Abstract:
Useful chiral specific boron-containing compounds, such as boronate, boronate esters, boranamines, borane diamines, boranamine thioesters, and boronic mono/di-thioesters, have been prepared. These compounds and compositions containing them are useful as anti-cancer or anti-amyloidosis agents.

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
       [0001]    This application is based upon and claims the benefit of the filing date of U.S. Provisional Patent Application Ser. No. 62/181,910, filed Jun. 19, 2015, the entirety of which is incorporated herein by reference. 
     
    
     FIELD OF THE INVENTION 
       [0002]    The invention herein is directed to chiral specific boron-containing compounds, such as boronate, boronate esters, boranamines, boranediamines, boranamine thioesters, and boronic mono/di-thioesters, as anti-cancer or anti-amyloidosis agents, as well as their compositions, methods of preparation, and methods of treatment. 
       BACKGROUND OF THE INVENTION 
       [0003]    It is known that some peptide boronic acid compounds are proteasome inhibitors, and they represent an important strategy in cancer therapy. Besides the marketed drug VELCADE® (Bortezomib or chemical name as [(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid) for the treatment of multiple myeloma, other types of cancers, and amyloidosis. There are a number of structurally different peptide boronic acids at various stages of clinical trials. One major issue of this group of boronic acids as (active pharmaceutical ingredient (API) is that they are not very stable at ambient conditions. The drug VELCADE®, for example, needs to be stored at below ambient temperature and kept away from light. Partially related to its instability, the drug VELCADE® is formulated as an injection mixture, and patients must go to doctors&#39; offices or hospitals for drug administration. Boronic acids are known to form many boronic acid derivatives, such as boronates and boronate esters. Boronates and boronate esters are able to be converted back to boronic acid under certain conditions. 
         [0004]    The present invention describes a group of boron-containing compounds, such as boronate, boronate esters, boranamines, boranediamines, boranamine thioesters, and boronic mono/di-thioesters, that are stable at ambient conditions. They can be formulated as both liquid and solid drugs. Therefore, the bioactive component of the drug can be circulated longer in the human body and reach more areas unavailable to the direct injection into blood vessels. 
       DEFINITION OF TERMS 
       [0005]    Unless otherwise explicitly stated, R is intended to refer an aliphatic or aromatic group. 
         [0006]    Unless otherwise explicitly stated, the term “aliphatic” or “aliphatic group” is intended to refer a substituted or unsubstituted straight-chain, branched or cyclic C 1 -C 12  hydrocarbon, which is completely saturated or which contains one or more units of unsaturation, but which is not aromatic. Aliphatic group also includes atoms other than C in the backbone, such as, but not limited to, N, S, and O. Aliphatic group also includes one or more functional groups attached to the backbone, such as, but not limited to, —OH, —SH, —CO—OH, —CO—OR (ester), —NH 2 , —NHR, —CO—R (ketone), —O—SO 2  (sulfonate), —NH—SO 2  (sulfonamide) and —NR—SO 2  (sulfonamide). 
         [0007]    Unless otherwise explicitly stated, the term “aromatic” or “aromatic group” is intended to refer a substituted or unsubstituted planar unsaturated ring of atoms that is stabilized by an interaction of the bonds forming the ring. Atoms forming an aromatic group include, but are not limited to, C, O, S, and N. 
         [0008]    Unless otherwise explicitly stated, the term “peptide” is intended to refer to a short chain of amino acid monomers linked by amide (—NH—CO— or —NR—CO—) bonds. R represents an aliphatic or aromatic group. Each C atom in the amino acid monomer may have one or two substitution groups, and the substitution groups are aliphatic, aromatic or both aliphatic and aromatic. The covalent chemical bonds are formed when the carboxyl group of one amino acid reacts with the amino group of another. 
         [0009]    Unless otherwise explicitly stated, the term “backbone” is intended to refer to the longest hydrocarbon chain in a molecule or a group. It also refers to the longest hydrocarbon chain with other atoms in the chain, such as, but not limited to, O, S, and N, in a molecule or a group. 
         [0010]    Boronate, boronate esters, boranamines, boranediamines, boranamine thioesters and boronic mono/di-thioesters are illustrated by the corresponding general structures showed below. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0011]    In the compounds of this invention any atom not specifically designated as a particular isotope is meant to represent any stable isotope of that atom. Unless otherwise stated, when a position is designated specifically as “H” or “hydrogen”, the position is understood to have hydrogen at its natural abundance isotopic composition. Also, unless otherwise stated, when a position is designated specifically as “D” or “deuterium”, the position is understood to have deuterium at an abundance that is at least 3000 times greater than the natural abundance of deuterium, which is 0.015% (i.e., at least 45% incorporation of deuterium). 
       SUMMARY OF THE INVENTION 
       [0012]    The present invention provides novel boron-containing compounds and stable pharmaceutically acceptable compositions comprising them. These compounds are useful in treatment of diseases, such as cancers, cancerous conditions, plaque, or a plaque-forming condition such as amyloidosis, in a human or warm-blooded animal or mammal. 
         [0013]    In one aspect of the invention, compounds of the general formula (I), or pharmaceutically acceptable salts thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0014]    Z 3  is a peptide containing 1-20 amide bonds and the boron atom in formula (I) attaches to a C atom, not an N atom nor —C═O; 
         [0015]    Z 1  and Z 2  are structurally the same or different side chains attached to boron atom in the formula (I); 
         [0016]    Z 1  and Z 2  are each represented by the formula: 
         [0000]      —X—R 1   Formula (II)
 
         [0000]    wherein: 
         [0017]    X is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —SO 2 , —NH—SO 2 , or —NR—SO 2 , R being an aliphatic or aromatic substitution group; and 
         [0018]    R 1  is an aliphatic chain with C 1 -C 20  hydrocarbon; R 1  also represents an aliphatic chain with C 1 -C 20  hydrocarbon which has one or more X in the backbone; R 1  also represents an aliphatic chain with C 1 -C 20  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0019]    In another aspect of the invention, compounds of the general formula (III), or pharmaceutically acceptable salts thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0020]    Z 3  is a peptide containing 1-20 amide bonds and the boron atom attaches in formula (III) to a C atom, not an N atom nor —C═O; 
         [0021]    Z 4  and Z 5  each attach to the boron atom in the formula (III) and also join together on the other end to form a ring; 
         [0022]    the ring formed by joining Z 4  and Z 5  together with boron is represented by formula (IV): 
         [0023]    the ring size counting all atoms on the backbone of the ring in formula (IV) is 4-20 atoms; and 
         [0024]    the backbone of the compound in formula (IV) constructed with atoms such as, but not limited to, B, C, O, S, and N: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0025]    X 1  and X 2  in formula (IV) are atoms or links or linkers, and they are the same or different; 
         [0026]    X 1  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0027]    X 2  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0028]    R is an aliphatic or aromatic substitution group; and R 2  in formula (IV) represents the rest of the backbone of the ring besides B, X 1 , and X 2 : R 2  also represents an aliphatic chain with C 1 -C 20  hydrocarbon which has one or more X 1  or X 2  in the backbone; R 2  also represents an aliphatic chain with C 1 -C 20  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0029]    In some cases, two substitutions on the backbone of R 2  also form another ring A which is illustrated by formula (V): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0030]    the size of ring A in formula (V) is 3-10 atoms; and 
         [0031]    Ring A in formula (V) is constructed by atoms such as, but not limited to, C, O, S, or N. 
         [0032]    In another aspect of the invention, compounds of the general formula (VI), or pharmaceutically acceptable salts thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0033]    Z 3  is a peptide containing 1-20 amide bonds and each boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0034]    Rings B and C are the same or different; 
         [0035]    Rings B and C have the same descriptions as compounds represented by formula (III): 
         [0036]    X 3  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0037]    X 4  is O, S, NH, NR, O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0038]    X 5  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0039]    X 6  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0040]    R is an aliphatic or aromatic substitution group; 
         [0041]    Rings B and C in compounds represented by formula (VI) are connected by link or linker R 3 ; 
         [0042]    In compounds represented by formula (VI), link or linker R 3  connects with X 7  in ring B and X 8  in ring C; 
         [0043]    In compounds represented by formula (VI), X 7  is C, N, or other atoms or groups that can form three bonds; X 8  is C, N, or other atoms or group that can form three bonds; and 
         [0044]    In compounds represented by formula (VI), R 3  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 3  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 3  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0045]    In another aspect of the invention, compounds of the general formula (VII), or pharmaceutically acceptable salts thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0046]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not N atom nor —C═O; 
         [0047]    Ring D in formula (VII) has two boron atoms; 
         [0048]    the size of ring D counting for all atoms in the backbone of the ring in formula (VII) is 6-20 atoms; 
         [0049]    X 9 , X 10 , X 11 , and X 12  in formula (VII) are the same or different; 
         [0050]    X 9  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0051]    X 10  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0052]    X 11  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0053]    X 12  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0054]    R is an aliphatic or aromatic substitution group; 
         [0055]    R 4  and R 5  in formula (VII) are the same or different; 
         [0056]    In compounds represented by formula (VII), R 4  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 4  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 4  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone; and 
         [0057]    In compounds represented by formula (VII), R 5  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 5  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 5  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0058]    In another aspect of the invention, compounds of the general formula (VIII), or pharmaceutically acceptable salts or thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0059]    Z 3  is a peptide containing 1-20 amide bonds and each boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0060]    Ring E in formula (VIII) has three boron atoms; 
         [0061]    the size of ring E counting for all atoms in the backbone of the ring in formula (VII) is 9-20 atoms; 
         [0062]    X 13 , X 14 , X 15 , X 16 , X 17 , and X 18  in formula (VII) are the same or different; 
         [0063]    X 13  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO —O—SO 2 , —NH—SO 2 , or —NR—S 2 ; 
         [0064]    X 14  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0065]    X 15  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0066]    X 16  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0067]    X 17  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0068]    X 18  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0069]    R is an aliphatic or aromatic substitution group; 
         [0070]    R 6 , R 7 , and R 8  in formula (VIII) are the same or different; 
         [0071]    In compounds represented by formula (VIII), R 6  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 6  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 6  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone; 
         [0072]    In compounds represented by formula (VIII), R 7  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 7  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 7  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone; and 
         [0073]    In compounds represented by formula (VIII), R 8  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 8  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 8  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0074]    In another aspect of the invention, compounds of the general formula (IX), or pharmaceutically acceptable salts thereof, are provided: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein: 
         [0075]    Z 3  is a peptide containing 1-20 amide bonds and the boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0076]    R 10  is a substitution branch on backbone of Z 3 ; 
         [0077]    R 10  forms ring F with boron in formula (IX); 
         [0078]    the size of ring F counting all atoms on the ring is 4-10 atoms; 
         [0079]    X 19  is directly attached to boron in ring F; 
         [0080]    X 19  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0081]    R is an aliphatic or aromatic substitution group; 
         [0082]    In compounds represented by formula (IX), R 10  represents an aliphatic chain with C 1 -C 10  hydrocarbon; R 10  also represents an aliphatic chain with C 1-10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 10  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone; 
         [0083]    In compounds represented by formula (IX), X 20  is directly attached to boron and is not in ring F; 
         [0084]    X 20  is O, S, NH, NR, —O—CO, —NH—CO, —NR—CO, —O—SO 2 , —NH—SO 2 , or —NR—SO 2 ; 
         [0085]    R is an aliphatic or aromatic substitution group; 
         [0086]    In compounds represented by formula (IX), R 9  attaches to X 20 ; and 
         [0087]    R 9  represents an aliphatic chain with C 1-10  hydrocarbon; R 9  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more other atoms such as, but not limited to, O, S, or N in the backbone; R 9  also represents an aliphatic chain with C 1 -C 10  hydrocarbon which has one or more aliphatic, aromatic, or both aliphatic and aromatic substitution groups on the backbone. 
         [0088]    In another aspect of the invention, a pharmaceutical composition comprises a compound of formula (I), (III), (IV), (V), (VI), (VII), (VIII), or (IX), or a pharmaceutically acceptable crystalline form thereof, suitable for the production of a drug in solid and/or liquid formulation. 
         [0089]    Another aspect of the invention is directed to methods for the use of a pharmaceutical composition comprising one or more of the compounds described above to treat a patient who has or is at risk to have proteasome-mediated diseases, including cancers, or amyloidosis. 
         [0090]    Non-toxic, pharmacologically acceptable salts useful herein comprise acid addition salts formed with inorganic or organic acids. Examples of suitable such salts include hydrohalides such as hydrochlorides, sulfates, hydrogen sulfates, phosphates, hydrogen phosphates, tartrates, succinates, maleates, benzoates, acetates, propionates, lactates, ascorbinates, and the like. 
         [0091]    The compounds of formulae (I), (III), (IV), (V), (VI), (VII), (VIII), and (IX) according to the invention can be converted into their non-toxic, pharmacologically acceptable acid addition salts in conventional manner. Acids suitable for salt formation include, for example, hydrochloric acid, hydrobromic acid, hydriodic acid, hydrofluoric acid, sulfuric acid, phosphoric acid, nitric acid, acetic acid, propionic acid, butyric acid, caproic acid, valeric acid, oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid, lactic acid, tartaric acid, citric acid, malic acid, benzoic acid, p-hydroxybenzoic acid, p-aminobenzoic acid, phthalic acid, cinnamic acid, salicyclic acid, ascorbic acid, methanesulfonic acid, 8-chlorotheophyllin, and the like. 
         [0092]    The compounds of formulae (I), (III), (IV), (V), (VI), (VII), (VIII), and (IX) and pharmaceutically acceptable salts thereof can be incorporated, optionally in combination with other active ingredients, into the usual pharmaceutical preparations such as tablets, coated tablets, capsules, powders, suppositories, or solutions. Such preparations may be produced with use of conventional pharmaceutical excipients, carriers, disintegrants, or lubricants or substances for obtaining delayed or sustained release. The single dose for adults is from about 0.1 to 80 mg (from about 0.0013 to 1.07 mg/kg), preferably, however, from about 1 to 30 mg (from about 0.013 to 0.40 mg/kg), 1 to 4 times daily. 
         [0093]    Dependent upon the type and body weight of the patient to be treated, on the type and severity of the disease, on the type of preparation, and on the route of administration, which may be peroral, parenteral, or rectal, as well as on the period or interval over which the administration takes place, it may, however, be necessary to deviate from the above dosages. Thus, it may be sufficient in some cases to administer less than the above-mentioned amount of active ingredient or in some cases the amount may be exceeded. The optimum dosage and route of administration of the active ingredients which are necessary in each case can easily be determined by one skilled in the art. 
         [0094]    Another aspect of the invention is directed to a compound of the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous forms, thereof,
 
wherein:
 
         [0095]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0096]    Y 3  is C 1  to C 5 , O, S, NH, or NR; 
         [0097]    R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; 
         [0098]    each Ra 1  and Ra 2  independently is H, aliphatic, or aromatic substitution group; 
         [0099]    each Ra 3  and Ra 4  independently is H, aliphatic, or aromatic substitution group; 
         [0100]    q is 0, 1, or 2; and 
         [0101]    r is 0, 1, or 2. 
         [0102]    In another aspect of the invention, Z 3  is characterized by the bare bones structure or its derivatives of formula (XI-1): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0103]    In another aspect of the invention, Z 3  is characterized by the bare bones structure or its derivatives of formula (XI-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0104]    In another aspect of the invention, Z 3  is characterized by the bare bones structure or its derivatives of formula (XI-3): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0105]    In another aspect of the invention, the compound is one of: 
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
         [0106]    Another aspect of the invention is directed to a compound of the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0107]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom or —C═O; 
         [0108]    each of Y 1 , Y 2  and Y 3  independently is O, S, NH, or NR; Y 3  can also be C 1  to C 5 ; 
         [0109]    R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; 
         [0110]    each Rb 1  and Rb 2  independently is H, aliphatic, or aromatic substitution group; Rb 1  and Rb 2  can also be a double bond, such as carbonyl group; each Rb 3  and Rb 4  independently is H, aliphatic, or aromatic substitution group; 
         [0111]    s is 0, 1, or 2; and 
         [0112]    t is 0, 1, or 2. 
         [0113]    Another aspect of the invention is directed to the compound characterized by the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0114]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0115]    each Rc 1  and Rc 2  independently is H, aliphatic, or aromatic substitution group; 
         [0116]    each Rc 3  and Rc 4  independently is H, aliphatic, or aromatic substitution group, —(CH2) p —COOH and —(CH2) p —COOR wherein R is an aliphatic or aromatic group, with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; and 
         [0117]    u is 0, 1, or 2. 
         [0118]    In another aspect of the invention, the compound is characterized by the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous forms, thereof, wherein: 
         [0119]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; and 
         [0120]    each Rd 1  and Rd 2  independently is H, aliphatic, aromatic substitution group, —(CH2) p —COOH and —(CH2) p —COOR wherein R is an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 . 
         [0121]    In another aspect of the invention, the compound is characterized by the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0122]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0123]    each Re 1  and Re 2  independently is H, aliphatic, aromatic substitution group, —(CH2) p —COOH and —(CH2) p —COOR wherein R is an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; and 
         [0124]    each Re 3  and Re 4  independently is H, aliphatic, aromatic substitution group, —(CH2) p —COOH and —(CH2) p —COOR wherein R is an aliphatic or aromatic group. 
         [0125]    In another aspect of the invention, the compound is characterized by the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0126]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0127]    each Rf 1  and Rf 2  independently is H, aliphatic, aromatic substitution group; 
         [0128]    each Rf 3  and Rf 4  independently is H, aliphatic, aromatic substitution group, —(CH 2 ) p —COOH and —(CH 2 ) p —COOR wherein R is an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; and 
         [0129]    v is 0, 1, or 2. 
         [0130]    In another aspect of the invention, the compound is characterized by the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0131]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0132]    R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; 
         [0133]    each Rg 1  and Rg 2  independently is H, aliphatic, aromatic substitution group; 
         [0134]    each Rg 3  and Rg 4  independently is H, aliphatic, aromatic substitution group, —(CH2) p —COOH and —(CH2) p —COOR wherein R is an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, NH 2 ; and 
         [0135]    w is 0, 1, or 2. 
         [0136]    In another aspect of the invention, the compound is one of the following: 
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
         [0137]    In another aspect of the invention, a medically useful composition comprises one or more of the compounds described herein in combination with pharmaceutically acceptable excipients, formulates as drugs in solid or liquid forms. 
         [0138]    In another aspect of the medically useful compositions of the invention, the one or more compounds are present in an amount effective to treat cancer, a cancerous condition, such as multiple myeloma, or amyloidosis in a human or mammal. 
         [0139]    Another aspect of the invention is directed a process for the preparation of compounds of the formula: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    or a pharmaceutically acceptable salt, solvate, and/or hydrate, polymorph crystal or amorphous form thereof,
 
wherein:
 
         [0140]    Z 3  is a peptide containing 1-20 amide bonds and boron atom attaches to a C atom, not an N atom nor —C═O; 
         [0141]    Y 3  is C 1  to C 5 , O, S, NH, or NR; R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; 
         [0142]    each Ra 1  and Ra 2  independently is H, aliphatic, aromatic substitution group; 
         [0143]    each Ra 3  and Ra 4  independently is H, aliphatic, aromatic substitution group; 
         [0144]    q is 0, 1, or 2; and 
         [0145]    r is 0, 1, or 2. 
         [0146]    In another aspect of the invention, a compound of formula (XI-1) is reacted with N-methyliminodiacetic acid to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL01-011 is X-2. 
         [0147]    In another aspect of the invention, a compound of formula (XI-3) is reacted with N-methyliminodiacetic acid to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-00 is XI-3 and HL01-015 is X-2. 
         [0148]    In another aspect of the invention, a compound of formula (XI-2) is reacted with N-methyliminodiacetic acid to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-000 is XI-2 and HL01-016 is X-2. 
         [0149]    In another aspect of the invention, a compound of formula (XI-1) is reacted with EDTA to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL01-08 is X-2. 
         [0150]    In another aspect of the invention, a compound of formula (XI-1) is reacted with EDTA to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL01-08-1 is X-2. 
         [0151]    In another aspect of the invention, a compound of formula (XI-1) is reacted with N-ethyl-iminodiacetic acid to form a compound of formula (X-2): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL01-34 is X-2. 
         [0152]    In another aspect of the invention, a compound of formula (XI-1) is reacted with N-methyldiethanolamine to form a compound of formula (XII): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL01-33 is XII. 
         [0153]    In another aspect of the invention, a compound of formula (XI-3) is coupled or reacted with an ester of amino substituted L-tartaric acid derivative to form a compound of formula (XI): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-00 is XI-3 and HL-245 is XI. 
         [0154]    In another aspect of the invention, a compound of formula (XI-1) is reacted with N-methyliminodiacetic acid to form a compound of formula (XII): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL-448 is XII. 
         [0155]    In another aspect of the invention, a compound of formula (XI-1) is coupled or reacted with N-ethyldiethanolamine to form a compound of formula (XII): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein, HL01-0 is XI-1 and HL-505 is XII. 
         [0156]    In another aspect of the invention, a composition for treating cancer, a cancerous condition, or amyloidosis in a human or mammal, comprises as active ingredient a pharmaceutically effective amount of a compound described herein, including, but not limited to, a compound of formulae (I), (III), (IV), (V), (VI), (VII), (VIII), and (IX) or a pharmaceutically acceptable acid addition salt thereof, in combination with pharmaceutically acceptable carriers, diluents, or excipients. 
         [0157]    In another aspect of the invention, the composition comprises active ingredient in an amount effective to treat multiple myeloma or amyloidosis. 
         [0158]    In another aspect of the invention, in a method of treating cancer, a cancerous condition, or amyloidosis in a human or mammal host in need of such treatment, the method comprises perorally, parentally, or rectally administering to said host an effective cancer, cancerous condition, or amyloidosis treatment amount of a compound of formula (I), (III), (IV), (V), (VI), (VII), (VIII), or (IX) or a pharmaceutically acceptable acid addition salt thereof. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWING 
         [0159]      FIG. 1  is a graph that represents the results of testing to demonstrate the cytotoxic effects of certain compounds, including compounds prepared according to the invention. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0160]    The invention can perhaps be appreciated better from the description below, where compounds of the invention have been prepared and then some testing is described. 
       EXAMPLES 
       [0161]    Boronic acid can readily form oligomeric anhydrides by dehydration of the boronic acid moiety. Hence, the monomeric structure form drawn below, such as HL01-0 drawn in the Example 1, is expressly intended to represent the free boronic acid, oligomeric anhydrides, including, but not limited to, dimers, trimers, and tetramers, and mixtures thereof. 
         [0162]    Abbreviations: Bortezomib (HL01-0), Tetrahydrofuran (THF), Ethyl Acetate (EtOAc or EA), N,N-Dimethylsulfoxide (DMSO), Ethylenediaminetetraacetic Acid (EDTA), Hydrogen Chloride (HCl), room temperature (RT), Nuclear Magentci Resonance (NMR), Reverse Phase High Performance Liquid Chromatography (RP-HPLC), Liquid Chromatography-Mass Spectroscopy (LC-MS) 
         [0163]    General Characterization Methods:  1 H NMR,  13 C NMR, HPLC, LCMS. 
         [0164]    The product HL01-01 of Example 1, characterized by formula HL01-01-1, HL-01-01-2, HL-01-01-3, HL-01-01-4, HL-1-01-5, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0165]    The product HL01-02 of Example 2, characterized by formula HL01-02-1, HL-01-02-2, HL-01-02-3, HL-01-02-4, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0166]    The product HL01-17 of Example 15, characterized by formula HL01-17-1, HL-01-17-2, HL-01-17-3, HL-01-17-4, HL-1-17-5, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0167]    The product HL01-18 of Example 16, characterized by formula HL01-18-1, HL-01-18-2, HL-01-18-3, HL-01-18-4, HL-1-18-5, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0168]    The product HL01-23 of Example 23, characterized by formula HL01-23-1, HL-01-23-2, HL-01-23-3, HL-01-23-4, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0169]    The product HL01-28 of Example 28, characterized by formula HL01-28-1, HL-01-28-2, HL-01-28-3, HL-01-28-4, or a mixture thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
       Example 1 
       [0170]    
       
                 
         
             
             
         
       
     
         [0171]    Bortezomib (HL01-0, 1.0 g) was dissolved in EA (80 mL) at 85° C., and citric acid (525 mg, 2.73 mmol) was added under inert gas. The reaction mixture was stirred at 85° C. for another 3.5 hrs, then cooled to room temperature (RT), and n-Hexane (24 mL) was added. The white precipitate was filtered and dried to get the white solid HL-01-01.  1 H NMR (d 6 -DMSO, 400 MHz) δ 12.08 (br, 1H), 10.62 (br, 1H), 9.19 (br, 1H), 9.18 (s, 1H), 8.89 (s, 1H), 8.77 (s, 1H), 7.28-7.19 (m, 5H), 5.06 (m, 1H), 3.25 (d, 2H, J=6.8 Hz), 2.85 (m, 1H), 2.72 (m, 2H), 2.57 (m, 2H), 1.45 (m, 1H), 1.10 (m, 1H), 0.97 (m, 1H), 0.78 (d, 6H, J=4.4 Hz).  13 C NMR (d 6 -DMSO, 400 MHz) δ 177.82, 170.73, 170.62, 163.28, 147.84, 143.98, 143.71, 143.39, 129.28, 128.31, 126.79, 76.24, 50.31, 36.25, 24.55, 23.51, 21.38. 
       Example 2 
       [0172]    
       
                 
         
             
             
         
       
     
         [0173]    HL01-0 (100 mg) was dissolved in DMSO (2 mL), and L-malic acid (35 mg, 0.26 mmol) was added under inert gas. The reaction mixture was stirred at 95° C. for 6 hrs, then cooled to RT. The solvent was removed under reduced pressure, then EA/n-Hexane was added to the residue at −20° C. The white precipitate was filtered and dried to get the white solid, HL-01-02.  1 H NMR (d 6 -DMSO, 400 MHz) δ 12.30 (br, 1H), 10.72 (s, 1H), 9.33 (d, 1H, J=7.6 Hz), 9.13 (d, 1H, J=1.6 Hz), 8.89 (d, 1H, J=1.6 Hz), 8.78 (m, 1H), 7.28-7.21 (m, 5H), 5.07 (dd, 1H, J=15.2, 7.6 Hz), 4.37 (dd, 1H, J=7.2, 4.0 Hz), 3.46-3.42 (m, 1H), 3.29-3.20 (m, 2H), 2.63-2.28 (m, 2H), 1.46 (m, 1H), 1.17 (m, 2H), 0.81 (d, 6H, J=6.4 Hz). MS (m/z): [M+Na] calculated for C 23 H 27 BN 4 NaO 7 , 505.28. found, 505.19. 
       Example 3 
       [0174]    
       
                 
         
             
             
         
       
     
         [0175]    HL01-0 (200 mg) was dissolved in EA (8 mL) at 85° C., and diethanolamine (54.7 mg, 0.52 mmol) was added under inert gas. The reaction mixture was stirred at 85° C. for 6 hrs. then was cooled to RT. The white precipitate was collected and dried to get the white solid. (150 mg, 63.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.09 (s, 1H), 8.87 (d, 1H, J=2.4 Hz), 8.81 (d, 1H, J=8.8 Hz), 8.75 (s, 1H), 7.28-7.20 (m, 5H), 7.16-7.14 (m, 1H), 6.55 (br, 1H), 4.76 (td, 1H, J=9.2, 4.8 Hz), 3.69-3.61 (m, 2H), 3.28-3.23 (m, 1H), 3.48-3.41 (m, 1H), 3.16-3.04 (m, 3H), 2.85-2.77 (m, 1H), 2.74-2.67 (m, 2H), 1.63-1.53 (m, 1H), 1.37-1.30 (m, 1H), 1.22-1.16 (m, 1H), 0.80 (dd, 6H, J=12.8, 6.8 Hz). 
       Example 4 
       [0176]    
       
                 
         
             
             
         
       
     
         [0177]    HL01-0 (384 mg) was dissolved in DMSO (3 mL) and EA (3 mL), and Iminodiacetic Acid (133 mg, 1 mmol) was added under inert gas. The reaction mixture was stirred at 85° C. for 6 hrs, then was cooled to RT. The white precipitate was collected under reduced pressure, washed by EtOH, and dried to get the white solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.09 (d, 1H, J=1.2 Hz), 8.87 (d, 1H, J=2.4 Hz), 8.73-8.72 (m, 1H), 8.70 (d, 1H, J=8.8 Hz), 8.16 (br, 1H), 7.76 (d, 1H, J=8 Hz), 7.26-7.13 (m, 5H), 4.72 (td, 1H, J=8.8, 5.6 Hz), 4.06 (dd, 1H, J=17.2, 8.4 Hz), 3.92 (dd, 1H, J=17.6, 8.4 Hz), 3.76 (dd, 1H, J=9.2, 3.2 Hz), 3.72 (dd, 1H, J=9.2, 3.2 Hz), 3.14-3.01 (m, 3H), 1.59-1.45 (m, 2H), 1.08-1.01 (m, 1H), 0.82 (dd, 6H, J=22.4, 6.8 Hz). MS (m/z): [M+H] calculated for C 23 H 29 BN 5 O 6 , 482.32. found, 482.15. 
       Example 5 
       [0178]    
       
                 
         
             
             
         
       
     
         [0179]    HL01-0 (19.2 mg) was dissolved in DMSO (1.5 mL), and EDTA (7.3 mg, 0.05 mmol) was added under inert gas. The reaction mixture was stirred at 100° C. for 3 hrs, then was cooled to RT. The white precipitate was collected under reduced pressure, and dried get the white solid. MS (m/z): [M+H] calculated for C 29 H 38 BN 6 O 10 , 641.46. found, 641.30. 
       Example 6 
       [0180]    
       
                 
         
             
             
         
       
     
         [0181]    HL01-0 (50 mg) was dissolved in DMSO (2 mL), and EDTA (19 mg, 0.065 mmol) was added under inert gas. The reaction mixture was stirred at 105° C. for 4 hrs., then was cooled to RT. The white precipitate was collected under reduced pressure, purified by semi-prep RP-HPLC, and dried get the white solid. MS (m/z): [M+H] calculated for C 48 H 58 B 2 N 10 O 12 , 989.67. found, 989.2. 
       Example 7 
       [0182]    
       
                 
         
             
             
         
       
     
         [0183]    HL01-0 (200 mg) was dissolved in DMSO/EA (6 mL/6 mL), and N-methyliminodiacetic acid 133 mg, 0.52 mmol) as added under inert gas. The reaction mixture was stirred at 85° C. for 5 hrs, and then was cooled to RT. The white precipitate was collected under reduced pressure, and dried to get the white solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.07 (d, 1H, J=1.2 Hz), 8.92 (d, 1H, J=4.4 Hz), 8.87 (d, 1H, J=2.4 Hz), 8.74-8.73 (m, 1H), 7.30-7.23 (m, 5H), 7.20-7.15 (m, 1H), 4.70-4.64 (m, 1H), 4.22 (d, 1H, J=17.2 Hz), 4.07 (d, 1H, J=16.8 Hz), 3.98 (d, 1H, J=16.8 Hz), 3.57-3.51 (m, 2H), 3.09 (s, 1H), 3.07 (d, 1H, J=2.0 Hz), 2.82 (s, 3H), 1.59-1.53 (m, 1H), 1.43-1.36 (m, 1H), 1.22-1.16 (m, 1H), 0.84 (dd, 6H, J=11.2, 6.4 Hz). MS (m/z): [M+H] calculated for C 24 H 31 BN 5 O 6 , 496.34. found, 496.20. 
       Example 8 
       [0184]    
       
                 
         
             
             
         
       
     
         [0185]    HL01-0 (150 mg) was dissolved in DMSO (5 mL), and N-isopropyl iminodiacetic acid (HL01-12-0, 69 mg, 0.39 mmol) as added under inert gas. The reaction mixture was stirred at 85° C. for 5 hrs, and then was cooled to RT. The solvent was removed under reduced pressure to get colorless oil.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.09 (d, 1H, J=1.6 Hz), 8.91 (d, 1H, J=8.4 Hz), 8.86 (d, 1H, J=2.4 Hz), 7.44 (d, 1H, J=9.6 Hz), 7.30-7.16 (m, 5H), 4.68-4.62 (m, 1H), 4.28 (d, 1H, J=18.0 Hz), 3.89 (dd, 2H, J=18.4, 5.2 Hz), 3.71-3.61 (m, 3H), 3.09 (s, 1H), 3.07 (d, 1H, J=2.8 Hz), 1.61-1.55 (m, 1H), 1.49-1.42 (m, 1H), 1.16 (dd, 6H, J=6.0, 2.0 Hz), 0.99 (d, 1H, J=6.8 Hz), 0.84 (dd, 6H, J=29.2, 6.8 Hz). MS (m/z): [M+H] calculated for C 26 H 35 BN 5 O 6 , 524.4. found, 524.30. 
       Example 9 
       [0186]    
       
                 
         
             
             
         
       
     
         [0187]    HL01-0 (200 mg) was dissolved in DMSO (3 mL), and N-benzyl iminodiacetic acid (HL01-13-0, 122 mg, 0.547 mmol) as added under inert gas. The reaction mixture was stirred at 85° C. for 2 hrs, then was cooled to RT. The solvent was removed under reduced pressure to get colorless oil.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.12 (d, 1H, J=1.6 Hz), 9.06 (d, 1H, J=8.0 Hz), 8.87 (d, 1H, J=2.0 Hz), 8.75 (dd, 1H, J=2.4, 1.6 Hz), 7.63-7.61 (m, 1H), 7.52-7.50 (m, 2H), 7.34-7.17 (m, 7H), 4.66-4.60 (m, 1H), 4.465 (d, 1H, J=13.2 Hz), 4.26 (d, 1H, J=13.2 Hz), 4.18 (d, 1H, J=17.2 Hz), 3.85-3.77 (m, 2H), 3.68-3.63 (m, 1H), 3.15-3.00 (m, 3H), 1.66-1.60 (m, 1H), 1.56-1.45 (m, 1H), 1.35-1.26 (m, 1H), 0.89 (dd, 6H, J=11.2, 6.8 Hz). MS (m/z): [M+H] calculated for C 30 H 35 BN 5 O 6 , 572.44. found, 572.30. 
       Example 10 
       [0188]    
       
                 
         
             
             
         
       
     
         [0189]    HL01-0 (200 mg) was dissolved in EA (5 mL), and Pinacol (61.5 mg) was added under inert gas. The reaction mixture was stirred at 85° C. for 5 hrs, and then was cooled to RT, and the solvent was removed under reduced pressure to get the oil.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.18 (d, 1H, J=1.2 Hz), 8.99-8.98 (m, 1H), 8.94 (d, 1H, J=2.8 Hz), 8.84 (d, 1H, 8.4 Hz), 8.91-8.80 (m, 1H), 7.33-7.23 (m, 5H), 4.96-4.91 (m, 1H), 3.19-3.17 (m, 2H), 2.70-2.66 (m, 1H), 1.65-1.56 (m, 1H), 1.37-1.31 (m, 1H), 1.27-1.23 (m, 1H), 1.18 (d, 12H, J=4.8 Hz), 0.88 (t, 6H, J=6.4 Hz). MS (m/z): [M+H] calculated for C 25 H 36 BN 4 O 4 , 467.28. found: 467.30. 
       Example 11 
       [0190]    
       
                 
         
             
             
         
       
     
         [0191]    Chloroacetic acid (6 g, 0.0625 mol) was dissolved in water (20 mL) at 0° C., then neutralized with 5 N NaOH solution. Isopropylamine (1.85 g, 0.031 mol) was added to the solution and stirred at 50° C. overnight. BaCl 2  2H 2 O (7.6 g, 0.031 mol) was dissolved in hot water (15 mL) and was added to the reaction mixture. The precipitate was filtered and dried at 60° C. for 2 hours. The solid was dissolved in the boiling water, and 5N H 2 SO 4  was added. After removal of the precipitate, the filtrate was concentrated to give brown solid, HL01-12-0 (300 mg, 5.5%)  1 H NMR (d6-DMSO, 400 MHz) δ 3.27 (s, 4H), 3.12 (s, 1H), 1.02 (s, 6H). 
       Example 12 
       [0192]    
       
                 
         
             
             
         
       
     
         [0193]    Chloroacetic acid (18.9 g, 0.2 mol) was dissolved in water (30 mL) at 0° C., then neutralized with 5 N NaOH solution. Benzylamine (10.7 g, 0.1 mol) was added to the solution and stirred at 60° C. overnight. BaCl 2  2H 2 O (25.6 g, 0.105 mol) was dissolved in hot water (30 mL) and was added to the reaction mixture. The precipitate was filtered and dried at 80° C. for 4 hours. The solid was dissolved in the boiling water, and 5N H 2 SO 4  was added. After removal of the precipitate, the filtrate was concentrated to give white solid, HL01-13-0 (8.0 g, 36%).  1 H NMR (d6-DMSO, 400 MHz) δ 7.33-7.24 (m, 5H), 3.82 (s, 2H), 3.38 (s, 4H). 
       Example 13 
       [0194]    
       
                 
         
             
             
         
       
     
         [0195]    HL01-00 (30 mg, 0.083) was dissolved in DMSO (2 mL), and N-Methyl iminodiacetic acid (12.2 mg, 0.083 mmol) was added under inert gas. The reaction mixture was stirred at 85° C. for 2 hrs, then was cooled to RT. The solvent was removed under reduced pressure and the residue purified by Prep-HPLC to get the white solid, HL01-15 (15 mg, 38.5%) 1 H NMR (d6-DMSO, 400 MHz) δ 8.84 (s, 1H), 7.54-7.52 (m, 3H), 7.33 (d, 1H, J=8.8 Hz), 4.26-4.13 (m, 3H), 4.02-3.80 (m, 4H), 2.87 (s, 3H), 1.53-1.52 (m, 1H), 1.41-1.35 (m, 1H), 1.20-1.16 (m, 1H), 0.85 (m, 6H). MS (m/z): [M+H] calculated for C 19 H 25 BCl 2 N 3 O 6 , 472.12. found, 472.00. 
       Example 14 
       [0196]    
       
                 
         
             
             
         
       
     
         [0197]    HL01-000 (30 mg) was dissolved in DMSO (2 mL), and N-Methyl iminodiacetic acid (10.7 mg, 0.073 mmol) was added under inert gas. The reaction mixture was stirred at 85° C. for 2 hrs, then was cooled to RT. The solvent was removed under reduced pressure and the residue was purified by Prep-HPLC to get the white solid, HL01-17 (10 mg, 36.3%).  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.80 (d, 1H, J=8.4 Hz), 8.21-8.17 (m, 3H), 8.11 (t, 1H, J=8.0 Hz), 8.00 (d, 1H, J=6.8 Hz), 7.59-7.25 (m, 4H), 5.21-5.20 (m, 1H), 4.51 (dd, 1H, J=8.4, 3.6 Hz), 4.28 (d, 1H, J=17.6 Hz), 4.12 (d, 1H, J=16.8 Hz), 4.08 (br, 1H), 3.97 (d, 1H, J=17.2 Hz), 3.92 (d, 1H, J=16.4 Hz), 2.94 (s, 3H), 1.55-1.48 (m, 1H), 1.45-1.37 (m, 1H), 1.22-1.15 (m, 1H), 1.09 (d, 3H, J=6.0 Hz), 0.82 (dd, 6H, J=16.8, 6.8 Hz). MS (m/z): [M+H] calculated for C 26 H 34 BN 4 O 7 , 525.25. found, 525.30. 
       Example 15 
       [0198]    
       
                 
         
             
             
         
       
     
         [0199]    To a solution of HL01-00 (30 mg) in EA (2 mL) was added citric acid (16 mg, 0.083 mmol) at sealed tube. The reaction mixture was stirred at 85° C. for 1.5 hrs. The reaction mixture was cooled to RT, and the solid was filtered to get the product white solid, HL01-17. (˜15 mg, 35.7%) 1 H NMR (d 6 -DMSO, 400 MHz) δ 12.18 (br, 1H), 10.72 (s, 1H), 9.13 (s, 1H), 7.66 (s, 1H), 7.57 (d, 2H, J=1.2 Hz), 4.27 (br, 2H), 2.92-2.88 (m, 1H), 2.78-2.74 (m, 1H), 2.67-2.63 (m, 1H), 2.53 (s, 1H), 1.68-1.67 (m, 1H), 1.29-1.77 (m, 3H), 0.87 (d, 6H, J=6.4 Hz). 
       Example 16 
       [0200]    
       
                 
         
             
             
         
       
     
         [0201]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and then citrate (14 mg, 0.073 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 4 hrs, then cooled to RT, The solvent was removed to get solid (15 mg).  1 H NMR (d6-DMSO, 400 MHz) δ 12.14 (s, 1H), 10.78 (s, 1H), 8.81-8.79 (d, 1H, J=8.4 Hz), 8.24-8.19 (m, 3H), 8.15-8.11 (t, 1H), 8.04-8.03 (d, 1H, J=7.2 Hz), 7.58-7.49 (m, 3H), 5.7 (s, 1H), 4.72-4.69 (dd, 1H), 4.27 (s, 1H), 2.90-2.67 (m, 4H), 1.62 (s, 1H), 1.30-1.14 (d, 5H), 0.83-0.82 (d, 6H, J=6.4 Hz) 
       Example 17 
       [0202]    
       
                 
         
             
             
         
       
     
         [0203]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and then iminodiacetic acid (9.71 mg, 0.073 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get white crystalline solid, HL01-19(15 mg).  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.78-8.76 (d, 1H, J=8.0 Hz), 8.21-8.16 (m, 3H), 8.12-8.08 (t, 2H), 8.02-8.00 (d, 1H), 7.74-7.73 (d, 1H, J=7.6 Hz), 7.58-7.49 (m, 3H), 5.16 (s, 1H), 4.41-4.38 (q, 1H), 4.15-4.07 (m, 3H), 3.79-3.72 (m, 2H), 3.19-3.13 (m, 1H), 1.65-1.62 (m, 1H), 1.56-1.48 (m, 1H), 1.11-1.04 (m, 3H), 0.86-0.85 (d, 3H=6.8 Hz), 0.80-0.78 (d, 3H, J=6.4 Hz). MS (m/z): [M+H] calculated for C 25 H 32 BN 4 O 7 , 511.35. found, 511.0. 
       Example 18 
       [0204]    
       
                 
         
             
             
         
       
     
         [0205]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and Pinacol (8.61 mg, 0.073 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get solid, HL01-20 (10 mg).  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.11 (s, 1H), 8.78-8.76 (d, 1H, J=8.4 Hz), 8.23-8.19 (m, 3H), 8.13-8.10 (t, 1H), 8.03-8.01 (d, 1H, J=7.2 Hz), 7.57-7.50 (m, 4H), 5.32-5.31 (d, 1H, J=4.8 Hz), 4.55-4.51 (dd, 1H), 4.15-4.11 (dd, 1H), 1.68-1.64 (m, 1H), 1.29-1.20 (m, 2H), 1.14-1.09 (m, 12H), 0.85-0.83 (dd, 6H) 
       Example 19 
       [0206]    
       
                 
         
             
             
         
       
     
         [0207]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and N-isopropyl iminodiacetic (8.61 mg, 0.073 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, and then cooled to RT. The solvent was removed to get pale yellow sticky solid, HL01-21.  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.76-8.74 (d, 1H, J=8.4 Hz), 8.18-8.16 (m, 3H), 8.12-8.08 (t, 1H), 8.02-8.00 (d, 1H), 7.59-7.51 (m, 4H), 5.17 (s, 1H), 4.56-4.53 (dd, 1H), 4.33-4.28 (d, 1H), 4.08 (s, 1H), 3.99-3.89 (d, 3H), 3.83-3.80 (t, 1H), 3.71-3.67 (t, 1H), 1.59-1.37 (m, 3H), 1.23-1.10 (dd, 6H), 0.860.79 (m, 6H) MS (m/z): [M+H] calculated for C 28 H 38 BN 4 O 7 , 553.43. found, 553.3. 
       Example 20 
       [0208]    
       
                 
         
             
             
         
       
     
         [0209]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and EDTA (10.65 mg, 0.037 mmol) was added, the reaction mixture was stirred at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid which was purified by RP-HPLC to give HL01-220-1 and dimer HL01-22-2. HL01-22-1 MS (m/z): [M+H] calculated for C 31 H 41 BN 5 O 11 , 670.28. found, 670.2. HL01-22-2 MS (m/z): [M+H] calculated for C 52 H 65 B 2 N 8 O 14 , 1047.47. found, 1047.1. 
       Example 21 
       [0210]    
       
                 
         
             
             
         
       
     
         [0211]    HL01-000 (30 mg) was dissolved in DMSO (2 mL) at RT, and L-malic acid (9.79 mg, 0.073 mmol) was added, the reaction mixture was stirred at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d6-DMSO, 400 MHz) δ 12.30 (s, 1H), 10.87 (s, 1H), 8.83-8.81 (d, 1H, J=8 Hz), 8.24-8.02 (m, 5H), 7.59-7.52 (m, 3H), 5.77-5.76 (d, 1H, J=5.2 Hz), 4.76-4.73 (m, 1H), 4.41-4.39 (m, 1H), 4.32-4.29 (m, 1H), 2.68-2.57 (m, 2H), 1.63-1.56 (m, 1H), 1.31-1.26 (t, 2H), 1.19-1.18 (d, 3H, J=6.4 Hz), 0.84-0.83 (d, 6H, J=6.4 Hz) 
       Example 22 
       [0212]    
       
                 
         
             
             
         
       
     
         [0213]    HL01-00 (30 mg) was dissolved in DMSO (2 mL) at RT, and Iminodiacetic Acid (11.03 mg, 0.083 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d6-DMSO, 400 MHz) δ 8.75-8.72 (t, 1H), 8.19 (s, 1H), 7.69-7.68 (m, 1H), 7.52-7.51 (d, 2H, J=1.2 Hz), 4.15-4.0 (m, 2H), 3.88-3.72 (m, 4H), 3.14-3.08 (m, 1H), 1.65-1.62 (m, 1H), 1.54-1.46 (m, 1H), 1.12-1.06 (m, 1H), 0.88-0.81 (dd, 6H, J=6.8, 21.6 Hz). MS (m/z): [M+H] calculated for C18H22BCl2N3O6, 458.09. found, 458.4. 
       Example 23 
       [0214]    
       
                 
         
             
             
         
       
     
         [0215]    HL01-00 (30 mg) was dissolved in EA (2 mL) at RT, and pinacol (9.79 mg, 0.083 mmol) was added. The reaction mixture was stiffed at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.07 (s, 1H), 8.88-8.85 (t, 1H), 7.70 (s, 1H), 7.53 (s, 2H), 4.04-4.02 (d, 2H, J=6 Hz), 2.66-2.57 (m, 1H), 1.71-1.67 (m, 2H), 1.52-1.47 (m, 1H), 1.08 (s, 12H), 0.87-0.84 (t, 6H) 
       Example 24 
       [0216]    
       
                 
         
             
             
         
       
     
         [0217]    HL01-00 (30 mg) was dissolved in DMSO (1 mL) at RT, and N-isopropyl iminodiacetic acid (14.53 mg, 0.083 mmol) was added. The reaction mixture was stirred at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.78 (s, 1H), 7.68 (s, 1H), 7.49-7.47 (d, 3H, J=8 Hz), 4.32-4.28 (d, 1H, J=16.8 Hz), 4.05-3.88 (m, 4H), 3.74-3.67 (m, 3H), 1.54 (s, 1H), 1.44-1.38 (t, 2H), 1.23-1.06 (m, 7H), 0.86-0.82 (d, 6H, J=15.2 Hz). MS (m/z): [M+H] calculated for C 21 H 29 BCl 2 N 3 O 6 , 501.18. found, 502.1. 
       Example 25 
       [0218]    
       
                 
         
             
             
         
       
     
         [0219]    HL01-00 (30 mg) was dissolved in DMSO (1 mL) at RT, and EDTA (24.23 mg, 0.083 mmol) was added. The reaction mixture was stiffed at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid which was purified by RP-HPLC to obtain HL01-27-1 and dimer HL01-27-2. HL01-27-1 
         [0220]    MS (m/z): [M+H] calculated for C 24 H 32 BCl 2 N 4 O 10 , 618.24. found, 618.4; HL01-27-2. 
         [0221]    MS (m/z): [M+H] calculated for C 38 H 47 B 2 C 14 N 6 O 12 , 943.24. found: 943.4. 
       Example 26 
       [0222]    
       
                 
         
             
             
         
       
     
         [0223]    HL01-00 (30 mg) was dissolved in DMSO (1 mL) at RT, and L-malic acid (11.12 mg, 0.083 mmol) was added. The reaction mixture was stirred at 98° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 4 -CD 3 OD, 400 MHz) δ 7.59-7.56 (t, 2H), 7.46 (dd, 1H, J=2 Hz, 8.4 Hz), 4.591-4.565 (q, 1H), 4.37 (s, 2H), 2.87-2.78 (m, 2H), 2.61-2.58 (m, 1H), 1.74-1.64 (m, 1H), 1.47-1.43 (t, 2H), 0.96-0.94 (dd, 6H, J=2.8 Hz, 6.8 Hz) 
       Example 27 
       [0224]    
       
                 
         
             
             
         
       
     
         [0225]    HL01-00 (30 mg) was dissolved in DMSO (1 mL) at RT, and Nitrilotri-acetic acid (15.85 mg, 0.083 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.81-8.78 (t, 1H), 7.69-7.68 (t, 1H), 7.50-7.38 (m, 3H), 4.43-4.38 (d, 1H, J=20 Hz), 4.30-4.25 (d, 1H, J=16.8 Hz), 4.21-4.00 (m, 4H), 3.91-3.86 (dd, 1H, J=5.2 Hz, 15.6 Hz), 3.68-3.63 (dd, 1H, J=6.4 Hz, 16 Hz), 3.59-3.53 (m, 1H), 1.56-1.53 (m, 1H), 1.39-1.36 (m, 1H), 1.21-1.17 (m, 1H), 0.85 (dd, 6H, J=6.4 Hz, 14 Hz). MS (m/z): [M+H] calculated for C 20 H 25 BCl 2 N 3 O 8 , 517.14. found, 517.3. 
       Example 28 
       [0226]    
       
                 
         
             
             
         
       
     
         [0227]    HL01-000 (30 mg) was dissolved in DMSO (1 mL) at RT, and Nitrilotri-acetic acid (13.94 mg, 0.073 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.83-8.78 (t, 1H), 8.22-8.18 (t, 2H), 8.12-8.08 (t, 1H), 8.03-7.98 (t, 1H), 7.59-7.48 (m, 5H), 4.53-4.50 (m, 1H), 4.46-4.42 (d, 1H, J=17.6 Hz), 4.35-4.02 (m, 4H), 3.61-3.55 (m, 1H), 3.50 (s, 2H), 1.55-1.46 (m, 1H), 1.45-1.38 (m, 2H), 1.10-1.08 (d, 3H, J=6.4 Hz), 0.85-0.79 (m, 6H). MS (m/z): [M+H] calculated for C 27 H 34 BN 4 O 9 , 569.38. found, 569.5. 
       Example 29 
       [0228]    
       
                 
         
             
             
         
       
     
         [0229]    HL01-0 (30 mg) was dissolved in DMSO (1 mL) at RT, and Nitrilotriacetic acid (14.89 mg, 0.078 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 6 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d6-DMSO, 400 MHz) δ 9.07-9.06 (d, 1H, J=1.2 Hz), 8.92-8.83 (m, 2H), 8.74-8.70 (m, 1H), 7.40-7.38 (d, 1H, J=10 Hz), 7.29-7.12 (m, 5H), 4.71-4.65 (m, 1H), 4.40-4.04 (m, 4H), 3.55-3.55 (m, 3H), 3.09-3.06 (m, 2H), 1.60-1.51 (m, 1H), 1.45-1.38 (m, 1H), 1.23-1.17 (m, 1H), 0.84 (dd, 6H, J=6.4 Hz, 18.4 Hz). MS (m/z): [M+H] calculated for C 25 H 31 BN 5 O 8 , 540.35. found, 540.3. 
       Example 30 
       [0230]    
       
                 
         
             
             
         
       
     
         [0231]    HL01-0 (30 mg) was dissolved in DMSO (1 mL) at RT, and L(+)-tartaric acid (11.70 mg, 0.078 mmol) was added, The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT, The solvent was removed to get solid.  1 H NMR (d6-DMSO, 400 MHz) δ12.75 (bs, 1H), 10.77 (s, 1H), 9.38-9.35 (t, 1H), 9.12 (s, 1H), 8.90-8.89 (d, 1H, J=2.4 Hz), 8.78-8.77 (t, 1H), 7.29-7.18 (m, 5H), 5.12-5.07 (q, 1H), 4.49-4.21 (q, 2H), 3.32-3.21 (m, 2H), 2.68-2.57 (m, 1H), 1.55-1.37 (m, 1H), 1.23-1.06 (m, 2H), 0.86-0.79 (q, 6H). 
       Example 31 
       [0232]    
       
                 
         
             
             
         
       
     
         [0233]    HL01-0 (60 mg) was dissolved in Ethyl acetate (1 mL) at RT, and N-methyldiethanolamine (18.56 mg, 0.156 mmol) was added. The reaction mixture was stirred at RT under inert gas for another 5 hrs, then solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.24-9.22 (d, 1H, J=8.4 Hz), 9.09-9.08 (d, 1H, J=1.2 Hz), 8.89-8.88 (d, 1H, J=2.4 Hz), 8.79-8.78 (m, 1H), 7.30-7.12 (m, 5H), 6.74-6.72 (d, 1H, J=10 Hz), 4.67-4.61 (m, 1H), 3.61-3.55 (m, 3H), 3.21-3.0 (m, 6H), 2.90-2.86 (m, 1H), 1.55-1.49 (m, 1H), 1.23-1.15 (m, 2H), 0.84-0.78 (dd, 6H, J=6.4, 16 Hz). 3H (N-Me) was contained in 2.5 (DMSO) 
       Example 32 
       [0234]    
       
                 
         
             
             
         
       
     
         [0235]    HL01-0 (30 mg) was dissolved in DMSO (1 mL) at RT, and N-ethyl-iminodiacetic acid (12.57 mg, 0.078 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 9.12-9.08 (m 1H), 8.93-8.84 (m, 2H), 8.74-8.66 (m, 1H), 7.35-7.12 (m, 5H), 4.93-4.87 (q, 1H), 4.81-4.75 (q, 1H), 4.71-4.65 (q, 1H), 4.18-3.93 (m, 4H), 3.30-3.24 (q, 1H), 3.14-3.03 (m, 2H), 1.56-1.49 (m, 1H), 1.41-1.25 (m, 2H), 1.22-1.13 (m, 3H), 0.86-0.74 (m, 6H). 
       Example 33 
       [0236]    
       
                 
         
             
             
         
       
     
         [0237]    HL01-00 (30 mg) was dissolved in ethyl acetate (1 mL) at RT, and N-methyldiethanolamine (9.87 mg, 0.083 mmol) was added, then the reaction mixture was stirred at RT under inert gas for another 5 hrs. The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ 8.94-8.91 (t, 1H), 7.72 (s, 1H), 7.56-7.45 (m, 1H,), 6.51-6.48 (d, 1H, J=9.6 Hz), 3.77-3.62 (m, 6H), 3.20-3.11 (m, 3H), 2.94-2.91 (m, 1H), 2.85-2.81 (m, 1H), 2.59 (s, 3H), 1.49 (s, 1H), 1.22-1.17 (m, 2H), 0.84-0.79 (dd, 6H, J=6, 16.8 Hz). MS (m/z): [M+H] calculated for C 19 H 29 BCl 2 N 3 O 4 , 445.16. found, 445.4. 
       Example 34 
       [0238]    
       
                 
         
             
             
         
       
     
         [0239]    HL01-00 (30 mg, 0.078 mmol) was dissolved in DMSO (1 mL) at RT, and N-ethyl-iminodiacetic acid (12.57 mg, 0.078 mmol) was added. The reaction mixture was stirred at 85° C. under inert gas for another 5 hrs, then cooled to RT, The solvent was removed to get solid.  1 H NMR (d 6 -DMSO, 400 MHz) δ8.78-8.66 (dt, 1H), 7.69 (s, 1H), 7.52-7.44 (m, 2H), 7.35-7.29 (m, 1H), 4.19-3.82 (m, 6H), 3.18-3.09 (m, 2H), 2.99 (s, 1H), 1.61-1.43 (m, 1H), 1.38-1.28 (m, 2H), 1.20-1.11 (m, 3H), 0.87-0.82 (m, 6H). 
         [0240]    In addition to the foregoing, the above reaction schemes, and variations thereof, can be used to prepare the compounds set forth in the following table: 
         [0000]    
       
         
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                   
                 Serial # 
                 Structure 
                 Name 
               
               
                   
               
             
             
               
                   
                 HL-40 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl (S)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-41 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl 2-((S)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-42 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl (S)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-43 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl 2-((S)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-44 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl (4S,4′S)-bis(2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate) 
               
               
                   
               
               
                   
                 HL-45 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl bis(2- ((S)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate) 
               
               
                   
               
               
                   
                 HL-46 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl bis(2- ((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl(acetate) 
               
               
                   
               
               
                   
                 HL-47 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl bis(2- ((S)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate) 
               
               
                   
               
               
                   
                 HL-48 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl(4S,4′S)- bis(2-((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate) 
               
               
                   
               
               
                   
                 HL-49 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl (4S,4′S)-bis(2-((R)-1- (2-(2,5- dichlorohenzamido) acetamido)-3- methylbutyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate) 
               
               
                   
               
               
                   
                 HL-50 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl 2-((S)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-51 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-tert-butyl 2-((R)-1- (2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-52 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl (S)-2-((R)-1- (2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-53 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl 2-((S)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-54 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-methyl 2-((R)-1-(2- (2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-55 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl 2-((S)-2-((R)-1- (2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetale 
               
               
                   
               
               
                   
                 HL-56 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-methyl 2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-57 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-58 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-isopropyl 2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-59 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl 2-((S)-2-((R)- 1-((2S,3R)-3-hydroxy- 2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-60 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-tert-butyl 2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-61 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl 2-((S)-2-((R)- 1-((2S,3R)-3-hydroxy- 2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-62 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-63 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-64 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)-4- (isopropylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-65 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)-4- (2-(isopropylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-66 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)-4- (tert-butylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-67 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)-4- (2-(tert-butylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-68 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N,N-ethane-1,2-diyl (4R,4′R)-bis(2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxamide) 
               
               
                   
               
               
                   
                 HL-69 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N,N-ethane-1,2-diyl bis(2-((R)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propananiido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetamide) 
               
               
                   
               
               
                   
                 HL-70 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-N- methyl-6-oxo-1,3,2- dioxaborinane-4- carboxamide 
               
               
                   
               
               
                   
                 HL-71 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-72 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- N-isopropyl-6-oxo- 1,3,2-dioxaborinane-4- carboxamide 
               
               
                   
               
               
                   
                 HL-73 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-4-(2- (isopropylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-74 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-N-(tert-butyl)-2- ((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxamide 
               
               
                   
               
               
                   
                 HL-75 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(2-(((R)-1-((R)-4-(2- (tert-butylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)-2,5- dichlorobenzamide 
               
               
                   
               
               
                   
                 HL-76 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (4R,4′R)-N,N′-(ethane- 1,2-diyl)bis(2-((R)-1-(2- (2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxamide) 
               
               
                   
               
               
                   
                 HL-77 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N,N-ethane-1,2-diyl bis(2-((R)-2-((R)-1-(2- (2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetamide) 
               
               
                   
               
               
                   
                 HL-78 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N,N-ethane-1,2- diyl(4R,4′R)-bis(2-((R)- 1-((2S,3R)-3-hydroxy- 2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxamide) 
               
               
                   
               
               
                   
                 HL-79 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N,N-ethane-1,2-diyl (4R,4′R)-bis(2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxamide) 
               
               
                   
               
               
                   
                 HL-80 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-81 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-82 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-1-((R)-4- (isopropylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-2-yl)-3- methylbutyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-83 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-1-((R)-4-(2- (isopropylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-84 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-4-(tert- butylcarbamoyl)-6-oxo- 1,3,2-dioxaborinan-2- yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-85 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-4-(2-(tert- butylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-86 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl (R)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-87 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-88 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl 2-((R)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-89 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl (R)-2-((R(-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-90 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 isopropyl 2-((R)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-91 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl (R)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-92 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 tert-butyl 2-((R)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-93 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl (4R,4′R)-bis(2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido (propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate) 
               
               
                   
               
               
                   
                 HL-94 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 ethane-1,2-diyl (4R,4′R)-bis(2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido(butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate) 
               
               
                   
               
               
                   
                 HL-95 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-96 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-97 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-98 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-99 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4- (methoxycarbonyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid  
               
               
                   
               
               
                   
                 HL-100 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (methoxycarbonyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido(butyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-101 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-102 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-103 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-104 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2-methoxy-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-105 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (methoxycarbonyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid  
               
               
                   
               
               
                   
                 HL-106 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4- (methoxycarbonyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido (propanamido)butyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-107 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-108 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-109 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-110 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-111 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-112 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-113 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-114 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-115 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-116 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-methoxy-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-117 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-118 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 4-(methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-119 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamide) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-5- oxo-1,3,2-dioxaborolan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-120 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-5- oxo-1,3,2-dioxaborolan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-121 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-((2S,3R)- 3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-122 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-123 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-124 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-125 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-5- oxo-1,3,2-dioxaborolan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-126 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-5- oxo-1,3,2-dioxaborolan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-127 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-128 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- methoxy-2-oxoethyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-129 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-130 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methoxycarbonyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-131 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-132 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-133 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-134 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-135 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-136 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-137 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-138 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-139 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-140 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)- 4-(2-(methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-141 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-142 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-143 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-144 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-145 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-146 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-147 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 4-(methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-148 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-149 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-150 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-151 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-152 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-153 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-154 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-155 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-156 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-157 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-158 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamide) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-159 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-160 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-161 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-162 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-5-oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-163 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6-- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-164 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-4-(2- (methylamino)-2- oxoethyl)-6-oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-165 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methylcarbamoyl )-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-166 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-4- (methylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 4-yl)acetic acid 
               
               
                   
               
               
                   
                 HL-167 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-168 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-169 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-170 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-171 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4- (dimethylcarbamoyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-172 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (dimethylcarbamoyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-173 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-174 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-175 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-176 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-177 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (dimethylcarbamoyl)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-178 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,2′-(2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolane-4,4- diyl)bis(N,N- dimethylacetamide) 
               
               
                   
               
               
                   
                 HL-179 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)-4- (2-(dimethylamino)-2- oxoethyl)-4- (dimethylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-180 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((S)-4- (2-(dimethylamino)-2- oxoethyl)-4- (dimethylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-181 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-182 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-5-oxo- 1,3,2-dioxaborolan-4- yl acetic acid 
               
               
                   
               
               
                   
                 HL-183 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-184 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-185 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 4-(dimethylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-186 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(dimethylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-187 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-188 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-189 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-190 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-4-(2- (dimethylamino)- 2-oxoethyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-191 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(dimethylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-192 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(dimethylcarbamoyl)- 6-oxo-1,3,2- dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-193 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,2′-(2-(1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-5-oxo-1,3,2- dioxaborolane-4,4- diyl)bis(N,N- dimethylacetamide) 
               
               
                   
               
               
                   
                 HL-194 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,2′-(2-(1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)-5-oxo-1,3,2- dioxaborolane-4,4- diyl)bis(N,N- dimethylacetamide) 
               
               
                   
               
               
                   
                 HL-195 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-(dimethylamino)- 2-oxoethyl)-N,N- dimethyl-6-oxo-1,3,2- dioxaborinane-4- carboxamide 
               
               
                   
               
               
                   
                 HL-196 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 4-(2-(dimethylamino)- 2-oxoethyl)-N,N- dimethyl-6-oxo-1,3,2- dioxaborinane-4- carboxamide 
               
               
                   
               
               
                   
                 HL-197 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-198 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-199 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-200 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-201 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4- (dimethylcarbamoyl)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-202 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (dimethylcarbamoyl)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- l,3,2-dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-203 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-204 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-205 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-206 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (S)-4-(2- (dimethylamino)-2- oxoethyl)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6-phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylic acid 
               
               
                   
               
               
                   
                 HL-207 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((S)-4- (dimethylcarbamoyl)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-208 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2-((R)-4- (dimethylcarbamoyl)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinan-4- yl)acetic acid 
               
               
                   
               
               
                   
                 HL-209 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,2′-(2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinarnido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolane- 4,4-diyl)bis(N,N- dimethylacetamide) 
               
               
                   
               
               
                   
                 HL-210 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,2′-(2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolane- 4,4-diyl)bis(N,N- dimethylacetamide) 
               
               
                   
               
               
                   
                 HL-211 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-4-(2- (dimethylamino)-2- oxoethyl)-4- (dimethylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-212 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((S)-4-(2- (dimethylamino)-2- oxoethyl)-4- (dimethylcarbamoyl)-6- oxo-1,3,2-dioxaborinan- 2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-213 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- hydroxy-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-214 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- hydroxy-2-((R)-3- methyl-1-((S)-3-phenyl- 2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-215 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-hydroxy- 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-216 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-hydroxy- 2-((R)-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-217 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-hydroxy-6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-218 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-hydroxy-6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-219 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-hydroxy-6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-220 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4-yl)-2- hydroxyacetate 
               
               
                   
               
               
                   
                 HL-222 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- hydroxy-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-223 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- hydroxy-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-224 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-hydroxy- 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-225 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-hydroxy- 2-((R)-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl )-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-226 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- amino-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-227 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- amino-2-((R)-3-methyl- 1-((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-228 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-229 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-230 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- amino-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-231 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- amino-2-((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 6-oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-232 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-233 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-234 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- amino-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-235 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- amino-2-((R)-1- ((2S,3R)-3-hydroxy-2- (6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-236 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-237 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-amino-2- ((R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-238 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-5- (methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-239 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-2-((R)- 3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-5- (methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-240 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4-yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-241 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4-yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-242 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-(methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-243 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-(methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-244 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4-yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-245 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-(2-(2,5- dichlorobenzamido)acet amido)-3-methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4-yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-246 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-2-((R)- 1-((2S,3R)-3-hydroxy- 2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5- (methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-247 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-2-((R)- 1-((2S,3R)-3-hydroxy- 2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5- (methylamino)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-248 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6 phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- l,3,2-dioxaborolan-4- yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-249 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)-2- (methylamino)acetate 
               
               
                   
               
               
                   
                 HL-250 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- (dimethylamino)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-251 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- (dimethylamino)-2- ((R)-1-((2S,3R)-3- hydroxy-2-(6 phenylpicolinamido) butanamido)-3- methylbutyl)-6-oxo- 1,3,2-dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-252 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2- (dimethylamino)-2- ((R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-253 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2- (dimethylamino)-2- ((R)-2-((R)-1-((2S,3R)- 3-hydroxy-2-(6- phenylpicolinamido) butanamido)-3- methylbutyl)-5-oxo- 1,3,2-dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-254 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,SR)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-(dimethylamino)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-255 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-2-((R)- 1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-(dimethylamino)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-256 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4-yl)-2- (dimethylamino)acetate 
               
               
                   
               
               
                   
                 HL-257 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2-((R)-2- ((R)-1-(2-(2,5- dichlorobenzamido) acetamido)-3- methylbutyl)- 5-oxo-1,3,2- dioxaborolan-4-yl)-2- (dimethylamino)acetate 
               
               
                   
               
               
                   
                 HL-258 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5R)-5- (dimethylamino)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-259 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (4R,5S)-5- (dimethylamino)-2- ((R)-3-methyl-1-((S)-3- phenyl-2-(pyrazine-2- carboxamido) propanamido)butyl)-6- oxo-1,3,2- dioxaborinane-4- carboxylate 
               
               
                   
               
               
                   
                 HL-260 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2- (dimethylamino)-2- ((R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-261 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 methyl (R)-2- (dimethylamino)-2- ((R)-2-((R)-3-methyl-1- ((S)-3-phenyl-2- (pyrazine-2- carboxamido) propanamido)butyl)-5- oxo-1,3,2- dioxaborolan-4- yl)acetate 
               
               
                   
               
               
                   
                 HL-262 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 5,6-dimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-263 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-5,6-dimethyl- 4,8-dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-264 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-5,6-dimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-265 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-((R)-1-((R)- 5,6-dimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-266 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-5,6-dimethyl- 4,8-dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-267 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-5,6-dimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-268 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7R)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-269 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7R)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-270 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7R)-5,6,7- trimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-271 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7S)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-272 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7S)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-273 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7S)-5,6,7- trimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-274 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7R)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-275 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7R)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-276 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7R)-5,6,7- trimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amido)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-277 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7S)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-278 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7S)- 5,6,7-trimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-279 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7S)-5,6,7- trimethyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-280 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-281 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-282 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa-11- aza-4-borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6 phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-283 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-11- methyl-2,6-dioxo-3,5- dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-284 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 11-methyl-2,6-dioxo- 3,5-dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-285 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-11-methyl- 2,6-dioxo-3,5-dioxa-11- aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-286 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5- dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-287 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5- dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-288 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-3,5-dioxa-11-aza- 4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-289 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-290 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-291 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa-11- aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-292 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5,9- trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-293 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5,9-trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-294 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5,9-trioxa- 11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-295 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-11- methyl-2,6-dioxo-3,5,9- trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-296 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 11-methyl-2,6-dioxo- 3,5,9-trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-297 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-11-methyl- 2,6-dioxo-3,5,9-trioxa- 11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-298 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5,9- trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-299 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5,9- trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-300 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-3,5,9-trioxa-11- aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-301 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5,9- trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide  
               
               
                   
               
               
                   
                 HL-302 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5,9-trioxa-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-303 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5,9-trioxa- 11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-304 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-305 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-306 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-307 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-11- methyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-308 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 11-methyl-2,6-dioxo- 3,5-dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-309 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-11-methyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-310 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-311 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2- (((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-312 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-313 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-314 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-315 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-316 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9-thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-317 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-9-thia-11-aza- 4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-318 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa-9- thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenyl)picolinamide 
               
               
                   
               
               
                   
                 HL-319 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9-thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-320 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1S,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9-thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-321 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-3,5-dioxa-9-thia- 11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-322 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-11- methyl-2,6-dioxo-3,5- dioxa-9-thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-323 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 11-methyl-2,6-dioxo- 3,5-dioxa-9-thia-11-aza- 4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-324 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-11-methyl- 2,6-dioxo-3,5-dioxa-9- thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-325 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-3,5- dioxa-9-thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-326 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo- 3,5-dioxa-9-thia-11-aza- 4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-327 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-3,5-dioxa-9- thia-11-aza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-328 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-10- methyl-2,6-dioxo-3,5- dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-329 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 10-methyl-2,6-dioxo- 3,5-dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-330 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-10-methyl- 2,6-dioxo-3,5-dioxa-10- aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-331 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-10- methyl-2,6-dioxo-3,5- dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-332 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 10-methyl-2,6-dioxo- 3,5-dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-333 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-10-methyl- 2,6-dioxo-3,5-dioxa-10- aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-334 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-10- methyl-2,6-dioxo-3,5- dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-335 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 10-methyl-2,6-dioxo- 3,5-dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-336 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-10-methyl- 2,6-dioxo-3,5-dioxa-10- aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-337 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-10- methyl-2,6-dioxo-3,5- dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-338 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1S,7S)-10- methyl-2,6-dioxo-3,5- dioxa-10-aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-339 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-10-methyl- 2,6-dioxo-3,5-dioxa-10- aza-4- borabicyclo[5.2.1]decan- 4-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide  
               
               
                   
               
               
                   
                 HL-340 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((1R,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-341 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((1R,7S)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-342 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((1R,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-343 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((1R,7R)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-344 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((1R,7R)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide  
               
               
                   
               
               
                   
                 HL-345 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((1R,7R)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxo-3- phenylpropan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-346 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((1S,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-347 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((1S,7S)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-348 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((1S,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-349 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((1R,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-350 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((1R,7S)-9,11- dimethyl-2,6-dioxo-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-351 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((1R,7S)-9,11-dimethyl- 2,6-dioxo-3,5-dioxa- 9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-352 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-353 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-354 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-9-phenyl-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-355 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7R)-11- methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-356 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7R)- 11-methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-357 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7R)-11-methyl- 2,6-dioxo-9-phenyl-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamde 
               
               
                   
               
               
                   
                 HL-358 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1S,7S)-11- methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-359 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1S,7S)-11- methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide  
               
               
                   
               
               
                   
                 HL-360 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1S,7S)-11-methyl-2,6- dioxo-9-phenyl-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-361 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((1R,7S)-11- methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-362 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((1R,7S)- 11-methyl-2,6-dioxo-9- phenyl-3,5-dioxa-9,11- diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-363 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((1R,7S)-11-methyl- 2,6-dioxo-9-phenyl-3,5- dioxa-9,11-diaza-4- borabicyclo[5.3.1] undecan-4-yl)butyl) amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-364 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-(4,8- dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-365 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((1-(4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-366 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- (4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-367 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-368 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-369 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- trioxaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-370 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-371 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-5- methyl-4,8-dioxo- l,3,6,2-trioxaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-372 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- trioxaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-373 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-374 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7S)-5,7- dimethyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-375 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-376 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-377 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2 yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-378 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-379 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-380 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7S)-5,7- dimethyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-381 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-382 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-383 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4,8-dioxo- 1,3,6,2-trioxaborocan-2- yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-384 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- trioxaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-385 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-(4,8- dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-386 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((1-(4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-387 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- (4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-388 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-389 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-((S)-1- (((R)-3-methyl-1-((R)- 5-methyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)benzamide 
               
               
                   
               
               
                   
                 HL-390 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-391 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-392 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide  
               
               
                   
               
               
                   
                 HL-393 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-394 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-395 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7S)-5,7- dimethyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-396 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-397 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-398 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-399 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-400 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-401 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7S)-5,7- dimethyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-402 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7S)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-403 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-404 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-405 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4,8-dioxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-406 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(4-oxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-407 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(4-oxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-408 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(4- oxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-409 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-410 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-411 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-7-methyl-4-oxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-412 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-413 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-414 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- dioxathiaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-415 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-416 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5S,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-417 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-418 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-419 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-420 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-421 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-422 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5S,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-423 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-424 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 1-oxo-3-phenylpropan- 2-yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-425 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-426 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxathiaborocan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-427 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-428 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(4-oxo- 1,3,6,2-dioxazaboracan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-429 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(4- oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-430 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-431 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-432 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-7-methyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-433 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((R)-7- methyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-434 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((R)-5- methyl-4,8-dioxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-435 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((R)-5-methyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-436 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-437 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5S,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-438 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-439 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-440 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-441 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-442 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-443 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5S,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-444 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5S,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-445 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-446 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((5R,7R)-5,7- dimethyl-4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-447 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((5R,7R)-5,7-dimethyl- 4-oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-448 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(6-methyl-4- oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-449 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(6-methyl- 4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-450 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(6- methyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-451 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 6,7-dimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-452 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-6,7-dimethyl-4- oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-453 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-6,7-dimethyl-4- oxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-454 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 6,7-dimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-455 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-5,6-dimethyl- 4,8-dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-456 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-5,6-dimethyl-4,8- dioxo-1,3,6,2- dioxazaborocan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-457 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5S,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-458 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5S,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-459 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5S,7R)-5,6,7- trimethyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-460 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-461 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-462 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7R)-5,6,7- trimethyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-463 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5S,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-464 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5S,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-465 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5S,7R)-5,6,7- trimethyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-466 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-467 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7R)- 5,6,7-trimethyl-4-oxo- 1,3,6,2-dioxazaborocan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-468 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7R)-5,6,7- trimethyl-4-oxo-1,3,6,2- dioxazaborocan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-469 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((2R,3R)- 2,3,4-trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-470 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((2R,3R)- 2,3,4-trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-471 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((2R,3R)-2,3,4- trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-472 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((2R,3R,5S)- 2,3,4,5-tetramethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-473 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1- ((2R,3R,5S)-2,3,4,3- tetramethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-474 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((2R,3R,5S)-2,3,4,5- tetramethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-475 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((2S,3R,5R)-4-ethyl- 2,3,5-trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-476 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-((S)-1- (((R)-1-((2S,3R,5R)-4- ethyl-2,3,5-trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)benzamide 
               
               
                   
               
               
                   
                 HL-477 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1- ((2S,3R,5R)-4-ethyl- 2,3,5-trimethyl-6- oxotetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)-6-phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-478 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(6-methyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-479 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(6-methyl- 4,9-dioxo-1,3,6,2- dioxazaboronan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-480 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(6- methyl-4,9-dioxo- 1,3,6,2-dioxazaboronan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-481 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 5,6-dimethyl-4,9-dioxo- 1,3,6,2-dioxazaboronan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-482 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-5,6-dimethyl- 4,9-dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide  
               
               
                   
               
               
                   
                 HL-483 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-5,6-dimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-484 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-((5R,7S)- 5,6,7-trimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-485 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 3-methyl-1-((5R,7S)- 5,6,7-trimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-486 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1- ((5R,7S)-5,6,7- trimethyl-4,9-dioxo- 1,3,6,2-dioxazaboronan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-487 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 6,8-dimethyl-4,9-dioxo- 1,3,6,2-dioxazaboronan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-488 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-6,8-dimethyl- 4,9-dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-489 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-6,8-dimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-490 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((S)- 6,7-dimethyl-4,9-dioxo- 1,3,6,2-dioxazaboronan- 2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-491 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((S)-6,7-dimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 2-oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-492 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((S)-6,7-dimethyl-4,9- dioxo-1,3,6,2- dioxazaboronan-2-yl)- 3-methylbutyl)amino)- 3-hydroxy-1-oxobutan- 2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-493 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(7-methyl- 4,10-dioxo-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-494 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(7-methyl- 4,10-dioxo-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-495 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(7- methyl-4,10-dioxo- 1,3,7,2-dioxazaborecan- 2-yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-496 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-((R)- 6,7-dimethyl-4,10- dioxo-1,3,7,2- dioxazaborecan-2-yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-497 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2,5-dichloro-N-(2-(((R)- 1-((R)-6,7-dimethyl- 4,10-dioxo-1,3,7,2- dioxazaborecan-2-yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-498 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-(((R)-1- ((R)-6,7-dimethyl-4,10- dioxo-1,3,7,2- dioxazaborecan-2-yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-499 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(7-methyl-4- oxo-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-1-oxo- 3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-500 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(7-methyl- 4-oxo-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-501 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(7- methyl-4-oxo-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-502 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-3- methyl-1-(7-methyl- 1,3,7,2-dioxazaborecan- 2-yl)butyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-503 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((3-methyl-1-(7-methyl- 1,3,7,2-dioxazaborecan- 2-yl)butyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-504 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-3-hydroxy- 1-(((R)-3-methyl-1-(7- methyl-1,3,7,2- dioxazaborecan-2- yl)butyl)amino)-1- oxobutan-2-yl)-6- phenylpicolinamide 
               
               
                   
               
               
                   
                 HL-505 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((S)-1-(((R)-1-(4- ethyltetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-1- oxo-3-phenylpropan-2- yl)pyrazine-2- carboxamide 
               
               
                   
               
               
                   
                 HL-506 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 (R)-2,5-dichloro-N-(2- ((1-(4-ethyltetrahydro- 2H-414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-2- oxoethyl)benzamide 
               
               
                   
               
               
                   
                 HL-507 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-((2S,3R)-1-((R)-1- (4-ethyltetrahydro-2H- 414,814- [1,3,2]oxazaborolo[2,3- b][1,3,2]oxazaborol-8- yl)-3- methylbutyl)amino)-3- hydroxy-1-oxobutan-2- yl)-6- phenylpicolinamide 
               
               
                   
               
             
          
         
       
     
       Stability Study 
       [0241]    Compounds were tested for their stability, under three different conditions (see Table 2), by the following procedures:
       1. Room Temperature and Dry: compounds were left at the room temperature (20° C.) under inert dry gas;   2. 30° C. and 65% Humidity: compounds sealed with double bags were put into a stability chamber. Temperature was set at 30° C. while the humidity was controlled at 65%.   3. 37° C. pH=7.4 solution: compounds were dissolved in PBS solution and then the entire solution was submerged under a 37° C. water bath.       
 
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Stability study of designed chiral specific boron derivatives. 
               
             
          
           
               
                   
                 Room Temp 
                 30° C./65% 
                 37° C. 
               
               
                 Compound 
                 Dry 
                 Humidity 
                 H 2 O/pH 7.4 
               
               
                   
               
               
                 HL01-0 
                 − 
                   
                   
               
               
                 HL01-11 
                 + 
                 + 
                 + 
               
               
                 HL01-15 
                 + 
                 + 
                 + 
               
               
                 HL01-17 
                 + 
                 − 
                 Decompose Instant 
               
               
                   
               
               
                 Note: 
               
               
                 “+” meaning stable, “−” meaning quickly degradable, as determined by RP-HPLC. 
               
             
          
         
       
     
       Cell Viability Assay 
     1. Cell Line 
       [0245]    The multiple myeloma cell line MM1.S was obtained from the ATCC. Cells were cultured in standard RPMI-1640 media (Hyclone) supplemented with 10% heat-inactivated fetal bovine serum (Gibco), 1% penicillin/streptomycin (Gibco) and grown in a humidified incubator with 5% CO 2  at 37° C. 
         [0246]    Eight thousand MM1.S cells per well were seeded in tissue culture-treated 96-well plate (Nunc) and incubated overnight. 
       2. Compound Treatment 
       [0247]    Eighteen hours after seeding, MMLS cells were treated with a series of concentrations of five different compounds (Bortezomib, HL01-01, HL01-11, HL01-15, HL01-17) or DMSO vehicle control for 72 hrs in a humidified incubator with 5% CO 2 . at 37° C. The concentrations of five different compounds were 0.3, 1, 3.16, 10, 31.6, 100, 316, and 1000 nM. Each well had the same DMSO concentration of 0.05%. 
       3. Cell Viability Assay (MTS Assay) 
       [0248]    The effects of compounds on cell viability were assessed using CellTiter 96®A Queous One solution Reagent (Promega; G3580). 
         [0249]    After being treated with various compounds for 72 hrs, cells in the 96-well plate were centrifuged 1000 rpm for 3 minutes, and 180 ul supernatant were removed from each well. Cells were incubated with 20 ul CellTiter 96®A Queous One solution Reagent and put into incubator with 5% CO 2 . at 37° C. for an additional 4 hrs. The absorbance was measured at 490 nm with Automatic Microplate reader (Infinite M1000 pro, Tecan). There was a liner relationship (r 2 =0.99) between absorbance and cell number in each plate format. Four sets of experiments for each drug combinations were carried out. Cell viability (Percentage of Cell Survival) was calculated by the following formula: cell viability (%)=(average absorbance of treated group-average absorbance of blank)/(average absorbance of untreated group−average absorbance of blank)×100%. IC50 values were calculated using Prism software. 
       Results 
       [0250]    The cytotoxic effects of compounds including Bortezomib, HL01-11, and HL01-15 on MM1.S cell were assessed using the MTS assay. It was found that all compounds could dose-dependently decrease the cell viability in MM1.S cell. As represented by the cell line assay shown in  FIG. 1 . Bortezomib and HL01-11 exhibited strong cytotoxic effects on MM1.S cells and both compounds had similar IC 50  values nearly 2 nM. The effect of HL01-15 was weaker than the other compounds. The IC 50  value of HL01-15 was 6.85 nM, as set forth in Table 3: 
         [0000]    
       
         
               
               
               
             
           
               
                   
                 TABLE 3 
               
               
                   
                   
               
               
                   
                 Compound 
                 IC 50  (nM) 
               
               
                   
                   
               
             
             
               
                   
                 Bortezomib 
                 1.76 
               
               
                   
                 HL01-01 
                 1.96 
               
               
                   
                 HL01-11 
                 1.62 
               
               
                   
                 HL01-15 
                 6.85 
               
               
                   
                 HL01-17 (Ixazomib) 
                 9.45 
               
               
                   
                   
               
             
          
         
       
     
         [0251]    Five compounds exhibited cytotoxicity in MM1.S cells. MM1.S cells were treated with various concentrations of Bortezomib, HL01-11, and HL01-15 for 72 h. Cell viability was assessed using the MTS assay. Mean±SEM (n=4). 
         [0252]    Although the disclosure has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.