Abstract:
A method of prognosticating metastasis in a breast cancer patient involves identifying differential modulation of each gene (relative to the expression of the same genes in a normal population) in a combination of genes selected from a group consisting of genes.  
     Gene expression portfolios and kits for employing the method are further aspects of the invention.

Description:
[0001]    This application claims the benefit of U.S. Provisional Application No. 60/368,789 filed on Mar. 29, 2002. 
     
    
     
       BACKGROUND  
         [0002]    The invention relates to the selection of portfolios of diagnostic markers.  
           [0003]    A few single gene diagnostic markers such as her-2-neu are currently in use. Usually, however, diseases are not easily diagnosed with molecular diagnostics for one particular gene. Multiple markers are often required and the number of such markers that may be included in a assay based on differential gene modulation can be large, even in the hundreds of genes. It is desirable to group markers into portfolios so that the most reliable results are obtained using the smallest number of markers necessary to obtain such a result. This is particularly true in assays that contain multiple steps such as nucleic acid amplification steps.  
         SUMMARY OF THE INVENTION  
         [0004]    The invention is a method of prognosticating metastasis in a breast cancer patient by identifying differential modulation of each gene (relative to the expression of the same genes in a normal population) in a combination of genes selected from the group consisting of Seq. ID. No. 70-97.  
           [0005]    Gene expression portfolios and kits for employing the method are further aspects of the invention.  
         DETAILED DESCRIPTION  
         [0006]    The methods of this invention can be used in conjunction with any method for determining the gene expression patterns of relevant cells as well as protein based methods of determining gene expression. Preferred methods for establishing gene expression profiles include determining the amount of RNA that is produced by a gene that can code for a protein or peptide. This is accomplished by reverse transcriptase PCR (RT-PCR), competitive RT-PCR, real time RT-PCR, differential display RT-PCR, Northern Blot analysis and other related tests. While it is possible to conduct these techniques using individual PCR reactions, it is best to amplify copy DNA (cDNA) or copy RNA (cRNA) produced from mRNA and analyze it via microarray. A number of different array configurations and methods for their production are known to those of skill in the art and are described in U.S. Pat. Nos. such as: 5,445,934; 5,532,128; 5,556,752; 5,242,974; 5,384,261; 5,405,783; 5,412,087; 5,424,186; 5,429,807; 5,436,327; 5,472,672; 5,527,681; 5,529,756; 5,545,531; 5,554,501; 5,561,071; 5,571,639; 5,593,839; 5,599,695; 5,624,711; 5,658,734; and 5,700,637; the disclosures of which are incorporated herein by reference.  
           [0007]    Microarray technology allows for the measurement of the steady-state mRNA level of thousands of genes simultaneously thereby presenting a powerful tool for identifying effects such as the onset, arrest, or modulation of uncontrolled cell proliferation. Two microarray technologies are currently in wide use. The first are cDNA arrays and the second are oligonucleotide arrays. Although differences exist in the construction of these chips, essentially all downstream data analysis and output are the same. The product of these analyses are typically measurements of the intensity of the signal received from a labeled probe used to detect a cDNA sequence from the sample that hybridizes to a nucleic acid sequence at a known location on the microarray. Typically, the intensity of the signal is proportional to the quantity of cDNA, and thus mRNA, expressed in the sample cells. A large number of such techniques are available and useful. Preferred methods for determining gene expression can be found in U.S. Pat. Nos. 6,271,002 to Linsley, et al.; 6,218,122 to Friend, et al.; 6,218,114 to Peck, et al.; and 6,004,755 to Wang, et al., the disclosure of each of which is incorporated herein by reference.  
           [0008]    Analysis of the expression levels is conducted by comparing such intensities. This is best done by generating a ratio matrix of the expression intensities of genes in a test sample versus those in a control sample. For instance, the gene expression intensities from a diseased tissue can be compared with the expression intensities generated from normal tissue of the same type (e.g., diseased colon tissue sample vs. normal colon tissue sample). A ratio of these expression intensities indicates the fold-change in gene expression between the test and control samples.  
           [0009]    Modulated genes are those that are differentially expressed as up regulated or down regulated in non-normal cells. Up regulation and down regulation are relative terms meaning that a detectable difference (beyond the contribution of noise in the system used to measure it) is found in the amount of expression of the genes relative to some baseline. In this case, the baseline is the measured gene expression of a normal cell. The genes of interest in the non-normal cells are then either up regulated or down regulated relative to the baseline level using the same measurement method.  
           [0010]    Preferably, levels of up and down regulation are distinguished based on fold changes of the intensity measurements of hybridized microarray probes. For example, in the case in which a 1.5 fold or more difference is used to make such distinctions, the diseased cell is found to yield at least 1.5 times more, or 1.5 times less intensity than the normal cells.  
           [0011]    Other methods of making distinctions are available. For example, statistical tests can be used to find the genes most significantly different between diverse groups of samples. The Student&#39;s t-test is an example of a robust statistical test that can be used to find significant differences between two groups. The lower the p-value, the more compelling the evidence that the gene is showing a difference between the different groups. Nevertheless, since microarrays measure more than one gene at a time, tens of thousands of statistical tests may be asked at one time. Because of this, there is likelihood to see small p-values just by chance and adjustments for this using a Sidak correction as well as a randomization/permutation experiment can be made.  
           [0012]    A p-value less than 0.05 by the t-test is evidence that the gene is significantly different. More compelling evidence is a p-value less then 0.05 after the Sidak correct is factored in. For a large number of samples in each group, a p-value less than 0.05 after the randomization/ permutation test is the most compelling evidence of a significant difference.  
           [0013]    Genes can be grouped so that information obtained about the set of genes in the group provides a sound basis for making clinically relevant judgments such as a diagnosis, prognosis, or treatment choice. These sets of genes make up the portfolios of the invention. As with most diagnostic markers, it is often desirable to use the fewest number of markers sufficient to make a correct medical judgment. This prevents a delay in treatment pending further analysis as well as inappropriate use of time and resources. Preferred optimal portfolio is one that employs the fewest number of markers for making such judgments while meeting conditions that maximize the probability that such judgments are indeed correct. These conditions will generally include sensitivity and specificity requirements. In the context of microarray based detection methods, the sensitivity of the portfolio can be reflected in the fold differences exhibited by a gene&#39;s expression in the diseased or aberrant state relative to the normal state. The detection of the differential expression of a gene is sensitive if it exhibits a large fold change relative to the expression of the gene in another state. Another aspect of sensitivity is the ability to distinguish signal from noise. For example, while the expression of a set of genes may show adequate sensitivity for defining a given disease state, if the signal that is generated by one (e.g., intensity measurements in microarrays) is below a level that easily distinguished from noise in a given setting (e.g., a clinical laboratory) then that gene should be excluded from the optimal portfolio. A procedure for setting conditions such as these that define the optimal portfolio can be incorporated into the inventive methods.  
           [0014]    Specificity can be reflected in statistical measurements of the correlation of the signaling of gene expression with the condition of interest. If the differential expression of a set of genes is observed to produce a large fold change but they do so for a number of conditions other than the condition of interest (e.g. multiple disease states) then the gene expression profile for that set of genes is non-specific. Statistical measurements of correlation of data or the degree of consistency of data such as standard deviation, correlation coefficients, and the like can be a used as such measurements. In considering a group of genes for inclusion in a portfolio, a small standard deviation in expression measurements correlates with greater specificity. Genes that display similar expression patterns may be co-regulated by an identical factor that pushes the genes in the same direction. If this factor is sufficient but not necessary for classifying a sample, then these genes will fail to correctly identify a sample if the markers are all related to this single factor. Diversification then results in selecting as few markers as possible, yet covers as many different optimal expression patterns that are contained in the data set  
           [0015]    In the method of the invention, a group of genetic markers is selected for use in diagnostic applications. These groups of markers are “portfolios”. Diagnostic applications include the detection or identification of a disease state or condition of a subject, determining the likelihood that a subject will contract a given disease or condition, determining the likelihood that a subject with a disease or condition will respond to therapy, determining the prognosis of a subject with a disease or condition (or its likely progression or regression), and determining the effect of a treatment on a subject with a disease or condition. For example, the method can be used to establish portfolios for detecting the presence or likelihood of a subject contracting colon cancer or the likelihood that such a subject will respond favorably to cytotoxic drugs.  
           [0016]    The portfolios selected by the method of the invention contain a number and type of markers that assure accurate and precise results and are economized in terms of the number of genes that comprise the portfolio. The method of the invention can be used to establish optimal gene expression portfolios for any disease, condition, or state that is concomitant with the expression of multiple genes. An optimal portfolio in the context of the instant invention refers to a gene expression profile that provides an assessment of the condition of a subject (based upon the condition for which the analysis was undertaken) according to predetermined standards of at least two of the following parameters: accuracy, precision, and number of genes comprising the portfolio.  
           [0017]    Most preferably, the markers employed in the portfolio are nucleic acid sequences that express mRNA (“genes”). Expression of the markers may occur ordinarily in a healthy subject and be more highly expressed or less highly expressed when an event that is the object of the diagnostic application occurs. Alternatively, expression may not occur except when the event that is the object of the diagnostic application occurs.  
           [0018]    Marker attributes, features, indicia, or measurements that can be compared to make diagnostic judgments are diagnostic parameters used in the method. Indicators of gene expression levels are the most preferred diagnostic parameters. Such indicators include intensity measurements read from microarrays, as described above. Other diagnostic parameters are also possible such as indicators of the relative degree of methylation of the markers.  
           [0019]    Distinctions are made among the diagnostic parameters through the use of mathematical/statistical values that are related to each other. The preferred distinctions are mean signal readings indicative of gene expression and measurements of the variance of such readings. The most preferred distinctions are made by use of the mean of signal ratios between different group readings (e.g., microarray intensity measurements) and the standard deviations of the signal ratio measurements. A great number of such mathematical/statistical values can be used in their place such as return at a given percentile.  
           [0020]    A relationship among diagnostic parameter distinctions is used to optimize the selection of markers useful for the diagnostic application. Typically, this is done through the 25 use of linear or quadratic programming algorithms. However, heuristic approaches can also be applied or can be used to supplement input data selection or data output. The most preferred relationship is a mean-variance relationship such as that described in  Mean-Variance Analysis in Portfolio Choice and Capital Markets  by Harry M. Markowitz (Frank J. Fabozzi Associates, New Hope, PA: 2000, ISBN: 1-883249-75-9) which is incorporated herein by reference. The relationship is best understood in the context of the selection of stocks for a financial investment portfolio. This is the context for which the relationship was developed and elucidated.  
           [0021]    The investor looking to optimize a portfolio of stocks can select from a large number of possible stocks, each having a historical rate of return and a risk factor. The mean variance method uses a critical line algorithm of linear programming or quadratic programming to identify all feasible portfolios that minimize risk (as measured by variance or standard deviation) for a given level of expected return and maximize expected return for a given level of risk. When standard deviation is plotted against expected return an efficient frontier is generated. Selection of stocks along the efficient frontier results in a diversified stock portfolio optimized in terms of return and risk.  
           [0022]    When the mean variance relationship is used in the method of the instant invention, diagnostic parameters such as microarray signal intensity and standard deviation replace the return and risk factor values used in the selection of financial portfolios. Most preferably, when the mean variance relationship is applied, a commercial computer software application such as the “Wagner Associates Mean-Variance Optimization Application”, referred to as “Wagner Software” throughout this specification. This software uses functions from the “Wagner Associates Mean-Variance Optimization Library” to determine an efficient frontier and optimal portfolios in the Markowitz sense. Since such applications are made for financial applications, it may be necessary to preprocess input data so that it can conform to conventions required by the software. For example, when Wagner Software is employed in conjunction with microarray intensity measurements the following data transformation method is employed.  
           [0023]    A relationship between each genes baseline and experimental value must first be established. The preferred process is conducted as follows. A baseline class is selected. Typically, this will comprise genes from a population that does not have the condition of interest. For example, if one were interested in selecting a portfolio of genes that are diagnostic for breast cancer, samples from patients without breast cancer can be used to make the baseline class. Once the baseline class is selected, the arithmetic mean and standard deviation is calculated for the indicator of gene expression of each gene for baseline class samples. This indicator is typically the fluorescent intensity of a microarray reading. The statistical data computed is then used to calculate a baseline value of (X*Standard Deviation+Mean) for each gene. This is the baseline reading for the gene from which all other samples will be compared. X is a stringency variable selected by the person formulating the portfolio. Higher values of X are more stringent than lower. Preferably, X is in the range of 0.5 to 3 with 2 to 3 being more preferred and 3 being most preferred.  
           [0024]    Ratios between each experimental sample (those displaying the condition of interest) versus baseline readings are then calculated. The ratios are then transformed to base 10 logarithmic values for ease of data handling by the software. This enables down regulated genes to display negative values necessary for optimization according to the Markman mean-variance algorithm using the Wagner Software.  
           [0025]    The preprocessed data comprising these transformed ratios are used as inputs in place of the asset return values that are normally used in the Wagner Software when it is used for financial analysis purposes.  
           [0026]    Once an efficient frontier is formulated, an optimized portfolio is selected for a given input level (return) or variance that corresponds to a point on the frontier. These inputs or variances are the predetermined standards set by the person formulating the portfolio. Stated differently, one seeking the optimum portfolio determines an acceptable input level (indicative of sensitivity) or a given level of variance (indicative of specificity) and selects the genes that lie along the efficient frontier that correspond to that input level or variance. The Wagner Software can select such genes when an input level or variance is selected. It can also assign a weight to each gene in the portfolio as it would for a stock in a stock portfolio.  
           [0027]    Determining whether a sample has the condition for which the portfolio is diagnostic can be conducted by comparing the expression of the genes in the portfolio for the patient sample with calculated values of differentially expressed genes used to establish the portfolio. Preferably, a portfolio value is first generated by summing the multiples of the intensity value of each gene in the portfolio by the weight assigned to that gene in the portfolio selection process. A boundary value is then calculated by (Y*standard deviation+mean of the portfolio value for baseline groups) where Y is a stringency value having the same meaning as X described above. A sample having a portfolio value greater than the boundary value of the baseline class is then classified as having the condition. If desired, this process can be conducted iteratively in accordance with well known statistical methods for improving confidence levels.  
           [0028]    Optionally one can reiterate this process until best prediction accuracy is obtained.  
           [0029]    The process of portfolio selection and characterization of an unknown is summarized as follows:  
           [0030]    1. Choose baseline class  
           [0031]    2. Calculate mean, and standard deviation of each gene for baseline class samples  
           [0032]    3. Calculate (X*Standard Deviation+Mean) for each gene. This is the baseline reading from which all other samples will be compared. X is a stringency variable with higher values of X being more stringent than lower.  
           [0033]    4. Calculate ratio between each Experimental sample versus baseline reading calculated in step 3.  
           [0034]    5. Transform ratios such that ratios less than 1 are negative (eg.using Log base 10). (Down regulated genes now correctly have negative values necessary for MV optimization).  
           [0035]    6. These transformed ratios are used as inputs in place of the asset returns that are normally used in the software application.  
           [0036]    7. The software will plot the efficient frontier and return an optimized portfolio at any point along the efficient frontier.  
           [0037]    8. Choose a desired return or variance on the efficient frontier.  
           [0038]    9. Calculate the Portfolio&#39;s Value for each sample by summing the multiples of each gene&#39;s intensity value by the weight generated by the portfolio selection algorithm.  
           [0039]    10. Calculate a boundary value by adding the mean Portfolio Value for Baseline groups to the multiple of Y and the Standard Deviation of the Baseline&#39;s Portfolio Values. Values greater than this boundary value shall be classified as the Experimental Class.  
           [0040]    11. Optionally one can reiterate this process until best prediction accuracy is obtained.  
           [0041]    A second portfolio can optionally be created by reversing the baseline and experimental calculation. This creates a new portfolio of genes which are up-regulated in the original baseline class. This second portfolio&#39;s value can be subtracted from the first to create a new classification value based on multiple portfolios.  
           [0042]    Another useful method of pre-selecting genes from gene expression data so that it can be used as input for a process for selecting a portfolio is based on a threshold given by  
         1   ≤            (       μ   t     -     μ   n       )       (       σ   t     +     σ   n       )              ,                         
 
           [0043]    , where μ t  is the mean of the subset known to possess the disease or condition, μ n  is the mean of the subset of normal samples, and σ t +σ n  represent the combined standard deviations. A signal to noise cutoff can also be used by pre-selecting the data according to a relationship such as  
       0.5   ≤              (       μ   t     -     MAX   n       )       (       σ   t     +     σ   n       )            .                           
 
           [0044]    . This ensures that genes that are pre-selected based on their differential modulation are differentiated in a clinically significant way. That is, above the noise level of instrumentation appropriate to the task of measuring the diagnostic parameters. For each marker pre-selected according to these criteria, a matrix is established in which columns represents samples, rows represent markers and each element is a normalized intensity measurement for the expression of that marker according to the relationship:  
              (       μ   t     -   I     )       μ   t                                
 
           [0045]    where I is the intensity measurement.  
           [0046]    Using this process of creating input for financial portfolio software make also allows one to set additional boundary conditions to define the optimal portfolios. For example, portfolio size can be limited to a fixed range or number of markers. This can be done either by making data pre-selection criteria more stringent (e.g,.  
       .8   ≤            (       μ   t     -     MAX   n       )       (       σ   t     +     σ   n       )                                  
 
           [0047]    instead of  
         0.5   ≤            (       μ   t     -     MAX   n       )       (       σ   t     +     σ   n       )              )                         
 
           [0048]    or by using programming features such as restricting portfolio size. One could, for example, set the boundary condition that the efficient frontier is to be selected from among only the optimal 10 genes. One could also use all of the genes pre-selected for determining the efficient frontier and then limit the number of genes selected (e.g., no more than 10).  
           [0049]    The process of selecting a portfolio can also include the application of heuristic rules. Preferably, such rules are formulated based on biology and an understanding of the technology used to produce clinical results. More preferably, they are applied to output from the optimization method. For example, the mean variance method of portfolio selection can be applied to microarray data for a number of genes differentially expressed in subjects with breast cancer. Output from the method would be an optimized set of genes that could include some genes that are expressed in peripheral blood as well as in diseased breast tissue. If sample used in the testing method are obtained from peripheral blood and certain genes differentially expressed in instances of breast cancer could also be differentially expressed in peripheral blood, then a heuristic rule can be applied in which a portfolio is selected from the efficient frontier excluding those that are differentially expressed in peripheral blood. Of course, the rule can be applied prior to the formation of the efficient frontier by, for example, applying the rule during data pre-selection.  
           [0050]    Other heuristic rules can be applied that are not necessarily related to the biology in question. For example, one can apply the rule that only a given percentage of the portfolio can be represented by a particular gene or genes. Commercially available software such as the Wagner Software readily accommodates these types of heuristics. This can be useful, for example, when factors other than accuracy and precision (e.g., anticipated licensing fees) have an impact on the desirability of including one or more genes.  
           [0051]    Other relationships aside from the mean-variance relationship can be used in the method of the invention provided that they optimize the portfolio according to predetermined attributes such as assay accuracy and precision. Two examples are the Martin simultaneous equation approach (Elton, Edwin J. and Martin J. Gruber (1987),  Modern Portfolio Theory Investment Analysis , Third Edition, John Wiley, New York, 1987) and Genetic Algorithms (Davis, L., (1989),  Adapting Operator Probabilities in Genetic Algorithms , in  Proceedings of the Third International Conference on Genetic Algorithms , Morgan Kaufmann: San Mateo, pp. 61-69). There are also many ways to adapt the mean-variance relationship to handle skewed data such as where a marker detection technology exhibits a known bias. These include, for example, the Semi-Deviation method in which the square root of the average squared (negative) deviation from a reference signal and includes only those signal values that fall below the reference signal.  
           [0052]    Articles of this invention include representations of the gene expression profiles that make up the portfolios useful for treating, diagnosing, prognosticating, and otherwise assessing diseases. These representations are reduced to a medium that can be automatically read by a machine such as computer readable media (magnetic, optical, and the like). The articles can also include instructions for assessing the gene expression profiles in such media. For example, the articles may comprise a CD ROM having computer instructions for comparing gene expression profiles of the portfolios of genes described above. The articles may also have gene expression profiles digitally recorded therein so that they may be compared with gene expression data from patient samples. Alternatively, the profiles can be recorded in different representational format. A graphical recordation is one such format.  
           [0053]    Different types of articles of manufacture according to the invention are media or formatted assays used to reveal gene expression profiles. These can comprise, for example, microarrays in which sequence complements or probes are affixed to a matrix to which the sequences indicative of the genes of interest combine creating a readable determinant of their presence. When such a microarray contains an optimized portfolio great savings in time, process steps, and resources are attained by minimizing the number of cDNA or oligonucleotides that must be applied to the substrate, reacted with the sample, read by an analyzer, processed for results, and (sometimes) verified.  
           [0054]    Other articles according to the invention can be fashioned into reagent kits for conducting hybridization, amplification, and signal generation indicative of the level of expression of the genes in the portfolios established through the method of the invention. Kits made according to the invention include formatted assays for determining the gene expression profiles. These can include all or some of the materials needed to conduct the assays such as reagents and instructions. 
       
    
    
     EXAMPLES  
     Example 1  
       [0055]    Producing an Optimized Portfolio  
         [0056]    Gene expression data was recently produced from tissue samples representative of eleven different types of cancers. The data was published in  Cancer Research  61: 7388-7393, 2001 and http://carrier.gnf.org/welsh/epican/. See, Andrew I. Su et al., “Molecular Classification of Human Carcinomas by Use of Gene Expression Signatures.” The data included intensity measurements obtained with the use of an “U95” a oligonucleotide microarray (commercially available from Affymetrix, Inc.).  
         [0057]    Measurements of the expression of genes from the published data (fluorescent intensity measurements) was used to select optimum gene expression portfolios for a panel of markers to determine whether a circulating cell is indicative of the presence of breast cancer, prostate cancer, ovarian cancer, colorectal cancer, or lung cancer. Such circulating cells would preferably be epithelial cells.  
         [0058]    The data in the study was collected from the following samples: 24 adenocarcinomas, 12 infilitrating ductal breast adenocarcenomas, 21 colorectal adenocarcinomas, 23 ovarian adenocarcinomas, 25 lung carcinomas, and data from the following additional samples: 19 prostate adenocarcinomas, 12 breast carinomas, 13 colon carcinomas, 13 ovarian carcinomas, 13 ovarian carcinomas, and 89 lung carcenomas.  
         [0059]    Using intensity readings from a collection of normal samples as the baseline class, the arithmetic mean, and standard deviation of each gene were calculated followed by a calculation of the value (X*Standard Deviation+Mean) for each gene. The stringency variable, X, was assigned a value of 3 in this case. Ratios were then calculated between each Experimental sample described in the study versus the baseline value calculations. The ratios were transformed into common logarithms. These values were then used as the input values for the Wagner Software.  
         [0060]    This procedure selected an efficient frontier along which a minimum set of markers for each tumor type that have the lowest amount of variation for a selected level of differential (chosen at the best signal to noise ratio point). Optimization by the software resulted in the selection of a portfolio of 24 genes including 2 for prostate cancer, 5 for breast cancer, 6 for colon cancer, 2 for ovarian cancer, and 9 for lung cancer markers (Table 1).  
                                                     TABLE 1                       Cancer                       Type   Accession   Name   Description   Seq, ID No.                                PR   NM_001648   KLK3   kallikrein 3, (prostate specific antigen)   Seq. ID No. 1       PR   NM_005551   KLK2   kallikrein 2, prostatic   Seq. ID No. 2       BR   NM_004064   CDKN1B   cyclin-dependent kinase inhibitor 1B (p27, Kip1)   Seq. ID No. 34       BR   NM_002411   MGB1   mammaglobin 1   Seq. ID No. 3       BR   NM_005264   GFRA1   GDNF family receptor alpha 1   Seq. ID No. 4       BR   none   C18ORF1   chromosome 18 open reading frame 1   Seq. ID No. 98       BR   NM_000095   COMP   cartilage oligomeric matrix protein   Seq. ID No. 6       CO   NM_001804   CDX1   caudal type homeo box transcription factor 1   Seq. ID No. 8       CO   NM_001046   SLC12   solute carrier family 12 (sodium/potassium/chloride   Seq. ID No. 9               A2   transporters), member 2       CO   NM_001285   CLCA1   chloride channel, calcium activated, family member 1   Seq. ID No. 11       CO   NM_007052   NOX1   NADPH oxidase 1   Seq. ID No. 13       CO   NM_002457   MUC2   mucin 2, intestinal/tracheal   Seq. ID No. 14       CO   NM_004063   CDH17   cadherin 17, LI cadherin   Seq. ID No. 15       LU_A   NM_021950   MS4A2   membrane-spanning 4-domains, subfamily A, member 2   Seq. ID No. 17       LU_A   NM_000964   ASAHL   N-acylsphingosine amidohydrolase (acid ceramidase)-like   Seq. ID No. 18       LU_A   NM_006495   EVI2B   ecotropic viral integration site 2B   Seq. ID No. 20       LU_A   NM_006864   LILRB3   leukocyte immunoglobulin-like receptor, subfamily B   Seq. ID No. 21       LU_A   X67301   None   H.sapiens mRNA for lgM heavy chain constant region(AB63)   Seq. ID No. 22       LU_A   NM_002123   HLA-DQB1   major histocompatibility complex, class II, DQ beta 1   Seq. ID No. 23       LU_S   NM_000673   ADH7   alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide   Seq. ID No. 24       LU_S   NM_003722   TP63   tumor protein 63 kDa with strong homology to p53   Seq. ID No. 26       LU_S   none   SOX2   SRY (sex determining region Y)-box 2   Seq. ID No. 32       OV   NM_000906   NPR1   natriuretic peptide receptor A/guanylate cyclase A   Seq. ID No. 28       OV   NM_000378   WT1   Wilms tumor 1   Seq. ID No. 30                  
 
       Example 2  
       [0061]    Heuristic Step  
         [0062]    A heuristic rule was further applied to the portfolio obtained in Example 1. That is, the rule stated that if the gene/marker identified would likely be expressed in peripheral blood or were well-characterized tissue markers (e.g. PSA, mammaglobin, etc.), then such genes/marker would be removed from the portfolio. Application of the rule enabled the establishment of a portfolio of genes/markers that are optimized for use in a screening application in which the patient sample is obtained by assaying components found in the peripheral blood such as epithelial cells. The result of the selected portfolio contains 31 genes as shown in Table 2.  
                                               Cancer                       Type   Accession   Name   Description   Seq. ID No.                   PR   Hs.12784   KIAA0293   KIAA0293 protein   Seq. ID No. 67       PR   NM_006562   LBX1   transcription factor similar to D. melanogaster   Seq. ID No. 33                   homeodomain protein lady bird late       PR   NM_016026   LOC51109   CGI-82 protein   Seq. ID No. 34       PR   HG2261-   None   Antigen   Seq. ID No. 99           HT2352       PR   NM_012449   STEAP   six transmembrane epithelial antigen of the prostate   Seq. ID No.35       PR   NM_001634   AMD1   S-adenosylmethionine decarboxylase 1   Seq. ID No. 36       PR   HG2261-   None   Antigen |   Seq. ID No. 100           HT2351       PR   NM_006457   LIM   LIM protein (similar to rat protein kinase C-binding   Seq. ID No. 37                   enigma)       BR   NM_005853   IRX5   iroquois homeobox protein 5   Seq. ID No. 38       BR   NM_005264   GFRA1   GDNF family receptor alpha 1   Seq. ID No. 39       BR   none   C18ORF1   chromosome 18 open reading frame 1   Seq. ID No. 98       BR   NM_000095   COMP   cartilage oligomeric matrix protein   Seq. ID No. 41                   (pseudoachondroplasia, epiphyseal dysplasia 1,                   multiple)       CO   NM_001265   CDX2   caudal type homeo box transcription factor 2   Seq. ID No. 43       CO   NM_001046   SLC12A2   solute carrier family 12 (sodium/potassium/chloride   Seq. ID No. 44                   transporters), member 2       CO   NM_001285   CLCA1   chloride channel, calcium activated, family member 1   Seq. ID No. 46       CO   NM_004063   CDH17   cadherin 17, LI cadherin (liver-intestine)   Seq. ID No. 48       OV   NM_000906   NPR1   natriuretic peptide receptor A/guanylate cyclase A   Seq. ID No. 50                   (atrionatriuretic peptide receptor A)       OV   NM_005504   BCAT1   branched chain aminotransferase 1, cytosolic   Seq. ID No. 52       OV   NM_002398   MEIS1   Meis1 (mouse) homolog   Seq. ID No. 53       OV   none   SPON1   spondin 1, (f-spondin) extracellular matrix protein   Seq. ID No. 69       OV   NM_001692   None   M25809:Human endomembrane proton pump   Seq. ID No. 54                   subunit mRNA |GenBank==M25809       OV   NM_002774   KLK6   kallikrein 6 (neurosin, zyme)   Seq. ID No. 55       LU_A   NM_000964   ASAHL   N-acylsphingosine amidohydrolase (acid   Seq. ID No. 56                   ceramidase)-like       LU_A   NM_002838   PTPRC   protein tyrosine phosphatase, receptor type, C   Seq. ID No. 58       LU_A   NM_015364   MD-2   MD-2 protein   Seq. ID No. 59       LU_A   NM_006875   PIM2   pim-2 oncogene   Seq. ID No. 60       LU_S   NM_005554   KRT6A   keratin 6A   Seq. ID No. 61       LU_S   NM_000673   ADH7   alcohol dehydrogenase 7 (class IV), mu or sigma   Seq. ID No. 62                   polypeptide       LU_S   NM_003722   TP63   tumor protein 63 kDa with strong homology to p53   Seq. ID No. 64       LU_S   none   SOX2   SRY (sex determining region Y)-box 2   Seq. ID No. 32       LU_S   NM_005688   ABCC5   ATP-binding cassette, sub-family C (CFTR/MRP),   Seq. ID No. 66                   member 5                  
 
       Example 3  
       [0063]    Prognostic Portfolios  
         [0064]    A patient sample set with known clinical outcomes was used to test the portfolio selection method of the invention. The sample set is described in van&#39;t Veer, L. J et al. Gene Expression Profiling Predicts Clinical Outcome of Breast Cancer,  Nature,  415, 530-536, (2002), incorporated herein by reference. In that study, breast tissue samples were obtained from 78 patients exhibiting sporadic breast tumors. The patients were all less than 55 years of age and presented with a tumor less than 5cm. All were lymph node negative. Thirty four of the patients presented with distant metastases in less than 5 years while 44 showed no distant metastases in the same period.  
         [0065]    Sample preparation and expression profiling are described in the reference. A prognostic marker portfolio of 70 genes was selected from consideration of about 5,000 genes differentially expressed in patients with different prognoses (metastasis v. no metastasis). The selection was made based on unsupervised clustering followed by a correlation coefficient analysis. This was done by calculating the correlation coefficient of the expression of each gene with disease outcome. Those significantly associated with disease by this analysis were then rank ordered with successive groups of five compared using the “leave-one-out” method until an “optimized” panel of 70 genes was selected.  
         [0066]    The data from the study were then processed according to the method of the invention. Sample number 54 was removed from further analysis due to a high percentage of missing values. The mean and standard deviation of the intensity measurements for each gene were calculated using the non-metastatic samples as the baseline. A discriminating value of X*(Standard Deviation+Mean) was then calculated for each baseline gene ( X was assigned a value of 3). This value was used to ensure the resulting portfolio would be stringent. A ratio of the discriminating value to the baseline value was then calculated for each metastatic sample. This ratio was then converted to a common logarithm. This data was then imported into Wagner Software which produced an efficient frontier from which a portfolio of 16 genes was selected. The baseline and experimental values were then reversed and a second portfolio of 12 markers representing genes up-regulated in the non-metastatic cases was produced. The second portfolio&#39;s value is subtracted from the first portfolios value to create a combined portfolio value from all 28 genes. This final portfolio is comprised of genes from Seq. ID No.70 -97. 17 of the genes of this portfolio were also present in the 70 gene portfolio described in the reference. The genes of the portfolio are identified below. (Seq. ID No. 70, Seq. ID No. 72, Seq. ID No. 73-77, Seq. ID No. 79, Seq. ID No. 80, Seq. ID No.85, Seq. ID No.87, Seq. ID No.91-93, Seq. ID No.95 and Seq. ID. No.97.)  
         [0067]    28 Gene list (2 Portfolios)  
         [0068]    Up in Metastatic Patients (Portfolio 1)  
                                                       Contig53226_RC   Seq. ID No. 89           NM_012214   Seq. ID No. 82           NM_020386   Seq. ID No. 86           NM_004504   Seq. ID No. 81           AA555029_RC   Seq. ID No. 70           AL080059   Seq. ID No. 74           AF055033   Seq. ID No. 73           NM_016448   Seq. ID No. 85           Contig40831_RC   Seq. ID No. 95           Contig63649_RC   Seq. ID No. 91           Contig24252_RC   Seq. ID No. 93           NM_000436   Seq. ID No. 75           NM_002019   Seq. ID No. 77           Contig55313_RC   Seq. ID No. 90           Contig25991   Seq. ID No. 97           NM_000788   Seq. ID No. 76           Up in Non-Metastatic Patients   Seq. ID No. 71           (Portfolio 2) AB033007           Contig42421_RC   Seq. ID No. 96           NM_003748   Seq. ID No. 78           NM_013262   Seq. ID No. 83           NM_003862   Seq. ID No. 79           NM_003882   Seq. ID No. 80           Contig48328_RC   Seq. ID No. 87           NM_015416   Seq. ID No. 84           AB037863   Seq. ID No. 72           Contig27312_RC   Seq. ID No. 88           Contig32125_RC   Seq. ID No. 92           Contig49670_RC   Seq. ID No. 94                      
 
         [0069]    17 Overlap  
                                                             Systematic name                                        NM_003862   Seq. ID No. 79           NM_003882   Seq. ID No. 80           Contig48328_RC   Seq. ID No. 87           AA555029_RC   Seq. ID No. 70           AL080059   Seq. ID No. 74           AF055033   Seq. ID No. 73           AF055033   Seq. ID No. 73           NM_016448   Seq. ID No. 85           AB037863   Seq. ID No. 72           Contig40831_RO   Seq. ID No. 95           Contig63649_RC   Seq. ID No. 91           Contig24252_RC   Seq. ID No. 93           NM_000436   Seq. ID No. 75           NM_002019   Seq. ID No. 77           Contig32125_RC   Seq. ID No. 92           Contig25991   Seq. ID No. 97           NM_000788   Seq. ID No. 76                      
 
         [0070]    The two portfolios were then used to determine the prognosis of the 78 original samples by comparing gene expression signatures from the microarray data according to the method for testing the classification accuracy described in the reference. In the case of the 70 gene portfolio, 81% of the samples were properly characterized according to an optimized threshold biased to include ambiguous signatures as indicative of poor prognosis (85% for an absolute threshold). This portfolio misclassified 3 patients with a poor prognosis as having a good prognosis using the optimized threshold (5 for the absolute threshold). Twelve patients with a good prognosis were misclassified as having a good prognosis when they had a bad prognosis using the optimized threshold (8 for absolute).  
         [0071]    In the case of the 28 gene portfolio, 94% of the samples were properly characterized according to an optimized threshold biased to include ambiguous signatures as indicative of poor prognosis (93% for an absolute threshold). This portfolio misclassified 3 patients with a poor prognosis as having a good prognosis using the optimized threshold (5 for the absolute threshold). Three patients with a good prognosis were misclassified as having a good prognosis when they had a bad prognosis using the optimized threshold (2 for absolute).  
         [0072]    Comparing the two profiles, it is apparent that the profiles selected according to the method of the invention are much more economical and produce results that are more accurate and reliable than those of the comparative portfolio.  
     
       
       
         1 
         
           
             100  
           
           
             1  
             1466  
             DNA  
             human  
           
            1 

agccccaagc ttaccacctg cacccggaga gctgtgtgtc accatgtggg tcccggttgt     60 

cttcctcacc ctgtccgtga cgtggattgg tgctgcaccc ctcatcctgt ctcggattgt    120 

gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg cctctcgtgg    180 

cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag ctgcccactg    240 

catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc ctgaagacac    300 

aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata tgagcctcct    360 

gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc tgctccgcct    420 

gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca cccaggagcc    480 

agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag aggagttctt    540 

gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg tgtgtgcgca    600 

agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga cagggggcaa    660 

aagcacctgc tcgggtgatt ctgggggccc acttgtctgt aatggtgtgc ttcaaggtat    720 

cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt acaccaaggt    780 

ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctgag cacccctatc    840 

aaccccctat tgtagtaaac ttggaacctt ggaaatgacc aggccaagac tcaagcctcc    900 

ccagttctac tgacctttgt ccttaggtgt gaggtccagg gttgctagga aaagaaatca    960 

gcagacacag gtgtagacca gagtgtttct taaatggtgt aattttgtcc tctctgtgtc   1020 

ctggggaata ctggccatgc ctggagacat atcactcaat ttctctgagg acacagatag   1080 

gatggggtgt ctgtgttatt tgtggggtac agagatgaaa gaggggtggg atccacactg   1140 

agagagtgga gagtgacatg tgctggacac tgtccatgaa gcactgagca gaagctggag   1200 

gcacaacgca ccagacactc acagcaagga tggagctgaa aacataaccc actctgtcct   1260 

ggaggcactg ggaagcctag agaaggctgt gagccaagga gggagggtct tcctttggca   1320 

tgggatgggg atgaagtaag gagagggact ggaccccctg gaagctgatt cactatgggg   1380 

ggaggtgtat tgaagtcctc cagacaaccc tcagatttga tgatttccta gtagaactca   1440 

cagaaataaa gagctgttat actgtg                                        1466 

 
           
             2  
             786  
             DNA  
             human  
           
            2 

atgtgggacc tggttctctc catcgccttg tctgtggggt gcactggtgc cgtgcccctc     60 

atccagtctc ggattgtggg aggctgggag tgtgagaagc attcccaacc ctggcaggtg    120 

gctgtgtaca gtcatggatg ggcacactgt gggggtgtcc tggtgcaccc ccagtgggtg    180 

ctcacagctg cccattgcct aaagaagaat agccaggtct ggctgggtcg gcacaacctg    240 

tttgagcctg aagacacagg ccagagggtc cctgtcagcc acagcttccc acacccgctc    300 

tacaatatga gccttctgaa gcatcaaagc cttagaccag atgaagactc cagccatgac    360 

ctcatgctgc tccgcctgtc agagcctgcc aagatcacag atgttgtgaa ggtcctgggc    420 

ctgcccaccc aggagccagc actggggacc acctgctacg cctcaggctg gggcagcatc    480 

gaaccagagg agttcttgcg ccccaggagt cttcagtgtg tgagcctcca tctcctgtcc    540 

aatgacatgt gtgctagagc ttactctgag aaggtgacag agttcatgtt gtgtgctggg    600 

ctctggacag gtggtaaaga cacttgtggg ggtgattctg ggggtccact tgtctgtaat    660 

ggggtgcttc aaggtatcac atcatggggc cctgagccat gtgccctgcc tgaaaagcct    720 

gctgtgtaca ccaaggtggt gcattaccgg aagtggatca aggacaccat cgcagccaac    780 

ccctga                                                               786 

 
           
             3  
             503  
             DNA  
             human  
           
            3 

gacagcggct tccttgatcc ttgccacccg cgactgaaca ccgacagcag cagcctcacc     60 

atgaagttgc tgatggtcct catgctggcg gccctctccc agcactgcta cgcaggctct    120 

ggctgcccct tattggagaa tgtgatttcc aagacaatca atccacaagt gtctaagact    180 

gaatacaaag aacttcttca agagttcata gacgacaatg ccactacaaa tgccatagat    240 

gaattgaagg aatgttttct taaccaaacg gatgaaactc tgagcaatgt tgaggtgttt    300 

atgcaattaa tatatgacag cagtctttgt gatttatttt aactttctgc aagacctttg    360 

gctcacagaa ctgcagggta tggtgagaaa ccaactacgg attgctgcaa accacacctt    420 

ctctttctta tgtcttttta ctacaaacta caagacaatt gttgaaacct gctatacatg    480 

tttattttaa taaattgatg gca                                            503 

 
           
             4  
             2560  
             DNA  
             human  
           
            4 

gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata     60 

accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc    120 

caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct    180 

tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc    240 

ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg    300 

ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc    360 

atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca    420 

ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg    480 

ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca    540 

gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt    600 

gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca    660 

gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg    720 

caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc    780 

catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa    840 

ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct    900 

gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt    960 

cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct   1020 

ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat   1080 

caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc   1140 

cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc   1200 

ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta   1260 

tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat   1320 

ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag   1380 

cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac   1440 

agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg   1500 

cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa   1560 

tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca   1620 

gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa   1680 

caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg   1740 

tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat   1800 

ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc   1860 

aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct   1920 

gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac   1980 

atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca   2040 

gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt   2100 

aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc   2160 

aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt   2220 

aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac   2280 

agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca   2340 

tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag   2400 

cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg   2460 

atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag   2520 

ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc                         2560 

 
           
             5  
             2560  
             DNA  
             human  
           
            5 

gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata     60 

accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc    120 

caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct    180 

tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc    240 

ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg    300 

ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc    360 

atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca    420 

ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg    480 

ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca    540 

gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt    600 

gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca    660 

gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg    720 

caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc    780 

catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa    840 

ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct    900 

gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt    960 

cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct   1020 

ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat   1080 

caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc   1140 

cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc   1200 

ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta   1260 

tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat   1320 

ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag   1380 

cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac   1440 

agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg   1500 

cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa   1560 

tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca   1620 

gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa   1680 

caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg   1740 

tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat   1800 

ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc   1860 

aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct   1920 

gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac   1980 

atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca   2040 

gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt   2100 

aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc   2160 

aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt   2220 

aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac   2280 

agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca   2340 

tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag   2400 

cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg   2460 

atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag   2520 

ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc                         2560 

 
           
             6  
             2439  
             DNA  
             human  
           
            6 

cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac     60 

cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc    120 

gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct    180 

gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg    240 

cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc    300 

gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg    360 

cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa    420 

cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga    480 

ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa    540 

ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt    600 

ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg    660 

cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg    720 

ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc    780 

gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct    840 

agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg    900 

cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg    960 

cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg   1020 

gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg   1080 

gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga   1140 

cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa   1200 

ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca   1260 

gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag   1320 

cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc   1380 

taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga   1440 

cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca   1500 

ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa   1560 

ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag   1620 

ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt   1680 

ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt   1740 

gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac   1800 

ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt   1860 

catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga   1920 

gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa   1980 

cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg   2040 

aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt   2100 

gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt   2160 

cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat   2220 

catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca   2280 

tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc   2340 

gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag   2400 

aagggctcag agaggacaaa ataaagtgtg tgtgcaggg                          2439 

 
           
             7  
             2439  
             DNA  
             human  
           
            7 

cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac     60 

cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc    120 

gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct    180 

gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg    240 

cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc    300 

gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg    360 

cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa    420 

cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga    480 

ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa    540 

ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt    600 

ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg    660 

cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg    720 

ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc    780 

gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct    840 

agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg    900 

cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg    960 

cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg   1020 

gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg   1080 

gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga   1140 

cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa   1200 

ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca   1260 

gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag   1320 

cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc   1380 

taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga   1440 

cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca   1500 

ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa   1560 

ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag   1620 

ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt   1680 

ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt   1740 

gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac   1800 

ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt   1860 

catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga   1920 

gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa   1980 

cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg   2040 

aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt   2100 

gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt   2160 

cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat   2220 

catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca   2280 

tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc   2340 

gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag   2400 

aagggctcag agaggacaaa ataaagtgtg tgtgcaggg                          2439 

 
           
             8  
             1699  
             DNA  
             human  
           
            8 

aggtgagcgg ttgctcgtcg tcggggcggc cggcagcggc ggctccaggg cccagcatgc     60 

gcgggggacc ccgcggccac catgtatgtg ggctatgtgc tggacaagga ttcgcccgtg    120 

taccccggcc cagccaggcc agccagcctc ggcctgggcc cggcaaacta cggccccccg    180 

gccccgcccc cggcgccccc gcagtacccc gacttctcca gctactctca cgtggagccg    240 

gcccccgcgc ccccgacggc ctggggggcg cccttccctg cgcccaagga cgactgggcc    300 

gccgcctacg gcccgggccc cgcggcccct gccgccagcc cagcttcgct ggcattcggg    360 

ccccctccag actttagccc ggtgccggcg ccccctgggc ccggcccggg cctcctggcg    420 

cagcccctcg ggggcccggg cacaccgtcc tcgcccggag cgcagaggcc gacgccctac    480 

gagtggatgc ggcgcagcgt ggcggccgga ggcggcggtg gcagcggtaa gactcggacc    540 

aaggacaagt accgcgtggt ctacaccgac caccaacgcc tggagctgga gaaggagttt    600 

cattacagcc gttacatcac aatccggcgg aaatcagagc tggctgccaa tctggggctc    660 

actgaacggc aggtgaagat ctggttccaa aaccggcggg caaaggagcg caaagtgaac    720 

aagaagaaac agcagcagca acagccccca cagccgccga tggcccacga catcacggcc    780 

accccagccg ggccatccct ggggggcctg tgtcccagca acaccagcct cctggccacc    840 

tcctctccaa tgcctgtgaa agaggagttt ctgccatagc cccatgccca gcctgtgcgc    900 

cgggggacct ggggactcgg gtgctgggag tgtggctcct gtgggcccag gaggtctggt    960 

ccgagtctca gccctgacct tctgggacat ggtggacagt cacctatcca ccctctgcat   1020 

ccccttggcc cattgtgtgc agtaagcctg ttggataaag accttccagc tcctgtgttc   1080 

tagacctctg ggggataagg gagtccaggg tggatgatct caatctcccg tgggcatctc   1140 

aagccccaaa tggttggggg aggggcctag acaaggctcc aggccccacc tcctcctcca   1200 

tacgttcaga ggtgcagctg gaggcctgtg tggggaccac actgatcctg gagaaaaggg   1260 

atggagctga aaaagatgga atgcttgcag agcatgacct gaggagggag gaacgtggtc   1320 

aactcacacc tgcctcttct gcagcctcac ctctacctgc ccccatcata agggcactga   1380 

gcccttccca ggctggatac taagcacaaa gcccatagca ctgggctctg atggctgctc   1440 

cactgggtta cagaatcaca gccctcatga tcattctcag tgagggctct ggattgagag   1500 

ggaggccctg ggaggagaga agggggcaga gtcttcccta ccaggtttct acacccccgc   1560 

caggctgccc atcagggccc agggagcccc cagaggactt tattcggacc aagcagagct   1620 

cacagctgga caggtgttgt atatagagtg gaatctcttg gatgcagctt caagaataaa   1680 

tttttcttct cttttcaaa                                                1699 

 
           
             9  
             4098  
             DNA  
             human  
           
            9 

ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcgggga gaaagactct     60 

ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggc gtgctgccgg    120 

agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggag ccgcggccca    180 

cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccg tcagccgctg    240 

cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtg ccggaggatg    300 

ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcg gcggccgggg    360 

acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccag gtggacctgg    420 

tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcg gcagcggcgg    480 

cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagcc agcggcgaga    540 

gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaac ttcgtggacc    600 

cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtc ggagtcgacg    660 

ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggc agcagcctgc    720 

actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgat acccacacca    780 

acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgccc aggatcgatc    840 

actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagc ctggcggagc    900 

tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggg gaagaaagta    960 

ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtc gtgaagtttg   1020 

gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtg atgcttttca   1080 

ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtcctt gtaataatga   1140 

tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagca actaatggat   1200 

ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggcca gaatttggtg   1260 

gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatg tatgtggttg   1320 

gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatg atagatgaaa   1380 

tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggt atctcagtag   1440 

ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatccta cttcttgcta   1500 

ttggtgattt cgtcatagga acatttatcc cactggagag caagaagcca aaagggtttt   1560 

ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcga gaggaagaga   1620 

ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctg gctggagcaa   1680 

atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaaca ctcctagcca   1740 

ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc   1800 

gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaac tgtacttctg   1860 

cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgt tcctatggcc   1920 

taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccacta atttctgcag   1980 

gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgct cccaaaatat   2040 

ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgct aaaggttatg   2100 

ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgca cttggattca   2160 

tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttc cttgcatcat   2220 

atgcattgat caatttttca gtattccatg catcacttgc aaaatctcca ggatggcgtc   2280 

ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctt tgttgcatag   2340 

taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtc cttgggctgt   2400 

atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctaca caagccctga   2460 

cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagac cacgtgaaaa   2520 

actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtcca gctttacttc   2580 

atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccat gtacatatgg   2640 

gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatat cagcgatggc   2700 

ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgac ttgagagaag   2760 

gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaac acacttgtcc   2820 

ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatg tatataaact   2880 

tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgccta aaagaaggtc   2940 

tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagag aaatctcctg   3000 

gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgattta gatacttcca   3060 

aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggc aagactgcaa   3120 

ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaat gtagctgacc   3180 

aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaat actattgatg   3240 

tctggtggct ttttgatgat ggaggtttga ccttattgat accttacctt ctgacgacca   3300 

agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagata aacagaatag   3360 

accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagac ttttctgata   3420 

tcatggttct aggagatatc aataccaaac caaagaaaga aaatattata gcttttgagg   3480 

aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatatt gcagataaaa   3540 

tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttat aagaccaaga   3600 

cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcaca gctaatatta   3660 

ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctc tacatggcat   3720 

ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtggg aatcatcaga   3780 

gtgtccttac cttctattca taaatgttct atacagtgga cagccctcca gaatggtact   3840 

tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcac aatggcgaat   3900 

ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagct tgctccattg   3960 

ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatctta atggtgattc   4020 

ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaa tagcaataaa   4080 

agcgtgttaa ctttttgg                                                 4098 

 
           
             10  
             4098  
             DNA  
             human  
           
            10 

ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcgggga gaaagactct     60 

ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggc gtgctgccgg    120 

agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggag ccgcggccca    180 

cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccg tcagccgctg    240 

cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtg ccggaggatg    300 

ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcg gcggccgggg    360 

acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccag gtggacctgg    420 

tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcg gcagcggcgg    480 

cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagcc agcggcgaga    540 

gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaac ttcgtggacc    600 

cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtc ggagtcgacg    660 

ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggc agcagcctgc    720 

actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgat acccacacca    780 

acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgccc aggatcgatc    840 

actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagc ctggcggagc    900 

tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggg gaagaaagta    960 

ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtc gtgaagtttg   1020 

gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtg atgcttttca   1080 

ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtcctt gtaataatga   1140 

tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagca actaatggat   1200 

ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggcca gaatttggtg   1260 

gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatg tatgtggttg   1320 

gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatg atagatgaaa   1380 

tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggt atctcagtag   1440 

ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatccta cttcttgcta   1500 

ttggtgattt cgtcatagga acatttatcc cactggagag caagaagcca aaagggtttt   1560 

ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcga gaggaagaga   1620 

ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctg gctggagcaa   1680 

atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaaca ctcctagcca   1740 

ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc   1800 

gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaac tgtacttctg   1860 

cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgt tcctatggcc   1920 

taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccacta atttctgcag   1980 

gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgct cccaaaatat   2040 

ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgct aaaggttatg   2100 

ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgca cttggattca   2160 

tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttc cttgcatcat   2220 

atgcattgat caatttttca gtattccatg catcacttgc aaaatctcca ggatggcgtc   2280 

ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctt tgttgcatag   2340 

taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtc cttgggctgt   2400 

atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctaca caagccctga   2460 

cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagac cacgtgaaaa   2520 

actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtcca gctttacttc   2580 

atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccat gtacatatgg   2640 

gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatat cagcgatggc   2700 

ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgac ttgagagaag   2760 

gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaac acacttgtcc   2820 

ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatg tatataaact   2880 

tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgccta aaagaaggtc   2940 

tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagag aaatctcctg   3000 

gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgattta gatacttcca   3060 

aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggc aagactgcaa   3120 

ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaat gtagctgacc   3180 

aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaat actattgatg   3240 

tctggtggct ttttgatgat ggaggtttga ccttattgat accttacctt ctgacgacca   3300 

agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagata aacagaatag   3360 

accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagac ttttctgata   3420 

tcatggttct aggagatatc aataccaaac caaagaaaga aaatattata gcttttgagg   3480 

aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatatt gcagataaaa   3540 

tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttat aagaccaaga   3600 

cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcaca gctaatatta   3660 

ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctc tacatggcat   3720 

ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtggg aatcatcaga   3780 

gtgtccttac cttctattca taaatgttct atacagtgga cagccctcca gaatggtact   3840 

tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcac aatggcgaat   3900 

ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagct tgctccattg   3960 

ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatctta atggtgattc   4020 

ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaa tagcaataaa   4080 

agcgtgttaa ctttttgg                                                 4098 

 
           
             11  
             3311  
             DNA  
             human  
           
            11 

tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg     60 

gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa    120 

tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag    180 

agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata    240 

agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac    300 

cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca    360 

tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca    420 

ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg    480 

ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat    540 

ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa    600 

acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat    660 

gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc    720 

aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag    780 

ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg    840 

ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa    900 

gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc    960 

agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt   1020 

gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt   1080 

gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa   1140 

aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag   1200 

aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga   1260 

caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc   1320 

aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg   1380 

gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac   1440 

agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg   1500 

tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat   1560 

ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac   1620 

gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa   1680 

gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt   1740 

cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct   1800 

cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat   1860 

ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca   1920 

acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta   1980 

gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact   2040 

tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg   2100 

tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa   2160 

ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg   2220 

gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg   2280 

gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca   2340 

acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca   2400 

gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag   2460 

aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac   2520 

aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca   2580 

aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt   2640 

cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga   2700 

acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc   2760 

aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa   2820 

gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct   2880 

attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct   2940 

ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct   3000 

tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg   3060 

aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata   3120 

aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc   3180 

tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg   3240 

ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac   3300 

aactgggtaa a                                                        3311 

 
           
             12  
             3311  
             DNA  
             human  
           
            12 

tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg     60 

gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa    120 

tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag    180 

agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata    240 

agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac    300 

cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca    360 

tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca    420 

ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg    480 

ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat    540 

ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa    600 

acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat    660 

gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc    720 

aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag    780 

ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg    840 

ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa    900 

gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc    960 

agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt   1020 

gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt   1080 

gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa   1140 

aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag   1200 

aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga   1260 

caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc   1320 

aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg   1380 

gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac   1440 

agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg   1500 

tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat   1560 

ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac   1620 

gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa   1680 

gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt   1740 

cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct   1800 

cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat   1860 

ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca   1920 

acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta   1980 

gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact   2040 

tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg   2100 

tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa   2160 

ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg   2220 

gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg   2280 

gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca   2340 

acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca   2400 

gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag   2460 

aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac   2520 

aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca   2580 

aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt   2640 

cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga   2700 

acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc   2760 

aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa   2820 

gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct   2880 

attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct   2940 

ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct   3000 

tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg   3060 

aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata   3120 

aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc   3180 

tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg   3240 

ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac   3300 

aactgggtaa a                                                        3311 

 
           
             13  
             2609  
             DNA  
             human  
             
               misc_feature  
               (2025)..(2025)  
               any kind of base  
             
           
            13 

gctgatagca cagttctgtc cagagaagga aggcggaata aacttattca ttcccaggaa     60 

ctcttggggt aggtgtgtgt ttttcacatc ttaaaggctc acagaccctg cgctggacaa    120 

atgttccatt cctgaaggac ctctccagaa tccggattgc tgaatcttcc ctgttgccta    180 

gaagggctcc aaaccacctc ttgacaatgg gaaactgggt ggttaaccac tggttttcag    240 

ttttgtttct ggttgtttgg ttagggctga atgttttcct gtttgtggat gccttcctga    300 

aatatgagaa ggccgacaaa tactactaca caagaaaaat ccttgggtca acattggcct    360 

gtgcccgagc gtctgctctc tgcttgaatt ttaacagcac gctgatcctg cttcctgtgt    420 

gtcgcaatct gctgtccttc ctgaggggca cctgctcatt ttgcagccgc acactgagaa    480 

agcaattgga tcacaacctc accttccaca agctggtggc ctatatgatc tgcctacata    540 

cagctattca catcattgca cacctgttta actttgactg ctatagcaga agccgacagg    600 

ccacagatgg ctcccttgcc tccattctct ccagcctatc tcatgatgag aaaaaggggg    660 

gttcttggct aaatcccatc cagtcccgaa acacgacagt ggagtatgtg acattcacca    720 

gcgttgctgg tctcactgga gtgatcatga caatagcctt gattctcatg gtaacttcag    780 

ctactgagtt catccggagg agttattttg aagtcttctg gtatactcac caccttttta    840 

tcttctatat ccttggctta gggattcacg gcattggtgg aattgtccgg ggtcaaacag    900 

aggagagcat gaatgagagt catcctcgca agtgtgcaga gtcttttgag atgtgggatg    960 

atcgtgactc ccactgtagg cgccctaagt ttgaagggca tccccctgag tcttggaagt   1020 

ggatccttgc accggtcatt ctttatatct gtgaaaggat cctccggttt taccgctccc   1080 

agcagaaggt tgtgattacc aaggttgtta tgcacccatc caaagttttg gaattgcaga   1140 

tgaacaagcg tggcttcagc atggaagtgg ggcagtatat ctttgttaat tgcccctcaa   1200 

tctctctcct ggaatggcat ccttttactt tgacctctgc tccagaggaa gatttcttct   1260 

ccattcatat ccgagcagca ggggactgga cagaaaatct cataagggct ttcgaacaac   1320 

aatattcacc aattcccagg attgaagtgg atggtccctt tggcacagcc agtgaggatg   1380 

ttttccagta tgaagtggct gtgctggttg gagcaggaat tggggtcacc ccctttgctt   1440 

ctatcttgaa atccatctgg tacaaattcc agtgtgcaga ccacaacctc aaaacaaaaa   1500 

agatctattt ctactggatc tgcagggaga caggtgcctt ttcctggttc aacaacctgt   1560 

tgacttccct ggaacaggag atggaggaat taggcaaagt gggttttcta aactaccgtc   1620 

tcttcctcac cggatgggac agcaatattg ttggtcatgc agcattaaac tttgacaagg   1680 

ccactgacat cgtgacaggt ctgaaacaga aaacctcctt tgggagacca atgtgggaca   1740 

atgagttttc tacaatagct acctcccacc ccaagtctgt agtgggagtt ttcttatgtg   1800 

gccctcggac tttggcaaag agcctgcgca aatgctgtca ccgatattcc agtctggatc   1860 

ctagaaaggt tcaattctac ttcaacaaag aaaatttttg agttatagga ataaggacgg   1920 

taatctgcat tttgtctctt tgtatcttca gtaattgagt tataggaata aggacggtaa   1980 

tctgcatttt gtctctttgt atcttcagta atttacttgg tctcntcagg tttgancagt   2040 

cactttagga taagaatgtg cctctcaagc cttgactccc tggtattctt tttttgattg   2100 

cattcaactt cgttacttga gcttcagcaa cttaagaact tctgaagttc ttaaagttct   2160 

gaanttctta aagcccatgg atcctttctc agaaaaataa ctgtaaatct ttctggacag   2220 

ccatgactgt agcaaggctt gatagcagaa gtttggtggt tcanaattat acaactaatc   2280 

ccaggtgatt ttatcaattc cagtgttacc atctcctgag ttttggtttg taatcttttg   2340 

tccctcccac ccccacagaa gattttaagt agggtgactt tttaaataaa aatttattga   2400 

ataattaatg ataaaacata ataataaaca taaataataa acaaaattac cgagaacccc   2460 

atccccatat aacaccaaca gtgtacatgt ttactgtcac ttttgatatg gtttatccag   2520 

tgtgaacagc aatttattat ttttgctcat caaaaaataa aggatttttt ttcacttgaa   2580 

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     2609 

 
           
             14  
             15720  
             DNA  
             human  
           
            14 

caacccacac cgcccctgcc agccaccatg gggctgccac tagcccgcct ggcggctgtg     60 

tgcctggccc tgtctttggc agggggctcg gagctccaga cagagggcag aacccgatac    120 

cacggccgca acgtctgcag cacctggggc aacttccact acaagacctt cgacggggac    180 

gtcttccgct tccccggcct ctgcgactac aacttcgcct ccgactgccg aggctcctac    240 

aaggaatttg ctgtgcacct gaagcggggt ccgggccagg ctgaggcccc cgccggggtg    300 

gagtccatcc tgctgaccat caaggatgac accatctacc tcacccgcca cctggctgtg    360 

cttaacgggg ccgtggtcag caccccgcac tacagccccg ggctgctcat tgagaagagc    420 

gatgcctaca ccaaagtcta ctcccgcgcc ggcctcaccc tcatgtggaa ccgggaggat    480 

gcactcatgc tggagctgga cactaagttc cggaaccaca cctgtggcct ctgcggggac    540 

tacaacggcc tgcagagcta ttcagaattc ctctctgacg gcgtgctctt cagtcccctg    600 

gagtttggga acatgcagaa gatcaaccag cccgatgtgg tgtgtgagga tcccgaggag    660 

gaggtggccc ccgcatcctg ctccgagcac cgcgccgagt gtgagaggct gctgaccgcc    720 

gaggccttcg cggactgtca ggacctggtg ccgctggagc cgtatctgcg cgcctgccag    780 

caggaccgct gccggtgccc gggcggtgac acctgcgtct gcagcaccgt ggccgagttc    840 

tcccgccagt gctcccacgc cggcggccgg cccgggaact ggaggaccgc cacgctctgc    900 

cccaagacct gccccgggaa cctggtgtac ctggagagcg gctcgccctg catggacacc    960 

tgctcacacc tggaggtgag cagcctgtgc gaggagcacc gcatggacgg ctgtttctgc   1020 

ccagaaggca ccgtatatga cgacatcggg gacagtggct gcgttcctgt gagccagtgc   1080 

cactgcaggc tgcacggaca cctgtacaca ccgggccagg agatcaccaa tgactgcgag   1140 

cagtgtgtct gtaacgctgg ccgctgggtg tgcaaagacc tgccctgccc cggcacctgt   1200 

gccctggaag gcggctccca catcaccacc ttcgatggga agacgtacac cttccacggg   1260 

gactgctact atgtcctggc caagggtgac cacaacgatt cctacgctct cctgggcgag   1320 

ctggccccct gtggctccac agacaagcag acctgcctga agacggtggt gctgctggct   1380 

gacaagaaga agaatgcggt ggtcttcaag tccgatggca gtgtactgct caaccagctg   1440 

caggtgaacc tgccccacgt gaccgcgagc ttctctgtct tccgcccgtc ttcctaccac   1500 

atcatggtga gcatggccat tggcgtccgg ctgcaggtgc agctggcccc agtcatgcaa   1560 

ctctttgtga cactggacca ggcctcccag gggcaggtgc agggcctctg cgggaacttc   1620 

aacggcctgg aaggtgacga cttcaagacg gccagcgggc tggtggaggc cacgggggcc   1680 

ggctttgcca acacctggaa ggcacagtca acctgccatg acaagctgga ctggttggac   1740 

gatccctgct ccctgaacat cgagagcgcc aactacgccg agcactggtg ctccctcctg   1800 

aagaagacag agaccccctt tggcaggtgc cactcggctg tggaccctgc tgagtattac   1860 

aagaggtgca aatatgacac gtgtaactgt cagaacaatg aggactgcct gtgcgccgcc   1920 

ctgtcctcct acgcgcgcgc ctgcaccgcc aagggcgtca tgctgtgggg ctggcgggag   1980 

catgtctgca acaaggatgt gggctcctgc cccaactcgc aggtcttcct gtacaacctg   2040 

accacctgcc agcagacctg ccgctccctc tccgaggccg acagccactg tctcgagggc   2100 

tttgcgcctg tggacggctg cggctgccct gaccacacct tcctggacga gaagggccgc   2160 

tgcgtacccc tggccaagtg ctcctgttac caccgcggtc tctacctgga ggcgggggat   2220 

gtggtcgtca ggcaggaaga acgatgtgtg tgccgggatg ggcggctgca ctgtaggcag   2280 

atccggctga tcggccagag ctgcacggcc ccaaagatcc acatggactg cagcaacctg   2340 

actgcactgg ccacctcgaa gccccgagcc ctcagctgcc agacgctggc cgccggctat   2400 

taccacacag agtgtgtcag tggctgtgtg tgccccgacg ggctgatgga tgacggccgg   2460 

ggtggctgcg tggtggagaa ggaatgccct tgcgtccata acaacgacct gtattcttcc   2520 

ggcgccaaga tcaaggtgga ctgcaatacc tgcacctgca agagaggacg ctgggtgtgc   2580 

acccaggctg tgtgccatgg cacctgctcc atttacggga gtggccacta catcaccttt   2640 

gatgggaagt actacgactt tgacggacac tgctcctacg tggctgttca ggactactgc   2700 

ggccagaact cctcactggg ctcattcagc atcatcaccg agaacgtccc ctgtggcact   2760 

acgggcgtca cctgctccaa ggccatcaag atcttcatgg ggaggacgga gctgaagttg   2820 

gaagacaagc accgtgtggt gatccagcgt gatgagggtc accacgtggc ctacaccacg   2880 

cgggaggtgg gccagtacct ggtggtggag tccagcacgg gcatcatcgt catctgggac   2940 

aagaggacca ccgtgttcat caagctggct ccctcctaca agggcaccgt gtgtggcctg   3000 

tgtgggaact ttgaccaccg ctccaacaac gacttcacca cgcgggacca catggtggtg   3060 

agcagcgagc tggacttcgg gaacagctgg aaggaggccc ccacctgccc agatgtgagc   3120 

accaaccccg agccctgcag cctgaacccg caccgccgct cctgggccga gaagcagtgc   3180 

agcatcctca aaagcagcgt gttcagcatc tgccacagca aggtggaccc caagcccttc   3240 

tacgaggcct gtgtgcacga ctcgtgctcc tgtgacacgg gtggggactg tgagtgcttc   3300 

tgctctgccg tggcctccta cgcccaggag tgtaccaaag agggggcctg cgtgttctgg   3360 

aggacgccgg acctgtgccc catattctgc gactactaca accctccgca tgagtgtgag   3420 

tggcactatg agccatgtgg gaaccggagc ttcgagacct gcaggaccat caacggcatc   3480 

cactccaaca tctccgtgtc ctacctggag ggctgctacc cccggtgccc caaggacagg   3540 

cccatctatg aggaggatct gaagaagtgt gtcactgcag acaagtgtgg ctgctatgtc   3600 

gaggacaccc actacccacc tggagcatcg gttcccaccg aggagacctg caagtcctgc   3660 

gtgtgtacca actcctccca agtcgtctgc aggccggagg aaggaaagat tcttaaccag   3720 

acccaggatg gcgccttctg ctactgggag atctgtggcc ccaacgggac ggtggagaag   3780 

cacttcaaca tctgttccat tacgacacgc ccgtccaccc tgaccacctt caccaccatc   3840 

accctcccca ccacccccac ctccttcacc actaccacca ccaccaccac cccgacctcc   3900 

agcacagttt tatcaacaac tccgaagctg tgctgcctct ggtctgactg gatcaatgag   3960 

gaccacccca gcagtggcag cgacgacggt gaccgagaac catttgatgg ggtctgcggg   4020 

gcccctgagg acatcgagtg caggtcggtc aaggatcccc acctcagctt ggagcagcat   4080 

ggccagaagg tgcagtgtga tgtctctgtt gggttcattt gcaagaatga agaccagttt   4140 

ggaaatggac catttggact gtgttacgac tacaagatac gtgtcaattg ttgctggccc   4200 

atggataagt gtatcaccac tcccagccct ccaactacca ctcccagccc tccaccaacc   4260 

acgacgacca cccttccacc aaccaccacc cccagccctc caaccaccac cacaaccacc   4320 

cctccaccaa ccaccacccc cagccctcca ataaccacca cgaccacccc tctaccaacc   4380 

accactccca gccctccaat aagcaccaca accacccctc caccaaccac cactcccagc   4440 

cctccaacca ccactcccag ccctccaacc accactccca gccctccaac aaccaccaca   4500 

accacccctc caccaaccac cactcccagc cctccaatga ctacgcccat cactccacca   4560 

gccagcacta ccacccttcc accaaccacc actcccagcc ctccaacaac caccacaacc   4620 

acccctccac caaccaccac tcccagtcct ccaacgacta cgcccatcac tccaccaacc   4680 

agcactacta cccttccacc aaccaccact cccagccctc caccaaccac cacaaccacc   4740 

cctccaccaa ccaccactcc cagccctcca acaaccacca ctcccagtcc tccaacaatc   4800 

accacaacca cccctccacc aaccaccact cccagccctc caacaacgac cacaaccacc   4860 

cctccaccaa ccaccactcc cagccctcca acgactacac ccatcactcc accaaccagc   4920 

actaccaccc ttccaccaac caccactccc agccctccac caaccaccac aaccacccct   4980 

ccaccaacca ccactcccag ccctccaaca accaccactc ccagccctcc aataaccacc   5040 

acaaccaccc ctccaccaac caccactccc agctctccaa taaccaccac tcccagccct   5100 

ccaacaacca ccatgaccac cccttcacca accaccaccc ccagctctcc aataaccacc   5160 

acaaccaccc cttcctcaac taccactccc agccctccac caaccaccat gaccacccct   5220 

tcaccaacca ccactcccag ccctccaaca accaccatga ccacccttcc accaaccacc   5280 

acttccagcc ctctaacaac tactcctcta cctccatcaa taactcctcc tacattttca   5340 

ccattctcaa cgacaacccc tactacccca tgcgtgcctc tctgcaattg gactggctgg   5400 

ctggattctg gaaaacccaa ctttcacaaa ccaggtggag acacagaatt gattggagac   5460 

gtctgtggac caggctgggc agctaacatc tcttgcagag ccaccatgta tcctgatgtt   5520 

cccattggac agcttggaca aacagtggtg tgtgatgtct ctgtggggct gatatgcaaa   5580 

aatgaagacc aaaagccagg tggggtcatc cctatggcct tctgcctcaa ctacgagatc   5640 

aacgttcagt gctgtgagtg tgtcacccaa cccaccacca tgacaaccac caccacagag   5700 

aacccaactc cgccaaccac gacacccatc accaccacca ctacggtgac cccaacccca   5760 

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc   5820 

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact   5880 

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc   5940 

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca   6000 

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca   6060 

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca   6120 

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc   6180 

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc   6240 

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg   6300 

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc   6360 

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc   6420 

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg   6480 

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc   6540 

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc   6600 

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca   6660 

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca   6720 

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg   6780 

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc   6840 

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc   6900 

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc   6960 

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag   7020 

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc   7080 

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca   7140 

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc   7200 

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact   7260 

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc   7320 

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca   7380 

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca   7440 

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca   7500 

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc   7560 

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc   7620 

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg   7680 

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc   7740 

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc   7800 

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg   7860 

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc   7920 

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc   7980 

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca   8040 

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca   8100 

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg   8160 

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc   8220 

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc   8280 

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc   8340 

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag   8400 

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc   8460 

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca   8520 

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc   8580 

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact   8640 

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc   8700 

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca   8760 

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca   8820 

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca   8880 

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc   8940 

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc   9000 

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg   9060 

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc   9120 

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc   9180 

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg   9240 

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc   9300 

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc   9360 

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca   9420 

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca   9480 

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg   9540 

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc   9600 

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc   9660 

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc   9720 

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag   9780 

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc   9840 

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca   9900 

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc   9960 

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact  10020 

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc  10080 

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca  10140 

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca  10200 

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca  10260 

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc  10320 

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc  10380 

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg  10440 

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc  10500 

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc  10560 

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg  10620 

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc  10680 

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc  10740 

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca  10800 

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca  10860 

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg  10920 

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc  10980 

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc  11040 

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc  11100 

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag  11160 

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc  11220 

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca  11280 

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc  11340 

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact  11400 

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc  11460 

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca  11520 

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca  11580 

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca  11640 

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc  11700 

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc  11760 

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg  11820 

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc  11880 

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc  11940 

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg  12000 

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc  12060 

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc  12120 

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca  12180 

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca  12240 

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg  12300 

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc  12360 

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc  12420 

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc  12480 

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag  12540 

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc  12600 

ggcacacaga ccgggccccc cacccacaca agcacagcac cgattgctga gttgaccaca  12660 

tccaatcctc cgcctgagtc ctcaacccct cagacctctc ggtccacctc ttcccctctc  12720 

acggagtcaa ccacccttct gagtacccta ccacctgcca ttgagatgac cagcacggcc  12780 

ccaccctcca cacccacggc acccacgacc acgagcggag gccacacact gtctccaccg  12840 

cccagcacca ccacgtcccc tccaggcacc cccactcgcg gtaccacgac cgggtcatct  12900 

tcagccccca cccccagcac tgtgcagacg accaccacca gtgcctggac cccaacgccg  12960 

accccactct ccacacccag catcatcagg accacaggcc tgaggcccta cccttcctct  13020 

gtgcttatct gctgtgtcct gaacgacacc tactacgcac caggtgagga ggtgtacaac  13080 

ggcacatacg gagacacctg ttatttcgtc aactgctcac tgagctgtac gttggagttc  13140 

tataactggt cctgcccatc cacgccctcc ccaacaccca cgccctccaa gtcgacgccc  13200 

acgccttcca agccatcgtc cacgccctcc aagccgacgc ccggcaccaa gccccccgag  13260 

tgcccagact ttgatcctcc cagacaggag aacgagactt ggtggctgtg cgactgcttc  13320 

atggccacgt gcaagtacaa caacacggtg gagatcgtga aggtggagtg tgagccgccg  13380 

cccatgccca cctgctccaa cggcctccaa cccgtgcgcg tcgaggaccc cgacggctgc  13440 

tgctggcact gggagtgcga ctgctactgc acgggctggg gcgacccgca ctatgtcacc  13500 

ttcgacggac tctactacag ctaccagggc aactgcacct acgtgctggt ggaggagatc  13560 

agcccctccg tggacaactt cggagtttac atcgacaact accactgcga tcccaacgac  13620 

aaggtgtcct gtccccgcac cctcatcgtg cgccacgaga cccaggaggt gctgatcaag  13680 

accgtgcata tgatgcccat gcaggtgcag gtgcaggtga acaggcaggc ggtggcactg  13740 

ccctacaaga agtacgggct ggaggtgtac cagtctggca tcaactacgt ggtggacatc  13800 

cccgagctgg gtgtcctcgt ctcctacaat ggcctgtcct tctccgtcag gctgccctac  13860 

caccggtttg gcaacaacac caagggccag tgtggcacct gcaccaacac cacctccgac  13920 

gactgcattc tgcccagcgg ggagatcgtc tccaactgtg aggctgcggc tgaccagtgg  13980 

ctggtgaacg acccctccaa gccacactgc ccccacagca gctccacgac caagcgcccg  14040 

gccgtcactg tgcccggggg cggtaaaacg accccacaca aggactgcac cccatctccc  14100 

ctctgccagc tcatcaagga cagcctgttt gcccagtgcc acgcactggt gcccccgcag  14160 

cactactacg atgcctgcgt gttcgacagc tgcttcatgc cgggctcgag cctggagtgc  14220 

gccagtctgc aggcctacgc agccctctgt gcccagcaga acatctgcct cgactggcgg  14280 

aaccacacgc atggggcctg cttggtggag tgcccatctc acagggagta ccaggcctgt  14340 

ggccctgcag aagagcccac gtgcaaatcc agctcctccc agcagaacaa cacagtcctg  14400 

gtggaaggct gcttctgtcc tgagggcacc atgaactacg ctcctggctt tgatgtctgc  14460 

gtgaagacct gcggctgtgt gggacctgac aatgtgccca gagagtttgg ggagcacttc  14520 

gagttcgact gcaagaactg tgtctgcctg gagggtggaa gtggcatcat ctgccaaccc  14580 

aagaggtgca gccagaagcc cgttacccac tgcgtggaag acggcaccta cctcgccacg  14640 

gaggtcaacc ctgccgacac ctgctgcaac attaccgtct gcaagtgcaa caccagcctg  14700 

tgcaaagaga agccctccgt gtgcccgctg ggattcgaag tgaagagcaa gatggtgcct  14760 

ggaaggtgct gtcccttcta ctggtgtgag tccaaggggg tgtgtgttca cgggaatgct  14820 

gagtaccagc ccggttctcc agtttattcc tccaagtgcc aggactgcgt gtgcacggac  14880 

aaggtggaca acaacaccct gctcaacgtc atcgcctgca cccacgtgcc ctgcaacacc  14940 

tcctgcagcc ctggcttcga actcatggag gcccccgggg agtgctgtaa gaagtgtgaa  15000 

cagacgcact gtatcatcaa acggcccgac aaccagcacg tcatcctgaa gcccggggac  15060 

ttcaagagcg acccgaagaa caactgcaca ttcttcagct gcgtgaagat ccacaaccag  15120 

ctcatctcgt ccgtctccaa catcacctgc cccaactttg atgccagcat ttgcatcccg  15180 

ggctccatca cattcatgcc caatggatgc tgcaagacct gcacccctcg caatgagacc  15240 

agggtgccct gctccaccgt ccccgtcacc acggaggttt cgtacgccgg ctgcaccaag  15300 

accgtcctca tgaatcattg ctccgggtcc tgcgggacat ttgtcatgta ctcggccaag  15360 

gcccaggccc tggaccacag ctgctcctgc tgcaaagagg agaaaaccag ccagcgtgag  15420 

gtggtcctga gctgccccaa tggcggctcg ctgacacaca cctacaccca catcgagagc  15480 

tgccagtgcc aggacaccgt ctgcgggctc cccaccggca cctcccgccg ggcccggcgc  15540 

tcccctaggc atctggggag cgggtgagcg gggtgggcac agcccccttc actgccctcg  15600 

acagctttac ctcccccgga ccctctgagc ctcctaagct cggcttcctc tcttcagata  15660 

tttattgtct gagtctttgt tcagtccttg ctttccaata ataaactcag ggggacatgc  15720 

 
           
             15  
             3697  
             DNA  
             human  
           
            15 

agggagtgtt cccgggggag atactccagt cgtagcaaga gtctcgacca ctgaatggaa     60 

gaaaaggact tttaaccacc attttgtgac ttacagaaag gaatttgaat aaagaaaact    120 

atgatacttc aggcccatct tcactccctg tgtcttctta tgctttattt ggcaactgga    180 

tatggccaag aggggaagtt tagtggaccc ctgaaaccca tgacattttc tatttatgaa    240 

ggccaagaac cgagtcaaat tatattccag tttaaggcca atcctcctgc tgtgactttt    300 

gaactaactg gggagacaga caacatattt gtgatagaac gggagggact tctgtattac    360 

aacagagcct tggacaggga aacaagatct actcacaatc tccaggttgc agccctggac    420 

gctaatggaa ttatagtgga gggtccagtc cctatcacca tagaagtgaa ggacatcaac    480 

gacaatcgac ccacgtttct ccagtcaaag tacgaaggct cagtaaggca gaactctcgc    540 

ccaggaaagc ccttcttgta tgtcaatgcc acagacctgg atgatccggc cactcccaat    600 

ggccagcttt attaccagat tgtcatccag cttcccatga tcaacaatgt catgtacttt    660 

cagatcaaca acaaaacggg agccatctct cttacccgag agggatctca ggaattgaat    720 

cctgctaaga atccttccta taatctggtg atctcagtga aggacatggg aggccagagt    780 

gagaattcct tcagtgatac cacatctgtg gatatcatag tgacagagaa tatttggaaa    840 

gcaccaaaac ctgtggagat ggtggaaaac tcaactgatc ctcaccccat caaaatcact    900 

caggtgcggt ggaatgatcc cggtgcacaa tattccttag ttgacaaaga gaagctgcca    960 

agattcccat tttcaattga ccaggaagga gatatttacg tgactcagcc cttggaccga   1020 

gaagaaaagg atgcatatgt tttttatgca gttgcaaagg atgagtacgg aaaaccactt   1080 

tcatatccgc tggaaattca tgtaaaagtt aaagatatta atgataatcc acctacatgt   1140 

ccgtcaccag taaccgtatt tgaggtccag gagaatgaac gactgggtaa cagtatcggg   1200 

acccttactg cacatgacag ggatgaagaa aatactgcca acagttttct aaactacagg   1260 

attgtggagc aaactcccaa acttcccatg gatggactct tcctaatcca aacctatgct   1320 

ggaatgttac agttagctaa acagtccttg aagaagcaag atactcctca gtacaactta   1380 

acgatagagg tgtctgacaa agatttcaag accctttgtt ttgtgcaaat caacgttatt   1440 

gatatcaatg atcagatccc catctttgaa aaatcagatt atggaaacct gactcttgct   1500 

gaagacacaa acattgggtc caccatctta accatccagg ccactgatgc tgatgagcca   1560 

tttactggga gttctaaaat tctgtatcat atcataaagg gagacagtga gggacgcctg   1620 

ggggttgaca cagatcccca taccaacacc ggatatgtca taattaaaaa gcctcttgat   1680 

tttgaaacag cagctgtttc caacattgtg ttcaaagcag aaaatcctga gcctctagtg   1740 

tttggtgtga agtacaatgc aagttctttt gccaagttca cgcttattgt gacagatgtg   1800 

aatgaagcac ctcaattttc ccaacacgta ttccaagcga aagtcagtga ggatgtagct   1860 

ataggcacta aagtgggcaa tgtgactgcc aaggatccag aaggtctgga cataagctat   1920 

tcactgaggg gagacacaag aggttggctt aaaattgacc acgtgactgg tgagatcttt   1980 

agtgtggctc cattggacag agaagccgga agtccatatc gggtacaagt ggtggccaca   2040 

gaagtagggg ggtcttcctt gagctctgtg tcagagttcc acctgatcct tatggatgtg   2100 

aatgacaacc ctcccaggct agccaaggac tacacgggct tgttcttctg ccatcccctc   2160 

agtgcacctg gaagtctcat tttcgaggct actgatgatg atcagcactt atttcggggt   2220 

ccccatttta cattttccct cggcagtgga agcttacaaa acgactggga agtttccaaa   2280 

atcaatggta ctcatgcccg actgtctacc aggcacacag agtttgagga gagggagtat   2340 

gtcgtcttga tccgcatcaa tgatgggggt cggccaccct tggaaggcat tgtttcttta   2400 

ccagttacat tctgcagttg tgtggaagga agttgtttcc ggccagcagg tcaccagact   2460 

gggataccca ctgtgggcat ggcagttggt atactgctga ccacccttct ggtgattggt   2520 

ataattttag cagttgtgtt tatccgcata aagaaggata aaggcaaaga taatgttgaa   2580 

agtgctcaag catctgaagt caaacctctg agaagctgaa tttgaaaagg aatgtttgaa   2640 

tttatatagc aagtgctatt tcagcaacaa ccatctcatc ctattacttt tcatctaacg   2700 

tgcattataa ttttttaaac agatattccc tcttgtcctt taatatttgc taaatatttc   2760 

ttttttgagg tggagtcttg ctctgtcgcc caggctggag tacagtggtg tgatcccagc   2820 

tcactgcaac ctccgcctcc tgggttcaca tgattctcct gcctcagctt cctaagtagc   2880 

tgggtttaca ggcacccacc accatgccca gctaattttt gtatttttaa tagagacggg   2940 

gtttcgccat ttggccaggc tggtcttgaa ctcctgacgt caagtgatct gcctgccttg   3000 

gtctcccaat acaggcatga accactgcac ccacctactt agatatttca tgtgctatag   3060 

acattagaga gatttttcat ttttccatga catttttcct ctctgcaaat ggcttagcta   3120 

cttgtgtttt tcccttttgg ggcaagacag actcattaaa tattctgtac attttttctt   3180 

tatcaaggag atatatcagt gttgtctcat agaactgcct ggattccatt tatgtttttt   3240 

ctgattccat cctgtgtccc cttcatcctt gactcctttg gtatttcact gaatttcaaa   3300 

catttgtcag agaagaaaaa cgtgaggact caggaaaaat aaataaataa aagaacagcc   3360 

ttttccctta gtattaacag aaatgtttct gtgtcattaa ccatctttaa tcaatgtgac   3420 

atgttgctct ttggctgaaa ttcttcaact tggaaatgac acagacccac agaaggtgtt   3480 

caaacacaac ctactctgca aaccttggta aaggaaccag tcagctggcc agatttcctc   3540 

actacctgcc atgcatacat gctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt   3600 

ggttattata tatttaacat gtggaagaaa acaagacatg aaaagagtgg tgacaaatca   3660 

agaataaaca ctggttgtag tcagttttgt ttgttaa                            3697 

 
           
             16  
             3697  
             DNA  
             human  
           
            16 

agggagtgtt cccgggggag atactccagt cgtagcaaga gtctcgacca ctgaatggaa     60 

gaaaaggact tttaaccacc attttgtgac ttacagaaag gaatttgaat aaagaaaact    120 

atgatacttc aggcccatct tcactccctg tgtcttctta tgctttattt ggcaactgga    180 

tatggccaag aggggaagtt tagtggaccc ctgaaaccca tgacattttc tatttatgaa    240 

ggccaagaac cgagtcaaat tatattccag tttaaggcca atcctcctgc tgtgactttt    300 

gaactaactg gggagacaga caacatattt gtgatagaac gggagggact tctgtattac    360 

aacagagcct tggacaggga aacaagatct actcacaatc tccaggttgc agccctggac    420 

gctaatggaa ttatagtgga gggtccagtc cctatcacca tagaagtgaa ggacatcaac    480 

gacaatcgac ccacgtttct ccagtcaaag tacgaaggct cagtaaggca gaactctcgc    540 

ccaggaaagc ccttcttgta tgtcaatgcc acagacctgg atgatccggc cactcccaat    600 

ggccagcttt attaccagat tgtcatccag cttcccatga tcaacaatgt catgtacttt    660 

cagatcaaca acaaaacggg agccatctct cttacccgag agggatctca ggaattgaat    720 

cctgctaaga atccttccta taatctggtg atctcagtga aggacatggg aggccagagt    780 

gagaattcct tcagtgatac cacatctgtg gatatcatag tgacagagaa tatttggaaa    840 

gcaccaaaac ctgtggagat ggtggaaaac tcaactgatc ctcaccccat caaaatcact    900 

caggtgcggt ggaatgatcc cggtgcacaa tattccttag ttgacaaaga gaagctgcca    960 

agattcccat tttcaattga ccaggaagga gatatttacg tgactcagcc cttggaccga   1020 

gaagaaaagg atgcatatgt tttttatgca gttgcaaagg atgagtacgg aaaaccactt   1080 

tcatatccgc tggaaattca tgtaaaagtt aaagatatta atgataatcc acctacatgt   1140 

ccgtcaccag taaccgtatt tgaggtccag gagaatgaac gactgggtaa cagtatcggg   1200 

acccttactg cacatgacag ggatgaagaa aatactgcca acagttttct aaactacagg   1260 

attgtggagc aaactcccaa acttcccatg gatggactct tcctaatcca aacctatgct   1320 

ggaatgttac agttagctaa acagtccttg aagaagcaag atactcctca gtacaactta   1380 

acgatagagg tgtctgacaa agatttcaag accctttgtt ttgtgcaaat caacgttatt   1440 

gatatcaatg atcagatccc catctttgaa aaatcagatt atggaaacct gactcttgct   1500 

gaagacacaa acattgggtc caccatctta accatccagg ccactgatgc tgatgagcca   1560 

tttactggga gttctaaaat tctgtatcat atcataaagg gagacagtga gggacgcctg   1620 

ggggttgaca cagatcccca taccaacacc ggatatgtca taattaaaaa gcctcttgat   1680 

tttgaaacag cagctgtttc caacattgtg ttcaaagcag aaaatcctga gcctctagtg   1740 

tttggtgtga agtacaatgc aagttctttt gccaagttca cgcttattgt gacagatgtg   1800 

aatgaagcac ctcaattttc ccaacacgta ttccaagcga aagtcagtga ggatgtagct   1860 

ataggcacta aagtgggcaa tgtgactgcc aaggatccag aaggtctgga cataagctat   1920 

tcactgaggg gagacacaag aggttggctt aaaattgacc acgtgactgg tgagatcttt   1980 

agtgtggctc cattggacag agaagccgga agtccatatc gggtacaagt ggtggccaca   2040 

gaagtagggg ggtcttcctt gagctctgtg tcagagttcc acctgatcct tatggatgtg   2100 

aatgacaacc ctcccaggct agccaaggac tacacgggct tgttcttctg ccatcccctc   2160 

agtgcacctg gaagtctcat tttcgaggct actgatgatg atcagcactt atttcggggt   2220 

ccccatttta cattttccct cggcagtgga agcttacaaa acgactggga agtttccaaa   2280 

atcaatggta ctcatgcccg actgtctacc aggcacacag agtttgagga gagggagtat   2340 

gtcgtcttga tccgcatcaa tgatgggggt cggccaccct tggaaggcat tgtttcttta   2400 

ccagttacat tctgcagttg tgtggaagga agttgtttcc ggccagcagg tcaccagact   2460 

gggataccca ctgtgggcat ggcagttggt atactgctga ccacccttct ggtgattggt   2520 

ataattttag cagttgtgtt tatccgcata aagaaggata aaggcaaaga taatgttgaa   2580 

agtgctcaag catctgaagt caaacctctg agaagctgaa tttgaaaagg aatgtttgaa   2640 

tttatatagc aagtgctatt tcagcaacaa ccatctcatc ctattacttt tcatctaacg   2700 

tgcattataa ttttttaaac agatattccc tcttgtcctt taatatttgc taaatatttc   2760 

ttttttgagg tggagtcttg ctctgtcgcc caggctggag tacagtggtg tgatcccagc   2820 

tcactgcaac ctccgcctcc tgggttcaca tgattctcct gcctcagctt cctaagtagc   2880 

tgggtttaca ggcacccacc accatgccca gctaattttt gtatttttaa tagagacggg   2940 

gtttcgccat ttggccaggc tggtcttgaa ctcctgacgt caagtgatct gcctgccttg   3000 

gtctcccaat acaggcatga accactgcac ccacctactt agatatttca tgtgctatag   3060 

acattagaga gatttttcat ttttccatga catttttcct ctctgcaaat ggcttagcta   3120 

cttgtgtttt tcccttttgg ggcaagacag actcattaaa tattctgtac attttttctt   3180 

tatcaaggag atatatcagt gttgtctcat agaactgcct ggattccatt tatgtttttt   3240 

ctgattccat cctgtgtccc cttcatcctt gactcctttg gtatttcact gaatttcaaa   3300 

catttgtcag agaagaaaaa cgtgaggact caggaaaaat aaataaataa aagaacagcc   3360 

ttttccctta gtattaacag aaatgtttct gtgtcattaa ccatctttaa tcaatgtgac   3420 

atgttgctct ttggctgaaa ttcttcaact tggaaatgac acagacccac agaaggtgtt   3480 

caaacacaac ctactctgca aaccttggta aaggaaccag tcagctggcc agatttcctc   3540 

actacctgcc atgcatacat gctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt   3600 

ggttattata tatttaacat gtggaagaaa acaagacatg aaaagagtgg tgacaaatca   3660 

agaataaaca ctggttgtag tcagttttgt ttgttaa                            3697 

 
           
             17  
             1597  
             DNA  
             human  
           
            17 

aacaaactgc acccactgaa ctccgcagct agcatccaaa tcagcccttg agatttgagg     60 

ccttggagac tcaggagttt tgagagcaaa atgacaacac ccagaaattc agtaaatggg    120 

actttcctgg cagagccaat gaaaggccct attgctatgc aatctggtcc aaaaccactc    180 

ttcaggagga tgtcttcact ggtgggcccc acgcaaagct tcttcatgag ggaatctaag    240 

actttggggg ctgtccagat tatgaatggg ctcttccaca ttgccctggg gggtcttctg    300 

atgatcccag cagggatcta tgcacccatc tgtgtgactg tgtggtaccc tctctgggga    360 

ggcattatgt atattatttc cggatcactc ctggcagcaa cggagaaaaa ctccaggaag    420 

tgtttggtca aaggaaaaat gataatgaat tcattgagcc tctttgctgc catttctgga    480 

atgattcttt caatcatgga catacttaat attaaaattt cccatttttt aaaaatggag    540 

agtctgaatt ttattagagc tcacacacca tatattaaca tatacaactg tgaaccagct    600 

aatccctctg agaaaaactc cccatctacc caatactgtt acagcataca atctctgttc    660 

ttgggcattt tgtcagtgat gctgatcttt gccttcttcc aggaacttgt aatagctggc    720 

atcgttgaga atgaatggaa aagaacgtgc tccagaccca aatctaacat agttctcctg    780 

tcagcagaag aaaaaaaaga acagactatt gaaataaaag aagaagtggt tgggctaact    840 

gaaacatctt cccaaccaaa gaatgaagaa gacattgaaa ttattccaat ccaagaagag    900 

gaagaagaag aaacagagac gaactttcca gaacctcccc aagatcagga atcctcacca    960 

atagaaaatg acagctctcc ttaagtgatt tcttctgttt tctgtttcct tttttaaaca   1020 

ttagtgttca tagcttccaa gagacatgct gactttcatt tcttgaggta ctctgcacat   1080 

acgcaccaca tctctatctg gcctttgcat ggagtgacca tagctccttc tctcttacat   1140 

tgaatgtaga gaatgtagcc attgtagcag cttgtgttgt cacgcttctt cttttgagca   1200 

actttcttac actgaagaaa ggcagaatga gtgcttcaga atgtgatttc ctactaacct   1260 

gttccttgga taggcttttt agtatagtat ttttttttgt cattttctcc atcagcaacc   1320 

agggagactg cacctgatgg aaaagatata tgactgcttc atgacattcc taaactatct   1380 

tttttttatt ccacatctac gtttttggtg gagtcccttt tgcatcattg ttttaaggat   1440 

gataaaaaaa aaataacaac tagggacaat acagaaccca ttccatttat ctttctacag   1500 

ggctgacatt gtggcacatt cttagagtta ccacacccca tgagggaagc tctaaatagc   1560 

caacacccat ctgttttttg taaaaacagc atagctt                            1597 

 
           
             18  
             2907  
             DNA  
             human  
           
            18 

gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagccca ccagagcccc     60 

ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccag caacagcagc    120 

tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctcc ctacgccttc    180 

ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccac tctccagcac    240 

cagcttccag ttagtggata tagcacacca tccccagcca ccattgagac ccagagcagc    300 

agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccg catctacaag    360 

ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcag cgcctgtgag    420 

ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg    480 

gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactg ccgactgcag    540 

aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaa caagaagaag    600 

aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccgga ggtgggggag    660 

ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctg ccagctgggc    720 

aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattga cctctgggac    780 

aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgc caagcagctg    840 

cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggc tgcctgcctg    900 

gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacac catgaccttc    960 

tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcgg ccccctcacc   1020 

gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatga tgcggagacg   1080 

gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctgga gcagccggac   1140 

cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgt gcggaagcgg   1200 

aggcccagcc gcccccacat gttccccaag atgctaatga agattactga cctgcgaagc   1260 

atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatccc gggctccatg   1320 

ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactct gagcggacag   1380 

ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcag ctgtagcccc   1440 

agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtg accgcccacg   1500 

ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttct accgaccatg   1560 

tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactgggg accttccctg   1620 

ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccc tcagtggact   1680 

gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactga gtgaggcccc   1740 

tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagaca cccctctgcc   1800 

cagctcacca catcttcatc accagcaaac gccaggactt ggctccccca tcctcagaac   1860 

tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctc ggttggtgac   1920 

agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccat accaacccca   1980 

ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgat ttttttaata   2040 

agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtat tggggggagc   2100 

tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaag gggcccccac   2160 

tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcct cctcagtttt   2220 

ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccc tcccactgga   2280 

gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggt gtggggcagc   2340 

cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgag gcatggagca   2400 

gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcgg cagagctgcc   2460 

tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggg gctggccagg   2520 

ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccataggg cccccagaca   2580 

ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagt agatgggccg   2640 

acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccc caacctgtcc   2700 

cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtct cccctcaccc   2760 

ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccagg ggttggggcc   2820 

ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactg agatctactg   2880 

gataaagaat aaagttctat ttattct                                       2907 

 
           
             19  
             2907  
             DNA  
             human  
           
            19 

gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagccca ccagagcccc     60 

ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccag caacagcagc    120 

tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctcc ctacgccttc    180 

ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccac tctccagcac    240 

cagcttccag ttagtggata tagcacacca tccccagcca ccattgagac ccagagcagc    300 

agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccg catctacaag    360 

ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcag cgcctgtgag    420 

ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg    480 

gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactg ccgactgcag    540 

aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaa caagaagaag    600 

aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccgga ggtgggggag    660 

ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctg ccagctgggc    720 

aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattga cctctgggac    780 

aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgc caagcagctg    840 

cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggc tgcctgcctg    900 

gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacac catgaccttc    960 

tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcgg ccccctcacc   1020 

gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatga tgcggagacg   1080 

gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctgga gcagccggac   1140 

cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgt gcggaagcgg   1200 

aggcccagcc gcccccacat gttccccaag atgctaatga agattactga cctgcgaagc   1260 

atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatccc gggctccatg   1320 

ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactct gagcggacag   1380 

ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcag ctgtagcccc   1440 

agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtg accgcccacg   1500 

ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttct accgaccatg   1560 

tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactgggg accttccctg   1620 

ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccc tcagtggact   1680 

gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactga gtgaggcccc   1740 

tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagaca cccctctgcc   1800 

cagctcacca catcttcatc accagcaaac gccaggactt ggctccccca tcctcagaac   1860 

tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctc ggttggtgac   1920 

agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccat accaacccca   1980 

ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgat ttttttaata   2040 

agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtat tggggggagc   2100 

tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaag gggcccccac   2160 

tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcct cctcagtttt   2220 

ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccc tcccactgga   2280 

gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggt gtggggcagc   2340 

cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgag gcatggagca   2400 

gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcgg cagagctgcc   2460 

tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggg gctggccagg   2520 

ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccataggg cccccagaca   2580 

ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagt agatgggccg   2640 

acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccc caacctgtcc   2700 

cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtct cccctcaccc   2760 

ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccagg ggttggggcc   2820 

ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactg agatctactg   2880 

gataaagaat aaagttctat ttattct                                       2907 

 
           
             20  
             1347  
             DNA  
             human  
           
            20 

atggatccca aatatttcat cttaattttg ttttgtggac acctgaacaa tacatttttt     60 

tcaaagacag agacaattac aacagagaag cagtcacagc ctaccttata cacatcatca    120 

atgtcacagg tattggctaa ttctcaaaac acaacaggga atcctttggg tcaaccaaca    180 

caattcagcg acactttttc tggacaatca atatcacctg ccaaagtcac tgctggacaa    240 

ccaacaccag ctgtctatac ctcttctgaa aaaccagaag cacatacttc tgctggacaa    300 

ccacttgcct acaacaccaa acaaccaaca ccaatagcca acacctcctc ccagcaagcc    360 

gtgttcacct ctgccagaca actaccatct gcccgtactt ctaccacaca accaccaaag    420 

tcatttgtct atacttttac tcaacaatca tcatctgtcc agatcccttc tagaaaacaa    480 

ataactgttc ataatccatc cacacaacca acatcaactg tcaaaaattc acctaggagt    540 

acaccaggat ttatcttaga tactaccagt aacaaacaaa ccccacaaaa aaacaattat    600 

aattcaatag ctgccatact aattggtgta cttctgactt ctatgttggt agctataatc    660 

atcattgtac tttggaaatg cttaaggaaa ccagttttaa atgatcaaaa ttgggcaggt    720 

agatctccat ttgctgatgg agaaacccct gacatttgta tggataacat cagagaaaat    780 

gaaatatcca caaaacgtac atcaatcatt tcacttacac cctggaaacc aagcaaaagc    840 

acacttttag cagatgactt agaaattaag ttgtttgaat caagtgaaaa cattgaagac    900 

tccaacaacc ccaaaacaga gaaaataaaa gatcaagtaa atggtacatc agaagatagt    960 

gctgatggtt caacagttgg aactgctgtt tcttcttcag atgatgcaga tctgcctcca   1020 

ccacctcccc ttctggattt ggaaggacag gaaagtaacc aatctgacaa acccacaatg   1080 

acaattgtat ctcctcttcc aaatgattct actagtctcc ctccatctct ggactgtctc   1140 

aatcaagact gtggagatca taaatctgag ataatacaat catttccacc gcttgactca   1200 

cttaacttgc ccctgccacc agtagatttt atgaaaaacc aagaagattc caaccttgag   1260 

atccagtgtc aggagttctc tattcctccc aactctgatc aagatcttaa tgaatccctg   1320 

ccacctccac ctgcagaact gttataa                                       1347 

 
           
             21  
             2170  
             DNA  
             human  
           
            21 

ctgagggctc atccctctgc agagcgcggg gtcaccggga ggagacgcca tgacgcccgc     60 

cctcacagcc ctgctctgcc ttgggctgag tctgggcccc aggacccgcg tgcaggcagg    120 

gcccttcccc aaacccaccc tctgggctga gccaggctct gtgatcagct gggggagccc    180 

cgtgaccatc tggtgtcagg ggagcctgga ggcccaggag taccgactgg ataaagaggg    240 

aagcccagag cccttggaca gaaataaccc actggaaccc aagaacaagg ccagattctc    300 

catcccatcc atgacagagc accatgcggg gagataccgc tgccactatt acagctctgc    360 

aggctggtca gagcccagcg accccctgga gctggtgatg acaggattct acaacaaacc    420 

caccctctca gccctgccca gccctgtggt ggcctcaggg gggaatatga ccctccgatg    480 

tggctcacag aagggatatc accattttgt tctgatgaag gaaggagaac accagctccc    540 

ccggaccctg gactcacagc agctccacag tggggggttc caggccctgt tccctgtggg    600 

ccccgtgaac cccagccaca ggtggaggtt cacatgctat tactattata tgaacacccc    660 

ccaggtgtgg tcccacccca gtgaccccct ggagattctg ccctcaggcg tgtctaggaa    720 

gccctccctc ctgaccctgc agggccctgt cctggcccct gggcagagcc tgaccctcca    780 

gtgtggctct gatgtcggct acgacagatt tgttctgtat aaggaggggg aacgtgactt    840 

cctccagcgc cctggccagc agccccaggc tgggctctcc caggccaact tcaccctggg    900 

ccctgtgagc ccctcccacg ggggccagta caggtgctat ggtgcacaca acctctcctc    960 

cgagtggtcg gcccccagcg accccctgaa catcctgatg gcaggacaga tctatgacac   1020 

cgtctccctg tcagcacagc cgggccccac agtggcctca ggagagaacg tgaccctgct   1080 

gtgtcagtca tggtggcagt ttgacacttt ccttctgacc aaagaagggg cagcccatcc   1140 

cccactgcgt ctgagatcaa tgtacggagc tcataagtac caggctgaat tccccatgag   1200 

tcctgtgacc tcagcccacg cggggaccta caggtgctac ggctcataca gctccaaccc   1260 

ccacctgctg tctttcccca gtgagcccct ggaactcatg gtctcaggac actctggagg   1320 

ctccagcctc ccacccacag ggccgccctc cacacctggt ctgggaagat acctggaggt   1380 

tttgattggg gtctcggtgg ccttcgtcct gctgctcttc ctcctcctct tcctcctcct   1440 

ccgacgtcag cgtcacagca aacacaggac atctgaccag agaaagactg atttccagcg   1500 

tcctgcaggg gctgcggaga cagagcccaa ggacaggggc ctgctgagga ggtccagccc   1560 

agctgctgac gtccaggaag aaaacctcta tgctgccgtg aaggacacac agtctgagga   1620 

cagggtggag ctggacagtc agagcccaca cgatgaagac ccccaggcag tgacgtatgc   1680 

cccggtgaaa cactccagtc ctaggagaga aatggcctct cctccctcct cactgtctgg   1740 

ggaattcctg gacacaaagg acagacaggt ggaagaggac aggcagatgg acactgaggc   1800 

tgctgcatct gaagcctccc aggatgtgac ctacgcccag ctgcacagct tgacccttag   1860 

acggaaggca actgagcctc ctccatccca ggaaggggaa cctccagctg agcccagcat   1920 

ctacgccact ctggccatcc actagcccgg ggggtacgca gaccccacac tcagcagaag   1980 

gagactcagg actgctgaag gcacgggagc tgcccccagt ggacaccagt gaaccccagt   2040 

cagcctggac ccctaacaca gaccatgagg agacgctggg aacttgtggg actcacctga   2100 

ctcaaagatg actaatatcg tcccattttg gaaataaagc aacagacttc tcaacaatca   2160 

atgagttaat                                                          2170 

 
           
             22  
             1453  
             DNA  
             human  
           
            22 

gggagtgcat ccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat     60 

acgagcagcg tggccgttgg ctgcctcgca caggacttcc ttcccgactc catcactttc    120 

tcctggaaat acaagaacaa ctctgacatc agcagcaccc ggggcttccc atcagtcctg    180 

agagggggca agtacgcagc cacctcacag gtgctgctgc cttccaagga cgtcatgcag    240 

ggcacagacg aacacgtggt gtgcaaagtc cagcacccca acggcaacaa agaaaagaac    300 

gtgcctcttc cagtgattgc cgagctgcct cccaaagtga gcgtcttcgt cccaccccgc    360 

gacggcttct tcggcaaccc ccgcaagtcc aagctcatct gccaggccac gggtttcagt    420 

ccccggcaga ttcaggtgtc ctggctgcgc gaggggaagc aggtggggtc tggcgtcacc    480 

acggaccagg tgcaggctga ggccaaagag tctgggccca cgacctacaa ggtgaccagc    540 

acactgacca tcaaagagag cgactggctc agccagagca tgttcacctg ccgcgtggat    600 

cacaggggcc tgaccttcca gcagaatgcg tcctccatgt gtgtccccga tcaagacaca    660 

gccatccggg tcttcgccat ccccccatcc tttgccagca tcttcctcac caagtccacc    720 

aagttgacct gcctggtcac agacctgacc acctatgaca gcgtgaccat ctcctggacc    780 

cgccagaatg gcgaagctgt gaaaacccac accaacatct ccgagagcca ccccaatgcc    840 

actttcagcg ccgtgggtga ggccagcatc tgcgaggatg actggaattc cggggagagg    900 

ttcacgtgca ccgtgaccca cacagacctg ccctcgccac tgaagcagac catctcccgg    960 

cccaaggggg tggccctgca caggcccgat gtctacttgc tgccaccagc ccgggagcag   1020 

ctgaacctgc gggagtcggc caccatcacg tgcctggtga cgggcttctc tcccgcggac   1080 

gtcttcgtgc agtggatgca gagggggcag cccttgtccc cggagaagta tgtgaccagc   1140 

gccccaatgc ctgagcccca ggccccaggc cggtacttcg cccacagcat cctgaccgtg   1200 

tccgaagagg aatggaacac gggggagacc tacacctgcg tggtggccca tgaggccctg   1260 

cccaacaggg tcaccgagag gaccgtggac aagtccaccg gtaaacccac cctgtacaac   1320 

gtgtccctgg tcatgtccga cacagctggc acctgctact gaccctgctg gcctgcccac   1380 

aggctcgggg cggctggccg ctctgtgtgt gcatgcaaac taacccgtgt caacggggtg   1440 

agatgttgca tct                                                      1453 

 
           
             23  
             1192  
             DNA  
             human  
           
            23 

cagatccatc aggtccaagc tgtgttgact accactgctt ttcccttcgt ctcaattatg     60 

tcttggaaga aggctttgcg gatccctgga ggccttcggg tagcaactgt gaccttgatg    120 

ctggcgatgc tgagcacccc ggtggctgag ggcagagact ctcccgagga tttcgtgtac    180 

cagtttaagg gcatgtgcta cttcaccaac gggacggagc gcgtgcgtct tgtgaccaga    240 

tacatctata accgagagga gtacgcacgc ttcgacagcg acgtgggggt gtatcgggcg    300 

gtgacgccgc tggggccgcc tgacgccgag tactggaaca gccagaagga agtcctggag    360 

aggacccggg cggagttgga cacggtgtgc agacacaact accagttgga gctccgcacg    420 

accttgcagc ggcgagtgga gcccacagtg accatctccc catccaggac agaggccctc    480 

aaccaccaca acctgctggt ctgctcagtg acagatttct atccagccca gatcaaagtc    540 

cggtggtttc ggaatgacca ggaggagaca actggcgttg tgtccacccc ccttattagg    600 

aacggtgact ggaccttcca gatcctggtg atgctggaaa tgactcccca gcgtggagac    660 

gtctacacct gccacgtgga gcaccccagc ctccagaacc ccatcatcgt ggagtggcgg    720 

gctcagtctg aatctgccca gagcaagatg ctgagtggca ttggaggctt cgtgctgggg    780 

ctgatcttcc tcgggctggg ccttattatc catcacagga gtcagaaagg gctcctgcac    840 

tgactcctga gactatttta actgggattg gttatcactt ttctgtaacg cctgcttgtc    900 

cctgcccaga attcccagct gcctgtgtca gcctgtcccc cgagatcaga gtcctaccgt    960 

ggctgtcacg cagccaccag gtcatctcct ttcatcccca cctcaaggct gatggctgtg   1020 

accctgcttc ctgcactgac ccagagcctc tgcctgtgca cggccagctg cgtctactga   1080 

ggccccaagg ggtttctgtt tctattctct cctcagactg ctcaagagaa gcacatgaaa   1140 

accattacct gactttagag cttttttaca taattaaaca tgatcctgag tt           1192 

 
           
             24  
             2048  
             DNA  
             human  
           
            24 

atgtgaaggc acaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa     60 

gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt    120 

tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat    180 

agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg    240 

tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg    300 

acatgaggca actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg    360 

tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc    420 

agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac    480 

caccagattt acatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac    540 

cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga    600 

gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg    660 

caaggtcaaa cctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt    720 

catcatgggc tgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga    780 

caaatttgag aaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac    840 

caaacccatc agtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga    900 

agttattggg catcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg    960 

gaccagcgtg gttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt   1020 

gctcttcact ggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga   1080 

tgtcccaaaa ctagtgactg agttcctggc aaagaaattt gacctggacc agttgataac   1140 

tcatgtttta ccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag   1200 

cattcgaacg gtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt   1260 

gaactggagt ttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat   1320 

acaagcataa gtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt   1380 

tataaacatt taaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt   1440 

ttgatttaca ttttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc   1500 

tatgttgaaa tggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa   1560 

cagatatagc gtataaagat atagtaaatg catctcccag agtaatattc acttaacaca   1620 

ttgaaactat tattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt   1680 

taacttggat tacattttga aatcagttca ttccatgatg catattactg gattagatta   1740 

agaaagacag aaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac   1800 

ataacttggt gaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata   1860 

tattaatatt ttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc   1920 

atattatcat acttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc   1980 

cctattcact gtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa   2040 

ctaaaccg                                                            2048 

 
           
             25  
             2048  
             DNA  
             human  
           
            25 

atgtgaaggc acaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa     60 

gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt    120 

tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat    180 

agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg    240 

tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg    300 

acatgaggca actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg    360 

tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc    420 

agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac    480 

caccagattt acatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac    540 

cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga    600 

gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg    660 

caaggtcaaa cctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt    720 

catcatgggc tgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga    780 

caaatttgag aaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac    840 

caaacccatc agtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga    900 

agttattggg catcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg    960 

gaccagcgtg gttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt   1020 

gctcttcact ggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga   1080 

tgtcccaaaa ctagtgactg agttcctggc aaagaaattt gacctggacc agttgataac   1140 

tcatgtttta ccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag   1200 

cattcgaacg gtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt   1260 

gaactggagt ttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat   1320 

acaagcataa gtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt   1380 

tataaacatt taaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt   1440 

ttgatttaca ttttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc   1500 

tatgttgaaa tggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa   1560 

cagatatagc gtataaagat atagtaaatg catctcccag agtaatattc acttaacaca   1620 

ttgaaactat tattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt   1680 

taacttggat tacattttga aatcagttca ttccatgatg catattactg gattagatta   1740 

agaaagacag aaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac   1800 

ataacttggt gaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata   1860 

tattaatatt ttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc   1920 

atattatcat acttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc   1980 

cctattcact gtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa   2040 

ctaaaccg                                                            2048 

 
           
             26  
             2816  
             DNA  
             human  
           
            26 

tcgttgatat caaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct     60 

acagtactgc cctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg    120 

aaagaaagtt attaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt    180 

ccagaggttt tccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc    240 

attgacttga actttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt    300 

agcatggact gtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac    360 

acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc    420 

agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag    480 

cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac    540 

ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc    600 

tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc    660 

cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac    720 

aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt    780 

gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc    840 

catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag    900 

ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt    960 

tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat   1020 

gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac   1080 

aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt   1140 

gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag   1200 

aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat   1260 

gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca   1320 

attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc   1380 

ctttcagcct gcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct   1440 

gacgtcttct ttagacattc caagccccca aaccgatcag tgtacccata gagccctatc   1500 

tctatatttt aagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta   1560 

tgtgtgtgcg tgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga   1620 

cccaactgct caaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct   1680 

ttacaagaaa ggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag   1740 

gaaccactgt gtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg   1800 

gaaaggggca ttaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa   1860 

aattcacagg gaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag   1920 

aaaaaagttg ttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga   1980 

cccttttaat gctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg   2040 

tactgctggg cagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc   2100 

tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat   2160 

gctgtgtacc tgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta   2220 

catgaaaccc tggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa   2280 

ctcattttgt gcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt   2340 

tgtttaccat tattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt   2400 

aatttgctta attagagctt ctatccctca agcctaccta ccataaaacc agccatatta   2460 

ctgatactgt tcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc   2520 

agacgtgtta aaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt   2580 

ttcttttttt tactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt   2640 

ttaagataat agcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt   2700 

caccagcact gtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt   2760 

ttgtggatgt gtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa       2816 

 
           
             27  
             2816  
             DNA  
             human  
           
            27 

tcgttgatat caaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct     60 

acagtactgc cctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg    120 

aaagaaagtt attaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt    180 

ccagaggttt tccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc    240 

attgacttga actttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt    300 

agcatggact gtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac    360 

acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc    420 

agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag    480 

cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac    540 

ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc    600 

tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc    660 

cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac    720 

aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt    780 

gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc    840 

catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag    900 

ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt    960 

tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat   1020 

gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac   1080 

aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt   1140 

gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag   1200 

aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat   1260 

gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca   1320 

attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc   1380 

ctttcagcct gcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct   1440 

gacgtcttct ttagacattc caagccccca aaccgatcag tgtacccata gagccctatc   1500 

tctatatttt aagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta   1560 

tgtgtgtgcg tgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga   1620 

cccaactgct caaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct   1680 

ttacaagaaa ggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag   1740 

gaaccactgt gtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg   1800 

gaaaggggca ttaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa   1860 

aattcacagg gaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag   1920 

aaaaaagttg ttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga   1980 

cccttttaat gctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg   2040 

tactgctggg cagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc   2100 

tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat   2160 

gctgtgtacc tgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta   2220 

catgaaaccc tggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa   2280 

ctcattttgt gcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt   2340 

tgtttaccat tattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt   2400 

aatttgctta attagagctt ctatccctca agcctaccta ccataaaacc agccatatta   2460 

ctgatactgt tcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc   2520 

agacgtgtta aaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt   2580 

ttcttttttt tactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt   2640 

ttaagataat agcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt   2700 

caccagcact gtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt   2760 

ttgtggatgt gtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa       2816 

 
           
             28  
             3803  
             DNA  
             human  
           
            28 

ccatggtagg agcgctcgcc tcgctgcggt gcccgctgag gccatgccgg ggccccggcg     60 

ccccgctggc tcccgcctgc gcctgctcct gctcctgctg ctgccgccgc tgctgctgct    120 

gctccggggc agccacgcgg gcaacctgac ggtagccgtg gtactgccgc tggccaatac    180 

ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtg gagctggccc tggcccaggt    240 

gaaggcgcgc cccgacttgc tgccgggctg gacggtccgc acggtgctgg gcagcagcga    300 

aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctg gccgcggtgg acctcaagtg    360 

ggagcacaac cccgctgtgt tcctgggccc cggctgcgtg tacgccgccg ccccagtggg    420 

gcgcttcacc gcgcactggc gggtcccgct gctgaccgcc ggcgccccgg cgctgggctt    480 

cggtgtcaag gacgagtatg cgctgaccac ccgcgcgggg cccagctacg ccaagctggg    540 

ggacttcgtg gcggcgctgc accgacggct gggctgggag cgccaagcgc tcatgctcta    600 

cgcctaccgg ccgggtgacg aagagcactg cttcttcctc gtggaggggc tgttcatgcg    660 

ggtccgcgac cgcctcaata ttacggtgga ccacctggag ttcgccgagg acgacctcag    720 

ccactacacc aggctgctgc ggaccatgcc gcgcaaaggc cgagttatct acatctgcag    780 

ctcccctgat gccttcagaa ccctcatgct cctggccctg gaagctggct tgtgtgggga    840 

ggactacgtt ttcttccacc tggatatctt tgggcaaagc ctgcaaggtg gacagggccc    900 

tgctccccgc aggccctggg agagagggga tgggcaggat gtcagtgccc gccaggcctt    960 

tcaggctgcc aaaatcatta catataaaga cccagataat cccgagtact tggaattcct   1020 

gaagcagtta aaacacctgg cctatgagca gttcaacttc accatggagg atggcctggt   1080 

gaacaccatc ccagcatcct tccacgacgg gctcctgctc tatatccagg cagtgacgga   1140 

gactctggca catgggggaa ctgttactga tggggagaac atcactcagc ggatgtggaa   1200 

ccgaagcttt caaggtgtga caggatacct gaaaattgat agcagtggcg atcgggaaac   1260 

agacttctcc ctctgggata tggatcccga gaatggtgcc ttcagggttg tactgaacta   1320 

caatgggact tcccaagagc tggtggctgt gtcggggcgc aaactgaact ggcccctggg   1380 

gtaccctcct cctgacatcc ccaaatgtgg ctttgacaac gaagacccag catgcaacca   1440 

agatcacctt tccaccctgg aggtgctggc tttggtgggc agcctctcct tgctcggcat   1500 

tctgattgtc tccttcttca tatacaggaa gatgcagctg gagaaggaac tggcctcgga   1560 

gctgtggcgg gtgcgctggg aggacgttga gcccagtagc cttgagaggc acctgcggag   1620 

tgcaggcagc cggctgaccc tgagcgggag aggctccaat tacggctccc tgctaaccac   1680 

agagggccag ttccaagtct ttgccaagac agcatattat aagggcaacc tcgtggctgt   1740 

gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaa gtcctgtttg aactgaagca   1800 

tatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgca ccgacccccc   1860 

caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggaca ttctggagaa   1920 

tgagagcatc accctggact ggatgttccg gtactcactc accaatgaca tcgtcaaggg   1980 

catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagt catccaactg   2040 

cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggaga gcttcaggga   2100 

cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacgg cccctgagct   2160 

cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtat acagctttgg   2220 

gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaag gtttggacct   2280 

gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagcccccct tccggccctc   2340 

cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggt gctgggctga   2400 

ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgca aatttaacag   2460 

ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagt acgcgaacaa   2520 

tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagc gcaaggctga   2580 

ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagc gtggggagac   2640 

ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattg tgggtttcac   2700 

agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatg acctgtacac   2760 

ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaa ttggcgatgc   2820 

ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc   2880 

ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgcc accggcccca   2940 

ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctg gagtggtggg   3000 

actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcct caagaatgga   3060 

gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctg tcctggagga   3120 

gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggca aaggcaaggt   3180 

tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgac ctgcctcctc   3240 

tcctatccct ccacacctcc cctaccctgt gccagaagca acagaggtgc caggcctcag   3300 

cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagc tcaggtgtgc   3360 

tgaccccagt gaagacacca gataggacct ctgagagggg actggcatgg ggggatctca   3420 

gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacac aggcacacgc   3480 

acctgctctc cacctggact caggccgggc tgggctgtgg atccttgatc ccctcccctc   3540 

cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggag agtcacctga   3600 

aggggaacat gaaaagagac taggtgaaga gagggcaggg gagcccacat ctggggctgg   3660 

cccacaatac ctgctccccc gaccccctcc acccagcagt agacacagtg cacaggggag   3720 

aagaggggtg gcgcagaagg gttgggggcc tgtatgcctt gcttctacca tgagcagaga   3780 

caattaaaat ctttattcca gtg                                           3803 

 
           
             29  
             3803  
             DNA  
             human  
           
            29 

ccatggtagg agcgctcgcc tcgctgcggt gcccgctgag gccatgccgg ggccccggcg     60 

ccccgctggc tcccgcctgc gcctgctcct gctcctgctg ctgccgccgc tgctgctgct    120 

gctccggggc agccacgcgg gcaacctgac ggtagccgtg gtactgccgc tggccaatac    180 

ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtg gagctggccc tggcccaggt    240 

gaaggcgcgc cccgacttgc tgccgggctg gacggtccgc acggtgctgg gcagcagcga    300 

aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctg gccgcggtgg acctcaagtg    360 

ggagcacaac cccgctgtgt tcctgggccc cggctgcgtg tacgccgccg ccccagtggg    420 

gcgcttcacc gcgcactggc gggtcccgct gctgaccgcc ggcgccccgg cgctgggctt    480 

cggtgtcaag gacgagtatg cgctgaccac ccgcgcgggg cccagctacg ccaagctggg    540 

ggacttcgtg gcggcgctgc accgacggct gggctgggag cgccaagcgc tcatgctcta    600 

cgcctaccgg ccgggtgacg aagagcactg cttcttcctc gtggaggggc tgttcatgcg    660 

ggtccgcgac cgcctcaata ttacggtgga ccacctggag ttcgccgagg acgacctcag    720 

ccactacacc aggctgctgc ggaccatgcc gcgcaaaggc cgagttatct acatctgcag    780 

ctcccctgat gccttcagaa ccctcatgct cctggccctg gaagctggct tgtgtgggga    840 

ggactacgtt ttcttccacc tggatatctt tgggcaaagc ctgcaaggtg gacagggccc    900 

tgctccccgc aggccctggg agagagggga tgggcaggat gtcagtgccc gccaggcctt    960 

tcaggctgcc aaaatcatta catataaaga cccagataat cccgagtact tggaattcct   1020 

gaagcagtta aaacacctgg cctatgagca gttcaacttc accatggagg atggcctggt   1080 

gaacaccatc ccagcatcct tccacgacgg gctcctgctc tatatccagg cagtgacgga   1140 

gactctggca catgggggaa ctgttactga tggggagaac atcactcagc ggatgtggaa   1200 

ccgaagcttt caaggtgtga caggatacct gaaaattgat agcagtggcg atcgggaaac   1260 

agacttctcc ctctgggata tggatcccga gaatggtgcc ttcagggttg tactgaacta   1320 

caatgggact tcccaagagc tggtggctgt gtcggggcgc aaactgaact ggcccctggg   1380 

gtaccctcct cctgacatcc ccaaatgtgg ctttgacaac gaagacccag catgcaacca   1440 

agatcacctt tccaccctgg aggtgctggc tttggtgggc agcctctcct tgctcggcat   1500 

tctgattgtc tccttcttca tatacaggaa gatgcagctg gagaaggaac tggcctcgga   1560 

gctgtggcgg gtgcgctggg aggacgttga gcccagtagc cttgagaggc acctgcggag   1620 

tgcaggcagc cggctgaccc tgagcgggag aggctccaat tacggctccc tgctaaccac   1680 

agagggccag ttccaagtct ttgccaagac agcatattat aagggcaacc tcgtggctgt   1740 

gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaa gtcctgtttg aactgaagca   1800 

tatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgca ccgacccccc   1860 

caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggaca ttctggagaa   1920 

tgagagcatc accctggact ggatgttccg gtactcactc accaatgaca tcgtcaaggg   1980 

catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagt catccaactg   2040 

cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggaga gcttcaggga   2100 

cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacgg cccctgagct   2160 

cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtat acagctttgg   2220 

gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaag gtttggacct   2280 

gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagcccccct tccggccctc   2340 

cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggt gctgggctga   2400 

ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgca aatttaacag   2460 

ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagt acgcgaacaa   2520 

tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagc gcaaggctga   2580 

ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagc gtggggagac   2640 

ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattg tgggtttcac   2700 

agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatg acctgtacac   2760 

ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaa ttggcgatgc   2820 

ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc   2880 

ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgcc accggcccca   2940 

ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctg gagtggtggg   3000 

actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcct caagaatgga   3060 

gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctg tcctggagga   3120 

gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggca aaggcaaggt   3180 

tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgac ctgcctcctc   3240 

tcctatccct ccacacctcc cctaccctgt gccagaagca acagaggtgc caggcctcag   3300 

cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagc tcaggtgtgc   3360 

tgaccccagt gaagacacca gataggacct ctgagagggg actggcatgg ggggatctca   3420 

gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacac aggcacacgc   3480 

acctgctctc cacctggact caggccgggc tgggctgtgg atccttgatc ccctcccctc   3540 

cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggag agtcacctga   3600 

aggggaacat gaaaagagac taggtgaaga gagggcaggg gagcccacat ctggggctgg   3660 

cccacaatac ctgctccccc gaccccctcc acccagcagt agacacagtg cacaggggag   3720 

aagaggggtg gcgcagaagg gttgggggcc tgtatgcctt gcttctacca tgagcagaga   3780 

caattaaaat ctttattcca gtg                                           3803 

 
           
             30  
             2970  
             DNA  
             human  
           
            30 

ggggtaagga gttcaaggca gcgcccacac ccgggggctc tccgcaaccc gaccgcctgt     60 

ccgctccccc acttcccgcc ctccctccca cctactcatt cacccaccca cccacccaga    120 

gccgggacgg cagcccaggc gcccgggccc cgccgtctcc tcgccgcgat cctggacttc    180 

ctcttgctgc aggacccggc ttccacgtgt gtcccggagc cggcgtctca gcacacgctc    240 

cgctccgggc ctgggtgcct acagcagcca gagcagcagg gagtccggga cccgggcggc    300 

atctgggcca agttaggcgc cgccgaggcc agcgctgaac gtctccaggg ccggaggagc    360 

cgcggggcgt ccgggtctga gcctcagcaa atgggctccg acgtgcggga cctgaacgcg    420 

ctgctgcccg ccgtcccctc cctgggtggc ggcggcggct gtgccctgcc tgtgagcggc    480 

gcggcgcagt gggcgccggt gctggacttt gcgcccccgg gcgcttcggc ttacgggtcg    540 

ttgggcggcc ccgcgccgcc accggctccg ccgccacccc cgccgccgcc gcctcactcc    600 

ttcatcaaac aggagccgag ctggggcggc gcggagccgc acgaggagca gtgcctgagc    660 

gccttcactg tccacttttc cggccagttc actggcacag ccggagcctg tcgctacggg    720 

cccttcggtc ctcctccgcc cagccaggcg tcatccggcc aggccaggat gtttcctaac    780 

gcgccctacc tgcccagctg cctcgagagc cagcccgcta ttcgcaatca gggttacagc    840 

acggtcacct tcgacgggac gcccagctac ggtcacacgc cctcgcacca tgcggcgcag    900 

ttccccaacc actcattcaa gcatgaggat cccatgggcc agcagggctc gctgggtgag    960 

cagcagtact cggtgccgcc cccggtctat ggctgccaca cccccaccga cagctgcacc   1020 

ggcagccagg ctttgctgct gaggacgccc tacagcagtg acaatttata ccaaatgaca   1080 

tcccagcttg aatgcatgac ctggaatcag atgaacttag gagccacctt aaagggccac   1140 

agcacagggt acgagagcga taaccacaca acgcccatcc tctgcggagc ccaatacaga   1200 

atacacacgc acggtgtctt cagaggcatt caggatgtgc gacgtgtgcc tggagtagcc   1260 

ccgactcttg tacggtcggc atctgagacc agtgagaaac gccccttcat gtgtgcttac   1320 

ccaggctgca ataagagata ttttaagctg tcccacttac agatgcacag caggaagcac   1380 

actggtgaga aaccatacca gtgtgacttc aaggactgtg aacgaaggtt ttctcgttca   1440 

gaccagctca aaagacacca aaggagacat acaggtgtga aaccattcca gtgtaaagct   1500 

tgtcagcgaa agttctcccg gtccgaccac ctgaagaccc acaccaggac tcatacaggt   1560 

gaaaagccct tcagctgtcg gtggccaagt tgtcagaaaa agtttgcccg gtcagatgaa   1620 

ttagtccgcc atcacaacat gcatcagaga aacatgacca aactccagct ggcgctttga   1680 

ggggtctccc tcggggaccg ttcagtgtcc caggcagcac agtgtgtgaa ctgctttcaa   1740 

gtctgactct ccactcctcc tcactaaaaa ggaaacttca gttgatcttc ttcatccaac   1800 

ttccaagaca agataccggt gcttctggaa actaccaggt gtgcctggaa gagttggtct   1860 

ctgccctgcc tacttttagt tgactcacag gccctggaga agcagctaac aatgtctggt   1920 

tagttaaaag cccattgcca tttggtctgg attttctact gtaagaagag ccatagctga   1980 

tcatgtcccc ctgacccttc ccttcttttt ttatgctcgt tttcgctggg gatggaatta   2040 

ttgtaccatt ttctatcatg gaatatttat aggccagggc atgtgtatgt gtctgctaat   2100 

gtaaactttg tcatggtttc catttactaa cagcaacagc aagaaataaa tcagagagca   2160 

aggcatcggg ggtgaatctt gtctaacatt cccgaggtca gccaggctgc taacctggaa   2220 

agcaggatgt agttctgcca ggcaactttt aaagctcatg catttcaagc agctgaagaa   2280 

agaatcagaa ctaaccagta cctctgtata gaaatctaaa agaattttac cattcagtta   2340 

attcaatgtg aacactggca cactgctctt aagaaactat gaagatctga gatttttttg   2400 

tgtatgtttt tgactctttt gagtggtaat catatgtgtc tttatagatg tacatacctc   2460 

cttgcacaaa tggaggggaa ttcattttca tcactgggag tgtccttagt gtataaaaac   2520 

catgctggta tatggcttca agttgtaaaa atgaaagtga ctttaaaaga aaatagggga   2580 

tggtccagga tctccactga taagactgtt tttaagtaac ttaaggacct ttgggtctac   2640 

aagtatatgt gaaaaaaatg agacttactg ggtgaggaaa tccattgttt aaagatggtc   2700 

gtgtgtgtgt gtgtgtgtgt gtgtgtgttg tgttgtgttt tgttttttaa gggagggaat   2760 

ttattattta ccgttgcttg aaattactgt gtaaatatat gtctgataat gatttgctct   2820 

ttgacaacta aaattaggac tgtataagta ctagatgcat cactgggtgt tgatcttaca   2880 

agatattgat gataacactt aaaattgtaa cctgcatttt tcactttgct ctcaattaaa   2940 

gtctattcaa aaggaaaaaa aaaaaaaaaa                                    2970 

 
           
             31  
             2422  
             DNA  
             human  
           
            31 

gtcagcctcc cttccaccgc catattgggc cactaaaaaa agggggctcg tcttttcggg     60 

gtgtttttct ccccctcccc tgtccccgct tgctcacggc tctgcgactc cgacgccggc    120 

aaggtttgga gagcggctgg gttcgcggga cccgcgggct tgcacccgcc cagactcgga    180 

cgggctttgc caccctctcc gcttgcctgg tcccctctcc tctccgccct cccgctcgcc    240 

agtccatttg atcagcggag actcggcggc cgggccgggg cttccccgca gcccctgcgc    300 

gctcctagag ctcgggccgt ggctcgtcgg ggtctgtgtc ttttggctcc gagggcagtc    360 

gctgggcttc cgagaggggt tcgggccgcg taggggcgct ttgttttgtt cggttttgtt    420 

tttttgagag tgcgagagag gcggtcgtgc agacccggga gaaagatgtc aaacgtgcga    480 

gtgtctaacg ggagccctag cctggagcgg atggacgcca ggcaggcgga gcaccccaag    540 

ccctcggcct gcaggaacct cttcggcccg gtggaccacg aagagttaac ccgggacttg    600 

gagaagcact gcagagacat ggaagaggcg agccagcgca agtggaattt cgattttcag    660 

aatcacaaac ccctagaggg caagtacgag tggcaagagg tggagaaggg cagcttgccc    720 

gagttctact acagaccccc gcggcccccc aaaggtgcct gcaaggtgcc ggcgcaggag    780 

agccaggatg tcagcgggag ccgcccggcg gcgcctttaa ttggggctcc ggctaactct    840 

gaggacacgc atttggtgga cccaaagact gatccgtcgg acagccagac ggggttagcg    900 

gagcaatgcg caggaataag gaagcgacct gcaaccgacg attcttctac tcaaaacaaa    960 

agagccaaca gaacagaaga aaatgtttca gacggttccc caaatgccgg ttctgtggag   1020 

cagacgccca agaagcctgg cctcagaaga cgtcaaacgt aaacagctcg aattaagaat   1080 

atgtttcctt gtttatcaga tacatcactg cttgatgaag caaggaagat atacatgaaa   1140 

attttaaaaa tacatatcgc tgacttcatg gaatggacat cctgtataag cactgaaaaa   1200 

caacaacaca ataacactaa aattttaggc actcttaaat gatctgcctc taaaagcgtt   1260 

ggatgtagca ttatgcaatt aggtttttcc ttatttgctt cattgtacta cctgtgtata   1320 

tagtttttac cttttatgta gcacataaac tttggggaag ggagggcagg gtggggctga   1380 

ggaactgacg tggagcgggg tatgaagagc ttgctttgat ttacagcaag tagataaata   1440 

tttgacttgc atgaagagaa gcaattttgg ggaagggttt gaattgtttt ctttaaagat   1500 

gtaatgtccc tttcagagac agctgatact tcatttaaaa aaatcacaaa aatttgaaca   1560 

ctggctaaag ataattgcta tttattttta caagaagttt attctcattt gggagatctg   1620 

gtgatctccc aagctatcta aagtttgtta gatagctgca tgtggctttt ttaaaaaagc   1680 

aacagaaacc tatcctcact gccctcccca gtctctctta aagttggaat ttaccagtta   1740 

attactcagc agaatggtga tcactccagg tagtttgggg caaaaatccg aggtgcttgg   1800 

gagttttgaa tgttaagaat tgaccatctg cttttattaa atttgttgac aaaattttct   1860 

cattttcttt tcacttcggg ctgtgtaaac acagtcaaaa taattctaaa tccctcgata   1920 

tttttaaaga tctgtaagta acttcacatt aaaaaatgaa atatttttta atttaaagct   1980 

tactctgtcc atttatccac aggaaagtgt tatttttaaa ggaaggttca tgtagagaaa   2040 

agcacacttg taggataagt gaaatggata ctacatcttt aaacagtatt tcattgcctg   2100 

tgtatggaaa aaccatttga agtgtacctg tgtacataac tctgtaaaaa cactgaaaaa   2160 

ttatactaac ttatttatgt taaaagattt tttttaatct agacaatata caagccaaag   2220 

tggcatgttt tgtgcatttg taaatgctgt gttgggtaga ataggttttc ccctcttttg   2280 

ttaaataata tggctatgct taaaaggttg catactgagc caagtataat tttttgtaat   2340 

gtgtgaaaaa gatgccaatt attgttacac attaagtaat caataaagaa aacttccata   2400 

gctaaaaaaa aaaaaaaaaa aa                                            2422 

 
           
             32  
             1181  
             DNA  
             human  
           
            32 

ggcacgaggc ccgggccccc caaagtcccg gccgggccga gggtcggcgg ccgccggcgg     60 

gccgggcccg cgcacagcgc ccgcatgtac aacatgatgg agacggagct gaagccgccg    120 

ggcccgcagc aaacttcggg gggcggcggc ggcaactcca ccgcggcggc ggccggcggc    180 

aaccagaaaa acagcccgga ccgcgtcaag cggcccatga atgccttcat ggtgtggtcc    240 

cgcgggcagc ggcgcaagat ggcccaggag aaccccaaga tgcacaactc ggagatcagc    300 

aagcgcctgg gcgccgagtg gaaacttttg tcggagacgg agaagcggcc gttcatcgac    360 

gaggctaagc ggctgcgagc gctgcacatg aaggagcacc cggattataa ataccggccc    420 

cggcggaaaa ccaagacgct catgaagaag gataagtaca cgctgcccgg cgggctgctg    480 

gcccccggcg gcaatagcat ggcgagcggg gtcggggtgg gcgccggcct gggcgcgggc    540 

gtgaaccagc gcatggacag ttacgcgcac atgaacggct ggagcaacgg cagctacagc    600 

atgatgcagg accagctggg ctacccgcag cacccgggcc tcaatgcgca cggcgcagcg    660 

cagatgcagc ccatgcaccg ctacgacgtg agcgccctgc agtacaactc catgaccagc    720 

tcgcagacct acatgaacgg ctcgcccacc tacagcatgt cctactcgca gcagggcacc    780 

cctggcatgg ctcttggctc catgggttcg gtggtcaagt ccgaggccag ctccagcccc    840 

cctgtggtta cctcttcctc ccactccagg gcgccctgcc aggccgggga cctccgggac    900 

atgatcagca tgtatctccc cggcgccgag gtgccggaac ccgccgcccc cagcagactt    960 

cacatgtccc agcactacca gagcggcccg gtgcccggca cggccattaa cggcacactg   1020 

cccctctcac acatgtgagg gccggacagc gaactggagg ggggagaaat tttcaaagaa   1080 

aaacgaggga aatgggaggg gtgcaaaaga ggagagtaag aaacagcatg gagaaaaccc   1140 

ggtacgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1181 

 
           
             33  
             1305  
             DNA  
             human  
           
            33 

ggggccccgc gccggcccgc gccctgccca gtgcggcctc cttccacccg ccgctgcctg     60 

gcccgcgccg tccggccgag ctgcccggcg ggctggtccc cgcgcccgag ccgcccggcc    120 

gggaccccga acaaggccga gatgacttcc aaggaggacg gcaaggcggc gccgggggag    180 

gagcggcgcc gcagcccgct ggaccacctg cctccgcctg ccaactccaa caagccagac    240 

gccgttcagc atcgaggaca tcctcaacaa gccgtctgtg cggagaagtt actcgctgcg    300 

tggggcggcg cacctgctgg ccgccgcgga caagcacgcg cagggcggct tgccctggcg    360 

ggccgcgcgc tgctctcgaa gacctcgccg ctgtgcgcgc tggaggagct cgccagcaag    420 

acgtttaagg ggctggaggt cagcgttctg caggcagccg aaggccgcga cggtatgacc    480 

atctttgggc agcggcagac ccctaagaag cggcgaaagt cgcgcacggc cttcaccaac    540 

caccagatct atgaattgga aaagcgcttt ctataccaga agtacctgtc ccccgccgat    600 

cgcgaccaaa tcgcgcagca gctgggcctc accaacgcgc aagtcatcac ctggttccag    660 

aatcggcgcg ctaagctcaa gcgggaactg gaggagatga aggccgacgt ggagtccccc    720 

aagaaactgg gccccagcgg gcagatggac atcgtggcgc tggccgaact cgagcagaac    780 

tcggaggcca cagccggcgg tggcggcggc tgcggcaggg ccaagtcgag gcccggctct    840 

ccggtcctcc ccccaggcgc cccgaaggcc cccgggcgct gcgccctgca gctctcgcct    900 

gcctctccgc tcacggacca gccggccagc agccaggact gctcggagga cgaggaagac    960 

gaagagatcg acgtggacga ttgagcggcg ccccgggtct tccgccgccc tgggctccta   1020 

gcgctcgaaa gcccaacgcc tcccggaccg gaccgccgag gggagctggg acctcctctg   1080 

ccactcccgc ctcctcccct gtccccggac tcggctcctg gcagccgcct cttccctctc   1140 

gaagcaataa acccaggctg gccggccggg ccggccgcca ccagcggcct ccgccgcccc   1200 

ggaagccctc gccgagcaat tctgtatggc ttctatataa atatttaaac ctatatagcg   1260 

ggttctcccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   1305 

 
           
             34  
             1926  
             DNA  
             human  
           
            34 

gctggagcat cccgctctgg tgccgctgca gccggcagag atggttgagc tcatgttccc     60 

gctgttgctc ctccttctgc ccttccttct gtatatggct gcgccccaaa tcaggaaaat    120 

gctgtccagt ggggtgtgta catcaactgt tcagcttcct gggaaagtag ttgtggtcac    180 

aggagctaat acaggtatcg ggaaggagac agccaaagag ctggctcaga gaggagctcg    240 

agtatattta gcttgccggg atgtggaaaa gggggaattg gtggccaaag agatccagac    300 

cacgacaggg aaccagcagg tgttggtgcg gaaactggac ctgtctgata ctaagtctat    360 

tcgagctttt gctaagggct tcttagctga ggaaaagcac ctccacgttt tgatcaacaa    420 

tgcaggagtg atgatgtgtc cgtactcgaa gacagcagat ggctttgaga tgcacatagg    480 

agtcaaccac ttgggtcact tcctcctaac ccatctgctg ctagagaaac taaaggaatc    540 

agccccatca aggatagtaa atgtgtcttc cctcgcacat cacctgggaa ggatccactt    600 

ccataacctg cagggcgaga aattctacaa tgcaggcctg gcctactgtc acagcaagct    660 

agccaacatc ctcttcaccc aggaactggc ccggagacta aaaggctctg gcgttacgac    720 

gtattctgta caccctggca cagtccaatc tgaactggtt cggcactcat ctttcatgag    780 

atggatgtgg tggcttttct cctttttcat caagactcct cagcagggag cccagaccag    840 

cctgcactgt gccttaacag aaggtcttga gattctaagt gggaatcatt tcagtgactg    900 

tcatgtggca tgggtctctg cccaagctcg taatgagact atagcaaggc ggctgtggga    960 

cgtcagttgt gacctgctgg gcctcccaat agactaacag gcagtgcagt tggacccaag   1020 

agaagactgc agcagactac acagtacttc ttgtcaaaat gattctcctt caaggttttc   1080 

aaaaccttta gcacaaagag agcaaaacct tccagccttg cctgcttggt gtccagttaa   1140 

aactcagtgt actgccagat tcgtctaaat gtctgtcatg tccagattta ctttgcttct   1200 

gttactgcca gagttactag agatatcata ataggataag aagaccctca tatgacctgc   1260 

acagctcatt ttccttctga aagaaactac tacctaggag aatctaagct atagcaggga   1320 

tgatttatgc aaatttgaac tagcttcttt gttcacaatt cagttcctcc caaccaacca   1380 

gtcttcactt caagagggcc acactgcaac ctcagcttaa catgaataac aaagactggc   1440 

tcaggagcag ggcttgccca ggcatggtgg atcaccggag tcagtagttc aagaccagcc   1500 

tggccaacat ggtgaaaccc cacctctact aaaaattgtg tatatctttg tgtgtcttcc   1560 

tgtttatgtg tgccaaggga gtattttcac aaagttcaaa acagccacaa taatcagaga   1620 

tggagcaaac cagtgccatc cagtctttat gcaaatgaaa tgctgcaaag ggaagcagat   1680 

tctgtatatg ttggtaacta cccaccaaga gcacatgggt agcagggaag aagtaaaaaa   1740 

agagaaggag aatactggaa gataatgcac aaaatgaagg gactagttaa ggattaacta   1800 

gccctttaag gattaactag ttaaggatta atagcaaaag acattaaata tgctaacata   1860 

gctatggagg aattgagggc aagcacccag gactgatgag gtcttaacaa aaaccagtgt   1920 

ggcaaa                                                              1926 

 
           
             35  
             1195  
             DNA  
             human  
           
            35 

ccgagactca cggtcaagct aaggcgaaga gtgggtggct gaagccatac tattttatag     60 

aattaatgga aagcagaaaa gacatcacaa accaagaaga actttggaaa atgaagccta    120 

ggagaaattt agaagaagac gattatttgc ataaggacac gggagagacc agcatgctaa    180 

aaagacctgt gcttttgcat ttgcaccaaa cagcccatgc tgatgaattt gactgccctt    240 

cagaacttca gcacacacag gaactctttc cacagtggca cttgccaatt aaaatagctg    300 

ctattatagc atctctgact tttctttaca ctcttctgag ggaagtaatt caccctttag    360 

caacttccca tcaacaatat ttttataaaa ttccaatcct ggtcatcaac aaagtcttgc    420 

caatggtttc catcactctc ttggcattgg tttacctgcc aggtgtgata gcagcaattg    480 

tccaacttca taatggaacc aagtataaga agtttccaca ttggttggat aagtggatgt    540 

taacaagaaa gcagtttggg cttctcagtt tcttttttgc tgtactgcat gcaatttata    600 

gtctgtctta cccaatgagg cgatcctaca gatacaagtt gctaaactgg gcatatcaac    660 

aggtccaaca aaataaagaa gatgcctgga ttgagcatga tgtttggaga atggagattt    720 

atgtgtctct gggaattgtg ggattggcaa tactggctct gttggctgtg acatctattc    780 

catctgtgag tgactctttg acatggagag aatttcacta tattcagagc aagctaggaa    840 

ttgtttccct tctactgggc acaatacacg cattgatttt tgcctggaat aagtggatag    900 

atataaaaca atttgtatgg tatacacctc caacttttat gatagctgtt ttccttccaa    960 

ttgttgtcct gatatttaaa agcatactat tcctgccatg cttgaggaag aagatactga   1020 

agattagaca tggttgggaa gacgtcacca aaattaacaa aactgagata tgttcccagt   1080 

tgtagaatta ctgtttacac acatttttgt tcaatattga tatattttat caccaacatt   1140 

tcaagtttgt atttgttaat aaaatgatta ttcaaggaaa aaaaaaaaaa aaaaa        1195 

 
           
             36  
             3414  
             DNA  
             human  
           
            36 

gcttacacag tatggccggc gacattagct agcgctcgct ctactctctc taacgggaaa     60 

gcagcggaat acaagagact gaactgtatc tgcctctatt tccaaaagac tcacgttcaa    120 

ctttcgctca cacaaagccg ggaaaatttt attagtcctt tttttaaaaa aagttaatat    180 

aaaattatag caaaaaaaaa aaggaacctg aactttagta acacagctgg aacaatcgca    240 

gcggcggcgg cagcggcggg agaagaggtt taatttagtt gattttctgt ggttgttggt    300 

tgttcgctag tctcacggtg atggaagctg cacatttttt cgaagggacc gagaagctgc    360 

tggaggtttg gttctcccgg cagcagcccg acgcaaacca aggatctggg gatcttcgca    420 

ctatcccaag atctgagtgg gacatacttt tgaaggatgt gcaatgttca atcataagtg    480 

tgacaaaaac tgacaagcag gaagcttatg tactcagtga gagtagcatg tttgtctcca    540 

agagacgttt cattttgaag acatgtggta ccaccctctt gctgaaagca ctggttcccc    600 

tgttgaagct tgctagggat tacagtgggt ttgactcaat tcaaagcttc ttttattctc    660 

gtaagaattt catgaagcct tctcaccaag ggtacccaca ccggaatttc caggaagaaa    720 

tagagtttct taatgcaatt ttcccaaatg gagcaggata ttgtatggga cgtatgaatt    780 

ctgactgttg gtacttatat actctggatt tcccagagag tcgggtaatc agtcagccag    840 

atcaaacctt ggaaattctg atgagtgagc ttgacccagc agttatggac cagttctaca    900 

tgaaagatgg tgttactgca aaggatgtca ctcgtgagag tggaattcgt gacctgatac    960 

caggttctgt cattgatgcc acaatgttca atccttgtgg gtattcgatg aatggaatga   1020 

aatcggatgg aacttattgg actattcaca tcactccaga accagaattt tcttatgtta   1080 

gctttgaaac aaacttaagt cagacctcct atgatgacct gatcaggaaa gttgtagaag   1140 

tcttcaagcc aggaaaattt gtgaccacct tgtttgttaa tcagagttct aaatgtcgca   1200 

cagtgcttgc ttcgccccag aagattgaag gttttaagcg tcttgattgc cagagtgcta   1260 

tgttcaatga ttacaatttt gtttttacca gttttgctaa gaagcagcaa caacagcaga   1320 

gttgattaag aaaaatgaag aaaaaacgca aaaagagaac acatgtagaa ggtggtggat   1380 

gctttctaga tgtcgatgct gggggcagtg ctttccataa ccaccactgt gtagttgcag   1440 

aaagccctag atgtaatgat agtgtaatca ttttgaattg tatgcattat tatatcaagg   1500 

agttagatat cttgcatgaa tgctctcttc tgtgtttagg tattctctgc cactcttgct   1560 

gtgaaattga agtggatgta gaaaaaacct tttactatat gaaactttac aacacttgtg   1620 

aaagcaactc aatttggttt atgcacagtg taatatttct ccaagtatca tccaaaattc   1680 

cccacagaca aggctttcgt cctcattagg tgttggcctc agcctaaccc tctaggactg   1740 

ttctattaaa ttgctgccag aattttacat ccagttacct ccactttcta gaacatattc   1800 

tttactaatg ttattgaaac caatttctac ttcatactga tgtttttgga aacagcaatt   1860 

aaagtttttc ttccatagtt gagtccttag aaaatgattc cagttactca ttttgcatat   1920 

tgctatttaa cattattgga ccctgcattt atagtccttt gatttcttcc ctctccctgg   1980 

tgtctccccc aagaccccaa ataaagcaat accctgttaa cactgtgggt ttatatacta   2040 

attctatacc ccagatgggg aattaggggg gagatggtcc ctgggcttaa tattctttaa   2100 

agggcatggg aatttagcct ctcttttatt gtaatgtgct cttttggaaa atagttggtt   2160 

agcagggaga ccagagttgt agattgagat tgggtgtact ggctgttctg tggaaaacat   2220 

acattctgtg ttcctcgaat aagtgaaatt gagcttctaa tgagatgcac ccctttacta   2280 

acttgatgat gatataaaat tcatttttat ttagttaatt accagagaga tttagcataa   2340 

ttttgcttct ggattcagta aatcaagtca gcttggatca ttcaccttaa cttttccttt   2400 

agcagccctt tccactagtt tcccattaag tagtgttcta taaactttga tccaaagcag   2460 

aatcaatgtc ttttccatct cgtgacttaa agttctgtga ctgtgatgca tgtgagtgtt   2520 

ccgacttcat ctgttcctct taactacggt gtttccctta ccgatcggca ttcataggat   2580 

gaaatgaatg actgtcccag aatgagaatt tgtccagatt attcagataa acatcataaa   2640 

gagaataaca ttataaataa gtagaatatg aataaataga ataataaaat tccaaaatac   2700 

tcaatgggaa atgactagta atataggctt tcaagagttg gtacctttac gtatatttgc   2760 

agattctctg ggattttaag gaactgagaa aacagaaaag ttgactaaat tttatatttc   2820 

ttgtcctcta aatattttga taatttctgg attgatgcag tgatgttttt cgttccttgt   2880 

atttataaat gaaaaccttt ttttggtgtt tctaaaccta aaatctactt ggtttgaaat   2940 

caagtggttg gaacactgtt tgacttttat ttgaagcatg ttgttgattg aaaatttcat   3000 

tgaggaagtt ttcaatcagt gtgatcagtt tgattctgta atgagcacag cacctaatat   3060 

tttgaggagc tctgttttga ggaccaatgc ttaaggtgga ccttgttgct aaacaatatc   3120 

ccaatagatt tgttgacttg aggtctggtt tggttttgtt tttgttttgt tttggttttg   3180 

ttttgtttcc caatagaatt aagaattcta atgttgaaaa actgtataaa tttttatggg   3240 

acaaagccta gaaaagagaa atgtagtttg aatcataatc taaatcatcg tatgatagga   3300 

aggaaaagtt ttggtgccat aatttctcct ttcactggtg ttggacttaa atcagttgaa   3360 

atgtatttct gtaccacaat ttacgcttca ataaaagttt aattgtctag tgag         3414 

 
           
             37  
             3287  
             DNA  
             human  
           
            37 

agactgaggc ggaggcagcc ccgcgccgcg ccggacccga gcatatttca ttttctgtca     60 

ttggactttg agccattaga accatgagca actacagtgt gtcactggtt ggcccagctc    120 

cttggggttt ccggctgcag ggcggtaagg atttcaacat gcctctgaca atctctagtc    180 

taaaagatgg cggcaaggca gcccaggcaa atgtaagaat aggcgatgtg gttctcagca    240 

ttgatggaat aaatgcacaa ggaatgactc atcttgaagc ccagaataag attaagggtt    300 

gtacaggctc tttgaatatg actctgcaaa gagcatctgc tgcacccaag cctgagccgg    360 

ttcctgttca aaagggagaa cctaaagaag tagttaaacc tgtgcccatt acatctcctg    420 

ctgtgtccaa agtcacttcc acaaacaaca tggcctacaa taaggcacca cggccttttg    480 

gttctgtgtc ttcaccaaaa gtcacatcca tcccatcacc atcgtctgcc ttcaccccag    540 

cccatgcgac cacctcatca catgcttccc cttcacccgt ggctgccgtc actcctcccc    600 

tgttcgctgc atctggactg catgctaatg ccaatcttag tgctgaccag tctccatctg    660 

cactgagcgc tggtaaaact gcagttaatg tcccacggca gcccacagtc accagcgtgt    720 

gttccgagac ttctcaggag ctagcagagg gacagagaag aggatcccag ggtgacagta    780 

aacagcaaaa tggcccacca agaaaacaca ttgtggagcg ctatacagag ttttatcatg    840 

tacccactca cagtgatgcc agcaagaaga gactgattga ggatactgaa gactggcgtc    900 

caagaactgg aacaactcag tctcgctctt tccgaatcct tgcccagatc actgggactg    960 

aacatttgaa agaatctgaa gccgataata caaagaaggc aaataactct caggagcctt   1020 

ctccgcagtt ggcttccttg gtagcttcca cacggagcat gcccgagagc ctggacagcc   1080 

caacctctgg cagaccaggg gttaccagcc tcacaactgc agctgccttc aagcctgtag   1140 

gatccactgg cgtcatcaag tcaccaagct ggcaacggcc aaaccaagga gtaccttcca   1200 

ctggaagaat ctcaaacagc gctacttact caggatcagt ggcaccagcc aactcagctt   1260 

tgggacaaac ccagccaagt gaccaggaca ctttagtgca aagagctgag cacattccag   1320 

cagggaaacg aactccgatg tgcgcccatt gtaaccaggt catcagagga ccattcttag   1380 

tggcactggg gaaatcttgg cacccagaag aattcaactg cgctcactgc aaaaatacaa   1440 

tggcctacat tggatttgta gaggagaaag gagccctgta ttgtgagctg tgctatgaga   1500 

aattctttgc ccctgaatgt ggtcgatgcc aaaggaagat ccttggagaa gtcatcaatg   1560 

cgttgaaaca aacttggcat gtttcctgtt ttgtgtgtgt agcctgtgga aagcccattc   1620 

ggaacaatgt ttttcacttg gaggatggtg aaccctactg tgagactgat tattatgccc   1680 

tctttggtac tatatgccat ggatgtgaat ttcccataga agctggtgac atgttcctgg   1740 

aagctctggg ctacacctgg catgacactt gctttgtatg ctcagtgtgt tgtgaaagtt   1800 

tggaaggtca gacctttttc tccaagaagg acaagcccct gtgtaagaaa catgctcatt   1860 

ctgtgaattt ttgaaagtca acagttcagg agaagagaag gaatttgaag agaaaaagga   1920 

aaattaaaat tactaattaa tttttagatt caatatttat atggagtttt gaaaaataat   1980 

agtggccctg aaggaataaa ttccagcttt aaaaaccaag tctgaggaaa tatttggctt   2040 

cataaagtaa agagacggtt tggcatttat tattactttt tcctgtattt tatgcccata   2100 

aaataagctt tataaaaacc aatttcctga tggactatta aattcatctt agaataaatt   2160 

agtgaagaat ttaattttag aataaataat ccaatctgaa ataattatac cttctttcct   2220 

tgttaggtag ttatgagtaa atctgcaaaa ggcaatgaaa atgccttaaa ttttatcaat   2280 

aacagaatta ttgtatttaa aaaaaaacta atacttatct ttaaaatagt aaataggatt   2340 

ttaaacagag aattttatca gtaataggtg tcagttttta aaaaattgct tgtaggctga   2400 

gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtggg tggaccacat   2460 

gaggtcagga gtttgagatc agcctggcca acatggtgaa accccatctc tactaaaaat   2520 

acaaaaatta gccggacgca gtggcacgcg cctgtaatcc cagctactca agaggctgag   2580 

gcacgagaat cacttgaacc cgggagggag aggttgcagt gagccaagat cgtaccactg   2640 

cactccagcc tgggtgacag agtgagactc cgtctccaaa aaaaaacttt gcttgtatat   2700 

tatttttgcc ttacagtgga tcattctagt aggaaaggac aataagattt tttatcaaaa   2760 

tgtgtcatgc cagtaagaga tgttatattc ttttcttatt tcttccccac ccaaaaataa   2820 

gctaccatat agcttataag tctcaaattt ttgcctttta ctaaaatgtg attgtttctg   2880 

ttcattgtgt atgcttcatc acctatatta ggcaaattcc attttttccc ttgcgctaag   2940 

gtaaagattt aattaaataa ttttggcctc tcatagtttt ctctctcttt aaagagaata   3000 

aatagagggc caggtgtggt ggctcacgcc tgtgatccca gcactttggg aggccaagac   3060 

gggcggatca tgaggtcaag agatcaagat catcctggcc aacatggtga aaccctgtct   3120 

ctactaaaaa tacaaaaatg agctgggcat ggtggggcgt gcctgtagtc ccatgtactt   3180 

gggaggctga ggcaggaaaa ttcttgaacc caggagacgg aagttgcagt gagctgagat   3240 

cacaccactg cactccagcc tggtgacaga gcaagactcc ggctctt                 3287 

 
           
             38  
             1254  
             DNA  
             human  
           
            38 

atggcagtgg agaccacggt ccacactcac ctctctgcgt ctccaccgca gggctctccc     60 

tacgaccaca cacccggcat ggcgggctcc ttggggtacc atccttacgc ggcgcccctg    120 

ggatcgtacc cttacgggga cccagcgtac cggaagaacg ccacaaggga cgccacggct    180 

accctcaagg cctggctcaa cgagcaccgc aagaacccct accccaccaa gggcgagaag    240 

atcatgctgg ccatcatcac caagatgacc ctcacccagg tgtccacctg gttcgccaac    300 

gcgcgccggc gcctcaagaa agagaataaa atgacgtgga cgccgcggaa ccgcagcgag    360 

gacgaggaag aggaggagaa cattgacctg gagaagaacg acgaggacga gccccagaag    420 

cccgaggaca agggcgaccc cgagggcccc gaagcaggag gagctgagca gaaggcggct    480 

tcgggctgcg aacggcttca gggaccaccc acccctgcag gcaaggagac ggagggcagc    540 

ctcagcgact cggattttaa ggagccgccc tcggagggcc gcctcgacgc gctgcagggc    600 

cccccccgca ccggcgggcc ctccccggct gggccagcgg cggcgcggct ggcggaggac    660 

ccggcccctc actaccccgc cggagcgccg gcgcccggcc cgcatccagc cgcgggcgag    720 

gtgcctccgg gtcccggcgg gccctcggtt atccattcgc cgcctccgcc gccgcctcct    780 

gcggtgctcg ccaagcccaa actgtggtct ttggcagaga tcgccacatt gtcggacaag    840 

gtcaaggacg ggggcggcgg gaacgagggc tctccatgcc caccgtgtcc cgggcccata    900 

gccgggcaag ccctaggagg cagccgggcg tcgccggccc cggcgccgtc acgctcgccc    960 

tcggcgcagt gtccttttcc aggcgggacg gtgctgtccc ggcctctcta ctacaccgcg   1020 

cccttctatc ccggctacac gaactatggc tccttcggac accttcatgg ccacccgggg   1080 

cccgggccag gccccacaac cggtccgggg tctcatttca atggattaaa ccagaccgtg   1140 

ttgaaccgag cggacgcttt ggctaaagac ccgaaaatgt tgcggagcca gtctcagcta   1200 

gacctgtgca aagactctcc ctatgaattg aagaaaggta tgtccgacat ttaa         1254 

 
           
             39  
             2560  
             DNA  
             human  
           
            39 

gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata     60 

accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc    120 

caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct    180 

tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc    240 

ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg    300 

ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc    360 

atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca    420 

ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg    480 

ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca    540 

gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt    600 

gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca    660 

gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg    720 

caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc    780 

catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa    840 

ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct    900 

gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt    960 

cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct   1020 

ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat   1080 

caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc   1140 

cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc   1200 

ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta   1260 

tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat   1320 

ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag   1380 

cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac   1440 

agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg   1500 

cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa   1560 

tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca   1620 

gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa   1680 

caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg   1740 

tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat   1800 

ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc   1860 

aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct   1920 

gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac   1980 

atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca   2040 

gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt   2100 

aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc   2160 

aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt   2220 

aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac   2280 

agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca   2340 

tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag   2400 

cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg   2460 

atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag   2520 

ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc                         2560 

 
           
             40  
             2560  
             DNA  
             human  
           
            40 

gaattccggc cagaagaaat ctggcctcgg aacacgccat tctccgcgcc gcttccaata     60 

accactaaca tccctaacga gcatccgagc cgagggctct gctcggaaat cgtcctggcc    120 

caactcggcc cttcgagctc tcgaagatta ccgcatctat tttttttttc ttttttttct    180 

tttcctagcg cagataaagt gagcccggaa agggaaggag ggggcgggga caccattgcc    240 

ctgaaagaat aaataagtaa ataaacaaac tggctcctcg ccgcagctgg acgcggtcgg    300 

ttgagtccag gttgggtcgg acctgaaccc ctaaaagcgg aaccgcctcc cgccctcgcc    360 

atcccggagc tgagtcgccg gcggcggtgg ctgctgccag acccggagtt tcctctttca    420 

ctggatggag ctgaactttg ggcggccaga gcagcacagc tgtccgggga tcgctgcacg    480 

ctgagctccc tcggcaagac ccagcggcgg ctcgggattt ttttgggggg gcggggacca    540 

gccccgcgcc ggcaccatgt tcctggcgac cctgtacttc gcgctgccgc tcttggactt    600 

gctcctgtcg gccgaagtga gcggcggaga ccgcctggat tgcgtgaaag ccagtgatca    660 

gtgcctgaag gagcagagct gcagcaccaa gtaccgcacg ctaaggcagt gcgtggcggg    720 

caaggagacc aacttcagcc tggcatccgg cctggaggcc aaggatgagt gccgcagcgc    780 

catggaggcc ctgaagcaga agtcgctcta caactgccgc tgcaagcggg gtatgaagaa    840 

ggagaagaac tgcctgcgca tttactggag catgtaccag agcctgcagg gaaatgatct    900 

gctggaggat tccccatatg aaccagttaa cagcagattg tcagatatat tccgggtggt    960 

cccattcata tcagatgttt ttcagcaagt ggagcacatt cccaaaggga acaactgcct   1020 

ggatgcagcg aaggcctgca acctcgacga catttgcaag aagtacaggt cggcgtacat   1080 

caccccgtgc accaccagcg tgtccaacga tgtctgcaac cgccgcaagt gccacaaggc   1140 

cctccggcag ttctttgaca aggtcccggc caagcacagc tacggaatgc tcttctgctc   1200 

ctgccgggac atcgcctgca cagagcggag gcgacagacc atcgtgcctg tgtgctccta   1260 

tgaagagagg gagaagccca actgtttgaa tttgcaggac tcctgcaaga cgaattacat   1320 

ctgcagatct cgccttgcgg atttttttac caactgccag ccagagtcaa ggtctgtcag   1380 

cagctgtcta aaggaaaact acgctgactg cctcctcgcc tactcggggc ttattggcac   1440 

agtcatgacc cccaactaca tagactccag tagcctcagt gtggccccat ggtgtgactg   1500 

cagcaacagt gggaacgacc tagaagagtg cttgaaattt ttgaatttct tcaaggacaa   1560 

tacatgtctt aaaaatgcaa ttcaagcctt tggcaatggc tccgatgtga ccgtgtggca   1620 

gccagccttc ccagtacaga ccaccactgc cactaccacc actgccctcc gggttaagaa   1680 

caagcccctg gggccagcag ggtctgagaa tgaaattccc actcatgttt tgccaccgtg   1740 

tgcaaattta caggcacaga agctgaaatc caatgtgtcg ggcaatacac acctctgtat   1800 

ttccaatggt aattatgaaa aagaaggtct cggtgcttcc agccacataa ccacaaaatc   1860 

aatggctgct cctccaagct gtggtctgag cccactgctg gtcctggtgg taaccgctct   1920 

gtccacccta ttatctttaa cagaaacatc atagctgcat taaaaaaata caatatggac   1980 

atgtaaaaag acaaaaacca agttatctgt ttcctgttct cttgtatagc tgaaattcca   2040 

gtttaggagc tcagttgaga aacagttcca ttcaactgga acattttttt ttttcctttt   2100 

aagaaagctt cttgtgatcc ttcggggctt ctgtgaaaaa cctgatgcag tgctccatcc   2160 

aaactcagaa ggctttggga tatgctgtat tttaaaggga cagtttgtaa cttgggctgt   2220 

aaagcaaact ggggctgtgt tttcgatgat gatgatcatc atgatcatga tgattttaac   2280 

agttttactt ctggcctttc ctagctagag aaggagttaa tatttctaag gtaactccca   2340 

tatctccttt aatgacattg atttctaatg atataaattt cagcctacat tgatgccaag   2400 

cttttttgcc acaaagaaga ttcttaccaa gagtgggctt tgtggaaaca gctggtactg   2460 

atgttcacct ttatatatgt actagcattt tccacgctga tgtttatgta ctgtaaacag   2520 

ttctgcactc ttgtacaaaa gaaaaaacca cccggaattc                         2560 

 
           
             41  
             2439  
             DNA  
             human  
           
            41 

cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac     60 

cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc    120 

gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct    180 

gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg    240 

cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc    300 

gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg    360 

cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa    420 

cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga    480 

ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa    540 

ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt    600 

ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg    660 

cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg    720 

ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc    780 

gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct    840 

agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg    900 

cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg    960 

cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg   1020 

gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg   1080 

gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga   1140 

cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa   1200 

ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca   1260 

gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag   1320 

cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc   1380 

taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga   1440 

cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca   1500 

ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa   1560 

ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag   1620 

ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt   1680 

ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt   1740 

gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac   1800 

ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt   1860 

catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga   1920 

gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa   1980 

cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg   2040 

aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt   2100 

gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt   2160 

cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat   2220 

catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca   2280 

tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc   2340 

gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag   2400 

aagggctcag agaggacaaa ataaagtgtg tgtgcaggg                          2439 

 
           
             42  
             2439  
             DNA  
             human  
           
            42 

cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac     60 

cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc    120 

gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct    180 

gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg    240 

cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc    300 

gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg    360 

cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa    420 

cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga    480 

ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa    540 

ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt    600 

ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg    660 

cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg    720 

ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc    780 

gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct    840 

agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg    900 

cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg    960 

cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg   1020 

gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg   1080 

gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga   1140 

cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa   1200 

ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca   1260 

gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag   1320 

cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc   1380 

taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga   1440 

cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca   1500 

ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa   1560 

ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag   1620 

ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt   1680 

ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt   1740 

gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac   1800 

ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt   1860 

catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga   1920 

gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa   1980 

cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg   2040 

aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt   2100 

gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt   2160 

cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat   2220 

catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca   2280 

tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc   2340 

gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag   2400 

aagggctcag agaggacaaa ataaagtgtg tgtgcaggg                          2439 

 
           
             43  
             1385  
             DNA  
             human  
           
            43 

ctccagccat tggtgtctgt gtcattacta atagagtctt gtaaacactc gttaatcacg     60 

gaagccgccg gcctggggct ccgcacgcca gcctgtgcgg gtcttccccg cctctgcagc    120 

ctagtgggaa ggaggtggga ggaaagaagg aagaaaggga gggagggagg aggcaggcca    180 

gagggaggga ccgcctcgga ggcagaagag ccgcgaggag ccagcggagc accgcgggct    240 

ggggcgcagc cacccgccgc tcctcgagtc ccctcgcccc tttcccttcg tgccccccgg    300 

cagcctccag cgtcggtccc caggcagcat ggtgaggtct gctcccggtc cctcgccacc    360 

atgtacgtga gctacctcct ggacaaggac gtgagcatgt accctagctc cgtgcgccac    420 

tctggcggcc tcaacctggc gccgcagaac ttcgtcagcc ccccgcagta cccggactac    480 

ggcggttacc acgtggcggc cgcagctgca gcggcagcga acttggacag cgcgcagtcc    540 

ccggggccat cctggccggc agcgtatggc gccccactcc gggaggactg gaatggctac    600 

gcgcccggag gcgccgcggc cgccgccaac gccgtggctc acggcctcaa cggtggctcc    660 

ccggccgcag ccatgggcta cagcagcccc gcagactacc atccgcacca ccacccgcat    720 

caccacccgc accacccggc cgcggcgcct tcctgcgctt ctgggctgct gcaaacgctc    780 

aaccccggcc ctcctgggcc cgccgccacc gctgccgccg agcagctgtc tcccggcggc    840 

cagcggcgga acctgtgcga gtggatgcgg aagccggcgc agcagtccct cggcagccaa    900 

gtgaaaacca ggacgaaaga caaatatcga gtggtgtaca cggaccacca gcggctggag    960 

ctggagaagg agtttcacta cagtcgctac atcaccatcc ggaggaaagc cgagctagcc   1020 

gccacgctgg ggctctctga gaggcaggtt aaaatctggt ttcagaaccg cagagcaaag   1080 

gagaggaaaa tcaacaagaa gaagttgcag cagcaacagc agcagcagcc accacagccg   1140 

cctccgccgc caccacagcc tccccagcct cagccaggtc ctctgagaag tgtcccagag   1200 

cccttgagtc cggtgtcttc cctgcaagcc tcagtgtctg gctctgtccc tggggttctg   1260 

gggccaactg ggggggtgct aaaccccacc gtcacccagt gacccaccgg ggttctgcag   1320 

cggcagagca attccaggct gagccatgag gagcgtggac tctgctagac tcctcaggag   1380 

agacc                                                               1385 

 
           
             44  
             4098  
             DNA  
             human  
           
            44 

ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcgggga gaaagactct     60 

ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggc gtgctgccgg    120 

agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggag ccgcggccca    180 

cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccg tcagccgctg    240 

cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtg ccggaggatg    300 

ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcg gcggccgggg    360 

acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccag gtggacctgg    420 

tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcg gcagcggcgg    480 

cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagcc agcggcgaga    540 

gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaac ttcgtggacc    600 

cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtc ggagtcgacg    660 

ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggc agcagcctgc    720 

actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgat acccacacca    780 

acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgccc aggatcgatc    840 

actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagc ctggcggagc    900 

tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggg gaagaaagta    960 

ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtc gtgaagtttg   1020 

gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtg atgcttttca   1080 

ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtcctt gtaataatga   1140 

tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagca actaatggat   1200 

ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggcca gaatttggtg   1260 

gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatg tatgtggttg   1320 

gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatg atagatgaaa   1380 

tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggt atctcagtag   1440 

ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatccta cttcttgcta   1500 

ttggtgattt cgtcatagga acatttatcc cactggagag caagaagcca aaagggtttt   1560 

ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcga gaggaagaga   1620 

ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctg gctggagcaa   1680 

atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaaca ctcctagcca   1740 

ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc   1800 

gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaac tgtacttctg   1860 

cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgt tcctatggcc   1920 

taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccacta atttctgcag   1980 

gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgct cccaaaatat   2040 

ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgct aaaggttatg   2100 

ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgca cttggattca   2160 

tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttc cttgcatcat   2220 

atgcattgat caatttttca gtattccatg catcacttgc aaaatctcca ggatggcgtc   2280 

ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctt tgttgcatag   2340 

taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtc cttgggctgt   2400 

atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctaca caagccctga   2460 

cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagac cacgtgaaaa   2520 

actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtcca gctttacttc   2580 

atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccat gtacatatgg   2640 

gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatat cagcgatggc   2700 

ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgac ttgagagaag   2760 

gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaac acacttgtcc   2820 

ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatg tatataaact   2880 

tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgccta aaagaaggtc   2940 

tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagag aaatctcctg   3000 

gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgattta gatacttcca   3060 

aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggc aagactgcaa   3120 

ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaat gtagctgacc   3180 

aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaat actattgatg   3240 

tctggtggct ttttgatgat ggaggtttga ccttattgat accttacctt ctgacgacca   3300 

agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagata aacagaatag   3360 

accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagac ttttctgata   3420 

tcatggttct aggagatatc aataccaaac caaagaaaga aaatattata gcttttgagg   3480 

aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatatt gcagataaaa   3540 

tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttat aagaccaaga   3600 

cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcaca gctaatatta   3660 

ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctc tacatggcat   3720 

ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtggg aatcatcaga   3780 

gtgtccttac cttctattca taaatgttct atacagtgga cagccctcca gaatggtact   3840 

tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcac aatggcgaat   3900 

ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagct tgctccattg   3960 

ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatctta atggtgattc   4020 

ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaa tagcaataaa   4080 

agcgtgttaa ctttttgg                                                 4098 

 
           
             45  
             4098  
             DNA  
             human  
           
            45 

ggtggcctct gtggccgtcc aggctagcgg cggcccgcag gcggcgggga gaaagactct     60 

ctcacctggt cttgcggctg tggccaccgc cggccagggg tgtggagggc gtgctgccgg    120 

agacgtccgc cgggctctgc agttccgccg ggggtcgggc agctatggag ccgcggccca    180 

cggcgccctc ctccggcgcc ccgggactgg ccggggtcgg ggagacgccg tcagccgctg    240 

cgctggccgc agccagggtg gaactgcccg gcacggctgt gccctcggtg ccggaggatg    300 

ctgcgcccgc gagccgggac ggcggcgggg tccgcgatga gggccccgcg gcggccgggg    360 

acgggctggg cagacccttg gggcccaccc cgagccagag ccgtttccag gtggacctgg    420 

tttccgagaa cgccgggcgg gccgctgctg cggcggcggc ggcggcggcg gcagcggcgg    480 

cggctggtgc tggggcgggg gccaagcaga cccccgcgga cggggaagcc agcggcgaga    540 

gcgagccagc taaaggcagc gaggaagcca agggccgctt ccgcgtgaac ttcgtggacc    600 

cagctgcctc ctcgtcggct gaagacagcc tgtcagatgc tgccggggtc ggagtcgacg    660 

ggcccaacgt gagcttccag aacggcgggg acacggtgct gagcgagggc agcagcctgc    720 

actccggcgg cggcggcggc agtgggcacc accagcacta ctattatgat acccacacca    780 

acacctacta cctgcgcacc ttcggccaca acaccatgga cgctgtgccc aggatcgatc    840 

actaccggca cacagccgcg cagctgggcg agaagctgct ccggcctagc ctggcggagc    900 

tccacgacga gctggaaaag gaaccttttg aggatggctt tgcaaatggg gaagaaagta    960 

ctccaaccag agatgctgtg gtcacgtata ctgcagaaag taaaggagtc gtgaagtttg   1020 

gctggatcaa gggtgtatta gtacgttgta tgttaaacat ttggggtgtg atgcttttca   1080 

ttagattgtc atggattgtg ggtcaagctg gaataggtct atcagtcctt gtaataatga   1140 

tggccactgt tgtgacaact atcacaggat tgtctacttc agcaatagca actaatggat   1200 

ttgtaagagg aggaggagca tattatttaa tatctagaag tctagggcca gaatttggtg   1260 

gtgcaattgg tctaatcttc gcctttgcca acgctgttgc agttgctatg tatgtggttg   1320 

gatttgcaga aaccgtggtg gagttgctta aggaacattc catacttatg atagatgaaa   1380 

tcaatgatat ccgaattatt ggagccatta cagtcgtgat tcttttaggt atctcagtag   1440 

ctggaatgga gtgggaagca aaagctcaga ttgttctttt ggtgatccta cttcttgcta   1500 

ttggtgattt cgtcatagga acatttatcc cactggagag caagaagcca aaagggtttt   1560 

ttggttataa atctgaaata tttaatgaga actttgggcc cgattttcga gaggaagaga   1620 

ctttcttttc tgtatttgcc atcttttttc ctgctgcaac tggtattctg gctggagcaa   1680 

atatctcagg tgatcttgca gatcctcagt cagccatacc caaaggaaca ctcctagcca   1740 

ttttaattac tacattggtt tacgtaggaa ttgcagtatc tgtaggttct tgtgttgttc   1800 

gagatgccac tggaaacgtt aatgacacta tcgtaacaga gctaacaaac tgtacttctg   1860 

cagcctgcaa attaaacttt gatttttcat cttgtgaaag cagtccttgt tcctatggcc   1920 

taatgaacaa cttccaggta atgagtatgg tgtcaggatt tacaccacta atttctgcag   1980 

gtatattttc agccactctt tcttcagcat tagcatccct agtgagtgct cccaaaatat   2040 

ttcaggctct atgtaaggac aacatctacc cagctttcca gatgtttgct aaaggttatg   2100 

ggaaaaataa tgaacctctt cgtggctaca tcttaacatt cttaattgca cttggattca   2160 

tcttaattgc tgaactgaat gttattgcac caattatctc aaacttcttc cttgcatcat   2220 

atgcattgat caatttttca gtattccatg catcacttgc aaaatctcca ggatggcgtc   2280 

ctgcattcaa atactacaac atgtggatat cacttcttgg agcaattctt tgttgcatag   2340 

taatgttcgt cattaactgg tgggctgcat tgctaacata tgtgatagtc cttgggctgt   2400 

atatttatgt tacctacaaa aaaccagatg tgaattgggg atcctctaca caagccctga   2460 

cttacctgaa tgcactgcag cattcaattc gtctttctgg agtggaagac cacgtgaaaa   2520 

actttaggcc acagtgtctt gttatgacag gtgctccaaa ctcacgtcca gctttacttc   2580 

atcttgttca tgatttcaca aaaaatgttg gtttgatgat ctgtggccat gtacatatgg   2640 

gtcctcgaag acaagccatg aaagagatgt ccatcgatca agccaaatat cagcgatggc   2700 

ttattaagaa caaaatgaag gcattttatg ctccagtaca tgcagatgac ttgagagaag   2760 

gtgcacagta tttgatgcag gctgctggtc ttggtcgtat gaagccaaac acacttgtcc   2820 

ttggatttaa gaaagattgg ttgcaagcag atatgaggga tgtggatatg tatataaact   2880 

tatttcatga tgcttttgac atacaatatg gagtagtggt tattcgccta aaagaaggtc   2940 

tggatatatc tcatcttcaa ggacaagaag aattattgtc atcacaagag aaatctcctg   3000 

gcaccaagga tgtggtagta agtgtggaat atagtaaaaa gtccgattta gatacttcca   3060 

aaccactcag tgaaaaacca attacacaca aagttgagga agaggatggc aagactgcaa   3120 

ctcaaccact gttgaaaaaa gaatccaaag gccctattgt gcctttaaat gtagctgacc   3180 

aaaagcttct tgaagctagt acacagtttc agaaaaaaca aggaaagaat actattgatg   3240 

tctggtggct ttttgatgat ggaggtttga ccttattgat accttacctt ctgacgacca   3300 

agaaaaaatg gaaagactgt aagatcagag tattcattgg tggaaagata aacagaatag   3360 

accatgaccg gagagcgatg gctactttgc ttagcaagtt ccggatagac ttttctgata   3420 

tcatggttct aggagatatc aataccaaac caaagaaaga aaatattata gcttttgagg   3480 

aaatcattga gccatacaga cttcatgaag atgataaaga gcaagatatt gcagataaaa   3540 

tgaaagaaga tgaaccatgg cgaataacag ataatgagct tgaactttat aagaccaaga   3600 

cataccggca gatcaggtta aatgagttat taaaggaaca ttcaagcaca gctaatatta   3660 

ttgtcatgag tctcccagtt gcacgaaaag gtgctgtgtc tagtgctctc tacatggcat   3720 

ggttagaagc tctatctaag gacctaccac caatcctcct agttcgtggg aatcatcaga   3780 

gtgtccttac cttctattca taaatgttct atacagtgga cagccctcca gaatggtact   3840 

tcagtgccta gtgtagtaac ctgaaatctt caatgacaca ttaacatcac aatggcgaat   3900 

ggtgactttt ctttcacgat ttcattaatt tgaaagcaca caggaaagct tgctccattg   3960 

ataacgtgta tggagacttc ggttttagtc aattccatat ctcaatctta atggtgattc   4020 

ttctctgttg aactgaagtt tgtgagagta gttttccttt gctacttgaa tagcaataaa   4080 

agcgtgttaa ctttttgg                                                 4098 

 
           
             46  
             3311  
             DNA  
             human  
           
            46 

tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg     60 

gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa    120 

tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag    180 

agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata    240 

agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac    300 

cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca    360 

tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca    420 

ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg    480 

ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat    540 

ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa    600 

acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat    660 

gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc    720 

aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag    780 

ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg    840 

ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa    900 

gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc    960 

agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt   1020 

gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt   1080 

gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa   1140 

aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag   1200 

aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga   1260 

caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc   1320 

aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg   1380 

gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac   1440 

agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg   1500 

tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat   1560 

ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac   1620 

gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa   1680 

gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt   1740 

cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct   1800 

cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat   1860 

ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca   1920 

acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta   1980 

gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact   2040 

tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg   2100 

tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa   2160 

ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg   2220 

gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg   2280 

gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca   2340 

acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca   2400 

gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag   2460 

aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac   2520 

aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca   2580 

aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt   2640 

cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga   2700 

acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc   2760 

aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa   2820 

gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct   2880 

attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct   2940 

ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct   3000 

tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg   3060 

aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata   3120 

aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc   3180 

tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg   3240 

ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac   3300 

aactgggtaa a                                                        3311 

 
           
             47  
             3311  
             DNA  
             human  
           
            47 

tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg     60 

gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa    120 

tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag    180 

agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata    240 

agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac    300 

cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca    360 

tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca    420 

ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg    480 

ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat    540 

ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa    600 

acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat    660 

gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc    720 

aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag    780 

ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg    840 

ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa    900 

gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc    960 

agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt   1020 

gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt   1080 

gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa   1140 

aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag   1200 

aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga   1260 

caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc   1320 

aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg   1380 

gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac   1440 

agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg   1500 

tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat   1560 

ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac   1620 

gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa   1680 

gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt   1740 

cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct   1800 

cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat   1860 

ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca   1920 

acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta   1980 

gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact   2040 

tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg   2100 

tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa   2160 

ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg   2220 

gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg   2280 

gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca   2340 

acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca   2400 

gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag   2460 

aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac   2520 

aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca   2580 

aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt   2640 

cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga   2700 

acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc   2760 

aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa   2820 

gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct   2880 

attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct   2940 

ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct   3000 

tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg   3060 

aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata   3120 

aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc   3180 

tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg   3240 

ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac   3300 

aactgggtaa a                                                        3311 

 
           
             48  
             3697  
             DNA  
             human  
           
            48 

agggagtgtt cccgggggag atactccagt cgtagcaaga gtctcgacca ctgaatggaa     60 

gaaaaggact tttaaccacc attttgtgac ttacagaaag gaatttgaat aaagaaaact    120 

atgatacttc aggcccatct tcactccctg tgtcttctta tgctttattt ggcaactgga    180 

tatggccaag aggggaagtt tagtggaccc ctgaaaccca tgacattttc tatttatgaa    240 

ggccaagaac cgagtcaaat tatattccag tttaaggcca atcctcctgc tgtgactttt    300 

gaactaactg gggagacaga caacatattt gtgatagaac gggagggact tctgtattac    360 

aacagagcct tggacaggga aacaagatct actcacaatc tccaggttgc agccctggac    420 

gctaatggaa ttatagtgga gggtccagtc cctatcacca tagaagtgaa ggacatcaac    480 

gacaatcgac ccacgtttct ccagtcaaag tacgaaggct cagtaaggca gaactctcgc    540 

ccaggaaagc ccttcttgta tgtcaatgcc acagacctgg atgatccggc cactcccaat    600 

ggccagcttt attaccagat tgtcatccag cttcccatga tcaacaatgt catgtacttt    660 

cagatcaaca acaaaacggg agccatctct cttacccgag agggatctca ggaattgaat    720 

cctgctaaga atccttccta taatctggtg atctcagtga aggacatggg aggccagagt    780 

gagaattcct tcagtgatac cacatctgtg gatatcatag tgacagagaa tatttggaaa    840 

gcaccaaaac ctgtggagat ggtggaaaac tcaactgatc ctcaccccat caaaatcact    900 

caggtgcggt ggaatgatcc cggtgcacaa tattccttag ttgacaaaga gaagctgcca    960 

agattcccat tttcaattga ccaggaagga gatatttacg tgactcagcc cttggaccga   1020 

gaagaaaagg atgcatatgt tttttatgca gttgcaaagg atgagtacgg aaaaccactt   1080 

tcatatccgc tggaaattca tgtaaaagtt aaagatatta atgataatcc acctacatgt   1140 

ccgtcaccag taaccgtatt tgaggtccag gagaatgaac gactgggtaa cagtatcggg   1200 

acccttactg cacatgacag ggatgaagaa aatactgcca acagttttct aaactacagg   1260 

attgtggagc aaactcccaa acttcccatg gatggactct tcctaatcca aacctatgct   1320 

ggaatgttac agttagctaa acagtccttg aagaagcaag atactcctca gtacaactta   1380 

acgatagagg tgtctgacaa agatttcaag accctttgtt ttgtgcaaat caacgttatt   1440 

gatatcaatg atcagatccc catctttgaa aaatcagatt atggaaacct gactcttgct   1500 

gaagacacaa acattgggtc caccatctta accatccagg ccactgatgc tgatgagcca   1560 

tttactggga gttctaaaat tctgtatcat atcataaagg gagacagtga gggacgcctg   1620 

ggggttgaca cagatcccca taccaacacc ggatatgtca taattaaaaa gcctcttgat   1680 

tttgaaacag cagctgtttc caacattgtg ttcaaagcag aaaatcctga gcctctagtg   1740 

tttggtgtga agtacaatgc aagttctttt gccaagttca cgcttattgt gacagatgtg   1800 

aatgaagcac ctcaattttc ccaacacgta ttccaagcga aagtcagtga ggatgtagct   1860 

ataggcacta aagtgggcaa tgtgactgcc aaggatccag aaggtctgga cataagctat   1920 

tcactgaggg gagacacaag aggttggctt aaaattgacc acgtgactgg tgagatcttt   1980 

agtgtggctc cattggacag agaagccgga agtccatatc gggtacaagt ggtggccaca   2040 

gaagtagggg ggtcttcctt gagctctgtg tcagagttcc acctgatcct tatggatgtg   2100 

aatgacaacc ctcccaggct agccaaggac tacacgggct tgttcttctg ccatcccctc   2160 

agtgcacctg gaagtctcat tttcgaggct actgatgatg atcagcactt atttcggggt   2220 

ccccatttta cattttccct cggcagtgga agcttacaaa acgactggga agtttccaaa   2280 

atcaatggta ctcatgcccg actgtctacc aggcacacag agtttgagga gagggagtat   2340 

gtcgtcttga tccgcatcaa tgatgggggt cggccaccct tggaaggcat tgtttcttta   2400 

ccagttacat tctgcagttg tgtggaagga agttgtttcc ggccagcagg tcaccagact   2460 

gggataccca ctgtgggcat ggcagttggt atactgctga ccacccttct ggtgattggt   2520 

ataattttag cagttgtgtt tatccgcata aagaaggata aaggcaaaga taatgttgaa   2580 

agtgctcaag catctgaagt caaacctctg agaagctgaa tttgaaaagg aatgtttgaa   2640 

tttatatagc aagtgctatt tcagcaacaa ccatctcatc ctattacttt tcatctaacg   2700 

tgcattataa ttttttaaac agatattccc tcttgtcctt taatatttgc taaatatttc   2760 

ttttttgagg tggagtcttg ctctgtcgcc caggctggag tacagtggtg tgatcccagc   2820 

tcactgcaac ctccgcctcc tgggttcaca tgattctcct gcctcagctt cctaagtagc   2880 

tgggtttaca ggcacccacc accatgccca gctaattttt gtatttttaa tagagacggg   2940 

gtttcgccat ttggccaggc tggtcttgaa ctcctgacgt caagtgatct gcctgccttg   3000 

gtctcccaat acaggcatga accactgcac ccacctactt agatatttca tgtgctatag   3060 

acattagaga gatttttcat ttttccatga catttttcct ctctgcaaat ggcttagcta   3120 

cttgtgtttt tcccttttgg ggcaagacag actcattaaa tattctgtac attttttctt   3180 

tatcaaggag atatatcagt gttgtctcat agaactgcct ggattccatt tatgtttttt   3240 

ctgattccat cctgtgtccc cttcatcctt gactcctttg gtatttcact gaatttcaaa   3300 

catttgtcag agaagaaaaa cgtgaggact caggaaaaat aaataaataa aagaacagcc   3360 

ttttccctta gtattaacag aaatgtttct gtgtcattaa ccatctttaa tcaatgtgac   3420 

atgttgctct ttggctgaaa ttcttcaact tggaaatgac acagacccac agaaggtgtt   3480 

caaacacaac ctactctgca aaccttggta aaggaaccag tcagctggcc agatttcctc   3540 

actacctgcc atgcatacat gctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt   3600 

ggttattata tatttaacat gtggaagaaa acaagacatg aaaagagtgg tgacaaatca   3660 

agaataaaca ctggttgtag tcagttttgt ttgttaa                            3697 

 
           
             49  
             3697  
             DNA  
             human  
           
            49 

agggagtgtt cccgggggag atactccagt cgtagcaaga gtctcgacca ctgaatggaa     60 

gaaaaggact tttaaccacc attttgtgac ttacagaaag gaatttgaat aaagaaaact    120 

atgatacttc aggcccatct tcactccctg tgtcttctta tgctttattt ggcaactgga    180 

tatggccaag aggggaagtt tagtggaccc ctgaaaccca tgacattttc tatttatgaa    240 

ggccaagaac cgagtcaaat tatattccag tttaaggcca atcctcctgc tgtgactttt    300 

gaactaactg gggagacaga caacatattt gtgatagaac gggagggact tctgtattac    360 

aacagagcct tggacaggga aacaagatct actcacaatc tccaggttgc agccctggac    420 

gctaatggaa ttatagtgga gggtccagtc cctatcacca tagaagtgaa ggacatcaac    480 

gacaatcgac ccacgtttct ccagtcaaag tacgaaggct cagtaaggca gaactctcgc    540 

ccaggaaagc ccttcttgta tgtcaatgcc acagacctgg atgatccggc cactcccaat    600 

ggccagcttt attaccagat tgtcatccag cttcccatga tcaacaatgt catgtacttt    660 

cagatcaaca acaaaacggg agccatctct cttacccgag agggatctca ggaattgaat    720 

cctgctaaga atccttccta taatctggtg atctcagtga aggacatggg aggccagagt    780 

gagaattcct tcagtgatac cacatctgtg gatatcatag tgacagagaa tatttggaaa    840 

gcaccaaaac ctgtggagat ggtggaaaac tcaactgatc ctcaccccat caaaatcact    900 

caggtgcggt ggaatgatcc cggtgcacaa tattccttag ttgacaaaga gaagctgcca    960 

agattcccat tttcaattga ccaggaagga gatatttacg tgactcagcc cttggaccga   1020 

gaagaaaagg atgcatatgt tttttatgca gttgcaaagg atgagtacgg aaaaccactt   1080 

tcatatccgc tggaaattca tgtaaaagtt aaagatatta atgataatcc acctacatgt   1140 

ccgtcaccag taaccgtatt tgaggtccag gagaatgaac gactgggtaa cagtatcggg   1200 

acccttactg cacatgacag ggatgaagaa aatactgcca acagttttct aaactacagg   1260 

attgtggagc aaactcccaa acttcccatg gatggactct tcctaatcca aacctatgct   1320 

ggaatgttac agttagctaa acagtccttg aagaagcaag atactcctca gtacaactta   1380 

acgatagagg tgtctgacaa agatttcaag accctttgtt ttgtgcaaat caacgttatt   1440 

gatatcaatg atcagatccc catctttgaa aaatcagatt atggaaacct gactcttgct   1500 

gaagacacaa acattgggtc caccatctta accatccagg ccactgatgc tgatgagcca   1560 

tttactggga gttctaaaat tctgtatcat atcataaagg gagacagtga gggacgcctg   1620 

ggggttgaca cagatcccca taccaacacc ggatatgtca taattaaaaa gcctcttgat   1680 

tttgaaacag cagctgtttc caacattgtg ttcaaagcag aaaatcctga gcctctagtg   1740 

tttggtgtga agtacaatgc aagttctttt gccaagttca cgcttattgt gacagatgtg   1800 

aatgaagcac ctcaattttc ccaacacgta ttccaagcga aagtcagtga ggatgtagct   1860 

ataggcacta aagtgggcaa tgtgactgcc aaggatccag aaggtctgga cataagctat   1920 

tcactgaggg gagacacaag aggttggctt aaaattgacc acgtgactgg tgagatcttt   1980 

agtgtggctc cattggacag agaagccgga agtccatatc gggtacaagt ggtggccaca   2040 

gaagtagggg ggtcttcctt gagctctgtg tcagagttcc acctgatcct tatggatgtg   2100 

aatgacaacc ctcccaggct agccaaggac tacacgggct tgttcttctg ccatcccctc   2160 

agtgcacctg gaagtctcat tttcgaggct actgatgatg atcagcactt atttcggggt   2220 

ccccatttta cattttccct cggcagtgga agcttacaaa acgactggga agtttccaaa   2280 

atcaatggta ctcatgcccg actgtctacc aggcacacag agtttgagga gagggagtat   2340 

gtcgtcttga tccgcatcaa tgatgggggt cggccaccct tggaaggcat tgtttcttta   2400 

ccagttacat tctgcagttg tgtggaagga agttgtttcc ggccagcagg tcaccagact   2460 

gggataccca ctgtgggcat ggcagttggt atactgctga ccacccttct ggtgattggt   2520 

ataattttag cagttgtgtt tatccgcata aagaaggata aaggcaaaga taatgttgaa   2580 

agtgctcaag catctgaagt caaacctctg agaagctgaa tttgaaaagg aatgtttgaa   2640 

tttatatagc aagtgctatt tcagcaacaa ccatctcatc ctattacttt tcatctaacg   2700 

tgcattataa ttttttaaac agatattccc tcttgtcctt taatatttgc taaatatttc   2760 

ttttttgagg tggagtcttg ctctgtcgcc caggctggag tacagtggtg tgatcccagc   2820 

tcactgcaac ctccgcctcc tgggttcaca tgattctcct gcctcagctt cctaagtagc   2880 

tgggtttaca ggcacccacc accatgccca gctaattttt gtatttttaa tagagacggg   2940 

gtttcgccat ttggccaggc tggtcttgaa ctcctgacgt caagtgatct gcctgccttg   3000 

gtctcccaat acaggcatga accactgcac ccacctactt agatatttca tgtgctatag   3060 

acattagaga gatttttcat ttttccatga catttttcct ctctgcaaat ggcttagcta   3120 

cttgtgtttt tcccttttgg ggcaagacag actcattaaa tattctgtac attttttctt   3180 

tatcaaggag atatatcagt gttgtctcat agaactgcct ggattccatt tatgtttttt   3240 

ctgattccat cctgtgtccc cttcatcctt gactcctttg gtatttcact gaatttcaaa   3300 

catttgtcag agaagaaaaa cgtgaggact caggaaaaat aaataaataa aagaacagcc   3360 

ttttccctta gtattaacag aaatgtttct gtgtcattaa ccatctttaa tcaatgtgac   3420 

atgttgctct ttggctgaaa ttcttcaact tggaaatgac acagacccac agaaggtgtt   3480 

caaacacaac ctactctgca aaccttggta aaggaaccag tcagctggcc agatttcctc   3540 

actacctgcc atgcatacat gctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt   3600 

ggttattata tatttaacat gtggaagaaa acaagacatg aaaagagtgg tgacaaatca   3660 

agaataaaca ctggttgtag tcagttttgt ttgttaa                            3697 

 
           
             50  
             3803  
             DNA  
             human  
           
            50 

ccatggtagg agcgctcgcc tcgctgcggt gcccgctgag gccatgccgg ggccccggcg     60 

ccccgctggc tcccgcctgc gcctgctcct gctcctgctg ctgccgccgc tgctgctgct    120 

gctccggggc agccacgcgg gcaacctgac ggtagccgtg gtactgccgc tggccaatac    180 

ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtg gagctggccc tggcccaggt    240 

gaaggcgcgc cccgacttgc tgccgggctg gacggtccgc acggtgctgg gcagcagcga    300 

aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctg gccgcggtgg acctcaagtg    360 

ggagcacaac cccgctgtgt tcctgggccc cggctgcgtg tacgccgccg ccccagtggg    420 

gcgcttcacc gcgcactggc gggtcccgct gctgaccgcc ggcgccccgg cgctgggctt    480 

cggtgtcaag gacgagtatg cgctgaccac ccgcgcgggg cccagctacg ccaagctggg    540 

ggacttcgtg gcggcgctgc accgacggct gggctgggag cgccaagcgc tcatgctcta    600 

cgcctaccgg ccgggtgacg aagagcactg cttcttcctc gtggaggggc tgttcatgcg    660 

ggtccgcgac cgcctcaata ttacggtgga ccacctggag ttcgccgagg acgacctcag    720 

ccactacacc aggctgctgc ggaccatgcc gcgcaaaggc cgagttatct acatctgcag    780 

ctcccctgat gccttcagaa ccctcatgct cctggccctg gaagctggct tgtgtgggga    840 

ggactacgtt ttcttccacc tggatatctt tgggcaaagc ctgcaaggtg gacagggccc    900 

tgctccccgc aggccctggg agagagggga tgggcaggat gtcagtgccc gccaggcctt    960 

tcaggctgcc aaaatcatta catataaaga cccagataat cccgagtact tggaattcct   1020 

gaagcagtta aaacacctgg cctatgagca gttcaacttc accatggagg atggcctggt   1080 

gaacaccatc ccagcatcct tccacgacgg gctcctgctc tatatccagg cagtgacgga   1140 

gactctggca catgggggaa ctgttactga tggggagaac atcactcagc ggatgtggaa   1200 

ccgaagcttt caaggtgtga caggatacct gaaaattgat agcagtggcg atcgggaaac   1260 

agacttctcc ctctgggata tggatcccga gaatggtgcc ttcagggttg tactgaacta   1320 

caatgggact tcccaagagc tggtggctgt gtcggggcgc aaactgaact ggcccctggg   1380 

gtaccctcct cctgacatcc ccaaatgtgg ctttgacaac gaagacccag catgcaacca   1440 

agatcacctt tccaccctgg aggtgctggc tttggtgggc agcctctcct tgctcggcat   1500 

tctgattgtc tccttcttca tatacaggaa gatgcagctg gagaaggaac tggcctcgga   1560 

gctgtggcgg gtgcgctggg aggacgttga gcccagtagc cttgagaggc acctgcggag   1620 

tgcaggcagc cggctgaccc tgagcgggag aggctccaat tacggctccc tgctaaccac   1680 

agagggccag ttccaagtct ttgccaagac agcatattat aagggcaacc tcgtggctgt   1740 

gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaa gtcctgtttg aactgaagca   1800 

tatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgca ccgacccccc   1860 

caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggaca ttctggagaa   1920 

tgagagcatc accctggact ggatgttccg gtactcactc accaatgaca tcgtcaaggg   1980 

catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagt catccaactg   2040 

cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggaga gcttcaggga   2100 

cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacgg cccctgagct   2160 

cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtat acagctttgg   2220 

gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaag gtttggacct   2280 

gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagcccccct tccggccctc   2340 

cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggt gctgggctga   2400 

ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgca aatttaacag   2460 

ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagt acgcgaacaa   2520 

tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagc gcaaggctga   2580 

ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagc gtggggagac   2640 

ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattg tgggtttcac   2700 

agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatg acctgtacac   2760 

ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaa ttggcgatgc   2820 

ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc   2880 

ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgcc accggcccca   2940 

ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctg gagtggtggg   3000 

actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcct caagaatgga   3060 

gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctg tcctggagga   3120 

gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggca aaggcaaggt   3180 

tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgac ctgcctcctc   3240 

tcctatccct ccacacctcc cctaccctgt gccagaagca acagaggtgc caggcctcag   3300 

cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagc tcaggtgtgc   3360 

tgaccccagt gaagacacca gataggacct ctgagagggg actggcatgg ggggatctca   3420 

gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacac aggcacacgc   3480 

acctgctctc cacctggact caggccgggc tgggctgtgg atccttgatc ccctcccctc   3540 

cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggag agtcacctga   3600 

aggggaacat gaaaagagac taggtgaaga gagggcaggg gagcccacat ctggggctgg   3660 

cccacaatac ctgctccccc gaccccctcc acccagcagt agacacagtg cacaggggag   3720 

aagaggggtg gcgcagaagg gttgggggcc tgtatgcctt gcttctacca tgagcagaga   3780 

caattaaaat ctttattcca gtg                                           3803 

 
           
             51  
             3803  
             DNA  
             human  
           
            51 

ccatggtagg agcgctcgcc tcgctgcggt gcccgctgag gccatgccgg ggccccggcg     60 

ccccgctggc tcccgcctgc gcctgctcct gctcctgctg ctgccgccgc tgctgctgct    120 

gctccggggc agccacgcgg gcaacctgac ggtagccgtg gtactgccgc tggccaatac    180 

ctcgtacccc tggtcgtggg cgcgcgtggg acccgccgtg gagctggccc tggcccaggt    240 

gaaggcgcgc cccgacttgc tgccgggctg gacggtccgc acggtgctgg gcagcagcga    300 

aaacgcgctg ggcgtctgct ccgacaccgc agcgcccctg gccgcggtgg acctcaagtg    360 

ggagcacaac cccgctgtgt tcctgggccc cggctgcgtg tacgccgccg ccccagtggg    420 

gcgcttcacc gcgcactggc gggtcccgct gctgaccgcc ggcgccccgg cgctgggctt    480 

cggtgtcaag gacgagtatg cgctgaccac ccgcgcgggg cccagctacg ccaagctggg    540 

ggacttcgtg gcggcgctgc accgacggct gggctgggag cgccaagcgc tcatgctcta    600 

cgcctaccgg ccgggtgacg aagagcactg cttcttcctc gtggaggggc tgttcatgcg    660 

ggtccgcgac cgcctcaata ttacggtgga ccacctggag ttcgccgagg acgacctcag    720 

ccactacacc aggctgctgc ggaccatgcc gcgcaaaggc cgagttatct acatctgcag    780 

ctcccctgat gccttcagaa ccctcatgct cctggccctg gaagctggct tgtgtgggga    840 

ggactacgtt ttcttccacc tggatatctt tgggcaaagc ctgcaaggtg gacagggccc    900 

tgctccccgc aggccctggg agagagggga tgggcaggat gtcagtgccc gccaggcctt    960 

tcaggctgcc aaaatcatta catataaaga cccagataat cccgagtact tggaattcct   1020 

gaagcagtta aaacacctgg cctatgagca gttcaacttc accatggagg atggcctggt   1080 

gaacaccatc ccagcatcct tccacgacgg gctcctgctc tatatccagg cagtgacgga   1140 

gactctggca catgggggaa ctgttactga tggggagaac atcactcagc ggatgtggaa   1200 

ccgaagcttt caaggtgtga caggatacct gaaaattgat agcagtggcg atcgggaaac   1260 

agacttctcc ctctgggata tggatcccga gaatggtgcc ttcagggttg tactgaacta   1320 

caatgggact tcccaagagc tggtggctgt gtcggggcgc aaactgaact ggcccctggg   1380 

gtaccctcct cctgacatcc ccaaatgtgg ctttgacaac gaagacccag catgcaacca   1440 

agatcacctt tccaccctgg aggtgctggc tttggtgggc agcctctcct tgctcggcat   1500 

tctgattgtc tccttcttca tatacaggaa gatgcagctg gagaaggaac tggcctcgga   1560 

gctgtggcgg gtgcgctggg aggacgttga gcccagtagc cttgagaggc acctgcggag   1620 

tgcaggcagc cggctgaccc tgagcgggag aggctccaat tacggctccc tgctaaccac   1680 

agagggccag ttccaagtct ttgccaagac agcatattat aagggcaacc tcgtggctgt   1740 

gaaacgtgtg aaccgtaaac gcattgagct gacacgaaaa gtcctgtttg aactgaagca   1800 

tatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgca ccgacccccc   1860 

caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggaca ttctggagaa   1920 

tgagagcatc accctggact ggatgttccg gtactcactc accaatgaca tcgtcaaggg   1980 

catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagt catccaactg   2040 

cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggaga gcttcaggga   2100 

cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacgg cccctgagct   2160 

cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtat acagctttgg   2220 

gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaag gtttggacct   2280 

gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagcccccct tccggccctc   2340 

cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggt gctgggctga   2400 

ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgca aatttaacag   2460 

ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagt acgcgaacaa   2520 

tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagc gcaaggctga   2580 

ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagc gtggggagac   2640 

ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattg tgggtttcac   2700 

agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatg acctgtacac   2760 

ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaa ttggcgatgc   2820 

ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc   2880 

ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgcc accggcccca   2940 

ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctg gagtggtggg   3000 

actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcct caagaatgga   3060 

gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctg tcctggagga   3120 

gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggca aaggcaaggt   3180 

tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgac ctgcctcctc   3240 

tcctatccct ccacacctcc cctaccctgt gccagaagca acagaggtgc caggcctcag   3300 

cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagc tcaggtgtgc   3360 

tgaccccagt gaagacacca gataggacct ctgagagggg actggcatgg ggggatctca   3420 

gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacac aggcacacgc   3480 

acctgctctc cacctggact caggccgggc tgggctgtgg atccttgatc ccctcccctc   3540 

cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggag agtcacctga   3600 

aggggaacat gaaaagagac taggtgaaga gagggcaggg gagcccacat ctggggctgg   3660 

cccacaatac ctgctccccc gaccccctcc acccagcagt agacacagtg cacaggggag   3720 

aagaggggtg gcgcagaagg gttgggggcc tgtatgcctt gcttctacca tgagcagaga   3780 

caattaaaat ctttattcca gtg                                           3803 

 
           
             52  
             1155  
             DNA  
             human  
           
            52 

atggattgca gtaacggatc ggcagagtgt accggagaag gaggatcaaa agaggtggtg     60 

gggactttta aggctaaaga cctaatagtc acaccagcta ccattttaaa ggaaaaacca    120 

gaccccaata atctggtttt tggaactgtg ttcacggatc atatgctgac ggtggagtgg    180 

tcctcagagt ttggatggga gaaacctcat atcaagcctc ttcagaacct gtcattgcac    240 

cctggctcat cagctttgca ctatgcagtg gaattatttg aaggattgaa ggcatttcga    300 

ggagtagata ataaaattcg actgtttcag ccaaacctca acatggatag aatgtatcgc    360 

tctgctgtga gggcaactct gccggtattt gacaaagaag agctcttaga gtgtattcaa    420 

cagcttgtga aattggatca agaatgggtc ccatattcaa catctgctag tctgtatatt    480 

cgtcctgcat tcattggaac tgagccttct cttggagtca agaagcctac caaagccctg    540 

ctctttgtac tcttgagccc agtgggacct tatttttcaa gtggaacctt taatccagtg    600 

tccctgtggg ccaatcccaa gtatgtaaga gcctggaaag gtggaactgg ggactgcaag    660 

atgggaggga attacggctc atctcttttt gcccaatgtg aagacgtaga taatgggtgt    720 

cagcaggtcc tgtggctcta tggcagagac catcagatca ctgaagtggg aactatgaat    780 

ctttttcttt actggataaa tgaagatgga gaagaagaac tggcaactcc tccactagat    840 

ggcatcattc ttccaggagt gacaaggcgg tgcattctgg acctggcaca tcagtggggt    900 

gaatttaagg tgtcagagag atacctcacc atggatgact tgacaacagc cctggagggg    960 

aacagagtga gagagatgtt tagctctggt acagcctgtg ttgtttgccc agtttctgat   1020 

atactgtaca aaggcgagac aatacacatt ccaactatgg agaatggtcc taagctggca   1080 

agccgcatct tgagcaaatt aactgatatc cagtatggaa gagaagagag cgactggaca   1140 

attgtgctat cctga                                                    1155 

 
           
             53  
             2511  
             DNA  
             human  
           
            53 

cttttcacac tggccttaaa gaggatatat tagaagttga agtaggaagg gagccagaga     60 

ggccgatggc gcaaaggtac gacgatctac cccattacgg gggcatggat ggagtaggca    120 

tcccctccac gatgtatggg gacccgcatg cagccaggtc catgcagccg gtccaccacc    180 

tgaaccacgg gcctcctctg cactcgcatc agtacccgca cacagctcat accaacgcca    240 

tggcccccag catgggctcc tctgtcaatg acgctttaaa gagagataaa gatgccattt    300 

atggacaccc cctcttccct ctcttagcac tgatttttga gaaatgtgaa ttagctactt    360 

gtaccccccg cgagccgggg gtggcgggcg gggacgtctg ctcgtcagag tcattcaatg    420 

aagatatagc cgtgttcgcc aaacagattc gcgcagaaaa acctctattt tcttctaatc    480 

cagaactgga taacttgatg attcaagcca tacaagtatt aaggtttcat ctattggaat    540 

tagagaaggt acacgaatta tgtgacaatt tctgccaccg gtatattagc tgtttgaaag    600 

ggaaaatgcc tatcgatttg gtgatagacg atagagaagg aggatcaaaa tcagacagtg    660 

aagatataac aagatcagca aatctaactg accagccctc ttggaacaga gatcatgatg    720 

acacggcatc tactcgttca ggaggaaccc caggcccttc cagcggtggc cacacgtcac    780 

acagtgggga caacagcagt gagcaaggtg atggcttgga caacagtgta gcttccccca    840 

gcacaggtga cgatgatgac cctgataagg acaaaaagcg tcacaaaaag cgtggcatct    900 

ttcccaaagt agccacaaat atcatgaggg cgtggctgtt ccagcatcta acacaccctt    960 

acccttctga agaacagaaa aagcagttgg cacaagacac gggactcacc atccttcaag   1020 

tgaacaattg gtttattaat gcccggagaa gaatagtgca gcccatgata gaccagtcca   1080 

accgagcagt aagtcaagga acaccttata atcctgatgg acagcccatg ggaggtttcg   1140 

taatggacgg tcagcaacat atgggaatta gagcaccagg acctatgagt ggaatgggca   1200 

tgaatatggg catggagggg cagtggcact acatgtaacc ttcatctagt taaccaatcg   1260 

caaagcaagg gggaaggctg caaagtatgc caggggagta tgtagcccgg ggtggtccaa   1320 

tgggtgtgag tatgggacag ccaagttata cccaacccca gatgcccccc catcctgctc   1380 

agctgcgtca tgggcccccc atgcatacgt acattcctgg acaccctcac cacccaacag   1440 

tgatgatgca tggaggaccg ccccaccctg gaatgccaat gtcagcatca agccccacag   1500 

ttcttaatac aggagaccca acaatgagtg gacaagtcat ggacattcat gctcagtagc   1560 

ttaagggaat atgcattgtc tgcaatggtg actgatttca aatcatgttt tttctgcaat   1620 

gactgtggag ttccattctt ggcatctact ctggaccaag gagcatccct aattcttcat   1680 

agggaccttt aaaaagcagg aaataccaac tgaagtcaat ttgggggaca tgctaaataa   1740 

ctatataaga cattaagaga acaaagagtg aaatattgta aatgctatta tactgttatc   1800 

catattacgt tgtttcttat agatttttta aaaaaaatgt gaaatttttc cacactatgt   1860 

gtgttgtttc catagctctt cacttcctcc agaagcctcc ttacattaaa aagccttaca   1920 

gttatcctgc aagggacagg aaggtctgat ttgcaggatt tttagagcat taaaataact   1980 

atcaggcaga agaatctttc ttctcgccta ggatttcagc catgcgcgcg ctctctctct   2040 

ttctctctct tttcctctct ctccctcttt ctagcctggg gcttgaattt gcatgtctaa   2100 

ttcatttact caccatattt gaattggcct gaacagatgt aaatcgggaa ggatgggaaa   2160 

aactgcagtc atcaacaatg attaatcagc tgttgcaggc agtgtcttaa ggagactggt   2220 

aggaggaggc atggaaacca aaaggccgtg tgtttagaag cctaattgtc acatcaagca   2280 

tcattgtccc catgcaacaa ccaccacctt atacatcact tcctgtttta agcagctcta   2340 

aaacatagac tgaagattta tttttaatat gttgacttta tttctgagca aagcatcggt   2400 

catgtgtgta ttttttcata gtcccacctt ggagcattta tgtagacatt gtaaataaat   2460 

tttgtgcaaa aaggactgga aaaatgaact gtattattgc aatttttttt t            2511 

 
           
             54  
             1887  
             DNA  
             human  
           
            54 

tcgcccaatt ccgggctcag acactgggct cccagctggg gactgctcca tggccatgga     60 

gatagacagc aggcctgggg ggctccccgg cagtagctgc aacctaggtg cagcccgaga    120 

acacatgcag gcggtcaccc gaaactacat cacccacccc cgtgtcacct acaggactgt    180 

gtgcagcgtg aacgggcccc tggtggtgct ggaccgggtc aagtttgccc agtatgcgga    240 

gatcgtccac ttcaccctcc cagatgggac tcagaggagc gggcaggtgc ttgaggtggc    300 

tggcaccaag gcgattgttc aggtgtttga agggacatca gggatcgatg ccaggaagac    360 

cacttgcgaa tttacagggg acatcctacg aactccggtg tcagaggaca tgctgggtcg    420 

ggttttcaat ggctccggca agcccattga caaggggcca gtggtcatgg cggaggactt    480 

tctggatatc aatggccagc ccatcaaccc gcactcccgc atctaccccg aggagatgat    540 

tcagacgggc atttctccta ttgacgtcat gaacagcatt gcccgcggcc agaagatccc    600 

catcttctca gcagccgggc tcccccacaa tgagattgcc gctcagatct gccgccaggc    660 

ggggctggtg aagaagtcca aggctgtgct ggattaccat gacgacaact tcgccatcgt    720 

ctttgcagcc atgggggtga acatggagac agccagattc ttcaagtctg actttgagca    780 

gaatggaacc atggggaacg tctgcctctt cctgaacttg gccaatgacc ccacgatcga    840 

gcggatcatc accccgcgcc tggcgctgac cactgctgaa ttccttgcct accagtgtga    900 

gaagcatgtg ctggtcatac tgacggacat gagttcctat gcagaggcct tgcgggaggt    960 

ctctgctgct agagaggagg tgcctgggcg ccgagggttt cctggatata tgtacacaga   1020 

cctggccacc atctacgagc gggcgggccg tgtggagggt cggggaggat ccatcacaca   1080 

gatccccatc ctcaccatgc ccaacgacga tatcacccac cctatcccag acttgacggg   1140 

cttcatcaca gagggacaga tctacgtgga cagacagctt cacaacagac agatctaccc   1200 

ccccatcaac gtgctccctt ccctgtcgcg gctgatgaag tcagccattg gggaaggcat   1260 

gacaagaaag gaccatggag atgtctccaa ccagctgtac gcctgctatg ccatcgggaa   1320 

ggacgtgcag gccatgaagg cagtagttgg ggaggaggcg ctcacctctg aggacctgct   1380 

ctacctggaa ttcctgcaga agtttgagaa gaacttcatc aatcagggcc cctacgagaa   1440 

ccgctcgatg ttcgagtcgc tggaccttag ctggaagctg ctgcgcatct tccccaagga   1500 

gatgctgaag cgcattccgc aggccgtgat cgacgagttc tattcccgcg aggggcggct   1560 

gcaggacctc gcgcctgaca ctgcgctcta gccccgcgcg ccgtggcacc ccaacaccgg   1620 

caggaaccta ccctcggctc ccgggtctcc ccgtccctcg ccacccctaa ccagcggctt   1680 

tcgcgccgcc ctccgccctc cgtggctccg aggtggtggg gggcgccgca gtcatccctt   1740 

tcctcgctcg attccttttc ccgcgctcca tgcctccccc tcagctcccg gtgctgcgga   1800 

agaactgaag gttcatgcct actctgacgg gagcatctgt attttttatg ttaaaagccc   1860 

acaaaataaa aataaaaatg aactgag                                       1887 

 
           
             55  
             1506  
             DNA  
             human  
           
            55 

aggcggacaa agcccgattg ttcctgggcc ctttccccat cgcgcctggg cctgctcccc     60 

agcccggggc aggggcgggg gccagtgtgg tgacacacgc tgtagctgtc tccccggctg    120 

gctggctcgc tctctcctgg ggacacagag gtcggcaggc agcacacaga gggacctacg    180 

ggcagctgtt ccttcccccg actcaagaat ccccggaggc ccggaggcct gcagcaggag    240 

cggccatgaa gaagctgatg gtggtgctga gtctgattgc tgcagcctgg gcagaggagc    300 

agaataagtt ggtgcatggc ggaccctgcg acaagacatc tcacccctac caagctgccc    360 

tctacacctc gggccacttg ctctgtggtg gggtccttat ccatccactg tgggtcctca    420 

cagctgccca ctgcaaaaaa ccgaatcttc aggtcttcct ggggaagcat aaccttcggc    480 

aaagggagag ttcccaggag cagagttctg ttgtccgggc tgtgatccac cctgactatg    540 

atgccgccag ccatgaccag gacatcatgc tgttgcgcct ggcacgccca gccaaactct    600 

ctgaactcat ccagcccctt cccctggaga gggactgctc agccaacacc accagctgcc    660 

acatcctggg ctggggcaag acagcagatg gtgatttccc tgacaccatc cagtgtgcat    720 

acatccacct ggtgtcccgt gaggagtgtg agcatgccta ccctggccag atcacccaga    780 

acatgttgtg tgctggggat gagaagtacg ggaaggattc ctgccagggt gattctgggg    840 

gtccgctggt atgtggagac cacctccgag gccttgtgtc atggggtaac atcccctgtg    900 

gatcaaagga gaagccagga gtctacacca acgtctgcag atacacgaac tggatccaaa    960 

aaaccattca ggccaagtga ccctgacatg tgacatctac ctcccgacct accaccccac   1020 

tggctggttc cagaacgtct ctcacctaga ccttgcctcc cctcctctcc tgcccagctc   1080 

tgaccctgat gcttaataaa cgcagcgacg tgagggtcct gattctccct ggttttaccc   1140 

cagctccatc cttgcatcac tggggaggac gtgatgagtg aggacttggg tcctcggtct   1200 

tacccccacc actaagagaa tacaggaaaa tcccttctag gcatctcctc tccccaaccc   1260 

ttccacacgt ttgatttctt cctgcagagg cccagccacg tgtctggaat cccagctccg   1320 

ctgcttactg tcggtgtccc cttgggatgt acctttcttc actgcagatt tctcacctgt   1380 

aagatgaaga taaggatgat acagtctcca tcaggcagtg gctgttggaa agatttaaga   1440 

tttcacacct atgacataca tgggatagca cctgggccgc catgcactca ataaagaatg   1500 

tatttt                                                              1506 

 
           
             56  
             2907  
             DNA  
             human  
           
            56 

gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagccca ccagagcccc     60 

ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccag caacagcagc    120 

tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctcc ctacgccttc    180 

ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccac tctccagcac    240 

cagcttccag ttagtggata tagcacacca tccccagcca ccattgagac ccagagcagc    300 

agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccg catctacaag    360 

ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcag cgcctgtgag    420 

ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg    480 

gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactg ccgactgcag    540 

aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaa caagaagaag    600 

aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccgga ggtgggggag    660 

ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctg ccagctgggc    720 

aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattga cctctgggac    780 

aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgc caagcagctg    840 

cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggc tgcctgcctg    900 

gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacac catgaccttc    960 

tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcgg ccccctcacc   1020 

gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatga tgcggagacg   1080 

gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctgga gcagccggac   1140 

cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgt gcggaagcgg   1200 

aggcccagcc gcccccacat gttccccaag atgctaatga agattactga cctgcgaagc   1260 

atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatccc gggctccatg   1320 

ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactct gagcggacag   1380 

ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcag ctgtagcccc   1440 

agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtg accgcccacg   1500 

ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttct accgaccatg   1560 

tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactgggg accttccctg   1620 

ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccc tcagtggact   1680 

gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactga gtgaggcccc   1740 

tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagaca cccctctgcc   1800 

cagctcacca catcttcatc accagcaaac gccaggactt ggctccccca tcctcagaac   1860 

tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctc ggttggtgac   1920 

agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccat accaacccca   1980 

ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgat ttttttaata   2040 

agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtat tggggggagc   2100 

tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaag gggcccccac   2160 

tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcct cctcagtttt   2220 

ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccc tcccactgga   2280 

gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggt gtggggcagc   2340 

cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgag gcatggagca   2400 

gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcgg cagagctgcc   2460 

tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggg gctggccagg   2520 

ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccataggg cccccagaca   2580 

ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagt agatgggccg   2640 

acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccc caacctgtcc   2700 

cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtct cccctcaccc   2760 

ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccagg ggttggggcc   2820 

ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactg agatctactg   2880 

gataaagaat aaagttctat ttattct                                       2907 

 
           
             57  
             2907  
             DNA  
             human  
           
            57 

gccatctggg cccaggcccc atgccccgag gaggggtggt ctgaagccca ccagagcccc     60 

ctgccagact gtctgcctcc cttctgactg tggccgcttg gcatggccag caacagcagc    120 

tcctgcccga cacctggggg cgggcacctc aatgggtacc cggtgcctcc ctacgccttc    180 

ttcttccccc ctatgctggg tggactctcc ccgccaggcg ctctgaccac tctccagcac    240 

cagcttccag ttagtggata tagcacacca tccccagcca ccattgagac ccagagcagc    300 

agttctgaag agatagtgcc cagccctccc tcgccacccc ctctaccccg catctacaag    360 

ccttgctttg tctgtcagga caagtcctca ggctaccact atggggtcag cgcctgtgag    420 

ggctgcaagg gcttcttccg ccgcagcatc cagaagaaca tggtgtacac gtgtcaccgg    480 

gacaagaact gcatcatcaa caaggtgacc cggaaccgct gccagtactg ccgactgcag    540 

aagtgctttg aagtgggcat gtccaaggag tctgtgagaa acgaccgaaa caagaagaag    600 

aaggaggtgc ccaagcccga gtgctctgag agctacacgc tgacgccgga ggtgggggag    660 

ctcattgaga aggtgcgcaa agcgcaccag gaaaccttcc ctgccctctg ccagctgggc    720 

aaatacacta cgaacaacag ctcagaacaa cgtgtctctc tggacattga cctctgggac    780 

aagttcagtg aactctccac caagtgcatc attaagactg tggagttcgc caagcagctg    840 

cccggcttca ccaccctcac catcgccgac cagatcaccc tcctcaaggc tgcctgcctg    900 

gacatcctga tcctgcggat ctgcacgcgg tacacgcccg agcaggacac catgaccttc    960 

tcggacgggc tgaccctgaa ccggacccag atgcacaacg ctggcttcgg ccccctcacc   1020 

gacctggtct ttgccttcgc caaccagctg ctgcccctgg agatggatga tgcggagacg   1080 

gggctgctca gcgccatctg cctcatctgc ggagaccgcc aggacctgga gcagccggac   1140 

cgggtggaca tgctgcagga gccgctgctg gaggcgctaa aggtctacgt gcggaagcgg   1200 

aggcccagcc gcccccacat gttccccaag atgctaatga agattactga cctgcgaagc   1260 

atcagcgcca agggggctga gcgggtgatc acgctgaaga tggagatccc gggctccatg   1320 

ccgcctctca tccaggaaat gttggagaac tcagagggcc tggacactct gagcggacag   1380 

ccggggggtg gggggcggga cgggggtggc ctggcccccc cgccaggcag ctgtagcccc   1440 

agcctcagcc ccagctccaa cagaagcagc ccggccaccc actccccgtg accgcccacg   1500 

ccacatggac acagccctcg ccctccgccc cggcttttct ctgcctttct accgaccatg   1560 

tgaccccgca ccagccctgc ccccacctgc cctcccgggc agtactgggg accttccctg   1620 

ggggacgggg agggaggagg cagcgactcc ttggacagag gcctgggccc tcagtggact   1680 

gcctgctccc acagcctggg ctgacgtcag aggccgaggc caggaactga gtgaggcccc   1740 

tggtcctggg tctcaggatg ggtcctgggg gcctcgtgtt catcaagaca cccctctgcc   1800 

cagctcacca catcttcatc accagcaaac gccaggactt ggctccccca tcctcagaac   1860 

tcacaagcca ttgctcccca gctggggaac ctcaacctcc cccctgcctc ggttggtgac   1920 

agagggggtg ggacaggggc ggggggttcc ccctgtacat accctgccat accaacccca   1980 

ggtattaatt ctcgctggtt ttgtttttat tttaattttt ttgttttgat ttttttaata   2040 

agaattttca ttttaagcac atttatactg aaggaatttg tgctgtgtat tggggggagc   2100 

tggatccaga gctggagggg gtgggtccgg gggagggagt ggctcggaag gggcccccac   2160 

tctcctttca tgtccctgtg ccccccagtt ctcctcctca gccttttcct cctcagtttt   2220 

ctctttaaaa ctgtgaagta ctaactttcc aaggcctgcc ttcccctccc tcccactgga   2280 

gaagccgcca gcccctttct ccctctgcct gaccactggg tgtggacggt gtggggcagc   2340 

cctgaaagga caggctcctg gccttggcac ttgcctgcac ccaccatgag gcatggagca   2400 

gggcagagca agggccccgg gacagagttt tcccagacct ggctcctcgg cagagctgcc   2460 

tcccgtcagg gcccacatca tctaggctcc ccagccccca ctgtgaaggg gctggccagg   2520 

ggcccgagct gcccccaccc ccggcctcag ccaccagcac ccccataggg cccccagaca   2580 

ccacacacat gcgcgtgcgc acacacacaa acacacacac actggacagt agatgggccg   2640 

acacacactt ggcccgagtt cctccatttc cctggcctgc cccccacccc caacctgtcc   2700 

cacccccgtg ccccctcctt accccgcagg acgggcctac aggggggtct cccctcaccc   2760 

ctgcaccccc agctggggga gctggctctg ccccgacctc cttcaccagg ggttggggcc   2820 

ccttcccctg gagcccgtgg gtgcacctgt tactgttggg ctttccactg agatctactg   2880 

gataaagaat aaagttctat ttattct                                       2907 

 
           
             58  
             5026  
             DNA  
             human  
           
            58 

agaggaggaa attgttcctc gtctgataag acaacagtgg agaaaggacg catgctgttt     60 

cttagggaca cggctgactt ccagatatga ccatgtattt gtggcttaaa ctcttggcat    120 

ttggctttgc ctttctggac acagaagtat ttgtgacagg gcaaagccca acaccttccc    180 

ccactggatt gactacagca aagatgccca gtgttccact ttcaagtgac cccttaccta    240 

ctcacaccac tgcattctca cccgcaagca cctttgaaag agaaaatgac ttctcagaga    300 

ccacaacttc tcttagtcca gacaatactt ccacccaagt atccccggac tctttggata    360 

atgctagtgc ttttaatacc acaggtgttt catcagtaca gacgcctcac cttcccacgc    420 

acgcagactc gcagacgccc tctgctggaa ctgacacgca gacattcagc ggctccgccg    480 

ccaatgcaaa actcaaccct accccaggca gcaatgctat ctcagatgtc ccaggagaga    540 

ggagtacagc cagcaccttt cctacagacc cagtttcccc attgacaacc accctcagcc    600 

ttgcacacca cagctctgct gccttacctg cacgcacctc caacaccacc atcacagcga    660 

acacctcaga tgcctacctt aatgcctctg aaacaaccac tctgagccct tctggaagcg    720 

ctgtcatttc aaccacaaca atagctacta ctccatctaa gccaacatgt gatgaaaaat    780 

atgcaaacat cactgtggat tacttatata acaaggaaac taaattattt acagcaaagc    840 

taaatgttaa tgagaatgtg gaatgtggaa acaatacttg cacaaacaat gaggtgcata    900 

accttacaga atgtaaaaat gcgtctgttt ccatatctca taattcatgt actgctcctg    960 

ataagacatt aatattagat gtgccaccag gggttgaaaa gtttcagtta catgattgta   1020 

cacaagttga aaaagcagat actactattt gtttaaaatg gaaaaatatt gaaaccttta   1080 

cttgtgatac acagaatatt acctacagat ttcagtgtgg taatatgata tttgataata   1140 

aagaaattaa attagaaaac cttgaacccg aacatgagta taagtgtgac tcagaaatac   1200 

tctataataa ccacaagttt actaacgcaa gtaaaattat taaaacagat tttgggagtc   1260 

caggagagcc tcagattatt ttttgtagaa gtgaagctgc acatcaagga gtaattacct   1320 

ggaatccccc tcaaagatca tttcataatt ttaccctctg ttatataaaa gagacagaaa   1380 

aagattgcct caatctggat aaaaacctga tcaaatatga tttgcaaaat ttaaaacctt   1440 

atacgaaata tgttttatca ttacatgcct acatcattgc aaaagtgcaa cgtaatggaa   1500 

gtgctgcaat gtgtcatttc acaactaaaa gtgctcctcc aagccaggtc tggaacatga   1560 

ctgtctccat gacatcagat aatagtatgc atgtcaagtg taggcctccc agggaccgta   1620 

atggccccca tgaacgttac catttggaag ttgaagctgg aaatactctg gttagaaatg   1680 

agtcgcataa gaattgcgat ttccgtgtaa aagatcttca atattcaaca gactacactt   1740 

ttaaggccta ttttcacaat ggagactatc ctggagaacc ctttatttta catcattcaa   1800 

catcttataa ttctaaggca ctgatagcat ttctggcatt tctgattatt gtgacatcaa   1860 

tagccctgct tgttgttctc tacaaaatct atgatctaca taagaaaaga tcctgcaatt   1920 

tagatgaaca gcaggagctt gttgaaaggg atgatgaaaa acaactgatg aatgtggagc   1980 

caatccatgc agatattttg ttggaaactt ataagaggaa gattgctgat gaaggaagac   2040 

tttttctggc tgaatttcag agcatcccgc gggtgttcag caagtttcct ataaaggaag   2100 

ctcgaaagcc ctttaaccag aataaaaacc gttatgttga cattcttcct tatgattata   2160 

accgtgttga actctctgag ataaacggag atgcagggtc aaactacata aatgccagct   2220 

atattgatgg tttcaaagaa cccaggaaat acattgctgc acaaggtccc agggatgaaa   2280 

ctgttgatga tttctggagg atgatttggg aacagaaagc cacagttatt gtcatggtca   2340 

ctcgatgtga agaaggaaac aggaacaagt gtgcagaata ctggccgtca atggaagagg   2400 

gcactcgggc ttttggagat gttgttgtaa agatcaacca gcacaaaaga tgtccagatt   2460 

acatcattca gaaattgaac attgtaaata aaaaagaaaa agcaactgga agagaggtga   2520 

ctcacattca gttcaccagc tggccagacc acggggtgcc tgaggatcct cacttgctcc   2580 

tcaaactgag aaggagagtg aatgccttca gcaatttctt cagtggtccc attgtggtgc   2640 

actgcagtgc tggtgttggg cgcacaggaa cctatatcgg aattgatgcc atgctagaag   2700 

gcctggaagc cgagaacaaa gtggatgttt atggttatgt tgtcaagcta aggcgacaga   2760 

gatgcctgat ggttcaagta gaggcccagt acatcttgat ccatcaggct ttggtggaat   2820 

acaatcagtt tggagaaaca gaagtgaatt tgtctgaatt acatccatat ctacataaca   2880 

tgaagaaaag ggatccaccc agtgagccgt ctccactaga ggctgaattc cagagacttc   2940 

cttcatatag gagctggagg acacagcaca ttggaaatca agaagaaaat aaaagtaaaa   3000 

acaggaattc taatgtcatc ccatatgact ataacagagt gccacttaaa catgagctgg   3060 

aaatgagtaa agagagtgag catgattcag atgaatcctc tgatgatgac agtgattcag   3120 

aggaaccaag caaatacatc aatgcatctt ttataatgag ctactggaaa cctgaagtga   3180 

tgattgctgc tcagggacca ctgaaggaga ccattggtga cttttggcag atgatcttcc   3240 

aaagaaaagt caaagttatt gttatgctga cagaactgaa acatggagac caggaaatct   3300 

gtgctcagta ctggggagaa ggaaagcaaa catatggaga tattgaagtt gacctgaaag   3360 

acacagacaa atcttcaact tatacccttc gtgtctttga actgagacat tccaagagga   3420 

aagactctcg aactgtgtac cagtaccaat atacaaactg gagtgtggag cagcttcctg   3480 

cagaacccaa ggaattaatc tctatgattc aggtcgtcaa acaaaaactt ccccagaaga   3540 

attcctctga agggaacaag catcacaaga gtacacctct actcattcac tgcagggatg   3600 

gatctcagca aacgggaata ttttgtgctt tgttaaatct cttagaaagt gcggaaacag   3660 

aagaggtagt ggatattttt caagtggtaa aagctctacg caaagctagg ccaggcatgg   3720 

tttccacatt cgagcaatat caattcctat atgacgtcat tgccagcacc taccctgctc   3780 

agaatggaca agtaaagaaa aacaaccatc aagaagataa aattgaattt gataatgaag   3840 

tggacaaagt aaagcaggat gctaattgtg ttaatccact tggtgcccca gaaaagctcc   3900 

ctgaagcaaa ggaacaggct gaaggttctg aacccacgag tggcactgag gggccagaac   3960 

attctgtcaa tggtcctgca agtccagctt taaatcaagg ttcataggaa aagacataaa   4020 

tgaggaaact ccaaacctcc tgttagctgt tatttctatt tttgtagaag taggaagtga   4080 

aaataggtat acagtggatt aattaaatgc agcgaaccaa tatttgtaga agggttatat   4140 

tttactactg tggaaaaata tttaagatag ttttgccaga acagtttgta cagacgtatg   4200 

cttattttaa aattttatct cttattcagt aaaaaacaac ttctttgtaa tcgttatgtg   4260 

tgtatatgta tgtgtgtatg ggtgtgtgtt tgtgtgagag acagagaaag agagagaatt   4320 

ctttcaagtg aatctaaaag cttttgcttt tcctttgttt ttatgaagaa aaaatacatt   4380 

ttatattaga agtgttaact tagcttgaag gatctgtttt taaaaatcat aaactgtgtg   4440 

cagactcaat aaaatcatgt acatttctga aatgacctca agatgtcctc cttgttctac   4500 

tcatatatat ctatcttata tacttactat tttacttcta gagatagtac ataaaggtgg   4560 

tatgtgtgtg tatgctacta caaaaaagtt gttaactaaa ttaacattgg gaaatcttat   4620 

attccatata ttagcattta gtccaatgtc tttttaagct tatttaatta aaaaatttcc   4680 

agtgagctta tcatgctgtc tttacatggg gttttcaatt ttgcatgctc gattattccc   4740 

tgtacaatat ttaaaattta ttgcttgata cttttgacaa caaattaggt tttgtacaat   4800 

tgaacttaaa taaatgtcat taaaataaat aaatgcaata tgtattaata ttcattgtat   4860 

aaaaatagaa gaatacaaac atatttgtta aatatttaca tatgaaattt aatatagcta   4920 

tttttatgga atttttcatt gatatgaaaa atatgatatt gcatatgcat agttcccatg   4980 

ttaaatccca ttcataactt tcattaaagc atttactttg aatttc                  5026 

 
           
             59  
             625  
             DNA  
             human  
           
            59 

aggcgggccg ctcccacttc ggcacgaggg gcacgaggta aatcttttct gcttactgaa     60 

aaggaagagt ctgatgatta gttactgatc ctctttgcat ttgtaaagct ttggagatat    120 

tgaatcatgt taccatttct gtttttttcc accctgtttt cttccatatt tactgaagct    180 

cagaagcagt attgggtctg caactcatcc gatgcaagta tttcatacac ctactgtgat    240 

aaaatgcaat acccaatttc aattaatgtt aacccctgta tagaattgaa aggatccaaa    300 

ggattattgc acattttcta cattccaagg agagatttaa agcaattata tttcaatctc    360 

tatataactg tcaacaccat gaatcttcca aagcgcaaag aagttatttg ccgaggatct    420 

gatgacgatt actctttttg cagagctctg aagggagaga ctgtgaatac aacaatatca    480 

ttctccttca agggaataaa attttctaag ggaaaataca aatgtgttgt tgaagctatt    540 

tctgggagcc cagaagaaat gctcttttgc ttggagtttg tcatcctaca ccaacctaat    600 

tcaaattaga ataaattgag tattt                                          625 

 
           
             60  
             2088  
             DNA  
             human  
           
            60 

gaattcggca cgagcgcgcg gcgaatctca acgctgcgcc gtctgcgggc gcttccgggc     60 

caccagtttc tctgctttcc accctggcgc cccccagccc tggctcccca gctgcgctgc    120 

cccgggcgtc cacgccctgc gggcttagcg ggttcagtgg gctcaatctg cgcagcgcca    180 

cctccatgtt gaccaagcct ctacaggggc ctcccgcgcc ccccgggacc cccacgccgc    240 

cgccaggagg caaggatcgg gaagcgttcg aggccgagta tcgactcggc cccctcctgg    300 

gtaagggggg ctttggcacc gtcttcgcag gacaccgcct cacagatcga ctccaggtgg    360 

ccatcaaagt gattccccgg aatcgtgtgc tgggctggtc ccccttgtca gactcagtca    420 

catgcccact cgaagtcgca ctgctatgga aagtgggtgc aggtggtggg caccctggcg    480 

tgatccgcct gcttgactgg tttgagacac aggaaggctt catgctggtc ctcgagcggc    540 

ctttgcccgc ccaggatctc tttgactata tcacagagaa gggcccactg ggtgaaggcc    600 

caagccgctg cttctttggc caagtagtgg cagccatcca gcactgccat tcccgtggag    660 

ttgtccatcg tgacatcaag gatgagaaca tcctgataga cctacgccgt ggctgtgcca    720 

aactcattga ttttggttct ggtgccctgc ttcatgatga accctacact gactttgatg    780 

ggacaagggt gtacagcccc ccagagtgga tctctcgaca ccagtaccat gcactcccgg    840 

ccactgtctg gtcactgggc atcctcctct atgacatggt gtgtggggac attccctttg    900 

agagggacca ggagattctg gaagctgagc tccacttccc agcccatgtc tccccagact    960 

gctgtgccct aatccgccgg tgcctggccc ccaaaccttc ttcccgaccc tcactggaag   1020 

agatcctgct ggacccctgg atgcaaacac cagccgagga tgttacccct caacccctcc   1080 

aaaggaggcc ctgccccttt ggcctggtcc ttgctaccct aagcctggcc tggcctggcc   1140 

tggcccccaa tggtcagaag agccatccca tggccatgtc acagggatag atggacattt   1200 

gttgacttgg ttttacaggt cattaccagt cattaaagtc cagtattact aaggtaaggg   1260 

attgaggatc aggggttaga agacataaac caagtttgcc cagttccctt cccaatccta   1320 

caaaggagcc ttcctcccag aacctgtggt ccctgatttt ggagggggaa cttcttgctt   1380 

ctcattttgc taaggaagtt tattttggtg aagttgttcc cattttgagc cccgggactc   1440 

ttattttgat gatgtgtcac cccacattgg cacctcctac taccaccaca caaacttagt   1500 

tcatatgctt ttacttgggc aagggtgctt tccttccaat accccagtag cttttatttt   1560 

agtaaaggga ccctttcccc tagcctaggg tcccatattg ggtcaagctg cttacctgcc   1620 

tcagcccagg attttttatt ttgggggagg taatgccctg ttgttacccc aaggcttctt   1680 

tttttttttt tttttttttg ggtgagggga ccctactttg ttatcccaag tgctcttatt   1740 

ctggtgagaa gaaccttaat tccataattt gggaaggaat ggaagatgga caccaccgga   1800 

caccaccaga caataggatg ggatggatgg ttttttgggg gatgggctag gggaaataag   1860 

gcttgctgtt tgttttcctg gggcgctccc tccaattttg cagatttttg caacctcctc   1920 

ctgagccggg attgtccaat tactaaaatg taaataatca cgtattgtgg ggaggggagt   1980 

tccaagtgtg ccctcctttt ttttcctgcc tggattattt aaaaagccat gtgtggaaac   2040 

ccactattta ataaaagtaa tagaatcaga aaaaaaaaaa aaaaaaaa                2088 

 
           
             61  
             2270  
             DNA  
             human  
           
            61 

ctcctccagc ctctcacact ctcctcagct ctctcatctc ctggaaccat ggccagcaca     60 

tccaccacca tcaggagcca cagcagcagc cgccggggtt tcagtgccaa ctcagccagg    120 

ctccctgggg tcagccgctc tggcttcagc agcgtctccg tgtcccgctc caggggcagt    180 

ggtggcctgg gtggtgcatg tggaggagct ggctttggca gccgcagtct gtatggcctg    240 

gggggctcca agaggatctc cattggaggg ggcagctgtg ccatcagtgg cggctatggc    300 

agcagagccg gaggcagcta tggctttggt ggcgccggga gtggatttgg tttcggtggt    360 

ggagccggca ttggctttgg tctgggtggt ggagccggcc ttgctggtgg ctttgggggc    420 

cctggcttcc ctgtgtgccc ccctggaggc atccaagagg tcaccgtcaa ccagagtctc    480 

ctgactcccc tcaacctgca aatcgatccc accatccagc gggtgcgggc tgaggagcgt    540 

gaacagatca agaccctcaa caacaagttt gcctccttca tcgacaaggt gcggttcctg    600 

gagcagcaga acaaggttct ggaaacaaag tggaccctgc tgcaggagca gggcaccaag    660 

actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct caggaggcag    720 

ctggacagca ttgtcgggga acggggccgc ctggactcag agctcagagg catgcaggac    780 

ctggtggagg acttcaagaa caaatatgag gatgaaatca acaagcgcac agcagcagag    840 

aatgaatttg tgactctgaa gaaggatgtg gatgctgcct acatgaacaa ggttgaactg    900 

caagccaagg cagacactct cacagacgag atcaacttcc tgagagcctt gtatgatgca    960 

gagctgtccc agatgcagac ccacatctca gacacatctg tggtgctgtc catggacaac   1020 

aaccgcaacc tggacctgga cagcatcatc gctgaggtca aggcccaata tgaggagatt   1080 

gctcagagaa gccgggctga ggctgagtcc tggtaccaga ccaagtacga ggagctgcag   1140 

gtcacagcag gcagacatgg ggacgacctg cgcaacacca agcaggagat tgctgagatc   1200 

aaccgcatga tccagaggct gagatctgag atcgaccacg tcaagaagca gtgcgccaac   1260 

ctgcaggccg ccattgctga tgctgagcag cgtggggaga tggccctcaa ggatgccaag   1320 

aacaagctgg aagggctgga ggatgccctg cagaaggcca agcaggacct ggcccggctg   1380 

ctgaaggagt accaggagct gatgaatgtc aagctggccc tggacgtgga gatcgccacc   1440 

taccgcaagc tgctggaggg tgaggagtgc aggctgaatg gcgaaggcgt tggacaagtc   1500 

aacatctctg tggtgcagtc caccgtctcc agtggctatg gcggtgccag tggtgtcggc   1560 

agtggcttag gcctgggtgg aggaagcagc tactcctatg gcagtggtct tggcgttgga   1620 

ggtggcttca gttccagcag tggcagagcc attgggggtg gcctcagctc tgttggaggc   1680 

ggcagttcca ccatcaagta caccaccacc tcctcctcca gcaggaagag ctataagcac   1740 

taaagtgcgt ctgctagctc tcggtcccac agtcctcagg cccctctctg gctgcagagc   1800 

cctctcctca ggttgcctgt cctctcctgg cctccagtct cccctgctgt cccaggtaga   1860 

gctggggatg aatgcttagt gccctcactt cttctctctc tctctatacc atctgagcac   1920 

ccattgctca ccatcagatc aacctctgat tttacatcat gatgtaatca ccactggagc   1980 

ttcactgtta ctaaattatt aatttcttgc ctccagtgtt ctatctctga ggctgagcat   2040 

tataagaaaa tgacctctgc tccttttcat tgcagaaaat tgccaggggc ttatttcaga   2100 

acaacttcca cttactttcc actggctctc aaactctcta acttataagt gttgtgaacc   2160 

cccacccagg cagtatccat gaaagcacaa gtgactagtc ctatgatgta caaagcctgt   2220 

atctctgtga tgatttctgt gctcttcact gtttgcaatt gctaaataaa              2270 

 
           
             62  
             2048  
             DNA  
             human  
           
            62 

atgtgaaggc acaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa     60 

gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt    120 

tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat    180 

agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg    240 

tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg    300 

acatgaggca actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg    360 

tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc    420 

agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac    480 

caccagattt acatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac    540 

cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga    600 

gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg    660 

caaggtcaaa cctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt    720 

catcatgggc tgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga    780 

caaatttgag aaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac    840 

caaacccatc agtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga    900 

agttattggg catcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg    960 

gaccagcgtg gttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt   1020 

gctcttcact ggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga   1080 

tgtcccaaaa ctagtgactg agttcctggc aaagaaattt gacctggacc agttgataac   1140 

tcatgtttta ccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag   1200 

cattcgaacg gtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt   1260 

gaactggagt ttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat   1320 

acaagcataa gtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt   1380 

tataaacatt taaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt   1440 

ttgatttaca ttttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc   1500 

tatgttgaaa tggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa   1560 

cagatatagc gtataaagat atagtaaatg catctcccag agtaatattc acttaacaca   1620 

ttgaaactat tattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt   1680 

taacttggat tacattttga aatcagttca ttccatgatg catattactg gattagatta   1740 

agaaagacag aaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac   1800 

ataacttggt gaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata   1860 

tattaatatt ttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc   1920 

atattatcat acttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc   1980 

cctattcact gtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa   2040 

ctaaaccg                                                            2048 

 
           
             63  
             2048  
             DNA  
             human  
           
            63 

atgtgaaggc acaagctgct gttatataca acagagtgaa ctgagcatca gtcagaaaaa     60 

gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt    120 

tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat    180 

agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg    240 

tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg    300 

acatgaggca actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg    360 

tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc    420 

agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac    480 

caccagattt acatgcaagg gcaaaccagt acaccacttc atgaacacca gtacatttac    540 

cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga    600 

gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg    660 

caaggtcaaa cctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt    720 

catcatgggc tgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga    780 

caaatttgag aaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac    840 

caaacccatc agtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga    900 

agttattggg catcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg    960 

gaccagcgtg gttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt   1020 

gctcttcact ggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga   1080 

tgtcccaaaa ctagtgactg agttcctggc aaagaaattt gacctggacc agttgataac   1140 

tcatgtttta ccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag   1200 

cattcgaacg gtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt   1260 

gaactggagt ttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat   1320 

acaagcataa gtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt   1380 

tataaacatt taaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt   1440 

ttgatttaca ttttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc   1500 

tatgttgaaa tggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa   1560 

cagatatagc gtataaagat atagtaaatg catctcccag agtaatattc acttaacaca   1620 

ttgaaactat tattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt   1680 

taacttggat tacattttga aatcagttca ttccatgatg catattactg gattagatta   1740 

agaaagacag aaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac   1800 

ataacttggt gaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata   1860 

tattaatatt ttagaaaata ttccttttgt aatactgaat ataaacatag agctagagtc   1920 

atattatcat acttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc   1980 

cctattcact gtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa   2040 

ctaaaccg                                                            2048 

 
           
             64  
             2816  
             DNA  
             human  
           
            64 

tcgttgatat caaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct     60 

acagtactgc cctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg    120 

aaagaaagtt attaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt    180 

ccagaggttt tccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc    240 

attgacttga actttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt    300 

agcatggact gtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac    360 

acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc    420 

agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag    480 

cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac    540 

ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc    600 

tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc    660 

cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac    720 

aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt    780 

gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc    840 

catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag    900 

ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt    960 

tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat   1020 

gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac   1080 

aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt   1140 

gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag   1200 

aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat   1260 

gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca   1320 

attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc   1380 

ctttcagcct gcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct   1440 

gacgtcttct ttagacattc caagccccca aaccgatcag tgtacccata gagccctatc   1500 

tctatatttt aagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta   1560 

tgtgtgtgcg tgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga   1620 

cccaactgct caaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct   1680 

ttacaagaaa ggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag   1740 

gaaccactgt gtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg   1800 

gaaaggggca ttaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa   1860 

aattcacagg gaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag   1920 

aaaaaagttg ttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga   1980 

cccttttaat gctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg   2040 

tactgctggg cagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc   2100 

tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat   2160 

gctgtgtacc tgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta   2220 

catgaaaccc tggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa   2280 

ctcattttgt gcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt   2340 

tgtttaccat tattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt   2400 

aatttgctta attagagctt ctatccctca agcctaccta ccataaaacc agccatatta   2460 

ctgatactgt tcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc   2520 

agacgtgtta aaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt   2580 

ttcttttttt tactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt   2640 

ttaagataat agcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt   2700 

caccagcact gtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt   2760 

ttgtggatgt gtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa       2816 

 
           
             65  
             2816  
             DNA  
             human  
           
            65 

tcgttgatat caaagacagt tgaaggaaat gaattttgaa acttcacggt gtgccaccct     60 

acagtactgc cctgaccctt acatccagcg tttcgtagaa acccagctca tttctcttgg    120 

aaagaaagtt attaccgatc caccatgtcc cagagcacac agacaaatga attcctcagt    180 

ccagaggttt tccagcatat ctgggatttt ctggaacagc ctatatgttc agttcagccc    240 

attgacttga actttgtgga tgaaccatca gaagatggtg cgacaaacaa gattgagatt    300 

agcatggact gtatccgcat gcaggactcg gacctgagtg accccatgtg gccacagtac    360 

acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc    420 

agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag    480 

cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac    540 

ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc    600 

tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac atgccccatc    660 

cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat gcctgtctac    720 

aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt    780 

gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga ggggaacagc    840 

catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt accttatgag    900 

ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg taacagcagt    960 

tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga aaccagagat   1020 

gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac   1080 

aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt   1140 

gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac atccatcaag   1200 

aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg tgagacttat   1260 

gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc tcagcacaca   1320 

attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca gaaacatctc   1380 

ctttcagcct gcttcaggaa tgagcttgtg gagccccgga gagaaactcc aaaacaatct   1440 

gacgtcttct ttagacattc caagccccca aaccgatcag tgtacccata gagccctatc   1500 

tctatatttt aagtgtgtgt gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta   1560 

tgtgtgtgcg tgtgtatcta gccctcataa acaggacttg aagacacttt ggctcagaga   1620 

cccaactgct caaaggcaca aagccactag tgagagaatc ttttgaaggg actcaaacct   1680 

ttacaagaaa ggatgttttc tgcagatttt gtatccttag accggccatt ggtgggtgag   1740 

gaaccactgt gtttgtctgt gagctttctg ttgtttcctg ggagggaggg gtcaggtggg   1800 

gaaaggggca ttaagatgtt tattggaacc cttttctgtc ttcttctgtt gtttttctaa   1860 

aattcacagg gaagcttttg agcaggtctc aaacttaaga tgtcttttta agaaaaggag   1920 

aaaaaagttg ttattgtctg tgcataagta agttgtaggt gactgagaga ctcagtcaga   1980 

cccttttaat gctggtcatg taataatatt gcaagtagta agaaacgaag gtgtcaagtg   2040 

tactgctggg cagcgaggtg atcattacca aaagtaatca actttgtggg tggagagttc   2100 

tttgtgagaa cttgcattat ttgtgtcctc ccctcatgtg taggtagaac atttcttaat   2160 

gctgtgtacc tgcctctgcc actgtatgtt ggcatctgtt atgctaaagt ttttcttgta   2220 

catgaaaccc tggaagacct actacaaaaa aactgttgtt tggcccccat agcaggtgaa   2280 

ctcattttgt gcttttaata gaaagacaaa tccaccccag taatattgcc cttacgtagt   2340 

tgtttaccat tattcaaagc tcaaaataga atttgaagcc ctctcacaaa atctgtgatt   2400 

aatttgctta attagagctt ctatccctca agcctaccta ccataaaacc agccatatta   2460 

ctgatactgt tcagtgcatt tagccaggag acttacgttt tgagtaagtg agatccaagc   2520 

agacgtgtta aaatcagcac tcctggactg gaaattaaag attgaaaggg tagactactt   2580 

ttcttttttt tactcaaaag tttagagaat ctctgtttct ttccatttta aaaacatatt   2640 

ttaagataat agcataaaga ctttaaaaat gttcctcccc tccatcttcc cacacccagt   2700 

caccagcact gtattttctg tcaccaagac aatgatttct tgttattgag gctgttgctt   2760 

ttgtggatgt gtgattttaa ttttcaataa acttttgcat cttggtttaa aagaaa       2816 

 
           
             66  
             5838  
             DNA  
             human  
           
            66 

ccgggcaggt ggctcatgct cgggagcgtg gttgagcggc tggcgcggtt gtcctggagc     60 

aggggcgcag gaattctgat gtgaaactaa cagtctgtga gccctggaac ctccgctcag    120 

agaagatgaa ggatatcgac ataggaaaag agtatatcat ccccagtcct gggtatagaa    180 

gtgtgaggga gagaaccagc acttctggga cgcacagaga ccgtgaagat tccaagttca    240 

ggagaactcg accgttggaa tgccaagatg ccttggaaac agcagcccga gccgagggcc    300 

tctctcttga tgcctccatg cattctcagc tcagaatcct ggatgaggag catcccaagg    360 

gaaagtacca tcatggcttg agtgctctga agcccatccg gactacttcc aaacaccagc    420 

acccagtgga caatgctggg cttttttcct gtatgacttt ttcgtggctt tcttctctgg    480 

cccgtgtggc ccacaagaag ggggagctct caatggaaga cgtgtggtct ctgtccaagc    540 

acgagtcttc tgacgtgaac tgcagaagac tagagagact gtggcaagaa gagctgaatg    600 

aagttgggcc agacgctgct tccctgcgaa gggttgtgtg gatcttctgc cgcaccaggc    660 

tcatcctgtc catcgtgtgc ctgatgatca cgcagctggc tggcttcagt ggaccagcct    720 

tcatggtgaa acacctcttg gagtataccc aggcaacaga gtctaacctg cagtacagct    780 

tgttgttagt gctgggcctc ctcctgacgg aaatcgtgcg gtcttggtcg cttgcactga    840 

cttgggcatt gaattaccga accggtgtcc gcttgcgggg ggccatccta accatggcat    900 

ttaagaagat ccttaagtta aagaacatta aagagaaatc cctgggtgag ctcatcaaca    960 

tttgctccaa cgatgggcag agaatgtttg aggcagcagc cgttggcagc ctgctggctg   1020 

gaggacccgt tgttgccatc ttaggcatga tttataatgt aattattctg ggaccaacag   1080 

gcttcctggg atcagctgtt tttatcctct tttacccagc aatgatgttt gcatcacggc   1140 

tcacagcata tttcaggaga aaatgcgtgg ccgccacgga tgaacgtgtc cagaagatga   1200 

atgaagttct tacttacatt aaatttatca aaatgtatgc ctgggtcaaa gcattttctc   1260 

agagtgttca aaaaatccgc gaggaggagc gtcggatatt ggaaaaagcc gggtacttcc   1320 

agggtatcac tgtgggtgtg gctcccattg tggtggtgat tgccagcgtg gtgaccttct   1380 

ctgttcatat gaccctgggc ttcgatctga cagcagcaca ggctttcaca gtggtgacag   1440 

tcttcaattc catgactttt gctttgaaag taacaccgtt ttcagtaaag tccctctcag   1500 

aagcctcagt ggctgttgac agatttaaga gtttgtttct aatggaagag gttcacatga   1560 

taaagaacaa accagccagt cctcacatca agatagagat gaaaaatgcc accttggcat   1620 

gggactcctc ccactccagt atccagaact cgcccaagct gacccccaaa atgaaaaaag   1680 

acaagagggc ttccaggggc aagaaagaga aggtgaggca gctgcagcgc actgagcatc   1740 

aggcggtgct ggcagagcag aaaggccacc tcctcctgga cagtgacgag cggcccagtc   1800 

ccgaagagga agaaggcaag cacatccacc tgggccacct gcgcttacag aggacactgc   1860 

acagcatcga tctggagatc caagagggta aactggttgg aatctgcggc agtgtgggaa   1920 

gtggaaaaac ctctctcatt tcagccattt taggccagat gacgcttcta gagggcagca   1980 

ttgcaatcag tggaaccttc gcttatgtgg cccagcaggc ctggatcctc aatgctactc   2040 

tgagagacaa catcctgttt gggaaggaat atgatgaaga aagatacaac tctgtgctga   2100 

acagctgctg cctgaggcct gacctggcca ttcttcccag cagcgacctg acggagattg   2160 

gagagcgagg agccaacctg agcggtgggc agcgccagag gatcagcctt gcccgggcct   2220 

tgtatagtga caggagcatc tacatcctgg acgaccccct cagtgcctta gatgcccatg   2280 

tgggcaacca catcttcaat agtgctatcc ggaaacatct caagtccaag acagttctgt   2340 

ttgttaccca ccagttacag tacctggttg actgtgatga agtgatcttc atgaaagagg   2400 

gctgtattac ggaaagaggc acccatgagg aactgatgaa tttaaatggt gactatgcta   2460 

ccatttttaa taacctgttg ctgggagaga caccgccagt tgagatcaat tcaaaaaagg   2520 

aaaccagtgg ttcacagaag aagtcacaag acaagggtcc taaaacagga tcagtaaaga   2580 

aggaaaaagc agtaaagcca gaggaagggc agcttgtgca gctggaagag aaagggcagg   2640 

gttcagtgcc ctggtcagta tatggtgtct acatccaggc tgctgggggc cccttggcat   2700 

tcctggttat tatggccctt ttcatgctga atgtaggcag caccgccttc agcacctggt   2760 

ggttgagtta ctggatcaag caaggaagcg ggaacaccac tgtgactcga gggaacgaga   2820 

cctcggtgag tgacagcatg aaggacaatc ctcatatgca gtactatgcc agcatctacg   2880 

ccctctccat ggcagtcatg ctgatcctga aagccattcg aggagttgtc tttgtcaagg   2940 

gcacgctgcg agcttcctcc cggctgcatg acgagctttt ccgaaggatc cttcgaagcc   3000 

ctatgaagtt ttttgacacg acccccacag ggaggattct caacaggttt tccaaagaca   3060 

tggatgaagt tgacgtgcgg ctgccgttcc aggccgagat gttcatccag aacgttatcc   3120 

tggtgttctt ctgtgtggga atgatcgcag gagtcttccc gtggttcctt gtggcagtgg   3180 

ggccccttgt catcctcttt tcagtcctgc acattgtctc cagggtcctg attcgggagc   3240 

tgaagcgtct ggacaatatc acgcagtcac ctttcctctc ccacatcacg tccagcatac   3300 

agggccttgc caccatccac gcctacaata aagggcagga gtttctgcac agataccagg   3360 

agctgctgga tgacaaccaa gctccttttt ttttgtttac gtgtgcgatg cggtggctgg   3420 

ctgtgcggct ggacctcatc agcatcgccc tcatcaccac cacggggctg atgatcgttc   3480 

ttatgcacgg gcagattccc ccagcctatg cgggtctcgc catctcttat gctgtccagt   3540 

taacggggct gttccagttt acggtcagac tggcatctga gacagaagct cgattcacct   3600 

cggtggagag gatcaatcac tacattaaga ctctgtcctt ggaagcacct gccagaatta   3660 

agaacaaggc tccctcccct gactggcccc aggagggaga ggtgaccttt gagaacgcag   3720 

agatgaggta ccgagaaaac ctccctcttg tcctaaagaa agtatccttc acgatcaaac   3780 

ctaaagagaa gattggcatt gtggggcgga caggatcagg gaagtcctcg ctggggatgg   3840 

ccctcttccg tctggtggag ttatctggag gctgcatcaa gattgatgga gtgagaatca   3900 

gtgatattgg ccttgccgac ctccgaagca aactctctat cattcctcaa gagccggtgc   3960 

tgttcagtgg cactgtcaga tcaaatttgg accccttcaa ccagtacact gaagaccaga   4020 

tttgggatgc cctggagagg acacacatga aagaatgtat tgctcagcta cctctgaaac   4080 

ttgaatctga agtgatggag aatggggata acttctcagt gggggaacgg cagctcttgt   4140 

gcatagctag agccctgctc cgccactgta agattctgat tttagatgaa gccacagctg   4200 

ccatggacac agagacagac ttattgattc aagagaccat ccgagaagca tttgcagact   4260 

gtaccatgct gaccattgcc catcgcctgc acacggttct aggctccgat aggattatgg   4320 

tgctggccca gggacaggtg gtggagtttg acaccccatc ggtccttctg tccaacgaca   4380 

gttcccgatt ctatgccatg tttgctgctg cagagaacaa ggtcgctgtc aagggctgac   4440 

tcctccctgt tgacgaagtc tcttttcttt agagcattgc cattccctgc ctggggcggg   4500 

cccctcatcg cgtcctccta ccgaaacctt gcctttctcg attttatctt tcgcacagca   4560 

gttccggatt ggcttgtgtg tttcactttt agggagagtc atattttgat tattgtattt   4620 

attccatatt catgtaaaca aaatttagtt tttgttctta attgcactct aaaaggttca   4680 

gggaaccgtt attataattg tatcagaggc ctataatgaa gctttatacg tgtagctata   4740 

tctatatata attctgtaca tagcctatat ttacagtgaa aatgtaagct gtttatttta   4800 

tattaaaata agcactgtgc taataacagt gcatattcct ttctatcatt tttgtacagt   4860 

ttgctgtact agagatctgg ttttgctatt agactgtagg aagagtagca tttcattctt   4920 

ctctagctgg tggtttcacg gtgccaggtt ttctgggtgt ccaaaggaag acgtgtggca   4980 

atagtgggcc ctccgacagc cccctctgcc gcctccccac agccgctcca ggggtggctg   5040 

gagacgggtg ggcggctgga gaccatgcag agcgccgtga gttctcaggg ctcctgcctt   5100 

ctgtcctggt gtcacttact gtttctgtca ggagagcagc ggggcgaagc ccaggcccct   5160 

tttcactccc tccatcaaga atggggatca cagagacatt cctccgagcc ggggagtttc   5220 

tttcctgcct tcttcttttt gctgttgttt ctaaacaaga atcagtctat ccacagagag   5280 

tcccactgcc tcaggttcct atggctggcc actgcacaga gctctccagc tccaagacct   5340 

gttggttcca agccctggag ccaactgctg ctttttgagg tggcactttt tcatttgcct   5400 

attcccacac ctccacagtt cagtggcagg gctcaggatt tcgtgggtct gttttccttt   5460 

ctcaccgcag tcgtcgcaca gtctctctct ctctctcccc tcaaagtctg caactttaag   5520 

cagctcttgc taatcagtgt ctcacactgg cgtagaagtt tttgtactgt aaagagacct   5580 

acctcaggtt gctggttgct gtgtggtttg gtgtgttccc gcaaaccccc tttgtgctgt   5640 

ggggctggta gctcaggtgg gcgtggtcac tgctgtcatc agttgaatgg tcagcgttgc   5700 

atgtcgtgac caactagaca ttctgtcgcc ttagcatgtt tgctgaacac cttgtggaag   5760 

caaaaatctg aaaatgtgaa taaaattatt ttggattttg taaaaaaaaa aaaaaaaaaa   5820 

aaaaaaaaaa aaaaaaaa                                                 5838 

 
           
             67  
             6841  
             DNA  
             human  
           
            67 

gccggagggc gcccgagggg ccccgggccg cggcgctcag ggcccgggcg gccggcggcg     60 

gccccggggc tggggggagt ccagcccgga tattgagtgc agccattgag aaaagccaaa    120 

ctcttgtgtg tgcgcgtctc gatagccccc aagatggccg ccaatgtggg atcgatgttt    180 

caatattgga agcgatttga tctacggcga ctccagaagg agcttaattc cgtcgcttct    240 

gagctgtctg cacggcagga ggagagtgaa cattctcata aacatttaat tgaactccgc    300 

cgggaattta agaaaaatgt acctgaggaa atcagagaga tggtggctcc tgtattaaaa    360 

agcttccaag ccgaggtggt ggcccttagt aagagaagtc aggaggcgga ggctgctttt    420 

ctgagtgttt acaagcaatt aattgaagca ccagaccccg tgcctgtgtt tgaggcggca    480 

cgcagcctag acgacagact gcagcccccc agctttgacc ccagtgggca gccccggcga    540 

gacctccaca cttcgtggaa gaggaacccc gagctcctca gccccaaaga gcagagagag    600 

gggacgtcgc ctgccgggcc cacgctgacc gagggaagcc gcctcccagg cattcccggg    660 

aaagccctcc tgacagaaac cttgctgcag agaaatgagg cggaaaaaca aaagggcctt    720 

caagaagtac agatcacttt ggcggccaga ctgggggagg cagaggagaa aatcaaagtc    780 

ctacattcag cgctaaaggc tacgcaggca gagctgctag agctgcggcg gaagtacgac    840 

gaggaggcag catccaaggc agatgaagtc ggcctgatca tgaccaacct ggagaaagct    900 

aatcagcgag ctgaggctgc ccagcgggag gtggaaagtc tccgggaaca gctggcctct    960 

gtcaacagct ccatccgcct ggcttgctgc tctccccagg ggcccagtgg ggataaggtg   1020 

aacttcactc tgtgctcggg ccctcggctg gaggccgcgc tggcctccaa ggacagggag   1080 

atcctgcggc tgctgaagga cgtgcagcac ctccagagct cactgcagga gctggaggag   1140 

gcatccgcca accagatcgc cgacctggag cggcagctca cggccaagtc cgaggccata   1200 

gaaaagctgg aagagaagct ccaggcccag tctgactatg aggaaattaa aacggagctg   1260 

agcatcctga aagccatgaa gctggcctcc agcacctgca gcctccccca gggcatggcc   1320 

aagcctgaag actcactgct tattgcaaag gaggccttct tccccacgca gaaattcctt   1380 

ctggagaagc ccagcctcct ggccagccct gaggaagacc catcagagga cgattccatc   1440 

aaggattcac tgggcacgga gcagtcctac ccctcccctc agcagctccc acctccacca   1500 

gggccagaag accccctgtc tcccagcccc gggcagcccc tgctgggccc cagcttgggg   1560 

cctgacggca ctcggacttt ctcgctgtcc cccttcccca gcctggcatc aggggagaga   1620 

ctgatgatgc ccccagccgc cttcaaggga gaggcgggcg gcctgctggt gttcccccca   1680 

gccttctatg gcgccaagcc ccccacagcc cctgccaccc cggcccctgg ccctgagcca   1740 

ctgggcggtc ctgagcccgc ggatggtggt gggggcggag cggcggggcc cggggcagag   1800 

gaggagcagc tggacacggc agagatcgcc ttccaggtga aggagcagct gctgaaacac   1860 

aacatcgggc agcgggtgtt tgggcattac gtgctggggc tgtcgcaggg ctcggtcagc   1920 

gagatcctag cccggcccaa gccctggcgc aagctcacgg tgaagggcaa ggagcccttc   1980 

atcaagatga agcagttcct gtcggatgag cagaatgtac tggcgctcag gaccatccaa   2040 

gtgcggcagc gaggcagcat caccccgaga atccgcacgc ctgagacagg ctcagacgac   2100 

gccatcaaga gcattctaga gcaggccaag aaggagatcg agtcgcagaa gggcggcgag   2160 

cccaagacct cggtggcccc gctgagcatc gccaacggca cgacccccgc cagcacctcg   2220 

gaggacgcca tcaagagcat cctggagcag gcacgccgtg agatgcaggc gcaacagcag   2280 

gcgctgctgg agatggaggt ggcgcccagg ggccgctcgg tgcccccctc gcccccggag   2340 

cggccatcac tggccaccgc gagccagaac ggggccccgg ccttggtgaa gcaggaggag   2400 

ggcagcgggg gccccgcgca ggcgccgctc ccggtcctgt cccccgccgc cttcgtgcag   2460 

agcatcatcc gcaaggtcaa gtccgagatc ggcgacgccg gctacttcga ccaccactgg   2520 

gcctccgacc gcggcctgct cagccgcccc tacgcctccg tgtcgccctc gctgtcctcc   2580 

tcctcctcct ctggctactc tggccagccc aacggccgcg cctggccccg cggggacgag   2640 

gcccctgtgc cccccgagga cgaggcggcg gcaggggcgg aggacgaacc ccccaggacg   2700 

ggcgagctca aggctgaggg cgcgacggcc gaggcgggcg cgcggctgcc ctactacccg   2760 

gcctacgtgc cgcgcaccct gaagcccacc gtgccgccgc tgacccccga gcagtacgag   2820 

ctgtacatgt accgtgaggt agacacgctg gagctcaccc gccaggtcaa ggagaagctg   2880 

gccaagaacg gcatctgcca gaggatcttc ggggagaagg tgctgggcct gtcacagggc   2940 

agcgtgagcg acatgctgtc ccggccgaag ccatggagca agctgacgca gaaggggcgg   3000 

gagcccttca tccgcatgca gctgtggctc tctgaccagc tcggccaggc agtgggccag   3060 

cagcctggtg cctcccaggc cagtcccaca gaaccaaggt cctcaccatc cccacccccc   3120 

agccccacag agcctgagaa gagctcccag gagccgttga gcctgtccct ggagagcagc   3180 

aaggagaacc agcagccaga gggccgctcc agctcctcgt tgagcgggaa gatgtactca   3240 

ggcagccagg ccccaggggg catccaggag atcgtggcca tgtcccccga gctggacacg   3300 

tactccatca ccaagagggt gaaggaggtc ctcacagaca acaatctagg gcagcggctg   3360 

tttggggaaa gcatcctggg tctgacacag ggctccgtgt ctgacctgct gtcccggccc   3420 

aaaccctggc acaagctgag cctgaagggg cgggagcctt ttgtccgcat gcagctgtgg   3480 

ctcaatgacc cccataacgt ggagaagctg agggatatga agaagctgga gaagaaagcc   3540 

tacctgaaac gtcgctatgg cctcatcagc accggctcag acagtgagtc cccggccacc   3600 

cgctcagagt gccccagccc ctgcctgcag ccccaggacc tgagcctcct gcagatcaag   3660 

aagccccggg tggtgctggc acccgaggag aaggaggcac tgcggaaggc ctatcagctg   3720 

gaaccctacc cctcgcagca gaccatcgag ctcctctcct tccagctcaa cctcaagacc   3780 

aacaccgtca tcaactggtt ccacaactac aggtcccgga tgcgccggga gatgttggtg   3840 

gaggggaccc aggatgagcc agaccttgat ccaagcgggg gtcctggaat cctaccgcca   3900 

ggccactccc acccagaccc caccccgcag agccctgact ctgagactga ggaccagaag   3960 

ccaaccgtga aggaactgga gcttcaggag ggccctgagg agaacagcac acccctgacc   4020 

acccaggaca aggcccaagt gaggatcaag caggaacaga tggaggagga tgctgaggaa   4080 

gaggcaggca gccagcccca ggactcaggg gagctggaca aaggccaagg tccccccaaa   4140 

gaggagcatc ccgaccctcc gggtaatgat ggactcccaa aagtggctcc cgggcccctc   4200 

cttccaggtg gatccacccc agactgtccc tcacttcatc cccaacagga gagtgaggcc   4260 

ggggagcgac ttcacccgga ccctttaagt tttaagtcag cctcagagtc ctcacgctgc   4320 

agcctggagg tgtcactgaa ctcgccctcg gccgcctcct caccaggcct catgatgtct   4380 

gtgtcacctg tcccctcctc ctcagctccc atctccccat ccccacctgg cgccccccct   4440 

gccaaagtgc cgagtgccag ccccactgct gacatggctg gagccttgca ccccagtgcc   4500 

aaggtgaacc ccaacttgca gcggcggcat gagaagatgg ccaatctgaa caacatcatt   4560 

taccgactag agcgggctgc caatcgggag gaggccctgg agtgggagtt ctgaaggcag   4620 

ggtgaggggg caagggacat accctggtaa ctaccttcct tctcgcactt actctcctca   4680 

acaggatggg gtaagggagg gaggaactca accatcaaaa tgtggacagc aatgttatgc   4740 

cgtttacgtt ttttgttgta atcctagttc tatgaagctg tgtgagcagg tgggtcaaat   4800 

gccattgcct ccacttttct gcacccccct gctcctcttc accctgaccc ctctgcagga   4860 

ggcagaagca aaatggcacc acatattcac ctgaaaactc caaactcttt tagaaaaata   4920 

aataaatatt tatagacctc ttttagatat tttaataaag gatcctttgg aatttatccc   4980 

agctgatgct gttttgatat tacagagagt tataaaatca ggatgctgtc acaactgttg   5040 

cgaagtatac actgaagttg tgtcgttttt gccactagat gagattaaaa gaagacaatt   5100 

attcaaagcc atcacaaaac actataagac tgaccaaaat ttagataacc tttgaaccac   5160 

gatttttttc cacatctgtc tgtgagacac agcgcaatgc tactgccctt ccagaaactg   5220 

tgctaaaaag agaaagtcca aaagactcta aacaaaaacc tcgacgccgt tgaggatgtg   5280 

tttcattctg gtggtctgtt ttgcaagctt gataacagaa tgtccgtgcc attgtaaatg   5340 

ttgtagagat gtgggccgtg gcccaaccgt cctatatgag atgtagcatg gtacagaaca   5400 

aactgcttac acaggtctca ctagttagaa acctgtgggc catggaggtc agacatccat   5460 

cttgtccatc tataggcaag aagtgtttcc agatcctttg gaaaggtggg catggggcag   5520 

gtgcttggag agtggcgttt gagccagagc gaccccattt cccgtgtgaa ccataggcac   5580 

aacccaggaa gtttccccac ttgtaggagt gtgggtattc cagagcaaga ctgtggccac   5640 

catcttcccc tcttggtgtt ttccgaaagt gacagtgttg gtcatcccat gaccactgaa   5700 

gcttagtaac cagcgccaaa aagtagattc atcaaactag agaccccagc tccccttctc   5760 

gccatcttct ttctcaagtt gaccgtggtg ctgtttctgg aaggcatctg caactccaag   5820 

tccatgcaga actctggaag gccaagttca tcgcagcatg ttcaccatat cccagcctcc   5880 

aaatctatcc tcctaccttc caacgcatga cctgttgggg agcagagact taacccccaa   5940 

ctcagaggaa cccttcctcc agcgtctttg gcatggtttc tagggtgaga gttcccaatt   6000 

tggatagaac ggccaccata ttggttactg aatctctctc ccttgttttt attacgtttc   6060 

ctttttcaaa ctgtccatgg gaaggctgaa ttgagtgact ccccagaatg aagatgagaa   6120 

ggtgaatata atcaatgcca atgtaatgcc agcgggtgag atggccgatg gaggtttcaa   6180 

agatgtagct agcattttga aaccatatgg gcaaaacccg gcaaccagaa ggggacagat   6240 

aaggaccgtt ccagaaatcc caactctcac acccagccca ggctgcagtc tccacaccaa   6300 

acagtcaaca aaacacaaac cctgaaggaa aaccttttcc atacacccag gctatgcatt   6360 

gaagagtttt ccactgtata catttttatc cagatgaagg tatttttata ttttgacaat   6420 

aggaaacagt gaccattttc agagtaatca aatctggaac aaatgaaaca tcttttagcc   6480 

accaccaccc tgttgcaatt aagacaaccg tgggggaaca caccactttt tactgttgaa   6540 

accaacacaa cgttgaaatc caggcttata cgcagactcc gattcctaga gaactaaatt   6600 

tggctttagt gtgacgggat ttgattaagc acttagtata gtcttttgaa cacggaaatc   6660 

ctgttgtact taaagctagc ggacccgtga acaactttgt caggttcacg tcctataacg   6720 

gttaaaaaac acacacacac atacacaaac cgtttctatg agagattgat gaactttgtt   6780 

taaaatttta aaaaaaggaa cacgttctgt aaacgagtcg ctaaatacag aattgtataa   6840 

t                                                                   6841 

 
           
             68  
             1181  
             DNA  
             human  
           
            68 

ggcacgaggc ccgggccccc caaagtcccg gccgggccga gggtcggcgg ccgccggcgg     60 

gccgggcccg cgcacagcgc ccgcatgtac aacatgatgg agacggagct gaagccgccg    120 

ggcccgcagc aaacttcggg gggcggcggc ggcaactcca ccgcggcggc ggccggcggc    180 

aaccagaaaa acagcccgga ccgcgtcaag cggcccatga atgccttcat ggtgtggtcc    240 

cgcgggcagc ggcgcaagat ggcccaggag aaccccaaga tgcacaactc ggagatcagc    300 

aagcgcctgg gcgccgagtg gaaacttttg tcggagacgg agaagcggcc gttcatcgac    360 

gaggctaagc ggctgcgagc gctgcacatg aaggagcacc cggattataa ataccggccc    420 

cggcggaaaa ccaagacgct catgaagaag gataagtaca cgctgcccgg cgggctgctg    480 

gcccccggcg gcaatagcat ggcgagcggg gtcggggtgg gcgccggcct gggcgcgggc    540 

gtgaaccagc gcatggacag ttacgcgcac atgaacggct ggagcaacgg cagctacagc    600 

atgatgcagg accagctggg ctacccgcag cacccgggcc tcaatgcgca cggcgcagcg    660 

cagatgcagc ccatgcaccg ctacgacgtg agcgccctgc agtacaactc catgaccagc    720 

tcgcagacct acatgaacgg ctcgcccacc tacagcatgt cctactcgca gcagggcacc    780 

cctggcatgg ctcttggctc catgggttcg gtggtcaagt ccgaggccag ctccagcccc    840 

cctgtggtta cctcttcctc ccactccagg gcgccctgcc aggccgggga cctccgggac    900 

atgatcagca tgtatctccc cggcgccgag gtgccggaac ccgccgcccc cagcagactt    960 

cacatgtccc agcactacca gagcggcccg gtgcccggca cggccattaa cggcacactg   1020 

cccctctcac acatgtgagg gccggacagc gaactggagg ggggagaaat tttcaaagaa   1080 

aaacgaggga aatgggaggg gtgcaaaaga ggagagtaag aaacagcatg gagaaaaccc   1140 

ggtacgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1181 

 
           
             69  
             4755  
             DNA  
             human  
           
            69 

gctgctctcg ttcgcttggc tcagctcagc tcagctcagc gcagctccgc ggccgccaag     60 

ccgaggcggg cacggtctcc gagtcgcgga cgccagctcc gagctccctc tctccgccgc    120 

gcctccgcca ggtcgcgcct tcgtcgggac cacttcgggc aggagtcgcg tggcgaaggc    180 

ctgcggccgc ggcacaaagt tgggggccgc gaagatgagg ctgtccccgg cgcccctgaa    240 

gctgagccgg actccggcac tgctggccct ggcgctgccc ctggccgcgg cgctggcctt    300 

ctccgacgag accctggaca aagtgcccaa gtcagagggc tactgcagcc gtatcctgcg    360 

cgcccagggc acgcggcgcg agggctacac cgagttcagc ctccgcgtgg agggcgaccc    420 

cgacttctac aagccgggaa ccagctaccg cgtaacactt tcagctgctc ctccctccta    480 

cttcagagga ttcacattaa ttgccctcag agagaacaga gagggtgata aggaagaaga    540 

ccatgctggg accttccaga tcatagacga agaagaaact cagtttatga gcaattgccc    600 

tgttgcagtc actgaaagca ctccacggag gaggacccgg atccaggtgt tttggatagc    660 

accaccagcg ggaacaggct gcgtgattct gaaggccagc atcgtacaaa aacgcattat    720 

ttattttcaa gatgagggct ctctgaccaa gaaactttgt gaacaagatt ccacatttga    780 

tggggtgact gacaaaccca tcttagactg ctgtgcctgc ggaactgcca agtacagact    840 

cacattttat gggaattggt ccgagaagac acacccaaag gattaccctc gtcgggccaa    900 

ccactggtct gcgatcatcg gaggatccca ctccaagaat tatgtactgt gggaatatgg    960 

aggatatgcc agcgaaggcg tcaaacaagt tgcagaattg ggctcacccg tgaaaatgga   1020 

ggaagaaatt cgacaacaga gtgatgaggt cctcaccgtc atcaaagcca aagcccagtg   1080 

gccagcctgg cagcctctca acgtgagagc agcaccttca gctgaatttt ccgtggacag   1140 

aacgcgccat ttaatgtcct tcctgaccat gatgggccct agtcccgact ggaacgtagg   1200 

cttatctgca gaagatctgt gcaccaagga atgtggctgg gtccagaagg tggtgcaaga   1260 

cctgattccc tgggacgctg gcaccgacag cggggtgacc tatgagtcac ccaacaaacc   1320 

caccattccc caggagaaaa tccggcccct gaccagcctg gaccatcctc agagtccttt   1380 

ctatgaccca gagggtgggt ccatcactca agtagccaga gttgtcatcg agagaatcgc   1440 

acggaagggt gaacaatgca atattgtacc tgacaatgtc gatgatattg tagctgacct   1500 

ggctccagaa gagaaagatg aagatgacac ccctgaaacc tgcatctact ccaactggtc   1560 

cccatggtcc gcctgcagct cctccacctg tgacaaaggc aagaggatgc gacagcgcat   1620 

gctgaaagca cagctggacc tcagcgtccc ctgccctgac acccaggact tccagccctg   1680 

catgggccct ggctgcagtg acgaagacgg ccccacctgc accatgtccg agtggatcac   1740 

ctggtcgccc tgcagcatct cctgcggcat gggcatgagg tcccgggaga ggtatgtgaa   1800 

gcagttcccg gaggacggct ccgtgtgcac gctgcccact gaggaaacgg agaagtgcac   1860 

ggtcaacgag gagtgctctc ccagcagctg cctgatgacc gagtggggcg agtgggacga   1920 

gtacagcgcc acctgcggca tgggcatgaa gaagcggcac cgcatgatca agatgaaccc   1980 

cgcagatggc tccatgtgca aagccgagac atcacaggca gagaagcgca tgatgccaga   2040 

gtgccacacc atcccatgct tgctgtcccc atggtccgag tggagtgact gcagcgtgac   2100 

ctgcgggaag ggcatgcgaa cccgacagcg gatgctcaag tctctggcag aacttggaga   2160 

ctgcaatgag gatctggagc aggtggagaa gtgcatgctc cctgaatgcc ccattgactg   2220 

tgagctcacc gagtggtccc agtggtcgga atgtaacaag tcatgtggga aaggccacgt   2280 

gattcgaacc cggatgatcc aaatggagcc tcagtttgga ggtgcaccct gcccagagac   2340 

tgtgcagcga aaaaagtgcc gcatccgaaa atgccttcga aatccatcca tccaaaagct   2400 

acgctggagg gaggcccgag agagccggcg gagtgagcag ctgaaggaag agtctgaagg   2460 

ggagcagttc ccaggttgta ggatgcgccc atggacggcc tggtcagaat gcaccaaact   2520 

gtgcggaggt ggaattcagg aacgttacat gactgtaaag aagagattca aaagctccca   2580 

gtttaccagc tgcaaagaca agaaggagat cagagcatgc aatgttcatc cttgttagca   2640 

agggtacgag ttccccaggg ctgcactcta gattccagag tcaccaatgg ctggattatt   2700 

tgcttgttta agacaattta aattgtgtac gctagttttc atttttgcag tgtggttcgc   2760 

ccagtagtct tgtggatgcc agagacatcc tttctgaata cttcttgatg ggtacaggct   2820 

gagtggggcg ccctcacctc cagccagcct cttcctgcag aggagtagtg tcagccacct   2880 

tgtactaagc tgaaacatgt ccctctggag cttccacctg gccagggagg acggagactt   2940 

tgacctactc cacatggaga ggcaaccatg tctggaagtg actatgcctg agtcccaggg   3000 

tgcggcaggt aggaaacatt cacagatgaa gacagcagat tccccacatt ctcatctttg   3060 

gcctgttcaa tgaaaccatt gtttgcccat ctcttcttag tggaacttta ggtctctttt   3120 

caagtctcct cagtcatcaa tagttcctgg ggaaaaacag agctggtaga cttgaagagg   3180 

agcattgatg ttgggtggct tttgttcttt cactgagaaa ttcggaatac atttgtctca   3240 

cccctgatat tggttcctga tgccccccca acaaaaataa ataaataaat tatggctgct   3300 

ttatttaaat ataaggtagc tagtttttac acctgagata aataataagc ttagagtgta   3360 

tttttccctt gcttttgggg gttcagagga gtatgtacaa ttcttctggg aagccagcct   3420 

tctgaacttt ttggtactaa atccttattg gaaccaagac aaaggaagca aaattggtct   3480 

ctttagagac caatttgcct aaattttaaa atcttcctac acacatctag acgttcaagt   3540 

ttgcaaatca gtttttagca agaaaacatt tttgctatac aaacattttg ctaagtctgc   3600 

ccaaagcccc cccaatgcat tccttcaaca aaatacaatc tctgtacttt aaagttattt   3660 

tagtcatgaa attttatatg cagagagaaa aagttaccga gacagaaaac aaatctaagg   3720 

gaaaggaata ttatgggatt aagctgagca agcaattctg gtggaaagtc aaacctgtca   3780 

gtgctccaca ccagggctgt ggtcctccca gacatgcata ggaatggcca caggtttaca   3840 

ctgccttccc agcaattata agcacaccag attcagggag actgaccacc aagggatagt   3900 

gtaaaaggac attttctcag ttgggtccat cagcagtttt tcttcctgca tttattgttg   3960 

aaaactattg tttcatttct tcttttatag gccttattac tgcttaatcc aaatgtgtac   4020 

cattggtgag acacatacaa tgctctgaat acactacgaa tttgtattaa acacatcaga   4080 

atatttccaa atacaacata gtatagtcct gaatatgtac ttttaacaca agagagacta   4140 

ttcaataaaa actcactggg tctttcatgt ctttaagcta agtaagtgtt cagaaggttc   4200 

ttttttatat tgtcctccac ctccatcatt ttcaataaaa gatagggctt ttgctccctt   4260 

gttcttggag ggaccattat tacatctctg aactaccttt gtatccaaca tgttttaaat   4320 

ccttaaatga attgctttct cccaaaaaaa gcacagtata aagaaacaca agatttaatt   4380 

atttttctac ttggggggaa aaaagtcctc atgtagaagc acccactttt gcaatgttgt   4440 

tctaagctat ctatctaact ctcagcccat gataaagttc cttaagctgg tgattcctaa   4500 

tcaaggacaa gccaccctag tgtctcatgt ttgtatttgg tcccagttgg gtacatttta   4560 

aaatcctgat tttggagact taaaaccagg ttaatggcta agaatgggta acatgactct   4620 

tgttggattg ttattttttg tttgcaatgg ggaatttata agaagcatca agtctctttc   4680 

ttaccaaagt cttgttaggt ggtttatagt tcttttggct aacaaatcat tttggaaata   4740 

aagatttttt actac                                                    4755 

 
           
             70  
             443  
             DNA  
             human  
           
            70 

tttttttttt tttttccatt aacccaacac aagtttattt actaagtcaa gtcaaactga     60 

ggagtatttg tttctttggt agttggtaga caaagaatac atatacatat tctatttccc    120 

attaagcatt cgatcatgtt acaaaacaat ggcctagaga actatcattg aagatttacc    180 

aaatctgcct gaagcaaaat gtgataaact gcagaaatgg tggagaatga cactggaagt    240 

cataaagttg attctcaaac acgggtttga actgcatagg accgcttata tgcatatttt    300 

gataaatata ttgaaaattt ttttggaaat ttgcaacaat ttaaaaaact tgcagatgca    360 

ccatgtagct tagaaatact gaaaaactaa gaaaaaggtg tgtcatgaat tcatataata    420 

tatgtagaca ctagtctatt tta                                            443 

 
           
             71  
             2432  
             DNA  
             human  
           
            71 

ggcgagtggc gagtggcgag tgtcaggggg gcggccggcg ggggcggggc ggccggagga     60 

ggcgttggca gcgggctcgg acccacgcgg cgccgcggcc cgcctggcct gcagcgctcc    120 

cacccccggc ggcggcacga tgccctttga cttcaggagg tttgacatct acaggaaggt    180 

gcccaaggac cttacgcagc caacgtacac cggggccatt atctccatct gctgctgcct    240 

cttcatcctc ttcctcttcc tctcggagct caccggattt ataacgacag aagttgtgaa    300 

cgagctctat gtcgatgacc cagacaagga cagcggtggc aagatcgacg tcagtctgaa    360 

catcagttta cccaatctgc actgcgagtt ggttgggctt gacattcagg atgagatggg    420 

caggcacgaa gtgggccaca tcgacaactc catgaagatc ccgctgaaca atggggcagg    480 

ctgccgcttc gaggggcagt tcagcatcaa caaggtcccc ggcaacttcc acgtgtccac    540 

acacagtgcc acagcccagc cacagaaccc agacatgacg catgtcatcc acaagctctc    600 

ctttggggac acgctacagg tccagaacat ccacggagct ttcaatgctc tcgggggagc    660 

agacagactc acctccaacc ccctggcctc ccacgactac atcctgaaga ttgtgcccac    720 

ggtttatgag gacaagagtg gcaagcagcg gtactcctac cagtacacgg tggccaacaa    780 

ggaatacgtc gcctacagcc acacgggccg catcatccct gcaatctggt tccgctacga    840 

cctcagcccc atcacggtca agtacacaga gagacggcag ccgctgtaca gattcatcac    900 

cacgatctgt gccatcattg gcgggacctt caccgtcgcc ggcatcctgg actcatgcat    960 

cttcacagcc tctgaggcct ggaagaagat ccagctgggc aagatgcatt gacgccacac   1020 

ccagcctaat ggccgaggac cctgggcatc gccagccttg cctccagtgc cctgtctcct   1080 

ttggccctca atctggtccc aaatctggct gtgtcccaaa gggtgtgtgg gaagtggggg   1140 

gaaagtagag gatggctcga tgttttgcag ctacctcttt tccccgtgtt tctttttaga   1200 

caaattacac tgcctgaagt tgcagttccc ctttccctgg ggagccccaa gaacagagtc   1260 

aggcaagggg tggggagtcc agggatcttg gggacccctc ctaggagagc tgcagtctct   1320 

tccctcaggg gaacatccca gaatgcatat cgatcagctc tcagccaggc ttcgacaatc   1380 

tcgcagcccc cactaggtgg acacattaat gatttggttt ctcccctggg cagccaacct   1440 

gccccagagg caccagacct gggctttcag ctttgggacc aggctgccca aaggtactcc   1500 

tttatacacc cggcaccttc cacgaaagat ggtacttccc aagcaagccc ctatgatttg   1560 

tcactataga tggaaccctg acttctgccc catcccttcc tgcccaacct agaacccagg   1620 

cctcaagtct ttaccccacc cctttcttgt tcttccaaga agcagatgcc cagttgctca   1680 

gcagcagcgg tagagacttg aatctgccca ccagtcacaa ggcgggtcac agattcctct   1740 

tcctctcttc tcctcgttcc tctgaaccct ccaccaatgt gcctcagcct gtgtgctgtg   1800 

tggcaacagc attctggttc ccactgccaa gatctcccac cactctgctg ggatctgcag   1860 

tggcagggag tgggggttgt gtaaagggga agtcatcttt tgagatccag atagacatgg   1920 

tttgtgcact tacgtccaga tgggaagcat ccttcctgca accctaaaat aatcatgcag   1980 

cctctcagac ggacgccatc ggtcccaagg ccttaggtgg aggaagcaaa gcaggccagg   2040 

cctgtcctgt ccgtggacct ctaccttctg gactccctac gggtgcagag cacttgggtt   2100 

tctctacagc catcgtggcc cacttgacac tgtgctcctc catcagctgg tcacatgcca   2160 

acacgttccc agcccctgag gcagctccag ggtgccccac ctgctcctga ggtgggtccc   2220 

taccctgctg ctcctcttca tcctttccct tttgtcctga aagggaggag caatggtcca   2280 

ggcattaatt ccacccaggg aattttagct atgccctcat gtcccaggga gagagccaca   2340 

cgcctgtttt ccatttatag caagattgtt tgcatacttt tgtaatgaag gggagtgtcc   2400 

agtggaagga tttttaaaat tatcttatgg at                                 2432 

 
           
             72  
             2782  
             DNA  
             human  
           
            72 

gcggccgcgg cggggcggcg cgggaaccgg gccccggggg gagtcggccg ggctgctgct     60 

gctgctgctc caggtgctgc cgcccggggc tacggcaggg ccgggacgcc ggggcacgcg    120 

gggcgctggc ggcggcggcg tctgctggcc cggcgcggcc ccagcctttc cccgggacgc    180 

gcggctgctg ctgctcctgc cgccgctgcc gccactgtcg ccgccgccgc cgagctccgc    240 

gcccgcagcc tccgcctccc ggatggacgc tctgccccgc agcgggctga acctgaagga    300 

ggagccgctg ctgcccgccg gcctgggctc agtgcgctcc tggatgcagg gcgcgggcat    360 

cctggacgcc agcaccgcgg cgcagagtgg cgtgggtctg gcacgagcac attttgagaa    420 

gcagcctccc tccaacctca ggaaatccaa cttcttccac ttcgtgctgg ccatgtacga    480 

ccggcagggg cagcccgtgg aggtggagcg cacagccttc atcgacttcg tggaaaagga    540 

ccgagagccc ggggcggaaa agactaacaa tgggatccat taccgcctcc ggctggtgta    600 

taacaatgga ctgcggacag agcaagacct ctacgtgcgt ctcatcgact ccatgtccaa    660 

acaggccatc atctatgagg ggcaggacaa gaaccccgaa atgtgccgag tgctgctcac    720 

ccatgagatc atgtgcagcc ggtgctgtga ccggaagagc tgtggcaacc ggaatgagac    780 

gccctcagac cccgtcatca ttgacaggtt cttcctcaag ttcttcctca aatgcaacca    840 

gaactgcctg aagaatgcgg ggaatcccag agacatgcgc cgcttccagg tggtggtgtc    900 

cacgacggtg agcgtggacg gacacgtgct ggccgtgtcc gacaacatgt ttgtgcacaa    960 

caactccaag catggccgca gggcgcgccg cctggacccc tccgaagctg ccaccccctg   1020 

catcaaggcc atcagccccg gggagggctg gaccacgggc ggcgccaccg tcattgtcat   1080 

cggcgacaac ttcttcgacg ggttgcaggt cgtgttcgga aacgtgctcg tgtggagcga   1140 

gctcatcacg ccccacgcca tccgggtgca gacgcccccg cggcacatcc ccggggtggt   1200 

ggaggtgacc ctctcctaca agtccaagca gttttgcaag ggatgccccg gccgctttgt   1260 

ctacacagct ctgaacgagc ccaccattga ctacggattc cagaggctac agaaagtcat   1320 

tcccagacac cccggagacc ccgagaggct gcccaaggaa gtgctgctga agcgggcggc   1380 

cgacttggca gaagccctgt acggagtgcc cggcagtaac caggagctgc tcctgaagcg   1440 

cgcggcggac gtggccgagg ctctgtacag caccccccgc gcacccgggc cgctcgcacc   1500 

cctggccccg agccacccac actccgccgt cgtgggcatc aacgccttca gcagcccgct   1560 

ggccatcgcc gtcggggacg ccaccccggg gcccgagccg ggctacgcgc gcagctgcag   1620 

cagcgcgtcc ccccgcgggt tcgcgcccag ccccggctcg cagcagagcg gctacggcgg   1680 

cggcctcgga gctggcctgg gcggctacgg cgcgccgggc gtggccggcc tcggcgtgcc   1740 

tgggtccccc agcttcctca atggctccac cgccacctcg cccttcgcca aggagcgcct   1800 

tcgcccccgt gctgcgcccc ccaagctccc caccccaggc ctgccccaga gcccacggag   1860 

aggggcttcc agaccagtct tttgaggatt ctgacaagtt ccactctcca gcccgggggc   1920 

ttcagggcct ggcatactcc taattacggt ctgcagctgt tcccatggag cccggactgg   1980 

aggtccctct gggattcaca gccacacccc ggatggtggc acagacagat gcagggccag   2040 

ggccatgggc ggacctcaac ccgtgagctg aacggggaga ggccttcacc ccatgctcaa   2100 

gcctccccgc tagcagcccc acaggcttct ctcgcctccc tgtcttgggg tagtcagaag   2160 

ccccagcact gtgcagatgc tcttggcagg acagcatcgc agggaggtgc tgggattctg   2220 

ggcctcactg tctgggtctt ggttcctctg aaagagatgg atcttgtgca gaccagggtt   2280 

gttgagtgag gggagcgtgg gatggggacc gtgggaaaga ggacagctca gggagaagtg   2340 

acctggaaag gtcctgtttg catctgaccc atctcaactg gcccagcatc ccaacttctc   2400 

tgcagcgaaa gggtggcgcc ccgcagcctc gggaggcctg cccaggctcc cgtggagctt   2460 

ccaacagctg cttggccccg cagctgcccc cacttccttt gagacctgca ctctcatgct   2520 

tgccgcatca tgcctccctg tgggggcttt gggcatggag gaggcagaag agggggtgcc   2580 

aggcctcctg tatttggggt cttcccccag tggatgtctc atggactctg gccccacaca   2640 

ctcacaatga ctctggctgg ccccacgcag cgggcccagc cgccccccag gtggcctcac   2700 

attctgctct gctaagtttg gagaaaacag aacaataaac cagatgcagg tggtgcccgc   2760 

ccggcctctc acctgcctcc tt                                            2782 

 
           
             73  
             1722  
             DNA  
             human  
           
            73 

ggggaaaaga gctaggaaag agctgcaaag cagtgtgggc tttttccctt tttttgctcc     60 

ttttcattac ccctcctccg ttttcaccct tctccggact tcgcgtagaa cctgcgaatt    120 

tcgaagagga ggtggcaaag tgggagaaaa gaggtgttag ggtttggggt ttttttgttt    180 

ttgtttttgt tttttaattt cttgatttca acattttctc ccaccctctc ggctgcagcc    240 

aacgcctctt acctgttctg cggcgccgcg caccgctggc agctgagggt tagaaagcgg    300 

ggtgtatttt agattttaag caaaaatttt aaagataaat ccatttttct ctcccacccc    360 

caacgccatc tccactgcat ccgatctcat tatttcggtg gttgcttggg ggtgaacaat    420 

tttgtggctt tttttcccct ataattctga cccgctcagg cttgagggtt tctccggcct    480 

ccgctcactg cgtgcacctg gcgctgccct gcttccccca acctgttgca aggctttaat    540 

tcttgcaact gggacctgct cgcaggcacc ccagccctcc acctctctct acatttttgc    600 

aagtgtctgg gggagggcac ctgctctacc tgccagaaat tttaaaacaa aaacaaaaac    660 

aaaaaaatct ccgggggccc tcttggcccc tttatccctg cactctcgct ctcctgcccc    720 

accccgaggt aaagggggcg actaagagaa gatggtgttg ctcaccgcgg tcctcctgct    780 

gctggccgcc tatgcggggc cggcccagag cctgggctcc ttcgtgcact gcgagccctg    840 

cgacgagaaa gccctctcca tgtgcccccc cagccccctg ggctgcgagc tggtcaagga    900 

gccgggctgc ggctgctgca tgacctgcgc cctggccgag gggcagtcgt gcggcgtcta    960 

caccgagcgc tgcgcccagg ggctgcgctg cctcccccgg caggacgagg agaagccgct   1020 

gcacgccctg ctgcacggcc gcggggtttg cctcaacgaa aagagctacc gcgagcaagt   1080 

caagatcgag agagactccc gtgagcacga ggagcccacc acctctgaga tggccgagga   1140 

gacctactcc cccaagatct tccggcccaa acacacccgc atctccgagc tgaaggctga   1200 

agcagtgaag aaggaccgca gaaagaagct gacccagtcc aagtttgtcg ggggagccga   1260 

gaacactgcc cacccccgga tcatctctgc acctgagatg agacaggagt ctgagcaggg   1320 

cccctgccgc agacacatgg aggcttccct gcaggagctc aaagccagcc cacgcatggt   1380 

gccccgtgct gtgtacctgc ccaattgtga ccgcaaagga ttctacaaga gaaagcagtg   1440 

caaaccttcc cgtggccgca agcgtggcat ctgctggtgc gtggacaagt acgggatgaa   1500 

gctgccaggc atggagtacg ttgacgggga ctttcagtgc cacaccttcg acagcagcaa   1560 

cgttgagtga tgcgtccccc cccaaccttt ccctcacccc ctcccacccc cagccccgac   1620 

tccagccagc gcctccctcc accccaggac gccactcatt tcatctcatt taagggaaaa   1680 

atatatatct atctatttga ggaaaaaaaa aaaaaaaaaa aa                      1722 

 
           
             74  
             2626  
             DNA  
             human  
           
            74 

gggtacggct gcgagaagac gacagaaggg gatgtcacct gctttatttc tggctttggc     60 

ctgtggtctg tgatacccat cctgcttgat gttctgcaga atggcacttg actgctgggc    120 

atgcatgaag ttaagggcaa gaaacagtat gccatgtgtt ctgtaccatc atgtgtctct    180 

tcttgcttct gggcccttct actggtgaac tttcatcaag atctgcgcca tgccgtgtca    240 

ctatcaagcc attaagtttt gtctgggttg ctgtcagccc cagttggctt cctggtcaac    300 

aaggacctca agaactgcct gtggaccgag gccccctacc agtgcatgag acacacacct    360 

accctcccca gctttccagg aaccctactg gctgccagac tgatgggcgg gctggtatgt    420 

gtggacatgt gttcactgtc attatgctgt ggctccaggt gagggtgagg actgggccta    480 

tatagaatcc agataccatt gtcaacttcc cttattcccg tctaagatgt gagcagagtg    540 

ccatagtagg ggttctggga agaggtattt ctgatttgtg ggcctctgct tgcttgactt    600 

caggtcactt atacttctta ttttgcttgc ctgccttcat ccctcatttc ctccctctca    660 

ttcttctttc ctccctccct ttcctggtag cctcctttcc tccccttctg ccttcccctt    720 

ccttctttcc ttattctttt ttattttgtt taaatagtac cacagagaaa acaactgaaa    780 

aaccacattt ttctacatac agctggggag gtagctgaga acttggcact gcgcacacat    840 

actaggttga aagagagttg aggaaaccag aaggccaagt ggatctgctg gcaaaccctg    900 

aacctgtctc ctgcgcttgc tctacagttc tgaagttgaa aatcgttttc atgcctagca    960 

tctgcttgag ttataaaccc caaggcagcc atgtcataga ctagtgttta ctcttgtttt   1020 

gactttgttt taatgcttcc taagacccaa gtgcctcctg ctgtttcctc ctttgtggta   1080 

gcctctggcc atctggacct caatccccag ctttcccact ttcagcagtc ctttgctctc   1140 

tttgcttcta cctcaaatag ccccaggagt gggctttagt ctccaatatg gagcatctca   1200 

agcttctcct gggggatggg gattgggatg ggcggaatct gttttggatc tccgggttat   1260 

ttccagtggg tgtaaaagca gagctgggcc tttccctctc ttatccctga gggtgggtaa   1320 

gaaggactgt atctacacct gttcttccct accttctctt ttgttaggga ggcctcattc   1380 

taagttcctc aagagagtcc ttggcttaaa gctgtagcaa gggtgtgcta ggtgggggat   1440 

ttggagcaaa accgtcgagt aggcatgata ctggtatgga gtgggcctgc aaaatcagac   1500 

agaaatggct tgagaagccg cagggggagc atgcctgtct ctcagtgata gagtatggga   1560 

gggacctccc tagcttggaa aatgagaatt gaaggggtta tgaacaaata ggatgcctag   1620 

ttgaggatgt tcccaaagtt ttgtccaatc ttatcattag tagattttat aagccacaga   1680 

gacaaaccag aaacggaata atgttacttt ggatgcttta tttttttgtt ctaggtgtgg   1740 

ctttgtacat gcagaagaat gctatatgct gcacattttg cctttaaagt cttacgactt   1800 

tccccatttt agtctaatgg gaagatacag atgtgcaagt ctgctttttt gttttttgtt   1860 

attatttttt tttttgctct gtgttatgga cattttcaga catgcacaga agtggagagg   1920 

atggtccttg gaccccatgt gtccatcacc tagctgcatc acttatcagc tatggtcaac   1980 

ctggtttcat ctgtatctct ctcttttcac ctgtattgtt tattgaaaat ccaagacact   2040 

atgccaatgc aaccgtgact actttgggag attggtagtc tcttttgatg gtgatagtga   2100 

tggggtgcac tatcataatc acatcaggtc tgctttttgc ttttaatgtt aactaatgaa   2160 

gttccagaga tgggccttag aaatgtgttt taagaattaa caaggagtct caaaaagaaa   2220 

tgagagggat gcttcctttc ccttgcatct acaaaacaag agagagactg ttctgttgta   2280 

aaactctttc aaaaattctg atatggtaag gtacttgaga cccttcacca gaatgtcaat   2340 

ctttttttct gtgtaacatg gaaacttgtg tgaccattag cattgttatc agcttgtact   2400 

ggtctcataa ctctggtttt ggaagaataa tttggaaatt gttgctgtgt tctgtgaaaa   2460 

taacctcccc aaaataatta gtaactggtt gttctacttg gtaatttgac accctgttaa   2520 

taacgcaatt atttctgtgt tcttaaacag tataaatagt tgtaagtttg catgcatgat   2580 

ggaaaaataa aaacctgtat ctctgtcaaa aaaaaaaaaa aaaaaa                  2626 

 
           
             75  
             3337  
             DNA  
             human  
           
            75 

gtcgagcctc tagcccgccc gggtttcctt cgcagtcgcg caccgacgct caaacgcgcg     60 

ctccaacccg cagcctcctc ctgcctcacc gcccgaagat ggcggctctc aaactcctct    120 

cctccgggct tcggctctgc gcctctgccc gcggatctgg ggcaacctgg tacaagggat    180 

gtgtttgttc cttttccacc agtgctcatc gccataccaa gttttataca gatccagtag    240 

aagctgtaaa agacatccct gatggtgcca cggttttggt tggtggtttt gggctatgtg    300 

gaattccaga gaatcttata gatgctttac tgaaaactgg agtaaaagga ctaactgcag    360 

tcagcaacaa tgcaggggtt gacaattttg gtttggggct tttgcttcgg tcgaagcaga    420 

taaaacgcat ggtctcttca tatgtgggag aaaatgcaga atttgaacga cagtacttat    480 

ctggtgaatt agaagtggag ctgacaccac agggcacact tgcagagagg atccgtgcag    540 

gcggggctgg agttcctgca ttttacaccc caacagggta tgggaccctg gtacaagaag    600 

gaggatcgcc catcaaatac aacaaagatg gcagtgttgc cattgccagt aagccaagag    660 

aggtgaggga gttcaatggt cagcacttta ttttggagga agcaattaca ggggattttg    720 

ctttggtgaa agcctggaag gcggaccgag caggaaacgt gattttcagg aaaagtgcaa    780 

ggaatttcaa cttgccaatg tgcaaagctg cagaaaccac agtggtagag gttgaagaaa    840 

ttgtggatat tggagcattt gctccagaag acatccatat tcctcagatt tatgtacatc    900 

gccttataaa gggagaaaaa tatgagaaaa gaattgagcg tttatcaatc cggaaagagg    960 

gagatgggga agccaaatct gctaaacctg gagatgacgt aagggaacga atcatcaaga   1020 

gggccgctct tgagtttgag gatggcatgt atgctaattt gggcatagga atccctctcc   1080 

tggccagcaa ttttatcagc ccaaatataa ctgttcatct tcaaagtgaa aatggagttc   1140 

tgggtttggg tccatatcca cgacaacatg aagctgatgc agatctcatc aatgcaggca   1200 

aggaaacagt tactattctt ccaggagcct cttttttctc cagcgatgaa tcatttgcaa   1260 

tgattagagg tggacacgtc gatctgacaa tgctaggagc gatgcaggtt tccaaatatg   1320 

gtgacctggc taactggatg atacctggga agatggtgaa aggaatggga ggtgctatgg   1380 

atttagtgtc cagtgcgaaa accaaagtgg tggtcaccat ggagcattct gcaaagggaa   1440 

atgcacataa aatcatggag aaatgtacat taccattgac tggaaagcaa tgtgtcaacc   1500 

gcattattac tgaaaaggct gtgtttgatg tggacaagaa gaaagggttg actctgattg   1560 

agctctggga aggcctgaca gtggatgacg tacaaaagag tactgggtgt gattttgcag   1620 

tttcaccaaa actcatgcca atgcagcaga tcgcaaattg aaatatggat atttgtacca   1680 

ggctgcgtgt ttttcatttt aaacacacaa gatttaattg aaaggacatc aataatcata   1740 

attgtgtatt taacaggtgg ttttttatta gttttcttgt gtttcagact ttatgcagcc   1800 

atataaactg ttctctaggc atgctgtgac attttaataa aaagcaaaag gagcatttat   1860 

aattatctca tttgttaagg ctgagaaggt tgtttttata ataggtaatt atattgaatg   1920 

cattttcact gaatatggta tgtatgctaa attatatgaa cctttcccca agaagggccc   1980 

tagaaattga tgtggctttc ctcttaaata ttaattatta gtcctgaaag aaagataaca   2040 

tatgtgattt ttgtggttag gagagttgct gtcatgattg ttttttcttc agcctcctct   2100 

gacttttctt ttggggcttc agattttatg attacatctt gtccccctag aacatccccc   2160 

ttcctcccat actgctttta aacagatgcc caagaaggca agcaggaatg cctcttgtgg   2220 

gggagggcag ggagaaataa ctagttcaaa ccaactatct atctatgctt tgcaaagact   2280 

aaggcgtatt ataggaagag ggctagaaac ctaactgatt cttctcagtt ttctcatttt   2340 

aaaacagccc agtattcctt tgtatcctca agggtccttg agaatacttc tgttattgaa   2400 

accctgtggg ctacttgtac tgtacctcct ctcaagccaa gaagggctgt gggataattt   2460 

accatgaatc cttagtagca atgacagcag agttaaaaaa taaaaggtgt tttactttca   2520 

ggctcttgtt ttggttcaga ggagatttta aatattgaat gacacttcta cagaacaacg   2580 

gtttttcttc tgccaaggct acttccttta acgaagtgcc tttaattcag ccttatccaa   2640 

ctagggaaaa taatgttgga caagtctagg atttgaagag tcagtgaact tttagtgtca   2700 

gggaataaac atggtgggta gattaggttt gaaaaaaact tccttagagg tatttattct   2760 

caatacctga caggggccca tgggaatgac ttcagaagca tcccggataa tagatgggta   2820 

aaaagtctag gcaccctgaa gaacaggtga gacagctggc ctctggacag aggtaggcat   2880 

agtacagtac gatatatcat tcctctggtc ctaaatatac aaacttattc atgtttttag   2940 

gtgatgatgg tcattgaaac tcacttcttt tcaggtgtag ctacaattgt gtaatgtaca   3000 

atattagaga aaggacaggc tttttatgag taacacacac catatataaa acagcctttc   3060 

tggctgacca catggttaaa tgcatacctt cccagtactg gggggaaaat gacccttctt   3120 

agaatgtgca agttccatag agtaatatat tgatatgatt ttgaaaagaa ttgttgatag   3180 

ttacatcttc aaacttatca ttccagtatg catctttaag ataatgtgat tctaagtaga   3240 

tgactttata ttcttgatta aagagtgcta tacatgttaa gaaatgcatt aaggaataca   3300 

ataaatattc taaactgatg aaaaaaaaaa aaaaaaa                            3337 

 
           
             76  
             2460  
             DNA  
             human  
           
            76 

aaagtcaaac cccgacaccg cggcgggccg gtgagctcac tagctgaccc ggcaggtcag     60 

gatctggctt agcggcgccg cgagctccag tgcgcgcacc cgtggccgcc tcccagccct    120 

ctttgccgga cgagctctgg gccgccacaa gactaaggaa tggccacccc gcccaagaga    180 

agctgcccgt ctttctcagc cagctctgag gggacccgca tcaagaaaat ctccatcgaa    240 

gggaacatcg ctgcagggaa gtcaacattt gtgaatatcc ttaaacaatt gtgtgaagat    300 

tgggaagtgg ttcctgaacc tgttgccaga tggtgcaatg ttcaaagtac tcaagatgaa    360 

tttgaggaac ttacaatgtc tcagaaaaat ggtgggaatg ttcttcagat gatgtatgag    420 

aaacctgaac gatggtcttt taccttccaa acatatgcct gtctcagtcg aataagagct    480 

cagcttgcct ctctgaatgg caagctcaaa gatgcagaga aacctgtatt attttttgaa    540 

cgatctgtgt atagtgacag gtatattttt gcatctaatt tgtatgaatc tgaatgcatg    600 

aatgagacag agtggacaat ttatcaagac tggcatgact ggatgaataa ccaatttggc    660 

caaagccttg aattggatgg aatcatttat cttcaagcca ctccagagac atgcttacat    720 

agaatatatt tacggggaag aaatgaagag caaggcattc ctcttgaata tttagagaag    780 

cttcattata aacatgaaag ctggctcctg cataggacac tgaaaaccaa cttcgattat    840 

cttcaagagg tgcctatctt aacactggat gttaatgaag actttaaaga caaatatgaa    900 

agtctggttg aaaaggtcaa agagtttttg agtactttgt gatcttgctg aagactacag    960 

gcagccaaat ggttccagat acttcagctt tgtgtatctt cgtaacttca tattaatata   1020 

agtttcttta gaaaacccaa gtttttaatc gtttttgttt taaggaaaaa agatttttaa   1080 

aatgaatctt atgcaaaact ttttgatcag tttcttttct tttgtttttt ttttaaaaaa   1140 

gacatttaaa gacaaagaca ttatttctca tagcaggaaa tgtagaggta gatggttcca   1200 

gtatcagcat agtgactaaa ctacattata aaagatccag cttccttctg tcattcccct   1260 

cttttgtctt cctcagcagg ttggcttttt tccctggtgc ctctcacttc gttggtgacc   1320 

agtttcttaa actgaaagct ttaatgttac atagtaaatg gtagtgtgtc ctgtgtaaat   1380 

tagtgtacct attaaaagtt gcaaagtgga attaaaggaa tccctagaat aaggattctg   1440 

aagttttatt ttaaattatt atcttcttaa cagtttagtc ccacctctta cttcctgcct   1500 

cagtctgctt tctctactgt ctggattaat taggcagcct gctataaagt taaagtcaca   1560 

catttctatt ttgcaaacac tgtgattact ctttgctttg tagtttgctt tgctttgtag   1620 

ggttctgctt ttaagttttt ctctttttca gacaaattac tgataaaaat gatattgctc   1680 

tatatgtaat atatcctgaa agcattattt tttgttgaat aggaaataaa attaatgaag   1740 

acagaggcta gaaagcatcc attaattaat gagacacact taactactta tctctaaacc   1800 

atctatgtga atatttgtaa aaataatgaa tggactcatc ttagttctgt atataaatat   1860 

attttctttc tagtttgttt agttaaggtg tgcagtgttt ttcctgtgta ttaaaccttt   1920 

ccattttacg ttttagaaaa ttttatgtat tttaaaataa ggggaagagt cattttcacc   1980 

tttaaactac tatttttctt tccaagtcat ttttgttttt ggtttcttat tcaaagatga   2040 

taatttagtg gattaaccag tccagacgca ctgatctttg caaaggagac ttaatttcaa   2100 

atctgtaatt accatacata aactgtctca ttatacgtat gcattttttt agtttgtttt   2160 

tgtttggtat aaattaattt gttaattaaa tatttcttaa gtataaacct tatgaactac   2220 

agtggagcta cactcattga aatgtaattt cagttctaaa aagatgtaat aatcatttta   2280 

gaattaaaat ttattctact tttaaataaa ttatgaatat taaaggtgaa aattgtataa   2340 

attactttga ttccatttta agtggagaca tatttcagtg atttttagta acctttaaaa   2400 

atgtataatg acttttaaaa tttgtagaat tgaaaagacg ctaataaaaa tttattattt   2460 

 
           
             77  
             7680  
             DNA  
             human  
           
            77 

gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc     60 

tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct    120 

ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg    180 

gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc    240 

gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt    300 

ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa    360 

ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca    420 

gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact    480 

aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct    540 

caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag    600 

aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag    660 

atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc    720 

tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg    780 

atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca    840 

acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag    900 

acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca    960 

cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc   1020 

ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc   1080 

gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact   1140 

attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca   1200 

tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa   1260 

catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg   1320 

aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact   1380 

gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa   1440 

gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac   1500 

ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg   1560 

tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat   1620 

ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa   1680 

gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac   1740 

atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag   1800 

atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct   1860 

tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat   1920 

gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc   1980 

acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac   2040 

agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc   2100 

actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga   2160 

gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagagat   2220 

caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccat cagcagttcc   2280 

accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttg gtttaaaaac   2340 

aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcag cacgctgttt   2400 

attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccac caaccagaag   2460 

ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaa gtctaatctg   2520 

gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggct cctattaacc   2580 

ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgacta cctatcaatt   2640 

ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctccc ttatgatgcc   2700 

agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttgg aagaggggct   2760 

tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctac gtgccggact   2820 

gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagc tctgatgact   2880 

gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacct gctgggagcc   2940 

tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaata tggaaatctc   3000 

tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgc agcactacac   3060 

atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaa accaagacta   3120 

gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaaga taaaagtctg   3180 

agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccat cactatggaa   3240 

gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtc ttccagaaag   3300 

tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaa cgtggtgaag   3360 

atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgt gagaaaagga   3420 

gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaa aatctacagc   3480 

accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctc cttaggtggg   3540 

tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgag ggaaggcatg   3600 

aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgct ggactgctgg   3660 

cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaact aggtgatttg   3720 

cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgc catactgaca   3780 

ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttctt caaggaaagt   3840 

atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgt aaatgctttc   3900 

aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaa tgccacctcc   3960 

atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccat gctgaagcgc   4020 

ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgag agtaaccagt   4080 

aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgcca ttccagctgt   4140 

gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagct ggaaaggaaa   4200 

atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactc caccccaccc   4260 

atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttat acccccagga   4320 

aactagcttt tgccagtatt atgcatatat aagtttacac ctttatcttt ccatgggagc   4380 

cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaaca agaatgtaac   4440 

tccagataga gaaatagtga caagtgaaga acactactgc taaatcctca tgttactcag   4500 

tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccg ccacctcagg   4560 

gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatc acgtacccca   4620 

ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagcccc aggggatcac   4680 

tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatg tgaggaggaa   4740 

aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggca tgagaaagaa   4800 

tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgcca tttcagtggc   4860 

ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatgg acagcgatga   4920 

ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttt tggaactaaa   4980 

gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcatt cgtggcatgt   5040 

tttgatttgt agcactgagg gtggcactca actctgagcc catacttttg gctcctctag   5100 

taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgat ggccttacac   5160 

tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacactta actcaatttc   5220 

ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaaga atgaaaatgc   5280 

agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaa aaggtcaata   5340 

aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaaca cagttgggac   5400 

ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattcc actatctcac   5460 

actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcact ttaagctcct   5520 

tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttggga ctcaggatat   5580 

tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaa acttgcctgg   5640 

ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctact cttcagggtc   5700 

taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctat ttatgcaagt   5760 

tagggtctat gtatttagga tgcgcctact cttcagggtc taaagatcaa gtgggccttg   5820 

gatcgctaag ctggctctgt ttgatgctat ttatgcaagt tagggtctat gtatttagga   5880 

tgtctgcacc ttctgcagcc agtcagaagc tggagaggca acagtggatt gctgcttctt   5940 

ggggagaaga gtatgcttcc ttttatccat gtaatttaac tgtagaacct gagctctaag   6000 

taaccgaaga atgtatgcct ctgttcttat gtgccacatc cttgtttaaa ggctctctgt   6060 

atgaagagat gggaccgtca tcagcacatt ccctagtgag cctactggct cctggcagcg   6120 

gcttttgtgg aagactcact agccagaaga gaggagtggg acagtcctct ccaccaagat   6180 

ctaaatccaa acaaaagcag gctagagcca gaagagagga caaatctttg ttgttcctct   6240 

tctttacaca tacgcaaacc acctgtgaca gctggcaatt ttataaatca ggtaactgga   6300 

aggaggttaa actcagaaaa aagaagacct cagtcaattc tctacttttt tttttttttt   6360 

tccaaatcag ataatagccc agcaaatagt gataacaaat aaaaccttag ctgttcatgt   6420 

cttgatttca ataattaatt cttaatcatt aagagaccat aataaatact ccttttcaag   6480 

agaaaagcaa aaccattaga attgttactc agctccttca aactcaggtt tgtagcatac   6540 

atgagtccat ccatcagtca aagaatggtt ccatctggag tcttaatgta gaaagaaaaa   6600 

tggagacttg taataatgag ctagttacaa agtgcttgtt cattaaaata gcactgaaaa   6660 

ttgaaacatg aattaactga taatattcca atcatttgcc atttatgaca aaaatggttg   6720 

gcactaacaa agaacgagca cttcctttca gagtttctga gataatgtac gtggaacagt   6780 

ctgggtggaa tggggctgaa accatgtgca agtctgtgtc ttgtcagtcc aagaagtgac   6840 

accgagatgt taattttagg gacccgtgcc ttgtttccta gcccacaaga atgcaaacat   6900 

caaacagata ctcgctagcc tcatttaaat tgattaaagg aggagtgcat ctttggccga   6960 

cagtggtgta actgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgggtgtg   7020 

ggtgtatgtg tgttttgtgc ataactattt aaggaaactg gaattttaaa gttactttta   7080 

tacaaaccaa gaatatatgc tacagatata agacagacat ggtttggtcc tatatttcta   7140 

gtcatgatga atgtattttg tataccatct tcatataata tacttaaaaa tatttcttaa   7200 

ttgggatttg taatcgtacc aacttaattg ataaacttgg caactgcttt tatgttctgt   7260 

ctccttccat aaatttttca aaatactaat tcaacaaaga aaaagctctt ttttttccta   7320 

aaataaactc aaatttatcc ttgtttagag cagagaaaaa ttaagaaaaa ctttgaaatg   7380 

gtctcaaaaa attgctaaat attttcaatg gaaaactaaa tgttagttta gctgattgta   7440 

tggggttttc gaacctttca ctttttgttt gttttaccta tttcacaact gtgtaaattg   7500 

ccaataattc ctgtccatga aaatgcaaat tatccagtgt agatatattt gaccatcacc   7560 

ctatggatat tggctagttt tgcctttatt aagcaaattc atttcagcct gaatgtctgc   7620 

ctatatattc tctgctcttt gtattctcct ttgaacccgt taaaacatcc tgtggcactc   7680 

 
           
             78  
             3160  
             DNA  
             human  
           
            78 

attctcgccg cgcccgggcg gacgatccag cgaacagccc cgcttctaac ccgagatgct     60 

gctgccggcg cccgcgctcc gccgcgccct gctgtcccgc ccctggaccg gggccggcct    120 

gcggtggaag cacacctcct ccctgaaggt ggccaacgag cccgtcttag ccttcacgca    180 

gggcagccct gagcgagatg ccctgcaaaa ggccttgaag gacctgaagg gccggatgga    240 

agccatccca tgcgtggtgg gggatgagga ggtgtggacg tcggacgtgc agtaccaagt    300 

gtcgcctttt aaccatggac ataaggtggc caagttctgt tatgcagaca agagcctgct    360 

caacaaagcc attgaggctg ccctggctgc ccggaaagag tgggacctga agcctattgc    420 

agaccgggcc cagatcttcc tgaaggcggc agacatgctg agtgggccgc gcagggctga    480 

gatcctcgcc aagaccatgg tgggacaggg taagaccgtg atccaagcgg agattgacgc    540 

tgcagcggaa ctcatcgact tcttccggtt caatgccaag tatgcggtgg agctggaggg    600 

gcagcagccc atcagcgtgc ccccgagcac caacagcacg gtgtaccggg gtctggaggg    660 

cttcgtggcg gccatctcgc cctttaactt cactgcaatc ggcggcaacc tggcgggggc    720 

accggccctg atgggcaacg tggtcctatg gaagcccagt gacactgcca tgctggccag    780 

ctatgctgtc taccgcatcc ttcgggaggc tggcctgccc cccaacatca tccagtttgt    840 

gccagctgat gggcccctat ttggggacac tgtcaccagc tcagagcacc tctgtggcat    900 

caacttcaca ggcagtgtgc ccaccttcaa acacctgtgg aagcaggtgg cccagaacct    960 

ggaccggttc cacaccttcc cacgcctggc tggagagtgc ggcggaaaga acttccactt   1020 

cgtgcaccgc tcggccgacg tggagagcgt ggtgagcggg accctccgct cagccttcga   1080 

gtacggtggc cagaagtgtt ccgcctgctc gcgtctctac gtgccgcact cgctgtggcc   1140 

gcagatcaaa gggcggctgc tggaggagca cagtcggatc aaagtgggcg accctgcaga   1200 

ggattttggg accttcttct ctgcagtgat tgatgccaag tcctttgccc gtatcaagaa   1260 

gtggctggag cacgcgcgct cctcgcccag cctcaccatc ctggctgggg gcaagtgtga   1320 

tgactccgtg ggctactttg tggagccctg catcgtggag agcaaggacc ctcaggagcc   1380 

catcatgaag gaggagatct tcgggcctgt actgtctgtg tacgtctacc cggacgacaa   1440 

gtacaaggag acgctgcagc tggttgacag caccaccagc tatggcctca cgggggcagt   1500 

gttctcccag gataaggacg tcgtgcagga ggccacaaag gtgctgagga atgctgccgg   1560 

caacttctac atcaacgaca agtccactgg ctcgatagtg ggccagcagc cctttggggg   1620 

ggcccgagcc tctggaacca atgacaagcc agggggccca cactacatcc tgcgctggac   1680 

gtcgccgcag gtcatcaagg agacacataa gcccctgggg gactggagct acgcgtacat   1740 

gcagtgagcc cctctcgggc tccaccgtcc agctgtctgt ccgtccaggt ggccgacctc   1800 

actgcacaga ccccactcca gcccctccac cccttcttca tgcacagctg cctttctata   1860 

atccgggctt gactcccttc ttaccactgt attctggcct ctcccatgcc tcaggctctg   1920 

gtttgagatc gtgctgggga ggaacatggc cactacccct tatcccatcg gccatgtggg   1980 

aggtatgacc ctggtgcctg gcaggttctc cctctgccct ccactgggcc cagtggctca   2040 

gggacctggg gaaaggagat ggagcagctc ttgggatcct ttggggaaaa ggaggccatt   2100 

ctgggcccct tggcaaacct caccactcac agaggctcct ggccttgatc cctgcccctc   2160 

caggtgtcca gggtaaagtg taactcagac tgacctgtgg ggcacagggg gcaccagctg   2220 

gccttgccct ctctggtctg ggctgtctac cttcctcact gtatctttgc ccagacccac   2280 

ctgggccagt aggcccctgt ccccagccac acaccttaga tgctggcatg ccttactcca   2340 

ggtgcctgtg tttggccgag gcctgtgtga ttcccggtct gcaccacatg gcggggttgg   2400 

ggggccgctg gaggccacct gccaaggcgt gggatgggat ggtcctgccg gtttaggccg   2460 

tgattctgga aaaccttgga tgggccttcg tcctatgtca gccttccctt tgatcctcag   2520 

gccctacctg tagagacctc cactcctaga gccagtctca gggtctggga tttccctgca   2580 

ggagctcagc caccactgtg ccatggtgac acaggccaag gcagacattg gccctccctt   2640 

ctcccagccc ccagaggcct ggccttgggt tcgtcagcat gggccgagga cgttgcctgt   2700 

agaatcctcc tctgcctggg agtggctctg tgtggaccag tccctcactg gcccattctt   2760 

tttttgacgc agccaatctg tgaccacgat tcctcccaca gatgcctcct gcttggattc   2820 

tgagtggtca gagatctgta aagcatgact ttcaaggatg gttcttaggg gactgtgaaa   2880 

gtgttgggtc ttcctccagg atgcctgcat gggaccccac ccggagctgg tgtggccatt   2940 

ccccaagtgc cactggccca tggatggggg tgggtgctgg tgccagctgg gctgggtgtg   3000 

ggttctgtgt ccttccagga tatgtgtcat ttcccatgag gggccggggc aggtggctgg   3060 

gtgggggcac aggctggagt attcttagtt ctactggttc tacactgtga ggtggcaatg   3120 

ggatttgctc agatgccacc caataaaatg cctgttactt                         3160 

 
           
             79  
             1546  
             DNA  
             human  
           
            79 

cacggccgga gagacgcgga ggaggagaca tgagccggcg ggcgcccaga cggagcggcc     60 

gtgacgcttt cgcgctgcag ccgcgcgccc cgaccccgga gcgctgaccc ctggccccac    120 

gcagctccgc gcccgggccg gagagcgcaa ctcggcttcc agacccgccg cgcatgctgt    180 

ccccggactg agccgggcag ccagcctccc acggacgccc ggacggccgg ccggccagca    240 

gtgagcgagc ttccccgcac cggccaggcg cctcctgcac agcggctgcc gccccgcagc    300 

ccctgcgcca gcccggaggg cgcagcgctc gggaggagcc gcgcggggcg ctgatgccgc    360 

agggcgcgcc gcggagcgcc ccggagcagc agagtctgca gcagcagcag ccggcgagga    420 

gggagcagca gcagcggcgg cggcggcggc ggcggcggcg gaggcgcccg gtcccggccg    480 

cgcggagcgg acatgtgcag gctgggctag gagccgccgc ctccctcccg cccagcgatg    540 

tattcagcgc cctccgcctg cacttgcctg tgtttacact tcctgctgct gtgcttccag    600 

gtacaggtgc tggttgccga ggagaacgtg gacttccgca tccacgtgga gaaccagacg    660 

cgggctcggg acgatgtgag ccgtaagcag ctgcggctgt accagctcta cagccggacc    720 

agtgggaaac acatccaggt cctgggccgc aggatcagtg cccgcggcga ggatggggac    780 

aagtatgccc agctcctagt ggagacagac accttcggta gtcaagtccg gatcaagggc    840 

aaggagacgg aattctacct gtgcatgaac cgcaaaggca agctcgtggg gaagcccgat    900 

ggcaccagca aggagtgtgt gttcatcgag aaggttctgg agaacaacta cacggccctg    960 

atgtcggcta agtactccgg ctggtacgtg ggcttcacca agaaggggcg gccgcggaag   1020 

ggccccaaga cccgggagaa ccagcaggac gtgcatttca tgaagcgcta ccccaagggg   1080 

cagccggagc ttcagaagcc cttcaagtac acgacggtga ccaagaggtc ccgtcggatc   1140 

cggcccacac accctgccta ggccaccccg ccgcggcccc tcaggtcgcc ctggccacac   1200 

tcacactccc agaaaactgc atcagaggaa tatttttaca tgaaaaataa ggaagaagct   1260 

ctatttttgt acattgtgtt taaaagaaga caaaaactga accaaaactc ttggggggag   1320 

gggtgataag gattttattg ttgacttgaa acccccgatg acaaaagact cacgcaaagg   1380 

gactgtagtc aacccacagg tgcttgtctc tctctaggaa cagacaactc taaactcgtc   1440 

cccagaggag gacttgaatg aggaaaccaa cactttgaga aaccaaagtc ctttttccca   1500 

aaggttctga aaggaaaaaa aaaaaaaaac aaaaaaaaaa aaaaaa                  1546 

 
           
             80  
             2819  
             DNA  
             human  
           
            80 

ctgggcccag ctcccccgag aggtggtcgg atcctctggg ctgctcggtc gatgcctgtg     60 

ccactgacgt ccaggcatga ggtggttcct gccctggacg ctggcagcag tgacagcagc    120 

agccgccagc accgtcctgg ccacggccct ctctccagcc cctacgacca tggactttac    180 

cccagctcca ctggaggaca cctcctcacg cccccaattc tgcaagtggc catgtgagtg    240 

cccgccatcc ccaccccgct gcccgctggg ggtcagcctc atcacagatg gctgtgagtg    300 

ctgtaagatg tgcgctcagc agcttgggga caactgcacg gaggctgcca tctgtgaccc    360 

ccaccggggc ctctactgtg actacagcgg ggaccgcccg aggtacgcaa taggagtgtg    420 

tgcacaggtg gtcggtgtgg gctgcgtcct ggatggggtg cgctacaaca acggccagtc    480 

cttccagcct aactgcaagt acaactgcac gtgcatcgac ggcgcggtgg gctgcacacc    540 

actgtgcctc cgagtgcgcc ccccgcgtct ctggtgcccc cacccgcggc gcgtgagcat    600 

acctggccac tgctgtgagc agtgggtatg tgaggacgac gccaagaggc cacgcaagac    660 

cgcaccccgt gacacaggag ccttcgatgc tgtgggtgag gtggaggcat ggcacaggaa    720 

ctgcatagcc tacacaagcc cctggagccc ttgctccacc agctgcggcc tgggggtctc    780 

cactcggatc tccaatgtta acgcccagtg ctggcctgag caagagagcc gcctctgcaa    840 

cttgcggcca tgcgatgtgg acatccatac actcattaag gcagggaaga agtgtctggc    900 

tgtgtaccag ccagaggcat ccatgaactt cacacttgcg ggctgcatca gcacacgctc    960 

ctatcaaccc aagtactgtg gagtttgcat ggacaatagg tgctgcatcc cctacaagtc   1020 

taagactatc gacgtgtcct tccagtgtcc tgatgggctt ggcttctccc gccaggtcct   1080 

atggattaat gcctgcttct gtaacctgag ctgtaggaat cccaatgaca tctttgctga   1140 

cttggaatcc taccctgact tctcagaaat tgccaactag gcaggcacaa atcttgggtc   1200 

ttggggacta acccaatgcc tgtgaagcag tcagccctta tggccaataa cttttcacca   1260 

atgagcctta gttaccctga tctggaccct tggcctccat ttctgtctct aaccattcaa   1320 

atgacgcctg atggtgctgc tcaggcccat gctatgagtt ttctccttga tatcattcag   1380 

catctactct aaagaaaaat gcctgtctct agctgttctg gactacaccc aagcctgatc   1440 

cagcctttcc aagtcactag aagtcctgct ggatcttgcc taaatcccaa gaaatggaat   1500 

caggtagact tttaatatca ctaatttctt ctttagatgc caaaccacaa gactctttgg   1560 

gtccattcag atgaatagat ggaatttgga acaatagaat aatctattat ttggagcctg   1620 

ccaagaggta ctgtaatggg taattctgac gtcagcgcac caaaactatc ctgattccaa   1680 

atatgtatgc acctcaaggt catcaaacat ttgccaagtg agttgaatag ttgcttaatt   1740 

ttgattttta atggaaagtt gtatccatta acctgggcat tgttgaggtt aagtttctct   1800 

tcacccctac actgtgaagg gtacagatta ggtttgtccc agtcagaaat aaaatttgat   1860 

aaacattcct gttgatggga aaagccccca gttaatactc cagagacagg gaaaggtcag   1920 

cccgtttcag aaggaccaat tgactctcac actgaatcag ctgctgactg gcagggcttt   1980 

gggcagttgg ccaggctctt ccttgaatct tctcccttgt cctgcttggg gttcatagga   2040 

attggtaagg cctctggact ggcctgtctg gcccctgaga gtggtgccct ggaacactcc   2100 

tctactctta cagagccttg agagacccag ctgcagacca tgccagaccc actgaaatga   2160 

ccaagacagg ttcaggtagg ggtgtgggtc aaaccaagaa gtgggtgccc ttggtagcag   2220 

cctggggtga cctctagagc tggaggctgt gggactccag gggcccccgt gttcaggaca   2280 

catctattgc agagactcat ttcacagcct ttcgttctgc tgaccaaatg gccagttttc   2340 

tggtaggaag atggaggttt accggttgtt tagaaacaga aatagactta ataaaggttt   2400 

aaagctgaag aggttgaagc taaaaggaaa aggttgttgt taatgaatat caggctatta   2460 

tttattgtat taggaaaata taatatttac tgttagaatt cttttattta gggccttttc   2520 

tgtgccagac attgctctca gtgctttgca tgtattagct cactgaatct tcacgacaat   2580 

gttgagaagt tcccattatt atttctgttc ttacaaatgt gaaacggaag ctcatagagg   2640 

tgagaaaact caaccagagt cacccagttg gtgactggga aagttaggat tcagatcgaa   2700 

attggactgt ctttataacc catattttcc ccctgttttt agagcttcca aatgtgtcag   2760 

aataggaaaa cattgcaata aatggcttga ttttttaaaa aaaaaaaaaa aaaaaaaaa    2819 

 
           
             81  
             2584  
             DNA  
             human  
           
            81 

tggcggcggc ggcggcggtt gtcccggctg tgccggttgg tgtggcccgt cagcccgcgt     60 

accacagcgc ccgggccgcg tcgagcccag tacagccaag ccgctgcggc cgggtccggc    120 

gcgggcggcg cgcgcagacg gagggcggcg gccgcggcca gggcggcccg tgggaccgcg    180 

ggcccccggc gcagcgctgc ccggctcccg gccctgccgg cctcctccct tggcgccgcg    240 

gccatggcgg ccagcgcgaa gcggaagcag gaggagaagc acctgaagat gctgcgggac    300 

atgaccggcc tcccgcgcaa ccgaaagtgc ttcgactgcg accagcgcgg ccccacctac    360 

gttaacatga cggtcggctc cttcgtgtgt acctcctgct ccggcagcct gcgaggatta    420 

aatccaccac acagggtgaa atctatctcc atgacaacat tcacacaaca ggaaattgaa    480 

ttcttacaaa aacatggaaa tgaagtctgt aaacagattt ggctaggatt atttgatgat    540 

agatcttcag caattccaga cttcagggat ccacaaaaag tgaaagagtt tctacaagaa    600 

aagtatgaaa agaaaagatg gtatgtcccg ccagaacaag ccaaagtcgt ggcatcagtt    660 

catgcatcta tttcagggtc ctctgccagt agcacaagca gcacacctga ggtcaaacca    720 

ctgaaatctc ttttagggga ttctgcacca acactgcact taaataaggg cacacctagt    780 

cagtccccag ttgtaggtcg ttctcaaggg cagcagcagg agaagaagca atttgacctt    840 

ttaagtgatc tcggctcaga catctttgct gctccagctc ctcagtcaac agctacagcc    900 

aattttgcta actttgcaca tttcaacagt catgcagctc agaattctgc aaatgcagat    960 

tttgcaaact ttgatgcatt tggacagtct agtggttcga gtaattttgg aggtttcccc   1020 

acagcaagtc actctccttt tcagccccaa actacaggtg gaagtgctgc atcagtaaat   1080 

gctaattttg ctcattttga taacttcccc aaatcctcca gtgctgattt tggaaccttc   1140 

aatacttccc agagtcatca aacagcatca gctgttagta aagtttcaac gaacaaagct   1200 

ggtttacaga ctgcagacaa atatgcagca cttgctaatt tagacaatat cttcagtgcc   1260 

gggcaaggtg gtgatcaggg aagtggcttt gggaccacag gtaaagctcc tgttggttct   1320 

gtggtttcag ttcccagtca gtcaagtgca tcttcagaca agtatgcagc tctggcagaa   1380 

ctagacagcg ttttcagttc tgcagccacc tccagtaatg cgtatacttc cacaagtaat   1440 

gctagcagca atgtttttgg aacagtgcca gtggttgctt ctgcacagac acagcctgct   1500 

tcatcaagtg tgcctgctcc atttggacgt acgccttcca caaatccatt tgttgctgct   1560 

gctggtcctt ctgtggcatc ttctacaaac ccatttcaga ccaatgccag aggagcaaca   1620 

gcggcaacct ttggcactgc atccatgagc atgcccacgg gattcggcac tcctgctccc   1680 

tacagtcttc ccaccagctt tagtggcagc tttcagcagc ctgcctttcc agcccaagca   1740 

gctttccctc aacagacagc tttttctcaa cagcccaatg gtgcaggttt tgcagcattt   1800 

ggacaaacaa agccagtagt aacccctttt ggtcaagttg cagctgctgg agtatctagt   1860 

aatcctttta tgactggtgc accaacagga caatttccaa caggaagctc atcaaccaat   1920 

cctttcttat agccttatat agacaattta ctggaacgaa cttttatgtg gtcacattac   1980 

atctctccac ctcttgcact gttgtcttgt ttcactgatc ttagctttaa acacaagaga   2040 

agtctttaaa aagcctgcat tgtgtattaa acaccaggta atatgtgcaa aaccgagggc   2100 

tccagtaaca ccttctaacc tgtgaattgg cagaaaaggg tagcggtatc atgtatatta   2160 

aaattggcta atattaagtt attgcagata ccacattcat tatgctgcag tactgtacat   2220 

atttttctta gaaattagct atttgtgcat atcagtattt gtaactttaa cacattgtta   2280 

tgtgagaaat gttactgggg aaatagatca gccactttta aggtgctgtc atatatcttg   2340 

gaatgaatga cctaaaatca ttttaaccat tgctactgga aagtaacaga gtcaaaattg   2400 

gaaggtttta ttcattcttg aatttttcct ttctaaagag ctcttctatt tatacatgcc   2460 

taaattcttt taaaatgtag agggatacct gtctgcataa taaagctgat catgttttgc   2520 

tacagtttgc aggtgaaaaa aaataaatat tataaaataa aaaaaaaaaa aaagaaaaaa   2580 

aaaa                                                                2584 

 
           
             82  
             2115  
             DNA  
             human  
           
            82 

gaaatgaacc tctcttattg atttttattg gcctagagcc aggagtactg cattcagttg     60 

actttcaggg taaaaagaaa acagtcctgg ttgttgtcat cataaacata tggaccagtg    120 

tgatggtgaa atgagatgag gctccgcaat ggaactgtag ccactgcttt agcatttatc    180 

acttccttcc ttactttgtc ttggtatact acatggcaaa atgggaaaga aaaactgatt    240 

gcttatcaac gagaattcct tgctttgaaa gaacgtcttc gaatagctga acacagaatc    300 

tcacagcgct cttctgaatt aaatacgatt gtgcaacagt tcaagcgtgt aggagcagaa    360 

acaaatggaa gtaaggatgc gttgaataag ttttcagata ataccctaaa gctgttaaag    420 

gagttaacaa gcaaaaaatc tcttcaagtg ccaagtattt attatcattt gcctcattta    480 

ttgaaaaatg aaggaagtct tcaacctgct gtacagattg gcaacggaag aacaggagtt    540 

tcaatagtca tgggcattcc cacagtgaag agagaagtta aatcttacct catagaaact    600 

cttcattccc ttattgataa cctgtatcct gaagagaagt tggactgtgt tatagtagtc    660 

ttcataggag agacagatat tgattatgta catggtgttg tagccaacct ggagaaagaa    720 

ttttctaaag aaatcagttc tggcttggtg gaagtcatat caccccctga aagctattat    780 

cctgacttga caaacctaaa ggagacattt ggagactcca aagaaagagt aagatggaga    840 

acaaagcaaa acctagatta ctgttttcta atgatgtatg ctcaagaaaa gggcatatat    900 

tacattcagc ttgaagatga tattattgtc aaacaaaatt attttaatac cataaaaaat    960 

tttgcacttc aactttcttc tgaggaatgg atgattctag agttttccca gctgggcttc   1020 

attggtaaaa tgtttcaagc gccggatctt actctgattg tagaattcat attcatgttt   1080 

tacaaggaga aacccattga ttggctcctg gaccatattc tctgggtgaa agtctgcaac   1140 

cctgaaaaag atgcaaaaca ttgtgataga cagaaagcaa atctgcgaat tcgcttcaga   1200 

ccttcccttt tccaacatgt tggtctgcac tcatcactat caggaaaaat ccaaaaactc   1260 

acggataaag attatatgaa accattactt cttaaaatcc atgtaaaccc acctgcggag   1320 

gtatctactt ccttgaaggt ctaccaaggg catacgctgg agaaaactta catgggagag   1380 

gatttcttct gggctatcac accgatagct ggagactaca tcttgtttaa atttgataaa   1440 

ccagtcaatg tagaaagtta tttgttccat agcggcaacc aagaacatcc tggagatatt   1500 

ctgctaaaca caactgtgga agttttgcct tttaagagtg aaggtttgga aataagcaaa   1560 

gaaaccaaag acaaacgatt agaagatggc tatttcagaa taggaaaatt tgagaatggt   1620 

gttgcagaag gaatggtgga tccaagtctc aatcccattt cagcctttcg actttcagtt   1680 

attcagaatt ctgctgtttg ggccattctt aatgagattc atattaaaaa agccaccaac   1740 

tgatcatctg agaaaccaac acattttttc ctgtgaattt gttaattaaa gatagttaag   1800 

catgtatctt ttttttattt ctacttgaac actacctctt gtgaagtcta ctgtagataa   1860 

gacgattgtc atttccactt ggaaagtgaa tctcccataa taattgtatt tgtttgaaac   1920 

taagctgtcc tcagatttta acttgactca aacatttttc aattatgaca gcctgttaat   1980 

atgacttgta ctattttggt attatactaa tacataagag ttgtacatat tgttacattc   2040 

tttaaatttg agaaaaacta atgttacata cattttatga agggggtact tttgaggttc   2100 

acttatttta ctatt                                                    2115 

 
           
             83  
             1635  
             DNA  
             human  
           
            83 

gggggtggcg gggacgcgag tggcggccgc ggggccccgg acaagggtcc gcagagctgc     60 

agccttcgag ggccagccct ctccgagtcc ggggctgggt cccaccagtg acaaggcggc    120 

agccccgcgc acaccaaaga gaaagcggct gtggcggcag cggcagcccc agccatgctg    180 

tgttatgtga cgaggccgga cgcggtgctg atggaggtgg aggtggaggc gaaagccaac    240 

ggcgaggact gcctcaacca ggtgtgcagg cgactgggaa tcatagaagt tgactatttt    300 

ggactgcaat ttacgggtag caaaggtgaa agtttatggc taaacctgag aaaccggatc    360 

tcccagcaga tggatgggct agccccttac aggcttaaac ttagagtcaa gttcttcgtg    420 

gagcctcatc tcatcttaca ggagcagact aggcatatct ttttcttgca catcaaggag    480 

gccctcttgg caggccacct cttgtgttcc ccagagcagg cagtggaact cagtgccctc    540 

ctggcccaga ccaagtttgg agactacaac cagaacactg ccaagtataa ctatgaggag    600 

ctctgtgcca aggagctctc ctctgccacc ttgaacagca ttgttgcaaa acataaggag    660 

ttggagggga ccagccaggc ttcagctgaa taccaagttt tgcagattgt gtcggcaatg    720 

gaaaactatg gcatagaatg gcattctgtg cgggatagcg aagggcagag actgctcatt    780 

ggggttggac ctgaaggaat ctcaatttgt aaagatgact ttagcccaat taataggata    840 

gcttatcctg tggtgcagat ggccacccag tcaggaaaga atgtatattt gacggtcacc    900 

aaggaatctg ggaacagcat cgtgctcttg tttaaaatga tcagcaccag ggcggccagc    960 

gggctctacc gagcgataac agagacgcac gcattctaca ggtgtgacac agtgaccagc   1020 

gccgtgatga tgcagtatag ccgtgacttg aagggccact tggcatctct gtttctgaat   1080 

gaaaacatta accttggcaa gaaatatgtc tttgatatta aaagaacatc aaaggaggtg   1140 

tatgaccatg ccaggagggc tctgtacaat gctggcgttg tggacctcgt ttcaagaagc   1200 

aaccagagcc cttcacactc gcctctgaag tcctcagaaa gcagcatgaa ctgcagcagc   1260 

tgcgagggcc tcagctgcca gcagacccgg gtgctgcagg agaagctacg caagctgaag   1320 

gaagccatgc tgtgcatggt gtgctgcgag gaggagatca actccacctt ctgtccctgt   1380 

ggccacactg tgtgctgtga gagctgcgcc gcccagctac agtcatgtcc cgtctgcagg   1440 

tcgcgtgtgg agcatgtcca gcacgtctat ctgccaacgc acaccagtct tctcaatctg   1500 

actgtaatct aatctgttgt gcttttgttg gacttggcat gtttccatga actgcactat   1560 

tataaactat taaaatgata gatgttggag aaagtaatta ttccaacacc catctgccca   1620 

tgcgatgtta aaaaa                                                    1635 

 
           
             84  
             2118  
             DNA  
             human  
           
            84 

ctgtgaagat ggcgctctcc agggtgtgct gggctcggtc ggctgtgtgg ggctcggcag     60 

tcacccctgg acattttgtc acccggaggc tgcaacttgg tcgctctggc ctggcttggg    120 

gggcccctcg gtcttcaaag cttcaccttt ctccaaaggc agatgtgaag aacttgatgt    180 

cttatgtggt aaccaagaca aaagcgatta atgggaaata ccatcgtttc ttgggtcgtc    240 

atttcccccg cttctatatc ctgtacacaa tcttcatgaa aggattgcag atgttatggg    300 

ctgatgccaa aaaggctaga agaataaaga caaatatgtg gaagcacaat ataaagtttc    360 

atcaacttcc ataccgggag atggagcatt tgagacagtt ccgccaagac gtcaccaagt    420 

gtcttttcct aggtattatt tccattccac cttttgccaa ctacctggtc ttcttgctaa    480 

tgtacctgtt tcccaggcaa ctactgatca ggcatttctg gaccccaaaa caacaaactg    540 

atttcttaga tatctatcat gctttccgga agcagtccca cccagaaatt attagttatt    600 

tagaaaaggt catccctctc atttctgatg caggactccg gtggcgtctg acagatctgt    660 

gcaccaagat acagcgtggt acccacccag caatacatga tatcttggct ctgagagagt    720 

gtttctctaa ccatcctctg ggcatgaacc aactccaggc tttgcacgtg aaagccttga    780 

gccgggccat gcttctcaca tcttacctgc ctcctccctt gttgagacat cgtttgaaga    840 

ctcatacaac tgtgattcac caactggaca aggctttggc aaagctgggg attggccagc    900 

tgactgctca ggaagtaaaa tcggcttgtt atctccgtgg cctgaattct acgcatattg    960 

gtgaagatag gtgtcgaact tggctgggag aatggctgca gatttcctgc agcctgaaag   1020 

aagctgagct gtctctcttg ctgcacaacg tggtcctgct ctccaccaac taccttggga   1080 

caaggcgctg aatgaaccat ggagcggatg gcattgtcct gcagtcgtat agtatagcag   1140 

tgcaggaaca aacagcactt gccagcaaag tctgtgtgta ctgttaagtg tgtgggaggc   1200 

agagagagga gcaggggcca tgggcttcac agcatggcac acctgtggga actgcagaca   1260 

ttcctctcac agctagaact gaaacaaacc ctcttgctag gggtggtccg tgtgaggtgt   1320 

catcctgtcc ccctcataat tactaatagc tggaactggc agcagcctct actgggcttt   1380 

tactgtgatg tgttcagttc atgtcctagg aagtcagctt ttgccccagg tgggaatcct   1440 

tatttggctt aggactgatc cacttccatg ttacttacat ctgtgggttt ttgttgttgc   1500 

tgttagaaaa tttttggctg gtgaaaacag cactcctttg gctggagcac ttgtgtccat   1560 

gcatgtactt gggtgtttcc ctccatcctt tctgatatga ccaaaaatca agttgttttg   1620 

ttttttgtca ccttcactgg catgggctaa ccacttcttt ttcaaaccct ctgaacacct   1680 

ttttctgatg ggtaacttgc aggaatattc tattggaaaa gataacagga agtacaagtg   1740 

cttcttgacc ccttcctcaa tgtttctagc cttcactctc cattgtcttt tctgggctgt   1800 

attacagccc tctgtggatc ttcaactctg ctgcctccac tgtgatgcag cagtccaact   1860 

gtaactgaca gtggctgcct tctctgggcc atggatcaca cctgtaaggt actaattact   1920 

gcccagcctg gggagatcag gagaggtctg catagttagt aagttgggtt tagcttttgt   1980 

gtgtgcatca gtgacttaga gttctgtaat aacttattgt aaatgcatga agcactgttt   2040 

ttaaacccaa gtaaagactg cttgaaacct gttgatggaa aaaaaaaaaa aaaaaaaaaa   2100 

aaaaaaaaaa aaaaaaaa                                                 2118 

 
           
             85  
             4221  
             DNA  
             human  
           
            85 

cgataacgat ttgtgttgtg agaggcgcaa gctgcgattt ctgctgaact tggaggcatt     60 

tctacgactt ttctctcagc tgaggctttt cctccgaccc tgatgctctt caattcggtg    120 

ctccgccagc cccagcttgg cgtcctgaga aatggatggt cttcacaata ccctcttcaa    180 

tcccttctga ctggttatca gtgcagtggt aatgatgaac acacttctta tggagaaaca    240 

ggagtcccag ttcctccttt tggatgtacc ttctcttctg ctcccaatat ggaacatgta    300 

ctagcagttg ccaatgaaga aggctttgtt cgattgtata acacagaatc acaaagtttc    360 

agaaagaagt gcttcaaaga atggatggct cactggaatg ccgtctttga cctggcctgg    420 

gttcctggtg aacttaaact tgttacagca gcaggtgatc aaacagccaa attttgggac    480 

gtaaaagctg gtgagctgat tggaacatgc aaaggtcatc aatgcagcct caagtcagtt    540 

gccttttcta agtttgagaa agctgtattc tgtacgggtg gaagagatgg caacattatg    600 

gtctgggata ccaggtgcaa caaaaaagat gggttttata ggcaagtgaa tcaaatcagt    660 

ggagctcaca atacctcaga caagcaaacc ccttcaaaac ccaagaagaa acagaattca    720 

aaaggacttg ctccttctgt ggatttccag caaagtgtta ctgtggtcct ctttcaagac    780 

gagaatacct tagtctcagc aggagctgtg gatgggataa tcaaagtatg ggatttacgt    840 

aagaattata ctgcttatcg acaagaaccc atagcatcca agtctttcct gtacccaggt    900 

agcagcactc gaaaacttgg atattcaagt ctgattttgg attccactgg ctctacttta    960 

tttgctaatt gcacagacga taacatctac atgtttaata tgactgggtt gaagacttct   1020 

ccagtggcta ttttcaatgg acaccagaac tctacctttt atgtaaaatc cagccttagt   1080 

ccagatgacc agtttttagt cagtggctca agtgatgaag ctgcctacat atggaaggtc   1140 

tccacaccct ggcaacctcc tactgtgctc ctgggtcatt ctcaagaggt cacgtctgtg   1200 

tgctggtgtc catctgactt cacaaagatt gctacctgtt ctgatgacaa tacactaaaa   1260 

atctggcgct tgaatagagg cttagaggag aaaccaggag gtgataaact ttccacggtg   1320 

ggttgggcct ctcagaagaa aaaagagtca agacctggcc tagtaacagt aacgagtagc   1380 

cagagtactc ctgccaaagc ccccagggta aagtgcaatc catccaattc ttccccgtca   1440 

tccgcagctt gtgccccaag ctgtgctgga gacctccctc ttccttcaaa tactcctacg   1500 

ttctctatta aaacctctcc tgccaaggcc cggtctccca tcaacagaag aggctctgtc   1560 

tcctccgtct ctcccaagcc accttcatct ttcaagatgt cgattagaaa ctgggtgacc   1620 

cgaacacctt cctcatcacc acccatcact ccacctgctt cggagaccaa gatcatgtct   1680 

ccgagaaaag cccttattcc tgtgagccag aagtcatccc aagcagaggc ttgctctgag   1740 

tctagaaata gagtaaagag gaggctagac tcaagctgtc tggagagtgt gaaacaaaag   1800 

tgtgtgaaga gttgtaactg tgtgactgag cttgatggcc aagttgaaaa tcttcatttg   1860 

gatctgtgct gccttgctgg taaccaggaa gaccttagta aggactctct aggtcctacc   1920 

aaatcaagca aaattgaagg agctggtacc agtatctcag agcctccgtc tcctatcagt   1980 

ccgtatgctt cagaaagctg tggaacgcta cctcttcctt tgagaccttg tggagaaggg   2040 

tctgaaatgg taggcaaaga gaatagttcc ccagagaata aaaactggtt gttggccatg   2100 

gcagccaaac ggaaggctga gaatccatct ccacgaagtc cgtcatccca gacacccaat   2160 

tccaggagac agagcggaaa gacattgcca agcccggtca ccatcacgcc cagctccatg   2220 

aggaaaatct gcacatactt ccatagaaag tcccaggagg acttctgtgg tcctgaacac   2280 

tcaacagaat tatagattct aatctgagtg agttactgag ctttggtcca ctaaaacaag   2340 

ctgagctttg gtccactaaa acaagatgaa aaatacaaga gtgactctat aactctggtc   2400 

tttaagaaag ctgccttttc atttttagac aaaatctttt caacgctgaa atgtacctaa   2460 

tctggttcta ctaccataat gtatatgcag cttcccgagg atgaatgctg tgtttaaatt   2520 

tcataaagta aatttgtcac tctagcattt tgaatgaata gtcttcactt tttaaattat   2580 

tcatcttctc tataataatg acatcccagt tcatggaggc aaaaaacaag tttcttgtta   2640 

tcctgaaact ttctatgctc agtggaaagt atctgccagc cacagcatga ggcctgtgaa   2700 

ggctgactga gaaatcctct gctgaagacc cctggttctg ttctgcctcc aacatgtata   2760 

attttatttg aaatacataa tcttttcact atgcttttgt ggggtttttt ttaagtatgt   2820 

gtaaaaatgt gatgctcaga taagtacatt tatatcagtt cagtgttaaa atgcagtctc   2880 

ttgagttaaa gtcatcttta ttttaaatgc agtgataaat gtcaactctt cggagaaact   2940 

aggagaacaa caacagaaag ctgtgtttgt cttttttctc tcaaatatat ctcccgtatg   3000 

agatttcagg tccccatgtt ttcaccaagc aatctgctat gtcagccaac ccaacatcac   3060 

tttctacagg aggttatgat ttttgccatt tactagagga agatgtttta tgaaatcaat   3120 

ttggggtttg aattcaggtg cagtcatcag ttctttaggg gctgcaatgt tttaaaaaaa   3180 

ataagtcatc agattttaag aaaaaagtga tgatttctta ttgatatttt tgtaacagaa   3240 

tatagctctt aactgaaaat ccagaaccag aaacataaat cttgagtttc ttttcatgta   3300 

cataaaaagc aatagccttt tagtatagat agccctgagc caaaaagtaa tagaattttc   3360 

tctagatatt taatacagag agtgtataga ctgactctaa gttaataatg tgcaaaatat   3420 

cttaaacatc cctcccctta ttcaacaatt atgtatcagt gatcttgaac cattgtttta   3480 

tatttttcac ctttgtaacc tcatggaaag aggctttaca tactttctat gtactattta   3540 

cttagaaggg agcccccttc cagtcatgaa acttcatttg ttttatccat atccctgagg   3600 

actgtgtaga ctttatgtca gttctgtgta gactttatgt cagtttttgt cattatttga   3660 

aaatctattc tgacaacttt ttaattcctt tgatcttata agttaaagct gtaacaactg   3720 

aaattgcatg gatcaagtaa gcatagtttt atccagggag aaaaataaaa ggaagccata   3780 

gaattgctct ggtcaaaacc aagcacacca tagccttaac tgaatattta ggaaatctgc   3840 

ctaatctgct tatatttggt gtttgttttt tgactgttgg gctttgggaa gatgttattt   3900 

atgaccaata tctgccagta acgctgttta tctcacttgc tttgaaagcc aatgggggaa   3960 

aaaaatccat gaaaaaaaaa agattgataa agtagatgat tttgtttgta tccctaccca   4020 

tctcctggca gccctactga gtgaaattgg gatacatttg gctgtcagaa attataccga   4080 

gtctactggg tataacatgt ctcacttgga aagctagtac ttttaaatgg gtgccaaagg   4140 

tcaactgtaa tgagataatt atccctgcct gtgtccatgt cagactttga gctgatcctg   4200 

aataataaag ccttttacct t                                             4221 

 
           
             86  
             867  
             DNA  
             human  
           
            86 

cgtttcagcg tggcggcgct ggtgctggcg ttggccctgg aggacggccc cgagtgatgg     60 

ctggcgcctg cctcccgggt gtctcccggg tacagatgga gtcgtcccgc ggccgccggc    120 

ggcaaggtcg gcagctgcga ggccaagaga gaccccagga cacacacagc tgcctcccgg    180 

tgcgagaaga agaccccggc ttgagagtga gatggcgttt aatgattgct tcagtttgaa    240 

ctaccctggc aacccctgcc caggggactt gatcgaagtg ttccgtcctg gctatcagca    300 

ctgggccctg tacttgggtg atggttacgt tatcaacata gcacctgtag atggcattcc    360 

tgcgtccttt acaagcgcca agtctgtatt cagcagtaag gccctggtga aaatgcagct    420 

cttgaaggat gttgtgggaa atgacacata cagaataaac aataaatacg atgaaacgta    480 

cccccctctc cctgtggaag aaatcataaa gcggtcagag tttgtaattg gacaggaggt    540 

ggcctataac ttacttgtca acaactgtga acattttgtg acattgcttc gctatggaga    600 

aggagtttca gagcaggcca accgagcgat aagtaccgtt gagtttgtga cagctgctgt    660 

tggtgtcttc tcattcctgg gcttgtttcc aaaaggacaa agagcaaaat actattaaca    720 

atttaccaaa gagatattga tattgaagga atttgggagg aggaaaagaa acctggggtg    780 

aatacttatt ttcagtgcat cattactgtt ccagattcct atgatggatg gcagactctt    840 

taataaattg cttactgata ttatctt                                        867 

 
           
             87  
             561  
             DNA  
             human  
             
               misc_feature  
               (534)..(534)  
               any kind of base  
             
           
            87 

tttttttttc aaattttatt ttttgtactt ttattgaaaa ggtacattta aaaaaataca     60 

cagacatttt accatttaca ggttgcagat atagatgctc taaaagagtc cactctattt    120 

tgttgttcta tgataactct tgcccctgat atcacaaaca ttccagtctt gttgatatcg    180 

gcttaaaaag gggggcatgg gagcatgacc tgcaatatat tcagcgaaca gaaagacaaa    240 

ttgttcaatt ataaattttt ttatcttctg tacattattg cattagggag ccacaaaatt    300 

atgtagcatc attacaaatg aaaacaggtt aaaaatgaag aagatactta tatagaaata    360 

catggattca ttgtcttctt gcagaatgca caagaggtgc aaaaatgtgc aatttaggaa    420 

gctctttttc tgtttgtata cgtttgctta gcaacacaaa ccagtgagga agctacaaaa    480 

taagttaaac aaaaatagca aacaggtagt aattatagct atgttatatg gctntctatt    540 

tcatttaaat atctccaaat a                                              561 

 
           
             88  
             471  
             DNA  
             human  
           
            88 

tttcatgaat aattttattt ttattttggt catgactttt taaaattaat ggaaagtctc     60 

agtctgctca aatgataaac caaaaaatgg ggtcatgaag caaattcagt ctttgcattt    120 

cttcaacaac caactcacat ttctctgctc cttgactcag aggctggaca tgtgctaaca    180 

gcttttttgc ttctgtatat ccttaatagg atggcagaat cccggtgtta aaagaatctt    240 

aaagtcagcc gtgtcaccat gggacctcga ttagcaaaca gatgtagaca ttccttccaa    300 

attcagtcaa agaaaaaact ctaataccag cagccatgtt cagggtgtgc acgacatgct    360 

gagcgcttgg gatacatccc cttgtttaat tctcacagaa actttgtgag acaagtacta    420 

taatccctgt ttaacagatg ggcaaactga ggtttggaaa aacactcatt t             471 

 
           
             89  
             727  
             DNA  
             human  
           
            89 

taaaatatta ccttttattt tctcaggcac acaagtgatt tggataccaa ttatcaagac     60 

attttactga tttcccttta gaatgatcta ttttaaatct tcagccacct tagaaaaagt    120 

ttgcagcaat cactttgcaa ttcataagta tcaggttaga atttagttgt ggaataagtt    180 

aacagtttat gttcaatatg tgaggttatt tgaactcctg agttttaaat atcctgtgga    240 

acagtgattc ctctcccttc taatggcttt tcagattaaa gcaatgactt taaaaagatt    300 

acatcctaaa tacttgatta caacagaaat cgaccaatct aaaaatcaga tagtgttata    360 

ctgaacatca ttctgatata atgagtagcc tctggctgaa acaaaattcc accaccaagg    420 

ccatcaacca ggttagtact gtttttcctg gggtctatgt aaactctcct tttctctgca    480 

aatgctgctt ggctgtgaac agcatggatt tacctgcacc aatgtggcac acacctagca    540 

actttctcaa gcattctaaa gatatcccca gagctacaat attgacatat gcacagcact    600 

ttctctagac agtccaatca gcgtgcacat cacacacaca gaatgctggg atatgctata    660 

ctgcacactt agtacacagg tggaatagag tacaatgact aaagctcaca gaaaatgttt    720 

tagtctt                                                              727 

 
           
             90  
             460  
             DNA  
             human  
           
            90 

tttttgatat aaagggcttt tattttcttt acagttttct gtattttcca aatttctaca     60 

taaacataca cataaaagtc ataaaaatgt ccctcaaaat gacactccct ccaatgcagg    120 

gagtgaggag gtgtgtgctg ggacgccaca gggtggctgc tgcagctaat ccctgtgcag    180 

gtgcagccac tgctacactc cagcgtctga ggcccctctg cactggcagt gttagaatgg    240 

ctgtctgaga gccaaggctg ttcacccgag cagagagtca tggagctggt acaggcagga    300 

gccaaggtaa gcactaggct ggtgtgtgcc ctccaggggg caccctcctt gaagcaggcc    360 

ctccaaggta ctcgccccct gaggcagccg ataacagccg gaagccttcc cctgggggga    420 

cctggccatt tgtggagcag ggaaaggctc cactgccagt                          460 

 
           
             91  
             392  
             DNA  
             human  
           
            91 

tttttttttt tttttttgag ttgctgaaaa gtttactttt gagttttaaa ctgtactttg     60 

aaaactatat tgtgaactgt gttgacatga ggaaaggctg ggctccctga aaacatccag    120 

ttccacagca gggcgggccc aagcccagcc aatccccagg caatgcaggg cagggatccc    180 

acctggtata agtacgggca gagggcagag ccaggctgta tcgaggggcg gcgctgggac    240 

cctcctcgcc cagaattcct actcatcccc agcacagaag tgctctgtag ggccagctga    300 

ggacaccccg gttcactgag ggtggcccac agtaagtcgc cgtctggcag taagttagct    360 

ctgcaggtgt ggaccccaag accacacacg gc                                  392 

 
           
             92  
             496  
             DNA  
             human  
           
            92 

ttttttgtat ttttctcaat ataatgttgc aagatgtcat tatattctca ttacccataa     60 

cttcccatcc aaatcttaat ggcacatttg atattttttc aaatggcttt gagatataat    120 

tcacatacca cacaattcat gtatctaaag tatacagttc tgtagttctg tggttgttgg    180 

ttacatccac cagactgagg gctccctgag ggttggtgcc tcagctttcc cttcacttac    240 

tcattcacca aacattcagc gcctactgag tactggggtt atgatggcca acaggagaga    300 

cagtctctgc ctactgtttg gtgggggtgg agtacttagt aaccgtcgtc attattgagt    360 

gcttacctgt gctgggcaca gtgctgctac tgggtgactg tgtccccagg gctgtcccag    420 

gctgggggtc tggaggagta gttatcagtt gaactgagtt aatccacagt ggaaggtaac    480 

ccactccctg ccctag                                                    496 

 
           
             93  
             472  
             DNA  
             human  
           
            93 

ttaacacaaa agcttttact tggaaactgg caaatactgg actagaatac tgacatgctc     60 

acgctctggc gggagctcgg atgcagaagc tattgcacaa agcccctctg attgccttgc    120 

tcctctttgg catgtatcag cagagcccca agggccaatt gcccacaggt ggggactgtt    180 

ctccatcaag gtatggggac ccctacttcc ttgttttgtt aaaaagtgca ggtaggcgaa    240 

gaaagcccag gcagttgacc cagtctttga aacagctgac tccccagagc tggggccagg    300 

ggagcctggt cttgaggggt aagggctgca gggccaggct gatggcctgt gtcatggcat    360 

tggccatctc ctctccagct tctcctcagc catcgcccgt ccgtcatggt ggtgtcggct    420 

gcacctggac cttcctgcct ctccgctcag ggcagcagca gtgagtgcag ca            472 

 
           
             94  
             585  
             DNA  
             human  
           
            94 

tttttatatt atagtaaatt tatttggtat aattacatat taacattatt tacaatgcta     60 

atttttttat ttataaagta tctttatatg gacaaaaaga tacaaactgt tatcatttta    120 

agtacaaagt atttctagaa atacattata agccattaaa aaaaaaaacg atatttcaag    180 

attggttctt acatgctatg accaactcat atgaaagagc aagttgctcc cccttcattc    240 

cttcccccaa ctccaaaggg aaaggaattt gatatttagg ctttaaaaaa tttcctacta    300 

cctttatctt ttaaaaaacc ctactcaaaa caactatctc ttataaggga aaatatcata    360 

gataagattt tcctttagaa aatgacatta aaagtggcat gagccctaga atgatatgtg    420 

tattagaggc acttaaaaaa aatcagaagg gatccatagg aaggaattta attcagcaaa    480 

tactgagtgt ccactgcatg caaggtaccc tgccagaaat ctcaaatgag taagttgtcc    540 

ttagggatag aaggtgctaa gcatcatgca aaagatatga actga                    585 

 
           
             95  
             400  
             DNA  
             human  
           
            95 

ttattgtttt ttaaaaatac aattttgaaa tttattgttg aaaatggaca catggaacaa     60 

accaaacctt gttttatcat gtaattttca gaaaatatgt gatccataaa gattaaaaga    120 

aagttgtatt aagtctggca gctttagtat taacttgaaa taaaatatgg caagctttcc    180 

acgtcctcct ttatttccac aatccatatg tacgagctag attccagtca gaacttccac    240 

aaatacttca ctctttggta gcagcggtta taaattacgc ctttgctaat ttgcgttgtt    300 

cccaaccagg agaaacatta ccacaaaaaa agtcagtttc atcctgcagt gttcccgcag    360 

caaccatatt aaagctgaag aataaagctc ctttgtagta                          400 

 
           
             96  
             461  
             DNA  
             human  
           
            96 

ttatgccatg aattcctttt tactgaaata ccgtaggact cactaccaca ataagtactt     60 

aagctgaaag agtttctaat gggagccaag taaattcagc tctccactgt gcaaagcatc    120 

ttgtcatttc tataataaaa gtctttccat gttcagtcca ctttggctct ggaacctgga    180 

tgagtcatgc ttggggccca gggtgcctgt gaggatgctg catgagaatt tcagctgtgg    240 

tggcagtggc tgggagtccc actgactcag ggggaggcca ggcgagatga gctggaactt    300 

ttaggggaga gctggcactt agggacatca ttgattgtgc ttttcttagc ctagttctgt    360 

cctgcaattt atttttctta tcatgtgact gtcggctgaa gtctggggtt atttggtttc    420 

tttttcttct tccttgctgg acagtctcca tggggtcacg g                        461 

 
           
             97  
             542  
             DNA  
             human  
           
            97 

taaatccagt aaagcatagt actagattca tcatacttgt acaatacaac gggcgacatg     60 

aaaatggcaa aggctctcct ttttgtgaac aatttaatac aactggtggt ccaataactc    120 

tacaatcagc cttgtagagg tcattaaaga cagaatcctg aaagtccgtg actacaaata    180 

cattttcaaa ttccggagaa tccaaacctt caaattcttc cactgactcc atctttacaa    240 

agcccacttt aatgtccttt aaggctttta taagttcttc ttgttttcca gcttcttgaa    300 

ccaatatcac tcttgtttca atctgaggca tctcttcttc tacatatgaa gtagatccaa    360 

taagtaagtt ttccttggaa atctcagtaa ctttagaatc aaaaatggaa gagtctgcca    420 

agctagtcct cccagtagtg gatgttaata cactattttc agccatgatt tgtattcttc    480 

taaatcagca ctctcaaaaa agccctagga gttccacctc ttcaaacgcc gactcctctc    540 

ac                                                                   542 

 
           
             98  
             1017  
             DNA  
             human  
           
            98 

atgggcacct ggcttctggc ctgcacctgc gtctgcacct gtgtctgctc gggagtctct     60 

gtctcagggg atggacgagg gccaagggct ggaacctcca cctgcctcac caacaacatt    120 

ctcaggattg attgccactg gtctgcccca gagctgggtc agggctccag ccccgggctc    180 

cccttcatca gccccgtggt gctgacacat gcccttttca gcaaccaggc tgctggtggc    240 

acacagaagt gcatctggca gggcagtgag tgcactgtag tgttgccgcc caaggcagca    300 

ctcctgccat ctgacaattt catcatcact ttctaccact gcatgtccgg gagggatcag    360 

agcacgtcag ctcgccactg catcctgacc tggagcctca gtcctgcctt ggagtcaatg    420 

accacacttc tcagctatga gctggacttc aagaggcagg aagaggcctg ggagcgggcc    480 

cagcacaggg atcacattgt cggggtgacc tggctcatac ttgaagcctt tgagctggac    540 

cctggcttta tccttgaggc caggctgcgt gtccagacgg ccatgctggg ggatgacggg    600 

gcacaggagg agcgagggga gccagcccat gggaagagtg aggcccagga gtgtggttca    660 

cacaaggtcc ttcagcaggt gacacaaacc tccaaggccc atcacaaggt ccttcagcag    720 

atgacacaaa cctccaaggc tcatcacaaa ccttccactt tggcccaggg cactaaaggg    780 

cgcacttttg ccagccctgg gcccttcctg cccacggacc ctctgatccc accctggggg    840 

tggccaggca acacctttgt tgctgtgtcc atctttctcc tgctgactgg cccgacctac    900 

ctcctgttca agctgtcgcc cagactcctc actttgggca aaggacaaga agcaactcgg    960 

atgggggccc acagggctgg tgtgctgctg agccaggact gtgctggcac ccgatga      1017 

 
           
             99  
             1099  
             DNA  
             human  
           
            99 

agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct     60 

tcctcaccct gtccgtgacg tggattggtg agaggggcca tggttggggg gatgcaggag    120 

agggagccag ccctgactgt caagctgagg ctctttcccc cccaacccag caccccagcc    180 

cagacaggga gctgggctct tttctgtctc tcccagcccc actccaagcc cataccccca    240 

gcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccc tcccacttac    300 

cccagaactt tctccccatt gcccagccag ctccctgctc ccagctgctt tactaaaggg    360 

gaagttcctg ggcatctccg tgtttctctt tgtggggctc aaaacctcca aggacctctc    420 

tcaatgccat tggttccttg gaccgtatca ctggtccacc tcctgagccc ctcaatccta    480 

tcacagtcta ctgacttttc ccattcagct gtgagtgccc aaccctatcc cagagacctt    540 

gatgcttggc ctcccaatct tgccctagga tacccagatg ccaaccagac acctccttct    600 

tcctagccag gctatctggc ctgagacaac aaatgggtcc ctcagtctgg caatgggact    660 

ctgagaactc ctcattccct gactcttagc cccagactct tcattcagtg gcccacattt    720 

tccttaggaa aaacatgagc atccccagcc acaactgcca gctctctgat tccccaaatc    780 

tgcatccttt tcaaaaccta aaaacaaaaa gaaaaacaaa taaaacaaaa ccaactcaga    840 

ccagaactgt tttctcaacc tgggacttcc taaactttcc aaaaccttcc tcttccagca    900 

actgaacctc gccataaggc acttatccct ggttcctagc accccttatc ccctcagaat    960 

ccacaacttg taccaagttt cccttctccc agtccaagac cccaaatcac cacaaaggac   1020 

ccaatcccca gactcaagat atggtctggg cgctgtcttg tgtctcctac cctgatccct   1080 

gggttcaact ctgctccca                                                1099 

 
           
             100  
             1095  
             DNA  
             human  
           
            100 

ccaagcttac cacctgcacc cggagagctg tgtcaccatg tgggtcccgg ttgtcttcct     60 

caccctgtcc gtgacgtgga ttggtgagag gggccatggt tggggggatg caggagaggg    120 

agccagccct gactgtcaag ctgaggctct ttccccccca acccagcacc ccagcccaga    180 

cagggagctg ggctcttttc tgtctctccc agccccactt caagcccata cccccagccc    240 

ctccatattg caacagtcct cactcccaca ccaggtcccc gctccctccc acttacccca    300 

gaactttctc cccattgccc agccagctcc ctgctcccag ctgctttact aaaggggaag    360 

ttcctgggca tctccgtgtt tctctttgtg gggctcaaaa cctccaagga cctctctcaa    420 

tgccattggt tccttggacc gtatcactgg tccatctcct gagcccctca atcctatcac    480 

agtctactga cttttcccat tcagctgtga gtgtccaacc ctatcccaga gaccttgatg    540 

cttggcctcc caatcttgcc ctaggatacc cagatgccaa ccagacacct ccttcttcct    600 

agccaggcta tctggcctga gacaacaaat gggtccctca gtctggcaat gggactctga    660 

gaactcctca ttccctgact cttagcccca gactcttcat tcagtggccc acattttcct    720 

taggaaaaac atgagcatcc ccagccacaa ctgccagctc tctgagtccc caaatctgca    780 

tccttttcaa aacctaaaaa caaaaagaaa aacaaataaa acaaaaccaa ctcagaccag    840 

aactgttttc tcaacctggg acttcctaaa ctttccaaaa ccttcctctt ccagcaactg    900 

aacctcgcca taaggcactt atccctggtt cctagcaccc cttatcccct cagaatccac    960 

aacttgtacc aagtttccct tctcccagtc caagacccca aatcaccaca aaggacccaa   1020 

tccccagact caagatatgg tctgggcgct gtcttgtgtc tcctaccctg atccctgggt   1080 

tcaactctgc tccca                                                    1095