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OTAR3088
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BioData-CellLine_annotated

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PMC11461833
STXBP5L is associated with senescence in skin ageing, as indicated by the results of a genome-wide association study (GWAS) of 502 middle-aged French Caucasian women.
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PMC11756514
One superfamily of carbohydrate-binding proteins in mammals is the C-type lectins (CTLs).
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PMC11684297
The trypan blue dye exclusion assay was also done after 24 h of treatment with different doses of ZnO-NFs.
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PMC11763126
Our study demonstrated the inhibitory effects of CBDP1 on ccRCC progression both in vitro and in vivo.
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PMC4695073
The survival curve of stage IIIA patients was similar to the one of stage II, while that of stage IIIB was near to that of stage IVa/b (Supplemental Figure S4D).
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PMC10788478
Patients with NSCLC are usually diagnosed with metastatic diseases, and the survival rate of stage IV patients with NSCLC is extremely low.
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PMC7602170
When the ligand binds to its specific RTK, the signal transduction adaptor protein (such as insulin receptor substrate 1, IRS1) is phosphorylated, thereby leading to PI3K activation .
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PMC9429973
Results: The Fy antigen was detected in 75.2% of those who did not become ill and in 60.6% of those who had COVID-19 (p<0.05).
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PMC11049548
Cells were sub-cultured twice weekly, splitting them 1:5 (3–6 × 10 cells per cm).
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PMC6771295
Protein levels were analyzed using antibodies specific for the LC3 and Beclin-1 autophagy markers.
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PMC10734950
For example, 2- Butylthiophene, a well-known thiophene has been used in the process of synthesizing anti-cancer agents.
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PMC10747160
Overall, in this publication, we examined how the structural features of Griffithsin affected its ability to prevent SARS-CoV-2 pseudotyped lentiviral infection.
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PMC7553912
b,d) Quantitative analysis of the protein expressions of OPN, ANXA1, and ANXA2 on day 3 (b) and day 6 (d).
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PMC9596868
Table 1Combinatorial treatments reported for quercetin with chemotherapeutic drugs/compounds in cancer cell lines.
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PMC10728200
MG132 (5 μM) was added for stabilizing GPX4.
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PMC3995603
The absorbance was then evaluated at 535 nm using a calibration curve generated using the standards.
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PMC7812570
A single-cycle infection assay was carried out as described previously.
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PMC6487404
These results are consistent with a report by Niemi et al. showing that clarithromycin, a CYP3A4 inhibitor, significantly increased the AUC0–∞ and Cmax of REG and enhanced its blood glucose-lowering effect (29).
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PMC9429973
Results: We identified 7 functional subsets of BMPCs in AL, MGUS or healthy controls (Fig. 1a).
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PMC9429973
The high discriminatory capacity of the HT10 score for infections emphasizes the utility of procalcitonin in routine inflammatory panels.
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PMC11448304
Despite its effectiveness, resistance to radiation remains a major cause of therapy failure .
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PMC10578720
The human hepatoblastoma cell line HepG-2.2.15 (KeyGEN Biotech Co. Ltd., Jiangsu, China) was used to generate and collect HBV particles as described.
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PMC11746948
Then, 100 μL of the cell lysate was taken as the input sample, and the remaining lysate was diluted tenfold with NP40 lysis buffer.
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PMC11496491
The analysis results of GO directed acyclic graph in terms of molecular function are shown in Fig. 8.
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PMC7802142
As previous reports, mesenchymal stem cell (MSC)-derived EVs could promote wound healing by inducing proliferation and migration of fibroblast, as well as angiogenesis in vitro .
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PMC11394227
The RTCA instrument detected the proliferation curves of two monoclonal cell lines, shown in Figure 1D.
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PMC11013014
One of the most promising targets for the development of anticancer agents is the resistance against existing drugs, which remains a major challenge to overcome .
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PMC11306331
Negative values indicate condensate dissolution.
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PMC11718109
Scale bars, 10 μm; insets: 2.5 μm.
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PMC11468365
Figure 1 illustrates the structure of the MultiComb model.
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PMC9429973
Assessment of cytokine profiles in culture media was done with Luminex multiplex immunoassay.
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PMC9429973
Among previous treatments, predonisone (92.9%, n=13), tacrolimus (50%, n=7), sirolimus (50%, n=7) and photoapheresis (35.7%, n=5) were the most frequently used.
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PMC7229095
4Testing mixtures of commercial cloning media and CDM2 to achieve successful single cloning a 10% conditioned media, b No conditioned media added, 0.5 cells/well are inoculated in 96-well plates and wells showing colony growth are detected Testing mixtures of commercial cloning media and CDM2 to achieve successful single cloning a 10% conditioned media, b No conditioned media added, 0.5 cells/well are inoculated in 96-well plates and wells showing colony growth are detected The final clone evaluation was followed by culturing in well-plates directly without any suspension adaptation in shake flask, and microscale bioreactor since the host cells were already pre-adapted to each media as a suspension culture before the transfection.
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PMC10729469
B Y maze test performed on experimental mice after adoptive transfers to evaluate spontaneous alteration in mice freely exploring each arm of the Y maze over eight minutes.
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PMC9429973
Summary/Conclusion: Model projections show significant lifetime economic burden with severe SCD in the US, with per-patient cost estimates substantially higher than those previously published for the overall SCD population.
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PMC9429973
TP53 protein was positive in 15 patients, negative in 25 and not studied in 26.
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PMC8348645
This has become a recent trend in the last two decades in the field of the potential use and the application of traditional and herbal plants such as Andrographis paniculata, Centella asiatica, etc.
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PMC9599726
Emitted fluorescence was measured during the annealing–extension phase and amplification plots were generated using the sequence detection system.
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PMC9429973
In phase 1 Dose Escalation, patients with R/R AML or HR-MDS are treated with emavusertib monotherapy.
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PMC11539788
E-L) Correlation analyses of RNF19A expression and the expression levels of multiple genes in the mTOR signalling pathway, including EIF4EBP1, PGF, RPS6KB2, MLST8, PIK3CD, VEGFB, PIK3R5, and EIF4E2. (
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PMC11705547
In addition, acetyl-CoA produced by pyruvate is converted to malonyl-CoA. Using NADPH as a reducing cofactor, FASN catalyzes the synthesis of palmitic acid by acetyl-CoA and malonyl-CoA, which then synthesize FAs to participate in a variety of biological processes.
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PMC9812014
Following time-of-addition investigations, it was discovered that the antiviral action occurs after infection and is maintained after the drug is added until six hours after infection .
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PMC11672602
∗Significantly different from control animals (P < 0.05), Significantly different from positive control (P < 0.05), each group consists of six animals, Values expressed as Mean ± SEM.
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PMC11672617
Subsequently, the cells were seeded into 24-well plates at a density of 5 × 10 cells per well and incubated overnight.
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PMC11389534
The UFM1 system is an important regulatory mechanism that maintains ER homeostasis. , ,
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PMC7452526
A small concentration (5 μgmL) reduced the cell viability to 50% after 48h of exposure.
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PMC9429973
The differences were insignificant regarding the presence of FLT3 mutation or according to cytogenetics, FAB classification, gender, and age.
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PMC11627060
Our findings suggest that the apoptosis induced by TQ-BSA NPs in A549 cells may involve AIF release, along with mitochondrial membrane potential changes and modifications in Bax expression .
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PMC11703992
The MR estimates of the whole 6 significant exposures in training and validation datasets were presented in Fig. 4C, D. In detail, DDIT4 exhibited the association with GCA risk with an OR of 5.1065 (95% CI 1.5281–17.0645) via Wald Ratio method, while ARHGAP15 was associated with the risk of GCA with an OR of 1.2622 (95% CI 1.0159–1.5683) calculated via IVW and 1.1917 (95% CI 0.8675–1.6372) calculated via MR-Egger in training dataset, and the results were further validated in validation dataset.
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PMC10073922
Then, the effects of NDRG2 overexpression on viability, apoptosis, migration, and invasion of A549 cells were evaluated.
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PMC11347429
Furthermore, the samples here were collected on ‘day 1’ of a patient’s presentation at the hospital or the first blood draw from ICU patients.
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PMC10411253
In addition, varied differentiation of the coexisting Müllerian ducts might contribute in part to endocrinological abnormalities and infertility.
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PMC11787651
F, changes in the level of H3K9ac, an extremely low-level mark with an isomer complicating identification and quantification, are not consistently observed across the two methods.
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PMC9429973
Results: Our study included 189 treated patients who met eligibility criteria with a median follow up of 2 years.
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PMC11707832
α-Mannosidosis, an inherited metabolic disorder, exhibits characteristic cellular changes such as multiple membrane-bound cytoplasmic vacuoles found in various cell types—hepatocytes, pancreatic exocrine cells, renal cells, thyroid cells, smooth muscle cells, bone cells and neurons in the CNS and peripheral nervous system .
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PMC9429973
The primary endpoint is progression-free survival.
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PMC10926885
NDE1 physically binds to PAFAH1B1 and DCTN1, respectively.
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PMC11627133
Due to its best signal‐to‐background ratio, most compact predicted secondary structure and shortest sequence, AP3‐RhoBAST fused via the loop of RhoBAST (Figure S1A) was selected for all subsequent experiments.
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PMC11487720
In the knockout Wwox MEF cells, UV/cold shock did not cause the translocation of cytosolic TRAF2 to the nucleus in (Fig. 7C).
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PMC11317131
To our surprise, wildtype Bxb1 integrase had greater efficiency compared to evolved PhiC31 integrase mutants (Figure 4A).
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PMC11764090
It is necessary to explore the evaluation system to use future genetic methods to mine excellent cold tolerance genes, especially cold response genes specific to a single species.
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PMC7215832
Since treatment with DAC leads to hypomethylation and increased uptake of both PMX and MTX in CEM parental cells and its MTX-resistant variant , CEM/MTX, we used these cells to determine whether RX-3117 treatment would reactivate PCFT gene expression and mediated MTX uptake.
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PMC10565698
A complete medium (with 5 mL of fetal bovine serum in 45 mL of basal medium plus 0.5 mL of triple antibody) was used for cell culture.
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PMC9429973
Aims: We investigated the risk factors and outcomes in patients with FLT3-mutated AML that underwent alloHCT.
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PMC11754784
The time-depended macrophage-cancer cell interaction and phagocytosis were also recorded, indicating obvious phagocytosis caused by DNP3 treatment (Fig. 6g).
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PMC3730428
To directly prove that combined treatment with SAHA and AT-IAP/TNFα results in apoptosis induction rather than necroptosis, we cotreated cells with the pan-caspase inhibitor z-VAD-fmk and the necroptosis inhibitor Nec-1.
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PMC11411004
A t-test and one-way analysis of variance (ANOVA) were used for statistical analysis.
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PMC10933092
The quality of the RNAs was subsequently determined by measuring the OD260/OD280 value, and RNA purity was confirmed by measuring the OD260/OD230 value.
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PMC10976516
All these various combined factors make it very difficult to predict if enough OV particles can reach the tumor location after systemic infection.
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PMC6835428
This was mostly because uptake was evaluated just 4 h after treatment.
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PMC9429973
Aims: To evaluate whether tinostamustine enhances the anti-myeloma effect of daratumumab.
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PMC11190238
Perturbational single cell omics could serve as a useful tool in interrogation of diverse EMT regulation networks.
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PMC9429973
Aims: We aimed to profile circRNA expression in myelodysplastic syndrome (MDS), along with the related diseases chronic myelomonocytic leukemia (CMML) and clonal cytopenia of undetermined significance (CCUS), in order to identify disease-specific expression patterns and relevant candidates for biological or biomarker exploration.
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PMC11089031
The correction between ZNF692 and G3BP2 and TM9SF2 was analyzed by GEPIA web tools using TCGA KIRC dataset and tested by qPCR in ccRCC cells (A to E).
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PMC11588085
Brightfield images of OVCAR3-KRAB and SKOV3-KRAB clonal cell lines. (
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PMC9429973
Aims: The aim of the present study is to investigate the role of AHR and HIF-1α in the suppressive ability of Tregs during CLL development.
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PMC11674441
The increase in lymphocyte response was particularly marked for HLA class II-restricted neoantigens containing HLA class I affinity neoantigen epitopes.
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PMC11766350
For negative controls to be used in qPCR, pAAV-gfp-TRAIL was transfected in the same concentration used in triple transfection, but without the other plasmids.
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PMC9429973
Methods: A targeted sequencing gene panel including all exons and critical introns of 112 genes that are recurrently mutated in DLBCL was used for this study (Burning Rock Biotech Co. Ltd, Guangzhou, China).
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PMC9429973
It is a four-way Ph translocation t(1;9;12;22)(p35-36;q34;p13;q11) involving four chromosomal regions, 1p35-36, 9q34, 12p13 and 22q11.2.
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PMC11467964
To investigate enriched pathways and potential biological processes between the two distinct BM‐related clusters, we initiated GSVA enrichment analysis, revealing cluster A was markedly enriched in some oncogenic‐activated and immune‐activated pathways, such as bladder cancer, melanoma, NK cell‐mediated cytotoxicity, B cell receptor signaling pathway.
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PMC11519788
Ubiquitin-mediated protein degradation is a crucial mechanism that significantly influences cancer progression 13.
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PMC11290772
In brief, cells were suspended in the appropriate medium and seeded into a 96-well plate with a density of 1 × 10 cells per well.
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PMC10999934
More than that, Wang et al. reported patients with ovarian cancer who were to be in the high-risk category showed reduced sensitivity to chemotherapy medications .
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PMC9429973
Image: Summary/Conclusion: We conducted a pilot study investigating a novel method of early detection of NHL development in 36 patients at increased risk of hematological malignancy.
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PMC11562028
The UV spectra showed that there is no significant absorption peak in the Re solution.
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PMC11188874
The UBL domain mediates HR23B binding to proteasomes, which in turn enhances the delivery of ubiquitinylated cargo and promotes protein degradation.
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PMC9429973
Hypersensitivity affects the ability to maintain dose intensity which in turn results in poorer outcomes, especially if there is no suitable replacement.
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PMC11525293
Actin was used as the loading control, and one representative experiment is shown.
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PMC9429973
Mitochondrial activity arises as an important factor in the control of platelet reactivity and it could be critical in disease management and treatment strategies, specifically for the JAK2 V617F patients.
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PMC8382973
Reference microbial strains were purchased from ATCC, and a panel of probiotics strains, including Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus fermentium, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus delbrueckii subsp.
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PMC11281366
Furthermore, mutations in the CD59 3′ UTR sequences predicted to be targeted by miRNA-26a (Figure 4C, A+B-Mut) prevented the silencing effect on F-Luc (Figure 4D).
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PMC9351137
In a previous report, we have found that the ATPase SRCAP interacts with a plethora of cytokinesis regulators and positively controls their recruitment to the midbody .
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PMC8164677
The median effect analysis was done to determine combination index (CI).
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PMC5963610
Counterstaining with Mayer’s Hematoxylin (blue color).
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PMC10965315
To assess ROS production in the A2780 cells treated with harmaline, we used a 2′,7′‐dichlorodihydrofluorescein diacetate (DCFH2‐DA, #ab113851) assay kit.
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PMC11740207
The HE refers to the concept that human somatic cells can only divide a certain number of times before they cease to divide and enter senescence or undergo apoptosis.
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PMC11799978
Lowering the pH primes CAFs toward a mixed phenotype with increased expression of iCAF markers, including vimentin, αSMA, and FAP, increased expression of myCAF signature protein TGF-β, collagen I, and a-SMA, and increased expression of activated CAF markers such as CD49b, PDGFα and β, and CD95.
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PMC10291556
have also been designed and tested.
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PMC11705901
Site-directed mutagenesis was performed using the QuikChange site-directed mutagenesis kit (Stratagene, La Jolla, CA) according to manufacturer’s instructions.
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