP-T-Mis12C interaction during mitosis, and this regulatory mechanism is critical for mitotic progression and proliferation of CENP-C cells.
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PMC11257988
Experimental evidence suggests that BI-3406 reduces the formation of GTP-loaded KRAS and restricts the growth of most tumor cells driven by KRAS variants at positions G12 and G13.
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PMC8662250
Also, we observed an overrelease of proinflammatory/propyroptotic mediators such as IL‐1β and IL‐18 by challenged epithelial cells.
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PMC7039683
Similarly, the zebrafish orthologs of such genes are expressed, on average, at higher levels in GFP-positive versus GFP-negative cells described above (Wilcoxon rank sum test, p-value=8.371e-06).
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PMC11754436
Representative photo of nude mouse tumors. (
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PMC10380508
These results indicate that high expression of PAX2 in KIRC patients and high expression of PAX8 in KICH patients are associated with better prognosis (Supplementary Figures S5 and S6).
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PMC11462673
Simultaneously, we verified that knockdown of LDB1 induces cell cycle arrest in the G0/G1 phase ( Fig. S2A, B).
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PMC11487720
Then, these cells were cultured at 4, 10, 22, and 37 °C, respectively, for indicated times (Fig. 2B-J).
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PMC9027909
Our results demonstrated that B3STA may change miRNA expression, which are involved in the gut barrier integrity, and downregulates claudin-7, which is known as sealing factor.
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PMC11720107
We also evaluated the expression of selected genes and proteins associated with cell metabolism, free radical neutralisation, and the processes of autophagy and apoptosis.
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PMC10380508
Doberstein et al. found that PAX2 binds to the A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) promoter and that inhibiting PAX2 expression significantly reduces the expression levels of ADAM10 protein in RCC cells .
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PMC8557138
The authors revealed that the transparent, elastic pH-responsive random coil conformation supports cell survival but later its transition to the β-sheet conformation induces apoptosis in vitro and inhibits angiogenesis and tumor growth in vivo (Yan et al. 2016).
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PMC11395280
These activating mutations of Notch1 have been observed in ~73% of T-ALL relapse patients as well.
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PMC7709199
DSCAMIg7–Ig9 obtained from wild-type HEK293T cells crystallized within seven days at 19°C in a rod-like morphology in 0.05 M magnesium acetate, 10%(w/v) PEG 8000, 0.1 M sodium acetate (condition H9 from The PEGs II Suite, Qiagen).
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PMC6102174
Its structure was determined by extensive HRESIMS, 1D and 2D NMR spectroscopic data, and GIAO C NMR calculation.
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PMC11763111
This approach demonstrated that electroporation with a combination of multiple sgRNAs achieved 50% knockout efficiency compared to mock T cells electroporated without sgRNA.
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PMC7762347
The formation of DSB is followed by phosphorylation of the histone H2AX .
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PMC10170482
Mitochondrial membrane potential changes were analyzed using a previously described methodology.
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PMC11063646
The design expert recommended an optimal formulation with 4.66 % xanthan gum and 6.59 % flaxseed oil.
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PMC9429973
Summary/Conclusion: Patients ≥80 years of age account for more than 20% of de novo and relapsed myeloma patients treated in EMMY.
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PMC9856122
The structure–activity relationship of protoberberine alkaloids indicates that linkage between C2 and C3, a quaternary nitrogen atom and substitution with hexyl and methyl is important for anti-HIV, anti-HBV, and anti-polio activities (Figure 3).
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PMC10452486
Such homo- and heterodimers may function through differential binding to the LILRBI family of receptors .
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PMC11476004
The SCE assay used to identify chromosomal instabilities is a pioneering test.
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PMC10203589
Therefore, FGF18 has a significant relevance in OC cancer stem cell properties, and the pathways through which FGF18 mediates OC progression are very rich, and there are many more sites that still need to be explored.
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PMC9910796
Altogether, these results indicate that pEP84R is required for the correct targeting of the core shell precursors to the ER-derived inner viral envelope.
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PMC6889484
Either CEM and PM1 cells were transduced with the A33G(DK) or A3x3G(DK) lentivectors and placed directly on puromycin selection, or eYFP cells were first sorted using flow cytometry and then placed on puromycin selection (Figure 2B).
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PMC10440586
Overexpression of CD99 implies a higher level of hypoxic responses, including the initiation of transcriptional programs and metabolic reprogramming.
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PMC8540692
Contrarily, CCM upregulated its expression.
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PMC11705547
Interestingly, cisplatin can mediate development of drug resistance through M2-like polarization of TAMs by upregulating IL-34.
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PMC11188874
Here, we discovered that histone deacetylase 6 (HDAC6)-selective inhibitors not only increased proteasome activity but enhanced antigen presentation and promoted CTL-mediated tumor lysis.
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PMC7961460
On the other hand, the surrounding stroma must provide support, nourishment, protection from the immune system and drug activity to the cancer cells, involving a variety of molecules and metabolites .
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PMC11683240
Subsequently, cells were washed by centrifugation, and different concentrations of α1AT or the respective amount of solvent (H2O) were added to the cells and incubated for further 15 min at 4 °C.
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PMC11569208
We then secondarily demonstrated that upon cloning of an ACP2-targeting shRNA into a VSV∆51 backbone, the resulting VSV∆51-shACP2 virus exhibited increased infectivity and cytotoxicity over its non-targeting control counterpart in multiple cancer cell lines.
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PMC11335267
However, no differences were observed in locomotor activity between Alx3-mutant and wild type animals (Fig. 3E, Supplementary Fig. 3E and Supplementary Table 3).
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PMC10831439
α-GalCer did not promote any further enhancement of the cytotoxic activity in this setting.
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PMC5716223
a MTS viability assay.
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PMC9429973
Demographics were expressed by descriptive statistics.
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PMC8978939
MMPBSA, Molecular Mechanics Poisson-Boltzmann Surface Area MMPBSA.
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PMC11754432
A Representative images from dual immunofluorescence and RNAscope in human skin for ALOX15B (yellow, protein; magenta, RNA) and CD68 (cyan, macrophages).
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PMC6650823
This prodrug design appears to offer a viable strategy for addressing solubility issues of sterically hindered alcohols .
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PMC9429973
Cytoreduction consisted of hydroxyurea in 124 patients (96%), cytarabine in 69 patients (54%) and leukapheresis in 31 patients (24%).
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PMC9429973
V. Hanes, J. Pan, D. Mytych, V. Chow Amgen Inc, Thousand Oaks, United States of America Background: ABP 959 is being developed as a biosimilar to eculizumab reference product (RP).
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PMC11502443
However, maximal levels of IP1 accumulation, AKT phosphorylation and ERK phosphorylation were significantly lower for the E354Q variant.
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PMC7841189
These data suggest that knockdown of LTBP2 inhibits thyroid carcinoma cell migration and invasion through suppression of the EMT process.
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PMC8875242
On the contrary, the Caco-2 cell line expresses higher levels of some uptake transporters, which could lead to the increased intracellular concentration of the antivirals, leading to the more significant ABCB1 inhibition .
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PMC11679033
Exposure to a single CIT under the same experimental conditions showed clear toxic effects using all methods.
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PMC11548041
Therapeutic MNVs were functionalized with 1 μM Cy5-PLD01-TEGChol (T-tMNVs) or left unfunctionalized as controls (tMNVs).
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PMC10734950
When examined in the flow cytometer, cells emitting only a green fluorescence signal (~529 nm) indicate mitochondrial depolarization (damage).
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PMC11473843
The complete list of plasmids used are reported in the Reagents Table.
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PMC4277423
DPI: days post infection.
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PMC10999934
From the interaction network module, we found that some genes were related to ovarian cancer and immune interactions with FBXO2.
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PMC10344560
After the catheter removal, we observed no black debris reappeared in his catheter lumen.
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PMC8193046
Cyclosporine A (2) was used as standard ABCB1 inhibitor in the presented study.
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PMC8193046
Indeed, pyrimidine and pyridine could not be considered as clear positive hits in our previous study because many compounds of the other classes 0–6 contained these substructures as well (407 and 209 molecules, respectively).
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PMC11036064
Then, we studied the expression level of hsa-miR-34a-5p in GBM and non-tumoral brain tissues.
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PMC10998613
A (red autocorrelation), B (green autocorrelation), and X (cross-correlation) functions were then applied to data, generating curves for each individual acquisition, for a total of six sets of curves for each cell and are described below.
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PMC9874064
3 In vitro anti-tumor effect of NP-Pt-USP1i.
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PMC11098378
It was therefore notable that two effectors, HopAM1 and HopT1-2, rescued arbovirus replication within the insect cells.
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PMC9429973
Acknowledging the generally reported impaired outcome of MM pts showing severe renal impairment, PFS and OS underline the importance of effective MM regimens which can be safely administered in a difficult to treat population.
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PMC3734024
Among these cells are the recently-identified populations of innate lymphoid cells –. These cells are the major producers of IL-5 under homeostatic conditions, and while present but infrequent in the spleen, they are heavily enriched in locations where immunoregulation is essential for maintaining tolerance to innocuous environmental antigens and commensal microbes, such as lymphoid structures associated with the lung and intestine.
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PMC9429973
For the entire cohort, the 3-year continuous remission and OS rates were 84% and 85%, respectively (Figure 1).
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PMC10380508
The loss of VHL is observed in approximately 90% of KIRCs and leads to stabilization of HIF2A.
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PMC9429973
Both inhibitors induced cell death by apoptosis since an increase in the percentage of cells in late apoptosis was observed.
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PMC3931643
Gene specific primers were used to amplify MCL-1, Cyclin D3 and Actin using the Step One Real time PCR system and relative quantification of the transcripts was done using the delta delta cT method.
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PMC6835762
They also moved from a magnetic to a mechanical stirrer, in order to increase the size of the reaction pot with a view to scale-up the synthesis and thus facilitate further functionalization .
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PMC11738017
Surprisingly, GSI potentiated the anti-BCMA TCE activity only in tumors with high sBCMA levels (OPM2_BCMA), independent of the E:T ratio, by reducing their sBCMA to levels comparable with that of parental OPM2 cells and significantly increasing mBCMA (as shown in Figure 3F-H).
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PMC11791203
The petroleum ether extract also showed cytotoxicity against HT29 cells (IC50 = 76.58 ± 4.74 µg/mL).
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PMC11612315
cDNA constructs of rat TRPV1 were transiently transfected into cells via Lipofectamine 2000 (Invitrogen).
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PMC9429973
In relapsed/refractory (R/R) patients (pts), data regarding outcomes of salvage chemotherapy according to easily acquired TME variables such as percentage (%) of infiltrating T- lymphocytes (TL) is scarce.
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