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OTAR3088
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BioData-CellLine_annotated

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PMC11397654
The proapoptotic, concentration-dependent effect of the CPT-50 micelles was further confirmed by annexin-FITC/PI staining.
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PMC9000591
On the other hand, the variations in the biological activities and amount of candidate compounds in the digestive system should be considered to ensure their bioaccessibility and bioavailability in the body .
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PMC9545474
Each experiment was repeated in triplicates of triplicates and a mean value was obtained and stated as IC50 (μM) ± SD.
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PMC11777207
Number of LPS-stimulated GM-CSF BMDCs (200 ng/ml) migrated across a transwell membrane to CCL21 (1 μg/ml) after 4 hours in the presence of blocking antibodies (200 μg/ml). (
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PMC10587429
In the current protocol, 3- to 4-week-old NSG-SGM3 mice are subjected to whole body sublethal irradiation 24 hours prior to the intravenous injection of fresh cord blood derived CD34+ HSCs.
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PMC5363531
Cells were grown in monolayer cultures in RPMI 1640 containing 10% fetal bovine serum, 2 mM glutamine, and 5% Penicillin/Streptomycin at 37°C humidified atmosphere of 95% air and 5% CO2.
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PMC9429973
This compares with 63% in 54 evaluable patients with DAGO only.
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PMC11733919
Therefore, more studies on senolytic design and testing are needed to improve the specific targeting of senescent cells in order to decrease the side effects.
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PMC9429973
Patients received age/risk-adjusted intrathecal therapy.
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PMC11365427
Heatmap of differential genes in the cell apoptosis pathway in NCI-H929 cells after 48 h of phenylalanine deprivation. (
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PMC11486946
Accumulating evidence shows that EGFR undergoes structural changes during its phosphorylation upon EGF stimulation and then translocates to a confined membrane region via interactions with membrane components (lipid, proteins, etc.),
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PMC9918897
Based on the recommendations for use and storage of XN , the drinking samples were replaced daily by fresh solutions.
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PMC8041314
C@PA included basic scaffold identification, substructure search and statistical distribution, as well as novel scaffold extraction to screen a large virtual compound library.
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PMC11248911
The cells were grown at 37 °C in a humidified atmosphere of 5% CO2.
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PMC11506827
Recently, cancer treatment research has expanded across various fields, including targeted chemotherapy using nanotechnology and biomaterials .
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PMC11676674
For genotoxicity assessment, 20 g of frozen leaf powder of C. monspeliensis leaves was extracted with methanol at 1:10 (w/v) in closed glass bottles by stirring with a magnetic stirrer for 48 h at room temperature.
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PMC10847511
The HRD score quantifies the characteristic chromosomal structural changes based on the SNP array data (see methods).
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PMC11742290
Zhang et.
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PMC11314247
VPA and DMSO exhibited similar cell viability in MDA-MB-231 cells (Table 1).
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PMC10604092
Furthermore, hypercalcemia, observed in the SLC-transplanted rats, is a common paraneoplastic symptom and is induced by PTHrP. As studies have reported that PTHrP is a causative factor of cancer cachexia, we measured the PTHrP level in the rats’ blood samples .
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PMC8010066
Besides, determining the physiological differences between biofilm and planktonic cultures is critical for understanding P. aeruginosa infections (such as those found in the cystic fibrosis lung) or removing problematic biofilms from tissue infections.
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PMC11574271
All experiments above were repeated three times (n = 3).
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PMC11794588
Previously it has been reported from different plants like Derris scandens, Albizia procera, and Diospyros rhodocalyx.
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PMC11012012
SLAMF3/CD229 was identified as a promising independent prognostic proteomic marker in patients treated for CLL.
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PMC8557138
Thus, bioprinting combined with appropriate bioink compositions as well as suitable cells or cellular spheroids holds the potential to develop functional tumor vascular grafts for disease modeling purposes.
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PMC9429973
In the ELEVATE -TN study the comparator arm included the combination of chlorambucil and obinutuzumab.
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PMC6102174
Especially, isovitexin (113) exhibited significant activity inhibiting HBV DNA replication with an IC50 value of 0.05 (SI = 19.8) mM, and the secretion of HBeAg with an IC50 values of 0.23 (SI = 4.3) mM .
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PMC11569208
.
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PMC11779993
Meanwhile, SPEE at concentrations of 50 and 100 μg/mL significantly upregulated the level of collagen type I (1.70 ± 0.16 and 5.28 ± 0.91) and elastin (1.96 ± 0.37 and 3.98 ± 0.59) expression (Figure 6(b)).
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PMC11640247
Pathogenic variants in RAC3, all of which reported thus far affect conserved residues within its functional domains, have been linked to neurodevelopmental disorders characterized by diverse phenotypic features, including structural brain anomalies and facial dysmorphism (NEDBAF).
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PMC11588085
This result is consistent with the RNA-seq data, where GSEA showed an overall downregulation of apoptotic genes indicating less cell death under hypoxia in OVCAR3-KRAB with XIST KD (Fig. 5H).
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PMC8345486
ACROS Organics: tert-butylchlorodimethylsilane 98%, sodium hydride 60% dispersion in mineral oil, and 1,4-dioxane 99.8% extra dry were purchased from Thermo Fisher Scientific (Waltham, MA, USA).
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PMC5308810
CXCR4 exhibits the similar cell proliferation rate. (
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PMC11512230
Multiplex PCR of 22 loci with STR repeats (SBT-RealGene SCREEN, SystemBiotech, Moscow, Russia) was used to authenticate the cell cultures.
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PMC11406030
Furthermore, in vivo safety studies showed no signs of toxicity after LMTK3BP treatment, even at doses as high as 40 mg/kg.
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PMC11711127
For example, differentiation from single positive thymocyte to naive T cell is accompanied by down-regulation of miR-181a, which results in upregulation of a multiple negative regulators of signalling that reduce the naive T cell’s sensitivity to pMHC (25).
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PMC10198699
As such, users of the SA MTA are free to change any of the substantive provisions of the SA MTA as they wish—as long as the main headings are retained in some form.
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PMC9429973
Patient characteristics are summarized in the Table.
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PMC11045125
A LMP1-expressing lentiviral vector was constructed by inserting the B95.8 EBV strain LMP1 gene into the pCDH-MSCV-MCS-EF1a-GFP-Puro vector (CD713-LMP1).
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PMC11541241
Genome database: Bc: http://fungi.ensembl.org/Botrytis_cinerea/Info/Index; Bgt: https://fungi.ensembl.org/Blumeria_graminis_f_sp_tritici_gca_900519115/Info/Index; Cg: https://fungi.ensembl.org/Colletotrichum_graminicola/Info/Index; Fg: https://fungi.ensembl.org/Fusarium_graminearum_ph_1_gca_000240135/Info/Index; Fo: http://fungi.ensembl.org/Fusarium_oxysporum/Info/Index?db=core; Mo: https://fungi.ensembl.org/Magnaporthe_oryzae/Info/Index; Pi: https://www.ncbi.nlm.nih.gov/bioproject/17665; Pst: https://fungi.ensembl.org/Puccinia_striiformis_f_sp_tritici_pst_78_gca_001191645/Info/Index; Vd: https://fungi.ensembl.org/Verticillium_dahliaejr2/Info/Index; Um: https://fungi.ensembl.org/Ustilago_maydis/Info/Index.
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PMC9516401
D: Dose-dependent effects of HEA.
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PMC11783017
After subcutaneous implantation for 7 days, obvious degradation was observed and the residual content of Cis/Mn/NH@PGP hydrogel was 42.7 ± 3.1 %, demonstrating its degradable property (Fig. S24).
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PMC8806312
To identify key immunity genes for OS, we screened DIRGs, and four key prognostic IRGs were identified, all of which may play a crucial role in OS and could be potential therapeutic targets.
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PMC11720808
Data are expressed as the mean ± SD (n=5).
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PMC11295144
Blots are representative of N = 2 independent experiments for each experimental paradigm.
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PMC11612315
Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, **p < 0.01, compared with the Sham + Vehicle group; p < 0.0001, compared with the SNI + Vehicle group).
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PMC8540692
The PAMPA set consists of donor and acceptor plates, separated by a 120 μm-thick microfilter disc coated with a 20% (w/v) dodecane solution of a lecithin mixture (Pion Inc., Billerica, MA, USA).
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PMC11286266
BLI studies were undertaken using on the Octet RED96 System (Pall FortéBio) using ATF6α_LD variants as biotinylated ligands that were immobilised on streptavidin (SA)-coated biosensors (Pall FortéBio) and rat calreticulin (rCRT) as the analyte.
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PMC11583690
This can be explained by the fact that free DTX exists in solution form with a release rate considered to be absolute (100 %), unlike DTX in BPMO@DTX, which exhibits a slower release rate due to the obstruction by BPMO nanoparticles during the release process (Fig. 5).
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PMC11705484
Cell colonies were fixed by crystal violet, and the number of colonies was counted. (
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PMC9429973
This abstract is an encore from the Society of Hematologic Oncology 2021 Annual Meeting.
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PMC11552389
The expression of FOXN3 was compared in tumor and normal tissues paired in the GEPIA database. (
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PMC9429973
All pts received FEDR 400 mg/d in continuous 28-d cycles.
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PMC10253973
ions can exploit the transferrin overexpression in the cancer cells by mimicking Fe(III) ions and binding to the protein.
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PMC11301095
Contact with contaminated water sources through the sinuses is the most common route of infection, leading to purulent hemorrhagic inflammation and necrotic changes in the olfactory bulb and extensive brain tissue, causing damage to central nervous system tissues .
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PMC9429973
L. Huang, J. Li, J. Yang, X. Zhang, M. Zhang, J. He, G. Zhang, Y. Su, W. Li, H. Wang, P. Lu Tsinghua University School of Medicine-Lu Daopei Institute of Hematology, Beijing; Hebei Yanda Lu Daopei Hospital,.,
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PMC11513011
The dosages are well tolerated by host animals.
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PMC11525028
Scale bars: 50 μm (left), 25 μm (right).
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PMC8316344
TRIB2-sg resistant TRIB2 was also simultaneously overexpressed in TRIB2 Bel-7404 cells for the rescue experiments.
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PMC9429973
Several ongoing clinical trials and further development of different drug formats will lead to a substanially increased number of eligibile patients and a broader application in the near future.
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PMC9429973
In the group of patients without FII and FV gene mutations, the frequency of the VKORC1 -1639AA genotype was almost equal to that in CG (17.1% vs. 16.5%, respectively).
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PMC11714165
A biochemistry analyzer (Chemray‐800, Rayto, China) was used to evaluate liver and kidney function.
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PMC11739670
Considering that CD8 binding contributes to the overall avidity of the tripartite complex during pMHCI engagement, it follows that the affinity of CD8 for different MHCI alleles may influence the affinity of the TCRs selected, depending on which allele/s they engage during thymic selection.
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PMC11676674
Absorbance was measured at 570 nm after a further 4 h of incubation, when the formazan crystals produced in the MTT reaction were solubilized in DMSO.
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PMC10605143
We studied the HSF1 influence on the phenotype of non-tumorigenic human mammary epithelial (MCF10A and MCF12A) and several triple-negative breast cancer cell lines.
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PMC11271278
Source data are provided as a Source Data file.
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PMC7553912
The boxed regions are shown at a higher magnification in the insets.
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PMC11496728
Fig. 7Comparison of transient and stable expression levels and relative copy number of SEAP in CHO-WT and CHO-KO cells.
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PMC11637276
We also observed differences in the invasive front morphology, where MAP3K1 knockdown resulted in shorter and thicker multicellular strands protruding from the spheroid core (Fig 6B and 6E).
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PMC11721295
In summary, we demonstrate that induction of KRAS and co-occurring mutant p53 expression in the lung produces highly proliferative lung tumors that can be reduced by abrogating KRAS expression, genetically or chemically, resulting in fewer pulmonary lesions, likely due to apoptotic cell death of tumor cells.
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PMC9429973
Some of these mutations are acquired in a preleukemic state termed clonal hematopoiesis of indeterminate potential (CHIP).
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PMC8956657
Twenty-four hours post-transfection, cells were treated with 50 ng/ml of TNFα (PeproTech, cat# 300-01 A) for 18 h. Luciferase activity was assessed and analyzed as described above.
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PMC11587606
The statistical analysis of fluorescence density of RHBDF1 and PKCζ in (B). (
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PMC11045125
To examine whether Myc repression of LMP1 expression might also be mediated via enhanced DNA methylation of the LMP1 promoters, cell lines derived from the ΔEBNA2 + Myc lymphomas were treated with or without the demethylating agent, 5-azacitadine, and the levels of LMP1 expression were examined by immunoblot analysis (Fig 9E).
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PMC11055323
d Histogram shows the ratio of EdU positive cells in (c).
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PMC9429973
Patients were excluded if they were <18 years old or had a history of lymphoma.
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PMC9429973
The number of patients in bleeding group who received bridging therapy before CAR-T were significantly more than those in non-bleeding group (10/11, 90.9% vs. 6/15, 40%) (P=0.0259).
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PMC11591030
However, the gene expression of these factors in the LPS + ML385 treatment group remained significantly elevated, indicating that blocking the Nrf2/Keap1 signaling pathway does not affect the expression of the NF-κB signaling pathway.
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PMC11679892
The concentration calculation was analyzed according to Figure 2 and this value was determined as 1.1397 ng/mL in the control group, while this value was determined as 1.4815 ng/mL in the extract dose group (p < 0.05) (Figure 2).
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PMC11791264
Accordingly, SETD7 OE-induced promotion of cell proliferation was rescued by the K51M mutant (Fig. 4, G and H).
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PMC11666785
IML-SPIM has enabled super-resolution imaging of human mammary MCF10A cell spheroids expressing H2B-PAmCherry.
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PMC7192625
Analysis of the assortativity of epigenomic features in primary neutrophils. (
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PMC11676169
The lysates were cleared by centrifugation at 14,000× g for 30 min.
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PMC11711063
Relative kinase phosphorylation levels normalized to total amounts are shown in heatmaps.
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PMC9429973
Results: Prior to study entry, 31% (n=25) of PEGASUS patients (6 of these while on ECU therapy) and 9% (n=5) of PRINCE patients experienced at least one type of thrombosis.
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PMC11047729
Calcitriol is an active form of vitamin D that can be synthesized in the human body through a series of changes, as shown in Figure 7.
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PMC6835428
In the case of IV administration, it is known that particles of 1–3 μm diameter tend to localize closer to the endothelial layer (margination effect) of the vessel, whereas smaller particles localize to the middle of the vessel .
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PMC6267596
We surmise that these up-regulated proteins may provide DIAP cells with the ability to divide either by multipolar mitosis, meiosis-like division, or budding type division (Figure 6d).
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PMC11064533
The procedure was the same for each cell line, whereby unattached bacteria in the supernatant were collected, the adhered bacterial cells were carefully removed by pipetting, and the resultant fluid from both was subjected to RNA isolation by the RNAsnap method (18).
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PMC11696659
A control group (N = 453) included individuals of similar age with COPD or healthy.
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PMC11786600
Figure 1Process demonstration images of portable electrospinning. (
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PMC6102174
9Structures of compounds 138–150 Structures of compounds 138–150 Illicium henryi (Honghuixiang) is a shrub distributed in the southwestern part of China, and its bark and roots have been used as a folk-medicinal herb for dispelling wind-evil and assuaging pain.
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PMC11791203
Log Po/w - Lipophilicity (acceptable range: <5).
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PMC11694625
Chromatographic conditions: run time: 6 min; column temperature: 40 °C; injection volume: 5 μL. Chromatographic column: C18, 2.7 μm, 3.0 × 75 mm.
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PMC11394730
Because of this, squelching free radicals is a tactic to stop the formation of tumors, as they are involved in cancer development .
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PMC11301242
In hematological cancers, research on ecDNA has been primarily confined to case reports, case series, and small cohort studies of specific diseases, such as lymphoma and acute leukemia [, , , , ].
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PMC11787381
After surgery, mice were allowed to recover before getting back in their cage.
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PMC9429973
Importantly, low NR4A1 expression correlated with high expression of immune checkpoint components in biopsies of our human DLBCL cohort largely resembling our mouse data.
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PMC10919056
Combined with the GSE29609 dataset, a training set and a testing set of TSs were constructed to assess the prognostic significance of the GRPS in ccRCC.
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PMC11594806
These findings suggest that reduced mitochondrial numbers contribute to the progression of human OS, and that enhancing mitochondrial biogenesis with AICAR through AMPK activation exerts anticancer effects on human OS by promoting mitochondrial proliferation and apoptosis .
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