Abstract:
A system for radiotherapy includes a couch having a top lateral surface upon which a patient being treated by the system is positioned. The couch has continuous arc rotation for delivery of accelerated irradiation to the patient. The couch is movable rotationally and translationally. Delivery of the accelerated irradiation is performed during at least a portion of the movement.

Description:
[0001]    This application is a Continuation of application Ser. No. 12/930,348 filed on Jan. 4, 2011, which claims the benefit of U.S. Provisional Application 61/335,314 filed on Jan. 5, 2010, which is entirely incorporated herein by reference. 
     
    
     TECHNICAL FIELD 
       [0002]    The present invention relates generally to systems and methods for treatment and delivery of therapeutic radiation and, in particular, relates to a system and method for additional continuous arc rotation/shift of a couch (C-ARC) in the volumetric modulated arc therapy (VMAT) delivery of therapeutic radiation, as well as simultaneous kV cone-beam imaging for real-time treatment verification and adaptation. 
       BACKGROUND 
       [0003]    There are a number of known systems and method for treatment and delivery of therapeutic radiation. One of these is known as three-dimensional conformal radiation therapy (3D-CRT). 3D-CRT involves three-dimensional imaging, accurate radiation dose calculation, computer optimized treatment planning, and computer controlled treatment delivery. In particular, 3D-CRT uses computers and special imaging techniques such as CT, MR or PET scans to show the size, shape and location of a tumor as well as surrounding organs. The therapeutic radiation beams are then precisely tailored to the size and shape of the tumor with multileaf collimators or custom fabricated field-shaping blocks. The precise application of the therapeutic radiation beams results in nearby normal tissue receiving less radiation and so the normal tissue is able to heal more quickly after a therapeutic radiation session. The more normal tissue is shielded from receiving the therapeutic radiation allows for the amount of the radiation actually delivered to the tumor to be increased and so the chances of successfully treating the tumor increase. An example of 3D-CRT is described in the publication, Takahashi S, “Conformation radiotherapy: rotation techniques as applied to radiography and radiotherapy of cancer,” Acta Radiol 1965, Suppl. 242. 
         [0004]    Another system and method for treatment planning and delivery of therapeutic radiation is known as intensity-modulated radiation therapy, or IMRT. IMRT is a specialized form of 3D-CRT that allows radiation to be modulated, thus more exactly shaped to fit the tumor. In particular, IMRT involves breaking up the therapeutic radiation beams into many “beamlets.” The intensities of each beamlet are then adjusted individually. Such adjustment of intensities allows for the radiation received by healthy tissue near a tumor to be further reduced when compared with 3D-CRT. An example of IMRT is described in the publication, A. Brahme et al., “Solution of an integral equation encountered in rotation therapy,” Phys Med Biol Vol. 27, No. 10, 1982, pp. 1221-29. 
         [0005]    A third system for treatment and delivery of therapeutic radiation is known as intensity modulated arc therapy (IMAT) and later volumetric-modulated arc therapy, also known as VMAT. VMAT addresses several of the disadvantages of IMRT, namely, increased treatment time by requiring a larger number of beam directions and the use of increased monitor units (MU). VMAT addresses these disadvantages by allowing continuous gantry/collimator rotation, leaf motion, and dose rate adjustment for treatment plan optimization where dose is delivered during a single gantry arc of up to 360 degrees. The VMAT technique is similar to tomotherapy in that a full 360 degree range of beam directions are available for optimization, but is fundamentally different from IMRT in that the entire close volume is delivered in a single source rotation. An example of VMAT is described in: 1) Yu C. X. “Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy,”  Phys Med Biol  Vol. 40, 1995, pp. 1435-1449., 2) Yu C. X., et al., “Clinical implementation of intensity-modulated arc therapy,”  Int J Radiat Oncol Biol Phys  Vol. 53, 2002, pp. 453-463 and 3) Otto K., “Volumetric modulated arc therapy: IMRT in a single gantry arc,”  Med Phys  Vol. 35, 2008, pp. 310-317. 
         [0006]    VMAT involves, in part, using multileaf collimator (MLC) leaf motion and dose rate adjustment to modulate beam output intensity. In addition, VMAT delivers the modulated beam intensity output by rotating the gantry and collimator of a linac through one or more complete or partial arcs with the therapeutic radiation continuously on so that treatment times are reduced. During rotation of the gantry, a number of parameters can be dynamically varied, such as: i) the MLC aperture shape, ii) the fluence-output rate (“dose rate”), iii) the gantry rotation speed and iv) the MLC orientation. Being able to vary the parameters i)-iv) allows VMAT to reduce the need to use as many arcs, delivering fewer monitor units (MU) in a shorter time while providing dosimetry comparable to IMRT. While VMAT can take advantage of the above-mentioned four available variable parameters, it must do so while respecting the physical constraints of the linac and MLC—such as the maximum gantry speed, maximum leaf speed, the MLC orientation constraints and the available subdivisions of fluence-output rate. 
         [0007]    Without dynamically controlling all machine parameters, specifically the orientations between machine and patient, during treatment delivery, current VMAT technology is limited for certain treatment sites. In the case of breast cancer treatment, it has been shown that VMAT applied to treat left-sided breast cancers with internal mammary node irradiation resulted in an increase in the volume of lungs, heart and contralateral breast receiving low dose (5Gy) irradiation compared to modified wide tangents. By definition, due to its configuration, VMAT used for breast irradiation contains beams directed towards the heart, lungs, and contralateral breast. 
         [0008]    Another disadvantage of VMAT systems is that they do not integrate simultaneous kV imaging. Accordingly, such VMAT systems are not capable of real-time treatment verification 
       SUMMARY 
       [0009]    One aspect of the disclosure provides a system for radiotherapy including a couch having a top lateral surface upon which a patient being treated by the system is positioned. The couch has continuous arc rotation for delivery of accelerated irradiation to the patient. The couch is movable rotationally and translationally. Delivery of the accelerated irradiation is performed during at least a portion of the movement. 
         [0010]    In some examples, the couch has continuous translation for delivery of accelerated irradiation to the patient. The table is rotatable at least about a z-axis orthogonally extending through a lateral surface of the table. The radiation is delivered during at least a portion of the rotation about the z-axis. In some examples, the table is rotatable at least about a y-axis extending through a lateral surface of the table, and the radiation is delivered during at least a portion of the rotation about the y-axis. 
         [0011]    The system may further include an imaging system to generate image information that identifies an object of interest within the patient to be treated by the accelerated irradiation. Additionally or alternatively, the image information may be formed in a real-time manner during the continuous rotation of the couch. Such information may be used to control continuous rotation of the couch in a real-time manner. 
         [0012]    In some implementations, the image information may be formed in a real-time manner during the continuous rotation and translation of the couch. Such image information may be used to control continuous rotation and translation of the couch in a real-time manner. The continuous rotation and continuous translation of the couch may be based on image information of the patient generated prior to the patient being placed on the couch. 
         [0013]    Another aspect of the disclosure provides a radiation therapy system including a radiation source, a multi-leaf collimator, a table upon which the object is positioned, and a computer. The radiation source moves about an object and directs a beam of radiation towards the object. The multi-leaf collimator includes a plurality of moveable leaves that define an aperture through which the beam is directed from the radiation source to the object. The table is translationally and rotationally movable. The computer is in communication with the radiation source, the multi-leaf collimator and the table. The computer simultaneously controls one or more of the following parameters of the radiation source, the multi-leaf collimator and the table: table motion, radiation source motion, fluence output rate, multi-leaf collimator orientation, and shape of the aperture. The computer is configured to cause delivery of the radiation during at least a portion of the movement of the table. 
         [0014]    In some examples, the table is rotatable at least about a z-axis orthogonally extending through a lateral surface of the table. The radiation is delivered during at least a portion of the rotation about the z-axis. The table may be rotatable at least about a y-axis extending through a lateral surface of the table. The radiation is delivered during at least a portion of the rotation about the y-axis. In some examples, the table is rotatable at least about an x-axis extending through a lateral surface of the table, and the radiation is delivered during at least a portion of the rotation about the x-axis. 
         [0015]    The system may further include an imaging system to generate image information that identifies an orientation of the object. The image information may be formed in a real-time manner during rotational and translational movement of the table. Such image information is used to simultaneously control one or more of the following parameters in a real-time manner: table motion, table motion speed, radiation source motion, fluence output rate, multi-leaf collimator orientation, and shape of the aperture. Additionally or alternatively, simultaneous control of one or more of the parameters is performed based on image information of the object generated prior to a patient containing the object being positioned on the table. In some examples, the object is a tumor. 
         [0016]    Yet another aspect of the disclosure provides a method of providing radiation including directing a beam of radiation towards an object, defining an aperture through which the beam is directed to the object, and positioning a table having a top lateral surface upon which the object lies. The method also includes rotating the table at least about an axis thereof, wherein the beam of radiation is delivered to the object at least during a portion of the rotating. The method further includes simultaneously controlling, during the rotation, one or more of the following parameters: table motion, beam motion, fluence output rate, aperture orientation, and shape of the aperture. 
         [0017]    In some implementations, the rotation is about a z-axis orthogonally extending through a lateral surface of the table. In some implementations, the rotation is about a y-axis or an x-axis extending through a lateral surface of the table. In some implementations, the method includes translating the table along an axis thereof, wherein the beam of radiation is delivered to the object at least during a portion of the translating. 
         [0018]    The method may include generating image information that identifies an orientation of the object. The image information may be formed in a real-time manner during rotational and translational movement of the table. Such information is used to simultaneously control one or more of the following parameters in a real-time manner: table motion, beam motion, fluence output rate, aperture orientation, and shape of the aperture. The image information may be generated prior to a patient containing the object being positioned on the table, and wherein the simultaneously controlling is based on the image information. 
         [0019]    The details of one or more implementations of the disclosure are set forth in the accompanying drawings and the description below. Other aspects, features, and advantages will be apparent from the description and drawings, and from the claims. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0020]      FIG. 1  shows an embodiment of a radiation therapy system that can perform C-ARC therapy in accordance with the present invention; 
           [0021]      FIG. 2  shows a flow chart of a possible process for operation of the radiation therapy system of  FIG. 1  in accordance with the present invention; 
           [0022]      FIG. 3  schematically shows a system for simultaneous kV/MV imaging in accordance with the present invention; 
           [0023]      FIGS. 4A-D  show reference digitally reconstructed radiographic (DRR) with beams eye view (BEV) images at gantry positions of 90°, 135°, 180° and 270°, respectively, for an Stereotactic Radiosurgery (SRS) treatment; 
           [0024]      FIGS. 5A-D  show kV and MV portal images at gantry positions of 90°, 135°, 180° and 270°, respectively, for an Stereotactic Radiosurgery treatment; 
           [0025]      FIG. 6A  shows an external view of a possible beam arrangement for breast tumor treatment in accordance with the present invention; 
           [0026]      FIGS. 6B-C  show external views of beam arrangements for known breast tumor treatment plans; 
           [0027]      FIG. 7A  shows an internal view of the beam arrangement for breast tumor treatment of  FIG. 6A ; 
           [0028]      FIGS. 7B-C  show internal views of the beam arrangements for breast tumor treatment of  FIGS. 6B-C , respectively; 
           [0029]      FIG. 8A  shows the Ipsilateral Breast % Volume v. Dose plots of various known treatment plans when compared with a treatment plan in accordance with the present invention; 
           [0030]      FIG. 8B  shows for the Ipsilateral Lung % Volume v. Dose plots of various known treatment plans when compared with a treatment plan in accordance with the present invention; 
           [0031]      FIG. 9A  shows representative axial dose distributions for a treatment plan for breast tumors in accordance with the present invention; and 
           [0032]      FIG. 9B  shows representative axial dose distributions for a VMAT treatment plan. 
       
    
    
     DETAILED DESCRIPTION 
       [0033]    As shown in  FIG. 1 , there is shown a radiation therapy system  100  that can include an imaging system, such as a cone beam computed tomography system  102 , and a therapeutic radiation source, such as medical linear source or accelerator  104 . The computed tomography system  102  includes an x-ray source  106  and a flat panel imager  108  mounted on gantry  110 . The details of the computed tomography system  102  is described in U.S. Pat. Nos. 6,842,502 and 7,471,765, the entire disclosures of each of which are incorporated herein by reference. Of course, other types of imaging systems, such as C-arm support cone beam systems and proton imaging systems, can be used without departing from the spirit of the present invention. 
         [0034]    The system  102  is retrofitted onto an existing or new radiation therapy system  112  that includes a separate radiation therapy source, such as the medical linear source  104 , which operates at a power level to allow for treatment of a target volume in an object, such as a human patient. The medical linear source  104  generates a beam of x-rays or particles, such as photons, protons or electrons, which have an energy ranging from 4 MeV to 25 MeV. Indeed, the medical linear source  104  could be replaced with other radiation sources used for therapeutic treatment of patients without departing from the spirit of the present invention. The radiation therapy system  112  further includes a multi-leaf collimator (MLC)  113  that is movable as a unit and includes leafs that are movable so as to define an aperture for the therapy beam to pass through on to the patient. The radiation therapy system  112  may also include an imager (not shown) that is aligned with the medical linear source  104  with the patient interposed therebetween. 
         [0035]    For support of the patient and for aiding in the application of the therapeutic radiation beam, a computer-controlled treatment table  114  is provided. The table  114  is controlled by a computer, such as computer  116  schematically shown in  FIG. 1 . The table  114  allows translation of the patient in the x, y, and z directions as well as rotation about the x, y and z axes. Furthermore, the treatment table  114  is preferably constructed of radio-translucent material so as not to interfere significantly with the acquisition of computed tomography images. The table  114  can have many forms such as disclosed in U.S. Pat. Nos. 6,842,502 and 7,471,765 and U.S. Patent Application Publication No. US2010-0119032A1, the entire contents of each of which are incorporated herein by reference. 
         [0036]    The system  100  of  FIG. 1  is controlled by computer  116  so as to perform C-ARC therapeutic radiation treatment plans in accordance with the present invention. In particular, C-ARC, like VMAT, involves combining a modulated beam aperture and dose rate with rotational delivery. In contrast to VMAT, C-ARC introduces an alternative modality of delivering rotation. In particular, the table or couch  114  moves via translation and/or rotation so as to control therapeutic radiation delivery to the area of interest. Note that the translation of the table  114  can be in one or more of the x, y and z directions shown in  FIG. 1 . In addition, the rotation of the table  114  can be in about one or more of the x, y and z directions. During rotation of the table  114 , the ring  118  of gantry  110  can also rotate simultaneously for certain treatment sites, such as the brain. 
         [0037]    While the table  114  is moving, the aperture shape and the orientation of the MLC  113  can be dynamically varied. In addition, the fluence-output rate (“dose rate”) and gantry rotation speed and consequently speed of rotation of the radiation source  104  can be varied. Control of the table motion, the gantry motion, fluence-output rate, MLC orientation and shape of the MLC is performed by computer  116 . The software used to control the computer  116  can be similar to software used in VMAT, wherein the software for C-ARC is such that clinically acceptable dosimetry is generated while avoiding any collision between the table  114 , gantry  110  and its attachments, and the patient. With the above description of the system  100  in mind, a possible process for operation of the system  100  is described herein with respect to the flow chart of  FIG. 2 . In particular, a process  200  is schematically shown that involves first forming a computed tomography or other three dimensional planning image of an area of the patient that is known to contain an object of interest, such as a tumor, for treatment per process  210 . The planning image can be performed off-site or by using the computed tomography system  102  on-site. The three-dimensional information of the image of the general area of the tumor is then fed to computer  116  or another computer to compute a virtual three-dimensional radiation therapy plan per process  220  for varying table motion, gantry motion, fluence output rate, MLC orientation and shape of the MLC in order to apply a desired therapy dose to the tumor while reducing dosage to healthy tissue. 
         [0038]    After the virtual plan is computed, the patient can now be treated with radiation in accordance with the plan. With that said, it should be kept in mind that the virtual plan assumes that the tumor will be positioned at the same spatial position when it was imaged per process  210 . When the patient is placed on the table  114  per process  230 , the spatial position of the tumor can be fine tuned per process  240  to be the same when it was imaged per process  210  in one of two manners. One manner for line tuning the spatial position is to have the technician reposition the patient until he or she visualizes that a skin marker on the patient is in the same position that it was when the image was taken per process  210 . A second manner of fine tuning is to take a three-dimensional image of the tumor using computed tomography system  102  and adjust the position of the patient so that the tumor shown in the fine tuning image will be repositioned to coincide with the position of the tumor determined per process  210 . Once the patient has been repositioned per process  240 , the virtual plan of process  220  is then applied to the tumor per process  250 . 
         [0039]    Note that besides the fine tuning process mentioned previously, the treatment using the C-ARC plan can be performed in a real-time manner as described in U.S. Pat. Nos. 6,842,502 and 7,471,765, wherein real-time imaging of the tumor is performed during the radiation treatment and the real-time images of the tumor are used by computer  116  to control the table motion, the gantry motion, fluence output rate, MLC orientation and shape of the MLC. 
         [0040]    An example of the above described real-time C-ARC treatment is schematically shown in  FIG. 3 . In particular, a kV cone beam is directed through the patient on table  114  and a three dimensional real time image is generated on a flat panel imager  108 . In addition, an MV portal imager  120  is also simultaneously used to generate a real-time two-dimensional image of the patient based on the therapeutic radiation emitted by source  104  (not shown) that is positioned opposite the imager  120 . Such simultaneous real-time imaging by both kV cone beam projection imaging and MV portal imaging during therapeutic radiation delivery is made possible by taking advantage of the rotation features of VMAT and C-ARC in beam patient orientation. The projection images of MV portal imaging and kV cone beam projection imaging can be processed for 2D and 3D verification images, respectively, to monitor patient/anatomy position motion/variation in real-time during the therapeutic radiation treatment. 
         [0041]    Examples of kV and MV portal images formed by the kV cone beam and MV imagers described above and at various gantry rotational positions are shown in  FIGS. 5A-D , wherein an area of a spine is being treated. Corresponding images of reference digitally reconstructed radiographic with beam&#39;s eye view are shown in  FIGS. 4A-D . (it represents the object within the beam direction and aperture) 
         [0042]    With the above description of the C-ARC treatment plan, a comparison with other known treatment plans illustrates the advantages of the present invention. In the case of treatment of tumors in the breast via accelerated partial breast irradiation(APBI), the gantry  110  remains stationary at tangent angles while the table  114  rotates through one medial and one lateral arc, wherein the medial and lateral arcs are defined with respect to the orientation of the breast of the patient. 
         [0043]    In the case of when the breast in question has been previously treated by a 3D-CRT plan, the beam arrangement of the 3D-CRT plan can be used to guide C-ARC planning, as it is deemed to have provided clinically acceptable dosimetry while avoiding any collision between the table, gantry, and the patient. The table positions from the 3D-CRT plan are taken as the limits of the table arcs. Similarly, the gantry position for each arc is chosen to be the same as that in the 3D-CRT plan. Optimization and dose calculation is done with control points positioned at 10° intervals along the arcs. Such breast treatment maintains the benefits of the standard tangent beam arrangement of APBI treated with 3D-CRT. C-ARC is a natural extension of the innovation of VMAT to the realm of breast radiotherapy, in which the standard tangent beam geometry minimizes dose outside the target. This is shown in  FIGS. 6A and 7A  where radiations beams using C-ARC are directed mostly to the breast and little radiation affects healthy organs, such as the heart and lungs. In contrast, APBI when applied with IMRT and VMAT can lead to beams being directed to health tissue as shown in  FIGS. 6B-C  and  7 B-C. 
         [0044]    In the comparison to follow, it regards patients previously treated with APBI via 3D-CRT and three additional and subsequent plans were generated for each patient: 1) a C-ARC plan, 2) an IMRT plan, and 3) a VMAT plan. The DVH parameters used for evaluation were taken largely from the normal tissue constraints of the NSABP-B39/RTOG 0413 protocol for breast therapy and are listed in Table 1 below: 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Normal tissue dose constraints of the NSABP B-39/RTOG 0413 
               
               
                 protocol and plan comparison parameters, mean values and range, 
               
               
                 for 3D-CRT, IMRT, C-ARC, and VMAT plans 
               
             
          
           
               
                   
                 NSABP B-39/ 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 RTOC 0413 
               
               
                   
                 Normal Tissue Dose 
               
               
                   
                 Constraints (1) 
                 3D-CRT 
                 C-ARC 
                 p 
                 IMRT 
                 p 
                 VMAT 
                 p 
               
               
                   
                   
               
             
          
           
               
                 Normal 
                 &lt;60% 
                 50.5% 
                 42.7% 
                 &lt;0.001 
                 42.8% 
                 &lt;0.001  
                 42.6% 
                 &lt;0.001 
               
               
                 breast V50% 
                   
                 (39.5-61.1)  
                   
                 (35.1-49.2) 
                   
                 (34.6-50.6) 
                   
                 (33.7-52.7) 
               
               
                 Normal 
                 &lt;35% 
                 20.2% 
                 17.0% 
                 &lt;0.001 
                 16.6% 
                 &lt;0.001  
                 15.8% 
                 &lt;0.001 
               
               
                 breast 
                   
                 (11.6-31.3)  
                   
                 (14.4-24.5) 
                   
                 (10.2-25.9) 
                   
                  (8.3-24.5) 
               
               
                 V100% 
               
               
                 Ipsilateral 
                 &lt;15% 
                  6.1% 
                 3.6% 
                 0.004 
                 3.5% 
                 0.003 
                 3.7% 
                 0.002 
               
               
                 lung V30% 
                   
                 (0.3-10.0) 
                   
                 (0.1-8.5) 
                   
                 (0.2-8.2) 
                   
                 (0.0-8.1) 
               
               
                 Ipsilateral 
                 n/a 
                 11.2% 
                 7.8% 
                 0.001 
                 7.7% 
                 0.005 
                 10.4% 
                 0.381 
               
               
                 lung V5Gy 
                   
                 (1.2-17.6) 
                   
                  (0.9-12.9) 
                   
                  (1.0-13.0) 
                   
                  (2.2-17.7) 
               
               
                 Heart V5% 
                 &lt;5% for right-sided 
                  6.8% 
                 5.5% 
                 0.018 
                 5.7% 
                 0.018 
                 7.7% 
                 1 
               
               
                   
                 lesions 
                 (0.0-43.0) 
                   
                  (0.0-39.1) 
                   
                  (0.0-38.6) 
                   
                  (0.0-39.5) 
               
               
                   
                 &lt;40% for left-sided 
               
               
                   
                 lesions 
               
               
                 Contralateral 
                  &lt;3% 
                 374.80 
                 260.97 
                 0.006 
                 198.25 
                 0.002 
                 288.24 
                 0.424 
               
               
                 breast Dmax 
                   
                  (58.10-2451.20) 
                   
                  (56.30-1841.60) 
                   
                   (54.5-1364.00) 
                   
                  (86.30-1529.20) 
               
               
                 Monitor 
                 n/a 
                 827.21 
                 488.31 
                 &lt;0.001 
                 691.33 
                 0.013 
                 546.44 
                 &lt;0.001 
               
               
                 Units 
                   
                 (607.45-1084.30) 
                   
                 (448.40-525.90) 
                   
                 (555.00-928.30) 
                   
                 (484.40-667.00) 
               
             
          
           
               
                 Control 
                 n/a 
                 4  
                 9-14 
                 23-25 
                 18-20 
               
               
                 Points 
               
               
                   
               
             
          
         
       
     
         [0045]    Table 1 above lists the mean values for the normal tissue doses of the C-ARC, IMRT, and VMAT plans, all of which are compared to the original 3D-CRT plan. All three treatment planning modalities significantly decrease the volume of normal ipsilateral breast tissue V50%, reducing this value by 7.8% on average (See  FIG. 8A ). As shown, all three plans significantly decrease the ipsilateral lung V30%, but only the C-ARC and IMRT plans do so for the V5Gy (See  FIG. 8B ). There are no significant reductions in the contralateral lung V5%. Four VMAT plans generate an unavoidably high Dmax in the contralateral breast that exceeds both the 3D-CRT plan and the normal tissue dose constraints outlined in the NSABP B-39/RTOG 0413 protocol (Table 1). None of the IMRT and C-ARC plans produce such violations. The C-ARC, IMRT, and VMAT plans all significantly reduce the number of monitor units compared with 3D-CRT, with the C-ARC plans prescribing the lowest mean number of MU (mean decrease: IMRT 136 MU, p=0.013, VMAT 281 MU, p&lt;0.001, C-ARC 339 MU, p&lt;0.001). 
         [0046]    C-ARC and VMAT plans are also compared. These two planning modalities produce comparable reductions in the volume of ipsilateral breast receiving 50% and 100% of the prescribed dose, as well as the ipsilateral lung receiving 30% of the prescribed dose. However, VMAT plans result in significantly larger ipsilateral lung volumes receiving 5Gy (10.4% vs. 7.8%, p=0.008) and heart volumes receiving 192.5 cGy (7.7% vs. 5.5%, p=0.021).  FIGS. 9A-B  show representative axial dose distributions for C-ARC and VMAT, respectively. As well, C-ARC plans prescribed a significantly lower number of monitor units compared to VMAT plans (p=0.011). A non-significant trend (p=0.05) emerged of the C-ARC plans delivering a lower Dmax to the contralateral breast. 
         [0047]    In addition to reducing the dose to the ipsilateral breast, C-ARC plans decrease dose to the lung and heart. C-ARC and IMRT provided the greatest reductions in ipsilateral lung irradiation as measured by V5Gy due to their lack of en face geometry. C-ARC and IMRT plans also produced significant reductions in low dose irradiation of the heart. 
         [0048]    Due to a lack of wedges, the C-ARC, IMRT, and VMAT plans all reduced the number of monitor units prescribed in comparison to the 3D-CRT plans, with C-ARC plans providing the greatest reduction. C-ARC plans also used the smallest number of control points, thereby minimizing leakage radiation. 
         [0049]    As shown in Table 1, C-ARC plans produce a significant reduction in ipsilateral breast irradiation without increasing dose to the lungs, heart, and contralateral breast. VMAT plans are also able to reduce radiation dose to the ipsilateral breast, but this can come more often at the expense of increased dose elsewhere. 
         [0050]    A natural extension of VMAT, C-ARC will allow for treatment with improved conformality, decreased delivery of monitor units, and anticipated shorter treatment times. The complexity of C-ARC is not significantly greater than that of existing arc therapy from the point of view of the treatment planner and operator. In order for this innovation to take place it will be necessary to link couch rotation control to dose rate and multileaf collimator motion. Minor modification of VMAT planning software will also be required to incorporate couch arcs. 
         [0051]    In the case of APBI C-ARC therapy, the gantry  110  is stationary while the table  114  moves. There are instances where C-ARC therapy can involve simultaneous movement of the table  114  and the gantry  110 . An example of this is when partial brain radiation therapy is employed. Movement of the table  114  and gantry  110  allows for the amount of therapeutic radiation applied to the healthy areas involving the optic chlasm, optic nerve and brain stem. Indeed, when compared with IMRT, C-ARC therapy employs reduced mean and maximum dosages for the optic chlasm, optic nerve and brain stem when compared with IMRT 
         [0052]    From the foregoing description, one skilled in the art can readily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and/or modifications of the invention to adapt it to various usages and conditions.