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OTAR3088
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PMC9429973
In the Phase I/II COMPOSER trial (NCT03157635), patients (pts) with PNH who were treatment-naive or switched from eculizumab were treated with crovalimab, a novel anti-C5 monoclonal antibody designed with Sequential Monoclonal Antibody Recycling Technology (Röth et al. Blood 2020).
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PMC11201989
To determine the role of PD-L1 on ciliogenesis, we knocked down PD-L1 with siRNA and found that depletion of PD-L1 (Supplemental Figure S4A) resulted in an increase in the average cilia length in serum-starved NIH3T3 cells as visualized by cilia markers Ac-α-tub and ADP-ribosylation factor-like 13b (Arl13b) (Figure 2A,B).
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PMC11737091
We subsequently validated our findings through an immunohistochemistry (IHC) assay of ccRCC clinical samples.
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PMC9429973
We describe the first real-world evidence prospective registry in pts with BPDCN receiving TAG.
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PMC6684588
The TA tendon suture was attached to a calibrated dual mode muscle lever system (model 305C-LR, Aurora Scientific).
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PMC10507284
Furthermore, we also developed a nomogram based on this model and the clinical characteristics of STS patients (Figure 3H), and the nomogram exhibits a preferable consistency with the actual observed value of STS (Figure S4).
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PMC9429973
We examined associations between the occurrence of acute chest syndrome, cerebral infarction and vaso-occlusive crisis (VOC) and known biomarkers such as fetal hemoglobin, blood viscosity as well as exploratory oxygen gradient ektacytometry-derived biomarkers in an adult cohort of 50 individuals with SCD (HbSS or HbS/β-thalassemia) and a pediatric cohort consisting of 177 children with SCD (HbSS or HbS/β-thalassemia).
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PMC10652261
Yield: 74%.
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PMC11536589
Pretreatment with 0.2 µM PKF-118-310 for 4 h and the other indicated drugs was carried out for 48 h. (I) The synergistic effects of MRTX1133 and PKF-118-310 were measured in MRTX1133-resistant PDAC cells.
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PMC11532793
Swish adjusts transcript replicate counts for sample-specific transcript length and sequencing depth via median-ratio size factors.
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PMC11670954
However, BA treatment partly reversed the changes in the expression of these mRNAs in Fig 4A–4C.
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PMC11782508
Notably, a functional 28-amino acid fragment of azurin, designated p28, has been approved by the Food and Drug Administration (FDA) as a safe and effective anticancer treatment for both adult and pediatric patients.
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PMC9545714
RIN number for all RNA samples was >8.
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PMC11591030
The gene expression of the signaling pathway-related factors in the CON and AOP groups was lower than that in the LPS + AOP and LPS + PDTC groups (p < 0.05).
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PMC11190062
MM is incurable, but several new treatment options in the last two decades have significantly increased life expectancy for the patients.
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PMC11666785
These elusive molecules has a PArticle Resolution shift (PAR-shift) towards single molecule limit, and thus have a better localization.
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PMC11607764
And immunotherapy has broad applicability in oncology.
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PMC11023271
Consistent with its role in skin development, germline deletion of ripk4 in mice resulted in embryonic lethality with severe epidermal defects , whereas keratinocyte-specific deletion of ripk4 led to thickened epidermis and impaired skin barrier formation in mice .
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PMC11478724
At a dose of 15 µg/ml, LDH concentration increased by 60% and cell viability decreased below 10%.
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PMC9596868
No. 15250061).
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PMC11519788
Nevertheless, its function in UBC remains largely unknown.
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PMC11499381
The N-terminal domains are extracellular, meaning that they are potentially more exposed to fixative and the subsequent pH changes/protein cross-linking that arises during the fixation procedure than the C-terminal fusions.
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PMC11785489
We mitigated technical confounding in our rCCA implementation.
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PMC9429973
Escherichia coli and Klebsiella pneumoniae constitute the major part in the structure of bloodstream pathogens.
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PMC11594074
In this method, the blue non-fluorescent resazurin is reduced to pink-fluorescent resorufin by metabolically active cells, allowing for a direct assessment of cell viability based on the measured fluorescence .
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PMC9024365
Graph depicts mean the area of M1-3, S2, M4, CT chimera clusters stratified for either co-localized or non-colocalized with SD4.
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PMC9712534
We observed that the Western blot signal of TOP2B was decreased by etoposide treatment in both H58Y/WT and WT/WT cells (Fig. 6a).
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PMC9429973
Aims: Characterize the immune populations in PB of patients with FL at diagnosis and at relapse, and compare them with healthy controls.
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PMC11774747
This is true across various CAR, including CD30, GD2 and HER2.
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PMC11736898
Expression levels were referenced to GAPDH using the comparative 2 method .
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PMC6222726
It is typically a small tree that grows up to 10 m tall, with a thickened trunk and thickened lower branches, with light gray to white peeling bark, with younger branches having a reddish color.
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PMC11026382
The data were again well described by the model (Fig. 2C, Supplementary Fig. 1b–d).
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PMC11543853
Therefore, it is likely that most, if not all enteroviruses can use endosome rupture to reach the cytoplasm.
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PMC11743316
One of the characteristics of cancer is the remodeling of energy metabolism, in which cancer cells cause alterations of their metabolism to accomplish rapid and aggressive multiplication .
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PMC10812665
The selected toxicants and their respective mechanisms of action are summarized below.
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PMC11742047
The modifications of the lipid classes agree with the research landscape offered in the scientific literature.
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PMC9386809
This complex (Cl2Zr–calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues.
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PMC7887261
Insertions (ins) or deletions (indels) have been understudied, though they are the second most abundant source of human genetic variation.
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PMC11092418
The effect of a range of selected agents including HER family members, cyclin-dependent kinase (CDK), Src, STAT3 and cytotoxic agent on the cell cycle distribution of HBCCLs was investigated using flow cytometry.
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PMC11732523
A third course of antiviral therapy for COVID-19 was not pursued due to gastrointestinal issues and concerns regarding hepatic and renal function.
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PMC9918897
These are assumed to contribute to the final in vitro results obtained by us.
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PMC11040965
These molecules may include Myc [24–27], sonic hedgehog , nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) , transforming growth factor beta , transcription factor Sp1 , and several long non-coding RNAs which act as miR29b sponges .
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PMC11612315
d Mean normalized 340/380 ratios of sequential proton-induced calcium increases (mean ± S.E.M.).
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PMC11687167
This finding revealed a cytokine-triggered regulatory network of PCSK9 expression associated with the JAK and ERK signaling pathways .
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PMC10547921
In addition, the “cage” structure of eribulin is in contact with the ribose moiety of the guanosine nucleotide.
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PMC11676169
After infection, T-ALL cells were selected for 3–7 days in puromycin before functional assays.
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PMC9352806
Total RNA of worms (∼3000 worms per sample) was extracted by a TaKaRa MiniBEST Universal RNA extraction kit (Takara Bio, DaLian, China), which was reverse-transcribed to cDNA using a PrimeScript RT Master Mix kit (Takara Bio, DaLian, China).
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PMC2196094
For this purpose, an unamplified cDNA library was screened for positive hybridization signals with a panel of probes.
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PMC8303372
All results are expressed as mean ± standard deviation taking into consideration at least three different experiments performed in duplicates.
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PMC11798926
Regions of interest (ROI) were drawn manually around the border of individual cells and integrated density (using a uniform threshold determined for each channel) was measured for both surface and total expression and used to generate a ratio.
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PMC9429973
When considering NHL the distance from the administration of RTX had a particular impact on the vaccination response: patients receiving the monoclonal antibody within 6 months had a poorer response to the vaccination (13% of positivity) than those who were treated with RTX after 6 and within 12 months (50%) and after 12 months (87%).
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PMC11564322
After enhanced chemiluminescence-based detection, the PVDF membranes were stripped with buffer containing 0.1% of SDS, 1.5% of glycin, and 1% of Tween-20 (pH = 2.2.).
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PMC10203589
Therefore, the adjustment of early lung cancer screening procedures and methods (123), the implementation of practices to reduce the risk of lung cancer, and the exploration of treatment processes to improve the prognosis of lung cancer are our top priorities.
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PMC6133382
The 3.5D8 line contained the same mutation, while 3.5D9 and 3.5A2 both had in-frame deletions of 24 and 30 nucleotides, respectively.
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PMC11774112
In this study, drug-loaded micelles were prepared by ultrasonic emulsification.
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PMC11552389
As such, FOXN3 may represent a relevant target for therapeutic interventions in patients suffering from drug-resistant melanoma.
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PMC10812665
After pre-incubation at 30 °C, reactions were put back on ice for 10 min, and GTP (0.4 mM) was added to the mixture.
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PMC9429973
Summary/Conclusion: Neutropenia is a group of conditions with different etiology and pathogenesis.
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PMC11285179
To further explore the regulatory mechanism of ANGPT1 expression, we identified a significant increase in the transcription factor RXRa and RARα after CCL28 stimulation in transcriptome data, verified by qPCR (Fig. 3D and E).
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PMC11539788
D-F) western blot analysis of phosphorylated AKT, mTOR, and S6K1 levels in BCa cells overexpressing ILK and quantitative analyses. (
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PMC10734950
We conducted three separate measurements and calculated the average and standard deviation, resulting in the determination of the percentages of both apoptotic and necrotic cells.
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PMC11723210
Quantitative phase imaging (QPI) offers a powerful solution by enabling non-invasive visualization of internal structures and refractive index distributions in transparent and semi-transparent samples, making it ideal for live-cell imaging applications .
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PMC11085211
The UHPLC-MS analysis was run on a Waters ACQUITY ARC UHPLC/MS system consisting of a QDa mass spectrometer equipped with an electrospray ionization interface and a 2489 UV–Vis detector.
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PMC11063646
Formulations using central composite design approach.
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PMC11021472
Two independent experiments were performed and based on the steepest decline in GFP competition assay, GFP + cells were sorted (> 98% purity) on day 5 (exp 1) or day 6 (exp 2) post-infection.
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PMC11474209
World Health Organization (WHO) found that the negative impacts of water pollution on human health account for 80 % of illnesses and 50 % of infant deaths worldwide.
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PMC11767582
Curiously, triazole 3j showed high selectivity for the colon cancer HT-29 cells (being the most active one for this cell line, with an IC50 value of 2 nM); however, it was much less cytotoxic for the lung cancer A-549 cell line (5.8 μM).
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PMC11597291
Support for the more efficient surface shielding by multi-armed PEG provides the relatively low PCT loading (11.2 %wt) reported by Xu et al. for graphene oxide particles functionalized with a 6-armed poly(ethylene glycol).
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PMC9429973
.
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PMC8584319
The precipitated formazan crystals were dissolved in DMSO, and absorbance was measured using a UVM340 plate reader (ASYS Hitech, Eugendorf, Austria) at a wavelength of 570/690 nm.
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PMC9429973
Aim 2 - Determine the prognostic significance of socioeconomic status on overall survival for patients with CLL.
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PMC9118379
The former peptide is indeed a variant peptide, but the latter peptide does not contain the variant site, and its identification cannot be used to support the identification of the S197R variant event because this peptide can come from peptide truncation or semitryptic digestion of a wild-type peptide.
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PMC11657695
Interestingly, after seven days of doxycyline treatment, no FLI1 peak was observed near the promoter of the F transcript (Day 7, Fig. 4B).
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PMC9429973
These scores are often based on dichotomized clinical predictors, leading to loss of information and thus inaccurate prognoses.
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PMC11467964
Similarly, we performed a colony formation assay on SW982 and SYO‐1 cell lines.
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PMC11190238
During neural crest migration, after progressing through a sequence of common transcriptional traits, a series of binary decisions are made to determine subsequent cell fates.
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PMC9429973
Patients with newly diagnosed DLBCL and ≥ 3 risk factors according to International Prognostic Index were treated according to “investigators decision” with 6-8 cycles of CHOP-like (1st group), R-CHOP (2nd group) or R-DA-EPOCH regimens (3rd group).
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PMC7153288
No microbial growth was detected on the SFM agar and the nutrient agar when the surface-sterilized stem sample was imprinted on these culture media.
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PMC3931643
As observed in the cap-binding assay, overexpression of 4EBP1 in OCI-LY7 did not alter the sensitivity to MLN0128.
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PMC7612475
B, Representative immunofluorescence staining of γH2AX-marked DNA damage in untreated U2OS cells depleted of SF3B1, and 1 and 24 hours following 2 Gy IR.
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PMC11049548
The extracellular amount of lactate was not significantly different among A2780, A2780cis, and HSGOC_T, even if slightly higher in HGSOC_T and A2780cis cells, whereas the intracellular concentration of lactate is higher in HGSOC_T (log2(FC) = 3.84), and A2780cis (log2(FC) = 3.81) cells then in A2780 cells (Figure 3C,D and Figure 5).
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PMC9429973
Selected transformed variables were picked and the potential overfit was avoided by a closed test procedure for function selection (Royston et al., John Wiley & Sons, 2008).
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PMC9046263
In addition, RNAseq reads were mapped to the human genome as opposed to the cell line genomes.
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PMC11082662
SMPDL3B as a novel diagnostic marker for ovarian cancer.
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PMC11040965
E Western blot and densitometric analysis of DNMT3B, with values normalized to β-actin and then to untreated cells.
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PMC11412721
However, a detailed phenotyping of Trp53 mice remained to be performed.
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PMC8922418
As some host factors are essential for the HIV-1 life cycle, they can be targeted to prevent HIV-1 infection.
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PMC11787355
The glioblastoma cell cluster expressed high levels of PTPRZ1 (Fig. 6b).
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PMC7369657
The expression of PARP-1 in the CQDs group was higher than the control group.
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PMC10213179
This strategy leverages the strengths associated with each SELEX process to identify aptamers that recognize a target protein in its endogenous conformation with high affinity and offers an alternative to Toggle SELEX, Hybrid SELEX, and Ligand Guided Selection SELEX.
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PMC11791478
Importantly, 25A3 demonstrated no interference with the coagulation process, as confirmed by assays evaluating FVII binding competition, FXa conversion, and thrombin generation.
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PMC9429973
Aims: To evaluate the renal response, hematological response and safety of pomalidomide in combination with bortezomib and dexamethasone (PVD) as first-line therapy in newly diagnosed MM (NDMM) with RI.
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PMC11705862
Our immunofluorescent staining of brain sections did not provide evidence for microglial expression of IRIS-1 and IRIS-2 as only very few or no IRIS-1 or -2 puncta was found within Iba-1 positive microglia (Fig. 1C, D).
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PMC11395280
Moreover, we determined that transwell migration of CCRF-CEM cells to CCL19 (Figure 1C), but not CCL21 (Figure 1D) was inhibited in the presence of 100nM or 200nM CCL198-83.
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PMC10706275
The genomic DNA was then purified and verified via PCR.
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PMC10809689
Before GC analysis, the samples were made volatile by silyl reagents.
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PMC10877303
Among the three hit phytochemicals, Kihadanin B binds to 3CL through six non-bond interactions, three of which involve the residues Glu169, Met168, and Cys145 located in the active site of the 3CL of MERS-CoV. Robustaflavone is bound by seven non-bond interactions, four of which involve the residues Gln192, Ala171, Cys145, and Met168, located in the 3CL active site.
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PMC11635519
HEK293 cells were maintained in DMEM (Sigma) supplemented with 10% FBS and 1% penicilin/streptomycin/glutamine and the appropriate selection antibiotics when required.
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PMC11740907
Pharmacological tests show polyoxometalate-loaded nanoparticles’ cancer therapy effectiveness and therapeutic potential.
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PMC11697065
C3 is involved in complementary pathway and fatty acid metabolism and was shown to be downregulated in CHO subcloning processes .
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