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PMC11733919
It should be highlighted that the senolytic activity of HSP90 inhibitors was documented against senescent normal cells and their effects against senescent cancer cells were not established.
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PMC9454178
Statically significant differences were considered when P < 0.05.
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PMC10123657
The stringent criteria described in the Materials and Methods section led to the identification of 67 mouse proteins in co-cultured CCRF-CEM cells (Supplementary Table S1) suggesting that these proteins may have been transferred from MSC to leukemic blast cells during the co-culture period.
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PMC10926885
These changes determine how sensitive tumour immunotherapy is to treatment.
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PMC11684297
3 × 10 A375 cells per well were cultured in a six-well plate and incubated with complete DMEM (DMEM containing 10% FBS and 1% antibiotic solution) for 24 h for cell attachment.
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PMC11686380
Sholl test was conducted to quantify branch points of dendrites in (A).
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PMC9429973
Whether cellular immune response is also abrogated is unknown.
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PMC11128598
In fact, it is considered one of the most prominent instances of drug repurposing in cancer (7).
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PMC11753949
Plots were prepared using MATLAB.
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PMC10170482
This two-color fluorescence cell viability assay is based on the ability of calcein-AM to be retained within live cells, inducing an intense uniform green fluorescence and EthD-1 to bind the nuclei of damaged cells, thus producing a bright red fluorescence in dead cells.
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PMC9473868
Cell migration was detected by scratch healing assay under BAI treatment in SW982 cells.
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PMC3765139
Comparative immunohistochemistry was performed on xenografts and primary human melanoma sections.
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PMC11566417
By introducing hTERT to primary MDECs, we found that MDECs can be immortalized, and that the secretome of high passage immortalized MDECs has antimicrobial, pro-migratory, and immunomodulatory effects on target cells.
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PMC9429973
Developmental Tumors Biology Group; Developmental Tumor Biology Laboratory, Institut de Recerca Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid; Pediatric Hematology and Oncology Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain Background: MicroRNAs (miRNAs) regulate gene expression and may function as tumor suppressors or cancer promoters.
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PMC11792740
T-cell depletion refers to the gradual decline in the proliferation, cytokine production, and cytotoxic effects of T cells during a sustained antitumor immune response, ultimately resulting in weakened antitumor immune function.
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PMC10092581
A and B) TrxR1 activity was assayed by measuring NADPH‐dependent reduction of DTNB at 412 nm as described in the Experimental Section.
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PMC10891340
In this study, we tested the antiviral effect of the carbonyl cyanide m-chlorophenyl hydrazone (CCCP), a common mitochondrial autophagy inducer.
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PMC6684588
Data are means ± SEM (n = 8–9). **
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PMC11680982
Collectively, these findings indicated that CDK4/6 inhibitor combined with endocrine therapy is effective in treating HR/HER2-low breast cancer, but with lower efficacy compared with HR/HER2-0 breast cancer.
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PMC11599565
The treatment of OC is based on surgery and chemotherapy with platinum- and taxane-based compounds.
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PMC6034753
Using a combination of Meq mutagenesis and co-immunoprecipitation, we demonstrate that apoptin interacts with Meq within a region between amino acids 130 and 140.
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PMC11344246
RNAseq and organoid data. (
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PMC10421378
Differential scanning calorimetry is a method that is well suited for measuring such changes in biological systems.
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PMC10957991
In turn, we detected changes in the levels of CK5, a stem and progenitor cell marker, which in our previous studies was found to act as a regulator of the lineage-specific differentiation of the mammary epithelial cells (Fig. 2).
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PMC6600253
Senescence occurs in several tissues during different physiological and pathological processes, such as tissue remodeling, injury repair, cancer, and aging .
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PMC11093197
RB1 mutation or deletion contributes to the initiation of limited types of cancer, including small‐cell lung cancer and retinoblastoma.
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PMC9429973
At study entry, ISS stage II–III was 67% in IV, 33% in SC1000, 60% in SC1400, and 50% in OBDS pts.
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PMC9429973
As treatment lines progress, therapeutic combinations are more heterogeneous and less concordant.
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PMC9776316
Therefore, the cJUN-JNK-XRCC4 pathway contributes to cisplatin resistance in ovarian cancer.
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PMC10154881
This study was supported by Health and Labour Sciences Research Grants (15ck0106001h0003), AMED (19ck0106281h0003), and JSPS KAKENHI (grant number 21K07116).
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PMC10125312
Differences in the increase of temperature can be the result of the different amount of internalized nanoparticles and the total amount of gold in the suspension which will elicit different responses from the cells.
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PMC11413393
Cells were typsinized and pelleted by centrifugation at 300 × g for 5 min.
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PMC10993311
To ensure accuracy and reproducibility of the measurements, the researchers attended a dedicated training course.
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PMC8735881
The results of three independent experiments are shown with different colours of lines.
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PMC11767725
Dysregulated secretion of adipokines, including elevated leptin and resistin, contributes to inflammation and metabolic dysfunction.
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PMC11711127
In conclusion, the intricate exploration of diverse T cell resistance mechanisms not only reveals the complex challenges within the immune landscape but also unveils promising avenues for therapeutic interventions across a spectrum of diseases.
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PMC9429973
All of the 6 (100%) TN pts achieved CR.
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PMC11748335
Originally identified in ESCs, poised promoters are thought to be readily convertible to either active or repressive states, playing a key role in sustaining stem cell pluripotency, whereas differentiated cells lose poised promoters [51–53].
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PMC11789597
Thus, a total of 1087 FDA‐approved drugs were screened using an in‐cell western assay to find those that inhibit CAV1 effectively to facilitate clinical translation (Figure 7A).
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PMC10890307
This can occur when non-transformed cells have high glucose consumption rates, which can happen when cells are involved in inflammatory processes such as infections or injuries .
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PMC11435360
In this study, we observed a decrease in VEGF expression following monotherapy with PAG and GEM, and a further reduction after combination therapy, which poses another explanation for the additive effect of PAG during chemotherapy.
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PMC11472639
SSC-A, side scatter-area; FSC-A, forward scatter-area; FSC-H, forward scatter-height; SMM, smouldering multiple myeloma.
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PMC11782508
Similarly, studies using the p28 peptide derived from azurin (Leu50-Asp77) reported significant reductions in ZR-75-1 breast cancer cells.
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PMC9429973
Over a median follow-up duration of 34 months, the median OS was 86 months.
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PMC11012012
SLAMF5/CD84 and SLAMF7/CD319 were also upregulated in DLBCL and PBL/PEL, respectively.
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PMC8633974
We next sought to determine whether proviral DNA excision induced by two CRISPR-Cas9 gRNAs would further suppress HIV-1 replication.
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PMC11766309
In the next step, we analyzed the prognostic significance of YKT6 across cancers via Kaplan‒Meier survival analysis by mining the TCGA database.
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PMC9429973
Median OS was 12.3 months (95% CI, 7.4-17.2) compared with 29 months (95% CI, 2.1-55.6) in patients with or without CL, respectively (P = 0.007).
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PMC9429973
Our team includes dental consultants, specialty trainees and hospital grade dentists who work closely with haematology colleagues within our hospital and others.
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PMC7570809
15,000 cells/well were incubated in the presence of peptides (50 μM) or antibodies (10 μg/mL) at 4 °C for 30 min as previously reported and then cells were seeded on coated plates for 1 h. Non adherent cells were gently removed by repeated washing and adherent cell number was evaluated by crystal violet (Sigma Aldrich) assay, which correlates optical density with cell number.
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PMC11321678
NTR‐TF regulatory network is cluster specific.
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PMC5673060
This panel comprised of kinase inhibitors targeting the major cellular signalling pathways important for cancer cell survival as well as inhibitors that target the BET bromodomain proteins (JQ1) and the HSP90 protein (NVP-AUY-922) which are currently in advanced clinical trials (Table S3).
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PMC11708541
Additionally, immunohistochemistry analyses of injured nerves treated with (4-AP)-PLGA-PEG showed elevated neurofilament heavy expression.
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PMC11670954
Representative images of immunofluorescence staining for RhoA, ROCK2, and MLCK (antibodies, green) and nuclei (DAPI, blue) (scale bar = 20 μm).
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PMC9412887
The above results confirmed that erlotinib, PFOB and HP could generate synergistic effects to improve the antitumor effect and reverse EGFR-TKI resistance by combination of erlotinib and SDT.
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PMC11544771
To substantiate this finding, A549 cells were treated with CPX (5 μM) or PRE (20 nM) alone or in combination for 48 h, and then pulsed with BrdU for 3 h, followed by BrdU immunofluorescence staining.
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PMC9429973
Response and progression were assessed by the Onyx Response Computer Algorithm using IMWG criteria.
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PMC11714165
Bone slices were purchased form IDS PLC (DT‐1BON1000‐96, UK).
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PMC9596868
Data presented are mean ± SD from three biological repeats analysed by ANOVA with Bonferroni's Multiple Comparison test. (*
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PMC10936243
So, we are not able to provide bedding for each one of them, as it will cost a lot…” [D081].In general, all the veterinarians interviewed employed a limited number of staff in their practices.
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PMC11335267
Left panel, western blots showing levels of tyrosine hydroxylase (TH) and vinculin (Vin) as a loading control.
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PMC11661024
This points out that the impact of these postbiotics differs among cancerous and normal cells, which could be considered an optimistic feature of the treatment and control of cervical malignancy.
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PMC9429973
Methods: Utilizing an accelerated titration design, doses of BMF-219 will be escalated in single-subject cohorts independently for each indication until 1 subject experiences either a ≥ Grade 2 related adverse event or dose limiting toxicity (DLT).
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PMC9429973
Most (83.3%) of these patients were hospitalized owing to onset of infection; however, one patient (white male; 43 years old; ravulizumab to ravulizumab) was hospitalized owing to worsening of aplastic anemia.
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PMC11705862
However, we found no IRIS-1 or IRIS-2 secreted into the extracellular environment, but rather found that these proteins are retained intracellularly within the cytosol.
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PMC8864075
The siRNA sequences were as follows: TWIST1 (sense: 5′-CAA​GAU​UCA​GAC​CCU​CAA​GTT-3′, antisense: 5′-CUU​GAG​GGU​CUG​AAU​CUU​GTT-3′); GAPDH (sense: 5′-AAT​GGG​CAG​CCG​TTA​GGA​AA-3′, antisense: 5′-TGA​AGG​GGT​CAT​TGA​TGG​CA-3′).
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PMC11724582
No. R333-01; Vazyme Biotech Co., Ltd.).
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PMC11731614
KDEVs are retrogradely trafficked into the neuron cell body through the neurites in a microfluidic paradigm.
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PMC9429973
With a median follow-up of 62 months, no significant differences were observed in OS between the two regimens, and median survival was not achieved in neither group (see Table and Figure).
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PMC10955424
Ruxolitinib, tofacitinib, dasatinib and crizotinib obtained from Selleck Chemicals LLC (# S1378, # S2789, #S1021 and #S1068, respectively, Houston, TX, USA) and platinum IV prodrug RJY13 .
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PMC11732628
The 143B cells were fixed with 4% paraformaldehyde and incubated with proteinase K according to the manufacturer’s instructions.
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PMC11377827
It is possible that there is redundancy or cell type specificity within DUBs reversing VHL-mediated ubiquitination.
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PMC11802855
Survival analysis, based on the optimal cutoff value, revealed that higher CXCL7 expression was significantly associated with shorter OS time (P = 0.006) (Fig. 3H).
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PMC11768281
In addition, the immunotherapy targets identified are summarized in Table 2, which categorizes them based on T-cell activation stages (pre-activation, activation, and post-activation), highlighting their mechanisms of action and experimental outcomes.
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PMC9599726
VP is a photosensitizer used to treat macular degeneration and has been shown to inhibit YAP-TEAD interaction independently of light .
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PMC9429973
The median (range) duration of exposure to eltrombopag was 258.5 (69-443) days, and the median (range) daily dose was 122.8 (26-138) mg/day.
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PMC11422497
HEK293T cells at 30% confluence were carefully seeded into 24-well plates.
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PMC11552389
In this study, we revealed a significant decrease in FOXN3 expression in melanoma tissue compared to normal skin tissue samples, with this expression closely correlated with the activity of the Wnt signaling pathway.
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PMC9429973
Methods: Long-term HSCs (LT-HSCs) from Calr knockin mice were isolated for RNA-Seq.
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PMC6190245
At the next step, the effects of a combination of F. gummosa and radiation against the HeLa cells, were determined.
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PMC8633974
TatDE RNP and two HIV molecular clones (NL4-3 & pCH040.c/2625) were co-transfected HEK293FT cells using TransIT-X2 transfection reagent (Figure 7a).
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PMC11267036
Meanwhile, MM cell migration and invasion were notably restrained by DHM in a dose-dependent way.
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PMC10812665
Also, the levels of the N-rich AA Arg and Orn were increased.
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PMC9429973
Methods: We described 3 patients with combined mild-moderate FV+FVIII deficiency.
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PMC11588008
Compared with the blank group, the ROS and MDA levels in ovarian cancer cells in the model group increased significantly (P < 0.01).
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PMC7215832
Treatment with DAC also led to an increase in MGMT protein expression as seen with RX-3117 (Figure 2C).
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PMC9503669
For this assay, Nef was fused to non-fluorescent, complementary fragments of a yellow-shifted variant of green fluorescent protein (YFP).
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PMC9429973
Several studies validate ISS and R-ISS, but also models like the IMWG frailty score, R-MCI, MRP, CCI, IPSI, HCT-CI, KFI, CONUT score, and mSMART were represented in the literature search.
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PMC11240571
The resulting cells were pretreated for 30 min with exosomes isolated from HT1080 cells in the presence of anti-human PD-L1 (Merck Millipore, Burlington, MA, USA, cat.
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PMC9429973
The 5-year leukemia-free survival (LFS) was 42%, 77% and 95% for high, intermediate and low risk groups (p<0.001).
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PMC11413393
Primary antibody used: S9.6 (Fischer Scientific, #MABE1095MI, 1:100).
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PMC11803149
ns, not significant, *p <0.05, **p < 0.01, ***p<0.001, ****p<0.0001.
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PMC9429973
HRS orchestrate a lymphocyte-dominated tumor microenvironment (TME) that supports their survival and growth, suggesting that even circulating immune cells might be affected.
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PMC9429973
Abnormal hypusination and attenuated mitochondrial metabolism were hallmarks of progenitors with RP haploinsufficiency, highlighting RP-eIF5A interactions in regulating erythroid differentiation.
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PMC5173112
However, whether USP21 can regulate the protein stability of IL-8 needs further investigation.
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PMC11768281
Another lineage, Th17, works in tandem with Treg cells to modulate protective immunity.
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PMC11711127
Better characterisation of tolDC biology would also improve therapy as migration of tolDC to lymph nodes or specific tissues has been a significant challenge (79185).
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PMC10818573
Therefore, 39 °C was selected as the optimum reaction temperature for this system.
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PMC11209164
The IFN pathway which is induced among others by viral infection can activate a series of antiviral genes that effectively suppress viral replication.
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PMC9985266
The target bands were transferred to polyvinylidene fluoride (PVDF) membranes by taking 50 μg for 10% SDS–polyacrylamide gel electrophoresis (SDS‒PAGE) and using skim milk powder (5%) to block the PVDF membrane for 2 h. PVDF membranes were incubated with the following Abcam antibodies for 12 h at 4 °C: p38 (1:1000), IL-27 (1:1000), α-SMA (1:5000), p-ERK (1:1000), fibronectin (FN; 1:500), collagen I (COL I; 1:5000), LC3B (1:1000), Beclin1 (1:2000), p-p38 (1:1000), collagen III (COL III; 1:1000), ERK (1:1000), and β-actin (1:5000).
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