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OTAR3088
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PMC5417661
The mitotic index (MI) was quantitated in a population of a minimum of 500 cells per treatment condition.
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PMC9429973
Results: As of 24 Feb 2022, no inhibitors were observed in total 69 enrolled patients with a median exposure of 332 days (range 79-432 days).
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PMC11143482
Furthermore, this cell line also has previously been found to be metastatic in an orthotopic model .
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PMC11577421
In vivo, albumin protects the endothelial glycocalyx against shedding, thereby playing a pivotal role in maintaining vascular integrity and permeability.
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PMC9712534
We assume that TOP2B H58Y may tend to pause in the TOP2 catalytic cycle under some circumstances in living cells.
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PMC11515150
The effector cells were co-cultured with target cells at various effector-to-target (E: T) ratios overnight.
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PMC9429973
Most reported hematologists manage the condition well (82%).
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PMC11720107
The process was carried out at 40 °C.
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PMC8041314
Hoechst 33342 and daunorubicin assays were conducted using either ABCB1-overexpressing A2780/ADR, ABCC1-overexpressing H69AR, or ABCG2-overexpressing MDCK II BCRP cells as reported earlier.
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PMC11297139
The white box highlights the organelle subjected to targeted bleaching.
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PMC11706491
Specifically, understanding how these reporters respond when cells enter the stationary phase or when they re-enter the cell cycle is essential for elucidating their dynamics beyond standard growth conditions.
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PMC11770130
Mendelian randomization studies use genetic variants that are associated with exposures to assess the causal associations of exposure with outcomes and aim to reduce bias from confounding and reverse causation.
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PMC11740573
Cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM) containing 2mM L-glutamine (Lonza, Switzerland), 5% fetal calf serum (Sigma-Aldrich, USA) and antibiotics: penicillin 100 UI/mL, streptomycin 100 UI/mL and neomycin 200 mg/mL (Sigma-Aldrich, USA).
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PMC6133382
Cultures were run until cell viability dropped below 50%.
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PMC8584319
3 × 10 MEFs were plated in 96-well plates a day before treatment with chemicals.
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PMC9952933
Unless otherwise stated, all data were depicted as mean values with standard deviation.
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PMC11087055
After manipulations (such as electroporation, inhibitor treatment, and implantation), the embryos were live-imaged on a vitelline membrane stretched around a glass ring according to the New culture method as previously described (New, 1955; Maya-Ramos and Mikawa, 2020).
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PMC7351993
The cell ID is received by the digital input of the FPGA boards.
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PMC11739504
To investigate the basal expression of Kat2b during cilium assembly, NIH/3T3 cells were exposed to serum starvation.
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PMC11791203
This facilitated the elucidation of the intricate interactions between the ligands and the apoptotic proteins, shedding light on their binding modes and affinities.
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PMC11472639
This study was supported by 10.13039/501100000289Cancer Research UK (Grant number: C60293/A28497).
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PMC9429973
Long non-coding RNAs (lncRNAs) have been recently described as key mediators in the development of hematological malignancies.
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PMC8839885
However, OC platinum sensitizing activity of fisetin and dasatinib were found to be ERK1/2 dependent, whereas the activity of 2HE2 was ERK1/2 independent.
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PMC10818573
The reaction time of step 1 of the common RPA reaction was set to 5, 10, 15, or 20 min, and step 2 was fixed at 15 min.
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PMC11585565
Furthermore, although the mutant CNNM4 proteins localize to the plasma membrane, their specific apical or basolateral membrane localization, crucial for their functional roles, requires clarification.
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PMC11699178
In this figure, we explored the interactions between HIF-1α, VEGF-B, and FGF2/FGFR1 by overexpressing these genes in human ovarian epithelial cells (ISOE-80).
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PMC9910796
In contrast, more than 90% of the vEP84Ri particles produced in the absence of IPTG were defective in terms of core shell and nucleoid organization in both areas.
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PMC6901583
Another factor is the nonresponsiveness of GISTs that lack such mutations to molecular targeted therapy.
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PMC10759659
c The difference in lymphocyte infiltration level by ssGSEA in the two groups.
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PMC8662250
Luckily, considering that the CBD concentration required (IC50) to inhibit CYP450 is significantly higher than the cannabidiol plasma concentration achieved by o.s. (
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PMC11429241
The scaffolds made from OrmoClear increased TWIST1 and CDH2’s expression while downregulating CDH1.
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PMC6160470
Each bar represents a mean value ± s.d.
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PMC11741577
Stimulated mast cells release various factors, including cytokines, histamine, and proteases .
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PMC11739504
Counted cell numbers were as follows: controls with serum starvation for 6 h, n = 685; 12 h, n = 665; 24 h, n = 589.
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PMC11790599
To generate lentivirus, HEK293T cells were seeded at 1 × 10 cells/well in 6-well plates and incubated overnight before being transfected with pLV2-CMV-Rab5A-mCherry/pLV3-CMV-Rab7-mCherry/pLV3-CMV-Rab11A-EGFP (0.5 μg), psPAX2 (0.375 μg) and pMG2.
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PMC6799808
β-Tubulin served as a loading control Numerous studies have shown that G. lucidum extracts exert anticancer effects.
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PMC11525028
Transfection of GFP 143B cells with siRNA was conducted following established methods at a final concentration of 20 nM for transcriptional.
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PMC11155445
MEP study of two novel acyl thiourea compounds (45 and 46) show that the negative potential of molecule localized on N of nitrile group, S and O of thiocarbonyl and carbonyl group, while positive potential localized on hydrogen atoms (N1–H1A, N2–H2A) of the urea moiety and hydrogen atoms of phenyl group.
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PMC11739484
The formula for the prognostic model of SKCM patients’ prognosis was defined as the risk score, which was calculated as the sum of the multivariate Cox regression coefficient variation of each mRNA.
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PMC4839679
Thus, other factors are required to drive ccRCC progression.
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PMC11803149
Age-related CD8 T-cell-intrinsic changes are sufficient to impair their anti-tumor responses after adoptive transfer into young recipient mice.
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PMC11741906
Overall, four upregulated miRNAs were associated with worse survival in patients diagnosed with ovarian cancer.
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PMC11001582
Although most of these mouse models recapitulate features of C9ALS/FTD, there is considerable phenotypic variation between them, possibly from site of integration, which may cause local mutation, copy number or other effects.
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PMC11407042
The relative cytotoxicity of ΔfleR and ΔfleR(fleR) strains compared to the PAO1 wild-type strain.
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PMC10743717
Deacetylation of 17β-HSD10 by sirtuins helps regulate its catalytic activities.
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PMC10858941
The dimensions of the device are 4 × 2 mm central chamber, 0.7 mm lateral channel width, 250 µm height.
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PMC11544122
b CXCR4 endocytosis was examined in HEK293 cells transfected with FLAG-tag WT, 4A, or 5A receptors.
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PMC2777936
NT2/D1, NT2/D1-R1, Tera-1, 833K and 293T human cells were cultured in high glucose DMEM (InVitrogen, CA) containing 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mM glutamine, and 10% fetal bovine serum (FBS) at 37°C under humidified 5% CO2.
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PMC11306331
We hypothesized that a protein containing multiple FUS sequences would condense without the need for additional oligomerization domains, forming a simple IDR-driven constitutive condensate in cells.
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PMC10142392
For example, experimental evidence has shown that for PEG-based systems, copolymers form spherical micelles with a PEG volumetric fraction (f) > 50%, cylindrical micelles with 40% < f < 50%, and vesicles with 25% < f < 40%.
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PMC7022782
Recently, we demonstrated that newly synthesized poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NPs) are possible antitumor agents due to their cytotoxicity for cancer cells.
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PMC11271800
This also implies that the inflammatory response can respond to different tumor stages, whereas a large number of M2 TAMs suppresses the inflammatory response and also largely predict tumor progression.
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PMC9429973
Prior to initial RUX treatment, 57% of pts had a diagnosis of splenomegaly, 56% had anemia, 25% had thrombocytopenia, 19% had received RBC transfusion, and 7% had neutropenia.
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PMC11772449
the expression level of FLAG-p38γ was detected by western blot. (
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PMC11674441
All patients underwent curative surgery for breast cancer before the study.
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PMC9429973
To discuss the cases in which findings at dental assessment resulted in significant delay to HSCT.
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PMC5415764
Our result was opportune in accordance with the molar ratio (1/1) of PLGA and PTX in this conjugate.
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PMC11449273
Additionally, plakoglobin may directly regulate the activation of certain genes, such as PUMA and BAX (S4 Fig).
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PMC9844987
This is particularly apparent for CpG islands, which seem to have an attenuating effect on promoter variability regardless of expression level (Figure 2F).
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PMC11568601
Loading buffer (ABclonal Biotech.,
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PMC11337594
Total RNA was isolated from A375 cells using TRIzol reagent (R401-01#, Vazyme, Nanjing, China).
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PMC11720808
Illustration of the in vivo mouse xenograft experiment. (
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PMC9512971
Efficacy evaluations were not conducted after confirmation of SARS-CoV-2 negativity.
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PMC6222635
In addition, the anti-tumor activity was tested via MTT assays.
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PMC11787381
p < 0.05 vs. AβO condition (red) (one-way ANOVA followed by PLSD Fisher’s test).
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PMC11594641
Knockout cells appeared to release smaller particles than WT SkMel28; however, the difference did not reach statistical significance (p = 0.25).
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PMC9966931
4-Allyl-2-methoxyphenyl benzoate —Colorless crystals.
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PMC11704834
no. CRL 2868) were obtained from the American Type Culture Collection.
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PMC11206251
Carbon tetrachloride was added after standing at room temperature for 5 min.
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PMC11499381
We also tested calcitonin as an agonist at CTR alone, as it is more potent than αCGRP at this receptor.
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PMC9516447
Next day, the cells were transfected with siRNAs targeting GRP78 (si78) or scrambled control (siCtrl) using the Lipofectamine RNAiMAX Transfection Reagent (ThermoFisher Scientific, Waltham, MA, Cat# 13778075) in accordance with manufacturer's recommendation for forward transfection.
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PMC7812570
In view of this, we think that it is critical to characterize bNAbs for generating HIV-resistant cells.
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PMC11730305
Flow cytometry analysis (a) control and (b) Co3O4@Glu- Ellagic acid NPs treated cancer cells.
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PMC11173119
This qPCR kit determines 20 mutations, which have been identified in exon 1 (E84K), in exon 2 (L110P, E148Q, E148V, E167D, E230K/Q, T267I, P283L, G304R), in exon 3 (P369S), in exon 5 (F479L), and in exon 10 (M680I (G/C-A), M694I, M694V, K695R, V726A, A744S, R761H) covering 99.2% of the mutation rate of FMF in the Anatolian, Middle East and many other countries.
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PMC11740207
In in vitro AML experiments where cells are cultured in medium at low cell density, proliferating HL60 cells have been observed to regenerate through very small and small cell stages.
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PMC7802142
Data are expressed as mean ± SEM.
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PMC3019555
This result indicated that the TX-induced suppression of HIF-1α requires the presence of HIF’s UTRs.
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PMC3019555
Protein quantification was performed using Odyssey (version 2.1) and ImageJ (National Institutes of Health) software.
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PMC8753818
It is worth mentioning that controlling cell proliferation by manipulating cell cycle in recombinant cell lines is in the context of biotechnology and leads to an increase in the expression of heterologous proteins.
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PMC11655536
This is consistent with the role of HA to alter pHi and inhibit cell growth in AML .
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PMC3730428
Although, TNFR1 complex IIb can induce programmed necrosis (necroptosis) under certain conditions (for example, if FLIP(S) is recruited rather than FLIP(L)), we found that the mechanism of cell death induced when either FLIP splice form was downregulated in TNFα and SMC cotreated mesothelioma cells was apoptotic.
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PMC11786156
The OD at 570 nm suggested that the amount of HBL-2 cell adhesion was significantly higher in the 10 μg/mL and 100 μg/mL wells than in the 0 μg/mL wells (Figure 4c).
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PMC9429973
Summary/Conclusion: At the stage of MGUS, disturbances in the processes of bone tissue remodeling occur, which is accompanied by the appearance of deviations in the level of biochemical markers (osteocalcin, β CrossLaps).
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PMC11777207
Using a ruler acquired at the same magnification and the measurement tool in Adobe Photoshop, the epidermis was measured.
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PMC11468365
Finally, the synergy and sensitivity scores are output by learning two fully connected (FC) subnetworks.
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PMC9351137
Moreover, midbody alterations cause cytokinesis failure and result in (1) inhibition or regression of the cleavage furrow, with the ensuing formation of binucleated cells, or (2) persistence of connections between daughter cells, with the formation of long intercellular bridges originating syncytial cells.
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PMC9429973
Methods: In a context of a clinical trial (approved by the ethical Committee of the Faculty of Medicine Mansoura University), eligible denovo patients of CML chronic phase (N=26) were treated with imatinib 400 mg combined and pioglitazone 15 mg (off label use) daily for 6 months after having their consent.
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PMC11802855
However, subcutaneous soft tissue metastatic foci were identified in the mice of the OE group, but not in those of the NC group.
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PMC8143558
Khanna and Khannabiran reported that Aspergillus niger and Aspergillus flavus were inhibited by the saponin extract from the roots of Hemidesmus indicus (L.) R. Br.
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PMC11047729
Homoharringtonine (HHT) is a substance derived from the Chinese evergreen Cephalotaxus harringtonia and exhibits antitumor activity.
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PMC10975211
The carrier choice depends on the bioconjugate’s desired properties, including stability, release profile, and targeting ability.
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PMC10873328
After transfected with HIF-1α, the mRNA levels of the four genes were insignificantly changed, indicating that the four genes were not HIF-1α-responsive (Fig. 2c).
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PMC9429973
Additionally, the statistically significant effects of these genotypes on survival were examined.
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PMC11774112
Tumor weights of mice receiving different therapeutic regimens (n =6, mean ± SD). (
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PMC10878518
By contrast, benign tumors showed no significant increase in GFP expression between 24 and 48 h after OBP-401 infection regardless of CAR and hTERT expressions (Fig 5C and 5D).
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PMC4355729
Horseradish peroxidase (HRP) labelled secondary antibody (Beyotime Biotech) was used in western blots.
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PMC10165258
The results of the experiment are presented in Figure 5C, where each heatmap represents the mean viability per drug concentration in one single time point after drug addition.
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PMC9429973
LP-108 is orally administered once daily in 28-day cycles until disease progression, unacceptable toxicity, or per investigator discretion.
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PMC10530622
In addition to p.G170R, p.G41R, p.F152I and p.I244T are also considered minor alleles requiring (MiR) variants.
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PMC7841189
Knockdown of LTBP2 greatly increased the level of the epithelial marker (E-cadherin) and suppressed the levels of the mesenchymal markers (N-cadherin and vimentin) (Fig. 4).
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