Abstract:
The present invention relates to methods for identifying compounds that modulate the translation machinery and methods of diagnosing cancer related to deregulation of the translation machinery. In particular, the methods and diagnostic tests include determining an association between one or more targets and one or more components of the riboproteome and treating a subject with cancer by administering a compound that modulates the association between one or more targets and one or more components of the riboproteome.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application claims the benefit of U.S. Provisional Application No. 61/879,565, filed Sep. 18, 2013, hereby incorporated by reference in its entirety. 
     
    
     STATEMENT AS TO FEDERALLY SPONSORED RESEARCH 
       [0002]    This invention was made with government support under grant number RC1 DK087679 awarded by the National Cancer Institute. The government has certain rights in this invention. 
     
    
     BACKGROUND OF THE INVENTION 
       [0003]    The present invention relates to methods for identifying compounds that modulate the translation machinery and methods of diagnosing cancer related to deregulation of the translation machinery. 
         [0004]    Increasing evidence points to an important role for the ribosome in the regulation of biological processes, and as a target for deregulation in disease. Key regulators of translation are specifically targeted in human diseases, including cancer. Indeed, recent data suggest that RNA binding proteins (RBPs) are frequently associated with disease. Additionally, deficiency and mutation of ribosome and ribosome biogenesis proteins themselves are associated with disease and developmental abnormalities, including Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome (SDS) and X-linked dyskeratosis congenita (X-DC). However, a more global approach to systematically determine in greater detail the players that coordinate translation is currently lacking. Such an approach will in turn enable the identification of key regulators of translation in specific conditions, and help better elucidate the role that these proteins play in disease pathology and to identify novel markers and targets for disease diagnosis and therapy. 
       SUMMARY OF THE INVENTION 
       [0005]    The invention features a method of identifying a compound for the treatment of cancer, the method including: a) providing one or more targets and one or more components of the riboproteome known to associate with the target, b) contacting the combined materials of a) with a compound, and c) monitoring an alteration in the target or the component of the riboproteome, wherein a modulation in the association between the target and the component of the riboproteome identifies the compound as a potential therapeutic for the treatment of cancer. In certain embodiments, the alteration is seen in both the target and the component of the riboproteome. In other embodiments, the alteration is in the association between the target and the component of the riboproteome. 
         [0006]    The invention also features a method of diagnosing a subject as having, or having a predisposition to a particular type of cancer, the method including a) determining an association between one or more targets and one or more components of the riboproteome in the subject, and b) comparing the level of association to a normal reference, wherein a change in the level of association diagnoses the subject as having a particular type of cancer, and c) treating the subject for the particular type of cancer by administering a compound that modulates the association between the target and the component of the riboproteome. 
         [0007]    In all aspects of the invention, the cancer is a cancer resulting from a change in the level of association between the target and the component of the riboproteome. In particular embodiments, the cancer resulting from the change in the level of the association between the target and the component of the riboproteome is selected from the group consisting of: acute myeloid leukemia, adenoid cystic carcinoma, bladder cancer, bladder urothelial carcinoma, brain lower grade glioma, breast invasive carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, colon and rectum adenocarcinoma, glioblastoma, glioblastoma multiforme, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, lymphoid neoplasm diffuse large b-cell lymphoma, ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, prostate adenocarcinoma, sarcoma, skin cutaneous melanoma, stomach adenocarcinoma, thyroid carcinoma, and uterine corpus endometrial carcinoma. 
         [0008]    In one aspect, the one or more targets is selected from the group consisting of: a RNA binding protein, a metabolic enzyme, a cell adhesion molecule, a component of the proteasome, a component of the ubiquitination machinery, a component of the neddylation machinery, and a signaling protein. In certain embodiments, the one or more targets is a target listed in Table 1 or Table 2. 
         [0009]    In a second aspect, the one or more components of the riboproteome is a component listed in Table 3 or Table 4. 
         [0010]    In a third aspect, the compound is a small molecule, an RNAi agent, a soluble polypeptide, an antibody, or an antigen-binding fragment. In one embodiment, the compound specifically interacts with the one or more targets. In another embodiment, the compound inhibits or promotes the activity of the one or more targets. Ina third embodiment, the compound specifically interacts with the one or more components of the riboproteome. In a fourth embodiment, the compound interacts with a secondary target to modulate the association between the target and the component of the riboproteome. 
         [0011]    In certain aspects of the invention, the one or more targets is myristoylated alanine-rich C kinase substrate (MARCKS) or La-related protein 1 (LARP1). In other embodiments, the particular type of cancer is prostate adenocarcinoma. 
         [0012]    Finally, the invention also features a method of diagnosing a subject as having, or having a predisposition to a particular type of cancer or predicting a response to treatment of a particular type of cancer, the method including: a) obtaining a riboproteome profile from the subject, b) identifying changes in the riboproteome profile compared to a normal reference, and c) treating the subject or providing an improved treatment regime based on the changes in the riboproteome profile. 
       DEFINITIONS 
       [0013]    By “riboproteome” is meant the proteins that constitute the actively translating ribosome. The proteins of the riboproteome can associate with (i) the ribosome itself, and which may be required for either directing translation or quality control of nascent proteins, or (ii) mRNAs undergoing active translation. 
         [0014]    By “riboproteome profile” is meant the genes, proteins, combination of genes, combination of proteins present in the riboproteome that make up the entire landscape of the riboproteome in a subject. 
         [0015]    By “changes in the riboproteome profile” is meant a reduction, amplification, appearance, or disappearance in a gene, protein, combinations of genes, or combinations of proteins found in the riboproteome profile when compared to a normal reference. Changes in the riboproteome profile may represent indicators that can help to classify and/or stratify specific patient subgroups that in turn can provide a diagnosis and/or prognosis for treatment of a cancer resulting from a change in the level of association between the target and the component of the riboproteome. 
         [0016]    By “an alteration in the target or the component of the riboproteome” is meant a reduction, amplification, appearance, or disappearance of the target or the component of the riboproteome. 
         [0017]    By “association between the target and the component of the riboproteome” is meant a physical interaction between a target and a component, or an interaction that is mediated by another macromolecule. 
         [0018]    By “modulation or modulates” is meant an increase or decrease in association between the target and the component of the riboproteome as compared to a control. A compound that modulates the association between the target and the component of the riboproteome can affect upstream or downstream signaling events that lead to modulation of the association between the target and the component of the riboproteome or directly affect the association between the target and the component of the riboproteome itself. 
         [0019]    By “a change in the level of association” is meant an increase or decrease in the gene expression, protein expression, and/or activity of the target or the component of the riboproteome which leads to an increase or decrease in association of the target to the component of the riboproteome when compared to a control (e.g., a decrease of at least 2-fold, e.g., from about 2-fold to about 150-fold, e.g., from 5-fold to 150-fold, from 5-fold to 100-fold, from 10-fold to 150-fold, from 10-fold to 100-fold, from 50-fold to 150-fold, from 50-fold to 100-fold, from 75-fold to 150-fold, or from 75-fold to 100-fold, as compared to a control, an increase of at least 2-fold, e.g., from about 2-fold to about 150-fold, e.g., from 5-fold to 150-fold, from 5-fold to 100-fold, from 10-fold to 150-fold, from 10-fold to 100-fold, from 50-fold to 150-fold, from 50-fold to 100-fold, from 75-fold to 150-fold, or from 75-fold to 100-fold, as compared to a control). 
         [0020]    By “specifically interacts” is meant a compound that produces a desired effect in one macromolecule (e.g., the one or more targets) without influencing and/or creating adverse effects in other macromolecules and subtypes thereof. Specific interaction can be determined by binding kinetics (e.g., degree of interaction between a compound with a macromolecule, e.g., an increase in ligand-receptor affinity, e.g., a decrease in dissociation constant (K D ) of 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 20-fold, 30-fold, 100-fold, or 200-fold, a decrease dose (e.g., a decrease by 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95%) of the compound compared to a reference compound). Specific interaction can also be a measure of local accumulation of a compound in the macromolecule compared to accumulation in other macromolecules and subtypes thereof (e.g., an increase in accumulation by 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% at the desired macromolecule compared to a reference agent or compound). Specific interaction can also be an increase in efficacy and/or potency of a compound (e.g., an increase by 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% compared to a reference compound). 
         [0021]    By “inhibits the activity” is meant a compound that decreases or reduces gene expression, protein expression, or activity (e.g., enzymatic activity) of the target, as defined herein, compared to a control (e.g., a decrease by 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95%, as compared to a control or a normal reference sample). By “promotes the activity” is meant a compound that increases or enhances gene expression, protein expression, or activity (e.g., enzymatic activity) of the target, as defined herein, compared to a control (e.g., an increase of 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95%, as compared to a control or a normal reference sample). 
         [0022]    By “secondary target” is meant a target that does not associates with the components of the riboproteome. A secondary target may be a protein involved in a signaling pathway associated with cancer (e.g., mTOR, TORC1, TORC2, Ras, AKT, and PI3K) 
         [0023]    By “normal reference” is meant any sample, standard, standard curve, or level that is used for comparison purposes. A “normal reference” can be, for example, a prior sample taken from the same subject; a sample from a normal healthy subject; a sample from a subject not having a cancer resulting from the change in level of association between a target and a component of the riboproteome, or a sample from a subject that has been treated for a cancer resulting from the change in level of association between a target and a component of the riboproteome. 
         [0024]    By “RNAi agent” is meant any agent or compound that exerts a gene silencing effect by hybridizing a target nucleic acid. RNAi agents include any nucleic acid molecules that are capable of mediating sequence-specific RNAi (e.g., under stringent conditions), for example, a short interfering RNA (sRNA), double-stranded RNA (dsRNA), microRNA (miRNA), short hairpin RNA (shRNA), short interfering oligonucleotide, short interfering nucleic acid, short interfering modified oligonucleotide, short interfering nucleic acid, short interfering modified oligonucleotide, chemically-modified siRNA, post-transcriptional gene silencing RNA (ptgsRNA), and Dicer-substrate RNA (DsiRNA). 
         [0025]    By “treating” is meant obtaining beneficial or desired results, such as clinical results. Beneficial or desired results can include, but are not limited to, alleviation or amelioration of one or more symptoms or conditions; diminishment of extent of disease, disorder, or condition; stabilization (i.e., not worsening) of a state of disease, disorder, or condition; prevention of spread of disease, disorder, or condition; delay or slowing the progress of the disease, disorder, or condition; amelioration or palliation of the disease, disorder, or condition; and remission (whether partial or total), whether detectable or undetectable. 
         [0026]    By “amount sufficient” of an agent is meant the amount of the agent sufficient to effect beneficial or desired result (e.g., treatment of a cancer resulting from a change in the level of association of a target and component of the riboproteome), as compared to the response obtained without administration of the composition. 
         [0000]    By “subject” is meant a mammal (e.g., a human). 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0027]      FIGS. 1A-1N  show a quantitative riboproteomics approach to study the composition of riboproteomes. ( FIG. 1A ) Schematic representation of the SILAC-based mass spectrometry experiments. ( FIG. 1B ) Scatter blot with normalized Log 2  (H/L) ratios/Log 10  intensities highlighting the distribution of all quantified proteins between Du145 H and L labeled cells. Note that most of the proteins have a ratio of 1:1 between the light and heavy state and therefore have a value close to 0 on a Log e  axis (Mean 0.0229; Std. Dev. 0.1866). ( FIG. 1C ) Standard scatter blot with normalized Log 2  (H/L) ratios comparing the two N/C datasets (RWPE1 vs. Du145 and PWR1 E vs. Du145). All shared proteins between the datasets are plotted. Both datasets show a highly significant positive correlation (R 2 =0.4662; p=&lt;0.0001). ( FIGS. 1D ,  1 E and  1 F) Standard scatter blots with normalized Log 2  (H/L) ratios/Log 10  Intensities (Normal vs. Cancer n=3, left panel; Cancer vs. Cancer n=3, middle panel; PPC1 DMSO vs. PP242, n=3, right panel) highlighting the distribution of quantified proteins in each screen (cut off values for enriched proteins was 2 standard deviations (2σ) from the mean—dashed red lines). Proteins of interest in either experimental setting are highlighted. ( FIG. 1G ). Density gradient centrifugation of polysomes. ( FIG. 1H ). Protease activity in polysomal fractions. ( FIG. 1I ). Comparison of riboproteomes in different cell lines. ( FIG. 1J ) differences between N/C riboproteome data sets. ( FIG. 1K ). Comparison of cancer cell lines treated with DMSO and rapamycin. ( FIG. 1L ). Comparison of riboproteome from Npm1 wild type and null immortalized MEFs. ( FIG. 1M ). Number of proteins identified using SILAC-based approach. ( FIG. 1N ). Plot of proteins of the large and small subunit of the ribosome in different cell lines. 
           [0028]      FIGS. 2A-2M  show analysis of the prostate riboproteome. ( FIG. 2A ) Venn diagram showing how proteins identified in each of the 5 SILAC experiments utilizing prostate cell lines are shared between each of the individual datasets. Out of total of 1,499 proteins quantified between all experiments, 363 are shared by all 5 experiments. ( FIG. 2B ) Pie chart illustrating the distribution of proteins identified across the various experiments. Proteins identified in a single experiment (30%) are highlighted by the detached blue pie slice, while proteins identified in all 5 experiments (24%) are indicated by a bold border. ( FIG. 2C ) Gene ontology (GO) analysis of the prostate riboproteome highlights multiple different pathways and functional groups that are significantly enriched in the riboproteome. A table of significantly enriched GO terms relating to translation identified by DAVID analysis is shown. ( FIG. 2D ) Venn diagram indicating the extent of overlap between the RNA binding protein (RBP) interactome identified by Castello et al. and the riboproteome constituents described here. ( FIG. 2E ) Pie charts to illustrate the extent to which components of the RBP interactome overlap with the riboproteome. The left panel shows the percentage of identified proteins that are also called within the Castello et al. dataset for the core riboproteomic dataset (i.e. identified in all 5 experiments). Right panel illustrates how the RBP-interactome components identified in the riboproteomic dataset are distributed amongst the various RBP-interactome categories defined by Castello et al. ( FIG. 2F ). Proteins quantified in experiments. ( FIGS. 2G ,  2 H). Comparison of datasets between different cell lines. ( FIG. 2I ). Enrichment of proteins related to protein synthesis, post-translational modification and protein folding. ( FIG. 2J ). Pathway analysis demonstrated EIF2 signaling, regulation of eIF4 and p70S6K signaling, and mTOR signaling pathways to be significantly represented. ( FIG. 2K ). KEGG pathway analysis of proteins identified in all 5 experimental datasets (363/1499) compared to proteins identified in at least 1 experiment (1499). ( FIG. 2L ). RBP proteins identified by Castello et al. and distribution of RBP-interactome. ( FIG. 2M ). Riboproteome breakdown and RBP breakdown quantified in only 1 experiment. 
           [0029]      FIGS. 3A-3M  show alterations to the riboproteome in cancer. ( FIGS. 3A ,  3 G) Forest plot highlighting the enrichment of amplifications amongst riboproteomic genes when compared to background genes in the cBio TCGA dataset. ( FIGS. 3B ,  3 H) A similar forest plot demonstrating significantly less heterozygous deletions amongst riboproteomic genes in the cBio TCGA dataset when compared to background genes. ( FIGS. 3C ,  3 I) Circos plot to illustrate the distribution of all riboproteomic components across the genome. Light shaded bars represent individual riboproteomic components, and their genomic localization, while internal dark regions highlight genomic regions containing riboproteome genes found to be most frequently amplified in the TCGA repository. ( FIGS. 3D ,  3 K) Table detailing the top amplified genes as identified in the TCGA repository, and organized according to genomic loci. ( FIGS. 3E and 3F ) Summary from the TCGA for riboproteome genes in the regions of 3q and 8q respectively, that are found to be frequently amplified in human cancer. Left panels show the number of patients harboring an alteration from the datasets analyzed. As lung squamous cell carcinoma for the 3q locus and breast invasive carcinoma for the 8q locus were found to show high levels of alteration in both cases, the right panels illustrate the types of alteration found in these patients (amplification, homozygous deletion or mutation). ( FIG. 3J ). Amplification of the 1q22 locus in various cancer types. ( FIGS. 3L ,  3 M)3q26 and 1q22 amplification observed in patients from lung adenocarcinoma and breast invasive carcinoma cancer datasets. 
           [0030]      FIGS. 4A-4N  show that riboproteomics uncovers ribosome-associated protein. ( FIG. 4A ) Western blot analysis of total lysates and polysomal fractions from PC3 and Du145 H and L labeled cell lines. Western blots for MARCKS, RpL7a, Integrin β1, RpS6, RpS14 and β-actin are shown. ( FIG. 4B ) Western blot analysis of pooled polysomal fractions showing differential enrichment of phospho-MARCKS and MARCKS from ribosomes of Du145, PC3, PWR1E and RWPE1 cells (right panel) and PC3, PPC1, Du145 and PWR1 E cells (left panel). Ponceau S staining served as a loading control. ( FIG. 4C ) Western blot analysis from pooled polysomal fractions validating ribosome-associated proteins from ribosomes of PC3, PPC1, Du145, RWPE1 and PWR1 E cells. For this analysis, polyribosomes have been isolated from all cell lines and fractions have been pooled to obtain subunits (S, fractions #3-5, see Figure S1A), early light polysomes (L, fractions #6-8, see Figure S1A) and late heavy polysomes (H, fractions #9-11, see  FIG. 1G ). Western blots for Integrin β1, IGF2BP3, hnRNPC1/2, Calmodulin, Hsp27, Hsp60 and NPM are shown. Ponceau S staining served as a loading control. ( FIG. 4D ) PC3 prostate cancer cells were subjected to puromycin-mediated dissociation of ribosome-mRNA complexes to demonstrate a specific association of MARCKS with the ribosome. Protein was isolated from individual fractions (#1-#7) of the sucrose gradients using TCA/DOC precipitation and subjected to western blot analysis for MARCKS. The relative distribution of MARCKS across the sucrose gradient was quantified using the Image J software (http://rsbweb.nih.gov/ij). ( FIG. 4E ) Western blot analysis from protein isolated from individual fractions across the sucrose gradients of PPC1 cell lysates treated with DMSO or PP242. Shift in LARP1 (upper left panels) and RpL4 (lower left panels) proteins can be readily observed upon treatment with the mTOR kinase inhibitor. Right panel: Rate of change between DMSO and PP242 conditions for LARP1 (light shading) and RpL4 (dark shading) from late to early fractions (#9-#3).  FIGS. 4F ,  4 G). Protein enrichment on the polyribosomes of either normal or cancer cells. ( FIG. 4H ). Quantification of proteins associated with polyribosomes of prostate cancer cells. ( FIG. 4I ). Inhibition of mTOR by PP242 identifies a number of proteins that show a rapid and significant disassociation from the riboproteome upon treatment with PP242. ( FIG. 4J ). Western blot analysis of pooled polysomal fractions after puromycin treatment showing loss of RpS6 and RpL13a from polyribosomes. ( FIG. 4K ). Treatment of MN results in LARP1 dissociation with riboproteome components. ( FIG. 4L ). mTOR inhibition can selectively influence binding of LARP1 at the polysome. ( FIG. 4M ). Proteins that show differential association with polysomes from Npm1 wild type and null MEFs. ( FIG. 4N ). Ribonucleoprotein hnRNPC identified to be increased in polysomes of Npm1 null MEFs. 
       
    
    
     DETAILED DESCRIPTION 
       [0031]    There is a pressing need to understand in greater detail the many factors that contribute to ribosome function and the regulation of translation on a global scale. The inventors have analyzed in a non-biased, high-throughput manner the numerous factors that coordinate ribosome function and mRNA translation in several different cell lines and different cellular contexts. 
         [0032]    A SILAC (stable isotope labeling by amino acids in cell culture)-based mass spectrometry approach was applied to comprehensively characterize the proteins that constitute the actively translating ribosome, i.e. the riboproteome, as defined by the proteins associated with (i) the ribosome itself, and which may be required for either directing translation or quality control of nascent proteins, and (ii) by the proteins associated with mRNAs undergoing active translation. 
         [0033]    By employing this high throughput approach to the analysis of proteins associated with actively translating polysomes in various cellular populations and under varying conditions, a comprehensive overview of the riboproteome was obtained. Differential riboproteome components were identified amongst cancer cell lines and in the analysis of genetic and pharmacological perturbations to the riboproteome. A detailed characterization of the prostate riboproteome was presented, and the diversity of proteins that are associated with actively translating polysomes was highlighted. The data identify a number of novel components of the riboproteome, and demonstrate the ability of this approach to address the dynamic nature of the riboproteome upon specific perturbations. 
         [0034]    The findings draw a number of important conclusions relating to the various elements that make up the riboproteome. 
         [0035]    First, by cross referencing data from independent SILAC riboproteomic experiments, and using a comprehensive panel of prostate cell lines, a core group of proteins that are consistently identified in all experimental datasets was identified, while at least 70% of proteins quantified were found in at least 2 experimental datasets. From this global analysis, the dataset was shown to be highly enriched in factors that relate directly to the ribosome, to translational initiation and elongation, and to pathways that are known to regulate and control translation. Importantly, this comprehensive analysis also reveals that the riboproteome consists of significant proportion of RBPs. As recently reported, the mRNA-interactome revealed that a wide variety of proteins previously unappreciated as RBPs, can bind to mRNA (Castello et al., Cell 149:1393-1406, 2012; Baltz et al., Mol Cell 46:674-690, 2012). This diversity of RBP functionality is also observed in those RBPs represented in the dataset. However, there is also a large proportion of proteins that were identified, even as core riboproteome components, that are not annotated as having RNA binding properties, indicating a further layer of functional complexity in those proteins that work to regulate ribosome function and translation. 
         [0036]    Second, the datasets indicate that the diversity within the riboproteome itself may have the capacity to categorize cell types and tissues and, importantly, may specifically contribute to regulation of gene expression within a given cellular compartment. Surprisingly, in the datasets that were analyzed, we the plasticity of the riboproteome does not appear to extend to individual ribosomal proteins themselves that are evenly represented in the various cell types investigated, and they appear to be uniformly altered in response to conditions that impact ribosomal translation, such as mTOR inhibition. 
         [0037]    Third, further unexpected observations have been made by examining globally how the riboproteome may be altered in diseases such as human cancer. It was found that riboproteomic components display frequent copy number amplifications in human cancer, while genomic losses within the riboproteome is significantly less than that for non-riboproteomic genes. It was identified that three genomic loci around 3q26, 8q24, and 1q22 containing genes that appear to be altered in a significant number of patients for several of the cancer subtypes contained in the cBio TCGA database. It is worth noting that both the regions 3q26 and 8q24 contain the oncogenes PIK3CA and MYC respectively. While MYC and PIK3CA are frequently amplified in cancer, there are several examples within the cBio datasets that the riboproteomic genes within these regions may be amplified without co-amplification of the resident oncogene. It is also interesting to note that both MYC and the PI3-kinase signaling pathway represent important regulators of translation themselves. 
         [0038]    Fourth, in addition to characterizing the riboproteome landscape in various cell types, proteins previously not known to be associated with actively translating ribosomes (e.g. MARCKS, Integrin β1 and IGF2BP3) was identified and validated. These proteins represent a number of interesting ribosome interactors and highlight the diversity of proteins that actually participate in translation. In addition, they also point to the potential of these datasets to identify novel regulators of translation. 
         [0039]    Lastly, the data demonstrate that the cancer riboproteome can be pharmacologically modulated for therapy on the basis of this new molecular knowledge. On the one hand, the riboproteome responds dynamically and differentially to cancer drugs (e.g. rapamycin versus PP242), while, on the other hand it&#39;s differential composition could be used to tailor therapies and predict outcomes based on the riboproteomic profile of specific cell types. 
         [0040]    Thus, quantitative, high throughput riboproteomics represents a powerful platform that can be readily applied to various cellular models to uncover how riboproteome composition contributes to organismal function and disease. 
       Targets 
       [0041]    A target can be identified as a protein that shows quantitative differences (e.g., change in gene expression, protein expression, or activity) between normal cells and cancer cell types. In another embodiment, a target can also be identified by comparing the quantitative differences between particular cancer cell types (e.g., cancer cell types that harbor distinct genetic alterations) to identify targets that are specific to certain cancer types. In certain aspects, the change in gene expression, protein expression, or activity may be a decrease, if for example, the target is an oncogenic protein (e.g., a decrease of about 2-fold, 3-fold, 4-fold, 5-fold, 8-fold, 10-fold) as compared to a normal reference (i.e., normal cells, or non-cancerous cells). In other aspects, the change in gene expression, protein expression, or activity may be an increase if, for example, the target is an antitumor target (e.g., an increase of about 2-fold, 3-fold, 4-fold, 5-fold, 8-fold, 10-fold) as compared to a normal reference. 
         [0042]    In another embodiment, a target can be a protein that interacts with either the ribosome itself, the mRNAs that are being actively translated, or interact with other proteins that may have the capacity to interact with both the ribosome and mRNA. 
         [0043]    Exemplary targets include, but is not limited to, those listed in Table 1 and Table 2. 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Targets Associated with the Components of the Riboproteome 
               
             
          
           
               
                 Number 
                 IPI.Prot 
                 GeneSymbol 
                 DAVID.Official 
               
               
                   
               
             
          
           
               
                 1 
                 IPI00395627 
                 CACYBP 
                 CACYBP 
               
               
                 2 
                 IPI00550523 
                 ATL3 
                 ATL3 
               
               
                 3 
                 IPI00794659 
                 RPS20 
                 rps20 
               
               
                 4 
                 IPI00796337 
                 hCG_2017557 
                 PCBP2 
               
               
                 5 
                 IPI00034049 
                 KIAA0221 
                 UPF1 
               
               
                 6 
                 IPI00953461 
                 KIAA0217 
                 LARP4B 
               
               
                 7 
                 IPI00021263 
                 YWHAZ 
                 YWHAZ 
               
               
                 8 
                 IPI00003881 
                 HNRNPF 
                 HNRNPF 
               
               
                 9 
                 IPI00465431 
                 LGALS3 
                 LGALS3 
               
               
                 10 
                 IPI00297982 
                 EIF2G 
                 eif2s3 
               
               
                 11 
                 IPI00005969 
                 CAPZA1 
                 CAPZA1 
               
               
                 12 
                 IPI00018873 
                 NAMPT 
                 NAMPT 
               
               
                 13 
                 IPI00019472 
                 ASCT2 
                 SLC1A5 
               
               
                 14 
                 IPI00295992 
                 ATAD3A 
                 atad3a 
               
               
                 15 
                 IPI00009841 
                 EWSR1 
                 LOC284685 
               
               
                 16 
                 IPI00000581 
                 DKFZp564E242 
                 OTUB1 
               
               
                 17 
                 IPI00013297 
                 HASPP28 
                 LOC645181 
               
               
                 18 
                 IPI00025084 
                 CAPN4 
                 capns1 
               
               
                 19 
                 IPI00172656 
                 ETEA 
                 FAF2 
               
               
                 20 
                 IPI00554723 
                 DXS648E 
                 RPL10P15 
               
               
                 21 
                 IPI00304925 
                 HSPA1 
                 HSPA1A 
               
               
                 22 
                 IPI00386755 
                 ERO1L 
                 ERO1L 
               
               
                 23 
                 IPI00985019 
                 RPL28 
               
               
                 24 
                 IPI00023640 
                 PDCD5 
                 PDCD5 
               
               
                 25 
                 IPI00418471 
                 VIM 
                 VIM 
               
               
                 26 
                 IPI00003438 
                 DNAJC8 
                 DNAJC8 
               
               
                 27 
                 IPI00414717 
                 CFR1 
                 GLG1 
               
               
                 28 
                 IPI00021828 
                 CST6 
                 Cstb 
               
               
                 29 
                 IPI00844578 
                 DDX9 
                 dhx9 
               
               
                 30 
                 IPI00749113 
                 DUT 
                 dut 
               
               
                 31 
                 IPI00607584 
                 MYBBP1A 
                 mybbp1a 
               
               
                 32 
                 IPI00021766 
                 KIAA0886 
                 rtn4 
               
               
                 33 
                 IPI00410177 
                 ENSA 
                 ENSA 
               
               
                 34 
                 IPI00220487 
                 ATP5H 
                 atp5h 
               
               
                 35 
                 IPI00007927 
                 CAPE 
                 SMC2 
               
               
                 36 
                 IPI00300341 
                 TCEB1 
                 LOC100132973 
               
               
                 37 
                 IPI00746655 
                 ESYT1 
                 Esyt1 
               
               
                 38 
                 IPI00017963 
                 SNRPD1 
                 LOC119358 
               
               
                 39 
                 IPI00007940 
                 C10orf69 
                 ERLIN1 
               
               
                 40 
                 IPI00013744 
                 CD49B 
                 ITGA2 
               
               
                 41 
                 IPI00219037 
                 H2AFX 
                 H2afx 
               
               
                 42 
                 IPI00000051 
                 PFD1 
                 PFDN1 
               
               
                 43 
                 IPI00220271 
                 AKR1A1 
                 AKR1A1 
               
               
                 44 
                 IPI00056494 
                 RPL36AL 
                 RPL36AL 
               
               
                 45 
                 IPI00220871 
                 RPL37 
                 RPL37 
               
               
                 46 
                 IPI00007764 
                 ARM2 
                 HN1 
               
               
                 47 
                 IPI00921118 
                 ACTN1 
                 actn1 
               
               
                 48 
                 IPI00910593 
                 CNN2 
                 CNN2 
               
               
                 49 
                 IPI00299024 
                 BASP1 
                 Basp1 
               
               
                 50 
                 IPI00914566 
                 FDPS 
                 FDPS 
               
               
                 51 
                 IPI00854642 
                 KIAA0648 
                 PDS5A 
               
               
                 52 
                 IPI00024095 
                 ANX3 
                 anxa3 
               
               
                 53 
                 IPI00005634 
                 KIAA0372 
                 TTC37 
               
               
                 54 
                 IPI00157790 
                 ECM29 
                 KIAA0368 
               
               
                 55 
                 IPI00026824 
                 HMOX2 
                 Hmox2 
               
               
                 56 
                 IPI00026670 
                 TCEB2 
                 Tceb2 
               
               
                 57 
                 IPI00219162 
                 RPL39 
                 RPL39P20 
               
               
                 58 
                 IPI00646762 
                 NUDT5 
                 NUDT5 
               
               
                 59 
                 IPI00456429 
                 UBA52 
                 uba52 
               
               
                 60 
                 IPI00465132 
                 COPE 
                 cope 
               
               
                 61 
                 IPI00289876 
                 STX7 
                 STX7 
               
               
                 62 
                 IPI00026942 
                 C8orf2 
                 Erlin2 
               
               
                 63 
                 IPI00011916 
                 AIMP2 
                 STAG3L3 
               
               
                 64 
                 IPI00299524 
                 CAPD2 
                 NCAPD2 
               
               
                 65 
                 IPI00032830 
                 CGI-114 
                 Rexo2 
               
               
                 66 
                 IPI00010720 
                 CCT5 
                 cct5 
               
               
                 67 
                 IPI00556451 
                 ETFB 
                 etfB 
               
               
                 68 
                 IPI00938079 
                 DRIP4 
                 PDCD6IP 
               
               
                 69 
                 IPI00719752 
                 EIF3B 
                 EIF3B 
               
               
                 70 
                 IPI00002214 
                 KPNA2 
                 KPNA2 
               
               
                 71 
                 IPI00329692 
                 NMT 
                 NMT1 
               
               
                 72 
                 IPI00011126 
                 PSMC1 
                 psmc1 
               
               
                 73 
                 IPI00216951 
                 DARS 
                 Dars 
               
               
                 74 
                 IPI00761160 
                 CAST 
                 cast 
               
               
                 75 
                 IPI00219005 
                 FKBP4 
                 fkbp4 
               
               
                 76 
                 IPI00295400 
                 IFI53 
                 wars 
               
               
                 77 
                 IPI00924788 
                 AADACL1 
                 NCEH1 
               
               
                 78 
                 IPI00046828 
                 CCDC58 
                 Ccdc58 
               
               
                 79 
                 IPI00219526 
                 PGM1 
                 pgm1 
               
               
                 80 
                 IPI00014589 
                 CLTB 
                 Cltb 
               
               
                 81 
                 IPI00006052 
                 HSPC231 
                 PFDN2 
               
               
                 82 
                 IPI00375631 
                 G1P2 
                 ISG15 
               
               
                 83 
                 IPI00305692 
                 TRP32 
                 txnl1 
               
               
                 84 
                 IPI00328319 
                 RBAP48 
                 LOC642954 
               
               
                 85 
                 IPI00008380 
                 PPP2CA 
                 PPP2CA 
               
               
                 86 
                 IPI00983296 
                 ACLY variant protein 
               
               
                 87 
                 IPI01013296 
                 FER1L3 
               
               
                 88 
                 IPI00015029 
                 P23 
                 Ptges3 
               
               
                 89 
                 IPI00015911 
                 DLD 
                 dld 
               
               
                 90 
                 IPI00013683 
                 TUBB3 
                 MC1R 
               
               
                 91 
                 IPI01010055 
                 ANX11 
               
               
                 92 
                 IPI00644386 
                 FUBP1 
                 FUBP1 
               
               
                 93 
                 IPI00798071 
                 NAP1L4 
                 nap1l4 
               
               
                 94 
                 IPI00100796 
                 C9orf83 
                 Chmp5 
               
               
                 95 
                 IPI00016862 
                 GLUR 
                 gsr 
               
               
                 96 
                 IPI00470649 
                 NCLN 
                 ncln 
               
               
                 97 
                 IPI00295542 
                 NUC 
                 NUCB1 
               
               
                 98 
                 IPI00030131 
                 LAP2 
                 TMPO 
               
               
                 99 
                 IPI00024403 
                 CPN3 
                 CPNE3 
               
               
                 100 
                 IPI00014938 
                 HCC1 
                 SARNP 
               
               
                 101 
                 IPI00069750 
                 FIR 
                 PUF60 
               
               
                 102 
                 IPI00031420 
                 UGDH 
                 UGDH 
               
               
                 103 
                 IPI00646839 
                 EIF3CL 
                 EIF3CL 
               
               
                 104 
                 IPI00013290 
                 HDGF2 
                 Hdgfrp2 
               
               
                 105 
                 IPI00646350 
                 NAE1 
                 Nae1 
               
               
                 106 
                 IPI00215998 
                 CD63 
                 CD63 
               
               
                 107 
                 IPI00010706 
                 GSS 
                 gss 
               
               
                 108 
                 IPI00218775 
                 AIG6 
                 FKBP5 
               
               
                 109 
                 IPI00218343 
                 TUBA1C 
                 TUBA1C 
               
               
                 110 
                 IPI00783097 
                 GARS 
                 Gars 
               
               
                 111 
                 IPI00012268 
                 PSMD2 
                 PSMD2 
               
               
                 112 
                 IPI00027350 
                 NKEFB 
                 PRDX2 
               
               
                 113 
                 IPI00306382 
                 C1orf3 
                 Scamp3 
               
               
                 114 
                 IPI00026625 
                 KIAA0791 
                 NUP155 
               
               
                 115 
                 IPI00300371 
                 KIAA0017 
                 sf3b3 
               
               
                 116 
                 IPI00220739 
                 HPR6.6 
                 PGRMC1 
               
               
                 117 
                 IPI00329633 
                 TARS 
                 Tars 
               
               
                 118 
                 IPI00828189 
                 PCMT1 
                 pcmt1 
               
               
                 119 
                 IPI00002966 
                 APG2 
                 HSPA4 
               
               
                 120 
                 IPI00004860 
                 RARS 
                 rars 
               
               
                 121 
                 IPI00021785 
                 COX5B 
                 COX5B 
               
               
                 122 
                 IPI00396435 
                 DBP1 
                 DHX15 
               
               
                 123 
                 IPI00220834 
                 G22P2 
                 XRCC5 
               
               
                 124 
                 IPI00219097 
                 HMG2 
                 HMGB2 
               
               
                 125 
                 IPI00017367 
                 hCG_39182 
                 rdx 
               
               
                 126 
                 IPI00007001 
                 CGI-113 
                 mrpl11 
               
               
                 127 
                 IPI00658000 
                 IGF2BP3 
                 igf2bp3 
               
               
                 128 
                 IPI00007074 
                 YARS 
                 Yars 
               
               
                 129 
                 IPI00007188 
                 ANT2 
                 SLC25A5 
               
               
                 130 
                 IPI00306369 
                 NSUN2 
                 nsun2 
               
               
                 131 
                 IPI00009922 
                 C14orf156 
                 C14orf156 
               
               
                 132 
                 IPI00298520 
                 ARCN1 
                 Arcn1 
               
               
                 133 
                 IPI00215637 
                 DBX 
                 DDX3X 
               
               
                 134 
                 IPI00916503 
                 BZAP45 
                 BZW1 
               
               
                 135 
                 IPI00402183 
                 HNRPQ 
                 SYNCRIP 
               
               
                 136 
                 IPI00383581 
                 G2AN 
                 GANAB 
               
               
                 137 
                 IPI00166010 
                 AD-005 
                 cnot1 
               
               
                 138 
                 IPI00030275 
                 HSP75 
                 Trap1 
               
               
                 139 
                 IPI00062120 
                 AAG13 
                 S100a16 
               
               
                 140 
                 IPI00006482 
                 ATP1A1 
                 ATP1A1 
               
               
                 141 
                 IPI00012007 
                 AHCY 
                 ahcY 
               
               
                 142 
                 IPI00027230 
                 GRP94 
                 Hsp90b1 
               
               
                 143 
                 IPI00794900 
                 MTHFC 
                 mthfd1 
               
               
                 144 
                 IPI00156689 
                 VAT1 
                 vat1 
               
               
                 145 
                 IPI00215901 
                 ADK2 
                 Ak2 
               
               
                 146 
                 IPI00220219 
                 COPB2 
                 copb2 
               
               
                 147 
                 IPI00217477 
                 HMG2A 
                 HMGB3 
               
               
                 148 
                 IPI00783982 
                 COPG 
                 CopG 
               
               
                 149 
                 IPI00746777 
                 ADH5 
                 ADH5 
               
               
                 150 
                 IPI00644712 
                 G22P1 
                 LOC389901 
               
               
                 151 
                 IPI00006211 
                 UNQ484/PRO983 
                 vapB 
               
               
                 152 
                 IPI00884105 
                 LAMP1 
                 lamp1 
               
               
                 153 
                 IPI00654777 
                 hCG_1784554 
                 LOC390282 
               
               
                 154 
                 IPI00909484 
                 CDC42 
               
               
                 155 
                 IPI00026216 
                 NPEPPS 
                 npepps 
               
               
                 156 
                 IPI00009790 
                 PFKF 
                 pfkp 
               
               
                 157 
                 IPI00029079 
                 GMPS 
                 GMPS 
               
               
                 158 
                 IPI00004534 
                 KIAA0361 
                 PFAS 
               
               
                 159 
                 IPI00295851 
                 COPB 
                 COPB1 
               
               
                 160 
                 IPI00291922 
                 PSMA5 
                 psma5 
               
               
                 161 
                 IPI00024175 
                 HSPC 
                 PSMA7 
               
               
                 162 
                 IPI00031522 
                 HADH 
                 HADHA 
               
               
                 163 
                 IPI00013847 
                 UQCRC1 
                 Uqcrc1 
               
               
                 164 
                 IPI00219525 
                 PGD 
                 PGD 
               
               
                 165 
                 IPI00930710 
                 hCG_40633 
                 SLC25A13 
               
               
                 166 
                 IPI00296337 
                 HYRC 
                 PRKDC 
               
               
                 167 
                 IPI00165261 
                 C14orf163 
                 SCFD1 
               
               
                 168 
                 IPI00790305 
                 PCNP 
               
               
                 169 
                 IPI00218782 
                 CAPZB 
                 CAPZB 
               
               
                 170 
                 IPI00784366 
                 ADTB2 
                 AP2B1 
               
               
                 171 
                 IPI00453473 
                 H4/A 
                 Hist1h4c 
               
               
                 172 
                 IPI00796366 
                 MYL6 
                 myl6 
               
               
                 173 
                 IPI00032003 
                 EDMD 
                 emd 
               
               
                 174 
                 IPI00102069 
                 EIF3M 
                 EIF3M 
               
               
                 175 
                 IPI00418497 
                 PRO1512 
                 timm50 
               
               
                 176 
                 IPI00019755 
                 GSTO1 
                 GSTO1 
               
               
                 177 
                 IPI00016179 
                 S100A13 
                 S100A13 
               
               
                 178 
                 IPI00005719 
                 RAB1 
                 RAB1A 
               
               
                 179 
                 IPI00215965 
                 HNRNPA1 
                 LOC644037 
               
               
                 180 
                 IPI00382452 
                 CHMP1 
                 Chmp1a 
               
               
                 181 
                 IPI00025273 
                 GART 
                 GART 
               
               
                 182 
                 IPI00014587 
                 CLTA 
                 CLTA 
               
               
                 183 
                 IPI00183695 
                 ANX2LG 
                 S100A10 
               
               
                 184 
                 IPI00401264 
                 ERP44 
                 ERP44 
               
               
                 185 
                 IPI00514399 
                 RP11-422P24.3-002 
                 RPS27P13 
               
               
                 186 
                 IPI00472442 
                 HC2 
                 PSMA1 
               
               
                 187 
                 IPI00815642 
                 TMSB4X 
                 TMSL1 
               
               
                 188 
                 IPI00647286 
                 C9orf88 
                 Fam129b 
               
               
                 189 
                 IPI00026087 
                 BAF 
                 LOC645870 
               
               
                 190 
                 IPI00007755 
                 KIAA0118 
                 rab21 
               
               
                 191 
                 IPI00022977 
                 CKB 
                 CKB 
               
               
                 192 
                 IPI00218568 
                 DCOH 
                 Pcbd1 
               
               
                 193 
                 IPI01024911 
                 PROS27 
               
               
                 194 
                 IPI00027341 
                 AFCP 
                 capG 
               
               
                 195 
                 IPI00945633 
                 SSR1 
                 SSR1 
               
               
                 196 
                 IPI00005657 
                 HKE2 
                 pfdn6 
               
               
                 197 
                 IPI00290461 
                 EIF3J 
                 EIF3J 
               
               
                 198 
                 IPI00299155 
                 HC9 
                 Psma4 
               
               
                 199 
                 IPI00219034 
                 NDUFA8 
                 Ndufa8 
               
               
                 200 
                 IPI00026268 
                 GNB1 
                 GNB1 
               
               
                 201 
                 IPI00032561 
                 CAB39 
                 cab39 
               
               
                 202 
                 IPI00006378 
                 CCDC72 
               
               
                 203 
                 IPI00026964 
                 UQCRFS1 
                 uqcrfs1 
               
               
                 204 
                 IPI00396563 
                 SAKS1 
                 Ubxn1 
               
               
                 205 
                 IPI00023542 
                 GP25L2 
                 tmed9 
               
               
                 206 
                 IPI00008485 
                 ACO1 
                 ACO1 
               
               
                 207 
                 IPI00293126 
                 CG22 
                 TBCB 
               
               
                 208 
                 IPI00943181 
                 PSME2 
                 PSME2 
               
               
                 209 
                 IPI00220344 
                 GIG15 
               
               
                 210 
                 IPI00013068 
                 EIF3E 
                 Eif3e 
               
               
                 211 
                 IPI00029631 
                 ERH 
                 ERH 
               
               
                 212 
                 IPI00292771 
                 NUMA 
                 NUMA1 
               
               
                 213 
                 IPI00009960 
                 HMP 
                 IMMT 
               
               
                 214 
                 IPI00384265 
                 C9orf10 
                 FAM120A 
               
               
                 215 
                 IPI00477313 
                 HNRNPC 
                 Hnrnpc 
               
               
                 216 
                 IPI00413778 
                 FKBP1 
                 FKBP1A 
               
               
                 217 
                 IPI00942869 
                 CTNND1 
                 CTNND1 
               
               
                 218 
                 IPI00017964 
                 SNRPD3 
                 snrpd3 
               
               
                 219 
                 IPI00219029 
                 GOT1 
                 GOT1 
               
               
                 220 
                 IPI00420084 
                 BID 
                 BID 
               
               
                 221 
                 IPI00011603 
                 PSMD3 
                 psmd3 
               
               
                 222 
                 IPI00031109 
                 NDUFA12L 
                 NDUFAF2 
               
               
                 223 
                 IPI01022656 
                 DDX17 
               
               
                 224 
                 IPI00299977 
                 CGI-202 
                 Phpt1 
               
               
                 225 
                 IPI00009225 
                 STX8 
                 Stx8 
               
               
                 226 
                 IPI00554681 
                 NDUFA5 
                 NDUFA5 
               
               
                 227 
                 IPI00009407 
                 DAD1 
                 DAD1 
               
               
                 228 
                 IPI00217466 
                 H1F3 
                 Hist1h1d 
               
               
                 229 
                 IPI00011604 
                 GCSH 
                 LOC654085 
               
               
                 230 
                 IPI00301434 
                 BOLA2 
                 bolA2 
               
               
                 231 
                 IPI01015908 
                 DCTN2 
               
               
                 232 
                 IPI00399089 
                 KIAA0081 
                 MESDC2 
               
               
                 233 
                 IPI00947070 
                 RPL22L1 
                 RPL22L1 
               
               
                 234 
                 IPI00290738 
                 CALM 
                 PICALM 
               
               
                 235 
                 IPI00413641 
                 AKR1B1 
                 AKR1B1 
               
               
                 236 
                 IPI00176903 
                 FKSG13 
                 PTRF 
               
               
                 237 
                 IPI00291783 
                 GEMIN5 
                 GEMIN5 
               
               
                 238 
                 IPI00936125 
                 DIAP1 
                 DIAPH1 
               
               
                 239 
                 IPI00032140 
                 CBP1 
                 SERPINH1 
               
               
                 240 
                 IPI00385042 
                 CRFG 
                 GTPBP4 
               
               
                 241 
                 IPI00172594 
                 MAAT1 
                 mrpl28 
               
               
                 242 
                 IPI00473136 
                 CTNNA1 
                 Ctnna1 
               
               
                 243 
                 IPI00478410 
                 ATP5C 
                 Atp5c1 
               
               
                 244 
                 IPI00830136 
                 C1orf31 
                 C1orf31 
               
               
                 245 
                 IPI00305092 
                 PYM 
                 wibg 
               
               
                 246 
                 IPI00220528 
                 PBSCF 
                 SNRPF 
               
               
                 247 
                 IPI00216682 
                 CNN3 
                 cnn3 
               
               
                 248 
                 IPI00002535 
                 FKBP13 
                 Fkbp2 
               
               
                 249 
                 IPI00009253 
                 NAPA 
                 napA 
               
               
                 250 
                 IPI00000105 
                 LRP 
                 MVP 
               
               
                 251 
                 IPI00883655 
                 DPYSL2 
                 Dpysl2 
               
               
                 252 
                 IPI00295857 
                 COPA 
                 copA 
               
               
                 253 
                 IPI00004406 
                 UP 
                 upp1 
               
               
                 254 
                 IPI00328905 
                 IQGAP3 
                 Iqgap3 
               
               
                 255 
                 IPI00291607 
                 ITPR3 
                 ITPR3 
               
               
                 256 
                 IPI00031397 
                 ACS3 
                 ACSL3 
               
               
                 257 
                 IPI00215997 
                 CD9 
                 CD9 
               
               
                 258 
                 IPI00924816 
                 MTPN 
                 mtpn 
               
               
                 259 
                 IPI00010779 
                 TPM4 
                 TPM4 
               
               
                 260 
                 IPI00292657 
                 LTB4DH 
                 PTGR1 
               
               
                 261 
                 IPI00456008 
                 ATP5A 
                 Atp5j 
               
               
                 262 
                 IPI00014149 
                 KIAA0103 
                 ttc35 
               
               
                 263 
                 IPI00411559 
                 CAPC 
                 SMC4 
               
               
                 264 
                 IPI00220014 
                 IDI1 
                 IDI1 
               
               
                 265 
                 IPI00030911 
                 VAMP8 
                 Vamp8 
               
               
                 266 
                 IPI00396015 
                 ACAC 
                 ACACA 
               
               
                 267 
                 IPI00037448 
                 GLXR 
                 grhpr 
               
               
                 268 
                 IPI00020944 
                 FDFT1 
                 FDFT1 
               
               
                 269 
                 IPI00913848 
                 FERMT2 
                 Fermt2 
               
               
                 270 
                 IPI00333215 
                 GTF2S 
                 TCEA1P2 
               
               
                 271 
                 IPI00871174 
                 AMY1 
                 MYCBP 
               
               
                 272 
                 IPI00215777 
                 OK/SW-cl.48 
                 SLC25A3 
               
               
                 273 
                 IPI00797738 
                 COX6B 
                 COX6B1 
               
               
                 274 
                 IPI00027681 
                 NNMT 
                 nnmt 
               
               
                 275 
                 IPI00024670 
                 C5orf18 
                 REEP5 
               
               
                 276 
                 IPI00009236 
                 CAV 
                 cav1 
               
               
                 277 
                 IPI00219825 
                 GLBA 
                 PSAP 
               
               
                 278 
                 IPI00011631 
                 ZW10 
                 ZW10 
               
               
                 279 
                 IPI00554788 
                 CYK18 
                 KRT18P19 
               
               
                 280 
                 IPI00001734 
                 PSA 
                 C8orf62 
               
               
                 281 
                 IPI00011284 
                 COMT 
                 COMT 
               
               
                 282 
                 IPI00001589 
                 TIM13B 
                 Timm13 
               
               
                 283 
                 IPI00019869 
                 S100A2 
                 S100A2 
               
               
                 284 
                 IPI00002134 
                 KIAA0072 
                 PSMD5 
               
               
                 285 
                 IPI00004838 
                 CRK 
                 crk 
               
               
                 286 
                 IPI00031410 
                 FRAP 
                 MTOR 
               
               
                 287 
                 IPI00783781 
                 C7orf14 
                 NUP205 
               
               
                 288 
                 IPI00009634 
                 CGI-44 
                 SQRDL 
               
               
                 289 
                 IPI00893715 
                 EPCAM 
                 epcam 
               
               
                 290 
                 IPI00010346 
                 AGTBP 
                 NLN 
               
               
                 291 
                 IPI00329696 
                 CGI-90 
                 Fam82b 
               
               
                 292 
                 IPI00016925 
                 C10 
                 C12orf57 
               
               
                 293 
                 IPI00289758 
                 CANPL2 
                 CAPN2 
               
               
                 294 
                 IPI00011635 
                 BCL2L13 
                 BCL2L13 
               
               
                 295 
                 IPI00966114 
                 SMN 
               
               
                 296 
                 IPI01025459 
                 HE1 
               
               
                 297 
                 IPI01021644 
                 RAB5C 
               
               
                 298 
                 IPI00027442 
                 AARS 
                 AARS 
               
               
                 299 
                 IPI00014238 
                 KARS 
                 KARS 
               
               
                 300 
                 IPI00465315 
                 CYC 
                 CYCS 
               
               
                 301 
                 IPI00550069 
                 PRI 
                 rnh1 
               
               
                 302 
                 IPI00003527 
                 NHERF 
                 SLC9A3R1 
               
               
                 303 
                 IPI00027223 
                 IDH1 
                 IDH1 
               
               
                 304 
                 IPI00031526 
                 C19orf43 
                 c19orf43 
               
               
                 305 
                 IPI00293434 
                 SRP14 
                 SRP14 
               
               
                 306 
                 IPI00166865 
                 CDGSH2 
                 cisd2 
               
               
                 307 
                 IPI00021347 
                 UBCE7 
                 ube2l3 
               
               
                 308 
                 IPI00030320 
                 DDX6 
                 DDX6 
               
               
                 309 
                 IPI00294536 
                 MAWD 
                 strap 
               
               
                 310 
                 IPI00021728 
                 EIF2B 
                 Eif2s2 
               
               
                 311 
                 IPI00429191 
                 ERF1 
                 etf1 
               
               
                 312 
                 IPI00005198 
                 ILF2 
                 ilf2 
               
               
                 313 
                 IPI00514587 
                 RP11-352P4.2-004 
                 SARS 
               
               
                 314 
                 IPI00916847 
                 GTPBP9 
                 Ola1 
               
               
                 315 
                 IPI00374657 
                 VAP33 
                 vapa 
               
               
                 316 
                 IPI00010080 
                 KIAA1101 
                 OXSR1 
               
               
                 317 
                 IPI00009104 
                 CGI-46 
                 RUVBL2 
               
               
                 318 
                 IPI00790739 
                 ACO2 
                 ACO2 
               
               
                 319 
                 IPI00878984 
                 DDT 
                 ddt 
               
               
                 320 
                 IPI00019407 
                 H105E3 
                 nsdhl 
               
               
                 321 
                 IPI00025019 
                 PSC5 
                 psmb1 
               
               
                 322 
                 IPI00910781 
                 GPI 
                 GPI 
               
               
                 323 
                 IPI00420108 
                 DLST 
                 DLST 
               
               
                 324 
                 IPI00785113 
                 GCF2 
                 Lrrfip1 
               
               
                 325 
                 IPI00009368 
                 SFXN1 
                 SFXN1 
               
               
                 326 
                 IPI00017184 
                 CDABP0131 
                 EHD1 
               
               
                 327 
                 IPI00008418 
                 DIABLO 
                 Diablo 
               
               
                 328 
                 IPI00024719 
                 HAT1 
                 HAT1 
               
               
                 329 
                 IPI00646556 
                 NDUFV2 
                 Ndufv2 
               
               
                 330 
                 IPI00026516 
                 OXCT 
                 oxct1 
               
               
                 331 
                 IPI00783313 
                 PYGL 
                 PYGL 
               
               
                 332 
                 IPI00550451 
                 PPP1A 
                 Ppp1ca 
               
               
                 333 
                 IPI00219861 
                 ACP1 
                 acp1 
               
               
                 334 
                 IPI00004358 
                 PYGB 
                 pygb 
               
               
                 335 
                 IPI00418262 
                 ALDC 
                 aldoc 
               
               
                 336 
                 IPI00220059 
                 NDUFB4 
                 LOC402175 
               
               
                 337 
                 IPI00023001 
                 C3orf28 
                 Fam162a 
               
               
                 338 
                 IPI00032406 
                 CPR3 
                 Dnaja2 
               
               
                 339 
                 IPI00397904 
                 KIAA0095 
                 NUP93 
               
               
                 340 
                 IPI00926977 
                 PSMC6 
                 Psmc6 
               
               
                 341 
                 IPI00103142 
                 NUDCD2 
                 NUDCD2 
               
               
                 342 
                 IPI00005537 
                 MRPL12 
               
               
                 343 
                 IPI00939163 
                 HSP105 
                 HSPH1 
               
               
                 344 
                 IPI00031820 
                 FARS 
                 farsa 
               
               
                 345 
                 IPI00414384 
                 C9orf99 
                 hsdl2 
               
               
                 346 
                 IPI00386119 
                 SF1 
                 Sf1 
               
               
                 347 
                 IPI00025974 
                 C20orf178 
                 CHMP4B 
               
               
                 348 
                 IPI00003627 
                 ACTL6A 
                 actl6a 
               
               
                 349 
                 IPI00012578 
                 KPNA4 
                 KPNA4 
               
               
                 350 
                 IPI00006213 
                 PCM1 
                 pcm1 
               
               
                 351 
                 IPI00375380 
                 PSMD13 
                 PSMD13 
               
               
                 352 
                 IPI00015972 
                 COX6C 
                 COX6C 
               
               
                 353 
                 IPI00555917 
                 PXN 
                 PXN 
               
               
                 354 
                 IPI00956559 
                 EIF4G1 
               
               
                 355 
                 IPI00027175 
                 SRI 
                 SRI 
               
               
                 356 
                 IPI00939707 
                 KIAA0664 
                 kiaa0664 
               
               
                 357 
                 IPI00006658 
                 PIN4 
                 PIN4 
               
               
                 358 
                 IPI00015953 
                 DDX21 
                 DDX21 
               
               
                 359 
                 IPI00719040 
                 C1orf77 
                 c1orf77 
               
               
                 360 
                 IPI00018120 
                 DAP3 
                 DAP3 
               
               
                 361 
                 IPI00005038 
                 HRSP12 
                 Hrsp12 
               
               
                 362 
                 IPI00000861 
                 LASP1 
                 LASP1 
               
               
                 363 
                 IPI00332499 
                 NASP 
                 NASP 
               
               
                 364 
                 IPI00255052 
                 LYRM3 
                 NDUFB9 
               
               
                 365 
                 IPI00019600 
                 MMS2 
                 ube2v2 
               
               
                 366 
                 IPI00185374 
                 PSMD12 
                 PSMD12 
               
               
                 367 
                 IPI00640197 
                 RP11-29B2.2-002 
                 tpp2 
               
               
                 368 
                 IPI00033143 
                 ARG134 
                 EIF3K 
               
               
                 369 
                 IPI00025318 
                 SH3BGRL 
                 SH3BGRL 
               
               
                 370 
                 IPI00219381 
                 NDUFA2 
                 Ndufa2 
               
               
                 371 
                 IPI00008164 
                 PEP 
                 prep 
               
               
                 372 
                 IPI00419237 
                 LAP3 
                 LAP3 
               
               
                 373 
                 IPI00921422 
                 CKAP5 
                 ckap5 
               
               
                 374 
                 IPI00303954 
                 CYB5B 
                 CYB5B 
               
               
                 375 
                 IPI00220416 
                 UQBP 
                 LOC442454 
               
               
                 376 
                 IPI00941534 
                 CDC10 
                 41159 
               
               
                 377 
                 IPI00005966 
                 DAP13 
                 NDUFA12 
               
               
                 378 
                 IPI00299608 
                 PSMD1 
                 PSMD1 
               
               
                 379 
                 IPI00024742 
                 UQCRQ 
                 UQCRQ 
               
               
                 380 
                 IPI00063903 
                 HCVFTP2 
                 USMG5 
               
               
                 381 
                 IPI00000335 
                 HINT2 
                 HINT2 
               
               
                 382 
                 IPI00855767 
                 RAP1GDS1 
                 Rap1gds1 
               
               
                 383 
                 IPI00016703 
                 DHCR24 
                 DHCR24 
               
               
                 384 
                 IPI00790503 
                 MYH10 
                 myh10 
               
               
                 385 
                 IPI00024781 
                 FAM2C 
                 SERF2 
               
               
                 386 
                 IPI00414289 
                 COPS1 
                 GPS1 
               
               
                 387 
                 IPI00073779 
                 HDCMD11P 
                 MRPS35 
               
               
                 388 
                 IPI00022694 
                 MCB1 
                 PSMD4 
               
               
                 389 
                 IPI00004839 
                 CRKL 
                 CRKL 
               
               
                 390 
                 IPI00217553 
                 BMRP 
                 mRpL41 
               
               
                 391 
                 IPI00294242 
                 IMOGN38 
                 mRpS31 
               
               
                 392 
                 IPI00022276 
                 HSPC007 
                 mRpS28 
               
               
                 393 
                 IPI00216138 
                 SM22 
                 TAGLN 
               
               
                 394 
                 IPI00012535 
                 DNAJ2 
                 Dnaja1 
               
               
                 395 
                 IPI00020510 
                 C10orf70 
                 CISD1 
               
               
                 396 
                 IPI00005107 
                 NPC1 
                 npc1 
               
               
                 397 
                 IPI00333763 
                 C14orf87 
                 glrx5 
               
               
                 398 
                 IPI00001458 
                 KIAA0166 
                 KNTC1 
               
               
                 399 
                 IPI00009901 
                 NTF2 
                 NUTF2 
               
               
                 400 
                 IPI00010136 
                 CTBP2 
                 CTBP2 
               
               
                 401 
                 IPI00747849 
                 ATP1B 
                 Atp1b1 
               
               
                 402 
                 IPI00220063 
                 NDUFS5 
                 Ndufs5 
               
               
                 403 
                 IPI00178352 
                 ABPL 
                 FLNC 
               
               
                 404 
                 IPI00017292 
                 CTNNB 
                 CTNNB1 
               
               
                 405 
                 IPI00022442 
                 NDUFAB1 
                 NDUFAB1 
               
               
                 406 
                 IPI00935906 
                 DCTN1 
                 DCTN1 
               
               
                 407 
                 IPI00294501 
                 D7SR 
                 DHCR7 
               
               
                 408 
                 IPI00031023 
                 FLIl 
                 flil 
               
               
                 409 
                 IPI00297910 
                 GA733-1 
                 TACSTD2 
               
               
                 410 
                 IPI00747764 
                 IPOA7 
                 KPNA6 
               
               
                 411 
                 IPI00006863 
                 SPAG7 
                 SPAG7 
               
               
                 412 
                 IPI00909064 
                 COASY 
                 COASY 
               
               
                 413 
                 IPI00001541 
                 TIM9 
                 TIMM9 
               
               
                 414 
                 IPI00025285 
                 ATP6G 
                 ATP6V1G1 
               
               
                 415 
                 IPI00002186 
                 ARFGEF2 
                 ARFGEF2 
               
               
                 416 
                 IPI00743335 
                 MYO1C 
                 Myo1C 
               
               
                 417 
                 IPI00298111 
                 SNX6 
                 snx6 
               
               
                 418 
                 IPI00005087 
                 TMOD3 
                 tmod3 
               
               
                 419 
                 IPI00025725 
                 NDUFB1 
                 NDUFB1 
               
               
                 420 
                 IPI00294578 
                 TGM2 
                 tgm2 
               
               
                 421 
                 IPI00219604 
                 MAP2K1 
                 MAP2K1 
               
               
                 422 
                 IPI00022334 
                 OAT 
                 OAT 
               
               
                 423 
                 IPI00026833 
                 ADSS 
                 ADSS 
               
               
                 424 
                 IPI00291419 
                 ACAT2 
                 Acat2 
               
               
                 425 
                 IPI00333913 
                 NAG 
                 NBAS 
               
               
                 426 
                 IPI00016046 
                 C20orf52 
                 ROMO1 
               
               
                 427 
                 IPI00909465 
                 CDA016 
                 Yjefn3 
               
               
                 428 
                 IPI00397358 
                 MPS1 
                 RPS27P13 
               
               
                 429 
                 IPI00029266 
                 SNRPE 
                 LOC100130109 
               
               
                 430 
                 IPI00001661 
                 CHC1 
                 SNHG3-RCC1 
               
               
                 431 
                 IPI00742124 
                 KIAA0794 
                 UBXN7 
               
               
                 432 
                 IPI00043598 
                 IKBIP 
                 ikbip 
               
               
                 433 
                 IPI00220573 
                 MLCB 
                 MYL12A 
               
               
                 434 
                 IPI00797136 
                 IKBIP 
                 ikbip 
               
               
                 435 
                 IPI00010214 
                 S100A14 
                 S100A14 
               
               
                 436 
                 IPI00061531 
                 MRPL53 
                 MRPL53 
               
               
                 437 
                 IPI00059242 
                 PRO3113 
                 Syap1 
               
               
                 438 
                 IPI00339384 
                 ARSDR1 
                 rdh11 
               
               
                 439 
                 IPI00020495 
                 DC47 
                 mrps36 
               
               
                 440 
                 IPI00296022 
                 UQCRH 
                 Uqcrh 
               
               
                 441 
                 IPI00022277 
                 CCDC56 
                 Ccdc56 
               
               
                 442 
                 IPI00027448 
                 ATP5L 
                 atp5l 
               
               
                 443 
                 IPI00166483 
                 C17orf61 
                 C17orf61 
               
               
                 444 
                 IPI00024920 
                 ATP5D 
                 Atp5d 
               
               
                 445 
                 IPI00015077 
                 EIF1 
                 LOC730144 
               
               
                 446 
                 IPI00166528 
                 KIAA1999 
                 RICTOR 
               
               
                 447 
                 IPI00101968 
                 CMAP 
                 DBNL 
               
               
                 448 
                 IPI00964886 
                 DDP2 
               
               
                 449 
                 IPI00020827 
                 hCG_40237 
               
               
                 450 
                 IPI01021606 
                 BAF170 
               
               
                 451 
                 IPI01025410 
                 ACYP1 
               
               
                 452 
                 IPI00968228 
                 DC2 
               
               
                 453 
                 IPI00955022 
                 TJP2 
               
               
                 454 
                 IPI00472416 
                 HLAB 
               
               
                 455 
                 IPI00554481 
                   
                 SLC3A2 
               
               
                 456 
                 IPI00021570 
                   
                 EDF1 
               
               
                 457 
                 IPI00008552 
                   
                 glrx3 
               
               
                 458 
                 IPI00289491 
                   
                 Casc3 
               
               
                 459 
                 IPI00465233 
                   
                 EIF3L 
               
               
                 460 
                 IPI00328748 
                   
                 manf 
               
               
                 461 
                 IPI01020803 
               
               
                 462 
                 IPI00473014 
                   
                 DSTN 
               
               
                 463 
                 IPI00017469 
                   
                 spr 
               
               
                 464 
                 IPI00015602 
                   
                 TOMM70A 
               
               
                 465 
                 IPI00033494 
                   
                 MYL12B 
               
               
                 466 
                 IPI00017726 
                   
                 HSD17B10 
               
               
                 467 
                 IPI00010141 
                   
                 POLE3 
               
               
                 468 
                 IPI00016513 
                   
                 RAB10 
               
               
                 469 
                 IPI00017510 
                   
                 COX2 
               
               
                 470 
                 IPI00026689 
                   
                 Cdk1 
               
               
                 471 
                 IPI00010414 
                   
                 PDLIM1 
               
               
                 472 
                 IPI00061525 
                   
                 Gnpnat1 
               
               
                 473 
                 IPI00022597 
                   
                 UBE2MP1 
               
               
                 474 
                 IPI00008964 
                   
                 RAB1B 
               
               
                 475 
                 IPI00031169 
                   
                 RAB2A 
               
               
                 476 
                 IPI00219445 
                   
                 PSME3 
               
               
                 477 
                 IPI00024919 
                   
                 prdx3 
               
               
                 478 
                 IPI00003588 
                   
                 EEF1E1 
               
               
                 479 
                 IPI00260715 
                   
                 fus 
               
               
                 480 
                 IPI00009032 
                   
                 ssb 
               
               
                 481 
                 IPI00028888 
                   
                 HNRNPD 
               
               
                 482 
                 IPI00894409 
                   
                 Rbm12 
               
               
                 483 
                 IPI00006980 
                   
                 c14orf166 
               
               
                 484 
                 IPI00179953 
                   
                 NASP 
               
               
                 485 
                 IPI00021370 
                   
                 UBE2K 
               
               
                 486 
                 IPI00028055 
                   
                 tmed10 
               
               
                 487 
                 IPI00029264 
                   
                 cyc1 
               
               
                 488 
                 IPI00450472 
                   
                 UBE2I 
               
               
                 489 
                 IPI00479262 
                   
                 Eif4g1 
               
               
                 490 
                 IPI00420014 
                   
                 SNRNP200 
               
               
                 491 
                 IPI00220031 
                   
                 PXN 
               
               
                 492 
                 IPI00012545 
                   
                 TGOLN2 
               
               
                 493 
                 IPI00301311 
                   
                 set 
               
               
                 494 
                 IPI00015952 
                   
                 EIF4G2 
               
               
                 495 
                 IPI00004962 
                   
                 Golim4 
               
               
                 496 
                 IPI00170692 
                   
                 vapa 
               
               
                 497 
                 IPI00018235 
                   
                 pef1 
               
               
                 498 
                 IPI00465432 
                   
                 nomo3 
               
               
                 499 
                 IPI00470779 
                   
                 TXLNA 
               
               
                 500 
                 IPI00549672 
                   
                 PSMD13 
               
               
                 501 
                 IPI00382733 
                   
                 Lrrfip1 
               
               
                 502 
                 IPI00027497 
                   
                 GPI 
               
               
                 503 
                 IPI00026111 
                   
                 tmco1 
               
               
                 504 
                 IPI00554521 
                   
                 FTHL3 
               
               
                 505 
                 IPI00397645 
                   
                 mxra7 
               
               
                 506 
                 IPI00974176 
               
               
                 507 
                 IPI00020127 
                   
                 RPA1 
               
               
                 508 
                 IPI00306516 
                   
                 Timm44 
               
               
                 509 
                 IPI00032881 
                   
                 MRPS23 
               
               
                 510 
                 IPI00449049 
                   
                 parp1 
               
               
                 511 
                 IPI00024642 
                   
                 Ccdc47 
               
               
                 512 
                 IPI00797384 
                   
                 Larp4 
               
               
                 513 
                 IPI00295098 
                   
                 srprb 
               
               
                 514 
                 IPI00413344 
                   
                 Cfl2 
               
               
                 515 
                 IPI00217223 
                   
                 paics 
               
               
                 516 
                 IPI00022202 
                   
                 SLC25A3 
               
               
                 517 
                 IPI00412987 
                   
                 gmfb 
               
               
                 518 
                 IPI00641181 
                   
                 MARCKSL1 
               
               
                 519 
                 IPI00017160 
                   
                 vta1 
               
               
                 520 
                 IPI00015361 
                   
                 PFDN5 
               
               
                 521 
                 IPI00030706 
                   
                 AHSA1 
               
               
                 522 
                 IPI00024976 
                   
                 Tomm22 
               
               
                 523 
                 IPI00646493 
                   
                 copA 
               
               
                 524 
                 IPI00216088 
                   
                 crabp2 
               
               
                 525 
                 IPI00744851 
                   
                 LOC100130009 
               
               
                 526 
                 IPI00871851 
                   
                 41154 
               
               
                 527 
                 IPI00024661 
                   
                 SEC24C 
               
               
                 528 
                 IPI00216592 
                   
                 Hnrnpc 
               
               
                 529 
                 IPI00024097 
                   
                 tes 
               
               
                 530 
                 IPI00247871 
                   
                 tcerg1 
               
               
                 531 
                 IPI00007935 
                   
                 PDLIM5 
               
               
                 532 
                 IPI00015842 
                   
                 RCN1 
               
               
                 533 
                 IPI00013723 
                   
                 PIN1 
               
               
                 534 
                 IPI00015102 
                   
                 Alcam 
               
               
                 535 
                 IPI00024871 
                   
                 Cbfb 
               
               
                 536 
                 IPI00019918 
                   
                 DDX19A 
               
               
                 537 
                 IPI00004968 
                   
                 prpf19 
               
               
                 538 
                 IPI00010860 
                   
                 Psmd9 
               
               
                 539 
                 IPI00926109 
                   
                 DHX30 
               
               
                 540 
                 IPI00027415 
                   
                 DHX36 
               
               
                 541 
                 IPI00008575 
                   
                 Khdrbs1 
               
               
                 542 
                 IPI00844215 
                   
                 SPTAN1 
               
               
                 543 
                 IPI00010800 
                   
                 NES 
               
               
                 544 
                 IPI00004669 
                   
                 GALNT2 
               
               
                 545 
                 IPI00022145 
                   
                 Nucks1 
               
               
                 546 
                 IPI00013002 
                   
                 UBE2C 
               
               
                 547 
                 IPI00021537 
                   
                 Ogfr 
               
               
                 548 
                 IPI00004416 
                   
                 CHMP2A 
               
               
                 549 
                 IPI00643554 
                   
                 Rgs10 
               
               
                 550 
                 IPI00303292 
                   
                 KPNA1 
               
               
                 551 
                 IPI00003348 
                   
                 gnb2 
               
               
                 552 
                 IPI00456925 
                   
                 DBNL 
               
               
                 553 
                 IPI00964764 
               
               
                 554 
                 IPI00977912 
               
               
                 555 
                 IPI00945725 
                   
                 Eif2a 
               
               
                 556 
                 IPI00009680 
                   
                 mrpl44 
               
               
                 557 
                 IPI00456359 
                   
                 ATXN2L 
               
               
                 558 
                 IPI00478657 
                   
                 Grsf1 
               
               
                 559 
                 IPI00916112 
                   
                 BZW1 
               
               
                 560 
                 IPI00018140 
                   
                 SYNCRIP 
               
               
                 561 
                 IPI00218695 
                   
                 CALD1 
               
               
                 562 
                 IPI00793201 
                   
                 AIMP1 
               
               
                 563 
                 IPI00644037 
                   
                 Tecr 
               
               
                 564 
                 IPI00002135 
                   
                 TACC3 
               
               
                 565 
                 IPI00006034 
                   
                 CRIP2 
               
               
                 566 
                 IPI00017342 
                   
                 RHOG 
               
               
                 567 
                 IPI00291893 
                   
                 DCUN1D1 
               
               
                 568 
                 IPI00023974 
                   
                 Pttg1ip 
               
               
                 569 
                 IPI00295772 
                   
                 CYP51A1 
               
               
                 570 
                 IPI00216975 
                   
                 TPM4 
               
               
                 571 
                 IPI00448751 
                   
                 KIAA1598 
               
               
                 572 
                 IPI00554742 
                   
                 API5L1 
               
               
                 573 
                 IPI00954530 
                   
                 ociad1 
               
               
                 574 
                 IPI01011108 
               
               
                 575 
                 IPI01022179 
               
               
                 576 
                 IPI00216230 
                   
                 TMPO 
               
               
                 577 
                 IPI00306280 
                   
                 DENR 
               
               
                 578 
                 IPI00022002 
                   
                 MRPS27 
               
               
                 579 
                 IPI00022078 
                   
                 ndrg1 
               
               
                 580 
                 IPI00012795 
                   
                 EIF3I 
               
               
                 581 
                 IPI00170935 
                   
                 Lrrc47 
               
               
                 582 
                 IPI00293655 
                   
                 DDX1 
               
               
                 583 
                 IPI00427330 
                   
                 SBDS 
               
               
                 584 
                 IPI00910513 
                   
                 GSPT1 
               
               
                 585 
                 IPI00220152 
                   
                 bccip 
               
               
                 586 
                 IPI00640703 
                   
                 Xpo5 
               
               
                 587 
                 IPI00016910 
                   
                 EIF3C 
               
               
                 588 
                 IPI00013808 
                   
                 actn4 
               
               
                 589 
                 IPI00182757 
                   
                 KIAA1967 
               
               
                 590 
                 IPI00024364 
                   
                 tnpo1 
               
               
                 591 
                 IPI00009057 
                   
                 G3BP2 
               
               
                 592 
                 IPI00479306 
                   
                 PSMB5 
               
               
                 593 
                 IPI00329536 
                   
                 EEA1 
               
               
                 594 
                 IPI00299095 
                   
                 snx2 
               
               
                 595 
                 IPI00549189 
                   
                 THOP1 
               
               
                 596 
                 IPI00954806 
               
               
                 597 
                 IPI00297084 
               
               
                 598 
                 IPI00554777 
                   
                 asnS 
               
               
                 599 
                 IPI00028004 
                   
                 PSMB3 
               
               
                 600 
                 IPI00006167 
                   
                 Ppm1g 
               
               
                 601 
                 IPI00009315 
                   
                 ACBD3 
               
               
                 602 
                 IPI00472498 
               
               
                 603 
                 IPI00555597 
                   
                 ptrh2 
               
               
                 604 
                 IPI00334159 
                   
                 vbp1 
               
               
                 605 
                 IPI00219622 
                   
                 psmA2 
               
               
                 606 
                 IPI00976779 
               
               
                 607 
                 IPI00411706 
                   
                 esd 
               
               
                 608 
                 IPI00903226 
                   
                 HK1 
               
               
                 609 
                 IPI00218493 
                   
                 HPRT1 
               
               
                 610 
                 IPI00604664 
                   
                 NDUFS1 
               
               
                 611 
                 IPI00024650 
                   
                 SLC16A1 
               
               
                 612 
                 IPI00419249 
                   
                 Psma3 
               
               
                 613 
                 IPI00015954 
                   
                 sar1a 
               
               
                 614 
                 IPI00056357 
                   
                 c19orf10 
               
               
                 615 
                 IPI00008569 
                   
                 YKT6 
               
               
                 616 
                 IPI00925046 
                   
                 QARS 
               
               
                 617 
                 IPI00011250 
                   
                 Uchl3 
               
               
                 618 
                 IPI00013214 
                   
                 MCM3 
               
               
                 619 
                 IPI00290142 
                   
                 CTPS 
               
               
                 620 
                 IPI00015148 
                   
                 Rap1b 
               
               
                 621 
                 IPI00478231 
                   
                 Rhoa 
               
               
                 622 
                 IPI00784614 
                   
                 41161 
               
               
                 623 
                 IPI00014898 
                   
                 LOC652460 
               
               
                 624 
                 IPI00028481 
                   
                 RAB8A 
               
               
                 625 
                 IPI00555956 
                   
                 PSMB4 
               
               
                 626 
                 IPI00746004 
                   
                 Rps27l 
               
               
                 627 
                 IPI00218466 
                   
                 SEC61A1 
               
               
                 628 
                 IPI00020928 
                   
                 TFAM 
               
               
                 629 
                 IPI00442073 
                   
                 CSRP1 
               
               
                 630 
                 IPI00386803 
                   
                 LASP1 
               
               
                 631 
                 IPI00011876 
                   
                 mtaP 
               
               
                 632 
                 IPI00410215 
                   
                 bpnt1 
               
               
                 633 
                 IPI00010349 
                   
                 AGPS 
               
               
                 634 
                 IPI00646954 
                   
                 Enah 
               
               
                 635 
                 IPI00440703 
                   
                 gstk1 
               
               
                 636 
                 IPI00221226 
                   
                 ANXA6 
               
               
                 637 
                 IPI00003419 
                   
                 LOC645086 
               
               
                 638 
                 IPI00063827 
                   
                 ABHD14B 
               
               
                 639 
                 IPI00789101 
                   
                 Ptges3 
               
               
                 640 
                 IPI00013195 
                   
                 MRPL49 
               
               
                 641 
                 IPI00441473 
                   
                 prmt5 
               
               
                 642 
                 IPI00414320 
                   
                 anxa11 
               
               
                 643 
                 IPI00647635 
                   
                 GIGYF2 
               
               
                 644 
                 IPI00386114 
                   
                 Sf1 
               
               
                 645 
                 IPI00168388 
                   
                 SRP68 
               
               
                 646 
                 IPI00007928 
                   
                 Prpf8 
               
               
                 647 
                 IPI00018627 
                   
                 naa50 
               
               
                 648 
                 IPI00376344 
                   
                 MYO1B 
               
               
                 649 
                 IPI00215918 
                   
                 ARF4 
               
               
                 650 
                 IPI00872359 
                   
                 DCTN1 
               
               
                 651 
                 IPI00291939 
                   
                 Smc1a 
               
               
                 652 
                 IPI00007321 
                   
                 Lypla1 
               
               
                 653 
                 IPI00003327 
                   
                 Arl3 
               
               
                 654 
                 IPI00294879 
                   
                 rangap1 
               
               
                 655 
                 IPI00452731 
                   
                 Ndufa7 
               
               
                 656 
                 IPI00398922 
                   
                 ppp1r14b 
               
               
                 657 
                 IPI00215920 
                   
                 Arf6 
               
               
                 658 
                 IPI00642584 
                   
                 KIAA0090 
               
               
                 659 
                 IPI00219420 
                   
                 smc3 
               
               
                 660 
                 IPI00645446 
               
               
                 661 
                 IPI00018768 
                   
                 TSN 
               
               
                 662 
                 IPI00641582 
                   
                 bag3 
               
               
                 663 
                 IPI00414819 
                   
                 SKIV2L 
               
               
                 664 
                 IPI00394838 
                   
                 ACLY 
               
               
                 665 
                 IPI00004902 
                   
                 etfB 
               
               
                 666 
                 IPI00927647 
                   
                 por 
               
               
                 667 
                 IPI00005904 
                   
                 ddx20 
               
               
                 668 
                 IPI00061108 
                   
                 mrrf 
               
               
                 669 
                 IPI00307092 
                   
                 KARS 
               
               
                 670 
                 IPI00910701 
                   
                 AARS 
               
               
                 671 
                 IPI00395694 
                   
                 TNPO3 
               
               
                 672 
                 IPI00641924 
                   
                 MRPS9 
               
               
                 673 
                 IPI00552587 
                   
                 gadd45gip1 
               
               
                 674 
                 IPI00783656 
                   
                 Mrpl38 
               
               
                 675 
                 IPI00856045 
                   
                 AHNAK2 
               
               
                 676 
                 IPI00025277 
                   
                 pdcd6 
               
               
                 677 
                 IPI00909773 
                   
                 ube2l3 
               
               
                 678 
                 IPI00013933 
                   
                 dsp 
               
               
                 679 
                 IPI00430812 
                   
                 CNBP 
               
               
                 680 
                 IPI00328715 
                   
                 MTDH 
               
               
                 681 
                 IPI00941649 
                   
                 HNRNPR 
               
               
                 682 
                 IPI00006181 
                   
                 eif3d 
               
               
                 683 
                 IPI00028122 
                   
                 PSIP1 
               
               
                 684 
                 IPI00894287 
                   
                 HDLBP 
               
               
                 685 
                 IPI00232533 
                   
                 EIF1AX 
               
               
                 686 
                 IPI00020508 
                   
                 Trmt1 
               
               
                 687 
                 IPI00306043 
                   
                 YTHDF2 
               
               
                 688 
                 IPI00375441 
                   
                 FUBP1 
               
               
                 689 
                 IPI00101186 
                   
                 Rrp12 
               
               
                 690 
                 IPI00165230 
                   
                 DAZAP1 
               
               
                 691 
                 IPI00005162 
                   
                 ARPC3 
               
               
                 692 
                 IPI00018274 
                   
                 egfr 
               
               
                 693 
                 IPI00334282 
                   
                 FAM3C 
               
               
                 694 
                 IPI00220194 
                   
                 slc2a1 
               
               
                 695 
                 IPI00001676 
                   
                 Nploc4 
               
               
                 696 
                 IPI00218465 
                   
                 plaa 
               
               
                 697 
                 IPI00642211 
                   
                 Rnpep 
               
               
                 698 
                 IPI00290198 
                   
                 IL18 
               
               
                 699 
                 IPI00017381 
                   
                 RfC4 
               
               
                 700 
                 IPI00219682 
                   
                 stom 
               
               
                 701 
                 IPI00386271 
                   
                 slc25a12 
               
               
                 702 
                 IPI00397860 
                   
                 cyb5a 
               
               
                 703 
                 IPI00797038 
                   
                 pck2 
               
               
                 704 
                 IPI00556027 
                   
                 BAG5 
               
               
                 705 
                 IPI00028160 
                   
                 HMBS 
               
               
                 706 
                 IPI00001091 
                   
                 AFG3L2 
               
               
                 707 
                 IPI00796379 
                   
                 B2M 
               
               
                 708 
                 IPI00012490 
                   
                 atp2b4 
               
               
                 709 
                 IPI00025717 
                   
                 MTX2 
               
               
                 710 
                 IPI00007682 
                   
                 Atp6v1a 
               
               
                 711 
                 IPI00027717 
                   
                 GEMIN4 
               
               
                 712 
                 IPI00005129 
                   
                 SCAMP1 
               
               
                 713 
                 IPI00395939 
                   
                 PITPNB 
               
               
                 714 
                 IPI00443909 
                   
                 Cnpy2 
               
               
                 715 
                 IPI00011662 
                   
                 Spint2 
               
               
                 716 
                 IPI00307200 
                   
                 SWAP70 
               
               
                 717 
                 IPI00026850 
                   
                 tspO 
               
               
                 718 
                 IPI00014808 
                   
                 PAFAH1B3 
               
               
                 719 
                 IPI00010438 
                   
                 snap23 
               
               
                 720 
                 IPI00009111 
                   
                 TPBG 
               
               
                 721 
                 IPI00019329 
                   
                 dynll1 
               
               
                 722 
                 IPI00027240 
                   
                 gng5 
               
               
                 723 
                 IPI00893197 
                   
                 ppp2r4 
               
               
                 724 
                 IPI00657752 
                   
                 CD81 
               
               
                 725 
                 IPI00217519 
                   
                 RALA 
               
               
                 726 
                 IPI00550364 
                   
                 pgm2 
               
               
                 727 
                 IPI00011285 
                   
                 CAPN1 
               
               
                 728 
                 IPI00005737 
                   
                 SURF4 
               
               
                 729 
                 IPI00303868 
                   
                 GYS1 
               
               
                 730 
                 IPI00027422 
                   
                 ITGB4 
               
               
                 731 
                 IPI00216984 
                   
                 Calml3 
               
               
                 732 
                 IPI00793381 
                   
                 PSMD6 
               
               
                 733 
                 IPI00008599 
                   
                 EBP 
               
               
                 734 
                 IPI00219147 
                   
                 CSDAP1 
               
               
                 735 
                 IPI00184363 
                   
                 GLTPP1 
               
               
                 736 
                 IPI00329596 
                   
                 TMX2 
               
               
                 737 
                 IPI00784320 
                   
                 Fam83h 
               
               
                 738 
                 IPI00384497 
                   
                 ptplb 
               
               
                 739 
                 IPI00030820 
                   
                 MRPL47 
               
               
                 740 
                 IPI00554711 
                   
                 JUP 
               
               
                 741 
                 IPI00000821 
                   
                 mrpl16 
               
               
                 742 
                 IPI00641384 
                   
                 SEC16A 
               
               
                 743 
                 IPI00329036 
                   
                 MRPL50 
               
               
                 744 
                 IPI00247439 
                   
                 SLK 
               
               
                 745 
                 IPI00242630 
                   
                 heatr2 
               
               
                 746 
                 IPI00020472 
                   
                 Tmem111 
               
               
                 747 
                 IPI00029048 
                   
                 TTLL12 
               
               
                 748 
                 IPI00016608 
                   
                 Tmed2 
               
               
                 749 
                 IPI00072534 
                   
                 UNC45A 
               
               
                 750 
                 IPI00100748 
                   
                 HSPBP1 
               
               
                 751 
                 IPI00221232 
                   
                 GNG12 
               
               
                 752 
                 IPI00008998 
                   
                 ptplad1 
               
               
                 753 
                 IPI00855820 
                   
                 MON2 
               
               
                 754 
                 IPI00329629 
                   
                 DNAJC7 
               
               
                 755 
                 IPI00018311 
                   
                 NPTN 
               
               
                 756 
                 IPI00170972 
                   
                 C9orf64 
               
               
                 757 
                 IPI00302740 
                   
                 RPS4Y1 
               
               
                 758 
                 IPI00030767 
                   
                 C19orf33 
               
               
                 759 
                 IPI00171856 
                   
                 Dohh 
               
               
                 760 
                 IPI00790064 
               
               
                 761 
                 IPI00955780 
               
               
                 762 
                 IPI00981914 
               
               
                 763 
                 IPI00980045 
               
               
                 764 
                 IPI00220300 
               
               
                 765 
                 IPI00030357 
               
               
                 766 
                 IPI01021243 
               
               
                 767 
                 IPI00298406 
                   
                 hadh 
               
               
                 768 
                 IPI00107753 
                   
                 Opa1 
               
               
                 769 
                 IPI00005158 
                   
                 lonp1 
               
               
                 770 
                 IPI00643591 
                   
                 Ap1g1 
               
               
                 771 
                 IPI00007752 
                   
                 TUBB2C 
               
               
                 772 
                 IPI00013466 
                   
                 Asna1 
               
               
                 773 
                 IPI00221224 
                   
                 ANPEP 
               
               
                 774 
                 IPI00032064 
                   
                 akap2 
               
               
                 775 
                 IPI00029046 
                   
                 Mlec 
               
               
                 776 
                 IPI00644008 
                   
                 ELAVL2 
               
               
                 777 
                 IPI00444452 
                   
                 MOV10 
               
               
                 778 
                 IPI00456363 
                   
                 ATXN2L 
               
               
                 779 
                 IPI00456969 
                   
                 DYNC1H1 
               
               
                 780 
                 IPI00221106 
                   
                 SF3B2 
               
               
                 781 
                 IPI00646917 
                   
                 NUDT21 
               
               
                 782 
                 IPI00418313 
                   
                 ilf3 
               
               
                 783 
                 IPI00217661 
                   
                 RAVER1 
               
               
                 784 
                 IPI00025815 
                   
                 TARDBP 
               
               
                 785 
                 IPI00005154 
                   
                 ssrp1 
               
               
                 786 
                 IPI00290460 
                   
                 eif3g 
               
               
                 787 
                 IPI00029629 
                   
                 TRIM25 
               
               
                 788 
                 IPI00844264 
                   
                 CSDE1 
               
               
                 789 
                 IPI00022228 
                   
                 HDLBP 
               
               
                 790 
                 IPI00008982 
                   
                 ALDH18A1 
               
               
                 791 
                 IPI00073713 
                   
                 MSI2 
               
               
                 792 
                 IPI00334587 
                   
                 Hnrnpab 
               
               
                 793 
                 IPI00023334 
                   
                 mRpL4 
               
               
                 794 
                 IPI00026519 
                   
                 PPIF 
               
               
                 795 
                 IPI00003927 
                   
                 ppiD 
               
               
                 796 
                 IPI00021435 
                   
                 PSMC2 
               
               
                 797 
                 IPI00008868 
                   
                 MAP1B 
               
               
                 798 
                 IPI00304409 
                   
                 carhsp1 
               
               
                 799 
                 IPI00299594 
                   
                 NRP1 
               
               
                 800 
                 IPI00018783 
                   
                 itpa 
               
               
                 801 
                 IPI00024913 
                   
                 C21orf33 
               
               
                 802 
                 IPI00006451 
                   
                 Nsf 
               
               
                 803 
                 IPI00299402 
                   
                 Pc 
               
               
                 804 
                 IPI00291136 
                   
                 COL6A1 
               
               
                 805 
                 IPI00021267 
                   
                 EPHA2 
               
               
                 806 
                 IPI00017375 
                   
                 SEC23A 
               
               
                 807 
                 IPI00296053 
                   
                 FH 
               
               
                 808 
                 IPI00641743 
                   
                 Hcfc1 
               
               
                 809 
                 IPI00017303 
                   
                 Msh2 
               
               
                 810 
                 IPI00394758 
                   
                 aldh3a2 
               
               
                 811 
                 IPI00218319 
                   
                 TPM3 
               
               
                 812 
                 IPI00011118 
                   
                 rrm2 
               
               
                 813 
                 IPI00413451 
                   
                 serpinb6 
               
               
                 814 
                 IPI00219025 
                   
                 GLRX 
               
               
                 815 
                 IPI00024307 
                   
                 efnb1 
               
               
                 816 
                 IPI00025239 
                   
                 ndufs2 
               
               
                 817 
                 IPI00021338 
                   
                 dlaT 
               
               
                 818 
                 IPI00030781 
                   
                 STAT1 
               
               
                 819 
                 IPI00030363 
                   
                 ACAT1 
               
               
                 820 
                 IPI00306290 
                   
                 Xpot 
               
               
                 821 
                 IPI00021440 
                   
                 ACTG1 
               
               
                 822 
                 IPI00335385 
                   
                 DCPS 
               
               
                 823 
                 IPI00155601 
                   
                 macrod1 
               
               
                 824 
                 IPI00941810 
                   
                 nomo3 
               
               
                 825 
                 IPI00168479 
                   
                 APOA1BP 
               
               
                 826 
                 IPI00303568 
                   
                 PTGES2 
               
               
                 827 
                 IPI00292953 
                   
                 RAI14 
               
               
                 828 
                 IPI00147874 
                   
                 NANS 
               
               
                 829 
                 IPI00219729 
                   
                 Slc25a11 
               
               
                 830 
                 IPI00003968 
                   
                 NDUFA9 
               
               
                 831 
                 IPI00305978 
                   
                 AKR7A2 
               
               
                 832 
                 IPI00012837 
                   
                 Kif5b 
               
               
                 833 
                 IPI00219675 
                   
                 rac1 
               
               
                 834 
                 IPI00023919 
                   
                 PSMC5 
               
               
                 835 
                 IPI00024664 
                   
                 USP5 
               
               
                 836 
                 IPI00304577 
                   
                 AP2A1 
               
               
                 837 
                 IPI00000811 
                   
                 PSMB6 
               
               
                 838 
                 IPI00008219 
                   
                 RAD23A 
               
               
                 839 
                 IPI00293464 
                   
                 DDB1 
               
               
                 840 
                 IPI00873355 
                   
                 ANXA10 
               
               
                 841 
                 IPI00002441 
                   
                 sdc1 
               
               
                 842 
                 IPI00292020 
                   
                 SRM 
               
               
                 843 
                 IPI00217943 
                   
                 LOC150786 
               
               
                 844 
                 IPI00023510 
                   
                 rab5a 
               
               
                 845 
                 IPI00783625 
                   
                 SERPINB5 
               
               
                 846 
                 IPI00291510 
                   
                 lmpdh2 
               
               
                 847 
                 IPI00926935 
                   
                 gnai2 
               
               
                 848 
                 IPI00027444 
                   
                 SERPINB1 
               
               
                 849 
                 IPI00794221 
                   
                 DBN1 
               
               
                 850 
                 IPI00384456 
                   
                 msh6 
               
               
                 851 
                 IPI00553177 
                   
                 SERPINA1 
               
               
                 852 
                 IPI00646899 
                   
                 RPL10P15 
               
               
                 853 
                 IPI00102864 
                   
                 HK2P1 
               
               
                 854 
                 IPI00016568 
                   
                 AK3L2 
               
               
                 855 
                 IPI00009659 
                   
                 RPRD1B 
               
               
                 856 
                 IPI00031564 
                   
                 Ggct 
               
               
                 857 
                 IPI00007144 
                   
                 RPL26L1 
               
               
                 858 
                 IPI00019148 
                   
                 C14orf19 
               
               
                 859 
                 IPI00290039 
                   
                 CDCP1 
               
               
                 860 
                 IPI00031131 
                   
                 C20orf3 
               
               
                 861 
                 IPI00054042 
                   
                 LOC100093631 
               
               
                 862 
                 IPI00010154 
                   
                 GDI1 
               
               
                 863 
                 IPI00895800 
                   
                 INF2 
               
               
                 864 
                 IPI00604773 
                   
                 PODXL 
               
               
                 865 
                 IPI00000690 
                   
                 AIFM1 
               
               
                 866 
                 IPI00014361 
                   
                 TSTA3 
               
               
                 867 
                 IPI00014577 
                   
                 RAB18 
               
               
                 868 
                 IPI00514501 
                   
                 C1orf57 
               
               
                 869 
                 IPI00549467 
                   
                 NIT2 
               
               
                 870 
                 IPI00007102 
                   
                 GLOD4 
               
               
                 871 
                 IPI00005578 
                   
                 Ehd4 
               
               
                 872 
                 IPI00023647 
                   
                 UBA6 
               
               
                 873 
                 IPI00337494 
                   
                 slc25a24 
               
               
                 874 
                 IPI00383046 
                   
                 Cmbl 
               
               
                 875 
                 IPI00006952 
                   
                 LACTB2 
               
               
                 876 
                 IPI00955965 
               
               
                 877 
                 IPI00892541 
               
               
                 878 
                 IPI01025218 
               
               
                 879 
                 IPI00975549 
               
               
                 880 
                 IPI00550308 
               
               
                 881 
                 IPI01022651 
               
               
                 882 
                 IPI00985090 
               
               
                 883 
                 IPI01013419 
               
               
                 884 
                 IPI01009057 
               
               
                 885 
                 IPI01021966 
               
               
                 886 
                 IPI00013508 
                   
                 actn1 
               
               
                 887 
                 IPI00216260 
                   
                 TSFM 
               
               
                 888 
                 IPI00908931 
                   
                 PDCD5 
               
               
                 889 
                 IPI00744648 
                   
                 Spag9 
               
               
                 890 
                 IPI00748244 
                   
                 Spag9 
               
               
                 891 
                 IPI00783862 
                   
                 BLVRB 
               
               
                 892 
                 IPI00152692 
                   
                 HARS2 
               
               
                 893 
                 IPI00003482 
                   
                 DECR1 
               
               
                 894 
                 IPI00003269 
                   
                 Actbl2 
               
               
                 895 
                 IPI00328170 
                   
                 mogs 
               
               
                 896 
                 IPI00075607 
                   
                 fam192a 
               
               
                 897 
                 IPI00019903 
                   
                 TACO1 
               
               
                 898 
                 IPI00000948 
                   
                 tbl2 
               
               
                 899 
                 IPI00554469 
                   
                 IMMT 
               
               
                 900 
                 IPI00022793 
                   
                 hadhb 
               
               
                 901 
                 IPI00895806 
                   
                 CNBP 
               
               
                 902 
                 IPI00945964 
                   
                 GFM1 
               
               
                 903 
                 IPI00031583 
                   
                 USO1 
               
               
                 904 
                 IPI00026496 
                   
                 NPM3 
               
               
                 905 
                 IPI00299254 
                   
                 Eif5b 
               
               
                 906 
                 IPI00298289 
                   
                 rtn4 
               
               
                 907 
                 IPI00641579 
                   
                 Cirbp 
               
               
                 908 
                 IPI00942186 
                   
                 AKAP1 
               
               
                 909 
                 IPI00784161 
                   
                 SUPT6H 
               
               
                 910 
                 IPI00021327 
                   
                 GRB2 
               
               
                 911 
                 IPI00945864 
                   
                 FXR1 
               
               
                 912 
                 IPI00060627 
                   
                 CCDC124 
               
               
                 913 
                 IPI00641948 
                   
                 FUBP1 
               
               
                 914 
                 IPI00011937 
                   
                 Prdx4 
               
               
                 915 
                 IPI00016346 
                   
                 PROSC 
               
               
                 916 
                 IPI00550181 
                   
                 Chmp2b 
               
               
                 917 
                 IPI00025244 
                   
                 ZNF259 
               
               
                 918 
                 IPI00384028 
                   
                 Papola 
               
               
                 919 
                 IPI00022314 
                   
                 Sod2 
               
               
                 920 
                 IPI00017895 
                   
                 Gpd2 
               
               
                 921 
                 IPI00294158 
                   
                 BLVRA 
               
               
                 922 
                 IPI00514424 
                   
                 PPT1 
               
               
                 923 
                 IPI00021831 
                   
                 PRKAR1A 
               
               
                 924 
                 IPI00464979 
                   
                 SUCLA2 
               
               
                 925 
                 IPI00012828 
                   
                 Acaa1 
               
               
                 926 
                 IPI00027180 
                   
                 zmpste24 
               
               
                 927 
                 IPI00032831 
                   
                 Snap29 
               
               
                 928 
                 IPI00026663 
                   
                 ALDH1A3 
               
               
                 929 
                 IPI00018272 
                   
                 Pnpo 
               
               
                 930 
                 IPI00216172 
                   
                 lamp2 
               
               
                 931 
                 IPI00019912 
                   
                 hsd17b4 
               
               
                 932 
                 IPI00019383 
                   
                 Galk1 
               
               
                 933 
                 IPI00152900 
                   
                 Lzic 
               
               
                 934 
                 IPI00218924 
                   
                 Chp 
               
               
                 935 
                 IPI00925804 
                   
                 aip 
               
               
                 936 
                 IPI00011307 
                   
                 mthfd2 
               
               
                 937 
                 IPI00220342 
                   
                 DDAH1 
               
               
                 938 
                 IPI00015947 
                   
                 DNAJB1 
               
               
                 939 
                 IPI00743293 
                   
                 RTN3 
               
               
                 940 
                 IPI00096066 
                   
                 LOC283398 
               
               
                 941 
                 IPI00003565 
                   
                 PSMD10 
               
               
                 942 
                 IPI00010415 
                   
                 ACOT7 
               
               
                 943 
                 IPI00019169 
                   
                 SH3GL1 
               
               
                 944 
                 IPI00396630 
                   
                 PRKACA 
               
               
                 945 
                 IPI00010157 
                   
                 mat2a 
               
               
                 946 
                 IPI00479722 
                   
                 PSME1 
               
               
                 947 
                 IPI00300567 
                   
                 dci 
               
               
                 948 
                 IPI00008986 
                   
                 SLC7A5 
               
               
                 949 
                 IPI00013871 
                   
                 Rrm1 
               
               
                 950 
                 IPI00017344 
                   
                 rab5b 
               
               
                 951 
                 IPI00910544 
                   
                 SERPINB5 
               
               
                 952 
                 IPI00246975 
                   
                 GSTM3 
               
               
                 953 
                 IPI00000792 
                   
                 cryz 
               
               
                 954 
                 IPI00455473 
                   
                 MIA3 
               
               
                 955 
                 IPI00033022 
                   
                 DNM2 
               
               
                 956 
                 IPI00300299 
                   
                 SPCS3 
               
               
                 957 
                 IPI00005948 
                   
                 mri1 
               
               
                 958 
                 IPI00026970 
                   
                 SUPT16HP 
               
               
                 959 
                 IPI00064193 
                   
                 TMX3 
               
               
                 960 
                 IPI00549389 
                   
                 mettl11a 
               
               
                 961 
                 IPI00063130 
                   
                 TMEM205 
               
               
                 962 
                 IPI00020530 
                   
                 ACOT13 
               
               
                 963 
                 IPI00867509 
                   
                 CORO1C 
               
               
                 964 
                 IPI00332371 
                   
                 PFKL 
               
               
                 965 
                 IPI00019927 
                   
                 psmd7 
               
               
                 966 
                 IPI00329600 
                   
                 sccpdh 
               
               
                 967 
                 IPI00009949 
                   
                 PSMF1 
               
               
                 968 
                 IPI00020075 
                   
                 ABHD10 
               
               
                 969 
                 IPI00867714 
                   
                 lsm12 
               
               
                 970 
                 IPI00023234 
                   
                 UBA2 
               
               
                 971 
                 IPI00032959 
                   
                 GPD1L 
               
               
                 972 
                 IPI00072377 
                   
                 set 
               
               
                 973 
                 IPI00065500 
                   
                 C1orf58 
               
               
                 974 
                 IPI00796864 
                   
                 DPM1 
               
               
                 975 
                 IPI00301518 
                   
                 MOBKL1B 
               
               
                 976 
                 IPI00003870 
                   
                 clpP 
               
               
                 977 
                 IPI00002525 
                   
                 NENF 
               
               
                 978 
                 IPI00166395 
                   
                 ACSF3 
               
               
                 979 
                 IPI00384857 
                   
                 HN1 
               
               
                 980 
                 IPI00513853 
                   
                 STX12 
               
               
                 981 
                 IPI00927933 
                   
                 fam136a 
               
               
                 982 
                 IPI00017283 
                   
                 iars2 
               
               
                 983 
                 IPI00410226 
                   
                 bolA2 
               
               
                 984 
                 IPI00015897 
                   
                 LOC727896 
               
               
                 985 
                 IPI00646240 
                   
                 HIST2H2BF 
               
               
                 986 
                 IPI01015321 
               
               
                 987 
                 IPI01013834 
               
               
                 988 
                 IPI00472151 
               
               
                 989 
                 IPI00963908 
               
               
                 990 
                 IPI01010281 
               
               
                 991 
                 IPI00979324 
               
               
                 992 
                 IPI00925052 
               
               
                 993 
                 IPI01018120 
               
               
                 994 
                 IPI00375531 
               
               
                 995 
                 IPI00980337 
               
               
                 996 
                 IPI00965726 
               
               
                 997 
                 IPI00759776 
                   
                 actn1 
               
               
                 998 
                 IPI00376317 
                   
                 EDC4 
               
               
                 999 
                 IPI00782965 
                   
                 HIP1 
               
               
                 1000 
                 IPI00179473 
                   
                 sqstm1 
               
               
                 1001 
                 IPI00514983 
                   
                 HSPH1 
               
               
                 1002 
                 IPI00304589 
                   
                 TNKS1BP1 
               
               
                 1003 
                 IPI00300096 
                   
                 RAB35 
               
               
                 1004 
                 IPI00221325 
                   
                 Ranbp2 
               
               
                 1005 
                 IPI00019380 
                   
                 NCBP1 
               
               
                 1006 
                 IPI00059292 
                   
                 MAGOHB 
               
               
                 1007 
                 IPI00217413 
                   
                 DHX29 
               
               
                 1008 
                 IPI00167941 
                   
                 MDN1 
               
               
                 1009 
                 IPI00016250 
                   
                 FXR2 
               
               
                 1010 
                 IPI00182533 
                   
                 rpl28 
               
               
                 1011 
                 IPI00895911 
                   
                 CNBP 
               
               
                 1012 
                 IPI00003519 
                   
                 EFTUD2 
               
               
                 1013 
                 IPI00012493 
                   
                 rps20 
               
               
                 1014 
                 IPI00100151 
                   
                 XRN2 
               
               
                 1015 
                 IPI00022184 
                   
                 PUM2 
               
               
                 1016 
                 IPI00000897 
                   
                 helz 
               
               
                 1017 
                 IPI00006987 
                   
                 DDX24 
               
               
                 1018 
                 IPI00300789 
                   
                 STAU2 
               
               
                 1019 
                 IPI00017451 
                   
                 Sf3a1 
               
               
                 1020 
                 IPI00026089 
                   
                 sf3b1 
               
               
                 1021 
                 IPI00003704 
                   
                 RBM4 
               
               
                 1022 
                 IPI00291016 
                   
                 NDUFV3 
               
               
                 1023 
                 IPI00216247 
                   
                 PSMD4 
               
               
                 1024 
                 IPI00399170 
                   
                 UPF1 
               
               
                 1025 
                 IPI00016249 
                   
                 FXR1 
               
               
                 1026 
                 IPI00293331 
                   
                 POP1 
               
               
                 1027 
                 IPI00220158 
                   
                 Add1 
               
               
                 1028 
                 IPI00419373 
                   
                 Hnrnpa3 
               
               
                 1029 
                 IPI00386189 
                   
                 naa15 
               
               
                 1030 
                 IPI00179298 
                   
                 HUWE1 
               
               
                 1031 
                 IPI00745433 
                   
                 EIF2C2 
               
               
                 1032 
                 IPI00162330 
                   
                 MRPL37 
               
               
                 1033 
                 IPI00783302 
                   
                 Ptcd3 
               
               
                 1034 
                 IPI00217686 
                   
                 Ftsj3 
               
               
                 1035 
                 IPI00396627 
                   
                 ELAC2 
               
               
                 1036 
                 IPI00012066 
                   
                 PCBP2 
               
               
                 1037 
                 IPI00006408 
                   
                 nosip 
               
               
                 1038 
                 IPI00005614 
                   
                 SPTBN1 
               
               
                 1039 
                 IPI00893067 
                   
                 eml4 
               
               
                 1040 
                 IPI00465294 
                   
                 Cdc5l 
               
               
                 1041 
                 IPI00927150 
                   
                 CHCHD3 
               
               
                 1042 
                 IPI00553024 
                   
                 EYA4 
               
               
                 1043 
                 IPI00297492 
                   
                 stt3a 
               
               
                 1044 
                 IPI00015973 
                   
                 EPB41L2 
               
               
                 1045 
                 IPI00220578 
                   
                 GNAI3 
               
               
                 1046 
                 IPI00926820 
                   
                 Slc4a7 
               
               
                 1047 
                 IPI00012369 
                   
                 Mad2l1 
               
               
                 1048 
                 IPI00289819 
                   
                 Igf2r 
               
               
                 1049 
                 IPI00513827 
                   
                 ACADM 
               
               
                 1050 
                 IPI00423570 
                   
                 Kras 
               
               
                 1051 
                 IPI00023004 
                   
                 EIF1AY 
               
               
                 1052 
                 IPI00027192 
                   
                 PLOD1 
               
               
                 1053 
                 IPI00909772 
                   
                 AP2M1 
               
               
                 1054 
                 IPI00031517 
                   
                 MCM6 
               
               
                 1055 
                 IPI00152540 
                   
                 CD109 
               
               
                 1056 
                 IPI00183054 
                   
                 MIB1 
               
               
                 1057 
                 IPI00106506 
                   
                 Ecsit 
               
               
                 1058 
                 IPI00217354 
                   
                 ARFGAP1 
               
               
                 1059 
                 IPI00220648 
                   
                 PMVK 
               
               
                 1060 
                 IPI00008436 
                   
                 Pole4 
               
               
                 1061 
                 IPI00008034 
                   
                 Rab23 
               
               
                 1062 
                 IPI00008943 
                   
                 DDX19B 
               
               
                 1063 
                 IPI00025178 
                   
                 BCAS2 
               
               
                 1064 
                 IPI00470573 
                   
                 Actr2 
               
               
                 1065 
                 IPI00021346 
                   
                 UBE2E1 
               
               
                 1066 
                 IPI00018350 
                   
                 Mcm5 
               
               
                 1067 
                 IPI00018349 
                   
                 MCM4 
               
               
                 1068 
                 IPI00927614 
                   
                 golga4 
               
               
                 1069 
                 IPI00219673 
                   
                 gstk1 
               
               
                 1070 
                 IPI00028006 
                   
                 psmb2 
               
               
                 1071 
                 IPI00945153 
                   
                 ndufa6 
               
               
                 1072 
                 IPI00908444 
                   
                 CAMK2G 
               
               
                 1073 
                 IPI00010882 
                   
                 DFFA 
               
               
                 1074 
                 IPI00007019 
                   
                 ppil1 
               
               
                 1075 
                 IPI00328257 
                   
                 AP1B1 
               
               
                 1076 
                 IPI00926925 
                   
                 Ogdh 
               
               
                 1077 
                 IPI00889196 
                   
                 uqcrfs1 
               
               
                 1078 
                 IPI00216057 
                   
                 sorD 
               
               
                 1079 
                 IPI00005179 
                   
                 Polr1c 
               
               
                 1080 
                 IPI00910088 
                   
                 ap1m1 
               
               
                 1081 
                 IPI00922181 
                   
                 mcm2 
               
               
                 1082 
                 IPI00016746 
                   
                 Cbfb 
               
               
                 1083 
                 IPI00093057 
                   
                 CPOX 
               
               
                 1084 
                 IPI00900325 
                   
                 Nup214 
               
               
                 1085 
                 IPI00002459 
                   
                 ANXA6 
               
               
                 1086 
                 IPI00020719 
                   
                 MAVS 
               
               
                 1087 
                 IPI00647457 
                   
                 HLA-A 
               
               
                 1088 
                 IPI00514550 
                   
                 DNM2 
               
               
                 1089 
                 IPI00006072 
                   
                 sec61g 
               
               
                 1090 
                 IPI00009822 
                   
                 LOC650638 
               
               
                 1091 
                 IPI00083708 
                   
                 Bat2l2 
               
               
                 1092 
                 IPI00853161 
                   
                 RPL10P15 
               
               
                 1093 
                 IPI00031801 
                   
                 CSDAP1 
               
               
                 1094 
                 IPI00479743 
                   
                 POTEE 
               
               
                 1095 
                 IPI00855856 
                   
                 API5L1 
               
               
                 1096 
                 IPI00554701 
                   
                 Uqcr10 
               
               
                 1097 
                 IPI00171626 
                   
                 lpcat1 
               
               
                 1098 
                 IPI00759658 
                   
                 MSMP 
               
               
                 1099 
                 IPI00042580 
                   
                 apoo 
               
               
                 1100 
                 IPI00007277 
                   
                 lrrfip2 
               
               
                 1101 
                 IPI00647837 
                   
                 ZNF185 
               
               
                 1102 
                 IPI00148063 
                   
                 HEBP1 
               
               
                 1103 
                 IPI00911039 
                   
                 HSPA1A 
               
               
                 1104 
                 IPI00845339 
                   
                 HSPA1A 
               
               
                 1105 
                 IPI00171421 
                   
                 C8orf55 
               
               
                 1106 
                 IPI00643435 
                   
                 atad3a 
               
               
                 1107 
                 IPI00465156 
                   
                 ADCY4 
               
               
                 1108 
                 IPI00022827 
                   
                 SLK 
               
               
                 1109 
                 IPI00419802 
                   
                 HIBCH 
               
               
                 1110 
                 IPI00872556 
                   
                 Mobkl1a 
               
               
                 1111 
                 IPI00010204 
                   
                 SFRS3 
               
               
                 1112 
                 IPI00018871 
                   
                 Arl8b 
               
               
                 1113 
                 IPI00217975 
                   
                 LMNB1 
               
               
                 1114 
                 IPI00168640 
                   
                 C19orf18 
               
               
                 1115 
                 IPI00909387 
                   
                 GHITM 
               
               
                 1116 
                 IPI00553153 
                   
                 Atpif1 
               
               
                 1117 
                 IPI00007309 
                   
                 TIMM23B 
               
               
                 1118 
                 IPI00871988 
                   
                 SFXN3 
               
               
                 1119 
                 IPI00555902 
                   
                 ociad2 
               
               
                 1120 
                 IPI00478450 
                   
                 NDUFB11 
               
               
                 1121 
                 IPI00982376 
               
               
                 1122 
                 IPI00982951 
               
               
                 1123 
                 IPI00736446 
               
               
                 1124 
                 IPI00382926 
               
               
                 1125 
                 IPI01018609 
               
               
                 1126 
                 IPI00983078 
               
               
                 1127 
                 IPI01019005 
               
               
                 1128 
                 IPI00910816 
               
               
                 1129 
                 IPI00967716 
               
               
                 1130 
                 IPI00982101 
               
               
                 1131 
                 IPI00953272 
               
               
                 1132 
                 IPI01024808 
               
               
                 1133 
                 IPI01012733 
               
               
                 1134 
                 IPI00382990 
               
               
                 1135 
                 IPI00386208 
               
               
                 1136 
                 IPI00896727 
                   
                 CAND1 
               
               
                 1137 
                 IPI00648173 
                   
                 CLTC 
               
               
                 1138 
                 IPI00123494 
                   
                 PSMD2 
               
               
                 1139 
                 IPI00125901 
                   
                 rps13 
               
               
                 1140 
                 IPI00315488 
                   
                 rars 
               
               
                 1141 
                 IPI00169463 
                   
                 TUBB2C 
               
               
                 1142 
                 IPI00108125 
                   
                 eif5a 
               
               
                 1143 
                 IPI00663627 
                   
                 FLNB 
               
               
                 1144 
                 IPI00929813 
                   
                 NAP1L1 
               
               
                 1145 
                 IPI00224152 
                   
                 Apex1 
               
               
                 1146 
                 IPI00122565 
                   
                 GDI2 
               
               
                 1147 
                 IPI00331461 
                   
                 rpl11 
               
               
                 1148 
                 IPI00133985 
                   
                 Ruvbl1 
               
               
                 1149 
                 IPI00132250 
                   
                 Eif3e 
               
               
                 1150 
                 IPI00229859 
                   
                 EIF3B 
               
               
                 1151 
                 IPI00890117 
                   
                 CFL1 
               
               
                 1152 
                 IPI00331556 
                   
                 HSPA4 
               
               
                 1153 
                 IPI00117978 
                   
                 COX4I1 
               
               
                 1154 
                 IPI00230395 
                   
                 ANXA1 
               
               
                 1155 
                 IPI00113377 
                   
                 rplp1 
               
               
                 1156 
                 IPI00116283 
                   
                 Cct3 
               
               
                 1157 
                 IPI00131357 
                   
                 rps23 
               
               
                 1158 
                 IPI00555059 
                   
                 Prdx6 
               
               
                 1159 
                 IPI00457898 
                   
                 pgam1 
               
               
                 1160 
                 IPI00342766 
                   
                 HP1BP3 
               
               
                 1161 
                 IPI00454008 
                   
                 SHMT2 
               
               
                 1162 
                 IPI00410937 
                   
                 RBM8A 
               
               
                 1163 
                 IPI00312018 
                   
                 Mlec 
               
               
                 1164 
                 IPI00776018 
                   
                 DYNC1I2 
               
               
                 1165 
                 IPI00319973 
                   
                 PGRMC1 
               
               
                 1166 
                 IPI00467833 
                   
                 TPI1 
               
               
                 1167 
                 IPI00113870 
                   
                 pcnA 
               
               
                 1168 
                 IPI00129519 
                   
                 Basp1 
               
               
                 1169 
                 IPI00163011 
                   
                 TXNDC5 
               
               
                 1170 
                 IPI00467447 
                   
                 IQGAP1 
               
               
                 1171 
                 IPI00117910 
                   
                 PRDX2 
               
               
                 1172 
                 IPI00227299 
                   
                 VIM 
               
               
                 1173 
                 IPI00123802 
                   
                 HSPH1 
               
               
                 1174 
                 IPI00944194 
                   
                 Fkbp10 
               
               
                 1175 
                 IPI00132474 
                   
                 Itgb1 
               
               
                 1176 
                 IPI00854971 
                   
                 pdia6 
               
               
                 1177 
                 IPI00757312 
                   
                 myh10 
               
               
                 1178 
                 IPI00269613 
                   
                 EIF3I 
               
               
                 1179 
                 IPI00469268 
                   
                 CCT8 
               
               
                 1180 
                 IPI00620256 
                   
                 lmna 
               
               
                 1181 
                 IPI00222514 
                   
                 MRPS27 
               
               
                 1182 
                 IPI00227808 
                   
                 CDV3 
               
               
                 1183 
                 IPI00929758 
                   
                 TLN1 
               
               
                 1184 
                 IPI00828412 
                   
                 RBBP4 
               
               
                 1185 
                 IPI00551412 
                   
                 MAGOH 
               
               
                 1186 
                 IPI00116279 
                   
                 cct5 
               
               
                 1187 
                 IPI00408495 
                   
                 bsg 
               
               
                 1188 
                 IPI00403589 
                   
                 ERH 
               
               
                 1189 
                 IPI00330862 
                   
                 EZR 
               
               
                 1190 
                 IPI00114733 
                   
                 SERPINH1 
               
               
                 1191 
                 IPI00131459 
                   
                 Nme1 
               
               
                 1192 
                 IPI00116277 
                   
                 cct4 
               
               
                 1193 
                 IPI00757359 
                   
                 Caprin1 
               
               
                 1194 
                 IPI00353563 
                   
                 fscn1 
               
               
                 1195 
                 IPI00123379 
                   
                 HDLBP 
               
               
                 1196 
                 IPI00131056 
                   
                 IGF2BP1 
               
               
                 1197 
                 IPI00762774 
                   
                 eif3d 
               
               
                 1198 
                 IPI00112448 
                   
                 rps10 
               
               
                 1199 
                 IPI00130280 
                   
                 Atp5a1 
               
               
                 1200 
                 IPI00222546 
                   
                 rpl22 
               
               
                 1201 
                 IPI00135686 
                   
                 ppiB 
               
               
                 1202 
                 IPI00116498 
                   
                 YWHAZ 
               
               
                 1203 
                 IPI00229517 
                   
                 LGALS1 
               
               
                 1204 
                 IPI00321884 
                   
                 NVL 
               
               
                 1205 
                 IPI00230133 
                   
                 Hist1h1b 
               
               
                 1206 
                 IPI00322749 
                   
                 SNRPD1 
               
               
                 1207 
                 IPI00118384 
                   
                 YWHAE 
               
               
                 1208 
                 IPI00323806 
                   
                 rpl24 
               
               
                 1209 
                 IPI00122743 
                   
                 Dars 
               
               
                 1210 
                 IPI00330804 
                   
                 HSP90AA1 
               
               
                 1211 
                 IPI00626385 
                   
                 PLEC 
               
               
                 1212 
                 IPI00123313 
                   
                 Uba1 
               
               
                 1213 
                 IPI00116302 
                   
                 Eif2s2 
               
               
                 1214 
                 IPI00230108 
                   
                 PDIA3 
               
               
                 1215 
                 IPI00123007 
                   
                 rpl31 
               
               
                 1216 
                 IPI00627049 
                   
                 RpL35A 
               
               
                 1217 
                 IPI00108271 
                   
                 ELAVL1 
               
               
                 1218 
                 IPI00137787 
                   
                 rpl8 
               
               
                 1219 
                 IPI00408796 
                   
                 Sf3a1 
               
               
                 1220 
                 IPI00830478 
                   
                 FAM120A 
               
               
                 1221 
                 IPI00323592 
                   
                 mdh2 
               
               
                 1222 
                 IPI00317740 
                   
                 GNB2L1 
               
               
                 1223 
                 IPI00224729 
                   
                 Hnrnph1 
               
               
                 1224 
                 IPI00137730 
                   
                 PEBP1 
               
               
                 1225 
                 IPI00113223 
                   
                 FASN 
               
               
                 1226 
                 IPI00270737 
                   
                 FMR1 
               
               
                 1227 
                 IPI00123639 
                   
                 CALR 
               
               
                 1228 
                 IPI00407571 
                   
                 ssrp1 
               
               
                 1229 
                 IPI00230707 
                   
                 YWHAG 
               
               
                 1230 
                 IPI00132950 
                   
                 rps21 
               
               
                 1231 
                 IPI00118676 
                   
                 EIF4A1 
               
               
                 1232 
                 IPI00128867 
                   
                 purb 
               
               
                 1233 
                 IPI00828223 
                   
                 SRP68 
               
               
                 1234 
                 IPI00117689 
                   
                 PTRF 
               
               
                 1235 
                 IPI00133903 
                   
                 HSPA9 
               
               
                 1236 
                 IPI00134599 
                   
                 rps3 
               
               
                 1237 
                 IPI00396671 
                   
                 ABCF1 
               
               
                 1238 
                 IPI00930882 
                   
                 SLC3A2 
               
               
                 1239 
                 IPI00221581 
                   
                 EIF4B 
               
               
                 1240 
                 IPI00222461 
                   
                 gnl3 
               
               
                 1241 
                 IPI00129276 
                   
                 eif3a 
               
               
                 1242 
                 IPI00108818 
                   
                 Gnl3l 
               
               
                 1243 
                 IPI00112963 
                   
                 Ctnna1 
               
               
                 1244 
                 IPI00828741 
                   
                 RALY 
               
               
                 1245 
                 IPI00120691 
                   
                 DDX21 
               
               
                 1246 
                 IPI00330599 
                   
                 MTDH 
               
               
                 1247 
                 IPI00309035 
                   
                 RPN1 
               
               
                 1248 
                 IPI00271951 
                   
                 Pdia4 
               
               
                 1249 
                 IPI00313475 
                   
                 Atp5c1 
               
               
                 1250 
                 IPI00133522 
                   
                 p4hb 
               
               
                 1251 
                 IPI00123129 
                   
                 SND1 
               
               
                 1252 
                 IPI00130883 
                   
                 RBM3 
               
               
                 1253 
                 IPI00123281 
                   
                 LRRC59 
               
               
                 1254 
                 IPI00119618 
                   
                 Canx 
               
               
                 1255 
                 IPI00420726 
                   
                 rps9 
               
               
                 1256 
                 IPI00387422 
                   
                 ZYX 
               
               
                 1257 
                 IPI00128202 
                   
                 eIF3h 
               
               
                 1258 
                 IPI00229080 
                   
                 HSP90AB1 
               
               
                 1259 
                 IPI00119876 
                   
                 DYNC1H1 
               
               
                 1260 
                 IPI00123891 
                   
                 CSRP1 
               
               
                 1261 
                 IPI00755226 
                   
                 SEC61B 
               
               
                 1262 
                 IPI00830528 
                   
                 MOV10 
               
               
                 1263 
                 IPI00223047 
                   
                 Ckap4 
               
               
                 1264 
                 IPI00133428 
                   
                 psmc1 
               
               
                 1265 
                 IPI00406117 
                   
                 SYNCRIP 
               
               
                 1266 
                 IPI00111877 
                   
                 SSBP1 
               
               
                 1267 
                 IPI00223713 
                   
                 Hist1h1c 
               
               
                 1268 
                 IPI00121514 
                   
                 stip1 
               
               
                 1269 
                 IPI00463573 
                   
                 EIF3L 
               
               
                 1270 
                 IPI00119063 
                   
                 lrp1 
               
               
                 1271 
                 IPI00116281 
                   
                 cct6a 
               
               
                 1272 
                 IPI00316133 
                   
                 SRP72 
               
               
                 1273 
                 IPI00761863 
                   
                 lgf2bp2 
               
               
                 1274 
                 IPI00944141 
                   
                 Rps5 
               
               
                 1275 
                 IPI00762542 
                   
                 rps11 
               
               
                 1276 
                 IPI00381291 
                   
                 PSMD4 
               
               
                 1277 
                 IPI00331315 
                   
                 igf2bp3 
               
               
                 1278 
                 IPI00124287 
                   
                 PABPC1 
               
               
                 1279 
                 IPI00118899 
                   
                 actn4 
               
               
                 1280 
                 IPI00111412 
                   
                 rpl4 
               
               
                 1281 
                 IPI00162790 
                   
                 RpL18A 
               
               
                 1282 
                 IPI00377441 
                   
                 RPS26 
               
               
                 1283 
                 IPI00420949 
                   
                 UPF1 
               
               
                 1284 
                 IPI00130095 
                   
                 G3BP1 
               
               
                 1285 
                 IPI00128904 
                   
                 Pcbp1 
               
               
                 1286 
                 IPI00132443 
                   
                 hnrnpm 
               
               
                 1287 
                 IPI00230035 
                   
                 DDX3X 
               
               
                 1288 
                 IPI00554845 
                   
                 IMMT 
               
               
                 1289 
                 IPI00929786 
                   
                 LARP1 
               
               
                 1290 
                 IPI00469392 
                   
                 rtn4 
               
               
                 1291 
                 IPI00124742 
                   
                 eif4h 
               
               
                 1292 
                 IPI00109764 
                   
                 TOP1 
               
               
                 1293 
                 IPI00320016 
                   
                 nonO 
               
               
                 1294 
                 IPI00127707 
                   
                 PCBP2 
               
               
                 1295 
                 IPI00828620 
                   
                 Larp4 
               
               
                 1296 
                 IPI00622371 
                   
                 eif3g 
               
               
                 1297 
                 IPI00921658 
                   
                 FLNA 
               
               
                 1298 
                 IPI00277066 
                   
                 Hnrnpab 
               
               
                 1299 
                 IPI00858249 
                   
                 Eif4g1 
               
               
                 1300 
                 IPI00330591 
                   
                 csdA 
               
               
                 1301 
                 IPI00321647 
                   
                 EIF3C 
               
               
                 1302 
                 IPI00317794 
                   
                 ncl 
               
               
                 1303 
                 IPI00119305 
                   
                 PA2G4 
               
               
                 1304 
                 IPI00126716 
                   
                 Eif4a3 
               
               
                 1305 
                 IPI00330958 
                   
                 HNRNPD 
               
               
                 1306 
                 IPI00122559 
                   
                 Ktn1 
               
               
                 1307 
                 IPI00134300 
                   
                 ssb 
               
               
                 1308 
                 IPI00471475 
                   
                 serbp1 
               
               
                 1309 
                 IPI00121758 
                   
                 TARDBP 
               
               
                 1310 
                 IPI00458583 
                   
                 Hnrnpu 
               
               
                 1311 
                 IPI00331361 
                   
                 mybbp1a 
               
               
                 1312 
                 IPI00623284 
                   
                 sf3b1 
               
               
                 1313 
                 IPI00553798 
                   
                 ahnak 
               
               
                 1314 
                 IPI00223443 
                   
                 Hnrnpc 
               
               
                 1315 
                 IPI00775950 
                   
                 CALD1 
               
               
                 1316 
                 IPI00752108 
                   
                 CTNND1 
               
               
                 1317 
                 IPI00648318 
                   
                 Ak2 
               
               
                 1318 
                 IPI00122862 
                   
                 mthfd1 
               
               
                 1319 
                 IPI00555113 
                   
                 RPL18 
               
               
                 1320 
                 IPI00229534 
                   
                 MARCKS 
               
               
                 1321 
                 IPI00667117 
                   
                 DBI 
               
               
                 1322 
                 IPI00277001 
                   
                 Psma4 
               
               
                 1323 
                 IPI00311682 
                   
                 ATP1A1 
               
               
                 1324 
                 IPI00137735 
                   
                 RPS25 
               
               
                 1325 
                 IPI00115097 
                   
                 copb2 
               
               
                 1326 
                 IPI00170008 
                   
                 snrpa1 
               
               
                 1327 
                 IPI00314736 
                   
                 ANP32A 
               
               
                 1328 
                 IPI00123181 
                   
                 MYH9 
               
               
                 1329 
                 IPI00110588 
                   
                 msn 
               
               
                 1330 
                 IPI00319992 
                   
                 HSPA5 
               
               
                 1331 
                 IPI00849793 
                   
                 rpl12 
               
               
                 1332 
                 IPI00111831 
                   
                 Naca 
               
               
                 1333 
                 IPI00457499 
                   
                 gcn1l1 
               
               
                 1334 
                 IPI00230440 
                   
                 ahcY 
               
               
                 1335 
                 IPI00125778 
                   
                 TAGLN2 
               
               
                 1336 
                 IPI00119224 
                   
                 snrpd3 
               
               
                 1337 
                 IPI00129526 
                   
                 Hsp90b1 
               
               
                 1338 
                 IPI00468481 
                   
                 ATP5B 
               
               
                 1339 
                 IPI00653179 
                   
                 FKBP1A 
               
               
                 1340 
                 IPI00113536 
                   
                 anp32b 
               
               
                 1341 
                 IPI00112414 
                   
                 CSE1L 
               
               
                 1342 
                 IPI00133948 
                   
                 Fkbp2 
               
               
                 1343 
                 IPI00137409 
                   
                 tkt 
               
               
                 1344 
                 IPI00230682 
                   
                 YWHAB 
               
               
                 1345 
                 IPI00223437 
                   
                 CopG 
               
               
                 1346 
                 IPI00111271 
                   
                 srprb 
               
               
                 1347 
                 IPI00125143 
                   
                 ARPC1B 
               
               
                 1348 
                 IPI00849113 
                   
                 Fau 
               
               
                 1349 
                 IPI00226515 
                   
                 TAGLN 
               
               
                 1350 
                 IPI00131845 
                   
                 Psma6 
               
               
                 1351 
                 IPI00856379 
                   
                 ALDOA 
               
               
                 1352 
                 IPI00270326 
                   
                 PSMC2 
               
               
                 1353 
                 IPI00132194 
                   
                 AIMP1 
               
               
                 1354 
                 IPI00754096 
                   
                 clint1 
               
               
                 1355 
                 IPI00323881 
                   
                 KPNB1 
               
               
                 1356 
                 IPI00624653 
                   
                 USMG5 
               
               
                 1357 
                 IPI00133243 
                   
                 ifitm3 
               
               
                 1358 
                 IPI00127841 
                   
                 LOC631229 
               
               
                 1359 
                 IPI00132050 
                   
                 LOC675851 
               
               
                 1360 
                 IPI00120045 
                   
                 Gm2903 
               
               
                 1361 
                 IPI00114162 
                   
                 Fabp5 
               
               
                 1362 
                 IPI00474407 
                   
                 Gm8667 
               
               
                 1363 
                 IPI00132390 
                   
                 Gm3244 
               
               
                 1364 
                 IPI00874728 
                   
                 tpm2 
               
               
                 1365 
                 IPI00775791 
                   
                 manf 
               
               
                 1366 
                 IPI00928004 
                   
                 copA 
               
               
                 1367 
                 IPI00828225 
                   
                 BCAP31 
               
               
                 1368 
                 IPI00114209 
                   
                 glud1 
               
               
                 1369 
                 IPI00222419 
                   
                 Gm10108 
               
               
                 1370 
                 IPI00474446 
                   
                 Gm7459 
               
               
                 1371 
                 IPI00230660 
                   
                 Gm14166 
               
               
                 1372 
                 IPI00468203 
                   
                 LOC100048867 
               
               
                 1373 
                 IPI00153103 
                   
                 AIMP2 
               
               
                 1374 
                 IPI00469918 
                   
                 LOC100047501 
               
               
                 1375 
                 IPI00310091 
                   
                 PPP2R1A 
               
               
                 1376 
                 IPI00130322 
                   
                 Ndufa7 
               
               
                 1377 
                 IPI00113845 
                   
                 psmb1 
               
               
                 1378 
                 IPI00133931 
                   
                 FKBP11 
               
               
                 1379 
                 IPI00331174 
                   
                 Cct7 
               
               
                 1380 
                 IPI00315100 
                   
                 Gm12844 
               
               
                 1381 
                 IPI00121309 
                   
                 Gm12251 
               
               
                 1382 
                 IPI00272545 
                   
                 Gm4149 
               
               
                 1383 
                 IPI00116308 
                   
                 st13 
               
               
                 1384 
                 IPI00318548 
                   
                 Gm6978 
               
               
                 1385 
                 IPI00664670 
                   
                 FLNC 
               
               
                 1386 
                 IPI00308162 
                   
                 slc25a12 
               
               
                 1387 
                 IPI00408215 
                   
                 MYO1B 
               
               
                 1388 
                 IPI00129323 
                   
                 Gm7083 
               
               
                 1389 
                 IPI00126042 
                   
                 Rab14 
               
               
                 1390 
                 IPI00122421 
                   
                 LOC631649 
               
               
                 1391 
                 IPI00118963 
                   
                 mRpL12 
               
               
                 1392 
                 IPI00281011 
                   
                 Marcksl1-ps3 
               
               
                 1393 
                 IPI00115538 
                   
                 LOC100047211 
               
               
                 1394 
                 IPI00405227 
                   
                 vcl 
               
               
                 1395 
                 IPI00323971 
                   
                 Gm15210 
               
               
                 1396 
                 IPI00341282 
                   
                 Gm12231 
               
               
                 1397 
                 IPI00320217 
                   
                 CCT2 
               
               
                 1398 
                 IPI00929832 
                   
                 NUP205 
               
               
                 1399 
                 IPI00111770 
                   
                 Gm2972 
               
               
                 1400 
                 IPI00116120 
                   
                 Gm3837 
               
               
                 1401 
                 IPI00136251 
                   
                 Dnaja2 
               
               
                 1402 
                 IPI00114491 
                   
                 Cdk1 
               
               
                 1403 
                 IPI00222548 
                   
                 Gm5561 
               
               
                 1404 
                 IPI00123604 
                   
                 LOC676179 
               
               
                 1405 
                 IPI00623776 
                   
                 Hist1h4c 
               
               
                 1406 
                 IPI00113257 
                   
                 Gm7181 
               
               
                 1407 
                 IPI00119239 
                   
                 PSMB6 
               
               
                 1408 
                 IPI00133234 
                   
                 tmem33 
               
               
                 1409 
                 IPI00915054 
                   
                 Gm3379 
               
               
                 1410 
                 IPI00224505 
                   
                 LOC674921 
               
               
                 1411 
                 IPI00849927 
                   
                 Gm15451 
               
               
                 1412 
                 IPI00111258 
                   
                 MVP 
               
               
                 1413 
                 IPI00127942 
                   
                 DSTN 
               
               
                 1414 
                 IPI00131771 
                   
                 Gm16399 
               
               
                 1415 
                 IPI00263879 
                   
                 Gm4342 
               
               
                 1416 
                 IPI00113895 
                   
                 ACTR1A 
               
               
                 1417 
                 IPI00269661 
                   
                 Gm5550 
               
               
                 1418 
                 IPI00129178 
                   
                 OAT 
               
               
                 1419 
                 IPI00849044 
                   
                 LOC100044039 
               
               
                 1420 
                 IPI00753815 
                   
                 Spna2 
               
               
                 1421 
                 IPI00465880 
                   
                 Gm14586 
               
               
                 1422 
                 IPI00129577 
                   
                 AIFM1 
               
               
                 1423 
                 IPI00224219 
                   
                 SCFD1 
               
               
                 1424 
                 IPI00459493 
                   
                 TCP1 
               
               
                 1425 
                 IPI00606508 
                   
                 Gm9168 
               
               
                 1426 
                 IPI00338964 
                   
                 ATP2A2 
               
               
                 1427 
                 IPI00465568 
                   
                 Gm11878 
               
               
                 1428 
                 IPI00227835 
                   
                 TPM1 
               
               
                 1429 
                 IPI00221613 
                   
                 Gm8230 
               
               
                 1430 
                 IPI00125460 
                   
                 LOC674583 
               
               
                 1431 
                 IPI00117352 
                   
                 Tubb5 
               
               
                 1432 
                 IPI00420261 
                   
                 LOC674543 
               
               
                 1433 
                 IPI00620145 
                   
                 LOC631033 
               
               
                 1434 
                 IPI00224784 
                   
                 Gm7614 
               
               
                 1435 
                 IPI00120716 
                   
                 GNB1 
               
               
                 1436 
                 IPI00944143 
                   
                 Serpinb6a 
               
               
                 1437 
                 IPI00230507 
                   
                 LOC674469 
               
               
                 1438 
                 IPI00113660 
                   
                 PSME3 
               
               
                 1439 
                 IPI00118986 
                   
                 Gm5436 
               
               
                 1440 
                 IPI00404551 
                   
                 CTSD 
               
               
                 1441 
                 IPI00225634 
                   
                 Gm6646 
               
               
                 1442 
                 IPI00283862 
                   
                 PSMA1 
               
               
                 1443 
                 IPI00109611 
                   
                 Fam162a 
               
               
                 1444 
                 IPI00117705 
                   
                 DDOST 
               
               
                 1445 
                 IPI00136310 
                   
                 MRPL23 
               
               
                 1446 
                 IPI00115580 
                   
                 EIF3M 
               
               
                 1447 
                 IPI00230427 
                   
                 Gm16379 
               
               
                 1448 
                 IPI00128491 
                   
                 Aprt 
               
               
                 1449 
                 IPI00121288 
                   
                 NDUFB10 
               
               
                 1450 
                 IPI00108895 
                   
                 psmc4 
               
               
                 1451 
                 IPI00132722 
                   
                 LOC100045085 
               
               
                 1452 
                 IPI00109044 
                   
                 2900073G15Rik 
               
               
                 1453 
                 IPI00113655 
                   
                 Gm6476 
               
               
                 1454 
                 IPI00656325 
                   
                 Nsf 
               
               
                 1455 
                 IPI00119219 
                   
                 HSD17B12 
               
               
                 1456 
                 IPI00122568 
                   
                 arhgdib 
               
               
                 1457 
                 IPI00875584 
                   
                 Gm9646 
               
               
                 1458 
                 IPI00226891 
                   
                 myef2 
               
               
                 1459 
                 IPI00850843 
                   
                 LOC100047183 
               
               
                 1460 
                 IPI00223714 
                   
                 Hist1h1e 
               
               
                 1461 
                 IPI00120100 
                   
                 P4HA2 
               
               
                 1462 
                 IPI00469218 
                   
                 lamp1 
               
               
                 1463 
                 IPI00115117 
                   
                 Stoml2 
               
               
                 1464 
                 IPI00119545 
                   
                 PFDN2 
               
               
                 1465 
                 IPI00115564 
                   
                 SLC25A4 
               
               
                 1466 
                 IPI00622235 
                   
                 LOC675857 
               
               
                 1467 
                 IPI00124771 
                   
                 SLC25A3 
               
               
                 1468 
                 IPI00322312 
                   
                 ARHGDIA 
               
               
                 1469 
                 IPI00114368 
                   
                 SEC22B 
               
               
                 1470 
                 IPI00874482 
                   
                 Actg-ps1 
               
               
                 1471 
                 IPI00123342 
                   
                 hyou1 
               
               
                 1472 
                 IPI00323819 
                   
                 Gm6440 
               
               
                 1473 
                 IPI00124096 
                   
                 Hiatl1 
               
               
                 1474 
                 IPI00135512 
                   
                 Cnpy2 
               
               
                 1475 
                 IPI00315135 
                   
                 Gm12906 
               
               
                 1476 
                 IPI00761713 
                   
                 Hist1h2bp 
               
               
                 1477 
                 IPI00473728 
               
               
                 1478 
                 IPI00225066 
                   
                 RPL36A 
               
               
                 1479 
                 IPI00130486 
                   
                 FKBP9 
               
               
                 1480 
                 IPI00652813 
                   
                 fn1 
               
               
                 1481 
                 IPI00134621 
                   
                 LOC100045999 
               
               
                 1482 
                 IPI00121788 
                   
                 Gm7204 
               
               
                 1483 
                 IPI00331597 
                   
                 Hist1h1d 
               
               
                 1484 
                 IPI00127415 
                   
                 LOC100046628 
               
               
                 1485 
                 IPI00125971 
                   
                 Psmc6 
               
               
                 1486 
                 IPI00222550 
                   
                 Gm4149 
               
               
                 1487 
                 IPI00111218 
                   
                 ALDH2 
               
               
                 1488 
                 IPI00551236 
                   
                 Stmn1-rs2 
               
               
                 1489 
                 IPI00228616 
                   
                 Hist1h1a 
               
               
                 1490 
                 IPI00131954 
                   
                 D17Wsu104e 
               
               
                 1491 
                 IPI00135869 
                   
                 RAB11B 
               
               
                 1492 
                 IPI00416279 
                   
                 GLIPR2 
               
               
                 1493 
                 IPI00130840 
                   
                 cope 
               
               
                 1494 
                 IPI00666885 
                   
                 DNAJC13 
               
               
                 1495 
                 IPI00132276 
                   
                 vamp3 
               
               
                 1496 
                 IPI00121079 
                   
                 cyb5r3 
               
               
                 1497 
                 IPI00169925 
                   
                 Ndufv2 
               
               
                 1498 
                 IPI00135475 
                   
                 DBN1 
               
               
                 1499 
                 IPI00308984 
                   
                 EIF1AY 
               
               
                 1500 
                 IPI00407130 
                   
                 Gm6560 
               
               
                 1501 
                 IPI00119138 
                   
                 Uqcrc2 
               
               
                 1502 
                 IPI00132456 
                   
                 2700060E02Rik 
               
               
                 1503 
                 IPI00130353 
                   
                 vars 
               
               
                 1504 
                 IPI00132334 
                   
                 2610030H06Rik 
               
               
                 1505 
                 IPI00228633 
                   
                 gpi1 
               
               
                 1506 
                 IPI00135186 
                   
                 CALU 
               
               
                 1507 
                 IPI00317902 
                   
                 PSMB5 
               
               
                 1508 
                 IPI00121149 
               
               
                 1509 
                 IPI00331121 
                   
                 Gm7379 
               
               
                 1510 
                 IPI00111265 
                   
                 Capza2 
               
               
                 1511 
                 IPI00226993 
                   
                 Txn1 
               
               
                 1512 
                 IPI00331092 
                   
                 Gm8729 
               
               
                 1513 
                 IPI00473521 
                   
                 Gm9058 
               
               
                 1514 
                 IPI00323820 
                   
                 mcm2 
               
               
                 1515 
                 IPI00129512 
                   
                 PSMB4 
               
               
                 1516 
                 IPI00421223 
                   
                 Gm7809 
               
               
                 1517 
                 IPI00856490 
                   
                 PSMD8 
               
               
                 1518 
                 IPI00407917 
                   
                 Gm10117 
               
               
                 1519 
                 IPI00321190 
                   
                 PSAP 
               
               
                 1520 
                 IPI00223217 
                   
                 Flt3l 
               
               
                 1521 
                 IPI00474883 
                   
                 CAPZB 
               
               
                 1522 
                 IPI00311236 
                   
                 Gm4734 
               
               
                 1523 
                 IPI00120886 
                   
                 Gm6540 
               
               
                 1524 
                 IPI00130304 
                   
                 BAG2 
               
               
                 1525 
                 IPI00319830 
                   
                 Spnb2 
               
               
                 1526 
                 IPI00117167 
                   
                 Gsn 
               
               
                 1527 
                 IPI00133249 
                   
                 SURF4 
               
               
                 1528 
                 IPI00129517 
                   
                 Prdx5 
               
               
                 1529 
                 IPI00128023 
                   
                 ndufs2 
               
               
                 1530 
                 IPI00555069 
                   
                 Pgk1-rs7 
               
               
                 1531 
                 IPI00114593 
                   
                 Actc1 
               
               
                 1532 
                 IPI00124692 
                   
                 taldo1 
               
               
                 1533 
                 IPI00271986 
                   
                 ATP5J2 
               
               
                 1534 
                 IPI00317309 
                   
                 ANXA5 
               
               
                 1535 
                 IPI00133215 
                   
                 Ndufb7 
               
               
                 1536 
                 IPI00409223 
                   
                 Gm5265 
               
               
                 1537 
                 IPI00323130 
                   
                 TCEB1 
               
               
                 1538 
                 IPI00315302 
                   
                 Ndufa2 
               
               
                 1539 
                 IPI00132756 
                   
                 ANXA8 
               
               
                 1540 
                 IPI00620156 
                   
                 LOC100047329 
               
               
                 1541 
                 IPI00270877 
                   
                 USP14 
               
               
                 1542 
                 IPI00314467 
                   
                 PSMB3 
               
               
                 1543 
                 IPI00319231 
                   
                 Gm5508 
               
               
                 1544 
                 IPI00310131 
                   
                 Ap2a2 
               
               
                 1545 
                 IPI00874935 
                   
                 LOC100046821 
               
               
                 1546 
                 IPI00273803 
                   
                 Gm8885 
               
               
                 1547 
                 IPI00420745 
                   
                 psmA2 
               
               
                 1548 
                 IPI00225201 
                   
                 iars 
               
               
                 1549 
                 IPI00408892 
                   
                 Rab7 
               
               
                 1550 
                 IPI00554894 
                   
                 ANXA6 
               
               
                 1551 
                 IPI00283671 
                   
                 2500003M10Rik 
               
               
                 1552 
                 IPI00224575 
                   
                 Gm7964 
               
               
                 1553 
                 IPI00466820 
                   
                 Gm7246 
               
               
                 1554 
                 IPI00420950 
                   
                 Gm12623 
               
               
                 1555 
                 IPI00849670 
                   
                 Myof 
               
               
                 1556 
                 IPI00135640 
                   
                 PSMC5 
               
               
                 1557 
                 IPI00114560 
                   
                 Rab1 
               
               
                 1558 
                 IPI00119220 
                   
                 Gm5449 
               
               
                 1559 
                 IPI00129685 
                   
                 Gm1974 
               
               
                 1560 
                 IPI00118344 
                   
                 UGDH 
               
               
                 1561 
                 IPI00408207 
                   
                 MYO1D 
               
               
                 1562 
                 IPI00116154 
                   
                 Gm11273 
               
               
                 1563 
                 IPI00133110 
                   
                 TXNDC12 
               
               
                 1564 
                 IPI00225390 
                   
                 COX6B1 
               
               
                 1565 
                 IPI00354819 
                   
                 Gm8894 
               
               
                 1566 
                 IPI00131176 
                   
                 COX2 
               
               
                 1567 
                 IPI00119478 
                   
                 tmod3 
               
               
                 1568 
                 IPI00227838 
                   
                 GNG12 
               
               
                 1569 
                 IPI00754649 
                   
                 LOC100048853 
               
               
                 1570 
                 IPI00120719 
                   
                 COX5A 
               
               
                 1571 
                 IPI00223092 
                   
                 HADHA 
               
               
                 1572 
                 IPI00314748 
                   
                 wdr1 
               
               
                 1573 
                 IPI00222188 
                   
                 COL1A2 
               
               
                 1574 
                 IPI00131407 
                   
                 psma5 
               
               
                 1575 
                 IPI00117829 
                   
                 cav1 
               
               
                 1576 
                 IPI00462291 
                   
                 Gm13237 
               
               
                 1577 
                 IPI00170093 
                   
                 Ndufs8 
               
               
                 1578 
                 IPI00127408 
                   
                 rac1 
               
               
                 1579 
                 IPI00130344 
                   
                 CLIC1 
               
               
                 1580 
                 IPI00230715 
                   
                 Ndufa13 
               
               
                 1581 
                 IPI00120503 
                   
                 COPB1 
               
               
                 1582 
                 IPI00132728 
                   
                 cyc1 
               
               
                 1583 
                 IPI00467172 
                   
                 LOC100048853 
               
               
                 1584 
                 IPI00853924 
                   
                 LOC674211 
               
               
                 1585 
                 IPI00467841 
                   
                 Gm7308 
               
               
                 1586 
                 IPI00331332 
                   
                 NDUFA5 
               
               
                 1587 
                 IPI00466570 
                   
                 tmed10 
               
               
                 1588 
                 IPI00115977 
                   
                 ME2 
               
               
                 1589 
                 IPI00132042 
                   
                 Gm6123 
               
               
                 1590 
                 IPI00138691 
                   
                 ARPC4 
               
               
                 1591 
                 IPI00399959 
                   
                 P4HA1 
               
               
                 1592 
                 IPI00111885 
                   
                 Uqcrc1 
               
               
                 1593 
                 IPI00137331 
                   
                 CAP1 
               
               
                 1594 
                 IPI00133066 
                   
                 PSMD12 
               
               
                 1595 
                 IPI00133240 
                   
                 uqcrfs1 
               
               
                 1596 
                 IPI00133163 
                   
                 Gm13453 
               
               
                 1597 
                 IPI00308882 
                   
                 NDUFS1 
               
               
                 1598 
                 IPI00408119 
                   
                 Mtap4 
               
               
                 1599 
                 IPI00118930 
                   
                 napA 
               
               
                 1600 
                 IPI00344004 
                   
                 NDUFA12 
               
               
                 1601 
                 IPI00228617 
                   
                 gnai2 
               
               
                 1602 
                 IPI00119111 
                   
                 Gm4815 
               
               
                 1603 
                 IPI00554989 
                   
                 Gm9234 
               
               
                 1604 
                 IPI00130589 
                   
                 Gm8566 
               
               
                 1605 
                 IPI00329872 
                   
                 COL1A1 
               
               
                 1606 
                 IPI00130240 
                   
                 ppiC 
               
               
                 1607 
                 IPI00462445 
                   
                 NEDD4 
               
               
                 1608 
                 IPI00222515 
                   
                 Psmd11 
               
               
                 1609 
                 IPI00125267 
                   
                 vapa 
               
               
                 1610 
                 IPI00648927 
                   
                 CLTA 
               
               
                 1611 
                 IPI00314439 
                   
                 psmd3 
               
               
                 1612 
                 IPI00169870 
                   
                 GLT25D1 
               
               
                 1613 
                 IPI00453777 
                   
                 Atp5d 
               
               
                 1614 
                 IPI00225961 
                   
                 Gm5207 
               
               
                 1615 
                 IPI00114945 
                   
                 41154 
               
               
                 1616 
                 IPI00139780 
                   
                 LOC100044627 
               
               
                 1617 
                 IPI00121427 
                   
                 S100A6 
               
               
                 1618 
                 IPI00224210 
                   
                 UQCRQ 
               
               
                 1619 
                 IPI00314950 
                   
                 Gm9093 
               
               
                 1620 
                 IPI00378120 
                   
                 glrx5 
               
               
                 1621 
                 IPI00222553 
                   
                 Gm10126 
               
               
                 1622 
                 IPI00139795 
                   
                 LOC100048062 
               
               
                 1623 
                 IPI00454142 
                   
                 41163 
               
               
                 1624 
                 IPI00125929 
                   
                 Ndufa4 
               
               
                 1625 
                 IPI00137736 
                   
                 Gm3511 
               
               
                 1626 
                 IPI00322562 
                   
                 Gm6204 
               
               
                 1627 
                 IPI00666161 
                   
                 LOC674215 
               
               
                 1628 
                 IPI00228113 
                   
                 MTHFD1L 
               
               
                 1629 
                 IPI00462072 
                   
                 Gm5506 
               
               
                 1630 
                 IPI00622160 
                   
                 LOC676151 
               
               
                 1631 
                 IPI00331644 
                   
                 Psma3 
               
               
                 1632 
                 IPI00474487 
                   
                 Gm10168 
               
               
                 1633 
                 IPI00110753 
                   
                 Gm7172 
               
               
                 1634 
                 IPI00132217 
                   
                 FIS1 
               
               
                 1635 
                 IPI00470152 
                   
                 Gm5928 
               
               
                 1636 
                 IPI00221540 
                   
                 Erlin2 
               
               
                 1637 
                 IPI00132460 
                   
                 Gm7606 
               
               
                 1638 
                 IPI00626233 
                   
                 Gm8358 
               
               
                 1639 
                 IPI00460103 
                   
                 Gm7857 
               
               
                 1640 
                 IPI00131406 
                   
                 PSMA7 
               
               
                 1641 
                 IPI00122426 
                   
                 Gm9188 
               
               
                 1642 
                 IPI00944009 
                   
                 Gm11675 
               
               
                 1643 
                 IPI00459353 
                   
                 Gm3150 
               
               
                 1644 
                 IPI00153660 
                   
                 dlaT 
               
               
                 1645 
                 IPI00129430 
                   
                 LOC100045887 
               
               
                 1646 
                 IPI00126048 
                   
                 PSMD13 
               
               
                 1647 
                 IPI00473429 
                   
                 Gm10051 
               
               
                 1648 
                 IPI00127598 
                   
                 Atpif1 
               
               
                 1649 
                 IPI00122549 
                   
                 VDAC1 
               
               
                 1650 
                 IPI00473445 
                   
                 LOC100046290 
               
               
                 1651 
                 IPI00117896 
                   
                 LOC674193 
               
               
                 1652 
                 IPI00751369 
                   
                 LdhA 
               
               
                 1653 
                 IPI00453924 
                   
                 RPL37 
               
               
                 1654 
                 IPI00133440 
                   
                 1700071K01Rik 
               
               
                 1655 
                 IPI00120232 
                   
                 NDUFS7 
               
               
                 1656 
                 IPI00378063 
                   
                 AP2B1 
               
               
                 1657 
                 IPI00122547 
                   
                 vdac2 
               
               
                 1658 
                 IPI00469194 
                   
                 tpp2 
               
               
                 1659 
                 IPI00313222 
                   
                 Gm5428 
               
               
                 1660 
                 IPI00331524 
                   
                 ERLIN1 
               
               
                 1661 
                 IPI00230623 
                   
                 Gm6520 
               
               
                 1662 
                 IPI00121623 
                   
                 Gm11582 
               
               
                 1663 
                 IPI00955167 
               
               
                 1664 
                 IPI00108338 
                   
                 MCM3 
               
               
                 1665 
                 IPI00323357 
                   
                 LOC641192 
               
               
                 1666 
                 IPI00221463 
                   
                 Hist3h2a 
               
               
                 1667 
                 IPI00515257 
                   
                 Gm7973 
               
               
                 1668 
                 IPI00850259 
                   
                 Gm14176 
               
               
                 1669 
                 IPI00222549 
                   
                 Gm8808 
               
               
                 1670 
                 IPI00312128 
                   
                 TRIM28 
               
               
                 1671 
                 IPI00339916 
                   
                 LOC633677 
               
               
                 1672 
                 IPI00626994 
                   
                 LOC100044315 
               
               
                 1673 
                 IPI00453819 
                   
                 LARS 
               
               
                 1674 
                 IPI00123557 
                   
                 RUVBL2 
               
               
                 1675 
                 IPI00321718 
                   
                 PHB2 
               
               
                 1676 
                 IPI00475378 
                   
                 Gm4900 
               
               
                 1677 
                 IPI00117312 
                   
                 Got2 
               
               
                 1678 
                 IPI00134809 
                   
                 DLST 
               
               
                 1679 
                 IPI00132799 
                   
                 c1qbp 
               
               
                 1680 
                 IPI00474888 
                   
                 Ptgis 
               
               
                 1681 
                 IPI00173160 
                   
                 Gm4180 
               
               
                 1682 
                 IPI00109082 
                   
                 DAD1 
               
               
                 1683 
                 IPI00120871 
                   
                 Trmt112-ps 
               
               
                 1684 
                 IPI00114401 
                   
                 emd 
               
               
                 1685 
                 IPI00875405 
                   
                 PSMD1 
               
               
                 1686 
                 IPI00113141 
                   
                 CS 
               
               
                 1687 
                 IPI00320208 
                   
                 Eef1b2 
               
               
                 1688 
                 IPI00126913 
                   
                 atad3a 
               
               
                 1689 
                 IPI00420363 
                   
                 Gm12183 
               
               
                 1690 
                 IPI00318841 
                   
                 LOC100047986 
               
               
                 1691 
                 IPI00849165 
                   
                 Gm5789 
               
               
                 1692 
                 IPI00957027 
               
               
                 1693 
                 IPI00466069 
                   
                 Gm13050 
               
               
                 1694 
                 IPI00114667 
                   
                 psmd7 
               
               
                 1695 
                 IPI00459725 
                   
                 idh3a 
               
               
                 1696 
                 IPI00850217 
                   
                 UBE2N 
               
               
                 1697 
                 IPI00330303 
                   
                 LOC100046995 
               
               
                 1698 
                 IPI00132169 
                   
                 TIMM8B 
               
               
                 1699 
                 IPI00308706 
                   
                 Gm7625 
               
               
                 1700 
                 IPI00315794 
                   
                 LOC100047577 
               
               
                 1701 
                 IPI00134484 
                   
                 Timm13 
               
               
                 1702 
                 IPI00308885 
                   
                 Gm12141 
               
               
                 1703 
                 IPI00321978 
                   
                 RanBP1 
               
               
                 1704 
                 IPI00111959 
                   
                 CTPS 
               
               
                 1705 
                 IPI00356904 
                   
                 LOC100045542 
               
               
                 1706 
                 IPI00853914 
                   
                 Gm5778 
               
               
                 1707 
                 IPI00307837 
                   
                 Gm7161 
               
               
                 1708 
                 IPI00230113 
                   
                 CYB5 
               
               
                 1709 
                 IPI00124973 
                   
                 Gm7379 
               
               
                 1710 
                 IPI00136382 
                   
                 Sdc4 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Amplified Targets 
               
             
          
           
               
                 Number 
                 GeneSymbol 
               
               
                   
               
             
          
           
               
                 1 
                 GMPS 
               
               
                 2 
                 GFM1 
               
               
                 3 
                 KPNA4 
               
               
                 4 
                 NCEH1 
               
               
                 5 
                 MRPL47 
               
               
                 6 
                 PSMD2 
               
               
                 7 
                 FXR1 
               
               
                 8 
                 TFRC 
               
               
                 9 
                 UBXN7 
               
               
                 10 
                 POP1 
               
               
                 11 
                 MTDH 
               
               
                 12 
                 PABPC1 
               
               
                 13 
                 YWHAZ 
               
               
                 14 
                 PLEC 
               
               
                 15 
                 FAM49B 
               
               
                 16 
                 PUF60 
               
               
                 17 
                 TSTA3 
               
               
                 18 
                 PSMB4 
               
               
                 19 
                 TAGLN2 
               
               
                 20 
                 HIST2H2BF 
               
               
                 21 
                 PSMD4 
               
               
                 22 
                 PFDN2 
               
               
                 23 
                 UAP1 
               
               
                 24 
                 PRKACA 
               
               
                 25 
                 TPM4 
               
               
                 26 
                 RAB8A 
               
               
                 27 
                 RAD23A 
               
               
                 28 
                 PPT1 
               
               
                 29 
                 MYCBP 
               
               
                 30 
                 PABPC4 
               
               
                 31 
                 LETM1 
               
               
                 32 
                 TACC3 
               
               
                 33 
                 MIB1 
               
               
                 34 
                 SNRPD1 
               
               
                 35 
                 PDCD5 
               
               
                 36 
                 PSMD8 
               
               
                 37 
                 PROSC 
               
               
                 38 
                 NDUFB9 
               
               
                   
               
             
          
         
       
     
       Components of the Riboproteome 
       [0044]    The one or more components of the riboproteome described herein can include, but are not limited to ribosomal protein of the small ribosome subunit and ribosomal protein of the large ribosome subunit. A list of the human ribosomal protein genes is presented in Table 3. 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 Ribosomal proteins of the small and large subunit 
               
             
          
           
               
                   
                 Small Subunit 
                 Large Subunit 
               
               
                   
                   
               
             
          
           
               
                   
                 SA 
                 RPSA 
                 L3 
                 RPL3 
               
               
                   
                 S2 
                 RPS2 
                 L4 
                 RPL4 
               
               
                   
                 S3 
                 RPS3 
                 L5 
                 RPL5 
               
               
                   
                 S3A 
                 RPS3A 
                 L6 
                 RPL6 
               
               
                   
                 S4 
                 RPS4X 
                 L7 
                 RPL7 
               
               
                   
                   
                 RPS4Y 
                 L7A 
                 RPL7A 
               
               
                   
                 S5 
                 RPS5 
                 L8 
                 RPL8 
               
               
                   
                 S6 
                 RPS6 
                 L9 
                 RPL9 
               
               
                   
                 S7 
                 RPS7 
                 L10 
                 RPL10 
               
               
                   
                 S8 
                 RPS8 
                 L10A 
                 RPL10A 
               
               
                   
                 S9 
                 RPS9 
                 L11 
                 RPL11 
               
               
                   
                 S10 
                 RPS10 
                 L12 
                 RPL12 
               
               
                   
                 S11 
                 RPS11 
                 L13 
                 RPL13 
               
               
                   
                 S12 
                 RPS12 
                 L13A 
                 RPL13A 
               
               
                   
                 S13 
                 RPS13 
                 L14 
                 RPL14 
               
               
                   
                 S14 
                 RPS14 
                 L15 
                 RPL15 
               
               
                   
                 S15 
                 RPS15 
                 L17 
                 RPL17 
               
               
                   
                 S15A 
                 RPS15A 
                 L18 
                 RPL18 
               
               
                   
                 S16 
                 RPS16 
                 L18A 
                 RPL18A 
               
               
                   
                 S17 
                 RPS17 
                 L19 
                 RPL19 
               
               
                   
                 S18 
                 RPS18 
                 L21 
                 RPL21 
               
               
                   
                 S19 
                 RPS19 
                 L22 
                 RPL22 
               
               
                   
                 S20 
                 RPS20 
                 L23 
                 RPL23 
               
               
                   
                 S21 
                 RPS21 
                 L23A 
                 RPL23A 
               
               
                   
                 S23 
                 RPS23 
                 L24 
                 RPL24 
               
               
                   
                 S24 
                 RPS24 
                 L26 
                 RPL26 
               
               
                   
                 S25 
                 RPS25 
                 L27 
                 RPL27 
               
               
                   
                 S26 
                 RPS26 
                 L27A 
                 RPL27A 
               
               
                   
                 S27 
                 RPS27 
                 L28 
                 RPL28 
               
               
                   
                 S27A 
                 RPS27A 
                 L29 
                 RPL29 
               
               
                   
                 S28 
                 RPS28 
                 L30 
                 RPL30 
               
               
                   
                 S29 
                 RPS29 
                 L31 
                 RPL31 
               
               
                   
                 S30 
                 RPS30 
                 L32 
                 RPL32 
               
               
                   
                   
                   
                 L34 
                 RPL34 
               
               
                   
                   
                   
                 L35 
                 RPL35 
               
               
                   
                   
                   
                 L35A 
                 RPL35A 
               
               
                   
                   
                   
                 L36 
                 RPL36 
               
               
                   
                   
                   
                 L36A 
                 RPL36A 
               
               
                   
                   
                   
                 L37 
                 RPL37 
               
               
                   
                   
                   
                 L37A 
                 RPL37A 
               
               
                   
                   
                   
                 L38 
                 RPL38 
               
               
                   
                   
                   
                 L39 
                 RPL39 
               
               
                   
                   
                   
                 L40 
                 RPL40 
               
               
                   
                   
                   
                 L41 
                 RPL41 
               
               
                   
                   
                   
                 LP0 
                 RPLP0 
               
               
                   
                   
                   
                 LP1 
                 RPLP1 
               
               
                   
                   
                   
                 LP2 
                 RPLP2 
               
               
                   
                   
                   
                 LP3 
               
               
                   
                   
               
             
          
         
       
     
         [0045]    The one or more components of the riboproteome can also be a protein that is a known translation-associated protein including, for example, initiation and elongation factors, and proteins that are conserved across various species and cell lines, such as those listed in Table 4. 
         [0000]                                                        TABLE 4                   Conserved Riboproteome Components            Number   IPI.Prot   GeneSymbol   DAVID.Official                    1   IPI00008223   RAD23B   RAD23B       2   IPI00218918   ANX1   ANXA1       3   IPI00017334   PHB   Phb       4   IPI00008527   RPLP1   rplp1       5   IPI00169383   MIG10   PGK1       6   IPI00553185   CCT3   Cct3       7   IPI00376005   EIF5A   eif5a       8   IPI00015018   IOPPP   PPA1       9   IPI00154975   DNAJC9   dnajc9       10   IPI00100160   CAND1   CAND1       11   IPI00024911   C12orf8   ERP29       12   IPI00939304   IPO5   IPO5       13   IPI00219160   RPL34   Rpl34       14   IPI00014197   CDV3   CDV3       15   IPI00007402   IPO7   IPO7       16   IPI00022305   BZW2   BZW2       17   IPI00021405   LMN1   lmna       18   IPI00021187   INO80H   Ruvbl1       19   IPI00002520   SHMT2   SHMT2       20   IPI00017596   MAPRE1   Mapre1       21   IPI00298994   KIAA1027   TLN1       22   IPI00303882   M6PRBP1   PLIN3       23   IPI00909195   C16orf34   HN1L       24   IPI00031691   OK/SW-cl.103   rpl9       25   IPI00298961   CRM1   xpo1       26   IPI00217563   FNRB   Itgb1       27   IPI00220301   AOP2   Prdx6       28   IPI00218019   BSG   bsg       29   IPI00465028   hCG_25936   TPI1       30   IPI00216694   PLS3   PLS3       31   IPI00221089   RPS13   rps13       32   IPI00299571   PDIA6   pdia6       33   IPI00301263   CAD   cad       34   IPI00215911   APE   Apex1       35   IPI00001757   HSPC114   RBM8A       36   IPI00013122   CDC37   cdc37       37   IPI00099550   DA41   Ubqln1       38   IPI00900293   FLNB   FLNB       39   IPI00009342   IQGAP1   IQGAP1       40   IPI00022648   EIF5   EIF5       41   IPI00218606   RPS23   rps23       42   IPI00294834   ASPH   asph       43   IPI00002460   ANX7   Anxa7       44   IPI00021700   PCNA   pcnA       45   IPI00023860   NAP1L1   NAP1L1       46   IPI00006579   COX4   COX4I1       47   IPI00024067   CLH17   CLTC       48   IPI00031461   GDI2   GDI2       49   IPI00550020   PTMS   PTMS       50   IPI00376798   RPL11   rpl11       51   IPI00008240   MARS   mars       52   IPI00216691   PFN1   pfn1       53   IPI00549725   CDABP0006   pgam1       54   IPI00419258   HMG1   HMGB1       55   IPI00219077   LTA4   LTA4H       56   IPI00020984   CANX   Canx       57   IPI00220835   SEC61B   SEC61B       58   IPI00007765   GRP75   HSPA9       59   IPI00219156   RPL30   RpL30       60   IPI00789551   MATR3   MATR3       61   IPI00017448   RPS21   rps21       62   IPI00185919   KIAA0731   LARP1       63   IPI00003918   RPL1   rpl4       64   IPI00022462   TFRC   TFRC       65   IPI00220642   YWHAG   YWHAG       66   IPI00470498   CGI-55   serbp1       67   IPI00140420   SND1   SND1       68   IPI00009943   RP11-290D2.1-004   TPT1       69   IPI00221222   PC4   sub1       70   IPI00883857   HNRNPU   Hnrnpu       71   IPI00220362   HSPE1   HSPE1       72   IPI00012442   G3BP   G3BP1       73   IPI00302927   CCT4   cct4       74   IPI00010796   ERBA2L   p4hb       75   IPI00025252   ERP57   PDIA3       76   IPI00025512   HSP27   Hspb1       77   IPI00299000   EBP1   PA2G4       78   IPI00328753   CG1   Ktn1       79   IPI00396485   EEF1A   EEF1A1       80   IPI00021812   AHNAK   ahnak       81   IPI00025091   RPS11   rps11       82   IPI00479191   HNRNPH1   Hnrnph1       83   IPI00396321   LRRC59   LRRC59       84   IPI00555744   RPL14   rpl14       85   IPI00795671   hCG_1744585   Ran       86   IPI00010740   PSF   sfpq       87   IPI00873899   ABC50   ABCF1       88   IPI00783872   CAPRIN1   Caprin1       89   IPI00008433   RPS5   Rps5       90   IPI00216298   TRDX   TXN       91   IPI00020599   CALR   CALR       92   IPI00163187   FAN1   fscn1       93   IPI00646304   CYPB   ppiB       94   IPI00009904   ERP70   Pdia4       95   IPI00479786   FUBP2   khsrp       96   IPI00290279   ADK   adk       97   IPI00953576   IGF2BP2   Igf2bp2       98   IPI00013894   STIP1   stip1       99   IPI00642904   hCG_2031827   PABPC4       100   IPI00333541   FLN   FLNA       101   IPI00219678   EIF2A   EIF2S1       102   IPI00306332   RPL24   rpl24       103   IPI00027107   TUFM   Tufm       104   IPI00029012   EIF3A   eif3a       105   IPI00783271   LRP130   lrpprc       106   IPI00014263   EIF4H   eif4h       107   IPI00219153   RPL22   rpl22       108   IPI00414676   HSP90AB1   HSP90AB1       109   IPI00009328   DDX48   Eif4a3       110   IPI00219155   RPL27   Rpl27       111   IPI00514856   KIAA0144   Ubap2l       112   IPI00219446   PBP   PEBP1       113   IPI00550021   OK/SW-cl.32   RPL3       114   IPI00008524   PAB1   PABPC1       115   IPI00399265   hCG_22755   TPD52L2       116   IPI00010153   RPL23   rpl23       117   IPI00301936   ELAVL1   ELAVL1       118   IPI00926625   ZYX   ZYX       119   IPI00016610   PCBP1   Pcbp1       120   IPI00915363   RPS24   RPS24       121   IPI00183626   hCG_20560   Ptbp1       122   IPI00011253   OK/SW-cl.26   rps3       123   IPI00026781   FAS   FASN       124   IPI00396378   HNRNPA2B1   HNRNPA2B1       125   IPI00645078   A1S9T   Uba1       126   IPI00304596   NONO   nonO       127   IPI00020956   HDGF   hdgf       128   IPI00465361   BBC1   RPL13       129   IPI00024157   FKBP25   FKBP3       130   IPI00017617   DDX5   DDX5       131   IPI00025874   RPN1   RPN1       132   IPI00029731   GIG33   RpL35A       133   IPI00848226   GNB2L1   GNB2L1       134   IPI00000874   PAGA   PRDX1       135   IPI00013917   RPS12   rps12       136   IPI00219219   LGALS1   LGALS1       137   IPI00291006   MDH2   mdh2       138   IPI00186290   EEF2   Eef2       139   IPI00012069   DIA4   nqo1       140   IPI00843975   EZR   EZR       141   IPI00027626   CCT6   cct6a       142   IPI00171903   HNRNPM   hnrnpm       143   IPI00604620   NCL   ncl       144   IPI00003865   HSC70   HSPA8       145   IPI00026202   RPL18A   RpL18A       146   IPI00465248   ENO1   eno1       147   IPI00031812   NSEP1   ybx1       148   IPI00029744   SSBP   SSBP1       149   IPI00440493   ATP5A   Atp5a1       150   IPI00141318   CKAP4   Ckap4       151   IPI00001159   GCN1L1   gcn1l1       152   IPI00419979   PAK2   Pak2       153   IPI00013452   EPRS   eprs       154   IPI00022744   CAS   CSE1L       155   IPI00856098   RRBP1   RRBP1       156   IPI00022774   VCP   Vcp       157   IPI00298547   PARK7   PARK7       158   IPI00937615   EEF1G   tut1       159   IPI00029601   CTTN   cttn       160   IPI00303476   ATP5B   ATP5B       161   IPI00011200   PGDH3   PHGDH       162   IPI00647915   CDABP0035   TAGLN2       163   IPI00219365   MSN   msn       164   IPI00796333   ALDA   ALDOA       165   IPI00215780   RPS19   rps19       166   IPI00019502   MYH9   MYH9       167   IPI00643920   TKT   tkt       168   IPI00018146   YWHAQ   ywhaq       169   IPI00001639   KPNB1   KPNB1       170   IPI00215790   RPL38   RPL38       171   IPI00305064   CD44   CD44       172   IPI00456758   RPL27A   RPL27A       173   IPI00007423   ANP32B   anp32b       174   IPI00219301   MACS   MARCKS       175   IPI00219217   LDHB   ldhb       176   IPI00010182   DBI   DBI       177   IPI00216318   YWHAB   YWHAB       178   IPI00952583   MDH1   Mdh1       179   IPI00012750   RPS25   RPS25       180   IPI00414860   RPL37A   RPL37A       181   IPI00026271   PRO2640   rps14       182   IPI00060181   EFHD2   Efhd2       183   IPI00020436   RAB11B   RAB11B       184   IPI00793199   ANX4   anxa4       185   IPI00003949   BLU   UBE2N       186   IPI00000684   SPAG2   UAP1       187   IPI00216026   VDAC2   vdac2       188   IPI00219344   BDR1   hpcal1       189   IPI00479997   LAP18   STMN1       190   IPI00165393   ANP32E   ANP32E       191   IPI00024933   RPL12   RPL12P6       192   IPI00000643   BAG2   BAG2       193   IPI00382470   HSP90A   HSP90AA2       194   IPI00419585   CYPA   PPIAL3       195   IPI00784154   HSP60   HSPD1P6       196   IPI00412607   RPL35   RPL35P2       197   IPI00028635   RPN2   Rpn2       198   IPI00216237   RPL36   RPL36P14       199   IPI00007797   FABP5   FABP5L8       200   IPI00419919   RPL29   RPL29P11       201   IPI00784090   C21orf112   CCT8P1       202   IPI00008530   RPLP0   RPLP0P6       203   IPI00646689   TXNDC17   Txndc17       204   IPI00008274   CAP   CAP1       205   IPI00291467   ANT3   SLC25A6       206   IPI00221035   BTF3   BTF3L1       207   IPI00008494   ICAM1   ICAM1       208   IPI00021428   ACTA   ACTA1       209   IPI00013890   HME1   SFN       210   IPI00016342   RAB7   RAB7A       211   IPI00013004   C21orf124   pdxK       212   IPI00221093   RPS17   rps17       213   IPI00178440   EEF1B   Eef1b2       214   IPI00005202   DG6   PGRMC2       215   IPI00026105   SCP2   SCP2       216   IPI00028031   ACADVL   ACADVL       217   IPI00239077   HINT   HINT1       218   IPI00828150   SUGT1   Sugt1       219   IPI00305383   UQCRC2   Uqcrc2       220   IPI00873344   TPD52   TPD52       221   IPI00289499   ATIC   ATIC       222   IPI00018206   GOT2   Got2       223   IPI00026546   PAFAH1B2   Pafah1b2       224   IPI00470528   EC45   RPL15P18       225   IPI00927658   PP9932   SNORA7B       226   IPI00827535   PTMA   PTMAP4       227   IPI00413108   LAMBR   RPSAP19       228   IPI00182289   RPS29   RPS29P11       229   IPI00013296   D6S218E   RPS18P12       230   IPI00013485   RPS2   RPS2P17       231   IPI00479058   RIG   RPS15P5       232   IPI00293276   GLIF       233   IPI00973811   TBCA       234   IPI00955848   hCG_1739142       235   IPI00893918   DAAP-21F2.2-001       236   IPI00984795   CFL       237   IPI00815770   SNX3   snx3       238   IPI00303318   BM-009   FAM49B       239   IPI00880007   MAP4       240   IPI00983068   GRIM12       241   IPI00719622   RPS28       242   IPI00009946   TOMM34   TOMM34       243   IPI00024915   ACR1   Prdx5       244   IPI00746165   WDR1   wdr1       245   IPI00026215   FEN1   FEN1       246   IPI00479905   NDUFB10   NDUFB10       247   IPI00026337   RANBP3   RANBP3       248   IPI00029557   GREPEL1   GRPEL1       249   IPI00018465   CCT7   Cct7       250   IPI00297779   99D8.1   CCT2       251   IPI00010896   CLIC1   CLIC1       252   IPI00032826   FAM10A1   LOC729992       253   IPI00013949   SGT   Sgta       254   IPI00438229   KAP1   TRIM28       255   IPI00018352   UCHL1   Uchl1       256   IPI00215914   ARF1   Arf1       257   IPI00790342   RPL6   RPL6P27       258   IPI00221088   RPS9   RPS9P4       259   IPI00947127   LDHA   LdhA       260   IPI00017672   NP   pnp       261   IPI00247583   RPL21   RPL21P14       262   IPI00013415   RPS7   RPS7P10       263   IPI00221091   OK/SW-cl.82   RPS15AP12       264   IPI00010810   ETFA   etfA       265   IPI00334190   HSPC108   Stoml2       266   IPI01020905   RPL18       267   IPI00985353   EEF1D       268   IPI00025491   DDX2A   EIF4A1P4       269   IPI00221092   RPS16   RPS16P10       270   IPI00018931   MEM3   Vps35       271   IPI00013895   MLN70   S100A11       272   IPI00329801   ANX5   ANXA5       273   IPI00744692   TAL   taldo1       274   IPI00550746   NUDC   nudC       275   IPI00299149   SMT3B   SUMO3       276   IPI00549343   SYB3   vamp3       277   IPI00027463   CACY   S100A6       278   IPI00290566   CCT1   TCP1       279   IPI00026154   G19P1   prkcsh       280   IPI00303207   ABCE1   ABCE1       281   IPI00011229   CPSD   CTSD       282   IPI00218733   SOD1   SOD1       283   IPI00027252   BAP   PHB2       284   IPI00026328   TLP19   TXNDC12       285   IPI00219913   TGT   USP14       286   IPI00017704   CLP   cotl1       287   IPI00397571   NSFL1C   nsfl1c       288   IPI00001960   CLIC4   CLIC4       289   IPI00554737   PPP2R1A   PPP2R1A       290   IPI00000816   YWHAE   LOC440917       291   IPI00029997   PGLS   pgls       292   IPI00105598   PSMD11   Psmd11       293   IPI00237884   AKAP12   AKAP12       294   IPI00025796   NDUFS3   ndufs3       295   IPI00220766   GLO1   GLO1       296   IPI00029133   ATP5F1   ATP5F1       297   IPI00024993   ECHS1   Echs1       298   IPI00789155   CALU   CALU       299   IPI00003815   ARHGDIA   ARHGDIA       300   IPI00000877   GRP170   hyou1       301   IPI00014230   C1QBP   c1qbp       302   IPI00414127   RANBP1   RanBP1       303   IPI00025849   ANP32A   LOC723972       304   IPI00216746   HNRNPK   LOC644063       305   IPI00644127   IARS   iars       306   IPI00216008   G6PD   G6PD       307   IPI00307162   VCL   vcl       308   IPI00220827   PTMB10   TMSB10       309   IPI00018398   PSMC3   psmc3       310   IPI00549248   NPM   LOC399804       311   IPI00103994   KIAA1352   LARS       312   IPI00216319   YWHA1   YWHAH       313   IPI00021805   GST12   mgst1       314   IPI00215687   GLS   GLS       315   IPI00025366   CS   CS       316   IPI00640817   AK1   ak1       317   IPI00218693   APRT   Aprt       318   IPI00412579   NEDD6   RPL10AP9       319   IPI00003362   GRP78   LOC400750       320   IPI00216308   VDAC   VDAC1P1       321   IPI00012197   CDA03   DCTPP1       322   IPI00219018   CDABP0047   LOC100133042       323   IPI00217030   CCG2   RPS4XP13       324   IPI00026302   RPL31   RPL31P17       325   IPI00021266   RPL23A   RPL23AP65       326   IPI00021840   OK/SW-cl.2   RPS6P25       327   IPI00299573   RPL7A   RPL7AP30       328   IPI00655650   RPS26   RPS26P8       329   IPI00012772   RPL8   RPL8P2       330   IPI00419880   FTE1   LOC100130107       331   IPI00027270   RPL26   RPL26P33       332   IPI00025329   RPL19   RPL19P12       333   IPI00479186   OIP3   LOC652797       334   IPI00304612   RPL13A   RPL13AP7       335   IPI00000494   MSTP030   RPL5P34       336   IPI00008438   RPS10   RPS10P7       337   IPI00216587   OK/SW-cl.83   RPS8P10       338   IPI00030179   RPL7   RPL7P20       339   IPI00179330   RPS27A   RPS27AP11       340   IPI00604590   hCG_2001850   NME2       341   IPI00008529   D11S2243E   RPLP2P3       342   IPI00219953   CMK   CMPK1       343   IPI00395887   PSEC0085   tmx1       344   IPI00219757   FAEES3   GSTP1       345   IPI00418169   ANX2   ANXA2P1       346   IPI00398009   IMP4B   IPO4       347   IPI00297579   CBX3   LOC644101       348   IPI00017592   LETM1   LETM1       349   IPI00291928   RAB14   Rab14       350   IPI00025086   COX5A   COX5A       351   IPI00075248   CALM   CALM3       352   IPI00219078   ATP2A2   ATP2A2       353   IPI00295386   CBR   Cbr1       354   IPI00982652   FAU       355   IPI00010105   EIF3A       356   IPI00977661   RPL17       357   IPI00007611   ATP5O       358   IPI01009955   BCAP31       359   IPI01019113   OK/SW-cl.56       360   IPI00797126   HSD48       361   IPI00006865   SEC22B       362   IPI00171438   TLP46       363   IPI01022506   EIF4B                    
Screening Assays to Identify One or More Compounds that Modulate the Association Between the Target and Component of the Riboproteome
 
         [0046]    As discussed above, we have discovered that riboproteomic genes are frequently amplified in cancer. Based on these discoveries, the association between the target and the component of the riboproteome (e.g., including but not limited to those targets that bind to the components of the riboproteome directly or targets that interact with the component of the riboproteome by an interaction that is mediated by another macromolecule, (e.g., another protein or enzyme)) can be monitored as a way to identify candidate compounds that modulate, alter, increase or decrease (e.g., by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, or more) the association between the one or more targets and one or more components of the riboproteome. Compounds that modulate, alter, decrease, or increase the association between the one or more targets and the one or more components of the riboproteome can be used for the treatment or prevention of a cancer resulting from the change in the level of association between the target and the component of the riboproteome, e.g., prostate adenocarcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma and any other conditions described herein. 
         [0047]    In particular examples, candidate compounds having one or more of the following properties are considered modulators of the association between the target and the component of the riboproteome: decreased association between the target and the component of the riboproteome (e.g., from 3-fold to 4-fold decreased association), decreased expression of the target or the component of the riboproteome, decrease activity of the target or the component of the riboproteome, increased association between the target and the component of the riboproteome, increased expression of the target or the component of the riboproteome, or increased activity of the target or the component of the riboproteome, as compared to a control or a normal reference. Candidate compounds can be tested for their effect on modulation of the association between the target and the component of the riboproteome using assays known in the art. 
         [0048]    Candidate compounds can also be tested for their modulation in the association between the target and the component of the riboproteome using any particular cell based assays described herein. Standard methods may be used to measure analyte levels or cellular parameters in any bodily fluid, including, but not limited to, urine, blood, serum, plasma, saliva, or cerebrospinal fluid. Such methods include immunoassay, ELISA, Western blotting using antibodies directed to one or more targets or one or more components of the riboproteome and quantitative enzyme immunoassay techniques. ELISA assays are the preferred method for measuring polypeptide levels. Accordingly, the measurement of antibodies specific to one or more targets or one or more components of the riboproteome in a subject may also be used to determine if a compound has effects on modulating the association between the target and the component of the riboproteome. 
         [0049]    In one embodiment, a compound that affects the association between the target and the component of the riboproteome may show a decrease in the expression of a nucleic acid encoding the target or the component of the riboproteome. Methods for detecting such alterations are standard in the art. In one example Northern blotting or real-time PCR is used to detect mRNA levels. 
         [0050]    In another embodiment, hybridization techniques may be used to monitor expression levels of a gene encoding the target or the component of the riboproteome upon treatment with a candidate compound. 
         [0051]    In a further embodiment, a reporter gene such as a gene encoding GFP or luciferase can be fused to the target or the component of the riboproteome to monitor the expression levels of the target or the component of the riboproteome upon treatment with a candidate compound. 
         [0052]    In general, candidate compounds are identified from large libraries of both natural product or synthetic (or semi-synthetic) extracts, chemical libraries, or from polypeptide or nucleic acid libraries, according to methods known in the art. Those skilled in the field of drug discovery and development will understand that the precise source of test extracts or compounds is not critical to the screening procedure(s) of the invention. 
       Diagnostic Methods 
       [0053]    The level of association between one or more targets and one or more components of the riboproteome can be used for the diagnosis of a particular type of cancer (e.g., the cancers resulting from a change in the level of association between the target and the component of the riboproteome, a cancer as described herein), or a risk of developing a cancer. The level of association between one or more targets and one or more components of the riboproteome can also be used to monitor the therapeutic efficacy of one or more compounds, including compounds identified or described herein, used to treat a cancer described herein. 
         [0054]    The overall riboproteome profile obtained from a subject can also be used for diagnostic or prognostic purposes. Furthermore, combinations of specific proteins and examination of the global landscape of the one or more targets associated with the one or more components of the riboproteome can be predictive of the outcome or response to treatment with the compounds identified or described herein. For example, amplification, appearance, or disappearance in a gene, protein, combinations of genes, or combinations of proteins found in the riboproteome profile when compared to a normal reference may represent indicators that can help to classify and/or stratify specific patient subgroups that in turn can provide a diagnosis and/or prognosis for treatment of a cancer resulting from a change in the level of association between the target and the component of the riboproteome. 
         [0055]    Standard methods may be used to measure analyte levels or cellular parameters in any bodily fluid, including, but not limited to, urine, blood, serum, plasma, saliva, or cerebrospinal fluid. Such methods include use of mass spectrometry, UV absorption spectroscopy, fluorescence spectroscopy, and quantitative enzyme kinetics techniques. 
         [0056]    Diagnostic methods can include measurement of absolute levels of the one or more targets or the one or more components of the riboproteome as an indirect read out of the change in the level of association between the target and the component of the riboproteome. In any of the diagnostic methods, the level of the target or component of the riboproteome, can be measured at least two different times from the same subject and an alteration in the levels (e.g., by 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or more) over time is used as an indicator of a change in the level of association between the target and the component of the riboproteome and therefore an indicator of a particular type of cancer, or propensity to develop the same. It will be understood by the skilled artisan that for diagnostic methods that include comparing of the level of association between the target and the component of the riboproteome, to a reference level, particularly a prior sample taken from the same subject, a change over time with respect to the baseline level can be used as a diagnostic indicator of a change in the level of association and thus an indicator of a particular type of cancer, or a predisposition to develop the same. The diagnostic methods described herein can be used individually or in combination with any other diagnostic method described herein for a more accurate diagnosis of the presence of, severity of, or predisposition to a particular type of cancer resulting from the change in the level of association between the target and the component of the riboproteome. 
       Compounds 
       [0057]    For any of the methods described herein, the compound identified can be a chemotherapeutic agent (e.g., arsenic trioxide, cisplatin, carboplatin, chlorambucil, melphalan, nedaplatin, oxaliplatin, triplatin tetranitrate, satraplatin, imatinib, nilotinib, dasatinib, and radicicol, e.g., cisplatin), an immunomodulatory agent (e.g., methotrexate, leflunomide, cyclophosphamide, cyclosporine A, minocycline, azathioprine, an antibiotic (e.g., tacrolimus), methylprednisolone, a corticosteroid, a steroid, mycophenolate mofetil, rapamycin, mizoribine, deoxyspergualin, brequinar, a T cell receptor modulator, and a cytokine receptor modulator, e.g., methotrexate), an antiangiogenic agent (e.g., alitretinoin, beloranib, bevacizumab, cetuximab, endostatin (e.g., recombinant forms thereof), erlotinib, etrathiomolybdate, everolimus, imiquimod, interferon alfa (e.g., recombinant forms thereof), itraconazole, lenalidomide, pazopanib, sorafenib, sunitinib, suramin, temsirolimus, thalidomide, tivozanib, vandetanib, and vatalanib), a mitotic inhibitor (e.g., paclitaxel, vinorelbine, docetaxel, abazitaxel, ixabepilone, larotaxel, ortataxel, tesetaxel, vinblastine, vincristine, vinflunine, and vindesine, e.g., paclitaxel), a nucleoside analog (e.g., gemcitabine, azacitidine, capecitabine, carmofur, cladribine, clofarabine, cytarabine, decitabine, floxuridine, fludarabine, fluorouracil, mercaptopurine, pentostatin, tegafur, and thioguanine, e.g., gemcitabine), a DNA intercalating agent (e.g., doxorubicin, actinomycin, bleomycin, mitomycin, and plicamycin, e.g., doxorubicin), a topoisomerase analog (e.g., irinotecan, aclarubicin, amrubicin, belotecan, camptothecin, daunorubicin, epirubicin, etoposide, idarubicin, mitoxantrone, pirarubicin, pixantrone, rubitecan, teniposide, topotecan, valrubicin, and zorubicin, e.g., irinotecan), an antibody (e.g., monoclonal antibodies, such as alemtuzumab, bevacizumab, brentuximab vedotin, catumaxomab, cetuximab, denosumab, edrecolomab, ertumaxomab, gemtuzumab ozogamicin, ibritumomab, ibritumomab tiuxetan, ipilimumab, ofatumumab, panitumumab, rituximab, tositumomab, trastuzumab, as well as radiolabeled forms thereof, or any described herein), a cytokine (e.g., recombinant interferon alpha, interferon beta, interferon gamma, interleukin 2, interleukin 11, granulocyte colony-stimulating factor (G-CSF) and pegylated forms thereof, granulocyte macrophage colony-stimulating factor (GM-CSF), and methionyl human stem cell factor (SCF), as well as any described herein), a folate antimetabolite (e.g., pemetrexed, aminopterin, methotrexate, pralatrexate, and raltitrexed, e.g., pemetrexed), or other targeting agents (e.g., agents that target particular enzymes or proteins involved in cancer or agents that target particular organs or types of cancers), and combinations thereof. 
         [0058]    For any of the methods described herein, the compound identified can also be an inhibitor of metabolic proteins. For example, the compound can be a hexokinase inhibitor (e.g., a hexokinase 2 (HK2) inhibitor (e.g., 2-deoxyglucose, halogenated derivatives of 2-deoxyglucose (e.g., 2-fluorodeoxyglucose), 5-thioglucose, 3-bromopyruvate (3-BrPA), 3-bromo-2-oxopropionate-1-propylester (3-BrOP), lonidamine, imatinib, meclofenoxate, O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate, 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, antisense RNA, N-terminal oligopeptide of hexokinase II (e.g., MIASHLLAYFFTELN-amide (hexokinase II VDAC binding domain peptide; HXK2VBD) and RQIKIWFQNRRMKWKKMIASHLLAYFFTELN-amide), antifungal derivatives (e.g., clotrimazole and bifonazole), and D-mannoheptulose); a lactate dehydrogenase inhibitor (e.g., a lactate dehydrogenase A (LDH-A) inhibitor or a lactate dehydrogenase 5 (LDH-5) inhibitor (e.g., oxamate, gossypol, 3-hydroxyisoxazole-4-carboxylic acid (H ICA), 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid (HTCA), 3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid (FX11), 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, cyclosporine, lindane, antisense RNA (e.g., shRNA, nt 204-232 (L1, gattaca gttgttgggg ttggtgctgt tg), nt 737-765 (L2, tgtg gagtggtgtg aatgttgccg gcgtc), and nt 1161-1188 (L3, tcactgtcca ggctgcagca gggcttct) of NCBI Reference Sequence: NM — 010699)), 1-hydroxy-5-phenyl-1H-indole-2-carboxylic acid, 1-hydroxy-6-phenyl-1H-indole-2-carboxylic acid, and 1-hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic acid); a phosphofructokinase 2 or phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2/PFKFB3) inhibitor (e.g., 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one); a pyruvate kinase M2 (PKM2) inhibitor (e.g., 4R,7S,10R,13S,16R)-7-(4-aminobutyl)-N-[(3R)-1-amino-3-hydroxy-1-oxobutan-2-yI]-16-[[(2R)-2-amino-3-phenylpropanoyl]amino]-13-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide (TLN-232/CAP-232), shikonin, and alkannin); a transketolase inhibitor (e.g., a transketolase-like enzyme 1 (TKTL1) inhibitor (e.g., oxythiamine and furazolidone)); a pyruvate dehydrogenase (PDH) inhibitor (e.g., oxythiamine); a pyruvate dehydrogenase kinase (PDK) inhibitor (e.g., dichloroacetate); a glucose-6-phosphate dehydrogenase (G6PG) inhibitor (e.g., 6-aminonicotinamide, imatinib, 2,2′-azobis(2-amidinopropane), 2,5-dihydroxybenzoic acid, aluminum phosphide, arjunolic acid, benzo(a)pyrene, benzoyl peroxide, calphostin C, cycloartenol, dactinomycin, dexamethasone, diethylnitrosamine, endosulfan, fenvalerate, ferric nitrilotriacetate, ferrous sulfate, glyoxylic acid, furantoin, phenobarbitol, quercetin, isotretinoin, and streptozocin); a GLUT inhibitor (e.g., fluorodeoxyglucose, including radiolabelled forms ([18F]-fluorodeoxyglucose), 2-deoxyglucose, phloretin, and silybin/silibinin); a proton transport inhibitor, such as a carbonic anhydrase-9 (CA9) inhibitor, a membrane-bound V-ATPase inhibitor, and a sodium-proton exchanger 1 (NH E1) inhibitor (e.g., paclitaxel, acetazolamide, cariporide, indisulam, girentuximab, esomeprazole, amiloride and derivatives thereof (5-(N-ethyl-Nisopropyl)amiloride (EIPA)); a monocarboxylate transporter (MCT) inhibitor, such as MCT1, MCT2, MCT3, or MCT4 inhibitors (e.g., α-cyano-4-hydroxycinnamate (CHC), AZD3965, or AR-C117977); a hypoxia-inducible factor 1 alpha (HIF-1 alpha) inhibitor (e.g., BAY87-2243, acriflavine, PX-478, tirapazamine, and an antisense oligonucleotide targeting HIF-1α (EZN-2968, 5′-TGGcaagcatccTGTa-3′, where upper case indicates LNA residues and lower case indicates DNA residues)); a c-Myc inhibitor (e.g., (5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one (10058-F4) and quarfloxin/CX-3453); an AMP-activated protein kinase (AMPK) inhibitor (e.g., metformin); a glutamine inhibitor (e.g., phenylacetate); an asparagine inhibitor (e.g., asparaginase and pegasparaginase); an arginine inhibitor (e.g., arginine deaminase); a fatty acid synthase (FASN) inhibitor (e.g., orlistat, GSK837149A, and C75); and an ATP-citrate lyase (ACLY) inhibitor (e.g., 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid (SB-204990), quercetin, and rutin). 
       Conditions 
       [0059]    In any of the embodiments described herein, the cancer resulting from a change in the level of association between the target and the component of the riboproteome includes non-solid cancers and solid cancers. Exemplary cancers include, but are not limited to leukemia (e.g., chronic myeloid leukemia, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia), adenoid cystic carcinoma, bladder cancer (e.g., adenocarcinoma, sarcoma, small cell carcinoma, squamous cell carcinoma, and transitional cell carcinoma), bladder urothelial carcinoma, brain cancer (e.g., ependymoma, glioma, medulloblastoma, meningioma, teratoid rhabdoid tumor, and teratoma, brain lower grade glioma), breast cancer (e.g., breast ductal carcinoma, breast invasive carcinoma), cervical squamous cell carcinoma and endocervical adenocarcinoma, colon and rectum adenocarcinoma, glioblastoma, glioblastoma multiforme, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver cancer (e.g., hepatocellular carcinoma, cholangiocarcinoma, and hemangioendothelioma), lung cancer (e.g., non-small cell lung cancer, small-cell lung cancer, carcinoid, sarcoma, squamous cell cancer, adenocarcinoma (e.g., papillary adenocarcinoma), lymphoid neoplasm diffuse large b-cell lymphoma, ovarian cancer (e.g., ovarian epithelial carcinoma and teratoma, ovarian serous cystadenocarcinoma), pancreatic adenocarcinoma, prostate adenocarcinoma (e.g., adenocarcinoma and prostatic intraepithelial neoplasia), renal cancer, sarcoma, skin cancer (e.g., basal cell carcinoma, squamous cell carcinoma, and malignant melanoma, skin cutaneous melanoma), stomach adenocarcinoma, testis cancer, thyroid carcinoma, and uterine corpus endometrial carcinoma 
         [0060]    The compounds identified and described herein can also be used to treat cancers having one or more particular mutations that confer resistance to first-line antineoplastic agents. Exemplary cancers having mutations include non-small cell lung cancer having a T790M or a L747S mutation in EGFR kinase, a somatic activating mutation in the tyrosine-kinase pocket of EGFR (e.g., a deletion in exon 19 or a substitution in exon 21, e.g., L858R), or a mutation present in tyrosine kinase inhibitor-resistant cell line H1975; and brain cancer, breast cancer, colorectal cancer, lung cancer, and stomach cancer having a E542K, E545K, H1047R, P539R, or H1047L mutation in the PIK3CA gene (encoding a p110a of class IA of PI3K) (e.g., lung cancer having a H1047R mutation in PIK3CA). 
         [0061]    Other features and advantages of the invention will be apparent from the following description and the claims. 
       EXAMPLES 
     Example 1 
     Experimental Procedures 
     SILAC Labeling and Mass Spectrometry 
       [0062]    Metabolic labeling of prostate cell lines (PC3, PPC1, Du145, RWPE1 and PWR1E) and MEFs was carried out using either normal arginine and lysine or heavier isotopic variants of the two amino acids (L-Lysine 2HCL (U-13C6), L-Arginine HCL (U-13C6, U-N15N4)) (Ong et al., Mol. Cell Proteomics 1:376-386, 2002) using Invitrogen&#39;s SILAC-FLEX Media kits. SILAC labeled protein mixtures were run by SDS-PAGE and gel lanes were cut into 8 sections for overnight digestion at pH 8.0 with modified sequencing grade trypsin (Promega Corp.). Peptide mixtures were eluted and each gel section was analyzed separately by microcapillary liquid chromatography-tandem mass spectrometry (LC-MS/MS) using the EASY-nLC nanoflow HPLC (Thermo Fisher Scientific) with a 75 μm inner diameter×15 cm length Picofrit capillary column (New Objective, Inc.) self-packed with 5 μm Magic C 18  resin (Michrom Bioresources) coupled to a hybrid LTQ Orbitrap XL-ETD mass spectrometer (Thermo Fisher Scientific). The LTQ Orbitrap XL was operated in data-dependent acquisition (DDA) Top 5 mode (1 profile FT-MS spectrum followed by 6 centroided IT-MS/MS spectra). The resolution was 30,000 in FT-MS mode and MS/MS spectra were read out at low resolution in the LTQ XL ion trap. The gradient consisted of 3-38% acetonitrile in 0.1% formic acid (FA) at a flow rate of 300 nL/min for 75 min, 38-95% acetonitrile in 0.1% FA for 2 min and held at 95% acetonitrile in 0.1% FA at for 7 min followed by column re-equilibration for 10 min at 3% acetonitrile in 0.1% FA. MS/MS fragmentation spectra were searched for protein identification using the Andromeda search engine (www.andromeda-search.org) (Cox et al., Proteome Res. 10:1794-1805, 2011) against the reversed and concatenated IPI_HUMAN protein database (v3.87) (http://www.ebi.ac.uk/IPI/IPIhuman.html). Carbamidomethylation of cysteine was set as fixed modification and variable modifications were oxidation of methionine and protein N-acetylation. Raw files for SILAC ratio analysis from each experiment were combined and processed using MaxQuant v1.2.2.5 software (http://www.maxquant.org/) (Cox and Mann, Nat. Biotechnol. 26:1367-1372, 2008). Initial peptide mass tolerance was set to 12 ppm and fragment ion mass tolerance was set to 0.8 Da. Two missed cleavages were allowed and the minimal length required for a peptide was six amino acids. One unique peptide was required for high-confidence protein identifications and a minimum ratio count of two peptides (one unique and one razor) were required for SILAC ratio determination. The peptide and protein false discovery rates (FDR) were set to 0.01. Normalized SILAC ratios (H/L) were used for subsequent analysis. 
       Polysome Isolation and Analysis 
       [0063]    Polysome profiles were prepared from MEF and different prostate cancer cell lines as follows. MEF were seeded at 2×10 6  cells/15 cm and PPC1, PC3, Du145, RWPE1 and PWR1E cells seeded at 10×10 6  cells/15 cm dish and cultured overnight to ensure sub confluent cultures for polysome analysis. PPC1 cells were treated the following day with either DMSO, rapamycin (20 nM) or PP242 (500 nM) for three hours. For polysome preparation, cells were then incubated with cycloheximide at a final concentration of 100 μg/mL for a period of 15 mins. Plates were then washed with ice-cold PBS containing 100 μg/mL cycloheximide (PBS/CHX), scraped, and collected in ice-cold PBS/CHX. Cells were pelleted by centrifugation and subsequently lysed in polysome lysis buffer (20 mM Tris-HCl, pH 7.4; 5 mM MgCl 2 ; 150 mM NaCl; 1% Triton X-100; 1% Deoxycholate; 2.5 mM DTT; 200 U/mL RNasin; 100 μg/mL cycloheximide; 1× complete, EDTA-free protease inhibitor cocktail (Roche); 1× protease inhibitor set (without EDTA) (G-Biosciences); α 1 -antitrypsin (EMD Biosciences) and incubated on ice for 10 min with occasional mixing. Extensive optimization of cell lysis was carried out to identify suitable lysis buffer conditions that completely blocked protein degradation from endogenous proteases, it was necessary to include the extensive array of protease inhibitors provided in the G-Bioscience protease inhibitor set. Lysates were centrifuged at 7,000 rpm for 5 min at 4° C., and the supernatant carefully removed. Protein concentrations for lysates were measured by Bradford assay, and equal amounts of protein loaded on a 15%-50% sucrose gradient containing 100 μg/mL cycloheximide, 0.2 mg/mL heparin and 1 mM DTT. Gradients were centrifuged at 36,000 rpm for 3 hrs at 4° C. in a Beckman SW40 rotor, and subsequently fractionated using an ISCO-Foxy Jr. fraction collector. Polysome profiles were reordered using a UA-6 absorbance detector connected to the fraction collector and measuring absorbance at 254 nm. 
         [0064]    Puromycin-induced polysome dissociation was carried out by the addition of 1 mM puromycin directly to the lysis buffer lacking cycloheximide as previously described (Blobel and Sabatini, Proc Natl Acad Sci USA 68:390-394, 1971; Fuchs et al., J Mol Biol. 410:118-130, 2011). Briefly, following lysis, the samples were incubated at 37° C. for 15 min to dissociate ribosome-mRNA complexes. Lysates were centrifuged at 13,000 rpm for 5 min at 4° C., and the supernatant carefully removed and loaded on a 15%-50% sucrose gradient. Gradients were centrifuged and fractionated as described above. 
       Bioinformatics Analysis of the Riboproteome 
       [0065]    To cluster riboproteome experiments based on the riboproteins identified in each experiment, a Boolean matrix of riboproteome genes by riboproteome experiments was created, in which each entry in the matrix was a 1 if the row&#39;s gene was identified in the column&#39;s experiment, and a 0 otherwise. Clustering of the experiments was then performed using a binary distance measure to compute the distance matrix, and average linkage for hierarchical clustering, implemented with the R functions dist and hclust. 
         [0066]    Venn diagrams indicating membership of riboproteome genes to SILAC experiments were created using the Vennerable package in R. 
         [0067]    To identify functional gene sets enriched in the riboproteome genes, the riboproteome genes were uploaded to Ingenuity Pathway Analysis (www.ingenuity.com) and identified the top biological functions gene sets and canonical pathways gene sets enriched in the riboproteome gene set. To identify KEGG pathways specifically enriched in the subset of riboproteome genes identified in 5 of 5 experiments as compared with the set identified in only 1 of 5 experiments, the 5 of 5 experiments gene list was uploaded to DAVID and used the 1 of 5 experiments gene list as background. Gene ontology analysis was carried out using the online DAVID bioinformatics resource tool. 
       TCGA-Based Analyses of Riboproteome Genomic Alterations Across Human Cancers 
       [0068]    To analyze global patterns of copy number alterations in the riboproteome vs. the background protein-coding genome, the cgdsr package in R was used to download Gistic copy-number alteration calls from the 16 cancer types with available data for a large portion of the riboproteome (between 1661 and 1720 of the riboproteome genes analyzed for each cancer type, median=1675) and the background protein coding genome (19195 genes). For each cancer type, the number of homozygous deletions (GISTIC score=−2), hemizygous deletions (GISTIC score=−1), diploid (GISTIC score=0), low-level copy number gain (GISTIC score=1), and high-level amplification (GISTIC score=2) were recorded among the riboproteome genes and among the background genome. The proportion of each of the GISTIC scores observed among the riboproteome genes to the proportion observed among the background protein-coding genome using the function prop.test in R were compared. To visualize and summarize the distribution of the proportions of alterations across the cancer types, forest plots using the rmeta package were created. 
         [0069]    After characterizing the global properties of riboproteome genomic alterations in human cancers, gene-level analyses was performed. At the time of analysis, the cBio Cancer Genomics Portal contained 5 published data sets and 15 provisional datasets from The Cancer Genome Atlas (TCGA) profiling efforts (Cerami et al., Cancer Discov 2:401-404, 2012). While the 5 published datasets contain mutation data, the provisional TCGA datasets do not. 
         [0070]    These analyses were limited to the 532 riboproteome genes with valid data across 15 TCGA cancer types. For each gene, the proportion of cases of each cancer type that the gene showed homozygous deletion, hemizygous deletion, diploid, low-level amplification, and high-level amplification, based on GISTIC calls downloaded via cgdsr were computed. For each riboproteome gene, the maximum proportion of each type of alteration across the TCGA cancer types was computed. Riboproteome genes and locations of riboproteome genes undergoing frequent amplifications in cancer were visualized with Circos-like plots, implemented using ggplot in R. 
       Western Blot Analysis 
       [0071]    Cells were lysed in lysis buffer containing Complete Mini protease inhibitors (EDTA free) (Roche) and a Phosphatase Inhibitor cocktail (Thermo Scientific). 5-50 μg of total protein was subjected to SDS-PAGE on 4-12% Bis-Tris acrylamide NuPAGE gels in MOPS SDS running buffer (Invitrogen). The following primary antibodies were used: MARCKS, phospho-MARCKS (S152/156), Integrin β1, Calmodulin, Hsp27, Hsp60, RpL13a, RpL7a, and RpS6 (all Cell Signaling), HSP90, (BD Bioscience; BD Transduction Laboratories), hnRNPC1/C2 (Millipore), Rps14 and β-actin (all from Santa Cruz Biotechnologies). The NPM antibody was from DAKO and the IGF2BP3 antibody was from ProteinTech. Subsequently, membranes were incubated with secondary, HRP-tagged antibodies (Amersham) and signals were visualized with ECL or ECL plus (Amersham). It is important to note that Ponceau S staining was used as a control for equal protein loading in the western analysis of polysomal fractions, since typical house keeping genes like β-actin or α-tubulin are not enriched in riboproteome preparations and therefore only barely detectable in polysome fractions ( FIG. 4A ). 
       Example 2 
     High Throughput Analysis of the Riboproteome Using a SILAC-Based Approach 
       [0072]    Without wishing to be bound by theory, the process of active translation within the cell may be regulated by a multitude of proteins that can interact with either the ribosome itself, the mRNAs that are being actively translated, or proteins that may have the capacity to interact with both the ribosome and mRNA. 
         [0073]    In order to characterize the components that constitute the actively translating ribosome (i.e. the riboproteome) mass spectrometry was applied to quantitatively evaluate the protein components that are differentially associated with translation in different cellular contexts, while also allowing for a comprehensive overview of the proteins that make up the riboproteome. 
         [0074]    To this end, relevant cell lines of both mouse (e.g. mouse embryonic fibroblasts (MEFs)) or human origin (e.g. prostate cancer cell lines) were cultured with SILAC media to incorporate amino acids for Light (Lys 0   C13 ; Arg 0   N14 ) or Heavy (Lys 6   C13 ; Arg 10   N15 ) labeling of proteins and proceeded to isolate riboproteome components as outlined in  FIG. 1A . Labeled cells were seeded to ensure sub-confluency at harvesting, and were treated with 100 μg/mL cycloheximide prior to harvesting (see Experimental Procedures). Cells were collected in PBS containing cycloheximide, and equal amounts of cell lysates loaded on 15%-50% sucrose gradients. Polysomes were separated by density gradient centrifugation, and collected by fractionation ( FIG. 1G ). Protein from individual polysome fractions was precipitated by deoxycholate-TCA precipitation, and resuspended in buffer (0.1M Tris pH 8.8; 1% SDS). Precipitated protein from fractions containing polysomes for Heavy and Light labeled cells were combined in a ratio of 1:1 (v/v) and run on an SDS-PAGE gel, which was subsequently stained using Coomassie Brilliant Blue. The gel lane was cut into 8 separate pieces and submitted for analysis by microcapillary liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis on a hybrid linear ion trap-orbitrap mass spectrometer. All resulting MS data were further processed with Mascot or Andromeda and the MaxQuant software suite as previously described in Cox et al., Nat. Biotechnol. 26:1367, 1372, 2008 and Cox et al., Proteome Res. 10:1794-1805, 2011. 
         [0075]    This whole procedure required considerable optimization, as preliminary experiments identified extensive protease activity in polysomal fractions, resulting in degradation to ribosomal components, and affecting quality of mass spectrometry results ( FIG. 1H ). In order, to resolve these issues a comprehensive array of protease inhibitors was employed (as detailed in the Experimental Procedures section), which completely eliminated such protease activity and degradation artifacts. 
         [0076]    To uncover the riboproteomic diversity within cellular populations, this approach was applied to a number of cell systems that included both relevant human prostate cell lines (Du145, PC3, PPC1 prostate cancer cell lines, and the immortalized prostatic epithelial cell lines PWR1E and RWPE1) and mouse embryonic fibroblast cells (MEF) (immortalized Npm1 wild-type and null) as outlined in  FIGS. 1A and 1I . 
         [0077]    Initially, actively translating polysomes from the normal prostatic epithelial cell lines PWR1 E and RWPE1 (two immortalized cell lines routinely used as normal controls for prostate cancer studies) were compared with the metastatic prostate cancer cell line Du145 ( FIG. 1I ). Secondly, the riboproteomes of the prostate cancer cell lines Du145 and PC3 were compared. The use of these four cell lines allowed the evaluation of how the riboproteome changes from a relatively normal situation (PWRE1, RWPE1) to a cancerous state (Du145) and between two different cancer cell lines that harbor distinct genetic alterations (Du145 PTEN wt ; TP53 mut  and PC3 PTEN null ; TP53 null ) ( FIG. 1I ). Thirdly, the riboproteomes of PPC1 prostate cancer cells (PTEN null ; TP53 null ) treated with the mTOR inhibitors rapamycin and PP242 ( FIG. 1I ) were compared. Finally, MEFs harboring wild type or null alleles for the ribosome biogenesis gene Npm1 ( FIG. 1I ) were compared. 
         [0078]    These data allowed, for the first time, determination of the overall composition of the ribosome and its associated proteins, and evaluation of quantitative differences in components of the mammalian riboproteome. Importantly, an initial comparison between polysomes derived from Du145 Heavy and Light labeled cells revealed that all quantified proteins showed an average Log 2  (H/L) ratio of around ‘0’ (226 quantified proteins; Mean 0.0029, STD±0.1866) ( FIG. 1B ) demonstrating that differences observed between cell lines do not arise from variations in sample preparation, and confirming both reliability as well as reproducibility of the technique. 
         [0079]    In further support of this approach as a method to study composition and quantitative differences amongst riboproteomes, a comparison of the two normal and cancer cell line (hereafter referred to as N/C) datasets revealed a substantial overlap in identified proteins from immortalized normal epithelial cell lines, with a significant positive correlation (R 2 =0.4662, p=&lt;0.0001). This demonstrates that these normal cell lines share significant similarity, which in turn gives greater significance to differences that exist between normal and cancer riboproteomes ( FIG. 1C ). 
         [0080]    Importantly, several differences were detected between the riboproteomes of N/C datasets as well as between cancer cell types (hereafter referred to as C/C) using indicated cut-off values (cut-offs are based on two standard deviations from the mean) ( FIGS. 1D ,  1 E and  1 J). These differences are described in greater detail below, and include a variety of proteins including RNA binding proteins (RBPs) (e.g. IGF2BP2, IGF2BP3), cell adhesion molecules (e.g. Integrin β1), and signaling proteins (e.g. MARCKS) amongst others. 
         [0081]    In addition, acute exposure to the mTOR inhibitors rapamycin and PP242 in PPC1 cells reveals that only strong inhibition of the mTOR kinase itself results in a clear perturbation to the riboproteome ( FIGS. 1F and 1K ). This is consistent with the differential capacity of these drugs to inhibit mTOR activity towards translation (DMSO&lt;rapamycin&lt;PP242) with numerous ribosomal proteins and RBPs (e.g. RpL4, RpL6, RpS6, LARP proteins) demonstrating the most striking quantitative differences ( FIGS. 1F and 1K ). 
         [0082]    Comparing Npm1 wild type or null immortalized MEFs, mass spectrometry data from two separate biological replicates were combined, including a label switch. No change in relative quantification of ribosomal proteins was observed between Npm1 wild type and null immortalized MEFs ( FIG. 1L ). Interestingly, Npm1 was identified as the most highly decreased protein in Npm1 null riboproteomes ( FIG. 1L ), due to the presence of N-terminal peptides that remain as a result of the knockout strategy, thereby serving as an internal positive control. 
         [0083]    Notably, the approach identified and quantified all but one (RpL41, a lysine and arginine rich 25 amino acid protein that is unlikely to be identified by this mass spectrometry approach due to the large number of sites available for trypsin cleavage, and the consequent inability to generate multiple peptides) ribosomal proteins ( FIG. 1M ), as well as other known translation-associated proteins including initiation and elongation factors. It was observed that ribosomal proteins of both the small and the large subunit cluster around a normalized Log 2  (H/L)=0 ( FIG. 1N ), indicating that ribosomal proteins are unchanged between normal and cancer cells, as well as between cancer cell lines and genetically defined MEFs. These data make the important point that, at least amongst these cell lines, core ribosomal protein composition in polysomes is not altered. 
       Example 3 
     Characterization of the Riboproteome 
       [0084]    Overall, the number of proteins quantified in each of the individual groups of experiments varied from 575 to 991 ( FIG. 2F ), and offered the potential to uncover significant overlap of proteins that make up the riboproteomic space in mammalian cells. 
         [0085]    To first examine how the datasets compared to one another an unsupervised hierarchical clustering of the 6 conditions was analyzed ( FIG. 2G ). Interestingly, the MEF dataset appeared to cluster independently from the human prostate cancer cells, while amongst the prostate cancer cells, PPC1 cell lines cluster together and the immortalized prostate epithelial cell lines cluster together. The PC3 and Du145 experiments displayed greater similarity to immortalized epithelial cells, likely due to their shared comparison. These data indicate that the riboproteome itself may have the capacity to categorize cell types and tissues based on riboproteomic diversity, and in turn can contribute to regulation of gene expression within a given cellular compartment. 
         [0086]    In addition to a number of significant differences identified between the various samples, the hierarchical clustering clearly demonstrated all prostate cell lines shared high similarity. Thus, these data sets were combined in order to gain a global perspective of the prostate riboproteome. In the combined prostate cell line dataset, a total of 1499 quantified proteins was identified ( FIG. 2A ). Of these 1499 proteins, 70% were identified in at least two experimental datasets, while 24% (363 of 1499) were identified in all 5 experiments ( FIG. 2B ). Indeed, this number of 363 core riboproteomic components represents over 60% of the PC3/Du145 SILAC experiment, which contained the lowest number of proteins identified in the prostate cell line cohort ( FIG. 2F ). It is also interesting to note that 96% of proteins quantified in this PC3/Du145 dataset were found in at least one other dataset, with only 21 proteins quantified unique to this experiment. These data show strong overlap in proteins identified amongst the independent riboproteome experiments, and highlights the advantage of using multiple cell lines to characterize the riboproteome. 
         [0087]    Ingenuity Pathway Analysis (http://www.ingenuity.com/) of all 1499 proteins identified was carried out to examine what (1) biological functions and (2) canonical pathways may be specifically enriched in the dataset. Importantly, biological functions related to protein synthesis, post-translational modification and protein folding were found to be highly enriched in our combined dataset ( FIG. 2I ). In agreement with this, the canonical pathway analysis demonstrated EIF2 signaling, regulation of eIF4 and p70S6K signaling, and mTOR signaling pathways to be significantly represented ( FIG. 2J ). 
         [0088]    In addition, KEGG pathway analysis of proteins identified in all 5 experimental datasets (363/1499) compared to proteins identified in at least 1 experiment (1499) identified ribosome related pathways to be highly enriched ( FIG. 2K ). 
       Example 4 
     Diversity of Protein Functional Groups and Enrichment of RNA Binding Proteins in the Riboproteome 
       [0089]    To better understand the various protein components that make up the riboproteome, DAVID (david.abcc.ncifcrf.gov) (Huang et al., Nat Protoc 4:44-57, 2009) was used to perform a gene ontology-based functional categorization of the proteins identified in the combined dataset ( FIG. 2C ). This analysis demonstrated a clear and significant enrichment in ribosome and translation related processes. In addition, a number of other diverse protein functional groups were found to be included in the riboproteome, including melanosome and glucose catabolic processes. Critically, a significant enrichment of RBPs to be constituents of the riboproteome were identified. As two recent papers published now describe the RNA-binding protein interactome in detail (Baltz et al., Mol Cell 46:674-690, 2012; Castello et al., Proteins Cell 149:1393-1406, 2012), the riboproteome and RBP-interactome datasets were compared to evaluate the proportion of RBPs that form part of the riboproteome. Using the dataset from Castello et al. a considerable overlap between the RBP-interactome and riboproteome ( FIG. 2D ) was found. Strikingly, core riboproteome components show themselves to be enriched in RBP-interactome proteins (50% of proteins identified can be assigned to the RBP-interactome,  FIG. 2E , left panel), while those proteins identified in only one experimental condition have a much lower RBP-interactome component (only 29% of proteins identified can be assigned to the RBP-interactome,  FIG. 2M , left panel). Moreover, it is interesting to note that when the riboproteome RBPs were broken down according to the categories defined by Castello et al. in  FIG. 2L  (i.e. mRNA-Interactome; Candidate RBP; No Evidence), the proportional distribution in these three categories is highly similar to those described by Castello et al. ( FIGS. 2E and 2M , right panels for RBP categories from the riboproteome). 
       Example 5 
     Riboproteomic Genes are Frequently Amplified in Human Cancer 
       [0090]    As cellular proliferation is strongly coupled to translation, the riboproteome was evaluated to see if it may be altered in human cancer using the cBio Cancer Genomics Portal (http://cbioportal.org) and the R package cgdsr, developed at Memorial Sloan-Kettering Cancer Center. 
         [0091]    The distribution of copy number alterations in the riboproteome was examined as compared with genes in the background genome across 16 cancer types. This analysis included between 1661 and 1720 of the riboproteome genes (median=1675) and 19195 non-riboproteome background genes. The overall analysis shows that the riboproteome is enriched for copy-number gains and high-level amplifications ( FIGS. 3A and 3G ) and depleted for hemizygous and homozygous deletions (all P&lt;2.2e −16 ) ( FIGS. 3B and 3H ). 
         [0092]    Based on these data, we sought to identify riboproteomic genes that undergo the most frequent CNA&#39;s in specific cancer types. This analysis focused on 532 riboproteome genes with complete copy number data across 15 cancer types. Riboproteome genes were ranked by the maximum number of cases where they showed a genomic amplification across the 15 cancers ( FIGS. 3C and 3I ). Interestingly, 38 riboproteome genes correlated with high-level amplifications in at least 10% of at least 1 cancer type was observed ( FIG. 3D ). While several genetic loci are represented in this data set including 4p16.3, 1p33 and 19p13, more than half of these genes (60%, 23 of 38) grouped to three specific genetic loci. These loci represented 1q22, 3q26 and 8q24, with regions surrounding chromosome 3q26 and 8q24 identified as showing most frequent amplification ( FIGS. 3C and 3D ). Analysis of the gene signature for the 3q riboproteomic gene locus (9 genes) in the TCGA studies containing mutation data showed that 51% (91 of 178 cases) of lung squamous cell carcinoma contained an alteration in at least one of these genes ( FIG. 3E , left panel). Ovarian serous cyst adenocarcinoma showed alterations of 39% ( FIG. 3E , left panel), while patient samples from other cancer types also showed alterations in this 3q gene set ( FIG. 3E , left panel). Analysis of the same datasets for the 8q riboproteome gene locus, identified breast invasive carcinoma to harbor frequent alterations to genes in this locus (21% of cases, 103 of 482 cases) ( FIG. 3F , left panel). Ovarian serous cyst adenocarcinoma patients also showed significant alteration (38%%, 121 of 316 cases), while prostate cancer patients showed alteration in 13% of patients at this locus (11 of 82 cases ( FIGS. 3F , left panel and  3 K)). Accordingly, closer analysis of 3q26 and 8q24 riboproteome gene groups in individual patients clearly demonstrate frequent co-amplification of these genes, in line with our hypothesis that riboproteomic genes are preferentially amplified in cancer ( FIGS. 3E and 3F , right panels). Similarly, the 1q22 locus demonstrates a frequent amplification in various cancer types ( FIG. 3J ). 
         [0093]    Interestingly, both 3q26 and 8q24 harbor established oncogenes, PIK3CA and MYC respectively. While it may be considered that the riboproteomic genes in these regions may be simply amplified along with the dominant oncogene at the relevant locus, our cBio analysis clearly identifies a number of patients with invasive breast carcinoma without MYC amplification or mutation, while still harboring amplification of 8q24 riboproteome genes ( FIG. 3F , right panel), suggesting that they have the potential to promote tumorigenesis independent of MYC. 
         [0094]    Furthermore, the amplified riboproteomic loci were infrequently co-amplified in a number of cancer types. For example, limited co-occurrence of 3q26 and 1q22 amplification is observed in patients from lung adenocarcinoma and breast invasive carcinoma cancer datasets ( FIGS. 3L and 3M ). 
       Example 6 
     The Riboproteomic Platform for the Identification of Riboproteomic Components and Regulators of Translation 
       [0095]    The differences in N/C cells as well as C/C cells were the next focus to identify riboproteomic components and as a means to validate the approach. As mentioned above, the datasets revealed marked differences in proteins quantified between polysomal fractions of normal and cancer cells (i.e. RWPE1 and PWR1E cells compared to Du145 cells), indicating that the Du145 cancer cells display numerous differences in the composition of their riboproteome ( FIGS. 1D and 1J ). These differences encompass a variety of protein types and include a number of potential ribosome-associated proteins that were reproducibly enriched on the polyribosomes of either normal or cancer cells, including intracellular adhesion molecule 1 (ICAM1), vimentin (VIM) and integrin β1 (ITGB1) that are enriched in cancer cells as well as the RBPs IGF2BP2 and IGF2BP3 that were amongst others reproducibly enriched in normal cells ( FIGS. 4F and 4G ). In order to further establish the relevance of the riboproteome in the context of cancer, we focused on differentially quantified proteins associated with polyribosomes of prostate cancer cells (i.e. PC3 cells compared with Du145 cells) ( FIGS. 1E and 4H ). 
         [0096]    Amongst these differentially quantified proteins MARCKS stood out as it was a highly differential factor ( FIG. 1E  and S4C), and a major cellular substrate for Protein Kinase C (PKC), suggesting that MARCKS might represent a regulator of cellular translation and a candidate for further validation. 
         [0097]    Importantly, MARCKS was strongly associated with polyribosomes of the prostate cancer cell line PC3 when compared to Du145 cells ( FIGS. 4A and 4B ). To further confirm this observation, polysomal fractions from three prostate cancer cell lines (PC3, PPC1 and Du145) were isolated as well as the two normal immortalized-epithelial control cell lines (PWR1E, RWPE1) and subjected pooled polysomal fractions to western blot analysis. Indeed, it was confirmed that PC3 and PPC1 cells displayed increased amounts of MARCKS on polyribosomes when compared to either Du145 or prostatic epithelial cell lines ( FIG. 4B ). In addition, these cells also displayed high levels of phosphorylation of the PKC sensitive serine residues of MARCKS (S159 and S163) ( FIG. 4B ). This analysis also validated the SILAC findings that ribosomal protein levels (e.g. RpS6, RpS14 and RpL7a) remain unaltered between cancer cell lines ( FIG. 4A ). In contrast to MARCKS, the SILAC analysis revealed that integrin β1 was highly enriched in Du145 cells when compared to PC3 cells, and western blot analysis also confirmed this differential enrichment ( FIG. 4A ). 
         [0098]    To extend this validation and analysis further, additional western blot analysis was carried out on lysates from each of the prostate cell lines utilized in this screening. As expected, the presence of all proteins analyzed in the polysomal fractions collected were confirmed ( FIG. 4C ). Additionally, these data confirm the SILAC predictions regarding differential expression of proteins (e.g. compare integrin β1 in PC3 and Du145 lysates, or IGF2BP3 in Du145 and RWPE1 lysates,  FIG. 4C ). 
         [0099]    As an additional validation for polysomal association, a well-established method of puromycin-mediated dissociation of ribosome-mRNA complexes was employed (Blobel and Sabatini, Proc Natl Acad Sci USA 68:390-394, 1971). As shown in  FIG. 4J , puromycin treatment results in the loss of RpS6 and RpL13a from polyribosomes as determined by western blot analysis of pooled polysomal fractions. As an example of a riboproteome component associating with polyribosomes, the presence of MARCKS was also dramatically decreased in polyribosome fractions upon puromycin treatment ( FIGS. 4D and 4J ), which in addition supports the hypothesis that MARCKS plays a role in translation through association with actively translating ribosomes. 
         [0100]    It was hypothesized that the riboproteomic platform would allow for the identification of mechanisms of response to pharmacological perturbation and for translational targets that could be differentially exploited for therapeutic intervention in cancer. 
         [0101]    To this end, riboproteomic analysis upon inhibition of mTOR using the inhibitors rapamycin (a TORC1 inhibitor (Thoreen and Sabatini, Autophagy 5:725-726, 2009)) and PP242 (a mTOR kinase inhibitor that inhibits TORC1 and TORC2 activity simultaneously (Feldman et al., PLoS Biol 7:e38, 2009)) was performed as mentioned above. This analysis revealed that the riboproteome is indeed differentially responsive to treatment modalities. Although, it was found that rapamycin has little impact on the composition of the riboproteome ( FIG. 1K ), the more potent mTOR kinase inhibitor PP242 results in a much stronger and more robust perturbation of the riboproteome ( FIG. 1F ). Indeed, while inhibition of mTOR by PP242 identifies a number of proteins, including some ribosomal proteins (e.g. see RpL4, RpL6 and RpS6 in  FIG. 4I ), that show a rapid and significant disassociation from the riboproteome upon treatment with PP242, this may represent a more general dissociation of the ribosome and a block in translation. Interestingly, the RBP LARP1 (La ribonucleoprotein domain family member 1) appeared to be one of the most dynamic components of the riboproteome in response to mTOR inhibition by PP242 ( FIGS. 1F and 4E ). Although the function of LARP1 is not completely understood, it has been reported to play a role in cell division, apoptosis and migration (Burrows et al., Nucleic Acids Res. 38: 5542-5553, 2010), and it has been shown to be an mTOR sensitive phosphoprotein (Hsu et al., Science 332:1317-1322, 2011; Yu et al., Science 332:1322-1326, 2011). The RNA binding activity of LARP1 was confirmed (Burrows et al., Nucleic Acids Res. 38:5542-5553, 2010), by using a micrococcal nuclease (MN) assay (Darnell et al., Cell 146:247-261, 2011). Pooled sucrose gradient fractions containing LARP1 protein, were treated with and without MN. Ribosomes were subsequently pelleted by ultracentrifugation, and the protein in supernatant and pellet isolated for western blot analysis. As seen in  FIG. 4K , LARP1 behaved similar to the well-characterized poly-A binding protein (PABP). Without MN treatment, LARP1 pelleted with ribosomal proteins, indicating its close association with polysome components. However, upon treatment with MN, LARP1 no longer associated with riboproteome components, and is released into the supernatant similar to PABP ( FIG. 4K ). This indicates that LARP1 is predominantly an RBP, showing limited association with the ribosome itself. In addition, treating cells with PP242 prior to this analysis, it was observed that while PABP appears to remain tightly intact with polysome fractions, there appears to be more LARP1 observed in the supernatant, suggesting that mTOR inhibition can selectively influence binding of LARP1 at the polysome ( FIG. 4L ). Thus, these findings suggest that mTOR activity towards LARP1 may represent an additional means by which mTOR can regulate translation. 
         [0102]    Finally, to examine whether the riboproteome is altered in response to a genetic perturbation, SILAC riboproteomic analysis on Npm1 wild type and null immortalized MEF was analyzed (immortalized by deletion of the Trp53 gene) ( FIG. 1L ). Again, SILAC analysis of polysome fractions demonstrated a high similarity between riboproteome components, with ribosomal proteins themselves showing no quantitative difference between the Npm1 wild type or null MEF preparations ( FIG. 1L ). However, there were a number of proteins that demonstrated differential association with polysomes from Npm1 wild type and null MEFs, which may be relevant for translation in these cells ( FIGS. 1L and 4M ). Interestingly, the heterogeneous nuclear ribonucleoprotein hnRNPC was identified to be one of the most highly increased proteins on the polysomes of Npm1 null MEFs ( FIG. 4N ). 
         [0103]    Thus, taken together these data validate this approach as an effective means to study riboproteome composition in a wide variety of cellular contexts, and highlight this approach as a valuable resource that can be applied to the study of how perturbations to genes and pathways impact the riboproteome. 
       Other Embodiments 
       [0104]    While the invention has been described in connection with specific embodiments thereof, it will be understood that it is capable of further modifications and this application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure come within known customary practice within the art to which the invention pertains and may be applied to the essential features herein before set forth. 
         [0105]    All publications, patents, and patent applications are herein incorporated by reference in their entirety to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated by reference in its entirety.