Abstract:
The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular in relation to protein-protein protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterisation or detection of a discontinuous binding site capable of inter-acting with a binding molecule, said library having been provided with a plurality of molecules, each molecule of said molecules comprising at least one first segment linked to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.

Description:
[0001]    The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to or interacting with a binding molecule, in particular in relation to protein-protein or protein-ligand interactions.  
           [0002]    Interactions between binding molecules, which in general are biomolecules, and their corresponding ligands, are central to life. Cells often bear or contain receptor molecules that interact or bind with a hormone, a peptide, a drug, an antigen, an effector molecule or with another receptor molecule; enzymes bind with their substrate; antibody molecules bind with an antigen, nucleic acid with protein, and so on. By “interact or bind” it is meant that the binding molecule and ligand approach each other within the range of molecular forces, and may influence each others properties. This approach takes the binding molecule and its ligand through various stages of molecular recognition comprising increasing degrees of intimacy and mutual effect: they bind.  
           [0003]    Binding molecules have this binding ability because they comprise distinct binding sites allowing for the recognition of the ligand in question. The ligand, in turn, has a corresponding binding site, and only when the two binding sites can interact by—essentially spatial—complementarity, the two molecules can bind. Needless to say that, molecules having three dimensions, binding sites are of a three dimensional nature, often one or more surface projections or protuberances of one binding site correspond to one or more pockets or depressions in the other, a three-dimensional lock-and-key arrangement, sometimes in an induced-fit variety.  
           [0004]    Sometimes, such a protuberance comprises a single loop of the molecule in question, and it is only this protuberance that essentially forms the binding site. In that case one often terms these binding sites as comprising a linear or continuous binding site, wherein a mere linear part of the molecule in question is in essence responsible for the binding interaction. This terminology in widely used to describe for example antibody-antigen reactions wherein the antigen comprises part of a protein sequence, a linear peptide. One than often speaks about a linear or continuous epitope, whereby the binding site (epitope) of the antigenic molecule is formed by a loop of consecutively bound amino acids. However, similar continuous binding sites (herein epitope and binding site are use interchangeably) can be found with receptor-antigen interactions (such as with a T-cell receptor), with receptor-ligand interactions such as with hormone receptors and agonists or antagonists thereof, with receptor-cytokine interactions or with for example enzyme-substrate or receptor-drug interactions, whereby a linear part of the molecule is recognised as the binding site, and so on. More often, however, such a protuberance or protuberances and depressions comprise various, distinct parts of the molecule in question, and it are the combined parts that essentially form the binding site. Commonly, one names such a binding site comprising distinct parts of the molecule in question a discontinuous or conformational binding site or epitope. For example, binding sites laying on proteins having not only a primary structure (the amino acid sequence of the protein molecule), but also secondary and tertiary structure (the folding of the molecule into alpha-helices or beta-sheets and its overall shape), and sometimes even quaternary structure (the interaction with other protein molecules) may comprise in their essential protuberances or depressions amino acids or short peptide sequences that lay far apart in the primary structure but are folded closely together in the binding site.  
           [0005]    Due to the central role binding molecules and their ligands play in life, there is an ever expanding interest in testing for or identification of the nature or characteristics of the binding site. Not only is one interested in the exact nature of the particular interaction between binding molecule and ligand in question, for example in order to replace or supplement binding molecules or ligands when needed; one is also interested in knowing approximating characteristics of the interaction, in order to find or design analogues, agonists, antagonists or other compounds mimicking a binding site or ligand involved.  
           [0006]    Versatile and rapid methods to test for or identify continuous epitopes or binding sites are known. Most, if not all nucleic acid detection techniques, and molecular libraries using these, entail hybridisation of an essentially continuous nucleic acid stretch with a complementary nucleic acid strand, be it DNA, RNA or PNA. Little attention has been paid to methods allowing rapid and straightforward identification of discontinuous binding sites of an essentially nucleic acid nature. Although plenty of such sites exist, think only of the lack of understanding surrounding ribosomal binding sites where ribosomal proteins bind to tRNA, of regulatory sites in promotor sequences, of interactions between polymerases and replicases between DNA and RNA, and so on, no molecular libraries exist that provide easy access to such sites. An early work in the peptide field is WO 84/03564, related to a method of detecting or determining antigenically active amino acid sequences or peptides in a protein. This work, providing the so-called Pepscan technology, whereby a plurality of different peptides is synthesised by linking with a peptide bond a first amino acid to a second, and so on, and on a second position in the test format yet another first amino acid is linked to a second, and so on, after which the synthesised peptides are each tested with the binding molecule in question, allows the determination of every continuous antigenic determinant or continuous epitope of importance in a protein or peptide sequence. Pepscan technology taken in a broad sense also provides for the testing for or identification of (albeit linear) peptides essentially identical with, analogous to or mimicking binding sites or ligands of a various nature (mimitopes, Geyssen at al, Mol. Immunol. 23:709-715, 1986).  
           [0007]    Pepscan technology allows identification of linear peptide sequences interacting with receptor molecules, enzymes, antibodies, and so on, in a rapid and straightforward fashion, allowing testing a great many peptides for their reactivity with the binding molecule in question with relatively little effort. The order of magnitude of testing capability having been developed with Pepscan technology (e.g. also due to miniaturisation of test formats, see for example WO 93/09872) furthermore allows at random testing of a multiplicity of peptides, leading to automated combinatorial chemistry formats, wherein a great many of binding molecules are being tested in a (if so desired at random) pattern for their reactivity with a molecular library of synthetic peptides representing potential continuous binding sites or ligands, allowing the rapid detection of particularly relevant molecules out of tens of thousands of combinations of molecules tested.  
           [0008]    However, for the testing of discontinuous or conformational binding sites to a binding molecule, no formats similar to or as versatile as Pepscan technology exist. Attempts to identify discontinuous epitopes by Pepscan technology are cumbersome. It does in general not suffice to merely extend synthesis of the test peptides by linking more amino acids to the existing peptide, and hoping that some of the thus formed longer peptides will fold in such a way that at least two distinct parts are presented in a discontinuous fashion and are recognised by a binding molecule. Than there is no way of finding out in a rapid and straightforward fashion that the binding is indeed through a discontinuous binding site, it might be that just a longer single loop is responsible for the binding.  
           [0009]    Some additional possibilities are provided by testing synthetic peptide sequences that have been designed to comprise two previously identified parts of a binding site, each part in essence being linear and being part of a larger linear peptide. Early work herein was done by Atassi and Zablocki (J. Biol. Chem 252:8784, 1977) who describe that spatially or conformationally contiguous surface residues (which are otherwise distant in sequence) of an antigenic site of egg white lysozyme were linked by peptide bonds into a single peptide which does not exist in lysozyme but attempts to simulate a surface region of it. However, their technique, called surface simulation synthesis, requires the detailed knowledge of the three-dimensional structure of the protein under study and a full chemical identification of the residues constituting the binding site at beforehand, as well as their accurate conformational spacing and directional requirements.  
           [0010]    In the same fashion, Dimarchi et al (Science 232:339-641, 1986) describe a 38 to 40 amino acid long synthetic peptide consisting of two previously identified separate peptidyl regions of a virus coat protein. The peptide was synthesised using common peptide synthesis technology (Merrifield et al., Biochemistry 21, 5020, 1982) by adding subsequent amino acids with a peptide bond to an ever growing peptide resulting in a peptide wherein the two peptidyl regions were connected by a diproline spacer presumably functioning as indication of a secondary structural turn, thereby thus providing a two-part epitope or binding site.  
           [0011]    However, it is clear that when one already at beforehand has to know the sequence of the (in this case only) two relevant parts, in order to provide the desired discontinuous binding site, it excludes the feasibility to provide (desirably in a random fashion) a whole array of merely potential discontinuous binding sites for large scale testing. Furthermore, a major drawback of these strategies is that again only linear epitopes or dominant binding regions of discontinuous eptitopes can be mimicked adequately. For the complete synthesis of a discontinuous binding site, all the contributing parts have to be arranged in the proper comformation to achieve high-affinity binding, therefore, single parts of discontinuous binding sites have to be linked.  
           [0012]    Fifteen years after Dimarchi, Reineke et al (Nature Biotechnology, 17:271-275, 1999) provided a synthetic mimic of a discontinuous binding site on a cytokine and a method to find such a discontinuous binding site that allowed for some flexibility and somewhat larger scale of testing, wherein positionally addressable peptide collections derived from two separate regions of the cytokine were displayed on continuous cellulose membranes, and substituted in the process to find the best binding peptide. After selection of the “best reactors” from each region, these were combined to give rise to another synthetic peptide collection (comprising peptides named duotopes) that again underwent several rounds of substitutions.  
           [0013]    Reineke et al hereby provide synthesis of peptide chains comprising duotopes, however, again selected after previous identification of putative constituting parts with Pepscan technology, thereby still not allowing testing discontinuous binding sites in a rapid and straight forward fashion.  
           [0014]    However, as indicated before, protein domains or small molecules that mimic binding sites are playing an increasing role in drug discovery, diagnostics and biotechnology. The search for particular molecules that bind to a binding site and mimic, or antagonise the action of a natural ligand has been initiated in many laboratories. As indicated before, attempts to find such structures in synthetic molecular libraries often fail because of the essentially discontinuous nature and spatial complementarity of most binding sites. Thus, for the many more cases where the binding site may essentially be discontinuous improved means and methods to identify these sites are needed, and in particular means and methods are needed that allow testing for discontinuous binding sites whereby said parts need not necessarily first be selected by previous identification as a putative or even only tentative constituting part of the desired discontinuous binding site, but bear only the potentiality of being part of that site by being a molecule with more or less distinct features per se.  
           [0015]    The invention provides a method for producing a molecular library comprising providing said library with a plurality of molecules wherein said molecules have essentially been produced by segmental linkage, that is by linking (di-, tri, oligo- or multimeric) segments of for example nucleic acids or peptides, instead of by sequentially synthesising said molecules which is done traditionally. The invention thus provides a molecular library that, albeit also suited for detecting or screening for continuous binding sites, is now particularly well suited for detecting or screening for discontinuous binding sites, in particular in relation to binding molecule-ligand interactions such as for example protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions.  
           [0016]    Said segments can of course be selected at random from any set of di-, tri,- or oligomeric sequences, such as from di-, tri,- or oligonucleotides, or di-, tri-, or oligopeptides, but sometimes it may be preferred to include at least one specific segment in said segment, specific in a sense that it has been selected from among known segments or distinct parts of biomolecules, such as parts of genes, proteins, enzymes, nucleic acids or unique fragments thereof, proteins involved in up- or downregulation of translation, t-RNAs, SNRP&#39;s, antibodies, antigens, receptors, transport proteins, transcription factors or factors involved in up- or downregulation of transcription, promotor sequences such as but not necessarily restricted to the well known TATA-box elements, repressor sites, operator sites and other control elements, polymerases, replicases, in short, from among known segments or distinct parts of binding molecules known or suspected to be involved in binding via a discontinuous binding site. Such known segments or parts thereof may of course be already known as parts constituting a discontinuous binding site, however, previous identification as o, such is in essence not necessary, since screening for such sites with a molecular library according to the invention allows rapid and straightforward identification of said constituting segments or parts thereof.  
           [0017]    Screening such a library can easily be envisioned when the library&#39;s molecules differ only in that constituting segments are chosen in an overlapping fashion, whereby a first segment from a distinct biomolecule is linked to a second, and to a third, and to a fourth segment, and a second is linked to a third, and to a fourth, and so on, if so required until all possible segments of said biomolecule have been linked two-by-two (or three-by-three, or even more) together, which allows for a systematic screening of said biomolecule. However, linking in a overlapping fashion is of course not required, random segment links will provide valuable information about binding sites as well.  
           [0018]    The invention thus provides a method for producing a molecular library for identification or detection of a binding site capable of interacting with a binding molecule, and thus for the identification of a molecule as a binding molecule, said method comprising providing said library with a plurality of molecules, further comprising generating at least one of said molecules, preferably a greater part, most preferably essentially all of said molecules, by at least linking a first segment to a second segment, for example a segment which comprises a dimer, trimer, oligomer or multimer.  
           [0019]    Existing libraries, be it of for example nucleic acid (containing a repetitive back-bone of nucleotides, nucleosides or peptide nucleic acid, or combinations of these) or amino acid (containing a repetitive back-bone of amino acids) nature have in general in common that they comprise oligomeric or multimeric molecules, such as stretches of nucleic acids or amino acids, that have been produced by sequentially linking, in a repetitive fashion, one monomer (e.g. a nucleotide or an amino acid) to another, until a (in essence polymeric) molecule of the desired length has been obtained.  
           [0020]    Essentially, existing nucleic acid libraries comprise nucleic acids that are synthesised sequentially, by adding one nucleotide or nucleoside at a time to the growing stretch, and existing peptide libraries comprise peptides that are synthesised sequentially, by adding one amino acid at the time to a growing stretch, until the desired length has been reached. With nucleic acids said monomers are essentially selected from a limited set of well known nucleotides, with peptides, said monomers are essentially selected from a well known set of amino acids. Not only naturally occurring monomers are used, synthetic nucleotides, such as peptide nucleic acid (PNA) molecules, or non-naturally occurring amino acids, or even D-amino acids, are routinely uses as monomers by which the essentially polymeric molecules are generated or produced, using a method that is essentially conform the sequential synthesis of polymers from monomeric molecules in nature.  
           [0021]    The invention provides the recognition that essentially using dimeric or even larger (tri-, oligo-, or multimeric) segments, and thus stepping out of fashion with sequential nucleic acid or protein synthesis as it essentially occurs in nature, offers distinct advantages. It not only provides a faster method to arrive at a molecule composed of various segments, it also provides for fast and efficient shuffling of segments to generate a molecule repertoire for the desired library. The invention for example provides a method wherein synthesis is started with a monomer to which a second segment comprising a dimer, such as a dinucleotide or a dipeptide is added. Herein, a segment comprising a dimer at least consists of a dimer but can also be for example a trimer, or any other multimer, linking monomers of any nature, as required. Of course, once two segments have been linked, further segments can be linked. In a preferred embodiment, to speed up further synthesis, or to be able to select distinct desired segments, the invention provides a method wherein said first segment also comprises a dimer, and in a yet even more preferred method, further segments comprise dimers as well. In a preferred embodiment, said dimer comprises a dinucleotide or dipeptide, but of course other dimers can be made also. The invention is further explained in the detailed description where several of the examples relate to libraries comprising molecules wherein each of said segments comprises a peptide, such as a tri-, a penta, an octa-, or nonapeptide; it is however also provided by the invention to use segments of a varied nature, e.g. wherein one comprises a nucleic acid and another comprises a peptide, to better mimic binding sites that are for example found on nucleic acid-protein complexes.  
           [0022]    In a preferred embodiment, as for example shown in the examples, the invention provides a method wherein said first segment is linked by a thioether bond to said second segment, however, the invention is of course not limited thereto.  
           [0023]    Nucleotide/side segments can for example be covalently linked or ligated by splicing enzymes or ligases, or by overlapping a first segment and the second segment with an in essence relatively short nucleotide strand that is partly complementary to both segments.  
           [0024]    The invention thus provides a molecular library allowing testing for, identification, characterisation or detection of a continuous or discontinuous binding site capable of interacting with a binding molecule, said library having been provided with a plurality of molecules, each molecule of said molecules preferably comprising at least one first segment linked to a second segment, wherein at least said second segment previously existed as dimer or multimer. Preferably, each segment or part thereof having the capacity of being a potential single part of a discontinuous binding site, preferably wherein each of at least a first and a second segment or part thereof represents a potential single part of a discontinuous binding site. Such a library can for example exist of a synthetic molecular library made by chemical linking of segments.  
           [0025]    Preferably, such segments have distinct features, for example by being in essence segments that are, comprise or mimic molecular components of living organisms, such as (combinations of) nucleotides, sugars, lipids, amino acids, nucleic acid molecules (DNA or RNA), peptide nucleic acid molecules (PNA), carbohydrates, fatty acids or fats.  
           [0026]    Herewith the invention provides synthesis of molecules comprising separate segments potentially representing at least two distinct parts of a discontinuous binding site, said parts not necessarily first being selected after previous identification of potential constituting parts, thereby allowing testing for discontinuous binding sites in a rapid and straight forward fashion.  
           [0027]    The invention thus now allows identifying discontinuous binding sites of receptor molecules that interact or bind at that contact site with a hormone, a peptide, a drug, an antigen, an effector molecule or with another receptor molecule, of enzymes that bind with their substrate, of antibody molecules that bind with a binding site on an antigen, nucleic acid that binds with protein, and so on. In a preferred embodiment of the invention, at least one of said segments comprises a peptide, another segment being for example DNA, RNA, PNA, carbohydrate, a fatty acid, an hormone or an organic molecule altogether. In one embodiment of the invention, all segments comprise a peptide, said segments preferably linked by a stable (non-naturally) occurring non-peptide bond or linker. In this way a plurality of different peptides is synthesised by linking a first peptide segment to a second, and so on, and on a second position in the test or library format yet another first peptide segment is linked to a second, and so on, after which the synthesised peptides are each tested with the binding molecule in question, allowing the determination of a discontinuous antigenic determinant or discontinuous epitope of importance in a protein or peptide sequence. Said peptide segment comprises at least 2 amino acids, and can in principle be as long as desired, e.g. containing a hundred amino acids or even more. In preferred practice, said peptide segment comprises from 3 to 30, preferably from 4 to 20, even more preferably from 5 or 6 to 12 to 15 amino acids, such as 9 or 12 amino acids. Separate segments of course do not necessarily have to be of equal length.  
           [0028]    Furthermore, peptide segments to be linked together can be selected at random, or under guidance of (a) known protein or peptide sequence(s). Selection at random provides a random library according to the invention. Selection from known protein or peptide sequences is for example useful when it is desired to find out whether a discontinuous binding site is composed of distinct sites or parts present at distinct proteins or peptides, for example in a protein complex to which a particular binding molecule can bind. Selection of various peptide segments from one known protein or peptide sequence is useful when it is desired to find out whether a discontinuous binding site is composed of distinct sites or parts present at one protein or peptide, for example at a folded protein to which a particular binding molecule can bind. Selection of peptide segments can be done by selecting overlapping peptides from such a known sequence. Overlapping peptides can have for example all but one or two amino acids in common, preferably overlapping in a contiguous fashion, or can overlap with only one or several amino acids. For a quick scan for discontinuous binding sites on a known protein, it is for example useful to select nonapeptide segments from said protein sequence, of which one has for example a 5-amino acid long overlap with another peptide segment. Equally useful, however, is to select tripeptide segments from said sequence having an overlap of only one amino acid, and use three, or even more segments in constructing the putative binding site molecule to which the to be tested binding molecule can bind.  
           [0029]    Of course, such selection strategies are equally applicable to segments of a different nature, nucleic acid segments, comprising a certain number of nucleotides, such as 5, 7, 9, and so on, can be selected from known nucleic acid sequences comprising sought after discontinuous binding sites, each segment selected from a certain position in said known nucleic acid sequence, if desired also in a overlapping fashion. Said nucleic acid segment comprises at least 2 nucleotides (be it DNA, RNA or PNA, or functional equivalents thereof), and can in principle be as long as desired, e.g. containing a hundred nucleotides or even more. In preferred practice, said nucleic segment comprises from 3 to 30, preferably from 4 to 20, even more preferably from 5 or 6 to 12 to 15 nucleotides, such as 9 or 12 nucleotides. Separate segments of course do not necessarily have to be of equal length, and, as said before, can even be of a different nature, e.g. peptide with DNA.  
           [0030]    Herein a peptide bond is being defined as an amide bond between an alpha-amino group of one amino acid or peptide and an alpha-carboxyl group of another amino acid or peptide. A non-peptide bond comprises any other amide bond or non-amide bonds. The links or bonds can be formed using many combinations of strategies of for example peptide or nucleotide chemistry and selective ligation reactions as known in the art. Ligation chemistry has been published, for instance, by groups of Kent (Ph. E. Dawson et al., Synthesis of Proteins by Native Chemical Ligation, Science 266 (1994) 776-779), Tam (J. P. Tam et al., Peptide Synthesis using Unprotected Peptides through Orthogonal Coupling Methods, Proc. Natl. Acad. Sci. USA 92 (1995) 12485-12489; C. F. Liu et al, Orthogonal Ligation of Unprotected Peptide Segments through Pseudoproline Formation for the Synthesis of HIV-1 Protease Analogs, J. Am. Chem. Soc. 118 (1996) 307-312; L. Zhang &amp; J. P. Tam Thiazolidone Formation as a General and Site-specific Conjugation Method for Synthetic Peptides and Proteins, Analytical Biochemistry 233 (1996) 87-93), and Mutter (G. Tuchscherer &amp; M. Mutter, Protein Design as a Challenge for Peptide Chemists, J. Peptide Science 1 (1995) 3-10; S. E. Cervigni et al, Template-assisted Protein Design: Chimeric TASP by Chemoselective Ligation, Peptides: Chemistry, Structure and Biology, P. T. P Kaumaya &amp; R. S. Hodges eds, Mayflower (1996) 555-557).  
           [0031]    Possible strategies for the formation of links as preferably provided by the invention are for example are:  
           [0032]    1. Said link with a segment or segments is formed using a homo- or hetero-bifunctional linking agent (S. S. Wong: Chemistry of Protein Conjugation and Cross-Linking, CRC Press Inc, Boca Raton, Fla. USA 1991). In this construction a reactive group in one segment is used to react with one part of the bifunctional linking agent, thus facilitating the second part of the linking agent to react with a reactive group from a second segment. For instance, a linker like MBS (m-maleinimidobenzoic acid N-hydroxysuccinimide ester) can be used to react via its active ester (succinimide) with an amino group of one segment and via its maleinimide group with a free thiol group from a second segment. In this strategy preferably no other free amino- or thiol groups should be present in the first segment and preferably no other free thiol groups are present in the second segment. In order to accomplish this, the amino or thiol groups that should be involved in the reaction can be deprotected selectively, for instance, by using a side chain protecting group that can be cleaved by a mild reagent like 1% trifluoroacetic acid, which leaves other side chain protecting groups intact.  
           [0033]    2. Said link is formed by introduction of a modified amino acid in the synthesis of one or more segments. Amino acids can be modified, for instance, by introduction of a special group at the side-chain or at the alpha-amino group. A modification at the alpha-amino group leads to an amide or backbone modified peptide (see fort example Gillon et al., Biopolymers, 31:745-750, 1991). For instance, this group can be a maleinimido group at the side chain amino group of lysine. At the end of the peptide synthesis this group will react fast and selective with a thiol group of a second segment. Tam et al. (PNAS 92:12485-12489, 1995) described a synthesis of a peptide with a lysine residue that was modified in the side chain with a protected serine residue. After deprotection and selective oxidation using periodate, the alpha-amino, beta-hydroxy function of the serine was converted into an aldehyde function that could be ligated selectively with another thiol-bearing segment. Also peptide backbone links, via groups attached to the amide groups of the peptide, can be used to link segments (Bitan et al., J. Chem. Soc. Perkin Trans. 1:1501-1510, 1997; Bitan and Gilon, Tetrahedon, 51:10513-10522, 1995; Kaljuste and Unden, Int. J. Pept. Prot. Res. 43:505-511, 1994).  
           [0034]    3. Yet another way to form said link is to synthesise a segment, such as a peptide, with a modified N-terminus. For instance, an N-terminal alpha-haloacetamido group can be introduced at the end of the synthesis. This group reacts fast and selectively with a second segment, i.e. another peptide, which contains a thiol group. For instance, the first segment is synthesised with an N-terminal bromoacetamide and the second segment with a cysteine. Although most alpha-haloacetamide groups, like chloro-, bromo-, or iodoacetamide, will react with thiol groups, in those cases where speedy assembling is required, the bromoacetamide group is preferred because of its ease of introduction and fast and selective reaction with thiol groups.  
           [0035]    Furthermore, the invention provides the possibility to address the link in every position of the first and/or the second or consecutive segment. For instance, for peptide segments sets of peptides are synthesised in which a cysteine or a side-chain modified lysine, both amino acid residues being able to ligate selectively with another segment, shifts from the N-terminal amino acid position one by one to the C-terminal amino acid position. Combinations of these possibilities will again lead to new libraries as provided by the invention.  
           [0036]    In a preferred embodiment, the invention provides a library wherein said molecules are positionally or spatially addressable, e.g. in an array fashion, if desired aided by computer directed localisation and/or recognition of a specific molecule or set of molecules within the dimensions (e.g. plane or surface) of the support of the library used. In an array, said molecules are for example addressable by their positions in a grid or matrix.  
           [0037]    A preferred embodiment of the invention further allows upscaling of the synthesis concerning the number of constructs on for example a solid support per cm 2 . To facilitate generation of a great many possible constructs, containing for example molecules comprising at least two peptide segments of a protein, many thousands of peptide constructs are made. For instance, when all constructs, in which both segments are for instance 12 amino acids long, are derived from a small protein with a length of 100 amino acid residues are needed, already 89×89=7921 peptide constructs are made, if the segments are only linked, for instance, via the C-terminus of the first segment and the N-terminus of the second segment using only one type of link. For a protein with a length of 1000 amino acid residues at least 989×989=978121 constructs are made. For efficient ELISA testing of these numbers of constructs, high construct densities on the solid support are preferred. High densities of constructs on a solid support are provided by the invention, wherein for instance, (a layer of) a first segment with a bromoacetamide group at the N-terminus is synthesised on a surface of, for instance, 1 cm 2 . On this peptide-functionalised surface of the support a set of, for instance, 10, preferably 50, preferably 100, or more second peptide segments containing a free thiol group are spotted or gridded, in a positionally or spatially addressable way, giving, after coupling, so many different peptide constructs. Preferably, said support is provided with a surface wherein patches or pixels are interspersed within areas that are materially distinct from said pixels, a so-called pixel array. In particular, the invention provides a support (herein also called a pixel array) wherein the support surface material is of a varied or discontinuous nature as regards to hydrophilicity. In such a support for a high-density micro-array as provided herein, patches or pixels of relative hydrophilicity are preferably interspersed with areas of relative hydrophobicity. Of course there need not be a sharp border between patches and the surrounding area, it is sufficient when distinct material differences or discontinuities exist between the centre of a patch and the middle line of a surrounding area, whereby there is a more or less gradual material change in between. Patches and surrounding areas may be in strict matrix or grid format, but this is not necessary. Patches are in general somewhat, but preferably at least one or two dimensions smaller than the size of the circumference of the positioned droplets or spots of first member molecules that in a later phase will be provided to the support surface, that is preferably at least 3-5, and more preferably at least 10-20 of such e.g. hydrophilic patches fit within the circumference of a later spotted solution of a first member, be it nucleic acid or peptide or any other (bio-)molecule or combination thereof. Of course, a one-to-one fit of patch to droplet or spot is also feasible, even when the patch is larger than a spot, but not necessary and neither is it necessary to apply or provide for the patches in an overly regular pattern. When a droplet or spot is provided, the interspersed hydrophobic character of the support surface will limit the diffusion of any aqueous solution, and thus also, again in a later phase, the diffusion of a solution of an optically detectable substrate (be it as precipitate or as solution) formed after the enzymatic reaction that took place where a first member is bound to a second member of a binding pair, whereby the presence of the relatively hydrophilic patch or patches within said droplet or spot circumference allows said substrate to be positioned or detectable at all.  
           [0038]    Spotting can, for instance, be done using piezo drop-on-demand technology, or by using miniature solenoid valves. Gridding can, for instance, be done using a set of individual needles that pick up sub-microliter amounts of segment solution from a microtiter plate, containing solutions comprising the second segments. After the linking reaction, subsequent deprotection and extensive washing of the support to remove uncoupled peptide gives at least a peptide construct density as large as 10 to 50; or even 100 to 200, or up to 50 to 1000 spots per cm 2 . This density allows to screen a great many possible peptide constructs of said proteins for binding with an antibody. For example: in a preferred embodiment 20000 to 100.000 constructs are made on 1000 cm 2 , typically the surface is than screened for binding in ELISA with 100 ml of antibody solution, containing 1-10 μg of antibody/ml. For example, indirect or direct fluorescence detection allocates antibody binding constructs. Direct fluorescence detection with confocal scanning detection methods for example allows antibody detection on spots generated with droplets peptide-solution in the sub-nanoliter range, making even higher construct densities feasible. Of course, nucleic acid libraries can be made in a similar fashion.  
           [0039]    Furthermore, the invention provides a solid support, preferably a discontinuous matrix array support as explained below, comprising a library according to the invention, said solid support allowing presentation of a potential discontinuous or conformational binding site or epitope to a binding molecule, said solid support having been provided with a plurality of molecules, each molecule of said molecules being a possible representative of said binding site or epitope and for example comprising at least one first peptide or nucleotide covalently linked by a spacer to a second peptide or nucleotide, said spacer comprising at least one non-peptide linkage. In a preferred embodiment, said solid support comprises at least a spot or dot (e.g. putative binding site or peptide construct) density as large as 10, 20, or 50, or even 100, 200, or up to 500 or even 1000 spots per cm 2,  preferably wherein said spots or dots are positionally or spatially addressable.  
           [0040]    The invention further provides a method to screen for, i.e. test, identify, characterise or detect a discontinuous binding site capable of interacting with a binding molecule, comprising screening a library as provided by the invention with binding molecules, such as there are for instance antibodies, soluble receptors, which contain a Fc-tail or a tag for detection, receptors on cells, biotinylated molecules or fluorescent molecules. Alternative segments could comprise, for instance, carbohydrates, non-natural amino acids, PNA&#39;s, DNA&#39;s, lipids, molecules containing peptide bond mimetics. In particular, the invention provides a method to screen for a discontinuous binding site capable of interacting with a binding molecule, comprising screening a library according to the invention with at least one binding molecule and detecting binding between a member of said library and said binding molecule. In a preferred embodiment, said binding is detected immunologically, for example by ELISA techniques.  
           [0041]    Furthermore, the invention combines the advantages of high density arraying (testing a lot of binding events in one go) and enzyme-linked assays (very sensitive) allowing to detect more discontinuous binding sites more rapidly. Micro-array systems are provided herein that allow to work with enzyme-linked assays to detect the molecule of interest on high-density supports. Such testing high densities of constructs a solid support in a enzyme-linked assay is provided by the invention, wherein for instance a first member is provided to or synthesised on a surface of the support in a density of, for instance, 10 or preferably 50, but more advantageously preferably 100, or more, such 200-500 or even 1000 spots per square centimeter. Said first binding pair members are for example spotted or gridded, in a positionally or spatially addressable way, giving so many different constructs on the support with which a second member or binding molecule can react. Of course, spots can overlap, as long as the constituting collection of first member molecules are spatially addressable and distinct. Spotting can, for instance, be done using piezo drop-on-demand technology, or by using miniature solenoid valves. Gridding can, for instance, be done using a set of individual needles that pick up sub-microliter amounts of segment solution from a microtiter plate, containing solutions comprising the first members. When testing peptides, after the linking reaction, subsequent deprotection and extensive washing of the support to remove uncoupled peptide gives at least a peptide construct density as large as 25 to 50, or even 100 to 200, or up to 500 to 1000 spots per cm 2 . This density allows to screen a great many possible peptide constructs of said proteins for binding with an antibody. For example: in a preferred embodiment 25000 to 100.000 constructs are made on 1000 cm 2 , typically the surface is than screened for binding in enzyme-linked assay—be it directly or indirectly—wherein a fluorescent substrate is generated with 100 ml of enzyme-labelled probe solution, containing 1-10 μg of probe/ml and subsequent development of an optically detectable substrate with established techniques. For example, indirect or direct fluorescence detection allocates antibody binding constructs. Direct fluorescence detection with confocal scanning detection methods for example allows antibody detection on spots generated with droplets peptide-solution in the sub-nanoliter range, making even higher construct densities feasible. Of course, nucleic acid libraries can be made in a similar fashion, using enzyme-labelled nucleic acid probes.  
           [0042]    Furthermore, the invention provides a support for a micro-array suitable for testing binding of a first member molecule, wherein said first member is provided by segment synthesis, within an array or library of tentative first member binding molecules with a second member binding molecule said support provided with a surface wherein patches are interspersed within areas that are materially distinct from said patches. In particular, the invention provides a support (herein also called a discontinuous matrix array) wherein the support surface material is of a varied or discontinuous nature as regards to hydrophilicity. In such a support for a high-density micro-array as provided herein, patches of relative hydrophilicity are preferably interspersed with areas of relative hydrophobicity. Of course there need not be a sharp border between patches and the surrounding area, it is sufficient when distinct material differences or discontinuities exist between the centre of a patch and the middle line of a surrounding area, whereby there is a more or less gradual material change in between. Patches and surrounding areas may be in strict matrix or grid format, but this is not necessary. Patches are in general somewhat, but preferably at least one or two dimensions smaller than the size of the circumference of the positioned droplets or spots of first member molecules that in a later phase will be provided to the support surface, that is preferably at least 3-5, and more preferably at least 10-20 of such e.g. hydrophilic patches fit within the circumference of a later spotted solution of a first member, be it nucleic acid or peptide or any other (bio-)molecule or combination thereof. Of course, a one-to-one fit of patch to droplet or spot is also feasible, even when the patch is larger than a spot, but not necessary and neither is it necessary to apply or provide for the patches in an overly regular pattern. When a droplet or spot is provided, the interspersed hydrophobic character of the support surface will limit the diffusion of any aqueous solution, and thus also, again in a later phase, the diffusion of a solution of an optically detectable substrate (be it as precipitate or as solution) formed after the enzymatic reaction that took place where a first member is bound to a second member of a binding pair, whereby the presence of the relatively hydrophilic patch or patches within said droplet or spot circumference allows said substrate to be positioned or detectable at all. The preferred patches as provided herein may also be described as pixels within the spot where finally the optically detectable or fluorescent substrate will be located. Of course, if so desired patches may be hydrophobic where the surrounding area is relatively hydrophilic, when for example solutions or (optically detectable) markers are tested of a more hydrophobic nature.  
           [0043]    In a preferred embodiment, said support as provided herein comprises at least a spot or dot (e.g. a collection of first member molecules such as a nucleic acid or peptide construct) density as large as 25 or 50, or even 100, 200, or up to 500 or even 1000 spots per cm 2  preferably wherein said spots or dots are positionally or spatially addressable, each of said spot or dot covering at least one patch, but preferably from 3-5, or even from 5-15 or more patches or pixels.  
           [0044]    Hydrophilic patch size can be modified by selecting the appropriate support material, such as polyethylene or polypropylene or another relatively hydrophobic plastic material, to begin with, or by providing it with patches in the desired size, e.g. by utilizing print technology. Below, a support surface is produced from a relatively hydrophobic polypropylene surface upon which grafts are provided that form the relatively hydrophilic patches. Preferred is to make the grafts with polyacrylic acid, which has an excellently suitable hydrophilic nature. Patch size can be influenced by selecting the appropriate roughness of a polyethylene or polypropylene starting material, said roughness can also be modulated by sanding or polishing, or by any other mechanical (printing) or chemical (etching) method to modulated a surface on which the hydrophilic patches are to be generated. Of course, the smaller the hydrophilic patch size is, the smaller the droplets to be applied can be, preferably up to the size where at least one patch falls within the circumference of the droplets applied.  
           [0045]    The invention also provides a method for determining binding of a first member molecule within an library of tentative first member binding molecules with a second member binding molecule comprising use of a support according to the invention, in particular a method comprising providing said support with spots comprising said tentative first member binding molecules, providing a second member binding molecule and detecting binding of a first member molecule with said second member binding molecule.  
           [0046]    Preferably, said binding is detected with an optically detectable marker for example wherein said marker comprises a fluorophore, directly or indirectly labelled to a probe such as a nucleic acid or antibody, thus allowing a support according to the invention to be used in any type of micro-array; prevention of diffusion is always welcome to avoid or circumvent problems such as signal overload, however, in a preferred embodiment, the invention provided a method wherein binding pairs are detected via enzyme-linked-assay techniques, where otherwise diffusion or leakage would be much harder to overcome, the further advantage being that enzymetic detection is much more sensitive, thereby allowing to include less copies of tentative first member molecules to be spotted in one spot, thus in general decreasing spot-size, thus allowing to increase spot density, without having to give in on sensitivity. Enzymatic detection can be up to 10-1000 times more sensitive as detection of directly labelled probes.  
           [0047]    Suitable enzyme-substrate combinations and methods for use in a method according to the invention are for example found with U.S. Pat. No. 4,931,223 wherein processes are disclosed in which light of different wavelengths is simultaneously released from two or more enzymatically decomposable chemiluminescent 1,2-dioxetane compounds, said compounds being configured, by means of the inclusion of a different light emitting fluorophore in each of them, to each emit light of said different wavelengths, by decomposing each of said compounds by means of a different enzyme. Also, Bronstein et al. BioTechniques 12 #5 (May 1992) pp. 748-753 “Improved Chemiluminescent Western Blotting Procedure” suggests an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction which includes the reaction, with an enzyme, of a dioxetane so that the enzyme cleaves an enzyme-cleavable group from the dioxetane to form a negatively charged substituent bonded to the dioxetane, the negatively charged substituent causing the dioxetane to decompose to form a luminescent substance. Cano et al. J. App. Bacteriology 72 (1992)provided an example of nucleic acid hybridization with a fluorescent alkaline phosphatase substrate, which advantagously can be used in the invention as well, and Evangelista et al. Anal. Biochem. 203 (1992) teaches alkyl- and aryl-substituted salicyl phosphates as detection reagents in enzyme-amplified fluorescence DNA hybridization assays. In the detailed description herein use is made of a fluorescent substrate for alkaline phosphatase-based detection of protein blots, for use with fluorescence scanning equipment such as Molecular Dynamics FluorImager or Storm instruments, generally known as Vistra ECF and generally only deemed suitable for use in Western blotting, dot and slot blotting applications. The enzymatic reaction of alkaline phosphatase dephosphorylates said ECF substrate to produce a fluorescent product which is, as shown herein, detectable in a method according to the invention. However, not only alkaline phosphatase detection based is provided herein, the invention also provides a method according to the invention wherein a substrate for evaluating glycosidic enzymes comprising a fluorescein derivative such as known from U.S. Pat. No. 5,208,148 is used, which bears a lypophillic character and therefor will preferably reside in hydrofobic areas of the surface.  
           [0048]    Furthermore, the invention provides a synthetic molecule comprising a binding site(i.e. located on the detected first member molecule or derivatives thereof) or a binding molecule comprising a binding site identifiable or obtainable by a method according to the invention. Furthermore, use of a support or a method according to the invention for identifying or obtaining a synthetic molecule comprising a binding site or for identifying or obtaining a binding molecule capable of binding to a binding site is provided and the use of such an obtained molecule for interfering with or effecting binding to a binding molecule.  
           [0049]    By detecting binding to a specific member of said library, the invention provides said member, a synthetic molecule comprising a discontinuous binding site identifiable or identified or obtainable or obtained by a method according to the invention. Thus the invention provides use of a library according to the invention, use of a solid support according to the invention, or use of a method according to the invention for identifying or obtaining a synthetic molecule comprising a discontinuous binding site or a binding molecule capable of binding therewith. Because now discontinuous binding sites are provided, such a synthetic molecule can advantageously be used in vitro or in vivo for finding a binding molecule, and for effecting and/or affecting binding to a binding molecule, for example to interact or bind with receptor molecules that normally interact or bind with a hormone, a peptide, a drug, an antigen, with an effector molecule, with an agonist, with an antagonist, or with another receptor molecule; with enzymes that normally bind with their substrate; with antibody molecules, with nucleic acid, with protein, in short, with biomolecules. The invention is further explained in the detailed description without limiting the invention.  
       
    
    
     FIGURE LEGENDS  
       [0050]    [0050]FIG. 1. A) ELISA results of a library of constructs of a protein, synthesised in 3 μl wells of a 455 wells microtiter plate tested against a protein specific monoclonal antibody (monoclonal antibody-01) which binds human Follicle stimulating hormone (hFSH). Construct 1: sequence[1-11]-Cys coupled to bromoacetamide-sequence[14-25]; construct 2: sequence[2-12]-Cys coupled to bromoacetamide-sequence[15-26]; and so on. The reacting peptide is shown. It is part of hFSH as illustrated in FIG. 1B. B) Three dimensional model of hFSH. The identified epitope is shown in black. C) replacement-analysis of the identified epitope. The essential amino acids are part of both parts of the peptides.  
         [0051]    [0051]FIG. 2. A) Microturisation of spots of peptide constructs. Constructs were tested against the same monoclonal antibody-01 as was tested in FIG. 1. Binding was made visible using indirect fluorescence detection. Peptide 1, sequence [139 -150] with an N-terminal bromoacetamide, was synthesised on the complete surface. Peptide construct 6-1 is the same as construct 125 in FIG. 1. Peptides 2 up to 8, containing a cysteine residue, were spotted in different volumes ranging from 1 μl to 0.25 nl using piezo drop-on-demand technology. In I the sequences are shown; in II the spots are shown; in III the controls are shown, on the left a test with monoclonal antibody-03 that recognizes the peptide ADSLYTYPVATQ which is present on the whole square, on the right monoclonal antibody-01 which does not recognize ADSLYTYPVATQ but requires the longer peptides as shown by the spots in I. B) Three dimensional model of hFSH. The identified epitope is shown in black.  
         [0052]    [0052]FIG. 3. A) Schematic presentation of a “standard” 24-mer scan in creditcard minicards. 12345678901 (building block 2) and NOPQRSTUVWXY (building block 1) represent successive sequences derived from a protein. Both building blocks are linked via a thioether bridge, formed by reaction of a free thiol function of a C-terminal cysteine residue (C) in building block 2 and a bromoacetamide group ($) at the N-terminus of building block 1. In this scan both sequences are shifted simultanuously by steps of one amino acid residue through the complete protein sequence to obtain the complete library. SS=Solid Support. B) Working example with anti-hFSH monoclonal antibody-02 C) Three dimensional model of HFSH. The identified epitope is shown in black.  
         [0053]    [0053]FIG. 4. A) Schematic presentation of a positional complete matrix scan. This scar is similar to the scans shown in FIG. 5, however, no cysteine residue was added to one of the termini of the second building block, but instead each residue of the second building block sequence was substituted one by one by a cysteine residue. B) Working example with anti-hFSH monoclonal antibody-02. C). Three dimensional model of hFSH. The identified epitope is shown in black.  
         [0054]    [0054]FIG. 5. Working example of coupling of a long peptide (24-mer) that is recognized by anti-hFSH monoclonal antibody-01 to all overlapping 15-mers covering hFSH. The example illustrates that all peptides were coupled.  
         [0055]    [0055]FIG. 6. A) Schematic presentation of a head-to-tail complete matrix scan. 12345678901 and ABCDEFGHIJK represent sequences derived from a protein, or Schematic presentation of a tail-to-tail complete matrix scan. In this case the cysteine residue is positioned at the N-terminus of the second building block, leading to a reversed or tail-to-tail orientation of both building blocks. Both sequences are linked as described previously. In this scan both sequences are shifted independently through the complete protein sequence, generating a library of all possible sequence combinations. B) List of all overlapping 12-mer peptides (derived from hFSH) containing an N-terminal bromoacetamide group. C) List of all overlapping 11-mer peptides (derived from hFSH) with an additional C- or N-terminal cysteine. D) Complete matrix scan, i.e. after coupling of ALL listed in FIG. 6B sequences to ALL listed in FIG. 6C sequences, exemplified by cards 145-155 and a full picture of all binding values of all ca. 40.000 peptides (below). The best binding peptide is shown.  
         [0056]    [0056]FIG. 7. A) Schematic presentation of a multi-building block scan. 12345678901 (building block 1), NOPQRSTUVWXY (building block 2) and BCDEFGHIJKLM (building block 3) represent successive sequences derived from a protein. Building blocks were linked via a thioether bridge, formed by reaction of a free thiol function of a C-terminal cysteine residue (C) in building block 1 and a bromoacetamide group ($) at the N-terminus of building block 2 and so on, as described in example 3. In this scan all sequences are subsequently shifted simultanuously through the complete protein sequence to obtain the complete library. B) Working example of obtained wityh anti-hFSH monoclonal antibody-02. C) Binding values and list of peptides coupled onto each other. D)One square in full detail. The peptide br-CKELVYETVRVPG was coupled to the cysteine of card 06. To this card peptides 1 to 36 were spotted with gridding pins. The binding values are shown below.  
         [0057]    Chemistry in short: Polypropylene (PP) surface was gamma irradiated (in this case 50 kGy) in the presence of CuSO4 and in this case 12% acrylic acid. Carboxylic acid functionalized PP was treated with Boc-HMDA/DCC/HOBt and subsequent treatment with trifluoracetic acid (TFA) yielded a surface with amino groups. To this amino group functionalized PP surface, N-Fmoc-S-trityl-L-cysteine (Fmoc-Cys-(Trt)-OH) was coupled using DCC and HOBt. Subsequently the Fmoc group was removed, followed by acetylation of aminogroup. Treatment of the surface with TFA (with triethylsilan and water as scavengers) yielded a thiol functionalized surface. Bromoacetyl (or other thiol reactive) containing peptides were allowed to react with the thiol groups of the PPsurface in 0.015M NaHCO3 (pH 7-8, overnight reaction). Subsequently the -StBu groups (of the S-t-butylthio protected Cys residues) of the coupled peptides were removed using NaBH4 (14 mg/ml in 0.015M NaHCO3 pH 7-8, 30 min, 30° C.), generating new thiol groups in the peptides. A second set of Bromoacetyl (or other thiol reactive) containing peptides were then allowed to couple to the first set, making peptide constructs. This proces can be repeated several times using different sets of bromoacetylated peptides.  
         [0058]    [0058]FIG. 8. A) Schematic presentation of a scan of interacting proteins 1, 2 and 3.  
         [0059]    ABCDEFGHIJK and ABCDEFGHIJK represent two independent sequences from two different proteins combined in one construct. I: a matrix scan of these building blocks was tested against a complete, labeled third protein. II: a matrix scan of building blocks from HIV proteins and the CCR5 protein was tested against a labeled soluble CD4 protein. B) Working example in minicards with parts of hormones and/or receptor. Shown is an example with biotinylated hFSH derived peptides on all overlapping 30-mers covering the hFSH-receptor.  
         [0060]    [0060]FIG. 9. A) Schematic presentation of a matrix combi-scan with a complete protein. The constructs are scanned with a another labeled protein in solution. B) Working example with whole protein glucose oxidase coupled to cysteine on surface. The protein was detected with an anti-glucose oxidase monoclonal antibody. The diameter of the gridding pins used is also shown.  
         [0061]    [0061]FIG. 10. A) Schematic presentation of a DNA/RNA scan. The constructs are scanned with a labeled protein, for example a regulatory protein, or another DNA or PNA strand (top), or alternatively overlapping peptides are scanned with biotynilated RNA, DNA or PNA (bottom). B) Working example with biotinylated DNA on construct of two PNA&#39;s.  
         [0062]    Chemistry in short: Detection of the binding of Biotinylated DNA by the construct of two PNAs. In miniwell setup the polypropylene (PP) surface of the miniwells was functionalized with carboxyl groups using gamma irradiation (12 kGy) in the presence of CuSO4 and 6% acrylic acid. Subsequently the PP surface was amino group functionalized (using BocHMDA/DCC/HOBt with subsequent removal of the Boc group with TFA). Next the amino groups were converted in thiol groups by coupling of Fmoc-Cys-(Trt) using DCC/HOBt, removal of the Fmoc group, acetylation of the amino group followed by removal of the Trt by TFA/triethyl silan. To this PP surface functionalized with thiol groups a PNA (PNA1) was coupled which contains N-terminal a bromoacetyl group and C-terminal an extra Cys-S-tBu (the Bromo group of the PNA reacts to the thiol group of the surface). After removal of the S-tBu (using NaBH4) of the Cys-S-tBu, the couped PNA has a thiol group on C-terminal end. A second PNA (PNA2) containing a Bromoacetyl group N-terminal is coupled to the first PNA (bromogroup of PNA2 react to thiol group of PNA1. PNA1=Br GAGGCCTGCT-Cys-S-tBu, PNA2=Br-ATGGCACTTC. In this way on the PP surface the construct GAGGCCTGCTspacer ATGGCACTTC is made. The spacer between PNA1 and PNA2 has approximately the length of one PNA-nucleotide. FIG. 10B shows the binding of a biotinylated DNA (3′-TATTCTCCGGACGAGTACCGTGAAGGGTC-Biotin-5′) to the PNA construct. Bound Biotinyled-DNA was detected using Streptavidin conjugated to horse radish peroxidase and ABTS. C and D) Working example of scan with biotinylated PNA on overlapping peptides illustrated by a list of peptides derived from a zinc-finger. Polypropylene surface was gamma irradiated (50 kGy) in the presence of 12% acrylic acid. Zinc-finger matrix was tested for the binding with Dna: The Zinc-finger matrix was incubated (in the presence of 0.1 mg/ml herringsperm DNA) overnight with 5′Biotin-AGCGTGGGCGT-3′ hybridised to 3-′Biotin-CGCACCCGCAT-5′ (5 μg/ml). After rinsing the matrix was treated with Streptavidin conjugated to alkalin-phosphatase (in the presence of 1% Bovine Serum Albumin). Rinsing and a subsequent treatment of the matrix with Vistra ECF (as described) visualized the binding between Dna and the peptide constructs of the Zinc-finger. Binding of with 5′Biotin-AGCGTGGGCGT-3′ to peptides zinc-finger. (B, 4-aminobutyric acid, is a replacement for cysteine residue). E) Working example of scan with biotinylated PNA on overlapping peptides illustrated by a list of peptides derived from a zinc-finger. Polypropylene surface was gamma irradiated (12 kGy) in the presence of 6% acrylic acid. Zinc-finger matrix was tested for the binding with Dna: The Zinc-finger matrix was incubated (in the presence of 0.1 mg/ml herringsperm DNA) overnight with 5′Biotin-AGCGTGGGCGT-3′ hybridised to 3-′Biotin-CGCACCCGCAT-5′ (20 ug/ml). After rinsing the matrix was treated with Streptavidin conjugated to alkalin-phosphatase (in the presence of 1% Bovine Serum Albumin). Rinsing and a subsequent treatment of the matrix with Vistra ECF (as described) visualized the binding between Dna and the peptide constructs of the Zinc-finger. Binding of with 5′Biotin-AGCGTGGGCGT-3′ to peptides zinc-finger. (B, 4-aminobutyric acid, is a replacement for cysteine residue).  
         [0063]    [0063]FIG. 11. Illustration of coupling bromoacetamide and cysteine in solution. Graphs shows Mass analysis of peptides before and after coupling showing that both peptides were linked into one longer peptide: A solution of 1 mg/ml (in 0.03M NaHCO3) of a Brombgroup containing peptide BrADSLYTYPVATQamide was added to a 1 mg/ml (in H2O) solution of a thiol containing peptide AcetylVYETVRVPGCamide. The reacting was monitored using Ellmansreagent (determines free thiolgroups). The reaction was complete within 2.5 hours. HPLC analasis reveal the product AcetylVYETVRVPGCamide-(thioether)-ADSLYTYPVATQamide as determined with MS-Quattro.  
         [0064]    [0064]FIG. 12. Schematic presentation of a intracellular protein scan.  
     
    
     DETAILED DESCRIPTION  
       [0065]    Synthesis of Peptide Constructs  
         [0066]    A peptide with a N-terminal bromoacetamide group was synthesised at the surface of a solid support containing free amino groups. The peptide still contained the side-chain protecting groups of the amino acid residues. A second peptide containing a cysteine residue, which was deprotected and cleaved from another solid support was reacted with the bromoacetamide peptide on the first solid support. The formed construct was deprotected, but not cleaved from the support, and could be used in ELISA.  
         [0067]    A polypropylene or polyethylene support, or of other suitable material, was grafted 15 with, for instance, polyacrylic acid. As an example: a polypropylene support in a 6% acrylic acid solution in water, containing CuSO 4 , was irradiated using gamma radiation at a dose of 12 kGy. The grafted solid support containing carboxylic acid groups was functionalised with amino groups via coupling of t-butyloxycarbonyl-hexamethylenediamine (Boc-HMDA) using dicyclohexylcarbodiimide (D CC) with N-hydroxybenzotriazole (HOBt) and subsequent cleavage of the Boc groups using trifluoroacetic acid.  
         [0068]    Standard Fmoc peptide synthesis was used to synthesise peptides on the amino functionalised solid support. After cleavage of the Fmoc group of the last amino acid and washing, bromoacetic acid was coupled using DCC or DCCIHOBt. If only DCC was used the peptide did contain a thiol reactive bromoacetamide group, however, if DCC/HOBt was used to couple bromoacetic acid, the peptide essentially did not contain the bromo group, but another reactive group capable to react efficiently with thiol groups thus forming the same thioether link between the segments.  
         [0069]    Coupling/ligation of a second peptide to a pep tide synthesised on a solid support: Peptides were synthesised at polyethylene pins grafted with poly-hydromethylmethacrylate (poly-HEMA). This graft polymer was made by gamma irradiation of polyethylene pins in a 20% HEMA solution in methanol/water 80/20 or 70/30 at a dose of 30-50 kGy. The functionalised support can be used for the synthesis of 1 μmol of peptide/cm 2  after coupling of β-alanine and an acid labile Fmoc-2,4-dimethoxy-4′-(carboxymethyloxy)-benzhydrylamine (Rink) linker. The peptides were synthesised using standard Fmoc chemistry and the peptide was deprotected and cleaved from the resin using trifluoroacetic acid with scavengers.  
         [0070]    The cleaved peptide containing a cysteine residue at a concentration of about 1 mg/ml was reacted with the solid support bound peptide described above in a water/sodium bicarbonate buffer at about pH 7-8, thus forming a partially protected construct of two peptides covalently bound via a thioether and C-terminally bound to the solid support.  
         [0071]    The construct described above was deprotected following standard procedures using trifluoroacetic acid/scavenger combinations. The deprotected constructs on the solid support were extensively washed using disrupting buffers, containing sodium dodecylsulphate and P-mercaptoethanol, and ultrasonic cleaning and were used directly in ELISA. Subsequent cleaning in the disrupt buffers allows repeatingly testing against other antibodies in ELISA.  
         [0072]    [0072]FIG. 1 shows an example of the ELISA results of screening a simple library of constructs, consisting of a dodecapeptide segment coupled via its C-terminally added cysteine residue to a N-terminally bromoacetylated second segment, scanning a protein sequence by steps of a single amino acid residue. The bromoacetamide peptide was covalently bound to a functionalised polypropylene/polyacrylic acid solid support in 3 μl wells as described above. The cysteine-containing sequences were synthesised on and cleaved from functionalised polyethylene pins as described above. As shown in FIG. 1, high binding was observed in ELISA for constructs around position 125, which consists of the segments [125-136] and [139-150], linked via a the ether bond. A conventional linear PEPSCAN of dodecapeptides or 15-peptides did not show any binding in a reaction against the same monoclonal antibody.  
         [0073]    On a surface of a solid support peptides are synthesized with a bromoacetamide group at the N-terminus as described above. On this peptide functionalized support a second peptide segment containing a free thiol group was spotted using piezo drop-on-demand technology, using a microdosing apparatus and piezo autopipette (Auto Drop-Micropipette AD-K-501) (Microdrop Gesellschaft fur Mikrodosier Systeme GmbH. Alternatively, spotting or gridding was done using miniature solenoid valves (INKX 0502600A; the Ice Company) or hardened precision ground gridding pins (Genomic Solutions, diameters 0.4, 0.6, 0.8 or 1.5 mm). Subsequent deprotection of the construct and extensive washing to remove uncoupled peptide gave dipeptide constructs at the spotted area.  
         [0074]    [0074]FIG. 2 shows binding of the same antibody as was tested in FIG. 1 with constructs consisting of two peptide segments, generated with different volumes of spotted peptides 2 to 8, ranging from 1 μl-0.25 nl (x-axis). Within the square the whole surface was covered with peptide 1, which was synthesised directly on this surface, only the spots contain constructs. The y-axis shows different constructs, consisting of peptide 1 with peptide 2 up to 8. Peptides 2 up to 8 are overlapping dodecapeptides, while peptide 1 is sequence [139-150] of the same protein as described in FIG. 1. FIG. 2 shows that peptide constructs generated with peptide solution droplets in the nanoliter-range, bind enough antibody for detection, in this case using indirect fluorescence detection. Spots generated with 0.25 nl -50 nl are smaller than 1 mm 2 . Thus, peptide construct density can be as large as 100-1000 spots per cm 2 .  
       EXAMPLES OF USE  
       [0075]    Proteins and peptides can be screened using for instance antibodies, soluble receptors, which contain a Fc-tail or a tag for detection, biotinylated molecules or fluorescent molecules. Alternative building blocks could be, for instance, carbohydrates, non-natural amino acids, PNA&#39;s, DNA&#39;s, lipids, molecules containing peptide bond mimetics. In the examples $ is used as a symbol for the thioether link formed by reaction of the thiol group of a cysteine residue of one building block with a bromoacetamide at the N-terminus or at the side chain of a lysine residue from another building block. This symbol can also be used for other linking chemistries as described.  
         [0076]    The examples are divided into two types. Type I is performed in the creditcard format minicards (cf FIG. 1). Type II is performed using gridding pins on a discontinuous porous matrix surface (cf. FIG. 2). For each example the type is indicated between brackets.  
       Example-1  
       [0077]    (Type I): ‘Standard’ 24-30-Mer Scan of Linear Sequence, Containing Two Building Blocks.  
         [0078]    In this example the consecutive sequences of the building blocks are both shifted one by one residue through the sequence of the protein to be tested as shown in FIG. 3A and exemplified in FIGS. 3B and 3C for 30-mers (in FIG. 1 the example is with 24-mers). The -C$-link between both building blocks replaces 0-2 or more amino acid residues of the native protein sequence. Applications include replacement sets of peptides, in which amino acid residues are replaced systematically by other amino acid residues (FIG. 1C), deletion sets of peptides, in which amino acid residues are deleted systematically, and combination sets, in which peptides of different lenght ranging from 2-24 (here building block 2, 2-40 or more and building block 1, 2-15 or more) amino acid residues are used.  
       Example-2a  
       [0079]    (Type I): Positional Scan with Cysteine at Different Positions.  
         [0080]    This is a scan similar to example 1 described above, however, in this scan the cysteine is used to substitute the amino acid residues one by one in every position of the second building block as shown in FIG. 4A and exemplified in FIGS. 4B and 4C. FIG. 5 illustrates the reproducibility of coupling a 25-mer that binds mAb-01 to all overlapping 15-mers.  
       Example-2b  
       [0081]    (Type II): Head-to-Tail Matrix-Scan.  
         [0082]    In type-I, i.e. using the creditcard sized minicards only a few thousand peptides can be synthesized. In type-II, i.e. using the gridding pins, many thousands of peptides (in the order of 40.000) can be synthesized simultaneously.  
         [0083]    In a complete matrix-scan the N-terminal sequence of, for instance, sequence [1-11] of a protein, is linked as a building block with each overlapping peptide sequence of a complete scan of the same protein as shown in FIG. 6A. Next, sequence [2-12] is linked with the same set of overlapping sequences and so on. The link can be formed, for instance, by reaction of a cysteine at the C-terminus of the second building block with a bromoacetamide modified N-terminus of the first building block. This means that every combination of, for instance, undecapeptides from the protein sequence is being synthesised on a seperate, known, position of the solid support.  
         [0084]    Example-2c  
         [0085]    (Type II). Tail-to-Tail Matrix-Scan.  
         [0086]    This is the same scan as the complete matrix scan from example 2a, however, in this scan the cysteine of the second building block is located at its N-terminus, providing a reversed or tail-to-tail orientation of both building blocks in the construct as also shown in FIG. 6A.  
         [0087]    Both example 2b and 2c are illustrated in FIGS. 6B, 6C and  6 D.  
       Example-3  
       [0088]    (Type-II): Multi Building Block Scan.  
         [0089]    In this example a thiol fuction is introduced on an amino-functionalised solid support.  
         [0090]    This can be made by a direct reaction of the amino groups with, for instance, iminothiolane, or by coupling of Fmoc-Cys(Trt)-OH, followed by Fmoc cleavage using piperidine, acetylation, and trityl deprotection using TFA/scavenger mixtures. This thiol-functionalised solid support can be reacted with, for instance, a bromoacetamide-peptide, containing a protected cysteine residue. After coupling of the first peptide, the cysteine can be deprotected, using, for instance, a TFA/scavenger mixture. The formed free thiol group can be used to couple a second bromoacetamide-peptide, again containing a protected cysteine. This procedure can be repeated to make multi-building block constructs. Several types of scans, as described in the other examples, can be used in combination with this multi building, block scan. In FIG. 7A an example is shown for a three multi building block scan. An working example with two building block scan is illustrated in  7 B,  7 C and  7 D.  
       Example-4  
       [0091]    (Type-I): Matrix Combi-Scan, Interaction Between Three (or More) Proteins  
         [0092]    In a matrix combi-scan, a matrix scan from two different proteins is tested against a labeled soluble protein. FIG. 8A shows two examples. In the first example (FIG. 8A) soluble protein 1 (growth hormone, GH) was tested against a combined matrix scan of protein 2 (GH-receptor-1) and protein-3 (GH-receptor-2). In the second example a part of soluble protein 1 (CD-4) was tested against a combined matrix scan of protein 2 (HIV) and protein 3 (chemokine-receptor CCR4). In FIG. 8B the usage of receptors and hormones is illustrated by using a biotin-labeled part of the protein human  
         [0093]    Follicle Stimulating Hormone tested on all overlapping 30-mers covering te human human Follicle Stimulating Hormone receptor.  
         [0094]    Examples 1 to 4 describe methods using peptide building blocks and screening with proteins. These constructs can also be screened against non-proteins. Also non-peptide building blocks can be used. Below, examples of whole proteins in combination with peptides (example 5), or peptides/proteins in combination with non-peptide/proteins, or non-peptide/protein with non-peptide/protein (example 6, DNA/RNA/PNA) are shown.  
       Example-5  
       [0095]    (Type II): Matrix Combi-Scan, Interaction Between Three (or More) Proteins  
         [0096]    This example is similar to example 4. The difference is that the building block 2 sequences, derived from one protein (ABCDEFGHIJKC etc.) are replaced by a complete protein, which contains an added thiol group for coupling (see FIG. 9A). To illustrate that native proteins can be used to be coupled in this way the protein glucose oxidase was used as an example (FIG. 9B).  
       Example-6  
       [0097]    (Type I and Type-II): Scans of Linear DNA/PNA/Peptide With DNA/PNA/Peptide  
         [0098]    This example is similar to that of examples 1 to 5 with the difference that one or more other non-peptide building blocks are used (DNA, RNA or a peptide nucleic acid (PNA) instead of a peptide building block). The nucleotide building blocks or PNA&#39;s are modified with groups that enable linking of the building blocks as in examples 1 to 5. Screening is performed with labeled DNA strands, peptides or proteins (see FIG. 10). As alternative labeled DNA or PNA strands can also be tested against peptide construct described in examples 1 to 5. The binding binding between peptide and PNA is illustrated in FIGS. 10B and 10C,  10 D.  
         [0099]    In addition to scanning interaction regions of proteins and non-proteins (DNA/RNA) in ELISA, chip or or blot format it is also possible to use to -C$-coupling in in vitro bio-assays. Firstly, it is possible to use soluble constructs as explained in example-3 as potential (ant)agonists for membrane bound receptors. Secondly, it is possible to use membrane-transporting proteins such as transportan or penetratin to get any of the above mentioned combinations of peptides or peptides with PNA or peptides with (small) proteins into the cell.  
         [0100]    In FIG. 11 it is illustrated that it is possible to couple two peptides in solution. In this example peptides similar to these shown in for example FIGS. 1A, 1B,  2 B and  3 B.  
       Example-7a  
       [0101]    (Type I): Intracellular Protein Scan Coupled to Membrane-Penetrating Transportan.  
         [0102]    An intracellular protein, like a kinase, can be scanned using overlapping peptides on a solid support, containing a C-terminal cleavable linker. The peptides were synthesised with a N-terminal bromoacetamide group. Next, a membrane penetrating transportan peptide, containing a label and a thiol group was coupled with the sequences. These constructs were selectively cleaved from the solid support and tested in a bioassay. Labels that can be used are, for instance, biotine or fluorescent labels (FIG. 12).  
       Example-7b  
       [0103]    (Type I): Intracellular RNA, DNA or PNA-Scan Coupled to Membrane-Penetrating Transportan.  
         [0104]    To identify PNA/DNA sequences that can be used to block expression of a particular gene a long linear scan, coupled to membrane penetrating peptide, can be tested in an in vitro bio-assay (FIG. 12).  
     
       
       
         1 
         
           
             660  
           
           
             1  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
                         derived peptide  
             
           
            1 

Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
  1               5                  10 

 
           
             2  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
                         derived peptide  
             
           
            2 

Cys Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly 
  1               5                  10 

 
           
             3  
             29  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      biotinylated DNA  
             
           
            3 

tattctccgg acgagtaccg tgaagggtc                                       29 

 
           
             4  
             11  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      biotinylated DNA  
             
           
            4 

agcgtgggcg t                                                          11 

 
           
             5  
             11  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      biotinylated DNA  
             
           
            5 

cgcacccgca t                                                          11 

 
           
             6  
             10  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      thiol containing peptide  
             
           
            6 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
  1               5                  10 

 
           
             7  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence identified 
      epitope of hFSH, containing a thioether linkage 
      within the sequence  
             
           
            7 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala Cys Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             8  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 2 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            8 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Cys Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             9  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 3 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            9 

Cys Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             10  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 4 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            10 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             11  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 5 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            11 

Cys Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             12  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 7 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            12 

Cys Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             13  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 8 - 
      peptide 1 derived from hFSH, containing a 
      thioether linkage within the sequence  
             
           
            13 

Glu Thr Val Arg Val Pro Gly Cys Ala His His Cys Ala Asp Ser Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln 
             20 

 
           
             14  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            14 

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Cys Cys 
  1               5                  10                  15 

Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr 
             20                  25                  30 

 
           
             15  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            15 

Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Phe 
  1               5                  10                  15 

Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr 
             20                  25                  30 

 
           
             16  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            16 

Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Cys Ile 
  1               5                  10                  15 

Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg 
             20                  25                  30 

 
           
             17  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            17 

Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Cys Ile 
  1               5                  10                  15 

Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu 
             20                  25                  30 

 
           
             18  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            18 

Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Cys Thr 
  1               5                  10                  15 

Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr 
             20                  25                  30 

 
           
             19  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            19 

Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Cys Trp 
  1               5                  10                  15 

Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
             20                  25                  30 

 
           
             20  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            20 

Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Cys Ala 
  1               5                  10                  15 

Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
             20                  25                  30 

 
           
             21  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            21 

Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Cys Tyr 
  1               5                  10                  15 

Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
             20                  25                  30 

 
           
             22  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            22 

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Cys Tyr 
  1               5                  10                  15 

Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile 
             20                  25                  30 

 
           
             23  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            23 

Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Cys Arg 
  1               5                  10                  15 

Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
             20                  25                  30 

 
           
             24  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            24 

Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Cys Leu 
  1               5                  10                  15 

Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
             20                  25                  30 

 
           
             25  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            25 

Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Cys Tyr 
  1               5                  10                  15 

Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe 
             20                  25                  30 

 
           
             26  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            26 

Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Cys Asp 
  1               5                  10                  15 

Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu 
             20                  25                  30 

 
           
             27  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            27 

Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Cys Ala 
  1               5                  10                  15 

Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val 
             20                  25                  30 

 
           
             28  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            28 

Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Cys Pro 
  1               5                  10                  15 

Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu 
             20                  25                  30 

 
           
             29  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            29 

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Cys Ile 
  1               5                  10                  15 

Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val 
             20                  25                  30 

 
           
             30  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            30 

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Cys Lys 
  1               5                  10                  15 

Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
             20                  25                  30 

 
           
             31  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            31 

Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Cys Cys 
  1               5                  10                  15 

Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly 
             20                  25                  30 

 
           
             32  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            32 

Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Phe 
  1               5                  10                  15 

Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala 
             20                  25                  30 

 
           
             33  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            33 

Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Cys Glu 
  1               5                  10                  15 

Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His 
             20                  25                  30 

 
           
             34  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            34 

Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Cys Val 
  1               5                  10                  15 

Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His Ala Asp 
             20                  25                  30 

 
           
             35  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            35 

Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Cys Glu 
  1               5                  10                  15 

Thr Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser Leu 
             20                  25                  30 

 
           
             36  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            36 

Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Cys Val 
  1               5                  10                  15 

Arg Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr 
             20                  25                  30 

 
           
             37  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            37 

Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Cys Val 
        1               5                10                  15 
Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro 
             20                  25                  30 

 
           
             38  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            38 

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Cys Gly 
  1               5                  10                  15 

Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala 
             20                  25                  30 

 
           
             39  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            39 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Cys Ala 
  1               5                  10                  15 

His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
             20                  25                  30 

 
           
             40  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            40 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Cys His 
  1               5                  10                  15 

Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His 
             20                  25                  30 

 
           
             41  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            41 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His Cys Asp 
  1               5                  10                  15 

Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly 
             20                  25                  30 

 
           
             42  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            42 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His Ala Cys Leu 
  1               5                  10                  15 

Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys 
             20                  25                  30 

 
           
             43  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            43 

Glu Thr Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser Cys Thr 
  1               5                  10                  15 

Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser 
             20                  25                  30 

 
           
             44  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            44 

Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Cys Pro 
  1               5                  10                  15 

Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser 
             20                  25                  30 

 
           
             45  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            45 

Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Cys Ala 
  1               5                  10                  15 

Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp 
             20                  25                  30 

 
           
             46  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            46 

Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Cys Gln 
  1               5                  10                  15 

Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr 
             20                  25                  30 

 
           
             47  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            47 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Cys His 
  1               5                  10                  15 

Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg 
             20                  25                  30 

 
           
             48  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            48 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys Cys Gly 
  1               5                  10                  15 

Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu 
             20                  25                  30 

 
           
             49  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            49 

Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Cys Cys 
  1               5                  10                  15 

Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro 
             20                  25                  30 

 
           
             50  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            50 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Ser 
  1               5                  10                  15 

Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr 
             20                  25                  30 

 
           
             51  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            51 

Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Cys Ser 
  1               5                  10                  15 

Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser 
             20                  25                  30 

 
           
             52  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            52 

Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Cys Asp 
  1               5                  10                  15 

Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly 
             20                  25                  30 

 
           
             53  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            53 

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Cys Thr 
  1               5                  10                  15 

Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met 
             20                  25                  30 

 
           
             54  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence h FSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            54 

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Cys Arg 
  1               5                  10                  15 

Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
             20                  25                  30 

 
           
             55  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence identified 
      epitope of hFSH, containing a thioether linkage 
      within the sequence  
             
           
            55 

Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys His 
  1               5                  10                  15 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys 
             20                  25                  30 

 
           
             56  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            56 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Asn Ser Cys Glu 
  1               5                  10                  15 

Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu 
             20                  25 

 
           
             57  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            57 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Cys Glu Leu Thr 
  1               5                  10                  15 

Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys 
             20                  25 

 
           
             58  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            58 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Leu Thr Asn Ile 
  1               5                  10                  15 

Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe 
             20                  25 

 
           
             59  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            59 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Asn Ile Thr Ile 
  1               5                  10                  15 

Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile 
             20                  25 

 
           
             60  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            60 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Thr Ile Ala Ile 
  1               5                  10                  15 

Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile 
             20                  25 

 
           
             61  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            61 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ala Ile Glu Lys 
  1               5                  10                  15 

Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr 
             20                  25 

 
           
             62  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            62 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Glu Lys Glu Glu 
  1               5                  10                  15 

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp 
             20                  25 

 
           
             63  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            63 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Glu Glu Cys Arg 
  1               5                  10                  15 

Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala 
             20                  25 

 
           
             64  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            64 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Cys Arg Phe Cys 
  1               5                  10                  15 

Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr 
             20                  25 

 
           
             65  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            65 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Phe Cys Ile Ser 
  1               5                  10                  15 

Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr 
             20                  25 

 
           
             66  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            66 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ile Ser Ile Asn 
  1               5                  10                  15 

Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg 
             20                  25 

 
           
             67  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            67 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ile Asn Thr Thr 
  1               5                  10                  15 

Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu 
             20                  25 

 
           
             68  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            68 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Thr Thr Trp Cys 
  1               5                  10                  15 

Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr 
             20                  25 

 
           
             69  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            69 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Trp Cys Ala Gly 
  1               5                  10                  15 

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
             20                  25 

 
           
             70  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            70 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ala Gly Tyr Cys 
  1               5                  10                  15 

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
             20                  25 

 
           
             71  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            71 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Tyr Cys Tyr Thr 
  1               5                  10                  15 

Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
             20                  25 

 
           
             72  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            72 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Tyr Thr Arg Asp 
  1               5                  10                  15 

Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile 
             20                  25 

 
           
             73  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            73 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Arg Asp Leu Val 
  1               5                  10                  15 

Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
             20                  25 

 
           
             74  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            74 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Leu Val Tyr Lys 
  1               5                  10                  15 

Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
             20                  25 

 
           
             75  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            75 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Tyr Lys Asp Pro 
  1               5                  10                  15 

Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe 
             20                  25 

 
           
             76  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            76 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Asp Pro Ala Arg 
  1               5                  10                  15 

Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu 
             20                  25 

 
           
             77  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            77 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ala Arg Pro Lys 
  1               5                  10                  15 

Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val 
             20                  25 

 
           
             78  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            78 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Pro Lys Ile Gln 
  1               5                  10                  15 

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu 
             20                  25 

 
           
             79  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            79 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ile Gln Lys Thr 
  1               5                  10                  15 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val 
             20                  25 

 
           
             80  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            80 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Lys Thr Cys Thr 
  1               5                  10                  15 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
             20                  25 

 
           
             81  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            81 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Cys Thr Phe Lys 
  1               5                  10                  15 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly 
             20                  25 

 
           
             82  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            82 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Phe Lys Glu Leu 
  1               5                  10                  15 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala 
             20                  25 

 
           
             83  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            83 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Glu Leu Val Tyr 
  1               5                  10                  15 

Glu Thr Val Arg Val Pro Gly Cys Ala His His 
             20                  25 

 
           
             84  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            84 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Val Tyr Glu Thr 
  1               5                  10                  15 

Val Arg Val Pro Gly Cys Ala His His Ala Asp 
             20                  25 

 
           
             85  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            85 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Glu Thr Val Arg 
  1               5                  10                  15 

Val Pro Gly Cys Ala His His Ala Asp Ser Leu 
             20                  25 

 
           
             86  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            86 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Val Arg Val Pro 
  1               5                  10                  15 

Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr 
             20                  25 

 
           
             87  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            87 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Val Pro Gly Cys 
  1               5                  10                  15 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro 
             20                  25 

 
           
             88  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            88 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Gly Cys Ala His 
  1               5                  10                  15 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala 
             20                  25 

 
           
             89  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            89 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ala His His Ala 
  1               5                  10                  15 

Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
             20                  25 

 
           
             90  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            90 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile His Ala Asp Ser 
  1               5                  10                  15 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His 
             20                  25 

 
           
             91  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            91 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Asp Ser Leu Tyr 
  1               5                  10                  15 

Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly 
             20                  25 

 
           
             92  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            92 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Leu Tyr Thr Tyr 
  1               5                  10                  15 

Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys 
             20                  25 

 
           
             93  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            93 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Thr Tyr Pro Val 
  1               5                  10                  15 

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser 
             20                  25 

 
           
             94  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            94 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Pro Val Ala Thr 
  1               5                  10                  15 

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser 
             20                  25 

 
           
             95  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            95 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ala Thr Gln Cys 
  1               5                  10                  15 

His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp 
             20                  25 

 
           
             96  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            96 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Gln Cys His Cys 
  1               5                  10                  15 

Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr 
             20                  25 

 
           
             97  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            97 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile His Cys Gly Lys 
  1               5                  10                  15 

Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg 
             20                  25 

 
           
             98  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            98 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Gly Lys Cys Asp 
  1               5                  10                  15 

Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu 
             20                  25 

 
           
             99  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            99 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Cys Asp Ser Asp 
  1               5                  10                  15 

Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro 
             20                  25 

 
           
             100  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            100 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ser Asp Ser Thr 
  1               5                  10                  15 

Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr 
             20                  25 

 
           
             101  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            101 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Ser Thr Asp Cys 
  1               5                  10                  15 

Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser 
             20                  25 

 
           
             102  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            102 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Asp Cys Thr Val 
  1               5                  10                  15 

Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly 
             20                  25 

 
           
             103  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            103 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Thr Val Arg Gly 
  1               5                  10                  15 

Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met 
             20                  25 

 
           
             104  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            104 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Arg Gly Leu Gly 
  1               5                  10                  15 

Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
             20                  25 

 
           
             105  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence identified 
      hFSH epitope, containing a thioether linkage 
      within the sequence  
             
           
            105 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Ala Ile Thr Val Arg Val 
  1               5                  10                  15 

Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr 
             20                  25 

 
           
             106  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            106 

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu 
  1               5                  10                  15 

 
           
             107  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            107 

Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg 
  1               5                  10                  15 

 
           
             108  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            108 

Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile 
  1               5                  10                  15 

 
           
             109  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            109 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn 
  1               5                  10                  15 

 
           
             110  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            110 

Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp 
  1               5                  10                  15 

 
           
             111  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            111 

Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
  1               5                  10                  15 

 
           
             112  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            112 

Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr 
  1               5                  10                  15 

 
           
             113  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            113 

Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp 
  1               5                  10                  15 

 
           
             114  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            114 

Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr 
  1               5                  10                  15 

 
           
             115  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            115 

Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
  1               5                  10                  15 

 
           
             116  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            116 

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
  1               5                  10                  15 

 
           
             117  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            117 

Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
  1               5                  10                  15 

 
           
             118  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            118 

Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
  1               5                  10                  15 

 
           
             119  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            119 

Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys 
  1               5                  10                  15 

 
           
             120  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            120 

Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val 
  1               5                  10                  15 

 
           
             121  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            121 

Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr 
  1               5                  10                  15 

 
           
             122  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            122 

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
  1               5                  10                  15 

 
           
             123  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            123 

Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
  1               5                  10                  15 

 
           
             124  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            124 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His 
  1               5                  10                  15 

 
           
             125  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            125 

Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser 
  1               5                  10                  15 

 
           
             126  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            126 

Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr 
  1               5                  10                  15 

 
           
             127  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            127 

Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
  1               5                  10                  15 

 
           
             128  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            128 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
  1               5                  10                  15 

 
           
             129  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            129 

Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys 
  1               5                  10                  15 

 
           
             130  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            130 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys 
  1               5                  10                  15 

 
           
             131  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            131 

Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp 
  1               5                  10                  15 

 
           
             132  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            132 

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp 
  1               5                  10                  15 

 
           
             133  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            133 

Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val 
  1               5                  10                  15 

 
           
             134  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            134 

Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu 
  1               5                  10                  15 

 
           
             135  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            135 

Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser 
  1               5                  10                  15 

 
           
             136  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            136 

Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser 
  1               5                  10                  15 

 
           
             137  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            137 

Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu 
  1               5                  10                  15 

 
           
             138  
             15  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, coupled to acetyl-VYETVRVPGCAHHADSLYTYPVATQ-conh2  
             
           
            138 

Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
  1               5                  10                  15 

 
           
             139  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            139 

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu 
  1               5                  10 

 
           
             140  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            140 

Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln 
  1               5                  10 

 
           
             141  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            141 

Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu 
  1               5                  10 

 
           
             142  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            142 

Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn 
  1               5                  10 

 
           
             143  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            143 

Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
  1               5                  10 

 
           
             144  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            144 

Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe 
  1               5                  10 

 
           
             145  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            145 

Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe 
  1               5                  10 

 
           
             146  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            146 

Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser 
  1               5                  10 

 
           
             147  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            147 

Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln 
  1               5                  10 

 
           
             148  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            148 

Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro 
  1               5                  10 

 
           
             149  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            149 

Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly 
  1               5                  10 

 
           
             150  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            150 

Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala 
  1               5                  10 

 
           
             151  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            151 

Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
  1               5                  10 

 
           
             152  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            152 

Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile 
  1               5                  10 

 
           
             153  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            153 

Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu 
  1               5                  10 

 
           
             154  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            154 

Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln 
  1               5                  10 

 
           
             155  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            155 

Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys 
  1               5                  10 

 
           
             156  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            156 

Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met 
  1               5                  10 

 
           
             157  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            157 

Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly 
  1               5                  10 

 
           
             158  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            158 

Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys 
  1               5                  10 

 
           
             159  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            159 

Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
  1               5                  10 

 
           
             160  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            160 

Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys Phe 
  1               5                  10 

 
           
             161  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            161 

Ala Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Ser 
  1               5                  10 

 
           
             162  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            162 

Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg 
  1               5                  10 

 
           
             163  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            163 

Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala 
  1               5                  10 

 
           
             164  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            164 

Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
  1               5                  10 

 
           
             165  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            165 

Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
  1               5                  10 

 
           
             166  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            166 

Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
  1               5                  10 

 
           
             167  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            167 

Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
  1               5                  10 

 
           
             168  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            168 

Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu 
  1               5                  10 

 
           
             169  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            169 

Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg 
  1               5                  10 

 
           
             170  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            170 

Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser 
  1               5                  10 

 
           
             171  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            171 

Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys 
  1               5                  10 

 
           
             172  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            172 

Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys 
  1               5                  10 

 
           
             173  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            173 

Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr 
  1               5                  10 

 
           
             174  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            174 

Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met 
  1               5                  10 

 
           
             175  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            175 

Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
  1               5                  10 

 
           
             176  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            176 

Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val 
  1               5                  10 

 
           
             177  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            177 

Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val Gln 
  1               5                  10 

 
           
             178  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            178 

Pro Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys 
  1               5                  10 

 
           
             179  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            179 

Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn 
  1               5                  10 

 
           
             180  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            180 

Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val 
  1               5                  10 

 
           
             181  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            181 

Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr 
  1               5                  10 

 
           
             182  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            182 

Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser 
  1               5                  10 

 
           
             183  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            183 

Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
  1               5                  10 

 
           
             184  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            184 

Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser 
  1               5                  10 

 
           
             185  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            185 

Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr 
  1               5                  10 

 
           
             186  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            186 

Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys 
  1               5                  10 

 
           
             187  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            187 

Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys 
  1               5                  10 

 
           
             188  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            188 

Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val 
  1               5                  10 

 
           
             189  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            189 

Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala 
  1               5                  10 

 
           
             190  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            190 

Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys 
  1               5                  10 

 
           
             191  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            191 

Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
  1               5                  10 

 
           
             192  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            192 

Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr 
  1               5                  10 

 
           
             193  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            193 

Ser Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn 
  1               5                  10 

 
           
             194  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            194 

Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg 
  1               5                  10 

 
           
             195  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            195 

Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val 
  1               5                  10 

 
           
             196  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            196 

Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr 
  1               5                  10 

 
           
             197  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            197 

Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val 
  1               5                  10 

 
           
             198  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            198 

Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met 
  1               5                  10 

 
           
             199  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            199 

Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
  1               5                  10 

 
           
             200  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            200 

Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly 
  1               5                  10 

 
           
             201  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            201 

Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe 
  1               5                  10 

 
           
             202  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            202 

Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys 
  1               5                  10 

 
           
             203  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            203 

Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val 
  1               5                  10 

 
           
             204  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            204 

Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu 
  1               5                  10 

 
           
             205  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            205 

Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn 
  1               5                  10 

 
           
             206  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            206 

Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His 
  1               5                  10 

 
           
             207  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            207 

Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
  1               5                  10 

 
           
             208  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            208 

Val Met Gly Gly Phe Lys Val Glu Asn His Thr Ala 
  1               5                  10 

 
           
             209  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            209 

Met Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys 
  1               5                  10 

 
           
             210  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            210 

Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys His 
  1               5                  10 

 
           
             211  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            211 

Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys 
  1               5                  10 

 
           
             212  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            212 

Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser 
  1               5                  10 

 
           
             213  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            213 

Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr 
  1               5                  10 

 
           
             214  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            214 

Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys 
  1               5                  10 

 
           
             215  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            215 

Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
  1               5                  10 

 
           
             216  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            216 

Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr 
  1               5                  10 

 
           
             217  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            217 

His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His 
  1               5                  10 

 
           
             218  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            218 

Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys 
  1               5                  10 

 
           
             219  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            219 

Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
  1               5                  10 

 
           
             220  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            220 

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile 
  1               5                  10 

 
           
             221  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            221 

Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu 
  1               5                  10 

 
           
             222  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            222 

Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
  1               5                  10 

 
           
             223  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            223 

Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu 
  1               5                  10 

 
           
             224  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            224 

Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu 
  1               5                  10 

 
           
             225  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            225 

Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys 
  1               5                  10 

 
           
             226  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            226 

Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg 
  1               5                  10 

 
           
             227  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            227 

Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe 
  1               5                  10 

 
           
             228  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            228 

Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys 
  1               5                  10 

 
           
             229  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            229 

Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile 
  1               5                  10 

 
           
             230  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            230 

Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser 
  1               5                  10 

 
           
             231  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            231 

Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile 
  1               5                  10 

 
           
             232  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            232 

Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn 
  1               5                  10 

 
           
             233  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            233 

Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr 
  1               5                  10 

 
           
             234  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            234 

Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr 
  1               5                  10 

 
           
             235  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            235 

Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp 
  1               5                  10 

 
           
             236  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            236 

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys 
  1               5                  10 

 
           
             237  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            237 

Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala 
  1               5                  10 

 
           
             238  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            238 

Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
  1               5                  10 

 
           
             239  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            239 

Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr 
  1               5                  10 

 
           
             240  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            240 

Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys 
  1               5                  10 

 
           
             241  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            241 

Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr 
  1               5                  10 

 
           
             242  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            242 

Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr 
  1               5                  10 

 
           
             243  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            243 

Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg 
  1               5                  10 

 
           
             244  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            244 

Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp 
  1               5                  10 

 
           
             245  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            245 

Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu 
  1               5                  10 

 
           
             246  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            246 

Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val 
  1               5                  10 

 
           
             247  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            247 

Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr 
  1               5                  10 

 
           
             248  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            248 

Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys 
  1               5                  10 

 
           
             249  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            249 

Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
  1               5                  10 

 
           
             250  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            250 

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
  1               5                  10 

 
           
             251  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            251 

Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
  1               5                  10 

 
           
             252  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            252 

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg 
  1               5                  10 

 
           
             253  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            253 

Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
  1               5                  10 

 
           
             254  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            254 

Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
  1               5                  10 

 
           
             255  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            255 

Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile 
  1               5                  10 

 
           
             256  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            256 

Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
  1               5                  10 

 
           
             257  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            257 

Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
  1               5                  10 

 
           
             258  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            258 

Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr 
  1               5                  10 

 
           
             259  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            259 

Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
  1               5                  10 

 
           
             260  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            260 

Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr 
  1               5                  10 

 
           
             261  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            261 

Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe 
  1               5                  10 

 
           
             262  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            262 

Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys 
  1               5                  10 

 
           
             263  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            263 

Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu 
  1               5                  10 

 
           
             264  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            264 

Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu 
  1               5                  10 

 
           
             265  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            265 

Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val 
  1               5                  10 

 
           
             266  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            266 

Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr 
  1               5                  10 

 
           
             267  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            267 

Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu 
  1               5                  10 

 
           
             268  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            268 

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr 
  1               5                  10 

 
           
             269  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            269 

Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val 
  1               5                  10 

 
           
             270  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            270 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
  1               5                  10 

 
           
             271  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            271 

Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
  1               5                  10 

 
           
             272  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            272 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro 
  1               5                  10 

 
           
             273  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            273 

Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly 
  1               5                  10 

 
           
             274  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            274 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
  1               5                  10 

 
           
             275  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            275 

Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala 
  1               5                  10 

 
           
             276  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            276 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His 
  1               5                  10 

 
           
             277  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            277 

Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His His 
  1               5                  10 

 
           
             278  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            278 

Glu Thr Val Arg Val Pro Gly Cys Ala His His Ala 
  1               5                  10 

 
           
             279  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            279 

Thr Val Arg Val Pro Gly Cys Ala His His Ala Asp 
  1               5                  10 

 
           
             280  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            280 

Val Arg Val Pro Gly Cys Ala His His Ala Asp Ser 
  1               5                  10 

 
           
             281  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            281 

Arg Val Pro Gly Cys Ala His His Ala Asp Ser Leu 
  1               5                  10 

 
           
             282  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            282 

Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr 
  1               5                  10 

 
           
             283  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            283 

Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr 
  1               5                  10 

 
           
             284  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            284 

Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr 
  1               5                  10 

 
           
             285  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            285 

Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro 
  1               5                  10 

 
           
             286  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            286 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
  1               5                  10 

 
           
             287  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            287 

His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala 
  1               5                  10 

 
           
             288  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            288 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr 
  1               5                  10 

 
           
             289  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            289 

Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
  1               5                  10 

 
           
             290  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            290 

Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys 
  1               5                  10 

 
           
             291  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            291 

Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His 
  1               5                  10 

 
           
             292  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            292 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys 
  1               5                  10 

 
           
             293  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            293 

Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly 
  1               5                  10 

 
           
             294  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            294 

Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys 
  1               5                  10 

 
           
             295  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            295 

Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys 
  1               5                  10 

 
           
             296  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            296 

Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp 
  1               5                  10 

 
           
             297  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            297 

Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser 
  1               5                  10 

 
           
             298  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            298 

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp 
  1               5                  10 

 
           
             299  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            299 

Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser 
  1               5                  10 

 
           
             300  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            300 

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr 
  1               5                  10 

 
           
             301  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            301 

Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp 
  1               5                  10 

 
           
             302  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            302 

His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
  1               5                  10 

 
           
             303  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            303 

Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr 
  1               5                  10 

 
           
             304  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            304 

Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val 
  1               5                  10 

 
           
             305  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            305 

Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg 
  1               5                  10 

 
           
             306  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            306 

Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly 
  1               5                  10 

 
           
             307  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            307 

Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu 
  1               5                  10 

 
           
             308  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            308 

Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly 
  1               5                  10 

 
           
             309  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            309 

Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro 
  1               5                  10 

 
           
             310  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            310 

Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser 
  1               5                  10 

 
           
             311  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            311 

Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr 
  1               5                  10 

 
           
             312  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            312 

Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys 
  1               5                  10 

 
           
             313  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            313 

Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser 
  1               5                  10 

 
           
             314  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            314 

Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe 
  1               5                  10 

 
           
             315  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            315 

Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly 
  1               5                  10 

 
           
             316  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            316 

Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu 
  1               5                  10 

 
           
             317  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            317 

Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met 
  1               5                  10 

 
           
             318  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            318 

Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
  1               5                  10 

 
           
             319  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 12-mer 
      peptide derived from hFSH  
             
           
            319 

Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
  1               5                  10 

 
           
             320  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            320 

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Cys 
  1               5                  10 

 
           
             321  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            321 

Cys Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu 
  1               5                  10 

 
           
             322  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            322 

Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Cys 
  1               5                  10 

 
           
             323  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            323 

Cys Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu 
  1               5                  10 

 
           
             324  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            324 

Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Cys 
  1               5                  10 

 
           
             325  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            325 

Cys Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
  1               5                  10 

 
           
             326  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            326 

Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Cys 
  1               5                  10 

 
           
             327  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            327 

Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe 
  1               5                  10 

 
           
             328  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            328 

Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Cys 
  1               5                  10 

 
           
             329  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            329 

Cys Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln 
  1               5                  10 

 
           
             330  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            330 

Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Cys 
  1               5                  10 

 
           
             331  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            331 

Cys Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly 
  1               5                  10 

 
           
             332  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            332 

Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Cys 
  1               5                  10 

 
           
             333  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            333 

Cys Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
  1               5                  10 

 
           
             334  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            334 

Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Cys 
  1               5                  10 

 
           
             335  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            335 

Cys Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu 
  1               5                  10 

 
           
             336  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            336 

Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys 
  1               5                  10 

 
           
             337  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            337 

Cys Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys 
  1               5                  10 

 
           
             338  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            338 

Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Cys 
  1               5                  10 

 
           
             339  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            339 

Cys Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly 
  1               5                  10 

 
           
             340  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            340 

Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
  1               5                  10 

 
           
             341  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            341 

Cys Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
  1               5                  10 

 
           
             342  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            342 

Ala Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Cys 
  1               5                  10 

 
           
             343  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            343 

Cys Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Ser 
  1               5                  10 

 
           
             344  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            344 

Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Cys 
  1               5                  10 

 
           
             345  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            345 

Cys Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala 
  1               5                  10 

 
           
             346  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            346 

Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Cys 
  1               5                  10 

 
           
             347  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            347 

Cys Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
  1               5                  10 

 
           
             348  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            348 

Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Cys 
  1               5                  10 

 
           
             349  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            349 

Cys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
  1               5                  10 

 
           
             350  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            350 

Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Cys 
  1               5                  10 

 
           
             351  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            351 

Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg 
  1               5                  10 

 
           
             352  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            352 

Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Cys 
  1               5                  10 

 
           
             353  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            353 

Cys Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys 
  1               5                  10 

 
           
             354  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            354 

Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Cys 
  1               5                  10 

 
           
             355  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            355 

Cys Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr 
  1               5                  10 

 
           
             356  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            356 

Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Cys 
  1               5                  10 

 
           
             357  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            357 

Cys Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
  1               5                  10 

 
           
             358  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            358 

Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val Cys 
  1               5                  10 

 
           
             359  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            359 

Cys Pro Leu Arg Ser Lys Lys Thr Met Leu Val Gln 
  1               5                  10 

 
           
             360  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            360 

Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Cys 
  1               5                  10 

 
           
             361  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            361 

Cys Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn 
  1               5                  10 

 
           
             362  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            362 

Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Cys 
  1               5                  10 

 
           
             363  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            363 

Cys Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr 
  1               5                  10 

 
           
             364  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            364 

Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Cys 
  1               5                  10 

 
           
             365  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            365 

Cys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
  1               5                  10 

 
           
             366  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            366 

Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser Cys 
  1               5                  10 

 
           
             367  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            367 

Cys Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr 
  1               5                  10 

 
           
             368  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            368 

Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys 
  1               5                  10 

 
           
             369  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            369 

Cys Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys 
  1               5                  10 

 
           
             370  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            370 

Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Cys 
  1               5                  10 

 
           
             371  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            371 

Cys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala 
  1               5                  10 

 
           
             372  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            372 

Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Cys 
  1               5                  10 

 
           
             373  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            373 

Cys Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
  1               5                  10 

 
           
             374  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            374 

Ser Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Cys 
  1               5                  10 

 
           
             375  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            375 

Cys Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn 
  1               5                  10 

 
           
             376  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            376 

Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Cys 
  1               5                  10 

 
           
             377  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            377 

Cys Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val 
  1               5                  10 

 
           
             378  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            378 

Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Cys 
  1               5                  10 

 
           
             379  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            379 

Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val 
  1               5                  10 

 
           
             380  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            380 

Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Cys 
  1               5                  10 

 
           
             381  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            381 

Cys Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
  1               5                  10 

 
           
             382  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            382 

Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly Cys 
  1               5                  10 

 
           
             383  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            383 

Cys Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe 
  1               5                  10 

 
           
             384  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            384 

Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Cys 
  1               5                  10 

 
           
             385  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            385 

Cys Asn Arg Val Thr Val Met Gly Gly Phe Lys Val 
  1               5                  10 

 
           
             386  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            386 

Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Cys 
  1               5                  10 

 
           
             387  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            387 

Cys Val Thr Val Met Gly Gly Phe Lys Val Glu Asn 
  1               5                  10 

 
           
             388  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            388 

Thr Val Met Gly Gly Phe Lys Val Glu Asn His Cys 
  1               5                  10 

 
           
             389  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            389 

Cys Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
  1               5                  10 

 
           
             390  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            390 

Met Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys 
  1               5                  10 

 
           
             391  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            391 

Cys Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys 
  1               5                  10 

 
           
             392  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            392 

Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys 
  1               5                  10 

 
           
             393  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            393 

Cys Phe Lys Val Glu Asn His Thr Ala Cys His Cys 
  1               5                  10 

 
           
             394  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            394 

Lys Val Glu Asn His Thr Ala Cys His Cys Ser Cys 
  1               5                  10 

 
           
             395  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            395 

Cys Val Glu Asn His Thr Ala Cys His Cys Ser Thr 
  1               5                  10 

 
           
             396  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            396 

Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Cys 
  1               5                  10 

 
           
             397  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            397 

Cys Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
  1               5                  10 

 
           
             398  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            398 

His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr Cys 
  1               5                  10 

 
           
             399  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            399 

Cys Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His 
  1               5                  10 

 
           
             400  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            400 

Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Cys 
  1               5                  10 

 
           
             401  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            401 

Cys Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
  1               5                  10 

 
           
             402  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            402 

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Cys 
  1               5                  10 

 
           
             403  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            403 

Cys Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile 
  1               5                  10 

 
           
             404  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            404 

Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Cys 
  1               5                  10 

 
           
             405  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            405 

Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
  1               5                  10 

 
           
             406  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            406 

Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Cys 
  1               5                  10 

 
           
             407  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            407 

Cys Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu 
  1               5                  10 

 
           
             408  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            408 

Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Cys 
  1               5                  10 

 
           
             409  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            409 

Cys Ile Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg 
  1               5                  10 

 
           
             410  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            410 

Thr Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys 
  1               5                  10 

 
           
             411  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            411 

Cys Ile Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys 
  1               5                  10 

 
           
             412  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            412 

Ala Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Cys 
  1               5                  10 

 
           
             413  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            413 

Cys Ile Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser 
  1               5                  10 

 
           
             414  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            414 

Glu Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Cys 
  1               5                  10 

 
           
             415  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            415 

Cys Lys Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn 
  1               5                  10 

 
           
             416  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            416 

Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Cys 
  1               5                  10 

 
           
             417  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            417 

Cys Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr 
  1               5                  10 

 
           
             418  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            418 

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys 
  1               5                  10 

 
           
             419  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            419 

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys 
  1               5                  10 

 
           
             420  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            420 

Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Cys 
  1               5                  10 

 
           
             421  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            421 

Cys Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
  1               5                  10 

 
           
             422  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            422 

Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys 
  1               5                  10 

 
           
             423  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            423 

Cys Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys 
  1               5                  10 

 
           
             424  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            424 

Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Cys 
  1               5                  10 

 
           
             425  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            425 

Cys Asn Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr 
  1               5                  10 

 
           
             426  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            426 

Thr Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Cys 
  1               5                  10 

 
           
             427  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            427 

Cys Thr Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp 
  1               5                  10 

 
           
             428  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            428 

Trp Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Cys 
  1               5                  10 

 
           
             429  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            429 

Cys Cys Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val 
  1               5                  10 

 
           
             430  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            430 

Ala Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Cys 
  1               5                  10 

 
           
             431  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            431 

Cys Gly Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys 
  1               5                  10 

 
           
             432  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            432 

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Cys 
  1               5                  10 

 
           
             433  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            433 

Cys Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
  1               5                  10 

 
           
             434  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            434 

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Cys 
  1               5                  10 

 
           
             435  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            435 

Cys Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg 
  1               5                  10 

 
           
             436  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            436 

Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Cys 
  1               5                  10 

 
           
             437  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            437 

Cys Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
  1               5                  10 

 
           
             438  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            438 

Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Cys 
  1               5                  10 

 
           
             439  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            439 

Cys Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
  1               5                  10 

 
           
             440  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            440 

Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Cys 
  1               5                  10 

 
           
             441  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            441 

Cys Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr 
  1               5                  10 

 
           
             442  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            442 

Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Cys 
  1               5                  10 

 
           
             443  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            443 

Cys Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr 
  1               5                  10 

 
           
             444  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            444 

Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Cys 
  1               5                  10 

 
           
             445  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            445 

Cys Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys 
  1               5                  10 

 
           
             446  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            446 

Pro Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Cys 
  1               5                  10 

 
           
             447  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            447 

Cys Lys Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu 
  1               5                  10 

 
           
             448  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            448 

Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Cys 
  1               5                  10 

 
           
             449  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            449 

Cys Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr 
  1               5                  10 

 
           
             450  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            450 

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Cys 
  1               5                  10 

 
           
             451  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            451 

Cys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr 
  1               5                  10 

 
           
             452  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            452 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Cys 
  1               5                  10 

 
           
             453  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            453 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
  1               5                  10 

 
           
             454  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            454 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Cys 
  1               5                  10 

 
           
             455  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            455 

Cys Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro 
  1               5                  10 

 
           
             456  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            456 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
  1               5                  10 

 
           
             457  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            457 

Cys Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
  1               5                  10 

 
           
             458  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            458 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala Cys 
  1               5                  10 

 
           
             459  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            459 

Cys Tyr Glu Thr Val Arg Val Pro Gly Cys Ala His 
  1               5                  10 

 
           
             460  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            460 

Glu Thr Val Arg Val Pro Gly Cys Ala His His Cys 
  1               5                  10 

 
           
             461  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            461 

Cys Thr Val Arg Val Pro Gly Cys Ala His His Ala 
  1               5                  10 

 
           
             462  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            462 

Val Arg Val Pro Gly Cys Ala His His Ala Asp Cys 
  1               5                  10 

 
           
             463  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            463 

Cys Arg Val Pro Gly Cys Ala His His Ala Asp Ser 
  1               5                  10 

 
           
             464  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            464 

Val Pro Gly Cys Ala His His Ala Asp Ser Leu Cys 
  1               5                  10 

 
           
             465  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            465 

Cys Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr 
  1               5                  10 

 
           
             466  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            466 

Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Cys 
  1               5                  10 

 
           
             467  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            467 

Cys Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr 
  1               5                  10 

 
           
             468  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            468 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Cys 
  1               5                  10 

 
           
             469  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            469 

Cys His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
  1               5                  10 

 
           
             470  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            470 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Cys 
  1               5                  10 

 
           
             471  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            471 

Cys Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr 
  1               5                  10 

 
           
             472  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            472 

Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys 
  1               5                  10 

 
           
             473  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            473 

Cys Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys 
  1               5                  10 

 
           
             474  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            474 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys 
  1               5                  10 

 
           
             475  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            475 

Cys Tyr Thr Tyr Pro Val Ala Thr Gln Cys His Cys 
  1               5                  10 

 
           
             476  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N-terminal 
      cysteine  
             
           
            476 

Thr Tyr Pro Val Ala Thr Gln Cys His Cys Gly Cys 
  1               5                  10 

 
           
             477  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- 
      terminal cysteine  
             
           
            477 

Cys Tyr Pro Val Ala Thr Gln Cys His Cys Gly Lys 
  1               5                  10 

 
           
             478  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            478 

Pro Val Ala Thr Gln Cys His Cys Gly Lys Cys Cys 
  1               5                  10 

 
           
             479  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            479 

Cys Val Ala Thr Gln Cys His Cys Gly Lys Cys Asp 
  1               5                  10 

 
           
             480  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            480 

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Cys 
  1               5                  10 

 
           
             481  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            481 

Cys Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp 
  1               5                  10 

 
           
             482  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            482 

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Cys 
  1               5                  10 

 
           
             483  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            483 

Cys Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr 
  1               5                  10 

 
           
             484  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            484 

His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
  1               5                  10 

 
           
             485  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            485 

Cys Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
  1               5                  10 

 
           
             486  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            486 

Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Cys 
  1               5                  10 

 
           
             487  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            487 

Cys Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val 
  1               5                  10 

 
           
             488  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            488 

Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Cys 
  1               5                  10 

 
           
             489  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            489 

Cys Asp Ser Asp Ser Thr Asp Cys Thr Val Arg Gly 
  1               5                  10 

 
           
             490  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            490 

Ser Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Cys 
  1               5                  10 

 
           
             491  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            491 

Cys Asp Ser Thr Asp Cys Thr Val Arg Gly Leu Gly 
  1               5                  10 

 
           
             492  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            492 

Ser Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Cys 
  1               5                  10 

 
           
             493  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            493 

Cys Thr Asp Cys Thr Val Arg Gly Leu Gly Pro Ser 
  1               5                  10 

 
           
             494  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            494 

Asp Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys 
  1               5                  10 

 
           
             495  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            495 

Cys Cys Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys 
  1               5                  10 

 
           
             496  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            496 

Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Cys 
  1               5                  10 

 
           
             497  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            497 

Cys Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe 
  1               5                  10 

 
           
             498  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            498 

Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Cys 
  1               5                  10 

 
           
             499  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            499 

Cys Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu 
  1               5                  10 

 
           
             500  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            500 

Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Cys 
  1               5                  10 

 
           
             501  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            501 

Cys Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
  1               5                  10 

 
           
             502  
             12  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence 11-mer 
      peptide derived from hFSH with an additional C- or N- terminal 
      cysteine  
             
           
            502 

Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu Cys 
  1               5                  10 

 
           
             503  
             24  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide, containing a thioether linkage within the 
      sequence  
             
           
            503 

Val Tyr Glu Thr Val Arg Val Pro Gly Cys Ala Cys Ala His His Ala 
  1               5                  10                  15 

Asp Ser Leu Tyr Thr Tyr Pro Val 
             20 

 
           
             504  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            504 

Lys Thr Ala Thr Phe Lys Glu Leu Val Tyr Glu Thr Cys 
  1               5                  10 

 
           
             505  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            505 

Cys Thr Ala Thr Phe Lys Glu Leu Val Tyr Glu Thr Val 
  1               5                  10 

 
           
             506  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            506 

Ala Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Cys 
  1               5                  10 

 
           
             507  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            507 

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
  1               5                  10 

 
           
             508  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            508 

Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Cys 
  1               5                  10 

 
           
             509  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            509 

Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Ala Cys 
  1               5                  10 

 
           
             510  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            510 

Cys Leu Val Tyr Glu Thr Val Arg Val Pro Gly Ala Ala 
  1               5                  10 

 
           
             511  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            511 

Val Tyr Glu Thr Val Arg Val Pro Gly Ala Ala His Cys 
  1               5                  10 

 
           
             512  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            512 

Cys Tyr Glu Thr Val Arg Val Pro Gly Ala Ala His His 
  1               5                  10 

 
           
             513  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            513 

Glu Thr Val Arg Val Pro Gly Ala Ala His His Ala Cys 
  1               5                  10 

 
           
             514  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            514 

Cys Thr Val Arg Val Pro Gly Ala Ala His His Ala Asp 
  1               5                  10 

 
           
             515  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            515 

Val Arg Val Pro Gly Ala Ala His His Ala Asp Ser Cys 
  1               5                  10 

 
           
             516  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            516 

Cys Arg Val Pro Gly Ala Ala His His Ala Asp Ser Leu 
  1               5                  10 

 
           
             517  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            517 

Val Pro Gly Ala Ala His His Ala Asp Ser Leu Tyr Cys 
  1               5                  10 

 
           
             518  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            518 

Cys Pro Gly Ala Ala His His Ala Asp Ser Leu Tyr Thr 
  1               5                  10 

 
           
             519  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            519 

Gly Ala Ala His His Ala Asp Ser Leu Tyr Thr Tyr Cys 
  1               5                  10 

 
           
             520  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            520 

Cys Ala Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro 
  1               5                  10 

 
           
             521  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            521 

Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Cys 
  1               5                  10 

 
           
             522  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            522 

Cys His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala 
  1               5                  10 

 
           
             523  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            523 

His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Cys 
  1               5                  10 

 
           
             524  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            524 

Cys Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln 
  1               5                  10 

 
           
             525  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            525 

Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Ala Cys 
  1               5                  10 

 
           
             526  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            526 

Cys Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Ala His 
  1               5                  10 

 
           
             527  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            527 

Leu Tyr Thr Tyr Pro Val Ala Thr Gln Ala His Ala Cys 
  1               5                  10 

 
           
             528  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            528 

Cys Tyr Thr Tyr Pro Val Ala Thr Gln Ala His Ala Gly 
  1               5                  10 

 
           
             529  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            529 

Thr Tyr Pro Val Ala Thr Gln Ala His Ala Gly Lys Cys 
  1               5                  10 

 
           
             530  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            530 

Cys Tyr Pro Val Ala Thr Gln Ala His Ala Gly Lys Ala 
  1               5                  10 

 
           
             531  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            531 

Pro Val Ala Thr Gln Ala His Ala Gly Lys Ala Asp Cys 
  1               5                  10 

 
           
             532  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            532 

Cys Val Ala Thr Gln Ala His Ala Gly Lys Ala Asp Ser 
  1               5                  10 

 
           
             533  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            533 

Ala Thr Gln Ala His Ala Gly Lys Ala Asp Ser Asp Cys 
  1               5                  10 

 
           
             534  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            534 

Cys Thr Gln Ala His Ala Gly Lys Ala Asp Ser Asp Ser 
  1               5                  10 

 
           
             535  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            535 

Gln Ala His Ala Gly Lys Ala Asp Ser Asp Ser Thr Cys 
  1               5                  10 

 
           
             536  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            536 

Cys Ala His Ala Gly Lys Ala Asp Ser Asp Ser Thr Asp 
  1               5                  10 

 
           
             537  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      derived peptide  
             
           
            537 

Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr Gln Cys 
  1               5                  10 

 
           
             538  
             40  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence bio- 
      tinylated hFSH derived peptide  
             
           
            538 

Glu Lys Glu Glu Ala Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Ala 
  1               5                  10                  15 

Ala Gly Tyr Ala Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg 
             20                  25                  30 

Pro Lys Ile Gln Lys Thr Ala Thr 
         35                  40 

 
           
             539  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            539 

Ile Ser Glu Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg Cys Val 
  1               5                  10                  15 

Asp Tyr Met Thr Gln Thr Arg Gly Gln Arg Ser Ser Leu Ala 
             20                  25                  30 

 
           
             540  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            540 

Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Cys Met 
  1               5                  10                  15 
Thr Gln Thr Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn 
             20                  25                  30 

 
           
             541  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            541 

Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met Cys Thr 
  1               5                  10                  15 

Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser Ser 
             20                  25                  30 

 
           
             542  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            542 

Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met Thr Gln Thr Cys Gln 
  1               5                  10                  15 

Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg 
             20                  25                  30 

 
           
             543  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            543 

Leu Arg Gln Glu Val Asp Tyr Met Thr Gln Thr Arg Gly Gln Cys Ser 
  1               5                  10                  15 

Leu Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp 
             20                  25                  30 

 
           
             544  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            544 

Glu Val Asp Tyr Met Thr Gln Thr Arg Gly Gln Arg Ser Ser Cys Glu 
  1               5                  10                  15 

Asp Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr 
             20                  25                  30 

 
           
             545  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            545 

Tyr Met Thr Gln Thr Arg Gly Gln Arg Ser Ser Leu Ala Glu Cys Glu 
  1               5                  10                  15 

Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe 
             20                  25                  30 

 
           
             546  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            546 

Gln Thr Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Cys Tyr 
  1               5                  10                  15 

Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
             20                  25                  30 

 
           
             547  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            547 

Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser Ser Tyr Cys Gly 
  1               5                  10                  15 
Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp Leu Cys Asn 
             20                  25                  30 

 
           
             548  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            548 

Ser Ser Leu Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg Gly Cys Met 
  1               5                  10                  15 

Thr Tyr Thr Glu Phe Asp Tyr Asp Leu Cys Asn Glu Val Val 
             20                  25                  30 

 
           
             549  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            549 

Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Cys Thr 
  1               5                  10                  15 

Glu Phe Asp Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr 
             20                  25                  30 

 
           
             550  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            550 

Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Cys Asp 
  1               5                  10                  15 

Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro 
             20                  25                  30 

 
           
             551  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            551 

Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Cys Leu 
  1               5                  10                  15 

Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp 
             20                  25                  30 

 
           
             552  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage 
      within the sequence  
             
           
            552 

Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp Leu Cys Glu 
  1               5                  10                  15 

Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala Phe Asn 
             20                  25                  30 

 
           
             553  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            553 

Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp Leu Cys Asn Glu Cys Asp 
  1               5                  10                  15 

Val Thr Cys Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu 
             20                  25                  30 

 
           
             554  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            554 

Tyr Thr Glu Phe Asp Tyr Asp Leu Cys Asn Glu Val Val Asp Cys Cys 
  1               5                  10                  15 

Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu Asp Ile Met 
             20                  25                  30 

 
           
             555  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            555 

Phe Asp Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys Cys Lys 
  1               5                  10                  15 
Pro Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn 
             20                  25                  30 

 
           
             556  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            556 

Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Cys Ala 
  1               5                  10                  15 

Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg 
             20                  25                  30 

 
           
             557  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            557 

Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala Cys Pro 
  1               5                  10                  15 

Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu Ile 
             20                  25                  30 

 
           
             558  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            558 

Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Asp 
  1               5                  10                  15 

Ile Met Gly Tyr Asn Ile Leu Arg Val Leu Ile Trp Phe Ile 
             20                  25                  30 

 
           
             559  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            559 

Thr Cys Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu Asp Cys Gly 
  1               5                  10                  15 

Tyr Asn Ile Leu Arg Val Leu Ile Trp Phe Ile Ser Ile Leu 
             20                  25                  30 

 
           
             560  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            560 

Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Cys Ile 
  1               5                  10                  15 

Leu Arg Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr 
             20                  25                  30 

 
           
             561  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            561 

Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Cys Val 
  1               5                  10                  15 

Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile 
             20                  25                  30 

 
           
             562  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            562 

Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Cys Trp 
  1               5                  10                  15 

Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
             20                  25                  30 

 
           
             563  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            563 

Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu Ile Trp Cys Ser 
  1               5                  10                  15 

Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu Val Ile Leu 
             20                  25                  30 

 
           
             564  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            564 

Met Gly Tyr Asn Ile Leu Arg Val Leu Ile Trp Phe Ile Ser Cys Ala 
  1               5                  10                  15 

Ile Thr Gly Asn Ile Ile Val Leu Val Ile Leu Thr Thr Ser 
             20                  25                  30 

 
           
             565  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            565 

Asn Ile Leu Arg Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Cys Gly 
  1               5                  10                  15 

Asn Ile Ile Val Leu Val Ile Leu Thr Thr Ser Gln Tyr Lys 
             20                  25                  30 

 
           
             566  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            566 

Arg Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Cys Ile 
  1               5                  10                  15 

Val Leu Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val 
             20                  25                  30 

 
           
             567  
             30  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence hFSH 
      receptor derived peptide, containing a thioether linkage within 
      the sequence  
             
           
            567 

Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Cys Val 
  1               5                  10                  15 

Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe 
             20                  25                  30 

 
           
             568  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            568 

Met Glu Arg Pro Tyr Ala Asx Pro Val Glu Ser Asx Xaa 
  1               5                  10 

 
           
             569  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            569 

Xaa Glu Arg Pro Tyr Ala Asx Pro Val Glu Ser Asx Asp 
  1               5                  10 

 
           
             570  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            570 

Arg Pro Tyr Ala Asx Pro Val Glu Ser Asx Asp Arg Xaa 
  1               5                  10 

 
           
             571  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            571 

Xaa Pro Tyr Ala Asx Pro Val Glu Ser Asx Asp Arg Arg 
  1               5                  10 

 
           
             572  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            572 

Tyr Ala Asx Pro Val Glu Ser Asx Asp Arg Arg Phe Xaa 
  1               5                  10 

 
           
             573  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            573 

Xaa Ala Asx Pro Val Glu Ser Asx Asp Arg Arg Phe Ser 
  1               5                  10 

 
           
             574  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            574 

Asx Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Xaa 
  1               5                  10 

 
           
             575  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            575 

Xaa Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser 
  1               5                  10 

 
           
             576  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            576 

Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Asp Xaa 
  1               5                  10 

 
           
             577  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            577 

Xaa Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Asp Glu 
  1               5                  10 

 
           
             578  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            578 

Ser Asx Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Xaa 
  1               5                  10 

 
           
             579  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            579 

Xaa Asx Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr 
  1               5                  10 

 
           
             580  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            580 

Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg Xaa 
  1               5                  10 

 
           
             581  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            581 

Xaa Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His 
  1               5                  10 

 
           
             582  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            582 

Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His Ile Xaa 
  1               5                  10 

 
           
             583  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            583 

Xaa Phe Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg 
  1               5                  10 

 
           
             584  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            584 

Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile Xaa 
  1               5                  10 

 
           
             585  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            585 

Xaa Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His 
  1               5                  10 

 
           
             586  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            586 

Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Xaa 
  1               5                  10 

 
           
             587  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            587 

Xaa Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly 
  1               5                  10 

 
           
             588  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            588 

Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Xaa 
  1               5                  10 

 
           
             589  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            589 

Xaa Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys 
  1               5                  10 

 
           
             590  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            590 

Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Xaa 
  1               5                  10 

 
           
             591  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            591 

Xaa Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
  1               5                  10 

 
           
             592  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            592 

His Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Xaa 
  1               5                  10 

 
           
             593  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            593 

Xaa Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Asx 
  1               5                  10 

 
           
             594  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            594 

Arg Ile His Thr Gly Gln Lys Pro Phe Gln Asx Arg Xaa 
  1               5                  10 

 
           
             595  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            595 

Xaa Ile His Thr Gly Gln Lys Pro Phe Gln Asx Arg Ile 
  1               5                  10 

 
           
             596  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            596 

His Thr Gly Gln Lys Pro Phe Gln Asx Arg Ile Asx Xaa 
  1               5                  10 

 
           
             597  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            597 

Xaa Thr Gly Gln Lys Pro Phe Gln Asx Arg Ile Asx Met 
  1               5                  10 

 
           
             598  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            598 

Gly Gln Lys Pro Phe Gln Asx Arg Ile Asx Met Arg Xaa 
  1               5                  10 

 
           
             599  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            599 

Xaa Gln Lys Pro Phe Gln Asx Arg Ile Asx Met Arg Asn 
  1               5                  10 

 
           
             600  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            600 

Lys Pro Phe Gln Asx Arg Ile Asx Met Arg Asn Phe Xaa 
  1               5                  10 

 
           
             601  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            601 

Xaa Pro Phe Gln Asx Arg Ile Asx Met Arg Asn Phe Ser 
  1               5                  10 

 
           
             602  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            602 

Phe Gln Asx Arg Ile Asx Met Arg Asn Phe Ser Arg Xaa 
  1               5                  10 

 
           
             603  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            603 

Xaa Gln Asx Arg Ile Asx Met Arg Asn Phe Ser Arg Ser 
  1               5                  10 

 
           
             604  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            604 

Asx Arg Ile Asx Met Arg Asn Phe Ser Arg Ser Asp Xaa 
  1               5                  10 

 
           
             605  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            605 

Xaa Arg Ile Asx Met Arg Asn Phe Ser Arg Ser Asp His 
  1               5                  10 

 
           
             606  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            606 

Ile Asx Met Arg Asn Phe Ser Arg Ser Asp His Leu Xaa 
  1               5                  10 

 
           
             607  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            607 

Xaa Asx Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
  1               5                  10 

 
           
             608  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            608 

Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr Xaa 
  1               5                  10 

 
           
             609  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            609 

Xaa Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His 
  1               5                  10 

 
           
             610  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            610 

Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Xaa 
  1               5                  10 

 
           
             611  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            611 

Xaa Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg 
  1               5                  10 

 
           
             612  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            612 

Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr Xaa 
  1               5                  10 

 
           
             613  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            613 

Xaa Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His 
  1               5                  10 

 
           
             614  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            614 

Ser Asp His Leu Thr Thr His Ile Arg Thr His Thr Xaa 
  1               5                  10 

 
           
             615  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            615 

Xaa Asp His Leu Thr Thr His Ile Arg Thr His Thr Gly 
  1               5                  10 

 
           
             616  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            616 

His Leu Thr Thr His Ile Arg Thr His Thr Gly Glu Xaa 
  1               5                  10 

 
           
             617  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            617 

Xaa Leu Thr Thr His Ile Arg Thr His Thr Gly Glu Lys 
  1               5                  10 

 
           
             618  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            618 

Thr Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Xaa 
  1               5                  10 

 
           
             619  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            619 

Xaa Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
  1               5                  10 

 
           
             620  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            620 

His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Xaa 
  1               5                  10 

 
           
             621  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            621 

Xaa Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Asx 
  1               5                  10 

 
           
             622  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            622 

Arg Thr His Thr Gly Glu Lys Pro Phe Ala Asx Asp Xaa 
  1               5                  10 

 
           
             623  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            623 

Xaa Thr His Thr Gly Glu Lys Pro Phe Ala Asx Asp Ile 
  1               5                  10 

 
           
             624  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            624 

His Thr Gly Glu Lys Pro Phe Ala Asx Asp Ile Asx Xaa 
  1               5                  10 

 
           
             625  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            625 

Xaa Thr Gly Glu Lys Pro Phe Ala Asx Asp Ile Asx Gly 
  1               5                  10 

 
           
             626  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            626 

Gly Glu Lys Pro Phe Ala Asx Asp Ile Asx Gly Arg Xaa 
  1               5                  10 

 
           
             627  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            627 

Xaa Glu Lys Pro Phe Ala Asx Asp Ile Asx Gly Arg Lys 
  1               5                  10 

 
           
             628  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            628 

Lys Pro Phe Ala Asx Asp Ile Asx Gly Arg Lys Phe Xaa 
  1               5                  10 

 
           
             629  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            629 

Xaa Pro Phe Ala Asx Asp Ile Asx Gly Arg Lys Phe Ala 
  1               5                  10 

 
           
             630  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            630 

Phe Ala Asx Asp Ile Asx Gly Arg Lys Phe Ala Arg Xaa 
  1               5                  10 

 
           
             631  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            631 

Xaa Ala Asx Asp Ile Asx Gly Arg Lys Phe Ala Arg Ser 
  1               5                  10 

 
           
             632  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            632 

Asx Asp Ile Asx Gly Arg Lys Phe Ala Arg Ser Asp Xaa 
  1               5                  10 

 
           
             633  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            633 

Xaa Asp Ile Asx Gly Arg Lys Phe Ala Arg Ser Asp Glu 
  1               5                  10 

 
           
             634  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            634 

Ile Asx Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Xaa 
  1               5                  10 

 
           
             635  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            635 

Xaa Asx Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys 
  1               5                  10 

 
           
             636  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            636 

Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg Xaa 
  1               5                  10 

 
           
             637  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            637 

Xaa Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His 
  1               5                  10 

 
           
             638  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            638 

Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Xaa 
  1               5                  10 

 
           
             639  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            639 

Xaa Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys 
  1               5                  10 

 
           
             640  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            640 

Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys Ile Xaa 
  1               5                  10 

 
           
             641  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            641 

Xaa Arg Ser Asp Glu Arg Lys Arg His Thr Lys Ile His 
  1               5                  10 

 
           
             642  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            642 

Ser Asp Glu Arg Lys Arg His Thr Lys Ile His Leu Xaa 
  1               5                  10 

 
           
             643  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            643 

Xaa Asp Glu Arg Lys Arg His Thr Lys Ile His Leu Arg 
  1               5                  10 

 
           
             644  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            644 

Glu Arg Lys Arg His Thr Lys Ile His Leu Arg Gln Xaa 
  1               5                  10 

 
           
             645  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            645 

Xaa Arg Lys Arg His Thr Lys Ile His Leu Arg Gln Lys 
  1               5                  10 

 
           
             646  
             13  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger wherein X stands for 
      unknown  
             
           
            646 

Lys Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Xaa 
  1               5                  10 

 
           
             647  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      receptor binding sequence,  unspecified AA 
      sequence of fig 10D containing a thioether linkage 
      within the sequence  
             
           
            647 

Cys Ser Asp His Leu Thr Thr His Ile Arg Thr His Thr Cys Cys Thr 
  1               5                  10                  15 

Gly Gln Lys Pro Phe Gln Asx Arg Ile Asx Met 
             20                  25 

 
           
             648  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      receptor binding sequence,  unspecified AA 
      sequence of fig 10D containing a thioether linkage 
      within the sequence  
             
           
            648 

Cys Ser Asp His Leu Thr Thr His Ile Arg Thr His Thr Cys Gly Gln 
  1               5                  10                  15 

Lys Pro Phe Gln Asx Arg Ile Asx Met Arg Cys 
             20                  25 

 
           
             649  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      receptor binding sequence,  unspecified AA 
      sequence of fig 10D containing a thioether linkage 
      within the sequence  
             
           
            649 

Cys Ser Asp His Leu Thr Thr His Ile Arg Thr His Thr Cys Cys Gln 
  1               5                  10                  15 

Lys Pro Phe Gln Asx Arg Ile Asx Met Arg Asn 
             20                  25 

 
           
             650  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            650 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Cys Leu 
  1               5                  10                  15 

Thr Arg His Ile Arg Ile His Thr Gly Gln Lys 
             20                  25 

 
           
             651  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            651 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser His Ile 
  1               5                  10                  15 

Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys 
             20                  25 

 
           
             652  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            652 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Cys Ile 
  1               5                  10                  15 
Arg Ile His Thr Gly Gln Lys Pro Phe Gln Asx 
             20                  25 

 
           
             653  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            653 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Lys Pro 
  1               5                  10                  15 

Phe Gln Asx Arg Ile Asx Met Arg Asn Phe Cys 
             20                  25 

 
           
             654  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            654 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Ile Asx 
  1               5                  10                  15 

Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Cys 
             20                  25 

 
           
             655  
             27  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            655 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Cys Asx 
  1               5                  10                  15 

Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys 
             20                  25 

 
           
             656  
             26  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            656 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Cys Phe 
  1               5                  10                  15 

Ala Arg Ser Asp Glu Arg Lys His Thr Lys 
             20                  25 

 
           
             657  
             26  
             PRT  
             Artificial Sequence  
             
               Description of Artificial Sequence peptide 
      derived from a zinc-finger, containing a 
      thioether linkage within the sequence  
             
           
            657 

Cys Cys Pro Val Glu Ser Asx Asp Arg Arg Phe Ser Arg Ser Ala Arg 
  1               5                  10                  15 

Ser Asp Glu Arg Lys His Thr Lys Ile Cys 
             20                  25 

 
           
             658  
             12  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      nucleic acid sequence linked to label-Transportan 
      amide, containing a thioether linkage within the 
      sequence  
             
           
            658 

catgcgtatt tg                                                         12 

 
           
             659  
             12  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      nucleic acid sequence linked to label-Transportan 
      amide, containing a thioether linkage within the 
      sequence  
             
           
            659 

ctgcgtattt gc                                                         12 

 
           
             660  
             12  
             DNA  
             Artificial Sequence  
             
               Description of Artificial Sequence unspecified 
      nucleic acid sequence linked to label-Transportan 
      amide, containing a thioether linkage within the 
      sequence  
             
           
            660 

cgcgtatttg ct                                                         12