Abstract:
A method for wound-healing is disclosed where the method comprises providing a housing forming a cavity, the cavity comprising at least one opening configured to encompass at least a portion of a wound region of a patient. The method includes sealing a perimeter of the at least one opening to a surface of the patient proximate the wound region and absorbing a wound fluid in the cavity. A chamber is provided in communication with the cavity, and would fluid is electrochemically removed from the cavity into the chamber.

Description:
RELATED APPLICATIONS 
       [0001]    This application is a divisional of, and claims priority to, U.S. patent application Ser. No. 11/958,303 filed on Dec. 17, 2007 and entitled “ELECTROCHEMICAL WOUND THERAPY DEVICE,” which was a divisional of, and claims priority to, U.S. patent application Ser. No. 10/657,820 filed on Sep. 8, 2003 and entitled “DEVICE AND METHOD FOR WOUND THERAPY,” which application issued as U.S. Pat. No. 7,361,184 on Apr. 22, 2008. These applications and patent are hereby incorporated by reference. 
     
    
     BACKGROUND OF THE INVENTION 
       [0002]    1. Field of Invention 
         [0003]    The invention relates in general to a method for wound therapy that is capable of treating a variety of wound types, including infection wounds, burn wounds, diabetic ulcers, post amputation wounds, surgical wounds, and the like. Specifically, the present invention is related to wound treatment methods that utilize negative pressure therapy. 
         [0004]    2. Background Art 
         [0005]    The concept of using negative pressure in the treatment of wounds has been around for decades. For example, some recent U.S. patents, including U.S. Pat. Nos. 5,636,643, 5,645,081 and 6,142,982, describe a number of different types of negative pressure wound healing equipment. The equipment described and disclosed in the prior art, however, is bulky and requires complicated associated equipment such as suction pumps, vacuum pumps and complex electronic controllers. Thus, the present devices that utilize negative pressure therapy are bulky, power intensive, costly and non-disposable. 
         [0006]    It is therefore an object of this invention to provide a negative pressure wound therapy device that is self-contained and entirely disposable after use. 
         [0007]    Additionally, it is also an object of this invention to provide a device and method for creating a negative partial pressure without the use of electrically/chemically powered suction and/or vacuum pumps. 
         [0008]    It is also an object of this invention to provide a device and method for creating a suction environment around a wound, without the need for electrically-produced suction or the use of a vacuum pump. 
         [0009]    These and other objects will become apparent to one of ordinary skill in the art in light of the specification, claims and drawings appended hereto. 
       SUMMARY OF THE INVENTION 
       [0010]    The present invention includes a disposable, self-integrated wound therapy device that does not require an external power source. The device includes a gas or fluid impermeable housing with a cavity having at least one opening. The housing also includes at least one of an oxygen absorber/remover or a fluid absorber/remover. The housing may further include an antimicrobial porous fluid absorbing material within or adjacent the cavity. In one embodiment the device includes a sensor to detect the pressure or oxygen level over the wound and within the cavity. In another embodiment the device further comprises means for filling the cavity of the housing with oxygen or fluid before the device is activated. 
         [0011]    In a preferred embodiment, the device comprises a disposable device having a cavity capable of encircling and sealing over an area of wound to be treated on the patient. In such embodiment, the cavity further comprises a fluid absorbing antimicrobial porous pad, oxygen absorber or oxygen remover, each of which is capable of creating negative pressure over or within the wound region. The oxygen absorber or remover can be either a chemical absorber or an electrochemical cell. In case of electrochemical cell, an associated electronic circuit may be incorporated to actuate the cell. 
         [0012]    The chemical absorbers could include any number of materials that absorb or adsorb oxygen upon contact, but specifically may include metal powders, activated carbon, catalyst materials, zeolites and mixtures and combinations thereof. Similarly, any number of electrochemical cell types may additionally be used, as long as they consume oxygen as a part of their operation. For example, metal/air cells such as zinc/air, magnesium/air, aluminum/air, and iron/air cells may preferably be used with this invention. Additionally, a Nafion-based cell may also be used. 
         [0013]    In another preferred embodiment the device comprises a disposable device comprising a cavity capable of encircling and sealing over an area of the wound to be treated on the patient. In such embodiment the cavity further comprises either a chemical or electrochemical based fluid removal system or fluid absorbing system. The disposable device further comprises means for filling the cavity with fluid before activation of the device, such as an antimicrobial fluid hydrogen peroxide, water and the like. 
         [0014]    In another preferred embodiment, the wound therapy device may include materials for absorbing a fluid within the cell, such as an antimicrobial fluid absorbing porous pad placed in communication with the wound and at least partially enclosed within the cavity of the housing. The porous material can include, for example, an adhesive mesh, or a super-absorbent polymer material. Alternatively, in another embodiment, the porous pad may be external to the device itself; and a capillary or other similar fluid conduit can be placed into contact with wound fluids on one end and the absorbing materials on the other. 
         [0015]    The housing may be constructed from a number of materials, as long as they are fluid-impermeable, including steel, aluminum, copper alloys, and dense plastics such as polypropylene, polyvinyl chlorides, polyethylene, berex, nylon and Teflon. 
         [0016]    In another preferred embodiment the device further comprises means for heat generation during oxygen removal or absorption/adsorption. 
         [0017]    As an alternative to the above devices, pressure bands could be utilized to help close open wound regions instead of, or in conjunction with the negative pressure treatment devices. These bands would be placed on either side of a wound region, and create a downward pressure into the patient&#39;s skin. Alternatively, the pressure bands could provide a pressure that, either directly or indirectly, forces the edges of the open wound region towards one another. The amount of pressure to operate such bands would depend upon the particular application, but could be, for example, around 350 mmHg. 
         [0018]    Preferably, a fluid-absorbing means is placed above the wound region, and used in conjunction with the pressure bands. 
         [0019]    The invention further comprises a method for treating a wound comprising the steps of providing a gas impermeable housing having a cavity, positioning at least a portion of the wound within a cavity of the housing and one or both of the steps of absorbing the oxygen within cavity of the housing and generating a partial vacuum within the cavity. 
         [0020]    In an embodiment wherein the method of treating the wound comprises the steps of providing a non-permeable housing having a cavity, positioning at least a portion of the wound within a cavity of the housing and both of the steps of removing the oxygen from the cavity electrochemically, manually or chemically and generating partial vacuum within the cavity. 
         [0021]    In another embodiment wherein the method of treating the wound comprises further the steps of providing a housing having a cavity, positioning at least a portion of wound within a cavity of the housing one or both steps of first filling the cavity with oxygen before activating the manual, chemical or electrochemical cell to remove or absorb the oxygen from the cavity and secondly, generating controlled vacuum within the cavity. 
         [0022]    In another alternative embodiment wherein the method of treating the wound includes the steps of providing housing having a cavity, positioning at least a portion of the wound within a cavity of the housing, and the steps of first filling the cavity with fluid such as water removing the fluid (water) from the cavity and then using osmotic or electrochemical or electro-osmotic cell and thereby generating a controlled vacuum within the cavity. 
         [0023]    In another preferred embodiment, the method further comprises the steps of providing oxygen to the wound cyclically by providing an impermeable housing having a cavity, positioning at least portion of the wound within a cavity of the housing and the steps of first removing the air or oxygen and then filling back with air or oxygen in the cavity in a periodic way and generating cyclic pressure of oxygen over the wound. 
         [0024]    In an alternative embodiment of the present invention, negative pressure therapy can be undertaken by reducing pressure within the wound itself. To that end, one embodiment of the present invention may include a disposable wound therapy device that has a housing with a cavity therein, along with a perimeter surrounding the cavity, and means for removing wound fluid out of a wound region, which removing means is integrated into the housing. Such a removing means could include a super-absorber polymer object, capable of drawing fluid out and away from the wound region, such as to an external reservoir region, thus causing a suction environment surrounding the wound. This embodiment could operate with or without oxygen removing means. 
         [0025]    If the pressure-band embodiment of the present invention is used, the wound region is treated by the method including the steps of placing at least two pressure bands on opposite sides of a wound region of a patient, and applying pressure to the tissues surrounding the wound region using the pressure band, thereby forcing the one side of the wound region towards the other, to, in turn, close the wound region. Additionally, it may be beneficial to include the step of removing excess wound fluid from the wound region using a fluid absorbing or fluid removing means, such as a capillary conduit or an absorbent polymer. Furthermore, utilizing the pressure bands with the sealing patch, to cause a sub-atmospheric vacuum around the wound region, can provide additional benefits. 
         [0026]    It may likewise be beneficial to attach the pressure bands together, or to use an adhesive strip across the wound region, so as to force the walls of the open wound region towards one another. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0027]      FIG. 1  comprises a cut-out view of one embodiment of the wound-healing device; 
           [0028]      FIG. 1A  comprises cut-out view of the wound-healing device, incorporating an oxygen injection device; 
           [0029]      FIG. 1B  comprises still another cut-out view of the wound-healing device, having a sponge; 
           [0030]      FIG. 1C  comprises a cut-out view of the wound-healing device incorporating capillary tubes; 
           [0031]      FIG. 2A  comprises a cut-out view of the wound-healing device, incorporating an electrochemical cell; 
           [0032]      FIG. 2B  comprises another cut-out view of the wound healing device with an electrochemical cell, additionally incorporating an oxygen sensing device; 
           [0033]      FIG. 3A  comprises a cut-out view of the wound-healing device, incorporating an osmotic cell; 
           [0034]      FIG. 3B  comprises a cut-out view of the wound-healing device, incorporating an electro-osmotic cell; 
           [0035]      FIG. 4  comprises a cut-out view of the wound-healing device, which is resiliently deformable, incorporating a second adjacent fluid retention chamber; 
           [0036]      FIG. 5  comprises a cut-out view of one embodiment of the wound-healing device; 
           [0037]      FIG. 5A  comprises a cut-out view of the wound-healing device, incorporating a fluid-removal device; 
           [0038]      FIG. 5B  comprises a cut out view of another preferred embodiment of the wound-healing device, comprising a single fluid-absorption device; and 
           [0039]      FIG. 6  comprises a perspective view of a pressure-band embodiment of the present invention. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0040]    While this invention is susceptible of embodiment in many different forms, there is shown in the drawings and described herein in detail specific embodiments with the understanding that the present disclosure is to be considered as an exemplification of the principles of the invention and is not intended to limit the invention to the embodiments illustrated. 
         [0041]    Referring now to the enclosed figures and in particular to  FIG. 1 , wound therapy device (herein after “device”) is shown generally as  10 . Such a device is particularly useful in association with the therapy of surface wounds on a patient. These wounds may include, but are not limited to, infectious wounds, burn wounds, diabetic ulcers and wounds, post surgical wounds, bed source wounds, and the like. Additionally, such devices are contemplated for use in a variety of the fields, as would be contemplated by one or ordinary skill in the art. 
         [0042]    Disposable device  10 , as shown in  FIG. 1  comprises gas-impermeable rigid housing  102 , means  104  for absorption of oxygen from cavity  130 , means  106  for absorption of wound fluids, and means  108  for sealing the device along a perimeter  116  of device  10 . It is contemplated that the device  10  is not only disposable in its entirety but also very light and inexpensive. It is also contemplated that the device is shaped like a bandage, which can then be changed by the user multiple times. 
         [0043]    Sealing means  108  can comprise a number of different structures. Preferably, sealing means  108  comprises sealing disc  132  with pull tab  133 . Alternatively, sealing means  108  could also include adhesive, or another element that will create a substantially air-tight seal around perimeter  116  of device  10  upon operative positioning of same. The air-tight seal protects the contents of cavity  130  during storage and/or transportation of device  10 . 
         [0044]    In the embodiment incorporating sealing disc  132  for sealing means  108 , pull tab  133  operates to break the seal around perimeter prior to use of device  10 . Once sealing disc  132  is removed by using pull tab  133  the device may be placed on a patient&#39;s wound in such a fashion that cavity  130  incorporates the wound therein, and device  10  seals around perimeter of the wound. Housing  102  is preferably constructed from a rigid or semi-rigid type material so that it is capable of retaining a vacuum space surrounding the wound. As soon as the device is placed on the patient&#39;s wound, oxygen absorbing means  104  starts absorbing oxygen in the air around the wound, generating a vacuum within cavity  130 . At the same time, wound-fluid absorbing means  106  starts absorbing the fluids in the wound. Continued absorption of both the oxygen and wound fluid within cavity  130  creates a vacuum within cavity  130 , and surrounding the wound region. 
         [0045]    Sustained negative pressure over a wound region promotes tissue migration and wound closure. Device  10  is preferably shaped like a patch or bandage that may be changed more than once a day. During the time the device is on patient&#39;s wound, a negative pressure is generated due to the absorption of oxygen, thus the oxygen level around the wound is low (1-5%). When the device is removed after use the wound get exposed to 21% oxygen in air. Thereafter, another patch may be applied, reducing the oxygen partial pressure over the wound region. This alternate exposure of wound to oxygen level swings is also helpful in wound healing. 
         [0046]    Housing  102  may comprise any shape and is not limited to particular shape. Solely by way of example, and not to be limited thereto, housing  102  may be sized and shaped so that cavity  130  of device  10  and perimeter  116  of device  10  are capable of sealing over the patient&#39;s wound. Housing  102  is also designed such that it is capable of holding the vacuum when the device is plated and sealed over a patient&#39;s skin around the wound. 
         [0047]      FIG. 1A  shows the similar device as shown in  FIG. 1 , except that  FIG. 1A  device compromises one additional structure, namely means  110  for introducing oxygen into cavity  130 . Introducing means  110  allows a patient to introduce preferably pure or concentrated oxygen into the cavity, which is then absorbed by oxygen absorbing means  104 . This absorption, in turn, generates a stronger negative pressure over the wound of the patient.  FIG. 1A  additionally depicts device  10  as including antimicrobial fluid absorber  106  and capillary tubes  118 . Oxygen absorbers  104  are placed in the cavity  130  at two places as shown in  FIG. 1C . Device  10  shown in  FIG. 1C  allows the wound fluids to be pulled away from wound while simultaneously maintaining a negative pressure over the wound. 
         [0048]    The device shown in  FIG. 1D  is similar to the device shown in  FIG. 1C  except that, in  FIG. 1D , device  10  additionally includes oxygen introducing means  110  to, in turn, generate a stronger vacuum within cavity  130 . In  FIG. 1D , device  10  additionally comprises porous plastic antimicrobial sponge  106 , compared to the device shown in  FIG. 1C , which has a combination of capillary tubes  118  and antimicrobial sponge  106 . 
         [0049]    In all the above devices the vacuum is generated by using oxygen absorption means  104 . There are many chemical as well as electrochemical oxygen absorbers. For example, Mitsubishi Gas Chemicals manufactures Ageless® Z oxygen absorbers, which absorb oxygen through the oxidation of iron metal. Alternatively, small packets of oxygen absorbers and scavengers are available from Mitsubishi Chemical Corporation. Similarly, porous antimicrobial plastic for fluid absorption can be used, and are formed from composite materials made from absorbent plastics such as Polypropylene, polyethylene, and the like, as well as other materials such as silver oxide, metal peroxides, silver metal, and antimicrobial organic compounds. 
         [0050]      FIGS. 2A and 2B  depict similar devices to those shown in  FIGS. 1 ,  1 A,  1 B and IC in that they all are based on absorbing or removing oxygen from cavity  130  of housing  102 .  FIGS. 2A and 2B , however, include electrochemical cells  140  for absorbing or removing oxygen from within cavity  130 . In  FIG. 2A , disposable device  10  is shown as having housing  102 , fluid absorbing antimicrobial porous pad  106 , which is placed in cavity  130  of housing  102 , and oxygen sensor  112  to help gauge the negative pressure within cavity  130 . Preferably, electrochemical cell  140  is sealed onto housing  102  such that cell  140  is capable of either removing or absorbing the oxygen from within cavity  130 , generating a negative pressure therein. Cell  140  may be activated by electronic control circuit  142 . Control circuit  142  allows user to set a predetermined and desired negative pressure setting within cavity  130  for providing optimal wound treatment and therapy conditions for the wound. 
         [0051]    The device shown in  FIG. 2B  is similar to device shown in  FIG. 2A  except that in  FIG. 2B  device  10  additionally includes oxygen introducing means  110 , which is added to allow user to introduce oxygen into the cavity  130 , in turn enabling a strong negative pressure within cavity  130 . In the embodiment shown in  FIG. 2B , oxygen sensor  112  and electrochemical cell  110  are combined through control circuit  142  so that, once the desired level of negative pressure is reached within cavity  130  of housing  102 , electrochemical cell  140  stops operating, and thus consuming additional oxygen. By evaluating the oxygen level during operation, and controlling the operation of electrochemical cell  140  accordingly, the negative pressure within cavity  130  can be regulated to a desired level. There are many ways in which the elements of device  10  can be associated with, or placed within cavity  130 , with only exemplary embodiments and associations shown in  FIGS. 2A and 2B . 
         [0052]    U.S. Pat. Nos. 5,454,922, 5,607,572, 5,681,435, 5,707,499, 6,042,704, and 6,060,197 describe possible types of electrochemical cells that may be used for removing oxygen from within cavity  130 . For example, commercially available zinc-air cells can be used to remove oxygen. In one preferred embodiment, electrochemical cells  140  within device  10  could include either commercially available zinc-air cells, or any other metal/air electrochemical cells to remove oxygen from cavity  130  of housing  102 . 
         [0053]    The devices shown in  FIGS. 3A and 3B  are osmotic and electro-osmotic cell-based devices, respectively. 
         [0054]    As shown in  FIG. 3A , housing  102  in this embodiment incorporates an osmotic cell  120  that includes an osmotic membrane (such as Nafion® or any cation or anion membrane) in communication with antimicrobial sponge  106  placed within cavity  130  of housing  102  of device  10 . Osmotic cell  120  also includes saturated salt solution/or salt pellet  122  in chamber  124  so that fluids from sponge are pulled into osmotic cell  120  and stored in chamber  122 , thereby generating a vacuum within cavity  130  and over the wound. In this embodiment, and similar to oxygen introducing means  110 , device  10  includes water injection means  125  to introduce water into cavity  130  so that sponge  106  is saturated with water. Again as in other devices such as shown in  FIGS. 1 ,  1 A,  1 B,  1 C,  1 D,  2 A and  2 B, sealing means  108  is a sealing disc  132  which is pulled away by seal tab  133  before the device is placed on the wound of the patient. Many osmotic membranes are available commercially, any of which could be included in the present invention. 
         [0055]    The operation of the devices shown in  FIG. 3A  is simple. First, sealing disc  132  is removed by using pull tab  133 , and sponge  106  is saturated with pure water. The device is then placed on the patient&#39;s wound. Once in place, device  10  is activated. Within some minutes, the device begins to generate negative pressure within cavity  130  and over the wound. The device shown in  FIG. 3B  operates similarly, but requires the additional steps of activating electrochemical cell  140  so that cell  140  starts transporting the water from cavity  130  to chamber  124 . 
         [0056]    In  FIG. 3B , electrochemical cell  140  is a water removing cell, such as the cell shown and described in U.S. Pat. No. 6,491,684. 
         [0057]    The device shown in  FIG. 4  is manually operated. The device comprises housing  102  housing wall  103  that is elasticized, or “springy,” such that, when it is depressed by a user, it will squeeze and deform but return to its original shape, Many polymeric materials show these characteristics, if manufactured with the right dimensions and design characteristics. Housing  102  of device  10  shown in  FIG. 4  further comprises cavity  130  filled with antimicrobial porous fluid absorbing pad  106 . Housing  102  further comprises one way valve  150  sealed into housing  102  such that the fluid from cavity  130  can be squeezed out of cavity into a chamber  152  filled with antimicrobial fluid absorbing material  154 . Chamber  152  is attached to housing  102  as shown in  FIG. 4 . 
         [0058]    The operation of the device shown in  FIG. 4  is simple. First seal disc  132  is removed using seal tab  133 . Device  10  is then filled with water so that antimicrobial sponge  106  is completely saturated with water. Now the device is placed on patients wound and sealed along perimeter  116  of the device with adhesive, adhering perimeter  116  to the skin surrounding the wound to be treated. Once the device is firmly placed on the patient, the device is squeezed from its top by the application of pressure so that the water in sponge  106  is squeezed out through one way valve  150  into chamber  152 , which is filled with water-absorbing antimicrobial sponge  154 . Housing  102  then returns to original shape after squeeze. The removal of the fluid from within housing  102  creates a negative pressure over the wound. This negative pressure is controlled by the number of squeezing cycles. It is also contemplated that if the wound generates additional fluids during the treatment the squeezing can be done several times during the course of the treatment. 
         [0059]    One additional and related embodiment can be seen in  FIG. 5 . In prior embodiments, such as those shown in  FIGS. 1B ,  1 C, for example, fluid removing means  106  provides an additional aid in the use of negative pressure therapy that utilizes sub-atmospheric pressure, or a vacuum. Fluid-removing means  106 , however, can operate effectively without vacuum, as is shown in  FIG. 5 . In  FIG. 5 , device  10  is shown over wound region  160 , with capillary tubes  118  extending into wound region  160  itself. Capillary tubes  118  are connected with external reservoir  152 , and provide a conduit for the flow of fluid from out of wound region  160 , and into external reservoir  152 . By removing wound fluid from within wound region  160 , the internal pressure of the wound is decreased, and the wound region  160  is forced closed on itself, aiding healing. 
         [0060]    Device  10  is shown with capillary tubes  118  as a fluid delivery mechanism out of wound region  160  and into external reservoir  152 . Other embodiments and structures could similarly work as effectively, including using an alternative fluid delivery or removal means (such as an absorbent polymer strip overlying the wound region, for example, which simply absorbs the wound fluid, drying the wound and promoting healing (see FIG.  5 A)), or eliminating the fluid reservoir  152  altogether, such as through a one-way valve, The essential elements include removing the fluid from within the wound region so as to promote healing of that area. 
         [0061]    One especially preferred embodiment is shown in  FIG. 5B , in which the rubberized housing embodiment shown in  FIG. 1B  is combined with the fluid-absorbing structures of  FIGS. 5 and 5A . It is preferred that the fluid-removing means in  FIG. 5B  comprises a super-absorbent polymer material  106  that is flexible in design, and which is connected to an external reservoir  152 . Housing  102  includes a one-way valve  150 , and is flexible and elastic such that a user may depress housing  102 , releasing air from within housing  102 , and reducing the pressure within the cavity of the device. At the same time, the polymer  106  (or other fluid-removing means) is pulling fluid out of the wound region, and removing that fluid from within cavity. This embodiment combines external and internal negative pressure techniques. 
         [0062]    It should be noted that any of the above techniques for reducing the pressure within the cavity of the devices (i.e. through air/oxygen removal, or fluid removal), and within the wound itself (through wound fluid removal) can be beneficially combined for negative pressure wound therapy. 
         [0063]    In all of the above embodiments, where in the devices are disposable, these devices are capable of being discarded after use. The above teachings can be utilized with a wide variety of devices, and in any number of forms. For example, some contemplated devices into which the above teachings can be incorporated include a glove, a shoe insole, or a specialized sock. With these types of devices the patient can operate the device and receive proper treatment while undertaking other activities. In addition, after the treatment is completed, the user can merely dispose of the device. Indeed multiple disposable devices can be provided to patient to, in turn, provide a full treatment plan which consists of a plurality of individual treatments with disposable devices over predetermined period. 
         [0064]    One additional alternative embodiment is shown in  FIG. 6 . In  FIG. 6 , pressure bands  200 ,  200 ′ are placed on either side of a wound region  160 , and exert a pressure on the tissue surrounding the wound region  160 , pushing the perimeter  210  of the wound region closed, to in turn close the wound region. Such an embodiment may be combined with the oxygen-removing, fluid-removing, or wound-fluid removing embodiments discussed above. In any case, by pressing the wound region together, the healing of the wound region can be promoted. 
         [0065]    Pressure bands  200  can comprise any number of materials, including medical-grade elastic bands and the like, which are capable of being placed proximate the wound region of a patient, and of creating an approximately downward pressure on the skin of the patient. As shown in  FIG. 6 , pressure bands  200 ,  200 ′ basically comprise arm bands, surrounding the arm of a patient and pressing down on that arm. Alternative structures could function similarly, however, as long as the bands  200 ,  200 ′, through pressure on the surrounding tissues, promote healing by helping to close the wound region. 
         [0066]    One preferred way of aiding the closure of the wound region may be to include a connecting band or connecting means (not shown) between the pressure bands  200 ,  200 ′. Connecting means may be constructed from any rigid or elastic material that would exert a force between pressure bands  200 ,  200 ′, to pull those bands towards each other. The lateral movement of pressure bands  200 ,  200 ′, in combination with the approximately downward pressure of those bands, will provide an additional means to press the edges of the wound region together, in turn aiding the healing of the wound region. 
         [0067]    Alternatively, it may be desirous to include adhesive strip  220  over wound region. Adhesive strip  220  comprises a strip of material, such as a medical bandage, that is capable of being adhered to two sides of the wound region, and to pull those sides together. Similar to the connecting band or connecting means discussed above, adhesive strip  220  is preferably used in conjunction with pressure bands  200 ,  200 ′ to promote wound healing. 
         [0068]    Additionally, pressure bands  200 ,  200 ′ could be utilized with a number of the other structures discussed above, including but not limited to the fluid removing means or any other means for creating negative pressure inside or outside of the wound region. 
         [0069]    In operation, the pressure bands are provided  200 ,  200 ′ to a patient, and applied in opposing but surrounding positions to the wound region of the patient. The patient places the pressure bands around the wound, which bands then exert a pressure on the surrounding tissues for a period of time, preferably an hour or more, but most preferably for around 24 hours. The pressure that is exerted need not be significant, and preferably is around 350 mmHg of pressure. Once pressure is applied the wound region is at least partially closed, promoting healing. Preferably the pressure bands are combined with negative pressure therapy for maximum benefit. 
         [0070]    Preferably, in combination with the pressure bands, the wound region is at least partially closed by either connecting pressure bands  200 ,  200 ′ together to exert a lateral pressure (not downward) on the wound region, or adhesive strip  220  may be used to do the same. In either case, the healing of the wound region may be enhanced by physically closing the open wound area of the wound region. 
         [0071]    The foregoing description merely explains and illustrates the invention is not limited thereto except in so far as the appended claims are so limited, as those skilled in the art who have the disclosure before them will be able to make modifications without departing the scope of invention.