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PMC11012313
Since mTOR and STAT3 are constitutively active in numerous human cancers, pharmacological inhibition of these pathways are a very active area of clinical research and may be especially important in the treatment of EBV-associated lymphomas.
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PMC2944824
The objective of the study was to determine the involvement of Hr in apoptosis in the brain.
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PMC9429973
A. Petrenko, M. Kislova, E. Dmitrieva, T. Novikova, M. Kislitsyna, T. Obukhova, E. Nikitin, V. Ptushkin Moscow City Center of Hematology, Botkin hospital; Russian Medical Academy of Continuous Medical Education; Karyology laboratory, National Medical Research Center for Hematology, Moscow, Russia Background: In the largest study of Baliakas et al. (2019) the presence of at least 5 abnormalities, was associated with dismal clinical outcome, independently of the somatic hypermutation status and TP53 status.
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PMC10969097
The expression levels of protein kinase B (Akt) and p-ERK1/2 were significantly reduced in cells treated with grifolin, suggesting that the main mechanism underlying the action of this compound on A2780 cells occurred via the Akt and ERK1/2 signalling pathways .
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PMC11420784
Supplementary materials are available at The Journal of Infectious Diseases online (http://jid.oxfordjournals.org/).
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PMC9429973
Image: Summary/Conclusion: New treatments have been incorporated into the therapeutic scenario of TNE-NDMM in the last years.
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PMC9429973
In a large randomized trial, convalescent plasma obtained from persons recovering from the infection was not proven to be useful in treatment of COVID19 in the general population, but other studies suggest it is useful in hematologic patients unable to produce antibodies against the virus.
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PMC5941560
Structural variant calls from each tool were separated by class for further analyses.
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PMC9429973
In all patients the occurrence of ATE (e.g. a heart attack, a stroke, critical limb ischemia) was assessed during the active treatment and the three months following the last chemotherapy session.
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PMC11171319
Similar to the dedifferentiation of mature HMEC infected with HCMV-DB and BL strains, we observed dedifferentiation of mature ovarian epithelial cells and prostate epithelial cells into immature progenitor cells with stemness traits .
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PMC9429973
In non-splenectomized SCA-children, mean (SD) HJB scores were unexpectedly significantly higher (P<0.001) in patients on HU 1.39 (0.91) than in not-intensified 1.11 (0.82), in those on CT 1.09 (0.86) and in transplanted children 0.35 (0.7) (Figure 4).
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PMC11703992
Instrumental variants with low F-statistics were considered weak instruments and deleted. (
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PMC9352806
Fig. 4Impacts of BMS on the daf-16/hlh-30 mediated lipophagy pathway.
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PMC11473843
Therefore, the identification of mechanisms by which cancer cells evade treatment in mutant KRAS-driven tumors is of paramount importance.
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PMC10854447
According to these results, the examined compounds 7j, 7k, and 7l may have apoptotic potential activity, which may account for their antiproliferative effects.
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PMC9429973
In patients with BMHF, HLH-2004 criteria discriminated best between patients with poor and favourable OS than HLH-2009 (C-index 0.6364 vs 0.5601; AIC 400.24 vs 411.53).
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PMC10854447
Calc. (%)
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PMC6160470
DAC compounds effectively inhibited viability of both cell lines.
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PMC11049294
Imaging flow cytometry was performed on an ImageStreamX Mark II operated by INSPIRE software (version 201.1.0.765, Amnis Corporation, Seattle, WA, USA).
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PMC11680578
Noteworthy findings from our current research reveal reduced levels of cancer stemness genes NANOG, OCT4, and EHF in synergistic treatment.
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PMC11672617
Furthermore, this process has the potential to stimulate the formation of a range of free radicals and other oxidative radicals through the mitochondria, which can then lead to the activation of caspases and the induction of apoptosis.
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PMC11770130
The UPR, as a part of the integrative stress response, may affect the production of growth differentiation factor 15 (GDF15), a secretory protein.
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PMC11209164
The cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM), sourced from either HyClone (Waltham, MA, USA) or Corning (Manassas, VA, USA).
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PMC11679033
The donor was familiar with the details of the research and gave informed consent to voluntary participation.
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PMC11765879
Moreover, several investigations reported the potential use of ZSC in the treatment of several diseases including cancer .
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PMC11700340
It demonstrated that the cancer cells’ growth suppression depended on the duration of their exposure to linagliptin and the drug’s concentration.
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PMC11471176
These are ELISA kits which operate by utilizing the Sandwich-ELISA method, employing a Micro Elisa strip plate precoated with antibodies specific to ACE2.
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PMC11323699
Tumor patients having the highest CD47 expression profile at baseline showed the greatest CD4 and CD8 T-cell influx post NACT and displayed a better prognosis.
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PMC10587429
Penicillin-Streptomycin-Glutamine (10378016, Thermo Fisher Scientific, Waltham, MA). -
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PMC9621239
The Hoechst stain with blue fluorescence was used to label the general DNAs.
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PMC11670954
Finally, we recommend adopting more precise and versatile molecular research methods to investigate BA’s direct effects on the RhoA/ROCK2/MLCK signaling pathway.
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PMC11082662
On the first day posttransfection, a 10-µL aliquot of medium and 10 µL of CCK-8 mixture were added to the transfected cells, which were then incubated for 1 hour at 37 ℃.
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PMC11585565
To assess Mg export activity, Magnesium Green, a fluorescent indicator for Mg, was incubated with the transfected HEK293 cells and the Mg efflux assay was conducted 24-hours post-transfection (Fig. 2a).
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PMC11365983
Bar plots show mean values ± SEM.
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PMC8567602
Again, we noted a faint SMARCB1-staining band, running at larger size than 47 kDa in the monomer-sized fractions, possibly indicating SMARCB1 ubiquitylation during incorporation with SS18–SSX in CBAF complexes.
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PMC5925824
The paucity of information is related at least in part to the relatively recent availability of humanized murine tumor models with reconstituted human immune cell compartment(s).
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PMC10965315
According to ProTox‐II, harmaline has been categorized as toxicity class‐4, which means that it is considered to have low toxicity.
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PMC11769522
Similarly, in this study, a single treatment with either IFN-γ or TNF-α induced significant increases in CCL2 concentrations; however, the IFN-γ/TNF-α mixture synergistically enhanced CCL2 production compared to single treatments.
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PMC11172027
It is assumed that cancer cells, which require a high level of energy, also make significant use of the radical mechanism for growth and final differentiation and may also be involved in tumor development and that selenium containing substances is involved in non-apoptosis regulations.
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PMC10998613
After incubation for 2 d, the cells were treated with agonists for 6 h at 37 °C.
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PMC10033453
Liver function tests were performed on serum samples collected from terminal bleeds for albumin (ALB), aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, and glucose (GLU) (Figure 3C).
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PMC11525293
C ACE2 mRNA levels were evaluated by qRT-PCR, and mRNA levels were normalized using GAPDH as housekeeping gene.
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PMC11487720
The first bubbling at 22 min was prolonged to approximately 48 min at 22 °C (Fig. 3D).
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PMC10605143
They can differentiate into either ductal cells or milk-producing cells.
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PMC9599726
IHC slides were observed on a AxioObserver Z1 inverted microscope (Zeiss, Jena, Germany), using a Plan Apochromat 20x/0.8 dry objective (Zeiss).
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PMC11536589
The protein levels were quantified using ImageJ software.
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PMC11706776
D Western blots of SK1 and EWS::FLI1 in A-673, RD-ES and SK-ES-1 cell lines after 72 h of transient transfection with a pool of siRNA targeting EWS::FLI1 (siRNA EWS::FLI1) or a siRNA control (siRNA CT) (N = 2) (lower panels).
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PMC11363012
Colors of the data points represent the class of metabolites.
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PMC9429973
About half of the pts who discontinued dasatinib maintained TFR at 5 y. Re-treatment after relapse was successful; all evaluable pts who lost MMR regained MMR and MR after therapy was reinitiated.
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PMC9429973
The median time to first SVR35 was 12.1 (range, 11 to 47) weeks.
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PMC11078693
Pick up the glass with forceps/tweezers (Figure 1, problem 2).e.
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PMC11453018
This modification is essential for cancer progression in various types such as liver cancer, prostate cancer, melanoma, renal carcinoma, leukemia, lymphoma, and lung cancer .
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PMC9739791
Furthermore, under irradiation, Rhodaplatins 15 and 16 were up to 10-fold more active than their corresponding Pt(II) drugs: rhodaplatin 16 showed 9.8-fold lower IC50 values on the A2780cisR cell line than oxaliplatin under irradiation.
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PMC11694066
We next compared R-loop levels in cells exposed to PARPi, ATRi, or their combination in the presence or absence of EWS–WT1 silencing.
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PMC11575040
Hence, melanomas depend on OXPHOS, and they can adapt to changes in metabolism .
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PMC11525028
Representative H&E images showing lung metastasis nodules of the mouse model.
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PMC9429973
Half of the population had grade 3 or higher of mucositis, nearly two-third of patients had more than 39°C of body temperature at least once, and median peak number of daily fever spikes was three (range 1-5).
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PMC11564322
Two-step real-time RT-PCR was conducted using the CFX Real Time System (BioRad, USA).
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PMC11285179
These results suggested that CCL28 could promote vascular normalization and mobilize pericytes.
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PMC7802142
After staining by DAPI (Sigma, USA), the cells were imaged by fluorescence microscope with a 20× objective (Nikon).
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PMC11760643
Whether CDC can be mediated by a P2X7 biologic has not been reported.
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PMC11612626
MMCLs were treated for 48 hours with compound A (1 μmol/L), after which cells were PBS washed twice, resuspended in FACS buffer, and probed with antibodies to the following: HLA-ABC (W6/32), recombinant Alexa Fluor 647–conjugated anti–HLA-A (Abcam, ab199837), HLA-B (Invitrogen, PA5-35345), and Alexa Fluor 647–conjugated anti–human HLA-C (BioLegend, 373308).
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PMC11803149
Importantly, Epas1 deficiency restricts the capacity of young CD8 T cells to accumulate as Tpex-like cells in tumors, so as to control tumor growth.
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PMC4659567
The in vitro cytotoxicity towards human ovarian carcinoma A2780 (ECACC No. 93112519) was tested by an MTT assay evaluated spectrophotometrically at 540 nm (TECAN, Schoeller Instruments LLC).
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PMC9621239
Figure 3.HBx-T81P/S101P/L123S upregulates the level of MYC compared with wild-type HBx (A) Protein dockings between wild-type HBx and MYC or between mutant HBx and MYC were predicted in silico.
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PMC10253553
Given that Torin 2 is a potent inhibitor of both mTORC1 and mTORC2 that completely ablates the phosphorylation of NDRG1 (Thr346) (Figure 3), and that phospho-NDRG1 (Thr346) is resistant to rapamycin at all concentrations tested (Figure 4), these data indicate that mTOR in complex 2, but not complex 1, mediates the phosphorylation of NDRG1 (on Thr346) in ccRCC cells.
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PMC11670407
Finally, the KO monoclonal cell lines were progressively expanded in culture.
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PMC11314247
In this work, we explored the type of cell death caused by HO-AAVPA over short- and long-term treatment, alongside its effect on the cell cycle and GPER expression, which is associated with cell apoptosis and proliferation.
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PMC9429973
P. Xu, Z. Shi, L. Wang, S. Cheng, W. Zhao Shanghai Institute of Hematology; National Research Center for Translational Medicine at Shanghai; Ruijin Hospital; Shanghai Jiao Tong University School of Medicine; Pôle de Recherches Sino-Français en Science du Vivant et Génomique, Shanghai, China Background: The optimal treatment for elderly diffuse large B-cell lymphoma (DLBCL) patients needs to be further explored due to their comorbidities, intolerability of standard immunochemotherapy, and unfavorable genetic features.
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PMC11748335
Intriguingly, when comparing tumor cell lines against normal counterparts, an increased enrichment in common PMDs was observed, accompanied with a decreased enrichment in common HMDs.
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PMC8469018
Surprisingly, the results of mitochondrial membrane potential assay and level of cellular thiols indicate mitochondria-independent apoptosis due treatment with teriflunomide for 24 h in RPMI 8226 cells.
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PMC11758416
Follow steps detailed in above L cell culturing section 2a-j.b.
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PMC11802929
Created in BioRender.
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PMC11180402
and ♣ indicate significant differences among corresponding groups (p < 0.05) ISO inhibited invasion and anchorage-independent growth of human BMIBC cells via SNHG1 downregulation.
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PMC11422497
Moreover, miR-494-3p expression was found to be significantly and negatively regulated by circ_SMA4 expression in GIST-T1 and GIST-882 cells (P < 0.05; Fig. 3G).
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PMC10878518
Histological diversity and tumor heterogeneity lead to the lack of common molecular targets for treating patients with bone and soft-tissue sarcomas.
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PMC11621493
3PLA2G4D acylates mono- and diacylglycerol. (
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PMC11705547
Nevertheless, the common side effects of cisplatin, including nephrotoxicity, ototoxicity, hepatotoxicity, cardiotoxicity and neurotoxicity, limit its dosage and frequency of use.
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PMC7171147
d Western blot of pSrc (Y416) and CPT1A in ES2 cells cultured in either PBS or COL11A1-coated plates for 48 h and treated with Dasatinib (2 µM) for 48 h. GAPDH was used as a loading control.
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PMC11742670
The effect of Vidarabine against different cancer cell lines is calculated by the determination of IC50.
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PMC10203589
FGF18 can first bind to FGFR2 and FGFR3, and then promote the viability of ishikawa cells by enhancing the phosphorylation levels of AKT and ERK downstream, and the activation of Survivin and CD44V6 expression is closely related to the FGFR/FGFR3 pathway of FGF18 (143).
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PMC11320084
In addition to being involved in embryogenesis, organ development and tissue formation, EMT also participates in genesis and metastasis of tumors and promotes invasion and movement of tumor cells.
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PMC9429973
D. Feng, E. Jiang Hematological Hospital, Chinese Academy of Medical Sciences, Hematological Hospital, Chinese Academy of Medical Sciences, Tianjin, China Background: Although not yet included in guidelines, TP53 mutations are undoubtedly one of the undesirable factors in the risk prognosis of medullary tumors in the hematologic system.
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PMC11511922
Exosomes (EVs) were labeled with PHK67 (green) and the DNA (blue).
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PMC5839394
Where not expressed, the cells were treated with the corresponding IC50 values.
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PMC11412721
We also analyzed dataset #GSE181063 (Lacy et al., 2020), comprising mostly diffuse large B-cell lymphomas (DLBCL; 613 men, 536 women) and a few Burkitt lymphomas (65 men, 18 women).
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PMC11724582
These findings suggest that the mechanism by which CAFs induce almonertinib resistance may be related to YAP/TAZ.
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PMC9119314
Seven-point potency curves were performed in 96-well microliter plates (200 μL volumes), and the compound concentrations that inhibited growth by 50% (IC50) and 90% (IC90) were determined.
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PMC11574271
Outcomes from these studies should help us not only understand the biology of bladder cancer pathogenesis but also facilitate the identification of novel therapeutic targets for the development of effective therapeutics to combat this malignant disease.
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PMC11701801
Mice were checked for clinical indications, tumor size, and body weight as specified in the experimental licenses.
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PMC11731614
Primary keratinocyte cultures.
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PMC11533140
The reactions were monitored by thin-layer chromatography (TLC) on precoated silica GF254 plates.
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PMC11766350
4 mL of each culture were collected and centrifuged at 16,000× g, 20 min, 4 °C.
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PMC11773391
But the exact mechanism has not been elaborated.
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PMC10253973
The drug combinations with synergistic potential were developed by Sava et al. through the use of high-throughput screening .
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PMC9429973
Aims: We aimed to assess the basal metabolic characteristics in MDS-derived MSCs and the effect of Epo on their energetic profile in vitro.
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PMC10938377
Much recent work has focused on finding more site selective metallocompounds, and we earlier discovered that RAPTA [(arene)Ru(1,3,5-triaza-7-phosphaadamantane)Cl2] anti-metastasis/tumor drugs and RAPTA-like agents have a preference for binding to defined histone protein sites, as opposed to the DNA, of chromatin.
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PMC10944868
Firstly, selective cytotoxicity was observed in SKOV3 and BT20 cell lines, where most of the compounds showed cytotoxicity.
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PMC10728200
GIST-T1 and 882 cells were treated with IM (50 nM for T1 and 200 nM for 882) or a control vehicle for 24 h and then incubated with the anti-STUB1 and anti-GPX4 antibodies and detected by DuoLink probe (Olink Bioscience, Uppsala, Sweden).
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PMC11591038
Under high-glucose condition, BACE1 is upregulated with increased Aβ production through HIF-1α activation and decreased LXRα expression via the JNK pathway in a ROS-dependent manner in SK-N-MC, a neuroblastoma cell line .
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