Abstract:
Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. 
     
       
                 
         
             
             
         
       
     
     See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Description:
FIELD OF THE INVENTION 
     The invention relates to fungicide, pesticide, and acaricide. Specifically to a novel substituted pyrimidine compounds and uses thereof. 
     BACKGROUND OF THE INVENTION 
     Compounds represented by following general formula and specific compound (No. 47 compound in Patent EP0370704 and No. A compound in Patent JP2009161472) were reported in Patent EP0370704 and JP2009161472, some compounds have some fungicidal and insecticidal activities. Known as a developed commercial fungicide, its English general name is diflumetorim, and Chinese name is Fumijunan. Specific compound (No. 5 compound in the literature) was also reported effective to wheat rust and barley powdery mildew in Pesticide Science. 1999 55: 896-902. 
     
       
                 
         
             
             
         
      
     
     The preparation method of specific compound (No. 7 compound in Patent JP11012253) were reported in Patent JP11012253, JP11049759 and EP0665225, and its English general name is flufenerim, and Chinese name is Michongan. 
     
       
                 
         
             
             
         
      
     
     The preparation method of specific pyrimidinamine compounds represented by following general formula CK1, CK2, CK3 and CK4 (No. 83, 87, 101 and 41 compounds in Patent EP0665225) were reported in Patent EP0665225, JP10036355 and U.S. Pat. No. 5,498,612, their fungicidal, insecticidal and acricidal activities were also reported. 
     
       
                 
         
             
             
         
      
     
     Compounds represented by following general formula and specific compound (No. 447 compound) were reported in U.S. Pat. No. 5,925,644, some compounds have some fungicidal, acricidal and nematicidal activities. 
     
       
                 
         
             
             
         
      
     
     Disclosed in Patent EP264217, DE3786390, U.S. Pat. No. 4,895,849, U.S. Pat. No. 4,985,426 and JP63225364 are substituted pyrimidine benzylamine compounds having a structure as represented by following formula and the specific compound CK6 and CK7 (No. 77 and 74 compounds in Patent EP264217) applied as fungicide, insecticide and acricide. 
     
       
                 
         
             
             
         
      
     
     Disclosed in Patent WO9507278 is the compound having a structure as represented by following formula with application as fungicide, acricide and/or insecticide. Thereinto, the specific compound CK8, CK9 and CK10 were listed in No. 209 line of Table 1 without any biological activity reported. 
     
       
                 
         
             
             
         
      
     
     Disclosed in U.S. Pat. No. 5,227,387 are the compound having a structure as represented by following formula and the specific compound CK11 (No. 81 compound in the patent) applied as nematicide. 
     
       
                 
         
             
             
         
      
     
     Compound represented by following formula and the specific compound CK12 (No. 29 compound in the patent) with application as fungicide and insecticide were disclosed in U.S. Pat. No. 5,326,766. 
     
       
                 
         
             
             
         
      
     
     Compound represented by following formula and the specific compound CK13 (No. 98 compound in the patent), CK14 (No. 271 compound in the patent) and CK15 (No. 117 compound in the patent) with application as fungicide and insecticide were disclosed in Patent EP534341. 
     
       
                 
         
             
             
         
      
     
     Compound represented by following general formula and the specific compound CK16 (No. 26 compound in the patent) applied as fungicide, insecticide and acricide were disclosed in Patent WO9728133. 
     
       
                 
         
             
             
         
      
     
     Compound represented by following general formula and the specific compound CK17 (No. 2.50 compound in U.S. Pat. No. 5,468,751) with application as fungicide, insecticide and acricide were disclosed in U.S. Pat. No. 5,468,751 and EP470600. 
     
       
                 
         
             
             
         
      
     
     Compound represented by following general formula with application as inhibitor to treat HIV-1 was disclosed in Literature Bioorganic &amp; Medicinal Chemistry Letters, 2007, 17: 260-265. 
     
       
                 
         
             
             
         
      
     
     The following compound CK18 (No. 46 compound in the patent) and CK19 (No. 49 compound in the patent) were reported with good insectcidal activity at the concentration of 50 ppm and good fungicidal activity at the concentration of 400 and 100 ppm. 
     
       
                 
         
             
             
         
      
     
     The following compound CK20 (CAS No. 203734-18-3) and CK21 (CAS No. 203734-22-9) were retrieved via Scifinder database without both specific literature and biological activity disclosed. 
     
       
                 
         
             
             
         
      
     
     However, substituted pyrimidine compounds represented by general formula PY of the present invention have not been reported in prior literature. 
     SUMMARY OF THE INVENTION 
     The object of the present invention is to provide a novel substituted pyrimidine compounds, which can be used to prepare fungicides, pesticides, and acaricides against harmful fungus, bacteria, insects, and mites in agricultural or other fields. 
     Detailed descriptions of the invention are as follows: 
     The present invention provides a kind of substituted pyrimidine compounds having a structure as represented by general formula PY: 
     
       
                 
         
             
             
         
      
     
     Wherein: 
     R 1  is selected from H, halo, cyano, C 1 -C 12 alkyl, C 3 -C 12 cycloalkyl, haloC 1 -C 12 alkyl, cyanoC 1 -C 12 alkyl, cyanoC 1 -C 12 alkoxy, C 2 -C 12 alkenyl, haloC 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonylC 1 -C 12 alkyl or di(C 1 -C 12 alkyl)aminocarbonylC 1 -C 12 alkyl; 
     R 2  is selected from H, halo, cyano, C 3 -C 12 cycloalkyl, C 1 -C 12 alkyl, C 1 -C 12 alkoxy or haloC 1 -C 12 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, OH, amino, C 1 -C 12 alkyl, C 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, unsubstituted or further substituted arylC 1 -C 6 alkyl or heteroarylC 1 -C 6 alkyl by 1 to 5 following groups: halo, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, OH, NO 2 , cyano, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 3 -C 12 cycloalkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 2 -C 12 alkenyl, haloC 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkynyl, C 3 -C 12 alkenoxy, haloC 3 -C 12 alkenoxy, C 3 -C 12 alkynoxy, haloC 3 -C 12 alkynoxy, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkylcarbonyloxy, C 1 -C 12 alkylcarbonylamino, C 1 -C 12 alkylsulfonyloxy, C 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylamino, C 1 -C 12 alkoxyC 1 -C 12 alkoxy or C 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy; 
     X 1  is selected from N or CR 6 ; X 2  is selected from N or CR 7 ; X 3  is selected from N or CR 8 ; 
     X 4  is selected from N or CR 9 ; X 5  is selected from N or CR 10 ; X 6  is selected from N or CR 11 ; however, X 2 , X 3 , X 4 , X 5 , X 6  are not simultaneously selected from N; 
     R 6 , R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 2 -C 12 alkenoxy, haloC 2 -C 12 alkenoxy, C 2 -C 12 alkynoxy, haloC 2 -C 12 alkynoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, C 1 -C 12 alkylamino, haloC 1 -C 12 alkylamino, di(C 1 -C 12 alkyl)amino, halodi(C 1 -C 12 alkyl)amino, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, di(C 1 -C 12 alkyl)amino(C 1 -C 12 alkyl), CONH 2 , CONHNH 2 , CON(C 1 -C 12 alkyl)NH 2 , CONHNH(C 1 -C 12 alkyl), CONHN(di(C 1 -C 12 alkyl)), CONHNHCO(C 1 -C 12 alkyl), CONHNHCO 2 (C 1 -C 12 alkyl), CONHNH(phenyl), C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, halodi(C 1 -C 12 alkyl)aminocarbonyl, C 1 -C 12 alkylsulfonylamino, C 1 -C 12 alkylsulfonyl(C 1 -C 12 alkyl)amino, haloC 1 -C 12 alkylsulfonylamino, C 1 -C 12 alkoxyamino, C 1 -C 12 alkoxycarbonylamino, C 1 -C 12 alkoxyaminocarbonyl, cyanoC 1 -C 12 alkyl, cyanoC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, haloC 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1- C 12 alkylaminocarbonylC 1 -C 12 alkyl, di(C 1 -C 12 alkyl)aminocarbonylC 1 -C 12 alkyl, C 1- C 12 alkylthiocarbonylC 1 -C 12 alkyl, haloC 1 -C 12 alkylthiocarbonylC 1 -C 12 alkyl, C 1- C 12 alkylcarbonyloxy, haloC 1 -C 12 alkylcarbonyloxy, C 1 -C 12 alkoxycarbonyloxy, haloC 1 -C 12 alkoxycarbonyloxy, C 1 -C 12 alkylaminocarbonyloxy, haloC 1 -C 12 alkylaminocarbonyloxy, C 1 -C 12 alkylsulfonyloxy, haloC 1 -C 12 alkylsulfonyloxy, C 1 -C 12 alkoxyC 1 -C 12 alkoxy, haloC 1 -C 12 alkoxyC 1 -C 2 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy or haloC 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy; 
     W is selected from H, halo, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, C 1 -C 2 alkylthio or C 1 -C 12 alkylsulfonyl; 
     A is selected from O, S or NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 2 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 1 -C 12 alkylthio, C 2 -C 12 alkenylthio, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, di(C 1 -C 12 alkyl)aminosulfonyl, C 1 -C 12 alkylsulfonylaminocarbonyl, C 1 -C 12 alkylcarbonylaminosulfonyl, C 3 -C 12 cycloalkyloxycarbonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylcarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 2 -C 12 alkenoxycarbonyl, C 2 -C 12 alkynoxycarbonyl, C 1 -C 12 alkoxyC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylaminothio, di (C 1 -C 12 alkyl) aminothio, unsubstituted or further substituted (hetero)arylcarbonylC 1 -C 6 alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC 1 -C 6 alkyloxycarbonyl or (hetero)arylC 1 -C 6 alkyl by 1 to 5 following groups: halo, NO 2 , cyano, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; 
     Or the salts or complexes formed from the compounds represented by general formula PY. 
     The technical scheme of the present invention can be further subdivided into three optimization of technical schemes. 
     The first optimization of technical schemes is: the compounds represented by formula PY, wherein, X 1  is selected from CR 6 , X 2  is selected from N or CR 7 , X 3  is selected from N or CR 8 , X 4  is selected from CR 9 , X 5  is selected from CR 10 , X 6  is selected from N or CR 11 , within X 2 , X 3  and X 6 , at least one of which is selected from N, other substituents are defined as above, the compound having a structure as represented by formula I is as fellows. 
     The second optimization of technical schemes is: the compounds represented by formula PY, wherein, X 1  is selected from CR 6 , X 2  is selected from CR 7 , X 3  is selected from CR 8 , X 4  is selected from CR 9 , X 5  is selected from CR 10 , X 6  is selected from CR 11 , other substituents are defined as above, the compound having a structure as represented by formula II is as fellows. 
     The third optimization of technical schemes is: the compounds represented by formula PY, wherein, X 1  is selected from N, X 2  is selected from N or CR 7 , X 3  is selected from N or CR 8 , X 4  is selected from N or CR 9 , X 5  is selected from CR 10 , X 6  is selected from N or CR 11 , within X 2 , X 3 , X 4  and X 6 , at least one of which is selected from N, other substituents are defined as above, the compound having a structure as represented by formula III is as fellows. 
     
       
                 
         
             
             
         
      
     
     Detailed descriptions of three technical schemes of present invention are respectively disclosed. 
     The first optimization of technical schemes is: 
     the compounds having a structure as represented by formula I are as fellows. 
     
       
                 
         
             
             
         
      
     
     Wherein: 
     R 1  is selected from cyano, C 3 -C 12 cycloalkyl, C 1 -C 12 alkyl, halomethyl, cyanoC 1 -C 2 alkyl, cyanoC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonylC 1 -C 12 alkyl or di(C 1 -C 12 alkyl)aminocarbonylC 1 -C 12 alkyl; 
     R 2  is selected from halo, cyano, C 3 -C 12 cycloalkyl, C 1 -C 12 alkyl or C 1 -C 12 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, OH, amino, C 1 -C 12 alkyl or C 1 -C 12 alkoxy; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, OH, C 1 -C 12 alkyl or C 1 -C 12 alkoxy; 
     X 2  is selected from N or CR 7 , X 3  is selected from N or CR 8 , X 6  is selected from N or CR 11 , within X 2 , X 3 , X 6 , at least one substituent is selected from N; 
     R 9  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 2 -C 12 alkenoxy, haloC 2 -C 12 alkenoxy, C 2 -C 12 alkynoxy, haloC 2 -C 12 alkynoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, C 1 -C 12 alkylamino, haloC 1 -C 12 alkylamino, di(C 1 -C 12 alkyl)amino, C 1 -C 12 alkoxycarbonyl, di(C 1 -C 12 alkyl)amino(C 1 -C 12 alkyl), haloC 1 -C 12 alkoxycarbonyl, CONH 2 , CONHNH 2 , CON(C 1 -C 12 alkyl)NH 2 , CONHNH(C 1 -C 12 alkyl), CONHN(di(C 1 -C 12 alkyl)), CONHNHCO(C 1 -C 12 alkyl), CONHNHCO 2 (C 1 -C 12 alkyl), CONHNH(phenyl), C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 1 -C 12 alkylsulfonylamino, C 1 -C 12 alkylsulfonyl(C 1 -C 12 alkyl)amino, haloC 1 -C 12 alkylsulfonylamino, C 1 -C 12 alkoxyamino, C 1 -C 12 alkoxycarbonylamino, C 1 -C 12 alkoxyaminocarbonyl, cyanoC 1 -C 12 alkyl, cyanoC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonylC 1 -C 12 alkyl or di(C 1 -C 12 alkyl)aminocarbonylC 1 -C 12 alkyl; 
     R 6 , R 7 , R 8 , R 10 , R 11  may be the same or different, selected respectively from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 2 -C 12 alkenoxy, haloC 2 -C 12 alkenoxy, C 2 -C 12 alkynoxy, haloC 2 -C 12 alkynoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylamino, haloC 1 -C 12 alkylamino, di(C 1 -C 12 alkyl)amino, C 1 -C 12 alkoxycarbonyl, CONH 2 , C 1 -C 12 alkylaminocarbonyl or di(C 1 -C 12 alkyl)aminocarbonyl; 
     W is selected from H or C 1 -C 12 alkyl; 
     A is selected from O, S or NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 1 -C 12 alkylthio, C 2 -C 12 alkenylthio, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, di(C 1 -C 12 alkyl)aminosulfonyl, C 1 -C 12 alkylsulfonylaminocarbonyl, C 1 -C 12 alkylcarbonylaminosulfonyl, C 3 -C 12 cycloalkyloxycarbonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylcarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 2 -C 12 alkenoxycarbonyl, C 2 -C 12 alkynoxycarbonyl, C 1 -C 12 alkoxyC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylaminothio, di(C 1 -C 12 alkyl)aminothio, unsubstituted or further substituted (hetero)arylcarbonylC 1 -C 6 alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC 1 -C 6 alkyloxycarbonyl or (hetero)arylC 1 -C 6 alkyl by 1 to 5 following groups: halo, NO 2 , cyano, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; 
     Or the salts or complexes formed from the compounds represented by general formula I. 
     The preferred compounds represented by general formula I of this invention are: 
     R 1  is selected from cyano, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyl, halomethyl, cyanoC 1 -C 6 alkyl, cyanoC 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylaminocarbonylC 1 -C 6 alkyl or di(C 1 -C 6 alkyl)aminocarbonylC 1 -C 6 alkyl; 
     R 2  is selected from halo, cyano, C 3 -C 6 cycloalkyl, C 1 -C 6 alkylorC 1 -C 6 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, OH, amino, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, OH, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; 
     X 2  is selected from N or CR 7 , X 3  is selected from N or CR 8 , X 6  is selected from N or CR 11 , within X 2 , X 3 , X 6 , at least one substituent is selected from N; 
     R 7  is selected from H, halo, cyano or C 1 -C 6 alkyl; 
     R 6 , R 8  may be the same or different, selected respectively from H, halo, cyano, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; 
     R 9  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkenoxy, haloC 2 -C 6 alkenoxy, C 2 -C 6 alkynoxy, haloC 2 -C 6 alkynoxy, C 1 -C 6 alkylthio, haloC 1 -C 6 alkylthio, C 1 -C 6 alkoxyC 1 -C 6 alkyl, haloC 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkylthioC 1 -C 6 alkyl, haloC 1 -C 6 alkylthioC 1 -C 6 alkyl, C 1 -C 6 alkylsulfinyl, haloC 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfonyl, haloC 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylaminosulfonyl, C 1 -C 6 alkylamino, haloC 1 -C 6 alkylamino, di(C 1 -C 6 alkyl)amino, C 1 -C 6 alkoxycarbonyl, CONH 2 , C 1 -C 6 alkylaminocarbonyl, di(C 1 -C 6 alkyl)aminocarbonyl, cyanoC 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylaminocarbonylC 1 -C 6 alkyl or di(C 1 -C 6 alkyl)aminocarbonylC 1 -C 6 alkyl; 
     R 10  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkenoxy, haloC 2 -C 6 alkenoxy, C 2 -C 6 alkynoxy, haloC 2 -C 6 alkynoxy, C 1 -C 6 alkylthio, haloC 1 -C 6 alkylthio, C 1 -C 6 alkoxyC 1 -C 6 alkyl, haloC 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkylthioC 1 -C 6 alkyl, haloC 1 -C 6 alkylthioC 1 -C 6 alkyl, C 1 -C 6 alkylsulfinyl, haloC 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfonyl, haloC 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylamino, haloC 1 -C 6 alkylamino, di(C 1 -C 6 alkyl)amino, C 1 -C 6 alkoxycarbonyl, CONH 2 , C 1 -C 6 alkylaminocarbonyl or di(C 1 -C 6 alkyl)aminocarbonyl; 
     R 11  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, CONH 2 , C 1 -C 6 alkylaminocarbonyl or di(C 1 -C 6 alkyl)aminocarbonyl; 
     W is selected from H or C 1 -C 6 alkyl; 
     A is selected from O, S or NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl or C 1 -C 6 alkylsulfonyl; 
     Or the salts formed from the compounds represented by general formula I with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     In the general formula I, the preferred compounds represented by general formula I-A, I-B, I-C, I-D, I-E, I-F, I-G or I-H of this invention are: 
     
       
                 
         
             
             
         
      
       
                 
         
             
             
         
       
     
     Wherein: 
     R 1  is selected from cyano, C 1 -C 4 alkyl or halomethyl; 
     R 2  is selected from halo, cyano, C 3 -C 4 cycloalkyl, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, OH, amino, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; 
     R 5b  is selected from H, halo, OH, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; 
     R 7  is selected from H, halo, cyano or C 1 -C 4 alkyl; 
     R 8  is selected from H, halo, cyano, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; 
     R 9  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkylthio, haloC 1 -C 4 alkylthio, C 1 -C 4 alkoxyC 1 -C 4 alkyl, haloC 1 -C 4 alkoxyC 1 -C 4 alkyl, C 1 -C 4 alkylthioC 1 -C 4 alkyl, haloC 1 -C 4 alkylthioC 1 -C 4 alkyl, C 1 -C 4 alkylsulfinyl, haloC 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, haloC 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylaminosulfonyl, C 1 -C 4 alkylamino, haloC 1 -C 4 alkylamino, di(C 1 -C 4 alkyl)amino, C 1 -C 4 alkoxycarbonyl, CONH 2 , C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl, cyanoC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonylC 1 -C 4 alkyl, C 1 -C 4 alkylaminocarbonylC 1 -C 4 alkyl or di(C 1 -C 4 alkyl)aminocarbonylC 1 -C 4 alkyl; 
     R 10  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 alkenoxy, haloC 2 -C 4 alkenoxy, C 2 -C 4 alkynoxy, haloC 2 -C 4 alkynoxy, C 1 -C 4 alkylthio, haloC 1 -C 4 alkylthio, C 1 -C 4 alkoxyC 1 -C 4 alkyl, haloC 1 -C 4 alkoxyC 1 -C 4 alkyl, C 1 -C 4 alkylthioC 1 -C 4 alkyl, haloC 1 -C 4 alkylthioC 1 -C 4 alkyl, C 1 -C 4 alkylsulfinyl, haloC 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, haloC 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylamino, haloC 1 -C 4 alkylamino, di(C 1 -C 4 alkyl)amino, C 1 -C 4 alkoxycarbonyl, CONH 2 , C 1 -C 4 alkylaminocarbonyl or di(C 1 -C 4 alkyl)aminocarbonyl; 
     R 11  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonyl, CONH 2 , C 1 -C 4 alkylaminocarbonyl or di(C 1 -C 4 alkyl)aminocarbonyl; 
     Or the salts formed from the compounds represented by general formula I-A, I-B, I-C, I-D, I-E, I-F, I-G or I-H with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, maleic acid, sorbic acid, malic acid or citric acid. 
     In the general formula I, further more, the preferred compounds represented by general formula I-A, I-B, I-C, I-D, I-E, I-F, I-G or I-H of this invention are: 
     R 1  is selected from cyano, CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , CH 2 Cl, CHCl 2 , CH 2 F, CHF 2 , CClF 2 , CCl 3  or CF 3 ; 
     R 2  is selected from F, Cl, Br, cyano, CH 3 , C 2 H 5 , OCH 3  or OC 2 H 5 ; 
     R 3 , R 4  may be the same or different, selected respectively from H, Cl, Br, OH, amino, CH 3 , C 2 H 5 , OCH 3  or OC 2 H 5 ; 
     R 5b  is selected from H, Cl, Br, OH, CH 3 , C 2 H 5 , OCH 3  or OC 2 H 5 ; 
     R 7  is selected from H, Cl or cyano; 
     R 8  is selected from H, Cl, Br, cyano, CH 3  or OCH 3 ; 
     R 9  is selected from H, F, Cl, Br, cyano, HO(C═O), amino, NO 2 , CH 3 , C 2 H 5 , CF 3 , CClF 2 , OCH 3 , OC 2 H 5 , OCF 3 , COOCH 3 , COOC 2 H 5 , CONH 2 , CONHCH 3 , CONHC 2 H 5 , CON(CH 3 ) 2 , SO 2 CH 3  or SO 2 NHCH 3 ; 
     R 10  is selected from H, Cl, cyano, CH 3 , C 2 H 5 , OCH 3  or OC 2 H 5 ; 
     R 11  is selected from H, F, Cl, Br, cyano, HO(C═O), amino, NO 2 , CH 3 , C 2 H 5 , CF 3 , CClF 2 , OCH 3 , OC 2 H 5 , OCF 3 , COOCH 3 , COOC 2 H 5 , CONH 2 , CONHCH 3 , CONHC 2 H 5  or CON(CH 3 ) 2 ; 
     Or the salts formed from the compounds represented by general formula I-A, I-B, I-C, I-D, I-E, I-F, I-G or I-H with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, maleic acid or benzoic acid. 
     Even more preferred compounds represented by general formula I of this invention are: 
     In the general formula I-A, 
     R 1  is selected from CH 3 , C 2 H 5 , CH 2 Cl, CHF 2 , CClF 2 , CCl 3  or CF 3 ; 
     R 2  is selected from Cl, Br or cyano; 
     R 3 , R 4 , R 10  is selected from H; 
     R 5b  is selected from H, Cl, Br or OCH 3 ; 
     R 8  is selected from H or Cl; 
     R 9  is selected from H, Cl, cyano, CF 3 , CClF 2 , COOCH 3 , COOC 2 H 5  or CONH 2 ; 
     R 1  is selected from H, Cl, NO 2 , CF 3 , COOCH 3  or CONHCH 3 ; 
     Or, in the general formula I-B, 
     R 1  is selected from CH 3 , C 2 H 5  or CHF 2 ; 
     R 2  is selected from Cl, Br or cyano; 
     R 9  is selected from Cl, Br, cyano or CF 3 ; 
     R 3 , R 4 , R 5b , R 10 , R 11  is selected from H; 
     Or, in the general formula I-C, 
     R 1  is selected from CH 3 , C 2 H 5  or CHF 2 ; 
     R 2  is selected from Cl, Br or cyano; 
     R 3 , R 4 , R 5b , R 9  is selected from H; 
     R 8 , R 10  is selected from CH 3  or OCH 3 ; 
     Or, in the general formula I-E, 
     R 1  is selected from CH 3 , C 2 H 5  or CHF 2 ; 
     R 2  is selected from Cl, Br or cyano; 
     R 3 , R 4 , R 5b , R 8 , R 10  is selected from H; 
     R 9  is selected from H, Cl, cyano, CF 3 , COOCH 3 , COOC 2 H 5  or CONH 2 ; 
     R 1  is selected from H, Cl or CF 3 ; 
     Or the salts formed from the compounds represented by general formula I-A, I-B, I-C or I-E with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, maleic acid or benzoic acid. 
     Most preferred compounds represented by general formula I of this invention are: 
     In the general formula I-A, 
     R 1  is selected from CH 3 , C 2 H 5 , CH 2 Cl, CHF 2  or CF 3 ; 
     R 2  is selected from Cl, Br or cyano; 
     R 3 , R 4 , R 5b , R 10  is selected from H; 
     R 9  is selected from Cl, cyano or CF 3 ; 
     R 8 , R 11  is selected from H or Cl; 
     Or, in the general formula I-B, 
     R 1  is selected from CH 3 , C 2 H 5  or CHF 2 ; 
     R 2 , R 9  is selected from Cl, Br or cyano; 
     R 3 , R 4 , R 5b , R 10 , R 11  is selected from H; 
     Or the salts formed from the compounds represented by general formula I-A or I-B with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, maleic acid or benzoic acid. 
     The second optimization of technical schemes is: 
     The compounds having a structure as represented by formula II are as fellows. 
     
       
                 
         
             
             
         
      
     
     Wherein: 
     R 1  is selected from C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl or halomethyl; 
     R 2  is selected from halo, cyano or C 1 -C 4 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, C 1 -C 12 alkyl, C 1 -C 12 alkoxy or C 3 -C 12 cycloalkyl; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, OH, C 1 -C 12 alkyl or C 1 -C 12 alkoxy; 
     R 6 , R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, halo, OH, amino, cyano, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12  cycloalkyl, C 1 -C 12 alkylamino, haloC 1 -C 12 alkylamino, di(C 1 -C 12 alkyl)amino, halodi(C 1 -C 12 alkyl)amino, C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, halodi(C 1 -C 12 alkyl)aminocarbonyl, CONH 2 , C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 2 -C 12 alkenoxy, haloC 2 -C 12 alkenoxy, C 2 -C 12 alkynoxy, haloC 2 -C 12 alkynoxy, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, haloC 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylthiocarbonylC 1 -C 12 alkyl, haloC 1 -C 12 alkylthiocarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylcarbonyloxy, haloC 1 -C 12 alkylcarbonyloxy, C 1 -C 12 alkoxycarbonyloxy, haloC 1 -C 12 alkoxycarbonyloxy, C 1 -C 12 alkylaminocarbonyloxy, haloC 1 -C 12 alkylaminocarbonyloxy, C 1 -C 12 alkylsulfonyloxy, haloC 1 -C 12 alkylsulfonyloxy, C 1 -C 12 alkoxyC 1 -C 12 alkoxy, haloC 1 -C 12 alkoxyC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy or haloC 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy; 
     W is selected from H or C 1 -C 12 alkyl; 
     A is selected from NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 1 -C 12 alkylthio, C 2 -C 12 alkenylthio, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, di(C 1 -C 12 alkyl)aminosulfonyl, C 1 -C 12 alkylsulfonylaminocarbonyl, C 1 -C 12 alkylcarbonylaminosulfonyl, C 3 -C 12 cycloalkyloxycarbonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylcarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 2 -C 12 alkenoxycarbonyl, C 2 -C 12 alkynoxycarbonyl, C 1 -C 12 alkoxyC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylaminothio, di (C 1 -C 12 alkyl) aminothio, unsubstituted or further substituted (hetero)arylcarbonylC 1 -C 6 alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC 1 -C 6 alkyloxycarbonyl or (hetero)arylC 1 -C 6 alkyl by 1 to 5 following groups: halo, NO 2 , cyano, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; 
     Or the salts or complexes formed from the compounds of general formula II. 
     The preferred compounds represented by general formula II of this invention are: 
     R 1  is selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or halomethyl; 
     R 2  is selected from halo, cyano or C 1 -C 4 alkoxy; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or C 3 -C 6 cycloalkyl; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c , R 6  may be the same or different, selected respectively from H, halo, OH, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; 
     R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, halo, OH, amino, cyano, NO 2 , C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, C 1 -C 6 alkylamino, haloC 1 -C 6 alkylamino, di(C 1 -C 6 alkyl)amino, halodi(C 1 -C 6 alkyl)amino, C 1 -C 6 alkylaminocarbonyl, di(C 1 -C 6 alkyl)aminocarbonyl, halodi(C 1 -C 6 alkyl)aminocarbonyl, CONH 2 , C 1 -C 6 alkylthio, haloC 1 -C 6 alkylthio, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkenoxy, haloC 2 -C 6 alkenoxy, C 2 -C 6 alkynoxy, haloC 2 -C 6 alkynoxy, C 1 -C 6 alkylsulfonyl, haloC 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylcarbonyl, haloC 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl, haloC 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, haloC 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkylthioC 1 -C 6 alkyl, haloC 1 -C 6 alkylthioC 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, haloC 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylthiocarbonylC 1 -C 6 alkyl, haloC 1 -C 6 alkylthiocarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyloxy, haloC 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkoxycarbonyloxy, haloC 1 -C 6 alkoxycarbonyloxy, C 1 -C 6 alkylaminocarbonyloxy, haloC 1 -C 6 alkylaminocarbonyloxy, C 1 -C 6 alkylsulfonyloxy, haloC 1 -C 6 alkylsulfonyloxy, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, haloC 1 -C 6 alkoxyC 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkoxy or haloC 1 -C 6 alkoxycarbonylC 1 -C 6 alkoxy; 
     W is selected from H or C 1 -C 3 alkyl; 
     A is selected from NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 6 alkyl, C 1 -C 6 alkylsulfonyl or C 1 -C 6 alkylcarbonyl; 
     Or the salts formed from the compounds represented by general formula II with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     Further more, the preferred compounds represented by general formula II of this invention are: 
     R 1  is selected from C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or halomethyl; 
     R 2  is selected from F, Cl, Br or cyano; 
     R 3 , R 4  may be the same or different, selected respectively from H, halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or C 3 -C 6 cycloalkyl; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c , R 6  may be the same or different, selected respectively from H, halo, OH, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; 
     R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, halo, OH, amino, cyano, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylamino, haloC 1 -C 4 alkylamino, di(C 1 -C 4 alkyl)amino, halodi(C 1 -C 4 alkyl)amino, C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl, halodi(C 1 -C 4 alkyl)aminocarbonyl, CONH 2 , C 1 -C 4 alkylthio, haloC 1 -C 4 alkylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 alkenoxy, haloC 2 -C 4 alkenoxy, C 2 -C 4 alkynoxy, haloC 2 -C 4 alkynoxy, C 1 -C 4 alkylsulfonyl, haloC 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylcarbonyl, haloC 1 -C 4 alkylcarbonyl, C 1 -C 4 alkoxycarbonyl, haloC 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkoxyC 1 -C 4 alkyl, haloC 1 -C 4 alkoxyC 1 -C 4 alkyl, C 1 -C 4 alkylthioC 1 -C 4 alkyl, haloC 1 -C 4 alkylthioC 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonylC 1 -C 4 alkyl, haloC 1 -C 4 alkoxycarbonylC 1 -C 4 alkyl, C 1 -C 4 alkylthiocarbonylC 1 -C 4 alkyl, haloC 1 -C 4 alkylthiocarbonylC 1 -C 4 alkyl, C 1 -C 4 alkylcarbonyloxy, haloC 1 -C 4 alkylcarbonyloxy, C 1 -C 4 alkoxycarbonyloxy, haloC 1 -C 4 alkoxycarbonyloxy, C 1 -C 4 alkylaminocarbonyloxy, haloC 1 -C 4 alkylaminocarbonyloxy, C 1 -C 4 alkylsulfonyloxy, haloC 1 -C 4 alkylsulfonyloxy, C 1 -C 4 alkoxyC 1 -C 4 alkoxy, haloC 1 -C 4 alkoxyC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonylC 1 -C 4 alkoxy or haloC 1 -C 4 alkoxycarbonylC 1 -C 4 alkoxy; 
     W is selected from H or CH 3 ; 
     A is selected from NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 4 alkyl, C 1 -C 4 alkylsulfonyl or C 1 -C 4 alkylcarbonyl; 
     Or the salts formed from the compounds represented by general formula II with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, maleic acid, sorbic acid, malic acid or citric acid. 
     Even more preferred compounds represented by formula II of this invention are: 
     R 1  is selected from CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , cyclopropyl, cyclobutyl, CF 3 , CCl 3 , CH 2 F, CH 2 Cl, CH 2 Br, CClF 2 , CCl 2 F, CHF 2  or CHCl 2 ; 
     R 2  is selected from F, Cl, Br or cyano; 
     R 3 , R 4  may be the same or different, selected respectively from H, F, Cl, Br, I, CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , OCH 3 , OC 2 H 5 , OC 3 H 7 -n, OC 3 H 7 -i, OC 4 H 9 -n, OC 4 H 9 -s, OC 4 H 9 -i or OC 4 H 9 -t; 
     R 5a , R 5b , R 5c , R 6  may be the same or different, selected respectively from H, F, Cl, Br, I, OH, CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , OCH 3 , OC 2 H 5 , OC 3 H 7 -n, OC 3 H 7 -i, OC 4 H 9 -n, OC 4 H 9 -s, OC 4 H 9 -i or OC 4 H 9 -t; 
     R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, F, Cl, Br, I, cyano, amino, NO 2 , CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , CF 3 , CCl 3 , CClF 2 , CCl 2 F, CHCl 2 , CH 2 F, CHF 2 , OCH 3 , OC 2 H 5 , OC 3 H 7 -n, OC 3 H 7 -i, OC 4 H 9 -n, OC 4 H 9 -s, OC 4 H 9 -i, OC 4 H 9 -t, OCF 3 , OCH 2 CF 3 , COOCH 3 , COOC 2 H 5 , CONH 2 , CONHCH 3 , CONHC 2 H 5 , CONH(CH 3 ) 2 , methylsulfonyl or trifluoromethylsulfonyl; 
     W is selected from H or CH 3 ; 
     A is selected from NR 12 ; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H; 
     Or the salts formed from the compounds represented by general formula II with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, maleic acid or benzoic acid. 
     Even further more preferred compounds represented by formula II of this invention are: 
     R 1  is selected from CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , cyclopropyl, cyclobutyl, CH 2 Cl, CHCl 2 , CH 2 F, CHF 2 , CClF 2 , CCl 3  or CF 3 ; 
     R 2  is selected from F, Cl, Br or cyano; 
     R 3 , R 4  may be the same or different, selected respectively from H, F, Cl, Br, I, CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , OCH 3 , OC 2 H 5 , OC 3 H 7 -n or OC 3 H 7 -i; 
     R 5a , R 5b , R 5c , R 6  may be the same or different, selected respectively from H, F, Cl, Br or OCH 3 ; 
     R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, F, Cl, Br, I, cyano, NO 2 , CH 3 , C 2 H 5 , n-C 3 H 7 , i-C 3 H 7 , n-C 4 H 9 , s-C 4 H 9 , i-C 4 H 9 , t-C 4 H 9 , OCH 3 , OCF 3 , CF 3 , CCl 3 , CClF 2 , CCl 2 F, CHCl 2 , CH 2 F, CHF 2 , methylsulfonyl or trifluoromethylsulfonyl; 
     W is selected from H or CH 3 ; 
     A is selected from NH; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     Or the salts formed from the compounds of general formula II with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, maleic acid or benzoic acid. 
     Most preferred compounds represented by formula II of this invention are: 
     R 1  is selected from CH 3 , C 2 H 5 , CHF 2  or CF 3 ; 
     R 2  is selected from Cl or cyano; 
     R 3 , R 4  is selected from H; 
     R 5a , R 5b , R 5c , R 6  may be the same or different, selected respectively from H, F, Cl, Br or OCH 3 ; 
     W is selected from H or CH 3 ; 
     R 7 , R 8 , R 9 , R 10 , R 11  may be the same or different, selected respectively from H, F, Cl, cyano, NO 2 , CH 3 , OCH 3 , OCF 3 , CF 3  or methylsulfonyl; 
     A is selected from NH; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     Or the salts formed from the compounds represented by general formula II with hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid or trifluoroacetic acid. 
     The third optimization of technical schemes is: 
     the compounds having a structure as represented by formula III are as fellows. 
     
       
                 
         
             
             
         
      
     
     R 1  is selected from halo, C 1 -C 12 alkyl, C 3 -C 12 cycloalkyl, haloC 1 -C 12 alkyl, C 2 -C 12 alkenyl, haloC 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl or haloC 1 -C 12 alkoxyC 1 -C 12 alkyl; 
     R 2  is selected from halo, cyano, C 1 -C 12 alkyl, C 1 -C 12 alkoxy or haloC 1 -C 12 alkoxy; 
     W is selected from H, halo, C 1 -C 12 alkyl, C 1 -C 12 alkoxy, C 1 -C 12 alkylthio or C 1 -C 12 alkylsulfonyl; 
     R 3 , R 4  may be the same or different, selected respectively from H, C 1 -C 12 alkyl, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, unsubstituted or further substituted arylC 1 -C 6 alkyl or heteroarylC 1 -C 6 alkyl by 1 to 5 following groups: halo, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, NO 2 , cyano, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 3 -C 12 cycloalkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 2 -C 12 alkenyl, haloC 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkynyl, C 3 -C 12 alkenoxy, haloC 3 -C 12 alkenoxy, C 3 -C 12 alkynoxy, haloC 3 -C 12 alkynoxy, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkylcarbonyloxy, C 1 -C 12 alkylcarbonylamino, C 1 -C 12 alkylsulfonyloxy, C 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylamino, C 1 -C 12 alkoxyC 1 -C 12 alkoxy or C 1 -C 12 alkoxycarbonylC 1 -C 12 alkoxy; 
     X 2  is selected from N or CR 7 ; 
     X 3  is selected from N or CR 8 ; 
     X 4  is selected from N or CR 9 ; 
     X 6  is selected from N or CR 11 ; however, X 2 , X 3 , X 4 , X 6  are not simultaneously selected from N; 
     R 7 , R 8 , R 9 , R 1  may be the same or different, selected respectively from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonyl, CONH 2 , C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 1 -C 12 alkylsulfonyl or haloC 1 -C 12 alkylsulfonyl; 
     R 10  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 2 -C 12 alkenoxy, haloC 2 -C 12 alkenoxy, C 2 -C 12 alkynoxy, haloC 2 -C 12 alkynoxy, C 1 -C 12 alkylthio, haloC 1 -C 12 alkylthio, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, C 1 -C 12 alkylamino, haloC 1 -C 12 alkylamino, di(C 1 -C 12 alkyl)amino, C 1 -C 12 alkoxycarbonyl, CONH 2 , C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, cyanoC 1 -C 12 alkoxy, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonylC 1 -C 12 alkyl or di(C 1 -C 12 alkyl)aminocarbonylC 1 -C 12 alkyl; 
     A is selected from O, S or NR 12 ; 
     B is selected from is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 12 alkyl, haloC 1 -C 12 alkyl, C 1 -C 12 alkoxy, haloC 1 -C 12 alkoxy, C 3 -C 12 cycloalkyl, C 1 -C 12 alkylthio, C 2 -C 12 alkenylthio, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, haloC 2 -C 12 alkenyl, haloC 2 -C 12 alkynyl, C 1 -C 12 alkoxyC 1 -C 12 alkyl, haloC 1 -C 12 alkoxyC 1 -C 12 alkyl, C 1 -C 12 alkylthioC 1 -C 12 alkyl, haloC 1 -C 12 alkylthioC 1 -C 12 alkyl, C 1 -C 12 alkylsulfinyl, haloC 1 -C 12 alkylsulfinyl, C 1 -C 12 alkylsulfonyl, haloC 1 -C 12 alkylsulfonyl, C 1 -C 12 alkylaminosulfonyl, di(C 1 -C 12 alkyl)aminosulfonyl, C 1 -C 12 alkylsulfonylaminocarbonyl, C 1 -C 12 alkylcarbonylaminosulfonyl, C 3 -C 12 cycloalkyloxycarbonyl, C 1 -C 12 alkylcarbonyl, haloC 1 -C 12 alkylcarbonyl, C 1 -C 12 alkoxycarbonyl, haloC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylcarbonylC 1 -C 12 alkyl, C 1 -C 12 alkoxycarbonylC 1 -C 12 alkyl, C 1 -C 12 alkylaminocarbonyl, di(C 1 -C 12 alkyl)aminocarbonyl, C 2 -C 12 alkenoxycarbonyl, C 2 -C 12 alkynoxycarbonyl, C 1 -C 12 alkoxyC 1 -C 12 alkoxycarbonyl, C 1 -C 12 alkylaminothio, di(C 1 -C 12 alkyl)aminothio, unsubstituted or further substituted (hetero)arylcarbonylC 1 -C 6 alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC 1 -C 6 alkyloxycarbonyl or (hetero)arylC 1 -C 6 alkyl by 1 to 5 following groups: halo, NO 2 , cyano, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkoxy or haloC 1 -C 6 alkoxy; 
     Or the salts or complexes formed from the compounds represented by general formula III. 
     The preferred compounds represented by general formula III of this invention are: 
     R 1  is selected from halo, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, haloC 1 -C 8 alkyl, C 2 -C 8 alkenyl, haloC 2 -C 8 alkenyl, C 2 -C 8 alkynyl, haloC 2 -C 8 alkynyl, C 1 -C 8 alkoxyC 1 -C 8 alkyl or haloC 1 -C 8 alkoxyC 1 -C 8 alkyl; 
     R 2  is selected from halo, cyano, C 1 -C 8 alkyl, C 1 -C 8 alkoxy or haloC 1 -C 8 alkoxy; 
     W is selected from H, halo, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, C 1 -C 8 alkylthio or C 1 -C 8 alkylsulfonyl; 
     R 3 , R 4  may be the same or different, selected respectively from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, haloC 2 -C 8 alkenyl, haloC 2 -C 8 alkynyl, C 1 -C 8 alkoxyC 1 -C 8 alkyl, unsubstituted or further substituted arylC 1 -C 4 alkyl or heteroarylC 1 -C 4 alkyl by 1 to 3 following groups: halo, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy or haloC 1 -C 4 alkoxy; or R 3 , R 4  and conjoint carbon can also form a C 3 -C 8  cycle; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, NO 2 , cyano, C 1 -C 8 alkyl, haloC 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 8 alkoxy, haloC 1 -C 8 alkoxy, C 1 -C 8 alkylthio, haloC 1 -C 8 alkylthio, C 2 -C 8 alkenyl, haloC 2 -C 8 alkenyl, C 2 -C 8 alkynyl, haloC 2 -C 8 alkynyl, C 3 -C 8 alkenoxy, haloC 3 -C 8 alkenoxy, C 3 -C 8 alkynoxy, haloC 3 -C 8 alkynoxy, C 1 -C 8 alkylsulfinyl, haloC 1 -C 8 alkylsulfinyl, C 1 -C 8 alkylsulfonyl, haloC 1 -C 8 alkylsulfonyl, C 1 -C 8 alkylcarbonyl, haloC 1 -C 8 alkylcarbonyl, C 1 -C 8 alkylcarbonyloxy, C 1 -C 8 alkylcarbonylamino, C 1 -C 8 alkylsulfonyloxy, C 1 -C 8 alkoxycarbonyl, C 1 -C 8 alkoxycarbonylC 1 -C 8 alkyl, C 1 -C 8 alkoxycarbonylamino, C 1 -C 8 alkoxyC 1 -C 8 alkoxy or C 1 -C 8 alkoxycarbonylC 1 -C 8 alkoxy; 
     X 2  is selected from N or CR 7 ; 
     X 3  is selected from N or CR 8 ; 
     X 4  is selected from N or CR 9 ; 
     X 6  is selected from N or CR 11 ; however, X 2 , X 3 , X 4 , X 6  are not simultaneously selected from N; 
     R 7 , R 8 , R 9 , R 11  may be the same or different, selected respectively from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 8 alkyl, haloC 1 -C 8 alkyl, C 1 -C 8 alkoxy, haloC 1 -C 8 alkoxy, C 1 -C 8 alkoxycarbonyl, CONH 2 , C 1 -C 8 alkylaminocarbonyl, di(C 1 -C 8 alkyl)aminocarbonyl, C 1 -C 8 alkylsulfonyl or haloC 1 -C 8 alkylsulfonyl; 
     R 10  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 8 alkyl, haloC 1 -C 8 alkyl, C 1 -C 8 alkoxy, haloC 1 -C 8 alkoxy, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 2 -C 8 alkenoxy, haloC 2 -C 8 alkenoxy, C 2 -C 8 alkynoxy, haloC 2 -C 8 alkynoxy, C 1 -C 8 alkylthio, haloC 1 -C 8 alkylthio, C 1 -C 8 alkoxyC 1 -C 8 alkyl, haloC 1 -C 8 alkoxyC 1 -C 8 alkyl, C 1 -C 8 alkylthioC 1 -C 8 alkyl, haloC 1 -C 8 alkylthioC 1 -C 8 alkyl, C 1 -C 8 alkylsulfinyl, haloC 1 -C 8 alkylsulfinyl, C 1 -C 8 alkylsulfonyl, haloC 1 -C 8 alkylsulfonyl, C 1 -C 8 alkylaminosulfonyl, C 1 -C 8 alkylamino, haloC 1 -C 8 alkylamino, di(C 1 -C 8 alkyl)amino, C 1 -C 8 alkoxycarbonyl, CONH 2 , C 1 -C 8 alkylaminocarbonyl, di(C 1 -C 8 alkyl)aminocarbonyl, cyanoC 1 -C 8 alkoxy, C 1 -C 8 alkoxycarbonylC 1 -C 8 alkyl, C 1 -C 8 alkylaminocarbonylC 1 -C 8 alkyl or di(C 1 -C 8 alkyl)aminocarbonylC 1 -C 8 alkyl; 
     A is selected from O, S or NR 12 ; 
     B is selected from is selected from —CH 2 — or —CH 2 CH 2 —; 
     R 12  is selected from H, OH, H(C)═O, C 1 -C 8 alkyl, haloC 1 -C 8 alkyl, C 1 -C 8 alkoxy, haloC 1 -C 8 alkoxy, C 3 -C 8 cycloalkyl, C 1 -C 8 alkylthio, C 2 -C 8 alkenylthio, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, haloC 2 -C 8 alkenyl, haloC 2 -C 8 alkynyl, C 1 -C 8 alkoxyC 1 -C 8 alkyl, haloC 1 -C 8 alkoxyC 1 -C 8 alkyl, C 1 -C 8 alkylthioC 1 -C 8 alkyl, haloC 1 -C 8 alkylthioC 1 -C 8 alkyl, C 1 -C 8 alkylsulfinyl, haloC 1 -C 8 alkylsulfinyl, C 1 -C 8 alkylsulfonyl, haloC 1 -C 8 alkylsulfonyl, C 1 -C 8 alkylaminosulfonyl, di(C 1 -C 8 alkyl)aminosulfonyl, C 1 -C 8 alkylsulfonylaminocarbonyl, C 1 -C 8 alkylcarbonylaminosulfonyl, C 3 -C 8 cycloalkyloxycarbonyl, C 1 -C 8 alkylcarbonyl, haloC 1 -C 8 alkylcarbonyl, C 1 -C 8 alkoxycarbonyl, haloC 1 -C 8 alkoxycarbonyl, C 1 -C 8 alkylcarbonylC 1 -C 8 alkyl, C 1 -C 8 alkoxycarbonylC 1 -C 8 alkyl, C 1 -C 8 alkylaminocarbonyl, di(C 1 -C 8 alkyl)aminocarbonyl, C 2 -C 8 alkenoxycarbonyl, C 2 -C 8 alkynoxycarbonyl, C 1 -C 8 alkoxyC 1 -C 8 alkoxycarbonyl, C 1 -C 8 alkylaminothio, di (C 1 -C 8 alkyl) aminothio, unsubstituted or further substituted (hetero)arylcarbonylC 1 -C 6 alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC 1 -C 6 alkyloxycarbonyl or (hetero)arylC 1 -C 6 alkyl by 1 to 3 following groups: halo, NO 2 , cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy or haloC 1 -C 4 alkoxy; 
     Or the salts formed from the compounds represented by general formula III. 
     Further more, the preferred compounds represented by general formula III of this invention are: 
     R 1  is selected from halo, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, haloC 1 -C 4 alkyl, C 2 -C 4 alkenyl, haloC 2 -C 4 alkenyl, C 2 -C 4 alkynyl, haloC 2 -C 4 alkynyl, C 1 -C 4 alkoxyC 1 -C 4 alkyl or haloC 1 -C 4 alkoxyC 1 -C 4 alkyl; 
     R 2  is selected from halo or cyano; 
     W is selected from H or CH 3 ; 
     R 3 , R 4  is selected from H, CH 3  or C 2 H 5 ; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, halo, NO 2 , cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkylthio, haloC 1 -C 4 alkylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylcarbonyl or C 1 -C 4 alkoxyC 1 -C 4 alkoxy; 
     X 2  is selected from N or CR 7 ; 
     X 3  is selected from N or CR 8 ; 
     X 4  is selected from N or CR 9 ; 
     X 6  is selected from N or CR 11 ; however, X 2 , X 3 , X 4 , X 6  are not simultaneously selected from N; 
     R 7 , R 8 , R 9 , R 11  may be the same or different, selected respectively from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonyl, CONH 2 , C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl or C 1 -C 4 alkylsulfonyl or haloC 1 -C 4 alkylsulfonyl; 
     R 10  is selected from H, halo, OH, cyano, HO(C═O), amino, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 alkenoxy, haloC 2 -C 4 alkenoxy, C 2 -C 4 alkynoxy, haloC 2 -C 4 alkynoxy, C 1 -C 4 alkylthio, haloC 1 -C 4 alkylthio, C 1 -C 4 alkoxyC 1 -C 4 alkyl, haloC 1 -C 4 alkoxyC 1 -C 4 alkyl, C 1 -C 4 alkylthioC 1 -C 4 alkyl, haloC 1 -C 4 alkylthioC 1 -C 4 alkyl, C 1 -C 4 alkylsulfinyl, haloC 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, haloC 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylaminosulfonyl, C 1 -C 4 alkylamino, haloC 1 -C 4 alkylamino, di(C 1 -C 4 alkyl)amino, C 1 -C 4 alkoxycarbonyl, CONH 2 , C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl, cyanoC 1 -C 12 alkoxy, C 1 -C 4 alkoxycarbonylC 1 -C 4 alkyl, C 1 -C 4 alkylaminocarbonylC 1 -C 4 alkyl or di(C 1 -C 4 alkyl)aminocarbonylC 1 -C 4 alkyl; 
     A is selected from O, S or NH; 
     B is selected from —CH 2 — or —CH 2 CH 2 —; 
     Or the salts formed from the compounds represented by general formula III with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     In the general formula III, even more preferred compounds represented by general formula III-A, III-B, III-C, III-D, III-E, III-F, III-G, III-H, III-I or III-J of this invention are: 
     
       
                 
         
             
             
         
      
       
                 
         
             
             
         
       
     
     Wherein: 
     R 1  is selected from F, Cl, Br, I, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, haloC 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxyC 1 -C 4 alkyl or haloC 1 -C 4 alkoxyC 1 -C 4 alkyl; 
     R 2  is selected from halo or cyano; 
     W is selected from H or CH 3 ; 
     R 3 , R 4  is selected from H, CH 3  or C 2 H 5 ; 
     R 5a , R 5b , R 5c  may be the same or different, selected respectively from H, F, Cl, Br, I, NO 2 , cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy or C 1 -C 4 alkylcarbonyl; 
     R 7 , R 8 , R 9 , R 11  may be the same or different, selected respectively from H, F, Cl, Br, I, cyano, HO(C═O), NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl, C 1 -C 4 alkylsulfonyl or haloC 1 -C 4 alkylsulfonyl; 
     R 10  is selected from H, F, Cl, Br, I, cyano, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkylsulfonyl or haloC 1 -C 4 alkylsulfonyl; 
     A is selected from O, S or NH; 
     Or the salts formed from the compounds represented by general formula III-A, III-B, III-C, III-D, III-E, III-F, III-G, III-H, III-I or III-J with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     Even further more preferred compounds represented by formula III of this invention are: 
     R 1  is selected from Cl, CH 3 , C 2 H 5 , CHCl 2 , CCl 3 , CH 2 F, CClF 2 , CHF 2  or CF 3 ; 
     R 2  is selected from halo or cyano; 
     W is selected from H or CH 3 ; 
     R 3 , R 4  is selected from H; 
     R 5a , R 5c  is selected from H; 
     R 5b  is selected from H, F, Cl, Br or OCH 3 ; 
     R 7 , R 8 , R 9 , R 11  may be the same or different, selected respectively from H, F, Cl, Br, cyano, NO 2 , C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylaminocarbonyl, di(C 1 -C 4 alkyl)aminocarbonyl, C 1 -C 4 alkylsulfonyl or haloC 1 -C 4 alkylsulfonyl; 
     R 10  is selected from H, F, Cl, Br, I, cyano, NO 2 , methylsulfonyl, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 1 -C 4 alkoxy or haloC 1 -C 4 alkoxy; 
     A is selected from NH; 
     Or the salts formed from the compounds represented by general formula III-A with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     Most preferred compounds represented by formula III of this invention are: 
     In the general formula III-A, 
     R 1  is selected from Cl, CH 3 , C 2 H 5 , CHF 2  or CF 3 ; 
     R 2  is selected from Cl or cyano; 
     W is selected from H or CH 3 ; 
     R 3 , R 4  is selected from H; 
     R 5a , R 5c  is selected from H; 
     R 5b  is selected from H, Cl or OCH 3 ; 
     R 7 , R 8 , R 9 , R may be the same or different, selected respectively from H, F, Cl, CH 3 , cyano, NO 2 , CF 3 , CClF 2 , CCl 3 , OCH 3 , OCF 3 , OCH 2 CF 3 , methylsulfonyl or trifluorosulfonyl; 
     R 10  is selected from H, F, Cl, CH 3 , cyano, NO 2 , methylsulfonyl, CF 3 , CClF 2 , OCH 3 , OCF 3  or OCH 2 CF 3 ; 
     A is selected from NH; 
     Or the salts formed from the compounds represented by general formula III-A with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methylsulfonic acid, p-toluenesulfonic acid, benzoic acid, alizaric acid, maleic acid, sorbic acid, malic acid or citric acid. 
     The terms of substitutes used above to definite the compounds represented by general formula PY are as follows: 
     The “halogen” or “halo” is fluorine, chlorine, bromine or iodine. 
     The “alkyl” stands for straight or branched chain alkyl, such as methyl, ethyl, propyl, isopropyl or tert-butyl. 
     The “cycloalkyl” is substituted or unsubstituted cyclic alkyl, such as cyclopropyl, cyclopentyl or cyclohexyl. The substitute(s) is(are) methyl, halogen, etc. 
     The “haloalkyl” stands for straight or branched chain alkyl, in which hydrogen atoms can be all or partly substituted with halogen, such as chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, etc. 
     The “alkoxy” refers to straight or branched chain alkyl, which is linked to the structure by oxygen atom. The “haloalkoxy” refers to straight or branched chain alkoxy, in which hydrogen atoms may be all or partly substituted with halogen, such as chloromethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, trifluoroethoxy, etc. The “alkylthio” refers to straight or branched chain alkyl, which is linked to the structure by sulfur atom. The “haloalkylthio” refers to straight or branched chain alkylthio, in which hydrogen atoms may be all or partly substituted with halogen, such as chloromethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, etc.
 
The “cyanoalkyl” refers to straight or branched chain alkyl, in which hydrogen atoms may be all or partly substituted with cyano, such as —CH 2 CN, —CH 2 CH 2 CN, —CH 2 C(CH 3 ) 2  CN, —CH 2 CH(CN) 2 , etc. The “cyanoalkoxy” refers to alkoxy, in which hydrogen atoms may be all or partly substituted with cyano, such as —OCH 2 CN. The “haloalkylamino” refers to straight or branched chain alkylamino, in which hydrogen atoms may be all or partly substituted with halogen. The “dialkylamino” such as —N(CH 3 ) 2 , —N(CH 3 CH 2 ) 2 . The “dihaloalkylamino” such as —N(CF 3 ) 2 , —N(CH 2 CCl 3 ) 2 . The “dialkylaminoalkyl” such as —CH 2 N(CH 3 ) 2 .
 
The “alkenyl” refers to straight or branched chain alkenyl, such as ethenyl, 1-propenyl, 2-propenyl and different isomer of butenyl, pentenyl and hexenyl. Alkenyl also includes polyene, such as propa-1,2-dienyl and hexa-2,4-dienyl. The “haloalkenyl” stands for straight or branched chain alkenyl, in which hydrogen atoms can be all or partly substituted with halogen. The “alkynyl” refers to straight or branched chain alkynyl, such as ethynyl, 1-propynyl, 2-propynyl and different isomer of butynyl, pentynyl and hexynyl. Alkynyl also includes groups including more than one triple bonds, such as hexa-2,5-diynyl. The “haloalkynyl” stands for straight or branched chain alkynyl, in which hydrogen atoms can be all or partly substituted with halogen.
 
The alkenoxyl refers to straight or branched chain alkynes is linked to the structure by oxygen, The haloalkenoxyl stands for a straight-chain or branched alkenoxyl, in which hydrogen atoms may be all or partly substituted with halogen. The alkynoxyl refers to straight or branched chain alkynes is linked to the structure by oxygen. The haloalkynoxyl stands for a straight-chain or branched alkynoxyl, in which hydrogen atoms may be all or partly substituted with halogen.
 
The “alkylsulfinyl” means a straight-chain or branched alkyl is linked to the structure by (—SO—), such as methylsulfinyl.
 
The “haloalkylsulfinyl” stands for a straight-chain or branched alkylsulfinyl, in which hydrogen atoms may be all or partly substituted with halogen.
 
The “alkylsulfonyl” means a straight-chain or branched alkyl is linked to the structure by (—SO 2 —), such as methylsulfonyl.
 
The “haloalkylsulfonyl” stands for a straight-chain or branched alkylsulfonyl, in which hydrogen atoms may be all or partly substituted with halogen.
 
The “alkylcarbonyl” means alkyl is linked to the structure by carbonyl, such as —COCH 3 , —COCH 2 CH 3 . The “haloalkylcarbonyl” stands for a straight-chain or branched alkylcarbonyl, in which hydrogen atoms may be all or partly substituted with halogen, such as —COCF 3 . The “alkoxyalkyl” means alkyl-O-alkyl-, such as —CH 2 OCH 3 . The “haloalkoxyalkyl” refers to alkoxyalkyl, in which hydrogen atom may be all or partyl substituted with halogen, such as —CH 2 OCH 2 CH 2 Cl. The “alkylthioalkyl” means alkyl-S-alkyl-, such as —CH 2 SCH 3 . The “haloalkylthioalkyl” refers to alkylthioalkyl, in which hydrogen atom may be all or partyl substituted with halogen, such as —CH 2 SCH 2 CH 2 Cl, —CH 2 SCH 2 CF 3 .
 
The “alkoxycarbonyl” means alkoxy is linked to the structure by carbonyl, such as —COOCH 3 , —COOCH 2 CH 3 . The “haloalkoxycarbonyl” refers to straight or branched chain alkoxycarbonyl, in which hydrogen atoms can be all or partly substituted with halogen. The “alkylaminocarbonyl” means alkyl-NH—CO—, such as —CONHCH 3 , —CONHCH 2 CH 3 . The “dialkylaminocarbonyl” such as —CON(CH 3 ) 2 , —CON(CH 2 CH 3 ) 2 .
 
The “halodialkylaminocarbonyl” such as —CON(CF 3 ) 2 , —CON(CH 2 CCl 3 ) 2 .
 
The “alkoxycarbonylalkyl” such as —CH 2 COOCH 3 , —CH 2 COOCH 2 CH 3 . The “haloalkoxycarbonylalkyl” such as —CH 2 COOCF 3 , —CH 2 COOCH 2 CF 3 .
 
The “alkoxycarbonylamino” such as —NHCOOCH 3 , —NHCOOCH 2 CH 3 . The “alkoxyaminocarbonyl” such as —CONHOCH 3 , —CONHOCH 2 CH 3 . The “alkylaminocarbonylalkyl” such as —CH 2 CONHCH 3 , —CH 2 CONHCH 2 CH 3 . “dialkylaminocarbonylalkyl” such as —CH 2 CON(CH 3 ) 2 , —CH 2 CON(CH 2 CH 3 ) 2 .
 
The “alkenylthio” refers to straight or branched chain alkenyl, which is linked to the structure by sulfur atom. Such as —SCH 2 CH═CH 2 . The “cycloalkyloxycarbonyl” means cyclopropyloxycarbonyl, cyclohexyloxycarbonyl, etc.
 
The “alkenoxylcarbonyl” means CH 2 ═CHCH 2 OCO—. The “alkynoxylcarbonyl” means —COOCH 2 C≡CH. The “alkoxyamino”: such as —NHOCH 3 . The “alkoxyalkoxycarbonyl”: such as —COOCH 2 CH 2 OCH 3 , etc. The “alkylaminothio” refers to —SNHCH 3 , —SNHC 2 H 5 . The “dialkylaminothio” refers to —SN(CH 3 ) 2 , —SN(C 2 H 5 ) 2 .
 
The “alkylcarbonylalkyl” refers to alkyl-CO-alkyl-. The “alkylsulfonylamino” refers to alkyl-SO 2 —NH—. The “haloalkylsulfonylamino” refers to straight or branched chain alkylsulfonylamino, in which hydrogen atoms can be all or partly substituted with halogen.
 
The “alkylsulfonylalkylamino” refers to alkyl-SO 2 -alkyl-NH—.
 
The “alkylaminosulfonyl” refers to alkyl-NH—SO 2 —. The“alkylcarbonylaminosulfonyl” refers to alkyl-CO—NH—SO 2 —. The “dialkylaminosulfonyl” refers to (alkyl) 2 -N—SO 2 —.
 
The “alkylthiocarbonylalkyl” refers to —CH 2 COSCH 3 , —CH 2 COSCH 2 CH 3 . The “haloalkylthiocarbonylalkyl” refers to —CH 2 COSCF 3 , —CH 2 COSCH 2 CF 3 .
 
The “alkylcarbonyloxy” such as —OCOCH 3 . The “haloalkylcarbonyloxy” such as —OCOCF 3 .
 
The “alkoxycarbonyloxy” such as —OCOOCH 3 . The “haloalkoxycarbonyloxy” such as —OCOOCF 3 . The “alkoxyalkoxy” stands for —OCH 2 OCH 3 . The “haloalkoxyalkoxy” stands for —OCH 2 OCF 3 . The “alkoxycarbonylalkoxy” stands for —OCH 2 COOCH 3 . The “alkylsulfonylaminocarbonyl” refers to alkyl-SO 2 —NH—CO—.
 
The “alkylcarbonylamino” refers to alkyl-CO—NH—. The “cycloalkyloxycarbonyl” means cyclopropyloxycarbonyl, cyclohexyloxycarbonyl. The “alkoxycarbonylalkoxy” stands for —OCH 2 COOCF 3 . The “alkylsulfonyloxy” such as alkyl-O—SO 2 CH 3 . The “haloalkylsulfonyloxy” such as —O—SO 2 CF 3 . The “alkylaminocarbonyloxy” such as —O—CONHCH 3 . The “haloalkylaminocarbonyloxy” such as —O—CONHCF 3 .
 
The “aryl” in (hetero)arylcarbonylalkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylalkyloxycarbonyl and (hetero)arylalkyl includes phenyl or naphthyl etc. The “heteroaryl” stands for five member ring or six member ring containing one or more N, O, S hetero atoms, such as furyl, pyrazolyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, quinolinyl, etc.
 
(Hetero)arylcarbonylalkyl refers to —CH 2 COPh, etc. (Hetero)aryloxycarbonyl such as phenoxycarbonyl, p-chlorophenoxycarbonyl, p-nitrophenoxycarbonyl, naphthyloxycarbonyl, etc. Arylalkyloxycarbonyl means benzyloxycarbonyl, p-chlorobenzyloxycarbonyl, p-trifluoromethylbenzyloxycarbonyl, etc.
 
     (Hetero)arylcarbonyl refers to benzoyl, 4-C 1 -benzoyl, etc. (Hetero)arylalkyloxycarbonyl refers to —COOCH 2 Ph, —COOCH 2 -4-Cl-Ph, etc. 
     (Hetero)arylalkyl means benzyl, phenylethyl, 4-chloro-benzyl, 2-chloro-5-picolyl, 2-chloro-5-methylthiazole, etc. 
     The present invention is also explained by the following compounds having a structure as represented by formula I listed in Table 1 to Table 118, but without being restricted thereby. 
     Table 1: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  refers to Table 1, the representative compounds are coded as I-1-I-58. 
     
       
                 
         
             
             
         
      
     
     
       
         
               
               
               
             
           
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 No. 
                 R 9   
               
               
                   
                   
               
             
             
               
                   
                 I-1 
                 H 
               
               
                   
                 I-2 
                 F 
               
               
                   
                 I-3 
                 Cl 
               
               
                   
                 I-4 
                 Br 
               
               
                   
                 I-5 
                 I 
               
               
                   
                 I-6 
                 CH 3   
               
               
                   
                 I-7 
                 Et 
               
               
                   
                 I-8 
                 n-Pr 
               
               
                   
                 I-9 
                 i-Pr 
               
               
                   
                 I-10 
                 n-Bu 
               
               
                   
                 I-11 
                 s-Bu 
               
               
                   
                 I-12 
                 t-Bu 
               
               
                   
                 I-13 
                 CH 2 F 
               
               
                   
                 I-14 
                 CH 2 Cl 
               
               
                   
                 I-15 
                 CH 2 Br 
               
               
                   
                 I-16 
                 CHF 2   
               
               
                   
                 I-17 
                 CHCl 2   
               
               
                   
                 I-18 
                 CHBr 2   
               
               
                   
                 I-19 
                 CClF 2   
               
               
                   
                 I-20 
                 CCl 3   
               
               
                   
                 I-21 
                 CBr 3   
               
               
                   
                 I-22 
                 CF 3   
               
               
                   
                 I-23 
                 CN 
               
               
                   
                 I-24 
                 CH 2 OCH 3   
               
               
                   
                 I-25 
                 CH 2 OCH 2 CF 3   
               
               
                   
                 I-26 
                 CH 2 N(CH 3 ) 2   
               
               
                   
                 I-27 
                 CH 2 CN 
               
               
                   
                 I-28 
                 OCH 3   
               
               
                   
                 I-29 
                 OCF 3   
               
               
                   
                 I-30 
                 OCH 2 CF 3   
               
               
                   
                 I-31 
                 SCH 3   
               
               
                   
                 I-32 
                 SO 2 CH 3   
               
               
                   
                 I-33 
                 CO 2 H 
               
               
                   
                 I-34 
                 CO 2 CH 3   
               
               
                   
                 I-35 
                 CO 2 C 2 H 5   
               
               
                   
                 I-36 
                 CO 2 CH 2 CF 3   
               
               
                   
                 I-37 
                 CO 2 -t-Bu 
               
               
                   
                 I-38 
                 CONH 2   
               
               
                   
                 I-39 
                 CONHCH 3   
               
               
                   
                 I-40 
                 CON(CH 3 ) 2   
               
               
                   
                 I-41 
                 CON(CH 3 ) 2   
               
               
                   
                 I-42 
                 CONHNHCH 3   
               
               
                   
                 I-43 
                 CONHN(CH 3 ) 2   
               
               
                   
                 I-44 
                 CONHOCH 3   
               
               
                   
                 I-45 
                 CONHNH 2   
               
               
                   
                 I-46 
                 CON(CH 3 )NH 2   
               
               
                   
                 I-47 
                 CONHNHCOCH 3   
               
               
                   
                 I-48 
                 CONHNHCO 2 CH 3   
               
               
                   
                 I-49 
                 CONHNH-Ph 
               
               
                   
                 I-50 
                 NO 2   
               
               
                   
                 I-51 
                 NH 2   
               
               
                   
                 I-52 
                 NHCH 3   
               
               
                   
                 I-53 
                 NHCH 2 CH 3   
               
               
                   
                 I-54 
                 NHCOCH 3   
               
               
                   
                 I-55 
                 NHCO 2 CH 3   
               
               
                   
                 I-56 
                 NHSO 2 CH 3   
               
               
                   
                 I-57 
                 NHSO 2 CF 3   
               
               
                   
                 I-58 
                 N(CH 3 )SO 2 CH 3   
               
               
                   
                   
               
             
          
         
       
     
     Table 2: in general formula I-A, R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-59-I-116. 
     Table 3: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-117-I-174. 
     Table 4: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-175-I-232. 
     Table 5: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-233-I-290. 
     Table 6: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-291-I-348. 
     Table 7: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-349-I-406. 
     Table 8: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-407-I-464. 
     Table 9: in general formula I-A, R 1 =CH 3 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-465-I-522. 
     Table 10: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-523-I-580. 
     Table 11: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-581-I-638. 
     Table 12: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-639-I-696. 
     Table 13: in general formula I-A, R 1 =CH 3 , R 2 =R 8 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-697-I-754. 
     Table 14: in general formula I-A, R 1 =CH 3 , R 2 =R 8 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-755-I-812. 
     Table 15: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 8 =R 1 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-813-I-870. 
     Table 16: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 8 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-871-I-928. 
     Table 17: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-929-I-986. 
     Table 18: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-987-I-1044. 
     Table 19: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 11 =CO 2 CH 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1045-I-1102. 
     Table 20: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 11 =CONH 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1103-I-1160. 
     Table 21: in general formula I-A, R 1 =CH 3 , R 2 =Cl, R 1 =CONHCH 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1161-I-1218. 
     Table 22: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 11 =CO 2 CH 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1219-I-1276. 
     Table 23: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 1 =CONH 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1277-I-1334. 
     Table 24: in general formula I-A, R 1 =C 2 H 5 , R 2 =Cl, R 11 =CONHCH 3 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1335-I-1392. 
     Table 25: in general formula I-A, R 1 =CH 3 , R 2 =R 5b =R 11 =Cl, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1393-I-1450. 
     Table 26: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 5b =R 11 =Cl, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1451-I-1508. 
     Table 27: in general formula I-A, R 1 =CH 3 , R 2 =R 11 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1509-I-1566. 
     Table 28: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 11 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1567-I-1624. 
     Table 29: in general formula I-A, R 1 =CH 3 , R 2 =R 1 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1625-I-1682. 
     Table 30: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 1 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1683-I-1740. 
     Table 31: in general formula I-A, R 1 =CH 3 , R 2 =Br, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1741-I-1798. 
     Table 32: in general formula I-A, R 1 =C 2 H 5 , R 2 =Br, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1799-I-1856. 
     Table 33: in general formula I-A, R 1 =CH 3 , R 2 =Br, R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1857-I-1914. 
     Table 34: in general formula I-A, R 1 =C 2 H 5 , R 2 =Br, R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1915-I-1972. 
     Table 35: in general formula I-A, R 1 =CH 3 , R 2 =Br, R 5b =Cl, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-1973-I-2030. 
     Table 36: in general formula I-A, R 1 =C 2 H 5 , R 2 =Br, R 5b =Cl, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2031-I-2088. 
     Table 37: in general formula I-A, R 1 =CH 3 , R 2 =R 5b =Br, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2089-I-2146. 
     Table 38: in general formula I-A, R 1 =C 2 H 5 , R 2 =R 5b =Br, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2147-I-2204. 
     Table 39: in general formula I-A, R 1 =CH 3 , R 2 =Br, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2205-I-2262. 
     Table 40: in general formula I-A, R 1 =C 2 H 5 , R 2 =Br, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2263-I-2320. 
     Table 41: in general formula I-A, R 1 =CF 2 H, R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2321-I-2378. 
     Table 42: in general formula I-A, R 1 =CF 2 H, R 2 =R 5b =Cl, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2379-I-2436. 
     Table 43: in general formula I-A, R 1 =CF 2 H, R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2437-I-2494. 
     Table 44: in general formula I-A, R 1 =CF 2 H, R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2495-I-2552. 
     Table 45: in general formula I-A, R 1 =CF 2 H, R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2553-I-2610. 
     Table 46: in general formula I-A, R 1 =CF 2 H, R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2611-I-2668. 
     Table 47: in general formula I-A, R 1 =CF 2 H, R 2 =R 11 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2669-I-2726. 
     Table 48: in general formula I-A, R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2727-I-2784. 
     Table 49: in general formula I-A, R 1 =CF 3 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2785-I-2842. 
     Table 50: in general formula I-A, R 1 =CF 3 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2843-I-2900. 
     Table 51: in general formula I-A, R 1 =CH 2 Cl, R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2901-I-2958. 
     Table 52: in general formula I-A, R 1 =CH 2 Cl, R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-2959-I-3016. 
     Table 53: in general formula I-A, R 1 =CH 2 Cl, R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3017-I-3074. 
     
       
                 
         
             
             
         
      
     
     Table 54: in general formula I-B, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3075-I-3132. 
     Table 55: in general formula I-B, R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3133-I-3190. 
     Table 56: in general formula I-B, R 1 =CH 3 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3191-I-3248. 
     Table 57: in general formula I-B, R 1 =CH 3 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3249-I-3306. 
     Table 58: in general formula I-B, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3307-I-3364. 
     Table 59: in general formula I-B, R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3365-I-3422. 
     Table 60: in general formula I-B, R 1 =C 2 H 5 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3423-I-3480. 
     Table 61: in general formula I-B, R 1 =C 2 H 5 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3481-I-3538. 
     Table 62: in general formula I-B, R 1 =CH 3 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3539-I-3596. 
     Table 63: in general formula I-B, R 1 =CH 3 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3597-I-3654. 
     Table 64: in general formula I-B, R 1 =C 2 H 5 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3655-I-3712. 
     Table 65: in general formula I-B, R 1 =C 2 H 5 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3713-I-3770. 
     Table 66: in general formula I-B, R 1 =CH 3 , R 2 =R 10 =Cl, R 3 =R 4 =R 5b =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3771-I-3828. 
     Table 67: in general formula I-B, R 1 =CH 3 , R 2 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3829-I-3886. 
     Table 68: in general formula I-B, R 1 =C 2 H 5 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3887-I-3944. 
     Table 69: in general formula I-B, R 1 =C 2 H 5 , R 2 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-3945-I-4002. 
     Table 70: in general formula I-B, R 1 =CH 3 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4003-I-4060. 
     Table 71: in general formula I-B, R 1 =C 2 H 5 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4061-I-4118. 
     Table 72: in general formula I-B, R 1 =CH 3 , R 2 =Br, R 3 =R 4 =R 5b =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4119-I-4176. 
     Table 73: in general formula I-B, R 1 =C 2 H 5 , R 2 =Br, R 3 =R 4 =R 5b =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4177-I-4234. 
     
       
                 
         
             
             
         
      
     
     Table 74: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4235-I-4292. 
     Table 75: in general formula I-C, R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4293-I-4350. 
     Table 76: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4351-I-4408. 
     Table 77: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4409-I-4466. 
     Table 78: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4467-I-4524. 
     Table 79: in general formula I-C, R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4525-I-4582. 
     Table 80: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4583-I-4640. 
     Table 81: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4641-I-4698. 
     Table 82: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =CH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4699-I-4756. 
     Table 83: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =OCH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4757-I-4814. 
     Table 84: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =Cl, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4815-I-4872. 
     Table 85: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =CH 3 , R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4873-I-4930. 
     Table 86: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =CH 3 , R 4 =R 5b =H, R 8 =R 10 =CH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4931-I-4988. 
     Table 87: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =CH 3 , R 4 =R 5b =H, R 8 =R 10 =OCH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-4989-I-5046. 
     Table 88: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 3 =CH 3 , R 4 =R 5b =H, R 8 =R 10 =Cl, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5047-I-5104. 
     Table 89: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 3 =CH 3 , R 4 =R 5b =R 8 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5105-I-5162. 
     Table 90: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =CH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5163-I-5220. 
     Table 91: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =OCH 3 , the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5221-I-5278. 
     Table 92: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =H, R 8 =R 10 =Cl, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5279-I-5336. 
     Table 93: in general formula I-C, R 1 =CH 3 , R 2 =R 8 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5337-I-5394. 
     Table 94: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 8 =CH 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5395-I-5452. 
     Table 95: in general formula I-C, R 1 =CH 3 , R 2 =Cl, R 8 =OCH 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5453-I-5510. 
     Table 96: in general formula I-C, R 1 =C 2 H 5 , R 2 =R 8 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5511-I-5568. 
     Table 97: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 8 =CH 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5569-I-5626. 
     Table 98: in general formula I-C, R 1 =C 2 H 5 , R 2 =Cl, R 8 =OCH 3 , R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5627-I-5684. 
     
       
                 
         
             
             
         
      
     
     Table 99: in general formula I-D, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5685-I-5742. 
     Table 100: in general formula I-D, R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5743-I-5800. 
     Table 101: in general formula I-D, R 1 =CH 3 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5801-I-5858. 
     Table 102: in general formula I-D, R 1 =CH 3 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5859-I-5916. 
     Table 103: in general formula I-D, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5917-I-5974. 
     Table 104: in general formula I-D, R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-5975-I-6032. 
     Table 105: in general formula I-D, R 1 =C 2 H 5 , R 2 =Cl, R 5b =Br, R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6033-I-6090. 
     Table 106: in general formula I-D, R 1 =C 2 H 5 , R 2 =Cl, R 5b =OCH 3 , R 3 =R 4 =R 7 =R 10 =R 11 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6091-I-6148. 
     Table 107: in general formula I-D, R 1 =CH 3 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6149-I-6206. 
     Table 108: in general formula I-D, R 1 =CH 3 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6207-I-6264. 
     Table 109: in general formula I-D, R 1 =C 2 H 5 , R 2 =R 11 =Cl, R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6265-I-6322. 
     Table 110: in general formula I-D, R 1 =C 2 H 5 , R 2 =Cl, R 11 =NO 2 , R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6323-I-6380. 
     Table 111: in general formula I-D, R 1 =CH 3 , R 2 =R 7 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6381-I-6438. 
     Table 112: in general formula I-D, R 1 =CH 3 , R 2 =R 7 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6439-I-6496. 
     Table 113: in general formula I-D, R 1 =C 2 H 5 , R 2 =R 7 =R 11 =Cl, R 3 =R 4 =R 5b =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6497-I-6554. 
     Table 114: in general formula I-D, R 1 =C 2 H 5 , R 2 =R 7 =R 10 =R 11 =Cl, R 3 =R 4 =R 5b =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6555-I-6612. 
     Table 115: in general formula I-D, R 1 =CH 3 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6613-I-6670. 
     Table 116: in general formula I-D, R 1 =C 2 H 5 , R 2 =Cl, R 11 =CF 3 , R 3 =R 4 =R 5b =R 7 =R 10 =H, the substituent R 9  are consistent with those in Table 1 and corresponding to I-1-I-58 in table 1 in turn, the representative compounds are coded as I-6671-I-6728. 
     Table 117: the salts of some compounds having a structure as represented by formula I of the present invention are listed in Table 117, but without being restricted thereby. 
     
       
         
               
             
               
               
             
           
               
                 TABLE 117 
               
             
             
               
                   
               
               
                 the salts of some compounds 
               
             
          
           
               
                 No. 
                 structure 
               
               
                   
               
               
                 I-6729 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6730 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6731 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6732 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6733 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6734 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6735 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6736 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6737 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6738 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6739 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6740 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6741 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6742 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6743 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6744 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6745 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6746 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6747 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6748 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6749 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6750 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6751 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6752 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6753 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6754 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6755 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6756 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6757 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6758 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6759 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6760 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6761 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6762 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6763 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6764 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6765 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6766 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6767 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6768 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6769 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6770 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6771 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6772 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6773 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6774 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6775 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6776 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6777 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6778 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6779 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6780 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6781 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6782 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     Some compounds represented by general formula I-E, I-F, I-G and I-H of the present invention are listed in Table 118, but without being restricted thereby. 
     
       
         
               
               
             
           
               
                 TABLE 118 
               
               
                   
               
               
                 No. 
                 structure 
               
               
                   
               
             
             
               
                 I-6783 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6784 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6785 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6786 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6787 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6788 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6789 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6790 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6791 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6792 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6793 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6794 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6795 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6796 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6797 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6798 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6799 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6800 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6801 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6802 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6803 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6804 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6805 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6806 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6807 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6808 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6809 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6810 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6811 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6812 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6813 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6814 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6815 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6816 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6817 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6818 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6819 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6820 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6821 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6822 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6823 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6824 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6825 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6826 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6827 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6828 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6829 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6830 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6831 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6832 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6833 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6834 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6835 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6836 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6837 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6838 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6839 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6840 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6841 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6842 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6843 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6844 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6845 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6846 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     In the general formula I, A=NR 12 , R 12 ≠H, part of preferred substituents of R 12  are listed in table 119, but without being restricted thereby. The present invention is also explained by the following compounds in the general formula I listed in Table 120, but without being restricted thereby. 
     
       
         
               
             
           
               
                 TABLE 119 
               
               
                   
               
               
                 R 12  substituents 
               
               
                 R 12   
               
               
                   
               
             
             
               
                 OH 
               
               
                 C 2 H 5   
               
               
                 i-C 4 H 9   
               
               
                 CHF 2   
               
               
                 CHCl 2   
               
               
                 OC 2 H 5   
               
               
                 OCH 2 CF 3   
               
               
                 SCH 3   
               
               
                 CH 2 CH═CH 2   
               
               
                 CH 2 C≡C—I 
               
               
                 CH 2 CH 2 OCH 2 CH 3   
               
               
                 CH 2 SCH 3   
               
               
                 CH 2 SCH 2 Cl 
               
               
                 SOC 2 H 5   
               
               
                 SO 2 C 2 H 5   
               
               
                 SO 2 NHCH 3   
               
               
                 COC 2 H 5   
               
               
                 CO-i-C 4 H 9   
               
               
                 COOCH 3   
               
               
                 COOCF 3   
               
               
                 CH 2 COOC 2 H 5   
               
               
                 CONHC 2 H 5   
               
               
                 COOCH 2 CH═CH 2   
               
               
                 SNHCH 3   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 —C(═O)H 
               
               
                 n-C 3 H 7   
               
               
                 t-C 4 H 9   
               
               
                 CHBr 2   
               
               
                 CCl 3   
               
               
                 OCH(CH 3 ) 2   
               
               
                 OCF 2 CF 3   
               
               
                 SC 2 H 5   
               
               
                 CH 2 CH═CCl 2   
               
               
                 CH 2 OCH 3   
               
               
                 CH 2 OCH 2 Cl 
               
               
                 CH 2 SCH 2 CH 3   
               
               
                 CH 2 SCH 2 CH 2 Cl 
               
               
                 SOCF 3   
               
               
                 SO 2 CF 3   
               
               
                 SO 2 N(CH 3 ) 3   
               
               
                 CO-n-C 3 H 7   
               
               
                 CO-t-C 4 H 9   
               
               
                 COOC 2 H 5   
               
               
                 COOCH 2 CH 2 Cl 
               
               
                 CH 2 COCH 3   
               
               
                 CONH-t-C 4 H 9   
               
               
                 COOCH 2 C≡CH 
               
               
                 SNHC 2 H 5   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CBr 3   
               
               
                 i-C 3 H 7   
               
               
                 CI 3   
               
               
                 CF 3   
               
               
                 CH 2 F 
               
               
                 OC(CH 3 ) 3   
               
               
                 OCH 2 F 
               
               
                 SCH 2 CH═CH 2   
               
               
                 C≡CH 
               
               
                 CH 2 OCH 2 CH 3   
               
               
                 CH 2 OCH 2 CH 2 Cl 
               
               
                 CH 2 CH 2 SCH 3   
               
               
                 CH 2 CH 2 SCH 2 Cl 
               
               
                 SOCH 2 CF 3   
               
               
                 SO 2 CH 2 CF 3   
               
               
                 CONHSO 2 CH 3   
               
               
                 CO-i-C 3 H 7   
               
               
                 COCF 3   
               
               
                 COO-n-C 3 H 7   
               
               
                 COOCH 2 CF 3   
               
               
                 CH 2 COC 2 H 5   
               
               
                 CON(CH 3 ) 2   
               
               
                 COOCH 2 OCH 3   
               
               
                 SN(CH 3 ) 2   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CH 3   
               
               
                 n-C 4 H 9   
               
               
                 CH 2 Br 
               
               
                 CH 2 Cl 
               
               
                 OCH 3   
               
               
                 OCF 3   
               
               
                 OCHF 2   
               
               
                 CH═CH 2   
               
               
                 CH 2 C≡CH 
               
               
                 CH 2 CH 2 OCH 3   
               
               
                 CH 2 CH 2 OCH 2 Cl 
               
               
                 CH 2 CH 2 SCH 2 CH 3   
               
               
                 SOCH 3   
               
               
                 SO 2 CH 3   
               
               
                 SO 2 NHCOCH 3   
               
               
                 COCH 3   
               
               
                 CO-n-C 4 H 9   
               
               
                 COCH 2 Cl 
               
               
                 COO-t-C 4 H 9   
               
               
                 CH 2 COOCH 3   
               
               
                 CONHCH 3   
               
               
                 CON(C 2 H 5 ) 2   
               
               
                 COOCH 2 CH 2 OCH 3   
               
               
                 SN(C 2 H 5 ) 2   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
             
           
               
                 TABLE 120 
               
               
                   
               
               
                 No. 
                 structure 
               
               
                   
               
             
             
               
                 I-6847 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6848 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6849 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6850 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6851 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6852 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6853 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6854 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6855 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6856 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6857 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6858 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6859 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6860 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6861 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6862 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6863 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6864 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6865 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6866 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6867 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6868 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6869 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6870 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6871 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6872 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6873 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6874 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6875 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6876 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6877 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6878 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6879 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6880 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6881 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6882 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6883 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6884 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6885 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6886 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6887 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6888 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6889 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6890 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6891 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6892 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6893 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 I-6894 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     In the general formula II, part of preferred substituents of R 1 , R 2 , R 3 (R 4 ), R 5a (R 5b , R 5c ), R 6 (R 7 , R 8 , R 9 , R 10 , R 11 ) and R 12  are separately listed in table 121, table 122, table 123, table 124, table 125 and table 126, but without being restricted thereby. 
     
       
                 
         
             
             
         
      
     
     
       
         
               
             
           
               
                 TABLE 121 
               
               
                   
               
               
                 R 1  substituents 
               
               
                 R 1   
               
               
                   
               
             
             
               
                 CH 3   
               
               
                 n-C 4 H 9   
               
               
                 CF 3   
               
               
                 CH 2 Br 
               
               
                 CF 2 H 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 C 2 H 5   
               
               
                 s-C 4 H 9   
               
               
                 CCl 3   
               
               
                 CClF 2   
               
               
                 CBr 2 H 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 n-C 3 H 7   
               
               
                 i-C 4 H 9   
               
               
                 CH 2 F 
               
               
                 CFCl 2   
               
               
                 CBr 3   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 i-C 3 H 7   
               
               
                 t-C 4 H 9   
               
               
                 CH 2 Cl 
               
               
                 CCl 2 H 
               
               
                 CClBr 2   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 122 
               
             
             
               
                   
               
               
                 R 2  substituents 
               
             
          
           
               
                   
                 R 2   
                 R 2   
                 R 2   
                 R 2   
               
               
                   
                   
               
               
                   
                 F 
                 Cl 
                 Br 
                 I 
               
               
                   
                 CN 
                 OCH 3   
                 OC 2 H 5   
                 OC 3 H 7 -n 
               
               
                   
                 OC 3 H 7 -i 
                 OC 4 H 9 -n 
                 OC 4 H 9 -i 
                 OC 4 H 9 -t 
               
               
                   
                   
               
             
          
         
       
     
     
       
         
               
             
           
               
                 TABLE 123 
               
               
                   
               
               
                 R 3 (R 4 ) substituents 
               
               
                   
               
             
             
               
                 R 3 (R 4 ) 
               
               
                   
               
               
                 H 
               
               
                 i-C 3 H 7   
               
               
                 F 
               
               
                 t-C 4 H 9   
               
               
                 OCH 3   
               
               
                 CH 3   
               
               
                 n-C 4 H 9   
               
               
                 Cl 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 OC 2 H 5   
               
               
                 C 2 H 5   
               
               
                 s-C 4 H 9   
               
               
                 Br 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 OC 3 H 7 -n 
               
               
                 n-C 3 H 7   
               
               
                 i-C 4 H 9   
               
               
                 I 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 OC 3 H 7 -i 
               
               
                   
               
               
                 CR 3 (R 4 ) 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 124 
               
             
             
               
                   
               
               
                 R 5a  (R 5b , R 5c ) substituents 
               
             
          
           
               
                 R 5a  (R 5b , R 5c ) 
                 R 5a  (R 5b , R 5c ) 
                 R 5a  (R 5b , R 5c ) 
                 R 5a  (R 5b , R 5c ) 
               
               
                   
               
               
                 H 
                 CH 3   
                 i-C 4 H 9   
                 OC 4 H 9 -n 
               
               
                 F 
                 C 2 H 5   
                 t-C 4 H 9   
                 OC 4 H 9 -i 
               
               
                 Cl 
                 n-C 3 H 7   
                 OCH 3   
                 OC 4 H 9 -t 
               
               
                 Br 
                 i-C 3 H 7   
                 OC 2 H 5   
                 OCF 3   
               
               
                 I 
                 n-C 4 H 9   
                 OC 3 H 7 -n 
                 OCH 2 CF 3   
               
               
                 OH 
                 s-C 4 H 9   
                 OC 3 H 7 -i 
                 OCF 2 CF 3   
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 125 
               
             
             
               
                   
               
               
                 R 6  (R 7 , R 8 , R 9 , R 10 , R 11 ) substituents 
               
             
          
           
               
                 R 6  (R 7 , R 8 , 
                   
                   
                   
                   
               
               
                 R 9 , R 10 , 
                 R 6  (R 7 , R 8 , 
                 R 6  (R 7 , R 8 , R 9 , 
                 R 6  (R 7 , R 8 , R 9 , 
               
               
                 R 11 ) 
                 R 9 , R 10 , R 11 ) 
                 R 10 , R 11 ) 
                 R 10 , R 11 ) 
                 R 6  (R 7 , R 8 , R 9 , R 10 , R 11 ) 
               
               
                   
               
               
                 H 
                 4-CH 3   
                 3-CH 2 OCH 3   
                 2,6-2Cl-4-CONH 2   
                 2-CF 3 -4-Br-6-NO 2   
               
               
                 2-F 
                 2,3-2CH 3   
                 4-CH 2 OCH 3   
                 2,4-2Cl-6-NO 2   
                 3-NO 2 -4-CF 3   
               
               
                 3-F 
                 2,4-2CH 3   
                 2-OCOCH 3   
                 2,4-2Cl-6-CN 
                 2-NO 2 -4-CN-5-CF 3   
               
               
                 4-F 
                 2,5-2CH 3   
                 3-OCOCH 3   
                 2,4-2Cl-6-CF 3   
                 2-NO 2 -4-CF 3 -5-CN 
               
               
                 2,3-2F 
                 2,6-2CH 3   
                 4-OCOCH 3   
                 2,4-2F-6-NO 2   
                 4-OCF 3 -2,6-2Br 
               
               
                 2,4-2F 
                 3,4-2CH 3   
                 2-OCOCH 2 CH 3   
                 2,6-2F-4-NO 2   
                 2-CH 3 -4-Cl-5-CH 2 CO 2 C 2 H 5   
               
               
                 2,5-2F 
                 3,5-2CH 3   
                 3-OCOCH 2 CH 3   
                 2-NO 2 -4-F 
                 2,4-2Cl-3-CH 3   
               
               
                 2,6-2F 
                 2-C 2 H 5   
                 4-OCOCH 2 CH 3   
                 2-NO 2 -4-Br 
                 2,4-2Cl-3-CH 3 -6-NO 2   
               
               
                 3,4-2F 
                 3-C 2 H 5   
                 2-OCO 2 CH 3   
                 2-NO 2 -4-CF 3   
                 2-Cl-3-CH 3   
               
               
                 3,5-2F 
                 4-C 2 H 5   
                 3-OCO 2 CH 3   
                 2-NO 2 -4-CN 
                 2-CH 3 -3-Cl 
               
               
                 2,3,4-3F 
                 2-CF 3   
                 4-OCO 2 CH 3   
                 2-NO 2 -4-COCH 3   
                 2-CH 3 -3-Cl-4,6-2NO 2   
               
               
                 2,3,5-3F 
                 3-CF 3   
                 2-OCH 2 OCH 3   
                 2-NO 2 -4-CONH 2   
                 2-CH 3 -3-Cl-4-NO 2   
               
               
                 2,4,5-3F 
                 4-CF 3   
                 3-OCH 2 OCH 3   
                 2-NO 2 -4-CH 3   
                 2-CH 3 -3-Cl-6-NO 2   
               
               
                 2,3,6-3F 
                 2-OCH 3   
                 4-OCH 2 OCH 3   
                 2-NO 2 -4-OCH 3   
                 2-Cl-3-CH 3 -4,6-2NO 2   
               
               
                 2,4,6-3F 
                 3-OCH 3   
                 2-OCF 2 OCF 3   
                 2-NO 2 -4-SCH 3   
                 2-Cl-3-CH 3 -4-NO 2   
               
               
                 3,4,5-3F 
                 4-OCH 3   
                 3-OCF 2 OCF 3   
                 2-NO 2 -4-NCH 3   
                 2-Cl-3-CH 3 -6-NO 2   
               
               
                 2-Cl 
                 2-SCH 3   
                 4-OCF 2 OCF 3   
                 2-F-4-NO 2   
                 2-Br-4-NO 2 -6-CN 
               
               
                 3-Cl 
                 3-SCH 3   
                 2-COPh 
                 2-Br-4-NO 2   
                 3-Cl-4-CF 3 -2,6-2NO 2   
               
               
                 4-Cl 
                 4-SCH 3   
                 3-COPh 
                 2-CF 3 -4-NO 2   
                 2NO 2 -4,5-2Cl 
               
               
                 2,3-2Cl 
                 2-OCF 3   
                 4-COPh 
                 2-CN-4-NO 2   
                 2-NO 2 -3,5-2Cl 
               
               
                 2,4-2Cl 
                 3-OCF 3   
                 2-COCH 2 Ph 
                 2-COCH 3 -4-NO 2   
                 2,5-2Cl-4-NO 2   
               
               
                 2,5-2Cl 
                 4-OCF 3   
                 3-COCH 2 Ph 
                 2-CONH 2 -4-NO 2   
                 2,5-2Cl-6-NO 2   
               
               
                 2,6-2Cl 
                 2-SCF 3   
                 4-COCH 2 Ph 
                 2-CH 3 -4-NO 2   
                 2,3-2Cl-4-NO 2   
               
               
                 3,4-2Cl 
                 3-SCF 3   
                 2-NHPh 
                 2-Cl-4-F-6-NO 2   
                 2,3-2Cl-6-NO 2   
               
               
                 3,5-2Cl 
                 4-SCF 3   
                 3-NHPh 
                 2-Cl-4-Br-6-NO 2   
                 3,4-2Cl-2,6-2NO 2   
               
               
                 2,3,4-3Cl 
                 2-OC 2 H 5   
                 4-NHPh 
                 2-Cl-4-CH 3 -6-NO 2   
                 2,5-2Cl-4,6-2NO 2   
               
               
                 2,3,5-3Cl 
                 3-OC 2 H 5   
                 2-OPh 
                 2-Cl-4-CF 3 -6-NO 2   
                 2,4,5-3Cl-6-NO 2   
               
               
                 2,4,5-3Cl 
                 4-OC 2 H 5   
                 3-OPh 
                 2-Cl-4,6-2NO 2   
                 2,3,4-3Cl-5-NO 2   
               
               
                 2,3,6-3Cl 
                 2-NHCH 3   
                 4-OPh 
                 2-Cl-4-CN-6-NO 2   
                 2,3,4-3Cl-6-NO 2   
               
               
                 2,4,6-3Cl 
                 3-NHCH 3   
                 2-CONHPh 
                 2-Cl-4-OCF 3 -6-NO 2   
                 2,3,5-3Cl-4,6-2CN 
               
               
                 3,4,5-3Cl 
                 4-NHCH 3   
                 3-CONHPh 
                 2-F-4-Cl-6-NO 2   
                 2,5-2Cl-4-OCF 2 OCF 3   
               
               
                 2-Br 
                 2-N(CH 3 ) 2   
                 4-CONHPh 
                 2-Br-4-Cl-6-NO 2   
                 2,6-2Br-4-NO 2   
               
               
                 3-Br 
                 3-N(CH 3 ) 2   
                 2-CO 2 Ph 
                 2-CH 3 -4-Cl-6-NO 2   
                 2-F-4-NO 2 -6-Cl 
               
               
                 4-Br 
                 4-N(CH 3 ) 2   
                 3-CO 2 Ph 
                 2-CF 3 -4-Cl-6-NO 2   
                 2-Cl-4-NO 2 -6-SCN 
               
               
                 2,3-2Br 
                 2-COCH 3   
                 4-CO 2 Ph 
                 4-Cl-2,6-2NO 2   
                 2-Br-4-NO 2 -6-Cl 
               
               
                 2,4-2Br 
                 3-COCH 3   
                 2-CONH 2   
                 2-F-4-CN 
                 2-Cl-4-NO 2 -6-OCH 3   
               
               
                 2,5-2Br 
                 4-COCH 3   
                 3-CONH 2   
                 2-CN-4-CF 3   
                 2-Cl-4-NO 2 -6-SCH 3   
               
               
                 2,6-2Br 
                 2-COC 2 H 5   
                 4-CONH 2   
                 4-CF 3 -2,6-2NO 2   
                 2-Cl-4-NO 2 -6-NHCH 3   
               
               
                 3,4-2Br 
                 3-COC 2 H 5   
                 2-Cl-4-F 
                 4-CN-2,6-2NO 2   
                 2-Cl-4-NO 2 -6-SO 2 CH 3   
               
               
                 3,5-2Br 
                 4-COC 2 H 5   
                 2-Cl-4-Br 
                 4-CH 3 -2,6-2NO 2   
                 2-Cl-4-SO 2 CH 3   
               
               
                 2,3,4-3Br 
                 2-SO 2 CH 3   
                 2-Cl-4-CH 3   
                 4-OCF 3 -2,6-2NO 2   
                 2,6-2Cl-4-SO 2 CH 3   
               
               
                 2,3,5-3Br 
                 3-SO 2 CH 3   
                 2-Cl-4-CF 3   
                 4-OCH 3 -2,6-2NO 2   
                 2,6-2Cl-4-CH 3   
               
               
                 2,4,5-3Br 
                 4-SO 2 CH 3   
                 2-Cl-4-NO 2   
                 4-SCH 3 -2,6-2NO 2   
                 2,6-2Cl-4-CO 2 CH 3   
               
               
                 2,3,6-3Br 
                 2-OCHF 2   
                 2-Cl-4-CN 
                 4-NHCH 3 -2,6-2NO 2   
                 2,6-2Cl-4-CONHCH 3   
               
               
                 2,4,6-3Br 
                 3-OCHF 2   
                 2-Cl-4-OCF 3   
                 4-F-2,6-2NO 2   
                 2,6-2Cl-4-CON(CH 3 ) 2   
               
               
                 3,4,5-3Br 
                 4-OCHF 2   
                 2-F-4-Cl 
                 2-CF 3 -4,6-2NO 2   
                 2,6-2Cl-4-CF(CF 3 ) 2   
               
               
                 2-CN 
                 2-SO 2 C 2 H 5   
                 2-Br-4-Cl 
                 2-CN-4,6-2NO 2   
                 2-Cl-4-CF(CF 3 ) 2 -6-Br 
               
               
                 3-CN 
                 3-SO 2 C 2 H 5   
                 2-CH 3 -4-Cl 
                 2-CH 3 -4,6-2NO 2   
                 2-F-4-CF(CF 3 ) 2 -6-Br 
               
               
                 4-CN 
                 4-SO 2 C 2 H 5   
                 2-CF 3 -4-Cl 
                 2-F-4,6-2NO 2   
                 2-F-4-CF(CF 3 ) 2 -6-Cl 
               
               
                 2-NO 2   
                 2-CO 2 CH 3   
                 2-NO 2 -4-Cl 
                 2-OCF 3 -4,6-2NO 2   
                 2,4,5-3Cl-3,6-2CN 
               
               
                 3-NO 2   
                 3-CO 2 CH 3   
                 2-CN-4-Cl 
                 2-CF 3 -4-Br 
                 2,3,5-3F-4,6-2CN 
               
               
                 4-NO 2   
                 4-CO 2 CH 3   
                 2-OCF 3 -4-Cl 
                 3-CF 3 -4-NO 2   
                 2-SO 2 NH 2   
               
               
                 2,4-2NO 2   
                 2-CO 2 C 2 H 5   
                 2,6-2Cl-4-NO 2   
                 2-CN-4-Cl-6-NO 2   
                 3-SO 2 NH 2   
               
               
                 2,4,6-3NO 2   
                 3-CO 2 C 2 H 5   
                 2,6-2Cl-4-CF 3   
                 2-OCF 3 -4-Cl-6-NO 2   
                 4-SO 2 NH 2   
               
               
                 2-CH 3   
                 4-CO 2 C 2 H 5   
                 2,6-2Cl-4-CN 
                 3-CF 3 -4-CN 
               
               
                 3-CH 3   
                 2-CH 2 OCH 3   
                 2,6-2Cl-4-COCH 3   
                 3-CN-4-CF 3   
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 126 
               
             
             
               
                   
               
               
                 R 12  substituents 
               
             
          
           
               
                   
                 R 12   
                 R 12   
                 R 12   
                 R 12   
               
               
                   
                   
               
               
                   
                 H 
                 OH 
                 CH 3   
                 C 2 H 5   
               
               
                   
                 n-C 3 H 7   
                 i-C 3 H 7   
                 n-C 4 H 9   
                 s-C 4 H 9   
               
               
                   
                 i-C 4 H 9   
                 t-C 4 H 9   
                 HCO 
                 CH 3 CO 
               
               
                   
                 CH 3 CH 2 CO 
                 n-C 3 H 7 CO 
                 i-C 3 H 7 CO 
                 CH 3 SO 2   
               
               
                   
                 CH 3 CH 2 SO 2   
                 n-C 3 H 7 SO 2   
                 n-C 4 H 9 SO 2   
               
               
                   
                   
               
             
          
         
       
     
     The present invention is also explained by the following compounds having a structure as represented by formula II listed in Table 127 to Table 202, Compounds having a structure as represented by formula II-A are listed in Table 127 to Table 190, Compounds having a structure as represented by formula II-B are listed in Table 191 to Table 201, but without being restricted thereby. 
     
       
                 
         
             
             
         
      
     
     In general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  refer to Table 127, the representative compounds are coded as II-1-II-2780 
     
       
         
               
               
               
               
               
               
             
           
               
                 TABLE 127 
               
               
                   
               
               
                 No. 
                 R 7   
                 R 8   
                 R 9   
                 R 10   
                 R 11   
               
               
                   
               
             
             
               
                 II-1 
                 H 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-2 
                 F 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-3 
                 H 
                 F 
                 H 
                 H 
                 H 
               
               
                 II-4 
                 H 
                 H 
                 F 
                 H 
                 H 
               
               
                 II-5 
                 F 
                 F 
                 H 
                 H 
                 H 
               
               
                 II-6 
                 F 
                 H 
                 F 
                 H 
                 H 
               
               
                 II-7 
                 F 
                 H 
                 H 
                 F 
                 H 
               
               
                 II-8 
                 F 
                 H 
                 H 
                 H 
                 F 
               
               
                 II-9 
                 H 
                 F 
                 F 
                 H 
                 H 
               
               
                 II-10 
                 H 
                 F 
                 H 
                 F 
                 H 
               
               
                 II-11 
                 F 
                 F 
                 F 
                 H 
                 H 
               
               
                 II-12 
                 F 
                 F 
                 H 
                 F 
                 H 
               
               
                 II-13 
                 F 
                 H 
                 F 
                 F 
                 H 
               
               
                 II-14 
                 F 
                 F 
                 H 
                 H 
                 F 
               
               
                 II-15 
                 F 
                 H 
                 F 
                 H 
                 F 
               
               
                 II-16 
                 H 
                 F 
                 F 
                 F 
                 H 
               
               
                 II-17 
                 Cl 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-18 
                 H 
                 Cl 
                 H 
                 H 
                 H 
               
               
                 II-19 
                 H 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-20 
                 Cl 
                 Cl 
                 H 
                 H 
                 H 
               
               
                 II-21 
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-22 
                 Cl 
                 H 
                 H 
                 Cl 
                 H 
               
               
                 II-23 
                 Cl 
                 H 
                 H 
                 H 
                 Cl 
               
               
                 II-24 
                 H 
                 Cl 
                 Cl 
                 H 
                 H 
               
               
                 II-25 
                 H 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                 II-26 
                 Cl 
                 Cl 
                 Cl 
                 H 
                 H 
               
               
                 II-27 
                 Cl 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                 II-28 
                 Cl 
                 H 
                 Cl 
                 Cl 
                 H 
               
               
                 II-29 
                 Cl 
                 Cl 
                 H 
                 H 
                 Cl 
               
               
                 II-30 
                 Cl 
                 H 
                 Cl 
                 H 
                 Cl 
               
               
                 II-31 
                 H 
                 Cl 
                 Cl 
                 Cl 
                 H 
               
               
                 II-32 
                 Br 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-33 
                 H 
                 Br 
                 H 
                 H 
                 H 
               
               
                 II-34 
                 H 
                 H 
                 Br 
                 H 
                 H 
               
               
                 II-35 
                 Br 
                 Br 
                 H 
                 H 
                 H 
               
               
                 II-36 
                 Br 
                 H 
                 Br 
                 H 
                 H 
               
               
                 II-37 
                 Br 
                 H 
                 H 
                 Br 
                 H 
               
               
                 II-38 
                 Br 
                 H 
                 H 
                 H 
                 Br 
               
               
                 II-39 
                 H 
                 Br 
                 Br 
                 H 
                 H 
               
               
                 II-40 
                 H 
                 Br 
                 H 
                 Br 
                 H 
               
               
                 II-41 
                 Br 
                 Br 
                 Br 
                 H 
                 H 
               
               
                 II-42 
                 Br 
                 Br 
                 H 
                 Br 
                 H 
               
               
                 II-43 
                 Br 
                 H 
                 Br 
                 Br 
                 H 
               
               
                 II-44 
                 Br 
                 Br 
                 H 
                 H 
                 Br 
               
               
                 II-45 
                 Br 
                 H 
                 Br 
                 H 
                 Br 
               
               
                 II-46 
                 H 
                 Br 
                 Br 
                 Br 
                 H 
               
               
                 II-47 
                 CN 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-48 
                 H 
                 CN 
                 H 
                 H 
                 H 
               
               
                 II-49 
                 H 
                 H 
                 CN 
                 H 
                 H 
               
               
                 II-50 
                 NO 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-51 
                 H 
                 NO 2   
                 H 
                 H 
                 H 
               
               
                 II-52 
                 H 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-53 
                 NO 2   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-54 
                 NO 2   
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-55 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-56 
                 H 
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-57 
                 H 
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 II-58 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-59 
                 CH 3   
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 II-60 
                 CH 3   
                 H 
                 H 
                 CH 3   
                 H 
               
               
                 II-61 
                 CH 3   
                 H 
                 H 
                 H 
                 CH 3   
               
               
                 II-62 
                 H 
                 CH 3   
                 CH 3   
                 H 
                 H 
               
               
                 II-63 
                 H 
                 CH 3   
                 H 
                 CH 3   
                 H 
               
               
                 II-64 
                 C 2 H 5   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-65 
                 H 
                 C 2 H 5   
                 H 
                 H 
                 H 
               
               
                 II-66 
                 H 
                 H 
                 C 2 H 5   
                 H 
                 H 
               
               
                 II-67 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-68 
                 H 
                 CF 3   
                 H 
                 H 
                 H 
               
               
                 II-69 
                 H 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 II-70 
                 OCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-71 
                 H 
                 OCH 3   
                 H 
                 H 
                 H 
               
               
                 II-72 
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                 II-73 
                 SCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-74 
                 H 
                 SCH 3   
                 H 
                 H 
                 H 
               
               
                 II-75 
                 H 
                 H 
                 SCH 3   
                 H 
                 H 
               
               
                 II-76 
                 OCF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-77 
                 H 
                 OCF 3   
                 H 
                 H 
                 H 
               
               
                 II-78 
                 H 
                 H 
                 OCF 3   
                 H 
                 H 
               
               
                 II-79 
                 SCF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-80 
                 H 
                 SCF 3   
                 H 
                 H 
                 H 
               
               
                 II-81 
                 H 
                 H 
                 SCF 3   
                 H 
                 H 
               
               
                 II-82 
                 OC 2 H 5   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-83 
                 H 
                 OC 2 H 5   
                 H 
                 H 
                 H 
               
               
                 II-84 
                 H 
                 H 
                 OC 2 H 5   
                 H 
                 H 
               
               
                 II-85 
                 NHCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-86 
                 H 
                 NHCH 3   
                 H 
                 H 
                 H 
               
               
                 II-87 
                 H 
                 H 
                 NHCH 3   
                 H 
                 H 
               
               
                 II-88 
                 N(CH 3 ) 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-89 
                 H 
                 N(CH 3 ) 2   
                 H 
                 H 
                 H 
               
               
                 II-90 
                 H 
                 H 
                 N(CH 3 ) 2   
                 H 
                 H 
               
               
                 II-91 
                 COCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-92 
                 H 
                 COCH 3   
                 H 
                 H 
                 H 
               
               
                 II-93 
                 H 
                 H 
                 COCH 3   
                 H 
                 H 
               
               
                 II-94 
                 COC 2 H 5   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-95 
                 H 
                 COC 2 H 5   
                 H 
                 H 
                 H 
               
               
                 II-96 
                 H 
                 H 
                 COC 2 H 5   
                 H 
                 H 
               
               
                 II-97 
                 SO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-98 
                 H 
                 SO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-99 
                 H 
                 H 
                 SO 2 CH 3   
                 H 
                 H 
               
               
                 II-100 
                 OCHF 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-101 
                 H 
                 OCHF 2   
                 H 
                 H 
                 H 
               
               
                 II-102 
                 H 
                 H 
                 OCHF 2   
                 H 
                 H 
               
               
                 II-103 
                 SO 2 C 2 H 5   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-104 
                 H 
                 SO 2 C 2 H 5   
                 H 
                 H 
                 H 
               
               
                 II-105 
                 H 
                 H 
                 SO 2 C 2 H 5   
                 H 
                 H 
               
               
                 II-106 
                 CO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-107 
                 H 
                 CO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-108 
                 H 
                 H 
                 CO 2 CH 3   
                 H 
                 H 
               
               
                 II-109 
                 CO 2 C 2 H 5   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-110 
                 H 
                 CO 2 C 2 H 5   
                 H 
                 H 
                 H 
               
               
                 II-111 
                 H 
                 H 
                 CO 2 C 2 H 5   
                 H 
                 H 
               
               
                 II-112 
                 CH 2 OCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-113 
                 H 
                 CH 2 OCH 3   
                 H 
                 H 
                 H 
               
               
                 II-114 
                 H 
                 H 
                 CH 2 OCH 3   
                 H 
                 H 
               
               
                 II-115 
                 OCOCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-116 
                 H 
                 OCOCH 3   
                 H 
                 H 
                 H 
               
               
                 II-117 
                 H 
                 H 
                 OCOCH 3   
                 H 
                 H 
               
               
                 II-118 
                 OCOCH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-119 
                 H 
                 OCOCH 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-120 
                 H 
                 H 
                 OCOCH 2 CH 3   
                 H 
                 H 
               
               
                 II-121 
                 OCO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-122 
                 H H 
                 OCO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-123 
                 H 
                 H 
                 OCO 2 CH 3   
                 H 
                 H 
               
               
                 II-124 
                 OCH 2 OCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-125 
                 H 
                 OCH 2 OCH 3   
                 H 
                 H 
                 H 
               
               
                 II-126 
                 H 
                 H 
                 OCH 2 OCH 3   
                 H 
                 H 
               
               
                 II-127 
                 OCF 2 OCF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-128 
                 H 
                 OCF 2 OCF 3   
                 H 
                 H 
                 H 
               
               
                 II-129 
                 H 
                 H 
                 OCF 2 OCF 3   
                 H 
                 H 
               
               
                 II-130 
                 COPh 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-131 
                 H 
                 COPh 
                 H 
                 H 
                 H 
               
               
                 II-132 
                 H 
                 H 
                 COPh 
                 H 
                 H 
               
               
                 II-133 
                 COCH 2 Ph 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-134 
                 H 
                 COCH 2 Ph 
                 H 
                 H 
                 H 
               
               
                 II-135 
                 H 
                 H 
                 COCH 2 Ph 
                 H 
                 H 
               
               
                 II-136 
                 NHPh 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-137 
                 H 
                 NHPh 
                 H 
                 H 
                 H 
               
               
                 II-138 
                 H 
                 H 
                 NHPh 
                 H 
                 H 
               
               
                 II-139 
                 OPh 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-140 
                 H 
                 OPh 
                 H 
                 H 
                 H 
               
               
                 II-141 
                 H 
                 H 
                 OPh 
                 H 
                 H 
               
               
                 II-142 
                 CONHPh 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-143 
                 H 
                 CONHPh 
                 H 
                 H 
                 H 
               
               
                 II-144 
                 H 
                 H 
                 CONHPh 
                 H 
                 H 
               
               
                 II-145 
                 CO 2 Ph 
                 H 
                 H 
                 H 
                 H 
               
               
                 II-146 
                 H 
                 CO 2 Ph 
                 H 
                 H 
                 H 
               
               
                 II-147 
                 H 
                 H 
                 CO 2 Ph 
                 H 
                 H 
               
               
                 II-148 
                 CONH 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-149 
                 H 
                 CONH 2   
                 H 
                 H 
                 H 
               
               
                 II-150 
                 H 
                 H 
                 CONH 2   
                 H 
                 H 
               
               
                 II-151 
                 Cl 
                 H 
                 F 
                 H 
                 H 
               
               
                 II-152 
                 Cl 
                 H 
                 Br 
                 H 
                 H 
               
               
                 II-153 
                 Cl 
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 II-154 
                 Cl 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 II-155 
                 Cl 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-156 
                 Cl 
                 H 
                 CN 
                 H 
                 H 
               
               
                 II-157 
                 Cl 
                 H 
                 OCF 3   
                 H 
                 H 
               
               
                 II-158 
                 F 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-159 
                 Br 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-160 
                 CH 3   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-161 
                 CF 3   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-162 
                 NO 2   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-163 
                 CN 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-164 
                 OCF 3   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 II-165 
                 Cl 
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                 II-166 
                 Cl 
                 H 
                 CF 3   
                 H 
                 Cl 
               
               
                 II-167 
                 Cl 
                 H 
                 CN 
                 H 
                 Cl 
               
               
                 II-168 
                 Cl 
                 H 
                 COCH 3   
                 H 
                 Cl 
               
               
                 II-169 
                 Cl 
                 H 
                 CONH 2   
                 H 
                 Cl 
               
               
                 II-170 
                 Cl 
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-171 
                 Cl 
                 H 
                 Cl 
                 H 
                 CN 
               
               
                 II-172 
                 Cl 
                 H 
                 Cl 
                 H 
                 CF 3   
               
               
                 II-173 
                 F 
                 H 
                 F 
                 H 
                 NO 2   
               
               
                 II-174 
                 F 
                 H 
                 NO 2   
                 H 
                 F 
               
               
                 II-175 
                 NO 2   
                 H 
                 F 
                 H 
                 H 
               
               
                 II-176 
                 NO 2   
                 H 
                 Br 
                 H 
                 H 
               
               
                 II-177 
                 NO 2   
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 II-178 
                 NO 2   
                 H 
                 CN 
                 H 
                 H 
               
               
                 II-179 
                 NO 2   
                 H 
                 COCH 3   
                 H 
                 H 
               
               
                 II-180 
                 NO 2   
                 H 
                 CONH 2   
                 H 
                 H 
               
               
                 II-181 
                 NO 2   
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 II-182 
                 NO 2   
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                 II-183 
                 NO 2   
                 H 
                 SCH 3   
                 H 
                 H 
               
               
                 II-184 
                 NO 2   
                 H 
                 NCH 3   
                 H 
                 H 
               
               
                 II-185 
                 F 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-186 
                 Br 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-187 
                 CF 3   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-188 
                 CN 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-189 
                 COCH 3   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-190 
                 CONH 2   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-191 
                 CH 3   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 II-192 
                 Cl 
                 H 
                 F 
                 H 
                 NO 2   
               
               
                 II-193 
                 Cl 
                 H 
                 Br 
                 H 
                 NO 2   
               
               
                 II-194 
                 Cl 
                 H 
                 CH 3   
                 H 
                 NO 2   
               
               
                 II-195 
                 Cl 
                 H 
                 CF 3   
                 H 
                 NO 2   
               
               
                 II-196 
                 Cl 
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-197 
                 Cl 
                 H 
                 CN 
                 H 
                 NO 2   
               
               
                 II-198 
                 Cl 
                 H 
                 OCF 3   
                 H 
                 NO 2   
               
               
                 II-199 
                 F 
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-200 
                 Br 
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-201 
                 CH 3   
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-202 
                 CF 3   
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-203 
                 NO 2   
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-204 
                 F 
                 H 
                 CN 
                 H 
                 H 
               
               
                 II-205 
                 CN 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 II-206 
                 NO 2   
                 H 
                 CF 3   
                 H 
                 NO 2   
               
               
                 II-207 
                 NO 2   
                 H 
                 CN 
                 H 
                 NO 2   
               
               
                 II-208 
                 NO 2   
                 H 
                 CH 3   
                 H 
                 NO 2   
               
               
                 II-209 
                 NO 2   
                 H 
                 OCF 3   
                 H 
                 NO 2   
               
               
                 II-210 
                 NO 2   
                 H 
                 OCH 3   
                 H 
                 NO 2   
               
               
                 II-211 
                 NO 2   
                 H 
                 SCH 3   
                 H 
                 NO 2   
               
               
                 II-212 
                 NO 2   
                 H 
                 NHCH 3   
                 H 
                 NO 2   
               
               
                 II-213 
                 NO 2   
                 H 
                 F 
                 H 
                 NO 2   
               
               
                 II-214 
                 CF 3   
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-215 
                 CN 
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-216 
                 CH 3   
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-217 
                 F 
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-218 
                 OCF 3   
                 H 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-219 
                 CF 3   
                 H 
                 Br 
                 H 
                 H 
               
               
                 II-220 
                 H 
                 CF 3   
                 NO 2   
                 H 
                 H 
               
               
                 II-221 
                 CN 
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-222 
                 OCF 3   
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-223 
                 H 
                 CF 3   
                 CN 
                 H 
                 H 
               
               
                 II-224 
                 H 
                 CN 
                 CF 3   
                 H 
                 H 
               
               
                 II-225 
                 CF 3   
                 H 
                 Br 
                 H 
                 NO 2   
               
               
                 II-226 
                 H 
                 NO 2   
                 CF 3   
                 H 
                 H 
               
               
                 II-227 
                 NO 2   
                 H 
                 CN 
                 CF 3   
                 H 
               
               
                 II-228 
                 NO 2   
                 H 
                 CF 3   
                 CN 
                 H 
               
               
                 II-229 
                 Br 
                 H 
                 OCF 3   
                 H 
                 Br 
               
               
                 II-230 
                 CH 3   
                 H 
                 Cl 
                 CH 2 CO 2 C 2 H 5   
                 H 
               
               
                 II-231 
                 Cl 
                 CH 3   
                 Cl 
                 H 
                 OCF 2 OCF 3   
               
               
                 II-232 
                 Cl 
                 CH 3   
                 Cl 
                 H 
                 NO 2   
               
               
                 II-233 
                 Cl 
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 II-234 
                 CH 3   
                 Cl 
                 H 
                 H 
                 H 
               
               
                 II-235 
                 CH 3   
                 Cl 
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-236 
                 CH 3   
                 Cl 
                 NO 2   
                 H 
                 H 
               
               
                 II-237 
                 CH 3   
                 Cl 
                 H 
                 H 
                 NO 2   
               
               
                 II-238 
                 Cl 
                 CH 3   
                 NO 2   
                 H 
                 NO 2   
               
               
                 II-239 
                 Cl 
                 CH 3   
                 NO 2   
                 H 
                 H 
               
               
                 II-240 
                 Cl 
                 CH 3   
                 H 
                 H 
                 NO 2   
               
               
                 II-241 
                 Br 
                 H 
                 NO 2   
                 H 
                 CN 
               
               
                 II-242 
                 NO 2   
                 Cl 
                 CF 3   
                 H 
                 NO 2   
               
               
                 II-243 
                 NO 2   
                 H 
                 Cl 
                 Cl 
                 H 
               
               
                 II-244 
                 NO 2   
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                 II-245 
                 Cl 
                 H 
                 NO 2   
                 Cl 
                 H 
               
               
                 II-246 
                 Cl 
                 H 
                 H 
                 Cl 
                 NO 2   
               
               
                 II-247 
                 Cl 
                 Cl 
                 NO 2   
                 H 
                 H 
               
               
                 II-248 
                 Cl 
                 Cl 
                 H 
                 H 
                 NO 2   
               
               
                 II-249 
                 NO 2   
                 Cl 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-250 
                 Cl 
                 H 
                 NO 2   
                 Cl 
                 NO 2   
               
               
                 II-251 
                 Cl 
                 H 
                 Cl 
                 Cl 
                 NO 2   
               
               
                 II-252 
                 Cl 
                 Cl 
                 Cl 
                 NO 2   
                 H 
               
               
                 II-253 
                 Cl 
                 Cl 
                 Cl 
                 H 
                 NO 2   
               
               
                 II-254 
                 Cl 
                 Cl 
                 CN 
                 Cl 
                 CN 
               
               
                 II-255 
                 Cl 
                 H 
                 OCF 2 OCF 3   
                 Cl 
                 H 
               
               
                 II-256 
                 Br 
                 H 
                 NO 2   
                 H 
                 Br 
               
               
                 II-257 
                 F 
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                 II-258 
                 Cl 
                 H 
                 NO 2   
                 H 
                 SCN 
               
               
                 II-259 
                 Br 
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                 II-260 
                 Cl 
                 H 
                 NO 2   
                 H 
                 OCH 3   
               
               
                 II-261 
                 Cl 
                 H 
                 NO 2   
                 H 
                 SCH 3   
               
               
                 II-262 
                 Cl 
                 H 
                 NO 2   
                 H 
                 NHCH 3   
               
               
                 II-263 
                 Cl 
                 H 
                 NO 2   
                 H 
                 SO 2 CH 3   
               
               
                 II-264 
                 Cl 
                 H 
                 SO 2 CH 3   
                 H 
                 H 
               
               
                 II-265 
                 Cl 
                 H 
                 SO 2 CH 3   
                 H 
                 Cl 
               
               
                 II-266 
                 Cl 
                 H 
                 CH 3   
                 H 
                 Cl 
               
               
                 II-267 
                 Cl 
                 H 
                 CO 2 CH 3   
                 H 
                 Cl 
               
               
                 II-268 
                 Cl 
                 H 
                 CONHCH 3   
                 H 
                 Cl 
               
               
                 II-269 
                 Cl 
                 H 
                 CON(CH 3 ) 2   
                 H 
                 Cl 
               
               
                 II-270 
                 Cl 
                 H 
                 CF(CF 3 ) 2   
                 H 
                 Cl 
               
               
                 II-271 
                 Cl 
                 H 
                 CF(CF 3 ) 2   
                 H 
                 Br 
               
               
                 II-272 
                 F 
                 H 
                 CF(CF 3 ) 2   
                 H 
                 Br 
               
               
                 II-273 
                 F 
                 H 
                 CF(CF 3 ) 2   
                 H 
                 Cl 
               
               
                 II-274 
                 Cl 
                 CN 
                 Cl 
                 Cl 
                 CN 
               
               
                 II-275 
                 F 
                 F 
                 CN 
                 F 
                 CN 
               
               
                 II-276 
                 SO 2 NH 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 II-277 
                 H 
                 SO 2 NH 2   
                 H 
                 H 
                 H 
               
               
                 II-278 
                 H 
                 H 
                 SO 2 NH 2   
                 H 
                 H 
               
               
                   
               
             
          
         
       
     
     Table 128: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-279-II-556. 
     Table 129: in general formula II-A, W=H, R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-557-II-834. 
     Table 130: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-835-II-1112. 
     Table 131: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-1113-II-1390. 
     Table 132: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-1391-II-1668. 
     Table 133: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-1669-II-1946. 
     Table 134: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-1947-II-2224. 
     Table 135: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-2225-II-2502. 
     Table 136: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-2503-II-2780. 
     Table 137: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-2781-II-3058. 
     Table 138: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-3059-II-3336. 
     Table 139: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-3337-II-3614. 
     Table 140: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-3615-II-3892. 
     Table 141: in general formula II-A, W=H, R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-3893-II-4170. 
     Table 142: in general formula II-A, W=H, R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-4171-II-4448. 
     Table 143: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-4449-II-4726. 
     Table 144: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-4727-II-5004. 
     Table 145: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-5005-II-5282. 
     Table 146: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-5283-II-5560. 
     Table 147: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-5561-II-5838. 
     Table 148: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-5839-II-6116. 
     Table 149: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-6117-II-6394. 
     Table 150: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-6395-II-6672. 
     Table 151: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-6673-II-6950. 
     Table 152: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-6951-II-7228. 
     Table 153: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-7229-II-7506. 
     Table 154: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-7507-II-7784. 
     Table 155: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-7785-II-8062. 
     Table 156: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-8063-II-8340. 
     Table 157: in general formula II-A, W=CH 3 , R 1 =CH 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-8341-II-8618. 
     Table 158: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-8619-II-8896. 
     Table 159: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-8897-II-9174. 
     Table 160: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-9175-II-9452. 
     Table 161: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-9453-II-9730. 
     Table 162: in general formula II-A, W=H, R 1 =CF 3 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-9731-II-10008. 
     Table 163: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-10009-II-10286. 
     Table 164: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-10287-II-10564. 
     Table 165: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-10565-II-10842. 
     Table 166: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-10843-II-11120. 
     Table 167: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-11121-II-11398. 
     Table 168: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-11399-II-11676. 
     Table 169: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-11677-II-11954. 
     Table 170: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-11955-II-12232. 
     Table 171: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-12233-II-12510. 
     Table 172: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-12511-II-12788. 
     Table 173: in general formula II-A, W=H, R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-12789-II-13066. 
     Table 174: in general formula II-A, W=H, R 1 =CF 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-13067-II-13344. 
     Table 175: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-13345-II-13622. 
     Table 176: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-13623-II-13900. 
     Table 177: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-13901-II-14178. 
     Table 178: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =R 5b =Cl, R 3 =R 4 =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-14179-II-14456. 
     Table 179: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-14457-II-14734. 
     Table 180: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-14735-II-15012. 
     Table 181: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-15013-II-15290. 
     Table 182: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =R 4 =H, R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-15291-II-15568. 
     Table 183: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-15569-II-15846. 
     Table 184: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =R 5b =H, R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-15847-II-16124. 
     Table 185: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-16125-II-16402. 
     Table 186: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-16403-II-16680. 
     Table 187: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-16681-II-16958. 
     Table 188: in general formula II-A, W=CH 3 , R 1 =CF 3 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =Br, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-16959-II-17236. 
     Table 189: in general formula II-A, W=CH 3 , R 1 =CHF 2 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-17237-II-17514. 
     Table 190: in general formula II-A, W=CH 3 , R 1 =C 2 H 5 , R 2 =Cl, R 3 =H, R 4 =CH 3 , R 5b =OCH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 127 and corresponding to II-1-II-278 in table 127 in turn, the representative compounds are coded as II-17515-II-17792. 
     
       
                 
         
             
             
         
      
     
     In general formula II-B, R 1 =CH 3 , R 2 =Cl, R 7 =R 8 =R 10 =R 11 =H, R 9 =CF 3 , the substituent R 12  refers to Table 191, the representative compounds are coded as II-17793-II-17932. 
     
       
         
               
               
               
             
           
               
                   
                 TABLE 191 
               
               
                   
                   
               
               
                   
                 No. 
                 R 12   
               
               
                   
                   
               
             
             
               
                   
                 II-17793 
                 S-i-C 3 H 7   
               
               
                   
                 II-17794 
                 OH 
               
               
                   
                 II-17795 
                 —C(═O)H 
               
               
                   
                 II-17796 
                 CBr 3   
               
               
                   
                 II-17797 
                 CH 3   
               
               
                   
                 II-17798 
                 C 2 H 5   
               
               
                   
                 II-17799 
                 n-C 3 H 7   
               
               
                   
                 II-17800 
                 i-C 3 H 7   
               
               
                   
                 II-17801 
                 n-C 4 H 9   
               
               
                   
                 II-17802 
                 i-C 4 H 9   
               
               
                   
                 II-17803 
                 t-C 4 H 9   
               
               
                   
                 II-17804 
                 CI 3   
               
               
                   
                 II-17805 
                 CH 2 Br 
               
               
                   
                 II-17806 
                 CHF 2   
               
               
                   
                 II-17807 
                 CHBr 2   
               
               
                   
                 II-17808 
                 CF 3   
               
               
                   
                 II-17809 
                 CH 2 Cl 
               
               
                   
                 II-17810 
                 CHCl 2   
               
               
                   
                 II-17811 
                 CCl 3   
               
               
                   
                 II-17812 
                 CH 2 F 
               
               
                   
                 II-17813 
                 OCH 3   
               
               
                   
                 II-17814 
                 OC 2 H 5   
               
               
                   
                 II-17815 
                 OCH(CH 3 ) 2   
               
               
                   
                 II-17816 
                 OC(CH 3 ) 3   
               
               
                   
                 II-17817 
                 OCF 3   
               
               
                   
                 II-17818 
                 OCH 2 CF 3   
               
               
                   
                 II-17819 
                 OCH 2 F 
               
               
                   
                 II-17820 
                 OCHF 2   
               
               
                   
                 II-17821 
                 SCH 3   
               
               
                   
                 II-17822 
                 SC 2 H 5   
               
               
                   
                 II-17823 
                 SCH 2 CH═CH 2   
               
               
                   
                 II-17824 
                 CH═CH 2   
               
               
                   
                 II-17825 
                 CH 2 CH═CH 2   
               
               
                   
                 II-17826 
                 CH 2 CH═CCl 2   
               
               
                   
                 II-17827 
                 C≡CH 
               
               
                   
                 II-17828 
                 CH 2 C≡CH 
               
               
                   
                 II-17829 
                 CH 2 C≡C—I 
               
               
                   
                 II-17830 
                 CH 2 OCH 3   
               
               
                   
                 II-17831 
                 CH 2 OCH 2 CH 3   
               
               
                   
                 II-17832 
                 CH 2 CH 2 OCH 3   
               
               
                   
                 II-17833 
                 CH 2 CH 2 OCH 2 CH 3   
               
               
                   
                 II-17834 
                 CH 2 OCH 2 Cl 
               
               
                   
                 II-17835 
                 CH 2 OCH 2 CH 2 Cl 
               
               
                   
                 II-17836 
                 CH 2 CH 2 OCH 2 Cl 
               
               
                   
                 II-17837 
                 CH 2 SCH 3   
               
               
                   
                 II-17838 
                 CH 2 SCH 2 CH 3   
               
               
                   
                 II-17839 
                 CH 2 CH 2 SCH 3   
               
               
                   
                 II-17840 
                 CH 2 CH 2 SCH 2 CH 3   
               
               
                   
                 II-17841 
                 CH 2 SCH 2 Cl 
               
               
                   
                 II-17842 
                 CH 2 SCH 2 CH 2 Cl 
               
               
                   
                 II-17843 
                 CH 2 CH 2 SCH 2 Cl 
               
               
                   
                 II-17844 
                 SOCH 3   
               
               
                   
                 II-17845 
                 SOC 2 H 5   
               
               
                   
                 II-17846 
                 SOCF 3   
               
               
                   
                 II-17847 
                 SOCH 2 CF 3   
               
               
                   
                 II-17848 
                 SO 2 CH 3   
               
               
                   
                 II-17849 
                 SO 2 C 2 H 5   
               
               
                   
                 II-17850 
                 SO 2 CF 3   
               
               
                   
                 II-17851 
                 SO 2 CH 2 CF 3   
               
               
                   
                 II-17852 
                 SO 2 NHCOCH 3   
               
               
                   
                 II-17853 
                 SO 2 NHCH 3   
               
               
                   
                 II-17854 
                 SO 2 N(CH 3 ) 3   
               
               
                   
                 II-17855 
                 CONHSO 2 CH 3   
               
               
                   
                 II-17856 
                 COCH 3   
               
               
                   
                 II-17857 
                 COC 2 H 5   
               
               
                   
                 II-17858 
                 CO—n-C 3 H 7   
               
               
                   
                 II-17859 
                 CO—i-C 3 H 7   
               
               
                   
                 II-17860 
                 CO—n-C 4 H 9   
               
               
                   
                 II-17861 
                 CO—i-C 4 H 9   
               
               
                   
                 II-17862 
                 CO—t-C 4 H 9   
               
               
                   
                 II-17863 
                 COCF 3   
               
               
                   
                 II-17864 
                 COCH 2 Cl 
               
               
                   
                 II-17865 
                 COOCH 3   
               
               
                   
                 II-17866 
                 COOC 2 H 5   
               
               
                   
                 II-17867 
                 COO—n-C 3 H 7   
               
               
                   
                 II-17868 
                 COO—t-C 4 H 9   
               
               
                   
                 II-17869 
                 COOCF 3   
               
               
                   
                 II-17870 
                 COOCH 2 CH 2 Cl 
               
               
                   
                 II-17871 
                 COOCH 2 CF 3   
               
               
                   
                 II-17872 
                 CH 2 COOCH 3   
               
               
                   
                 II-17873 
                 CH 2 COOC 2 H 5   
               
               
                   
                 II-17874 
                 CH 2 COCH 3   
               
               
                   
                 II-17875 
                 CH 2 COC 2 H 5   
               
               
                   
                 II-17876 
                 CONHCH 3   
               
               
                   
                 II-17877 
                 CONHC 2 H 5   
               
               
                   
                 II-17878 
                 CONH—t-C 4 H 9   
               
               
                   
                 II-17879 
                 CON(CH 3 ) 2   
               
               
                   
                 II-17880 
                 CON(C 2 H 5 ) 2   
               
               
                   
                 II-17881 
                 COOCH 2 CH═CH 2   
               
               
                   
                 II-17882 
                 COOCH 2 C≡CH 
               
               
                   
                 II-17883 
                 COOCH 2 OCH 3   
               
               
                   
                 II-17884 
                 COOCH 2 CH 2 OCH 3   
               
               
                   
                 II-17885 
                 SNHCH 3   
               
               
                   
                 II-17886 
                 SNHC 2 H 5   
               
               
                   
                 II-17887 
                 SN(CH 3 ) 2   
               
               
                   
                 II-17888 
                 SN(C 2 H 5 ) 2   
               
               
                   
                   
               
               
                   
                 II-17889 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17890 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17891 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17892 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17893 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17894 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17895 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17896 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17897 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17898 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17899 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17900 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17901 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17902 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17903 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17904 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17905 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17906 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17907 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17908 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17909 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17910 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17911 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17912 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17913 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17914 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17915 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17916 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17917 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17918 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17919 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17920 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17921 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17922 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17923 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17924 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17925 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17926 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17927 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17928 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17929 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17930 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17931 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 II-17932 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
             
          
         
       
     
     Table 192: in general formula II-B, R 1 =C 2 H 5 , R 2 =Cl, R 7 =R 8 =R 10 =R 11 =H, R 9 =CF 3 , the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-17933-II-18072. 
     Table 193: in general formula II-B, R 1 =CH 3 , R 2 =R 9 =Cl, R 7 =R 8 =R 10 =R 11 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18073-II-18212. 
     Table 194: in general formula II-B, R 1 =C 2 H 5 , R 2 =R 9 =Cl, R 7 =R 8 =R 10 =R 1 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18213-II-18352. 
     Table 195: in general formula II-B, R 1 =CH 3 , R 2 =R 7 =R 9 =Cl, R 8 =R 10 =R 11 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18353-II-18492. 
     Table 196: in general formula II-B, R 1 =C 2 H 5 , R 2 =R 7 =R 9 =Cl, R 8 =R 10 =R 11 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18493-II-18632. 
     Table 197: in general formula II-B, R 1 =CH 3 , R 2 =R 7 =R 11 =Cl, R 8 =R 10 =H, R 9 =NO 2 , the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18633-II-18772. 
     Table 198: in general formula II-B, R 1 =C 2 H 5 , R 2 =R 7 =R 1 =Cl, R 8 =R 10 =H, R 9 =NO 2 , the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18773-II-18912. 
     Table 199: in general formula II-B, R 1 =CHF 2 , R 2 =R 9 =Cl, R 7 =R 8 =R 10 =R 11 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-18913-II-19052. 
     Table 200: in general formula II-B, R 1 =CHF 2 , R 2 =Cl, R 7 =R 8 =R 10 =R 11 =H, R 9 =CF 3 , the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-19053-II-19192. 
     Table 201: in general formula II-B, R 1 =CHF 2 , R 2 =R 7 =R 9 =Cl, R 8 =R 10 =R 11 =H, the substituent R 12  are consistent with those in Table 191 and corresponding to II-17793-II-17932 in table 191 in turn, the representative compounds are coded as II-19193-II-19332. 
     The salts of some compounds having a structure as represented by formula II of the present invention are listed in Table 202, but without being restricted thereby. 
     
       
         
               
             
               
               
             
           
               
                 TABLE 202 
               
             
             
               
                   
               
               
                 the salts of some compounds 
               
             
          
           
               
                 No. 
                 structure 
               
               
                   
               
               
                 II-19333 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19334 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19335 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19336 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19337 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19338 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19339 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19340 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19341 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19342 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19343 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19344 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19345 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19346 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19347 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19348 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19349 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19350 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19351 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19352 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19353 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19354 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19355 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19356 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19357 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19358 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19359 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19360 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19361 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19362 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19363 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19364 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19365 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19366 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19367 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19368 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19369 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19370 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19371 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19372 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19373 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19374 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19375 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19376 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19377 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19378 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19379 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19380 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19381 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19382 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19383 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19384 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19385 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19386 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19387 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19388 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19389 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19390 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19391 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19392 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19393 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19394 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19395 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19396 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19397 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19398 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19399 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19400 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19401 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19402 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19403 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19404 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19405 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19406 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19407 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19408 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19409 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19410 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19411 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19412 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19413 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19414 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19415 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19416 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19417 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19418 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19419 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19420 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19421 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19422 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19423 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19424 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19425 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19426 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19427 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19428 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19429 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19430 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19431 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19432 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19433 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19434 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19435 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 II-19436 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     In the general formula III, part of preferred substituents of R 1 , R 2 , W, R 3  and R 4  are separately listed in table 203 to table 206, but without being restricted thereby. The definitions of other substituents are defined as above. 
     
       
         
               
             
           
               
                 TABLE 203 
               
               
                   
               
               
                 R 1  substituents 
               
               
                 R 1   
               
               
                   
               
             
             
               
                 H 
               
               
                 F 
               
               
                 Cl 
               
               
                 Br 
               
               
                 I 
               
               
                 CH 3   
               
               
                 C 2 H 5   
               
               
                 n-C 3 H 7   
               
               
                 i-C 3 H 7   
               
               
                 n-C 4 H 9   
               
               
                 i-C 4 H 9   
               
               
                 t-C 4 H 9   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CH 2 Cl 
               
               
                 CHCl 2   
               
               
                 CH 2 CH═CH 2   
               
               
                 CCl 3   
               
               
                 CHF 2   
               
               
                 CHBr 2   
               
               
                 CF 3   
               
               
                 CH(CH 3 )F 
               
               
                 CH(CH 3 )Cl 
               
               
                 CH(CH 3 )Br 
               
               
                 C(CH 3 ) 2 F 
               
               
                 OCH 3   
               
               
                 OC 2 H 5   
               
               
                 OCF 3   
               
               
                 OCH 2 CH═CH 2   
               
               
                 OCH 2 CH═CHCl 
               
               
                 OCH 2 C≡CH 
               
               
                 OCH 2 C≡C—I 
               
               
                 OCH 2 C≡CCH 3   
               
               
                 OSO 2 CH 3   
               
               
                 CH 2 C≡CH 
               
               
                 SCH 3   
               
               
                 SOCH 3   
               
               
                 SO 2 CH 3   
               
               
                 COOH 
               
               
                 COOCH 3   
               
               
                 COOC 2 H 5   
               
               
                 CONH 2   
               
               
                 CONHCH 3   
               
               
                 CONHCN 
               
               
                 CONHCH 2 CN 
               
               
                 CON(CH 3 ) 2   
               
               
                 NH 2   
               
               
                 NHCH 3   
               
               
                 NHC 2 H 5   
               
               
                 N(CH 3 ) 2   
               
               
                 N(C 2 H 5 ) 2   
               
               
                 NHCH 2 CN 
               
               
                 CH 2 OCH 2 Cl 
               
               
                 NHOCH 3   
               
               
                 NHOC 2 H 5   
               
               
                 NHCOCH 3   
               
               
                 NHCOC 2 H 5   
               
               
                 NHCOOCH 3   
               
               
                 NHCOOC 2 H 5   
               
               
                 N(CH 3 )NH 2   
               
               
                 NHN(CH 3 ) 2   
               
               
                 CH 2 OCH 3   
               
               
                 CH 2 OCH 2 CH 3   
               
               
                 CH 2 CH 2 OCH 3   
               
               
                 CH 2 CH 2 OCH 2 CH 3   
               
               
                 CH(CH 3 )SCH 3   
               
               
                 CH(CH 3 )SOCH 3   
               
               
                 CH(CH 3 )SO 2 CH 3   
               
               
                 CH(CH 3 )OH 
               
               
                 CH(CH 3 )OCOCH 3   
               
               
                 CH 2 OCH 2 CH 2 Cl 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 204 
               
             
             
               
                   
               
               
                 R 2  substituents 
               
             
          
           
               
                   
                 R 2   
                 R 2   
                 R 2   
                 R 2   
               
               
                   
                   
               
               
                   
                 H 
                 NO 2   
                 t-C 4 H 9   
                 OC 4 H 9 -i 
               
               
                   
                 F 
                 CH 3   
                 OCH 3   
                 OC 4 H 9 -t 
               
               
                   
                 Cl 
                 C 2 H 5   
                 OC 2 H 5   
                 OCH 2 F 
               
               
                   
                 Br 
                 n-C 3 H 7   
                 OC 3 H 7 -n 
                 OCHF 2   
               
               
                   
                 I 
                 i-C 3 H 7   
                 OC 3 H 7 -i 
                 OCF 3   
               
               
                   
                 CN 
                 n-C 4 H 9   
                 OC 4 H 9 -n 
                 OCH 2 CF 3   
               
               
                   
                   
               
             
          
         
       
     
     
       
         
               
             
           
               
                 TABLE 205 
               
               
                   
               
               
                 W substituents 
               
               
                 W 
               
               
                   
               
             
             
               
                 H 
               
               
                 F 
               
               
                 Cl 
               
               
                 Br 
               
               
                 I 
               
               
                 CH 3   
               
               
                 C 2 H 5   
               
               
                 n-C 3 H 7   
               
               
                 i-C 3 H 7   
               
               
                 n-C 4 H 9   
               
               
                 t-C 4 H 9   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CHCl 2   
               
               
                 CCl 3   
               
               
                 CHF 2   
               
               
                 CHBr 2   
               
               
                 CF 3   
               
               
                 CH(CH 3 )F 
               
               
                 CH(CH 3 )Cl 
               
               
                 CH(CH 3 )Br 
               
               
                 CH(n-C 4 H 9 )F 
               
               
                 C(CH 3 ) 2 F 
               
               
                 OCH 3   
               
               
                 OC 2 H 5   
               
               
                 OC 3 H 7 -n 
               
               
                 OC 3 H 7 -i 
               
               
                 OC 4 H 9 -n 
               
               
                 OC 4 H 9 -i 
               
               
                 OC 4 H 9 -t 
               
               
                 OCF 3   
               
               
                 OCH 2 CF 3   
               
               
                 SCH 3   
               
               
                 SC 2 H 5   
               
               
                 SC 3 H 7 -n 
               
               
                 SC 3 H 7 -i 
               
               
                 SC 4 H 9 -n 
               
               
                 SC 4 H 9 -i 
               
               
                 SC 4 H 9 -t 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
           
               
                 TABLE 206 
               
               
                   
               
               
                 R 3 (R 4 )substituents 
               
               
                   
               
             
             
               
                 R 3 (R 4 ) 
               
               
                   
               
               
                 H 
               
               
                 CH 3   
               
               
                 C 2 H 5   
               
               
                 n-C 3 H 7   
               
               
                 i-C 3 H 7   
               
               
                 n-C 4 H 9   
               
               
                 i-C 4 H 9   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 t-C 4 H 9   
               
               
                 CH═CH 2   
               
               
                 C≡CH 
               
               
                 CH 2 CH═CH 2   
               
               
                 CH 2 C≡CH 
               
               
                 CH 2 CH═CCl 2   
               
               
                 CH 2 C≡C—I 
               
               
                 CH 2 OCH 3   
               
               
                 CH 2 OCH 2 CH 3   
               
               
                 CH 2 CH 2 OCH 3   
               
               
                 CH 2 CH 2 OCH 2 CH 3   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CR 3 R 4   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     The present invention is also explained by the following compounds having a structure as represented by formula III listed in Table 207 to Table 304, but without being restricted thereby. The compounds having a structure as represented by formula III-A, III-B, III-C, III-D, III-E, III-F, III-G and III-H refer to Table 207 to Table 304, R 5a =R 5c =H. 
     In general formula III-A, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  refer to Table 207, the representative compounds are coded as III-1-III-180. 
     
       
         
               
               
               
               
               
               
             
           
               
                 TABLE 207 
               
               
                   
               
               
                 No. 
                 R 7   
                 R 8   
                 R 9   
                 R 10   
                 R 11   
               
               
                   
               
             
             
               
                 III-1 
                 H 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-2 
                 F 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-3 
                 H 
                 F 
                 H 
                 H 
                 H 
               
               
                 III-4 
                 H 
                 H 
                 F 
                 H 
                 H 
               
               
                 III-5 
                 Cl 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-6 
                 H 
                 Cl 
                 H 
                 H 
                 H 
               
               
                 III-7 
                 H 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 III-8 
                 Br 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-9 
                 H 
                 Br 
                 H 
                 H 
                 H 
               
               
                 III-10 
                 H 
                 H 
                 Br 
                 H 
                 H 
               
               
                 III-11 
                 I 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-12 
                 H 
                 I 
                 H 
                 H 
                 H 
               
               
                 III-13 
                 H 
                 H 
                 I 
                 H 
                 H 
               
               
                 III-14 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-15 
                 H 
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-16 
                 H 
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 III-17 
                 OCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-18 
                 H 
                 OCH 3   
                 H 
                 H 
                 H 
               
               
                 III-19 
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                 III-20 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-21 
                 H 
                 CF 3   
                 H 
                 H 
                 H 
               
               
                 III-22 
                 H 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 III-23 
                 OCF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-24 
                 H 
                 OCF 3   
                 H 
                 H 
                 H 
               
               
                 III-25 
                 H 
                 H 
                 OCF 3   
                 H 
                 H 
               
               
                 III-26 
                 NO 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-27 
                 H 
                 NO 2   
                 H 
                 H 
                 H 
               
               
                 III-28 
                 H 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-29 
                 CN 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-30 
                 H 
                 CN 
                 H 
                 H 
                 H 
               
               
                 III-31 
                 H 
                 H 
                 CN 
                 H 
                 H 
               
               
                 III-32 
                 CH(CH 3 ) 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-33 
                 H 
                 CH(CH 3 ) 2   
                 H 
                 H 
                 H 
               
               
                 III-34 
                 H 
                 H 
                 CH(CH 3 ) 2   
                 H 
                 H 
               
               
                 III-35 
                 H 
                 H 
                 t-Bu 
                 H 
                 H 
               
               
                 III-36 
                 SCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-37 
                 H 
                 SCH 3   
                 H 
                 H 
                 H 
               
               
                 III-38 
                 H 
                 H 
                 SCH 3   
                 H 
                 H 
               
               
                 III-39 
                 SCF 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-40 
                 H 
                 SCF 3   
                 H 
                 H 
                 H 
               
               
                 III-41 
                 H 
                 H 
                 SCF 3   
                 H 
                 H 
               
               
                 III-42 
                 COCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-43 
                 H 
                 COCH 3   
                 H 
                 H 
                 H 
               
               
                 III-44 
                 H 
                 H 
                 COCH 3   
                 H 
                 H 
               
               
                 III-45 
                 SOCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-46 
                 H 
                 SOCH 3   
                 H 
                 H 
                 H 
               
               
                 III-47 
                 H 
                 H 
                 SOCH 3   
                 H 
                 H 
               
               
                 III-48 
                 SO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-49 
                 H 
                 SO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-50 
                 H 
                 H 
                 SO 2 CH 3   
                 H 
                 H 
               
               
                 III-51 
                 OCHF 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-52 
                 H 
                 OCHF 2   
                 H 
                 H 
                 H 
               
               
                 III-53 
                 H 
                 H 
                 OCHF 2   
                 H 
                 H 
               
               
                 III-54 
                 CO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-55 
                 H 
                 CO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-56 
                 H 
                 H 
                 CO 2 CH 3   
                 H 
                 H 
               
               
                 III-57 
                 N(CH 3 ) 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-58 
                 H 
                 N(CH 3 ) 2   
                 H 
                 H 
                 H 
               
               
                 III-59 
                 H 
                 H 
                 N(CH 3 ) 2   
                 H 
                 H 
               
               
                 III-60 
                 N(C 2 H 5 ) 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-61 
                 H 
                 N(C 2 H 5 ) 2   
                 H 
                 H 
                 H 
               
               
                 III-62 
                 H 
                 H 
                 N(C 2 H 5 ) 2   
                 H 
                 H 
               
               
                 III-63 
                 NHCOCH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-64 
                 H 
                 NHCOCH 3   
                 H 
                 H 
                 H 
               
               
                 III-65 
                 H 
                 H 
                 NHCOCH 3   
                 H 
                 H 
               
               
                 III-66 
                 NHSO 2 CH 3   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-67 
                 H 
                 NHSO 2 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-68 
                 H 
                 H 
                 NHSO 2 CH 3   
                 H 
                 H 
               
               
                 III-69 
                 OCH 2 CH═CH 2   
                 H 
                 H 
                 H 
                 H 
               
               
                 III-70 
                 H 
                 OCH 2 CH═CH 2   
                 H 
                 H 
                 H 
               
               
                 III-71 
                 H 
                 H 
                 OCH 2 CH═CH 2   
                 H 
                 H 
               
               
                 III-72 
                 OCH 2 C≡CH 
                 H 
                 H 
                 H 
                 H 
               
               
                 III-73 
                 H 
                 OCH 2 C≡CH 
                 H 
                 H 
                 H 
               
               
                 III-74 
                 H 
                 H 
                 OCH 2 C≡CH 
                 H 
                 H 
               
               
                 III-75 
                 F 
                 F 
                 H 
                 H 
                 H 
               
               
                 III-76 
                 F 
                 H 
                 F 
                 H 
                 H 
               
               
                 III-77 
                 F 
                 H 
                 H 
                 F 
                 H 
               
               
                 III-78 
                 F 
                 H 
                 H 
                 H 
                 F 
               
               
                 III-79 
                 H 
                 F 
                 F 
                 H 
                 H 
               
               
                 III-80 
                 H 
                 F 
                 H 
                 F 
                 H 
               
               
                 III-81 
                 Cl 
                 Cl 
                 H 
                 H 
                 H 
               
               
                 III-82 
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 III-83 
                 Cl 
                 H 
                 H 
                 Cl 
                 H 
               
               
                 III-84 
                 Cl 
                 H 
                 H 
                 H 
                 Cl 
               
               
                 III-85 
                 H 
                 Cl 
                 Cl 
                 H 
                 H 
               
               
                 III-86 
                 H 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                 III-87 
                 NO 2   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-88 
                 NO 2   
                 H 
                 H 
                 NO 2   
                 H 
               
               
                 III-89 
                 NO 2   
                 H 
                 H 
                 H 
                 NO 2   
               
               
                 III-90 
                 H 
                 NO 2   
                 H 
                 NO 2   
                 H 
               
               
                 III-91 
                 CN 
                 H 
                 CN 
                 H 
                 H 
               
               
                 III-92 
                 CN 
                 H 
                 H 
                 CN 
                 H 
               
               
                 III-93 
                 CN 
                 H 
                 H 
                 H 
                 CN 
               
               
                 III-94 
                 H 
                 CN 
                 H 
                 CN 
                 H 
               
               
                 III-95 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-96 
                 CH 3   
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 III-97 
                 CH 3   
                 H 
                 H 
                 CH 3   
                 H 
               
               
                 III-98 
                 CH 3   
                 H 
                 H 
                 H 
                 CH 3   
               
               
                 III-99 
                 H 
                 CH 3   
                 CH 3   
                 H 
                 H 
               
               
                 III-100 
                 H 
                 CH 3   
                 H 
                 CH 3   
                 H 
               
               
                 III-101 
                 CF 3   
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 III-102 
                 CF 3   
                 H 
                 H 
                 CF 3   
                 H 
               
               
                 III-103 
                 CF 3   
                 H 
                 H 
                 H 
                 CF 3   
               
               
                 III-104 
                 H 
                 CF 3   
                 H 
                 CF 3   
                 H 
               
               
                 III-105 
                 OCF 3   
                 H 
                 OCF 3   
                 H 
                 H 
               
               
                 III-106 
                 OCF 3   
                 H 
                 H 
                 OCF 3   
                 H 
               
               
                 III-107 
                 OCF 3   
                 H 
                 H 
                 H 
                 OCF 3   
               
               
                 III-108 
                 H 
                 OCF 3   
                 H 
                 OCF 3   
                 H 
               
               
                 III-109 
                 CH 3   
                 Cl 
                 H 
                 H 
                 H 
               
               
                 III-110 
                 CH 3   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 III-111 
                 H 
                 Cl 
                 CH 3   
                 H 
                 H 
               
               
                 III-112 
                 Cl 
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 III-113 
                 CH 3   
                 H 
                 H 
                 Cl 
                 H 
               
               
                 III-114 
                 CH 3   
                 H 
                 H 
                 H 
                 Cl 
               
               
                 III-115 
                 Br 
                 CH 3   
                 H 
                 H 
                 H 
               
               
                 III-116 
                 H 
                 CH 3   
                 Cl 
                 H 
                 H 
               
               
                 III-117 
                 CH 3   
                 NO 2   
                 H 
                 H 
                 H 
               
               
                 III-118 
                 CH 3   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-119 
                 CH 3   
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                 III-120 
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
               
               
                 III-121 
                 Cl 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 III-122 
                 Cl 
                 H 
                 H 
                 CF 3   
                 H 
               
               
                 III-123 
                 Cl 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-124 
                 Cl 
                 H 
                 H 
                 NO 2   
                 H 
               
               
                 III-125 
                 CF 3   
                 H 
                 Br 
                 H 
                 H 
               
               
                 III-126 
                 CF 3   
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-127 
                 H 
                 CF 3   
                 NO 2   
                 H 
                 H 
               
               
                 III-128 
                 H 
                 CF 3   
                 Cl 
                 H 
                 H 
               
               
                 III-129 
                 CF 3   
                 H 
                 CN 
                 H 
                 H 
               
               
                 III-130 
                 Cl 
                 H 
                 CN 
                 H 
                 H 
               
               
                 III-131 
                 NO 2   
                 H 
                 CN 
                 H 
                 H 
               
               
                 III-132 
                 NO 2   
                 H 
                 CH 3   
                 H 
                 H 
               
               
                 III-133 
                 NO 2   
                 H 
                 CF 3   
                 H 
                 H 
               
               
                 III-134 
                 NO 2   
                 H 
                 Cl 
                 H 
                 H 
               
               
                 III-135 
                 NO 2   
                 H 
                 H 
                 Cl 
                 H 
               
               
                 III-136 
                 H 
                 NO 2   
                 CH 3   
                 H 
                 H 
               
               
                 III-137 
                 H 
                 NO 2   
                 Cl 
                 H 
                 H 
               
               
                 III-138 
                 CN 
                 F 
                 H 
                 H 
                 H 
               
               
                 III-139 
                 CN 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                 III-140 
                 CN 
                 H 
                 Cl 
                 H 
                 H 
               
               
                 III-141 
                 CN 
                 H 
                 H 
                 CH 3   
                 H 
               
               
                 III-142 
                 Cl 
                 Cl 
                 Cl 
                 H 
                 H 
               
               
                 III-143 
                 Cl 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                 III-144 
                 Cl 
                 H 
                 Cl 
                 Cl 
                 H 
               
               
                 III-145 
                 Cl 
                 H 
                 Cl 
                 H 
                 Cl 
               
               
                 III-146 
                 H 
                 Cl 
                 Cl 
                 Cl 
                 H 
               
               
                 III-147 
                 CH 3   
                 H 
                 CH 3   
                 H 
                 CH 3   
               
               
                 III-148 
                 OCH 3   
                 H 
                 OCH 3   
                 H 
                 OCH 3   
               
               
                 III-149 
                 Cl 
                 Cl 
                 Br 
                 H 
                 H 
               
               
                 III-150 
                 F 
                 H 
                 F 
                 H 
                 Cl 
               
               
                 III-151 
                 CH 3   
                 H 
                 Br 
                 H 
                 Br 
               
               
                 III-152 
                 CF 3   
                 H 
                 Cl 
                 H 
                 Cl 
               
               
                 III-153 
                 CF 3   
                 H 
                 Br 
                 H 
                 Br 
               
               
                 III-154 
                 F 
                 H 
                 Cl 
                 H 
                 Br 
               
               
                 III-155 
                 Cl 
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                 III-156 
                 Br 
                 H 
                 NO 2   
                 H 
                 Br 
               
               
                 III-157 
                 Cl 
                 H 
                 CN 
                 H 
                 Cl 
               
               
                 III-158 
                 Cl 
                 H 
                 CF 3   
                 H 
                 Cl 
               
               
                 III-159 
                 Br 
                 H 
                 CF 3   
                 H 
                 Br 
               
               
                 III-160 
                 Cl 
                 CH 3   
                 H 
                 H 
                 Cl 
               
               
                 III-161 
                 Cl 
                 H 
                 CONH 2   
                 H 
                 Cl 
               
               
                 III-162 
                 Cl 
                 H 
                 CO 2 CH 3   
                 H 
                 Cl 
               
               
                 III-163 
                 Cl 
                 H 
                 NHCOCH 3   
                 H 
                 Cl 
               
               
                 III-164 
                 Cl 
                 H 
                 OCF 3   
                 H 
                 Cl 
               
               
                 III-165 
                 Br 
                 H 
                 F 
                 H 
                 Br 
               
               
                 III-166 
                 Br 
                 H 
                 CH 3   
                 H 
                 Br 
               
               
                 III-167 
                 Cl 
                 H 
                 COCH 3   
                 H 
                 Cl 
               
               
                 III-168 
                 Cl 
                 H 
                 NO 2   
                 Cl 
                 H 
               
               
                 III-169 
                 F 
                 H 
                 F 
                 H 
                 Cl 
               
               
                 III-170 
                 Cl 
                 H 
                 CF 3   
                 H 
                 Br 
               
               
                 III-171 
                 CH 3   
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                 III-172 
                 CH 3   
                 H 
                 NO 2   
                 H 
                 Br 
               
               
                 III-173 
                 CH 3   
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                 III-174 
                 CH 3   
                 H 
                 Br 
                 H 
                 NO 2   
               
               
                 III-175 
                 NO 2   
                 H 
                 CF 3   
                 H 
                 Cl 
               
               
                 III-176 
                 NO 2   
                 H 
                 CF 3   
                 H 
                 Br 
               
               
                 III-177 
                 F 
                 H 
                 Br 
                 H 
                 Br 
               
               
                 III-178 
                 CN 
                 H 
                 Cl 
                 H 
                 Cl 
               
               
                 III-179 
                 CN 
                 H 
                 Br 
                 H 
                 Br 
               
               
                 III-180 
                 F 
                 H 
                 CN 
                 H 
                 H 
               
               
                   
               
             
          
         
       
     
     Table 208: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-181-III-360. 
     Table 209: A=NH, R 1 =CF 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the s substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-361-III-540. 
     Table 210: A=NH, R 1 =CHF 2 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-541-III-720. 
     Table 211: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-721-III-900. 
     Table 212: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-901-III-1080. 
     Table 213: A=NH, R 1 =CF 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1081-III-1260. 
     Table 214: A=NH, R 1 =CHF 2 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1261-III-1440. 
     Table 215: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1441-III-1620. 
     Table 216: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1621-III-1800. 
     Table 217: A=NH, R 1 =CF 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1801-III-1980. 
     Table 218: A=NH, R 1 =CHF 2 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-1981-III-2160. 
     Table 219: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-2161-III-2340. 
     Table 220: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-2341-III-2520. 
     Table 221: A=NH, R 1 =Cl, R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-2521-III-2700. 
     Table 222: A=NH, R 1 =CHF 2 , R 2 =Cl, W=CH 3 , R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-2701-III-2880. 
     Table 223: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 4 =R 5b =H, R 3 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-2881-III-3060. 
     Table 224: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 4 =R 5b =H, R 3 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3061-III-3240. 
     Table 225: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 4 =H, R 3 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3241-III-3420. 
     Table 226: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 4 =H, R 3 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3421-III-3600. 
     Table 227: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 5b =H, R 3 =R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3601-III-3780. 
     Table 228: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 5b =H, R 3 =R 4 =CH 3 , the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3781-III-3960. 
     Table 229: A=NH, R 1 =CH 3 , R 2 =Cl, W=H, R 3 =R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-3961-III-4140. 
     Table 230: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=H, R 3 =R 4 =CH 3 , R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-4141-III-4320. 
     Table 231: A=O, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-4321-III-4500. 
     Table 232: A=O, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-4501-III-4680. 
     Table 233: A=O, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-4681-III-4860. 
     Table 234: A=O, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-4861-III-5040. 
     Table 235: A=S, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-5041-III-5220. 
     Table 236: A=S, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-5221-III-5400. 
     Table 237: A=S, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-5401-III-5580. 
     Table 238: A=S, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 9 , R 10  and R 11  are consistent with those in Table 207 and corresponding to III-1-III-180 in table 207 in turn, the representative compounds are coded as III-5581-III-5760. 
     In general formula III-B, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  refer to Table 239, the representative compounds are coded as III-5761-III-5802. 
     
       
         
               
               
               
               
               
               
             
           
               
                   
                 TABLE 239 
               
               
                   
                   
               
               
                   
                 No. 
                 R 8   
                 R 9   
                 R 10   
                 R 11   
               
               
                   
                   
               
             
             
               
                   
                 III-5761 
                 H 
                 H 
                 H 
                 H 
               
               
                   
                 III-5762 
                 H 
                 H 
                 H 
                 F 
               
               
                   
                 III-5763 
                 H 
                 H 
                 H 
                 Cl 
               
               
                   
                 III-5764 
                 H 
                 H 
                 H 
                 Br 
               
               
                   
                 III-5765 
                 H 
                 H 
                 Cl 
                 H 
               
               
                   
                 III-5766 
                 H 
                 Cl 
                 H 
                 H 
               
               
                   
                 III-5767 
                 H 
                 Br 
                 H 
                 H 
               
               
                   
                 III-5768 
                 Cl 
                 H 
                 H 
                 H 
               
               
                   
                 III-5769 
                 H 
                 H 
                 H 
                 NO 2   
               
               
                   
                 III-5770 
                 H 
                 H 
                 NO 2   
                 H 
               
               
                   
                 III-5771 
                 H 
                 NO 2   
                 H 
                 H 
               
               
                   
                 III-5772 
                 H 
                 CN 
                 H 
                 H 
               
               
                   
                 III-5773 
                 H 
                 OCF 3   
                 H 
                 H 
               
               
                   
                 III-5774 
                 H 
                 H 
                 H 
                 CH 3   
               
               
                   
                 III-5775 
                 H 
                 H 
                 CH 3   
                 H 
               
               
                   
                 III-5776 
                 H 
                 CH 3   
                 H 
                 H 
               
               
                   
                 III-5777 
                 CH 3   
                 H 
                 H 
                 H 
               
               
                   
                 III-5778 
                 H 
                 H 
                 H 
                 CF 3   
               
               
                   
                 III-5779 
                 H 
                 H 
                 CF 3   
                 H 
               
               
                   
                 III-5780 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                   
                 III-5781 
                 H 
                 H 
                 H 
                 OCH 3   
               
               
                   
                 III-5782 
                 H 
                 H 
                 OCH 3   
                 H 
               
               
                   
                 III-5783 
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                   
                 III-5784 
                 OCH 3   
                 H 
                 H 
                 H 
               
               
                   
                 III-5785 
                 H 
                 Cl 
                 H 
                 Cl 
               
               
                   
                 III-5786 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                   
                 III-5787 
                 H 
                 NO 2   
                 H 
                 Cl 
               
               
                   
                 III-5788 
                 H 
                 CN 
                 H 
                 Cl 
               
               
                   
                 III-5789 
                 H 
                 CF 3   
                 H 
                 Cl 
               
               
                   
                 III-5790 
                 H 
                 NO 2   
                 H 
                 Br 
               
               
                   
                 III-5791 
                 H 
                 H 
                 Cl 
                 NO 2   
               
               
                   
                 III-5792 
                 H 
                 Cl 
                 H 
                 NO 2   
               
               
                   
                 III-5793 
                 H 
                 CN 
                 H 
                 CH 3   
               
               
                   
                 III-5794 
                 H 
                 Br 
                 CH 3   
                 H 
               
               
                   
                 III-5795 
                 H 
                 NO 2   
                 CH 3   
                 H 
               
               
                   
                 III-5796 
                 CH 3   
                 H 
                 CH 3   
                 H 
               
               
                   
                 III-5797 
                 H 
                 Cl 
                 H 
                 CF 3   
               
               
                   
                 III-5798 
                 Cl 
                 H 
                 H 
                 CF 3   
               
               
                   
                 III-5799 
                 CH 3   
                 Cl 
                 CH 3   
                 Cl 
               
               
                   
                 III-5800 
                 Cl 
                 Cl 
                 H 
                 Cl 
               
               
                   
                 III-5801 
                 Cl 
                 CF 3   
                 H 
                 Br 
               
               
                   
                 III-5802 
                 H 
                 Br 
                 CH 3   
                 Br 
               
               
                   
                   
               
             
          
         
       
     
     Table 240: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-5803-III-5844. 
     Table 241: A=NH, R 1 =CF 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-5845-III-5886. 
     Table 242: A=NH, R 1 =CHF 2 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-5887-III-5928. 
     Table 243: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-5929-III-5970. 
     Table 244: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-5971-III-6012. 
     Table 245: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6013-III-6054. 
     Table 246: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6055-III-6096. 
     Table 247: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6097-III-6138. 
     Table 248: A=O, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6139-III-6180. 
     Table 249: A=S, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6181-III-6222. 
     Table 250: A=S, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 239 and corresponding to III-5761-III-5802 in table 239 in turn, the representative compounds are coded as III-6223-III-6264. 
     In general formula III-C, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 9 , R 10  and R 11  refer to Table 251, the representative compounds are coded as III-6265-III-6282. 
     
       
         
               
               
               
               
               
               
             
           
               
                   
                 TABLE 251 
               
               
                   
                   
               
               
                   
                 No. 
                 R 7   
                 R 9   
                 R 10   
                 R 11   
               
               
                   
                   
               
             
             
               
                   
                 III-6265 
                 H 
                 H 
                 H 
                 H 
               
               
                   
                 III-6266 
                 Cl 
                 H 
                 H 
                 H 
               
               
                   
                 III-6267 
                 OCH 3   
                 H 
                 H 
                 H 
               
               
                   
                 III-6268 
                 OCH 2 CF 3   
                 H 
                 H 
                 H 
               
               
                   
                 III-6269 
                 H 
                 H 
                 H 
                 CH 3   
               
               
                   
                 III-6270 
                 H 
                 H 
                 H 
                 CF 3   
               
               
                   
                 III-6271 
                 H 
                 Br 
                 H 
                 H 
               
               
                   
                 III-6272 
                 H 
                 CF 3   
                 H 
                 H 
               
               
                   
                 III-6273 
                 H 
                 OCH 3   
                 H 
                 H 
               
               
                   
                 III-6274 
                 Cl 
                 H 
                 Cl 
                 H 
               
               
                   
                 III-6275 
                 Cl 
                 Cl 
                 H 
                 H 
               
               
                   
                 III-6276 
                 H 
                 Cl 
                 Cl 
                 H 
               
               
                   
                 III-6277 
                 Cl 
                 H 
                 H 
                 CH 3   
               
               
                   
                 III-6278 
                 Cl 
                 H 
                 CH 3   
                 H 
               
               
                   
                 III-6279 
                 Cl 
                 CH 3   
                 H 
                 H 
               
               
                   
                 III-6280 
                 Cl 
                 Cl 
                 H 
                 CF 3   
               
               
                   
                 III-6281 
                 H 
                 NHCH 3   
                 Cl 
                 H 
               
               
                   
                 III-6282 
                 H 
                 SO 2 CH 3   
                 Cl 
                 H 
               
               
                   
                   
               
             
          
         
       
     
     Table 252: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 9 , R 10  and R 11  are consistent with those in Table 251 and corresponding to III-6265-III-6282 in table 251 in turn, the representative compounds are coded as III-6283-III-6300. 
     Table 253: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 9 , R 10  and R 11  are consistent with those in Table 251 and corresponding to III-6265-III-6282 in table 251 in turn, the representative compounds are coded as III-6301-III-6318. 
     Table 254: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 9 , R 10  and R 11  are consistent with those in Table 251 and corresponding to III-6265-III-6282 in table 251 in turn, the representative compounds are coded as III-6319-III-6336. 
     Table 255: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 9 , R 10  and R 11  are consistent with those in Table 251 and corresponding to III-6265-III-6282 in table 251 in turn, the representative compounds are coded as III-6337-III-6354. 
     Table 256: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 9 , R 10  and R 11  are consistent with those in Table 251 and corresponding to III-6265-III-6282 in table 251 in turn, the representative compounds are coded as III-6355-III-6372. 
     In general formula III-D, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 10  and R 11  refer to Table 257, the representative compounds are coded as III-6373-III-6380. 
     
       
         
               
               
               
               
               
               
             
           
               
                   
                 TABLE 257 
               
               
                   
                   
               
               
                   
                 No. 
                 R 7   
                 R 8   
                 R 10   
                 R 11   
               
               
                   
                   
               
             
             
               
                   
                 III-6373 
                 H 
                 H 
                 Cl 
                 H 
               
               
                   
                 III-6374 
                 H 
                 H 
                 H 
                 Br 
               
               
                   
                 III-6375 
                 Cl 
                 H 
                 H 
                 Cl 
               
               
                   
                 III-6376 
                 H 
                 H 
                 OCH 3   
                 H 
               
               
                   
                 III-6377 
                 H 
                 OCH 3   
                 OCH 3   
                 H 
               
               
                   
                 III-6378 
                 H 
                 Cl 
                 OCH 3   
                 H 
               
               
                   
                 III-6379 
                 H 
                 Cl 
                 NHCH 3   
                 H 
               
               
                   
                 III-6380 
                 Cl 
                 Cl 
                 Cl 
                 Cl 
               
               
                   
                   
               
             
          
         
       
     
     Table 258: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 10  and R 11  are consistent with those in Table 257 and corresponding to III-6373-III-6380 in table 257 in turn, the representative compounds are coded as III-6381-III-6388. 
     Table 259: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 10  and R 11  are consistent with those in Table 257 and corresponding to III-6373-III-6380 in table 257 in turn, the representative compounds are coded as III-6389-III-6396. 
     Table 260: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 8 , R 10  and R 11  are consistent with those in Table 257 and corresponding to III-6373-III-6380 in table 257 in turn, the representative compounds are coded as III-6397-III-6404. 
     Table 261: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 10  and R 11  are consistent with those in Table 257 and corresponding to III-6373-III-6380 in table 257 in turn, the representative compounds are coded as III-6405-III-6412. 
     Table 262: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 8 , R 10  and R 11  are consistent with those in Table 257 and corresponding to III-6373-III-6380 in table 257 in turn, the representative compounds are coded as III-6413-III-6420. 
     In general formula III-E, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  refer to Table 263, the representative compounds are coded as III-6421-III-6424. 
     
       
         
               
               
               
               
               
             
           
               
                   
                 TABLE 263 
               
               
                   
                   
               
               
                   
                 No. 
                 R 8   
                 R 9   
                 R 10   
               
               
                   
                   
               
             
             
               
                   
                 III-6421 
                 H 
                 H 
                 H 
               
               
                   
                 III-6422 
                 CH 3   
                 H 
                 CH 3   
               
               
                   
                 III-6423 
                 OCH 3   
                 H 
                 OCH 3   
               
               
                   
                 III-6424 
                 CO 2 C 2 H 5   
                 H 
                 CF 3   
               
               
                   
                   
               
             
          
         
       
     
     Table 264: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 263 and corresponding to III-6421-III-6424 in table 263 in turn, the representative compounds are coded as III-6425-III-6428. 
     Table 265: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 263 and corresponding to III-6421-III-6424 in table 263 in turn, the representative compounds are coded as III-6429-III-6432. 
     Table 266: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 263 and corresponding to III-6421-III-6424 in table 263 in turn, the representative compounds are coded as III-6433-III-6436. 
     Table 267: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 263 and corresponding to III-6421-III-6424 in table 263 in turn, the representative compounds are coded as III-6437-III-6440. 
     Table 268: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 9 , R 10  and R 11  are consistent with those in Table 263 and corresponding to III-6421-III-6424 in table 263 in turn, the representative compounds are coded as III-6441-III-6444. 
     In general formula III-F, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 10  and R refer to Table 269, the representative compounds are coded as III-6445-III-6448. 
     
       
         
               
               
               
               
               
             
           
               
                   
                 TABLE 269 
               
               
                   
                   
               
               
                   
                 No. 
                 R 8   
                 R 10   
                 R 11   
               
               
                   
                   
               
             
             
               
                   
                 III-6445 
                 H 
                 H 
                 H 
               
               
                   
                 III-6446 
                 H 
                 Cl 
                 H 
               
               
                   
                 III-6447 
                 CH 3   
                 Cl 
                 H 
               
               
                   
                 III-6448 
                 H 
                 Cl 
                 Cl 
               
               
                   
                   
               
             
          
         
       
     
     Table 270: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 8 , R 10  and R 11  are consistent with those in Table 269 and corresponding to III-6445-III-6448 in table 269 in turn, the representative compounds are coded as III-6449-III-6452. 
     Table 271: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 10  and R 11  are consistent with those in Table 269 and corresponding to III-6445-III-6448 in table 269 in turn, the representative compounds are coded as III-6453-III-6456. 
     Table 272: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 8 , R 10  and R 11  are consistent with those in Table 269 and corresponding to III-6445-III-6448 in table 269 in turn, the representative compounds are coded as III-6457-III-6460. 
     Table 273: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 10  and R 11  are consistent with those in Table 269 and corresponding to III-6445-III-6448 in table 269 in turn, the representative compounds are coded as III-6461-III-6464. 
     Table 274: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 8 , R 10  and R 11  are consistent with those in Table 269 and corresponding to III-6445-III-6448 in table 269 in turn, the representative compounds are coded as III-6465-III-6468. 
     In general formula III-G, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 9  and R 10  refer to Table 275, the representative compounds are coded as III-6469-III-6470. 
     
       
         
               
               
               
               
               
             
           
               
                   
                 TABLE 275 
               
               
                   
                   
               
               
                   
                 No. 
                 R 7   
                 R 9   
                 R 10   
               
               
                   
                   
               
             
             
               
                   
                 III-6469 
                 H 
                 H 
                 H 
               
               
                   
                 III-6470 
                 H 
                 H 
                 Cl 
               
               
                   
                   
               
             
          
         
       
     
     Table 276: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 7 , R 9  and R 10  are consistent with those in Table 275 and corresponding to III-6469-III-6470 in table 275 in turn, the representative compounds are coded as III-6471-III-6472. 
     Table 277: A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 9  and R 10  are consistent with those in Table 275 and corresponding to III-6469-III-6470 in table 275 in turn, the representative compounds are coded as III-6473-III-6474. 
     Table 278: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 7 , R 9  and R 10  are consistent with those in Table 275 and corresponding to III-6469-III-6470 in table 275 in turn, the representative compounds are coded as III-6475-III-6476. 
     Table 279: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 9  and R 10  are consistent with those in Table 275 and corresponding to III-6469-III-6470 in table 275 in turn, the representative compounds are coded as III-6477-III-6478. 
     Table 280: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 7 , R 9  and R 10  are consistent with those in Table 275 and corresponding to III-6469-III-6470 in table 275 in turn, the representative compounds are coded as III-6479-III-6480. 
     In general formula III-H, 
     
       
                 
         
             
             
         
      
     
     A=NH, R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =H, the substituents R 9 , R 10  and R refer to Table 281, the representative compounds are coded as III-6481-III-6482. 
     
       
         
               
               
               
               
               
             
           
               
                   
                 TABLE 281 
               
               
                   
                   
               
               
                   
                 No. 
                 R 9   
                 R 10   
                 R 11   
               
               
                   
                   
               
             
             
               
                   
                 III-6481 
                 H 
                 H 
                 H 
               
               
                   
                 III-6482 
                 Cl 
                 H 
                 H 
               
               
                   
                   
               
             
          
         
       
     
     Table 284: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =H, R 5b =Cl, the substituents R 9 , R 10  and R 11  are consistent with those in Table 281 and corresponding to III-6481-III-6482 in table 281 in turn, the representative compounds are coded as III-6487-III-6488. 
     Table 285: A=NH, R 1 =CH 3 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 9 , R 10  and R 11  are consistent with those in Table 281 and corresponding to III-6481-III-6482 in table 281 in turn, the representative compounds are coded as III-6489-III-6490 
     Table 286: A=NH, R 1 =C 2 H 5 , R 2 =Cl, W=CH 3 , R 3 =R 4 =R 5b =H, the substituents R 9 , R 10  and R 11  are consistent with those in Table 281 and corresponding to III-6481-III-6482 in table 281 in turn, the representative compounds are coded as III-6491-III-6492. 
     In general formula III-A, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 7 =R 8 =R 10 =R 11 =H, R 9 =Cl, the substituents R 12  refer to Table 287, the representative compounds are coded as III-6493-III-6632. 
     
       
         
               
               
               
             
           
               
                   
                 TABLE 287 
               
               
                   
                   
               
               
                   
                 No. 
                 R 12   
               
               
                   
                   
               
             
             
               
                   
                 III-6493 
                 S—i-C 3 H 7   
               
               
                   
                 III-6494 
                 OH 
               
               
                   
                 III-6495 
                 —C(═O)H 
               
               
                   
                 III-6496 
                 CBr 3   
               
               
                   
                 III-6497 
                 CH 3   
               
               
                   
                 III-6498 
                 C 2 H 5   
               
               
                   
                 III-6499 
                 n-C 3 H 7   
               
               
                   
                 III-6500 
                 i-C 3 H 7   
               
               
                   
                 III-6501 
                 n-C 4 H 9   
               
               
                   
                 III-6502 
                 i-C 4 H 9   
               
               
                   
                 III-6503 
                 t-C 4 H 9   
               
               
                   
                 III-6504 
                 CI 3   
               
               
                   
                 III-6505 
                 CH 2 Br 
               
               
                   
                 III-6506 
                 CHF 2   
               
               
                   
                 III-6507 
                 CHBr 2   
               
               
                   
                 III-6508 
                 CF3 
               
               
                   
                 III-6509 
                 CH 2 Cl 
               
               
                   
                 III-6510 
                 CHCl 2   
               
               
                   
                 III-6511 
                 CCl 3   
               
               
                   
                 III-6512 
                 CH 2 F 
               
               
                   
                 III-6513 
                 OCH 3   
               
               
                   
                 III-6514 
                 OC 2 H 5   
               
               
                   
                 III-6515 
                 OCH(CH 3 ) 2   
               
               
                   
                 III-6516 
                 OC(CH 3 ) 3   
               
               
                   
                 III-6517 
                 OCF 3   
               
               
                   
                 III-6518 
                 OCH 2 CF 3   
               
               
                   
                 III-6519 
                 OCH 2 F 
               
               
                   
                 III-6520 
                 OCHF 2   
               
               
                   
                 III-6521 
                 SCH 3   
               
               
                   
                 III-6522 
                 SC 2 H 5   
               
               
                   
                 III-6523 
                 SCH 2 CH═CH 2   
               
               
                   
                 III-6524 
                 CH═CH 2   
               
               
                   
                 III-6525 
                 CH 2 CH═CH 2   
               
               
                   
                 III-6526 
                 CH 2 CH═CCl 2   
               
               
                   
                 III-6527 
                 C≡CH 
               
               
                   
                 III-6528 
                 CH 2 C≡CH 
               
               
                   
                 III-6529 
                 CH 2 C≡C—I 
               
               
                   
                 III-6530 
                 CH 2 OCH 3   
               
               
                   
                 III-6531 
                 CH 2 OCH 2 CH 3   
               
               
                   
                 III-6532 
                 CH 2 CH 2 OCH 3   
               
               
                   
                 III-6533 
                 CH 2 CH 2 OCH 2 CH 3   
               
               
                   
                 III-6534 
                 CH 2 OCH 2 Cl 
               
               
                   
                 III-6535 
                 CH 2 OCH 2 CH 2 Cl 
               
               
                   
                 III-6536 
                 CH 2 CH 2 OCH 2 Cl 
               
               
                   
                 III-6537 
                 CH 2 SCH 3   
               
               
                   
                 III-6538 
                 CH 2 SCH 2 CH 3   
               
               
                   
                 III-6539 
                 CH 2 CH 2 SCH 3   
               
               
                   
                 III-6540 
                 CH 2 CH 2 SCH 2 CH 3   
               
               
                   
                 III-6541 
                 CH 2 SCH 2 Cl 
               
               
                   
                 III-6542 
                 CH 2 SCH 2 CH 2 Cl 
               
               
                   
                 III-6543 
                 CH 2 CH 2 SCH 2 Cl 
               
               
                   
                 III-6544 
                 SOCH 3   
               
               
                   
                 III-6545 
                 SOC 2 H 5   
               
               
                   
                 III-6546 
                 SOCF 3   
               
               
                   
                 III-6547 
                 SOCH 2 CF 3   
               
               
                   
                 III-6548 
                 SO 2 CH 3   
               
               
                   
                 III-6549 
                 SO 2 C 2 H 5   
               
               
                   
                 III-6550 
                 SO 2 CF 3   
               
               
                   
                 III-6551 
                 SO 2 CH 2 CF 3   
               
               
                   
                 III-6552 
                 SO 2 NHCOCH 3   
               
               
                   
                 III-6553 
                 SO 2 NHCH 3   
               
               
                   
                 III-6554 
                 SO 2 N(CH 3 ) 3   
               
               
                   
                 III-6555 
                 CONHSO 2 CH 3   
               
               
                   
                 III-6556 
                 COCH 3   
               
               
                   
                 III-6557 
                 COC 2 H 5   
               
               
                   
                 III-6558 
                 CO—n-C 3 H 7   
               
               
                   
                 III-6559 
                 CO—i-C 3 H 7   
               
               
                   
                 III-6560 
                 CO—n-C 4 H 9   
               
               
                   
                 III-6561 
                 CO—i-C 4 H 9   
               
               
                   
                 III-6562 
                 CO—t-C 4 H 9   
               
               
                   
                 III-6563 
                 COCF 3   
               
               
                   
                 III-6564 
                 COCH 2 Cl 
               
               
                   
                 III-6565 
                 COOCH 3   
               
               
                   
                 III-6566 
                 COOC 2 H 5   
               
               
                   
                 III-6567 
                 COO—n-C 3 H 7   
               
               
                   
                 III-6568 
                 COO—t-C 4 H 9   
               
               
                   
                 III-6569 
                 COOCF 3   
               
               
                   
                 III-6570 
                 COOCH 2 CH 2 Cl 
               
               
                   
                 III-6571 
                 COOCH 2 CF 3   
               
               
                   
                 III-6572 
                 CH 2 COOCH 3   
               
               
                   
                 III-6573 
                 CH 2 COOC 2 H 5   
               
               
                   
                 III-6574 
                 CH 2 COCH 3   
               
               
                   
                 III-6575 
                 CH 2 COC 2 H 5   
               
               
                   
                 III-6576 
                 CONHCH 3   
               
               
                   
                 III-6577 
                 CONHC 2 H 5   
               
               
                   
                 III-6578 
                 CONH—t-C 4 H 9   
               
               
                   
                 III-6579 
                 CON(CH 3 ) 2   
               
               
                   
                 III-6580 
                 CON(C 2 H 5 ) 2   
               
               
                   
                 III-6581 
                 COOCH 2 CH═CH 2   
               
               
                   
                 III-6582 
                 COOCH 2 C≡CH 
               
               
                   
                 III-6583 
                 COOCH 2 OCH 3   
               
               
                   
                 III-6584 
                 COOCH 2 CH 2 OCH 3   
               
               
                   
                 III-6585 
                 SNHCH 3   
               
               
                   
                 III-6586 
                 SNHC 2 H 5   
               
               
                   
                 III-6587 
                 SN(CH 3 ) 2   
               
               
                   
                 III-6588 
                 SN(C 2 H 5 ) 2   
               
               
                   
                   
               
               
                   
                 III-6589 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6590 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6591 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6592 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6593 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6594 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6595 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6596 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6597 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6598 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6599 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6600 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6601 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6602 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6603 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6604 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6605 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6606 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6607 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6608 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6609 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6610 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6611 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6612 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6613 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6614 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6615 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6616 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6617 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6618 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6619 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6620 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6621 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6622 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6623 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6624 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6625 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6626 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6627 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6628 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6629 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6630 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6631 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 III-6632 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
             
          
         
       
     
     Table 288: in general formula III-A, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, R 7 =R 9 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-6633-III-6772. 
     Table 289: in general formula Ill-A, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 7 =R 8 ==R 10 =R 11 =H, R 9 =CF 3 , the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-6773-III-6912. 
     Table 290: in general formula III-B, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, R 9 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-6913-III-7052. 
     Table 291: in general formula III-B, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =R 10 =R 11 =H, R 9 =CF 3 , the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7053-III-7192. 
     Table 292: in general formula III-B, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =R 10 =H, R 9 =CF 3 , R 11 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7193-III-7332. 
     Table 293: in general formula III-B, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =R 10 =H, R 9 =R 11 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7333-III-7472. 
     Table 294: in general formula III-C, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 9 =R 10 =R 11 =H, R 7 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7473-III-7612. 
     Table 295: in general formula III-D, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 7 =R 11 =H, R 8 =R 10 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7613-III-7752. 
     Table 296: in general formula III-E, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 9 =H, R 8 =R 10 =OCH 3 , the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7753-III-7892. 
     Table 297: in general formula III-E, A=NR 12 , R 1 =C 2 H 5 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 9 =H, R 8 =R 10 =CH 3 , the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-7893-III-8032. 
     Table 298: in general formula III-F, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 8 =H, R 10 =CH 3 , R 11 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-8033-III-8172. 
     Table 299: in general formula III-G, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 7 =R 9 =H, R 10 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-8173-III-83122. 
     Table 300: in general formula Ill-H, A=NR 12 , R 1 =CH 3 , R 2 =Cl, W=R 3 =R 4 =R 5b =R 10 =R 11 =H, R 7 =Cl, the substituent R 12  are consistent with those in Table 287 and corresponding to III-6493-III-6632 in table 287 in turn, the representative compounds are coded as III-8313-III-8452. 
     The salts of some compounds having a structure as represented by formula III of the present invention are listed in Table 301, but without being restricted thereby. 
     
       
         
               
             
               
               
             
           
               
                 TABLE 301 
               
             
             
               
                   
               
               
                 the salts of some compounds 
               
             
          
           
               
                 No. 
                 structure 
               
               
                   
               
               
                 III-8453 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8454 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8455 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8456 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8457 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8458 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8459 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8460 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8461 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8462 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8463 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8464 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8465 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8466 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8467 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8468 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8469 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8470 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8471 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8472 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8473 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8474 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8475 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8476 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8477 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8478 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8479 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8480 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8481 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8482 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8483 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8484 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8485 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8486 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8487 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8488 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8489 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8490 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8491 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8492 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8493 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8494 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8495 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 III-8496 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     The compounds represented by general formula PY of the invention can be prepared according to three schemes in which Substituent A can be defined as different substituents, the definitions of each substituent is defined as above: 
     Scheme 1 to prepare the compounds represented by general formula PY: when A=NH, the compounds represented by general formula PY-1 can be prepared according to the following two schemes. 
     Method 1: the compounds represented by general formula PY-1 can be prepared by reaction of intermediates i and ii in the presence of proper base, the preparation methods are shown as follows. 
     
       
                 
         
             
             
         
      
     
     The reaction was carried out in proper solvent and the proper solvent mentioned may be selected from benzene, toluene, xylene, acetone, butanone, methylisobutylketone, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone, DMSO, pyridine, dichloromethane, chloroform, dichloroethane, methyl acetate or ethyl acetate and so on. 
     The reaction above can be carried out in the presence or absence of base, the reaction is promoted in the presence of base. Proper base mentioned may be selected from alkali metal hydride such as sodium hydride; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali metal carbonate such as sodium carbonate or potassium carbonate; organic amine such as pyridine or triethylamine. 
     The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. 
     The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. 
     The detailed operation refers to the methods described in EP0370704, EP0356158, EP0264217, EP0665225, JP10036355 or U.S. Pat. No. 4,985,426. 
     Intermediates I are commercially available, or prepared according to the methods described in JP2000007662, U.S. Pat. No. 4,977,264, U.S. Pat. No. 6,090,815, US20040092402, JP09124613, U.S. Pat. No. 5,468,751, U.S. Pat. No. 4,985,426, U.S. Pat. No. 4,845,097 , Recueil des Travaux Chimiques des Pays - Bas  (1978), 97(11), Pages 288-92, Journal of the American Chemical Society, 79, 1455(1957) or Journal of Chemical Society, p. 3478-3481 (1955). 
     Intermediates ii are commercially available, or prepared according to the methods described in U.S. Pat. No. 4,895,849, JP10036355, EP665225, US20070093498, WO2007046809, U.S. Pat. No. 5,783,522A, WO02083647A1, CN1927860A, WO9404527, US20110054173, WO2011025505, WO2004093800A, WO 2012075917, US20050648509, US2002082454, Organic Syntheses, Coll. Vol. 10, p. 501 (2004); Vol. 75, p. 61 (1998) or Organic Syntheses, Coll. Vol. 10, p. 102 (2004); Vol. 75, p. 53 (1998). 
     Method 2: the compounds represented by general formula iv can be prepared by reaction of intermediates i and iii in proper solvent, then the compounds represented by general formula PY-1 can be prepared by reaction of intermediates iv and v in the presence of proper base, the preparation methods are shown as follows. Wherein, L is a leaving group, selected from halogen, boric acid, methyl methanesulfonate or p-toluenesulfonates. 
     
       
                 
         
             
             
         
      
     
     The reaction was carried out between the intermediates represented by general formula i and iii in proper solvent and the proper solvent mentioned may be selected from benzene, toluene, xylene, acetone, butanone, methylisobutylketone, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone, DMSO, pyridine, dichloromethane, chloroform, dichloroethane, methyl acetate or ethyl acetate and so on. The reaction above can be carried out in the presence or absence of base, the reaction is promoted in the presence of base. Proper base mentioned may be selected from alkali metal hydride such as sodium hydride; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali metal carbonate such as sodium carbonate or potassium carbonate; organic amine such as pyridine or triethylamine. 
     The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. 
     The reaction was carried out between the intermediates represented by general formula iv and v in proper solvent and the proper solvent mentioned may be selected from benzene, toluene, xylene, acetone, butanone, methylisobutylketone, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone, DMSO, pyridine, dichloromethane, chloroform, dichloroethane, methyl acetate or ethyl acetate and so on. The reaction above can be carried out in the presence of base. Proper base mentioned may be selected from alkali metal hydride such as sodium hydride; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali metal carbonate such as sodium carbonate or potassium carbonate; organic amine such as pyridine or triethylamine. 
     The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 200° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. 
     The detailed operation refers to the methods described in JP11049759, EP0370704, EPO 196524 or U.S. Pat. No. 4,895,849. 
     Other materials, such as the compounds represented by general formula iii and v, used to prepare the compounds represented by general formula PY-1, are commercially available. 
     The intermediate represented by general formula ii is one of key intermediate, some compounds are commercially available, or are prepared according to the known method described above, also can be prepared according to the following two schemes in which Substituent X 1  can be defined as different substituents. 
     Method 1: when X 1 =CR 6 , the intermediate ii used to prepare the compounds represented by the general formula I and II (wherein A=NH) can be prepared according to the following two schemes. Relevant intermediates are commercially available, or prepared according to the methods described in U.S. Pat. No. 4,895,849, JP10036355, EP665225, US20070093498, WO2007046809, U.S. Pat. No. 5,783,522A, WO02083647A1, CN1927860A, Organic Syntheses, Coll. Vol. 10, p. 501 (2004); Vol. 75, p. 61 (1998) or Organic Syntheses, Coll. Vol. 10, p. 102 (2004); Vol. 75, p. 53 (1998). 
     (1) Reduction of Cyano: 
                                
Wherein, L is a leaving group, selected from halogen, boric acid, methyl methanesulfonate or p-toluenesulfonates. B is a alkyl chain with one more carbon than M.
 
     The compounds represented by general formula ii-c can be prepared by reaction of intermediates ii-a and ii-b in proper solvent in the presence of proper base. The detailed operation refers to the methods described in US2002082454 and Fine Chemicals, 2005, 22(12): 944-960. The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. The proper solvent mentioned may be selected from acetone, butanone, tetrahydrofuran, acetonitrile, toluene, xylene, benzene, DMF, DMSO, methanol or ethanol and so on. Proper base mentioned may be selected from potassium hydroxide, sodium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, triethylamine, pyridine or sodium hydride. 
     When L refers to boric acid group, the compounds represented by general formula ii-c can also be prepared by reaction of intermediates ii-a and ii-b at 0-100° C. in proper solvent in the presence of proper base and catalyst. The proper solvent mentioned may be selected from benzene, toluene, xylene, chloroform, dichloromethane, acetone, butanone, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO and so on. Proper base mentioned may be selected from pyridine or triethylamine and so on. Proper catalyst mentioned may be selected from copper acetate, copper chloride or copper sulfate and so on. 
     The intermediates represented by general formula ii-1 can be prepared by reaction of intermediates represented by general formula ii-c and ammonia water in the presence of proper catalyst by using hydrogenation reduction. The detailed operation refers to the methods described in J. Am. Chem. Soc, 70, 3788 (1948); 82, 681 (1960); 82, 2386 (1960); Can. J. Chem, 49, 2990 (1971); J. Org. Chem, 37, 335 (1972); Organic Syntheses, Coll. Vol. 3, p. 229, p. 720 (1955), Vol. 23, p. 71 (1943) or Vol. 27, p. 18 (1947). The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. The proper solvent mentioned may be selected from methanol, ethanol, isopropanol, benzene, toluene, xylene, acetone, butanone, methylisobutylketone, chloroform, dichloroethane, methyl acetate, ethyl acetate, tetrahydrofuran, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO, etc. The proper catalysts mentioned may be selected from Raney-nickel, palladium carbon or platinum oxide, etc. 
     (2) The method to prepare the substituted amine and its salts by reaction of the substituted 4-hydroxyphenylalkyl amine 
     
       
                 
         
             
             
         
      
     
     Wherein, Boc 2 O refers to di-tert-butyl dicarbonate. 
     Firstly, the compounds represented by general formula ii-e can be prepared by reaction of intermediates ii-d and di-tert-butyl dicarbonate at 0-100° C. in proper solvent in the presence of proper base. The preferred temperature is 0-50° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 0.5-10 hours. The proper solvent mentioned may be selected from benzene, toluene, xylene, chloroform, dichloromethane, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO and so on. Proper base mentioned may be selected from alkali metal carbonate such as sodium carbonate, sodium bicarbonate, potassium carbonate or potassium bicarbonate. 
     Then the compounds represented by general formula ii-f can be prepared by reaction of intermediates ii-e and ii-b at 0-100° C. in proper solvent in the presence of proper base. The reaction time is in the range of 30 minutes to 20 hours, generally being 0.5-10 hours. The proper solvent mentioned may be selected from benzene, toluene, xylene, chloroform, dichloromethane, acetone, butanone, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO and so on. Proper base mentioned may be selected from alkali metal hydride such as sodium hydride; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali carbonate such as sodium carbonate or potassium carbonate; organic amine such as pyridine or triethylamine. 
     When L refers to boric acid group. The method to prepare the compounds represented by general formula ii-f refers to the method to prepare the compounds represented by general formula ii-c with method of cyano reduction. 
     The salts represented by general formula ii-g can be prepared by deprotection reaction of intermediates represented by general formula ii-f and proper acid in proper solvent, and then alkalized to obtain ii-1. The preferred temperature is 0-50° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 0.5-10 hours. The proper solvent mentioned may be selected from ethyl acetate, methyl acetate, methyl formate, benzene, toluene, xylene, chloroform, dichloromethane, water, tetrahydrofuran, acetonitrile, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO and so on, the proper acid mentioned may be selected from hydrochloric acid, trifluoroacetic acid, sulfuric acid, acetic acid, propionic acid, butyric acid, oxalic acid, 
     adipic acid, dodecanedioic acid, lauric acid, stearic acid, fumaric acid, maleic acid, benzoic acid or phthalic acid, etc. the proper base mentioned may be selected from alkali metal hydride such as sodium hydride; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali carbonate, such as sodium carbonate or potassium carbonate; organic amine, such as pyridine or triethylamine. The detailed operation refers to the methods described in WO2004093800A and US20050096485. 
     Other materials mentioned above, such as the compounds represented by general formula ii-a, ii-b, ii-d and Boc 2 O, used to prepare the compounds represented by general formula ii-1, are commercially available. 
     Method 2: when X 1 =N, the intermediate ii used to prepare the compounds represented by the general formula III (wherein A=NH) can be prepared according to the following two schemes in which B is selected from different substituent. 
     (1) When B=—CH 2 —, the detailed operation refers to the methods described in WO9404527, US20110054173 or WO2011025505. The compounds also can be prepared according to the following method. 
     
       
                 
         
             
             
         
      
     
     Wherein, U is a leaving group, selected from halogen or hydroxy, etc. 
     The intermediates represented by general formula ii-j can be prepared by reaction of intermediates represented by general formula ii-h and ii-i in proper solvent and temperature in the presence of proper base. The reaction time is in the range of 30 minutes to 20 hours, generally being 0.5-10 hours. The intermediates represented by general formula ii-k can be prepared by reduction reaction of intermediates represented by general formula ii-j and Red-Al, the detailed operation refers to the methods described in EP1840128. The intermediates represented by general formula ii-L can be prepared by reaction of intermediates represented by general formula ii-k and sulfoxide chloride according to known methods. The intermediates represented by general formula ii-m can be prepared by reaction of intermediates represented by general formula ii-L and sodium cyanide according to the methods described in WO2007045989 and WO2009115257. According to the methods described in Journal of Organic Chemistry, 71(21), 8023-8027; 2006, Synthesis, (24), 4242-4250, 2010, Heterocycles, 56(1-2), 443-455, 2002 or ARKIVOC (Gainesville, Fla., United States) [online computer file], (10), 40-51, 2002, The intermediates represented by general formula ii-n can be prepared via intermediate ii-m. Finally, the intermediates represented by general formula ii-2 can be prepared by reaction of intermediates represented by general formula ii-n and ammonia water in the presence of proper catalyst by using hydrogenation reduction. The detailed operation refers to the methods described in J. Am. Chem. Soc, 70, 3788(1948); 82, 681(1960); 82, 2386(1960); Can. J. Chem, 49, 2990(1971); J. Org. Chem, 37, 335(1972); Organic Syntheses, Coll. Vol. 3, p. 229, p. 720 (1955), Vol. 23, p. 71 (1943) or Vol. 27, p. 18 (1947). The proper catalysts mentioned may be selected from Raney-nickel, palladium carbon or platinum oxide, etc. 
     The sources of intermediates are as follows: the intermediate represented by general formula ii-h and ii-I are commercially available, or can be prepared according to the conventional method. 
     The proper base mentioned may be selected from potassium hydroxide, sodium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, triethylamine, pyridine, sodium methoxide, sodium ethoxide, sodium hydride, potassium tert-butoxide or sodium tert-butoxide and so on. 
     The reaction was carried out in proper solvent and the proper solvent mentioned may be selected from tetrahydrofuran, 1,4-dioxane, acetonitrile, toluene, xylene, benzene, DMF, N-methyl pyrrolidone, DMSO, acetone or butanone and so on. 
     The proper temperature mentioned is from room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. 
     The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. 
     (2) When B=—CH 2 CH 2 —, the preparation method is as follows: 
     
       
                 
         
             
             
         
      
     
     The compounds represented by general formula ii-o can be prepared by reaction of the compounds represented by general formula ii-n according to the methods described in Synthesis, (9), 727-9; 1983 or Tetrahedron Letters, 39(51), 9455-9456; 1998; the compounds having general formula ii-3 can be prepared by reaction of the compounds having general formula ii-o according to the methods in which B=—CH 2 —. 
     The second method to prepare the compounds represented by general formula PY: when A=NR 12  (R 12 ≠H), the compounds represented by general formula PY-2 can be prepared by reaction of the compounds represented by general formula PY-1 with U-R1 according to the conventional method (U defined as above); or can be prepared according to the methods described in JP08269021, JP3543411, JP1995-72621, JP1995-96669, JP3511729, JP08291149, EP530149, WO9208704 and WO2004093800A. 
     The third method to prepare the compounds represented by general formula PY: when A=O or S, the compounds represented by general formula PY-3, PY-4 can be prepared according to the methods described in WO2012075917 and EP534341. 
     The structural formula of the compounds represented by general formula PY-2, PY-3 and PY-4 are shown as follows 
     
       
                 
         
             
             
         
      
     
     In general formula PY, the corresponding salts represented by general formula PY-5A can be prepared by reaction of the compounds represented by general formula PY-5 (when A=NR 12 ) with corresponding organic acids or inorganic acids, as shown in the following. 
     
       
                 
         
             
             
         
      
     
     In addition, in general formula PY, the salts can also formed based on nitrogen atom of pyrimidine ring, the preparation method refers to DE19647317, JP2001504473, U.S. Pat. No. 5,925,644, WO9822446 and ZA9710187, etc. 
     The reaction forming salts of compounds represented by general formula PY-5 with organic acids or inorganic acids can be carried out at room temperature to boiling point of the solvent, normal temperature is from 20 to 100° C. The reaction time is in the range of 30 minutes to 20 hours, generally being 1-10 hours. The proper solvent mentioned may be selected from water, methanol, ethanol, isopropanol, benzene, toluene, xylene, acetone, ethyl methyl ketone, methyl isobutyl ketone, chloroform, dichloromethane, methyl acetate, ethyl acetate, tetrahydrofuran, 1,4-dioxane, DMF, N-methyl pyrrolidone or DMSO and so on. 
     The acids, which can be used to form salts with compounds represented by general formula PY-5, includes carboxylic acid, such as formic acid, acetic acid, propanoic acid, butyric acid, oxalic acid, trifluoroacetic acid, adipic acid, dodecanedioic acid, lauric acid, stearic acid, fumaric acid, maleic acid, sorbic acid, malic acid, citric acid, benzoic acid, p-toluylic acid or phthalic acid, etc. sulfonic acid, such as methanesulfonic acid, 1, 3-propylene sulfonic acid, p-toluenesulfonic acid or dodecylbenzene sulfonic acid, etc. inorganic acid, such as hydrochloric acid, sulphuric acid, nitric acid, phosphorous acid or carbonic acid, etc. The further preferred acids are hydrochloric acid, sulphuric acid, nitric acid, phosphorous acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid or benzoic acid. 
     Although the compounds represented by general formula PY and some compounds reported in prior art are both belong to substituted pyrimidine compounds, there are still some obvious differences in structure between them. It is due to these differences in structure that lead to compounds of present invention with better fungicidal and/or insecticidal/acaricidal activities. 
     The compounds represented by general formula PY show excellent activity against both many plant pathogens/diseases in agricultural and other fields, and insects/mites. Therefore the technical scheme of the present invention also includes the uses of the compounds represented by general formula PY or their salts/complexes to prepare fungicides, insecticides/acaricides in agricultural, forestry or public health fields. The further preferred technical scheme of the present invention also includes the uses of the compounds represented by general formula I, II or III or their salts/complexes to prepare fungicides, insecticides/acaricides in agricultural, forestry or public health fields. 
     The present invention is explained by the following examples of plant disease and insect pests, but without being restricted thereby. 
     The compounds represented by general formula PY can be used to control these plant diseases: Oomycete diseases, such as downy mildew (cucumber downy mildew, rape downy mildew, soybean downy mildew, downy mildew of beet, downy mildew of sugarcane, tobacco downy mildew, pea downy mildew, vegetable sponge downy mildew, chinese wax gourd downy mildew, muskmelon downy mildew, chinese cabbage downy mildew, spinach downy mildew, radish downy mildew, grape downy mildew, onion downy mildew), white rust (rape white rust, chinese cabbage white rust), damping-off disease (rape damping-off, tobacco damping-off, tomato damping-off, pepper damping-off, eggplant damping-off, cucumber damping-off, cotton damping-off),  pythium  rot (pepper soft stale disease, vegetable sponge cottony leak, chinese wax gourd cottony leak), blight (broad bean  phytophthora  blight, cucumber  phytophthora  blight, pumpkin  phytophthora  rot, chinese wax gourd  phytophthora  blight, watermelon  phytophthora  blight, muskmelon  phytophthora  blight, pepper  phytophthora  blight, chinese chives  phytophthora  blight, carlic  phytophthora  blight, cotton  phytophthora  blight), late blight (potato late blight, tomato late blight) and so on; diseases caused by Deuteromycotina, such as wilt disease (sweet potato  fusarium  wilt, cotton  fusarium  wilt disease, sesame wilt disease,  fusarium  wilt disease of costarbean, tomato  fusarium  wilt, bean  fusarium  wilt, cucumber  fusarium  wilt, vegetable sponge  fusarium  wilt, pumpkin  fusarium  wilt, chinese wax gourd  fusarium  wilt, watermelon  fusarium  wilt, muskmelon  fusarium  wilt, pepper  fusarium  wilt, broad bean  fusarium  wilt,  fusarium  wilt disease of rape,  fusarium  wilt disease of soybean), root rot (pepper root rot, eggplant root rot, bean  fusarium  root-rot, cucumber  fusarium  root rot, balsam pear  fusarium  root rot, cotton black root rot, broad bean  thielaviopsis  root rot), drooping disease (cotton soreshin, sesame soreshin, pepper  rhizoctonia  rot, cucumber  rhizoctonia  rot, chinese cabbage  rhizoctonia  rot), anthracnose (sorghum anthracnose, cotton anthracnose, kenaf anthracnose, jute anthracnose, flax anthracnose, tobacco anthracnose, mulberry anthracnose, pepper anthracnose, eggplant anthracnose, bean anthracnose, cucumber anthracnose, balsam pear anthracnose, summer squash anthracnose, chinese wax gourd anthracnose, watermelon anthracnose, muskmelon anthracnose, litchi anthracnose),  verticillium  wilt (cotton  verticillium  wilt,  verticillium  wilt of sunflower, tomato  verticillium  wilt, pepper  verticillium  wilt, eggplant  verticillium  wilt), scab (summer squash scab, chinese wax gourd scab, muskmelon scab), gray mold (cotton boll gray mold, kenaf gray mold, tomato gray mold, pepper gray mold, bean gray mold, celery gray mold, spinach gray mold, kiwi fruit gray mold rot), brown spot (cotton brown spot, jute brown spot, beet sercospora leaf spot, peanut brown spot, pepper brown leaf spot, chinese wax gourd  corynespora  leaf spot, soybean brown spot, sunflower brown spot, pea  ascochyta  blight, broad bean brown spot), black spot (flax black spot, rape  alternaria  leaf spot, sesame black spot, sunflower  alternaria  leaf spot, costarbean  alternaria  leaf spot, tomato nail head spot, pepper black fruit spot, eggplant black spot, bean leaf spot, cucumber  alternaria  blight, celery  alternaria  black leaf spot, carrot  alternaria  black rot, carrot leaf blight, apple  alternaria  rot, peanut brown spot), spot blight (tomato  septoria  leaf spot, pepper  septoria  leaf spot, celery late blight), early blight (tomato early blight, pepper early blight, eggplant early blight, potato early blight, celery early blight), ring spot (soybean zonate spot, sesame ring spot, bean zonate spot), leaf blight (sesame leaf blight, sunflower leaf blight, watermelon  alternaria  blight, muskmelon  alternaria  spot), basal stem rot (tomato basal stem rot, bean  rhizoctonia  rot), and others (corn northern leaf spot, kenaf damping-off, rice blast, millet black sheath, sugarcane eye spot, cotton  aspergillus  boll rot, peanut crown rot, soybean stem blight, soybean black spot, muskmelon  alternaria  leaf blight, peanut web blotch, tea red leaf spot, pepper  phyllosticta  blight, chinese wax gourd  phyllosticta  leaf spot, celery black rot, spinach heart rot, kenaf leaf mold, kenaf brown leaf spot, Jute stem blight, soybean  cercospora  spot, sesame leaf spot, costarbean gray leaf spot, tea brown leaf spot, eggplant  cercospora  leaf spot, bean  cercospora  leaf spot, balsam pear  cercospora  leaf spot, watermelon  cercospora  leaf spot, jute dry rot, sunflower root and stem rot, bean charcoal rot, soybean target spot, eggplant  corynespora  leaf spot, cucumber  corynespora  target leaf spot, tomato leaf mold, eggplant  fulvia  leaf mold, broad bean chocolate spot) and so on; diseases caused by Basidiomycete, such as rust (wheat stripe rust, wheat stem rust, wheat leaf rust, peanut rust, sunflower rust, sugarcane rust, chinese chives rust, onion rust, millet rust, soybean rust), smut (corn head smut, corn smut, sorghum silk smut, sorghum loose kernel smut, sorghum hard smut, sorghum smut, millet kernel smut, sugarcane smut, bean rust), and others (for example, wheat sheath blight and rice sheath blight) and so on; diseases caused by Ascomycete, such as powdery mildew (wheat powdery mildew, rape powdery mildew, powdery mildew of sesame, powdery mildew of sunflower, beet powdery mildew, eggplant powdery mildew, pea powdery mildew, vegetable sponge powdery mildew, pumpkin powdery mildew, summer squash powdery mildew, chinese wax gourd, muskmelon powdery mildew, grape powdery mildew, broad bean powdery mildew),  sclerotinia  rot (flax sclertiniose, rape sclertiniose, soybean sclertiniose, peanut sclertiniose, tobacco  sclerotinia  rot, pepper  sclerotinia  rot, eggplant  sclerotinia  rot, bean  sclerotinia  rot, pea  sclerotinia  rot, cucumber  sclerotinia  rot, balsam pear  sclerotinia  rot, chinese wax gourd  sclerotinia  rot, watermelon  sclerotinia  disease, celery stem rot), scab (apple scab, pear scab) and so on. Especially, the compounds of the present invention exhibit very good control against corn southern rust, rice blast, cucumber gray mold and cucumber downy mildew at very low doses. 
     The compounds represented by general formula PY can be used to control these insect pests: Coleoptera, such as  Acanthoscelides  spp.,  Acanthoscelides obtectus, Agrilus planipennis, Agriotes  spp.,  Anoplophora glabripennis, Anthonomus  spp.,  Anthonomus grandis, Aphidius  spp.,  Apion  spp.,  Apogonia  spp.,  Atacnius sprctulus, Atomaria linearis , pygmy mangold beetle,  Aulacophore  spp.,  Bothynoderes punctiventris, Bruchus  spp.,  Bruchus pisorum, Cacoesia, Cacoesia  spp.,  Callosobruchus maculatus, Carpophilus hemipteras, Cassida vittata, Cerosterna  spp.,  Ccrotoma, Ccrotoma  spp.,  Cerotoma trifur cata, Ceutorhynchus  spp.,  Ceutorhynchus assimilis , cabbage seedpod weevil,  Ceutorhynchus napi , cabbage curculio,  Chaetocnema  spp.,  Colaspis  spp.,  Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar, Cotinus nitidis , Green June beetle,  Crioceris asparagi, Cryptolestes ferrugincus , rusty grainbeetle,  Cryptolestes pusillus, Cryptolestes turcicus  Turkish grain beetle,  Ctenicera  spp.,  Curculio  spp.,  Cyclocephala  spp.,  Cylindrocpturus adspersus , sunflower stem weevil,  Deporaus marginatus , mango leaf-cutting weevil,  Dermestes lardarius, Dermestes maculates, Diabrotica  spp.,  Epilachna varivcstis, raustinus cubae, Hylobius pales , pales weevil,  Hypera  spp.,  Hypera postica, Hyperdoes  spp.,  Hyperodes weevil, Hypothenemus hampei, Ips  spp., engravers,  Lasioderma serricorne, Leptinotarsa decemlineata, Liogenys fuscus, Liogenys suturalis, Lissorhoptrus oryzophilus, Lyctus  spp., powder post beetles,  Maecolaspis joliveti, Megascelis  spp., Melanotus  communis, Meligethes  spp.,  Meligethes aeneus , blossom beetle,  Melolontha melolontha, Oberea brevis, Oberea linearis, Oryctes rhinoceros , date palm beetle,  Oryzaephilus mercator , merchant grain beetle,  Oryzaephilus surinamensis , sawtoothed grain beetle,  Otiorhynchus  spp.,  Oulema melanopus , cereal leafbeetle,  Oulema oryzae, Pantomorus  spp.,  Phyllophaga  spp.,  Phyllophaga cuyabana, Phyllotreta  spp.,  Phynchites  spp.,  Popillia japonica, Prostephanus truncates , larger grain borer,  Rhizopertha dominica , lesser grain borer,  Rhizotrogus  spp.,  Eurpoean chafer, Rhynchophorus  spp.,  Scolytus  spp.,  Shenophorus  spp.  Sitona lincatus , pca leaf weevil,  Sitophilus  spp.,  Sitophilus granaries , granary weevil,  Sitophilus oryzae , rice weevil,  Stegobium paniceum , drugstore beetle,  Tribolium  spp.,  Tribolium castaneum , red flour beetle,  Tribolium confusum , confused flour beetle,  Trogoderma variabile , warehouse beetle and  Zabrus tenebioides.    
     Dermaptera. 
     Dictyoptera, such as  Blattella germanica, German cockroach, Blatta orientalis, Parcoblatta pennylvanica, Periplaneta americana, American cockroach, Periplaneta australoasiae , Australian cockroach,  Periplancta brunnca , brown cockroach,  Periplaneta fuliginosa , smokybrown cockroach,  Pyncoselus suninamensis , Surinam cockroach and  Supella longipalpa , brownbanded cockroach. 
     Diptera, such as  Aedes  spp.,  Agromyza frontella , alfalfa blotch leafminer,  Agromyza  spp.,  Anastrepha  spp.,  Anastrepha suspensa , Caribbean fruit fly,  Anopheles  spp.,  Batrocera  spp.,  Bactrocera cucurbitae, Bactrocera dorsalis, Ceratitis  spp.,  Ceratitis capitata, Chrysops  spp.,  Cochliomyia  spp.,  Contarinia  spp.,  Culex  spp.,  Dasineura  spp.,  Dasineura brassicae, Delia  spp.,  Delia platura , seedcom maggot,  Drosophila  spp.,  Fannia  spp.,  Fannia canicularis , little house fly,  Fannia scalaris, Gasterophilus intestinalis, Gracillia perseae, Haematobia irritans, Hylemyia  spp., root maggot,  Hypoderma lineatum , common cattle grub,  Liriomyza  spp.,  Liriomyza brassica , serpentine leafminer,  Melophagus ovinus, Musca  spp., muscid fly,  Musca autumnalis , face fly,  Vusca domestica , house fly,  Oestrus ovis , sheep bot fly,  Oscinella frit, Pegomyia betae , beet leafminer,  Phorbia  spp.,  Psila rosae , carrotrust fly,  Rhagoletis cerasi , cherry fruit fly,  Rhagoletis pomonella , apple maggot,  Sitodiplosis mosellana , orange wheat blossom midge,  stomoxys  calcitruns, stable fly,  Tahanus  spp. and  Tipula  spp. 
     Hemiptera, such as  Acrosternum hilare , green stink bug,  Blissus leucopterus , chinch bug,  Calocoris norvegicus , potato mirid,  Cimex hemipterus , tropical bed bug,  Cimex lectularius , bed hug,  Daghertus fasciatus, Dichelops furcatus, Dysdercus suturellus , cotton stainer,  Edessa meditabunda, Eurygaster maura , cereal bug,  Euschistus heros, Euschistus servus , brown stink bug,  Helopeltis antonii, Helopeltis theivora , tea blight plantbug,  Lagynotomus  spp.,  Leptocorisa oratorius, Leptocorisa varicomi, Lygus  spp., plant bug,  Lygus hesperus , western tarnished plant bug,  Maconellicoccus hirsutus, Neurocolpus longirostris, Nezara viridula , southern green stink bug,  PhyLocoris  spp.,  Phytocoris californicus, Phytocoris relativus, Piezodorus guildingi, Poecilocapsus lineatus , fourlined plant bug,  Psallus vaccinicola, Pseudacysta perseae, Scaptocoris castanea  and  Triatoma  spp., bloodsuckingconenose bug, kissing bug. 
     Homoptera, such as  Acrythosiphonpisum , pea aphid,  Adelges  spp., adelgids,  Aleurodes proletella, Aleurodicus disperses, Aleurothrixus flccosus , woolly whitefly,  Aluacaspis  spp.,  Amrasca bigutella bigutella, Aphrophora  spp., leafhopper,  Aonidiella aurantii , California red scale,  Aphis  spp.,  Aphis gossypii , cotton aphid,  Aphis pomi , apple aphid,  Aulacorthitm solan , foxglove aphid,  Bemisia  spp.,  Bemisia argentifolii, Bemisia tabaci , sweetpotato whitefly,  Brachycolus noxius , Russian aphid,  Brachycorynclia asparagi , asparagus aphid,  Brevennia rehi, Brevicoryne brassicae, Ceroplastes  spp.,  Ceroplastes rubens , red wax scale,  Chionaspis  spp.,  Chrysomphalus  spp.,  Coccus  spp.,  Dysaphis plantaginea , rosy apple aphid,  Empoasca  spp.,  Eriosoma lanigerum , woolly apple aphid,  Icerya purchasi , cottony cushion scale,  Idioscopus nitidulus , mango leafhopper,  Laodelphax striatellus , smaller brown planthopper,  Lepidosaphes  spp.,  Macrosiphum  spp.,  Macrosiphum euphorbiae , potato aphid,  Macrosiphum granarium , English grain aphid,  Macrosiphum rosae , rose aphid,  Macrosteles quadrilineatus , aster leafhopper,  Mahanarva frimbiolata, Metopolophium dirhodum , rose grain aphid,  Midis longicornis, Myzus persicae , green peach aphid,  Nephotettix  spp.,  Nephotettix cinctipes , green leafhopper,  Nilaparvata lugens , brown planthopper,  Parlatoria pergandii , chaff scale,  Parlatoria ziziphi , ebony scale,  Peregrinus maidis , corn delphacid,  Philaenus  spp.,  Phylloxera vitifoliae , grape  phylloxera, Physokermes piceae , spruce bud scale,  Planococcus  spp.,  Pseudococcus  spp.,  Pseudococcus brevipes , pine apple mealybug,  Quadraspidiotus perniciosus , San Jose scale,  Rhapalosiphum  spp.,  Rhapalosiphum maida , corn leaf aphid,  Rhapalosiphum padi , oatbird-cherry aphid,  Saissetia  spp.,  Saissetia oleae, Schizaphis graminum , greenbug,  Sitobion avenge, Sogatella furcifera , white-backed planthopper,  Therioaphis  spp.,  Toumeyella  spp.,  Toxoptera  spp.,  Trialeurodes  spp.,  Trialeurodes vaporariorum , greenhouse whitefly,  Trialeurodes abutiloneus , bandedwing whitefly,  Unaspis  spp.,  Unaspis yanonensis , arrowhead scale and  Zulia entreriana.    
     Hymenoptera, such as  Acromyrrmex  spp.,  Athalia rosae, Atta  spp., leafcutting ants,  Camponotus  spp., carpenter ant,  Diprion  spp., sawfly,  Formica  spp.,  Iridomyrmex humilis, Argentineant, Monomorium  ssp.,  Monomorium minumum , little black ant,  Monomorium pharaonis , haraoh ant,  Neodiprion  spp.,  Pogonomyrmex  spp.,  Polistes  spp., paper wasp,  Solenopsis  spp.,  Tapoinoma sessile , odorous house ant,  Tetranomorium  spp., pavement ant,  Vespula  spp., yellow jacket and  Xylocopa  spp., carpenter bee. 
     Isoptera, such as  Coptotermes  spp.,  Coptotermes  curvignathus,  Coptotermes  frenchii,  Coptotermes formosanus , Formosan subterranean termite,  Cornitermes  spp., nasute termite,  Cryptotermes  spp.,  Heterotermes  spp., desert subterranean termite,  Ileterotermes aureus, Kalotermes  spp.,  Incistitermes  spp.,  Macrotermes  spp., fungus growing termite,  Marginitermes  spp.,  Microcerotermes  spp., harvester termite,  Microtermes obesi, Procornitermes  spp.,  Reticulitermes  spp.,  Reticulitermes banyulensis, Reticulitermes grassei, Reticulitermes flavipes, Reticulitermes hageni, Reticulitermes hesperus, Reticulitermes santonensis, Reticulitermes speratus, Reticulitermes tibialis, Reticulitermes virginicus, Schedorhinotermes  spp. and  Zootermopsis  spp. 
     Lepidoptera, such as  Achoea janata, Adoxophyes  spp.,  Adoxophyes orana, Agrotis  spp.,  Agrotis ipsilon, Alabama argillacea , cotton leafworm,  Amorbia cuneana, Amyelosis transitella , navel orangeworm,  Anacamptodes defectaria, Anarsia lineatella , peach twig borer,  Anomis sabulijera , jute looper,  Anticarsia gemmatalis , velvetbean caterpillar,  Archips argyrospila )(fruit tree leafroller,  Archips rosana , rose leaf roller,  Ar gyrotaenia  spp., tortricid moths,  Argyrotaenia citrana , orange  tortrix, Autographa gamma, Bonagota cranaodcs, Borbo cinnara , rice leaf folder,  Bucculatrix thurberiella , cotton leafperforator,  Caloptilia  spp.,  Capua reticulana, Carposina niponensis , peach fruit moth,  Chilo  spp.,  Chlumetia transversa , mango shoot borer,  Choristoneura rosaceana , oblique banded leaf roller,  Chrysodeixis  spp.,  Cnaphalocerus medinalis , grass leafroller,  Colias  spp.,  Conpomorpha cramerella, Cossus cossus, Crambus  spp., Sod webworms,  Cydia funebrana , plum fruit moth,  Cydia molesta , oriental fruit moth,  Cydia nignicana , pea moth,  Cydia pomonella , codling moth,  Darna diducta, Diaphania  spp., stem borer,  Diatr  aea spp., stalk bor er,  Diatraea saccharalis , sugarcane borer,  Diatraea graniosella , southwester corn borer,  Earias  spp.,  Earias insulata , Egyptian bollworm,  Earias vit.ella , rough northern bollworm,  Ecdytopopha aurantianum, Elasmopalpus lignosellus , lesser cornstalk borer,  Epiphysias postruttana , light brown, apple moth,  Ephestia  spp.,  Ephestia cautella , almond moth,  Ephestia elutella , tobbaco moth,  Ephestia kuehniella , Mediterranean flour moth,  Epimeces  spp,  Epinotia aporema, Erionota thrax , banana skipper,  Eupoecilia ambiguella , grape berry moth,  Euxoa auxiliaris , army cutworm,  Feltia  spp.,  Gortyna  spp.,  Grapholita molesta , oriental fruit moth,  Hedylepta indicata , bean leaf webber,  Helicoverpa  spp.,  Helicoverpa armigera , cotton bollworm,  Helicoverpa zea, Heliothis  spp.,  Heliothis virescens , tobacco budworm,  Hellula undalis , cabbage webworm,  Indarbela  spp.  Keiferia lycopersicella , tomato pinworm,  Leucinodes orbonalis , eggplant fruit borer,  Leucoptera malifoliella, Lithocollectis  spp.,  Lobesia botrana , grape fruit moth,  Loxagrotis  spp.,  Loxagrotis albicosta , western bean cutworm,  Lymantria dispar , gypsy moth,  Lyonetiaclerkella , apple leafminer,  Mahasena corbetti , oil palm bagworm,  Malacosoma  spp., tent caterpillars,  Mamestra brassicae , cabbage armyworm,  Maruca testulalis, Metisa plana, Mythimna unipuncta , true armyworm,  Neoleucinodes elegantalis , small tomato borer,  Nymphula depunctalis , rice caseworm,  Operophthera brumata , winter moth,  Ostrinia nubilalis , European corn borer,  Oxydia vesulia, Pandemis cerasana , common currant  tortrix, Pandemis heparana , brown apple  tortrix, Papilio demodocus, Pectinophora gossypiella , pink bollworm,  Peridroma  spp.,  Peridroma saucia , variegated cutworm,  Perileucoptera coffeella , white coffee leafminer,  Phthorimaea operculella , potato tuber moth,  Phyllocnisitis citrella, Phyllonorycter  spp.,  Pieris rapae , imported cabbageworm,  Plathypena scabra, Plodia interpunctella , Indian meal moth,  Plutella xylostella , diamondback moth,  Polychrosis viteana , grape berry moth,  Prays endocarps, Prsys oleae , olive moth,  Pseudaletia  spp.,  Pseudaletia unipunctata, Pseudoplusia includens , soybean looper,  Rachiplusia nu, Scirpophaga incertulas, Sesamia  spp.,  Sesamia inferens , pink rice stemborer,  Sesamia nonagrioides, Setora nitens, Sitotroga cerealella, Angoumois  grain moth,  Sparganothis pilleriana, Spodoptera  spp.,  Spodoptera exigua , beet armyworm,  Spodoptera fugiperda , fall armyworm,  Spodoptera oridania , southern armyworm,  Synanthedon  spp.,  Thecla basilides, Thermisia gemmatalis, Tineola bisselliella , webbing clothes moth,  Trichoplusia ni , cabbage looper,  Tuts absoluta, Yponomeuta  spp.,  Zeuzeracoffeae , red branch borer and  Zeuzera pyrina , eopard moth. 
     Mallophaga, chewing lice, such as  Bovicola ovis , sheep biting louse,  Menacanthus stramineus , chicken body louse and  Menopon gallinea , common hen house, 
     Orthoptera, such as  Anabrus simplex , Mormon cricket, Gryllotalpidae, mole cricket,  Locusta migratoria, Melanoplus  spp.,  Microcentrum retinerve , angular winged katydid,  Pterophylla  spp.,  histocerca gregaria, Scudderia furcata , fork tailed bush katydid and  Valanga nigricorni , sucking louse, such as  Haematopinus  spp.,  Linognathus ovillus , sheep louse,  Pediculus humanus capitis, Pediculus humanus humanus  and  Pthirus pubis , crab louse. 
     Siphonaptera, such as  Ctenocephal ides canis , dog flea,  Ctenocephalides felis , cat flea and  Pulex irritanshuman  flea. 
     Thysanoptera, such as  Frankliniella fusca , tobacco thrip,  Frankliniella occidentalis , western flower thrips,  Frankliniella shultzei, Frankliniella williamsi , corn thrip,  IIeliothrips haemorrhaidalis , greenhouse thrip,  Riphiphorothrips cruentatus, Scirtothrips  spp,  Scirtothrips cirri , citrus thrip,  Scirtothrips dorsalis , yellow tea thrips,  Taeniothrips rhopalantennalis  and  Thrips  spp. 
     Thysanura, bristletail, such as  Lepisma  spp, silverfish and  Thermobia  spp. 
     Acarina, mite and tick, such as  Acarapsis woodi , tracheal mite of honeybee,  Acarus  spp.,  Acarus siro , grain mite,  Aceria mangiferae , mango bud mite,  Aculops  spp.,  Aculops lycopersici , tomato russet mite,  Aculops pelekasi, Aculus pelekassi, Aculus schlechtendali , apple rust mite,  Amblyomma americanum , lone star tick,  Boophilus  spp.,  Brevipalpus obovatus , privet mite,  Brevipalpus phoenicis , red and black flat mite,  Demodex  spp., mange mites,  Dermacentor  spp.,  Dermacentor variabilis , american dog tick,  Dermatophagoides pteronyssinus , house dust mite,  Eotetranycus  spp.,  Eotetranychus carpini , yellow spider mite,  Epitimerus  spp.,  Eriophyes  spp.,             ; odes spp.,  Metatetranycus  spp.,  Notoedres cati, Oligonychus  spp.,  Oligonychus  coffee,  Oligonychus ilicus , southernred mite,  anonychus  spp.,  Panonychus cirri , citrus red mite,  Panonychus ulmi , European red mite,  Phyllocoptruta oleivora , citrus rust mite,  Polyphagotarsonemun latus , broad mite,  Rhipicephalus sanguineus , brown dog tick,  Rhizoglyphus  spp., bulb mite,  Sarcoptes scabiei , itch mite,  Tegolophus perseaflorae, Tetranychus  spp.,  Tetranychus urticae , twospotted spider mite and  Varroa destructor.  
     Nematoda, such as  Aphelenchoides  spp., bud and leaf &amp; pine wood nematode,  Belonolaimus  spp., sting nematodes,  Criconemella  spp., ring nematodes,  Dirofilaria immitis , dog heartworm,  Ditylenchus  spp.,  Heterodera  spp., cyst nematode,  Heterodera zeae , corn cyst nematode,  Hirschmanniella  spp., root nematodes,  Hoplolaimus  spp., lance nematodes,  Meloidogyne  spp.,  Meloidogyne incognita, Onchocerca volvulus , hook-tail worm,  PraLylenchus  spp., lesion nematode,  Radopholus  spp., burrowing nematode and  Rotylenchus reniformis , kidney-shaped nematode. 
     Symphyla, such as  Scutigerella immaculata.    
     Especially, the compound represented by the present invention provides great control effects against peach aphid, diamondback moth, armyworm, and carmine spider mite, and acquires great effects at a minimal dosage. 
     Due to their positive characteristics, the compounds mentioned above can be advantageously used in protecting crops of farming and gardening, domestic and breeding animals, as well as environments frequented by human beings, from pathogens, insects and pest mites. 
     In order to obtain desired effect, the dosage of the compound to be applied can vary with various factors, for example, the used compound, the protected crop, the type of harmful organism, the degree of infestation, the climatic conditions, the application method and the adopted formulation. 
     The dosage of compounds in the range of 10 g to 5 kg per hectare can provide a sufficient control. 
     A further object of the present invention also includes fungicidal, insecticidal/acaricidal compositions containing the compounds having general formula PY as active ingredient, and the weight percentage of the active ingredient in the composition is 0.1-99%. The fungicidal, insecticidal/acaricidal compositions also include the carrier being acceptable in agriculture, forestry, public health. 
     Especially, a preferred object of the present invention also includes fungicidal, insecticidal/acaricidal compositions containing the compounds and its salts/complexes having general formula I, II or III as active ingredient, wherein the weight percentage of the active ingredient in the composition is 0.1-99%. 
     The compositions of the present invention can be used in the form of various formulations. Usually, the compounds having general formula PY as active ingredient can be dissolved in or dispersed in carriers or made to a formulation so that they can be easily dispersed as an fungicide or insecticide. For example: these chemical formulations can be made into wettable powder, oil miscible flowable, aqueous suspension, aqueous emulsion, aqueous solution or emulsifiable concentrates. Therefore, in these compositions, at least a liquid or solid carrier is added, and usually suitable surfactant(s) can be added when needed. 
     Still also provided by the present invention are the application methods for controlling phytopathogenic fungi, insects, pest mites: which is to apply the compositions of the present invention to the phytopathogenic fungi, insects, pest mites as mentioned above or their growing loci. The suitable effective dosage of the compounds of the present invention is usually within a range of 10 g/ha to 1000 g/ha, preferably from 20 g/ha to 500 g/ha. For some applications, one or more other fungicides, insecticides/acaricides, herbicides, plant growth regulators or fertilizer can be added into the fungicidal, insecticidal/acaricidal compositions of the present invention to make additional merits and effects. 
     It should be noted that variations and changes are permitted within the claimed scopes in the present invention. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The present invention is illustrated by the following examples, but without being restricted thereby. (All raw materials are commercially available unless otherwise specified.) 
     PREPARATION EXAMPLES 
     Example 1: The Preparation of Intermediate 4,5-dichloro-6-methylpyrimidine 
     1) The Preparation of 4-hydroxyl-5-chloro-6-methylpyrimidine 
     
       
                 
         
             
             
         
      
     
     8.80 g (0.16 mol) of CH 3 ONa in methanol was added slowly to a solution of 11.30 g (0.11 mol) of formimidamide in 50 mL of methanol at room temperature under stirring, the mixture was stirred for another 2 hrs after addition at room temperature. Followed by addition of 11.17 g (0.068 mol) of ethyl 2-chloro-3-oxobutanoate, the mixture was continued stirring for another 5-7 hrs at room temperature. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure and pH was adjusted to 5-6 with HCl, and then filtered to afford orange-yellow solid, the water phase was extracted with ethyl acetate (3×50 mL), dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was dissolved to 50 ml of ethyl acetate, stand overnight to obtain 6.48 g as orange-yellow solid with yield of 66%. m.p. 181-184° C. 
     2) The Preparation of Intermediate 4,5-dichloro-6-methylpyrimidine 
     
       
                 
         
             
             
         
      
     
     50 ml of POCl 3  was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 hrs after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl 3 , and then poured into ice water. The water phase was extracted with ethyl acetate (3×50 mL), the organic phases were emerged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column to give 14.43 g as yellow liquid with yield of 88.5%. 
     Example 2: The Preparation of Intermediate 4,5-dichloro-6-(difluoromethyl)pyrimidine 
     1) The Preparation of 2-dichloro-4,4-difluoro-3-oxobutanoate 
     
       
                 
         
             
             
         
      
     
     177.46 g (1.33 mol) of sulfonyl chloride in 200 mL dichloromethane was added slowly to a solution of 200.00 g (1.20 mol) of ethyl 4,4-difluoro-3-oxobutanoate in 300 mL of dichloromethane at room temperature under stirring for 3 hrs, then a lot of gas released out after addition, the mixture was continued stirring for another 5-7 hrs at room temperature. After the reaction was over by Thin-Layer Chromatography monitoring, the excess solvent and sulfonyl chloride were concentrated under reduced pressure to obtain 240 g as faint yellow liquid. 
     2) The Preparation of 4-hydroxyl-5-chloro-6-(difluoromethyl)pyrimidine 
     
       
                 
         
             
             
         
      
     
     A solution of 71.9 g (0.70 mol) of formimidamide in 150 mL of methanol was stirred at 5-10° C., 64.6 g (1.20 mol) of CH 3 ONa in methanol prepared and cooled to room temperature ahead of time was added slowly to the above solution under stirring, followed by addition of 100 g (0.50 mol) of ethyl 2-chloro-4,4-difluoro-3-oxobutanoate in 100 ml of methanol, the mixture was continued stirring for another 3-4 hrs at room temperature. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure and pH was adjusted to 5-6 with HCl, and then filtered to afford 65 g as white solid with yield of 73%. m.p. 204-206° C. 
     3) The Preparation of 4,5-dichloro-6-(difluoromethyl)pyrimidine 
     
       
                 
         
             
             
         
      
     
     100 ml of POCl 3  was added dropwise to a solution of 65.0 g (0.36 mol) of 4-hydr oxyl-5-chloro-6-(difluoromethyl)pyrimidin in 150 mL of toluene, the mixture was refluxed for 3-5 hrs after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl 3 , and then poured into ice water. The water phase was extracted with ethyl acetate (3×50 mL), the organic phases were emerged, washed with saturated sodium bicarbonate, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column to give 64.5 g as yellow liquid, cooled to be solid in refrigerator with yield of 9 0%. 
     Example 3: The Preparation of 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 
     1) The Preparation of 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)acetonitrile 
     
       
                 
         
             
             
         
      
     
     To a solution of 2-chloro-5-(trifluoromethyl)pyridine 18.15 g (0.1 mol) and 2-(4-hydroxyphenyl)acetonitrile 15.96 g (0.12 mol) in 200 mL butanone was added potassium carbonate 27.60 g (0.2 mol). The reaction mixture was continued stirring and heating to reflux for 4-10 hrs, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure. Then the mixture was poured into 200 mL of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of 5% aqueous solution of NaOH, and 50 mL of brine successively, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:5, as an eluent) to obtain 22.50 g target intermediate as white solid with yield of 81.5%, m.p. 48-49 □. 
     2) The Preparation of 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 
     
       
                 
         
             
             
         
      
     
     To a solution of 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)acetonitrile 2.78 g (0.01 mol), Raney nickel (1.0 g) and 10 mL of 25% aqueous ammonia in 50 mL ethanol was filled with hydrogen, then the reaction mixture was continued stirring at room temperature for 3-15 hrs and monitored by TLC until the reaction was over, Raney nickel was filtered, the solution was concentrated under reduced pressure to give sticky oil cooled to obtain 2.20 g target intermediate as white solid with yield of 78%, m.p. 82-83° C. 
     Example 4: The Preparation of 4-(2-(5-chloro-6-methylpyrimidin-4-ylamino)ethyl)phenol 
     
       
                 
         
             
             
         
      
     
     To a solution of 4-(2-aminoethyl)phenol 1.13 g (0.01 mol) and triethylamine 2.02 g (0.02 mol) in 50 mL toluene was dropwise added 4,5-dichloro-6-methylpyrimidine 1.63 g (0.01 mol). The reaction mixture was continued stirring for 4-10 hrs, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 2.10 g target intermediate as white solid with yield of 88%, m.p. 177-179° C. 
     Example 5: The Preparation of Intermediate 2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)ethanamine 
     1) tert-butyl 4-hydroxyphenethylcarbamate 
     
       
                 
         
             
             
         
      
     
     To a solution of 4-(2-aminoethyl)phenol 11.3 g (0.1 mol) and sodium bicarbonate 10.08 g (0.12 mol) in 80 mL tetrahydrofuran was dropwise added di-tert-butyl dicarbonate 21.80 g (0.1 mol) at room temperature, then the reaction mixture was continued stirring for 4-10 hrs, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure. Then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 17.15 g target intermediate as white solid with yield of 81%, m.p. 48-49° C.
         2) The Preparation of tert-butyl 4-(3,5,6-trichloropyridin-2-yloxy)phenethylcarbamate       

     
       
                 
         
             
             
         
      
     
     To a solution of tert-butyl 4-hydroxyphenethylcarbamate 2.37 g (0.01 mol) and 2,3,5,6-tetrachloropyridine 2.17 g (0.01 mol) in 50 mL butanone was added potassium carbonate 2.76 g (0.02 mol). The reaction mixture was continued stirring and heating to reflux for 4-10 hrs, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:5, as an eluent) to obtain 3.55 g target intermediate as white solid with yield of 82%, m.p. 48-49° C. 
     3) The Preparation of 2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)ethanamine hydrochloride 
     
       
                 
         
             
             
         
      
     
     To a solution of tert-butyl 4-(3,5,6-trichloropyridin-2-yloxy)phenethylcarbamate 4.17 g (0.01 mol) in 50 mL ethyl acetate was dropwise added 15 mL concentrated hydrochloric acid. The reaction mixture was Gradually dissolved and continued stirring for 4-5 hrs, then a large amount of solid was precipitated and filtered, the filter cake was washed with 50 mL ethyl acetate to obtain 3.0 g target intermediate as white solid with yield of 88%, m.p. 48-49° C. 
     Example 6: The Preparation of Compound I-22 
     
       
                 
         
             
             
         
      
     
     To a solution of 4,5-dichloro-6-methylpyrimidine 1.63 g (0.01 mol) and 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 2.82 g (0.01 mol) in 50 mL toluene was added triethylamine 2.02 g (0.02 mol) after the reaction mixture was dissolved. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 3.25 g compound I-22 as white solid with yield of 80%, m.p. 98-99° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 2.46 (3H, s), 2.97 (2H, t), 3.79 (2H, q), 5.47 (1H, t), 7.01 (1H, d), 7.12 (2H, d), 7.29 (2H, d), 7.90 (1H, d), 8.40 (1H, d), 8.44 (1H, s). 
     Example 7: The Preparation of Compound I-254 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.77 g (0.01 mol) 4,5-dichloro-6-ethylpyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to ethyl 2-chloro-3-oxopentanoate) and 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 2.82 g (0.01 mol) in 50 mL toluene was added triethylamine 2.02 g (0.02 mol). The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 3.56 g compound I-254 as white solid with yield of 83%, m.p. 76˜78° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 1.26 (3H, t), 2.79 (2H, q), 2.77 (4H, m), 2.97 (2H, t), 3.79 (2H, q), 5.51 (1H, t), 7.00 (1H, d), 7.11 (2H, d), 7.29 (2H, d), 7.89 (1H, d), 8.44 (2H, m). 
     Example 8: The Preparation of Compound I-483 
     
       
                 
         
             
             
         
      
     
     To a solution of 4-(2-(5-chloro-6-methylpyrimidin-4-ylamino)ethyl)phenol 2.64 g (0.01 mol) and 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 2.33 g (0.01 mol) in 30 mL N,N-dimethyl formamide was added potassium carbonate 2.76 g (0.02 mol). The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 3.77 g compound I-483 as colorless oil with yield of 82%. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.45 (3H, s), 2.96 (2H, t), 3.72-3.84 (2H, q), 5.45 (1H, t), 7.13 (2H, d), 7.29 (2H, d), 7.99 (1H, d), 8.27 (1H, s), 8.40 (1H, s). 
     Example 9: The Preparation of Compound I-583 
     
       
                 
         
             
             
         
      
     
     To a solution of 2.78 g (0.01 mol) 4-(2-(5-chloro-6-ethylpyrimidin-4-ylamino)ethyl)phenol (the preparation refers to Example 3, the difference is replacing 4,5-dichloro-6-methylpyrimidine to 4,5-dichloro-6-ethylpyrimidine) and 2,3,5-trichloropyridine 1.83 g (0.01 mol) in 30 mL N,N-dimethyl formamide was added potassium carbonate 2.76 g (0.02 mol). The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 3.50 g compound I-583 as colorless oil with yield of 83%, m.p. 53-54° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.26 (3H, t), 2.79 (2H, q), 2.96 (2H, q), 3.77 (2H, q), 5.47 (1H, t), 7.11 (2H, d), 7.28 (2H, d), 7.77 (1H, s), 8.45 (1H, s). 
     Example 10: The Preparation of Compound I-2342 
     
       
                 
         
             
             
         
      
     
     To a solution of 4,5-dichloro-6-(difluoromethyl)pyrimidine 1.99 g (0.01 mol) and 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine 2.82 g (0.01 mol) in 50 mL toluene was added triethylamine 2.02 g (0.02 mol) after the reaction mixture was dissolved. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 3.82 g compound I-2342 as white solid with yield of 86%, m.p. 102-103° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 8.581 (s, 1H, pyrimidine-H), 8.439 (s, 1H, pyridine-6-H), 7.891-7.927 (d, 1H, pyridine-4-H), 7.008-7.037 (d, 1H, pyridine-3-H), 7.111-7.310 (dd, 4H, Ar—H), 6.547-6.904 (t, 1H, F 2 C—H, 5.747 (s, 1H, NH), 3.815-3.882 (q, 2H, N—CH 2 —C), 2.964-3.010 (t, 2H, C—CH 2 —Ar). 
     Example 11: The Preparation of Compound I-2574 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.99 g (0.01 mol) 4,5-dichloro-6-(difluoromethyl)pyrimidine and 2.82 g (0.01 mol) 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine (the preparation refers to Example 3) in 50 mL toluene was added triethylamine 2.02 g (0.02 mol) after the reaction mixture was dissolved. The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 4.16 g compound I-2574 as white solid with yield of 84%. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): δ 8.577 (s, 1H, pyrimidine-H), 8.270 (s, 1H, pyridine-6-H), 7.981-7.987 (d, 1H, pyridine-4-H), 7.128-7.319 (dd, 4H, Ar—H), 6.716 (t, 1H, F 2 C—H), 3.843-3.864 (q, 2H, N—CH 2 —C), 2.970-3.016 (t, 2H, C—CH 2 —Ar). 
     Example 12: The Preparation of Compound I-2748 
     
       
                 
         
             
             
         
      
     
     To a solution of 2.17 g (0.01 mol) 4,5-dichloro-6-(trifluoromethyl)pyrimidine (the preparation refers to Example 1) and 3.19 g (0.01 mol) 2-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethanamine in 50 mL toluene was added triethylamine 2.02 g (0.02 mol). The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 4.07 g compound I-2748 as white solid with yield of 88%, m.p. 96-97° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 8.577 (s, 1H, pyrimidine-H), 8.436 (s, 1H, pyridine-6-H), 7.892-7.920 (d, 1H, pyridine-4-H), 7.010-7.039 (d, 1H, pyridine-3-H), 7.115-7.313 (dd, 4H, Ar—H), 5.898 (s, 1H, NH), 3.825-3.890 (q, 2H, N—CH 2 —C), 2.966-3.014 (t, 2H, C—CH 2 —Ar). 
     Example 13: The Preparation of Compound I-3309 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.77 g (0.01 mol) 4,5-dichloro-6-ethylpyrimidine and 2.50 g (0.01 mol) 2-(4-(6-chloropyridazin-3-yloxy)phenyl)ethanamine (the preparation refers to Example 3, the difference is replacing 2-chloro-5-(trifluoromethyl)pyridine to 3,6-dichloropyridazine) in 50 mL toluene was added 2.02 g (0.02 mol)triethylamine after the reaction mixture was dissolved. The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 3.40 g compound I-3309 as white solid with yield of 87%, m.p. 138-140° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.25 (3H, t), 2.79 (2H, q), 2.96 (2H, t), 3.78 (2H, q), 5.50 (1H, s), 7.16 (3H, m), 7.26 (2H, m), 7.50 (1H, d), 8.45 (1H, s). 
     Example 14: The Preparation of Compound I-4757 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.63 g (0.01 mol) 4,5-dichloro-6-methylpyrimidine and 2.75 g (0.01 mol) 2-(4-(4,6-dimethoxypyrimidin-2-yloxy)phenyl)ethanamine (the preparation refers to Example 3, the difference is replacing 2-chloro-5-(trifluoromethyl)pyridine to 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine) in 50 mL toluene was added 2.02 g (0.02 mol)triethylamine after the reaction mixture was dissolved. The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 3.24 g compound I-4757 as white solid with yield of 81%, m.p. 119-120° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.46 (3H, s), 2.95 (2H, t), 3.82 (2H, m), 3.84 (6H, s), 5.43 (1H, s), 5.78 (1H, s), 7.26 (4H, m), 8.40 (1H, s). 
     Example 15: The Preparation of Compound I-6730 
     
       
                 
         
             
             
         
      
     
     To a solution of compound I-22 0.41 g (0.01 mol) in 20 mL ethanol was dropwise added 10 mL of concentrated hydrochloric acid at room temperature, The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, the brown residue was washed with (3×50 mL) of acetone to obtain 0.33 g compound I-6730 as white solid with yield of 75%, m.p. 108-110° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 2.49 (3H, s), 2.88 (2H, t), 3.64 (2H, m), 7.08 (2H, d), 7.17 (1H, d), 7.35 (2H, d), 7.37 (1H, m), 8.16 (1H, d), 8.25 (1H, s), 8.50 (1H, s). 
     Example 16: The Preparation of 2-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)ethanamine 
     1) The Preparation of 2-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)acetonitrile 
     
       
                 
         
             
             
         
      
     
     To a solution of 150 mL N,N-dimethyl formamide was added 1,2-dichloro-4-(trifluoromethyl)benzene 25.8 g (0.12 mol), 2-(4-hydroxyphenyl)acetonitrile 13.3 g (0.1 mol) and potassium carbonate 27.60 g (0.2 mol). The reaction mixture was continued stirring and heating to reflux overnight, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure. Then the mixture was poured into 300 mL of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of 5% aqueous solution of NaOH, and 50 mL of brine successively, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 14.55 g target intermediate as white solid with yield of 46.2%, m.p. 66.2° C. 
     2) The Preparation of 2-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)ethanamine hydrochloride 
     
       
                 
         
             
             
         
      
     
     To a solution of 2-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)acetonitrile 3.12 g (0.01 mol), Raney nickel (1.0 g) and 10 mL of 25% aqueous ammonia in 50 mL ethanol was filled with hydrogen at high pressure, then the reaction mixture was continued stirring at room temperature for 3 hours and monitored by TLC until the reaction was over, Raney nickel was filtered, the solution was concentrated under reduced pressure to give sticky liquid. To a solution of the residue was dropwise added 5 mL of concentrated hydrochloric acid and stirred for half an hour at room temperature until target intermediate precipitated, filtered to obtain 3.45 g white solid with yield of 97.9%, m.p. 155.7° C. 
     Example 17: The Preparation of 2-(4-(2,6-dichloro-4-nitrophenoxy)phenyl)ethanamine hydrochloride 
     1) The Preparation of tert-butyl 4-(2,6-dichloro-4-nitrophenoxy)phenethylcarbamate 
     
       
                 
         
             
             
         
      
     
     To a solution of tert-butyl 4-hydroxyphenethylcarbamate 2.10 g (0.01 mol) and 1,3-dichloro-2-fluoro-5-nitrobenzene 2.33 g (0.01 mol) in 50 mL butanone was added potassium carbonate 2.76 g (0.02 mol). The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 3.73 g target intermediate as white solid with yield of 87.3%, m.p. 149-151° C. 
     2) The Preparation of 2-(4-(2,6-dichloro-4-nitrophenoxy)phenyl)ethanamine 
     
       
                 
         
             
             
         
      
     
     To a solution of tert-butyl 4-(2,6-dichloro-4-nitrophenoxy)phenethylcarbamate 4.27 g (0.01 mol) in 50 mL ethyl acetate was dropwise added 6 mL trifluoroacetic acid until the solid was dissolved at room temperature for 4-5 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure to give 3.03 g target intermediate as white solid with yield of 92.8%, m.p. 107-109° C. 
     Example 18: The Preparation of 2-(4-(4-(trifluoromethyl)phenoxy)phenyl)ethanamine 
     1) The Preparation of tert-butyl 4-(4-(trifluoromethyl)phenoxy)phenethylcarbamate 
     
       
                 
         
             
             
         
      
     
     To a solution of 4-(trifluoromethyl)phenylboronic acid 4.56 g (0.024 mol) in 50 mL dichloromethane was added 4A molecular sieve powder, Cupric Acetate Anhydrous 3.82 g (0.021 mol), triethylamine 10.1 g (0.1 mol), and pyridine 7.9 g (0.1 mol) successively; The reaction mixture was continued to react overnight, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, filtered and the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 5.95 g target intermediate as white solid with yield of 65.1%. 
     2) The Preparation of 2-(4-(4-(trifluoromethyl)phenoxy)phenyl)ethanamine hydrochloride 
     
       
                 
         
             
             
         
      
     
     To a solution of tert-butyl 4-(4-(trifluoromethyl)phenoxy)phenethylcarbamate 3.81 g (0.01 mol) in 50 mL ethyl acetate was dropwise added 12 mL concentrated hydrochloric acid. The reaction mixture was continued to stir for 4-5 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to react for half an hour and filtered to give 2.92 g target intermediate as white solid with yield of 91.9%. 
     Example 19: The Preparation of Compound II-69 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.63 g (0.01 mol) 4,5-dichloro-6-methylpyrimidine and 3.18 g (0.01 mol) 2-(4-(4-(trifluoromethyl)phenoxy)phenyl)ethanamine hydrochloride in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 2.76 g compound II-69 as colourless oil with yield of 72.6%. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.46 (3H, s), 2.94 (2H, t), 3.77 (2H, q), 5.42 (1H, s), 702 (4H, m), 7.25 (2H, m), 7.56 (2H, d), 8.39 (1H, s). 
     Example 20: The Preparation of Compound II-165 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.63 g (0.01 mol) 4,5-dichloro-6-methylpyrimidine and 3.26 g (0.01 mol) 2-(4-(2,6-dichloro-4-nitrophenoxy)phenyl)ethanamine in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure. Then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 3.23 g compound II-165 as rufous solid with yield of 71.2%, m.p. 118-120° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.45 (3H, s), 2.91 (2H, t), 3.70-3.85 (2H, q), 5.42 (1H, t), 6.80 (2H, d), 7.18 (2H, d), 8.31 (2H, s), 8.38 (1H, s). 
     Example 21: The Preparation of Compound II-297 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.77 g (0.01 mol) 4,5-dichloro-6-ethylpyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to ethyl 2-chloro-3-oxopentanoate) and 2.84 g (0.01 mol) 2-(4-(4-chlorophenoxy)phenyl)ethanamine hydrochloride (the preparation refers to Example 18, the difference is replacing 4-(trifluoromethyl)phenylboronic acid to 4-chlorophenylboronic acid) in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 3.16 g compound II-297 as rufous solid with yield of 81.6%, m.p. 84.7° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.26 (3H, t), 2.78 (2H, dd), 2.92 (2H, t), 3.75 (2H, dd), 5.45 (1H, t), 6.84-7.00 (4H, m), 7.20 (2H, d), 7.29 (2H, d), 8.44 (1H, s). 
     Example 22: The Preparation of Compound II-303 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.77 g (0.01 mol) 4,5-dichloro-6-ethylpyrimidine and 3.19 g (0.01 mol) 2-(4-(3,5-dichlorophenoxy)phenyl)ethanamine hydrochloride (the preparation refers to Example 18, the difference is replacing 4-(trifluoromethyl)phenylboronic acid to 3,5-dichlorophenylboronic acid) in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 3.17 g compound II-303 as pale rufous oil with yield of 75.1%. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.26 (3H, t), 2.78 (2H, dd), 2.95 (2H, t), 3.72-3.84 (2H, q), 5.45 (1H, t), 6.85 (2H, d), 7.00 (2H, d), 7.25 (2H, d), 8.45 (1H, s). 
     Example 23: The Preparation of Compound II-347 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.77 g (0.01 mol) 4,5-dichloro-6-ethylpyrimidine and 3.18 g (0.01 mol) 2-(4-(4-(trifluoromethyl)phenoxy)phenyl)ethanamine hydrochloride in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 3.15 g compound II-347 as white solid with yield of 74.8%, m.p. 52.6° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.27 (3H, t), 2.78 (2H, q), 2.95 (2H, t), 3.78 (2H, q), 5.42 (1H, s), 7.01 (4H, m), 7.24 (2H, m), 7.58 (2H, d), 8.45 (1H, s). 
     Example 24: The Preparation of Compound II-8915 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.98 g (0.01 mol) 4,5-dichloro-6-(difluoromethyl)pyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to ethyl 2-chloro-4,4-difluoro-3-oxobutanoate) and 2.84 g (0.01 mol) 2-(4-(4-chlorophenoxy)phenyl)ethanamine hydrochloride in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 2.89 g compound II-8915 as white solid with yield of 70.5%, m.p. 98.5° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.94 (2H, t), 3.76-3.86 (2H, q), 5.71 (1H, s), 6.72 (1H, t), 6.90-7.05 (4H, m), 7.17-7.32 (4H, m), 8.57 (1H, s). 
     Example 25: The Preparation of Compound II-10583 
     
       
                 
         
             
             
         
      
     
     To a solution of 1.98 g (0.01 mol) 4,5-dichloro-6-(difluoromethyl)pyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to ethyl 2-chloro-4,4-difluoro-3-oxobutanoate) and 3.14 g (0.01 mol) 2-(4-(4-chlorophenoxy)-3-methoxyphenyl)ethanamine hydrochloride in 50 mL toluene was added 4.45 g (0.022 mol)triethylamine. The reaction mixture was continued stirring and heating to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, then the mixture was poured into (3×50 mL) of ethyl acetate to separate the organic layer, the organic phase was washed with 50 mL of brine, dried and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:2, as an eluent) to obtain 2.89 g compound II-10583 as rufous oil with yield of 76.8%. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.95 (2H, t), 3.80-3.92 (5H, m), 5.72 (1H, s), 6.72 (1H, t), 6.75-6.97 (5H, m), 7.20-7.26 (2H, m), 8.58 (1H, s). 
     Example 26: The Preparation of Compound II-19334 
     
       
                 
         
             
             
         
      
     
     To a solution of compound II-347 0.42 g (0.01 mol) in 20 mL ethanol was dropwise added 10 mL of concentrated hydrochloric acid at room temperature. The reaction mixture was heated to reflux for 4-10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive solvent was evaporated under reduced pressure, the brown residue was washed with (3×10 mL) of ethyl acetate to obtain 0.36 g compound II-19334 as white solid with yield of 78.1%, m.p. 120.5° C. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.27 (3H, t), 2.80-3.09 (4H, m), 3.80 (2H, d), 6.92-7.18 (4H, d), 7.31 (2H, d), 7.67 (2H, d), 8.71 (1H, d), 9.28 (1H, s). 
     Example 27: The Preparation of 2-(6-(4-chlorophenoxy)pyridin-3-yl)ethanamine 
     1) The Preparation of methyl 6-(4-chlorophenoxy)nicotinate 
     
       
                 
         
             
             
         
      
     
     To a solution of 25.6 g (0.2 mol) 4-chlorophenol in 350 mL N,N-dimethylformamide was added 70% sodium hydride 103 g (3.0 mol) in batches. The reaction mixture was stirred for 4 hours at room temperature, then 34.2 g (0.2 mol) methyl 6-chloronicotinate was added in batches, then the reaction temperature was raised to 100° C. to react for 10 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the solution was poured into water, extracted with ethyl acetate, the organic phase was washed with water, saturated brine successively, dried, filtered and evaporated under reduced pressure, the cooled residual was filtered and washed with petroleum ether, to obtain 42.0 g air dried target intermediate as brown solid, m.p. 64-66° C.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 3.92 (3H, s), 6.75 (1H, d), 6.96 (1H, d), 7.11 (2H, d), 7.37 (2H, d), 8.30 (1H, d), 8.81 (1H, s). 
     2) The Preparation of (6-(4-chlorophenoxy)pyridin-3-yl)methanol 
     
       
                 
         
             
             
         
      
     
     To a solution of 52.6 g (0.2 mol) methyl 6-(4-chlorophenoxy)nicotinate in 500 mL anhydrous ether was dropwise added 65% Red-Al 74.5 g (0.24 mol) in toluene at 0□. then the reaction mixture was stirred for 4 hours at room temperature, then at 0□, 10% sodium hydroxide solution prepared beforehand was dropwise added until the reaction solution was clarified, then the reaction temperature was raised to 35 □ to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the solution was poured into water, extracted with ethyl acetate, the organic phase was washed with water, saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 42.2 g target intermediate as white solid, m.p. 100-102° C.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 3.20 (1H, bs), 4.56 (2H, s), 6.87 (1H, d), 7.04 (2H, d), 7.33 (2H, d), 7.69 (1H, d), 8.06 (1H, s). 
     3) The Preparation of 5-(chloromethyl)-2-(4-chlorophenoxy)pyridine 
     
       
                 
         
             
             
         
      
     
     To a solution of 23.5 g (0.1 mol) (6-(4-chlorophenoxy)pyridin-3-yl)methanol in 350 mL dichloromethane was dropwise added 17.9 g (0.15 mol) sulfoxide chloride at 0° C. then the reaction mixture was stirred for 4 hours at room temperature, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the excessive sulfoxide chloride was evaporated and the residual was poured into water, extracted with ethyl acetate, the organic phase was washed with water, saturated sodium bicarbonate solution, and saturated brine successively, dried, filtered and evaporated under reduced pressure, to obtain 22.8 g target intermediate as white solid, m.p. 78-80° C.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 4.55 (2H, s), 6.94 (1H, d), 7.09 (2H, d), 7.36 (2H, d), 7.75 (1H, d), 8.15 (1H, s). 
     4) The Preparation of 2-(6-(4-chlorophenoxy)pyridin-3-yl)acetonitrile 
     
       
                 
         
             
             
         
      
     
     To a solution of 2.69 g (55 mmol) sodium cyanide dissolved in 300 mL dimethyl sulfoxide was added 13.9 g (50 mmol) 5-(chloromethyl)-2-(4-chlorophenoxy)pyridine and the catalytic amount of 18-Crown-6 at 40° C. then the reaction mixture was raised to 80° C. to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the residual was poured into water, extracted with toluene, the organic phase was washed with water, and saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:3, as an eluent) to obtain 11.2 g target intermediate as white solid, m.p. 100-102° C.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 3.70 (2H, s), 6.97 (1H, d), 7.08 (2H, d), 7.37 (2H, d), 7.71 (1H, d), 8.10 (1H, s). 
     5) The Preparation of 2-(6-(4-chlorophenoxy)pyridin-3-yl)ethanamine 
     
       
                 
         
             
             
         
      
     
     To a solution of 2-(6-(4-chlorophenoxy)pyridin-3-yl)acetonitrile 2.44 g (0.01 mol), Raney nickel (1.0 g) and 10 mL of 25% aqueous ammonia in 50 mL ethanol was filled with hydrogen, then the reaction mixture was continued stirring at room temperature for 3-15 hours and monitored by TLC until the reaction was over, Raney nickel was filtered, the solution was concentrated under reduced pressure to give 2.30 g jade-green sticky liquid with yield of 95.0%, colourless oil.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ(ppm): 1.46 (2H, bs), 2.70 (2H, t), 2.94 (2H, t), 6.87 (1H, d), 7.07 (2H, dd), 7.34 (2H, dd), 7.55 (1H, dd), 8.02 (1H, d). 
     Example 28: The Preparation of Compound III-7 
     
       
                 
         
             
             
         
      
     
     To a solution of 0.25 g (1.0 mmol) 2-(6-(4-chlorophenoxy)pyridin-3-yl)ethanamine and 0.21 g (1.5 mmol) potassium carbonate in 10 mL N,N-dimethylformamide was added 0.16 g (1.0 mmol) 4,5-dichloro-6-methylpyrimidine, then the reaction mixture was raised to 80° C. to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the residual was poured into water, extracted with ethyl acetate, the organic phase was washed with water, and saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 0.28 g compound III-7 as colourless oil.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.46 (3H, t), 2.91 (2H, t), 3.75 (2H, m), 5.43 (1H, bs), 6.89 (1H, d), 7.07 (2H, d), 7.35 (2H, d), 7.58 (1H, dd), 8.03 (1H, d), 8.39 (1H, s). 
     Example 29: The Preparation of Compound III-202 
     
       
                 
         
             
             
         
      
     
     To a solution of 0.28 g (1.0 mmol) 2-(6-(4-(trifluoromethyl)phenoxy)pyridin-3-yl)ethanamine (the preparation refers to Example 27, the difference is replacing 4-chlorophenol to 4-(trifluoromethyl)phenol) and 0.21 g (1.5 mmol) potassium carbonate in 10 mL N,N-dimethylformamide was added 0.18 g (1.0 mmol) 4,5-dichloro-6-ethylpyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to ethyl 2-chloro-3-oxopentanoate). then the reaction mixture was raised to 80° C. to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the residual was poured into water, extracted with ethyl acetate, the organic phase was washed with water, and saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 0.30 g compound III-202 as colourless oil. 
       1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 1.28 (3H, t), 2.78 (2H, m), 2.93 (2H, t), 3.76 (2H, m), 5.43 (1H, bs), 6.96 (1H, d), 7.20-7.23 (2H, m), 7.61-7.66 (3H, m), 8.06 (1H, d), 8.44 (1H, s). 
     Example 30: The Preparation of Compound III-622 
     
       
                 
         
             
             
         
      
     
     To a solution of 0.28 g (1.0 mmol) 2-(6-(2,4-dichlorophenoxy)pyridin-3-yl)ethanamine (the preparation refers to Example 27, the difference is replacing 4-chlorophenol to 2,4-dichlorophenol) and 0.21 g (1.5 mmol) potassium carbonate in 10 mL N,N-dimethylformamide was added 4,5-dichloro-6-(difluoromethyl)pyrimidine 0.20 g (1.0 mmol). then the reaction mixture was raised to 80° C. to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the residual was poured into water, extracted with ethyl acetate, the organic phase was washed with water, and saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 0.32 g compound III-622 as colourless oil.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.92 (2H, t), 3.80 (2H, m), 5.72 (1H, bs), 6.54, 6.72, 6.90 (1H, t), 6.89 (1H, s), 6.98 (1H, d), 7.14 (1H, d), 7.27-7.31 (2H, m), 7.48 (1H, d), 7.61 (1H, dd), 7.98 (1H, d), 8.56 (1H, s). 
     Example 31: The Preparation of Compound III-2630 
     
       
                 
         
             
             
         
      
     
     To a solution of 0.26 g (1.0 mmol) 2-(6-(4-chloro-2-methylphenoxy)pyridin-3-yl)ethanamine (the preparation refers to Example 27, the difference is replacing 4-chlorophenol to 4-chloro-2-methylphenol) and 0.21 g (1.5 mmol) potassium carbonate in 10 mL N,N-dimethylformamide was added 0.18 g (1.0 mmol) 4,5,6-trichloropyrimidine (the preparation refers to Example 1, the difference is replacing ethyl 2-chloro-3-oxobutanoate to diethyl 2-chloromalonate). then the reaction mixture was raised to 80° C. to react for 2 hours, and monitored by TLC (Thin-Layer Chromatography) until the reaction was over, the residual was poured into water, extracted with ethyl acetate, the organic phase was washed with water, and saturated brine successively, dried, filtered and evaporated under reduced pressure, the residual was purified via silica column (ethyl acetate/petroleum ether (boiling point range 60-90° C.)=1:4, as an eluent) to obtain 0.32 g compound III-2630 as colourless oil.  1 H-NMR (300 MHz, internal standard TMS, solvent CDCl 3 ) δ (ppm): 2.15 (3H, s), 2.89 (2H, t), 3.73-3.79 (2H, m), 5.62 (1H, bs), 6.87 (1H, d), 6.98 (1H, d), 7.18-7.22 (2H, m), 7.54 (1H, dd), 8.00 (1H, d), 8.29 (1H, s). 
     Other compounds represented by the general formula PY of the present invention were prepared according to the above examples. 
     Physical properties and  1 HNMR spectrum ( 1 HNMR, 300 MHz, internal standard: TMS, ppm) of some compounds of this invention are as follows: 
     Compound I-23: m.p. 147.5° C. δppm 2.46 (3H, s), 2.97 (2H, t), 3.78 (2H, q), 5.42 (1H, m), 7.01 (1H, d), 7.10 (2H, d), 7.30 (2H, d), 7.92 (1H, d), 8.40 (1H, s), 8.47 (1H, s). 
     Compound I-34: m.p. 109.0° C. δppm 2.46 (3H, s), 2.96 (2H, t), 3.79 (2H, q), 3.92 (3H, s), 5.43 (1H, m), 6.94 (1H, d), 7.12 (2H, d), 7.28 (2H, d), 8.28 (1H, d), 8.40 (1H, s), 8.82 (1H, s). 
     Compound I-35: yellow oil. δppm 1.38 (3H, t), 2.46 (3H, s), 2.96 (2H, t), 3.79 (2H, q), 4.38 (2H, q), 5.43 (1H, m), 6.93 (1H, d), 7.12 (2H, d), 7.28 (2H, d), 8.28 (1H, d), 8.40 (1H, s), 8.83 (1H, s). 
     Compound I-80: δppm 2.47 (3H, s), 2.95 (2H, t), 3.79 (2H, q), 5.55 (1H, m), 7.09 (1H, d), 7.18 (2H, m), 7.37 (1H, s), 7.93 (1H, m), 8.41 (2H, m). 
     Compound I-196: δppm 2.46 (3H, t), 2.96 (2H, t), 3.75 (3H, s), 3.80 (2H, dd), 5.49 (1H, t), 6.87 (2H, s), 7.02 (1H, d), 7.09 (1H, d), 7.88 (1H, d), 8.41 (2H, s). 
     Compound I-255: yellow oil. δppm 1.27 (3H, t), 2.79 (2H, q), 2.97 (2H, t), 3.80 (2H, q), 5.48 (1H, m), 7.02 (1H, d), 7.10 (2H, d), 7.30 (2H, d), 7.92 (1H, d), 8.46 (1H, s), 8.47 (1H, s). 
     Compound I-266: m.p. 102.2° C. δppm 1.26 (3H, t), 2.79 (2H, q), 2.97 (2H, t), 3.79 (2H, q), 3.92 (3H, s), 5.44 (1H, m), 6.94 (1H, d), 7.12 (2H, d), 8.29 (2H, d), 8.27 (1H, d), 8.45 (1H, s), 8.82 (1H, s). 
     Compound I-267: yellow oil. δppm 1.26 (3H, t), 1.38 (3H, t), 2.79 (2H, t), 2.98 (2H, t), 3.79 (2H, q), 4.38 (2H, q), 5.43 (1H, m), 6.93 (1H, d), 7.12 (2H, d), 7.29 (2H, d), 8.27 (1H, d), 8.45 (1H, s), 8.83 (1H, s). 
     Compound I-312: δppm 1.27 (3H, t), 2.80 (3H, q), 2.96 (2H, t), 3.80 (2H, q), 5.51 (1H, m), 7.09 (1H, d), 7.18 (2H, m), 7.37 (1H, s), 7.93 (1H, m), 8.40 (1H, s), 8.46 (1H, s). 
     Compound I-428: δppm 1.26 (3H, t), 2.79 (2H, dd), 2.96 (2H, t), 3.75 (3H, s), 3.81 (2H, dd), 5.50 (1H, t), 6.87 (2H, d), 7.02 (1H, d), 7.10 (1H, d), 7.88 (1H, s), 8.40 (1H, s), 8.45 (1H, s). 
     Compound I-467: m.p. 102-103° C. δppm 2.46 (3H, s), 2.96 (2H, t), 3.78 (2H, q), 5.43 (1H, s), 7.11 (2H, d), 7.27 (2H, d), 7.78 (1H, s), 7.97 (1H, s), 8.40 (1H, s). 
     Compound I-486: m.p. 92-93° C. δppm 2.47 (3H, s), 2.98 (2H, t), 3.80 (2H, q), 5.44 (1H, s), 7.13 (2H, d), 7.30 (2H, d), 7.98 (1H, s), 8.28 (1H, s), 8.41 (1H, s). 
     Compound I-502: m.p. 128.5° C. δppm 2.49 (3H, s), 2.89 (2H, t), 3.63 (2H, q), 5.34 (1H, m), 7.06 (2H, d), 7.28 (2H, d), 7.72 (2H, s), 8.24 (1H, s), 8.38 (1H, s), 8.46 (1H, s). 
     Compound I-602: colourless oil. Δppm 2.88 (2H, t), 4.06 (2H, q), 5.49 (s, 1H), 7.21 (4H, m,), 8.28 (1H, d), 8.28 (1H, s), 68.450 (1H, s). 
     Compound I-618: m.p. 168.9° C. δppm 1.26 (3H, t), 2.79 (2H, q), 2.97 (2H, t), 3.80 (2H, q), 5.47 (1H, m), 5.83 (2H, s), 7.13 (2H, d), 7.30 (2H, d), 8.28 (1H, s), 8.40 (1H, s), 8.44 (1H, s). 
     Compound I-699: m.p. 146-147° C. δppm 2.45 (3H, s), 2.96 (2H, t), 3.78 (2H, q), 5.45 (1H, s), 7.11 (2H, d), 7.28 (2H, d), 7.84 (1H, s), 8.41 (1H, s). 
     Compound I-815: m.p. 98-100° C. δppm 1.26 (3H, t), 2.79 (2H, q), 2.96 (2H, t), 3.79 (2H, q), 5.43 (1H, s), 7.11 (2H, d), 7.27 (2H, d), 7.84 (1H, s), 8.46 (1H, s). 
     Compound I-929: yellow oil. δppm 2.46 (3H, s), 2.96 (2H, t), 3.87 (2H, q), 5.47 (1H, m), 7.09 (1H, m), 7.14 (2H, d), 7.28 (2H, d), 7.98 (1H, d), 8.29 (1H, d), 8.40 (1H, s). 
     Compound I-987: yellow oil. δppm 1.26 (3H, t), 2.79 (2H, q), 2.96 (2H, t), 3.78 (2H, q), 5.46 (1H, m), 7.13 (1H, q), 7.15 (2H, d), 7.29 (2H, d), 8.00 (1H, d), 8.30 (1H, d), 8.45 (1H, s). 
     Compound I-1045: m.p. 80-83° C. δppm 1.39 (3H, t), 2.46 (3H, s), 2.94 (2H, t), 3.77 (2H, q), 5.47 (1H, s), 7.06 (1H, m), 7.12 (2H, d), 7.26 (2H, d), 8.27 (1H, m), 8.40 (1H, s). 
     Compound I-1199: m.p. 147-149° C. δppm 2.47 (3H, s), 2.97 (2H, t), 3.06 (3H, d), 3.62-3.79 (2H, q), 5.50 (1H, t), 7.12 (2H, d), 7.16 (1H, dd), 7.32 (2H, d), 7.86 (1H, s), 8.20 (1H, dd), 8.41 (1H, s), 8.64 (1H, dd). 
     Compound I-1219: m.p. 113-114° C. δppm 1.39 (3H, t), 2.79 (3H, s), 2.95 (2H, t), 3.78 (2H, q), 4.41 (2H, q), 5.49 (1H, t), 7.09 (3H, m), 7.27 (2H, m), 8.26 (2H, m), 8.45 (1H, s). 
     Compound I-1414: δppm 2.47 (3H, s), 2.96 (2H, t), 3.80 (2H, q), 5.46 (1H, m), 7.20 (2H, s), 7.37 (1H, s), 8.00 (1H, d), 8.24 (1H, d), 8.41 (1H, s). 
     Compound I-1472: δppm 1.27 (3H, t), 2.80 (2H, q), 2.97 (2H, t), 3.80 (2H, q), 5.47 (1H, m), 7.21 (2H, s), 7.37 (1H, s), 8.00 (1H, d), 8.25 (1H, d), 8.46 (1H, s). 
     Compound I-1646: δppm 2.46 (3H, t), 2.96 (2H, t), 3.74 (3H, s), 3.81 (2H, dd), 5.48 (1H, t), 6.89 (2H, t), 7.11 (1H, d), 7.96 (1H, d), 8.23 (1H, t), 8.41 (1H, s). 
     Compound I-1704: δppm 1.26 (3H, t), 2.79 (2H, dd), 2.96 (2H, t), 3.73 (3H, s), 3.79 (2H, dd), 5.48 (1H, t), 6.88 (2H, d), 7.12 (1H, d), 7.96 (1H, d), 8.23 (1H, s), 8.45 (1H, s). 
     Compound I-1762: δppm 2.50 (3H, s), 2.96 (2H, t), 3.78 (2H, q), 5.54 (1H, m), 7.01 (1H, d), 7.12 (1H, d), 7.30 (2H, d), 7.90 (1H, m), 8.41 (1H, s), 8.44 (1H, s). 
     Compound I-1820: δppm 1.26 (3H, t), 2.81 (3H, q), 2.97 (2H, t), 3.78 (2H, q), 5.55 (1H, m), 7.01 (1H, d), 7.11 (2H, d), 7.30 (2H, d), 7.90 (1H, m), 8.44 (1H, s). 
     Compound I-1878: δppm 2.50 (3H, s), 2.97 (2H, t), 3.79 (2H, q), 5.53 (1H, m), 7.14 (2H, d), 7.30 (3H, m), 7.99 (1H, s), 8.27 (1H, s), 8.40 (1H, s). 
     Compound I-1936: δppm 1.26 (3H, t), 2.81 (3H, q), 2.97 (2H, t), 3.79 (2H, q), 5.54 (1H, m), 7.13 (2H, d), 7.31 (2H, d), 7.98 (1H, m), 8.27 (1H, s), 8.44 (1H, s). 
     Compound I-2052: δppm 1.30 (3H, t), 2.83 (2H, q), 2.95 (2H, t), 3.79 (2H, q), 5.61 (1H, m), 7.09 (1H, d), 7.18 (2H, m), 7.33 (1H, s), 7.93 (1H, m), 8.43 (1H, d). 
     Compound I-2400: δppm 2.98 (3H, t), 3.85 (2H, q), 5.77 (1H, m), 6.73 (1H, m), 7.10 (1H, d), 7.19 (2H, m), 7.38 (1H, s), 7.94 (1H, m), 8.40 (1H, s), 8.59 (1H, s). 
     Compound I-2458: δppm 2.98 (2H, t), 3.75 (3H, s), 3.87 (2H, dd), 5.77 (1H, t), 6.72 (1H, t), 6.89 (2H, t), 7.03 (1H, d), 7.10 (1H, t), 7.88 (1H, dd), 8.40 (1H, s), 8.59 (1H, s). 
     Compound I-2555: brown oil. δppm 8.576 (s, 1H, pyrimidine-H), 7.965-7.972 (d, 1H, pyridine-6-H), 7.776-7.783 (d, 1H, pyridine-4-H), 7.128-7.294 (dd, 4H, Ar—H), 6.726-7.100 (t, 1H, F 2 C—H), 3.828-3.849 (q, 2H, N—CH 2 —C), 2.951-2.999 (t, 2H, C— CH 2 —Ar). 
     Compound I-2611: m.p. 156-157° C. δppm 8.583 (s, 1H, pyrimidine-H), 8.337-8.393 (m, 3H, pyridine-H), 7.164-7.322 (dd, 4H, Ar—H), 6.550-6.909 (t, 1H, F 2 C—H), 5.739 (s, 1H, NH), 3.816-3.883 (q, 2H, N—CH 2 —C), 2.968-3.015 (t, 2H, C—CH 2 —Ar). 
     Compound I-2690: δppm 2.98 (2H, t), 3.74 (3H, s), 3.86 (2H, dd), 5.76 (1H, t), 6.72 (1H, t), 6.88 (2H, d), 7.13 (1H, d), 7.96 (1H, d), 8.23 (1H, s), 8.58 (1H, s). 
     Compound I-2787: δppm 8.575 (s, 1H, pyrimidine-H), 7.965-7.972 (d, 1H, pyridine-6-H), 7.775-7.782 (d, 1H, pyridine-4-H), 7.105-7.295 (dd, 4H, Ar—H), 5.882 (s, 1H, NH), 3.815-3.881 (q, 2H, N—CH 2 —C), 2.955-3.001 (t, 2H, C—CH 2 —Ar). 
     Compound I-2843: m.p. 123-124° C. δppm 8.577 (s, 1H, pyrimidine-H), 8.336-8.394 (m, 3H, pyridine-H), 7.152-7.325 (dd, 4H, Ar—H), 5.917 (s, 1H, NH), 3.826-3.917 (q, 2H, N—CH 2 —C), 2.972-3.020 (t, 2H, C—CH 2 —Ar). 
     Compound I-3077: m.p. 130-132° C. δppm 2.46 (3H, s), 2.95 (2H, t), 3.77 (2H, q), 5.50 (1H, s), 7.16 (3H, m), 7.27 (2H, m), 7.48 (1H, d), 8.40 (1H, s). 
     Compound I-4121: δppm 2.50 (3H, s), 2.95 (2H, t), 3.77 (2H, q), 5.57 (1H, m), 7.16 (3H, m), 7.29 (2H, m), 7.49 (1H, d), 8.40 (1H, s). 
     Compound I-5221: m.p. 121-124° C. δppm 1.26 (3H, t), 2.78 (2H, q), 2.95 (2H, t), 3.78 (2H, m), 3.84 (6H, s), 5.44 (1H, s), 5.78 (1H, s), 7.20 (4H, m), 8.45 (1H, s). 
     Compound I-6729: m.p. 102.8° C. δppm 2.49 (3H, s), 2.88 (2H, t), 3.81 (2H, m), 7.11 (2H, d), 18 (1H, d), 7.30 (2H, d), 7.52 (1H, d), 8.17 (1H, d), 8.50 (1H, s), 8.78 (1H, s), 9.40 (1H, s). 
     Compound I-6731: m.p. 148.6° C. δppm 2.30 (3H, s), 2.49 (3H, s), 2.93 (2H, t), 3.81 (2H, m), 7.27-7.05 (8H, m), 7.29 (2H, d), 7.51 (1H, d), 8.14 (1H, d), 8.47 (1H, s), 8.77 (1H, s), 9.33 (1H, s). 
     Compound I-6732: m.p. 164.6° C. δppm 2.50 (3H, s), 2.94 (2H, t), 3.81 (2H, m), 7.09 (2H, d), 7.18 (1H, d), 7.30 (2H, d), 8.18 (1H, d), 8.50 (1H, s), 8.81 (1H, s), 9.28 (1H, s). 
     Compound I-6733: m.p. 113.7° C. δppm 2.35 (3H, s), 2.89 (2H, t), 3.64 (2H, m), 7.09 (2H, d), 7.16 (1H, d), 7.30 (2H, d), 7.37 (1H, m), 8.15 (1H, d), 8.19 (1H, s), 8.51 (1H, s). 
     Compound I-6734: m.p. 56.9° C. δppm 2.37 (3H, s), 2.90 (2H, t), 3.66 (2H, m), 7.09 (2H, d), 7.16 (1H, d), 7.29 (2H, d), 7.49 (1H, m), 8.16 (1H, d), 8.30 (1H, s), 8.50 (1H, s). 
     Compound I-6735: m.p.&gt;300° C. δppm 2.35 (3H, s), 2.88 (2H, t), 3.62 (2H, m), 7.08 (2H, d), 7.15 (1H, d), 7.36 (1H, m), 8.15 (1H, d), 7.32 (2H, d), 8.20 (1H, s), 8.48 (1H, s). 
     Compound I-6790: δppm 1.23 (3H, t), 2.51 (3H, s), 2.74 (2H, q), 2.94 (2H, t), 3.77 (2H, q), 5.40 (1H, m), 7.11 (2H, d), 7.26 (2H, d), 7.84 (1H, s). 
     Compound I-6791: yellow oil. δppm 1.23 (3H, t), 2.50 (3H, s), 2.74 (2H, q), 2.96 (2H, t), 3.79 (2H, q), 5.39 (1H, m), 5.83 (2H, s), 7.13 (2H, d), 7.30 (2H, d), 8.26 (1H, s), 8.40 (1H, s). 
     Compound I-6793: m.p. 116.0° C. δppm 1.23 (3H, t), 2.51 (3H, s), 2.74 (2H, q), 2.94 (2H, t), 3.77 (2H, q), 5.40 (1H, m), 7.10 (1H, m), 7.14 (2H, d), 7.29 (2H, d), 8.00 (1H, d), 8.31 (1H, d). 
     Compound I-6795: yellow oil. δppm 1.24 (3H, t), 2.46 (3H, s), 2.74 (2H, q), 2.96 (2H, t), 3.78 (2H, q), 5.40 (1H, m), 7.01 (1H, d), 7.10 (2H, d), 7.30 (2H, d), 7.91 (1H, d), 8.47 (1H, s). 
     Compound I-6796: m.p. 90.8° C. δppm 1.23 (3H, t), 1.38 (3H, t), 2.51 (3H, s), 2.74 (2H, q), 2.95 (2H, t), 3.78 (2H, q), 4.38 (2H, q), 5.38 (1H, m), 6.93 (1H, d), 7.11 (2H, d), 7.29 (2H, d), 8.28 (1H, d), 8.83 (1H, s). 
     Compound I-6797: yellow oil. δppm 1.23 (3H, t), 2.49 (3H, s), 2.74 (2H, q), 2.95 (2H, t), 3.78 (2H, q), 3.92 (3H, s), 5.39 (1H, m), 6.93 (1H, d), 7.11 (2H, d), 7.29 (2H, d), 8.28 (1H, d), 8.82 (1H, s). 
     Compound I-6806: δppm 1.24 (3H, t), 2.51 (3H, s), 2.75 (2H, q), 2.94 (2H, t), 3.79 (2H, q), 5.40 (1H, m), 7.09 (1H, d), 7.17 (2H, m), 7.33 (1H, s), 7.93 (1H, m), 8.41 (1H, s). 
     Compound II-19: δppm 2.52 (3H, s), 2.92 (2H, t), 3.75 (2H, dd), 5.43 (1H, t), 6.81-7.01 (4H, m), 7.19 (2H, d), 7.28 (2H, d), 8.39 (1H, s). 
     Compound II-21: δppm 2.46 (3H, s), 2.92 (2H, t), 3.75 (2H, dd), 5.42 (1H, t), 6.89 (1H, d), 6.92 (2H, d), 7.15-7.22 (3H, m), 7.47 (1H, d), 8.39 (1H, s). 
     Compound II-25: δppm 2.45 (3H, s), 2.95 (2H, t), 3.70-3.83 (2H, q), 5.44 (1H, t), 6.84 (2H, d), 7.00 (2H, d), 7.06 (1H, s), 7.26 (2H, d), 8.40 (1H, s). 
     Compound II-53: m.p. 140-142° C. δppm 2.65 (3H, s), 3.13 (2H, t), 3.65-3.76 (2H, q), 6.93 (1H, d), 7.17 (2H, d), 7.35 (2H, d), 8.31 (1H, d), 8.47 (1H, s), 8.62 (1H, t), 9.14 (1H, d). 
     Compound II-154: δppm 2.46 (3H, s), 2.95 (2H, t), 3.77 (2H, dd), 5.42 (1H, t), 6.92 (1H, d), 7.00 (2H, d), 7.25 (2H, d), 7.43 (1H, d), 7.75 (1H, s), 8.39 (1H, s). 
     Compound II-204: δppm 2.47 (3H, s), 2.96 (2H, t), 3.77 (2H, dd), 5.43 (1H, t), 6.93 (1H, t), 7.02 (2H, d), 7.26 (2H, d), 7.37 (1H, dd), 7.48 (1H, dd), 8.40 (1H, s). 
     Compound II-235: m.p. 140-142° C. δppm 1.25 (3H, s), 2.45 (3H, s), 2.86 (2H, t), 3.72 (2H, q), 5.41 (1H, s), 6.79 (2H, d), 7.08 (2H, d), 8.39 (2H, m). 
     Compound II-236: δppm 2.25 (3H, s), 2.45 (3H, s), 2.90 (2H, t), 3.62-3.81 (2H, q), 5.43 (1H, t), 6.74 (2H, d), 7.14 (2H, d), 7.40 (1H, d), 7.77 (1H, d), 8.38 (1H, s). 
     Compound II-254: m.p. 183-185° C. δppm 2.45 (3H, s), 2.86 (2H, t), 3.66-3.83 (2H, q), 5.43 (1H, t), 6.80 (2H, d), 7.08 (2H, d), 8.39 (1H, s). 
     Compound II-274: m.p. 130-132° C. δppm 2.929-2.953 (t, 2H), 3.744-3.765 (q, 2H), 5.65 (s, 1H), 6.830-7.230 (dd, 4H), 8.392 (s, 1H). 
     Compound II-299: δppm 1.23 (3H, t), 2.78 (2H, dd), 2.92 (2H, t), 3.75 (2H, dd), 5.44 (1H, t), 6.85 (1H, d), 6.91 (2H, d), 7.17-7.23 (3H, m), 7.46 (1H, d), 8.44 (1H, s). 
     Compound II-432: δppm 1.26 (3H, t), 2.78 (2H, dd), 2.95 (2H, t), 3.77 (2H, dd), 5.44 (1H, t), 6.92 (1H, d), 7.00 (2H, d), 7.25 (2H, d), 7.42 (1H, d), 7.73 (1H, s), 8.44 (1H, s). 
     Compound II-443: m.p. 101.0° C. δppm 1.25 (3H, t), 2.77 (2H, dd), 2.92 (2H, t), 3.74 (2H, dd), 5.42 (1H, t), 6.79 (2H, d), 7.18 (2H, d), 8.32 (2H, s), 8.43 (1H, s). 
     Compound II-482: δppm 1.26 (3H, t), 2.78 (2H, dd), 2.98 (2H, t), 3.78 (2H, dd), 5.44 (1H, t), 6.93 (1H, t), 7.08 (2H, d), 7.27 (2H, d), 7.37 (1H, dd), 7.48 (1H, dd), 8.44 (1H, s). 
     Compound II-1687: δppm 2.46 (3H, s), 2.93 (2H, t), 3.75-3.96 (5H, m), 5.43 (1H, t), 6.77-6.87 (4H, m), 6.93 (1H, d), 7.23 (2H, d), 8.40 (1H, s). 
     Compound II-1737: δppm 2.47 (3H, s), 2.95 (2H, t), 3.75-3.91 (5H, m), 5.42 (1H, t), 6.80-7.04 (5H, m), 7.53 (2H, d), 8.41 (1H, s). 
     Compound II-1965: δppm 1.26 (3H, t), 2.79 (2H, dd), 2.95 (2H, t), 3.72-3.95 (5H, m), 5.45 (1H, t), 6.78-6.90 (4H, m), 6.94 (1H, d), 7.24 (2H, d), 8.45 (1H, s). 
     Compound II-2015: δppm 1.26 (3H, t), 2.79 (2H, dd), 2.95 (2H, t), 3.75-3.95 (5H, m), 5.48 (1H, t), 6.80-6.88 (2H, q), 6.93 (2H, d), 7.01 (1H, d), 7.53 (2H, d), 8.45 (1H, s). 
     Compound II-8917: m.p. 93.3° C. δppm 2.94 (2H, t), 3.81 (2H, dd), 5.70 (1H, t), 6.72 (1H, t), 6.90-6.97 (3H, q), 7.16-7.23 (3H, q), 7.47 (1H, d), 8.57 (1H, s). 
     Compound II-8921: m.p. 106-107° C. δppm 2.945-2.992 (2H, t), 3.797-3.864 (2H, q), 5.717 (1H, s), 6.549-6.848 (1H, t), 6.854-7.237 (7H, m), 8.583 (1H, s). 
     Compound II-8965: m.p. 109-110° C. δppm 2.944-2.990 (2H, t), 3.798-3.865 (2H, q), 5.717 (1H, s), 6.542-6.900 (1H, t), 7.010-7.588 (8H, m), 8.574 (1H, s). 
     Compound II-9058: δppm 2.938-2.984 (2H, t), 3.790-3.858 (2H, q), 6.545-6.903 (1H, t), 6.992-7.458 (4H, dd), 6.930-6.959 (1H, d), 7.478-7.487 (1H, d), 7.952-7.960 (1H, s), 8.571 (1H, s). 
     Compound II-9073: m.p. 77-78° C. δppm 2.970-3.016 (2H, t), 3.812-3.878 (2H, q), 5.738 (1H, s), 6.549-6.906 (1H, t), 7.061-7.319 (4H, dd), 7.005-7.035 (1H, d), 7.698-7.727 (1H, d), 8.233 (1H, s), 8.575 (1H, s). 
     Compound             II-9170: m.p. 154-158° C. δppm 2.951-2.975 (2H, t), 3.800-3.821 (2H, q), 6.714-6.874 (1H, t), 6.844-7.233 (4H, dd), 8.569 (1H, s).
     Compound II-9336: m.p. 130-131° C. δppm 2.942-2.989 (2H, t), 3.799-3.866 (2H, q), 6.994-7.459 (4H, dd), 6.936-6.965 (1H, d), 7.480-7.488 (1H, d), 7.593-7.961 (1H, d), 8.571 (1H, s). 
     Compound II-9351: m.p. 128-129° C. δppm 2.975-3.021 (2H, t), 3.820-3.887 (2H, q), 5.875 (1H, s), 7.066-7.322 (4H, dd), 7.009-7.039 (1H, d), 7.704-7.731 (1H, d), 8.238 (1H, s), 8.580 (1H, s). 
     Compound II-10633: δppm 2.98 (2H, t), 3.79 (3H, t), 3.86 (2H, dd) 5.74 (1H, s), 6.72 (1H, t), 6.84-7.05 (5H, m), 7.53 (2H, d), 8.58 (1H, s). 
     Compound III-1: colourless oil. δppm 2.50 (3H, s), 2.88 (2H, t), 3.74 (2H, m), 5.45 (1H, bs), 6.87 (1H, d), 7.09-7.22 (3H, m), 7.36-7.42 (2H, m), 7.56 (1H, dd), 8.05 (1H, d), 8.38 (1H, s). 
     Compound III-5: colourless oil. 
     Compound III-6: colourless oil. δppm 2.46 (3H, s), 2.92 (2H, t), 3.75 (2H, m), 5.42 (1H, bs), 6.90 (1H, d), 7.03 (1H, dd), 7.13-7.18 (2H, m), 7.29 (1H, d), 7.59 (1H, dd), 8.05 (1H, d), 8.39 (1H, s). 
     Compound III-16: colourless oil. δppm 2.35 (3H, s), 2.52 (3H, s), 2.88 (2H, t), 3.70-3.77 (2H, m), 5.42 (1H, bs), 6.85 (1H, d), 7.01 (2H, d), 7.19 (2H, d), 7.53 (1H, dd), 8.03 (1H, d), 8.38 (1H, s). 
     Compound III-19: colourless oil. δppm 2.46 (3H, s), 2.89 (2H, t), 3.70-3.77 (2H, m), 3.82 (3H, s), 5.42 (1H, bs), 6.83 (1H, d), 6.92 (2H, d), 7.06 (2H, d), 7.53 (1H, dd), 8.03 (1H, d), 8.38 (1H, s). 
     Compound III-21: colourless oil. 
     Compound III-22: colourless oil. δppm 2.46 (3H, t), 2.93 (2H, t), 3.76 (2H, m), 5.43 (1H, bs), 6.95 (1H, d), 7.20-7.28 (2H, m), 7.60-7.66 (3H, m), 8.06 (1H, d), 8.39 (1H, s). 
     Compound III-82: colourless oil. δppm 2.46 (3H, s), 2.90 (2H, t), 3.74 (2H, m), 5.42 (1H, bs), 6.97 (1H, d), 7.14 (1H, d), 7.28 (1H, d), 7.49 (1H, d), 7.62 (1H, dd), 7.97 (1H, d), 8.38 (1H, s). 
     Compound III-83: colourless oil. δppm 2.46 (3H, s), 2.91 (2H, t), 3.75 (2H, m), 5.42 (1H, bs), 6.97 (1H, d), 7.16 (1H, dd), 7.22 (1H, d), 7.40 (1H, d), 7.61 (1H, dd), 7.99 (1H, d), 8.39 (1H, s). 
     Compound III-110: colourless oil. δppm 2.14 (3H, t), 2.46 (3H, t), 2.89 (2H, t), 3.73 (2H, m), 5.42 (1H, bs), 6.86 (1H, d), 6.97 (1H, d), 7.17-7.25 (2H, m), 7.56 (1H, dd), 7.99 (1H, d), 8.38 (1H, s). 
     Compound III-121: colourless oil. 
     Compound III-181: colourless oil. δppm 1.26 (3H, t), 2.78 (2H, m), 2.90 (2H, t), 3.75 (2H, m), 5.45 (1H, bs), 6.87 (1H, d), 7.11-7.22 (3H, m), 7.36-7.42 (2H, m), 7.56 (1H, dd), 8.05 (1H, d), 8.43 (1H, s). 
     Compound III-185: colourless oil. δppm 1.26 (3H, t), 2.78 (2H, m), 2.88 (2H, t), 3.74 (2H, m), 5.43 (1H, bs), 6.94 (1H, d), 7.20 (2H, d), 7.28-7.32 (1H, m), 7.47 (1H, d), 7.59 (1H, dd), 8.00 (1H, d), 8.43 (1H, s). 
     Compound III-186: colourless oil. δppm 1.26 (3H, t), 2.75-2.83 (2H, m), 2.89-2.96 (2H, m), 3.72-3.79 (2H, m), 5.47 (1H, bs), 6.91 (1H, d), 7.03 (1H, d), 7.13-7.19 (2H, m), 7.29-7.34 (1H, m), 7.60 (1H, dd), 8.06 (1H, s), 8.44 (1H, s). 
     Compound III-187: colourless oil. δppm 1.26 (3H, t), 2.79 (2H, m), 2.91 (2H, t), 3.75 (2H, m), 5.43 (1H, bs), 6.89 (1H, d), 7.07 (2H, d), 7.35 (2H, d), 7.58 (1H, dd), 8.03 (1H, dd), 8.43 (1H, s). 
     Compound III-196: colourless oil. δppm 1.23 (3H, t), 2.35 (3H, s), 2.74-2.91 (5H, m), 3.70-3.77 (2H, m), 5.46 (1H, bs), 6.85 (1H, d), 6.99 (2H, d), 7.19 (2H, d), 7.54 (1H, dd), 8.03 (1H, d), 8.43 (1H, s). 
     Compound III-199: colourless oil. δppm 1.26 (3H, t), 2.75-2.82 (2H, m), 2.88 (2H, t), 3.70-3.77 (2H, m), 3.82 (3H, s), 5.42 (1H, bs), 6.83 (1H, d), 6.92 (2H, d), 7.06 (2H, d), 7.54 (1H, dd), 8.03 (1H, d), 8.43 (1H, s). 
     Compound III-201: colourless oil. 
     Compound III-262: colourless oil. δppm 1.26 (3H, t), 2.79 (2H, m), 2.90 (2H, t), 3.74 (2H, m), 5.42 (1H, bs), 6.97 (1H, d), 7.14 (1H, d), 7.29 (1H, d), 7.48 (1H, d), 7.61 (1H, dd), 7.97 (1H, d), 8.43 (1H, s). 
     Compound III-263: colourless oil. δppm 1.26 (3H, t), 2.81 (2H, m), 2.91 (2H, t), 3.75 (2H, m), 5.43 (1H, bs), 6.98 (1H, d), 7.14-7.22 (2H, m), 7.40 (2H, d), 7.63 (1H, dd), 7.99 (1H, s), 8.44 (1H, s). 
     Compound III-290: colourless oil. δppm 1.26 (3H, t), 2.14 (3H, s), 2.78 (2H, m), 2.89 (2H, t), 3.74 (2H, m), 5.42 (1H, bs), 6.86 (1H, d), 6.97 (1H, d), 7.19 (1H, dd), 7.25 (1H, d), 7.57 (1H, dd), 8.00 (1H, d), 8.43 (1H, s). 
     Compound III-301: colourless oil. 
     Compound III-541: colourless oil. δppm 2.91 (2H, t), 3.81 (2H, m), 5.73 (1H, bs), 6.54, 6.71, 6.83 (1H, t), 6.88 (1H, d), 7.09-7.18 (2H, m), 7.22 (1H, t), 7.36-7.42 (2H, m), 7.56 (1H, dd), 8.07 (1H, d), 8.56 (1H, s). 
     Compound III-545: colourless oil. δppm 2.92 (2H, t), 3.80 (2H, m), 5.71 (1H, bs), 6.53, 6.71, 6.89 (1H, t), 6.95 (1H, d), 7.18-7.32 (3H, m), 7.47 (1H, d), 7.59 (1H, dd), 8.00 (1H, d), 8.56 (1H, s). 
     Compound III-546: colourless oil. δppm 2.94 (2H, t), 3.77-3.82 (2H, m), 5.74 (1H, bs), 6.54, 6.72, 6.89 (1H, t), 6.91 (1H, d), 7.02 (1H, d), 7.13-7.18 (2H, m), 7.29-7.35 (1H, m), 7.61 (1H, dd), 8.06 (1H, d), 8.61 (1H, s). 
     Compound III-547: colourless oil. δppm 2.93 (2H, t), 3.80 (2H, m), 5.72 (1H, bs), 6.53, 6.72, 6.89 (1H, t), 6.92 (1H, d), 7.07 (2H, d), 7.35 (2H, d), 7.58 (1H, dd), 8.03 (1H, s), 8.56 (1H, s). 
     Compound III-556: colourless oil. δppm 2.35 (3H, t), 2.91 (2H, t), 3.76-3.84 (2H, m), 5.73 (1H, bs), 6.54, 6.72, 6.84 (1H, t), 6.89 (1H, d), 7.01 (1H, d), 7.19 (1H, d), 7.55 (1H, dd), 8.04 (1H, d), 8.56 (1H, s). 
     Compound III-559: colourless oil. δppm 2.91 (2H, t), 3.76-3.81 (5H, m), 5.73 (1H, bs), 6.54, 6.72, 6.84 (1H, t), 6.91 (1H, d), 6.94 (1H, dd), 7.06 (1H, dd), 7.54 (1H, dd), 8.03 (1H, d), 8.56 (1H, s). 
     Compound III-561: colourless oil. δppm 2.95 (2H, t), 3.81 (2H, m), 5.74 (1H, bs), 6.54, 6.72, 6.89 (1H, t), 6.95 (1H, d), 7.32 (1H, d), 7.39 (1H, s), 7.44-7.54 (2H, m), 7.62 (1H, dd), 8.05 (1H, d), 8.57 (1H, s). 
     Compound III-562: colourless oil. δppm 2.95 (2H, t), 3.81 (2H, m), 5.74 (1H, bs), 6.54, 6.72, 6.89 (1H, t), 6.97 (1H, d), 7.21-7.24 (2H, m), 7.61-7.67 (3H, m), 8.06 (1H, d), 8.57 (1H, s). 
     Compound III-623: colourless oil. δppm 2.92 (2H, t), 3.80 (2H, m), 5.72 (1H, bs), 6.54, 6.72, 6.89 (1H, t), 6.91 (1H, s), 6.99 (1H, d), 7.15-7.22 (2H, m), 7.40 (1H, d), 7.61 (1H, dd), 8.00 (1H, d), 8.57 (1H, s). 
     Compound III-650: colourless oil. δppm 2.13 (3H, s), 2.91 (2H, t), 3.79 (2H, m), 5.66 (1H, bs), 6.53, 6.72, 6.86 (1H, t), 6.89 (1H, s), 6.97 (1H, d), 7.17-7.25 (2H, m), 7.57 (1H, dd), 8.01 (1H, d), 8.56 (1H, s). 
     Compound III-661: colourless oil. 
     Compound III-2521: colourless oil. δppm 2.90 (2H, t), 3.74-3.81 (2H, m), 5.60 (1H, bs), 6.83-6.89 (1H, m), 7.09-7.11 (2H, m), 7.13-7.22 (1H, m), 7.37-7.42 (2H, m), 7.49-7.56 (1H, m), 8.15 (1H, d), 8.29 (1H, s). 
     Compound III-2526: colourless oil. δppm 2.92 (2H, t), 3.74-3.81 (2H, m), 5.62 (1H, bs), 6.91 (1H, d), 7.02 (1H, d), 7.14-7.18 (2H, m), 7.29-7.34 (1H, m), 7.57-7.60 (1H, m), 8.05 (1H, d), 8.32 (1H, s). 
     Compound III-2527: colourless oil. δppm 2.91 (2H, t), 3.74-3.81 (2H, m), 5.60 (1H, bs), 6.90 (1H, d), 7.07 (2H, dd), 7.35 (2H, dd), 7.54 (1H, dd), 8.03 (1H, d), 8.29 (1H, s). 
     Compound III-2536: colourless oil. δ(CDCl 3 ): 2.36 (3H, s), 2.89 (2H, t), 3.73-3.79 (2H, m), 5.62 (1H, bs), 6.85 (1H, d), 6.98-7.02 (2H, m), 7.20 (2H, d), 7.54 (1H, dd), 8.03 (1H, d), 8.29 (1H, s). 
     Compound III-2539: colourless oil. δppm 2.89 (2H, t), 3.73-3.79 (2H, m), 3.81 (3H, t), 5.61 (1H, bs), 6.83 (1H, d), 6.92 (2H, dd), 7.05 (2H, dd), 7.52 (1H, dd), 8.03 (1H, d), 8.29 (1H, s). 
     Compound III-2541: colourless oil. δppm 2.93 (2H, t), 3.75-3.82 (2H, m), 5.62 (1H, bs), 6.94 (1H, d), 7.32 (1H, d), 7.40-7.51 (3H, m), 7.60 (1H, dd), 8.04 (1H, d), 8.30 (1H, s). 
     Biological Testing 
     The compounds of the present invention exhibit both excellent fungicidal activity against many fungi in agricultural field and better insecticidal and acaricidal activities. 
     Except for the controls CK1-CK21 (known compounds illustrated in background technology) listed in following Table 303-310, according to the prior art, the following compounds CK22-CK84, diflumetorim and flufenerim were also prepared as controls, all the controls were self-made, they are listed in Table 302. 
     
       
         
               
             
               
               
             
           
               
                 TABLE 302 
               
             
             
               
                   
               
               
                 the structure of controls 
               
             
          
           
               
                 No. 
                 Structure 
               
               
                   
               
               
                 CK22 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK23 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK24 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK25 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK26 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK27 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK28 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK29 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK30 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK31 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK32 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK33 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK34 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK35 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK36 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK37 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK38 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK39 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK40 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK41 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK42 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK43 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK44 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK45 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK46 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK47 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK48 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK49 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK50 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK51 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK52 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK53 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK54 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK55 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK56 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK57 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK58 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK59 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK60 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK61 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK62 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK63 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK64 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK65 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK66 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK67 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK68 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK69 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK70 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK71 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK72 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK73 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK74 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK75 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK76 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK77 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK78 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK79 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK80 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK81 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK82 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK83 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 CK84 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
     Example 32: Fungicidal Testing 
     (1) The Determination of Protectant Activity In Vivo 
     The method is as followed: The whole plant is used in this test. The compound is dissolved in a proper solvent to get mother solution. The proper solvent is selected from acetone, methanol, DMF and so on according to their dissolving capability to the sample. The volume rate of solvent and testing solution (v/v) is equal to or less than 5%. The mother solution is diluted with water containing 0.1% tween-80 to get the testing solution whose concentration is designed. The testing solution is sprayed to the host plant by a special plant sprayer. The plant is inoculated with fungus after 24 hours. According to the infecting characteristic of fungus, the plant is stored in a humidity chamber and then transferred into greenhouse after infection is finished. And the other plants are placed in greenhouse directly. The activity of compound is obtained by eyeballing after 7 days in common. 
     The protectant activities in vivo of some compounds are as follows: 
     The protectant activity against cucumber downy mildew in vivo: 
     At the dosage of 400 ppm, the protectant activity of compounds I-22, I-35, I-254, I-255, I-467, I-483, I-486, I-502, I-583, I-602, I-699, I-815, I-987, I-1762, I-1878, I-2555, I-2574, I-2748, I-2611, I-3077, I-3309, I-4757, I-5221, I-6730, I-6732, I-6740, I-6765, I-6790, I-6796, II-21, II-25, II-69, II-154, II-204, II-236, II-254, II-297, II-299, II-303, II-347, II-432, II-482, II-1687, II-1965, II-8915, II-8917, II-8921, II-8965, II-9058, II-10583, III-1, III-5, III-7, III-16, III-19, III-22, III-82, III-110, III-121, III-181, III-187, III-196, III-199, III-201, II-202, III-262, III-263, III-290, III-301, III-541, III-547, III-556, III-562, III-622, III-623, III-650, III-2521, III-2526, III-2527, III-2536, III-2539, III-2541, III-2630 and so on was 100%, the protectant activity of compounds I-618, I-1199, I-2787, I-2843, I-6793, I-6797, II-235, II-274, II-9073, II-9170, II-9336, II-19334 and so on was between 80%-99%; 
     At the dosage of 100 ppm, the protectant activity of compounds I-22, I-254, I-255, I-467, I-583, I-602, I-699, I-987, I-1199, I-2748, I-3077, I-4757, I-6730, I-6732, I-6740, I-6765, II-21, II-204, II-236, II-297, II-299, II-482, II-1687, II-8915, II-8917, II-8921, II-8965, II-10583, III-1, III-5, III-7, III-16, III-19, III-22, III-82, III-110, III-121, III-181, III-187, III-196, III-199, III-201, III-202, III-262, III-263, III-301, III-541, III-547, III-556, III-562, III-622, III-623, III-650, III-2521, III-2526, III-2527, III-2536, III-2539, III-2541 and so on was 100%, the protectant activity of compounds I-35, I-502, I-987, I-2555, I-2611, I-3309, I-5221, I-6790, I-6796, II-25, II-69, II-303, II-347, II-9058, III-290, III-2630 and so on was between 80%-99%; 
     At the dosage of 50 ppm, the protectant activity of compounds I-22, I-254, I-255, I-467, I-2748, I-3077, I-6730, I-6765, II-21, II-204, II-236, II-297, II-482, II-1687, II-8917, II-8965, III-1, III-5, III-7, III-16, III-19, III-22, III-82, III-110, III-121, III-181, III-187, III-196, III-201, III-202, III-262, III-263, III-301, III-541, III-547, III-556, III-562, III-622, III-623, III-650, III-2521, III-2526, III-2527, III-2536, III-2539, III-2541 and so on was 100%, the protectant activity of compounds I-583, I-602, I-699, I-987, I-1199, I-2611, I-3309, I-5221, I-6790, I-6796, II-25, II-299, II-8915, II-8921, II-9058, II-10583, III-199, III-2630 and so on was between 80%-99%; 
     At the dosage of 25 ppm, the protectant activity of compounds I-22, I-255, I-467, I-583, I-699, I-3077, I-6730, I-6732, I-6765, II-204, II-236, II-297, II-482, II-8917, III-1, III-5, III-7, III-16, III-19, III-22, III-82, III-110, III-121, III-181, III-187, III-196, III-201, III-202, III-262, III-263, III-301, III-541, III-547, III-556, III-562, III-622, III-623, III-2521, III-2526, III-2527, III-2539 and so on was 100%, the protectant activity of compounds I-602, I-699, I-3309, I-6790, II-25, II-1687, II-8915, II-8921, II-8965, II-10583, III-199, III-650, III-2536, III-2541 and so on was between 80%-99%; 
     At the dosage of 12.5 ppm, the protectant activity of compounds I-22, III-1, III-7, III-16, III-22, III-187, III-202, III-301, III-541, III-556, III-562, III-622, III-2521, III-2527 and so on was 100%, the protectant activity of compounds I-255, I-3077, I-6765, II-204, II-482, II-8915, II-8917, II-10583, III-19, III-82, III-196, III-201, III-263, III-623, III-650, III-2536, III-2539 and so on was between 80%-99%; 
     At the dosage of 6.25 ppm, the protectant activity of compounds I-22, III-7, III-16, III-22, III-187, III-202, III-301, III-541, III-562 and so on was 100%, the protectant activity of compounds I-6765, II-8915, II-8917, II-10583, III-19, III-196, III-556, III-622 and so on was between 80%-99%. 
     The protectant activity against wheat powdery mildew in vivo: 
     At the dosage of 400 ppm, the protectant activity of compounds I-22, I-23, I-34, I-35, I-254, I-255, I-266, I-267, I-467, I-486, I-502, I-602, I-815, I-929, I-987, I-1219, I-1414, I-1472, I-1762, I-2342, I-2555, I-2574, I-3309, I-4121, I-4757, I-6729, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6790, I-6793, I-6795, I-6796, II-19, II-25, II-69, II-154, II-204, II-297, II-299, II-303, II-347, II-432, II-482, II-1687, II-1965, II-8917, II-8921, II-8965, II-9058, II-9073, II-10583, II-19334, III-1, III-5, III-6, III-7, III-16, III-19, III-21, III-22, III-82, III-83, III-110, III-121, III-181, III-185, III-186, III-187, III-196, III-199, III-201, III-202, III-262, III-263, III-301, III-541, III-545, III-546, III-547, III-556, III-559, III-561, III-562, III-622, III-623, III-650, III-2536, III-2541 and so on was 100%; compounds I-483, I-583, I-2748, I-2787, I-2922, I-3077, I-5221, I-6797, II-53, II-9351, III-2539 and so on was between 80%-99%. 
     At the dosage of 100 ppm, the protectant activity of compounds I-22, I-254, I-255, I-267, I-467, I-486, I-602, I-987, I-1414, I-1472, I-2342, I-2555, I-2574, I-6729, I-6730, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6793, II-154, II-204, II-297, II-303, II-347, II-432, II-482, II-1687, II-8921, II-8965, II-10583, II-19334, III-121, III-202, III-301 and so on was 100%; compounds I-23, I-483, I-502, I-583, I-6731, I-6732, I-6733, I-6735, II-19, II-25, II-299, II-8917, II-9058, II-9073, III-1, III-5, III-7, III-22, III-82, III-110, III-181, III-541, III-545, III-562, III-2541 and so on was between 80%-99%. 
     At the dosage of 25 ppm, the protectant activity of compounds I-22, I-254, I-255, I-2342, I-2555, I-2574, I-6730, I-6739, I-6740, I-6742, I-6765, I-6793, II-204, II-297, II-303, II-347, II-432, II-482, II-1687, II-8921, II-10583, II-19334, III-202 and so on was 100%; compounds I-23, I-254, I-502, I-602, I-987, I-6729, I-6731, I-6732, I-6733, I-6735, I-6756, I-6763, II-19, II-299, II-8917, II-8965, II-9058, II-9073, III-121, III-301 and so on was between 80%-99%. 
     At the dosage of 6.25 ppm, the protectant activity of compounds I-22, I-2342, I-2574, I-6765, II-204, II-432, II-10583 and II-19334 and so on was 100%; compounds I-23, I-255, I-502, I-2555, I-6730, I-6739, I-6742, II-19, II-297, II-303, II-482, II-1687, II-8921, III-202 and so on was between 80%-99%. 
     The protectant activity against corn rust in vivo: 
     At the dosage of 400 ppm, the protectant activity of compounds I-22, I-35, I-254, I-266, I-267, I-467, I-483, I-486, I-583, I-815, I-929, I-987, I-1045, I-1199, I-1219, I-1472, I-1762, I-1878, I-2342, I-2555, I-2574, I-2922, I-3077, I-4121, I-4757, I-5221, I-6729, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6790, I-6791, I-6793, I-6795, I-6796, II-19, II-21, II-53, II-69, II-154, II-165, II-204, II-297, II-299, II-303, II-347, II-432, II-482, II-1687, II-1965, II-8915, II-8917, II-8921, II-8965, II-10583, II-19334, III-1, III-6, III-7, III-16, III-19, III-21, III-82, III-83, III-110, III-181, III-185, III-186, III-196, III-199, III-201, III-202, III-262, III-301, III-541, III-545, III-546, III-547, III-556, III-559, III-561, III-622, III-623, III-661, III-2521, III-2526, III-2536, III-2539, III-2630 and so on was 100%; compounds I-1627, I-2748, II-25, II-236, II-254, III-5, III-22, III-650, III-2527, III-2541 and so on was between 80%-99%. 
     At the dosage of 100 ppm, the protectant activity of compounds I-22, I-35, I-254, I-467, I-486, I-583, I-987, I-2342, I-2574, I-2922, I-4757, I-5221, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6796, II-21, II-69, II-154, II-204, II-297, II-299, II-303, II-347, II-432, II-482, II-1687, II-8915, II-8917, II-8965, II-10583, III-6, III-7, III-21, III-110, III-201, III-202, III-262, III-301, III-545, III-546, III-559, III-561, III-622, III-661 and so on was 100%; compounds I-267, I-815, I-1199, I-1219, I-3077, I-3309, I-6730, I-6791, II-19, II-165, II-8921, II-19334, III-19, III-82, III-181, III-185, III-186, III-196, III-199, III-547, III-556, III-623, III-2526 and so on was between 80%-99%. 
     At the dosage of 25 ppm, the protectant activity of compounds I-22, I-254, I-583, I-2342, I-6729, I-6742, II-69, II-154, II-204, II-303, II-432, II-482, II-8915, II-8917, II-8965, III-7, III-262, III-561, III-622 and so on was 100%; compounds I-35, I-266, I-467, I-987, I-1219, I-2574, I-4757, I-5221, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6765, I-6757, I-6796, II-21, II-297, II-299, II-347, II-8921, II-10583, III-199, III-201, III-545, III-546, III-559 was between 80%-99%. 
     At the dosage of 6.25 ppm, the protectant activity of compounds I-22, I-254, I-2342, I-6742, II-154, II-303, II-432, II-482, II-8915, II-8917 and so on was 100%; compounds I-266, I-987, I-2574, I-6732, I-6733, I-6796, II-21, II-204, II-297, II-299, II-347, II-8921, II-8965, III-262, III-559, III-561, III-622 was between 80%-99%. 
     (2) Determination of Fungicidal Activity In Vitro 
     The method is as followed: High Through Put is used in the test. The compound is dissolved in a proper solvent to become a testing solution whose concentration is designed. The solvent is selected from acetone, methanol, DMF and so on according to their dissolving capability to the sample. In a no animalcule condition, the testing solution and pathogens suspension are added into the cells of 96 cells culture board, which then should be placed in the constant temperature box. 24 hours later, pathogen germination or growth can be investigated by eyeballing, and the activity in vitro of the compound is evaluated based on germination or growth of control treatment. 
     The activities in vitro (inhibition rate) of some compounds are as follows: 
     The inhibition rate against rice blast: 
     At the dosage of 25 ppm, the inhibition rate of compounds I-22, I-483, I-929, I-987, I-1762, I-2574, I-2922, I-6757, I-6758, I-6763, II-53, II-165, II-274, II-1965, III-7, III-121, III-301, III-661 and so on was 100%; compounds I-23, I-35, I-254, I-255, I-266, I-618, I-1199, I-1219, I-1878, I-2342, I-3077, I-3309, I-4121, I-4757, I-5221, I-6729, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6742, I-6758, I-6791, I-6793, I-6795, I-6796, I-6797, II-19, II-25, II-69, II-204, II-347, II-482, II-1687, II-9336, II-10583, III-1, III-5, III-6, III-7, III-16, III-19, III-21, III-22, III-82, III-83, III-110, III-181, III-186, III-187, III-196, III-199, III-201, III-202, III-262, III-541, III-545, III-546, III-547, III-556, III-559, III-561, III-562, III-622, III-623, III-661, III-2521, III-2526, III-2536, III-2539, III-2541, III-2630 was between 80%-99%, contrast compounds CK4, CK5, CK6, CK10, CK20, CK32, CK33, CK35, CK37, CK40, CK41, CK43, CK46, CK47, CK48, CK49, CK50, CK55, CK56 and CK58 was less than 50%, contrast compounds CK1, CK2, CK3, CK7, CK11, CK13, CK15, CK16, CK21, CK38, CK39, CK44, CK45, CK59, CK60, CK61 and CK63 was all 0; 
     At the dosage of 8.3 ppm, the inhibition rate of compounds I-483, I-2574, I-2922, II-53, II-165, III-7, III-661 and so on was 100%; compounds I-22, I-929, I-987, I-6758 and II-274 was between 80%-99%, contrast compound CK17 was 50%; contrast compounds CK5, CK6, CK14, CK18, CK19, CK46, CK47, CK48, CK49, CK50, CK51, CK52 and diflumetorim was all 0; 
     At the dosage of 2.8 ppm, the inhibition rate of compounds I-483, I-2922, II-53, II-165, III-7 and so on was 100%; compound II-274 was between 80%-99%, contrast compound CK17 was 0; 
     At the dosage of 0.9 ppm, the inhibition rate of compounds I-483, I-2922, II-53, II-165, III-7 and so on was 100%; 
     At the dosage of 0.3 ppm, the inhibition rate of compounds I-483, I-2922, II-53, II-165 and III-7 was 100%; 
     At the dosage of 0.1 ppm, the inhibition rate of compounds I-483, I-2922, II-165 and III-7 was 100%; 
     The inhibition rate against cucumber gray mold: 
     At the dosage of 25 ppm, the inhibition rate of compounds I-486, I-1045, I-2342, I-4757, II-303, II-1965, II-8921, III-82 and so on was 100%; compounds I-1199, I-3309, II-69, II-347, III-7, III-199, III-202, III-262, III-545, III-547, III-559, III-622 was between 80%-99%, contrast compounds CK20, CK21, CK24, CK25, CK44, CK45, CK56, CK57, CK62 was less than 50%, contrast compounds CK1, CK2, CK3, CK4, CK6, CK7, CK8, CK9, CK10, CK13, CK14, CK15, CK16, CK17, CK22, CK26, CK32, CK33, CK34, CK35, CK46, CK47, CK48, CK51, CK52, CK53, CK54, CK55, CK58, CK59, CK60, CK61, CK63, CK67, CK68, CK70, CK73, CK74, CK75, CK76, CK77, CK78, CK79, CK80, CK81, CK82, CK83, CK84, diflumetorim and flufenerim was all 0; 
     (2) The Contrastive Test Results of Some Compounds and Contrasts 
     Contrastive tests were carried out between some compounds and contrasts. The test results are listed in table 303-table 305 (“///” in the following tables means no test). 
     
       
         
               
             
               
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 303 
               
             
             
               
                   
               
               
                 The comparative test of protectant activity against cucumber  
               
               
                 downy mildew 
               
             
          
           
               
                   
                 control effect against cucumber downy mildew (%) 
               
             
          
           
               
                 Compound 
                 400  
                 100  
                 50  
                 25  
                 12.5  
                 6.25  
                 3.125  
               
               
                 No. 
                 mg/L 
                 mg/L 
                 mg/L 
                 mg/L 
                 mg/L 
                 mg/L 
                 mg/L 
               
               
                   
               
             
          
           
               
                 I-22 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 85 
               
               
                 I-3309 
                 100 
                 90 
                 90 
                 90 
                 70 
                 60 
                 50 
               
               
                 II-236 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-297 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-8915 
                 100 
                 100 
                 100 
                 99 
                 95 
                 90 
                 20 
               
               
                 II-8917 
                 100 
                 100 
                 100 
                 100 
                 95 
                 85 
                 /// 
               
               
                 II-10583 
                 100 
                 100 
                 100 
                 95 
                 95 
                 95 
                 /// 
               
               
                 III-1 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 III-5 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-7 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 III-16 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-19 
                 100 
                 100 
                 100 
                 100 
                 98 
                 95 
                 /// 
               
               
                 III-22 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-82 
                 100 
                 100 
                 100 
                 100 
                 98 
                 /// 
                 /// 
               
               
                 III-110 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-121 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-181 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-187 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-196 
                 100 
                 100 
                 100 
                 100 
                 85 
                 85 
                 /// 
               
               
                 III-201 
                 100 
                 100 
                 100 
                 100 
                 98 
                 /// 
                 /// 
               
               
                 III-202 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-262  
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-263 
                 100 
                 100 
                 100 
                 100 
                 98 
                 70 
                 /// 
               
               
                 III-301 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-541 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 95 
               
               
                 III-547 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-556 
                 100 
                 100 
                 100 
                 100 
                 100 
                 95 
                 /// 
               
               
                 III-562 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
               
               
                 III-622 
                 100 
                 100 
                 100 
                 100 
                 100 
                 98 
                 /// 
               
               
                 III-623 
                 100 
                 100 
                 100 
                 100 
                 98 
                 70 
                 /// 
               
               
                 III-650  
                 100 
                 100 
                 100 
                 98 
                 95 
                 /// 
                 /// 
               
               
                 III-2521 
                 100 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 III-2527 
                 100 
                 100 
                 100 
                 100 
                 100 
                 75 
                 /// 
               
               
                 III-2536 
                 100 
                 100 
                 100 
                 98 
                 90 
                 /// 
                 /// 
               
               
                 III-2539 
                 100 
                 100 
                 100 
                 100 
                 85 
                 /// 
                 /// 
               
               
                 CK1 
                 100 
                 100 
                 100 
                 100 
                 50 
                 30 
                 20 
               
               
                 CK3 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK6 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK7 
                 70 
                 30 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK8 
                 98 
                 95 
                 80 
                 75 
                 /// 
                 /// 
                 /// 
               
               
                 CK9 
                 100 
                 98 
                 90 
                 70 
                 /// 
                 /// 
                 /// 
               
               
                 CK10 
                 100 
                 82 
                 40 
                 20 
                 /// 
                 /// 
                 /// 
               
               
                 CK11 
                 85 
                 30 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK13 
                 85 
                 25 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK14 
                 98 
                 40 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK15 
                 95 
                 15 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK16 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK17 
                 100 
                 40 
                 10 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK20 
                 100 
                 10 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK22 
                 100 
                 98 
                 75 
                 60 
                 /// 
                 /// 
                 /// 
               
               
                 CK23 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK25 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK26 
                 100 
                 60 
                 40 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK27 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK28 
                 100 
                 40 
                 20 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK29 
                 98 
                 98 
                 90 
                 25 
                 /// 
                 /// 
                 /// 
               
               
                 CK32 
                 60 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK33 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK34 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK35 
                 60 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK37 
                 100 
                 20 
                 10 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK42 
                 100 
                 100 
                 100 
                 20 
                 0 
                 0 
                 0 
               
               
                 CK43 
                 100 
                 40 
                 20 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK52 
                 100 
                 98 
                 90 
                 70 
                 /// 
                 /// 
                 /// 
               
               
                 CK53 
                 100 
                 90 
                 85 
                 60 
                 /// 
                 /// 
                 /// 
               
               
                 CK54 
                 100 
                 90 
                 80 
                 65 
                 /// 
                 /// 
                 /// 
               
               
                 CK55 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK56 
                 100 
                 10 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK57 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK58 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK59 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK60 
                 100 
                 10 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK61 
                 100 
                 90 
                 85 
                 30 
                 /// 
                 /// 
                 /// 
               
               
                 CK62 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK63 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK65 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK66 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK67 
                 100 
                 60 
                 20 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK68 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK69 
                 100 
                 100 
                 98 
                 50 
                 /// 
                 /// 
                 /// 
               
               
                 CK70 
                 100 
                 60 
                 30 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK71 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK72 
                 100 
                 100 
                 40 
                 20 
                 /// 
                 /// 
                 /// 
               
               
                 CK73 
                 98 
                 98 
                 95 
                 60 
                 /// 
                 /// 
                 /// 
               
               
                 CK74 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK75 
                 60 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK76 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK77 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK78 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK79 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK80 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK83 
                 100 
                 100 
                 98 
                 85 
                 /// 
                 /// 
                 /// 
               
               
                 CK84 
                 100 
                 100 
                 100 
                 85 
                 /// 
                 /// 
                 /// 
               
               
                 diflumetorim 
                 100 
                 100 
                 100 
                 70 
                 15 
                 0 
                 /// 
               
               
                 flufenerim 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 304 
               
             
             
               
                   
               
               
                 The comparative test of protectant activity against wheat  
               
               
                 powdery mildew 
               
             
          
           
               
                   
                 control effect against wheat powdery mildew (%) 
               
             
          
           
               
                 Compound  
                 400  
                 100  
                 25  
                 6.25  
                 1.6  
                 0.4  
               
               
                 No. 
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L 
                 mg/L  
                 mg/L 
               
               
                   
               
             
          
           
               
                 I-22 
                 100 
                 100 
                 100 
                 100 
                 15 
                 /// 
               
               
                 I-254 
                 100 
                 100 
                 100 
                 100 
                 20 
                 /// 
               
               
                 I-2342 
                 100 
                 100 
                 100 
                 100 
                 95 
                 60 
               
               
                 I-2574 
                 100 
                 100 
                 100 
                 100 
                 75 
                 20 
               
               
                 I-6765 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 II-204 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 II-297 
                 100 
                 100 
                 100 
                 90 
                 40 
                 30 
               
               
                 II-303 
                 100 
                 100 
                 100 
                 90 
                 80 
                 25 
               
               
                 II-432 
                 100 
                 100 
                 100 
                 100 
                 80 
                 50 
               
               
                 II-482 
                 100 
                 100 
                 100 
                 98 
                 /// 
                 /// 
               
               
                 II-8921 
                 100 
                 100 
                 100 
                 90 
                 40 
                 /// 
               
               
                 II-10583 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 II-19334 
                 100 
                 100 
                 100 
                 100 
                 60 
                 /// 
               
               
                 III-1 
                 100 
                 98 
                 98 
                 98 
                 /// 
                 /// 
               
               
                 III-202  
                 100 
                 100 
                 100 
                 95 
                 /// 
                 /// 
               
               
                 CK1 
                 100 
                 100 
                 100 
                 80 
                 /// 
                 /// 
               
               
                 CK2 
                 100 
                 100 
                 80 
                 0 
                 /// 
                 /// 
               
               
                 CK4 
                 40 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK6 
                 100 
                 100 
                 90 
                 85 
                 0 
                 0 
               
               
                 CK8 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK9 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK10 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK11 
                 100 
                 60 
                 40 
                 0 
                 /// 
                 /// 
               
               
                 CK12 
                 80 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK13 
                 40 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK14 
                 85 
                 10 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK15 
                 95 
                 85 
                 10 
                 0 
                 /// 
                 /// 
               
               
                 CK16 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK17 
                 100 
                 75 
                 70 
                 50 
                 /// 
                 /// 
               
               
                 CK19 
                 50 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK20 
                 100 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK21 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK22 
                 100 
                 90 
                 50 
                 0 
                 /// 
                 /// 
               
               
                 CK23 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK24 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK25 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK26 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK27 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK29 
                 100 
                 80 
                 50 
                 40 
                 /// 
                 /// 
               
               
                 CK30 
                 100 
                 80 
                 20 
                 0 
                 /// 
                 /// 
               
               
                 CK31 
                 0 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK32 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK33 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK34 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK35 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK36 
                 100 
                 80 
                 60 
                 0 
                 /// 
                 /// 
               
               
                 CK37 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK41 
                 100 
                 70 
                 50 
                 0 
                 /// 
                 /// 
               
               
                 CK42 
                 100 
                 70 
                 60 
                 50 
                 /// 
                 /// 
               
               
                 CK43 
                 20 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK44 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK45 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK48 
                 30 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK51 
                 100 
                 80 
                 40 
                 0 
                 /// 
                 /// 
               
               
                 CK53 
                 100 
                 80 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK52 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK55 
                 60 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK56 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK57 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK58 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK59 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK60 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK61 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK63 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK65 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK66 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK67 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK68 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK69 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK70 
                 98 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK71 
                 100 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK72 
                 100 
                 70 
                 60 
                 50 
                 /// 
                 /// 
               
               
                 CK73 
                 40 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK74 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK75 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK76 
                 75 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK77 
                 100 
                 100 
                 80 
                 70 
                 /// 
                 /// 
               
               
                 CK78 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK79 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK80 
                 100 
                 80 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK81 
                 40 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK82 
                 100 
                 80 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK83 
                 100 
                 100 
                 70 
                 40 
                 /// 
                 /// 
               
               
                 diflumetorim 
                 100 
                 95 
                 95 
                 90 
                 /// 
                 /// 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 305 
               
             
             
               
                   
               
               
                 The comparative test of protectant activity against corn rust 
               
             
          
           
               
                   
                 control effect against corn rust (%) 
               
             
          
           
               
                 Compound 
                 400 
                 100 
                 25 
                 6.25 
                 1.6 
                 0.4 
               
               
                 No. 
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L 
                 mg/L 
               
               
                   
               
             
          
           
               
                 I-22 
                 100 
                 100 
                 100 
                 100 
                 50 
                 20 
               
               
                 I-254 
                 100 
                 100 
                 100 
                 100 
                 95 
                 40 
               
               
                 II-154 
                 100 
                 100 
                 100 
                 100 
                 50 
                 /// 
               
               
                 II-303 
                 100 
                 100 
                 100 
                 100 
                 80 
                 50 
               
               
                 II-432 
                 100 
                 100 
                 100 
                 100 
                 75 
                 15 
               
               
                 II-482 
                 100 
                 100 
                 100 
                 100 
                 /// 
                 /// 
               
               
                 II-8915 
                 100 
                 100 
                 100 
                 100 
                 80 
                 30 
               
               
                 II-8917 
                 100 
                 100 
                 100 
                 100 
                 60 
                 10 
               
               
                 II-8965 
                 100 
                 100 
                 100 
                 95 
                 85 
                 30 
               
               
                 III-7 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-262 
                 100 
                 100 
                 100 
                 90 
                 90 
                 60 
               
               
                 III-561 
                 100 
                 100 
                 100 
                 95 
                 80 
                 40 
               
               
                 CK2 
                 100 
                 100 
                 100 
                 85 
                 /// 
                 /// 
               
               
                 CK4 
                 0  
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK5 
                 95 
                 98 
                 40 
                 30 
                 /// 
                 /// 
               
               
                 CK6 
                 100 
                 100 
                 100 
                 80 
                 30  
                 0 
               
               
                 CK8 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK9 
                 100 
                 100 
                 20 
                 0 
                 /// 
                 /// 
               
               
                 CK10 
                 50 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK12 
                 100 
                 100 
                 85 
                 75 
                 /// 
                 /// 
               
               
                 CK13 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK14 
                 100 
                 20 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK15 
                 95  
                 85 
                 30 
                 0 
                 /// 
                 /// 
               
               
                 CK16 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK17 
                 100 
                 0 
                 0 
                 0 
                 //// 
                 /// 
               
               
                 CK18 
                 80 
                 30 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK19 
                 70 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK20 
                 100 
                 70 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK21 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK22 
                 100 
                 100 
                 40 
                 0 
                 /// 
                 /// 
               
               
                 CK23 
                 100 
                 0 
                 0  
                 0 
                 /// 
                 /// 
               
               
                 CK24 
                 100 
                 50 
                 20  
                 0 
                 /// 
                 /// 
               
               
                 CK25 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK26 
                 100 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK27 
                 100 
                 100 
                 90 
                 30 
                 /// 
                 /// 
               
               
                 CK28 
                 100 
                 100 
                 100 
                 95 
                 0 
                 0 
               
               
                 CK29 
                 100 
                 95 
                 85 
                 30 
                 /// 
                 /// 
               
               
                 CK30 
                 0 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK31 
                 0  
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK33 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK34 
                 0  
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK35 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK36 
                 100 
                 60 
                 40 
                 0 
                 /// 
                 /// 
               
               
                 CK37 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK38  
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK39 
                 100 
                 100 
                 80 
                 50 
                 10  
                 0 
               
               
                 CK40 
                 100 
                 100 
                 90 
                 70 
                 30  
                 0 
               
               
                 CK41 
                 100 
                 100 
                 90 
                 80 
                 20  
                 0 
               
               
                 CK42 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK43 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK44 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK45 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK46 
                 40 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK47 
                 80 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK48 
                 60  
                 20 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK49 
                 85 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK50 
                 80 
                 0 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK51 
                 80 
                 20 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK52 
                 85 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK53 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK54 
                 100 
                 60 
                 30 
                 0 
                 /// 
                 /// 
               
               
                 CK55 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK56 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK57 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK58 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK59 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK60 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK61 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK63 
                 100 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK65 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK66 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK67 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK68 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK69 
                 100 
                 90 
                 50 
                 0 
                 /// 
                 /// 
               
               
                 CK70 
                 100 
                 30 
                 10 
                 0 
                 /// 
                 /// 
               
               
                 CK71 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK72 
                 100 
                 80 
                 20 
                 0 
                 /// 
                 /// 
               
               
                 CK73 
                 100 
                 90 
                 10 
                 0 
                 /// 
                 /// 
               
               
                 CK74 
                 100 
                 100 
                 90 
                 85 
                 /// 
                 /// 
               
               
                 CK75 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK76 
                 70 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK77 
                 100 
                 60 
                 40 
                 0 
                 /// 
                 /// 
               
               
                 CK78 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK79 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK80 
                 100 
                 85 
                 20 
                 0 
                 /// 
                 /// 
               
               
                 CK81 
                 80 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK82 
                 100 
                 30 
                 0 
                 0 
                 /// 
                 /// 
               
               
                 CK83 
                 30 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK84 
                 100 
                 90 
                 60 
                 0 
                 /// 
                 /// 
               
               
                 diflumetorim 
                 100 
                 80 
                 10 
                 0 
                 /// 
                 /// 
               
               
                   
               
             
          
         
       
     
     Example 33: Bioactivity Test Against Insects and Mites 
     Determination of insecticidal activity of compounds of the present invention against a few insects were carried out by the following procedures: 
     Compounds were dissolved in mixed solvent (acetone:methanol=1:1), and diluted to required concentration with water containing 0.1% of tween 80. 
     Diamond back moth, armyworm, peach aphid and carmine spider mite were used as targets and the method of spraying by airbrush was used for determination of insecticidal biassays. 
     (1) Bioactivity Test Against Diamond Back Moth 
     (1) Determination of Insecticidal Activity Against Diamond Back Moth 
     The method of spraying by airbrush: The cabbage leaves were made into plates of 2 cm diameter by use of punch. A test solution (0.5 ml) was sprayed by airbrush at the pressure of 0.7 kg/cm 2  to both sides of every plate. 10 Second instar larvae were put into the petri-dishes after the leaf disc air-dried and 3 replicates were set for each treatment. Then the insects were maintained in observation room (25° C., 60˜70% R.H.). Scores were conducted and mortalities were calculated after 72 hrs. 
     Part of Test Results Against Diamond Back Moth: 
     At the dosage of 600 ppm, compounds I-22, I-254, I-255, I-467, I-583, I-815, I-3077, I-3309, I-4121, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6742, I-6756, I-6757, I-6758, I-6765, II-19, II-154, II-204, II-297, II-347, II-482, II-1687, II-1965, II-8915, II-8965, II-10583, II-19334, III-1, III-6, III-7, III-16, III-19, III-21, III-22, III-110, III-181, III-185, III-187, III-196, III-199, III-201, III-202, III-541, III-546, III-547, II-556, III-559, III-562, III-622 and III-2527 showed 100% control against carmine spider mite; compounds II-21, II-274, II-303, II-432, II-8917, II-9170, III-83, III-262, III-545, II-561, III-2526 and III-2539 showed 80%-99% control. 
     At the dosage of 100 ppm, compounds I-254, I-255, I-6739, I-6740, I-6742, I-6756, I-6757, I-6758, I-6765, I-3309, II-19, II-204, II-482, II-19334, III-196, III-546, III-547 and III-556 showed 100% control against carmine spider mite; compounds II-1965, II-8965, II-9170, III-7, III-22, III-187 and III-202 showed 80%-99% control. 
     (2) Bioactivity Test Against Armyworm 
     The method of spraying by airbrush: The corn leaves were made into plates of 2 cm diameter by use of punch. A test solution (0.5 ml) was sprayed by airbrush at the pressure of 0.7 kg/cm 2  to both sides of every plate. 10 Second instar larvae were put into the petri-dishes after the leaf disc air-dried and 3 replicates were set for each treatment. Then the insects were maintained in observation room (25□, 60˜70% R.H.). Scores were conducted and mortalities were calculated after 72 h. 
     Part of Test Results Against Armyworm: 
     At the dosage of 600 ppm, compounds I-255, I-467, I-486, I-583, I-1472, I-2342, I-3309, I-4121, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6756, I-6757, I-6758, I-6763, I-6765, II-19, II-21, II-69, II-204, II-297, II-299, II-347, II-482, II-1965, II-8915, II-8917, II-8965, II-10583, II-19334, III-1, III-6, III-7, III-16, III-19, III-21, III-22, III-181, III-187, III-196, III-199, III-201, III-202, III-541, III-546, III-547, III-556, II-559, III-561, III-562 and III-2527 showed 100% control against carmine spider mite; compounds I-254, I-1762, I-2748, I-6742, II-303, II-432, III-110, III-650 and III-2541 showed 80%-99% control. 
     At the dosage of 100 ppm, compounds I-255, I-3309, I-6739, I-6740, I-6741, I-6756, I-6757, I-6758, I-6763, I-6765, II-204, II-482, II-8965, III-22, III-187, III-199, III-202, III-547, III-559, III-561 and III-562 showed 100% control against carmine spider mite; compounds I-1472, II-69, II-297, II-1965, II-8915, II-19334, III-196, III-201 and III-650 showed 80%-99% control. 
     At the dosage of 10 ppm, compounds II-482, III-187, III-547 and III-562 showed 80%-99% control. 
     (3) Bioactivity Test Against Green Peach Aphid 
     Method: Filter papers were put in culture dishes (Diameter=6 cm), and water was dripped on filter papers for preserving moisture. Green peach aphids ( Myzus Persicae  Sulzer) were maintained on cabbage. Leaves (Diameter=3 cm) of approximately 15-30 aphids were put in the culture dishes. Bioactivity tests were used the method of Airbrush Foliar Spray, pressure=10 psi (0.7 kg/cm2), spray volume=0.5 mL. The studies were conducted at three constant temperatures 25±1 C in incubator cabinets with 60±5% RH. Survey the survival aphids after 48 hrs and calculate the death rates. 
     Part of Test Results Against Green Peach Aphid: 
     At the dosage of 600 ppm, compounds I-22, I-23, I-34, I-35, I-254, I-255, I-266, I-267, I-467, I-483, I-486, I-502, I-583, I-602, I-815, I-929, I-987, I-1414, I-1472, I-1762, I-1878, I-2342, I-2555, I-2748, I-3077, I-3309, I-4121, I-6729, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6790, I-6793, I-6795, I-6796, I-6797, II-19, II-21, II-25, II-69, II-154, II-204, II-236, II-297, II-299, II-303, II-347, II-432, II-443, II-482, II-1687, II-1965, II-8915, II-8917, II-8921, II-8965, II-9073, II-10583, II-19334, III-1, III-5, III-6, III-7, III-16, III-19, III-21, III-22, III-82, III-83, III-110, III-121, III-181, III-185, III-186, III-187, III-196, III-199, III-201, III-202, III-262, III-263, III-301, III-541, III-545, III-546, III-547, III-556, III-559, III-561, III-562, III-622, III-623, III-650, III-661, III-2527, III-2536 and III-2539 showed 100% control against carmine spider mite; compounds I-699, I-1199, I-5221, III-2526 and III-2541 showed 80%-99% control. 
     At the dosage of 100 ppm, compounds I-22, I-23, I-34, I-35, I-254, I-255, I-266, I-267, I-483, I-486, I-583, I-602, I-815, I-987, I-1414, I-1472, I-1762, I-1878, I-2342, I-2555, I-3077, I-3309, I-4121, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6793, I-6796, I-6797, II-19, II-69, II-154, II-204, II-297, II-299, II-303, II-347, II-432, II-443, II-482, II-1687, II-1965, II-8915, II-8917, II-8965, II-10583, II-19334, III-7, III-16, III-22, III-110, III-121, III-181, III-185, III-186, III-187, III-196, III-199, III-201, III-202, III-262, III-301, III-541, III-547, III-556, III-559, III-561, III-562, III-650 and III-661 showed 100% control against carmine spider mite; compounds I-467, I-5221, II-21, II-25, II-8921, II-9073, III-1, III-5, III-6, III-21, III-545 and III-546 showed 80%-99% control. 
     At the dosage of 10 ppm, compounds I-22, I-34, I-35, I-254, I-255, I-266, I-267, I-987, I-1472, I-1762, I-1878, I-2342, I-3309, I-4121, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6796, II-19, II-69, II-204, II-297, II-347, II-482, II-1687, II-1965, II-8915, II-8917, II-8965, II-10583, II-19334, III-22, III-181, III-187, III-202, III-301, III-547 and III-562 showed 100% control against carmine spider mite; compounds I-23, I-583, I-602, I-3077, I-6793, I-6797, II-21, II-299, III-7, III-186, III-196 and III-541 showed 80%-99% control. 
     At the dosage of 5 ppm, compounds I-254, I-1762, I-6731, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, II-69, II-204, II-297, II-347, II-482 and II-8915 showed 100% control against carmine spider mite; compounds II-299, II-8917, II-8965 and II-19334 showed 80%-99% control. 
     At the dosage of 2.5 ppm, compounds I-254, I-6739, I-6756, I-6757, I-6758, I-6765, II-297, II-347, II-482 and II-8915 showed 100% control against carmine spider mite; compounds II-69, II-204 and II-19334 showed 80%-99% control. 
     (4) Bioactivity Test Against Carmine Spider Mite 
     The method: Broadbean shoots with two true leaves in pot were taken, the healthy adults of carmine spider mite were inoculated to the leaves. The adults were counted and then sprayed with airbrush at the pressure of 0.7 kg/cm 2  and at dose of 0.5 ml. 3 replicates were set for each treatment. And then they were maintained in standard observation room. Scores were conducted and mortalities were calculated after 72 hrs. 
     Parts of the Test Results Against Carmine Spider Mite are as Follows: 
     At the dosage of 600 ppm, compounds I-22, I-23, I-254, I-255, I-266, I-267, I-483, I-583, I-602, I-929, I-987, I-1472, I-1762, I-2342, I-6729, I-6730, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6742, I-6756, I-6757, I-6758, I-6763, I-6765, I-6795, I-6797, II-19, II-21, II-69, II-154, II-204, II-297, II-299, II-303, II-347, II-432, II-443, II-482, II-1687, II-1965, II-8915, II-8917, II-8965, II-10583, II-19334, III-1, III-5, III-7, III-16, III-19, III-21, III-22, III-110, III-181, III-185, III-187, III-196, III-199, III-201, III-202, III-541, III-545, III-547, III-556, III-559, III-561, III-562 and III-2539 showed 100% control against carmine spider mite; compounds I-1414, I-2555, I-3077, I-3309, I-6796, II-165, III-83, III-546 and III-623 showed 80%-99% control. 
     At the dosage of 100 ppm, compounds I-22, I-254, I-255, I-266, I-987, I-1762, I-2342, I-6729, I-6731, I-6732, I-6733, I-6734, I-6735, I-6739, I-6740, I-6741, I-6756, I-6757, I-6758, I-6763, I-6765, I-6795, I-6797, II-19, II-21, II-69, II-154, II-204, II-297, II-299, II-347, II-432, II-443, II-482, II-1965, II-8915, II-8917, II-8965, II-19334, III-7, III-16, III-22, III-181, III-187, III-199, III-202, III-547, III-556, III-559 and III-562 showed 100% control against carmine spider mite; compounds I-23, I-483, I-602, I-3309, III-1, III-19, III-196, III-541 and III-2539 showed 80%-99% control. 
     At the dosage of 10 ppm, compounds I-254, I-6739, I-6756, I-6765, II-204, II-347, II-482, II-8965 and II-19334 showed 100% control against carmine spider mite; compounds I-6740, I-6741, I-6757, I-6758, II-69, II-443, III-199 and III-562 showed 80%-99% control. 
     At the dosage of 5 ppm, compounds II-482 and II-19334 showed 100% control against carmine spider mite; compounds II-204, II-347 and II-8965 showed 80%-99% control. 
     At the dosage of 2.5 ppm, compounds II-482, II-8965 and II-19334 showed 80%-99% control. 
     (5) The Contrastive Test Results of Some Compounds and Contrasts 
     Contrastive tests were carried out between some compounds and contrasts. The test results are listed in table 306 to table 310 (“///” in the following tables means no test). 
     
       
         
               
             
               
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 306 
               
             
             
               
                   
               
               
                 contrastive tests against diamond back moth 
               
             
          
           
               
                   
                 Insecticidal activity against 
               
               
                   
                 diamond back moth (%) 
               
             
          
           
               
                   
                 Compound No. 
                 600 mg/L 
                 100 mg/L 
                 10 mg/L 
               
               
                   
                   
               
             
          
           
               
                   
                 I-255 
                 100 
                 100 
                 43 
               
               
                   
                 I-3309 
                 100 
                 100 
                 60 
               
               
                   
                 I-6733 
                 100 
                 68 
                 40 
               
               
                   
                 I-6734 
                 100 
                 52 
                 40 
               
               
                   
                 I-6742 
                 100 
                 75 
                 47 
               
               
                   
                 II-19 
                 100 
                 100 
                 50 
               
               
                   
                 II-204 
                 100 
                 100 
                 20 
               
               
                   
                 II-347 
                 100 
                 70 
                 65 
               
               
                   
                 II-482 
                 100 
                 100 
                 60 
               
               
                   
                 II-8965 
                 100 
                 80 
                 40 
               
               
                   
                 III-196 
                 100 
                 100 
                 /// 
               
               
                   
                 III-546 
                 100 
                 100 
                 /// 
               
               
                   
                 III-547 
                 100 
                 100 
                 57 
               
               
                   
                 III-556 
                 100 
                 100 
                 77 
               
               
                   
                 CK4 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK6 
                 86 
                 16 
                 0 
               
               
                   
                 CK7 
                 85 
                 16 
                 0 
               
               
                   
                 CK8 
                 33 
                 /// 
                 /// 
               
               
                   
                 CK9 
                 100 
                 45 
                 25 
               
               
                   
                 CK10 
                 33 
                 /// 
                 /// 
               
               
                   
                 CK11 
                 86 
                 55 
                 5 
               
               
                   
                 CK12 
                 100 
                 35 
                 0 
               
               
                   
                 CK13 
                 67 
                 16 
                 0 
               
               
                   
                 CK14 
                 67 
                 10 
                 0 
               
               
                   
                 CK15 
                 17 
                 15 
                 0 
               
               
                   
                 CK16 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK17 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK20 
                 57 
                 /// 
                 /// 
               
               
                   
                 CK21 
                 80 
                 25 
                 10 
               
               
                   
                 CK22 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK23 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK25 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK26 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK27 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK28 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK29 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK30 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK32 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK33 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK34 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK35 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK36 
                 20 
                 0 
                 0 
               
               
                   
                 CK37 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK38 
                 100 
                 21 
                 5 
               
               
                   
                 CK39 
                 80 
                 20 
                 0 
               
               
                   
                 CK40 
                 100 
                 29 
                 13 
               
               
                   
                 CK41 
                 86 
                 53 
                 0 
               
               
                   
                 CK42 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK43 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK44 
                 80 
                 25 
                 10 
               
               
                   
                 CK45 
                 86 
                 12 
                 0 
               
               
                   
                 CK46 
                 100 
                 10 
                 0 
               
               
                   
                 CK48 
                 40 
                 /// 
                 /// 
               
               
                   
                 CK51 
                 57 
                 /// 
                 /// 
               
               
                   
                 CK52 
                 20 
                 /// 
                 /// 
               
               
                   
                 CK53 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK55 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK56 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK57 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK58 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK59 
                 57 
                 /// 
                 /// 
               
               
                   
                 CK60 
                 86 
                 25 
                 15 
               
               
                   
                 CK61 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK63 
                 57 
                 /// 
                 /// 
               
               
                   
                 CK65 
                 86 
                 35 
                 5 
               
               
                   
                 CK66 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK67 
                 14 
                 /// 
                 /// 
               
               
                   
                 CK68 
                 14 
                 /// 
                 /// 
               
               
                   
                 CK69 
                 100 
                 5 
                 0 
               
               
                   
                 CK70 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK71 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK72 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK74 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK75 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK76 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK77 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK78 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK79 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK80 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK81 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK82 
                 17 
                 /// 
                 /// 
               
               
                   
                 CK83 
                 17 
                 /// 
                 /// 
               
               
                   
                 CK84 
                 0 
                 /// 
                 /// 
               
               
                   
                 diflumetorim 
                 0 
                 /// 
                 /// 
               
               
                   
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 307 
               
             
             
               
                   
               
               
                 contrastive tests against armyworm 
               
             
          
           
               
                   
                 Insecticidal activity against 
               
               
                   
                 armyworm (%) 
               
             
          
           
               
                   
                 Compound No. 
                 600 mg/L 
                 100 mg/L 
                 10 mg/L 
               
               
                   
                   
               
             
          
           
               
                   
                 I-255 
                 100 
                 100 
                 25 
               
               
                   
                 I-3309 
                 100 
                 100 
                 60 
               
               
                   
                 I-6756 
                 100 
                 100 
                 28 
               
               
                   
                 I-6757 
                 100 
                 100 
                 28 
               
               
                   
                 II-204 
                 100 
                 100 
                 47 
               
               
                   
                 II-297 
                 100 
                 95 
                 30 
               
               
                   
                 II-482 
                 100 
                 100 
                 80 
               
               
                   
                 II-8915 
                 100 
                 95 
                 44 
               
               
                   
                 II-8965 
                 100 
                 100 
                 69 
               
               
                   
                 II-19334 
                 100 
                 84 
                 44 
               
               
                   
                 III-22 
                 100 
                 100 
                 71 
               
               
                   
                 III-187 
                 100 
                 100 
                 95 
               
               
                   
                 III-199 
                 100 
                 100 
                 64 
               
               
                   
                 III-202 
                 100 
                 100 
                 65 
               
               
                   
                 III-547 
                 100 
                 100 
                 95 
               
               
                   
                 III-556 
                 100 
                 75 
                 45 
               
               
                   
                 III-562 
                 100 
                 100 
                 83 
               
               
                   
                 CK4 
                 40 
                 /// 
                 /// 
               
               
                   
                 CK5 
                 100 
                 56 
                 0 
               
               
                   
                 CK6 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK7 
                 100 
                 0 
                 0 
               
               
                   
                 CK8 
                 17 
                 /// 
                 /// 
               
               
                   
                 CK9 
                 40 
                 /// 
                 /// 
               
               
                   
                 CK10 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK11 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK12 
                 86 
                 20 
                 0 
               
               
                   
                 CK13 
                 86 
                 0 
                 0 
               
               
                   
                 CK14 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK15 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK16 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK17 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK18 
                 100 
                 43 
                 14 
               
               
                   
                 CK19 
                 86 
                 25 
                 7 
               
               
                   
                 CK20 
                 /// 
                 /// 
                 0 
               
               
                   
                 CK21 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK22 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK23 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK24 
                 /// 
                 /// 
                 0 
               
               
                   
                 CK25 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK26 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK27 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK28 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK29 
                 14 
                 /// 
                 /// 
               
               
                   
                 CK30 
                 57 
                 /// 
                 /// 
               
               
                   
                 CK32 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK33 
                 100 
                 0 
                 0 
               
               
                   
                 CK34 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK35 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK36 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK37 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK38 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK39 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK40 
                 43 
                 6 
                 0 
               
               
                   
                 CK41 
                 100 
                 0 
                 0 
               
               
                   
                 CK42 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK43 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK44 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK45 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK46 
                 71 
                 0 
                 0 
               
               
                   
                 CK47 
                 86 
                 25 
                 0 
               
               
                   
                 CK48 
                 50 
                 /// 
                 /// 
               
               
                   
                 CK49 
                 17 
                 /// 
                 /// 
               
               
                   
                 CK51 
                 43 
                 /// 
                 /// 
               
               
                   
                 CK52 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK53 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK54 
                 67 
                 /// 
                 /// 
               
               
                   
                 CK55 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK56 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK57 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK58 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK59 
                 14 
                 /// 
                 /// 
               
               
                   
                 CK60 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK61 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK63 
                 71 
                 /// 
                 /// 
               
               
                   
                 CK64 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK65 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK66 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK67 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK68 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK70 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK71 
                 86 
                 /// 
                 /// 
               
               
                   
                 CK72 
                 71 
                 /// 
                 /// 
               
               
                   
                 CK73 
                 100 
                 50 
                 0 
               
               
                   
                 CK74 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK75 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK76 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK77 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK78 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK79 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK80 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK81 
                 14 
                 /// 
                 /// 
               
               
                   
                 CK82 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK83 
                 29 
                 /// 
                 /// 
               
               
                   
                 CK84 
                 0 
                 /// 
                 /// 
               
               
                   
                 diflumetorim 
                 0 
                 /// 
                 /// 
               
               
                   
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 308 
               
             
             
               
                   
               
               
                 contrastive tests against peach aphid 
               
             
          
           
               
                   
                 Insecticidal activity against peach aphid (%) 
               
             
          
           
               
                 Compound 
                 600  
                 100  
                 10  
                 5 
                 2.5 
                 1.25 
               
               
                 No. 
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L  
                 mg/L 
               
               
                   
               
             
          
           
               
                 I-22 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 I-254 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 I-3309 
                 100 
                 100 
                 100 
                 100 
                 96 
                 48 
               
               
                 I-6731 
                 100 
                 100 
                 100 
                 100 
                 93 
                 60 
               
               
                 I-6735 
                 100 
                 100 
                 100 
                 100 
                 80 
                 67 
               
               
                 I-6739 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 I-6756 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 I-6757 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 I-6758 
                 100 
                 100 
                 100 
                 100 
                 100 
                 89 
               
               
                 I-6765 
                 100 
                 100 
                 100 
                 100 
                 100 
                 84 
               
               
                 II-19 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-69 
                 100 
                 100 
                 100 
                 100 
                 81 
                 /// 
               
               
                 II-204 
                 100 
                 100 
                 100 
                 100 
                 97 
                 60 
               
               
                 II-297 
                 100 
                 100 
                 100 
                 100 
                 100 
                 93 
               
               
                 II-347 
                 100 
                 100 
                 100 
                 100 
                 100 
                 81 
               
               
                 II-482 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 II-1687 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-1965 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-8915 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 II-8917 
                 100 
                 100 
                 100 
                 83 
                 /// 
                 /// 
               
               
                 II-8965 
                 100 
                 100 
                 100 
                 91 
                 /// 
                 /// 
               
               
                 II-10583 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 II-19334 
                 100 
                 100 
                 100 
                 96 
                 83 
                 67 
               
               
                 III-7 
                 100 
                 100 
                 90 
                 88 
                 /// 
                 /// 
               
               
                 III-22  
                 100 
                 100 
                 100 
                 100 
                 98 
                 67 
               
               
                 III-181 
                 100 
                 100 
                 100  
                 /// 
                 /// 
                 /// 
               
               
                 III-187  
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-202 
                 100 
                 100 
                 100 
                 100 
                 100 
                 94 
               
               
                 III-301  
                 100 
                 100 
                 100  
                 /// 
                 /// 
                 /// 
               
               
                 III-547 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 III-562 
                 100 
                 100 
                 100 
                 /// 
                 /// 
                 /// 
               
               
                 CK2 
                 100 
                 100 
                 95 
                 37 
                 23 
                 0 
               
               
                 CK4 
                 100 
                 100 
                 64 
                 41 
                 0 
                 /// 
               
               
                 CK6 
                 100 
                 76 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK7 
                 100 
                 100 
                 59 
                 /// 
                 /// 
                 /// 
               
               
                 CK8 
                 0 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK9 
                 100 
                 79 
                 23 
                 /// 
                 /// 
                 /// 
               
               
                 CK10 
                 100 
                 91 
                 23 
                 /// 
                 /// 
                 /// 
               
               
                 CK11 
                 100 
                 98 
                 85 
                 25 
                 0 
                 /// 
               
               
                 CK12 
                 100 
                 100 
                 73 
                 /// 
                 /// 
                 /// 
               
               
                 CK13 
                 100 
                 98 
                 83 
                 0 
                 /// 
                 /// 
               
               
                 CK14 
                 100 
                 70 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK15 
                 69 
                 40 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK16 
                 64 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK17 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK18 
                 100 
                 71 
                 51 
                 7 
                 0 
                 /// 
               
               
                 CK19 
                 100 
                 86 
                 33 
                 /// 
                 /// 
                 /// 
               
               
                 CK21 
                 100 
                 98 
                 35 
                 19 
                 0 
                 /// 
               
               
                 CK22 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK23 
                 0 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK24 
                 100 
                 100 
                 89 
                 28 
                 0 
                 /// 
               
               
                 CK25 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK26 
                 100 
                 48 
                 45 
                 /// 
                 /// 
                 /// 
               
               
                 CK27 
                 0 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK28 
                 100 
                 100 
                 43 
                 /// 
                 /// 
                 /// 
               
               
                 CK29 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK30 
                 93 
                 50 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK32 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK33 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK34 
                 65 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK35 
                 0 
                 /// 
                 ///  
                 /// 
                 /// 
                 /// 
               
               
                 CK36 
                 90 
                 14 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK37 
                 100 
                 16 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK38 
                 100 
                 24 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK39 
                 100 
                 86 
                 2 
                 0 
                 /// 
                 /// 
               
               
                 CK40 
                 100 
                 100 
                 72 
                 27 
                 0 
                 /// 
               
               
                 CK41 
                 100 
                 97 
                 23 
                 15 
                 0 
                 /// 
               
               
                 CK42 
                 100 
                 67 
                 20 
                 17 
                 0 
                 /// 
               
               
                 CK43 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK44 
                 100 
                 98 
                 35 
                 19 
                 0 
                 /// 
               
               
                 CK45 
                 100 
                 98 
                 55 
                 39 
                 26 
                 0 
               
               
                 CK46 
                 100 
                 5 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK48 
                 100 
                 87 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK51 
                 100 
                 50 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK52 
                 88 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK53 
                 84 
                 66 
                 34 
                 /// 
                 /// 
                 /// 
               
               
                 CK54 
                 100 
                 100 
                 34 
                 /// 
                 /// 
                 /// 
               
               
                 CK55 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK56 
                 100 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK57 
                 61 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK58 
                 100 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK59 
                 75 
                 15 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK60 
                 81 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK61 
                 88 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK63 
                 100 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK65 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK66 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK67 
                 86 
                 54 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK68 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK69 
                 100 
                 100 
                 70 
                 /// 
                 /// 
                 /// 
               
               
                 CK70 
                 81 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK72 
                 55 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK73 
                 100 
                 100 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK74 
                 100 
                 100 
                 26 
                 /// 
                 /// 
                 /// 
               
               
                 CK75 
                 100 
                 0 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK76 
                 52 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK77 
                 72 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK78 
                 0 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK79 
                 100 
                 16 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK80 
                 87 
                 40 
                 16 
                 /// 
                 /// 
                 /// 
               
               
                 CK81 
                 75 
                 /// 
                 /// 
                 /// 
                 /// 
                 /// 
               
               
                 CK82 
                 86 
                 130 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 CK83 
                 100 
                 100 
                 11 
                 /// 
                 /// 
                 /// 
               
               
                 CK84 
                 100 
                 43 
                 7 
                 /// 
                 /// 
                 /// 
               
               
                 diflumetorim 
                 100 
                 35 
                 0 
                 /// 
                 /// 
                 /// 
               
               
                 flufenerim 
                 100 
                 100 
                 100 
                 100 
                 90 
                 37 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 309 
               
             
             
               
                   
               
               
                 contrastive tests against carmine spider mite 
               
             
          
           
               
                   
                   
                 Insecticidal activity against 
               
               
                   
                 Compound 
                 carmine spider mite (% ) 
               
             
          
           
               
                   
                 No. 
                 600 mg/L  
                 100 mg/L  
                 10 mg/L 
               
               
                   
                   
               
             
          
           
               
                   
                 I-22 
                 100 
                 100 
                 74 
               
               
                   
                 I-254 
                 100 
                 100 
                 97 
               
               
                   
                 I-255 
                 100 
                 100 
                 85 
               
               
                   
                 I-987 
                 100 
                 100 
                 80 
               
               
                   
                 I-6729 
                 100 
                 100 
                 87 
               
               
                   
                 I-6734 
                 100 
                 100 
                 82 
               
               
                   
                 I-6757 
                 100 
                 100 
                 97 
               
               
                   
                 I-6758 
                 100 
                 100 
                 99 
               
               
                   
                 I-6739 
                 100 
                 100 
                 100 
               
               
                   
                 I-6756 
                 100 
                 100 
                 100 
               
               
                   
                 I-6741 
                 100 
                 100 
                 85 
               
               
                   
                 I-6765 
                 100 
                 100 
                 100 
               
               
                   
                 I-6740 
                 100 
                 100 
                 85 
               
               
                   
                 II-69 
                 100 
                 100 
                 90 
               
               
                   
                 II-204 
                 100 
                 100 
                 100 
               
               
                   
                 II-297 
                 100 
                 100 
                 74 
               
               
                   
                 II-299 
                 100 
                 100 
                 72 
               
               
                   
                 II-347 
                 100 
                 100 
                 100 
               
               
                   
                 II-432 
                 100 
                 100 
                 76 
               
               
                   
                 II-443 
                 100 
                 100 
                 83 
               
               
                   
                 II-482 
                 100 
                 100 
                 100 
               
               
                   
                 II-8965 
                 100 
                 100 
                 100 
               
               
                   
                 II-19334 
                 100 
                 100 
                 100 
               
               
                   
                 III-7 
                 100 
                 100 
                 /// 
               
               
                   
                 III-16 
                 100 
                 100 
                 /// 
               
               
                   
                 III-22 
                 100 
                 100 
                 72 
               
               
                   
                 III-181 
                 100 
                 100 
                 /// 
               
               
                   
                 III-199 
                 100 
                 100 
                 87 
               
               
                   
                 III-547 
                 100 
                 100 
                 /// 
               
               
                   
                 III-556 
                 100 
                 100 
                 /// 
               
               
                   
                 III-559 
                 100 
                 100 
                 /// 
               
               
                   
                 III-562 
                 100 
                 100 
                 88 
               
               
                   
                 CK2 
                 100 
                 100 
                 32 
               
               
                   
                 CK4 
                 75 
                 /// 
                 /// 
               
               
                   
                 CK6 
                 100 
                 53 
                 5 
               
               
                   
                 CK7 
                 100 
                 96 
                 36 
               
               
                   
                 CK8 
                 54 
                 /// 
                 /// 
               
               
                   
                 CK12 
                 100 
                 41 
                 /// 
               
               
                   
                 CK13 
                 100 
                 0 
                 0 
               
               
                   
                 CK14 
                 100 
                 33 
                 6 
               
               
                   
                 CK15 
                 59 
                 0 
                 0 
               
               
                   
                 CK16 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK17 
                 40 
                 /// 
                 /// 
               
               
                   
                 CK20 
                 100 
                 72 
                 /// 
               
               
                   
                 CK21 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK23 
                 64 
                 /// 
                 /// 
               
               
                   
                 CK24 
                 100 
                 100 
                 85 
               
               
                   
                 CK25 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK26 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK27 
                 100 
                 100 
                 18 
               
               
                   
                 CK28 
                 100 
                 100 
                 22 
               
               
                   
                 CK30 
                 100 
                 100 
                 28 
               
               
                   
                 CK32 
                 91 
                 22 
                 0 
               
               
                   
                 CK33 
                 41 
                 /// 
                 /// 
               
               
                   
                 CK34 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK35 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK36 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK37 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK38 
                 99 
                 37 
                 14 
               
               
                   
                 CK39 
                 100 
                 37 
                 16 
               
               
                   
                 CK41 
                 100 
                 99 
                 0 
               
               
                   
                 CK43 
                 74 
                 29 
                 16 
               
               
                   
                 CK44 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK45 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK46 
                 100 
                 63 
                 28 
               
               
                   
                 CK52 
                 44 
                 /// 
                 /// 
               
               
                   
                 CK53 
                 100 
                 100 
                 12 
               
               
                   
                 CK55 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK56 
                 32 
                 25 
                 0 
               
               
                   
                 CK57 
                 33 
                 /// 
                 /// 
               
               
                   
                 CK58 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK59 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK60 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK61 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK62 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK63 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK64 
                 56 
                 /// 
                 /// 
               
               
                   
                 CK65 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK66 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK67 
                 61 
                 /// 
                 /// 
               
               
                   
                 CK68 
                 4 
                 /// 
                 /// 
               
               
                   
                 CK69 
                 100 
                 100 
                 4 
               
               
                   
                 CK70 
                 13 
                 /// 
                 /// 
               
               
                   
                 CK72 
                 13 
                 /// 
                 /// 
               
               
                   
                 CK73 
                 100 
                 85 
                 24 
               
               
                   
                 CK74 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK75 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK76 
                 41 
                 /// 
                 /// 
               
               
                   
                 CK77 
                 56 
                 /// 
                 /// 
               
               
                   
                 CK78 
                 17 
                 /// 
                 /// 
               
               
                   
                 CK79 
                 27 
                 /// 
                 /// 
               
               
                   
                 CK80 
                 6 
                 /// 
                 /// 
               
               
                   
                 CK81 
                 0 
                 /// 
                 /// 
               
               
                   
                 CK82 
                 23 
                 /// 
                 /// 
               
               
                   
                 CK84 
                 100 
                 0 
                 0 
               
               
                   
                 diflumetorim 
                 100 
                 100 
                 73 
               
               
                   
                 flufenerim 
                 100 
                 100 
                 72 
               
               
                   
                   
               
             
          
         
       
     
     Further contrastive tests were carried out between the compounds with better activities, such as compound I-22, I-254, I-255, I-6729, I-6734, I-6739, I-6756, I-6757, I-6758, II-204, II-347, II-482, II-8965 and II-19334, and the contrast CK24 at a low dosage. The test results are listed in table 310. 
     
       
         
               
               
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                   
                 TABLE 310 
               
             
             
               
                   
                   
               
               
                   
                 Insecticidal activity 
                   
               
               
                   
                 against carmine 
               
               
                   
                 spider mite (%) 
               
             
          
           
               
                   
                 Compound No. 
                 5 mg/L 
                 2.5 mg/L 
               
               
                   
                   
               
             
          
           
               
                   
                 I-22 
                 59 
                 /// 
               
               
                   
                 I-254 
                 93 
                 79 
               
               
                   
                 I-255 
                 84 
                 72 
               
               
                   
                 I-6729 
                 78 
                 64 
               
               
                   
                 I-6734 
                 57 
                 51 
               
               
                   
                 I-6739 
                 93 
                 76 
               
               
                   
                 I-6756 
                 88 
                 71 
               
               
                   
                 I-6757 
                 80 
                 75 
               
               
                   
                 I-6758 
                 82 
                 79 
               
               
                   
                 II-204 
                 80 
                 60 
               
               
                   
                 II-347 
                 90 
                 75 
               
               
                   
                 II-482 
                 100 
                 93 
               
               
                   
                 II-8965 
                 92 
                 82 
               
               
                   
                 II-19334 
                 100 
                 87 
               
               
                   
                 CK24 
                 15 
                 5