Abstract:
Laboratory Automated System and method for specimen processing, comprising several Clinical and Biological Analytical Modules is provided. The Module consists of coupling centrifuge, analyzers and robot. System produces rapid phase separation, cap removing and testing in one sequential, unbroken process. Several multi-item carriers for tubes and microplates loading provided.

Description:
[0001]     This application claims the benefit of provisional applications: 
    app. Ser. No. 60/511,852 Filing date: Oct. 14, 2003 Applicant: Michael Yavilevich     app. Ser. No. 60/537,093 Filing date: Jan. 15, 2004 Applicant: Michael Yavilevich   
 
     
    
     BACKGROUND OF THE INVENTION  
       [0004]     There have been developed various Laboratory Automated Systems and Automated Centrifuging Systems. Unfortunately the constructions of the Total Laboratory Automated Systems (TLA) and Automated Centrifugation assemblies are very complicated and not suitable for implementation in small and medium clinical laboratories. TLA Technology requires arranging tubes in a line on a transport track before testing. An example of the conveyer system manufacturing by Lab-InterLink, Inc. shows in U.S. Pat. No. 5,614,415. This system uses individual carrier for every specimen tube, movable on the conveyer.  
         [0005]     Since new powerful Analyzers were appearing in Laboratory, tube sorting, sample balancing and separation, robotics load-unload and recapping were arranged around this machines. Some attempts were made to bring testing process nearer physician office. The and for small and medium labs is toward modular automation of analytical processes. An example of module system is described in U.S. Pat. Nos. 6,060,022 and 6,776,961 assigned to Beckman Coulter, Inc. This system uses a number of robots and different tube carriers in centrifuge and analyzer. These systems use many loading-unloading and aliquoting steps and complicated.  
         [0006]     The other example of module system is described in U.S. Pat. No. 6,323,035 assigned to Glaxo Wellcome, Inc. and U.S. Pat. No. 6,691,748 assigned to Precision System Science Co. These assemblies consisting devices and methods for manipulating and handling multi-well plates, but do not provides the step of tube handling and specimen sampling from tubes to microplates.  
         [0007]     Numerous instruments and devices have been developed to increase the efficiency of testing procedures by reducing turnaround time. Original sample preparation systems include many loading-unloading steps. The key goal for automation in diagnostics is to minimize all steps in the lab processes like sorting tubes, recapping, centrifugation, loading tubes in analyzers racks, microplate sampling, testing and storage.  
       BRIEF SUMMARY OF THE INVENTION  
       [0008]     The present invention refers to structure of Laboratory Automated System and to modular automation of pre-analytical and analytical processes of Clinical and Bio Lab Testing Systems. More particularly the present invention relates to compact Analytical Station for loading-unloading tubes, removal-replacement a caps, rapid centrifugation, sampling microplates and testing.  
         [0009]     It is an object of the present invention to provide Universal Laboratory Automated System (ULAS) in general and Fast Automated Analytical Stations (FAAS) in particular. ULAS consist of a grade structure and comprise a number of local Clinical and Biological Automated Analytical Stations.  
         [0010]     According to aspect of the present invention said Clinical Automated Analytical Station contains several Clinical Analytical Modules. Each module may contain coupling centrifuge, robot and at least one analyzer. Centrifuge and analyzer may comprise common parts and devices like refrigerator, motors. Robot arranged near analyzer sampling port and centrifuge loading-unloading port  
         [0011]     According to yet another aspect of the present invention said Biological Automated Analytical Station contains several Biological Analytical Modules. Said module contains coupling sorting deck, robot, centrifuge, dispensary, analyzer and storage units. Centrifuge, analyzer and robot may comprise common parts and devices like refrigerator, motors. Dispensing unit locates near centrifuge loading-unloading port.  
         [0012]     According to another aspect of the present invention there is provided batch methods for loading and unloading tubes, rapid centrifugation, cap removing and sampling for analysis. Tubes number and arrangement in a batch conform to number and arrangement tubes in a centrifuge holding means and suitable for connection to analyzer and robotic assembly.  
         [0013]     According to yet another aspect of the present invention there is provided batch loading-unloading method using universal multi-item transporting means. All transporting carriers contain the same protrusions—wings and/or apertures—slots, permitting arranging in the same Robot simple plate handling gripper. This embodiment allows employing standard robot equipped with plate handling, fork shape grippers.  
         [0014]     All multi-item members effectively connecting with a centrifuge, dispensary, analytical instrument and robot and including: 
        a) Multi-item carrier (MIC) intends for tube loading and unloading inside centrifuge, handler and analyzer.     b) Universal adapter intends for tube loading and unloading inside centrifuge, handler and analyzer.     c) Multi-item plate (MIP) intends for tube loading inside centrifuge and for cap moving away after centrifugation. Said plate provides with compartments for caps placing.     d) Multi-item cap covering (MCC) intends for tube loading inside centrifuge and for cap moving away after centrifugation. Said cap covering provides with springy compartments for engagement with the cylindrical walls of the caps so as frictionally resist movement of the caps within the cap covering, but easy put on the caps.     e) Multi-Cap (MC) intends for tubes recapping and removing from centrifuge to refrigerator storage. Said multi-cap includes springy compartments for engagement with the cylindrical walls of the tubes so as frictionally resist movement of the tube within the multi-cap, but easy put and removed from the tubes.     f) Multi well plate—microplate for biological test.     g) Microplate adapter for loading microplates inside centrifuge.        
 
         [0022]     According to yet another aspect of the present invention there is provided a robotic assembly for delivering samples to module in general and to centrifuge and analyzer in particular. All transporting means contain same parts to fit with simply robotic gripper. This embodiment allows employing standard plate handling robot equipped with fork shape gripper. Said robot intends for placing tubes inside MIC or universal adapter and delivering said means with tubes to centrifuge. Robot moves said means with tubes after specimen separation and cap removing to analyzer. Robot moves away MIP or MCC with caps from centrifuge. Robot transfers tubes closed by multi-caps to storage, after specimen testing. Robot takes multi-cap by wings or slots, put it on the tubes, connect multi-cap with tubes and transfer all batch to refrigerator or storage area.  
         [0023]     According to yet another aspect of the present invention there is provided Fast Spin Centrifuge. Said centrifuge use variably inclination method for rapid separation. Centrifuge casing and drum providing with at least one aperture in upper part of side walls. Apertures use for tube loading-unloading and for direct centrifuge sampling. Electro-mechanical hatches or sash doors close said apertures during rotor spin.  
         [0024]     According to yet another aspect of the present invention there is provided batch cap removing method affected in a said fast centrifuge. The cap removing means is operas by virtue of the centrifugal force developed during the centrifugation run. Said method, realize by using several multi-item means: 
        a) Insert arranged inside universal adapter before tube loading;     b) Multi-item plate (MIP) or multi-item cap covering (MCC) intends for cap moving away after centrifugation.        
 
         [0027]     According to yet another aspect of the present invention analyzer provided with specimen carousel for multi-item carriers or universal adapter placing. Said carousel comprises a number of identical receptacles for receiving multi-item carriers. Inner surface of the carouse fit an outside surface of the MIC and universal adapter to allow inserting said means into the Analyzer.  
         [0028]     According to yet another aspect of the present invention there is provided stationary carriage or movable bidirectional carriage-shuttle. Carriage intends to MIC or universal adapter placing. Inner surface of the carriage fit an outside surface of the MIC and universal adapter to allow inserting said means into or near the analyzer. Movable bidirectional shuttle uses in conjunction with standard sample probe.  
         [0029]     According to yet another aspect of the present invention there is provided multi-coordinate specimen probe or swing out specimen probe. Multi-coordinate probe uses in conjunction with stationary carriage. Swinging probe uses in conjunction with analyzer indexing specimen carousel or indexing centrifuge rotor.  
         [0030]     According to yet another aspect of the present invention there is provided MIC handier, displacing between standard centrifuge and analyzer. Said handler comprise multi-coordinate specimen probe or swing out probe. Said handler may comprise carriage—shuttle or conveyer for MIC placing.  
         [0031]     According to yet another aspect of the present invention there is provided direct—centrifuge sampling method, effected by using indexing centrifuge rotor and turn out indexing sample probe.  
         [0032]     According to direct-centrifuge sampling method of the present invention, centrifuge provided with indexing centrifuge rotor and turn out indexing sample probe.  
         [0033]     According to yet another aspect of the present invention there is provided dispensing unit equipped with a robot. Dispensing unit located near Centrifuge loading area and near Biological Analyzer. Dispensing unit intends for microplates sampling and adding reagent before testing.  
         [0034]     According to yet another aspect of the present invention there is provided machine method for specimen identification, detection, measurement and high speed calculation. Sorting Deck provided with specimen measuring system and software integrated with Laboratory Information System.  
         [0035]     This invention includes a methods and devices for rapid phase separation and cap removing in liquids. These methods now named Fast Spin were described in U.S. Pat. No. 6,234,948.  
         [0036]     Universal Laboratory Automated System (ULAS) consists of grade structures and comprises several parts: 
        General Level:—several High Level Laboratory Systems,     High Level:—Main Laboratory,     Middle Level:—number of Clinical and Biologic Analytical Stations,     Ground Level:—Hospitals, blood taking stations and Physicians Offices.        
 
         [0041]     General Information System (GIS) include a Main Information System (MIS) and a number of Local Information Systems (LIS). Every LIS cooperate local FAAS with its users. Clinical Automated Analytical Station may consist of coupling units: 
        sorting deck,     rapid centrifugation assembly equipped with swing-out rotor. Said centrifuge comprise electro-magnetically unit for displacing the common center of gravity of the holding means,     at least one robotic assembly,     at least one analyzer,     common information system, bar code system; and     storage area.        
 
         [0048]     Biological Automated Analytical Station may consist of coupling units: 
        sorting Deck,     centrifugation assembly,     robotic assembly,     analyzer,     dispensing unit,     common information system, bar code system; and     storage area.        
 
         [0056]     Sample preparation in the sorting deck includes the following steps: 
        detecting an inappropriate sample;     dimension the sample volume;     placing tubes inside MIC;     memorize bar codes and tube arrangement in the MIC;     further loading MIC with tubes into centrifuge buckets.        
 
         [0062]     Sorting deck equipped by weight line. Balance takes a weight of every tube and sends it to computer, which calculates common weight of all samples and determinate virtual batch arrangement. Computer calculates common dimensions of all samples and determinate virtual batch arrangement. Robot picks certain tubes from racks or conveyer and places them inside MIC. Identification system memorizes bar codes, tube arrangement and sample volume of all batches. Preliminary sample volume dimension allow compiling batches with equal weight. This provision gives good centrifuge rotor balancing.  
         [0063]     A method for routing a specimen through Clinical Automated Analytical Station, by using direct centrifuge sampling method of the present invention comprises main steps: 
        Physicians give orders to patients and to LIS.     Taking blood and bar code placing on a tube.     Sending tubes to local FAAS.     Receiving tubes in the FAAS sorting deck.     Sample volume dimension and making batch size calculation;     Memorizing bar codes, tube arrangement and sample volume of all batch.     Placing tubes in an appropriate multi-item carrier.     Placing the multi-item carriers with tubes inside centrifuge bucket.     Spinning the tubes with samples while they are inclined for more rapid phase separation.     Lowering the tubes adapter inside the bucket during spinning, for tubes pivoting into horizontal position.     Spinning the tubes while their longitudinal axes are aligned with the direction of the centrifugation force to allow reliable gel seal.     Displacing the tubes inside the holding means during spinning, for caps removing.     Stopping the centrifuge and opening the centrifuge hatches.     Unloading the cap removing means with caps from centrifuge.     Tube identification before specimen testing.     Sucking specimen from tubes loaded inside centrifuge.     Dropping specimen on analyzer processing ring.     Testing specimens in analyzer.     Placing multi-item cap on tubes.     Tubes removing from centrifuge.     Placing tubes to refrigerator storage.     Sending test result to physician office.        
 
         [0086]     A method for routing a specimen through Biological Automated Analytical Station, by using direct Centrifuge sampling method of the present invention comprises main steps: 
        Physicians give orders to patients and to LIS.     Taking blood and bar code placing on a tube.     Sending tubes to local FAAS.     Receiving tubes in the FAAS sorting deck.     Sample volume dimension and making batch size calculation;     Memorizing bar codes, tube arrangement and sample volume of all batch.     Placing tubes in an appropriate multi-item carrier.     Placing the multi-item carrier s with tubes inside centrifuge bucket.     Spinning the tubes with samples while they are inclined for more rapid phase separation.     Lowering the tubes adapter inside the bucket during spinning, for tubes pivoting into horizontal position.     Spinning the tubes while their longitudinal axes are aligned with the direction of the centrifugation force to allow reliable gel seal.     Displacing the tubes inside the holding means during spinning, for caps removing.     Stopping the centrifuge and opening the centrifuge hatches.     Unloading the cap removing means with caps from centrifuge.     Tube identification before specimen sampling to microplates.     Placing empty microplates on movable bidirectional carriage arranged near centrifuge, for microplates sampling and reagent adding.     Sampling specimens from the tubes loaded within centrifuge to microplate wells by using swinging multi-coordinate sampling probe.     Adding reagents to microplates in dispensing unit.     Placing said microplates inside plate hotel.     Placing said microplates in Analyzer sampling inlet.     Conducting the test on the first set of specimens.     Removing multi-item carriers from centrifuge and microplates from analyzer by using robotic assembly.     Sending test result to physician office.        
 
         [0110]     The clinical module may comprise compact analyzer formed integrally with Fast Spin centrifuge and a robot. The interior of the module may consist of common analyzer and centrifuge parts. The module provided with centrifuge loading port. Centrifuge loading port may arrange within the interior of the analyzer.  
         [0111]     According to the present invention robot can be individual for each module or common for a number modules in the station. Standard six single degree of freedom joints robot provided with a simple plate handling gripper may placed near the module.  
         [0112]     Robotic manipulator placed on a top level of the module. The manipulator may comprise a frame connected with a module, at least pair supporting rails and a bar movable along the supporting rails. Robotic arm connected with the bar. Plate handling gripper has a fork shape and may embrace MIC wings from 3 sides.  
         [0113]     The robot comprises revolving rod, placed in a centre of turntable. Robotic arm connected with the rod. Said arm provided with simple plate handling gripper movable along the arm. Said gripper has a fork shape and may embrace microplate wings. Using the wings and/or slots simplify the gripper design. This embodiment does not require a big tolerance between the wings and gripper.  
         [0114]     The biological module may comprise dispensing apparatus, robot and turntable arranged between centrifuge and analyzer. Turntable intends for placing MIC and microplates and adjusting this means near centrifuge sampling port.  
         [0115]     The rapid centrifuge comprises: 
        a rotor, including a yoke, with a holding means for carrying at least one tube, said tube containing a blood sample and a gel separator, said holding means being pivotable with respect to the rotor;     the tubes holding means equipped with: 
            a) centrifuge bucket and tubes adapter;     b) means for tubes loading and unloading,    
            a means for rotation the rotor about a rotor axis to produce a centrifugal force having its vector radiating from the rotor axis, said centrifugal force is capable: 
            a) to induce phase separation when the tube is pivoted in the first position in which the tube walls are inclined with respect to the vector of the centrifugal force;     b) to allow complete gel seal when the tube is pivoted in the second position in which the tube walls are aligned with the vector of the centrifugal force;     c) to remove caps from the tubes;    
            a displacing means to vary the location of the gravity center of the holding means together with the tube carried thereby during centrifugation;     a stopping means for maintaining a degree of inclination of the tube when it is pivoted in the said first position;     electro magnetically unit for operating the displacing means and tube removing means.        
 
         [0127]     The centrifugation assembly may comprise a swing-out rotor centrifuge, while said rotor carries a yoke for mounting holding means (buckets) thereon. Said buckets comprise adapters for inserting the tube there into. The buckets are mounted on the yoke with possibility for swinging with respect to the yoke. The buckets may comprise the cap-removing insert.  
         [0128]     The centrifugation assembly instead MIC may comprise a universal adapter configured to receive the tubes and to be inserted in the robot gripper and to analyzer loading means. Said adapter contains on an upper surface the cap-removing insert or plate. The said adapter provide with wings or slots and permitting to arrange the adapter on a robot gripper and analyzer carriage.  
         [0129]     In accordance with the method of the rapid separation in a first stage tubes spin in inclined position to the vector of centrifugal force. This embodiment allows more rapid phase separation between serum, clot and gel. Tube inclination is significant factor in a liquids rapid separation. Centrifuge use variably inclination method for rapid separation. Inclination angle vary from 90 to 0 during same spin. Inclination degree depends from the kind of separated substance and design of inclination device. The method of the present invention recommended in a case of a whole blood to use a big (70-90) degree of tube initial inclination. In opposite in a case of a clot blood said method recommended small (0-30) degree of the tube inclination to the vector of centrifugal force.  
         [0130]     The degree of inclination of the buckets is maintained by a stopping means comprises a cam mounted on the rotor. Said cam provided with at least one contact surface capable to lean against the buckets when buckets is pivoted in said first position so as to maintain the degree of inclination of the tubes. Said cam movable by centrifugal force or by using electro magnetically device.  
         [0131]     After completing the first stage of the separation the common center of gravity of the buckets and of the tubes placed therein is displaced in the second position. During the second stage the centrifugal force urges the buckets with tubes to pivot into horizontal position in which they could have been aligned with the vector of the centrifugation force and thus the complete gel seal can take place. The stopping means does not prevent this pivoting movement. In the end of the second stage the centrifuge is stopped and the buckets and tubes return back into the initial position.  
         [0132]     According to the present invention lowering the common center of the gravity of the buckets realize by displacing the adapter and tubes inside centrifuge bucket. The displacing means may be electro magnetically controlled. The movement of the adapter within the bucket can be affected in a controllable manner by using electromechanical sensor, timer and solenoids mounted on a centrifuge buckets. The sensor sends a signal to a self—aligning control system of the displacing means after beginning centrifugation and fixing means removing solenoid pins from the protruding position to relieve the adapter. The bucket provided with a springy means urging the adapter to move from a lowermost extremity of the bucket to an uppermost extremity.  
         [0133]     The cap removing means is operated by virtue of the centrifugal force developed during the centrifugation run. Caps removing means may comprise: 
        Insert removable connected to an upper part of the centrifuge bucket, said insert being provided with a perforated partition transverse to the length of the tube, the diameter of at least one perforation of the partition fitting the outside diameter of the tube so as to allow insertion of the tube within the holding means through the perforation, and the cap having an outside diameter larger than the perforation diameter;     Adapter for supporting the tube after being inserted in to the bucket, said adapter movable by the centrifugal force along the longitudinal axis of the bucket from an uppermost position to a lowermost position,     A fixing means for preventing movement of the adapter by the centrifugal force from the uppermost position toward the lowermost position when the holding means is pivoted in the first position. The fixing means may be electro magnetically controlled,     A springy means for returning the adapter from the lowermost position into the uppermost position.        
 
         [0138]     The tubes are movable within the adapter by the centrifugal force toward the lowermost position. The caps lean against the partition of the MIC or insert, so as to remove the caps from the tubes. In the lower part of the tubes adapter there is provided a common springy pad capable to protect tubes. After separation and cap removing Robot move away caps from centrifuge.  
         [0139]     The aspect of the present invention is to use standard testing technology and existent compact analyzer. Compact analyzer includes standard parts like a reaction tank with reaction containers, reagent tanks with reagent containers, reagent pipettes and washing device. The example of a standard, compact analyzer shown in U.S. Pat. Nos. 6,042,786 and 6,500,388 assigned to Hitachi, Ltd. This analyzer may equip with a new multi-coordinate specimen probe and/or multi-coordinate carriage, which intends to MIC placing.  
         [0140]     Robot load MIC with tubes inside the fast centrifuge buckets. Inner surface of the buckets fit an outside surface of the MIC, to allow inserting said MIC into the Centrifuge. After centrifuge spin robot move away cap removing plate or cap covering with caps from centrifuge.  
         [0141]     This embodiment allows sucking a sample from tubes placed inside centrifuge and transferring specimen to Analyzer processing ring or to microplate&#39;s wells. After testing, robot removes MIC with tubes from centrifuge. After direct centrifuge testing disposable multi-cap is available for tube recapping and removing from centrifuge to storage. Disposable MIC, cap removing plate and cap covering is available to the present invention in a big Laboratory Automated Systems. Durable insert placed inside centrifuge bucket to support disposable MIC during centrifugation run.  
         [0142]     Direct-centrifuge sampling method use indexing centrifuge rotor and turn away indexing probe. Said probe swing away from analyzer and moves above centrifuge sampling port. Centrifuge rotor indexed to plurality of rest positions to allow placing bucket with tubes near sample probe. Rotor turns in determinate angle and logical adjusts every tube under probe. Said probe suck sample from the tubes placed inside centrifuge. The example of analyzer equipped with turn away probe is standard ADVA 1650 assigned to Bayer Corporation.  
         [0143]     Bar code reader or other Identification System registers batch number and LIS determinate specimen&#39;s volume and arrangement in a batch and send this information to module processor. Processor manages the analyzer probe movement regarding previously determine algorithms. Specimen probe equipped with a sample pipette, which let down in a certain depth and take a sample from a certain tube. In a next step a sample and a reagent are reacted with each other in a reaction container so as to analyze thus obtained reacted liquid.  
         [0144]     LIS moves specimens throughout the FAAS for processing, completion of analytical results and to archive or disposal when processing is completed. The process control system includes a sophisticated scheduling module that follows the progress of the specimen throughout its automated pre-analytical processing, analytical, and post-analytical stages. LIS connects Hospitals and Physicians Offices with FAAS and rapidly supplies test results to physicians. The LIS use batch identification method to find the tube with a specimen that has previously testing. Operator then places said tube back to the module from storage if necessary.  
         [0145]     The present invention in its various embodiments referring to the different groups above has only been summarized briefly. For better understanding of the present invention as well of its benefits and advantages reference will now be made to the following description of its embodiments taken in combination with the accompanying drawings.  
     
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       [0146]      FIG. 1   a  shows schematically the structure of Universal Laboratory Automated System.  
         [0147]      FIG. 1   b  shows schematically the structure of Fast Automated Analytical Station.  
         [0148]      FIGS. 2-11  show different embodiments of presented multi-item members.  
         [0149]      FIG. 2  shows the MIC loaded inside the centrifuge bucket.  
         [0150]      FIG. 3  shows the disposable MIC loaded inside the centrifuge bucket.  
         [0151]      FIG. 4   a  shows 3 D view of the MIC with tubes after cap removing.  
         [0152]      FIG. 4   b  shows 3 D view of the MIC with tubes after cap removing.  
         [0153]      FIG. 5  shows universal adapter loaded inside the centrifuge bucket.  
         [0154]      FIG. 6  shows 3 D view of the universal adapter with tubes after cap removing.  
         [0155]      FIG. 7  shows the Multi-Item Plate loaded inside the centrifuge bucket.  
         [0156]      FIG. 8  shows the disposable Multi-Item Plate loaded inside the centrifuge bucket.  
         [0157]      FIG. 9  shows the microplate loaded inside the microplate adapter.  
         [0158]      FIG. 10   a  shows 3 D view of Multi-Item Plate with tubes.  
         [0159]      FIG. 10   b  shows 3 D view of Multi-Item Plate with caps.  
         [0160]      FIG. 11   a  shows 3 D view of Multi-Cap with wings.  
         [0161]      FIG. 11   b  shows 3 D view of Multi-Cap with slots.  
         [0162]      FIGS. 12-22  show different embodiments of presented Analytical Module.  
         [0163]      FIG. 12  shows the Maxi Clinical Analytical Module.  
         [0164]      FIG. 13  shows the Clinical Analytical Module comprising two Analyzers.  
         [0165]      FIG. 14  shows the Clinical Analytical Module comprising Conveyer.  
         [0166]      FIG. 15  shows the Clinical Analytical Module comprising Tube Handler.  
         [0167]      FIG. 16  shows the Biological Analytical Module using microplates sampling.  
         [0168]      FIG. 17  shows 3 D view of presented Analytical Module and Robot.  
         [0169]      FIG. 18  shows 3 D view of Mini Clinical Analytical Module and Robot.  
         [0170]      FIG. 19  shows 3 D view of Biological Pre-Analytical Module and Robot.  
         [0171]      FIG. 20  shows section view of combine Clinical Analytical Module.  
         [0172]      FIG. 21  shows 3D view of combine Clinical Analytical Module.  
         [0173]      FIG. 22  shows 3D view of combine Biological Analytical Module.  
     
    
     DETAILED DESCRIPTION OF THE INVENTION  
       [0174]     With reference to  FIG. 1   a  and  FIG. 1   b  the structure of Universal Laboratory Automated System will be briefly explained.  
         [0175]     Main Laboratory (ML)  2  and General Information System (GIS)  4  are the High Level of the System.  
         [0176]     Medium Level includes several Branches: A, B, C, D divided geographically in a country.  
         [0177]     Every Branch include a main part: Local Information System (LIS)  6  and Fast Automated Analytical Stations (FAAS)  8  and a periphery: hospitals  10 , physician offices  12 , independent labs  14  and local blood taking stations  16 . Local Information System LIS  6  connected with GIS  4 .  
         [0178]     Physicians  12  give orders and LIS  6  send patient to one of the local blood tacking stations  16 . Some independent labs  14 , stations  16  and hospitals  10  make centrifugation before sending tubes to FAS, to provide blood separation in a good time. In this cases tubes was previously sorted and loaded inside appropriated MIC.  
         [0179]     Local Information System (LIS)  6  connect local FAAS  8 , physician offices  12 , independent labs  14  and blood taking stations  16  with ML  2  and GIS  4 .  
         [0180]     With reference to  FIG. 1   b  the structure of Fast Automated Analytical Stations (FAAS)  8 , will be briefly explained.  
         [0181]     Automated Analytical Station  8  includes sorting deck  20 ; robotics units  28  and  34 , centrifuge  24 , dispensing unit  36 , analyzers  26  and  38 , recapping station  30 , and storage area with refrigerator  32 .  
         [0182]     Centrifuge  24 , analyzer  26  and robot  28  unite in clinical analytical module  18 . Centrifuge  24 , robot  34 , dispensing unit  36  and analyzer  38  unite in biological analytical module  22 . Bar code reading system, computer and electromechanical units do not show in this scheme. Each FAAS contains multi-item carriers for tubes placing, instead of standard tube racks.  
         [0183]     Now with reference to FIGS.  2  it will be explained how the adapter  52  lowering the common center of the gravity of the buckets  50 . Also shown how caps  42  removing from the tubes  40  during centrifugation.  
         [0184]     Tubes  40  sealed by caps  42  loaded inside multi-item carrier (MIC)  44  before centrifugation and cap removing. MIC  44  intends for transporting and placing with tubes  40  inside the centrifuge and analytical instrument. MIC  44  built in conjunction with wings  46  and deflectable clamps  48 . Clamps  48  embrace tubes  40  and hold them during loading-unloading operations. Said horizontal wings  46 , intends to arrange the carrier  44  on a robot gripper.  
         [0185]     The centrifuge bucket  50  placed on a centrifuge rotor yoke (shown in  FIG. 12 ). Adapter  52  placed inside bucket  50 . On the outer side of the bucket  50  there is mounted a retaining means, for example a solenoid  54 , capable to retain the adapter  52  proximate to the upper extremity of the bucket  50 . In the lower part of the tubes adapter  52  there is provided a springy pad capable to protect tubes.  
         [0186]     During the centrifugation run the adapter  52  is urged by the centrifugal force to move down and to take its lowermost position. The adapter  52  is supported by solenoid pins  56 . After the separation is over the solenoids  54  remove the pins  56  from the protruding position to relieve the adapter  52 . Now the centrifugal force urges the adapter  52  and the tubes  40  to move further and to reach the lowermost position. The common center of gravity displaced in the second position by the adapter  52  movements. The bucket  50  and tubes  40  takes the horizontal position. The tubes remain in this position until the gel seal is formed and separation is completed.  
         [0187]     It can be appreciated that during the final stages caps  42  become removed from the tubes  40  due to the leaning against the partition of the MIC  44  by virtue of the centrifugal force developed during the centrifugation run.  
         [0188]     Now the assembly is stopped and springs  58  return the adapter  52  in the uppermost position. The solenoids  54  urge the fixing pins  56  to protrude and to lock the uppermost position of the adapter  52 . The multi-tube carrier  44  is ready for removing from the bucket  50 .  
         [0189]     Cap covering  60  have a springy compartments, which keep caps  42  during spin and unloading operation. The said cap covering  60  may be formed with a same outside horizontal wings  46 , permitting to arrange the cap covering  60  on a robot gripper.  
         [0190]     The said MIC  44  formed with extending up deflectable, springy catches  64 . Catches  64  have thickened part that connects with an opening on a sidewall of cap covering  60 . This embodiment lock caps  42  on a centrifuge holding means during spin vibration since the caps are reliably secured in covering compartments.  
         [0191]     The robot (shown in  FIG. 12 ) use same gripper to remove away cap covering  60  with caps  42  from carrier  44 . Gripper move horizontally and embrace covering  60  wings  46 . The gripper inner surface pres catches  64  thickened parts. After catches  64  releases covering  60 , gripper move vertically and remove away covering with caps  42 .  
         [0192]     Robot places the carrier  44  with tubes on the analyzer or a waiting bench, after removing from the bucket  50 .  
         [0193]     In  FIG. 3  show the disposable multi-item carrier  74  connected with centrifuge bucket  50 . Disposable cap removing plate  62  and tubes  40  sealed by caps  42  loaded inside multi-item carrier  74  before centrifugation and cap removing. MIC  74  intends for transporting by robot and placing with tubes  40  inside the centrifugation assembly and analytical instrument. MIC  74  built in conjunction with wings  46  and deflectable clamps  48 . Clamps  48  embrace tubes  40  and hold them during loading-unloading operations. The said outside horizontal wings  46 , permitting to arrange the carrier  74  on a robot gripper. Bucket  50  contains on an upper surface the cap-removing insert  70 . Said insert  70  support MIC  74  during spin and cap removing. Caps  42  removing from the tubes  40  during centrifugation by the same means mentioned in previous embodiment.  
         [0194]     In  FIG. 4  show 3 D view of the multi-tube carrier  44  with tubes  40  after cap removing. In  FIG. 4   a  cap covering  60  moved away to show caps  42  inside their compartments. In  FIG. 4   b  cap removing plate  72  with caps  42  moved away. Catches  64  connect with an opening on a sidewall of cap removing plate  72 . This embodiment lock plate  72  and caps  42  on a centrifuge holding means during spin vibration since the caps are reliably secured in plate  72  compartments.  
         [0195]     In  FIG. 5  show additional embodiment of the present invention, which employs universal adapter  66  provided within the bucket  50 . In this embodiment the adapter  66  comprises wings  46 , which are similar to that of the  FIG. 2 . Said wings  46  are fixedly secured in the upper part of the adapter  66 . Said adapter  66  contains on an upper surface the cap-removing insert  70 . During the centrifugation run the adapter  66  is urged by the centrifugal force to move down and to take its lowermost position. The adapter  66  is supported by solenoid pins  56  and springs  58  capable to return the adapter along the bucket from its lowermost position to the initial position.  
         [0196]     After the separation is over the solenoids  54  remove the pins  56  from the protruding position to relieve the adapter  66 . Now the centrifugal force urges the adapter  66  and the tubes  40  to move and to reach the lowermost position. The common center of gravity displaced in the second position by the adapter  66  movements. The bucket  50  and tubes  40  takes the horizontal position. The tubes remain in this position until the gel seal is formed and separation is completed.  
         [0197]     It can be appreciated that during the final stages caps  42  become removed from the tubes  40  due to the leaning against the partition of a cap-removing insert  70  by virtue of the centrifugal force developed during the centrifugation run.  
         [0198]     Now the assembly is stopped and springs  58  return the universal adapter  66  in the uppermost position ready for removing from the bucket  50 . The solenoids  54  urge the fixing pins  56  to protrude and to lock the uppermost fixing position of the adapter  66 .  
         [0199]     The said adapter  66  may be formed with extending up deflectable, springy catches  64 . Catches  64  have thickened part that connects with an opening on a sidewall of cap covering  60 . This embodiment lock caps  42  on a centrifuge holding means during spin vibration since the caps are reliably secured in covering compartments.  
         [0200]     The robot (shown in  FIG. 12 ) use same gripper to remove away cap covering  60  with caps  42  from universal adapter  66 . Gripper move horizontally and embrace covering  60  wings  46 . The gripper inner surface pres catches  64  thickened parts. After catches  64  releases covering  60 , gripper move vertically and remove away covering with caps  42 .  
         [0201]     Before removing adapter  66  from centrifuge, the solenoids  54  remove the pins  56  from the protruding position to relieve the adapter  66 . Robot places the universal adapter  66  with tubes on the Analyzer carriage or a waiting bench, after removing from the bucket  50 .  
         [0202]     In  FIG. 6  show 3 D view of the universal adapter  66  with tubes  40  after cap removing. In this embodiment uses multi-item plate  72  for caps  42  removing and moving away. Plate  72  has springy compartments, which keep caps  42  during spin and unloading operation. This embodiment allows using plate  72  to remove away caps  42  from centrifuge after spin is over. The said plate  72  formed with outside horizontal wings  46 , permitting to arrange the plate  72  on a robot gripper. Said plate  72  with caps  42  inside their compartments moved away from adapter  66  by using robot gripper  10 .  
         [0203]     It should be understood that in the embodiments shown in  FIGS. 2-6  there can be implemented either rapid separation or removal of the caps or both. It can be realized that this embodiment does not require taking the tubes out of the multi-tube carrier  44  or universal adapter  66  for cap removing and testing.  
         [0204]     In  FIG. 7  show multi-item plate  72  with tubes  40  sealed by caps  42  loaded inside centrifuge bucket  50  before centrifugation and cap removing.  
         [0205]     In  FIG. 8  show disposable multi-item plate  62 . In this embodiment rigid insert  70  loads inside bucket  50  to support plate  62 .  
         [0206]     Plates  72  or  62  uses in direct centrifuge sampling method, for tubes  40  loading and cap  42  removing during centrifugation spin. Said plates intends for transporting tubes  40  with caps  42  by robot and placing inside the centrifugation assembly. Plate  72  or  62  embrace caps  42  and hold tubes  40  during loading operations. Said plates  72  and  62  formed with outside horizontal wings  46 , permitting to arrange it on a robot gripper.  
         [0207]     It can be appreciated that during the final stages caps  42  become removed from the tubes  40  due to the leaning against the partition of the multi-item plate  72  or  62  by virtue of the centrifugal force developed during the centrifugation run. Multi-item plates  72  and  62  have springy compartments, which keep caps  42  during spin and loading operation. This embodiment allows using multi-item plates  72  and  62  to remove away caps  42  from centrifuge after spin is over. Robot use simply gripper to remove away plates  72  or  62  with caps  42 . Gripper move horizontally and embrace wings  46 . After this gripper move vertically and remove away plate  72  or  62  with caps  42 .  
         [0208]     It should be understood that in the embodiments shown in  FIGS. 7 and 8  there can be implemented both rapid separation, caps removing and direct centrifuge sampling. It can be realized that this embodiment allow taking the tubes out of the centrifuge adapter  52  after specimen sampling by using multi-caps  68  or  76  shown in  FIGS. 11   a  and  11   b.    
         [0209]     In  FIG. 9  show microplates  82  loaded inside microplate adapter  84 . Adapter  84  intends for microplates  82  placing and loading within the centrifuge bucket  50 . Microplate  82  provided at least a pair protrusions—wings  46  or slots  78  on side walls, permitting to arrange the carrier on a robotic simply plate handling gripper.  
         [0210]     Adapter  84  provided with a hollow body. Inner surface of this body fit an outside surface of the microplate  82  to allow inserting at least one microplate  82  into the adapter  84 . Sidewalls of the adapter  84  provides with at least two openings permitting microplates wings  46  protrude from said walls. Robotic simply plate handling gripper load microplates  82  inside adapter  84 . Adapter  84  provided at least a pair protrusions—wings  46  or slots  78  on side walls, permitting to arrange the adapter on a robotic simply plate handling gripper.  
         [0211]     In  FIG. 10   a  show 3 D view of robot gripper  110  loaded multi-item plate  72  with tubes  40  inside centrifuge.  
         [0212]     In  FIG. 10   b  show 3 D view of robot gripper  110  move away multi-item plate  72  with caps  42  from centrifuge after cap removing.  
         [0213]     In  FIG. 11   a  show 3 D view of robot gripper  110  move away multi-cap  68  with tubes  40  from centrifuge after testing. Robot takes empty multi-cap  68  by wings  46 , connects it with tubes  40  and move away.  
         [0214]     In  FIG. 11   b  show 3 D view of robot gripper  110  move away another embodiment of multi-cap  76  with tubes  40  from centrifuge after cap removing and testing. Multi-Cap  76  formed with outside horizontal slots  78  for gripper  110  arrangements.  
         [0215]     Multi-caps  68  or  76  use to remove tubes  40  from module after sampling and testing.  
         [0216]     In  FIGS. 12-22  the principle of the different embodiments of the analytical module will be briefly explained.  
         [0217]     With reference to  FIG. 12  show clinical module  18  comprises coupling centrifuge  24  and compact analyzer  26  having common working area and adjusted each other. Robot takes multi-tube carriers  44  from sorting deck  20  and place in centrifuge waiting bench  104 . Centrifuge  24  in its inner part contains a rotor  80  dedicated for buckets  50  placing. When centrifuge lid is open robot  28  take carriers  44  with tubes  40  and place inside buckets  50 . This embodiment allows arranging centrifuge  24  near analyzer  26  and do not required rotor  80  indexing. Rotor  80  contains transmitters for determination buckets  50  position. Robot  80  lowers arm  112  inside centrifuge inner area and turns the gripper  110  to the bucket  50  direction. After separation and decaping robot  28  removes away cap coverings  60  with caps  42  from multi-tube carriers  44  and transfer said carriers  44  to analyzer waiting bench  106 .  
         [0218]     Compact analyzer  26  includes standard parts like a reaction tank  92  with reaction containers, reagent tanks  96  with reagent containers, reagent pipettes  98  and washing device (not shown). Analyzer  26  provided with multi-coordinate specimen probe  90  and bidirectional carriage  88 , which intends for multi-tube carrier  44  placing. Carriage  88  configured with the sides similar to that of the multi-tube carrier  44  so as to enable insertion of the carrier within the carriage  88 . Carriage  88  may have revolve and/or prismatic far and wide movement regarding analyzer specimen probe  90 .  
         [0219]     Said module  18  uses direct multi-tube carriers  44  sampling method. Since multi-tube carriers  44  with tubes  40  loaded in carriage  88  a specimen probe  90  takes sample from tubes  40  in a logical manner and transfer it to analyzer processing ring  92 . Bar code reader registers bar code label placed on the carrier  44  and LIS determinate specimen volume and tube arrangement in the said carrier.  
         [0220]     Robotic manipulator  28  placed in a top of the module  18 . The manipulator  28  comprise a frame  118  connected with a module  18 , at least pair supporting rails  116  and a bar  114  movable along the supporting rails  116 . Robotic arm  112  moves lengthways the bar  114 . The robot gripper  110  configured like a fork and has a groove in an inner part to receive wings  46 . Plate handling gripper  110  embraces the wings  46  by its inner surface. The wins lean  46  in a surface of gripper groove.  
         [0221]     With reference to  FIG. 13  shows, clinical automated analytical module  18 , with at least two automatic clinical analyzers are linked together. Module  18  comprises coupling centrifuge  24 , robot  28  and a pair analyzers  26  having specimen carousel  94  for MIC loading. Robotic manipulator  28  placed in a top of the module  18 . Robotic arm  112  comprises base  120  and rod  122  movable inside said base  120 .  
         [0222]     Centrifuge  24  in its inner part contains a rotor  80  for buckets  50  placing. When centrifuge lid is open, robot  28  take carriers  44  with tubes  40  from centrifuge waiting bench  104  and place inside buckets  50 . After separation and decaping robot  28  removes away cap coverings  60  with caps  42  from multi-tube carriers  44  and transfer said carriers  44  to first analyzer  26 . Indexing carousel  94  provided with compartments for loading MIC.  
         [0223]     Since multi-tube carriers  44  with tubes  40  loaded in carousel  94  swinging indexing probe  100  takes specimen from tubes  40  in a logical manner and transfer it to analyzer processing ring  92 . Bar code reader register bar code label placed on the carrier  44  and LIS determinate specimen volume and arrangement in the batch.  
         [0224]     After providing test in a first analyzer  26  robot transfer said MIC to second analyzer.  
         [0225]     With reference to  FIG. 14  the module  18  comprises outer conveyer tracks  124  and  126  formed integrally with centrifuge  24 , at least a pair clinical analyzers  26  and a robot  28 . Compact analyzer  26  includes standard parts like a reaction tank  92  with reaction containers, reagent tanks  96  with reagent containers, reagent pipettes  98  and washing device. Analyzer  26  equips with swinging out indexing probe  100  for direct track sampling from tubes loaded inside MIC  44  on track  126 .  
         [0226]     The conveyer loading track  124  and unloading track  126  arranging near the module  18 . Conveyer track  124  connected module  22  with the sorting deck  20 . Sorting deck  20  equip with robot, which place tubes  40  inside multi-tube carriers  44  and place said carriers with tubes  40  in the loading track  124 .  
         [0227]     Centrifuge  24  in its inner part contains a rotor  80  for buckets  50  placing. When centrifuge lid is open, robot  28  take carriers  44  with tubes  40  from loading track  124  and place inside buckets  50 . After separation and decaping said robot  28  transfer carriers  44  to unloading track  126 . Robot  28  removes away cap coverings  60  or plate  72  with caps  42  from multi-tube carriers  44 .  
         [0228]     Tracks  124  and  126  configured with the compartments similar to that of the multi-tube carrier  44  so as to enable insertion of the carriers inside conveyer. Since multi-tube carriers  44  with tubes  40  loaded in track  126  swinging out indexing specimen probe  100  takes sample from tubes  40  in a logical manner and transfer it to analyzer processing ring  92 . Bar code reader register bar code label placed on the carrier  44  and LIS determinate specimen volume and arrangement in the batch.  
         [0229]     With reference to  FIG. 15  the module  18  comprises handler  102  formed integrally with centrifuge  24 , a pair of clinical analyzers  26  and a robot  28 . Handler  102  may equip with multi-coordinate specimen probe  90  or swing out indexing probe  100 . Compact analyzer  26  includes standard parts like a reaction tank  92  with reaction containers, reagent tanks  96  with reagent containers, reagent pipettes  98  and washing device.  
         [0230]     The handler  102  includes loading conveyer  124  and unloading conveyer  126  arranging within the interior of the handler  102 . Conveyer track  124  connected handler  102  with the sorting deck  20 . Sorting deck  20  equip with robot, which place tubes  40  inside multi-tube carriers  44  and place said carriers with tubes  40  in the loading track  124 .  
         [0231]     Centrifuge  24  in its inner part contains a rotor  80  for buckets  50  placing. When centrifuge lid is open, robot  28  take carriers  44  with tubes  40  from loading conveyer  124  and place inside buckets  50 . After separation and decaping said robot  28  transfer carriers  44  to unloading conveyer  126 . Robot  28  removes away cap coverings  60  or plate  72  with caps  42  from multi-tube carriers  44 . Tracks  124  and  126  configured with the compartments similar to that of the multi-tube carrier  44  so as to enable insertion of the carriers inside conveyers.  
         [0232]     Since multi-tube carriers  44  with tubes  40  loaded on conveyer  126  specimen pipette  90  or  100  takes sample from tubes  40  in a logical manner and transfer it to analyzer processing ring  92 . Bar code reader register bar code label placed on the carrier  44  and LIS determinate specimen volume and arrangement in the batch.  
         [0233]     With reference to  FIG. 16  biological module  22  comprises centrifuge  24 , plate hotel and chiller  150 , biological analyzer  38  and a robot  28 .  
         [0234]     The module  22  comprises outer conveyer tracks  154  and  156  formed integrally with centrifuge  24 . Track  154  intends to MIC  44  loading and unloading. Conveyer track  154  connected module  22  with the sorting deck  20 . Sorting deck  20  equip with robot, which place tubes  40  inside multi-tube carriers  44  and place said carriers with tubes  40  in the loading track  124 . Track  156  intends to microplate  82  loading, sampling and unloading.  
         [0235]     Robotic manipulator  28  placed in a top and connected module  22  with sorting deck  20 , plate hotel  150  and biological analyzer  38 . When centrifuge lid is open, robot  28  take carriers  44  with tubes  40  from track  154  and place inside buckets  50 . After separation robot  28  removes away cap coverings  60  or plate  72  with caps  42  from multi-tube carriers  44 .  
         [0236]     Centrifuge  24  provided with indexing rotor  80  and swing out probe  100  for direct centrifuge sampling. Since robot  28  place microplates  82  on track  156 , swing out probe  100  takes sample from tubes  40  in a logical manner and transfer it into microplates  82  wells. Bar code reader register bar code label placed on the microplates  82  and LIS determinate specimen arrangement in the array. After adding reagent, robot  28  takes microplates from track  156  and place inside plate hotel and chiller  150  or biological analyzer  152 .  
         [0237]     With reference to  FIG. 17  show 3 D view of clinical module  18 . Robotic manipulator  28  placed in a top of the module  18 . The manipulator  28  comprise a frame  118  connected with a module  18 , at least pair supporting rails  116  and a bar  114  movable along the supporting rails  116 . Robotic arm  112  comprises base  120  and rod  122  movable inside said base  120 . The robot gripper  110  configured like a fork and move away cap removing plate  72  with caps  42 . Centrifuge provided with indexing rotor  80  for direct centrifuge sampling. Swing out probe  100  takes sample from tubes  40  in a logical manner and transfer it to analyzer processing ring  92 . Bar code reader register bar code label placed on the carrier  44  and LIS determinate specimen volume and arrangement in the batch.  
         [0238]     After testing, robot  28  takes MIC  44  or universal adapter  66  by wings and move away from module to recapping station arranged near the module. In the recapping station (not shown) robot  28  place multi caps  68  or  76  on the MIC  44  or adapter  66  and remove tubes  40  to the storage refrigerator  32 .  
         [0239]     This module intends to small laboratories and able to work in conjunction with sorting deck  20  and refrigerator storage  32  in a real time regime.  
         [0240]     With reference to  FIG. 18  show 3 D views of mini clinical module  18  assembling with out standing robotic manipulator  160 . Module  18  contains clinical analyzer  26  coupling with centrifuge  24 .  
         [0241]     The interior of the module  18  may contain common refrigerator and motor. The module  18  includes loading-unloading port  86  arranging within the interior of the analyzer  26 . Centrifuge  24  equipped with automated opening and closing lid and contains adapter lifting mechanism. By virtue of this provision the adapter  66  or multi-tube carrier  44  lifting automatically from centrifuge inner area  82  to the loading-unloading port  86 .  
         [0242]     Compact analyzer  26  includes standard parts like a reaction tank  92  with reaction containers, reagent tanks  96  with reagent containers, reagent pipettes  98  and washing device (not shown). This embodiment allows arranging analyzer  26  above centrifuge  24  and decreases the module  18  sizes. Module  18  comprises multi-coordinate specimen probe  90  and centrifuge  24  provided with indexing rotor  80  for direct centrifuge sampling. Said probe  90  suck specimen from the tubes placed inside centrifuge and drop it in the analyzer reaction containers.  
         [0243]     Assembly use robot  160  with one combine revolve and prismatic joints for arm and two prismatic joints for grippers. Robot  160  consists of basis  148 , base  128 , Rode  130 , Arm  146  and two grippers  110 . Robot  160  takes MIC  44  or universal adapter  66  or multi-item plate  72  with tubes  40  and load inside centrifuge  24 .  
         [0244]     When centrifuge lid is open and adapter lifted in the port  86  area, robot  160  take carriers  44  with tubes  40  from sorting deck and place inside adapters. Centrifuge rotor  80  turn on  90  degree and other bucket  50  lift in port  86  area. Robot  28  takes a next MIC  44  and put inside adapter. After loading two or four MIC  44 , centrifuge  24  spins them, around 1 min for separation serum, clot and gel and for caps  42  removing. Now the rotor  80  is stopped and first adapter  66  returns to its upper position in the port  86 . Robot  160  moves away cap-covering  60  or plate  72  with caps  42  for direct centrifuge sampling.  
         [0245]     Multi-coordinate specimen probe  90  takes a sample from tubes  40  placed inside adapter  66  in the port  86 . Specimen probe  90  takes samples from tubes  40  in a logical manner and transfers it to reaction containers in the ring  92 . Analyzer begins processing and testing since first specimen reaches the said reaction container. Bar code reader register bar code label placed on one or two tubes and LIS determinate specimen arrangement in the all batch. At this time rotor  80  turn on 90 or 180 degree and other adapter  66  with next separated tubes  40  lift in the port  86  areas. After sampling all tubes  40  in the MIC  44  robot  160  remove MIC  44  from module  18  to recapping station  30 . Robot takes the new MIC  44  within tubes  40  from sorting deck  20  and place inside empty adapter lifted in a port  86 .  
         [0246]     Said mini module  18  does not require waiting area in a working surface since sorting deck, centrifuge, compact analyzer and robot logically operate tubes arriving to the laboratory. This assembly intends to small laboratories and able to work in conjunction with sorting deck  20  and refrigerator storage  32  in a real time regime  
         [0247]     With reference to  FIG. 19  show 3 D views of pre-analytical module  170  assembling with biological analyzer  38 , plate hotel (not shown), dispersing unit (not shown) and out standing serial robot  174  with six single degree of freedom joints.  
         [0248]     Module  170  contains centrifuge  24 , multi-coordinate specimen probe  90 , washing device  172  and microplate carriage  168 . The centrifuge  24  contains loading-unloading port  86  arranging near of the carriage  168 . Centrifuge  24  equipped with automated opening and closing lid and contains adapter lifting mechanism. By virtue of this provision the adapter  66  or multi-tube carrier  44  lifting automatically from centrifuge inner area to the loading-unloading port  86 . Robot  174  provided with one universal gripper  110 . Robot  174  takes MIC  44  or Universal Adapter  66  or Multi-Item Plate  72  with tubes  40  and load inside centrifuge  24 .  
         [0249]     Centrifuge provided with indexing rotor  80  for direct centrifuge sampling. After separation and cap removing probe  90  suck specimen from the tubes  40  placed inside carrier  44  or universal adapter  66  and drop it in the microplates  82 , places on carriage  168 . Specimen probe  90  takes samples from tubes  40  in a logical manner and transfers it to microplates wells. After sampling robot  174  remove microplate  82  from carriage  168  and put inside analyzer  38  or plate hotel  150 . At this time rotor  80  turn on 90 or 180 degree and other adapter with next separated tubes  40  lift in the port  86  areas. After testing, robot  174  takes MIC  44  and microplates  82  by wings  46  and move away from module  170 .  
         [0250]     This embodiment allows arranging analyzer  38  near centrifuge  24  and decreases the module  170  sizes. Said mini module  170  does not require waiting area in a working surface since sorting deck, centrifuge, compact analyzer and robot logically operate tubes arriving to the laboratory. This assembly intends to small laboratories and able to work in conjunction with sorting deck  20  and refrigerator storage  32  in a real time regime  
         [0251]     With reference to  FIG. 20  and  FIG. 21  shown the clinical analytical module  18  comprises coupling centrifuge  24 , turn table  152 , robot  34  and compact analyzer  26  having common working area and adjusted each other. Said module  18  uses direct centrifuge sampling method. Robot  34  connected module  18  with sorting deck  20 .  
         [0252]     Robotic assembly  34  built in conjunction with turntable  152 . Turntable  152  contains the benches  144  for placing MIC  44  or universal adapter  66  and adjusting near centrifuge  24  loading area. Rotation mechanism  162  rotates turntable  152  about the rotation shaft coaxial with robotic revolving rod  130 . The robotic manipulator  34  comprises base  128 , connected with turntable  152  and revolving rod  130  coaxial with said base  128 . Robotic arm  146  connected with the rod  130 . Robotic arm  146  includes two grippers  108  and  110 .  
         [0253]     Robot  34  load tubes  40  inside MIC  44  or multi-item plates  72  and, after it, load said means with tubes inside centrifuge bucket  50 . Gripper  108  embrace tubes  40  under caps  42  and transfer them to MIC. The robot gripper  110  configured like a fork and has a groove in an inner part to receive wings  46 . Plate handling gripper  110  embraces the wings  46  by its inner surface. The wins lean in a surface of gripper groove. In alternative embodiments gripper lean in slots  78  of transporting means.  
         [0254]     Centrifuge drum  132  and casing  134  in upper part configured with two apertures  136  and  138  so as to enable insertion of the robot gripper  110  and probe  100  within the centrifuge. Openings  136  and  138  closed by hatches or sash doors  140  and  142 .  
         [0255]     Centrifuge  24  in its inner part contains rotor  80  and buckets  50 . Robot  34  takes MIC  44  or multi-item plates  72  with tubes  40  and place inside buckets  50 , when centrifuge hatch  140  open. After centrifuging robot  34  moves away cap-covering  60  or multi-item plates  72  with caps  42  from centrifuge and tubes  40  are ready for direct centrifuge sampling.  
         [0256]     Compact analyzer  26  includes two reaction tanks  92  with reaction containers, reagent tanks  96  with reagent containers, reagent pipettes  98  and washing device. Analyzer  26  may equip with at least one turn away specimen probe  100 . Direct-centrifuge sampling method required automated rotor  80  indexing. When hatch  142  open, rotor  80  turns in determinate angle and adjust one bucket  50  near sample probes  100  position. LIS determinates specimen volume and tube arrangement in the said bucket  50 . Probes  100  suck specimens from the tubes  40  placed inside bucket  50  in a logical manner and transfer it to analyzer processing rings  92 . Using two specimen probes  100  decrease sampling time.  
         [0257]     After sampling all tubes  40  in the first bucket  50 , robot  34  removes MIC  44  or adapter  66  from bucket  50  and returns it to the turntable  38 . At this time rotor  80  turn on 90 or 180 degree and other adapter  66  with next separated tubes adjust near sample probes  100  position. After testing, robot  34  takes MIC  44  or universal adapter  66  by wings and move away from module to recapping station arranged near the module. In the recapping station (not shown) robot  34  place multi caps  68  or  76  on the MIC  44  or adapter  66  and remove tubes  40  to the storage refrigerator  32 .  
         [0258]     Said module does not require waiting area in a working surface since sorting deck, robot, rapid centrifuge and compact analyzer logically operate tubes arriving to the laboratory. With reference to  FIG. 22  shown the biological analytical module  22  comprises coupling centrifuge  24 , robotic unit  34 , turntable  152 , dispensing unit  36 , biological analyzer  38  and/or plate hotel and chiller  150 . Said module  22  uses direct centrifuge sampling method and provided with at least one swinging specimen probes  100 . Using two specimen probes  100  decrease sampling time. Robot  34  connected module  22  with sorting deck  20 . This module uses one robot  34  in the dispensing unit  36  and for loading—unloading tubes and microplates. Dispensing unit  36  arranges near centrifuge  24  sampling area. This embodiment decreases the module  22  sizes. Turntable  152  equipped with a bench  144  for placing MWC  44  and microplates  82 . Rotation mechanism  162  rotates turntable  152  about the rotation shaft coaxial with robotic revolving rod  130 .  
         [0259]     The robotic manipulator  34  comprises base  128 , connected with turntable  38  and revolving rod  130  coaxial with said base  128 . Robotic arm  146  connected with the rod  130 . Robot  34  load multi-item plates  72  with tubes  40  and microplates  82  provided with wings  46  or slots  78 . Robotic arm  146  comprises gripper  110  and dispensing pipette  158 . The gripper  110  configured like a fork and has a groove in an inner part to receive wings  46 . Plate handling gripper  110  embraces the wings  46  by its inner surface. The wins lean in a surface of gripper groove. In alternative embodiments gripper lean in slots of transporting means.  
         [0260]     Centrifuge drum  132  and casing  134  in upper part configured with at least one aperture  136  so as to enable insertion of the robot gripper  110  and probe  100  within the centrifuge inner area. Opening  136  closed by hatch or sash door  140 . Centrifuge  24  in its inner part contains indexing rotor  80  with buckets  50 . Robot  34  takes multi-item plates  72  with tubes  40  and place inside buckets  50 , when centrifuge hatch  140  open. After centrifuging robot  34  move away multi-item plates  72  with caps  42  from centrifuge and tubes  40  are ready for direct centrifuge sampling. Rotor  80  turns in determinate angle and stop one bucket  50  near specimen probe  100  position. LIS determinates specimen volume and tube arrangement in the said bucket  50 . Probe  100  suck samples from the tubes  40  placed inside bucket  50  in a logical manner and transfer it to microplate  82  placed on the bench  144  in a turntable  152 .  
         [0261]     In the dispensing unit  36  single or multi-item pipette  158  moves above microplate  82  and drop reagent inside microplate  82  wells. Robot  34  take said microplate  82  from the bench  144  and place inside plate hotel  150  or biological analyzer  38 .  
         [0262]     After sampling all tubes  40  in the first bucket  50 , robot  34  places multi-cap  68  or  76  on tubes  40 , removes said tubes  40  from bucket  50  and returns said multi-cap to the turntable  152 . At this time rotor  80  turn on 90 or 180 degree and other adapter  66  with next separated tubes adjust near sample probes  100  position for specimen sampling into said or next microplate  82 . After testing, robot  34  takes multi-cap  68  with tubes  40  and microplate  82  by wings and move away from module.  
         [0263]     Said Module does not require waiting area in a working surface since sorting deck, dispensing unit, rapid centrifuge and compact analyzer logically operate tubes arriving to the laboratory.