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PMC11676169
Our results suggest that, in T-ALL, BCAT1 possesses non-metabolic functions that confer a drug resistance mechanism and that targeting BCAT1 activity presents a novel strategy to improve chemotherapy response in T-ALL patients.
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PMC10854447
H NMR spectrum of compound 7g confirmed the elucidated structure by showing a singlet triazole C–H signal at δ = 8.82 ppm, and nine aromatic protons appeared as five distinct signals in the aromatic region.
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PMC11758416
Resuspend centrifuged cells in 1 mL of T cell media.d.
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PMC11791203
Also for the first time the present study showed the anticancer potential and the phytochemical composition of extract from H. malabarica.
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PMC4277423
Interestingly, we observed that although CCR5 gene disruption could be detected at 3 days post transduction, the disruption continued increasing until 9 days post transduction (Wang et al. data not shown).
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PMC11752767
Furthermore, NK cells directly recruit dendritic cells (DCs) to the tumor microenvironment and stimulate their maturation via CC-chemokine ligand 5 (CCL5), XC-chemokine ligand 1 (XCL1), and FMS-related tyrosine kinase 3 ligand (FLT3L) .
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PMC11634794
Each dataset is presented as mean ± standard deviation, while a significance level of P < 0.05 is considered statistically significant.
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PMC11615828
One of the major components of IFT, IFT88, a ciliary membrane protein, 5HT6, and an axonemal MT‐binding protein, MAP4m, were used for real‐time visualizing IFT motility, cilia morphology, and axonemal MTs, respectively (Figure 4a).
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PMC9429973
Given the ubiquitous nature of aldehydes in our own body, can aldehydes contribute to the ageing of HSCs in haematopoiesis?
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PMC11575040
Numerous lncRNAs were detected, but only a small fraction were identified as differentially expressed (fold change greater than 2 or less than 0.5) in melanoma cells treated with metformin compared to the control group (Figure S1B).
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PMC11534377
Post-acquisition image processing was performed using ImageJ. Cells grown in chamber slides were permeabilized using 0.5% Triton X and stained with CytoPainter Mitochondrial Staining Kit – Red Fluorescence (Abcam, Cambridge, UK) for one hour, in fresh PBS, at 37°C, under 5% CO2.
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PMC11240571
To examine whether irradiation to tumor cells induced exosomal PD-L1 release, the exosomal fractions from the culture media of irradiated HT1080 cells and 143B cells were investigated.
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PMC11756514
Overnight cultures were subcultured in fresh THB and cultivated to an OD600 ~0.6.
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PMC10033453
Single-cell suspensions were isolated from freshly collected murine tumor tissue and viably cryopreserved.
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PMC9429973
DIHRMS detects a wide range of RBC and plasma metabolites, whereas the quantitative measurement is restricted to measuring 2,3-DPG of RBCs.
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PMC11763126
In ccRCC, TRPM3 enhances tumor growth and induces autophagy through the activation of specific cellular pathways .
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PMC10502403
αβ-TCR-engineered γδ-T cells were prepared as follows: Lymphocytes were isolated from the peripheral blood of healthy donors.
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PMC11790599
Eventually, the massive macropinosomes fill the cell, leading to membrane rupture.
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PMC11592837
For automated microscopy, we used the AKLIDES system (Medipan, Germany) as previously described in detail .
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PMC9429973
Cytogenetics were normal.
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PMC8358006
We used Metascape for pathway analysis.
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PMC9684669
All statistical analysis was performed using a two-tailed t-test (*** p < 0.001).
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PMC9878562
Similarly, only a small fraction of DOHH2 expressed ACKR3 on the plasma membrane ( Figure 1A ).
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PMC10158546
However, we noticed regulation of PrP during ReN cell differentiation and observed modulated formation of spheroid-like structures by ReN cells that express different levels of PrP. We report these findings because they are consistent with the role of PrP as a regulator of neurogenesis and neuron differentiation .
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PMC6442998
Immediately before use, 1 μl of 30% H2O2 (Merck, Darmstadt, Germany) was added.
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PMC11593084
The VH cDNA of PMab-117 and the CH of mouse IgG2a were cloned into the pCAG-Neo vector [FUJIFILM Wako Pure Chemical Corporation (Wako), Osaka, Japan].
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PMC11680578
Compusyn software was used to find out the combination index value for the synergistic treatment of RGZ and PTX.
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PMC9429973
4, 73 (2021).
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PMC11724582
cDNA synthesis was performed using the HiScript III All-in-One RT SuperMix Perfect for qPCR (Cat.
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PMC6163708
In GANT61-resistant cells, antiapoptotic signals ensuring tumor progression can maintain apoptosis by other pathways.
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PMC11746948
The numbers in the figure represent the palmitoylated proteins identified in each sample (with proteins identified in the HAM group excluded).
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PMC6835762
In addition, PGA and its modifications have shown good propensity to produce printable polymeric ink, even at relatively high concentration and in different printing scenarios: both in a solid state and for nanosuspension screening .
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PMC11590005
The snowball sampling method facilitated access to participants, considering the geographical size of Brazil, but lim-ited direct interaction with the researchers.
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PMC8973085
The H-acceptor interaction with HIS-62 is the common type of interaction in derivatives 4f and 7b (Table 4 and Figure 8).
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PMC3019555
Immunoblot of HIF-1α and GAPDH after 4-h hypoxia (Table I).
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PMC11552389
Scale bar: 10 μm. **
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PMC11657744
Cells gradually entered mitosis within 24 h and disassembled the primary cilia.
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PMC11047729
In the study performed on the U937 cells, different doses of the substance were added and the cells were incubated for 48 h. The hTERT mRNA expression was inhibited and was the most effective with a concentration of 75 nM, whereas TEP-1 and hTERT mRNA expression remained unchanged .
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PMC5535901
Of note, I3C, only at 50 µM, showed maximal induction of these pro-inflammatory cytokines, whereas DIM showed a dose-dependent effect.
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PMC11777207
Human moDCs and murine BMDCs were treated with LPS (Invivogen) at a concentration of 200 ng/ml) for 4 hours.
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PMC11775197
They function as transcription factors and can participate in tumorigenesis, cell proliferation, angiogenesis, cell death, invasion, migration, and tumor metabolic processes.
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PMC7812570
TZM-bl cells were then transduced with the recombinant lentiviruses and sorted by fluorescence-activated cell sorting (FACS) to isolate a cell population in which close to 100% of the cells expressed GPI-anchored m36.4 (GPI-m36.4) or FluIgG03 scFv (GPI-FluIgG03).
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PMC11206502
The association of the Warburg effect in cancers with tumor-related autophagy may be relevant for the further development of experimental therapeutics and cancer prevention.
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PMC9964654
Using ACN as a solubilization agent led to the lowest [Au(cdc)2] LC results; in fact, in the case of formulation AS2, no gold-complex encapsulation was obtained.
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PMC11171319
The alternance of lytic and latent phases occurs during the pathogenesis of oncoviruses of the Herpesviridae family, namely EBV and KSHV, with viral reactivation triggered by immune suppression and inflammation .
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PMC11701801
The specimens were dehydrated by passage through a series of ethanol solutions, beginning with 70% ethanol and finishing with 100% ethanol.
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PMC7602170
In summary, eIFs integrate the signals from the PI3K/AKT/mTOR pathway, which may be a promising target for tumor therapy in future.
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PMC11694346
Additionally, concentration titration experiments ranging from pure BT-DNBS to varying concentrations of biothiols (0–1000 μM) revealed a good linear relationship (ESI†).
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PMC11295144
Quantitative analysis of the % area of synaptic contacts formed with α2β2γ2-GABAA receptor/NL2-expressing HEK293 cells.
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PMC11742670
Table 2Summary of Generated and selected descriptors for each cancer cell line.
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PMC11244823
COS-7 cells (kindly provided by Ola Sabet, University of Zurich) were grown in 75cm tissue culture flasks (TPP AG, Trasadingen, Switzerland) with Dulbecco’s Modified Eagle’s Medium (DMEM; Gibco, Carlsbad, USA) supplemented with 10% fetal bovine serum (FBS) (BioConcept, Allschwil, Switzerland) and 1% of antibiotic-antimycotic solution (Gibco) at 37°C and 5% CO2.
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PMC11711063
Comparison of cell migration upon treatment with conditioned supernatants for 24 h. (J) Comparison of cell migration following pre‐treatment with vehicle or Bex + Carv (1 μM each) for 48 h. The transcriptomic profile of ZG16B‐treated HME‐hTert cells revealed the overrepresentation of matrix‐related genes, consisting of over 50% showing greater than 10% inductions (FDR <0.1%) (Table 1).
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PMC11711871
E Measurement of the adrenal weight/body weight ratio (GR, n = 12; GR, n = 14) and F cortex (left) and medulla (right panel) size (GR (n = 3) and GR (n = 4)).
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PMC11739504
Western blot data showing an increase in Kat2b protein expression during ciliogenesis. (
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PMC6222726
Koulman isolated three lignans from this species: hinokinin (1), savinin (2), and cubebin (3) (Figure 1) .
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PMC11454387
Disclosure: G. Sakalauskaite: None.
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PMC11611077
The electromotility of outer hair cell is considered to be based on voltage-dependent conformational changes in the motor protein prestin.
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PMC9429973
To date, hundreds of fusion genes resulting from chromosomal rearrangements have been identified in acute leukemia.
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PMC11314247
Subsequently, the mixture was stirred for 3 h. The compound was obtained via distillate hexane extraction, and the solid formed was filtered and washed with hexane (Scheme 1).
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PMC11754432
Morphology of the skin equivalents was assessed with haematoxylin and eosin staining.
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PMC9712534
The mobile fractions were estimated to be 0.86 ± 0.06 (DMSO) and 0.20 ± 0.03 (ICRF).
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PMC9370419
We utilized the quantitative NanoLuc-based HiBiT detection system.
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PMC10965680
Whole-genome resequencing data encompassing a total of 159 goats were leveraged.
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PMC5311252
Finally, the discovery of oncomiRs and TS miRNAs during the last 15 years spawned the idea of targeting miRNAs for cancer treatment.
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PMC6268318
Medicinal plants have been used since ancient times in virtually all cultures as a source of medicines , and are of great importance to the health of individuals and communities .
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PMC3765139
Interestingly, the only modification observed in 3D as compared to the 2D cultures was represented by a modest increase of the fraction of CD133+ cells in the Na8 cell line (Figure 3).
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PMC11529598
A. Migration ability of miR-3154 sponge U251 cells and control U251 cells was measured using Transwell assay. *
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PMC10507284
Meantime, the expression of TROAP is different under distinct histological conditions (Figure 1F).
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PMC4395774
Five different genetic loci have now been identified (FHL 1–5), and of these, perforin deficiency (FHL-2) is the most common and best characterized.
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PMC10565698
A-B. Tumor growth after 28 days.
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PMC6468656
Importantly, cancer metastasis is a complicated process that requires multiple factors to elicit tumor invasion at the primary site.
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PMC11596967
Antioxidant peptides (AOPs) have emerged as effective countermeasures against ROS-induced damage.
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PMC11441402
The MTT and SRB assay overestimated cell death in MALME-3M adherent melanoma cells treated with H2O2, however this was not seen in SK-MEL-2 adherent melanoma cells and there was no difference when assessing the effect of portimine on both cell lines.
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PMC2193049
The amount of TNF-α produced by CTL incubated with cells expressing MAGE-31–314 was not significantly higher than that produced by CTL incubated with mock-transfected cells (Fig. 3).
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PMC11694625
67%.
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PMC11747467
After 24 h, RC48 and ART were added at previously set concentrations and incubated for 48 h. The medium was then replaced with CCK8 at a ratio of 10:1 (APE×BIO, USA) for 2–4 h. Cell viability was subsequently measured based on optical density at 450 nm.
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PMC7452526
Silver nanoparticles are widely used in many fields especially at medical and health fields because of their unique physicochemical, and biological therapeutic properties as antibacterial antiviral , antifungal , anti-inflammatory and anticancer .
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PMC11766309
Moreover, dual immune checkpoint inhibitor (ICI) combination therapy, which involves coinhibition of PD-1/PD-L1 in cancer immunotherapy, has become a promising therapy for enhancing the benefits gained from ICI treatment.
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PMC9429973
A. Zaninoni, R. Russo, R. Marra, I. Andolfo, E. Fermo, A. P. Marcello, D. Consonni, B. Eleni Rosato, S. Martone, B. Fattizzo, W. Barcellini, A. Iolascon, P. Bianchi Hematology Unit - Physiopathology of Anemias Unit, Foundation IRCCS Cà Granda Policlinico Milan, Milan; Department of Molecular Medicine and Medical Biotechnology; CEINGE – Advanced Biotechnologies, University Federico II, Naples; Epidemiology Unit, Foundation IRCCS Cà Granda Policlinico Milan, Milan, Italy Background: Iron loading anemias are characterized by ineffective erythropoiesis and iron overload.
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PMC11583010
As expected, the presence of a nectin-4–expressing tumor mass constituted a sink for ETx-22.
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PMC9429973
The inclusion criteria were: 1) CVT confirmed by imaging (angiography,CT,MRI,MRV) 2) any type of anticoagulation 3) sample size>5 & 4) age>16 years Results: 25 studies were included with a total number of 2320 patients.
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PMC11762280
B Images of H&E staining of human skin explants from 3 samples.
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PMC9429973
PICRUSt2 was used to predict metagenomic functions based on as Kyoto Encyclopaedia of Genes and Genomes (KEGG) ortholog.
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PMC11634794
After air-drying, the colonies containing more than 50 cells per well were visually documented and quantified.
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PMC11759751
CD19 CAR T cells could effectively kill B-NHL cells with positive CD19 expression, and the ability of CD19 CAR T cells to kill Raji, Ramos and SU-DHL-4 gradually increased with the increase of efficacy target ratio (Fig. 1C).Fig.
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PMC11180402
As shown in Fig. 5B-5C, similar to ISO treatment, miR-129 overexpression not only inhibited SNHG1 expression but also consistently altered SOX2, MMP-2, MMP-9, and PTEN protein levels in 5637 cells.
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PMC8009078
In addition, the flavone 5 hydroxy group to form HB interactions with Arg55 and Gln374 with an interatomic distance of 3.49–3.63 Å. Another pyrin ring contains a methyl group present in the flavone ring to form HB interactions with Gln371 and Leu378 with interatomic distance 3.65–3.339 Å, respectively.
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PMC11684269
Within the pathogenesis of kidney disease, different TRMs fulfill its function.
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PMC9872547
The improvement of the anti-proliferative function of curcumin in different cancer cells can occur by using nano-types.
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PMC4005030
for 45 days) administration in rats was found to be highly beneficial in protecting against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant.
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PMC10719213
At 5 nM cladribine concentration during a 4-day incubation, we observed a modest 10.4% increase in cell death in cladribine-treated versus nontreated cells.
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PMC8097906
The hMSCs were not affected by the VSM treatment (Fig. 6a), whereas the cell viability of NHDF control cells were slightly influenced in a biphasic manner (Fig. 6b).
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PMC6190245
Other pharmacological effects of this plant include anticonvulsant, anti-neurological disorders, anti-diabetes, anti-rheumatic and anti-inflammatory activities.
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PMC10887351
At present, among the β3-AR agonists, mirabegron has shown to be the most promising treatment in over 30 years for the oral pharmacotherapy in patients affected by overactive bladder syndrome.
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PMC11594588
The induction of mitochondrial oxidative stress destabilizes the redox processes occurring, disrupting the integrity of mitochondrial membranes.
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PMC11721295
To generate a mouse model wherein oncogenic KRAS can be induced and reversed in the lung with accompanying mutant-p53 expression, we crossed the bitransgenic Ccsp-rtTa; TetO-Kras mouse (8) with the Trp53 mouse (8, 14).
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PMC6948907
The cells were treated with various doses of genistein and valproic acid (alone and combined) and the MTT assay and flow cytometry were used to determine cell viability and apoptosis.
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PMC11705067
The Top 20 up- and down-regulated genes from ccRCC patients were exhibited in the heatmap (Fig. 1B).
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PMC11612626
The HDAC-targeted library contains 9,760 screening compounds that undergo thorough quality control assessments using LC/MS and/or H NMR to guarantee a purity threshold of >90%.
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PMC5025404
LC adalimumab, the synthetic gene of the light chain mAb for adalimumab, codon optimized sequence; CMV promoter, the early gene promoter of human cytomegalovirus HCMV IE1; Neo neomycin phosphotransferase Construct of pcDNA-LC adalimumab, containing the adalimumab light chain.
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