Abstract:
The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (I), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders.

Description:
INTRODUCTION 
       [0001]    The present invention relates to compounds that are inhibitors of protein kinases, the method of preparation thereof and the therapeutic application thereof. 
         [0002]    Dysfunction/deregulation of protein kinases (PK) is the cause of a large number of pathologies including oncological, immunological, neurological, metabolic and infectious diseases. This has generated considerable interest in the development of small molecules and biological kinase inhibitors for the treatment of these disorders. 
         [0003]    Numerous PK are particularly deregulated during the process of tumorigenesis. Consequently protein kinases are attractive targets for anticancer drugs, including small molecule inhibitors that usually act to block the binding of ATP or substrate to the catalytic domain of the tyrosine kinase and monoclonal antibodies that specifically target receptor tyrosine kinases (RTK) and their ligands. In solid malignancies, it is unusual for a single kinase abnormality to be the sole cause of disease and it is unlikely that tumors are dependent on only one abnormally activated signaling pathway. Instead multiple signaling pathways are dysregulated. Furthermore, even single molecular abnormalities may have multiple downstream effects. Multi targeted therapy using a single molecule (MTKI=“Multi-Targeted Kinase Inhibitors”) which targets several signaling pathways simultaneously, is more effective than single targeted therapy. Single targeted therapies have shown activity for only a few indications and most solid tumors show deregulation of multiple signaling pathways. For example, the combination of a vascular endothelial growth factor receptor (VEGFR) inhibitor and platelet derived growth factor receptor (PDGFR) inhibitor results in a cumulative antitumor efficacy (Potapova et al., Mol Cancer Ther 5, 1280-1289, 2006). 
         [0004]    Tumors are not built up solely of tumor cells. An important part consists of connective tissue or stroma, made up of stromal cells and extracellular matrix, which is produced by these cells. Examples of stromal cells are fibroblasts, endothelial cells and macrophages. Stromal cells also play an important role in the carcinogenesis, where they are characterized by upregulation or induction of growth factors and their receptors, adhesion molecules, cytokines, chemokines and proteolytic enzymes (Hofmeister et al., Immunotherapy 57, 1-17, 2007; Raman et al., Cancer Letters 256, 137-165, 2007; Fox et al., The Lancet Oncology 2, 278-289, 2001) 
         [0005]    The receptor associated tyrosine kinase VEGFR on endothelial and tumor cells play a central role in the promotion of cancer by their involvement in angiogenesis (Cébe-Suarez et al., Cell Mol Life Sci 63, 601-615, 2006). In addition, the growth factors TGF-β, PDGF and FGF2 secreted by cancer cells transform normal fibroblasts into tumor associated fibroblasts, which make their receptors a suitable target for inhibition by kinase inhibitors (Raman et al., 2007). 
         [0006]    Moreover, increasing evidence suggests a link between the EGF receptor (EGFR) and HER2 pathways and VEGF-dependent angiogenesis and preclinical studies have shown both direct and indirect angiogenic effects of EGFR signaling (Pennell and Lynch, The Oncologist 14, 399-411, 2009). Upregulation of tumor pro-angiogenic factors and EGFR-independent tumor-induced angiogenesis have been suggested as a potential mechanism by which tumor cells might overcome EGFR inhibition. The major signaling pathways regulated by EGFR activation are the PI3K, MAPK and Stat pathways that lead to increased cell proliferation, angiogenesis, inhibition of apoptosis and cell cycle progression. EGFR is overexpressed in a wide variety of solid tumors, such as lung, breast, colorectal and cancers of the head and neck (Cook and Figg, C A Cancer J Clin 60, 222-243 2010). Furthermore, higher expression of EGFR has been shown to be associated with metastasis, decreased survival and poor prognosis. 
         [0007]    c-Src, a membrane-associated non receptor tyrosine kinase, is involved in a number of important signal transduction pathways and has pleiotropic effects on cellular function. c-Src integrates and regulates signaling from multiple transmembrane receptor-associated tyrosine kinases, such as the EGFR, PDGFR, IGF1R, VEGFR, HER2. Together, these actions modulate cell survival, proliferation, differentiation, angiogenesis, cell motility, adhesion, and invasion (Brunton and Frame, Curr Opin Pharmacol 8, 427-432, 2008). Overexpression of the protein c-Src as well as the increase in its activity were observed in several types of cancers including colorectal, gastrointestinal (hepatic, pancreatic, gastric and oesophageal), breast, ovarian and lung (Yeatman, Nat Rev Cancer 4, 470-480, 2004). 
         [0008]    The activation in EGFR or KRAS in cancers leads to a greatly enhanced level of Ras-dependent Raf activation. Hence, elimination of Raf function is predicted to be an effective treatment for the numerous cancers initiated with EGFR and KRAS lesions (Khazak et al., Expert Opin. Ther. Targets 11, 1587-1609, 2007). Besides activation of Raf signaling in tumors, a number of studies implicate the activation of the Ras-Raf-MAPK signaling pathway as a critical step in vasculogenesis and angiogenesis. Such activation is induced by growth factor receptors such as VEGFR2, FGFR2 and thus inhibition of Raf activation represents a legitimate target for modulation of tumor angiogenesis and vascularization. 
         [0009]    Although VEGFR, PDGFR, EGFR, c-Src and Raf are important targets on both tumor cells and tumor stroma cells, other kinases such as FGFR only function in stromal cells and other oncogenes often only function in tumor cells. 
         [0010]    Protein kinases are fundamental components of diverse signaling pathways, including immune cells. Their essential functions have made them effective therapeutic targets. Initially, the expectation was that a high degree of selectivity would be critical; however, with time, the use of “multikinase” inhibitors has expanded. Moreover, the spectrum of diseases in which kinase inhibitors are used has also expanded to include not only malignancies but also immune-mediated diseases/inflammatory diseases. The first step in signaling by multi-chain immune recognition receptors is mediated initially by Src family protein tyrosine kinases. MTKI targeting kinases involved in immune function are potential drugs for autoimmune diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel diseases (Kontzias et al., F1000 Medicine Reports 4, 2012) 
         [0011]    Protein kinases mentioned previously are also key components of many other physiological and pathological mechanisms such as neurodegeneration and neuroprotection (Chico et al., Nature Reviews Drug Discovery 8, 892-909, 2009), atherosclerosis, osteoporosis and bone resorption, macular degeneration, pathologic fibrosis, Cystogenesis (human autosomal dominant polycystic kidney disease . . . ). 
         [0012]    In WO2010/092489 and related patents/patent applications, we identified several compounds which exhibited interesting properties for such applications. However, we have discovered that some of these compounds could be enhanced in their properties by selectively working on particular regions of their structures. However, the mechanism of action of these structures on kinases was not precisely elucidated at the time of WO2010/092489&#39;s filing and thus it was unexpectedly that we found the high activities of the structures disclosed in the present application. 
         [0013]    The subject matter of the present invention is to offer novel multi-targeted kinase inhibitors, having an original backbone, which can be used therapeutically in the treatment of pathologies associated with deregulation of protein kinases including tumorigenesis, human immune disorders, inflammatory diseases, thrombotic diseases, neurodegenerative diseases, bone diseases, macular degeneration, fibrosis, cystogenesis. 
         [0014]    The inhibitors of the present invention can be used in particular for the treatment of numerous cancers and more particularly in the case of liquid tumors such hematological cancers (leukemias) or solid tumors including but not limited to squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, gastric cancer, pancreatic cancer, glial cell tumors such as glioblastoma and neurofibromatosis, cervical cancer, ovarian cancer, liver cancer, bladder cancer, breast cancer, melanoma, colorectal cancer, endometrial carcinoma, salivary gland carcinoma, renal cancer, prostate cancer, vulval cancer, thyroid cancer, sarcomas, astrocytomas, and various types of hyperproliferative diseases. 
       SUMMARY OF THE INVENTION 
       [0015]    The present invention relates to compounds of the following formula (I): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0016]    characterized in that,
       R1 is C 1 -C 6  alkyl group, hydroxyl group, or NR 4 R 5 ,   R4 and R5 are independently a hydrogen atom, and/or C 1 -C 6  alkyl group,   X is CH 2 , C(S) or C(O),   R2 is a hydrogen atom, a C 1 -C 6  alkyl group or a halogen atom,   Y is chosen from a group consisting of HNC(O), HNC(S), HNSO 2 , HNC(O)CH 2 , HNC(S)CH 2 , HNC(O)NH, HNC(S)NH, CH 2 NHC(O), C(O)NH and C(O)NHCH 2 , CH 2 NHC(S), preferably HNC(O),   R3 is chosen from a group consisting of:
           an aryl, preferably a phenyl group mono or polysubstituted with:
               a hydroxyl group,   a halogen atom,   a C 1 -C 6  alkyl-amine group, preferably a secondary C 1 -C 6  alkyl-amine,   a C 1 -C 6  alkoxy group,   an amine substituted by a heteroaryl such as thiazol, or imidazol said heteroaryl optionally monosubstituted by a methyl,   a C 1 -C 6  trifluoroalkoxy group, preferably a trifluoromethoxy,   a C 1 -C 6  alkyl group, preferably a methyl or isopropyl,   a C 1 -C 6  trifluoroalkyl group, preferably a trifluoromethyl,
                   a heteroaryl group such as thiazol, or imidazol optionally monosubstituted by a methyl,   
                   an aliphatic heterocycle, optionally substituted by a methyl group, a hydroxyl group, an amine group, —NHCH 3 , or —N(CH 3 ) 2 ,   a C 1 -C 6  alkyl substituted by a heterocycle, wherein said heterocycle is optionally substituted by a methyl group, a hydroxyl group, an amine group, —NHCH 3 , or —N(CH 3 ) 2 , or   the fragment:   
               
               
 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             
               
                 a heteroaryl group preferably chosen from a group consisting of dihydrobenzofuran, indol, benzodioxol, benzotriazol, pyridine optionally substituted with a C 1 -C 6  alkyl group, a C 1 -C 6  trifluoroalkyl group, a halogen atom and/or a hydroxyl, 
                 a non-aromatic monosubstituted cyclic group, preferably a cyclic C 3 -C 10  alkyl, monosubstituted with a hydroxyl, a halogen, a C 1 -C 6  alkyl-amine, a C 1 -C 6  alkoxy, a C 1 -C 6  trifluoroalkoxy a C 1 -C 6  alkyl, a C 1 -C 6  trifluoroalkyl,
 
and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof.
 
               
             
           
         
       
     
         [0038]    Another aspect of the present invention concerns a method of preparation of the compounds as defined herein, characterized in that it comprises at least one of the following steps:
       a) in the case of X being CO, the NH—CO bond is formed by means of peptide coupling techniques of an aromatic carboxylic acid preferably substituted with an NO 2  group, preferably by the use of a carbodiimide or an uronium coupling agent, or in the case of X being CH 2 , the NH—CH 2  bond is formed by a reductive amination with an aromatic aldehyde preferably substituted with an NO 2  group, preferably in the presence of a boron anhydride, and,   b) optional reduction of the NO 2  group into NH 2 , preferably by hydrogenation, such as a catalytic hydrogenation for example in the presence of palladium on charcoal under hydrogen atmosphere.       
 
         [0041]    Another aspect of the present invention concerns a method of preparation of the compounds as defined herein, characterized in that the method comprises at least one of the following steps, preferably after steps (a) and/or (b) of the above method:
       c 1 ) formation of an urea in the case of Y being HNC(O)NH, by reacting the compound obtained after step b) with an isocyanate,   c 2 ) formation of a thiourea in the case of Y being HNC(S)NH, by reacting the compound obtained after step b) with an isothiocyanate,   c 3 ) formation of a sulfonamide in the case of Y being HNSO 2 , by reacting the compound obtained after step b) with a halogen sulfamyl or halogen sulfonyl, such as sulfamyl chloride or sulfonyl chloride,   c 4 ) formation of an amide in the case of Y being HNC(O), preferably by reacting the compound obtained after step b) with an activated carboxylic acid, such as an acyl chloride, or   c 5 ) formation of a thioamide in the case of Y being HNC(S), in particular by reacting the compound obtained after step c4) with the Lawesson&#39;s reagent, and   d) optional saponification of the obtained product, preferably by the use of KOH.       
 
         [0048]    Another aspect of the present invention concerns a method of preparation of the compounds as defined herein, characterized in that the method comprises at least one of the following steps, preferably after steps (a) and/or (b) of the above method:
       c 1 ) formation of an urea in the case of Y being HNC(O)NH, by reacting the compound obtained after step b) with an isocyanate,   c 2 ) formation of a thiourea in the case of Y being HNC(S)NH, by reacting the compound obtained after step b) with an isothiocyanate,   c 3 ) formation of a sulfonamide in the case of Y being HNSO 2 , by reacting the compound obtained after step b) with a halogen sulfamyl or halogen sulfonyl, such as sulfamyl chloride or sulfonyl chloride,   c 4 ) formation of an amide in the case of Y being HNC(O) or HNC(O)CH 2 , preferably by reacting the compound obtained after step b) with an activated carboxylic acid using peptide coupling techniques or an acyl chloride,   c 5 ) formation of a thioamide in the case of Y being HNC(S) or HNC(S)CH 2 , in particular by reacting the compound obtained after step c4) with the Lawesson&#39;s,   d1) optional saponification of the obtained product, preferably by the use of KOH, or   d2) optional saponification obtained from steps c1) to c5), followed by a coupling reaction with various alkylamines.       
 
         [0056]    Yet the present invention also relates to a compound as defined herein characterized in that it is a drug. 
         [0057]    The present invention also relates to a compound as defined herein used as inhibitor of protein kinases in diseases such as tumorigenesis, human immune disorders, inflammatory diseases, thrombotic diseases, neurodegenerative diseases, bone diseases, macular degeneration, fibrosis, cystogenesis, hyperproliferative diseases, cancers, more particularly liquid tumors such as hematological cancers such as leukemias, chronic or acute myeloproliferative disorders or solid tumors such as squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, gastrointestinal cancers, pancreatic cancer, glial cell tumors such as glioblastoma and neurofibromatosis, cervical cancer, ovarian cancer, liver cancer, bladder cancer, breast cancer, melanoma, colorectal cancer, endometrial carcinoma, salivary gland carcinoma, kidney cancer, renal cancer, prostate cancer, vulval cancer, thyroid cancer, sarcomas and/or astrocytomas. 
         [0058]    Pharmaceutical composition, characterized in that it contains, as active principle, a compound as defined herein and a pharmaceutical acceptable excipient. 
       DEFINITIONS 
       [0059]    In general, the following definitions are used 
         [0060]    The expression “peptide coupling” in the present invention means the reaction which enables to form an amide —NH—C(O)—. However the techniques used in this reaction are common in peptide syntheses, i.e. by activating a carboxylic acid in order to enable an amine to react onto it. Therefore, although no peptide is formed in the present invention, the coupling reactions are derived from peptide synthesis, and directly applicable to the subject matter of the present invention. The coupling reactions may be carried out by employing a condensing reagent such as N,N′-dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (EDC), i.e. water-soluble carbodiimide, O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU), benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), O-(7-azabenzotriazol-1-yl)-1,2,3-tetramethyluronium hexafluorophosphate (HATU), O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HBTU), O-benzotriazol-1-yl-tetramethyltetrafluoroborate (TBTU), N-hydroxy-5-norbomene-2,3-dicarbodiimide, or any other coupling agent in a solvent such as ether, acetone, chloroform, dichloromethane, ethyl acetate, DMF, tetrahydrofuran (THF), acetonitrile, dimethylsulfoxide (DMSO), N-methyl pyrrolidinone (NMP), under ice-cooling or at room temperature, preferably in the presence of an acylation catalyst such as dimethylaminopyridine (DMAP), pyridine, N-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), N-hydroxysuccinimide and the like. 
         [0000]    The term “C(O)” is equivalent to “C═O”.
 
The term “C(S)” is equivalent to “C═S”.
 
         [0061]    The expression “alkyl group” in the present invention means a linear or branched saturated aliphatic group with 1 to 6 carbon atoms, if it is not specified. Examples of alkyl groups covered by the scope of the present invention are methyl, ethyl, propyl, butyl, tert-butyl, isopropyl groups, etc. 
         [0062]    The expression “cycloalkyl group” in the present invention means a cyclic alkyl group with 3 to 10 carbon atoms. Examples of alkyl groups covered by the scope of the present invention are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclohexyl, etc. 
         [0063]    The expression “aryl group” in the present invention means a cyclic (mono- or polycyclic) aromatic group comprising between 2 and 10 carbon atoms. Examples of aryl groups covered by the scope of the present invention are phenyl, naphthyl, etc. 
         [0064]    The expression “heteroaryl group” in the present invention means a cyclic (mono- or polycyclic) aromatic group comprising between 2 and 10 carbon atoms and between 1 and 3 heteroatoms, such as nitrogen, oxygen or sulphur. Examples of heteroaryl groups covered by the scope of the present invention are pyridine, thiophene, thiazole, imidazole, pyrazole, pyrrole, quinoline, indol, pyridazine, quinoxaline, dihydrobenzofuran, benzodioxol, benzotriazol, preferably chosen from a group consisting of dihydrobenzofuran, indol, benzodioxol, benzotriazol, pyridine. Optionally the heteroaryl group, and in particular one of the preferred heteroaryl groups, is substituted with a C 1 -C 6  alkyl group, a C 1 -C 6  trifluoroalkyl group, a halogen atom and/or a hydroxyl. 
         [0065]    The expression “non aromatic monosubstituted cyclic group” in the present invention means non aromatic monosubstituted heterocyclic groups. 
         [0066]    The expression “heterocyclic group” in the present invention means a cyclic group comprising between 2 and 10 carbon atoms and between 1 and 3 heteroatoms, such as nitrogen, oxygen and sulphur. The heterocycles can be saturated, i.e. aliphatic, non-saturated, or even aromatic. 
         [0067]    Examples of heterocyclic groups covered by the scope of the present invention are piperazinyl, morpholyl, tetrahydrofuranyl, pyridyl, thiazyl, imidazyl, pyrazyl, quinoxaline, dihydrobenzofuranyl, pyrryl, pyridazinyl, benzimidazyl, pyrimidinyl, 1H-pyrrolo[2,3-b]pyridyl, etc. 
         [0068]    The expression “aliphatic heterocycle” means in the present invention aliphatic cyclic group which comprise one or several heteroatoms, such as morpholine, piperidine, piperazine, pyrrolidine. 
         [0069]    The expression “halogen atom” in the present invention means: fluorine, chlorine, bromine or iodine atoms. 
         [0070]    The expression “alkoxy group” in the present invention means an alkyl group bound to an oxygen. Examples of alkoxy groups covered by the scope of the present invention are methoxy, ethoxy groups etc. 
         [0071]    The expression “aryloxy group” in the present invention means an aryl group bound to an oxygen atom. Examples of aryloxy groups covered by the scope of the present invention are phenyloxy, etc. 
         [0072]    The expression “sulphonamide group” in the present invention means: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0073]    The expression “N-methyl sulphonamide group” in the present invention means: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0074]    The expression “methanesulphonamide group” in the present invention means: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0075]    The expression “aralkyl group” in the present invention means an alkyl group substituted with an aryl group: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0076]    The expression “C 1 -C 6  alkyl amine group” or “C 1 -C 6  alkyl amine group” in the present invention means a C 1 -C 6  alkyl group substituted with an amine group: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0077]    A “secondary C 1 -C 6  alkyl amine group” means an amine substituted with two C 1 -C 6  alkyls (identical or different). 
         [0078]    The expression “hydroxyl group” in the present invention means: OH 
         [0079]    The expression “alkoxyalkyl group” in the present invention means an alkyl group, preferably a substituted with an alkoxy group: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0080]    The expression “sulphanyl group” in the present invention means: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0081]    The expression “ureido” in the present invention is used as a general term for a urea or thiourea. 
         [0082]    The expression “substituted phenyl” in the present invention means a phenyl mono- or poly-substituted with:
       a halogen atom,   a nitro group —(NO 2 ),   a cyano group (CN),   a methylthiazyl group,       
 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             an alkoxy group, 
             an aryloxy group, 
             an alkyl group, 
             a sulphonamide group, 
             an N-methyl sulphonamide group, 
             a methanesulphonamide group, 
             a heteroaryl group, 
             a hydroxyl group, 
             a tertiary amine group, 
             a group —CONHalkyl, 
             a group —NHCOalkyl. 
           
         
       
     
         [0098]    The term “pyridyl” means a radical derived from pyridine 
         [0000]    
       
                 
         
             
             
         
       
     
         [0099]    The term “thiophenyl” in the present invention means a radical derived from thiophene: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0100]    The term “thiazyl” in the present invention means a radical derived from thiazole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0101]    The term “imidazyl” in the present invention means a radical derived from imidazole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0102]    The term “pyrazyl” in the present invention means a radical derived from pyrazole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0103]    The term “quinoxaline” in the present invention means: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0104]    The term “dihydrobenzofuranyl” in the present invention means radical derived from dihydrobenzo furan: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0105]    The term “pyrryl” in the present invention means radical derived from pyrrole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0106]    The term “indyl” in the present invention means a radical derived from indole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0107]    The term “pyridazinyl” in the present invention means radical derived from pyridazine: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0108]    The term “N-morpholyl” in the present invention means radical derived from morpholine: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0109]    The term “benzimidazyl” in the present invention means radical derived from benzimidazole: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0110]    The term “pyrimidinyl” in the present invention means radical derived from pyrimidine: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0111]    The expression “1H-pyrrolo[2,3-b]pyridyl” in the present invention means a radical derived from 1H-pyrrolo[2,3-b]pyridine: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0112]    The expression “pharmaceutical composition” in the present invention means any composition comprising an effective dose of a compound of the invention and at least one pharmaceutically acceptable excipient. Said excipients are selected, depending on the pharmaceutical form and the desired method of administration, from the usual excipients known by a person skilled in the art. 
         [0113]    The expression “pharmaceutically acceptable addition salts” in the present invention means all the pharmaceutically acceptable salts of the compounds according to the invention are included within the scope of the invention, in particular the salts of weak acids and of weak bases, for example the hydrochloride salt, hydrobromide salt, trifluoacetate salt etc. 
         [0114]    The expression “mixtures of enantiomers” in the present invention means any mixture of enantiomers. The mixtures can be racemic, i.e. 50/50% of each enantiomer in weight (w/w), or non-racemic, i.e. enriched in one or the other of the enantiomer so that the ratios w/w are between 50/50% and 75/25%, between 75/25% and 90/10% or above 95% of one enantiomer in comparison with the other. 
         [0115]    The expression “mixtures of diastereoisomers” in the present invention means any mixture of diastereoisomers in any proportions. 
         [0116]    The expression “treatment” is intended to be directed towards all types of animals, preferably mammals, more preferably humans. In the case of a treatment of an animal which is not human kind, it will be referred to a veterinary treatment. 
       DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Products 
       [0117]    The present invention preferably relates to compounds of the following formula (I): 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             characterized in that,
           R1 is C 1 -C 6  alkyl group, hydroxyl group, or NR 4 R 5 ,   R 4  and R 5  are independently a hydrogen atom, and/or C 1 -C 6  alkyl group,   X is CH 2 , C(S) or C(O),   R2 is a hydrogen atom, a C 1 -C 6  alkyl group or a halogen atom,   Y is chosen from a group consisting of HNC(O), HNC(S), HNSO 2 , HNC(O)CH 2 , HNC(S)CH 2 , HNC(O)NH, HNC(S)NH, CH 2 NHC(O), C(O)NH and C(O)NHCH 2 , CH 2 NHC(S), preferably HNC(O),   R3 is chosen from a group consisting of:
               an aryl, preferably a phenyl group mono or polysubstituted with:
                   a hydroxyl group,   a halogen atom,   a C 1 -C 6  alkyl-amine group, preferably a secondary C 1 -C 6  alkyl-amine,   a C 1 -C 6  alkoxy group,   a C 1 -C 6  trifluoroalkoxy group, preferably a trifluoromethoxy,   a C 1 -C 6  alkyl group, preferably a methyl or isopropyl,   a C 1 -C 6  trifluoroalkyl group, preferably a trifluoromethyl, and/or    a heteroaryl group such as thiazol, or imidazol optionally monosubstituted by a methyl,   
                   a heteroaryl group preferably chosen from a group consisting of dihydrobenzofuran, indol, benzodioxol, benzotriazol, pyridine optionally substituted with a C 1 -C 6  alkyl group, a C 1 -C 6  trifluoroalkyl group, a halogen atom and/or a hydroxyl,   a non-aromatic monosubstituted cyclic group, preferably a cyclic C 3 -C 10  alkyl, monosubstituted with a hydroxyl, a halogen, a C 1 -C 6  alkyl-amine, a C 1 -C 6  alkoxy, a C 1 -C 6  trifluoroalkoxy a C 1 -C 6  alkyl, a C 1 -C 6  trifluoroalkyl and   a fragment chosen from a group consisting of:   
               
         
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
         [0000]    and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. 
         [0136]    Advantageously, the compound (I) of the present invention is characterized in that,
       R1 is a hydroxyl group, an alkyl group, preferably methyl, or —NR4R5 wherein R4 and R5 are independently chosen from a hydrogen atom, or an alkyl group, preferably in C 1 -C 6 ,   X is CH 2  or C═O,   R2 is a hydrogen atom, a methyl group or a halogene atom, such as fluorine or chlorine,   —Y is chosen form the group consisting in HNC(O), HNC(S), HNSO 2 , HNC(O)CH 2 , HNC(O)NH, HNC(S)NH, C(O)NH, C(O)NHCH 2 , CH 2 NHC(O) and CH 2 NHC(S),   R3 is chosen from a group consisting of:
           a phenyl group mono or polysubstituted with:
               a hydroxyl group,   a halogen atom,   a C 1 -C 6  alkyl-amine, preferably a secondary C 1 -C 6  alkyl-amine,   a C 1 -C 6  alkoxy,   a C 1 -C 6  trifluoroalkoxy, preferably a trifluoromethoxy,   a C 1 -C 6  alkyl, preferably a methyl, isopropyl,   a C 1 -C 6  trifluoroalkyl, preferably a trifluoromethyl,   a heteroaryl group, preferably chosen from a group consisting of thiazol, imidazol optionally monosubstitued by a CF 3  or a methyl,   
               a heteroaryl group chosen from a group consisting of dihydrobenzofuran, indol, benzodioxol, benzotriazol, pyridine, optionally substituted with a C 1 -C 6  alkyl, a C 1 -C 6  trifluoroalkyl, a halogen and/or a hydroxyl,   non aromatic monosubstituted cyclic group, preferably a cyclic C 3 -C 10  alkyl, monosubstituted with a hydroxyl, a halogen, a C 1 -C 6  alkyl-amine, a C 1 -C 6  alkoxy, a C 1 -C 6  trifluoroalkoxy a C 1 -C 6  alkyl, a C 1 -C 6  trifluoroalkyl and   a fragment is chosen from a group consisting of:   
               
 
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
         [0000]    and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. 
         [0154]    Advantageously, the compound (I) of the present invention is characterized in that,
       X is CH 2 ,   R2 is a C 1 -C 6  alkyl, preferably a methyl group, or a halogen atom preferably a fluorine or chloride atom.       
 
         [0157]    More advantageously, the compound (I) of the present invention is characterized in that,
       R1 is C 1 -C 6  alkyl, preferably a methyl, or —NHMe,   R2 is a methyl, a fluorine or a chlorine atom, preferably a methyl or a chlorine atom   Y is HNC(O), HNC(O)CH 2 , HNC(O)NH, HNC(S)NH, C(O)NH, C(O)NHCH 2 , or CH 2 NHC(O), preferably HNC(O),   R3 is chosen from a group consisting of:
           a phenyl group mono substituted with a C 1 -C 6  trifluoroalkyl group, a C 1 -C 6  trifluoroalkoxy group, a C 1 -C 6  alkyl group, a halogen, or a thiazol group preferably monosubstitued by a CF 3  or a methyl group,   a phenyl group polysubstituted with a C 1 -C 6  trifluoroalkyl, a C 1 -C 6  alkyl-amine, and/or a hydroxyl group,   a pyridine group, optionally substituted with a C 1 -C 6  alkyl or a C 1 -C 6  trifluoroalkyl, preferably methyl and/or a trifluoromethyl,   a non-aromatic cyclic group chosen between a cyclic C 3 -C 10  alkyl, substituted with a C 1 -C 6  alkyl and/or a C 1 -C 6  trifluoroalkyl,   a fragment chosen from a group consisting of:   
               
 
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
         [0167]    Even more advantageously, the compound (I) is characterized in that,
       R1 is a methyl group or —NHMe,   R2 is a methyl group,   Y is HNC*(O), wherein C* is linked to R3 and   R3 is chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0172]    According to a preferred embodiment of the invention, the compound is of formula (II): 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             wherein R1, X, R2, Y and R3 are as defined as above, preferably R3 is chosen from a group consisting of: 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0174]    According to a preferred embodiment of the invention, the compound of formula (II): 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    characterized in that,
       R1 is a methyl group or —NHMe,   X is a CH 2 ,   R2 is methyl group,   Y is HNC*(O), wherein C* is linked to R3 and   R3 is chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    preferably R3 is chosen from a group consisting of: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0180]    In another embodiment of the present invention, the compound (II) of the present invention is characterized in that:
       R1 is a hydroxyl group, a methyl group or —NHMe,   X is CH 2 ,   R2 is a methyl group,   Y is HNC*(O), wherein C* is linked to R3 and   R3 is chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0186]    In a preferred embodiment of the present invention, the compound (II) of the present invention is characterized in that:
       R1 is a hydroxyl group, a methyl group or —NHMe,   X is CH 2 ,   R2 is a methyl group,   Y is HNC*(O), wherein C* is linked to R3 and   R3 is chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0192]    In a preferred embodiment of the present invention, the compound (II) of the present invention is characterized in that:
       R1 is a methyl group or —NHMe,   X is CH 2 ,   R2 is a methyl group,   Y is HNC*(O), wherein C* is linked to R3 and   R3 is chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0198]    In another embodiment of the present invention, all the specific embodiments detailed above can also be characterized in that R1 is a hydroxyl group, the corresponding salt thereof, and/or X is C═O instead of CH 2 . 
         [0199]    In a preferred embodiment of the present invention, all the specific embodiments detailed above can also be characterized in that R1 is C═O instead of CH 2 . 
         [0200]    In a preferred embodiment of the present invention, all the specific embodiments detailed above can also be characterized in that R1 is a hydroxyl group. 
         [0201]    In a preferred embodiment of the present invention, all the specific embodiments detailed above can also be characterized in that R1 is the corresponding salt of the a hydroxyl group, preferably the sodium salt, the potassium salt, lithium salt, magnesium salt or calcium salt. 
         [0202]    In another embodiment of the present invention, the compound (I) of the present invention is characterized in that,
       R1 is C 1 -C 6  alkyl, preferably a methyl, or NR 4 R 5 ,   X is CH 2  or C(O),   R2 is an hydrogen, an alkyl preferably a methyl group, or a halogen atom preferably       
 
         [0206]    a fluorine,
       Y is HNC*(O), wherein C* is linked to R3 or HNC(O)NH, and   R3 is chosen from a group consisting of:   a phenyl group mono substituted with a C 1 -C 6  trifluoroalkyl group, a C 1 -C 6  alkyl group,   a phenyl group polysubstituted with a C 1 -C 6  trifluoroalkyl and a C 1 -C 6  alkyl-amine,   a pyridine group, optionally substituted with a C 1 -C 6  trifluoroalkyl, preferably a trifluoromethyl,   a fragment chosen from a group consisting of:       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0213]    All the compounds of formula (I) or (II) disclosed here can be the pharmaceutically acceptable addition salts, enantiomers, diastereoisomers thereof, as well as mixtures thereof. 
         [0214]    All the compounds according to the invention can be in solvated form and in non-solvated form. 
       Products Synthesis Methods 
       [0215]    The invention also relates to preparation methods of the compounds starting from e.g. 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester and 1-(5-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanone. 
         [0216]    The synthesis of the key intermediate methyl amide compound is represented in Scheme 1. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0217]    The method comprises at least the stages of:
       a) saponification of 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester to afford it&#39;s carboxylic acid derivative, preferably by the use of KOH in MeOH/H 2 O,   b) coupling reaction comprising at least one activating agent such as 2-(7-aza-1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) in the presence of a base such as diisopropylethylamine (DIEA), a carbodiimide such as dicyclocarbodiimide (DCC).       
 
         [0220]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain these types of compounds. 
         [0221]    The synthesis of the key intermediate amine compound is represented in Scheme 2. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R 1  is alkyl, or —NR4R5 as previously defined, and R2 is as previously defined. 
         [0222]    The method comprises at least the stages of:
       c) reduction: for example a catalytic hydrogenation of the resulting nitro compounds, in the presence of palladium on charcoal under hydrogen atmosphere (Seela, F., Gumbiowski, R. Heterocycles, 1989, 29 (4), 795-805),   d) coupling reaction: for example comprising at least one activating agent such as 2-(7-aza-1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) in the presence of a base such as diisopropylethylamine (DIEA), a carbodiimide such as dicyclocarbodiimide (DCC),   e) reductive amination: for example 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester is reacted with various aromatic aldehydes in the presence of boron hydride to give corresponding benzylic amines (Wang, Dong Mei et al Journal of Combinatorial Chemistry, 2009, 11(4), 556-575).       
 
         [0226]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain these types of compounds. 
         [0227]    In another embodiment, the method is represented by Scheme 3. 
         [0228]    Concerning the method to synthesize the ureido compounds disclosed here-above, a method amongst other is represented in Scheme 3: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R1, R2, R3 and X are as defined above, and Y is O or S. 
         [0229]    The preferred method to synthesize the urea compounds thus comprises at least a step of:
       f) reaction of the key intermediate amine compound with various isocyanates or thioisocyanates.       
 
         [0231]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain these types of ureido compounds. 
         [0232]    In another embodiment, the method is represented by Scheme 4 
         [0233]    Concerning the method to synthesize the sulfonamide compounds, a method amongst other is represented in Scheme 4: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R1, R2, R3 and X are as defined above. 
         [0234]    This method to synthesize the sulfonamide compounds comprises at least a step of:
       g) reaction of the key intermediate amine compound with various sulfonyl chlorides.       
 
         [0236]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain these types of sulfonamide compounds. 
         [0237]    In yet another embodiment, the method is represented in Scheme 5. 
         [0238]    Concerning the method to synthesize the amide compounds, two methods amongst other is represented in Scheme 5: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R1, R2, R3 and X are as defined above. 
         [0239]    The methods of Scheme 5 comprise at least a step of:
       h) reaction of the key intermediate amine compound with various acyl chlorides or carboxylic acids (Mouaddib, A., Joseph, B. et al., Synthesis, 2000, (4), 549-556).       
 
         [0241]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain these types of amide compounds. 
         [0242]    Another embodiment concerns the method to synthesize the non-commercially available carboxylic acids obtained according to the following Scheme 6, Scheme 7, Scheme 8 and/or Scheme 9. 
       4-aminomethyl-3-trifluoromethyl-benzoic acids or 4-aminomethyl-3-fluoro-benzoic acids 
       [0243]    A method which was used in the present invention to synthesize 3-substituted 4-aminomethyl-benzoic acids is represented in Scheme 6: 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             where NR 6 R 7  in Scheme 6 can represent: 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0245]    The preferred method to synthesize 4-aminomethyl-benzoic acids comprises at least one of the following steps:
       i) esterification of 3-substituted 4-methyl-benzoic acid derivatives, preferably in methanol, advantageously in an acid medium to give the methylic ester,       
 
         [0247]    j) radical bromination of the methyl group, preferably by N-bromosuccinimide (NBS), advantageously in presence of azobisisobutyronitrile(AIBN) as radical initiator (Sun, Yewei et al,  Bioorganic  &amp;  Medicinal Chemistry , 2008, 16(19), 8868-8874),
       k) brome substitution by various primary and secondary amines,   l) saponification of the ester, preferably methylic ester.       
 
         [0250]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain 3-substituted 4-aminomethyl-benzoic acids however several or even all steps i), j), k) and l) are preferably comprised in the method. 
       3-amino-5-trifluoromethyl-benzoic acids 
       [0251]    A method to synthesize 3-amino-5-trifluoromethyl-benzoic acids is represented in Scheme 7: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    where NR 6 R 7  in Scheme 7 can represent: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0252]    The preferred method to synthesize 3-amino-5-trifluoromethyl-benzoic acids comprises at least one of the following steps:
       m) fluorine substitution by various primary and secondary amines,   n) hydrolysis of the nitrile function to the corresponding carboxylic acid.       
 
         [0255]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain 3-amino-5-trifluoromethyl-benzoic acids, however both steps m) and n) are preferably comprised in the method. 
       3-methyl-5- (4-methyl-piperazin-1-ylmethyl)-benzoic acid 
       [0256]    The method which can be followed to synthesize 3-methyl-5-(4-methyl-piperazin-1-ylmethyl)-benzoic acid used in the present invention is represented in Scheme 8. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0257]    The method comprises at least one of the steps:
       o) radical bromination of the methyl group, preferably by N-bromosuccinimide (NBS) in presence of Azobisisobutyronitrile (AIBN) as radical initiator (Sun, Yewei et al, Bioorganic &amp; Medicinal Chemistry, 2008, 16(19), 8868-8874),   p) brome substitution, preferably by N-methylpiperazine,   q) hydrolysis of the nitrile function to the corresponding carboxylic acid, e.g. with KOH in dioxane.       
 
         [0261]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain 3-methyl-5-(4-methyl-piperazin-1-ylmethyl)-benzoic acid, however several or even all steps o), p) and q) are preferably comprised in the method. 
       3-dimethylamino-5-trifluoromethyl-benzoic acid 
       [0262]    The method which can be followed to synthesize 3-dimethylamino-5-trifluoromethyl-benzoic acid used in the present invention is represented in Scheme 9: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0263]    The method comprises at least one of the steps:
       r) total methylation of the acid and amine functions, preferably by means of methyl iodide,   s) saponification of the resulting ester to give the corresponding carboxylic acid.       
 
         [0266]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain 3-dimethylamino-5-methyl-benzoic acid, however several or even all steps r) and s) are preferably comprised in the method. 
       4-aminomethyl-benzoic acids 
       [0267]    A method which was used in the present invention to synthesize 4-aminomethyl-benzoic acids is represented in Scheme 10. 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             wherein NR 6 R 7  can represent: 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0269]    Advantageously, the method comprises at least one of the following steps:
       t) brome substitution by various primary and secondary amines,   u) saponification of the methylic ester.       
 
         [0272]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain 4-aminomethyl-benzoic acid, however several or even both steps t) and u) are preferably comprised in the method. 
         [0273]    Another embodiment concerns the method to synthesize the thioamides obtained according to the following Scheme 11: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R 1  is alkyl or —NR 4 R 5  as previously defined and R2 and R3 are as previously defined. 
         [0274]    Preferably, the method comprises at least one of the following steps:
       v) treatment of compound A with Lawesson&#39;s reagent (LR) to form it&#39;s thioamide derivative compound B.       
 
         [0276]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain compound B, however steps v) is preferably comprised in the method. 
         [0277]    Another embodiment concerns the method to synthesize thioamides from amides according to the following Scheme 12: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R2 and R3 are as previously defined. 
         [0278]    Preferably, the method comprises at least one of the following steps:
       w) treatment of starting amido-amine derivative with Lawesson&#39;s reagent (LR) to form it&#39;s thioamide derivative,   x) coupling reaction with various carboxylic reagents.       
 
         [0281]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain thioamido-amide final derivative, however steps w) and x) are preferably comprised in the method. 
         [0282]    Another embodiment concerns the method to synthesize acid derivatives (compound D) obtained according as the following: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R2, R3, X are as defined above. 
         [0283]    The method comprises at least the stages of:
       y) saponification of the methyl ester compound C to afford the carboxylic acid derivative, i.e. compound D.       
 
         [0285]    Another embodiment concerns the method to synthesize compound E obtained according as the following: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R2, R3, R4, R5 and X are as defined above. 
         [0286]    Advantageously, the method comprises at least the following step:
       z) coupling reaction comprising at least one activating agent such as 2-(7-aza-1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) or 1-Hydroxybenzotriazole (HOBT) in the presence of a base such as diisopropylethylamine (DIEA), with a carbodiimide such as dicyclocarbodiimide (DCC) or N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide, (EDCI), preferably HOBT, EDCI and DIEA.       
 
         [0288]    The skilled person in the art will naturally apply all other well-known synthesis techniques to obtain compound E, however step z) is preferably comprised in the method. 
         [0289]    Another embodiment concerns the method to synthesize compound F obtained according as the following: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein R 1  is alkyl or —NR 4 R 5  as previously defined and R 1  is as previously defined. 
         [0290]    Preferably, the method comprises at least one of the following steps:
       aa) peptide coupling reaction with the 3-cyano-benzoic acid and an amine derivative,   bb) reduction of the resulting nitrile into the corresponding aldehyde,   cc) reductive amination of the key aldehyde compound with the 5-amino-1H-pyrrolo[2,3-b]pyridine-2-substituted derivative.       
 
         [0294]    Another embodiment concerns the method to synthesize compound G obtained according as the following: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    Wherein R 3  is as previously defined and Y is O or S. 
         [0295]    Preferably, the method comprises at least one of the following steps:
       dd) peptide coupling reaction with the 3-aminomethyl-benzoic acid methyl ester and a carboxylic acid,   ee) reaction of the key intermediate amide compound with Lawesson&#39;s reagent,   ff) saponification of the resulting ester to give the corresponding carboxylic acid,   gg) peptide coupling reaction with the key carboxylic acid compound and the 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester.       
 
       Uses 
       [0300]    The present invention also relates to the use of the compounds according to the invention as inhibitors of protein kinases. Depending of the type of Cancer, one or several kinase proteins will be aimed. 
         [0301]    In one embodiment, the compounds according to the invention are used as inhibitor of protein kinase BRAF. 
         [0302]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EGFR (ErbB1). 
         [0303]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EGFR (ErbB1) T790M L858R. 
         [0304]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FGFR2. 
         [0305]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase KDR (VEGFR2). 
         [0306]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase PDGFRA (PDGFR alpha). 
         [0307]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase SRC. 
         [0308]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL. 
         [0309]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL T315I. 
         [0310]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FGFR1. 
         [0311]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase VEGFR1. 
         [0312]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase PDGFRB (PDGFR beta). 
         [0313]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL E255K. 
         [0314]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL G250E. 
         [0315]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL Y253F. 
         [0316]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ABL2. 
         [0317]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase BLK. 
         [0318]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase BMX. 
         [0319]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase BRAF V600E. 
         [0320]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase BTK. 
         [0321]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase CSK. 
         [0322]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EPHA1. 
         [0323]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EPHA2. 
         [0324]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EPHA4. 
         [0325]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EPHB2. 
         [0326]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase EPHB4. 
         [0327]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase HER2. 
         [0328]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ERBB4. 
         [0329]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FES. 
         [0330]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FGR. 
         [0331]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FLT3. 
         [0332]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FMS. 
         [0333]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FRK. 
         [0334]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase FYN. 
         [0335]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase HCK. 
         [0336]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase LCK. 
         [0337]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase LYN. 
         [0338]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase MAPK14. 
         [0339]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase ERK2. 
         [0340]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase PKC theta. 
         [0341]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase RET. 
         [0342]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase VEGFR3. 
         [0343]    In another embodiment, the compounds according to the invention are used as inhibitors of protein kinase YES. 
         [0344]    Preferably, the compounds according to the invention are used as inhibitor of any one or several of the protein kinases chosen in the group consisting of BRAF, EGFR (ErbB1), EGFR (ErbB1) T790M L858R, FGFR2, KDR (VEGFR2), PDGFRA (PDGFR alpha), SRC, ABL, ABL T315I, FGFR1, VEGFR1, PDGFRB (PDGFR beta). 
         [0345]    More preferably, the compounds according to the invention are used as inhibitor of any one or several of the protein kinases chosen in the group consisting of BRAF, EGFR (ErbB1), EGFR (ErbB1) T790M L858R, FGFR2, KDR (VEGFR2), PDGFRA (PDGFR alpha), SRC. 
         [0346]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of A549 cancer cell line. 
         [0347]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of HepG2 cancer cell line. 
         [0348]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of HuCCT1 cancer cell line. 
         [0349]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of HuH6 Clone 5 cancer cell line. 
         [0350]    In another embodiment, the compounds according to the invention are used as inhibitors the proliferation of HuH7 cancer cell line. 
         [0351]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of PC-3 cancer cell line. 
         [0352]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of Caki-2 cancer cell line. 
         [0353]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of MDA-MB-231 cancer cell line. 
         [0354]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of HT29 cancer cell line. 
         [0355]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BxPC-3 cancer cell line. 
         [0356]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of H1975 cancer cell line. 
         [0357]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 WT. 
         [0358]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 T315I. 
         [0359]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 G250A. 
         [0360]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 G250E. 
         [0361]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 G250A+E279N. 
         [0362]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation of BaF3 E255K+M351T. 
         [0363]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation and migration of HeLa cancer cell line. 
         [0364]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation and migration of HUVEC primary cells. 
         [0365]    In another embodiment, the compounds according to the invention are used as inhibitors of the proliferation and migration of HRMEC primary cells. 
         [0366]    Preferably, the compounds according to the invention are able to inhibit the proliferation of at least one of cancer cell lines chosen in the group consisting of A549, HepG2, HuCCT1, HuH6 Clone 5, HuH7, HT29, BxPC3, H1975, PC3, Caki-2, MDA-MB-231, Hela and/or the proliferation of at least one of primary cells among HUVEC and HRMEC. 
         [0367]    The compounds, and of course pharmaceutical compositions comprising such compounds, of the invention can be used in the treatment of pathologies associated with deregulation of protein kinases:
       in the case of immune disorders, inflammatory diseases, thrombotic diseases, neurodegenerative diseases, bone diseases, macular degeneration, fibrosis, cystogenesis, hyperproliferative diseases,   in the case of all cancers more particularly liquid tumors such as hematological cancers such as leukemias, chronic or acute myeloproliferative disorders or solid tumors such as squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, gastrointestinal cancers, pancreatic cancer, glial cell tumors such as glioblastoma and neurofibromatosis, cervical cancer, ovarian cancer, liver cancer, bladder cancer, breast cancer, melanoma, colorectal cancer, endometrial carcinoma, salivary gland carcinoma, renal cancer, prostate cancer, vulval cancer, thyroid cancer, sarcomas and/or astrocytomas,   in the case of chronic or acute myeloproliferative disorders such as certain leukaemias,   in the case of hepatic, lung, prostate, kidney, breast, pancreatic and colorectal gastrointestinal cancers.       
 
         [0372]    Advantageously, the compounds of the invention, and of course pharmaceutical compositions comprising such compounds, can be used in the treatment of pathologies associated with deregulation of protein kinases in the case of diseases, wherein the diseases is selected from the group consisting of liver cancer, pancreatic cancer, lung cancer, breast cancer, prostate cancer, leukemias, renal cancer, endometrial cancer, colorectal cancer, chemoresistant cancers and macular degeneration. 
         [0373]    According to another aspect, the invention relates to a medicinal product comprising a compound according to the invention as active principle. Thus, the compounds according to the invention can be used as medicinal products in the treatment of pathologies associated with deregulation of protein kinases:
       in the case of immune disorders, inflammatory diseases, thrombotic diseases, neurodegenerative diseases, bone diseases, macular degeneration, fibrosis, cystogenesis, hyperproliferative diseases,   in the case of all cancers more particularly liquid tumors such as hematological cancers such as leukemias, chronic or acute myeloproliferative disorders or solid tumors such as squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, gastrointestinal cancers, pancreatic cancer, glial cell tumors such as glioblastoma and neurofibromatosis, cervical cancer, ovarian cancer, liver cancer, bladder cancer, breast cancer, melanoma, colorectal cancer, endometrial carcinoma, salivary gland carcinoma, renal cancer, prostate cancer, vulval cancer, thyroid cancer, sarcomas and/or astrocytomas,   in the case of chronic or acute myeloproliferative disorders such as certain leukaemias,   in the case of hepatic, lung, prostate, kidney, breast, pancreatic and colorectal gastrointestinal cancers.       
 
         [0378]    The compositions according to the invention can be used in the treatment of pathologies associated with deregulation of protein kinases:
       in the case of immune disorders, inflammatory diseases, thrombotic diseases, neurodegenerative diseases, bone diseases, macular degeneration, fibrosis, cystogenesis, hyperproliferative diseases,   in the case of all cancers more particularly liquid tumors such as hematological cancers such as leukemias, chronic or acute myeloproliferative disorders or solid tumors such as squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, gastrointestinal cancers, pancreatic cancer, glial cell tumors such as glioblastoma and neurofibromatosis, cervical cancer, ovarian cancer, liver cancer, bladder cancer, breast cancer, melanoma, colorectal cancer, endometrial carcinoma, salivary gland carcinoma, renal cancer, prostate cancer, vulval cancer, thyroid cancer, sarcomas and/or astrocytomas,   in the case of chronic or acute myeloproliferative disorders such as certain leukaemias,   in the case of hepatic, lung, prostate, kidney, breast, pancreatic and colorectal gastrointestinal cancers.       
 
         [0383]    Moreover, in an advantageous way, the compounds according to the invention can be used for inhibiting cellular proliferation and/or angiogenesis involved in human or animal diseases. 
         [0384]    In the same way, the compositions according to the invention can be used for inhibiting cellular proliferation and/or angiogenesis involved in human or animal diseases. 
         [0385]    Another aspect of the present invention concerns an in vitro method (in vitro diagnostic device or an imaging tool) for providing information that is essential for the safe and effective use of the compounds according to present invention. As an example, the method will allow predicting whether a patient in need thereof, such as presenting cancer, is likely to respond to at least one of the compounds according to present invention, which method comprises determining the expression level, the gene modifications (amplification, mutation), the activation state or the appearance of a mutated form of the protein of at least one protein kinase in a sample of said patient, wherein said protein kinase is selected from the following list of kinases BRAF, EGFR, FGFR2, KDR, PDGFRA, SRC, ABL, FGFR1, VEGFR1, PDGFRB (PDGFR beta), ABL2, BLK, BMX, BTK, CSK, EPHA1, EPHA2, EPHA4, EPHB2, EPHB4, HER2, ERBB4, FES, FGR, FLT3, FMS, FRK, FYN, HCK, LCK, LYN, MAPK14, ERK2, PKC theta, RET, VEGFR3 and YES, preferably BRAF, EGFR (ErbB1), EGFR (ErbB1) T790M L858R, FGFR2, KDR (VEGFR2), PDGFRA (PDGFR alpha), SRC, ABL, ABL T315I, FGFR1, VEGFR1, PDGFRB (PDGFR beta). 
         [0386]    The expression levels, gene modifications (amplification, mutation), activation state or appearance of a mutated form of the protein kinase is classically determined by the usually known methods (see for example the in vitro and imaging tools of medical devices approved by the FDA: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/ucm 301431.htm) such as real-time PCR, imunohistochemistry, ELISA, fluorescence in situ hybridization (FISH), chromogenic in situ hybridization (CISH). 
         [0387]    Another aspect of the present invention concerns an in vitro method for predicting the at least one compound according to the invention to be administered to a patient in need thereof, such as presenting a cancer, characterized in that it comprises the following steps:
       a) putting into contact said compound(s) with a sample of human tissue or cells,   b) determination of the activity of the compound(s) on the sample via for example IC50 and/or via a compared activity of the protein kinases present, which can for example be chosen from the following list of kinases BRAF, EGFR, EGFR T790M L858R, FGFR2, KDR, PDGFRA, SRC, ABL, ABL T315I, FGFR1, VEGFR1, PDGFRB, ABL E255K, ABL G250E, ABL Y253F, ABL2, BLK, BMX, BRAF V600E, BTK, CSK, EPHA1, EPHA2, EPHA4, EPHB2, EPHB4, HER2, ERBB4, FES, FGR, FLT3, FMS, FRK, FYN, HCK, LCK, LYN, MAPK14, ERK2, PKC theta, RET, VEGFR3 and YES; preferably BRAF, EGFR (ErbB1), EGFR (ErbB1) T790M L858R, FGFR2, KDR (VEGFR2), PDGFRA (PDGFR alpha), SRC, ABL, ABL T315I, FGFR1, VEGFR1, PDGFRB (PDGFR beta).   c) optionally conducting the same test as step a) with healthy cells such as hematological cells or stem cells or hepatic cells of said patient to determine the toxicity of the compound according to the present invention to healthy cells (i.e. not presenting any pathological aspects/properties);       
 
         [0391]    d) selecting the compound according to the present invention presenting the best activity, and/or eventually lowest toxicity, to be administered to the patient in need thereof. 
         [0392]    The methods to determine the activity of the protein kinases are classically known (as reported in Rosen et al., J Biol Chem., 15; 261(29), 13754-9. 1986; Ma et al., Expert Opin Drug Discov., 3(6), 607-621, 2008). 
     
    
     
       FIGURES 
         [0393]      FIG. 1  is a graph representing anti-proliferative activity of some compounds on A549 cells. 
           [0394]      FIG. 2  is a graph representing anti-proliferative activity of some compounds on HepG2 cells. 
           [0395]      FIG. 3  is a graph representing anti-proliferative activity of some compounds on HuCCT1 cells. 
           [0396]      FIG. 4  is a graph representing anti-proliferative activity of some compounds on HuH6 Clone 5 cells. 
           [0397]      FIG. 5  is a graph representing anti-proliferative activity of some compounds on HuH7 cells. 
           [0398]      FIG. 6  is a graph representing anti-proliferative activity of some compounds on HT29 cells. 
           [0399]      FIG. 7  is a graph representing anti-proliferative activity of some compounds on BxPC3 
           [0400]    cells. 
           [0401]      FIG. 8  is a graph representing anti-proliferative activity of some compounds on H1975 cells. 
           [0402]      FIG. 9  is a graph representing anti-proliferative activity of some compounds on HUVEC cells. 
           [0403]      FIG. 10  is a schematic representation of the interactions (hydrophobic contacts, hydrogen bounds and aromatic staking) between compound OR0720 and the amino acids of the kinase domain active site of B-Raf according to the its crystal structure (PDB id=1UWH). 
           [0404]      FIG. 11  is a schematic representation of the interactions (hydrophobic contacts, hydrogen bounds and aromatic staking) between compound OR0720 and the amino acids of the kinase domain active site of VEGFR2 according to the its crystal structure (PDB id=4ASD). 
           [0405]      FIG. 12  is a schematic representation of the interactions (hydrophobic contacts, hydrogen bounds and aromatic staking) between compound OR0720 and the amino acids of the kinase domain active site of EGFR according to a homology model of this kinase. 
           [0406]      FIG. 13  is a schematic representation of the interactions (hydrophobic contacts, hydrogen bounds and aromatic staking) between compound OR0720 and the amino acids of the kinase domain active site of FGFR2 according to a homology model of this kinase. 
       
    
    
     EXAMPLES 
       [0407]    The invention will be better understood on reading the following examples 
         [0408]    The compounds of the invention were obtained from 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester and 1-(5-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanone (commercially available from the company OriBase Pharma) in multi-stage synthesis, if necessary employing parallel synthesis apparatus (“Synthesis 1”, Heidolph). The various synthesis protocols are detailed below together with the physicochemical characteristics of the compounds of the 7-azaindole type obtained. 
         [0409]    The syntheses and analyses were carried out in the following conditions:
         1 H and  13 C nuclear magnetic resonance:       
 
         [0411]    Equipment: Bruker Avance 400 (400 MHz); Bruker Avance 300 (300 MHz); Bruker DPX 200 (200 MHz) 
         [0412]    Conditions of use: Room temperature (RT), chemical shifts expressed in parts per million (ppm), coupling constants (J) expressed in Hertz, internal reference trimethylsilane (TMS), multiplicity of the signals indicated by lower-case letters (singlet s, broad singlet bs, doublet d, triplet t, quadruplet q, multiple m), dimethylsulphoxide d 6 , methanol d 4 , chloroform d, as deuterated solvents. 
         [0413]    High-Performance Liquid Chromatography (HPLC): 
         [0414]    Equipment: Agilent Technology 1260 Infinity 
         [0415]    Conditions of use: Zorbax SB-C18, 2.1×50 mm, 1.8 μm; temperature: 30° C., Water/Acetonitrile/Formic acid elution gradient (90%/10%/0.1% to 0%/100%/0.1%)
       Mass spectrometry (MS):       
 
         [0417]    Equipment: Quadripole Agilent Technologies 6120 
         [0418]    Conditions of use: ElectroSpray (ESI) in positive and/or negative mode. 
         [0419]    Weighings: 
         [0420]    Equipment: Denver Instrument TP214 (precision 0.1 mg) 
         [0421]    Conditions of use: Weighings carried out to the nearest milligram. 
         [0422]    Parallel Synthesis: 
         [0423]    Equipment: Heidolph Synthesis 1 (16 reactors) 
         [0424]    Conditions of use: 16 reactions in parallel, room temperature or 4 heating zones, multiple evaporations. 
         [0425]    REACTIONS UNDER PRESSURE: 
         [0426]    Equipment: Parr 300 mL autoclave. 
         [0427]    Conditions of use: Hydrogenation under 10 to 35 bar of hydrogen. 
         [0000]    
       
                 
         
             
             
         
       
     
       Syntheses 
     Example AA 
     Synthesis of the starting building block 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methylamide 
       [0428]    Scheme 17 represents a general method of synthesis of building block 5-Nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methylamide. 
       Step 1: General protocol for the preparation of 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
       [0429]    5-Nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester (6 g, 27.1 mmoles) was dissolved in methanol/water mixture (1/1). Potassium hydroxide (3 eq) was added and the mixture was heated at reflux overnight. After cooling down, the mixture was acidified until pH=3 by hydrochloric acid 3N. The precipitate was filtered off, washed with water, then diethyl ether, and dried under vacuum. A brownish solid, 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid, is obtained (5.47 g). Yield=98%. ESI-MS: m/z 208 ([M+H] + ). HPLC purity: 100% 
       Step 2: General protocol for the preparation of 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methylamide 
       [0430]    5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (1.3 g, 6.5 mmoles), HATU (1.2 eq) and DIEA (5 eq) were dissolved in dry DMF under argon. After stirring at RT for 15 minutes, methylamine hydrochloride (3 eq) was added and the mixture was allowed to stir at RT overnight. The mixture was concentrated and washed by a saturated solution of sodium carbonate. The precipitate was filtered off, washed with water and diethyl ether to obtain a brownish solid (1.1 g, 5 mmoles). Yield=77%. ESI-MS: m/z 221 ([M+H] + ). HPLC purity: 98%. 
       Example A 
     Synthesis of Example A 
       [0431]    Scheme 18 represents a general method of synthesis of example A 
         [0000]    
       
                 
         
             
             
         
       
     
       Step 1: General protocol for the preparation of 5-amino-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0432]    5-Nitro-1H-pyrrolo[2,3-b]pyridine-2-substituted derivative was dissolved in methanol, introduced in a reactor with 10% Pd/C and stirred for 16 hours under 35 bar of hydrogen. Reaction mixture was then filtered on celite and concentrated to afford the desired compound. 
       1-(5-Amino-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanone 
       [0433]    Yield=95%. ESI-MS: m/z 176 ([M+H] + ). HPLC purity: 96% 
       5-Amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0434]    Yield=86%. ESI-MS: m/z 192 ([M+H] + ). HPLC purity: 97%. 
       5-Amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methylamide 
       [0435]    Yield=87%. ESI-MS: m/z 191 ([M+H] + ). HPLC purity: 96% 
       Step 2: General protocol for the preparation 5-(nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0436]    5-Amino-1H-pyrrolo[2,3-b]pyridine-2-substituted derivative and nitrobenzaldehyde derivative (1 eq) were stirred in AcOH 10% in MeOH for 2 h. Then NaBH 3 CN (2 eq) was slowly added and mixture is stirred under argon for 48 h. Solvents were evaporated and a saturated solution of NaHCO 3  was added until neutrality. Solid formed was filtrated and washed with PET/EtOAc 5/5. 
       1-[5-(3-Nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0437]    Yield=90%. ESI-MS: m/z 311 ([M+H] + ). HPLC purity: 88% 
       1-[5-(2-Fluoro-5-nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0438]    ESI-MS: m/z 329 ([M+H] + ) 
       1-[5-(4-Fluoro-3-nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0439]    Yield=85%. ESI-MS: m/z 329 ([M+H] + ). HPLC purity: &gt;99% 
       1-[5-(2-Methyl-5-nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0440]    Yield=89%. ESI-MS: m/z 325 ([M+H] + ). HPLC purity: 84% 
       5-(2-Methyl-5-nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0441]    Yield=82%. ESI-MS: m/z 341 ([M+H] + ). HPLC purity: 80% 
       5-(2-Methyl-5-nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl amide 
       [0442]    Yield=99%. ESI-MS: m/z 340 ([M+H] + ). HPLC purity: 97% 
       Step 3: General protocol for the preparation 5-(amino-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0443]    5-(nitro-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivative, methanol (300 mL), 7.2 mL of HCl 12N and palladium 10% on charcoal (10% w/w) were put in an autoclave filled with 30 bar of dihydrogen and stirred for 48 h. Mixture was filtered on celite and washed with methanol. Solvent were evaporated, then NaHCO 3(aq)  was added. The solid obtained was filtrated, washed with water to obtain a brownish solid. 
       1-[5-(3-Amino-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0444]    Yield=87%. ESI-MS: m/z 281 ([M+H] + ). HPLC purity: 97% 
       1-[5-(5-Amino-2-fluoro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0445]    Yield=77%. ESI-MS: m/z 299 ([M+H] + ). HPLC purity: 95% 
       1-[5-(3-Amino-4-fluoro-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0446]    Yield=75%. ESI-MS: m/z 299 ([M+H] + ). HPLC purity: 95% 
       1-[5-(5-Amino-2-methyl-benzylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0447]    Yield=70%. ESI-MS: m/z 295 ([M+H] + ). HPLC purity: 94% 
       5-(5-Amino-2-methyl-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0448]    Yield=96%.  1 H NMR (300 MHz, DMSO-d6) δ 12.03 (s, 1H), 8.08 (d, J=2.6 Hz, 1H), 6.95 (d, J=2.7 Hz, 1H), 6.90 (s, 1H), 6.83 (d, J=8.0 Hz, 1H), 6.57 (d, J=2.3 Hz, 1H), 6.36 (dd, J=2.3 Hz, 1H), 5.94 (s, 1H), 4.77 (s, 2H), 4.07 (d, J=5.3 Hz, 2H), 3.83 (s, 4H). ESI-MS: m/z 311 ([M+H] + ). HPLC purity: 95%. 
       5-(5-Amino-2-methyl-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl amide 
       [0449]    Yield=83%. ESI-MS: m/z 310.2 ([M+H] + ). HPLC purity: 99.5% 
       Step 4: General protocol for the preparation 5-(5-benzoylamino-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
     Option 1: Synthesis of 5-(5-benzoylamino-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives by reaction of acyl chlorides 
       [0450]    55 μL of triethylamine (3 eq) and 1.5 eq of acyl chloride are added to a solution of 5-(5-amino-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivative (40 mg, 0.13 mmol) in anhydrous DMF. The reaction mixture is stirred overnight at RT. DMF is evaporated; the solid is taken off into ethyl acetate. The organic layer is washed with saturated NaHCO 3  solution, dried over Na 2 SO 4  and evaporated under reduce pressure to give a yellow solid. 
         [0451]    Table 1 shows the compound synthesized according to the synthesis Scheme 18 described above, with option 1 (i.e. reaction of acyl chlorides). 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Compound obtained by example A with acyl chloride 
               
             
          
           
               
                   
                   
                 Synthesized inhibitors 
               
               
                 Example No. 
                 Used reagents 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR1063 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-fluoro-phenyl}-2- methoxy-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 14% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO-d6) δ 11.90 (s, 
               
               
                   
                   
                 1H), 10.18 (s, 1H), 8.15 (d, J = 2.7, 1H), 7.77- 
               
               
                   
                   
                 7.67 (dd, J = 2.7, 6.9, 1H), 7.72 (m, 1H), 
               
               
                   
                   
                 7.61 (d, J = 7.6, 1H), 7.57-7.48 (m, 1H), 
               
               
                   
                   
                 7.30-7.16 (m, 2H), 7.14 (s, 1H), 7.12-7.03 
               
               
                   
                   
                 (m, 2H), 6.27 (t, J = 5.7, 1H), 4.39 (d, J = 
               
               
                   
                   
                 5.7, 2H), 3.89 (s, 3H), 2.54 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 433 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Option 2: Synthesis of 5-(5-benzoylamino-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives by reaction of carboxylic acids 
       [0452]    All the carboxylic acids involved in this synthesis are not commercially available. First is described the synthesis of these needed carboxylic acids: 
       Synthesis of 4-aminomethyl-benzoic acids 
       [0453]    Scheme 19 represents the general method to synthesize the 4-aminomethyl-benzoic acids 
         [0000]    
       
                 
         
             
             
         
       
     
       General Procedure for Nucleophilic Substitution on Bromomethyl 
       [0454]    4-(Bromomethyl)-benzoic acid alkyl ester (200 mg) in acetonitrile (5 mL) with K 2 CO 3  (1.5 eq) and amine derivative (1.05 eq) were stirred and heated to reflux under argon overnight. Acetonitrile was evaporated, water (30 mL) was added and the product was extracted with AcOEt. The organic layer was washed with water, dried, filtered and concentrated. Further purification was performed by silica gel chromatography to obtain the expected product. 
       4-((4-Methylpiperazin-1-yl)methyl)-benzoic acid methyl ester 
       [0455]    Yield=60% (15.7 g). ESI-MS: [M+H] + =263.1 Da 
       4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-benzoic acid ethyl ester 
       [0456]    Yield=64%. ESI-MS: [M+H] + =277 Da. 
       General Procedure for Saponification  
       [0457]    Ester derivative was dissolved in THF (0.8 mol/L) and a water solution of LiOH (3 eq) was added. Mixture was heated to reflux for 4 h. THF was evaporated and impurities were extracted with EtOAc at pH=12. Aqueous layer was saturated with NaCl(s) and acidified until pH=3 with HCl 6 N. Product was extracted with Butan-1-ol. Butan-1-ol was evaporated and the solid obtained was washed with EtOAc to remove salts and impurities. A white solid was obtained. 
       4-((4-Methylpiperazin-1-yl)methyl)-benzoic acid 
       [0458]    Yield quantitative. ESI-MS: [M+H] + =235.1 Da 
       4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-benzoic acid 
       [0459]    Yield quantitative. ESI-MS: [M+H] += 249 Da. 
       Synthesis of 4-aminomethyl-3-trifluoromethyl-benzoic acids 
       [0460]    Scheme 20 represents the general method to synthesize the 4-aminomethyl-3-trifluoromethyl-benzoic acids: 
         [0000]    
       
                 
         
             
             
         
       
     
       Synthesis of 4-(bromomethyl)-3-(trifluoromethyl) benzoic acid 
       [0461]    4-Methyl-3-(trifluoromethyl)benzoic acid methyl ester (3.73 g, 18.3 mmol) in CCl 4  (40 mL) with NBS (3.9 g, 22 mmol) and benzoylperoxide with 25% of water (0.55 g, 1.7 mmol) were stirred and heated to reflux for 6 h. Solvent was evaporated, a water solution of K 2 CO 3  was added and product is extracted with EtOAc to obtain a pale yellow solid (7.64 g, 25.7 mmol). 
         [0462]    Yield=140% (crude). 
       General Procedure for Nucleophilic Substitution on Bromomethyl 
       [0463]    4-(Bromomethyl)-3-(trifluoromethyl)benzoic acid (200 mg) in acetonitrile (5 mL) with K 2 CO 3  (1.5 eq) and amine derivative (1.05 eq) were stirred and heated to reflux under argon overnight. Acetonitrile was evaporated, water (30 mL) was added and impurities were extracted with EtOAc at pH=12. Aqueous layer was saturated with NaCl(s) and acidified until pH=3 with HCl 6 N. Product was extracted with Butan-1-ol. Butan-1-ol was evaporated and the solid obtained was washed with EtOAc to remove salts and impurities. A white solid was obtained. 
       4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid 
       [0464]    Yield=89%.  1 H NMR (300 MHz, DMSO-d6) δ 10.44 (m, 1H), 8.19 (s, 1H), 8.18 (m, 1H), 7.93 (m, 1H), 3.79 (s, 2H), 2.75 (s, 3H). ESI-MS: [M+H] + =303 Da. 
       4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-trifluoromethyl-benzoic acid 
       [0465]    Yield: 83%. HPLC: 92% ESI-MS: [M+H] + =317 Da 
       Synthesis of 4-aminomethyl-3-Fluoro-benzoic acids 
       [0466]    Scheme 21 represents the general method to synthesize the 4-aminomethyl-3-substituted-benzoic acids. 
         [0000]    
       
                 
         
             
             
         
       
     
       Procedure for Esterification  
       [0467]    4-Methyl-3-fluoro-benzoic acid (24 mmol) in methanol (50 mL) with H 2 SO 4  (0.260 mL, 4.8 mmol) are stirred and heated to reflux for one night. Methanol is evaporated and product is extracted at pH=7 with EtOAc. 
       4-Methyl-3-fluoro-benzoic acid methyl ester 
       [0468]    Yield=83% (4.0 g), HPLC: 98%, ESI-MS: [M+H]+=169 Da 
       Procedure for Bromination 
       [0469]    4-methyl-3-fluoro-benzoic acid methyl ester (18.3 mmol) in CCl 4  (40 mL) with NBS (3.9 g, 22 mmol) and benzoylperoxide with 25% of water (0.55 g, 1.7 mmole) are stirred and heated to reflux for 6 h. Solvent is evaporated, a water solution of K 2 CO 3  is added and product is extracted with EtOAc to obtain a pale yellow solid. 
       4-(bromomethyl)-3-fluoro benzoic acid methyl ester 
       [0470]    Yield=quant (5.9 g), ESI-MS: [M+H] + =247 Da 
       General Procedure for Nucleophilic Substitution on Bromomethyl 
       [0471]    4-(Bromomethyl)-3-fluoro-benzoic acid methyl ester (200 mg) in acetonitrile (5 mL) with K 2 CO 3  (1.5 eq) and amine derivative (1.05 eq) were stirred and heated to reflux under argon overnight. Acetonitrile was evaporated, water (30 mL) was added and the product was extracted with AcOEt. The organic layer was washed with water, dried, filtered and concentrated. Further purification was performed by silica gel chromatography to obtain the expected product. 
       3-Fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester 
       [0472]    Yield=49% (1.48 g). HPLC: 88%, ESI-MS: [M+H] + =267 Da 
       4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-fluoro-benzoic acid methyl ester 
       [0473]    Yield: 60% (2 g). HPLC: 85% ESI-MS: [M+H] + =281 Da. 
       General Procedure for Saponification 
       [0474]    Ester derivative was dissolved in THF (0.8 mol/L) and a water solution of LiOH (3 eq) was added. Mixture was heated to reflux for 4 h. THF was evaporated and impurities were extracted with EtOAc at pH=12. Aqueous layer was saturated with NaCl(s) and acidified until pH=3 with HCl 6 N. Product was extracted with Butan-1-ol. Butan-1-ol was evaporated and the solid obtained was washed with EtOAc to remove salts and impurities. A white solid was obtained. 
       3-Fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid 
       [0475]    Yield=65% (0.91 g). HPLC: &gt;99%, ESI-MS: [M+H] + =253 Da 
       4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-fluoro-benzoic acid 
       [0476]    Yield: 36% (687 mg). ESI-MS: [M+H] + =267 Da. 
       Synthesis of 5-trifluoromethyl-benzoic acid 3 substituted derivatives 
       [0477]    Scheme 22 represents the general method to synthesize the 5-trifluoromethyl-benzoic acid 3 substituted derivatives. 
         [0000]    
       
                 
         
             
             
         
       
     
       General Procedure for Nucleophilic Substitution 
       [0478]    A solution of 3-fluoro-5-trifluoromethyl-benzonitrile (1 eq) and the corresponding amine (3 eq) in DMA was stirred at 145° C. during 3 h. NaCl (aq)  was added. The product was taken off into ethyl acetate. The organic layer was washed two times with water then dried over Na 2 SO 4  and evaporated under reduced pressure to give a white solid. 
       3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzonitrile 
       [0479]    Yield: 74%. HPLC: 100% ESI-MS: [M+H] + =252 Da 
       3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-benzonitrile 
       [0480]    Yield: quantitative. HPLC: 94% ESI-MS: [M+H] + =270 Da. 
       General Procedure for Hydrolysis of Nitrile 
       [0481]    At a solution of nitrile derivative in dioxane (0.13M) was added NaOH (10 eq, 1 g/L) in H 2 O. The mixture was heat at reflux overnight. After evaporation of the dioxane, the aqueous layer was washed with AcOEt, then acidified with HCl 2N and extract with AcOEt. The organic layer was dried over Na 2 SO 4  filtered and concentrated. 
       3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzoic acid 
       [0482]    Yield: 99%. HPLC: 100%. ESI-MS: [M+H] + =271 Da 
       3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-benzoic acid 
       [0483]    Yield: 60%. HPLC: 100%. ESI-MS: [M+H] + =289 Da. 
       General protocol for the preparation 5-(5,2-substituted-benzylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0484]    Acid derivative is dissolved in anhydrous DMF (0.06 mol/L) with DIEA (5 eq) and HATU (2 eq). After 15 min, 5-{2-substituted-5-amino-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-substituted intermediate is slowly added and mixture is stirred for 12 h at RT. DMF is evaporated and NaHCO 3(aq)  is added. Product is extracted with EtOAc, dried, filtered and evaporated to obtain a dark mixture. After purification by washing with MeOH or EtOAc or by silica column, expected product is obtained as a slightly yellow or orange powder. 
         [0485]    Table 2 shows the compounds synthesized according to the synthesis Scheme 22 described above. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Compounds obtained by example A with carboxylic acids 
               
             
          
           
               
                 Example  
                   
                 Synthesized inhibitors 
               
               
                 No. 
                 Used reagents 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0929 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 Cyclopropanecarboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 70% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.83 (s, 1H), 10.03 
               
               
                   
                   
                 (s, 1H), 8.10 (d, J = 2.6, 1H), 7.52 (dd, J = 1.7, 8.2, 
               
               
                   
                   
                 1H), 7.43 (d, J = 1.7, 1H), 7.10 (d, J = 8.2, 1H), 7.06 
               
               
                   
                   
                 (s, 1H), 6.94 (d, J = 2.6, 1H), 6.08 (t, J = 5.4, 1H), 
               
               
                   
                   
                 4.19 (d, J = 5.4, 2H), 2.47 (s, 3H), 2.28 (s, 3H), 1.71 
               
               
                   
                   
                 (qt, J = 6.5, 1H), 0.72 (d, J = 6.5, 4H) 
               
               
                   
                   
                 HPLC: 99%; MS: 363 (M + 1) 
               
               
                   
               
               
                 OR1058 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 4-Trifluoromethyl-cyclohexanecarboxylic acid {3- [(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)- methyl]-4-fluoro-phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 43% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.86 (s, 1H), 9.81 
               
               
                   
                   
                 (s, 1H), 8.09 (d, J = 1.8, 1H), 7.63-7.54 (m, 2H), 
               
               
                   
                   
                 7.13 (t, J = 9.1, 1H), 7.08 (d, J = 1.8, 1H), 7.01 (dd, J = 
               
               
                   
                   
                 2.4, 6.5, 1H), 4.31 (s, 2H), 2.61-2.53 (m, 1H), 
               
               
                   
                   
                 2.48 (s, 3H), 2.35-2.17 (m, 1H), 1.97-1.80 (m, 
               
               
                   
                   
                 4H), 1.75-1.49 (m, 4H) 
               
               
                   
                   
                 HPLC: 98%; MS: 477 (M + 1) 
               
               
                   
               
               
                 OR0986 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1H-Pyrrole-3-carboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 17% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.82 (s, 1H), 11.21 
               
               
                   
                   
                 (s, 1H), 9.38 (s, 1H), 8.24-8.01 (m, 1H), 7.65 (s, 
               
               
                   
                   
                 1H), 7.61 (d, J = 8.2, 1H), 7.47 (s, 1H), 7.12 (d, J =  
               
               
                   
                   
                 8.2, 1H), 7.07 (s, 1H), 7.01 (s, 1H), 6.77 (s, 1H), 6.60 
               
               
                   
                   
                 (s, 1H), 6.12-5.93 (m, 1H), 4.20 (s, 2H), 2.30 (s, 3H) 
               
               
                   
                   
                 HPLC: 92%; MS: 388 (M + 1) 
               
               
                   
               
               
                 OR0987 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 2H-Pyrazole-3-carboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 43% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 13.33 (s, 1H), 11.81 
               
               
                   
                   
                 (s, 1H), 9.86 (s, 1H), 8.12 (d, J = 2.5, 1H), 7.85 (s, 
               
               
                   
                   
                 1H), 7.78 (s, 1H), 7.63 (d, J = 8.1, 1H), 7.14 (d, J =  
               
               
                   
                   
                 8.1, 1H), 7.06 (d, J = 2.1, 1H), 7.01 (d, J = 2.5, 1H), 
               
               
                   
                   
                 6.72 (s, 1H), 6.01 (s, 1H), 4.21 (d, J = 5.2, 2H), 2.48 
               
               
                   
                   
                 (s, 3H), 2.31 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 401 (M + 1) 
               
               
                   
               
               
                 OR0988 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 Pyrimidine-4-carboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 53% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.82 (s, 1H), 10.68 
               
               
                   
                   
                 (s, 1H), 9.37 (s, 1H), 9.09 (d, J = 5.0, 1H), 8.13 (m, 
               
               
                   
                   
                 1H), 8.08 (d, J = 5.0, 1H), 7.85 (s, 1H), 7.73 (d, J =  
               
               
                   
                   
                 8.2, 1H), 7.21 (d, J = 8.2, 1H), 7.06 (s, 1H), 6.99 (s, 
               
               
                   
                   
                 1H), 6.08 (t, J = 4.0, 1H), 4.25 (d, J = 4.0, 2H), 2.47 
               
               
                   
                   
                 (s, 3H), 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 401 (M + 1) 
               
               
                   
               
               
                 OR0980 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1H-Indole-5-carboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 50% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.82 (s, 1H), 11.35 
               
               
                   
                   
                 (s, 1H), 10.01 (s, 1H), 8.27-8.17 (m, 1H), 8.17-8.06 
               
               
                   
                   
                 (m, 1H), 7.80-7.73 (m, 1H), 7.73-7.61 (m, 2H), 7.50- 
               
               
                   
                   
                 7.38 (m, 2H), 7.16 (d, J = 8.1, 1H), 7.11-7.04 (m, 1H), 
               
               
                   
                   
                 7.04-6.96 (m, 1H), 6.60-6.50 (m, 1H), 6.05 (t, J = 4.3, 
               
               
                   
                   
                 1H), 4.23 (d, J = 4.3, 2H), 2.48 (s, 3H), 2.33 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 438 (M + 1) 
               
               
                   
               
               
                 OR0979 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1H-Benzotriazole-5-carboxylic acid {3-[(2-acetyl-1H- pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl- phenyl}-amide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 34% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.84 (s, 1H), 10.33 
               
               
                   
                   
                 (s, 1H), 8.73-8.43 (m, 1H), 8.30-8.06 (m, 1H), 
               
               
                   
                   
                 8.06-7.85 (m, 2H), 7.80-7.72 (m, 1H), 7.69 (d, J =  
               
               
                   
                   
                 8.4 Hz, 1H), 7.20 (d, J = 8.1 Hz, 1H), 7.13-7.05 (m, 
               
               
                   
                   
                 1H), 7.05-6.96 (m, 1H), 6.44-5.77 (m, 1H), 4.25 
               
               
                   
                   
                 (s, 2H), 2.48 (s, 3H), 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 440 (M + 1) 
               
               
                   
               
               
                 OR0950 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-phenyl}-5-trifluoromethyl- nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 38% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.80 (s, 1H), 10.65 
               
               
                   
                   
                 (s, 1H), 9.35 (d, J = 1.6, 1H), 9.17 (d, J = 1.6, 1H), 
               
               
                   
                   
                 8.67 (t, J = 1.6, 1H), 8.09 (d, J = 2.7, 1H), 7.80 (s, 
               
               
                   
                   
                 1H), 7.68 (d, J = 7.8, 1H), 7.35 (t, J = 7.8, 1H), 7.20 
               
               
                   
                   
                 (d, J = 7.8, 1H), 7.05 (s, 1H), 6.98 (d, J = 2.7, 1H), 
               
               
                   
                   
                 6.31 (t, J = 5.9, 1H), 4.33 (d, J = 5.9, 2H), 2.47 (s, 3H) 
               
               
                   
                   
                 HPLC: 97%; MS: 454 (M + 1) 
               
               
                   
               
               
                 OR0721 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-5- trifluoromethyl-nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 9% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.80 (s, 1H), 10.51 
               
               
                   
                   
                 (s, 1H), 9.31 (s, 1H), 9.13 (s, 1H), 8.62 (s, 1H), 8.11 
               
               
                   
                   
                 (d, J = 2.4, 1H), 7.70-7.62 (m, 2H), 7.22 (d, J = 8.9, 
               
               
                   
                   
                 1H), 7.06 (s, 1H), 6.97 (d, J = 2.4, 1H), 6.11 (t, J =  
               
               
                   
                   
                 5.3, 1H), 4.25 (d, J = 5.3, 2H), 2.47 (s, 3H), 2.35 (s, 
               
               
                   
                   
                 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 468 (M + 1) 
               
               
                   
               
               
                 OR0970 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{5-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-fluoro-phenyl}-5- trifluoromethyl-nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 72% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.75 (s, 1H), 10.67 
               
               
                   
                   
                 (s, 1H), 9.32 (d, J = 1.2, 1H), 9.14 (d, J = 1.2, 1H), 
               
               
                   
                   
                 8.62 (t, 1.2, 1H), 8.10 (d, J = 2.6, 1H), 7.84-7.67 (m, 
               
               
                   
                   
                 2H), 7.25 (t, J = 9.3, 1H), 7.07 (s, 1H), 7.00 (d, J =  
               
               
                   
                   
                 2.6, 1H), 6.27 (t, J = 5.7, 1H), 4.36 (d, J = 5.7, 2H), 
               
               
                   
                   
                 2.47 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 472 (M + 1) 
               
               
                   
               
               
                 OR0894 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{5-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-2-fluoro-phenyl}-5- trifluoromethyl-nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 15% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.83 (s, 1H), 10.58 
               
               
                   
                   
                 (s, 1H), 9.35 (d, J = 2.2, 1H), 9.18 (d, J = 2.2, 1H), 
               
               
                   
                   
                 8.67 (t, J = 2.2, 1H), 8.07 (d, J = 2.7, 1H), 7.69 (dd, J =  
               
               
                   
                   
                 2.1, 7.5, 1H), 7.34-7.24 (m, 2H), 7.05 (s, 1H), 
               
               
                   
                   
                 7.00 (d, J = 2.7, 1H), 6.31 (t, J = 6.1, 1H), 4.32 (d, J =  
               
               
                   
                   
                 6.1, 2H), 2.47 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 472 (M + 1) 
               
               
                   
               
               
                 OR0886 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-6- trifluoromethyl-nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 17% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.83 (s, 1H), 10.54 
               
               
                   
                   
                 (s, 1H), 9.18 (s, 1H), 8.50 (d, J = 8.0, 1H), 8.11 (s, 
               
               
                   
                   
                 1H), 8.05 (d, J = 8.0, 1H), 7.67 (d, J = 8.6, 1H), 7.66 
               
               
                   
                   
                 (s, 1H), 7.22 (d, J = 8.6, 1H), 7.06 (d, J = 1.8, 1H), 
               
               
                   
                   
                 6.95 (d, J = 1.8, 1H), 6.15 (t, J = 5.2, 1H), 4.25 (d, J =  
               
               
                   
                   
                 5.2, 2H), 2.47 (s, 3H), 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 468 (M + 1) 
               
               
                   
               
               
                 OR0887 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-2- trifluoromethyl-isonicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 3% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.83 (s, 1H), 10.60 
               
               
                   
                   
                 (s, 1H), 8.93 (d, J = 5.0, 1H), 8.30 (s, 1H), 8.14 (d, J =  
               
               
                   
                   
                 5.0, 1H), 8.11 (d, J = 2.6, 1H), 7.67 (d, J = 8.3, 1H), 
               
               
                   
                   
                 7.66 (s, 1H), 7.22 (d, J = 8.3, 1H), 7.06 (s, 1H), 6.96 
               
               
                   
                   
                 (d, J = 2.6, 1H), 6.15 (t, J = 5.4, 1H), 4.25 (d, J = 5.4, 
               
               
                   
                   
                 2H), 2.47 (s, 3H), 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 468 (M + 1) 
               
               
                   
               
               
                 OR0888 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-5-methyl- nicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 6% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.83 (s, 1H), 10.30 
               
               
                   
                   
                 (s, 1H), 8.85 (s, 1H), 8.57 (s, 1H), 8.12 (s, 1H), 8.06 
               
               
                   
                   
                 (s, 1H), 7.67 (s, 1H), 7.66 (d, J = 7.6, 1H), 7.19 (d, J =  
               
               
                   
                   
                 7.6, 1H), 7.07 (s, 1H), 6.97 (s, 1H), 6.11 (t, J = 5.2, 
               
               
                   
                   
                 1H), 4.24 (d, J = 5.2, 2H), 2.47 (s, 3H), 2.36 (s, 3H), 
               
               
                   
                   
                 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 414 (M + 1) 
               
               
                   
               
               
                 OR0889 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-2-methyl- isonicotinamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 41% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.84 (s, 1H), 10.35 
               
               
                   
                   
                 (s, 1H), 8.58 (d, J = 5.0, 1H), 8.11 (d, J = 2.7, 1H), 
               
               
                   
                   
                 7.68-7.62 (m, 3H), 7.59 (d, J = 5.0, 1H), 7.21 (d, J =  
               
               
                   
                   
                 8.1, 1H), 7.06 (s, 1H), 6.96 (d, J = 2.7, 1H), 6.12 (t, J =  
               
               
                   
                   
                 5.5, 1H), 4.23 (d, J = 5.5, 2H), 2.53 (s, 3H), 2.47 (s, 
               
               
                   
                   
                 3H), 2.33 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 414 (M + 1) 
               
               
                   
               
               
                 OR1080 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4- dimethylamino-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 50% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO) δ 11.81 (s, 1H), 9.76 (s, 
               
               
                   
                   
                 1H), 8.12 (bs, 1H), 7.83 (bs, 1H), 7.81 (bs, 1H), 7.70 
               
               
                   
                   
                 (d, J = 1.6, 1H), 7.63 (dd, J = 2.1, 8.2, 1H), 7.14 (d, J = 
               
               
                   
                   
                 8.2, 1H), 7.07 (d, J = 1.7, 1H), 7.00 (d, J = 2.2, 1H), 
               
               
                   
                   
                 6.73 (bs, 1H), 6.70 (bs, 1H), 6.03 (t, J = 5.4, 1H), 4.21 
               
               
                   
                   
                 (d, J = 5.1, 2H), 2.97 (s, 6H), 2.48 (s, 3H), 2.32 (s, 
               
               
                   
                   
                 3H). 
               
               
                   
                   
                 HPLC: 98%; MS: 442 (M + 1) 
               
               
                   
               
               
                 OR1079 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-3- trifluoromethoxy-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 59% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO) δ 11.82 (s, 1H), 10.28 
               
               
                   
                   
                 (s, 1H), 8.12 (bs, 1H), 7.96 (d, J = 7.8, 1H), 7.86 (bs, 
               
               
                   
                   
                 1H), 7.72-7.61 (m, 3H), 7.57 (d, J = 8.4, 1H), 7.20 
               
               
                   
                   
                 (d, J = 8.1, 1H), 7.06 (d, J = 1.5, 1H), 6.99 (d, J = 1.6, 
               
               
                   
                   
                 1H), 6.15-6.03 (m, 1H), 4.31-4.19 (m, 2H), 2.47 
               
               
                   
                   
                 (s, 3H), 2.34 (s, 3H). 
               
               
                   
                   
                 HPLC: 99%; MS: 483 (M + 1) 
               
               
                   
               
               
                 OR0734 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-(4-methyl- piperazin-1-ylmethyl)-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 26% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO) δ 11.82 (s, 1H), 10.10 
               
               
                   
                   
                 (s, 1H), 8.11 (s, 1H), 7.85 (d, J = 7.8, 2H), 7.75-7.60 
               
               
                   
                   
                 (m, 2H), 7.39 (d, J = 7.9, 2H), 7.17 (d, J = 7.8, 1H), 
               
               
                   
                   
                 7.06 (s, 1H), 6.99 (s, 1H), 6.07 (t, J = 5.5, 1H), 4.22 
               
               
                   
                   
                 (s, 2H), 3.50 (s, 2H), 2.47 (s, 3H), 2.42-2.18 (bs, 
               
               
                   
                   
                 11H), 2.14 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 511 (M + 1) 
               
               
                   
               
               
                 OR0753 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)- benzoylamino]-benzylamino}-1H-pyrrolo[2,3- b]pyridine-2-carboxylic acid methylamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 3% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO) δ 11.51 (s, 1H), 10.09 
               
               
                   
                   
                 (s, 1H), 8.26 (d, J = 4.4, 1H), 7.98 (s, 1H), 7.85 (d, J = 
               
               
                   
                   
                 8.1, 2H), 7.70 (s, 1H), 7.64 (d, J = 7.8, 1H), 7.39 (d, 
               
               
                   
                   
                 J = 8.1, 2H), 7.16 (d, J = 7.8, 1H), 6.99 (d, J = 2.0, 
               
               
                   
                   
                 1H), 6.77 (d, J = 2.0, 1H), 5.87 (t, J = 5.2, 1H), 4.21 
               
               
                   
                   
                 (d, J = 5.2, 2H), 3.50 (s, 3H), 2.78 (d, J = 4.4, 3H), 
               
               
                   
                   
                 2.32 (bs, 10H), 2.15 (s, 3H) 
               
               
                   
                   
                 HPLC: 94%; MS: 526 (M + 1) 
               
               
                   
               
               
                 OR0751 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3- trifluoromethyl-benzoylamino]-benzylamino}-1H- pyrrolo[2,3-b]pyridine-2-carboxylic acid methylamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 18% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO) δ 11.48 (s, 1H), 10.31 
               
               
                   
                   
                 (s, 1H), 8.23 (d, J = 4.7, 1H), 8.17 (s, 1H), 8.14 (s, 
               
               
                   
                   
                 1H), 7.95 (s, 1H), 7.85 (d, J = 8.0, 1H), 7.65 (s, 1H), 
               
               
                   
                   
                 7.62 (d, J = 8.0, 1H), 7.16 (s, 1H), 6.96 (s, 1H), 6.75 
               
               
                   
                   
                 (s, 1H), 5.87 (t, J = 5.4, 1H), 4.20 (d, J = 5.4, 2H), 
               
               
                   
                   
                 3.63 (s, 2H), 2.75 (d, J = 4.7, 3H), 2.31 (s, 3H), 2.16 
               
               
                   
                   
                 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 594 (M + 1) 
               
               
                   
               
               
                 OR0890 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-methyl-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 28% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.86 (s, 1H), 10.31 
               
               
                   
                   
                 (s, 1H), 8.19 (s, 1H), 8.12 (s, 1H) 8.10 (d, J = 7.7, 
               
               
                   
                   
                 1H), 7.68 (s, 1H), 7.65 (dd, J = 2.0, 8.2, 1H), 7.58 (d,  
               
               
                   
                   
                 J = 7.7, 1H), 7.19 (d, J = 8.2, 1H), 7.08 (d, J = 2.0, 1H), 
               
               
                   
                   
                 7.01 (s, 1H), 6.12 (s, 1H), 4.24 (s, 2H), 2.47 (s, 6H), 
               
               
                   
                   
                 2.33 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 481 (M + 1) 
               
               
                   
               
               
                 OR0891 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-chloro-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 14% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.85 (s, 1H), 10.42 
               
               
                   
                   
                 (s, 1H), 8.33 (d, J = 1.5, 1H), 8.21 (dd, J = 1.5, 8.5, 
               
               
                   
                   
                 1H), 8.12 (s, 1H), 7.87 (d, J = 8.5, 1H), 7.67-7.63 
               
               
                   
                   
                 (m, 2H), 7.21 (d, J = 7.9, 1H), 7.07 (d, J = 1.7, 1H), 
               
               
                   
                   
                 7.02 (s, 1H), 6.13 (s, 1H), 4.25 (s, 2H), 2.47 (s, 3H), 
               
               
                   
                   
                 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 502 (M + 1) 
               
               
                   
               
               
                 OR1056 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-2-fluoro-phenyl}-4-hydroxy-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 20% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.82 (s, 1H), 10.07 
               
               
                   
                   
                 (s, 1H), 8.17 (s, 1H), 8.08 (s, 1H), 8.06 (d, J = 7.5, 
               
               
                   
                   
                 1H), 7.59 (d, J = 7.5, 1H), 7.34-7.19 (m, 2H), 7.15- 
               
               
                   
                   
                 6.95 (t, 3H), 6.28 (t, J = 5.7, 1H), 4.31 (d, J = 5.7, 
               
               
                   
                   
                 2H), 2.48 (s, 3H), 
               
               
                   
                   
                 HPLC: 98%; MS: 487 (M + 1) 
               
               
                   
               
               
                 OR0893 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 16% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.83 (s, 1H), 10.38 
               
               
                   
                   
                 (s, 1H), 8.24 (s, 1H), 8.21 (d, J = 8.0, 1H), 8.12 (d, J =  
               
               
                   
                   
                 2.0, 1H), 7.93 (d, J = 7.8, 1H), 7.74 (t, J = 7.8, 1H), 
               
               
                   
                   
                 7.68 (s, 1H) 7.67 (dd, J = 1.6, 7.8, 1H), 7.20 (d, J =  
               
               
                   
                   
                 8.0, 1H), 7.06 (d, J = 1.6, 1H), 6.98 (d, J = 2.0, 1H), 
               
               
                   
                   
                 6.11 (t, J = 5.1, 1H), 4.24 (d, J = 5.1, 2H), 2.47 (s, 
               
               
                   
                   
                 3H), 2.34 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 467 (M + 1) 
               
               
                   
               
               
                 OR0926 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-phenyl}-4-(4-methyl-piperazin-1- ylmethyl)-3-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 26% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.83 (s, 1H), 10.44 
               
               
                   
                   
                 (s, 1H), 8.22 (s, 1H), 8.20 (d, J = 7.8 , 1H), 8.09 (d, J = 
               
               
                   
                   
                 2.4, 1H), 7.91 (d, J = 8.1, 1H), 7.80 (s, 1H), 7.67 
               
               
                   
                   
                 (dd, J = 1.8, 7.8, 1H), 7.33 (t, J = 7.8, 1H), 7.17 (d, J =  
               
               
                   
                   
                 8.1, 1H), 7.05 (d, J = 1.8, 1H), 6.98 (d, J = 2.4, 1H), 
               
               
                   
                   
                 6.29 (t, J = 5.9, 1H), 4.31 (d, J = 5.9, 2H), 3.67 (s, 
               
               
                   
                   
                 2H), 2.47 (s, 3H), 2.44-2.28 (m, 8H), 2.16 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 565 (M + 1) 
               
               
                   
               
               
                 OR0720 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-(4-methyl- piperazin-1-ylmethyl)-3-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 12% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.85 (s, 1H), 10.37 
               
               
                   
                   
                 (s, 1H), 8.19 (d, J = 8.2, 2H), 8.13 (d, J = 2.6, 1H), 
               
               
                   
                   
                 7.88 (d, J = 8.2, 1H), 7.67 (d, J = 7.9, 2H), 7.21 (d, J =  
               
               
                   
                   
                 7.9, 1H), 7.08 (d, J = 2.0, 1H), 6.99 (d, J = 2.6, 1H), 
               
               
                   
                   
                 6.12 (t, J = 5.2, 1H), 4.25 (d, J = 5.2, 2H), 3.66 (s, 
               
               
                   
                   
                 2H), 2.48 (s, 3H), 2.35 (bs, 8H), 2.33 (s, 3H), 2.16 (s,  
               
               
                   
                   
                 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 579 (M + 1) 
               
               
                   
               
               
                 OR0972 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-fluoro-phenyl}-4-(4-methyl- piperazin-1-ylmethyl)-3-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 39% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.75 (s, 1H), 10.49 
               
               
                   
                   
                 (s, 1H), 8.19 (s, 1H), 8.17 (d, J = 7.8, 1H), 8.10 (d, J =  
               
               
                   
                   
                 2.5, 1H), 7.88 (d, J = 7.8, 1H), 7.79 (dd, J = 2.6, 6.6, 
               
               
                   
                   
                 1H), 7.76-7.69 (m, 1H), 7.22 (t, J = 9.3, 1H), 7.07 (s, 
               
               
                   
                   
                 1H), 7.01 (d, J = 2.5, 1H), 6.24 (t, J = 5.5, 1H), 4.35 
               
               
                   
                   
                 (d, J = 5.5, 2H), 3.65 (s, 2H), 2.47 (s, 3H), 2.39 (bs, 
               
               
                   
                   
                 4H), 2.33 (bs, 4H), 2.15 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 583 (M + 1) 
               
               
                   
               
               
                 OR0928 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-2-fluoro-phenyl}-4-(4-methyl- piperazin-1-ylmethyl)-3-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 12% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.82 (s, 1H), 10.35 
               
               
                   
                   
                 (s, 1H), 8.25 (s, 1H), 8.22 (d, J = 8.1, 1H), 8.07 (d, J =  
               
               
                   
                   
                 2.5, 1H), 7.91 (d, J = 8.1, 1H), 7.61 (dd, J = 2.1, 7.5, 
               
               
                   
                   
                 1H), 7.35-7.30 (m, 2H), 7.05 (d, J = 2.1, 1H), 7.01 
               
               
                   
                   
                 (d, J = 2.5, 1H), 6.30 (t, J = 6.1, 1H), 4.32 (d, J = 6.1, 
               
               
                   
                   
                 2H), 3.67 (s, 2H), 2.47 (s, 3H), 2.41 (bs, 4H), 2.36 
               
               
                   
                   
                 (bs, 4H), 2.17 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 583 (M + 1) 
               
               
                   
               
               
                 OR0885 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-3-fluoro-4-(4- methyl-piperazin-1-ylmethyl)-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 4%  1 H NMR (300 MHz, DMSO): δ 11.85 (s, 1H), 10.19 
               
               
                   
                   
                 (s, 1H), 8.14 (d, J = 2.5, 1H), 7.79-7.70 (m, 3H), 
               
               
                   
                   
                 7.67 (dd, J = 2.1, 8.2, 1H), 7.53 (t, J = 7.3, 1H), 7.21 
               
               
                   
                   
                 (d, J = 8.2, 1H), 7.09 (d, J = 2.1, 1H), 7.01 (d, J = 2.5, 
               
               
                   
                   
                 1H), 6.11 (t, J = 5.3, 1H), 4.26 (d, J = 5.3, 2H), 3.57 
               
               
                   
                   
                 (s, 2H), 2.50 (s, 3H), 2.46-2.21 (m, 11H), 2.16 (s, 
               
               
                   
                   
                 3H) 
               
               
                   
                   
                 HPLC: 90%; MS: 530 (M + 1) 
               
               
                   
               
               
                 OR0973 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-(3- dimethylamino-pyrrolidin-1-ylmethyl)-3-fluoro- benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 10% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.82 (s, 1H), 10.17 
               
               
                   
                   
                 (s, 1H), 8.11 (d, J = 2.6, 1H), 7.76-7.60 (m, 4H), 
               
               
                   
                   
                 7.50 (t, J = 8.3, 1H), 7.18 (d, J = 8.3, 1H), 7.06 (s, 
               
               
                   
                   
                 1H), 6.98 (d, J = 2.6, 1H), 6.07 (t, J = 5.3, 1H), 4.23 
               
               
                   
                   
                 (d, J = 5.3, 2H), 3.67 (d, J = 13.3, 1H), 3.60 (d, J =  
               
               
                   
                   
                 13.3, 1H), 2.75-2.56 (m, 3H), 2.48 (s, 3H), 2.46- 
               
               
                   
                   
                 2.40 (m, 1H), 2.33 (s, 3H), 2.31-2.24 (m, 1H), 2.06 
               
               
                   
                   
                 (s, 6H), 1.86-1.82 (m, 1H), 1.65-1.51 (m, 1H) 
               
               
                   
                   
                 HPLC: 97%; MS: 543 (M + 1) 
               
               
                   
               
               
                 OR0718 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-(3- dimethylamino-pyrrolidin-1-ylmethyl)-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 4% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.84 (s, 1H), 10.37 
               
               
                   
                   
                 (s, 1H), 8.21-8.16 (m, 2H), 8.13 (d, J = 2.6, 1H), 
               
               
                   
                   
                 7.86 (d, J = 8.6, 1H), 7.72-7.65 (m, 2H), 7.21 (d, J =  
               
               
                   
                   
                 7.9, 1H), 7.08 (s, 1H), 6.99 (d, J = 2.6, 1H), 6.12 (t, J =  
               
               
                   
                   
                 5.2, 1H), 4.25 (d, J = 5.2, 2H), 3.80 (t, J = 15.0, 
               
               
                   
                   
                 1H), 3.72 (t, J = 15.0, 1H), 2.93-2.75 (m, 1H), 2.69- 
               
               
                   
                   
                 2.52 (m, 3H), 2.48 (s, 3H), 2.44-2.36 (m, 1H), 
               
               
                   
                   
                 2.34 (s, 3H), 2.14 (s, 6H), 1.93-1.82 (m, 1H), 1.72- 
               
               
                   
                   
                 1.59 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 593 (M + 1) 
               
               
                   
               
               
                 OR0949 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-2-fluoro-phenyl}-4-(3- dimethylamino-pyrrolidin-1-ylmethyl)-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 16% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.80 (s, 1H), 10.38 
               
               
                   
                   
                 (s, 1H), 8.25 (s, 1H), 8.22 (d, J = 7.6 , 1H), 8.07 (d, J =  
               
               
                   
                   
                 2.6, 1H), 7.88 (d, J = 7.6, 1H), 7.61 (dd, J = 1.6, 6.0, 
               
               
                   
                   
                 1H), 7.35-7.21 (m, 2H), 7.05 (s, 1H), 7.00 (d, J = 2.6, 
               
               
                   
                   
                 1H), 6.28 (s, 1H), 4.32 (s, 2H), 3.82 (d, J = 15.0, 1H), 
               
               
                   
                   
                 3.73 (d, J = 15.0, 1H), 2.74-2.63 (m, 4H), 2.47 (s, 
               
               
                   
                   
                 3H), 2.42-2.30 (m, 1H), 2.08 (s, 6H), 1.95-1.79 
               
               
                   
                   
                 (m, 1H), 1.72-1.54 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 597 (M + 1) 
               
               
                   
               
               
                 OR0811 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-4-((S)-3- dimethylamino-pyrrolidin-1-ylmethyl)-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 45% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.82 (s, 1H), 10.34 
               
               
                   
                   
                 (s, 1H), 8.22-8.14 (m, 2H), 8.11 (d, J = 2.3, 1H), 
               
               
                   
                   
                 7.85 (d, J = 8.0, 1H), 7.71-7.60 (m, 2H), 7.20 (d, J =  
               
               
                   
                   
                 8.0, 1H), 7.06 (s, 1H), 6.98 (d, J = 2.3, 1H), 6.09 (t, J =  
               
               
                   
                   
                 4.8, 1H), 4.24 (d, J = 4.8, 2H), 3.80 (d, J = 14.8, 
               
               
                   
                   
                 1H), 3.72 (d, J = 14.8, 1H), 2.86-2.70 (m, 1H), 2.69- 
               
               
                   
                   
                 2.54 (m, 3H), 2.47 (s, 3H), 2.42-2.34 (m, 1H), 
               
               
                   
                   
                 2.34 (s, 3H), 2.09 (s, 6H), 1.96-1.77 (m, 1H), 1.75- 
               
               
                   
                   
                 1.55 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 593 (M + 1) 
               
               
                   
               
               
                 OR0971 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-fluoro-phenyl}-4-((S)-3- dimethylamino-pyrrolidin-1-ylmethyl)-3- trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 53% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.82 (s, 1H), 10.45 
               
               
                   
                   
                 (s, 1H), 8.19 (s, 1H), 8.17 (d, J = 8.2, 1H), 8.10 (d, J =  
               
               
                   
                   
                 2.5, 1H), 7.86 (d, J = 8.2, 1H), 7.80 (dd, J = 2.3, 6.4, 
               
               
                   
                   
                 1H), 7.75-7.65 (m, 1H), 7.23 (t, J = 9.3, 1H), 7.07 
               
               
                   
                   
                 (s, 1H), 7.01 (d, J = 2.5, 1H), 6.25 (t, J = 5.2, 1H), 
               
               
                   
                   
                 4.35 (d, J = 5.2, 2H), 3.81 (d, J = 14.7, 1H), 3.72 (d, J =  
               
               
                   
                   
                 14.7, 1H), 2.81-2.55 (m, 4H), 2.47 (s, 3H), 2.41- 
               
               
                   
                   
                 2.30 (m, 1H), 2.07 (s, 6H), 1.94-1.78 (m, 1H), 1.70- 
               
               
                   
                   
                 1.55 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 597 (M + 1) 
               
               
                   
               
               
                 OR0927 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-phenyl}-4-((S)-3-dimethylamino- pyrrolidin-1-ylmethyl)-3-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 22% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.82 (s, 1H), 10.44 
               
               
                   
                   
                 (s, 1H), 8.22 (s, 1H), 8.21 (d, J = 7.8, 1H), 8.09 (d, J =  
               
               
                   
                   
                 2.6, 1H), 7.88 (d, J = 7.9, 1H), 7.81 (s, 1H), 7.67 (d, J = 
               
               
                   
                   
                 7.9, 1H), 7.33 (t, J = 7.8, 1H), 7.17 (d, J = 7.8, 1H), 
               
               
                   
                   
                 7.05 (s, 1H), 6.98 (d, J = 2.6, 1H), 6.28 (t, J = 5.5, 
               
               
                   
                   
                 1H), 4.31 (d, J = 5.5, 2H), 3.82 (d, J = 15.0, 1H), 3.74 
               
               
                   
                   
                 (d, J = 15.0, 1H), 2.76-2.68 (m, 1H), 2.67-2.56 
               
               
                   
                   
                 (m, 3H), 2.47 (s, 3H), 2.40-2.32 (m, 1H), 2.08 (s, 
               
               
                   
                   
                 6H), 1.90-1.82 (m, 1H), 1.66-1.62 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 579 (M + 1) 
               
               
                   
               
               
                 OR0752 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 5-{5-[4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3- trifluoromethyl-benzoylamino]-2-methyl- benzylamino}-1H-pyrrolo[2,3-b]pyridine-2- carboxylic acid methylamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 6% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO) δ 11.51 (s, 1H), 10.33 
               
               
                   
                   
                 (s, 1H), 8.26 (d, J = 4.6, 1H), 8.18 (s, 1H), 8.17 (d, J = 
               
               
                   
                   
                 8.3, 1H), 7.98 (d, J = 2.5, 1H), 7.85 (d, J = 7.9, 
               
               
                   
                   
                 1H), 7.68 (s, 1H), 7.65 (dd, J = 2.0, 7.9, 1H), 7.19 (d, 
               
               
                   
                   
                 J = 8.3, 1H), 6.99 (d, J = 2.5, 1H), 6.77 (d, J = 2.0, 
               
               
                   
                   
                 1H), 5.90 (t, J = 5.5, 1H), 4.23 (d, J = 5.5, 2H), 3.78 
               
               
                   
                   
                 (dd, J = 15.1, 1H), 3.74 (dd, J = 15.1, 1H), 2.78 (d, J =  
               
               
                   
                   
                 4.6, 3H), 2.76-2.69 (m, 1H), 2.68-2.56 (m, 3H), 
               
               
                   
                   
                 2.39-2.34 (m, 1H), 2.33 (s, 3H), 2.08 (d, J = 3.3, 
               
               
                   
                   
                 6H), 1.92-1.82 (m, 1H), 1.68-1.58 (m, 1H) 
               
               
                   
                   
                 HPLC: 97%; MS: 608 (M + 1) 
               
               
                   
               
               
                 OR0813 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 5-{5-[4-((S)-3-Dimethylamino-pyrrolidin-1- ylmethyl)-3-trifluoromethyl-benzoylamino]-2- methyl-benzylamino}-1H-pyrrolo-[2,3-b]pyridine-2- carboxylic acid methylamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 30% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.53 (s, 1H), 10.34 
               
               
                   
                   
                 (s, 1H), 8.27 (q, J = 4.1, 1H), 8.22-8.14 (m, 2H), 
               
               
                   
                   
                 7.98 (s, 1H), 7.85 (d, J = 7.6, 1H), 7.72-7.61 (m, 
               
               
                   
                   
                 2H), 7.19 (d, J = 7.6, 1H), 6.99 (s, 1H), 6.77 (s, 1H), 
               
               
                   
                   
                 5.91 (t, J = 4.5, 1H), 4.23 (d, J = 4.5, 2H), 3.81 (d, J =  
               
               
                   
                   
                 14.7, 1H), 3.72 (d, J = 14.7, 1H), 2.78 (d, J = 4.1, 
               
               
                   
                   
                 3H), 2.73-2.55 (m, 3H), 2.43 2.34 (m, 2H), 2.33 (s, 
               
               
                   
                   
                 3H), 2.07 (s, 6H), 1.94-1.79 (m, 1H), 1.73-1.58 
               
               
                   
                   
                 (m, 1H) 
               
               
                   
                   
                 HPLC: 99%; MS: 608 (M + 1) 
               
               
                   
               
               
                 OR0719 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-3-(4-methyl- imidazol-1-yl)-5-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 7% 
               
               
                   
                   
                   1 H NMR (400 MHz, DMSO): δ 11.77 (s, 1H), 10.46 
               
               
                   
                   
                 (s, 1H), 8.40 (s, 1H), 8.35 (s, 1H), 8.16 (s, 1H), 8.10 
               
               
                   
                   
                 (s, 1H), 8.08 (s, 1H), 7.71-7.61 (m, 3H), 7.19 (d, J =  
               
               
                   
                   
                 8.3, 1H), 7.03 (d, J = 2.0, 1H), 6.96 (d, J = 2.6, 1H), 
               
               
                   
                   
                 6.07 (t, J = 5.3, 1H), 4.23 (d, J = 5.3, 2H), 2.44 (s, 
               
               
                   
                   
                 3H), 2.32 (s, 3H), 2.14 (s, 3H) 
               
               
                   
                   
                 HPLC: 97%; MS: 547 (M + 1) 
               
               
                   
               
               
                 OR1060 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-fluoro-phenyl}-3-(4-methyl- piperazin-1-yl)-5-trifluoromethyl-benzamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 27% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.84 (s, 1H), 10.37 
               
               
                   
                   
                 (s, 1H), 8.09 (s, 1H), 7.84-7.75 (m, 1H), 7.74-7.63 
               
               
                   
                   
                 (m, 2H), 7.60 (s, 1H), 7.39 (s, 1H), 7.24 (t, J = 9.2, 
               
               
                   
                   
                 1H), 7.07 (s, 1H), 7.01 (s, 1H), 6.24 (t, J = 5.2, 1H), 
               
               
                   
                   
                 4.35 (d, J = 5.2, 2H), 3.48-3.38 (m, 4H), 2.91-2.72 
               
               
                   
                   
                 (m, 4H), 2.49 (s, 3H), 2.47 (s, 3H) 
               
               
                   
                   
                 HPLC: 98%; MS: 569 (M + 1) 
               
               
                   
               
               
                 OR0968 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5- ylamino)-methyl]-4-methyl-phenyl}-2-(3- trifluoromethyl-phenyl)-acetamide                            
 
               
               
                   
               
               
                   
                   
                 Yield: 51% 
               
               
                   
                   
                   1 H NMR (300 MHz, DMSO): δ 11.83 (s, 1H), 10.08 
               
               
                   
                   
                 (s, 1H), 8.09 (s, 1H), 7.64 (s, 1H), 7.62-7.47 (m, 
               
               
                   
                   
                 4H), 7.42 (s, 1H), 7.11 (d, J = 8.1 Hz, 1H), 7.05 (s, 
               
               
                   
                   
                 1H), 6.94 (s, 1H), 6.08 (t, J = 4.3 Hz, 1H), 4.20 (d, J =  
               
               
                   
                   
                 4.3 Hz, 2H), 3.70 (s, 2H), 2.47 (s, 3H), 2.29 (s, 3H) 
               
               
                   
                   
                 HPLC: 99%; MS: 481 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example B 
     Synthesis of 5-(5-benzoylamino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0486]    Scheme 23 represents a general method of synthesis of 5-(5-benzoylamino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivates. 
         [0000]    
       
                 
         
             
             
         
       
     
       Step 1: General protocol for the preparation of 5-(2-methyl-5-nitro-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0487]    5-Amino-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives, acid 2-methyl-5-nitrobenzylique (1 eq), HATU (1 eq), DIEA (5 eq) were dissolved in anhydrous DMF and stirred 48 h at RT. DMF was evaporated, NaHCO 3(aq)  was added, a precipitate occurred and was filtered, washed with water and petroleum ether/Et 2 O. 
       1-[5-(2-methyl-5-nitro-benzoylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0488]    Yield=69%. ESI-MS: m/z 339 ([M+H]+). HPLC purity: 100% 
       5-(2-methyl-5-nitro-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0489]    Yield=93%.  1 H NMR (300 MHz, DMSO-d6) δ 8.53 (s, 2H), 8.37 (d, J=2.5, 1H), 8.26 (dd, J=2.5, 8.4, 1H), 7.63 (d, J=8.5, 1H), 7.16 (s, 1H), 3.86 (s, 3H), 3.17 (s, 1H), 2.54 (s, 3H). 
         [0490]    ESI-MS: m/z 355 ([M+H] + ). HPLC purity: 95%. 
       Step 2: General protocol for the preparation of 5-(5-amino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives  
       [0491]    5-(2-Methyl-5-nitro-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives, methanol and palladium 10% on charcoal (10% w/w) were put in an autoclave filled with 30 bar of dihydrogen and stirred for 24 h. Mixture was filtered on celite and washed with methanol. Solvent was evaporated to obtain a solid. 
       1-[5-(5-amino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridin-2-yl]-ethanone 
       [0492]    Yield=99%. ESI-MS: m/z 309 ([M+H]+). HPLC purity: 92% 
       5-(5-amino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0493]    Yield=81%.  1 H NMR (300 MHz, DMSO-d6) δ 10.29 (s, 1H), 8.55 (s, 2H), 7.15 (s, 1H), 6.94 (d, J=8.2, 1H), 6.71 (d, J=2.3, 1H), 6.60 (m, 1H), 5.08 (s, 2H), 3.86 (s, 3H), 2.21 (s, 3H). 
         [0494]    ESI-MS: m/z 325 ([M+H]+). HPLC purity: 95%. 
       Step 3: General protocol for the preparation of 5-(5-benzoylamino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives 
       [0495]    Acid derivative was dissolved in anhydrous DMF (0.06 mol/L) with DIEA (5 eq) and HATU (2 eq). After 15 min, 5-{2-methyl-5-[3-amino]-benzoylamino}-1H-pyrrolo[2,3-b]pyridine-2-substituted derivatives was slowly added and mixture is stirred for 12 h at RT. DMF was evaporated and NaHCO 3(aq)  was added. Product was extracted with EtOAc, dried, filtered and evaporated to obtain a dark mixture. After purification by washing with MeOH or EtOAc or by silica column, expected product was obtained as a slightly yellow or orange powder. 
         [0496]    Table 3 shows the compounds synthesized according to the synthesis Scheme 23 described above. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 Compounds obtained by example B 
               
             
          
           
               
                 Example 
                   
                 Synthesized inhibitors 
               
               
                 No. 
                 Used reagents 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0780 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2- methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)- benzoylamino]-benzamide                            
   Yield: 5%  1 H NMR (300 MHz, DMSO) δ 12.27 (s, 1H), 10.50 (s, 1H), 10.31 (s, 1H), 8.63 (s, 1H), 8.61 (s, 1H), 7.95 (s, 1H), 7.93 (d, J = 8.1, 2H), 7.83 (d, J = 8.4, 1H), 7.45 (d, J = 8.1, 2H), 7.38 (s, 1H), 7.30 (d, J = 8.4, 1H), 3.53 (s, 2H), 2.57 (s, 3H), 2.38 (bs, 11H), 2.17 (s, 3H) HPLC: 93%; MS: 525.3 (M + 1) 
               
               
                   
               
               
                 OR0781 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2- methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3- trifluoromethyl-benzoylamino]-benzamide                            
   Yield: 10%  1 H NMR (300 MHz, DMSO) δ 12.29 (s, 1H), 10.54 (s, 1H), 10.52 (s, 1H), 8.62 (s, 1H), 8.61 (s, 1H), 8.55-8.15 (m, 2H), 7.99-7.88 (m, 2H), 7.84 (d, J = 8.3, 1H), 7.38 (s, 1H), 7.33 (d, J = 8.3, 1H), 3.68 (s, 2H), 2.57 (s, 3H), 2.41 (m, 11H), 2.17 (s, 3H) HPLC: 97%; MS: 593 (M + 1) 
               
               
                   
               
               
                 OR0782 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2- methyl-5-[4-(3-dimethylamino-pyrrolidin-1- ylmethyl)-3-trifluoromethyl-benzoylamino]- benzamide                            
   Yield: 8%  1 H NMR (300 MHz, DMSO) δ 12.28 (s, 1H), 10.54 (s, 1H), 10.52 (s, 1H), 8.67-8.55 (m, 2H), 8.29- 2.21 (m, 2H), 7.94-7.88 (m, 2H), 7.85 (d, J = 8.3, 1H), 7.38 (s, 1H), 7.33 (d, J = 8.3, 1H), 3.84 (d, J = 15.2, 1H), 3.75 (d, J = 15.2, 1H), 2.90-2.76 (m, 1H), 2.74-2.58 (m, 3H), 2.57 (s, 3H), 2.45-2.33 (m, 4H), 2.13 (s, 6H), 1.99-1.80 (m, 1H), 1.78- 1.57 (m, 1H) HPLC: 98%; MS: 607 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example C 
     Synthesis of Ureido Derivatives 
       [0497]    General method to synthesize ureido derivatives is represented by Scheme 24: 
         [0000]    
       
                 
         
             
             
         
       
     
       General Protocol for the Preparation Ureido Derivatives 
       [0498]    To a solution of amino derivative was added the isocyanate or isothiocyanate derivative (1 eq). The mixture was allowed to stir at RT overnight. The solvent was removed and the crude product was purified by reverse phase chromatography. 
         [0499]    Table 4 shows the compounds synthesized according to the synthesis described above in Scheme 24. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Compounds obtained by example C 
               
             
          
           
               
                 Example 
                   
                 Synthesized inhibitors 
               
               
                 No. 
                 Used reagents 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0897 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)- methyl]-4-methyl-phenyl}-3-pyridin-3-yl-urea                            
   Yield: 6%  1 H NMR (300 MHz, DMSO-d6) δ 11.81 (s, 1H), 8.69 (s, 1H), 8.67 (s, 1H), 8.54 (d, J = 2.3, 1H), 8.16 (dd, J = 1.2, 4.6, 1H), 8.11 (d, J = 2.6, 1H), 7.89 (dd, 2.6, 8.3, 1H), 7.41 (dd, J = 2.6, 8.3, 1H), 7.29 (dd, J = 4.6, 8.3, 1H), 7.25 (d, J = 2.2, 1H), 7.11 (d, J = 8.3, 1H), 7.06 (d, J = 2.2, 1H), 6.97 (d, J = 2.6, 1H), 6.11 (bs, 1H), 4.22 (s, 2H), 2.47 (s, 3H), 2.29 (s, 3H) HPLC: 98%; MS: 415 (M + 1) 
               
               
                   
               
               
                 OR0895 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)- methyl]-4-methyl-phenyl}-3-(3-trifluoromethyl-phenyl)- urea                            
   Yield: 16%  1 H NMR (400 MHz, DMSO-d6) δ 11.83 (s, 1H), 8.88 (s, 1H), 8.66 (s, 1H), 8.12 (d, J = 2.3, 1H), 7.97 (s, 1H), 7.54-7.45 (m, 2H), 7.45-7.37 (m, 1H), 7.32-7.21 (m, 2H), 7.12 (d, J = 8.3, 1H), 7.06 (d, J = 2.0, 1H), 6.97 (d,  J = 2.3, 1H), 6.12 (t, J = 5.0, 1H), 4.22 (d, J = 5.0, 2H), 2.47 (s, 3H), 2.29 (s, 3H). HPLC: 98%; MS: 482 (M + 1) 
               
               
                   
               
               
                 OR0951 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methyl-5- [3-(3-trifluoromethyl-phenyl)-ureido]-benzamide                            
   Yield: 11%  1 H NMR (400 MHz, DMSO-d6) δ 12.27 (s, 1H), 10.48 (s, 1H), 9.12 (s, 1H), 8.93 (s, 1H), 8.62 (dd, J = 2.2, 7.4, 2H), 8.03 (s, 1H), 7.65 (d, J = 2.2, 1H), 7.58 (d, J = 8.2, 1H), 7.52 (d, J = 7.4, 1H), 7.47 (dd, J = 2.0, 8.2, 1H), 7.38 (d, J = 2.0, 1H), 7.31 (d, J = 7.4, 1H), 7.24 (d, J = 8.2, 1H), 2.57 (s, 3H), 2.35 (s, 3H). HPLC: 86%; MS: 496 (M + 1) 
               
               
                   
               
               
                 OR1015 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 1-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)- methyl]-4-methyl-phenyl}-3-(3-trifluoromethyl-phenyl)- thiourea                            
   Yield: 21 %  1 H NMR (400 MHz, DMSO-d6) δ (ppm) 11.92 (s, 1H), 9.93 (s, 1H), 9.81 (s, 1H), 8.13 (s, 1H), 7.94 (s, 1H), 7.66 (d, J = 7.9, 1H), 7.49 (t, J = 7.9, 1H), 7.41 (d, J = 7.9, 1H), 7.35 (d, J = 8.7, 1H), 7.34 (s, 1H), 7.19 (d, J = 8.7, 1H), 7.11 (s, 1H), 7.07 (s, 1H), 4.27 (s, 2H), 2.48 (s, 3H), 2.33 (s, 3H) HPLC: 90%; MS: 498 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example D 
     Synthesis of Benzenesulfonamide Derivatives 
       [0500]    General method to synthesize benzenesulfonamide derivatives is represented by Scheme 25: 
         [0000]    
       
                 
         
             
             
         
       
     
       Synthesis of N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-4-methyl-phenyl}-3-trifluoromethyl-benzenesulfonamide  
       [0501]    The amine precursor (100 mg) is dissolved in pyridine and sulfonyl chloride (1.5 eq) was added. The mixture was stirred overnight at RT under argon. The crude was concentrated and washed with NaHCO 3  solution. The organic layer was extracted with EtOAc. After evaporation the crude was purified on reverse phase chromatography. 
         [0502]    Table 5 shows the compounds synthesized according to the synthesis described above in Scheme 25. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 Compound obtained by example D 
               
             
          
           
               
                 Example 
                   
                 Synthesized inhibitors 
               
               
                 No. 
                 Used reagents 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0930 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)- methyl]-4-methyl-phenyl}-3-trifluoromethyl- benzenesulfonamide                            
   Yield: 33%  1 H NMR (400 MHz, DMSO) δ 11.84 (s, 1H), 10.22 (s, 1H), 8.04 (d, J = 2.6, 1H), 7.93 (s, 1H), 7.81 (d, J = 7.9, 1H), 7.73 (d, J = 8.1, 1H), 7.50 (t, J = 7.9, 1H), 7.10- 6.98 (m, 3H), 6.86-6.78 (m, 2H), 6.07 (t, J = 5.5, 1H), 4.13 (d, J = 5.5, 2H), 2.48 (s, 3H), 2.22 (s, 3H) HPLC: 99%; MS: 503 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example E 
     Synthesis of Compounds from Example E 
       [0503]    General method to synthesize compound from example E is represented by Scheme 26. 
         [0000]    
       
                 
         
             
             
         
       
     
       Step 1: General protocol for the preparation of 3-cyano benzamide intermediates 
       [0504]    3-Cyano-benzoic acid (1.2 eq), the amine derivative (1 eq), HOBt (1.2 eq), DIEA (1.2 eq) and EDCI.HCl (1.2 eq) were dissolved in dry DMF (0.15 M), under argon. The mixture was stirred at room temperature overnight. DMF is evaporated and saturated NaHCO 3  solution was added. Product was extracted with EtOAc, dried over Na 2 SO 4 , filtered and evaporated. The crude was purified on reverse phase (H 2 O 1% TFA/MeCN 1% TFA 100/0, 0/100). MeCN was evaporated. The product was suspended in H 2 O and basified with saturated NaHCO 3  solution until pH=8-9. The aqueous layer was extracted three times with AcOEt. The organic layer was evaporated to give the final compound. 
       3-Cyano-N-pyridin-3-yl-benzamide 
       [0505]    Brown powder. Yield: 47% (563 mg). HPLC: &gt;99%. MS: 224 (M+1) 
       3-Cyano-N-(3-trifluoromethyl-benzyl)-benzamide 
       [0506]    White powder. Yield: 76% (333 mg). HPLC: &gt;99%. MS: 305 (M+1). 
       Step 2: General protocol for the preparation of 3-Formyl-3-yl-benzamide derivatives 
       [0507]    Under argon, 3-cyano-benzamide precursor (1 eq) was dissolved in a mixture of pyridine/water/acetic acid (2/1/1; 0.01M). Ni Raney in water (˜0.03 vol) was added and the mixture was stirred at room temperature overnight under hydrogen at atmospheric pressure. Then, the mixture was filtered over celite bed and washed with methanol. Solvents were evaporated. Saturated NaHCO 3  solution was added. Product was extracted with EtOAc, dried over Na 2 SO 4 , filtered and evaporated to give the final compound. 
       3-Formyl-N-pyridin-3-yl-benzamide 
       [0508]    Yellow oil. Yield: 66% (166 mg). HPLC: &gt;99%. MS: 227 (M+1) 
       3-Formyl-N-(3-trifluoromethyl-benzyl)-benzamide 
       [0509]    Yellow oil. Yield: 83% (42 mg). HPLC: 94%. MS: 308 (M+1). 
       Step 3: General protocol for the preparation of 3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-N-pyridin-3-yl-benzamide (OR0917) 
       [0510]    1-(5-Amino-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethanone (1 eq) and 3-Formyl-N-pyridin-3-yl-benzamide (1.1 eq) were stirred in a mixture of MeOH/AcOH (10/1; 0.06M) for 2 h. Then NaBH 3 CN (1.2 eq) was slowly added and the mixture was stirred under argon at RT overnight. The reaction was quenched by addition of saturated NaHCO 3  solution until neutrality. MeOH and acetic acid were evaporated. The crude was filtered and washed with water and Et 2 O before being purified on reverse phase (H 2 O 1% TFA/MeCN 1% TFA 100/0, 0/100). MeCN was evaporated. The product was suspended in H 2 O and basified with saturated NaHCO 3  solution until pH=8-9. The aqueous layer was extracted three times with AcOEt. The organic layer was dried over Na 2 SO 4 , filtered and concentrated to give the expected product. 
         [0511]    Table 6 shows the compounds synthesized according to the synthesis described above in Scheme 26. 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 6 
               
             
             
               
                   
               
               
                 Compound obtained by example E 
               
             
          
           
               
                 Example 
                 Synthesized inhibitors 
               
               
                 No. 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0917 
                 3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-N-pyridin-3-yl- benzamide                            
   Yield: 48%  1 H NMR (300 MHz, DMSO-d6) δ 11.83 (s, 1H), 10.45 (s, 1H), 8.92 (s, 1H), 8.31 (d, J = 4.6, 1H), 8.18 (d, J = 7.8, 1H), 8.10 (s, 1H), 8.02 (s, 1H), 7.86 (d, J = 7.2, 1H), 7.64 (d, J = 7.2, 1H), 7.51 (t, J = 7.2, 1H), 7.39 (dd, J = 4.6, 7.8, 1H), 7.12-7.00 (m, 2H), 6.32 (t, J = 5.3, 1H), 4.42 (d, J = 5.3, 2H), 2.47 (s, 3H) HPLC: 99%; MS: 386 (M + 1) 
               
               
                   
               
               
                 OR1013 
                 3-[(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylamino)-methyl]-N-(3- trifluoromethyl-benzyl)-benzamide                            
   Yield: 48% 1H NMR (300 MHz, DMSO) δ 11.86 (s, 1H), 9.17 (t, J = 6.0, 1H), 8.13 (d, J = 2.6, 1H), 8.00 (s, 1H), 7.81 (d, J = 7.7, 1H), 7.77-7.56 (m, 5H), 7.49 (d, J = 7.7, 1H), 7.07 (dd, J = 2.3, 8.7, 2H), 6.31 (t, J = 6.0, 1H), 4.60 (d, J = 6.0, 2H), 4.40 (d, J = 6.0, 2H), 2.51 (s, 3H). HPLC: 93%; MS: 467 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example F 
     Synthesis of Compounds from Example F Derivatives 
       [0512]    General method to synthesize compounds from example F derivatives is represented by Scheme 27. 
         [0000]    
       
                 
         
             
             
         
       
     
       Step 1. General Protocol for the Preparation of Amide Derivatives of Benzoic Acid Methyl Ester 
       [0513]    3-Amino-benzoic acid methyl ester hydrochloride or 3-Aminomethyl-benzoic acid methyl ester hydrochloride (1 eq), HOBt (1.2 eq), DIEA (1.2 eq) and EDCI.HCl (1.2 eq) were dissolved in dry DMF (0.17 M) and stirred for 30 min at RT under argon. The amine derivative (1 eq) was added and the mixture was stirred at RT overnight. DMF was evaporated and saturated NaHCO 3  solution was added. Product was extracted with EtOAc, dried over Na2SO4, filtered and evaporated. The crude was purified on reverse phase chromatography to give the expected product after evaporation of solvents. 
       3-(3-Trifluoromethyl-benzoylamino)-benzoic acid methyl ester 
       [0514]    Colorless oil. Yield: 62% (660 mg). HPLC: 100%. MS: 324 (M+1) 
       3-[2-(3-Trifluoromethyl-phenyl)-acetylamino]-benzoic acid methyl ester 
       [0515]    Colorless oil. Yield: 92% (827 mg). HPLC: 98%. MS: 338 (M+1). 
       3-[(3-Trifluoromethyl-benzoylamino)-methyl]-benzoic acid methyl ester 
       [0516]    white powder. Yield: 45% (528 mg). HPLC: 93%. MS: 338 (M+1) 
       3-{[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-methyl}-benzoic acid methyl ester 
       [0517]    black powder. Yield: quantitative (1.55 g). HPLC: 91%. MS: 450 (M+1). 
       Step 2. General Protocol for the Preparation of Thioamide Derivatives 
       [0518]    A suspension of amide derivatives of benzoic acid methyl ester (528 mg) and Lawesson&#39;s reagent (“LR” in Scheme 23) (1.8 eq) in 26 mL of toluene was heated at 110° C. for 3 hours. The solvent was evaporated and saturated NaHCO 3  solution was added to the crude. Product was extracted with EtOAc, dried over Na 2 SO 4 , filtered and evaporated. The crude oil was purified on silicagel chromatography to give the expected product after evaporation of solvents. 
       3-(3-Trifluoromethyl-thiobenzoylamino)-benzoic acid methyl ester 
       [0519]    Yellow oil. Yield: 66% (460 mg). HPLC: 99%. MS: 340 (M+1) 
       3-[2-(3-Trifluoromethyl-phenyl)-thioacetylamino]-benzoic acid methyl ester 
       [0520]    White solid Yield: 49% (428 mg). HPLC: 99%. MS: 354 (M+1). 
       3-[(3-Trifluoromethyl-thiobenzoylamino)-methyl]-benzoic acid methyl ester white powder. Yield: 45% (528 mg). HPLC: 93%. MS: 338 (M+1) 
     Step 3. General Protocol for the Saponification of Methyl Ester 
       [0521]    The methyl ester (1 eq) was suspended in a mixture of solvents (THF/Water or MeOH/Water 1/1). Alcaline base (LiOH or KOH, 3 eq) was added and the mixture was heated at reflux until complete reaction (TLC control). Organic solvent was evaporated, the mixture was neutralized and the product was extracted with organic solvents. 
       3-(3-Trifluoromethyl-thiobenzoylamino)-benzoic acid 
       [0522]    Yellow solid. Yield: 91% (401 mg). HPLC: 93%. MS: 326 (M+1) 
       3-[2-(3-Trifluoromethyl-phenyl)-thioacetylamino]-benzoic acid 
       [0523]    Yield: 51% (208 mg). HPLC: 95%. MS: 340 (M+1). 
       3-[(3-Trifluoromethyl-thiobenzoylamino)-methyl]-benzoic acid 
       [0524]    yellow powder. Yield: 88% (438 mg). HPLC: 98%. MS: 340 (M+1) 
       3-{[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-methyl}-benzoic acid 
       [0525]    Yield: 54% (792 mg). HPLC: 93%. MS: 436 (M+1). 
       Step 4. General protocol for peptide like coupling reaction 
       [0526]    Acid derivative and HATU (2 eq) were dissolved in anhydrous DMF (0.1-0.2 mol/L). After 30 min, 5-Amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester (1 eq) and DIEA (3-4 eq) were added and mixture was stirred overnight at RT. DMF is evaporated and saturated NaHCO 3  solution was added. Product was extracted with EtOAc, dried over Na 2 SO 4 , filtered and evaporated. The crude was purified on reverse phase (H 2 O 1% TFA/MeCN 1% TFA 100/0, 0/100). MeCN was evaporated. The product was suspended in H2O and basified with saturated NaHCO 3  solution until pH=8-9. The aqueous layer was extracted three times with AcOEt. The organic layer was evaporated to give the final compound. 
         [0527]    Table 7 shows the compounds synthesized according to the synthesis described above in Scheme 27. 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                 Compounds obtained by example F 
               
             
          
           
               
                 Example 
                 Synthesized inhibitors 
               
               
                 No. 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR1074 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(3- trifluoromethyl-thiobenzoylamino)-benzamide                            
   Yield: 12%  1 H NMR (300 MHz, DMSO) δ 12.28 (s, 1H), 12.15 (s, 1H), 10.49 (s, 1H), 8.68 (s, 1H), 8.58 (s, 1H), 8.37 (s, 1H), 8.37 (s, 1H), 8.19-8.13 (m, 2H), 8.06 (d, J = 7.8, 1H), 7.97-7.88 (m, 2H), 7.74 (t, J = 7.8, 1H), 7.65 (t, J = 7.8, 1H), 7.39 (s, 1H), 2.57 (s, 3H) HPLC: 87 %; MS: 483 (M + 1) 
               
               
                   
               
               
                 OR1075 
                 N-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-[2-(3- trifluoromethyl-phenyl)-thioacetylamino]-benzamide                            
   Yield: 24 %  1 H NMR (400 MHz, DMSO) δ 12.27 (s, 1H), 12.07 (s, 1H), 10.47 (s, 1H), 8.66 (d, J = 2.2, 1H), 8.55 (s, 1H), 8.30 (s, 1H), 8.10 (d, J = 8.0, 1H), 7.91 (d, J = 8.0, 1H), 7.81 (s, 1H), 7.76 (d, J = 7.6, 1H), 7.68-7.55 (m, 3H), 7.39 (s, 1H), 4.23 (s, 2H), 2.57 (s, 3H) HPLC: 97%; MS: 497 (M + 1) 
               
               
                   
               
               
                 OR1012 
                 N-[3-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylcarbamoyl)- benzyl]-3-trifluoromethyl-thiobenzamide                            
   Yield: 27%  1 H NMR (300 MHz, DMSO) δ 12.27 (s, 1H), 11.09 (t, J = 5.5, 1H), 10.44 (s, 1H), 8.67 (s, 1H), 8.55 (s, 1H), 8.14-8.07 (m, 2H), 8.01 (s, 1H), 7.94 (d, J = 7.8, 1H), 7.88 (d, J = 7.8, 1H), 7.71 (t, J = 7.8, 1H), 7.62 (d, J = 7.6, 1H), 7.54 (t, J = 7.6, 1H), 7.38 (s, 1H), 5.08 (d, J = 5.5, 2H), 2.57 (s, 3H) HPLC: 97%; MS: 497 (M + 1) 
               
               
                   
               
               
                 OR0984 
                 N-[3-(2-Acetyl-1H-pyrrolo[2,3-b]pyridin-5-ylcarbamoyl)- benzyl]-4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- benzamide                            
   Yield: 20%  1 H NMR (300 MHz, DMSO) δ 12.03 (s, 1H), 10.44 (s, 1H), 9.39 (t, J = 5.7, 1H), 8.65 (d, J = 2.4, 1H), 8.53 (d, J = 2.4, 1H), 8.23 (s, 1H), 8.19 (d, J = 8.2, 1H), 7.96 (s, 1H), 7.92 (d, J = 7.8, 1H), 7.89 (d, J = 7.8, 1H), 7.55 (d, J = 8.2, 1H), 7.51 (t, J = 7.8, 1H), 7.36 (s, 1H), 4.60 (d, J = 5.7, 2H), 3.65 (s, 2H), 2.56 (s, 3H), 2.40 (bs, 4H), 2.33 (bs, 4H), 2.15 (s, 3H) HPLC: 99%; MS: 593 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example G 
     Synthesis of 5-substituted-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acids 
       [0528]    General method to synthesize 5-substituted-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid is represented by Scheme 28. 
         [0000]    
       
                 
         
             
             
         
       
     
       Step 1: Protocol for the preparation of 5-(5-amino-2-methyl-thiobenzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0529]    5-(5-amino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester, obtained according to patent WO2010092489, (1 eq) was suspended in chlorobenzene (0.06M). Lawesson&#39;s reagent (2 eq) was added and the mixture was heated at 130° C. for 2 h30. The mixture was concentrated and purified on reverse phase chromatography to give the expected product. 
         [0530]    Yellow powder, yield: 11%, ESI-MS: m/z 341 ([M+H] + ). HPLC purity: 98%. 
       Step 2: General Protocol for the Preparation of Amide Derivatives 
       [0531]    Acid derivative was dissolved in anhydrous DMF (0.06 mol/L) with DIEA (5 eq) and HATU (2 eq). After 15 min, amine derivatives (obtained according to patent WO2010092489 or according to step 1 described above) was slowly added and mixture is stirred for 12 h at RT. DMF was evaporated and NaHCO 3(aq)  was added. Product was extracted with EtOAc, dried, filtered and evaporated to obtain a dark mixture. After purification by washing with MeOH or EtOAc or by silica column, expected product was obtained as a slightly yellow or orange powder. 
       5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0532]    Yield=8%. ESI-MS: m/z 541.4 ([M+H] + ). HPLC purity: 95% 
       5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0533]    Yield=16%. ESI-MS: m/z 595.2 ([M+H] + ). HPLC purity: 94% 
       5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-benzoylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0534]    Yield=30%. ESI-MS: m/z 609.3 ([M+H] + ). HPLC purity: 99% 
       5-{5-[4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-2-methyl-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0535]    Yield=28%. ESI-MS: m/z 609.2 ([M+H] + ). HPLC purity: 95% 
       5-{5-[4-((S)-3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-2-methyl-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0536]    Yield=45%. ESI-MS: m/z 609 ([M+H] + ). HPLC purity: 99% 
       5-{2-Methyl-5-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0537]    Yield=29%. ESI-MS: m/z 563.2 ([M+H] + ). HPLC purity: 94.8% 
       5-{2-Methyl-5-[(5-trifluoromethyl-pyridine-3-carbonyl)-amino]-thiobenzoylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 
       [0538]    Yield: 48%, ESI-MS: m/z 514 ([M+H] + ). HPLC purity: 96%. 
       Step 3: General protocol for the preparation of 5-(5-benzoylamino-2-methyl-benzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid derivatives 
       [0539]    A suspension of the methyl ester derivative and potassium hydroxide (5 eq) in a mixture (50/50) of water and methanol was heated at 65° C. for 18 hours. Methanol was evaporated and the pH neutralized to pH 7 by HCl 6N. After evaporation of the solvent, the crude residue was purified by silica gel chromatography (water/acetonitrile) to give a brown solid. 
         [0540]    Table 8 shows the compounds synthesized according to the synthesis Scheme 28 described above. 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                 Compounds obtained by example G 
               
             
          
           
               
                   
                 Synthesized inhibitors 
               
               
                 Example No. 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR0692 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]- benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid                            
   Yield: 76%  1 H NMR (300 MHz, DMSO) δ 11.77 (s, 1H), 10.10 (s, 1H), 8.05 (d, J = 2.4, 1H), 7.86 (d, J = 8.1, 2H), 7.68 (s, 1H), 7.65 (d, J = 8.2, 1H), 7.39 (d, J = 8.1, 2H), 7.16 (d, J = 8.2, 1H), 6.98 (d, J = 2.4, 1H), 6.80 (s, 1H), 5.97 (bs, 1H), 4.21 (s, 2H), 3.51 (s, 2H), 2.38 (bs, 8H), 2.32 (s, 3H), 2.19 (s, 3H) HPLC: 98%; MS: 513 (M + 1) 
               
               
                   
               
               
                 OR0623 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid                            
   Yield: 54%  1 H NMR (300 MHz, DMSO) δ 11.24 (s, 1H), 10.39 (s, 1H), 8.20 (s, 1H), 8.18 (d, J = 7.8, 1H), 7.94 (d, J = 2.5, 1H), 7.87 (d, J = 7.8, 1H), 7.71- 7.64 (m, 2H), 7.18 (d, J = 8.8, 1H), 6.95 (d, J = 2.5, 1H), 6.54 (s, 1H), 5.84 (bs, 1H), 4.21 (s, 2H), 3.65 (s, 2H), 2.40 (sb, 8H), 2.33 (s, 3H), 2.16 (s, 3H) HPLC: 99%; MS: 581 (M + 1) 
               
               
                   
               
               
                 OR0810 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-benzoylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid                            
   Yield: 74%  1 H NMR (300 MHz, DMSO) δ 12.15 (s, 1H), 10.55 (s, 1H), 10.47 (s, 1H), 8.56 (s, 1H), 8.54 (s, 1H), 8.34-8.18 (m, 2H), 8.03-7.77 (m, 3H), 7.32 (d, J = 7.7, 1H), 7.05 (s, 1H), 3.69 (s, 2H), 2.46-2.32 (m, 11H), 2.21 (s, 3H) HPLC: 99%; MS: 595 (M + 1) 
               
               
                   
               
               
                 OR0528 
                 5-{5-[4-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-2-methyl-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2- carboxylic acid                            
   Yield: 28%  1 H NMR (300 MHz, DMSO) δ 11.70 (s, 1H), 10.37 (s, 1H), 8.22-8.12 (m, 2H), 8.03 (s, 1H), 7.85 (d, J = 8.0, 1H), 7.66 (bs, 2H), 7.19 (d, J = 8.4, 1H), 6.96 (s, 1H), 6.75 (s, 1H), 6.01 (s, 1H), 4.22 (s, 2H), 3.80 (d, J = 14.5, 1H), 3.72 (d, J = 14.5, 1H), 2.98-2.79 (m, 1H), 2.71-2.52 (m, 3H), 2.47-2.40 (m, 1H), 2.33 (s, 3H), 2.16 (s, 6H), 1.97-1.82 (m, 1H), 1.76-1.61 (m, 1H) HPLC: 95%; MS: 595 (M + 1) 
               
               
                   
               
               
                 OR0814 
                 5-{5-[4-((S)-3-Dimethylamino-pyrrolidin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-2-methyl-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2- carboxylic acid                            
   Yield: 68%  1 H NMR (300 MHz, DMSO) δ 11.71 (s, 1H), 10.35 (s, 1H), 8.19 (s, 1H), 8.17 (d, J = 8.0, 1H), 8.04 (s, 1H), 7.85 (d, J = 8.0, 1H), 7.71-7.60 (m, 2H), 7.19 (d, J = 8.6, 1H), 6.97 (s, 1H), 6.77 (s, 1H), 5.99 (s, 1H), 4.22 (s, 2H), 3.80 (d, J = 15.3, 1H), 3.72 (d, J = 15.3, 1H), 2.89-2.76 (m, 1H), 2.70-2.53 (m, 3H), 2.45-2.35 (m, 1H), 2.33 (s, 3H), 2.13 (s, 6H), 1.97- 1.81 (m, 1H), 1.73-1.59 (m, 1H) HPLC: 99%; MS: 595 (M + 1) 
               
               
                   
               
               
                 OR0653 
                 5-{2-Methyl-5-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl- benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid                            
   Yield: 64%  1 H NMR (400 MHz, DMSO) δ 11.85 (s, 1H), 10.52 (s, 1H), 9.54 (s, 1H), 8.55 (s, 1H), 8.37 (s, 2H), 8.12 (s, 1H), 8.07 (d, J = 2.3, 1H), 7.69 (s, 1H), 7.68-7.64 (d, J = 8.2, 1H), 7.23 (d, J = 8.2, 1H), 6.98 (s, 1H), 6.83 (d, J = 2.3, 1H), 6.11 (bs, 1H), 4.26 (s, 2H), 2.35 (s, 3H), 2.33 (s, 3H) HPLC: 98%; MS: 549 (M + 1) 
               
               
                   
               
               
                 OR1053 
                 5-{2-Methyl-5-[(5-trifluoromethyl-pyridine-3-carbonyl)-amino]- thiobenzoylamino}-1H-pyrrolo[2,3-blpyridine-2-carboxylic acid.                            
   Yield: 15%  1 H NMR (400 MHz, DMSO) δ 12.49-12.39 (m, 1H), 12.05 (s, 1H), 10.69 (s, 1H), 9.41-9.38 (m, 1H), 9.20 (s, 1H), 8.75-8.71 (m, 1H), 8.62 (d, J = 2.3 Hz, 1H), 8.59 (d, J = 2.3 Hz, 1H), 7.82-7.75 (m, 2H), 7.31 (d, J = 9.1 Hz, 1H), 7.15 (s, 1H), 2.39 (s, 3H). HPLC: 95%; MS: 500 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Example H 
     Synthesis of 5-substituted-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acids 
       [0541]    General method to synthesize 5-substituted-1H-pyrrolo[2,3-b]pyridine-2-carboxilic acid is represented by Scheme 29. 
         [0000]    
       
                 
         
             
             
         
       
     
       General Protocol for Amidation Step 
       [0542]    The acid derivative (1 eq) was dissolved in DMF (0.1M) with alkylamine (5 eq), DIEA (3 eq), HOBt (1.2 eq) and EDCI.HCl (1.2 eq). The mixture was heated by microwave irradiation at 140° C. for 5 min. The mixture was concentrated and washed with NaHCO 3  saturated solution. The precipitate was filtered. The crude product was purified on reverse phase to give the final product. 
         [0543]    Table 9 shows the compounds synthesized according to the synthesis described above. 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                 Compounds obtained by example H 
               
             
          
           
               
                   
                 Synthesized inhibitors 
               
               
                 Example No. 
                 (mass and analytical data) 
               
               
                   
               
               
                 OR1069 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid hexylamide                            
   Yield: 50%  1 H NMR (400 MHz, DMSO) δ 11.51 (s, 1H), 10.34 (s, 1H), 8.34-8.14 (m, 3H), 7.98 (s, 1H), 7.87 (d, J = 7.9, 1H), 7.77-7.55 (m, 2H), 7.19 (d, J = 8.1, 1H), 6.99 (s, 1H), 6.80 (s, 1H), 5.91 (t, J = 5.1 1H), 4.23 (d, J = 5.1, 2H), 3.68 (s, 2H), 3.30-3.10 (m, 2H), 2.50-2.41 (m, 8H), 2.33 (broad s, 6H), 1.55-1.45 (m, 2H), 1.28 (s, 6H), 0.86 (t, J = 6.2, 3H). HPLC: &gt;99%; MS: 664 (M + 1) 
               
               
                   
               
               
                 OR1076 
                 5-{2-Methyl-5-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- benzoylamino]-benzylamino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid diethylamide                            
   Yield: 33%  1 H NMR (400 MHz, DMSO) δ 11.51 (s, 1H), 10.33 (s, 1H), 8.20-8.13 (m, 2H), 7.97 (d, J = 1.4, 1H), 7.87 (d, J = 8.1, 1H), 7.68-7.63 (m, 2H), 7.19 (d, J = 7.9, 1H), 6.95 (s, 1H), 6.47 (s, 1H), 5.96 (t, J = 5.1, 1H), 4.23 (d, J = 5.1, 2H), 3.65 (s, 2H), 3.55-3.43 (m, 4H), 2.45-2.33 (m, 8H), 2.33 (s, 3H), 2.16 (s, 3H), 1.16 (t, J = 6.7, 6H). HPLC: &gt;99%; MS: 636 (M + 1) 
               
               
                   
               
             
          
         
       
     
       Material and Methods: 
       [0544]    1) In Vitro Kinase Assays (Table 10 to Table 21) 
         [0545]    The inhibitory activity of the compounds on several kinases including BRAF, EGFR (ErbB1), EGFR (ErbB1) T790M L858R, FGFR2, KDR (VEGFR2), PDGFRA (PDGFR alpha), SRC and other was evaluated by Invitrogen using the Z′-LYTE® technology. Briefly, the Z′-LYTE® biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and non-phosphorylated peptides to proteolytic cleavage. The peptide substrate is labeled with two fluorophores-one at each end—that make up a FRET pair. A ratiometric method, which calculates the ratio (the Emission Ratio) of donor emission to acceptor emission after excitation of the donor fluorophore at 400 nm, is used to quantitate reaction progress. 
         [0546]    The compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold serial dilutions are conducted from the starting concentration. All Peptide/Kinase Mixtures are diluted to a 2× working concentration in the appropriate Kinase Buffer. All ATP Solutions are diluted to a 4× working concentration in Kinase Buffer (50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl 2 , 1 mM EGTA). ATP Km apparent is previously determined using a Z′-LYTE® assay. 
         [0547]    Each compound was incubated at a concentration of 100 nM (excepted to test the activity against ABL and ABL T315I for which the compounds were incubated at a concentration of 10 μM) and the tables 10 to 21 summarize the results obtained showing the inhibitory power of a compound. 
         [0548]    2) In Vitro Cell Proliferation Assays (Table 22 to Table 35) 
         [0549]    Cancer cell lines (5×10 3  cells per well) or HUVEC (1×10 4  cells per well) or HRMEC (1×10 4  cells per well) were distributed in 96-well plates and incubating in duplicate with escalating concentrations (10 nM to 3 μM) of compounds for 72 hr. Cell proliferation was measured using MTT (3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide). The EC50 values were calculated from sigmoidal dose-response curves utilizing Prism 5.0 from Graph-Pad Software (GraphPad Software, La Jolla, Calif., USA), with values normalized to those of DMSO-treated control wells (0%) and 1% SDS control wells (100%). 
         [0550]    3) in vivo studies (table 36) 
         [0551]    Human hepatocellular carcinoma mouse model was prepared by subcutaneously implanting HepG2 cells (1×10 7  cell/mL in sterile PBS), into the right flank of athymic nude male mice (HSD, 6-7 weeks old). When the tumor volume reached approximately 200 mm 3 , mice were assigned randomly to either vehicle alone or ORB compounds treatment groups (six mice per group). Mice were treated with either vehicle (PEG400) or OR0720, OR0721, OR0811 (20 mg/kg q.d.; per os for 15 consecutive days). 
         [0552]    Tumor volumes in mm 3  were determined three times a week with a digital caliper and calculated using the following formula: Tumor Volume (mm)=length (mm)×width (mm)×width (mm)×½. Body weight was measured three times a week, and mice were observed daily for monitoring signs of stress to detect possible toxicities. One-way ANOVA was used for statistical comparisons. Data were analyzed with Prism 5.0 b (GraphPad Software) by one-way ANOVA with Bonferroni post hoc. Tumor Growth Inhibition (TGI) is calculated as the percent decrease of tumor growth at the end of the study in the ORB compounds treatment groups in comparison to the vehicle alone treatment group. 
       Biological Results: 
       [0553]    The in vitro kinase assays reveal several kinase-inhibiting molecular structures. More than 15 compounds are able to inhibit at least 4 of the kinases tested (IC50 expected to be less than 100 nM on each of these kinases as the inhibition percent is better than 50% at the concentration of 100 nM, excepted for ABL and ABL T315I for which IC50 are expected to be less than 10 μM). It should be noted that these compounds display inhibitory activity on kinases that represent different and distant kinase families (serine/threonine or tyrosine kinases) involved in multiple pathways in tumor progression as developed in the introduction part (angiogesesis, migration, metastatis, tumor growth . . . ). These compounds are multi-targeted kinase inhibitors with large spectrum. The results obtained are presented in Table 10 to Table 21. 
         [0554]    The anti-proliferative potency of compounds was evaluated either on malignant cancer cell lines or on primary endothelial cells mimicking the angiogenesis process. The EC50 corresponding to the concentration of compound inhibiting cell growth at a level of 50% were determined. The results obtained are presented in Table 22 to Table 35. 
         [0555]    We consider in those experiments that compounds presenting an EC50 superior than 3 μM are inactive on the tested cell types. Compounds with an EC50 between 1 μM and 3 μM are considered active, as Sorafenib, which is currently marketed to treat hepatocellular carcinoma, presents here an EC50 between 1 μM and 3 μM on 4 liver cancer cell lines (HepG2, HuH7, HuCCT1 and HuH6 Clone 5). Several compounds are highly potent inhibitors of the cellular growth in each cell types tested and present antiangiogenic properties on HUVEC. For all the other cancer cell lines, several compounds highly inhibit the cell growth. Taken together, these results indicate that the compounds of the invention are able to block at least two pathways of the tumor growth (epithelial cell proliferation and angiogenesis). 
         [0556]    In vivo, in xenografted mice bearing human hepatocellular carcinoma tumors, OR0720, OR0721 and OR0811 significantly induced a decrease of tumor growth. The results obtained are presented in Table 36. 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 10 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 BRAF 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0528, OR0623, OR0653, OR0692, 
                 OR0718, OR0719, OR0720, OR0721, 
               
               
                 OR0780, OR0782, OR0734, OR0810, 
                 OR0751, OR0752, OR0753, OR0781, 
               
               
                 OR0814, OR0886, OR0890, OR0891, 
                 OR0811, OR0813, OR0885, OR0887, 
               
               
                 OR0895, OR0917, OR0926, OR0927, 
                 OR0888, OR0889, OR0893, OR0894, 
               
               
                 OR0928, OR0929, OR0930, OR0949, 
                 OR0897, OR0950, OR0968, OR0970, 
               
               
                 OR0951, OR0971, OR0972, OR0984, 
                 OR0973, OR0979, OR0980, OR0986, 
               
               
                 OR0988, OR1012, OR1015, OR1053   
                 OR0987 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 11 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 EGFR (ErbB1) 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0719, OR0721, OR0780, OR0887, 
                 OR0528, OR0623, OR0653, OR0692, 
               
               
                 OR0888, OR0889, OR0891, OR0894, 
                 OR0718, OR0720, OR0751, OR0752, 
               
               
                 OR0895, OR0897, OR0929, OR0930, 
                 OR0753, OR0781, OR0782, OR0734, 
               
               
                 OR0950, OR0951, OR0968, OR0970, 
                 OR0810, OR0811, OR0813, OR0814, 
               
               
                 OR0979, OR0980, OR0984, OR0986, 
                 OR0885, OR0890, OR0893, OR0917, 
               
               
                 OR0987, OR0988, OR1012, OR1015  
                 OR0926, OR0927, OR0928, OR0949, 
               
               
                   
                 OR1053, OR0971, OR0972, OR0973  
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 12 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 EGFR (ErbB1) T790M L858R 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0692, OR0719, OR0721, OR0780, 
                 OR0528, OR0623, OR0653, OR0718, 
               
               
                 OR0782 
                 OR0720, OR0751, OR0752, OR0753, 
               
               
                   
                 OR0781 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 13 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 FGFR2 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0653, OR0692, OR0719, OR0721, 
                 OR0528, OR0623, OR0718, OR0720, 
               
               
                 OR0753, OR0780, OR0734, OR0886, 
                 OR0751, OR0752, OR0781, OR0782, 
               
               
                 OR0887, OR0888, OR0889, OR0890, 
                 OR0810, OR0811, OR0813, OR0814, 
               
               
                 OR0891, OR0893, OR0895, OR0897, 
                 OR0885, OR0894, OR0917, OR0926, 
               
               
                 OR0929, OR0930, OR0950, OR0951, 
                 OR0927, OR0928, OR0949, OR0971, 
               
               
                 OR0968, OR0970, OR0973, OR0979, 
                 OR0972 
               
               
                 OR0980, OR0984, OR0986, OR0987, 
                   
               
               
                 OR0988, OR1012, OR1015, OR1053  
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 14 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 KDR (VEGFR2) 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0719, OR0780, OR0886, OR0889, 
                 OR0528, OR0623, OR0653, OR0692, 
               
               
                 OR0890, OR0891, OR0895, OR0897, 
                 OR0718, OR0720, OR0721, OR0751, 
               
               
                 OR0929, OR0930, OR0951, OR0968, 
                 OR0752, OR0753, OR0781, OR0782, 
               
               
                 OR0979, OR0980, OR0984, OR0986, 
                 OR0734, OR0810, OR0811, OR0813, 
               
               
                 OR0988, OR1012, OR1015, OR1053  
                 OR0814, OR0885, OR0887, OR0888, 
               
               
                   
                 OR0893, OR0894, OR0917, OR0926, 
               
               
                   
                 OR0927, OR0928, OR0949, OR0950, 
               
               
                   
                 OR0970, OR0971, OR0972, OR0973, 
               
               
                   
                 OR0987 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 15 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 PDGFRA (PDGFR alpha) 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0719, OR0891, OR0929, OR0930, 
                 OR0528, OR0623, OR0653, OR0692, 
               
               
                 OR0951, OR0984, OR0988, OR1012, 
                 OR0718, OR0720, OR0721, OR0751, 
               
               
                 OR1015 
                 OR0752, OR0753, OR0780, OR0781, 
               
               
                   
                 OR0782, OR0734, OR0886, OR0888, 
               
               
                   
                 OR0889, OR0890, OR0895, OR0897, 
               
               
                   
                 OR0950, OR0968, OR0979, OR0980, 
               
               
                   
                 OR0986, OR0987, OR1053 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 16 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM using an ATP Km apparent 
               
               
                 concentration. The activity is represented by the % of inhibition of the kinase compared 
               
               
                 to the control. 
               
               
                 SRC 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0780, OR0886, OR0889, OR0891, 
                 OR0528, OR0623, OR0653, OR0692, 
               
               
                 OR0895, OR0897, OR0929, OR0930, 
                 OR0718, OR0719, OR0720, OR0721, 
               
               
                 OR0950, OR0951, OR0968, OR0979, 
                 OR0751, OR0752, OR0753, OR0781, 
               
               
                 OR0980, OR0984, OR0986, OR0987, 
                 OR0782, OR0734, OR0888, OR0890, 
               
               
                 OR0988, OR1012, OR1015 
                 OR1053 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 17 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 10 μM  
               
               
                 using an ATP Km apparent concentration. The activity is represented  
               
               
                 by the % of inhibition of the kinase compared to the control. 
               
               
                 ABL 
               
             
          
           
               
                   
                 &lt;50% 
                 ≧50% 
               
               
                   
                   
               
               
                   
                   
                 OR0528, OR0623, OR0653 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 18 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 10 μM  
               
               
                 using an ATP Km apparent concentration. The activity is represented  
               
               
                 by the % of inhibition of the kinase compared to the control. 
               
               
                 ABL T315I 
               
             
          
           
               
                 &lt;50% 
                 ≧50% 
               
               
                   
               
               
                 OR0653 
                 OR0528, OR0623 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 19 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM  
               
               
                 using an ATP Km apparent concentration. The activity is represented  
               
               
                 by the % of inhibition of the kinase compared to the control. 
               
               
                 FGFR1 
               
             
          
           
               
                   
                 &lt;50% 
                 ≧50% 
               
               
                   
                   
               
               
                   
                 OR0653 
                 OR0623 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 20 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM  
               
               
                 using an ATP Km apparent concentration. The activity is represented  
               
               
                 by the % of inhibition of the kinase compared to the control. 
               
               
                 VEGFR1 
               
             
          
           
               
                   
                 &lt;50% 
                 ≧50% 
               
               
                   
                   
               
             
          
           
               
                   
                 OR0623, OR0653 
                   
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 21 
               
             
             
               
                   
               
               
                 In vitro kinase assays. Each compound was incubated at 100 nM  
               
               
                 using an ATP Km apparent concentration. The activity is represented  
               
               
                 by the % of inhibition of the kinase compared to the control. 
               
               
                 PDGFRB 
               
             
          
           
               
                   
                 &lt;50% 
                 ≧50% 
               
               
                   
                   
               
               
                   
                 OR0653 
                 OR0623 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 22 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on A549 cell line. 
               
               
                 A549 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0720, OR0813 
                 OR0718, OR0811, OR0926,  
                 OR0528, OR0623,  
               
               
                   
                 OR0928, OR0972, OR0751,  
                 OR0653, OR0721,  
               
               
                   
                 OR0752, OR1060, OR1076 
                 OR0753, OR0780,  
               
               
                   
                   
                 OR0781, OR0782,  
               
               
                   
                   
                 Erlotinib, OR0885,  
               
               
                   
                   
                 OR1012, OR1015,  
               
               
                   
                   
                 OR1053, OR1056,  
               
               
                   
                   
                 OR1058, OR1063 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 23 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HepG2 cell line. 
               
               
                 HepG2 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0720, OR0721,  
                 OR0752, OR0718, OR0752,  
                 OR0623, OR0753,  
               
               
                 OR0751, OR0811,  
                 OR0885, OR0890, OR0891, 
                 OR0781, OR0782,  
               
               
                 OR0813, OR0893,  
                 OR0895, OR0927, OR0928,  
                 Dasatinib, OR0528, 
               
               
                 OR0897, OR0926,  
                 OR0949, OR0950, OR0968, 
                 OR0886, OR0888,  
               
               
                 OR0951, OR0972,  
                 OR0970, OR0971, OR0973,  
                 OR0889, OR0917,  
               
               
                 OR1060 
                 OR0980, OR1015, OR1069 
                 OR0929, OR0930,  
               
               
                   
                   
                 OR0979, OR0984,  
               
               
                   
                   
                 OR0986, OR0987,  
               
               
                   
                   
                 OR0988, OR1012,  
               
               
                   
                   
                 OR1053, OR1056,  
               
               
                   
                   
                 OR1058, OR1063 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 24 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HuCCT1 cell line. 
               
               
                 HuCCT1 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                   
                 OR0752, OR0718, OR0720,  
                 Dasatinib, OR0721,  
               
               
                   
                 OR0751 
                 OR0753, OR0781,  
               
               
                   
                   
                 OR0782 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 25 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HuH6 Clone 5 cell line. 
               
               
                 HuH6 Clone 5 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                   
                 OR0751, OR0752, OR0753,  
                 OR0781, OR0782,  
               
               
                   
                 OR0718, OR0720, 
                 OR0721, 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 26 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HuH7 cell line. 
               
               
                 HuH7 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0751 
                 OR0718, OR0720, OR0721,  
                 OR0753, OR0782,  
               
               
                   
                 OR0752, OR0781, OR0811 
                 OR0734 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 27 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HT29 cell line. 
               
               
                 HT29 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0720, OR0751 
                 OR0752, OR0718, OR0811 
                 OR0623, OR0721,  
               
               
                   
                   
                 OR0780, OR0781,  
               
               
                   
                   
                 OR0782, OR0528 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 28 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on BxPC-3 cell line. 
               
               
                 BxPC-3 
               
             
          
           
               
                   
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
                   
               
               
                   
                 OR0718, OR0720 
                 OR0721, OR0811 
                 OR0528, OR0623,  
               
               
                   
                   
                   
                 OR0653 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 29 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on H1975 cell line. 
               
               
                 H1975 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                   
                 OR0752, OR0781, OR0718,  
                 OR0623, OR0721,  
               
               
                   
                 OR0720, OR0751 
                 OR0780, OR0782,  
               
               
                   
                   
                 OR0528, OR0811 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 30 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HUVEC cell line. 
               
               
                 HUVEC 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0752, OR0718,  
                 OR0721, OR0781, OR0811,  
                 OR0623, OR0780,  
               
               
                 OR0720, OR0751,  
                 OR0886, OR0887, OR0888,  
                 OR0782, OR0753,  
               
               
                 OR0813 
                 OR0889, OR0890, OR0891, 
                 OR0885, OR0894, 
               
               
                   
                 OR0893, OR0926, OR0927,  
                 OR0895, OR0897,  
               
               
                   
                 OR0928, OR0949, OR0972, 
                 OR0917, OR0929,  
               
               
                   
                 OR1015, OR1060, OR1069 
                 OR0930, OR0950, 
               
               
                   
                   
                 OR0951, OR0968,  
               
               
                   
                   
                 OR0970, OR0971,  
               
               
                   
                   
                 OR0973, OR0979, 
               
               
                   
                   
                 OR0980, OR0986,  
               
               
                   
                   
                 OR0987, OR0988,  
               
               
                   
                   
                 OR1012, OR1053, 
               
               
                   
                   
                 OR1056, OR1058, 
               
               
                   
                   
                 OR1063 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 31 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on PC3 cell line. 
               
               
                 PC3 
               
             
          
           
               
                   
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
                   
               
               
                   
                 OR0720 
                 OR0721, OR0811 
                   
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 32 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on Caki2 cell line. 
               
               
                 Caki-2 
               
             
          
           
               
                   
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
                   
               
               
                   
                   
                 OR0720, OR0811 
                 OR0721 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 33 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on MDA-MB-231 cell line. 
               
               
                 MDA-MB-231 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                 OR0718, OR0720,  
                 OR0721, OR0811, OR0813,  
                 OR1012, OR1015,  
               
               
                 OR0751, OR0926,  
                 OR0885, OR1060, OR1069 
                 OR1053, OR1056,  
               
               
                 OR0928, OR0972 
                   
                 OR1058, OR1063 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 34 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HeLa cell line. 
               
               
                 HeLa 
               
             
          
           
               
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
               
               
                   
                 OR0718, OR0720, OR0926,  
                 OR0751, OR0813,  
               
               
                   
                 OR0928, OR0972 
                 OR0885, OR1012,  
               
               
                   
                   
                 OR1015, OR1056, 
               
               
                   
                   
                 OR1058, OR1060,  
               
               
                   
                   
                 OR1063, OR1069 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 35 
               
             
             
               
                   
               
               
                 Anti-proliferative activity of the compounds of the invention  
               
               
                 on HRMEC cells. 
               
               
                 HRMEC 
               
             
          
           
               
                   
                 EC 50  ≦ 100 nM 
                 100 nM &lt; EC50 &lt; 1 μM 
                 EC 50  ≧ 1 μM 
               
               
                   
                   
               
               
                   
                 OR0720, OR0751,  
                 OR0718, OR0811, OR0813 
                 OR0721 
               
               
                   
                 OR0752 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 36 
               
             
             
               
                   
               
               
                 Anti-tumor activity (Tumor Growth Inhibition—TGI) of OR0720,  
               
               
                 OR0721 and OR0811 in a mouse model of hepatocellular carcinoma.  
               
               
                 Mice groups (n = 6) were orally and daily dosed with either vehicle  
               
               
                 alone (PEG400) or each OR compound.  
               
             
          
           
               
                   
                 Cancer type 
                 Hepatocellular carcinoma 
               
               
                   
                 Implanted Cells 
                 HepG2 
               
               
                   
                   
               
               
                   
                 OR0720 
                 66%* 
               
               
                   
                 OR0721 
                 54%* 
               
               
                   
                 OR0811 
                 75%* 
               
               
                   
                   
               
               
                   
                 **P &lt; 0.05 versus vehicle-treated group.