Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC4695073
The relative resistance factor (RRF) was calculated by dividing the IC50 value by that of control group.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "resistance", "factor", "(", "RRF", ")", "was", "calculated", "by", "dividing", "the", "IC50", "value", "by", "that", "of", "control", "group", "." ] } ]
PMC11684269
In the context of obesity, lupus mice exhibit exacerbated kidney damage (117).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "context", "of", "obesity", ",", "lupus", "mice", "exhibit", "exacerbated", "kidney", "damage", "(", "117", ")", "." ] } ]
PMC9429973
All three pts achieved CR by PET-CT at day 28 after GC012F infusion, and response is ongoing at 3-months follow-up in the two assessable patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "three", "pts", "achieved", "CR", "by", "PET-CT", "at", "day", "28", "after", "GC012F", "infusion", ",", "and", "response", "is", "ongoing", "at", "3-months", "follow-up", "in", "the", "two", "assessable", "patients", "." ] } ]
PMC5363531
After exposure of cell lines to drugs, an [3-(4-5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)- 2-(4-sulfophenyl)-2H-tetrazolium, inner salt MTS assay (Promega, Madison, USA) was performed according to the manufacturer's instruction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "exposure", "of", "cell", "lines", "to", "drugs", ",", "an", "[", "3-(4", "-", "5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-", "2-(4-sulfophenyl)-2H-tetrazolium", ",", "inner", "salt", "MTS", "assay", "(", "Promega", ",", "Madison", ",", "USA", ")", "was", "performed", "according", "to", "the", "manufacturer", "'s", "instruction", "." ] } ]
PMC11599565
The neuronal nature of these cells is confirmed by the expression of βIII-tubulin (F).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "neuronal", "nature", "of", "these", "cells", "is", "confirmed", "by", "the", "expression", "of", "βIII-tubulin", "(", "F", ")", "." ] } ]
PMC7351993
Chlamydomonas sp. KC4, a lipid-rich strain derived from Chlamydomonas sp. JSC4, was used as a patented strain for directed evolution or selective breeding of a super-lipid-rich mutant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chlamydomonas", "sp.", "KC4", ",", "a", "lipid-rich", "strain", "derived", "from", "Chlamydomonas", "sp.", "JSC4", ",", "was", "used", "as", "a", "patented", "strain", "for", "directed", "evolution", "or", "selective", "breeding", "of", "a", "super-lipid-rich", "mutant", "." ] } ]
PMC11706491
During G1, Cdt1 accumulates, staining cells red.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "G1", ",", "Cdt1", "accumulates", ",", "staining", "cells", "red", "." ] } ]
PMC9065483
The Indiana serotype of VSV harboring a deletion of methionine 51 in the M protein (VSVΔ51) and insertion of GFP or FLuc were used throughout this study.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Indiana", "serotype", "of", "VSV", "harboring", "a", "deletion", "of", "methionine", "51", "in", "the", "M", "protein", "(", "VSVΔ51", ")", "and", "insertion", "of", "GFP", "or", "FLuc", "were", "used", "throughout", "this", "study", "." ] } ]
PMC7342409
Secondary mutations of KIT/PDGFRA in GIST cells were the most important contributors to imatinib resistance in GISTs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "mutations", "of", "KIT/PDGFRA", "in", "GIST", "cells", "were", "the", "most", "important", "contributors", "to", "imatinib", "resistance", "in", "GISTs", "." ] } ]
PMC11487720
The Ras rescue-based CytoTrap yeast two-hybrid analysis (Stratagene, La Jolla, CA, USA) was carried out to map the binding of WWOX with TRAF2 [14–17].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Ras", "rescue-based", "CytoTrap", "yeast", "two-hybrid", "analysis", "(", "Stratagene", ",", "La", "Jolla", ",", "CA", ",", "USA", ")", "was", "carried", "out", "to", "map", "the", "binding", "of", "WWOX", "with", "TRAF2", "[", "14–17", "]", "." ] } ]
PMC10840195
A similar effect of Wnt inhibitors was observed in ovarian cancer cells, where inhibition of the Wnt pathway reveQpment of RCC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "effect", "of", "Wnt", "inhibitors", "was", "observed", "in", "ovarian", "cancer", "cells", ",", "where", "inhibition", "of", "the", "Wnt", "pathway", "reveQpment", "of", "RCC", "." ] } ]
PMC11746948
We found that treatment with 2-BP did not change the levels of these lipid species (Supplementary Fig. 3d, e).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "treatment", "with", "2-BP", "did", "not", "change", "the", "levels", "of", "these", "lipid", "species", "(", "Supplementary", "Fig.", "3d", ",", "e", ")", "." ] } ]
PMC11352311
Additionally, the antitumor activity of esculin has been the focus of considerable research.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "antitumor", "activity", "of", "esculin", "has", "been", "the", "focus", "of", "considerable", "research", "." ] } ]
PMC9436459
0.5 μg/mL (5-FU)HepG234.35 μM 41.55 μM (CUR)MCF-735.79 μM 34.17 μM (5-FU)Australisine A (113)A549n.a.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "0.5", "μg/mL", "(5-FU)HepG234.35", "μM", "41.55", "μM", "(CUR)MCF-735.79", "μM", "34.17", "μM", "(5-FU)Australisine", "A", "(113)A549n.a", "." ] } ]
PMC8164677
Our study points towards possible action of wedelolactone on these selected protein targets associated with resistance (Figures 6 and 11).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "points", "towards", "possible", "action", "of", "wedelolactone", "on", "these", "selected", "protein", "targets", "associated", "with", "resistance", "(", "Figures", "6", "and", "11", ")", "." ] } ]
PMC6617630
There are some DLBCLs in which MYC and BCL2 genes are overexpressed at the protein level, without genetic rearrangements.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "some", "DLBCLs", "in", "which", "MYC", "and", "BCL2", "genes", "are", "overexpressed", "at", "the", "protein", "level", ",", "without", "genetic", "rearrangements", "." ] } ]
PMC2118063
For sorting of EGFP and EGFP populations, cells were harvested and resuspended in RPMI medium (Life Technologies) supplemented with 200 U/ml penicillin G, 10 μg/ml gentamycin, and 10% FCS before using a cell sorter (MoFlo; DakoCytomation).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "sorting", "of", "EGFP", "and", "EGFP", "populations", ",", "cells", "were", "harvested", "and", "resuspended", "in", "RPMI", "medium", "(", "Life", "Technologies", ")", "supplemented", "with", "200", "U/ml", "penicillin", "G", ",", "10", "μg/ml", "gentamycin", ",", "and", "10", "%", "FCS", "before", "using", "a", "cell", "sorter", "(", "MoFlo", ";", "DakoCytomation", ")", "." ] } ]
PMC11604830
As the software available for MRI acquisition did not offer a CSI image analysis package, the multi‐voxel spectroscopic images were processed and analyzed using an in‐house script package running in Fiji/ImageJ software.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "the", "software", "available", "for", "MRI", "acquisition", "did", "not", "offer", "a", "CSI", "image", "analysis", "package", ",", "the", "multi‐voxel", "spectroscopic", "images", "were", "processed", "and", "analyzed", "using", "an", "in‐house", "script", "package", "running", "in", "Fiji/ImageJ", "software", "." ] } ]
PMC11244823
Based on these observations and in combination with the previous ELISA data, posC1 and posC2 were selected as positive controls, whereas No. 62 was confirmed as negative control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "observations", "and", "in", "combination", "with", "the", "previous", "ELISA", "data", ",", "posC1", "and", "posC2", "were", "selected", "as", "positive", "controls", ",", "whereas", "No.", "62", "was", "confirmed", "as", "negative", "control", "." ] } ]
PMC10890055
At elevated (restrictive) temperature, cells stop dividing and can differentiate into mature cell types .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "elevated", "(", "restrictive", ")", "temperature", ",", "cells", "stop", "dividing", "and", "can", "differentiate", "into", "mature", "cell", "types", "." ] } ]
PMC10956161
The exclusion criteria were as follows: (i) multiple epidermal growth factor receptor (EGFR) gene mutations; (ii) metastases from the primary lung tumour.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exclusion", "criteria", "were", "as", "follows", ":", "(", "i", ")", "multiple", "epidermal", "growth", "factor", "receptor", "(", "EGFR", ")", "gene", "mutations", ";", "(", "ii", ")", "metastases", "from", "the", "primary", "lung", "tumour", "." ] } ]
PMC11461874
In addition, the physiological role of D-box-dependent transcription has been studied using gene KO (knockout) strategy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "physiological", "role", "of", "D-box-dependent", "transcription", "has", "been", "studied", "using", "gene", "KO", "(", "knockout", ")", "strategy", "." ] } ]
PMC11144382
Increases in VCAM1 expression in macrophages, fibroblasts and endothelial cells have been reported in rheumatoid arthritis, while Vcam1 expression in murine osteoblasts is important for cellular adhesion and activation of osteoblasts to binding partners in bones, which are required for maintaining the signals regulating the balance between bone formation and bone resorption.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increases", "in", "VCAM1", "expression", "in", "macrophages", ",", "fibroblasts", "and", "endothelial", "cells", "have", "been", "reported", "in", "rheumatoid", "arthritis", ",", "while", "Vcam1", "expression", "in", "murine", "osteoblasts", "is", "important", "for", "cellular", "adhesion", "and", "activation", "of", "osteoblasts", "to", "binding", "partners", "in", "bones", ",", "which", "are", "required", "for", "maintaining", "the", "signals", "regulating", "the", "balance", "between", "bone", "formation", "and", "bone", "resorption", "." ] } ]
PMC11307990
A 5 μL sample solution was adsorbed on a freshly cleaved mica surface for 10 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "5", "μL", "sample", "solution", "was", "adsorbed", "on", "a", "freshly", "cleaved", "mica", "surface", "for", "10", "min", "." ] } ]
PMC11548041
Their sequences are reported in Table 2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "sequences", "are", "reported", "in", "Table", "2", "." ] } ]
PMC11297139
Scale bar: 5 μm.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "5", "μm", "." ] } ]
PMC11286266
Figure 2—figure supplement 1.ER-resident proteins (with a KDEL-COOH tag) in calreticulin (CRT)-depleted cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2—figure", "supplement", "1.ER-resident", "proteins", "(", "with", "a", "KDEL-COOH", "tag", ")", "in", "calreticulin", "(CRT)-depleted", "cells", "." ] } ]
PMC9019892
The assay was tested by flow cytometry (BD, San Jose, CA, USA) as published previously .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "was", "tested", "by", "flow", "cytometry", "(", "BD", ",", "San", "Jose", ",", "CA", ",", "USA", ")", "as", "published", "previously", "." ] } ]
PMC11594588
Each time such a disturbance of cellular homeostasis in the heart muscle occurs, it results in insufficient energy metabolism and cellular damage to cardiomyocytes .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "time", "such", "a", "disturbance", "of", "cellular", "homeostasis", "in", "the", "heart", "muscle", "occurs", ",", "it", "results", "in", "insufficient", "energy", "metabolism", "and", "cellular", "damage", "to", "cardiomyocytes", "." ] } ]
PMC11092382
Furthermore, sophocarpine dose-dependently inhibited the growth of the gastric cancer cell line MKN45 and BGC-823 by interrupting cell cycle progression, inhibiting proliferation and apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "sophocarpine", "dose-dependently", "inhibited", "the", "growth", "of", "the", "gastric", "cancer", "cell", "line", "MKN45", "and", "BGC-823", "by", "interrupting", "cell", "cycle", "progression", ",", "inhibiting", "proliferation", "and", "apoptosis", "." ] } ]
PMC11040965
U266 and RPMI 8226 cells were stimulated with anti-CD28-loaded particles and (A) cultured alone, in the presence of CD28-blocking antibody or the PI3K inhibitor (25 µM LY294002 48 h; 0.5 µM buparlisib 24 h), or (B) cultured alone, transfected with 10 µM miRNA mimic negative control (miR-NC) or miR29b mimic (miR29b).
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U266", "and", "RPMI", "8226", "cells", "were", "stimulated", "with", "anti-CD28-loaded", "particles", "and", "(", "A", ")", "cultured", "alone", ",", "in", "the", "presence", "of", "CD28-blocking", "antibody", "or", "the", "PI3", "K", "inhibitor", "(", "25", "µM", "LY294002", "48", "h", ";", "0.5", "µM", "buparlisib", "24", "h", ")", ",", "or", "(", "B", ")", "cultured", "alone", ",", "transfected", "with", "10", "µM", "miRNA", "mimic", "negative", "control", "(", "miR-NC", ")", "or", "miR29b", "mimic", "(", "miR29b", ")", "." ] } ]
PMC8973725
TMA construction was performed as Steurer S previously described .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TMA", "construction", "was", "performed", "as", "Steurer", "S", "previously", "described", "." ] } ]
PMC9275501
Secondly, although the combination of natural active ingredients and chemotherapy drugs can reduce the side effects of chemotherapy drugs by reducing the intake of chemotherapy drugs and directly acting on certain targets, the nanocarrier itself can also cause toxicity, and the toxicological properties of nanomaterials have gradually been paid attention to.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondly", ",", "although", "the", "combination", "of", "natural", "active", "ingredients", "and", "chemotherapy", "drugs", "can", "reduce", "the", "side", "effects", "of", "chemotherapy", "drugs", "by", "reducing", "the", "intake", "of", "chemotherapy", "drugs", "and", "directly", "acting", "on", "certain", "targets", ",", "the", "nanocarrier", "itself", "can", "also", "cause", "toxicity", ",", "and", "the", "toxicological", "properties", "of", "nanomaterials", "have", "gradually", "been", "paid", "attention", "to", "." ] } ]
PMC10165258
Timeline of the etoposide-cisplatin sequential assay. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Timeline", "of", "the", "etoposide-cisplatin", "sequential", "assay", ".", "(" ] } ]
PMC7171147
b Relative cell viability of ES2 cells expressing scrambled or shCPT1A vectors cultured in either COL11A1-positive or COL11A1-negative extract and treated with cisplatin (16 µM) for 72 h. N = 3; y-axis, cell viability (fold change); Error bar, SD; *p < 0.05; **p < 0.01.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Relative", "cell", "viability", "of", "ES2", "cells", "expressing", "scrambled", "or", "shCPT1A", "vectors", "cultured", "in", "either", "COL11A1-positive", "or", "COL11A1-negative", "extract", "and", "treated", "with", "cisplatin", "(", "16", "µM", ")", "for", "72", "h.", "N", "=", "3", ";", "y-axis", ",", "cell", "viability", "(", "fold", "change", ")", ";", "Error", "bar", ",", "SD", ";", "*", "p", "<", "0.05", ";", "*", "*", "p", "<", "0.01", "." ] } ]
PMC9429973
Patients in the PK deficiency cohort were matched 1:5 by age at index date, sex, and index year (±1 year) to patients from the general US VHA population with no diagnosis codes related to PK deficiency (non-PK deficiency cohort).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "in", "the", "PK", "deficiency", "cohort", "were", "matched", "1:5", "by", "age", "at", "index", "date", ",", "sex", ",", "and", "index", "year", "(", "±1", "year", ")", "to", "patients", "from", "the", "general", "US", "VHA", "population", "with", "no", "diagnosis", "codes", "related", "to", "PK", "deficiency", "(", "non-PK", "deficiency", "cohort", ")", "." ] } ]
PMC11781181
The declustering potential and collision energy (CE) were set at 100 V and 10 eV for ESI+ or at -100 V and -10 eV for ESI-, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "declustering", "potential", "and", "collision", "energy", "(", "CE", ")", "were", "set", "at", "100", "V", "and", "10", "eV", "for", "ESI+", "or", "at", "-100", "V", "and", "-10", "eV", "for", "ESI-", ",", "respectively", "." ] } ]
PMC11730305
The elevated percentage of the cells at the subG1 phase indicates the antimitotic property of Co3O4@Glu-Ellagic acid NPs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "elevated", "percentage", "of", "the", "cells", "at", "the", "subG1", "phase", "indicates", "the", "antimitotic", "property", "of", "Co3O4@Glu-Ellagic", "acid", "NPs", "." ] } ]
PMC10926885
While NDE1 expression was inversely connected with tumour grade in ESCA and OV, it was favourably correlated with tumour stage in ACC, KICH, LIHC and PAAD (Figure 1D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "NDE1", "expression", "was", "inversely", "connected", "with", "tumour", "grade", "in", "ESCA", "and", "OV", ",", "it", "was", "favourably", "correlated", "with", "tumour", "stage", "in", "ACC", ",", "KICH", ",", "LIHC", "and", "PAAD", "(", "Figure", "1D", ")", "." ] } ]
PMC11474209
Toxin first inactivates the enzyme by binding to it, and then, throughout an extended reaction time, the covalent bond forms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Toxin", "first", "inactivates", "the", "enzyme", "by", "binding", "to", "it", ",", "and", "then", ",", "throughout", "an", "extended", "reaction", "time", ",", "the", "covalent", "bond", "forms", "." ] } ]
PMC10366908
The model is also thought to be important for the evaluation of novel antibody–drug conjugates and prediction of the side-effects.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "model", "is", "also", "thought", "to", "be", "important", "for", "the", "evaluation", "of", "novel", "antibody", "–", "drug", "conjugates", "and", "prediction", "of", "the", "side-effects", "." ] } ]
PMC11607638
A stable baseline was observed in isolated rat pancreatic acini in the absence of any simulation (Figure 6F), but a physiological CCK concentration of only 10 pM triggered robust calcium oscillations (Figure 6G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "stable", "baseline", "was", "observed", "in", "isolated", "rat", "pancreatic", "acini", "in", "the", "absence", "of", "any", "simulation", "(", "Figure", "6F", ")", ",", "but", "a", "physiological", "CCK", "concentration", "of", "only", "10", "pM", "triggered", "robust", "calcium", "oscillations", "(", "Figure", "6", "G", ")", "." ] } ]
PMC11703896
Previous studies have reported that rapamycin has significantly lesser affinity to mTORC2 as compared to mTORC1 (Afzal et al. 2022).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "reported", "that", "rapamycin", "has", "significantly", "lesser", "affinity", "to", "mTORC2", "as", "compared", "to", "mTORC1", "(", "Afzal", "et", "al.", "2022", ")", "." ] } ]
PMC11499381
This experimental protocol used a previously characterized Cy5-labelled human αCGRP (Cy5 label on residue 3), which has similar pharmacology to the unmodified peptide .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "experimental", "protocol", "used", "a", "previously", "characterized", "Cy5-labelled", "human", "αCGRP", "(", "Cy5", "label", "on", "residue", "3", ")", ",", "which", "has", "similar", "pharmacology", "to", "the", "unmodified", "peptide", "." ] } ]
PMC10988555
The lipophilicity of the CoCp complexes was estimated by the shake-flask method.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lipophilicity", "of", "the", "CoCp", "complexes", "was", "estimated", "by", "the", "shake-flask", "method", "." ] } ]
PMC11098378
The fusion protein was affinity-purified using TALON metal affinity resin (Takara Biosciences) and eluted in buffer containing 50 mM Tris-HCl, 150 mM NaCl, 1 mM TCEP, 0.1 mM PMSF, and 250 mM Imidazole.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fusion", "protein", "was", "affinity-purified", "using", "TALON", "metal", "affinity", "resin", "(", "Takara", "Biosciences", ")", "and", "eluted", "in", "buffer", "containing", "50", "mM", "Tris-HCl", ",", "150", "mM", "NaCl", ",", "1", "mM", "TCEP", ",", "0.1", "mM", "PMSF", ",", "and", "250", "mM", "Imidazole", "." ] } ]
PMC11593084
Human PDPN PLAG4 domain knock-in mice were generated .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "PDPN", "PLAG4", "domain", "knock-in", "mice", "were", "generated", "." ] } ]
PMC9429973
Further studies in our center with a larger number of patients and a longer follow-up period will be conducted to evaluate the safety and efficacy of inotuzumab ozogamicin therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "in", "our", "center", "with", "a", "larger", "number", "of", "patients", "and", "a", "longer", "follow-up", "period", "will", "be", "conducted", "to", "evaluate", "the", "safety", "and", "efficacy", "of", "inotuzumab", "ozogamicin", "therapy", "." ] } ]
PMC11185260
During the treatment period, significant inhibition of tumor growth was evident with the combination treatment of radiation and scL-SMARCB1 compared to untreated tumors (Figure 7B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "treatment", "period", ",", "significant", "inhibition", "of", "tumor", "growth", "was", "evident", "with", "the", "combination", "treatment", "of", "radiation", "and", "scL-SMARCB1", "compared", "to", "untreated", "tumors", "(", "Figure", "7B", ")", "." ] } ]
PMC9429973
Notably, the VAF of SF3B1 in AML with NPM1 or RUNX1 was higher than the VAFs of NPM1 or RUNX1 in 9/11 (82%) cases, suggesting that SF3B1 preceded these mutations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "VAF", "of", "SF3B1", "in", "AML", "with", "NPM1", "or", "RUNX1", "was", "higher", "than", "the", "VAFs", "of", "NPM1", "or", "RUNX1", "in", "9/11", "(", "82", "%", ")", "cases", ",", "suggesting", "that", "SF3B1", "preceded", "these", "mutations", "." ] } ]
PMC2196094
We have detected substantial amounts of RMCP-5 mRNA in uninfected intestinal tissue, whereas mouse MMCs lack the expression of MMCP-5 (14).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "detected", "substantial", "amounts", "of", "RMCP-5", "mRNA", "in", "uninfected", "intestinal", "tissue", ",", "whereas", "mouse", "MMCs", "lack", "the", "expression", "of", "MMCP-5", "(", "14", ")", "." ] } ]
PMC11611077
The expression vectors were transfected into CHO cells using Lipofectamine 2000 (Thermo Fisher Scientific, Waltham, CA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "vectors", "were", "transfected", "into", "CHO", "cells", "using", "Lipofectamine", "2000", "(", "Thermo", "Fisher", "Scientific", ",", "Waltham", ",", "CA", ")", "." ] } ]
PMC10391797
The data suggest that T cell inhibition genes like PD-1 are negatively associated with CD8 memory T cells in patients with AML, which may lead to T cell dysfunction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "suggest", "that", "T", "cell", "inhibition", "genes", "like", "PD-1", "are", "negatively", "associated", "with", "CD8", "memory", "T", "cells", "in", "patients", "with", "AML", ",", "which", "may", "lead", "to", "T", "cell", "dysfunction", "." ] } ]
PMC10547921
Hence, a novel concept, antibody‒drug conjugates (ADCs) has been conceived and developed (Fig. 1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "a", "novel", "concept", ",", "antibody‒drug", "conjugates", "(", "ADCs", ")", "has", "been", "conceived", "and", "developed", "(", "Fig.", "1", ")", "." ] } ]
PMC11752740
Additionally, CFZ has been found to upregulate Caspase3, enhancing apoptosis in various cancer cell lines, including those associated with breast cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "CFZ", "has", "been", "found", "to", "upregulate", "Caspase3", ",", "enhancing", "apoptosis", "in", "various", "cancer", "cell", "lines", ",", "including", "those", "associated", "with", "breast", "cancer", "." ] } ]
PMC9429973
Clinical data and the analysis of the rest of the biomarkers is going on.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "data", "and", "the", "analysis", "of", "the", "rest", "of", "the", "biomarkers", "is", "going", "on", "." ] } ]
PMC9509578
Numerous engineered nanomaterials have emerged recently with the ability to deliver multiple agents such as chemotherapeutic drugs, adjuvants, and nucleic acids (DNA, siRNA, mRNA) to overcome MDR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "engineered", "nanomaterials", "have", "emerged", "recently", "with", "the", "ability", "to", "deliver", "multiple", "agents", "such", "as", "chemotherapeutic", "drugs", ",", "adjuvants", ",", "and", "nucleic", "acids", "(", "DNA", ",", "siRNA", ",", "mRNA", ")", "to", "overcome", "MDR", "." ] } ]
PMC9000591
Therefore, substances with high cytotoxic selectivity against the mentioned tumor cells and potent antioxidant activity could be prospective candidates to develop therapies for multiple myeloma and mantle cell lymphoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "substances", "with", "high", "cytotoxic", "selectivity", "against", "the", "mentioned", "tumor", "cells", "and", "potent", "antioxidant", "activity", "could", "be", "prospective", "candidates", "to", "develop", "therapies", "for", "multiple", "myeloma", "and", "mantle", "cell", "lymphoma", "." ] } ]
PMC9429973
The median number of prior TKIs were 4 [2-5], with 44% of prior lines stopped for resistance, and 56% for intolerance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "number", "of", "prior", "TKIs", "were", "4", "[", "2", "-", "5", "]", ",", "with", "44", "%", "of", "prior", "lines", "stopped", "for", "resistance", ",", "and", "56", "%", "for", "intolerance", "." ] } ]
PMC11129910
We observed RAB25 loss in transformed immortalized human mammary epithelial cell lines like RAO-3 and RAO-4 that were associated with H-RAS oncogene mutations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "RAB25", "loss", "in", "transformed", "immortalized", "human", "mammary", "epithelial", "cell", "lines", "like", "RAO-3", "and", "RAO-4", "that", "were", "associated", "with", "H-RAS", "oncogene", "mutations", "." ] } ]
PMC9429973
In addition, GR blockade (RU486) significantly reversed the effects of G-CSF, demonstrating that GR up-regulates SOCS1 and inhibits the production of IFN-γ by NK cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "GR", "blockade", "(", "RU486", ")", "significantly", "reversed", "the", "effects", "of", "G-CSF", ",", "demonstrating", "that", "GR", "up-regulates", "SOCS1", "and", "inhibits", "the", "production", "of", "IFN-γ", "by", "NK", "cells", "." ] } ]
PMC11490153
A crucial element of the tumor microenvironment is hypoxia, which results from rapid tumor growth and insufficient blood supply .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "crucial", "element", "of", "the", "tumor", "microenvironment", "is", "hypoxia", ",", "which", "results", "from", "rapid", "tumor", "growth", "and", "insufficient", "blood", "supply", "." ] } ]
PMC9429973
Most patients were in stage 3 (9.8%) and stage 4 (72.1%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "patients", "were", "in", "stage", "3", "(", "9.8", "%", ")", "and", "stage", "4", "(", "72.1", "%", ")", "." ] } ]
PMC11770746
UV detection was set at 220 nm in both the HPLC systems.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UV", "detection", "was", "set", "at", "220", "nm", "in", "both", "the", "HPLC", "systems", "." ] } ]
PMC10443665
The effect of all three compounds on MDR1 expression was evaluated using RT-PCR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "all", "three", "compounds", "on", "MDR1", "expression", "was", "evaluated", "using", "RT-PCR", "." ] } ]
PMC10850553
The images of immunofluorescent staining of control arterial walls (Superficial temporal artery) or IA lesions for C5AR1 (green), a marker for endothelial cells, CD31 (red), a marker for smooth muscle cells, α-smooth muscle actin (SMA, red), a marker for neutrophils, Myeloperoxidase (red), and merged images with nuclear staining by DAPI (blue) are shown.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "images", "of", "immunofluorescent", "staining", "of", "control", "arterial", "walls", "(", "Superficial", "temporal", "artery", ")", "or", "IA", "lesions", "for", "C5AR1", "(", "green", ")", ",", "a", "marker", "for", "endothelial", "cells", ",", "CD31", "(", "red", ")", ",", "a", "marker", "for", "smooth", "muscle", "cells", ",", "α-smooth", "muscle", "actin", "(", "SMA", ",", "red", ")", ",", "a", "marker", "for", "neutrophils", ",", "Myeloperoxidase", "(", "red", ")", ",", "and", "merged", "images", "with", "nuclear", "staining", "by", "DAPI", "(", "blue", ")", "are", "shown", "." ] } ]
PMC9776316
Ovarian cancer patients were stratified into two groups: the sensitive group (n = 22, patients who responded to platinum-based chemotherapy durably for at least 6 months) and the resistant group (n = 9, patients who relapsed within the 6 months and did not respond to platinum therapy).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ovarian", "cancer", "patients", "were", "stratified", "into", "two", "groups", ":", "the", "sensitive", "group", "(", "n", "=", "22", ",", "patients", "who", "responded", "to", "platinum-based", "chemotherapy", "durably", "for", "at", "least", "6", "months", ")", "and", "the", "resistant", "group", "(", "n", "=", "9", ",", "patients", "who", "relapsed", "within", "the", "6", "months", "and", "did", "not", "respond", "to", "platinum", "therapy", ")", "." ] } ]
PMC8759873
After that, pEGFP-VHL was transfected using ultrasonic microbubble and liposome gene transfection techniques, respectively, and the transfection efficiency was measured by immunofluorescence.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", ",", "pEGFP-VHL", "was", "transfected", "using", "ultrasonic", "microbubble", "and", "liposome", "gene", "transfection", "techniques", ",", "respectively", ",", "and", "the", "transfection", "efficiency", "was", "measured", "by", "immunofluorescence", "." ] } ]
PMC11766174
For this, fresh human PBMCs were activated with phytohemagglutinin (PHA) at a concentration of 5 µg/mL in complete RPMI-1640 (cRPMI) medium with 10% fetal bovine serum (FBS) and 20 U/mL Interleukin-2 (IL-2) for 3 days.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", ",", "fresh", "human", "PBMCs", "were", "activated", "with", "phytohemagglutinin", "(", "PHA", ")", "at", "a", "concentration", "of", "5", "µg/mL", "in", "complete", "RPMI-1640", "(", "cRPMI", ")", "medium", "with", "10", "%", "fetal", "bovine", "serum", "(", "FBS", ")", "and", "20", "U/mL", "Interleukin-2", "(", "IL-2", ")", "for", "3", "days", "." ] } ]
PMC11599565
SKOV3 cells after exposure to cisplatin undergo a neuronal de-differentiation and initiate a prominent network with adjacent cells or with other neuronal like cells (Fig. 2, Panel B) similar to the cell–cell interactions observed in cultures of differentiated neurons isolated from normal colon.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SKOV3", "cells", "after", "exposure", "to", "cisplatin", "undergo", "a", "neuronal", "de-differentiation", "and", "initiate", "a", "prominent", "network", "with", "adjacent", "cells", "or", "with", "other", "neuronal", "like", "cells", "(", "Fig.", "2", ",", "Panel", "B", ")", "similar", "to", "the", "cell", "–", "cell", "interactions", "observed", "in", "cultures", "of", "differentiated", "neurons", "isolated", "from", "normal", "colon", "." ] } ]
PMC11001582
Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral sclerosis (C9ALS)/frontotemporal dementia (FTD) pathology, but their physiological impact has yet to be fully determined.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dipeptide", "repeat", "proteins", "are", "a", "major", "pathogenic", "feature", "of", "C9orf72", "amyotrophic", "lateral", "sclerosis", "(C9ALS)/frontotemporal", "dementia", "(", "FTD", ")", "pathology", ",", "but", "their", "physiological", "impact", "has", "yet", "to", "be", "fully", "determined", "." ] } ]
PMC11640555
However, CX-4945 reduced U-87, U-138, and A-172 cell viability in a concentration-dependent manner (Figure 1B), especially the concentrations of 5, 10, and 15 μM, which reduced the cell viability of U-87cells to 80%, 77%, and 69%, respectively.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "CX-4945", "reduced", "U-87", ",", "U-138", ",", "and", "A-172", "cell", "viability", "in", "a", "concentration-dependent", "manner", "(", "Figure", "1B", ")", ",", "especially", "the", "concentrations", "of", "5", ",", "10", ",", "and", "15", "μM", ",", "which", "reduced", "the", "cell", "viability", "of", "U-87cells", "to", "80", "%", ",", "77", "%", ",", "and", "69", "%", ",", "respectively", "." ] } ]
PMC10919056
An EdU Kit (Beyotime, Shanghai, China) was used to detect cell proliferation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "EdU", "Kit", "(", "Beyotime", ",", "Shanghai", ",", "China", ")", "was", "used", "to", "detect", "cell", "proliferation", "." ] } ]
PMC9429973
No phenotype changes were observed in the relapsed cells in palbociclib and ponatinib groups compared to vehicle (SSClowCD45dim blasts, SSCdimCD45high monocytes, CD34+ and CD34+CD38- cells).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "phenotype", "changes", "were", "observed", "in", "the", "relapsed", "cells", "in", "palbociclib", "and", "ponatinib", "groups", "compared", "to", "vehicle", "(", "SSClowCD45dim", "blasts", ",", "SSCdimCD45high", "monocytes", ",", "CD34", "+", "and", "CD34+CD38-", "cells", ")", "." ] } ]
PMC11286266
The mixture was incubated overnight at 4°C with rotation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "incubated", "overnight", "at", "4", "°", "C", "with", "rotation", "." ] } ]
PMC10565698
Since most LC is insidious and progresses promptly, the onset of symptoms is generally at an advanced stage .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "most", "LC", "is", "insidious", "and", "progresses", "promptly", ",", "the", "onset", "of", "symptoms", "is", "generally", "at", "an", "advanced", "stage", "." ] } ]
PMC3675084
BPR0L075 induced cell death in both parental and paclitaxel-resistant ovarian cancer cells proceed through caspase-3 independent mechanisms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BPR0L075", "induced", "cell", "death", "in", "both", "parental", "and", "paclitaxel-resistant", "ovarian", "cancer", "cells", "proceed", "through", "caspase-3", "independent", "mechanisms", "." ] } ]
PMC9429973
Image: Summary/Conclusion: Our study showed that hMDS patients have similar outcomes with non-hMDS pts with unique molecular profiles.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "Our", "study", "showed", "that", "hMDS", "patients", "have", "similar", "outcomes", "with", "non-hMDS", "pts", "with", "unique", "molecular", "profiles", "." ] } ]
PMC10938336
Compound 1 showed no activity, and compound 3 displayed toxicity in BJ cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "1", "showed", "no", "activity", ",", "and", "compound", "3", "displayed", "toxicity", "in", "BJ", "cells", "." ] } ]
PMC11469524
This is a good indication that the model development did not lead to overfitting.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "good", "indication", "that", "the", "model", "development", "did", "not", "lead", "to", "overfitting", "." ] } ]
PMC11679326
Mannose-specific lectin BPL2 isolated from the seaweed Bryopsis plumosa was shown to be effective against lung cancer A549, H460, and H1299 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Mannose-specific", "lectin", "BPL2", "isolated", "from", "the", "seaweed", "Bryopsis", "plumosa", "was", "shown", "to", "be", "effective", "against", "lung", "cancer", "A549", ",", "H460", ",", "and", "H1299", "cells", "." ] } ]
PMC10452486
The treated cells were then incubated at 37 °C in the presence or absence of BFA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "treated", "cells", "were", "then", "incubated", "at", "37", "°", "C", "in", "the", "presence", "or", "absence", "of", "BFA", "." ] } ]
PMC11680562
The calcium ions (Ca) of CaCl2 interact with the carboxyl groups in the polymers, triggering the crosslinking of neighboring pectin chains via a process called "egg-box" production .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calcium", "ions", "(", "Ca", ")", "of", "CaCl2", "interact", "with", "the", "carboxyl", "groups", "in", "the", "polymers", ",", "triggering", "the", "crosslinking", "of", "neighboring", "pectin", "chains", "via", "a", "process", "called", "\"", "egg-box", "\"", "production", "." ] } ]
PMC11023271
Future studies will provide pathway analysis to define these pathways.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "studies", "will", "provide", "pathway", "analysis", "to", "define", "these", "pathways", "." ] } ]
PMC10440586
3Increased CD99 expression is associated with the immune adaptation dominated by TAMs in gliomas. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Increased", "CD99", "expression", "is", "associated", "with", "the", "immune", "adaptation", "dominated", "by", "TAMs", "in", "gliomas", ".", "(" ] } ]
PMC8316344
In Bel-7404 cells, knocking TRIB2 out resulted in a significant suppression on the ubiquitination of TFRC, and such effects were blocked once upon βTrCP was also knocked out (Fig. 5H).
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Bel-7404", "cells", ",", "knocking", "TRIB2", "out", "resulted", "in", "a", "significant", "suppression", "on", "the", "ubiquitination", "of", "TFRC", ",", "and", "such", "effects", "were", "blocked", "once", "upon", "βTrCP", "was", "also", "knocked", "out", "(", "Fig.", "5H", ")", "." ] } ]
PMC9429973
Our approach does not affect the cellular viability or the hematologic recovery of the patients following transplantation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "approach", "does", "not", "affect", "the", "cellular", "viability", "or", "the", "hematologic", "recovery", "of", "the", "patients", "following", "transplantation", "." ] } ]
PMC11738017
Acquired resistance to anti-BCMA TCE is caused by selective clonal expansion of BCMA antigen escape clones that have biallelic deletions of TNFRSF17 or mutations in the ECD of BCMA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acquired", "resistance", "to", "anti-BCMA", "TCE", "is", "caused", "by", "selective", "clonal", "expansion", "of", "BCMA", "antigen", "escape", "clones", "that", "have", "biallelic", "deletions", "of", "TNFRSF17", "or", "mutations", "in", "the", "ECD", "of", "BCMA", "." ] } ]
PMC11322866
In our previous study, we demonstrated that GSK126, an EZH2 inhibitor, exhibited therapeutic efficacy and safety in MM xenograft mice , but its specific mechanism remains unclear.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "previous", "study", ",", "we", "demonstrated", "that", "GSK126", ",", "an", "EZH2", "inhibitor", ",", "exhibited", "therapeutic", "efficacy", "and", "safety", "in", "MM", "xenograft", "mice", ",", "but", "its", "specific", "mechanism", "remains", "unclear", "." ] } ]
PMC10047551
However, AZA treatment resulted in the demethylation of the PD-L1 promoter, increased PD-L1 mRNA expression, and induced sensitization to anti-PD-1 therapy in a mouse model of immunotherapy resistance .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "AZA", "treatment", "resulted", "in", "the", "demethylation", "of", "the", "PD-L1", "promoter", ",", "increased", "PD-L1", "mRNA", "expression", ",", "and", "induced", "sensitization", "to", "anti-PD-1", "therapy", "in", "a", "mouse", "model", "of", "immunotherapy", "resistance", "." ] } ]
PMC11794568
Fig. 3CRIP1 overexpression inhibits proliferation and invasion of cutaneous melanoma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3CRIP1", "overexpression", "inhibits", "proliferation", "and", "invasion", "of", "cutaneous", "melanoma", "cells", "." ] } ]
PMC9429973
These results are consistent with earlier Phase I data in 100 patients treated with target glofitamab doses ≥10mg (CR rate: 34%; estimated 20-month CR rate in complete responders: 72%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "are", "consistent", "with", "earlier", "Phase", "I", "data", "in", "100", "patients", "treated", "with", "target", "glofitamab", "doses", "≥10", "mg", "(", "CR", "rate", ":", "34", "%", ";", "estimated", "20-month", "CR", "rate", "in", "complete", "responders", ":", "72", "%", ")", "." ] } ]
PMC11750712
Target cells were labeled with CellTrace CFSE (C34554, Thermo Fisher Scientific) following the manufacturer’s instructions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Target", "cells", "were", "labeled", "with", "CellTrace", "CFSE", "(", "C34554", ",", "Thermo", "Fisher", "Scientific", ")", "following", "the", "manufacturer", "’s", "instructions", "." ] } ]
PMC9351137
Synchronization of the HeLa cells was performed according to Messina et al. .
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synchronization", "of", "the", "HeLa", "cells", "was", "performed", "according", "to", "Messina", "et", "al.", "." ] } ]
PMC10812665
Best known is the reduction of oxygen to superoxide and hydrogen peroxide.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Best", "known", "is", "the", "reduction", "of", "oxygen", "to", "superoxide", "and", "hydrogen", "peroxide", "." ] } ]
PMC8010066
A weaker effect of S. aureus on P.aeruginosa PA-2 and PA-3 strains was reported in comparison with P.aeruginosa PA-4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "weaker", "effect", "of", "S.", "aureus", "on", "P.aeruginosa", "PA-2", "and", "PA-3", "strains", "was", "reported", "in", "comparison", "with", "P.aeruginosa", "PA-4", "." ] } ]
PMC4360730
As internal checks that are part of curation interfaces, we have created a facet using a subset of terms from OBI that organizes assays by major assay categories (Figure 5).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "internal", "checks", "that", "are", "part", "of", "curation", "interfaces", ",", "we", "have", "created", "a", "facet", "using", "a", "subset", "of", "terms", "from", "OBI", "that", "organizes", "assays", "by", "major", "assay", "categories", "(", "Figure", "5", ")", "." ] } ]
PMC9545714
IL‐17 expression was not upregulated after 6 h of GTE treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IL‐17", "expression", "was", "not", "upregulated", "after", "6", "h", "of", "GTE", "treatment", "." ] } ]
PMC9429973
Results: From July 2020 to December 2021, a total of eight elderly unfit DLBCL patients were enrolled.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "From", "July", "2020", "to", "December", "2021", ",", "a", "total", "of", "eight", "elderly", "unfit", "DLBCL", "patients", "were", "enrolled", "." ] } ]
PMC9429973
Results: PCM substrate by histologic examination in bone marrow trepnines and bone plasmacytomas biopsy specimens were presented by mature plasma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "PCM", "substrate", "by", "histologic", "examination", "in", "bone", "marrow", "trepnines", "and", "bone", "plasmacytomas", "biopsy", "specimens", "were", "presented", "by", "mature", "plasma", "cells", "." ] } ]