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OTAR3088
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BioData-CellLine_annotated

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PMC11243198
Our findings show promise in developing more effective and potent GLI inhibitors.
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PMC6684588
These data demonstrate that local administration of ACE-083 in wild-type mice causes focal muscle growth due to fiber hypertrophy.
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PMC11411004
DMSO, dimethylsulfoxide; HDACs, histone deacetylases. ****
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PMC9429973
Progression to AML occurred in 186 (43%) of the patients.
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PMC11547972
CAM encompasses non-conventional therapies such as phytomedicine and probiotics, and mind-body practices such as acupuncture and hypnosis.
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PMC7081114
Fluorescence-activated cell sorting analysis was used to determine the effect of KIF21B knockdown in inducing apoptosis.
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PMC10605143
Spheroids were observed under the Axiovert 40 CFL microscope (Carl Zeiss), and pictures were taken.
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PMC9786247
The plasmid status of C. burnetii strains was determined by multiplex PCR .
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PMC11628904
Finally, we applied our finding that isotonic medium treatment limits the spread of burn damage in zebrafish to cultured human skin.
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PMC11740573
The outer membrane is an additional barrier for numerous antibiotic molecules.
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PMC11464982
Two separate experiments were performed with duplicate cultures of TK6 human lymphoblastoid cell line.
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PMC6643347
Characterization of the chemical composition of SBF-HS Studies of the elemental composition of SBF-HS were performed in two repetitions.
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PMC11055510
However, the molecular mechanism of circMAN1A2 in OC is still unclear.
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PMC11739504
Nuclei were stained with DAPI (blue). (
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PMC9429973
No pt had disease progression with a median follow-up of close to 5 years.
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PMC11684297
A step forward, we conducted the Live dead assay for A375 cells after exposure to 50 µg/ml and 100 µg/ml of ZnO-NFs (Fig. 4b).
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PMC9712534
Chemiluminescence was detected using a ChemiDoc XRS Plus imaging system (Bio-Rad, USA) and quantified using ImageLab software (Version 2.0, Bio-Rad).
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PMC9429973
The treatment effect of CML patients with NOTCH3, RELN and ASXL1 mutations and more than two gene mutations is poor.
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PMC11422497
Reports indicate that circRNAs are implicated in diverse biological processes, including signal transduction, transcription, cell cycle regulation, RNA-binding protein interactions, stress responses, protein metabolism, cellular immunity, and cell structure.
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PMC11075223
Cardiovascular disease, including thrombosis induced by platelet aggregation, is one of the main causes of death worldwide.
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PMC9429973
Methods: Eligibility: Primary or post-ET/PV MF; DIPSS high risk, Int-2, or Int-1; MF Symptom Assessment Form Total Symptom Score (MFSAF TSS) ≥10; hemoglobin (Hgb) <10 g/dL; prior JAKi for ≥90 days, or ≥28 days if RBC transfusions ≥4 units in 8 wks or Gr 3/4 thrombocytopenia, anemia, or hematoma; palpable spleen ≥5 cm; PLT ≥25 x 10/L. JAKi taper and washout was ≥21 days.
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PMC9429973
Interim molecular response (iMR) was defined as lack tumor reporters in cfDNA collected at the interim timepoint (sensitivity 10).
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PMC11714165
The therapeutic efficacy of DN‐F was then tested in an orthotopic xenograft model of 143B osteosarcoma.
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PMC11518994
Strikingly, the disease samples from both siblings carried an identical additional somatic pathogenic PAX5 p.Pro80Arg variant (c.239C>G, p.Pro80Arg; variant fraction: 29% in Case A and 38% in Case B), which has been functionally characterized as a pathogenic variant promoting leukemogenesis [10–13].
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PMC9424261
Co-IP experiment was used to verify whether the ubiquitination level of GSS has changed in WT or HERPUD1-sg1 liver cancer cells.
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PMC11040965
In vitro transfection of U266 and RPMI 8226 cells with a miR29b mimic downregulates the PI3K/AKT pathway and DNMT3B expression, restores proteasome subunit levels, and promotes myeloma cell killing by bone marrow CD8 T cells from MM patients.
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PMC11471157
H, I) Transmission electron microscope image of DFP.
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PMC10743717
It was also found to be a substrate of Parkin, the cytosolic E3 ubiquitin-protein ligase , and thus involved in mitochondrial quality control .
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PMC9429973
However, there is no clear molecular-genetic characteristic of PMBCL.
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PMC9545474
The five complexes are stable under these conditions (Figures S24–S28).
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PMC11594588
Several pathways are involved in the pathophysiology of HF, which are key therapeutic targets.
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PMC10291556
Notably, the presence of DCF in Pt(IV) complexes 3 and 4 containing DCF axial ligand(s) was reflected in the higher potency of the two complexes to reduce the amount of tubulin as compared to complexes 1 and 2 containing no DCF ligand.
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PMC6312945
Therefore, the expression levels of miR-101 and miR-345 are closely related to HBV replication.
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PMC9429973
We also show that the specific activity of UCART20x22 persists over time against tumor cells expressing either one or both antigens.
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PMC11683130
The inhibitory SerpinA9 is involved in maturation and maintenance of naïve B cells (50).
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PMC11409031
A study carried out by Jing Zhang and co-authors revealed that HLA-F-AS1 boosts PFN1 expression in extracellular vesicles of colorectal cancer (CRC) through miR-375 inhibition.
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PMC11634027
Bottom two panels show blots on proteins immunoprecipitated with anti-V5 beads and detected with V5 or FLAG antibody. (
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PMC9429973
Across cohorts, the median age was 68 years (range: 36–80).
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PMC11089031
The study was approved by the Institutional Review Board of MengChao Hepatobiliary Hospital of Fujian Medical University for the use of patient samples.
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PMC9429973
First line salvage therapy was BB chemotherapy in 3 patients with obtaining a CR in 1 patient and death during chemotherapy in 2 patients.
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PMC8701144
Following blocking of the PVDF membranes (5% nonfat dry milk (AppliChem, Darmstadt, DE) in TBST, 1 h room temperature), immunodetection of proteins was performed by incubation with primary antibodies overnight at 4 °C and incubation with secondary antibodies for 1 h at room temperature.
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PMC9429973
At data cutoff, 4 cases had recovered, and 4 had not recovered.
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PMC10936243
As some behavioural indicators of stress and pain overlap, minimal stress experienced by cat patients may help veterinary professionals to better understand and recognise pain behaviours in cats.
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PMC11757230
2Differential effects of canine adipose-derived mesenchymal stromal cells (cADSCs) on leukemia/lymphoma (LL) cell survival.
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PMC7602170
In the few cases where either CD117 or DOG1 are negative, a molecular analysis should be considered.
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PMC9792775
Next, we placed a therapeutic low-frequency transducer of approximately 15 mm diameter on the skin of the mice and covered the entire tumor load of each mouse with contact medicinal foam.
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PMC11731614
Importantly, we found similar quantities based on the number of spectral counts of the canonical EV-associated proteins Alix and Syntenin-1 in both samples with decreased detected levels of Tsg101 in HFD KDEVs (Fig. 3C).
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PMC11798926
The total stain integrated density for the SynDIG2∆135–55 deletion mutant was very low, perhaps because the HA epitope recognized by the α-HA antibody used for labeling total protein was blocked by the α-HA antibody used for surface staining.
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PMC11752740
Furthermore, this highlights the interplay between the NF-κB and caspase pathways; the inhibition of NF-κB by CFZ and pistachio hull extract likely sensitizes cancer cells to apoptosis.
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PMC11629143
Each biological repeat sample was then loaded in duplicate on an Admiral cycler with 45 amplification cycles.
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PMC2193049
Although it has been shown that amino acids at position 156 could positively influence the generation of the antigenic peptide NP147–155 (39), we did not observe any effect of the amino acid at the COOH terminus of the cleavage site of peptide MAGE-3271–279.
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PMC11754784
The constructed kinetic model can help us to predict the feasibility of more complex DNA computations in cellular microenvironment.
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PMC11683240
Taken together, these data provide the first evidence that α1AT administration may be a valid approach for the treatment of PT-mediated pertussis manifestations in infants and support the need for further studies to comprehensively evaluate and optimize α1AT treatment strategies for this severe disease.
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PMC4659567
To get an evidence for the formation of the mentioned species, ESI mass spectrometry experiments were performed on 2 dissolved in 10% DMF/H2O solution.
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PMC11244823
The plates were gently shaken on a plate shaker (300rpm) and luciferase activity was measured as described above.
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PMC11343332
In recent years, natural compounds such as pycnogenol have been explored as potential alternatives or complementary therapies for cancer .
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PMC11792888
The run conditions were as follows: phase A - 0.1% TFA in HPLC grade water; phase B - 0.1% TFA in acetonitrile.
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PMC11092418
In one study, Wang et al found CD44 expression may be associated with invasion and migration of glioma .
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PMC11457557
Characterization of the genetic factors involved in the development of DM and its consequences is expected to lead to a better understanding of molecular etiology and the development of new treatment methods.
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PMC10976516
Thereby, the Delta-24 deletion in E1A renders the adenovirus deficient in replication in normal cells that are out of the cell cycle in a post-mitotic status.
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PMC11188874
The two outer rings are identical and contain seven different α-subunits, whereas the two identical inner rings contain seven different β-subunits, three of which, β1, β2, and β5, exert catalytic activities (13).
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PMC10047551
The mRNA expression analysis of the effect of these deletions showed a significant but negligible upregulation of PD-L1 mRNA expression in the HCC827 cells and no significant alteration in PD-L1 mRNA expression in the A427 cells (Figure 3B and Figure S4A).
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PMC9429973
Aims: To evaluate the efficacy and safety of bendamustine, Pomalidomide, and dexamethasone (BPd) for relapsed / refractor multiple myeloma with EMD.
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PMC9429973
Results: As of 18 January 2021, a total of 68 pts were enrolled (Table).
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PMC11098378
These cutoffs were chosen to avoid false positives stemming from experimental noise within our screening system and allowed us to focus on effectors that robustly rescued arbovirus replication.
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PMC11773391
So we speculated that vMF can only decrease the level of the MGMT protein under TMZ‐induced ERK activation.
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PMC11615101
The stimulation of α-Taxilin results in increased cyclic adenosine monophosphate (cAMP), which is well established as a potent regulator of innate and adaptive immune cell function.21 The study shows α-Taxilin also contributes to B cell memory in humans and extended B-cell populations in animals correlating with increased serum antibodies and susceptibility to autoimmune disease.22 However, there is a lack of clear understanding of its mechanistic involvement in inflammation and autoimmune disease.
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PMC5916734
Isolation and purification of FIX FIX was isolated and purified as follows: the culture medium was loaded into a column packed with the Capto MMC sorbent and equilibrated with a 20 mM sodium citrate solution, pH 7.0, 100 mM NaCl, 0.02% Tween 80; and washed with a 20 mM sodium citrate solution, pH 7.0, 0.1 M NaCl.
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PMC9429973
Results: We identified 445 DLBCL-patients (2015-2016) out of them 89.4% (n=398) were treated with R-CHOP in 1-line therapy.
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PMC11738017
BCMA ECD mutations confer selective loss of epitopes and hence lead to the differential abrogation of anti-BCMA TCE efficacies while retaining BCMA surface expression.
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PMC10040136
Notably, the expression of TGF-β2 by MSC did not exhibit significant changes when cultured alone or in non-contact co-culture conditions.
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PMC11585565
The Thr495 residue stabilizes the side chain of Asp498 and facilitates the binding of Mg-ATP.
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PMC10094712
The Fura-2 was excited and recorded using an HCX PL APO 20.0 × 0.70 IMM UV lens with a refractive index of 1.52.
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PMC11640115
For the mGPS, 37 cases scored 0, 5 cases scored 1, and 12 cases scored 2, whereas for the imGPS, 14 cases scored 0, 21 cases scored 1, 9 cases scored 2, and 10 cases scored 3, indicating that the imGPS was able to allocate cases more evenly.
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PMC6650823
As a result, the authors identified three molecules as valuable starting material for developing compounds specifically tailored to target the bacteria-specific Q biosynthetic pathway.
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PMC11412721
A typical experiment for cells of each genotype and condition is shown, with % of cells in G1, S, and G2/M mentioned in each panel. (
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PMC11301242
As an indirect comparison, survival data of AML patients from The Cancer Genome Atlas (TCGA) database was downloaded.
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PMC6643347
Macrophages also vary in their ability to produce the virus.
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PMC11585587
In comparison the experimental group with the no-treatment control, *P < 0.05 was considered statistically significant.
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PMC9684669
Calculated CI values are presented below the plots.
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PMC9583612
Each column represents a round of measurement by either Bridger or SeekOps.
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PMC9370419
After 12 h, the cells were lysed using the Nano-Glo HiBiT Lytic Detection System (Promega, Madison, WI, USA) following the manufacturer’s protocol.
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PMC11344246
Although the pipeline identified novel druggable targets, there is significant room for improvement.
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PMC11406030
Histological classifications (high-grade serous carcinoma [HGSC], EC, MC, and CCC) were updated by a certified pathologist in accordance with current World Health Organization guidelines.
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PMC11047729
In the first case, it acts as a ligand and binds to a heterodimer of RXR and RAR.
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PMC11741577
We found that wound closure was significantly faster in HMC-1 CM than in serum-free IMDM (control) at the 24 and 48 h time points (Fig 1B).
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PMC9429973
35 patients (31%) had a statistically significant (P=0.01) increases in RBC, RBC indices, hemoglobin (Hb) levels after intravenous iron supplementation.
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PMC9429973
R, platelets ≥ 30 × 10 / L, with at least doubling baseline; CR, platelets ≥ 100 × 10 / L) Results: Eleven consecutive patients were enrolled, and the therapeutic effect was shown in Table 1.
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PMC11513011
Tumors with a major axis of 20 mm were set for euthanasia and no mice had tumors with a major axis exceeding 20 mm.
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PMC9822769
Indeed, 2 does not represent the lead candidate for Pt(IV) anticancer prodrugs, as dozens of lipophilic and multifunctional analogues exhibit much higher cytotoxic activity (in the nM range) .
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PMC11670407
These data suggest that GPX4 could be a potential target of OTULIN for resistance to cisplatin-induced apoptosis.
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PMC11777207
Furthermore, the cytoplasmic tail of CD80 has shown its own propensity for cell intrinsic signaling in APCs upon ligation with its binding partners (27, 54, 55).
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PMC11469524
Reporter ion MS2 for TMT11 was selected (internal and N-terminal) and TMT batch specific corrections factors were specified.
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PMC11656048
The flow cytometry assay showed that shikonin could induce cell cycle arrest at G1→S phase, increased the G1 phase percentage and decreased S, G2/M phase percentage of MG63 and 143B (Figures 1J, K).
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PMC9429973
Aims: We aim to test the hypothesis that SHP1 may play a role in defining the level of the activity of the BCR pathway and impact on the response to ibrutinib.
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PMC10976516
Oncolysis, which is brought on by virus replication, results in the production of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs, respectively), as well as antigens associated with tumors (TAAs) and viruses.
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PMC11791264
∗∗∗∗p < 0.0001 (Two-way ANOVA followed by Dunnett’s multiple comparison).
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PMC11564322
It has also been demonstrated that EDPs stimulate differentiation of human T helper type 1 (Th-1) lymphocytes .
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PMC9429973
Also, product placement will impact the outcome, as wrist-worn devices are more susceptible to noise than chest-worn devices.
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PMC11593713
TAC was expressed as µM of Trolox (standard) per mg of protein of the tested sample.
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