Abstract:
The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence&#39; and/or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of  M. tuberculosis  strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the  Mycobacterium tuberculosis,  the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.

Description:
FIELD OF INVENTION  
       [0001]     The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases including tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence and/or infectivity in infectious diseases by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of  M. tuberculosis  strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence.  
         [0002]     Although the present invention has been illustrated with specific reference to the polymorphic region in the  Mycobacterium tuberculosis,  the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.  
       BACKGROUND OF THE INVENTION  
       [0003]     Microbial pathogens use a variety of complex strategies to subvert host cellular functions to ensure their multiplication and survival. Some pathogens that have co-evolved or have had a long-standing association with their hosts utilize finely tuned host-specific strategies to establish a pathogenic relationship.  
         [0004]     During infection, pathogens encounter different conditions, and respond by expressing virulence factors that are appropriate for the particular environment, host, or both.  
         [0005]     Although antibiotics have been effective tools in treating infectious disease, the emergence of drug resistant pathogens is becoming problematic in the clinical setting. New antibiotic or antipathogenic molecules are therefore needed to combat such drug resistant pathogens. Accordingly, there is a need in the art for screening methods aimed not only at identifying and characterizing potential antipathogenic agents, but also for identifying and characterizing the virulence factors that enable pathogens to infect and debilitate their hosts.  
         [0006]     The mycobacteria are rod-shaped, acid-fast, aerobic bacilli that do not form spores. Several species of mycobacteria are pathogenic to humans and/or animals, and factors associated with their virulence. Tuberculosis is a worldwide health problem, which causes approximately 3 million deaths each year, yet little is known about the molecular basis of tuberculosis pathogenesis. The disease is caused by infection with  Mycobacterium tuberculosis;  tubercle bacilli are inhaled and then ingested by alveolar macrophages. As is the case with most pathogens, infection with  M. tuberculosis  does not always result in disease. The infection is often arrested by developing cell-mediated immunity (CMI) resulting in the formation of microscopic lesions, or tubercles, in the lung. If CMI does not limit the spread of  M. tuberculosis,  caseous necrosis, bronchial wall erosion, and pulmonary cavitations may occur. The factors that determine whether infection with  M. tuberculosis  results in disease are not well understood.  
         [0007]     The tuberculosis complex is a group of four mycobacterial species that are so closely related genetically that it has been proposed treat they or combined into a single species. Three important members of the complex are  Mycobacterium tuberculosis,  the major cause of human tuberculosis;  Mycobacterium africanum,  a major cause of human tuberculosis in some populations; and  Mycobacterium bovis,  the cause of bovine tuberculosis. None of these mycobacteria is restricted to being pathogenic for a single host species. For example,  M. bovis  causes tuberculosis in a wide range of animals including humans in which it causes a disease that is clinically indistinguishable from that caused by  M. tuberculosis.  Human tuberculosis is a major cause of mortality throughout the world, particularly in less developed countries. It accounts for approximately eight million new cases of clinical disease and three million deaths each year. Bovine tuberculosis, as well as causing a small percentage of these human cases, is a major cause of animal suffering and large economic costs in the animal industries.  
         [0008]     Antibiotic treatment of tuberculosis is very expensive and requires prolonged administration of a combination of several anti-tuberculosis drugs. Treatment with single antibiotics is not advisable as tuberculosis organisms can develop resistance to the therapeutic levels of all antibiotics that are effective against them. Strains of  M. tuberculosis  that are resistant to one or more anti-tuberculosis drugs are becoming more frequent and treatment of patients infected with such strains is expensive and difficult. In a small but increasing percentage of human tuberculosis cases the tuberculosis organisms have become resistant to the two most useful antibiotics, isoniazid and rifampicin. Treatment of these patients presents extreme difficulty and in practice is often unsuccessful. In the current situation there is clearly an urgent need to develop new methods for detecting virulent strains of mycobacteria and to develop tuberculosis therapies.  
         [0009]     There is a recognized vaccine for tuberculosis, which is an attenuated form of  M. bovis  known as BCG. This is very widely used but it provides incomplete protection. The development of BCG was completed in 1921 but the reason for its avirulence was and has continued to remain unknown. Methods of attenuating tuberculosis strains to produce a vaccine in a more rational way have been investigated but have not been successful for a variety of reasons. However, in view of the evidence that dead  M. bovis  BCG was less effective in conferring immunity than live BCG, there exists a need for attenuated strains of mycobacteria that can be used in the preparation of vaccines.  
         [0010]     A variety of compounds have been proposed as virulence factors for tuberculosis but, despite numerous investigations, good evidence to support these proposals is lacking. Nevertheless, the discovery of a virulence factor or factors for tuberculosis is very important and is an active area of current research. Such a discovery would not only enable the possible development of a new generation of tuberculosis vaccines but might also provide a target for the design or discovery of new or improved anti-tuberculosis drugs or therapies.  
         [0011]     Present methods for the identification and characterization of mycobacteria in samples from human and animal diseases are by Zeil-Neilson staining, in-vitro and in vivo culture, biochemical testing and serological typing. These methods are generally slow and do not readily discriminate between closely related mycobacterial strains and species particularly, for example, Mycobacterium paratuberculosis  and  Mycobacterium avium.  Mycobacteria are widespread in the environment, and rapid methods do not exist for the identification of specific pathogenic strains from amongst the many environmental strains, which are generally non-pathogenic. Difficulties with existing methods of mycobacterial identification and characterization have increased relevance for the analysis of microbial isolates from Crohn&#39;s disease (Regional Ileitis) in humans and Johne&#39;s disease in animals (particularly cattle, sheep and goats) as well as for  M. avium  strains from AIDS patients with mycobacterial superinfections. Although recognition of the causative agents of human leprosy and tuberculosis are clear, clinico-pathological forms of each disease exist, such as the tuberculoid form of leprosy, in which mycobacterial tissue abundance is low and identification correspondingly difficult. Improvements in the specific recognition and characterization of mycobacteria may also increase in relevance if current evidence linking diseases such as rheumatoid arthritis to mycobacterial antigens is substantiated. Emerging drug resistance to mycobacteria including  M. avium  isolates from AIDS patients, any Mycobacterium tuberculosis from TB patients is an increasing problem.  
         [0012]     There is no data or technical information in the prior art, which permits to select specifically potential new targets and protective antigens for new drugs and vaccine compositions to treat and prevent infectious diseases, particularly tuberculosis. Furthermore, there is a need for the development of new tools for the selection of genes which encode for essential proteins or regulatory nucleotidic sequences in the survival or infection of mycobacterium species and useful for the design of anti-tuberculosis drugs and vaccines based on the knowledge of comparative mycobacterial genomics.  
         [0013]     A method of using DNA probes for the precise identification of mycobacteria and discrimination between closely related mycobacterial strains and species by genotype characterization is essential. The method of genotypic analysis is further applicable to the rapid identification of phenotypic properties such as drug resistance and pathogenicity.  
         [0014]     The invention aids in fulfilling these needs in the art. The method according to the invention has the advantage to reduce drastically the number of potential new targets and protective antigens by giving for the first time an exhaustive description of conserved SNPs in the tuberculosis. The isolated polynucleotides described in the present invention, which are highly conserved in genomic sequences of both virulent and avirulent, are by this characteristic essential for the survival or the virulence of these mycobacteria in the host. The identification of antigens and potentially therapeutic targets has been made by a method of comparative genomic analysis.  
       PRIOR ART  
       [0015]     Patent application WO 02074903 describes a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the survival or the virulence of mycobacterium species by a comparative genomic analysis of the sequence of the genome of  M. tuberculosis  aligned on the genome sequence of  M. leprae  and  M. tuberculosis  and  M. leprae  marker polypeptides of nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.  
         [0016]     U.S. Pat. No. 6,228,575 provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tuberculosis, rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.  
         [0017]     Patent application No. WO9954487 and U.S. Pat. No. 6,492,506 describes a method for isolating a polynucleotide of interest that is present or is expressed in a genome of a first mycobacterium strain and that is absent or altered in a genome of a second mycobacterium strain which is different from the first mycobacterium strain using a bacterial artificial chromosome (BAC) vector. This invention further relates to a polynucleotide isolated by this method and recombinant BAC vector used in this methQd. In addition the present invention comprises method and kit for detecting the presence of a mycobacteria in a biological sample.  
         [0018]     U.S. Pat. No. 5,783,386 describes polynucleotides associated with virulence in mycobacteria, and particularly a fragment of DNA isolated from  M. bovis  that contains a region encoding a putative sigma factor. Also provided are methods for a DNA sequence or sequences associated with virulence determinants in mycobacteria, and particularly in  M. tuberculosis  and  M. bovis.  In addition, the invention provides a method for producing strains with altered virulence or other properties, which can themselves be used to identify and manipulate individual genes.  
         [0019]     U.S. Pat. No. 5,955,077 relates to novel antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in memory immune animals after rechallenge infection with mycobacteria of the tuberculosis complex. The antigens of the invention are believed useful especially in vaccines, but also in diagnostic compositions, especially for diagnosing infection with virulent mycobacteria. Also disclosed are nucleic acid fragments encoding the antigens as well as methods of immunizing animals/humans and methods of diagnosing tuberculosis.  
         [0020]     U.S. Pat. No. 6,596,281 describes two genes for proteins of  M. tuberculosis  have been sequenced. The DNAs and their encoded polypeptides can be used for immunoassays and vaccines. Cocktails of at least three purified recombinant antigens, and cocktails of at least three DNAs encoding them can be used for improved assays and vaccines for bacterial pathogens and parasites.  
         [0021]     U.S. Pat. No. 5,700,683 provides specific genetic deletions that result in an avirulent phenotype of a mycobacterium. These deletions may be used as phenotypic markers of providing a means for distinguishing between disease-producing and non-disease producing mycobacteria.  
         [0022]     U.S. Pat. No. 5,225,324 relates to a family of DNA insertion sequences (ISMY) of mycobacterial origin and other DNA probes which may be used a probes in assay methods for the identification of mycobacteria and the differentiation between closely related mycobacterial strains and species. The use of ISMY, and of proteins and peptides encoded by ISMY, in vaccines, pharmaceutical preparations and diagnostic test kits is also disclosed.  
         [0023]     WO0066157 patent application provides for polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides.  
         [0024]     U.S. Pat. No. 6,458,366 discloses compounds and methods for diagnosing tuberculosis. The compounds provided include polypeptides that contain at least one antigenic portion of one or more  M. tuberculosis  proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of  M. tuberculosis  infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.  
         [0025]     S. T. Cole has sequences the complete genome sequence of the best-characterized strain of  Mycobacterium tuberculosis,  H37Rv. The sequence has been analyzed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. [ Nature  393, 537-544 (1998)] 
         [0026]     In a multicomponent analysis to determine the association of polymorphism to the degree of virulence and infectivity is in progress. These polymorphisms constitute a set of putative virulence markers that are being validated in 120 clinical isolates of tuberculosis. The study results in a set of virulence markers, which could be used in predicting the degree of virulence and infectivity of Mycobacterium infections.  
         [0027]     There is no data or technical information in the prior art, which permits to select specifically potential new targets and protective antigens for new drugs and vaccine compositions to treat and prevent infectious diseases including mycobacterial diseases, particularly tuberculosis and leprosy.  
       SUMMARY OF THE INVENTION  
       [0028]     The object of the present invention is to identify genes which encode for essential proteins or regulatory nucleotidic sequences in the survival or infection of mycobacterium species as also all infectious diseases and which could be useful for the design of drugs and vaccines based on the knowledge of comparative genomics.  
         [0029]     Yet another object of the present invention is to provide for the identification of strains including mycobacterium in disease samples, for the specific recognition of pathogenic strains, for precisely distinguishing closely related strains including mycobacterial strains and for defining virulence and resistance patterns.  
         [0030]     The method according to the invention has the advantage to reduce drastically the number of potential new targets and protective antigens by giving for the first time an exhaustive description of conserved SNPs in different  M. tuberculosis  strains, which cause tuberculsosis. The isolated polynucleotides described in the present invention, which are highly conserved in genomic sequences of virulent strains are essential for the survival or the virulence of these strains, in particular mycobacteria, in the host. The identification of antigens and potentially therapeutic targets has been made by a method of comparative genomic analysis.  
         [0031]     The invention is directed to identifying virulence factors in  M. tuberculosis  &amp; other infectious diseases, using both strands of DNA, RNA and/or proteins associated with the virulence factors, allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence, infectivity and/or latency.  
         [0032]     Accordingly this invention provides a nucleotide sequences for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency of all infectious diseases having a SEQ ID nos 1 to 2531.  
         [0033]     The invention is further directed to a method comprising of aligning the genomic sequences of different mycobacteria species to  
         [0034]     a. Select a polynucleotide sequence highly conserved amongst the virulent strains and corresponds to an essential gene for the survival or the virulence of mycobacterium species  
         [0035]     b. Select polymorphisms between virulent and avirulent strains to identify genes and regions conferring virulence to the former strains  
         [0036]     c. And optionally, testing the polynucleotide selected for its capacity of virulence or involved in the survival of a mycobacterium species said testing being based on the activation or inactivation of said polynucleotide in a bacterial host or said testing being based on the activity of the product of expression of said polynucleotide in vivo or in vitro.  
         [0037]     The invention further comprises of identification of following polymorphisms, having potential to be used as reagents and in diagnostics, drug and vaccine development for infectious diseases:  
         [0038]     i. Identical nucleotide in. virulent strains/species, but a different nucleotide in avirulent strains/species at the same position  
         [0039]     ii. Some of the virulent strains differ in the nucleotide sequence at specific positions and share the nucleotide sequence with that of avirulent strains.  
         [0040]     Yet another object of the present invention is to provide for the identification of strains including mycobacterium in disease samples, for the specific recognition of pathogenic strains, for precisely distinguishing closely related strains including mycobacterial strains and for defining virulence and resistance patterns.  
         [0041]     The method according to the invention has the advantage to reduce drastically the number of potential new targets and protective antigens by giving for the first time an exhaustive description of conserved SNPs in different  M. tuberculosis  strains, which cause tuberculsosis. The isolated polynucleotides described in the present invention, which are highly conserved in genomic sequences of virulent strains are essential for the survival or the virulence of these strains, in particular mycobacteria, in the host. The identification of antigens and potentially therapeutic targets has been made by a method of comparative genomic analysis.  
         [0042]     The invention is directed to identifying virulence factors in  M. tuberculosis  &amp; other infectious diseases, using both strands of DNA, RNA and/or proteins associated with the virulence factors, allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence, infectivity and/or latency.  
         [0043]     Accordingly this invention provides a nucleotide sequences for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency of all infectious diseases having a SEQ ID nos 1 to 2531.  
         [0044]     The invention is further directed to a method comprising of aligning the genomic sequences of different mycobacteria species to  
         [0045]     a. Select a polynucleotide sequence highly conserved amongst the virulent strains and corresponds to an essential gene for the survival or the virulence of  mycobacterium  species  
         [0046]     b. Select polymorphisms between virulent and avirulent strains to identify genes and regions conferring virulence to the former strains  
         [0047]     c. And optionally, testing the polynucleotide selected for its capacity of virulence or involved in the survival of a mycobacterium species said testing being based on the activation or inactivation of said polynucleotide in a bacterial host or said testing being based on the activity of the product of expression of said polynucleotide in vivo or in vitro.  
         [0048]     The invention further comprises of identification of following polymorphisms, having potential to be used as reagents and in diagnostics, drug and vaccine development for infectious diseases:  
         [0049]     i. Identical nucleotide in virulent strains/species, but a different nucleotide in avirulent strains/species at the same position  
         [0050]     ii. Some of the virulent strains differ in the nucleotide sequence at specific positions and share the nucleotide sequence with that of avirulent strains.  
         [0051]     The invention relates to the identification and analysis of Non-synonymous SNPs to predict conservative and non-conservative amino acid substitutions. The effect of the substitution on the function of the proteins encoded provided a powerful insight in predicting SNPs correlating with virulence and infectivity in infectious diseases for example  M. tuberculosis.    
         [0052]     The invention further relates to proteins, RNA, DNA and metabolites encoded by the region carrying the polymorphisms in tuberculosis and other infectious disease causing organisms; which can be utilized for developing drugs and vaccines effective against tuberculosis and other infectious diseases, plays a important role in gene therapy, RNAi technology and imaging.  
         [0053]     The invention is also directed to a process for the production of recombinant polypeptides and chimeric polypeptides comprising them, antibodies generated against these polypeptides, immunogenic or vaccine compositions comprising at least one polypeptide useful as protective antigens or capable to induce a protective response in vivo or in vitro against mycobacterium infections, immunotherapeutic compositions comprising at least such a polypeptide according to the invention, and the use of such nucleic acids and polypeptides in diagnostic methods, vaccines, kits, or antimicrobial therapy.  
         [0054]     SEQ ID Nos. 1 to 1829 are single nucleotide polymorphisms.  
         [0055]     SEQ ID Nos. 1830 to 2286 is an insertion/deletion (indel)  
         [0056]     SEQ ID No 2287 to 2531 are regions of long polymorphism.  
         [0057]     The present invention also includes primer sequences for amplifying the region around the polymorphism SEQ ID nos 1 to 2531  
         [0058]     The nucleotide sequences flanking the polymorphisms of SEQ ID Nos. 1 to 2531 to a length of 35 nucleotides on either side are used in reagents and in diagnostics, drug development, RNAi, gene therapy and other such technologies.  
         [0059]     SEQ ID Nos 1 to 2531 are used as targets for drug design using bioinformatics and other tools, drug development, for gene therapy and vaccine development. This invention also includes the use of proteins, RNA, DNA and metabolites encoded by the region carrying the polymorphisms having a SEQ ID Nos. 1 to 2531 for RNAi technology and antisense technologies.  
         [0060]     This invention also includes a database for identification and selection of the polymorphisms having SEQ ID nos. 1 to 2531.  
     
    
     BRIEF DESCRIPTION OF THE FIGURES AND TABLES  
       [0061]      FIG. 1  describes Entity Relationship Model.  
         [0062]      FIG. 2  illustrates the identification of SNPs in  M. tuberculosis  strains H37Rv, CDC1551 and  M. bovis  BCG. A total of 1829 SNP&#39;s have been identified in the three genomes. Of these 1825 SNPs are identical in H37Rv and CDC1551, with a different nucleotide in BCG. 1579 of these are in ORFs while the rest (246) are in non-coding regions. The SNPs in the ORF are categorized into synonymous, non-synonymous SNPs. The latter are further categorized on the basis of the change in primary structure of the protein that results - conservative for no-change and non-servative for changed primary structure of protein encoded.  
         [0063]      FIG. 3  illustrates the identification of indels in  M. tuberculosis  strains H37Rv, CDC1551 and  M. bovis  BCG. A total of 794 indels have been identified in the three genomes. Of these, 237 are present in both H37Rv and CDC1551 with respect to BCG, 178 in ORF and 59 are outside the ORF.  
         [0064]      FIG. 4  illustrates Identification of long plymorphisms in  M. tuberculosis  strains H37Rv, CDC1551 and  M. bovis  BCG. 136 polymorphisms are present in the three genomes, 30 of them being identical to CDC1551 and H37Rv. 22 of these polymorphisms are present in the ORFs while 8 are outside the ORF.  
         [0065]      FIG. 5  display shows a region of 10 kb of the BCG genome with three types of annotations: BCG ORF&#39;s, SNP&#39;s in H37Rv, and SNP&#39;s in CDC1551.  
         [0066]      FIG. 6  shows the comparative genomics browser displaying BCG in the upper panel and H37Rv in the bottom panel. The segments labeled MUM-* are the perfect matches generated by the MUMmer tool, and the vertical lines show the alignment of the MUM segments in both genomes. The color coding of the ORF&#39;s is used to indicate the length of the ORF. This is very helpful to researchers because if an ORF in H37 aligns with an ORF in BCG but they have different colors, then there is a mutation that makes them have different lengths (see for example the genes in the MUTM-1280 region).  
         [0067]     FIG. 7.1-7.25 are the primers used for the amplification to encompass the regions of polymorphisms. 
     
    
       [0068]     Table 1 gives the list of Single Nucleotide Polymorphisms in  Mycobacterium tuberculosis/M. bovis  BCG.  
         [0069]     Table 2 gives the list of Insertions/deletions (Indels) in  Mycobacterium tuberculosis/M. bovis  BCG.  
         [0070]     Table 3 gives the list of long polymorphisms in  Mycobacterium tuberculosis/M. bovis  BCG.  
         [0071]     Table 4 lists Polymorphisms in genes involved in cell wall synthesis.  
         [0072]     Table 5 lists Polymorphisms in transcription factors.  
         [0073]     Table 6 lists Polymorphisms in genes involved in lipid metabolism  
         [0074]     Table 7 lists Polymorphisms in genes encoding membrane transport proteins  
         [0075]     Table 8 lists Polymorphisms in genes implicated in virulence  
       DETAILED DESCRIPTION OF THE INVENTION  
       [0076]     The  Mycobacterium tuberculosis  complex consists of six species— M. tuberculosis, M. bovis, M. caitotti, M. microtii  and  M. africanum.  Of these, the genomes of two different strains of  M. tuberculosis,  which are virulent and infective to humans, have been completely sequenced, while the complete genome of  M. bovis  BCG, which is non-virulent and non-infective has also been sequenced. Only partial sequences are available for the other species. All Mycobacterium sequences available in the NCBI, EMBL, GENBANK, Sanger and TIGR databases were retrieved and compiled.  
         [0077]     The total numbers of sequences retrieved are as follows:  
                                                                 Species name   No of sequences retrieved                                          Mycobacterium africanum     16             Mycobacterium canetti     03             Mycobacterium microtii     24             Mycobacterium tuberculosis     1274             Mycobacterium bovis     183                      
 
         [0078]     The complete genomes of  Mycobacterium tuberculosis  strains H37Rv (referred to as H37Rv) and CDC1551 (referred to as CDC1551) - both of which are virulent and infective to humans) and  Mycobacterium bovis  BCG (referred to as BCG)—non-virulent and non-infective in humans - were aligned and a database constructed. The structure of the database is given in  FIG. 1 .  
         [0079]     Sequences were aligned using the pairwise alignment tool “MUMmer-3.08” (www.tigr.org).  
         [0080]     The use of MUMmer required three distinct steps:  
         [0081]     1. running MUMmer for each of the target genomes (CDC1551 and H37Rv) against the reference genome (BCG)  
         [0082]     2. parsing the MUMmer output using to produce a list of polymorphisms, and loading these data into a polymorphism database.  
         [0083]     3. generating feature files for visualization, and loading these features into a feature database.  
         [0084]     BCG was chosen as the reference genome and compare the two tuberculosis strains, CDC1551 and H37Rv, against the reference. MUMmer uses fasta files as input and was run using the following command line:  
                                                                         run-mummer1 bovis.fasta cdc1551.fasta BCG-CDC           which takes the format,                program   &lt;reference&gt;   &lt;query&gt;   &lt;output&gt;                      
 
         [0085]     The BCG-CDC parameter provides the file name prefix for the output files, the bovis.fasta parameter is the reference fasta file, and the CDC1551.fasta parameter is the name of the query fasta sequence file.  
         [0086]     The database is generated using the scripts:  
         [0087]     Parsing MUMmer .align file to extract polymorphism data  
         [0088]     The file is parsed to extract useful information and stored it in a much simpler tab-delimited text file format. A custom perl script named mum-parse.pl which uses the Perl module Parse::RecDescent to create a recursive descent parser based on the grammar contained in the custom file Muinmer. pm. is used to run the following command line: 
 
$ perl./mum-parse.pl—mummer1—outfile=../mummer/BCG-CDC./mummer/BCG-CDC.align 
 
         [0089]     This creates three output files:  
         [0090]     1. BCG-CDC.gaps—this is the initial output file that simply lists the location of all exact matches in the two sequences.  
         [0091]     2. BCG-CDC.errorgaps—this is a processed version of the gaps file.  
         [0092]     3. BCG-CDC.align—this is the fully annotated file that is used to locate all polymorphisms.  
         [0093]     Pairwise alignments of BCG-H37Rv and BCG-CDC1551 was done using the BCG genomic sequence as reference. Results of the alignment identified three types of polymorphisms:  
         [0094]     1. SNPs—single nucleotide polymorphisms in one or more of the sequences aligned.  
         [0095]     2. indels—insertion or deletion of one or more bases in the sequences aligned.  
         [0096]     3. Long polymorphic regions—regions with numerous changes in the sequences aligned.  
         [0000]     Inserting the Annotation of the Complete Genomes into the Database  
         [0097]     The gene annotation downloaded from either genbank or EMBL is included into the database by running the following script 
 
$/work/mtb/scripts annot.pl—seq=[filename]—dbname=[NAME]—user=[NAME]—password=[PASS]
 
 filename indicates either genbank or the EMBL genes annotation file. 
 
 Inserting the Data into the DB 
 
         [0098]     To insert the CDC1551 SNP&#39;s into the DB the following command is run: 
 
$ perl/work/mtb/scripts/snp-insert.pl—snp=../mummer/BCG-CDC.snp—user=[NAME]—password=[PASS]—query_acc=NC — 002755 
 
         [0099]     To insert the H37Rv SNP&#39;s into the DB run the following command is run: 
 
$ perl/work/mtb/scripts/snp-insert.pl—snp=../mummer/BCG-H37.snp—user=[NAME]—password=[PASS]—query_acc=NC — 000962 
 
         [0100]     To determine whether SNP&#39;s are synonymous or non-synonymous, whether they are within or outside an open reading frame is first determined. All SNP&#39;s that lie within an ORF are taken and the amino acid for that codon containing the SNP is determined.  
         [0101]     To determine if the BCG locations lie within ORF&#39;s run the following command is run: 
 
$ perl/work/mtb/scripts/snp-orf-ref.pl—ref_seq=../seqs/bovis.fasta—user=[NAME]—password=[PASS]
 
         [0102]     All BCG locations within ORF&#39;s must have their amino acids determined. To do so, the following command is run: 
 
$ perl/work/mtb/scripts/ref-aa.pl—ref_seq=../seqs/bovis.fasta—user=[NAME]—password=[PASS]
 
         [0103]     Next, the H37Rv and CDC1551 locations are mapped. To assign the CDC1551 ORF&#39;s the following command is run: 
 
$ perl/work/mtb/scripts/snp-orf2.pl—query_seq=../seqs/CDC1551.fasta—user=[NAME]—password=[PASS]
 
         [0104]     To assign the H37Rv ORF&#39;s the following command is run: 
 
$ perl scripts/snp-orf2.pl—query_seq=../seqs/H37Rv.fasta—user=[NAME]—password=[PASS]
 
         [0105]     To determine whether the CDC1551 SNP&#39;s are synonymous or non-synonymous the following command is run: 
 
$ cd/work/mtb/scripts 
 
$ perl s/work/mtb/scripts/synomous.pl—bcg_file=../seqs/bovis.fasta—query_seq=../seqs/CDC1551.fasta—user=[NAME]—password=[PASS]
 
         [0106]     To determine whether the H37Rv SNP&#39;s are synonymous or non-synonymous the following command is run: 
 
$ cd /work/mtb/scripts 
 
$ perl/work/mtb/scripts/synomous.pl—bcg_file=../seqs/bovis.fasta—bcg_file=../seqs/H37Rv.fasta—user=[NAME]—password=[PASS]
 
         [0107]     A set of summary columns are used to coallesce all the SNP data in one place. To do this, the following command is run: 
 
$ perl/work/mtb/scripts/compare-snps.pl—user=[NAME]—password=[PASS]
 
         [0108]     To insert data into the SNP analysis table the SNP data from the SNP, SEQ_SNP and gene ontology tables is fetched and entered into the SNP_analysis table. This step also identifies the conservative and non-conservative amino acids.  
         [0109]     To do this, the following program is run: 
 
$ run.sh/work/mtb/scripts/ 
 
         [0110]     The SNP data in the database is thus complete.  
         [0000]     Analysis of SNPs  
         [0111]     The SNPs identified were of two kinds:  
         [0112]     i. Identical nucleotide in CDC1551 and H37Rv, but a different nucleotide in BCG at the same position.  
         [0113]     ii. One of the three sequences is polymorphic; the nucleotide sequence of CDC1551 and H37Rv are different from each other and one of them is identical to the BCG sequence at identical positions.  
         [0114]     The SNPs thus identified were categorized according to their location in Open Reading Frames. SNPs falling within the ORF of both BCG and H37Rv were identified. The results were validated by determining if the SNPs were present in the ORFs of BCG and CDC1551.  
         [0115]     The SNPs falling in ORFs were further categorized into synonymous and non-synonymous SNPs. A SNP was said to cause a non-synonymous change if:  
         [0116]     1) It occurs in an ORF  
         [0117]     2) It occurs in the *same* ORF in the genome it is being compared to.  
         [0118]     In some cases a SNP can be in one ORF in the reference sequence but in another ORF in the comparison sequence, e.g. due to a frame-shift mutation earlier in the sequence.  
         [0119]     So before we assign SNP&#39;s to ‘Non Synonymous’ or ‘synonymous’ groupings all SNP&#39;s which either did not fall in an ORF, or fell into different ORF&#39;s on the reference and comparison sequences were eliminated. The BCG and H37 genomes have been annotated with respect to one another. However CDC1551 has not been so thoroughly annotated, so it was not possible to immediately assess if an ORF in BCG was the corresponding ORF in CDC. Therefore, a metric was devised to eliminate spurious comparisons.  
         [0120]     The non-synonymous SNPs thus identified was analysed to predict conservative and non-conservative amino acid substitutions. The effect of the substitution on the function of the proteins encoded was predicted. This provides a powerful insight in predicting SNPs correlating with virulence and infectivity in  M.tuberculosis.    
         [0121]     Below is an example of the output obtained from the database. 
         
 
         [0122]     The above figure describes the SNP details, which is as follows:  
         [0123]     Bovis_pos—Bovis position having a SNP.  
         [0124]     Bovis_ORF—Y es indicates that the SNP in bovis is in bovis ORF. No indicates not in ORF.  
         [0125]     Bovis_base—Indicates the SNP detailSNP pos ition in bovis  
         [0126]     Bovis_AA—Displays the bovis amino acid after the codon translation.  
         [0127]     Qry_name—Displays the name of a strain, example H37Rv or microtii  
         [0128]     Qry_pos—Displays the position of a SNP in either CDC1551 or H37Rv with respect to bovis SNP position.  
         [0129]     Qry_ORF—Displays Yes if the SNP falls in the ORF of the query (H37Rv or CDC1551)  
         [0130]     Qry_base—Displays the query SNP.  
         [0131]     Qry_AA—Displays the amino acid of the query (H37Rv or CDC1551).  
         [0132]     Is_nsSNP—Displays SNPs synonymous (S), non-synonymous (NS) and SNPs in non-coding region (NC).  
         [0133]     Conservative_subst—Displays homologous substitution in H37rv and CDC1551.  
         [0134]     Fun_annotation—Will display the functional annotation of the query.  
         [0135]     A list of Single nucleotide polymorphisms identified in the manner described above is given in Table 1.  
         [0136]     A total of 1829 have been identified in the three genomes. Of these 1825 SNPs consist of having the same nucleotide in H37Rv and CDC1551, with a different nucleotide in BCG. Of thel829 SNPs, 1579 are in ORFs while the rest (246) are in non-coding regions. 811 H37Rv SNPs and 810 CDC1551 SNPs are synonymous while 1282 H37Rv and 1219 CDC1551 SNPs are non-synonymous. Out of 1219 CDC1551 nsSNPs, 312 SNPs have conservative amino acid substitution, 888 have non-conservative substitution and 19 results in truncated proteins. Out of 1282 H37Rv non-synomous SNPs, 304 have conservative amino acid substitution, 954 have non-conservative substitution and 24 results in truncated proteins. ( FIG. 2 )  
         [0000]     Analysis of Indels (Insertions and Deletions):  
         [0137]     Indels are insertions and deletions in the sequence with respect to BCG sequence. These indels could be of one or more nucleotides. Considering BCG as reference sequence, the indels in the both the strains of M.tuberculosis, H37rv and CDC1551 were identified.  
         [0138]     To insert the indels from the align file of the mummer output into the database, the following java program is run: 
 
$ java/work/mtb/scripts/indel 
 
         [0139]     To enter functional annotation from the gene ontology database into the indels table, the following program is run: 
 
$ java/work/mtb/scripts/indfunction 
 
         [0140]     The list of indels identified is given in Table 2.  
         [0141]     A total of 794 indels have been identified in the three genomes. Of these, 237 (H37Rv) and 237 (CDC1551) indels are present in both H37Rv and CDC1551 with respect to BCG. Of these, 178 are in ORF and 59 are outside the ORF. ( FIG. 2 )  
         [0000]     Analysis of Long polymorphs:  
         [0142]     Long polymorphs are insertions or deletions of long stretches of nucleotides with respect to BCG sequence.  
         [0143]     To insert the long polymorphs from the align file of the mummer output into the database, following java program is run: 
 
$ java/work/mtb/scripts/indel 
 
         [0144]     To enter the functional annotation from the gene ontology database into the long polymorph table, following java program is run: 
 
$ java/work/mtb/scripts/indfunction 
 
         [0145]     A table listing the long polymorphisms is given in Table 3.  
         [0146]     A total of 136 long polymorphisms have been identified in the three genomes. Of these, 30 (H37Rv) and 30 (CDC1551) indels are present in both H37Rv and CDC1551 with respect to BCG. Of these, 22 are in ORF and 8 are outside the ORF. ( FIG. 3 )  
         [0000]     Functional Annotation of the Polymorphisms Identified  
         [0147]     In order to identify polymorphisms with a putative functional association, a tool was built using the Gene Ontology DB (GO). The EMBL sequence DB has made putative GO assignments to most of the ORF&#39;s in the three TB genomes, so a local installation of GO was used together with the EMBL cross reference tables to identify TB polymorphisms based on their putative functional classification.  
         [0148]     The annotation table consisting of the genbank features of the genes such as coding region, database reference and product information to name a few was constructed.  
         [0149]     To inserts the gene ontology features such as term definition and name from the gene ontology database into the indels and long polymorph table, following program is run: 
 
$ java/work/mtb/scripts/indfunctionl 
 
         [0150]     The following are the list of attributes in the annotation table.  
         [0151]     Accession no—This indicates the accession number of the sequences  
         [0152]     Gene_start—This indicates the start of the coding region  
         [0153]     Gene_end—This indicates the end of the coding region  
         [0154]     Locus_tag— 
         [0155]     db_xref—This indicates the gene indices representation of the gene  
         [0156]     db_xref_GOA—This indicates the gene ontology identity of the gene product  
         [0157]     id—This indicates the gene annotation  
         [0158]     type— 
         [0159]     strand—This indicates the forward or reverse strand of the sequence that is stored in the genbank  
         [0160]     gene_name—This indicates the gene name  
         [0161]     gene_link—This provides a hyperlink to the gene features form the genbank  
         [0162]     note—This provides the general information and the protein information of the gene.  
         [0163]     A front-end was constructed as an essential part of the database:  
         [0000]     Front End of the Database:  
         [0164]     The front-end displaying the results of alignment as follows:  
         [0165]     The annotation table consists of genbank annotation about the genes in bovis, H37Rv and CDC1551. It specifies details including the coding region of a gene and its database reference.  
         [0166]     The annotation id for the SNPs, indels and long polymorphs has been hyperlinked to obtain all the records pertaining to a particular gene.  
         [0167]     The data pertaining to indels and long polymorphs have also been added to the front-end.  
         [0000]     Description of the Queries:  
         [0168]     The database is made queryable to retrieve the required features of SNPs, indels and long polymorphs respectively.  
         [0169]     The main options to query the SNP information are:  
         [0000]     Select SNPs  
         [0170]     ALL—This displays all the records which satisfies the below features.  
         [0171]     Identical in both queries—This query indicates that SNPs are present in BCG with respect to H37Rv and CDC1551.  
         [0172]     Different bases in both queries—This query indicates different nucleotides in H37Rv and CDC1551.  
         [0173]     Having SNPs in BCG-H37 only—This query specifies SNPs in BCG and H37Rv only and not in CDC1551.  
         [0174]     Having SNPs in BCG-CDC only—This query specifies SNPS in BCG and CDC1551 only and not in H37Rv.  
         [0175]     BCG-H37 SNPs—This query indicates, that SNPs are present in H37Rv with respect to BCG-position and may or may not be present in CDC1551 at that particular position.  
         [0176]     BCG-CDC SNPs—This query indicates, that SNPs are present in CDC1551 with respect to BCG position and may or may not be present in H37Rv at that particular position.  
         [0177]     The other options considered are:  
         [0178]     Select BCG ORF—This provides an option to select the presence of BCG SNPs in BCG ORF or outside the BCG ORF.  
         [0179]     Select query ORF—This provides an option to select the presence of query SNPs in query ORF or outside the query ORF.  
         [0180]     Select synonymous—This provides an option to select if the SNP is synonymous or non-synonymous.  
         [0181]     Select Conservative—This provides an option to select if the non-synonymous SNP results in conservative, non-conservative substitution or truncated protein.  
         [0182]     Select function—This provides an option to select a required function, which includes cell wall synthesis, Transcription factor, Lipid metabolism, Membrane transport and Surface proteins.  
         [0183]     An example of a query to extract SNP information from the database is shown below. 
         
 
         [0184]     The result obtained from the above query is shown below: 
         
 
         [0185]     The query has been designed in the similar way for both indels and long polymorphs.  
         [0186]     The SNP analysis includes functional annotation id, which is hyperlinked to the functional annotation of the gene carrying the polymorphism. The functional annotation id consists of either one of the Swiss Prot, SPTREMBL or gene ontology id&#39;s. Similarly the indels and long polymorphs are also functionally annotated.  
         [0187]     Genes with known involvement in virulence of Mycobacterium tuberculosis can also be accessed from the SNP database query or from the Long polymorphs database query respectively.  
         [0188]     Polymorphisms involved in the following functions have been identified:  
         [0189]     1. Cell wall synthesis  
         [0190]     2. Transcription factor  
         [0191]     3. Lipid metabolism  
         [0192]     4. Membrane transport  
         [0193]     5. Surface proteins.  
         [0194]     6. Virulence genes  
         [0195]     One such query for cell wall synthesis function is shown below 
         
 
         [0196]     The output of the above query is shown below 
         
 
         [0197]     The polymorphisms detected in genes involved in cell wall synthesis are listed in Table 4.  
         [0000]     Visualization Tools  
         [0198]     To increase the utility of the SNP data, two tools to visualize the Tuberculosis SNP data have been created: the first tool was based on the Generic Genome Browser developed at Cold Spring Harbor Lab (CSHL). This visualization tool could show a single TB genome along with any annotations, e.g. SNP locations for all other genomes.  
         [0199]     The details of the browser is as follows:  
         [0200]     The output displays the polymorphs in the region of interest.  
         [0201]     Alternatively the output can be obtained by specifying the region of interest in the text box labeled as “landmark or region”. In case of SNP, the gene start and the gene end has to be specified and in case of indels or long polymorphs, the BCG start and BCG end must be specified.  
         [0202]     By clicking the ruler at the region of interest across the genome, the view can be re-centered.  
         [0203]     The display can also be zoomed in or out by selecting the required number of base pairs in the scroll down menu.  
         [0204]     The required features can be displayed by selecting the options in the tracks checkbox as shown in  FIG. 4   
         [0205]      FIG. 4  display shows a region of 10 kb of the BCG genome with three types of annotations: BCG ORF&#39;s, SNP&#39;s in H37Rv, and SNP&#39;s in CDC1551.  
         [0206]     To compare multiple genomes, a second tool based on the WormBase synteny browser was built. This tool can visualize two TB genomes at one time and was very useful in validating the polymorphisms the CDC1551 genome as shown in  FIG. 5 .  
         [0207]      FIG. 5  shows the comparative genomics browser displaying BCG in the upper panel and H37Rv in the bottom panel. The segments labeled MUM-* are the perfect matches generated by the MUMmer tool, and the vertical lines show the alignment of the MUM segments in both genomes. The color coding of the ORF&#39;s is used to indicate the length of the ORF. This is very helpful to researchers because if an ORF in H37 aligns with an ORF in BCG but they have different colors, then there is a mutation that makes them have different lengths (see for example the genes in the MUM-1280 region).  
         [0208]     A methodical screening of all the regions of polymorphism identified above in clinical isolates with known disease profiles to further home-in on the polymorphisms associated with virulence and/or infectivity in  M.tuberculosis  is in progress.  
         [0000]     2. Screening of Regions of Polymorphisms  
         [0209]     A set of five  Mycobacterium tuberculosis  strains with known virulence is being screened for the polymorphisms identified above.  
         [0210]     Strains chosen: The following strains have been chosen for the study:  
         [0211]     a. H37Rv—a reference laboratory strain known to be infective to mice, but is only mildly infective in humans. It has undergone a number of passages in the lab since its isolation. It is the standard used in studies on tuberculosis in different laboratories across the world.  
         [0212]     b. Beijing strain—a clinical isolate with known virulence and infectivity in humans. 70% of the patients with tuberculosis in certain areas of India and China are infected with this strain. The strain was isolated from a patient in the Western Indian state of Mumbai.  
         [0213]     c. S.I—a mild South Indian strain with only mild virulence and infectivity in humans isolated from a patient residing in the South Indian state of Hyderabad.  
         [0214]     d. N.I.F—Fatal North Indian strain isolated from Safderjung hospital, Delhi where the patient developed pulmonary tuberculosis died.  
         [0215]     e. N.I.NF—a non-fatal North Indian strain isolated from Safderjung hospital, Delhi. Known clinical progression of disease in the patient.  
         [0216]     Primers have been designed to encompass the regions of polymorphisms. The list of the primers used for the amplification is given in the  FIG. 6 . 1 - 6 . 25   
         [0217]     Amplification and sequencing of regions around the polymorphisms: DNA from the five strains has been amplified under optimal conditions determined for each primer pair. The amplified fragments have been sequenced and the sequences obtained from different strains compared.  
         [0218]     A few examples are given below:  
                                                 60       70        80        90       100       110               +---------+---------+---------+---------+---------+-----       BCG   ACCGATCTCGCCGCGCAGACAATGGCTGGCTCAGCGGCGATGCTGCTGGAGCGGAT               H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CD1551   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++                          120       130       140       150       160       170               ----+---------+---------+---------+---------+---------+       BCG   GGACCAAGACCAGGGTGGCGCCAATGGCGAGCTGATGGGGCTGCGCGTGGACCTT               H37Rv   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++               CD1551   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0219]     Sequencing of the region from 1H-590622 to H-591026. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M. tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; NINF: non-lethal North Indian strain; BS: Beijing strain; NIF: Lethal North Indian strain. The gene coding for oxidoreductase activity is a virulence gene which does not show any differences between the  M.tuberculosis  strains, but has a conservative polymorphism with  M.bovis  BCG.  
                                   130      140       150       160       170       180       190       200       210               +--------+---------+---------+---------+---------+---------+---------+---------+       BCG   CCAGGCCTCGATCGACGATCTGGCGTCTCTCGAAGAAGACTTTACCGTTGCACGTCGCCGTCTACCGGCGGGTGATTGCGG               H37Rv   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++               NIF   +++++++++++++++++++++++++++++++++++++++++++-+++++++++++++++++++++++++++++++++++++          
 
         [0220]     Sequencing of the region from 11-138548 to 11-139067. Sequences are amplified from different strains. BCG:  M.bovis BCG; H 37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF: Lethal North Indian strain The insertion in BCG leads to a shorter protein with a different carboxyl terminal compared to the transcription factor encoded by the tuberculosis strains.  
                                                                                                                     10       20        30        40        50        60        70               +---------+---------+---------+---------+---------+-----+---       BCG   GTGGCGAGCCGGCAAACCCCTGCTGAGCTGGCCAGATGCGACTTGGCTAAGACCGCGGAGCGCG               CDC1551   +++++++++++++++A++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++++++++A++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++-++++++++++++++++++++++++++++++++++++++++++++++++               NTNF   +++++++++++++++-++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++-++++++++++++++++++++++++++++++++++++++++++++++++                                 80        90       100       110       120       130                   ------+---------+---------+---------+---------+---------|           BCG   AGCACACCCCGACGGCGACTGCGACAACTCCAAGCGTGGCCGGTAACGTGATGCCCA                       H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       NTNF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                            131    140       150       160       170       180       190               |--------+---------+---------+---------+---------+---------+---       BCG   TGATTGTGCGTTCCCTTCCCGCTGCGTTGCGCGCGTGTGCGCGTCTGCAACCCCATGACCCGG               CDC1551   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NTNF   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++G+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                                200       210       220       230       240       250                   ------+---------+---------+---------+---------+---------+           BCG   CCTTCACGTTTATGGATTACGAACAGGACTGGGACGGCGTTGCGATAACCCTGACGT                       CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       NTNF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                       SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++                            251     260       270       280       290       300       310               |---------|---------+--------- +---------+---------+---------+--       BCG   GGTCGCAGCTGTATCGGCGAACGCTGAATGTGGCACGGGAGCTGAGCCGTTGTGGTTCCAGGT               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C+G               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C+G               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C+G               NTNF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C+G               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C+G                                 320       330       340       350       360       370                   -------+---------+---------+---------+---------+---------+           BCG   CGCAGCTGTATCGGCGAACGCTGAATG--TGGCACGGGAGCTGAGCCGTTGTGGTTC                       CDC1551   -+TGA+C+CG+-++T++T+T+++CTCCGCA++G++TC+++-+AC+T+++C+CCT+++                       H37Rv   -+TGA+C+CG+-++T++T+T+++CTCCGCA++G++TC+++-+AC+T+++C+CCT+++                       BS   -+TGA+C+CG+-++T++T+T+++CTCCGCA++G++TC+++-+AC+T+++C+CCT+++                       NTNF   -+TGA+C+CG+-++T++T+T+++CTCCGCA++G++TC+++-+AC+T+++C+CCT+++                       SI   -+TGA+C+CG+-++T++T+T+++CTCCGCA++G++TC+++-+AC+T+++C+CCT+++          
 
         [0221]     Sequencing of the region from H-3283171 to H-3283585. Two SNPs, one indel and a long polymorphism characterize this region. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I South Indian strain A2313; BS: Beijing strain; NIF: non-lethal North Indian strain. All the polymorphisms occur in the fadD28, a virulence gene involved in fatty acid synthesis. They result in a non-conservative substitution and probably have an important role in the degree of virulence imparted to the strain.  
                                                                                                             130     140       150       160       170       180       190       200       210               +---------+---------+---------+---------+---------+---------+---------+---------+            BCG   TTGGCCCACGTGCTGAACTTGGTGACGTTGGCTGCGGTGACAAACAAGTTCTGATAGGTCGTTGCGCCCGTCGGCCCGAAG                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++C+++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++C+++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++A+++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++A+++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++A+++++++++++++++++++++++++++++++++                        211     230       240       250       260       270       280       290                ---------+---------+---------+---------+---------+---------+---------+---------            BCG   ATGAGTTGGCCCATGAGTTGGGTGTATTGGGTGCTGAGTGTGGCCAGGCCCTGCAGCAGGGTCGGGATGATGTCGAACG                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        300      310      320       330       340       350       360       370       380               +---------+---------+---------+---------+---------+---------+---------+---------+            BCG   GAAACTGCGCCGCTGCACTCGAAAGCGCGGTTGTCACCGCATTGGTGCCGCTCGCTAGGGCGGTCGCTTSCCCCGTTGCGG                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++++++++          
 
         [0222]     Sequencing of the region from H-2051784 to H-2052209. This region is characterized by a SNP between  M.bovis  BCG and the tuberculosis strains and a second SNP common to the Asian strains and to BCG, but different from H37Rv and CDC1551. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. The SNP common to all the tuberculosis strains results in a conservative substitution in the PPE33b gene and does not affect the function of this gene. However the A to G substitution results in the truncation of the protein encoded by BCG.  
                                                                                 150     160       170       180       190       200       210       220       230       240                +---------+---------+---------+---------+---------+---------+---------+---------+---------+            BCG   CATCGTCGCCGGCGCGGGTCACTGGCGCCGCTCCTCCCCATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCACTGGCGCCGCTCCTCCC                   H37Rv   +++++++++++++++++++++----------------------------------------------------------------------               CDC1551   +++++++++++++++++++++----------------------------------------------------------------------               SI   +++++++++++++++++++++CTGGCGCCGCTCCTCCCCATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCACTGGCGCCGCTCCTCCC               BS   +++++++++++++++++++++CTGGCGCCGCTCCTCCCCATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCACTGGCGCCGCTCCTCCC               NINF   +++++++++++++++++++++CTGGCGCCGCTCCTCCCCATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCACTGGCGCCGCTCCTCCC                        241       250       260       270       280       290       300               +---------+---------+---------+---------+---------+---------+            BCG   CATCGCTTTGCTCTCTGCATCGTCGCCGGCGCGGGTCAATCGAAGATGCCCCGTCGCGTGTC                   H37Rv   ------------------------------------++++++++++++++++++A+++++               CDC1551   ------------------------------------++++++++++++++++++H+++++               SI   CATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCA++++++++++++++++++A+++++               BS   CATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCA++++++++++++++++++A+++++               NINF   CATCGCTTTGCTCTGCATCGTCGCCGGCGCGGGTCA++++++++++++++++++A+++++          
 
         [0223]     Sequencing of the region from H-3006917 to H-3007246. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; M18: non-lethal North Indian strain. This region encloses a long polymorphism of 106bp inserted into a gene encoding an integral membrane protein in BCG and the Asian strains. This results in a longer integral membrane product in these strains as compared to H37Rv and CDC1551. The SNP also results in the introduction of a stop codon in H37Rv and CDC1551 further reducing the length of the membrane protein encoded by the latter.  
                                                                                                                                         40       50        60        70        80        90       100       110       120               +---------+---------+---------+---------+---------+---------+---------+---------+            BCG   CTGGGTCAGCAGCGGGTGTGCGCTGATTTCGATGAAGGTGTGGTAGGCGCCGTCGGCGCCGCTACCGGCGGAAGCGATGGC                   BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++C+++++++++++++++++++++++++++++++++++++++++++++++++++++                        121     130       140       150       160       170       180       190       200                ---------+---------+---------+---------+---------+---------+---------+---------+            BCG   CTGGCTGGAAATGCACGGGGTTGCGCATGTTGGTGGCCCAGTGTTCGGCGTCGAAGACCGGTTGGGTGTGCAAGTCTGCGT                   BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++GC++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        201     210       220       230       240       250       260       270       280               ---------+---------+---------+---------+---------+---------+---------+---------+            BCG   AGGTGGTGGAGATGATTCCGATGGTGGGGGTCCGTGGGGTCAGATCGGCCAGCTCCGAACGCATCGCCGGCTGCAAAGCA                   BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        281    281       300       310       320       330       340       350       360               ---------+---------+---------+---------+---------+---------+---------+---------+            BCG   TCCATGGCCGGATTGTGCGGGGCCACTTCGATATTGACCCGGCTGGCGAATCGGTCCCTAGCGCGCACGCGAGTGATCAA                   BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++A+++++A++C+++TTTGC++++++++C++G+C++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++A+++++A++C+++TTTGC++++++++C++G+C++++++          
 
         [0224]     Sequencing of the region from H-3247737 to H-3248224 Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. All the polymorphisms observed occur in ppsA—the polyketide synthase gene and are synonymous substitutions. All the three Asian strains show identity to BCG in this region.  
                                                                                 100      110       120       130       140       150       160                +---------+---------+---------+---------+---------+---------+-----            BCG   CGCGGTACACGTGTCGAACGGCGACAAACCCAAGGTTGCCTTGCCCGATACTCAGTTGGGTTCACA                   H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                          170       180       190       200       210       220       230               ----+---------+---------+---------+---------+---------+---------+            BCG   CTCAACGTGATTCGAAATCCACACTGATACTGGAGGTGATTACCGGCTGAAGCAAAGCGCATTGG                   H37Rv   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   ++G++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0225]     Sequencing of the region from H-2052524 to H-2052863. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; N1NF: non-lethal North Indian strain; NIF: Lethal North Indian strain .A single nucleotide polymorphism occurring in the proton transport gene PPF,33b results in the introduction of a stop codon and hence truncation of the protein in BCG.  
                                                     190      200       210       220       230       240                +---------+---------+---------+---------+---------+---------       BCG   CATCGGCCGAAACGTGAGTAATCTGGGCGGCC----------------------------               CDC1551   ++++++++++++++++++++++++++++++++CGCTCAGCGCCCAGGGCATCGAAGAACA               H37Rv   ++++++++++++++++++++++++++++++++CGCTCAGCGCCCAGGGCATCGAAGAACA               BS   ++++++++++++++++++++++++++++++++CGCTCAGCGCCCAGGGCATCGAAGAACA               NINF   ++++++++++++++++++++++++++++++++CGCTCAGCGCCCAGGGCATCGAAGAACA               SI   ++++++++++++++++++++++++++++++++CGCTCAGCGCCCAGGGCATCGAAGAACA                            250       260       270       280       290                     +---------+---------+---------+---------+           BCG   -------------------GTGGCTCGGGGCGGCCCACACC                           CDC1551   AGCCCAGGGTGGCCTTGTC+++++C++++++++++++++++                       H37Rv   AGCCCAGGGTGGCCTTGTC+++++C++++++++++++++++                       BS   AGCCCAGGGTGGCCTTGTC+++++C++++++++++++++++                       NINF   AGCCCAGGGTGGCCTTGTC+++++C++++++++++++++++                       SI   AGCCCAGGGTGGCCTTGTC+++++C++++++++++++++++          
 
         [0226]     Sequencing of the region from H-1468644 to H-1469150. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551;S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. An insertion of 47bp is seen in all the tuberculosis strains in Mbl346c, a gene with DNA binding activity. A second polymorphism (SNP) is also seen immediately adjacent to the insertion in the same gene. The SNP results in splitting the gene into two genes while there is a single long gene in the  M.tuberculosis  strains.  
                                                                                     190     200       210       220       230       240               +---------+---------+---------+---------+---------+----            BCG   TGTTGGCTTCATCAGCACCCCGAGGTGTGTATTCAGGCGATCCGGGGCAGCG                   CDC1551   ++++++++++++++++++++++++++++--++++++++++++++++C+++T++++               H37Rv   ++++++++++++++++++++++++++++--++++++++++++++++C+++T++++               NINF   ++++++++++++++++++++++++++++--++++++++++++++++C+++T++++               SI   ++++++++++++++++++++++++++++--++++++++++++++++C+++T++++               BS   ++++++++++++++++++++++++++++--++++++++++++++++C+++T++++                           250       260       270       280       290               -----+---------+---------+---------+---------+                BCG   GGGTCGGGGTGACGCGGTTCCGCCCAAAGGTCC--GTCACCCTGTG                           CDC1551   +++++++++++++++++++++++++++++++++AC+++++++++++                       H37Rv   +++++++++++++++++++++++++++++++++AC+++++++++++                       NINF   +++++++++++++++++++++++++++++++++AC+++++++++++                       SI   +++++++++++++++++++++++++++++++++AC+++++++++++                       BS   +++++++++++++++++++++++++++++++++AC+++++++++++          
 
         [0227]     Sequencing of the region from H-455094 to H-455468. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. The region is characterized by the occurrence of two indels and two SNPs in a transcription regulator. All the tuberculosis strains appear to be identical in this region while BCG, has a different amino-acid sequence in the region.  
                                                     60       70        80        90       100       110       120               +---------+---------+---------+---------+---------+---------+       BCG   CAGATCGGCTCGGTCCGCTTCGCGATTTACCGCTCGGACTATGTGCAGTCGGTGACGGCTC                   CDC1551   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++               H37Rv   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++               NTNF   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++                                   130       140       150       160                   ---------+---------+---------+---------|           BCG   ++++++++++++++++++++++++++++++A+++++++++                           CDC1551   ++++++++++++++++++++++++++++++A+++++++++                       H37Rv   ++++++++++++++++++++++++++++++A+++++++++                       BS   ++++++++++++++++++++++++++++++A+++++++++                       NTNF   ++++++++++++++++++++++++++++++A+++++++++                       SI   ++++++++++++++++++++++++++++++A+++++++++                       NIF   ++++++++++++++++++++++++++++++A+++++++++          
 
         [0228]     Sequencing of the region from H-466229 to H-466536. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M. tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF: Lethal North Indian strain .The C to T transition occurs in a gene of unknown function and results in a synonymous substitution. However, the C to A change occurs in a transcription factor (Mb0393) and is a non-conservative substitution resulting in a slightly different protein in BCG.  
                                                     130     140       150       160       170       180       190       200               +---------+---------+---------+---------+---------+---------+---------+            BCG   CCGCCAGGGTTACACCGACGTCGACCAGTTCACACTCGAAAAGTAACCGGACAAAGCGCGCTGGCTACCCA                   CDC1551   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++               H37Rv   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++G++++++++++++++++++++++++++++++++++          
 
         [0229]     Sequencing of the region from H-560625 to H-561248. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF: Lethal North Indian strain. A synonymous SNP occurs in a virulence gene and is identical in all the tuberculosis strains.  
                                                                                     150       160       170       180       190       200               --+---------+---------+---------+---------+---------+            BCG   GGCCCACGATTTGCAATGGTGACGAGTTGGCTGCCTCGGCGCTGGCGTACTAG                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++G+               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++G+               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++G+               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++G+               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++G+               NIF   +++++++++++++++++++++++++++++++++++++++++++++++++++G+                               210       220       230       240       250               ---------+---------+---------+---------+---------+                BCG   GCCGCCCCCGCGCTCATGAGCTGGACGAACTGCTCATGGAATGCGACCGC                           H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++                       CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++                       BS   +++++++++++++++++++++++++++++++++++++++++++++++++                       SI   +++++++++++++++++++++++++++++++++++++++++++++++++                       NINF   +++++++++++++++++++++++++++++++++++++++++++++++++                       NIF   +++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0230]     Sequencing of the region from H-2046394 to H-2046928. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF: Lethal North Indian strain. The SNP in BCG results in splitting the gene PE-PGRS32 into two parts with the latter being truncated.  
                                                                                                                                             40       50        60        70        80        90               +---------+---------+---------+---------+---------+-----            BCG   ACGATCATCGGTGGTGGTGGAGCCGGTATGGTAGCTACCGCCACGCGGAAGCTGGT                   CDC1551   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++               H37Rv   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++A+++++++++++++++++++++++++++++                          100       110       120       130       140       150                      ----+---------+---------+---------+---------+---------+            BCG   CGGCGGGCGCTTCATGGCGATGACGACCGGACCGGACAGGTCTATGCCGGACGCG                   CDC1551   ++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++                        151    160       170       180       190       200               +--------+--------+---------+---------+---------+------            BCG   GCGACCGCGGCCACCGGGGTGATAACGGCGTGCACCGGCGCGGTTCTCCCGGGGAA                   CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++                         210       220       230       240       250       260               ---+---------+---------+---------+---------+---------+                BCG   TACCGGAGCCGCGCCGCCGACCGCACTGGCGAATACCAACGGGGCAATCGCTGC                           CDC1551   ++++++++++++++C++++++++++++++++++++++++++++++++++++++                       H37Rv   ++++++++++++++T++++++++++++++++++++++++++++++++++++++                       NINF   ++++++++++++++C++++++++++++++++++++++++++++++++++++++                       SI   ++++++++++++++C++++++++++++++++++++++++++++++++++++++                       BS   ++++++++++++++C++++++++++++++++++++++++++++++++++++++                       NIF   ++++++++++++++C++++++++++++++++++++++++++++++++++++++          
 
         [0231]     Sequencing of the region from 11-1373629 to 11-1374101. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M. tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF: Lethal North Indian strain. The two polymorphisms observed occur in a transcription factor and result in non-conservative substitutions.  
                                                                                 220     230       240       250       260       270       280               +---------+---------+---------+---------+---------+---------+            BCG   TCTCTCGGTCATTCGTGGTCGCAGGCGCCGCACTCGGTGTCTTCGGGGGGGGGGGGGGGGG                   H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------               CDC1551   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------               SI   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------               BS   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------               NINF   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------               NIF   ++++++++++++++++++++++++++++++++++++++++++++++T++++---------                               290       300       310       320       330       340               ---------+---------+---------+---------+---------+---------+            BCG   GGGGGGGGGGGAAGCGCGACCTCGAAGGCCACTGAAACGCCTTACGGAGACGCGACGAAC                   H37Rv   -----------++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   -----------++++++++++++++++++++++++++++++++++++++++++++++++               SI   -----------++++++++++++++++++++++++++++++++++++++++++++++++               BS   -----------++++++++++++++++++++++++++++++++++++++++++++++++               NINF   -----------++++++++++++++++++++++++++++++++++++++++++++++++               NIF   -----------++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0232]     Sequencing of the region from H-1622821 to H-1623282. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF:North Indian Fatal. The polymorphisms observed occur in a non-coding region outside the ORF.  
                                                     150     160       170       180       190       200       210       220       230               +---------+---------+---------+---------+---------+---------+---------+---------+            BCG   TGTGGCGCGCCTGGCTCAGATAACGCAACGCCGCAGGCGCGCGCCGCACGTCAAAAGTGGTGACCGGCAACGGCCGCAGCA                   CDC1551   ++++++++++++++++++++++++++++++++++++++++++A++++++++++++++++++++++++++++++++++++++               H37Rv   ++++++++++++++++++++++++++++++++++++++++++A++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++++++++A++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++++++++A++++++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++++++++A++++++++++++++++++++++++++++++++++++++          
 
         [0233]     Sequencing of the region from 11)2295752 to H-2296046. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. The polymorphism observed occurs in the pks12 gene and results in a non-conservative substitution.  
                                                                                                                                         30        40        50        60        70        80        90                +---------+---------+---------+---------+---------+---------+            BCG   TGGGCCGCTCTAGATGGGCGCCGCCCCGCGCAGATGCTCGAAGATCAGGGACGTCTGGGTA                   H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   ++T+++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                               100       110       120       130       140       150               ---------+---------+---------+---------+---------+---------+            BCG   CCTGCGACGTCGGCGTCGGCATTGAGGTTTTCGACCACGAACGAACGCAGGTCCTCGGTG               H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        151    160       170       180       190       200               +--------+---------+---------+---------+---------+-            BCG   TCGCGAGCGGCGACGTGCAAGATGAAATCGTCGGCGCC------------                   H37Rv   ++++++++++++++++++++++++++++++++++++++GGCCAGAAAGTAG               CDC1551   ++++++++++++++++++++++++++++++++++++++GGCCAGAAAGTAG               BS   ++++++++++++++++++++++++++++++++++++++GGCCAGAAAGTAG               SI   ++++++++++++++++++++++++++++++++++++++GGCCAGAAAGTAG               NINF   ++++++++++++++++++++++++++++++++++++++GGCCAGAAAGTAG                              210       220       230       240       250               --------+---------+---------+---------+---------+                BCG   ----------CTGCCGTTTGCGGCGGATCTGCTGGATGAAGCTGCGGA                           H37Rv   ACATCCATCAC+++++++++++++++++++++++++++++++++++++                       CDC1551   ACATCCATCAC+++++++++++++++++++++++++++++++++++++                       BS   ACATCCATCAC+++++++++++++++++++++++++++++++++++++                       SI   ACATCCATCAC+++++++++++++++++++++++++++++++++++++                       NINF   ACATCCATCAC+++++++++++++++++++++++++++++++++++++          
 
         [0234]     Sequencing of the region from H-3086111 to H-3086539. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. The SNP seen in H37Rv occurs in a non-coding region while the deletion in BCG leads to truncation of the transcription regulator.  
                                                     180      190       200       210       220       230       240       250       260       270                +---------+---------+---------+---------+---------+---------+---------+---------+---------+            BCG    CGGTCGCGGGCGAAGCGTTTGAAGTCCACCGTCGCCAGGCCGCTGGTCATGGCGCTGGCCTGATCCCACAGACCCCAGCCCAGGGAGATGG                   H37Rv    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++               CDC1551    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++               SI    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++               NIF    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++               NINF    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++               BS    +++++++++++++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0235]     Sequencing of the region from H-2295062 to H-2295633. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; A2313: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF:North Indian Fatal. The SNP observed occurs in the pks12 gene and results in a non-conservative substitution.  
                                                                                 80        90       100       110       120       130       140               -+---------+---------+---------+---------+---------+---------+            BCG   CGGCGAGTACAACGACGCTCGGGTCGATGTCCCGGTCCGATGGCTGCACGGCACCG-AGATC                   H37Rv   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++               CDC1551   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++               BS   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++               SI   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++               NINF   ++++++++++++++++++++++++++++++++++++++++++++++++++++++++G+++++                               150       160       170       180       190       200               ---------+---------+---------+---------+---------+---------+            BCG   CGGTGATCACGCCCGACCTGCTGGACGGCTATGCCGAGCGGGCCAGCGATTTCGAGGTGG                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0236]     Sequencing of the region from H-162341 to H-162761. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain. The deletion in BCG occurs in the region corresponding to a gene with putative enzyme activity and results in a loss of function in BCG.  
                                                                                                             120     130       140       150       160       170       180       190       200       210                +---------+---------+---------+---------+---------+---------+---------+---------+---------+            BCG   CGCCCGCGCCACGACGTCACTACGCACATTCTATTCCGGAGACCCAGGCGAGGCGTCGGGGCGGCACCGTTTGCAGGCCCGGAATCCCTCC                   H37Rv   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NTNF   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   ++++++++++++++++++++++++++++++++C++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        211     220       230       240       250       260       270       280       290       300               +---------+---------+---------+---------+---------+---------+---------+---------+---------+            BCG    CCCTGAGCGGCCGCCGCAGTCGGCAGGAACCGGACATTGCGCGCGAACGGTGGCCGGACGGGGCAACTCGGCCGGCAGTAGACACCGGTG                   H37Rv    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               CDC1551    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               BS    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NTNF    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               SI    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++               NIF    ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++                        301     310       320       330       340       350       360       370       380       390               +---------+---------+---------+---------+---------+---------+---------+---------+---------+            BCG    GTCAAAACCGCGACGACGAACCAGCCGTCGAACCGGGCGTCTTTGGACTGGACCGCCCGGTAGCAGCGTTCGAAGTCGTCGTGCACCCTT                   H37Rv    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++               CDC1551    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++               BS    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++               NTNF    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++               SI    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++               NIF    ++++++++++++++++++++++++++++++++++++++++++++++++++++T++++++++++++++++++++++++++++++++++++          
 
         [0237]     Sequencing of -the region from H-1478664 to H-1479140. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NIN: non-lethal North Indian strain; NIF:North Indian Fatal. The first T to C transition results in the truncation of the bacterial regulatory protein in BCG.  
                                                                                 170     180       190       200       210       220               +---------+---------+---------+---------+---------+-----            BCG   CCACCTCGGTGGTGTTCGCCACCGCCCACTACGCGCTGGTGGATTTGGCCGACGTA                   H37Rv   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT               CDC1551   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT               NINF   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT               BS   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT               SI   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT               NIF   +++++++++++++++++++++++++++++++++++++++++++++++++++CT+CT                          230       240       250       260       270       280               ----+---------+---------+---------+---------+---------+            BCG   CAACCGGGCCAGCGCGTGTTGATCCATGCCGGCACCGGCGGGGTGGGCATGGCGG                   CDC1551   AGGT++++++++++++++++++++++++++++++++++++++++++++++++++               NINF   AGGT++++++++++++++++++++++++++++++++++++++++++++++++++               BS   AGGT++++++++++++++++++++++++++++++++++++++++++++++++++               SI   AGGT++++++++++++++++++++++++++++++++++++++++++++++++++               NIF   AGGT++++++++++++++++++++++++++++++++++++++++++++++++++          
 
         [0238]     Sequencing of the region from H-2296260 to H-2296692. Sequences are amplified from different strains. BCG:  M.bovis  BCG; H37Rv:  M.tuberculosis  strain H37Rv sequence from NCBI database; CDC: CDC1551; S.I: South Indian strain A2313; BS: Beijing strain; NINF: non-lethal North Indian strain; NIF:North Indian Fatal strain. The long polymorphism observed in the pks12 gene but does not alter the activity of the polyketide synthase enzyme. A total of 2755 polymorphisms including 1779 in ORFs and 313 in regions outside the ORF are being screened for association to virulence and/or infectivity in tuberculosis. A multicomponent analysis to determine the association of polymorphism to the degree. of virulence and infectivity is in progress. The polymorphisms which constitute a set of virulence markers are further being validated in 120 clinical isolates of tuberculosis.  
         [0239]     The virulence factors thus identified could be used as:  
         [0240]     i. Diagnostic markers in prediction of disease and its progress in the patient.  
         [0241]     ii. Drug targets for development of new and effective treatments for TB.  
         [0242]     iii. Candidate genes/sequences in DNA vaccine.  
         [0243]     iv. In development of SiRNA technology for combating tuberculosis.  
                                                                                                                                                             TABLE 1                           List of SNP&#39;s in  Mycobacterium tuberculosis / M. bovis  BCG.                            De-                           scrip-       Poly-               tion       mor-   BCG   H37Rv   CDC   of            phism   SNP           SNP           SNP           SNP   SNP               ID   Position   Base   AA   Position   Base   AA   Position   Base   AA   ORF   type   GO ID   Putative Function                    1   467   G   R   467   A   H   467   A   H   Yes   NS, NC   P49993   nucleotide binding                                                           activity       2   1057   A   I   1057   G   V   1057   G   V   Yes   NS, C   P49993   nucleotide binding                                                           activity       3   2347   G   G   2347   A   D   2347   A   D   Yes   NS, NC   Q50790   DNA binding activity       4   2532   C   L   2532   T   L   2532   T   L   Yes   S, NULL   Null   —       5   3751   G   V   3751   T   L   3751   T   L   Yes   NS, C   Q59586   DNA binding activity       6   4480   T   L   4480   C   S   4480   C   S   Yes   NS, NC   P71573   —       7   5752   A   V   5752   G   V   5752   G   V   Yes   S, NULL   Null   —       8   6406   T   N   6406   C   N   6406   C   N   Yes   S, NULL   Null   —       9   6446   T   S   6446   G   A   6446   G   A   Yes   NS, NC   P41514   nucleic acid binding                                                           activity       10   8285   T   I   8285   C   I   8285   C   I   Yes   S, NULL   Null   —       11   8741   T   R   8741   C   R   8741   C   R   Yes   S, NULL   Null   —       12   9143   C   I   9143   T   I   9143   T   I   Yes   S, NULL   Null   —       13   9217   C   A   9217   A   D   9217   A   D   Yes   NS, NC   Q07702   DNA binding activity       14   10727   G   V   10727   A   I   10727   A   I   Yes   NS, C   P71575   integral to membrane       15   13197   C   Null   13197   G   Null   13197   G   null   Yes   S, NULL   Null   —       16   13459   G   D   13460   A   D   13460   A   D   Yes   S, NULL   Null   —       17   14400   G   E   14401   A   K   14401   A   K   Yes   NS, NC   P71582   integral to membrane       18   15116   G   M   15117   C   I   15117   C   I   Yes   NS, NC   P71583   enzyme activity       19   17856   C   T   17857   T   T   17857   T   T   Yes   S, NULL   Null   —       20   21818   C   A   21819   A   S   21819   A   S   Yes   NS, NC   P71588   enzyme activity       21   22263   G   A   22264   T   A   22264   T   A   Yes   S, NULL   Null   —       22   23173   A   L   23174   C   R   23174   C   null   Yes   NS, NC   P71588   enzyme activity       23   23713   T   L   23714   C   L   23714   C   L   Yes   S, NULL   Null   —       24   24293   T   Q   24294   C   R   24294   C   R   Yes   NS, NC   P71590   —       25   24533   C   C   24534   T   Y   24534   T   Y   Yes   NS, NC   P71590   —       26   24678   G   H   24679   A   Y   24679   A   Y   Yes   NS, C   P71590   —       27   24761   C   G   24780   T   D   24762   T   D   Yes   NS, NC   P71590   —       28   25287   G   R   25306   C   G   25288   C   G   Yes   NS, NC   P71590   —       29   26034   G   P   26053   C   A   26035   C   A   Yes   NS, NC   P71591   electron transport       30   27450   G   Null   27469   A   Null   27451   A   null   No   nc, NULL   Null   —       31   29442   T   L   29462   C   P   29444   C   P   Yes   NS, NC   P71595   —       32   29979   C   P   29999   A   Q   29980   A   Q   Yes   NS, NC   P71596   —       33   30736   A   K   30756   G   K   30737   G   K   Yes   S, NULL   Null   —       34   31041   G   R   31057   C   R   31038   C   R   Yes   S, NULL   Null   —       35   32608   A   N   32624   C   H   32568   C   N   Yes   NS, NC   P71599   —       36   33788   A   Null   33804   G   Null   33748   G   null   No   nc, NULL   Null   —       37   36288   G   A   36304   T   A   36248   T   A   Yes   S, NULL   Null   —       38   36522   C   S   36538   T   S   36482   T   S   Yes   S, NULL   Null   —       39   36596   G   K   36612   A   K   36556   A   K   Yes   S, NULL   Null   —       40   39742   G   H   39758   A   H   39702   A   H   Yes   S, NULL   Null   —       41   41228   A   Null   41244   C   Null   41188   C   null   No   nc, NULL   Null   —       42   41437   T   G   41453   C   G   41397   C   G   Yes   S, NULL   Null   —       43   42265   A   F   42281   C   C   42225   C   C   Yes   NS, NC   P71696   integral to membrane       44   43929   G   V   43943   A   V   43889   A   V   Yes   S, NULL   Null   —       45   45177   A   A   45191   G   A   45137   G   A   Yes   S, NULL   Null   —       46   49989   A   Null   50003   G   Null   49949   G   null   No   nc, NULL   Null   —       47   52012   T   S   52026   C   G   51972   C   G   Yes   NS, NC   P71705   integral to membrane       48   53663   T   L   53677   C   P   53623   C   P   Yes   NS, NC   P71707   enzyme activity       49   59861   A   Null   59869   G   Null   59815   G   null   No   nc, NULL   Null   —       50   62758   G   G   62766   A   G   62712   A   G   Yes   S, NULL   Null   —       51   63029   T   Null   63037   C   Null   62983   C   null   No   nc, NULL   Null   —       52   63049   G   Null   63057   C   Null   63003   C   null   No   nc, NULL   Null   —       53   65857   A   I   65865   G   V   65811   G   V   Yes   NS, C   O53607   hydrolase activity       54   69913   T   I   69921   C   T   69867   C   T   Yes   NS, NC   O53609   molecular_function                                                           unknown       55   70082   G   P   70090   A   P   70036   A   P   Yes   S, NULL   Null   —       56   70257   T   F   70265   G   V   70211   G   V   Yes   NS, NC   O53609   molecular_function                                                           unknown       57   71758   T   Null   71729   C   Null   71712   C   null   No   nc, NULL   Null   —       58   74119   T   L   74090   C   L   74073   C   L   Yes   S, NULL   Null   —       59   74188   G   N   74159   C   K   74142   C   K   Yes   NS, NC   O53611   isocitrate                                                           dehydrogenase                                                           (NADP+) activity       60   78130   C   G   78101   T   E   78084   T   E   Yes   NS, NC   O53615   glycine                                                           hydroxymethyltransferase                                                           activity       61   79388   C   Null   79359   G   Null   79342   G   null   No   nc, NULL   Null   —       62   80169   T   P   80131   C   P   80123   C   P   Yes   S, NULL   Null   —       63   86899   G   V   86862   A   I   86854   A   I   Yes   NS, C   O53623   DNA binding activity       64   89235   T   V   89198   G   G   89190   G   G   Yes   NS, C   O53625   —       65   89570   T   Null   89533   C   Null   89525   C   null   No   nc, NULL   Null   —       66   90964   T   V   90927   C   A   90919   C   A   Yes   NS, C   Q10880   oxidative                                                           phosphorylation       67   92357   T   C   92320   A   Null   92312   A   null   Yes   nc, NULL   Null   —       68   94338   C   T   94301   T   M   94293   T   M   Yes   NS, NC   Q10883   oxidative                                                           phosphorylation       69   96136   A   I   96099   G   V   96091   G   null   Yes   NS, C   Q10884   electron transport       70   97731   C   Null   97694   T   Null   97686   T   null   No   nc, NULL   Null   —       71   99336   T   Null   99299   C   Null   99291   C   null   Yes   nc, NULL   Null   —       72   100624   G   A   100587   A   T   100579   A   T   Yes   NS, NC   Q10876   magnesium ion binding                                                           activity       73   103635   G   R   103598   A   C   103590   A   C   Yes   NS, NC   Q10890   integral to membrane       74   105903   T   W   105865   C   R   105857   C   R   Yes   NS, NC   Q10892   integral to membrane       75   106370   A   P   106332   C   P   106324   C   P   Yes   S, NULL   Null   —       76   122650   T   W   122612   C   R   122604   C   R   Yes   NS, NC   Q10898   cAMP-dependent                                                           protein kinase complex       77   123556   C   H   123518   T   Y   123510   T   Y   Yes   NS, C   Q10898   cAMP-dependent                                                           protein kinase complex       78   123878   T   Null   123840   C   Null   123832   C   null   No   nc, NULL   Null   —       79   126600   A   S   126561   C   A   126554   C   A   Yes   NS, NC   Q10900   magnesium ion binding                                                           activity       80   126840   G   P   126801   A   S   126794   A   S   Yes   NS, NC   Q10900   magnesium ion binding                                                           activity       81   127447   G   L   127408   C   L   127401   C   L   Yes   S, NULL   Null   —       82   130172   A   V   130133   G   A   130126   G   A   Yes   NS, C   Q10900   magnesium ion binding                                                           activity       83   130237   T   P   130198   C   P   130191   C   P   Yes   S, NULL   Null   —       84   137223   A   Q   137183   G   Q   137177   G   Q   Yes   S, NULL   Null   —       85   138339   A   R   138299   G   G   138292   G   G   Yes   NS, NC   O53636   —       86   139796   C   Null   139754   T   Null   139747   T   null   No   nc, NULL   Null   —       87   143247   C   G   143205   T   S   143198   T   S   Yes   NS, NC   O53639   DNA binding activity       88   146006   A   A   145964   G   A   145957   G   A   Yes   S, NULL   Null   —       89   147495   A   W   147453   C   W   147446   C   W   Yes   S, NULL   Null   —       90   147911   C   Null   147871   A   Null   147864   A   null   No   nc, NULL   Null   —       91   149987   G   G   149947   C   G   149940   C   G   Yes   S, NULL   Null   —       92   159370   A   F   159177   G   F   159350   G   F   Yes   S, NULL   Null   —       93   160535   T   K   160342   C   E   160515   C   E   Yes   NS, NC   P96809   —       94   161144   T   F   160951   G   V   161124   G   V   Yes   NS, NC   P96810   N-acetyltransferase                                                           activity       95   162499   A   R   162306   G   G   162479   G   G   Yes   NS, NC   P96811   enzyme activity       96   162530   G   G   162337   A   D   162510   A   D   Yes   NS, NC   P96811   enzyme activity       97   165799   G   G   165607   A   D   165780   A   D   Yes   NS, NC   P96815   —       98   166696   A   H   166504   G   R   166677   G   R   Yes   NS, NC   P96816   —       99   170273   G   L   170081   A   F   170254   A   F   Yes   NS, NC   P96820   voltage-gated chloride                                                           channel activity       100   171097   C   R   170905   A   R   171078   A   R   Yes   S, NULL   Null   —       101   173091   A   R   172899   C   R   173072   C   R   Yes   S, NULL   Null   —       102   179424   T   R   179232   C   G   179405   C   G   Yes   NS, NC   P96828   —       103   181862   C   G   181670   T   D   181843   T   D   Yes   NS, NC   P96830   protein phosphatase                                                           activity       104   184917   G   C   184725   A   Y   184895   A   null   Yes   NS, NC   P96833   —       105   188267   T   T   188075   G   P   188245   G   P   Yes   NS, NC   O53642   —       106   189999   T   T   189807   C   A   189977   C   A   Yes   NS, NC   O86360   —       107   190284   T   T   190092   C   A   190262   C   A   Yes   NS, NC   O86360   —       108   192177   A   L   191985   G   L   192156   G   L   Yes   S, NULL   Null   —       109   195552   C   A   195358   T   V   195529   T   V   Yes   NS, C   O07411   enzyme activity       110   195758   G   A   195564   T   S   195735   T   S   Yes   NS, NC   O07411   enzyme activity       111   198328   A   I   198134   C   I   198305   C   I   Yes   S, NULL   Null   —       112   199662   G   A   199468   T   S   199639   T   S   Yes   NS, NC   P72013   pathogenesis       113   199800   T   S   199606   C   P   199777   C   P   Yes   NS, NC   P72013   pathogenesis       114   200622   C   T   200428   T   I   200599   T   I   Yes   NS, NC   O07414   pathogenesis       115   201759   C   D   201565   G   E   201736   G   E   Yes   NS, C   O07415   pathogenesis       116   206673   G   P   206479   C   P   206650   C   P   Yes   S, NULL   Null   —       117   206676   T   G   206482   G   G   206653   G   G   Yes   S, NULL   Null   —       118   210634   T   H   210440   C   R   210554   C   R   Yes   NS, NC   O07423   —       119   212446   A   Null   212252   G   Null   212366   G   null   No   nc, NULL   Null   —       120   217393   C   N   217199   T   N   217313   T   N   Yes   S, NULL   Null   —       121   218055   G   R   217861   C   P   217975   C   P   Yes   NS, NC   O07430   hydrolase activity       122   225861   T   S   225666   C   G   225780   C   G   Yes   NS, NC   O07437   —       123   227215   G   V   227020   A   I   227134   A   I   Yes   NS, C   O53645   nucleotide binding                                                           activity       124   227738   T   M   227543   C   T   227657   C   T   Yes   NS, NC   O53645   nucleotide binding                                                           activity       125   228053   T   L   227858   C   P   227972   C   P   Yes   NS, NC   O53645   nucleotide binding                                                           activity       126   228924   T   R   228729   C   R   228843   C   R   Yes   S, NULL   Null   —       127   231783   C   Null   231587   T   Null   231701   T   null   No   nc, NULL   Null   —       128   232188   G   A   231992   C   A   232106   C   A   Yes   S, NULL   Null   —       129   233552   C   V   233356   A   V   233470   A   V   Yes   S, NULL   Null   —       130   233558   C   S   233362   G   R   233476   G   R   Yes   NS, NC   O53648   —       131   243794   G   R   243596   A   H   243712   A   H   Yes   NS, NC   O53656   integral to membrane       132   244589   C   A   244391   T   V   244507   T   V   Yes   NS, C   O53656   integral to membrane       133   246117   C   E   245919   G   D   246035   G   D   Yes   NS, C   O53657   membrane       134   246365   T   I   246167   A   F   246283   A   F   Yes   NS, NC   O53657   membrane       135   249718   C   A   249520   T   V   249636   T   V   Yes   NS, C   P96391   —       136   251771   A   T   251573   G   A   251689   G   A   Yes   NS, NC   P96392   —       137   251865   C   Null   251667   T   Null   251783   T   null   No   nc, NULL   Null   —       138   256378   C   A   256180   G   G   256296   G   G   Yes   NS, C   P96396   enzyme activity       139   259127   A   Null   258900   C   Null   259016   C   null   Yes   nc, NULL   Null   —       140   260507   T   T   260280   G   P   260396   G   P   Yes   NS, NC   P96399   enzyme activity       141   262385   A   N   262158   G   D   262274   G   D   Yes   NS, NC   P96400   electron transport       142   265183   A   D   266857   G   D   266973   G   D   Yes   S, NULL   Null   —       143   265653   A   S   267327   G   P   267443   G   P   Yes   NS, NC   P96405   metabolism       144   266601   C   L   268275   G   F   268391   G   F   Yes   NS, NC   P96406   S-adenosylmethionine-                                                           dependent                                                           methyltransferase                                                           activity       145   269989   T   N   271663   C   S   271779   C   S   Yes   NS, C   P96409   —       146   271077   C   R   272751   G   S   272867   G   S   Yes   NS, NC   P96409   —       147   271882   G   S   273556   C   S   273672   C   S   Yes   S, NULL   Null   —       148   273691   T   E   275365   G   D   275481   G   D   Yes   NS, C   P96413   zinc ion binding activity       149   276186   T   Null   277860   G   Null   277976   G   null   No   nc, NULL   Null   —       150   282208   C   A   283882   T   T   283998   T   T   Yes   NS, NC   P96419   cell adhesion       151   283942   C   V   285616   T   M   285732   T   M   Yes   NS, NC   P96419   cell adhesion       152   285894   T   L   287568   G   V   287684   G   V   Yes   NS, C   O53660   hydrolase activity       153   287276   T   T   288950   C   T   289066   C   T   Yes   S, NULL   Null   —       154   287759   T   S   289433   G   A   289549   G   A   Yes   NS, NC   O53663   —       155   288778   T   L   290452   C   L   290568   C   L   Yes   S, NULL   Null   —       156   292523   G   A   294196   T   E   294313   T   E   Yes   NS, NC   O53666   acyl-CoA                                                           dehydrogenase activity       157   292778   C   R   294451   T   K   294568   T   K   Yes   NS, C   O53666   acyl-CoA                                                           dehydrogenase activity       158   294180   C   Null   295853   A   Null   295970   A   null   No   nc, NULL   Null   —       159   295519   T   V   297192   C   A   297309   C   A   Yes   NS, C   O53668   —       160   300012   T   Null   301685   C   Null   301802   C   null   No   nc, NULL   Null   —       161   301364   T   G   303037   C   G   303154   C   G   Yes   S, NULL   Null   —       162   305428   T   G   307101   C   G   307218   C   G   Yes   S, NULL   Null   —       163   308090   T   Null   309763   C   Null   309880   C   null   Yes   nc, NULL   Null   —       164   311176   A   L   312849   G   L   312966   G   L   Yes   S, NULL   Null   —       165   312194   A   S   313867   G   S   313984   G   S   Yes   S, NULL   Null   —       166   318505   G   I   320178   A   I   320294   A   null   Yes   S, NULL   Null   —       167   321009   T   L   322682   C   L   322798   C   L   Yes   S, NULL   Null   —       168   321631   G   Null   323304   A   Null   323420   A   null   No   nc, NULL   Null   —       169   323830   C   V   325503   T   V   325619   T   V   Yes   S, NULL   Null   —       170   327543   A   L   329216   G   P   329332   G   P   Yes   NS, NC   P95229   —       171   329913   A   L   331586   G   S   331702   G   S   Yes   NS, NC   O53681   —       172   331537   C   Null   333210   G   Null   333326   G   null   Yes   nc, NULL   Null   —       173   331617   G   Null   333290   A   Null   333406   A   null   Yes   nc, NULL   Null   —       174   331719   G   Null   333392   C   Null   333508   C   null   No   nc, NULL   Null   —       175   340088   G   Null   339084   A   Null   339148   A   null   No   nc, NULL   Null   —       176   340090   C   Null   339086   T   Null   339150   T   null   No   nc, NULL   Null   —       177   340091   G   Null   339087   A   Null   339151   A   null   No   nc, NULL   Null   —       178   340092   G   Null   339088   C   Null   339152   C   null   No   nc, NULL   Null   —       179   340097   C   Null   339093   G   Null   339157   G   null   No   nc, NULL   Null   —       180   343148   C   A   342144   A   E   342208   A   null   Yes   NS, NC   O53687   nuoleotide binding                                                           activity       181   344283   C   A   343279   G   A   343343   G   A   Yes   S, NULL   Null   —       182   351491   C   A   350487   G   A   350551   G   A   Yes   S, NULL   Null   —       183   355282   A   T   354278   G   A   354342   G   A   Yes   NS, NC   O86362   —       184   362163   C   Null   361159   T   Null   361223   T   null   No   nc, NULL   Null   —       185   362818   T   F   361814   C   F   361878   C   F   Yes   S, NULL   Null   —       186   364560   A   N   363511   G   S   363575   G   null   Yes   NS, C   O07226   —       187   364804   T   V   363755   C   V   363819   C   V   Yes   S, NULL   Null   —       188   366022   T   V   364973   C   A   365037   C   A   Yes   NS, C   O07229   DNA binding activity       189   367778   C   A   366729   T   T   366793   T   T   Yes   NS, NC   O07231   tRNA ligase activity       190   368518   A   F   367469   G   S   367533   G   S   Yes   NS, NC   O07231   tRNA ligase activity       191   369200   T   S   368166   C   G   368230   C   G   Yes   NS, NC   O07231   tRNA ligase activity       192   373180   A   L   372147   G   L   372211   G   L   Yes   S, NULL   Null   —       193   382060   G   G   381028   A   S   381091   A   S   Yes   NS, NC   O07239   —       194   383273   T   L   382241   C   P   382304   C   P   Yes   NS, NC   O07239   —       195   383519   T   Null   382487   C   Null   382550   C   null   No   nc, NULL   Null   —       196   384021   G   A   382989   A   V   383052   A   V   Yes   NS, C   O07241   —       197   387090   C   Null   386058   T   Null   386120   T   null   No   nc, NULL   Null   —       198   390159   G   C   389127   A   Y   389189   A   Y   Yes   NS, NC   O07247   dCTP deaminase                                                           activity       199   393291   C   Q   392259   T   *   392321   T   *   Yes   NS, TP   O07250   —       200   393536   G   G   392504   A   G   392566   A   G   Yes   S, NULL   Null   —       201   394778   A   Y   393746   G   H   393808   G   H   Yes   NS, C   O08447   monooxygenase activity       202   395965   G   S   394933   C   W   394995   C   W   Yes   NS, NC   O07253   methyltransferase                                                           activity       203   398416   T   Null   397384   C   Null   397446   C   null   No   nc, NULL   Null   —       204   399064   G   G   398032   A   E   398094   A   G   Yes   NS, NC   O07256   —       205   402708   A   H   401676   C   P   401738   C   P   Yes   NS, NC   O33266   nucleic acid binding                                                           activity       206   406818   A   V   405786   C   V   405848   C   V   Yes   S, NULL   Null   —       207   406884   G   Null   405852   C   Null   405914   C   null   No   nc, NULL   Null   —       208   412130   G   S   411098   A   N   411160   A   N   Yes   NS, C   O06293   —       209   413310   G   Q   412278   T   H   412340   T   H   Yes   NS, NC   O06293   —       210   423408   T   L   422377   C   S   422439   C   S   Yes   NS, NC   P32724   chaperone activity       211   423774   C   G   422743   T   G   422805   T   G   Yes   S, NULL   Null   —       212   425964   A   F   424930   T   I   425095   T   I   Yes   NS, NC   O06304   —       213   428488   G   G   427469   T   G   427619   T   G   Yes   S, NULL   Null   —       214   429715   T   A   428696   C   A   428786   C   A   Yes   S, NULL   Null   —       215   430077   C   D   429058   T   N   429148   T   N   Yes   NS, NC   O06304   —       216   438482   C   S   437463   G   S   437553   G   S   Yes   S, NULL   Null   —       217   439288   A   T   438269   G   A   438359   G   A   Yes   NS, NC   O06309   metalloendopeptidase                                                           activity       218   441762   C   A   440743   T   V   440833   T   V   Yes   NS, C   O06312   cation transport       219   443988   C   L   442969   A   I   443059   A   I   Yes   NS, C   O06314   molecular_function                                                           unknown       220   444576   A   V   443557   C   V   443647   C   V   Yes   S, NULL   Null   —       221   446432   T   S   445413   C   G   445503   C   G   Yes   NS, NC   O53703   transporter activity       222   446797   T   H   445778   C   R   445868   C   R   Yes   NS, NC   O53703   transporter activity       223   448459   T   E   447440   C   G   447530   C   G   Yes   NS, NC   O53705   nucleotide binding                                                           activity       224   449922   T   S   448903   C   G   448993   C   G   Yes   NS, NC   O53707   —       225   451132   T   S   450113   C   S   450203   C   S   Yes   S, NULL   Null   —       226   452456   G   S   451437   A   F   451527   A   F   Yes   NS, NC   O53708   electron transport       227   452844   T   A   451825   C   A   451915   C   A   Yes   S, NULL   Null   —       228   456342   G   R   455323   C   P   455414   C   P   Yes   NS, NC   O53712   DNA binding activity       229   456346   C   G   455327   T   G   455418   T   G   Yes   S, NULL   Null   —       230   467343   C   R   466324   T   R   466415   T   R   Yes   S, NULL   Null   —       231   467402   C   A   466383   A   D   466474   A   D   Yes   NS, NC   O53720   DNA binding activity       232   469376   G   G   468355   A   E   468448   A   E   Yes   NS, NC   P95197   purine base                                                           biosynthesis       233   470348   C   T   469327   T   I   469420   T   I   Yes   NS, NC   P95197   purine base                                                           biosynthesis       234   472937   G   A   471916   A   V   472009   A   V   Yes   NS, C   P95200   electron transport       235   474708   A   A   473687   G   A   473780   G   A   Yes   S, NULL   Null   —       236   476885   G   T   475864   C   T   475957   C   T   Yes   S, NULL   Null   —       237   482898   G   P   481878   A   L   481971   A   L   Yes   NS, NC   P95211   membrane       238   485256   G   A   484236   A   T   485687   A   T   Yes   NS, NC   P95213   enzyme activity       239   488897   G   G   487876   T   G   489327   T   G   Yes   S, NULL   Null   —       240   490019   T   T   488998   C   T   490449   C   T   Yes   S, NULL   Null   —       241   490878   G   V   489857   A   M   491308   A   M   Yes   NS, NC   O86335   enzyme activity       242   492761   C   F   491740   T   F   493191   T   F   Yes   S, NULL   Null   —       243   493169   C   A   492148   G   G   493599   G   G   Yes   NS, C   P96254   metabolism       244   495704   C   R   494683   A   R   496134   A   R   Yes   S, NULL   Null   —       245   498127   T   P   497106   C   P   498557   C   P   Yes   S, NULL   Null   —       246   499550   G   A   498529   A   A   499980   A   A   Yes   S, NULL   Null   —       247   502639   T   V   501618   C   A   503069   C   A   Yes   NS, C   P96261   electron transport       248   506993   A   T   505972   G   A   507423   G   A   Yes   NS, NC   P96265   proteolysis and                                                           peptidolysis       249   507929   T   E   506908   C   G   508359   C   G   Yes   NS, NC   P96266   —       250   515676   G   A   514655   T   E   516106   T   E   Yes   NS, NC   P96271   ATP binding activity       251   518377   C   G   517356   T   D   518807   T   D   Yes   NS, NC   P96274   —       252   518430   G   R   517409   A   R   518860   A   R   Yes   S, NULL   Null   —       253   519412   T   T   518391   C   A   519842   C   A   Yes   NS, NC   P96275   protein biosynthesis       254   520204   G   G   519183   T   V   520634   T   V   Yes   NS, C   P96277   —       255   520350   G   A   519329   A   T   520780   A   T   Yes   NS, NC   P96277   —       256   520825   A   A   519804   G   A   521255   G   A   Yes   S, NULL   Null   —       257   522338   C   C   521317   T   C   522768   T   C   Yes   S, NULL   Null   —       258   523100   G   A   522079   A   T   523530   A   T   Yes   NS, NC   P96280   ATP-dependent                                                           peptidase activity       259   528335   G   I   527314   C   M   528765   C   M   Yes   NS, NC   O53725   Mo-molybdopterin                                                           cofactor biosynthesis       260   529373   A   Null   528352   C   Null   529803   C   null   Yes   nc, NULL   Null   —       261   533211   T   Null   532190   C   Null   533641   C   null   Yes   S, NULL   Null   —       262   534258   T   E   533237   C   G   534688   C   G   Yes   NS, NC   O53729   —       263   534489   T   D   533468   C   G   534919   C   G   Yes   NS, NC   O53729   —       264   535446   A   Null   534425   T   Null   535876   T   null   No   nc, NULL   Null   —       265   540882   G   S   539861   A   S   541312   A   S   Yes   S, NULL   Null   —       266   540902   G   L   539881   A   L   541332   A   L   Yes   S, NULL   Null   —       267   541571   T   T   540550   C   A   542001   C   A   Yes   NS, NC   O53735   membrane       268   544180   C   Null   543159   T   Null   544610   T   null   No   nc, NULL   Null   —       269   547376   G   T   546355   A   T   547806   A   T   Yes   S, NULL   Null   —       270   556349   T   Q   555328   C   R   556779   C   R   Yes   NS, NC   O53750   DNA binding activity       271   557010   G   R   555989   A   C   557440   A   C   Yes   NS, NC   O53750   DNA binding activity       272   557220   C   D   556199   T   N   557650   T   N   Yes   NS, NC   O53750   DNA binding activity       273   558318   A   Null   557297   G   Null   558748   G   null   No   nc, NULL   Null   —       274   561876   G   L   560855   C   L   562305   C   L   Yes   S, NULL   Null   —       275   562317   T   A   561296   C   A   562746   C   A   Yes   S, NULL   Null   —       276   566174   A   G   565153   C   G   566603   C   G   Yes   S, NULL   Null   —       277   566423   T   R   565402   G   R   566852   G   R   Yes   S, NULL   Null   —       278   574240   C   T   573275   G   T   574725   G   T   Yes   S, NULL   Null   —       279   574347   G   L   573382   T   I   574832   T   I   Yes   NS, C   Q11150   metabolism       280   582972   A   F   581819   G   L   583188   G   L   Yes   NS, NC   Q11157   electron transporter                                                           activity       281   583372   C   G   582219   T   G   583588   T   G   Yes   S, NULL   Null   —       282   584969   T   Q   583816   C   Q   585186   C   Q   Yes   S, NULL   Null   —       283   585322   C   G   584169   T   S   585539   T   S   Yes   NS, NC   Q11158   —       284   585662   T   T   584509   G   T   585879   G   T   Yes   S, NULL   Null   —       285   591914   C   D   590761   G   E   592131   G   E   Yes   NS, C   Q11141   pyrroline 5-carboxylate                                                           reductase activity       286   598704   C   H   597551   G   D   598920   G   D   Yes   NS, NC   Q11171   membrane       287   599874   T   Y   598721   G   D   600090   G   D   Yes   NS, NC   Q11171   membrane       288   600514   G   C   599361   C   S   600730   C   S   Yes   NS, NC   Q11171   membrane       289   601019   G   R   599866   A   R   601235   A   R   Yes   S, NULL   Null   —       290   606489   G   G   605336   A   E   606705   A   E   Yes   NS, NC   O33357   porphobilinogen                                                           synthase activity       291   610514   T   H   609361   C   H   610730   C   H   Yes   S, NULL   Null   —       292   611077   A   D   609924   G   G   611293   G   G   Yes   NS, NC   O33362   transferase activity       293   612523   C   Q   611371   T   Q   612740   T   Q   Yes   S, NULL   Null   —       294   622386   C   S   621234   G   S   622603   G   S   Yes   S, NULL   Null   —       295   624971   T   G   623726   G   G   625179   G   G   Yes   S, NULL   Null   —       296   625445   T   G   624200   C   G   625653   C   G   Yes   S, NULL   Null   —       297   631262   G   Null   630016   A   Null   631469   A   null   No   nc, NULL   Null   —       298   631931   T   P   630685   G   P   632138   G   P   Yes   S, NULL   Null   —       299   634973   C   V   633727   T   I   635181   T   I   Yes   NS, C   O06407   —       300   641373   T   Null   640127   C   Null   641581   C   null   No   nc, NULL   Null   —       301   644245   C   R   643000   G   R   644454   G   R   Yes   S, NULL   Null   —       302   645682   T   A   644437   C   A   645891   C   A   Yes   S, NULL   Null   —       303   649910   T   D   648665   C   D   650119   C   D   Yes   S, NULL   Null   —       304   650099   C   G   648854   T   G   650308   T   G   Yes   S, NULL   Null   —       305   654178   T   G   652933   C   G   654387   C   G   Yes   S, NULL   Null   —       306   657229   G   Null   655984   T   Null   657438   T   null   No   nc, NULL   Null   —       307   658821   G   D   657576   A   D   659030   A   D   Yes   S, NULL   Null   —       308   660166   G   L   658921   C   F   660375   C   F   Yes   NS, NC   O53764   methyltransferase                                                           activity       309   660584   C   Null   659339   T   Null   660793   T   null   No   nc, NULL   Null   —       310   664154   C   A   662909   T   A   664363   T   A   Yes   S, NULL   Null   —       311   668104   G   F   666860   A   F   668313   A   F   Yes   S, NULL   Null   —       312   669625   C   K   668381   A   N   669834   A   N   Yes   NS, NC   O53771   —       313   671788   A   H   670543   G   R   671996   G   R   Yes   NS, NC   O53773   DNA binding activity       314   673323   A   P   672078   G   P   673531   G   P   Yes   S, NULL   Null   —       315   673880   T   T   672635   C   A   674088   C   A   Yes   NS, NC   O53775   subtilase activity       316   677219   G   Null   675974   A   Null   677427   A   null   Yes   nc, NULL   Null   —       317   680416   C   Null   679171   T   Null   680624   T   null   No   nc, NULL   Null   —       318   680740   G   G   679495   A   D   680948   A   D   Yes   NS, NC   O86365   nitrogen fixation       319   685069   T   I   683824   C   M   685275   C   I   Yes   NS, NC   O53781   —       320   685533   G   Null   684288   A   Null   685739   A   null   Yes   nc, NULL   Null   —       321   688596   C   P   687351   T   L   688802   T   L   Yes   NS, NC   O07789   pathogenesis       322   690448   T   M   689202   C   T   690653   C   T   Yes   NS, NC   O07787   pathogenesis       323   691492   A   N   690246   C   T   691695   C   N   Yes   NS, C   O07787   pathogenesis       324   691694   C   A   690448   A   A   691888   A   null   Yes   S, NULL   Null   —       325   693833   T   *   692586   C   Q   694036   C   Q   Yes   NS, TP   O07785   pathogenesis       326   700963   T   I   699716   C   V   701166   C   V   Yes   NS, C   O07776   two-component                                                           response regulator                                                           activity       327   701329   G   A   700082   C   P   701532   C   null   Yes   NS, NC   O07775   —       328   701386   A   K   700139   G   E   701589   G   null   Yes   NS, NC   O07775   —       329   702021   C   P   700774   T   S   702224   T   S   Yes   NS, NC   O07774   —       330   706847   C   S   705600   T   N   707048   T   N   Yes   NS, C   O07767   —       331   712319   T   A   711072   C   A   712520   C   A   Yes   S, NULL   Null   —       332   713327   G   G   712080   C   R   713528   C   null   Yes   NS, NC   O07759   UTP-hexose-1-                                                           phosphate                                                           uridylyltransferase                                                           activity       333   713374   C   A   712127   G   A   713575   G   null   Yes   S, NULL   Null   —       334   714556   C   R   713308   T   C   714756   T   C   Yes   NS, NC   P96910   galactokinase activity       335   715048   T   C   713800   C   R   715248   C   R   Yes   NS, NC   P96910   galactokinase activity       336   716512   G   W   715264   A   Null   716712   A   W   Yes   nc, NULL   Null   —       337   718834   G   V   717586   A   V   719034   A   V   Yes   S, NULL   Null   —       338   720904   T   V   719656   C   V   721104   C   V   Yes   S, NULL   Null   —       339   721373   C   A   720125   T   T   721573   T   T   Yes   NS, NC   P96919   RNA binding activity       340   722454   T   G   721206   C   G   722654   C   G   Yes   S, NULL   Null   —       341   723170   G   F   721922   A   F   723370   A   F   Yes   S, NULL   Null   —       342   723828   A   F   722581   C   V   724029   C   V   Yes   NS, NC   P96920   DNA binding activity       343   726039   A   L   724792   C   V   726240   C   V   Yes   NS, C   P96920   DNA binding activity       344   726979   A   L   725732   G   P   727180   G   P   Yes   NS, NC   P96921   helicase activity       345   728566   T   E   727319   C   G   728767   C   G   Yes   NS, NC   P96921   helicase activity       346   730359   A   G   729112   G   G   730559   G   G   Yes   S, NULL   Null   —       347   733788   G   A   732550   A   T   733997   A   T   Yes   NS, NC   P96927   cysteine-type                                                           endopeptidase activity       348   737101   G   A   735863   A   T   737310   A   T   Yes   NS, NC   P96932   RNA binding activity       349   737549   T   P   736311   C   P   737753   C   P   Yes   S, NULL   Null   —       350   738155   T   L   736917   G   F   738359   G   F   Yes   NS, NC   P72028   methyltransferase                                                           activity       351   740056   A   L   738818   C   R   740260   C   R   Yes   NS, NC   P72026   methyltransferase                                                           activity       352   742977   T   T   741739   C   A   743181   C   A   Yes   NS, NC   P96936   —       353   745086   T   L   743315   C   S   745290   C   S   Yes   NS, NC   P96937   alpha-mannosidase                                                           activity       354   746998   A   P   745227   G   P   747202   G   P   Yes   S, NULL   Null   —       355   747114   G   R   745343   C   P   747318   C   P   Yes   NS, NC   P96937   alpha-mannosidase                                                           activity       356   758951   G   G   757180   A   D   759155   A   D   Yes   NS, NC   O06776   metabolism       357   764800   C   A   763029   T   A   765004   T   A   Yes   S, NULL   Null   —       358   770931   G   P   769160   A   S   771136   A   null   Yes   NS, NC   O06769   —       359   771448   C   Null   769677   A   Null   771653   A   null   No   nc, NULL   Null   —       360   772157   A   A   770386   G   A   772362   G   A   Yes   S, NULL   Null   —       361   774665   A   L   772894   G   L   774870   G   L   Yes   S, NULL   Null   —       362   777869   A   I   776098   G   T   778074   G   T   Yes   NS, NC   O53784   membrane       363   784766   A   A   782995   G   A   784971   G   A   Yes   S, NULL   Null   —       364   788162   G   S   786391   T   I   788367   T   I   Yes   NS, NC   P95032   —       365   800584   T   Null   798813   C   Null   800788   C   null   No   nc, NULL   Null   —       366   804997   T   G   803173   C   G   805364   C   G   Yes   S, NULL   Null   —       367   808276   T   L   806452   G   L   808643   G   L   Yes   S, NULL   Null   —       368   808601   T   *   806777   G   E   808968   G   E   Yes   NS, TP   P95059   metabolism       369   811737   C   Null   809913   A   Null   812104   A   null   No   nc, NULL   Null   —       370   812709   G   Null   810885   A   Null   813076   A   null   No   nc, NULL   Null   —       371   816925   T   R   815101   C   R   817293   C   R   Yes   S, NULL   Null   —       372   817058   C   T   815234   T   I   817426   T   I   Yes   NS, NC   P95071   structural constituent of                                                           ribosome       373   817673   G   R   815849   A   R   818041   A   null   Yes   S, NULL   Null   —       374   822574   T   H   820750   C   R   822942   C   R   Yes   NS, NC   O86322   serine biosynthesis       375   823729   C   P   821905   T   L   824097   T   L   Yes   NS, NC   O53793   carbohydrate                                                           metabolism       376   828003   C   L   826179   G   L   828371   G   L   Yes   S, NULL   Null   —       377   833390   G   V   831564   A   M   833756   A   M   Yes   NS, NC   O53802   —       378   834025   T   D   832199   C   D   834390   C   D   Yes   S, NULL   Null   —       379   834070   G   Q   832244   A   Q   834435   A   Q   Yes   S, NULL   Null   —       380   836836   T   Null   835010   A   Null   837201   A   null   No   nc, NULL   Null   —       381   837652   T   V   835826   C   A   838017   C   A   Yes   NS, C   O53809   —       382   839308   A   N   837578   G   S   839769   G   S   Yes   NS, C   O53809   —       383   846049   C   V   843857   T   I   846000   T   I   Yes   NS, C   O53815   acyl-CoA                                                           dehydrogenase activity       384   846399   G   A   844207   A   V   846350   A   V   Yes   NS, C   O53815   acyl-OcA                                                           dehydrogenase activity       385   846819   C   G   844627   A   V   846770   A   V   Yes   NS, C   O53816   metabolism       386   850185   C   Null   847993   T   Null   850136   T   null   No   nc, NULL   Null   —       387   850597   T   K   848405   C   R   850548   C   R   Yes   NS, C   O53818   —       388   853294   T   A   851102   C   A   853245   C   A   Yes   S, NULL   Null   —       389   853752   A   Null   851560   G   Null   853703   G   null   No   nc, NULL   Null   —       390   854796   A   I   852604   G   I   854747   G   I   Yes   S, NULL   Null   —       391   854797   T   I   852605   G   I   854748   G   I   Yes   S, NULL   Null   —       392   856687   A   F   854496   G   F   856638   G   F   Yes   S, NULL   Null   —       393   864764   T   V   862573   C   A   864715   C   A   Yes   NS, C   P71824   metabolism       394   865821   G   G   863630   T   V   865772   T   V   Yes   NS, C   P71825   valine metabolism       395   869886   C   A   867695   A   S   869837   A   S   Yes   NS, NC   P71829   enzyme activity       396   870116   G   A   867925   T   D   870067   T   D   Yes   NS, NC   P71829   enzyme activity       397   870460   C   A   868269   T   A   870411   T   A   Yes   S, NULL   Null   —       398   873460   C   P   871269   A   T   873411   A   T   Yes   NS, NC   P71832   enzyme activity       399   879911   A   L   877718   G   L   879862   G   L   Yes   S, NULL   Null   —       400   879912   A   G   877719   G   G   879863   G   G   Yes   S, NULL   Null   —       401   895718   C   S   894886   T   S   894797   T   null   Yes   S, NULL   Null   —       402   901045   G   R   900213   C   R   900124   C   R   Yes   S, NULL   Null   —       403   904341   G   V   903509   C   V   903420   C   V   Yes   S, NULL   Null   —       404   905912   C   G   905080   G   G   904991   G   G   Yes   S, NULL   Null   —       405   912091   C   P   911259   T   L   911170   T   L   Yes   NS, NC   O53830   two-component                                                           response regulator                                                           activity       406   913660   G   L   912828   C   F   912739   C   F   Yes   NS, NC   O53832   nucleotide binding                                                           activity       407   914104   G   S   913272   C   S   913183   C   S   Yes   S, NULL   Null   —       408   916876   G   P   916044   T   H   915955   T   H   Yes   NS, NC   O53834   —       409   917180   A   Null   916348   G   Null   916259   G   null   No   nc, NULL   Null   —       410   917489   G   L   916657   A   F   916568   A   F   Yes   NS, NC   O53835   molecular_function                                                           unknown       411   917544   T   L   916712   G   L   916623   G   L   Yes   S, NULL   Null   —       412   918089   A   C   917257   C   G   917168   C   G   Yes   NS, NC   O53835   molecular_function                                                           unknown       413   919629   C   Null   918797   T   Null   918708   T   null   No   nc, NULL   Null   —       414   920661   T   R   919829   C   R   919740   C   R   Yes   S, NULL   Null   —       415   920753   G   G   919921   A   E   919832   A   E   Yes   NS, NC   O53837   —       416   921344   A   Q   920512   G   R   920423   G   R   Yes   NS, NC   O53837   —       417   925130   A   Null   924298   G   Null   924209   G   null   No   nc, NULL   Null   —       418   928734   C   Null   927830   T   Null   927741   T   null   No   nc, NULL   Null   —       419   929147   T   G   928396   G   G   928298   G   G   Yes   S, NULL   Null   —       420   930497   T   A   929746   C   A   929648   C   A   Yes   S, NULL   Null   —       421   931872   C   Y   931121   T   Y   931023   T   Y   Yes   S, NULL   Null   —       422   932186   G   G   931435   A   D   931337   A   D   Yes   NS, NC   O53846   —       423   933001   A   P   932250   C   Null   932152   C   null   Yes   nc, NULL   Null   —       424   933029   C   W   932278   T   *   932180   T   *   Yes   NS, TP   O53848   —       425   934448   T   G   933697   G   G   933599   G   G   Yes   S, NULL   Null   —       426   934979   G   Null   934228   C   Null   934130   C   null   No   nc, NULL   Null   —       427   934982   A   Null   934231   G   Null   934133   G   null   No   nc, NULL   Null   —       428   935360   T   Null   934609   G   Null   934511   G   null   No   nc, NULL   Null   —       429   938432   T   F   937675   G   F   937577   G   V   Yes   S, NULL   Null   —       430   939001   G   L   938244   A   L   938146   A   L   Yes   S, NULL   Null   —       431   940714   G   G   939957   A   D   939859   A   D   Yes   NS, NC   O53855   metabolism       432   941068   A   D   940311   C   A   940213   C   A   Yes   NS, NC   O53855   metabolism       433   941645   G   P   940888   C   A   940790   C   A   Yes   NS, NC   O53856   two-component                                                           response regulator                                                           activity       434   942600   A   E   941843   C   A   941745   C   A   Yes   NS, NC   O53857   ATP binding activity       435   943719   G   H   942962   A   Y   942864   A   Y   Yes   NS, C   O53858   copper ion binding                                                           activity       436   945051   G   Null   944294   A   Null   944196   A   null   No   nc, NULL   Null   —       437   945480   T   V   944723   C   A   944625   C   A   Yes   NS, C   O53859   —       438   946102   G   G   945345   T   V   945247   T   null   Yes   NS, C   O53860   amino acid metabolism       439   948022   T   F   947265   C   F   947165   C   null   Yes   S, NULL   Null   —       440   948049   C   G   947292   T   G   947192   T   null   Yes   S, NULL   Null   —       441   948974   A   F   948217   C   V   948117   C   V   Yes   NS, NC   O53863   metabolism       442   949049   C   G   948292   T   S   948192   T   S   Yes   NS, NC   O53863   metabolism       443   951897   A   Null   951140   C   Null   951040   C   null   No   nc, NULL   Null   —       444   953517   C   Null   952760   G   Null   952660   G   null   No   nc, NULL   Null   —       445   958717   A   L   957961   G   L   957861   G   L   Yes   S, NULL   Null   —       446   959147   A   T   958391   G   A   958291   G   A   Yes   NS, NC   O53872   enzyme activity       447   960133   G   A   959377   A   V   959277   A   V   Yes   NS, C   O53873   nucleic acid binding                                                           activity       448   961068   G   S   960365   A   L   960371   A   L   Yes   NS, NC   O53874   —       449   967989   T   S   967527   C   G   967533   C   G   Yes   NS, NC   O53882   —       450   970372   A   L   969904   G   L   969919   G   L   Yes   S, NULL   Null   —       451   972368   A   G   971900   G   G   971915   G   G   Yes   S, NULL   Null   —       452   974604   G   L   974136   A   L   974150   A   L   Yes   S, NULL   Null   —       453   976327   C   G   975859   T   D   975873   T   D   Yes   NS, NC   Q10564   integral to membrane       454   997447   G   A   996980   A   A   996994   A   A   Yes   S, NULL   Null   —       455   998183   C   Null   997716   G   Null   997730   G   null   No   nc, NULL   Null   —       456   1001197   G   A   1000730   A   T   1000744   A   T   Yes   NS, NC   Q10530   enzyme activity       457   1009407   C   Null   1008940   T   Null   1008954   T   null   No   nc, NULL   Null   —       458   1010182   T   G   1009715   C   G   1009729   C   G   Yes   S, NULL   Null   —       459   1010422   A   L   1009955   G   L   1009969   G   L   Yes   S, NULL   Null   —       460   1011566   T   L   1011098   C   P   1011113   C   P   Yes   NS, NC   O05900   —       461   1015281   G   Q   1014813   T   H   1014828   T   H   Yes   NS, NC   O05901   —       462   1018494   A   L   1018026   G   P   1018041   G   P   Yes   NS, NC   O05905   —       463   1024812   G   G   1024344   A   S   1024359   A   S   Yes   NS, NC   O05910   —       464   1026536   T   E   1026068   G   D   1026083   G   D   Yes   NS, C   O05912   —       465   1027911   C   V   1027443   G   V   1027458   G   V   Yes   S, NULL   Null   —       466   1030402   G   R   1029934   A   R   1029949   A   R   Yes   S, NULL   Null   —       467   1034703   G   L   1034236   A   L   1034251   A   L   Yes   S, NULL   Null   —       468   1041172   C   A   1040704   A   S   1040719   A   S   Yes   NS, NC   O05870   transporter activity       469   1043636   C   A   1043167   T   V   1043182   T   V   Yes   NS, C   P15712   transporter activity       470   1048294   T   L   1047825   C   L   1047840   C   L   Yes   S, NULL   Null   —       471   1054603   T   T   1054134   C   T   1054149   C   T   Yes   S, NULL   Null   —       472   1055251   G   G   1054782   C   R   1054797   C   R   Yes   NS, NC   P71564   metabolism       473   1063212   C   A   1062743   T   V   1062758   T   V   Yes   NS, C   P71559   enzyme activity       474   1064232   A   K   1063763   G   R   1063778   G   R   Yes   NS, C   P71558   enzyme activity       475   1077356   T   H   1076915   C   R   1076930   C   R   Yes   NS, NC   P71545   —       476   1077719   C   G   1077278   A   W   1077293   A   W   Yes   NS, NC   P71544   —       477   1080631   A   N   1080190   G   D   1080205   G   D   Yes   NS, NC   P77894   magnesium ion binding                                                           activity       478   1083482   A   H   1083041   C   Q   1083056   C   Q   Yes   NS, NC   P71539   acyl-CoA                                                           dehydrogenase activity       479   1085532   A   F   1085091   T   I   1085106   T   I   Yes   NS, NC   P71538   ATP binding activity       480   1096095   T   T   1095642   C   A   1095671   C   A   Yes   NS, NC   O53893   —       481   1096129   G   G   1095676   A   G   1095705   A   G   Yes   S, NULL   Null   —       482   1096774   T   Q   1096321   G   H   1096362   G   H   Yes   NS, NC   O53893   —       483   1097474   A   S   1097021   G   G   1097062   G   G   Yes   NS, NC   O53894   two-component                                                           response regulator                                                           activity       484   1098974   A   H   1098521   T   L   1098562   T   L   Yes   NS, NC   O53895   two-component sensor                                                           molecule activity       485   1102935   T   L   1102482   G   V   1102523   G   V   Yes   NS, C   O53899   nucleotide binding                                                           activity       486   1103991   T   G   1103538   C   G   1103579   C   G   Yes   S, NULL   Null   —       487   1104263   A   *   1103810   G   W   1103851   G   W   Yes   NS, TP   O53900   membrane       488   1105141   G   V   1104688   T   F   1104729   T   F   Yes   NS, NC   O53900   membrane       489   1105524   G   G   1105071   A   G   1105112   A   G   Yes   S, NULL   Null   —       490   1105735   A   I   1105282   G   V   1105323   G   V   Yes   NS, C   O86370   —       491   1105969   G   D   1105516   T   Y   1105557   T   Y   Yes   NS, NC   O86370   —       492   1108391   C   A   1107938   A   S   1107979   A   S   Yes   NS, NC   O05573   —       493   1109614   G   I   1109161   C   M   1109202   C   M   Yes   NS, NC   O05575   enzyme activity       494   1111407   G   G   1110954   T   C   1110995   T   C   Yes   NS, NC   O05577   Mo-molybdopterin                                                           cofactor biosynthesis       495   1113109   G   G   1112656   A   D   1112697   A   D   Yes   NS, NC   O05579   —       496   1113741   C   Q   1113288   G   E   1113329   G   E   Yes   NS, NC   O05579   —       497   1120048   G   L   1119595   C   V   1119635   C   V   Yes   NS, C   O05586   mannosyltransferase                                                           activity       498   1124048   G   S   1123595   A   L   1123641   A   L   Yes   NS, NC   O05591   biosynthesis       499   1124238   G   S   1123785   A   N   1123831   A   S   Yes   NS, C   O05592   —       500   1125767   T   S   1125314   C   P   1125360   C   P   Yes   NS, NC   O05592   —       501   1129386   A   E   1128933   G   G   1128979   G   G   Yes   NS, NC   O05594   —       502   1129611   T   V   1129158   C   A   1129204   C   A   Yes   NS, C   O05594   —       503   1131752   A   N   1131298   G   S   1131344   G   null   Yes   NS, C   O05597   —       504   1137772   G   Q   1137323   C   E   1137369   C   E   Yes   NS, NC   P96382   UDP-N-                                                           acetylglucosamine                                                           pyrophosphorylase                                                           activity       505   1138029   C   G   1137580   T   E   1137626   T   E   Yes   NS, NC   P96382   UDP-N-                                                           acetylglucosamine                                                           pyrophosphorylase                                                           activity       506   1139461   T   L   1139012   C   L   1139058   C   L   Yes   S, NULL   Null   —       507   1144279   C   P   1143830   A   T   1143876   A   T   Yes   NS, NC   P96378   —       508   1145032   G   G   1144583   A   R   1144629   A   R   Yes   NS, NC   P96377   phosphopyruvate                                                           hydratase complex       509   1148706   G   Null   1148257   A   Null   1148303   A   null   Yes   nc, NULL   Null   —       510   1149575   T   L   1149126   C   L   1149172   C   L   Yes   S, NULL   Null   —       511   1151250   T   D   1150801   C   G   1150847   C   G   Yes   NS, NC   P96372   two-component sensor                                                           molecule activity       512   1152153   T   Null   1151704   C   Null   1151750   C   null   Yes   nc, NULL   Null   —       513   1161217   A   L   1160768   T   Q   1160814   T   Q   Yes   NS, NC   P96364   —       514   1164196   A   Null   1163747   G   Null   1163793   G   null   Yes   nc, NULL   Null   —       515   1164719   T   Null   1164270   C   Null   1164316   C   null   Yes   nc, NULL   Null   —       516   1165018   G   Null   1164569   A   Null   1164615   A   null   No   nc, NULL   Null   —       517   1165561   T   N   1165112   C   D   1165158   C   null   Yes   NS, NC   P96360   —       518   1166468   A   C   1166018   C   G   1166065   C   G   Yes   NS, NC   P96358   serine-type                                                           endopeptidase activity       519   1166960   T   T   1166510   C   A   1166557   C   A   Yes   NS, NC   P96358   serine-type                                                           endopeptidase activity       520   1168430   G   G   1167980   T   W   1168027   T   W   Yes   NS, NC   P96356   —       521   1169896   A   T   1169445   G   A   1169493   G   A   Yes   NS, NC   P96354   peroxidase activity       522   1170414   A   G   1169963   G   G   1170011   G   G   Yes   S, NULL   Null   —       523   1171297   A   Null   1170846   G   Null   1170894   G   null   Yes   nc, NULL   Null   —       524   1175230   A   Null   1174780   G   Null   1174828   G   null   No   nc, NULL   Null   —       525   1177201   C   Null   1176751   T   Null   1176799   T   null   Yes   nc, NULL   Null   —       526   1179589   G   Null   1179139   T   Null   1179187   T   null   No   nc, NULL   Null   —       527   1189705   T   M   1189243   C   V   1189291   C   V   Yes   NS, NC   O53415   —       528   1193177   C   W   1191815   A   L   1192055   A   L   Yes   NS, NC   O53416   —       529   1193221   C   E   1191859   T   E   1192099   T   E   Yes   S, NULL   Null   —       530   1199501   G   Null   1198139   A   Null   1198376   A   null   No   nc, NULL   Null   —       531   1199502   A   Null   1198140   C   Null   1198377   C   null   No   nc, NULL   Null   —       532   1199636   A   G   1198274   G   G   1198511   G   G   Yes   S, NULL   Null   —       533   1205184   C   T   1203822   T   I   1204059   T   I   Yes   NS, NC   O53426   —       534   1206868   A   N   1205506   G   N   1205743   G   N   Yes   S, NULL   Null   —       535   1212729   C   R   1211367   A   S   1211604   A   S   Yes   NS, NC   O53434   metabolism       536   1214512   T   G   1213168   C   G   1213326   C   null   Yes   S, NULL   Null   —       537   1221942   T   Null   1220568   G   Null   1220117   G   null   No   nc, NULL   Null   —       538   1226570   T   S   1225196   C   P   1224745   C   P   Yes   NS, NC   O53444   carbohydrate                                                           metabolism       539   1227449   A   L   1226075   G   P   1225624   G   P   Yes   NS, NC   O53445   —       540   1230847   G   D   1229473   T   E   1229022   T   E   Yes   NS, C   O53449   integral to membrane       541   1232149   A   I   1230776   G   T   1230325   G   T   Yes   NS, NC   O53450   DNA binding activity       542   1236028   A   D   1234655   G   D   1234205   G   D   Yes   S, NULL   Null   —       543   1236817   C   S   1235444   T   S   1234994   T   S   Yes   S, NULL   Null   —       544   1239854   A   I   1238481   G   V   1238031   G   V   Yes   NS, C   O53459   GTP binding activity       545   1241612   C   P   1240239   T   S   1239789   T   S   Yes   NS, NC   O06567   —       546   1244718   G   A   1243345   C   G   1242895   C   G   Yes   NS, C   O06572   guanylate cyclase                                                           activity       547   1245764   G   V   1244391   C   V   1243941   C   V   Yes   S, NULL   Null   —       548   1249753   G   G   1248380   A   S   1247930   A   null   Yes   NS, NC   O06577   —       549   1250307   C   P   1248934   G   P   1248483   G   P   Yes   S, NULL   Null   —       550   1251711   G   A   1250338   A   A   1249887   A   A   Yes   S, NULL   Null   —       551   1251728   G   P   1250355   T   T   1249904   T   T   Yes   NS, NC   O06579   ATP binding activity       552   1255933   G   G   1254560   A   D   1254109   A   D   Yes   NS, NC   O06582   —       553   1255953   C   L   1254580   T   F   1254129   T   F   Yes   NS, NC   O06582   —       554   1257383   T   R   1256010   G   R   1255559   G   R   Yes   S, NULL   Null   —       555   1259222   T   M   1257849   C   T   1257398   C   T   Yes   NS, NC   O06583   —       556   1261908   T   L   1260535   C   L   1260084   C   L   Yes   S, NULL   Null   —       557   1282061   C   G   1280687   T   D   1280179   T   D   Yes   NS, NC   O06551   methyltransferase                                                           activity       558   1282113   T   T   1280739   C   A   1280231   C   A   Yes   NS, NC   O06551   methyltransferase                                                           activity       559   1283143   C   P   1281769   T   S   1281261   T   S   Yes   NS, NC   O06553   —       560   1288484   C   Null   1287110   T   Null   1286600   T   null   No   nc, NULL   Null   —       561   1290071   C   L   1288697   G   V   1288187   G   V   Yes   NS, C   O06559   electron transport       562   1291161   G   G   1289787   A   D   1289277   A   D   Yes   NS, NC   O06559   electron transport       563   1295376   T   V   1294002   C   A   1293492   C   A   Yes   NS, C   O06562   electron transport       564   1295770   T   D   1294396   C   D   1293886   C   D   Yes   S, NULL   Null   —       565   1303656   G   H   1302281   T   Q   1301771   T   Q   Yes   NS, NC   O50428   —       566   1304272   G   Null   1302897   A   Null   1302387   A   null   No   nc, NULL   Null   —       567   1307530   C   S   1306279   A   I   1305769   A   I   Yes   NS, NC   O50431   electron transport       568   1309207   T   N   1307956   G   T   1307446   G   T   Yes   NS, C   O50431   electron transport       569   1311565   T   V   1310314   C   A   1309804   C   A   Yes   NS, C   O50434   transaminase activity       570   1318177   C   A   1316925   A   D   1316414   A   D   Yes   NS, NC   O50437   alcohol dehydrogenase                                                           activity       571   1325815   A   R   1324563   G   R   1324052   G   R   Yes   S, NULL   Null   —       572   1335064   T   L   1333812   C   L   1333301   C   L   Yes   S, NULL   Null   —       573   1340081   C   Null   1338829   A   Null   1338318   A   null   Yes   nc, NULL   Null   —       574   1341302   T   L   1340050   G   R   1339539   G   R   Yes   NS, NC   O05298   —       575   1341343   G   V   1340091   A   M   1339580   A   M   Yes   NS, NC   O05298   —       576   1341420   T   A   1340168   C   A   1339657   C   A   Yes   S, NULL   Null   —       577   1341887   T   Null   1340638   C   Null   1340127   C   null   No   nc, NULL   Null   —       578   1341914   G   S   1340665   A   S   1340154   A   S   Yes   S, NULL   Null   —       579   1342025   C   I   1340776   T   I   1340265   T   I   Yes   S, NULL   Null   —       580   1342028   G   S   1340779   C   S   1340268   C   S   Yes   S, NULL   Null   —       581   1342031   C   G   1340782   T   G   1340271   T   G   Yes   S, NULL   Null   —       582   1342077   A   T   1340828   G   A   1340317   G   A   Yes   NS, NC   O05299   —       583   1342287   A   D   1341038   C   A   1340527   C   A   Yes   NS, NC   O05300   —       584   1342456   T   A   1341207   C   A   1340696   C   A   Yes   S, NULL   Null   —       585   1343724   A   A   1342475   G   A   1341964   G   A   Yes   S, NULL   Null   —       586   1345988   G   Y   1344739   A   Y   1344228   A   Y   Yes   S, NULL   Null   —       587   1348420   T   L   1347171   C   L   1346660   C   L   Yes   S, NULL   Null   —       588   1352419   G   Null   1351170   A   Null   1350659   A   null   No   nc, NULL   Null   —       589   1356596   T   I   1355347   C   V   1354836   C   V   Yes   NS, C   O05313   biosynthesis       590   1357184   T   F   1355935   C   F   1355424   C   F   Yes   S, NULL   Null   —       591   1360182   A   S   1358938   C   A   1358427   C   A   Yes   NS, NC   O05316   DNA binding activity       592   1362617   T   T   1361373   C   A   1360862   C   A   Yes   NS, NC   O05318   —       593   1367980   C   L   1366734   T   F   1366224   T   F   Yes   NS, NC   O06291   serine-type                                                           endopeptidase activity       594   1368452   A   N   1367206   G   S   1366696   G   S   Yes   NS, C   O06291   serine-type                                                           endopeptidase activity       595   1368728   G   G   1367482   T   W   1366972   T   W   Yes   NS, NC   O33220   protein targeting       596   1370191   G   A   1368945   A   V   1368435   A   V   Yes   NS, C   O33222   —       597   1372850   C   Null   1371604   A   Null   1371094   A   null   Yes   nc, NULL   Null   —       598   1375153   G   P   1373907   A   S   1373397   A   S   Yes   NS, NC   O86313   transcription factor                                                           activity       599   1377868   T   D   1376622   C   G   1376112   C   G   Yes   NS, NC   O86316   —       600   1377935   C   D   1376689   T   N   1376179   T   N   Yes   NS, NC   O86316   —       601   1378384   G   E   1377138   A   E   1376628   A   E   Yes   S, NULL   Null   —       602   1383703   C   R   1382457   T   H   1381947   T   H   Yes   NS, NC   O50455   cobalt ion transport       603   1388166   T   G   1386920   C   G   1386410   C   G   Yes   S, NULL   Null   —       604   1388824   A   K   1387578   C   Q   1387068   C   Q   Yes   NS, NC   O50459   —       605   1391333   T   A   1390087   C   A   1389576   C   A   Yes   S, NULL   Null   —       606   1392007   T   M   1390761   C   V   1390250   C   V   Yes   NS, NC   O50463   metabolism       607   1394247   G   Null   1393001   T   Null   1392490   T   null   Yes   nc, NULL   Null   —       608   1394944   T   T   1393698   C   A   1393187   C   A   Yes   NS, NC   O50464   —       609   1396254   G   G   1395008   A   R   1394497   A   R   Yes   NS, NC   O50465   transporter activity       610   1398445   G   N   1397199   A   N   1396688   A   N   Yes   S, NULL   Null   —       611   1401640   G   V   1400394   A   M   1399883   A   M   Yes   NS, NC   Q11039   nucleic acid binding                                                           activity       612   1408298   C   R   1410060   G   P   1409548   G   P   Yes   NS, NC   Q11066   —       613   1410739   T   C   1412501   C   R   1411989   C   R   Yes   NS, NC   Q11055   guanylate cyclase                                                           activity       614   1412796   T   R   1414558   C   R   1414046   C   R   Yes   S, NULL   Null   —       615   1412800   T   N   1414562   A   I   1414050   A   I   Yes   NS, NC   Q11053   protein kinase activity       616   1412889   T   P   1414651   C   P   1414139   C   P   Yes   S, NULL   Null   —       617   1413243   G   A   1415095   C   A   1414583   C   A   Yes   S, NULL   Null   —       618   1415700   C   Null   1417552   G   Null   1417040   G   null   Yes   nc, NULL   Null   —       619   1417495   T   T   1419347   C   A   1418835   C   A   Yes   NS, NC   Q11049   membrane       620   1421972   T   A   1423824   C   A   1423312   C   A   Yes   S, NULL   Null   —       621   1422845   C   P   1424697   T   L   1424185   T   L   Yes   NS, NC   Q11045   membrane       622   1423465   A   Null   1425317   G   Null   1424805   G   null   No   nc, NULL   Null   —       623   1423787   A   S   1425639   T   T   1425127   T   T   Yes   NS, C   Q11043   hydrolase activity       624   1425622   T   F   1427474   C   F   1426962   C   F   Yes   S, NULL   Null   —       625   1435584   A   R   1437436   C   R   1436924   C   R   Yes   S, NULL   Null   —       626   1437785   T   L   1439637   G   V   1439125   G   V   Yes   NS, C   Q10600   sulfate assimilation       627   1438084   T   R   1439936   C   R   1439424   C   R   Yes   S, NULL   Null   —       628   1440727   G   Null   1442732   C   Null   1442220   C   null   No   nc, NULL   Null   —       629   1452860   T   N   1454809   C   N   1454352   C   N   Yes   S, NULL   Null   —       630   1456125   G   G   1458074   T   G   1457617   T   G   Yes   S, NULL   Null   —       631   1456193   A   Q   1458142   C   P   1457685   C   P   Yes   NS, NC   Q10618   molecular_function                                                           unknown       632   1457413   G   G   1459362   T   V   1458905   T   V   Yes   NS, C   Q10606   magnesium ion binding                                                           activity       633   1458715   T   V   1460664   C   V   1460207   C   V   Yes   S, NULL   Null   —       634   1460269   C   V   1462218   G   V   1461761   G   V   Yes   S, NULL   Null   —       635   1465744   T   V   1467693   C   A   1467236   C   A   Yes   NS, C   Q10620   integral to membrane       636   1465784   A   G   1467733   G   G   1467276   G   G   Yes   S, NULL   Null   —       637   1469253   T   F   1471215   C   F   1470758   C   F   Yes   S, NULL   Null   —       638   1476347   T   L   1478310   C   L   1477853   C   L   Yes   S, NULL   Null   —       639   1476918   T   *   1478881   C   W   1478424   C   W   Yes   NS, TP   Q10630   DNA binding activity       640   1477120   C   V   1479083   T   I   1478626   T   I   Yes   NS, C   Q10630   DNA binding activity       641   1487043   C   A   1489006   T   T   1490222   T   T   Yes   NS, NC   Q10637   —       642   1488940   G   P   1490903   A   S   1492119   A   S   Yes   NS, NC   Q10625       643   1488946   A   S   1490909   G   P   1492125   G   P   Yes   NS, NC   Q10625       644   1490229   C   G   1492192   T   D   1493408   T   D   Yes   NS, NC   Q10625       645   1490640   T   A   1492603   C   A   1493819   C   A   Yes   S, NULL   Null   —       646   1494193   G   G   1496156   A   D   1497372   A   D   Yes   NS, NC   Q10639   enzyme activity       647   1494324   T   F   1496287   G   V   1497503   G   V   Yes   NS, NC   Q10639   enzyme activity       648   1494999   T   S   1496962   G   A   1498178   G   A   Yes   NS, NC   Q10639   enzyme activity       649   1497326   T   G   1499289   C   G   1500505   C   G   Yes   S, NULL   Null   —       650   1497523   T   K   1499486   C   E   1500702   C   E   Yes   NS, NC   Q10641   —       651   1499260   G   R   1501223   T   R   1502439   T   R   Yes   S, NULL   Null   —       652   1500014   A   T   1501977   G   T   1503193   G   T   Yes   S, NULL   Null   —       653   1503229   C   G   1505192   T   G   1506408   T   G   Yes   S, NULL   Null   —       654   1504008   A   R   1505971   G   R   1507187   G   R   Yes   S, NULL   Null   —       655   1505078   A   S   1507041   G   G   1508257   G   G   Yes   NS, NC   Q10628   tRNA binding activity       656   1506717   G   A   1508680   T   E   1509896   T   E   Yes   NS, NC   Q11013   integral to membrane       657   1521210   C   A   1523173   A   A   1524390   A   A   Yes   S, NULL   Null   —       658   1521826   G   P   1523789   A   L   1525006   A   L   Yes   NS, NC   Q11025   enzyme activity       659   1524738   T   V   1526701   G   G   1527918   G   G   Yes   NS, C   Q11028   DNA binding activity       660   1525971   C   A   1527934   A   D   1529151   A   D   Yes   NS, NC   Q11028   DNA binding activity       661   1528766   A   R   1530729   G   G   1531946   G   G   Yes   NS, NC   Q11029   guanylate cyclase                                                           activity       662   1530691   T   A   1532654   G   A   1533871   G   A   Yes   S, NULL   Null   —       663   1530694   T   P   1532657   C   P   1533874   C   P   Yes   S, NULL   Null   —       664   1530695   G   P   1532658   T   P   1533875   T   P   Yes   S, NULL   Null   —       665   1530763   T   S   1532726   C   S   1533943   C   S   Yes   S, NULL   Null   —       666   1530890   T   N   1532853   C   S   1534070   C   S   Yes   NS, C   Q11031   —       667   1530894   T   T   1532857   C   A   1534074   C   A   Yes   NS, NC   Q11031   —       668   1530957   T   I   1532920   G   L   1534137   G   L   Yes   NS, C   Q11031   —       669   1531501   C   G   1533464   T   G   1534681   T   G   Yes   S, NULL   Null   —       670   1531505   A   V   1533468   G   V   1534685   G   V   Yes   S, NULL   Null   —       671   1531506   C   V   1533469   T   V   1534686   T   V   Yes   S, NULL   Null   —       672   1531581   G   Q   1533544   T   K   1534761   T   K   Yes   NS, NC   Q11031   —       673   1531582   A   A   1533545   C   A   1534762   C   A   Yes   S, NULL   Null   —       674   1531585   C   A   1533548   G   A   1534765   G   A   Yes   S, NULL   Null   —       675   1532338   C   G   1534301   A   V   1535518   A   V   Yes   NS, C   Q11032   integral to membrane       676   1532964   T   N   1534927   G   T   1536144   G   T   Yes   NS, C   Q11033   integral to membrane       677   1534974   T   T   1536937   C   A   1538155   C   A   Yes   NS, NC   Q11034   two-component sensor                                                           molecule activity       678   1535961   T   K   1537924   C   E   1539142   C   E   Yes   NS, NC   Q11035   —       679   1537543   A   Null   1539506   G   Null   1540724   G   null   No   nc, NULL   Null   —       680   1538176   C   V   1540139   T   I   1541357   T   I   Yes   NS, C   Q11037   —       681   1540933   T   C   1544253   C   C   1544113   C   C   Yes   S, NULL   Null   —       682   1543382   T   A   1546701   C   A   1546561   C   A   Yes   S, NULL   Null   —       683   1544766   A   R   1548085   G   G   1547945   G   G   Yes   NS, NC   P71803   —       684   1544828   A   P   1548147   G   P   1548007   G   P   Yes   S, NULL   Null   —       685   1545475   C   P   1548794   G   R   1548654   G   R   Yes   NS, NC   P71803   —       686   1546533   C   P   1549852   G   R   1549712   G   R   Yes   NS, NC   P71804   —       687   1549309   T   H   1552628   C   R   1552488   C   R   Yes   NS, NC   P71806   —       688   1551431   T   F   1554750   G   V   1554610   G   V   Yes   NS, NC   P71809   dihydroorotase activity       689   1553002   G   G   1556321   C   A   1556181   C   A   Yes   NS, C   P71811   enzyme activity       690   1556241   A   E   1559560   C   A   1559420   C   A   Yes   NS, NC   Not   —                                                       annotated       691   1556275   T   H   1559594   C   H   1559454   C   H   Yes   S, NULL   Null   —       692   1558090   A   Null   1561409   G   Null   1561269   G   null   No   nc, NULL   Null   —       693   1558582   C   S   1561901   A   S   1561761   A   S   Yes   S, NULL   Null   —       694   1558728   C   A   1562047   T   V   1561907   T   V   Yes   NS, C   P71657   —       695   1563681   G   A   1567000   A   T   1566860   A   T   Yes   NS, NC   P77899   magnesium ion binding                                                           activity       696   1569266   T   H   1572957   C   R   1572817   C   null   Yes   NS, NC   P71664   integral to membrane       697   1570275   T   Null   1573966   C   Null   1573825   C   null   No   nc, NULL   Null   —       698   1570513   C   G   1574204   T   D   1574063   T   D   Yes   NS, NC   P71665   —       699   1578358   C   Null   1582049   T   Null   1581905   T   null   No   nc, NULL   Null   —       700   1580686   C   L   1584377   A   I   1584233   A   I   Yes   NS, C   P71675   RNA binding activity       701   1581590   C   N   1585281   A   K   1585137   A   K   Yes   NS, NC   P71677   enzyme activity       702   1581711   A   T   1585402   G   A   1585258   G   A   Yes   NS, NC   P71677   enzyme activity       703   1585618   G   Null   1589309   T   Null   1589165   T   null   No   nc, NULL   Null   —       704   1589763   T   Null   1593454   C   Null   1593310   C   null   No   nc, NULL   Null   —       705   1593041   T   R   1596732   C   R   1596588   C   R   Yes   S, NULL   Null   —       706   1593444   T   V   1597135   C   A   1596991   C   A   Yes   NS, C   P71691   —       707   1596992   T   L   1600683   C   P   1600539   C   P   Yes   NS, NC   P71694   molecular_function                                                           unknown       708   1604583   C   T   1608274   A   N   1608132   A   N   Yes   NS, C   O06827   —       709   1605752   C   Q   1609443   A   K   1609301   A   K   Yes   NS, NC   O06827   —       710   1607590   C   Null   1611281   T   Null   1611139   T   null   No   nc, NULL   Null   —       711   1609080   T   T   1612750   C   A   1612635   C   A   Yes   NS, NC   O06823   —       712   1614744   A   G   1618414   G   G   1618299   G   null   Yes   S, NULL   Null   —       713   1614952   T   N   1618622   G   T   1618507   G   null   Yes   NS, C   O06818   structural molecule                                                           activity       714   1615306   C   G   1618976   T   D   1618860   T   null   Yes   NS, NC   O06818   structural molecule                                                           activity       715   1627846   G   G   1631524   A   G   1631407   A   G   Yes   S, NULL   Null   —       716   1628460   G   H   1632138   T   N   1632021   T   N   Yes   NS, NC   O06810   —       717   1629691   G   N   1633342   A   N   1633252   A   N   Yes   S, NULL   Null   —       718   1631814   A   T   1635228   G   A   1635345   G   A   Yes   NS, NC   O06809   heme biosynthesis       719   1636164   G   L   1639416   A   L   1639521   A   L   Yes   S, NULL   Null   —       720   1636389   C   R   1639641   T   R   1639746   T   R   Yes   S, NULL   Null   —       721   1637188   T   G   1640440   C   G   1640545   C   G   Yes   S, NULL   Null   —       722   1643728   T   V   1646980   C   A   1647138   C   A   Yes   NS, C   O53151   transcription factor                                                           activity       723   1643863   C   G   1647115   T   G   1647273   T   G   Yes   S, NULL   Null   —       724   1656740   T   S   1659992   C   P   1660150   C   P   Yes   NS, NC   O53163   enzyme activity       725   1657398   T   Null   1660650   G   Null   1660808   G   null   No   nc, NULL   Null   —       726   1657399   T   Null   1660651   A   Null   1660809   A   null   No   nc, NULL   Null   —       727   1658616   A   Q   1661868   G   Q   1662026   G   Q   Yes   S, NULL   Null   —       728   1659304   C   P   1662556   T   Null   1662714   T   S   Yes   nc, NULL   Null   —       729   1659465   C   A   1662717   G   A   1662875   G   A   Yes   S, NULL   Null   —       730   1668404   T   R   1671656   C   R   1671814   C   R   Yes   S, NULL   Null   —       731   1669135   C   Null   1672387   T   Null   1672545   T   null   No   nc, NULL   Null   —       732   1678674   T   V   1681926   C   V   1682084   C   V   Yes   S, NULL   Null   —       733   1681725   C   S   1684977   T   S   1685135   T   S   Yes   S, NULL   Null   —       734   1683015   T   Null   1686267   C   Null   1686425   C   null   No   nc, NULL   Null   —       735   1685046   C   F   1688298   T   F   1688456   T   F   Yes   S, NULL   Null   —       736   1687091   G   Null   1690343   A   Null   1690501   A   null   Yes   S, NULL   Null   —       737   1690478   T   C   1693731   C   C   1693889   C   C   Yes   S, NULL   Null   —       738   1690944   T   K   1694197   C   E   1694355   C   null   Yes   NS, NC   CAB02017   —       739   1691292   C   E   1694545   A   *   1694703   A   null   Yes   NS, TP   CAB02018   —       740   1692419   A   Y   1695672   G   Y   1695830   G   Y   Yes   S, NULL   Null   —       741   1694454   A   R   1710439   C   S   1710596   C   S   Yes   NS, NC   Q50590   integral to membrane       742   1694605   C   L   1710590   A   M   1710747   A   M   Yes   NS, NC   Q50590   integral to membrane       743   1696535   T   I   1712520   G   S   1712677   G   S   Yes   NS, NC   Q50586   enzyme activity       744   1698303   T   *   1714288   G   S   1714445   G   S   Yes   NS, TP   Q50585   membrane       745   1698786   T   N   1714771   C   S   1714928   C   S   Yes   NS, C   Q50585   membrane       746   1700485   G   P   1716470   A   S   1716627   A   S   Yes   NS, NC   Q50585   membrane       747   1701016   C   A   1717001   T   T   1717158   T   T   Yes   NS, NC   Q50585   membrane       748   1703404   T   F   1719389   C   F   1719546   C   F   Yes   S, NULL   Null   —       749   1708108   G   L   1724093   A   F   1724250   A   null   Yes   NS, NC   O53901   enzyme activity       750   1710829   T   T   1726814   G   P   1726970   G   null   Yes   NS, NC   O53901   enzyme activity       751   1712677   T   Null   1728662   C   Null   1728818   C   null   Yes   nc, NULL   Null   —       752   1715811   A   A   1731796   G   A   1731952   G   A   Yes   S, NULL   Null   —       753   1723307   G   A   1739292   C   P   1739447   C   P   Yes   NS, NC   Q10765   tRNA ligase activity       754   1734934   A   A   1750919   C   A   1751074   C   A   Yes   S, NULL   Null   —       755   1737144   G   A   1753129   A   V   1753284   A   V   Yes   NS, C   Q10778   integral to membrane       756   1737486   C   Null   1753471   G   Null   1753626   G   null   Yes   nc, NULL   Null   —       757   1738210   A   G   1754193   G   G   1754349   G   G   Yes   S, NULL   Null   —       758   1738587   C   S   1754570   T   L   1754726   T   L   Yes   NS, NC   Q10776   enzyme activity       759   1744942   C   T   1760921   T   T   1761077   T   T   Yes   S, NULL   Null   —       760   1752792   T   T   1766618   C   A   1766774   C   A   Yes   NS, NC   Q10769   hydrolase activity       761   1760533   A   Null   1775165   G   Null   1775321   G   null   No   nc, NULL   Null   —       762   1779600   A   A   1794232   G   A   1785141   G   A   Yes   S, NULL   Null   —       763   1782943   G   D   1797575   A   N   1788484   A   N   Yes   NS, NC   O06594   nicotinate-nucleotide                                                           pyrophosphorylase                                                           (carboxylating) activity       764   1785887   G   Q   1800519   A   Q   1791428   A   Q   Yes   S, NULL   Null   —       765   1789614   A   E   1804246   G   E   1795155   G   E   Yes   S, NULL   Null   —       766   1789681   C   H   1804313   T   Y   1795222   T   Y   Yes   NS, C   O53907   inositol/                                                           phosphatidylinositol                                                           phosphatase                                                           activity       767   1790156   T   L   1804788   C   P   1795697   C   P   Yes   NS, NC   O53907   inositol/                                                           phosphatidylinositol                                                           phosphatase                                                           activity       768   1790580   T   L   1805212   C   P   1796121   C   P   Yes   NS, NC   O53908   histidine biosynthesis       769   1798626   C   V   1813258   T   V   1804167   T   V   Yes   S, NULL   Null   —       770   1802214   T   D   1816846   G   E   1807755   G   E   Yes   NS, C   O06134   magnesium ion binding                                                           activity       771   1808750   C   T   1823382   G   T   1814291   G   T   Yes   S, NULL   Null   —       772   1811420   C   A   1826052   T   T   1816961   T   T   Yes   NS, NC   O06141   —       773   1813171   T   V   1827803   C   V   1818712   C   V   Yes   S, NULL   Null   —       774   1813366   A   Null   1827998   G   Null   1818907   G   null   No   nc, NULL   Null   —       775   1813755   T   R   1828387   C   R   1819296   C   R   Yes   S, NULL   Null   —       776   1815661   A   F   1830293   G   F   1821202   G   F   Yes   S, NULL   Null   —       777   1820225   A   T   1834857   G   A   1825766   G   A   Yes   NS, NC   O06147   RNA binding activity       778   1822223   T   Null   1836855   G   Null   1827764   G   null   No   nc, NULL   Null   —       779   1824626   G   L   1839258   T   L   1830167   T   L   Yes   S, NULL   Null   —       780   1825125   C   R   1839757   G   G   1830666   G   G   Yes   NS, NC   O06151   transporter activity       781   1828921   A   N   1843553   G   N   1834462   G   N   Yes   S, NULL   Null   —       782   1834571   C   G   1849203   T   D   1840112   T   D   Yes   NS, NC   P94974   magnesium ion binding                                                           activity       783   1834975   C   R   1849607   T   R   1840516   T   R   Yes   S, NULL   Null   —       784   1844924   A   D   1859557   C   A   1850466   C   A   Yes   NS, NC   P94984   magnesium ion binding                                                           activity       785   1845757   T   V   1860390   C   A   1851299   C   A   Yes   NS, C   P94985   tRNA binding activity       786   1850233   A   V   1864866   G   A   1855775   G   A   Yes   NS, C   P94986   —       787   1858345   G   R   1872957   A   R   1863865   A   R   Yes   S, NULL   Null   —       788   1862697   T   W   1877309   C   R   1868217   C   R   Yes   NS, NC   P94996   enzyme activity       789   1863620   A   T   1878232   G   T   1869140   G   T   Yes   S, NULL   Null   —       790   1864215   C   P   1878827   T   S   1869735   T   S   Yes   NS, NC   P94996   enzyme activity       791   1867321   T   Y   1881933   G   D   1872841   G   D   Yes   NS, NC   O65933   enzyme activity       792   1867566   T   A   1882178   C   A   1873086   C   A   Yes   S, NULL   Null   —       793   1869512   T   V   1884124   C   A   1875032   C   A   Yes   NS, C   O65933   enzyme activity       794   1869897   A   V   1884509   G   V   1875417   G   V   Yes   S, NULL   Null   —       795   1870867   G   G   1885479   C   R   1876387   C   R   Yes   NS, NC   O65933   enzyme activity       796   1871495   G   C   1886107   A   Y   1877015   A   Y   Yes   NS, NC   O65933   enzyme activity       797   1873514   A   T   1888126   G   A   1879034   G   A   Yes   NS, NC   O06586   enzyme activity       798   1874459   C   P   1889071   G   A   1879979   G   A   Yes   NS, NC   O06586   enzyme activity       799   1878859   A   T   1893471   G   T   1884379   G   T   Yes   S, NULL   Null   —       800   1885417   T   Null   1900019   C   Null   1890823   C   null   Yes   nc, NULL   Null   —       801   1886196   G   A   1900798   A   V   1891602   A   V   Yes   NS, C   O53922   transcription factor                                                           activity       802   1888569   T   I   1903171   C   I   1893975   C   I   Yes   S, NULL   Null   —       803   1890513   G   G   1905115   C   A   1895919   C   A   Yes   NS, C   O33182   —       804   1891732   G   Null   1906334   A   Null   1897138   A   null   No   nc, NULL   Null   —       805   1897364   A   F   1912022   C   V   1902826   C   V   Yes   NS, NC   O33188   drug transporter activity       806   1897922   A   A   1912580   G   A   1903384   G   A   Yes   S, NULL   Null   —       807   1899910   C   A   1914568   A   A   1905372   A   A   Yes   S, NULL   Null   —       808   1905462   T   P   1920118   G   P   1910922   G   P   Yes   S, NULL   Null   —       809   1910301   C   G   1924957   T   G   1915761   T   G   Yes   S, NULL   Null   —       810   1911052   G   L   1925708   C   F   1916512   C   F   Yes   NS, NC   O33199   —       811   1911527   A   T   1926183   G   A   1916987   G   A   Yes   NS, NC   O33199   —       812   1915691   T   A   1930348   C   A   1921152   C   A   Yes   S, NULL   Null   —       813   1916811   A   Null   1931468   G   Null   1922272   G   null   No   nc, NULL   Null   —       814   1917059   C   V   1931716   G   L   1922520   G   L   Yes   NS, C   O33204   —       815   1921036   G   A   1935693   T   S   1926497   T   S   Yes   NS, NC   O33206   sulfate porter activity       816   1921535   A   Q   1936192   G   R   1926996   G   R   Yes   NS, NC   O33206   sulfate porter activity       817   1921866   A   T   1936523   G   A   1927327   G   null   Yes   NS, NC   O33207   —       818   1928563   A   Null   1943220   G   Null   1934024   G   null   Yes   S, NULL   Null   —       819   1933291   A   M   1947949   G   V   1938753   G   V   Yes   NS, NC   P71980   —       820   1934421   T   R   1949079   C   R   1939883   C   R   Yes   S, NULL   Null   —       821   1937104   A   Null   1951762   G   Null   1942565   G   null   No   nc, NULL   Null   —       822   1937372   C   P   1952030   G   A   1942833   G   A   Yes   NS, NC   P71984   sugar porter activity       823   1938167   T   Y   1952825   C   H   1943628   C   H   Yes   NS, C   P71984   sugar porter activity       824   1941920   A   T   1956521   C   T   1947381   C   T   Yes   S, NULL   Null   —       825   1942743   C   Null   1957344   T   Null   1948204   T   null   Yes   nc, NULL   Null   —       826   1946179   C   A   1960780   T   T   1951640   T   A   Yes   NS, NC   P71992   —       827   1948447   C   R   1963048   T   R   1953908   T   R   Yes   S, NULL   Null   —       828   1949354   C   G   1963955   T   D   1954815   T   D   Yes   NS, NC   P71994   electron transport       829   1949427   G   H   1964028   C   D   1954888   C   D   Yes   NS, NC   P71994   electron transport       830   1950831   G   Null   1965432   A   Null   1956292   A   null   No   nc, NULL   Null   —       831   1953513   C   T   1968114   A   K   1958974   A   K   Yes   NS, NC   P71999   —       832   1953569   T   Null   1968170   G   Null   1959030   G   null   No   nc, NULL   Null   —       833   1954568   A   D   1969168   T   V   1960028   T   V   Yes   NS, NC   P72001   protein kinase activity       834   1956427   T   Q   1971027   C   R   1961887   C   R   Yes   NS, NC   O06787   —       835   1956859   T   Null   1971459   G   Null   1962319   G   null   Yes   S, NULL   Null   —       836   1957123   C   R   1971723   G   R   1962583   G   R   Yes   S, NULL   Null   —       837   1957247   G   S   1971847   A   F   1962707   A   F   Yes   NS, NC   P72002   isopentenyl-                                                           diphosphate delta-                                                           isomerase activity       838   1958508   A   T   1973108   G   A   1963968   G   A   Yes   NS, NC   P72003   protein kinase activity       839   1961358   T   S   1975958   G   S   1966818   G   S   Yes   S, NULL   Null   —       840   1965950   C   T   1980550   T   M   1971410   T   M   Yes   NS, NC   O65936   monooxygenase activity       841   1981202   G   G   1990359   A   G   1988183   A   null   Yes   S, NULL   Null   —       842   1982624   G   G   1991781   A   G   1989605   A   null   Yes   S, NULL   Null   —       843   1985405   T   T   1994564   C   T   1992387   C   T   Yes   S, NULL   Null   —       844   1989704   G   R   1999262   A   Null   1996686   A   null   Yes   nc, NULL   Null   —       845   1991672   C   H   2001230   A   N   1998654   A   null   Yes   NS, NC   O06801   —       846   1993549   T   L   2003089   C   L   2000511   C   L   Yes   S, NULL   Null   —       847   1997652   A   F   2007192   G   F   2004614   G   F   Yes   S, NULL   Null   —       848   2001072   A   Null   2010612   G   Null   2008034   G   null   No   nc, NULL   Null   —       849   2002085   G   Q   2011625   C   H   2009047   C   H   Yes   NS, NC   O33180   monooxygenase activity       850   2002894   C   R   2012434   G   T   2009856   G   T   Yes   NS, NC   O33181   —       851   2004047   T   L   2013587   C   L   2011009   C   L   Yes   S, NULL   Null   —       852   2007749   C   R   2017289   T   R   2014711   T   R   Yes   S, NULL   Null   —       853   2008319   A   H   2017859   G   R   2015281   G   R   Yes   NS, NC   O53933   —       854   2009694   G   P   2019234   T   P   2016656   T   P   Yes   S, NULL   Null   —       855   2011784   G   A   2021324   A   A   2018746   A   A   Yes   S, NULL   Null   —       856   2012022   A   M   2021562   G   V   2018984   G   V   Yes   NS, NC   O53935   nucleotide binding                                                           activity       857   2017231   A   Null   2026774   G   Null   2024196   G   null   Yes   nc, NULL   Null   —       858   2018064   G   A   2027607   T   S   2025029   T   S   Yes   NS, NC   O53939   —       859   2019447   T   S   2028990   C   P   2026412   C   P   Yes   NS, NC   O53940   —       860   2019644   G   P   2029187   A   P   2026609   A   P   Yes   S, NULL   Null   —       861   2020481   T   P   2030024   C   P   2027446   C   P   Yes   S, NULL   Null   —       862   2020767   T   Null   2030310   C   Null   2027732   C   null   No   nc, NULL   Null   —       863   2020942   T   G   2030485   C   G   2027907   C   null   Yes   S, NULL   Null   —       864   2020943   C   Q   2030486   A   Q   2027908   A   null   Yes   S, NULL   Null   —       865   2020944   A   Q   2030487   T   Q   2027909   T   null   Yes   S, NULL   Null   —       866   2020976   C   Q   2030519   T   *   2027941   T   null   Yes   NS, TP   Not   —                                                       annotated       867   2021631   T   P   2031174   G   P   2028596   G   P   Yes   S, NULL   Null   —       868   2022570   G   Null   2032113   A   Null   2029535   A   null   No   nc, NULL   Null   —       869   2023460   G   A   2033003   A   T   2030425   A   T   Yes   NS, NC   O53944   —       870   2023476   A   D   2033019   G   G   2030441   G   G   Yes   NS, NC   O53944   —       871   2030339   G   W   2039882   T   C   2037304   T   C   Yes   NS, NC   O53949   —       872   2030664   G   V   2040207   T   F   2037629   T   F   Yes   NS, NC   O53949   —       873   2031415   C   A   2040958   T   V   2038380   T   V   Yes   NS, C   O53949   —       874   2037036   A   *   2046579   G   Q   2044001   G   Q   Yes   NS, TP   O53952   —       875   2037314   C   Null   2046857   T   Null   2044279   T   null   Yes   nc, NULL   Null   —       876   2039950   T   P   2049493   C   P   2046915   C   P   Yes   S, NULL   Null   —       877   2040516   G   S   2050059   A   S   2047481   A   S   Yes   S, NULL   Null   —       878   2041277   C   A   2050820   G   G   2048242   G   G   Yes   NS, C   O53957   —       879   2042298   T   *   2051841   C   Q   2049263   C   Q   Yes   NS, TP   O53958   proton transport       880   2043142   C   S   2052685   G   *   2050107   G   *   Yes   NS, TP   O53958   proton transport       881   2044762   A   T   2054305   G   T   2051727   G   T   Yes   S, NULL   Null   —       882   2048737   G   K   2058280   A   K   2055702   A   K   Yes   S, NULL   Null   —       883   2052442   T   S   2061976   C   G   2059405   C   G   Yes   NS, NC   Q50615   integral to membrane       884   2053144   G   Null   2062678   A   Null   2060017   A   null   Yes   nc, NULL   Null   —       885   2053386   C   V   2062920   T   I   2060259   T   I   Yes   NS, C   Q50614   nucleotide binding                                                           activity       886   2054840   G   A   2064374   A   V   2061713   A   V   Yes   NS, C   Q50614   nucleotide binding                                                           activity       887   2055511   A   P   2065045   G   P   2062384   G   P   Yes   S, NULL   Null   —       888   2062654   C   A   2072188   A   E   2069527   A   E   Yes   NS, NC   Q50607   glycine cleavage                                                           system complex       889   2064683   T   C   2074217   C   R   2071556   C   R   Yes   NS, NC   Q50604   —       890   2065441   C   Y   2075087   T   Y   2072314   T   Y   Yes   S, NULL   Null   —       891   2066872   C   A   2076518   T   V   2073745   T   V   Yes   NS, C   Q50601   glycine cleavage                                                           system       892   2067570   G   A   2077216   A   T   2074443   A   T   Yes   NS, NC   Q50601   glycine cleavage                                                           system       893   2068670   T   V   2078316   C   V   2075543   C   V   Yes   S, NULL   Null   —       894   2070996   C   A   2080642   T   V   2077869   T   V   Yes   NS, C   Q50599   enzyme activity       895   2073217   T   H   2082863   C   R   2080091   C   R   Yes   NS, NC   Q50597   integral to membrane       896   2074580   A   C   2084226   G   R   2081454   G   R   Yes   NS, NC   Q50597   integral to membrane       897   2080993   G   S   2090774   A   L   2088002   A   L   Yes   NS, NC   Q50592   integral to membrane       898   2082905   A   G   2092686   G   G   2089914   G   G   Yes   S, NULL   Null   —       899   2083932   C   K   2093713   T   Null   2090941   T   null   Yes   nc, NULL   Null   —       900   2086536   A   Y   2096324   C   D   2093546   C   D   Yes   NS, NC   P95163   —       901   2087337   T   N   2097126   C   N   2094348   C   N   Yes   S, NULL   Null   —       902   2087353   C   L   2097142   G   V   2094364   G   V   Yes   NS, C   P95162   enzyme activity       903   2090002   T   L   2099791   A   M   2097013   A   M   Yes   NS, NC   P50050   nickel ion binding                                                           activity       904   2092402   A   W   2102191   G   R   2099413   G   R   Yes   NS, NC   P95160   electron transport       905   2094478   T   H   2104268   C   R   2101490   C   R   Yes   NS, NC   P95158   metabolism       906   2094633   T   A   2104423   C   A   2101645   C   A   Yes   S, NULL   Null   —       907   2097719   T   M   2107509   C   T   2104731   C   T   Yes   NS, NC   P95155   nucleotide binding                                                           activity       908   2099098   C   Null   2108888   A   Null   2106110   A   null   No   nc, NULL   Null   —       909   2099682   T   Null   2109472   C   Null   2106694   C   null   No   nc, NULL   Null   —       910   2100574   C   T   2110363   A   T   2107586   A   T   Yes   S, NULL   Null   —       911   2103397   C   Q   2113186   G   E   2110409   G   E   Yes   NS, NC   P95149   DNA binding activity       912   2110986   T   L   2120775   C   Null   2117998   C   null   Yes   nc, NULL   Null   —       913   2111005   A   L   2120794   T   *   2118017   T   *   Yes   NS, TP   P95145   base-excision repair       914   2112834   G   A   2122623   A   V   2119846   A   V   Yes   NS, C   P95143   electron transport       915   2113185   G   A   2122974   C   G   2120197   C   G   Yes   NS, C   P95143   electron transport       916   2113487   G   G   2123276   T   G   2120499   T   G   Yes   S, NULL   Null   —       917   2113686   A   N   2123475   G   D   2120698   G   D   Yes   NS, NC   O07756   —       918   2116072   T   Null   2125861   C   Null   2123084   C   null   No   nc, NULL   Null   —       919   2118582   G   T   2128370   A   T   2125593   A   T   Yes   S, NULL   Null   —       920   2119054   A   T   2128842   G   A   2126065   G   A   Yes   NS, NC   O07752   glutamate-ammonia                                                           ligase activity       921   2119491   A   A   2129279   C   A   2126502   C   A   Yes   S, NULL   Null   —       922   2120739   G   Null   2130527   A   Null   2127750   A   null   No   nc, NULL   Null   —       923   2128138   A   G   2137901   G   G   2135149   G   G   Yes   S, NULL   Null   —       924   2134872   A   D   2144635   G   D   2141883   G   D   Yes   S, NULL   Null   —       925   2136113   G   P   2145876   A   L   2143124   A   L   Yes   NS, NC   O07733   —       926   2137405   T   Q   2147123   C   R   2144416   C   R   Yes   NS, NC   O07732   guanylate cyclase                                                           activity       927   2141458   T   D   2151176   C   D   2148469   C   D   Yes   S, NULL   Null   —       928   2141625   T   M   2151343   C   T   2148636   C   T   Yes   NS, NC   O07728   —       929   2141958   T   T   2151676   G   P   2148969   G   P   Yes   NS, NC   O07727   monooxygenase activity       930   2145004   A   L   2154722   C   R   2152015   C   R   Yes   NS, NC   Q08129   catalase activity       931   2145783   A   T   2155501   G   T   2152794   G   T   Yes   S, NULL   Null   —       932   2146305   T   P   2156023   G   P   2153316   G   P   Yes   S, NULL   Null   —       933   2147148   T   G   2156866   G   G   2154159   G   G   Yes   S, NULL   Null   —       934   2147202   T   T   2156920   A   T   2154213   A   T   Yes   S, NULL   Null   —       935   2148389   C   G   2158107   T   D   2155400   T   D   Yes   NS, NC   O07721   NADPH: quinone                                                           reductase activity       936   2153341   A   L   2163058   G   L   2160351   G   L   Yes   S, NULL   Null   —       937   2159560   G   S   2167924   A   L   2165280   A   L   Yes   NS, NC   O53960   —       938   2159645   G   R   2168009   T   S   2165365   T   S   Yes   NS, NC   O53960   —       939   2159953   A   I   2168317   G   T   2165673   G   T   Yes   NS, NC   O53960   —       940   2163647   C   I   2172010   G   M   2169366   G   M   Yes   NS, NC   O53962   metabolism       941   2166221   A   R   2174584   C   R   2171940   C   R   Yes   S, NULL   Null   —       942   2167025   A   D   2175388   G   G   2172744   G   G   Yes   NS, NC   P95290   —       943   2167348   A   N   2175711   G   D   2173067   G   D   Yes   NS, NC   P95290   —       944   2168708   C   Null   2177071   T   Null   2174427   T   null   No   nc, NULL   Null   —       945   2180277   T   C   2188640   C   C   2185973   C   C   Yes   S, NULL   Null   —       946   2188349   C   L   2196713   G   V   2194046   G   V   Yes   NS, C   P95269   —       947   2188810   A   T   2197174   G   T   2194507   G   T   Yes   S, NULL   Null   —       948   2189303   T   T   2197667   C   A   2195000   C   A   Yes   NS, NC   P95268   —       949   2190686   G   R   2199050   C   G   2196383   C   G   Yes   NS, NC   P95266   —       950   2191050   G   L   2199414   A   F   2196747   A   F   Yes   NS, NC   P95265   —       951   2192930   C   R   2201294   T   H   2198627   T   null   Yes   NS, NC   P95260   —       952   2200251   G   G   2221333   A   D   2218667   A   D   Yes   NS, NC   O53979   S-adenosylmethionine-                                                           dependent                                                           methyltransferase                                                           activity       953   2201224   C   G   2222306   T   D   2219640   T   D   Yes   NS, NC   Q10875   amino acid-polyamine                                                           transporter activity       954   2204091   C   R   2225173   A   L   2222507   A   L   Yes   NS, NC   Q10840   ribonucleoside-                                                           diphosphate reductase                                                           activity       955   2205817   A   T   2226899   G   A   2224233   G   A   Yes   NS, NC   Q10873   integral to membrane       956   2208717   G   P   2229799   C   P   2227133   C   P   Yes   S, NULL   Null   —       957   2210402   G   Null   2231484   A   Null   2228818   A   null   No   nc, NULL   Null   —       958   2220658   G   P   2241740   A   P   2239074   A   P   Yes   S, NULL   Null   —       959   2221950   G   R   2243032   T   S   2240366   T   S   Yes   NS, NC   Q10859   enzyme activity       960   2223259   T   R   2244341   G   R   2241675   G   R   Yes   S, NULL   Null   —       961   2225876   C   V   2246958   G   V   2244292   G   V   Yes   S, NULL   Null   —       962   2226085   A   H   2247167   G   R   2244501   G   R   Yes   NS, NC   Q10856   —       963   2231155   A   S   2252237   G   G   2249571   G   G   Yes   NS, NC   Q10850   carbohydrate                                                           metabolism       964   2232015   C   A   2253097   A   A   2250431   A   A   Yes   S, NULL   Null   —       965   2234651   C   P   2255733   T   L   2253067   T   L   Yes   NS, NC   Q10850   carbohydrate                                                           metabolism       966   2237132   G   D   2258214   A   N   2255548   A   N   Yes   NS, NC   Q10848   —       967   2239016   T   Null   2260098   C   Null   2257432   C   null   No   nc, NULL   Null   —       968   2240157   G   E   2261239   A   E   2258573   A   E   Yes   S, NULL   Null   —       969   2240609   C   Null   2261691   G   Null   2259025   G   null   No   nc, NULL   Null   —       970   2244542   G   G   2265624   A   D   2262958   A   D   Yes   NS, NC   O53464   —       971   2246892   T   R   2267974   G   R   2265308   G   R   Yes   S, NULL   Null   —       972   2247313   T   L   2268395   C   Null   2265729   C   L   Yes   nc, NULL   Null   —       973   2253136   C   V   2269218   A   F   2271552   A   F   Yes   NS, NC   O53470   ATP binding activity       974   2253292   A   C   2269374   G   R   2271708   G   R   Yes   NS, NC   O53470   ATP binding activity       975   2255734   G   Null   2271818   A   Null   2274152   A   null   No   nc, NULL   Null   —       976   2258377   C   V   2274461   A   L   2276795   A   L   Yes   NS, C   O53473   ATP binding activity       977   2263994   T   L   2280079   C   P   2282413   C   P   Yes   NS, NC   O53476   —       978   2266289   T   V   2282374   C   V   2284708   C   V   Yes   S, NULL   Null   —       979   2266290   T   V   2282375   C   V   2284709   C   V   Yes   S, NULL   Null   —       980   2271395   A   V   2287480   G   A   2289814   G   A   Yes   NS, C   O53485   transporter activity       981   2272986   C   D   2289071   G   H   2291405   G   H   Yes   NS, NC   Q50575   enzyme activity       982   2275230   C   P   2291315   T   S   2293649   T   S   Yes   NS, NC   O53489   —       983   2282106   T   S   2298191   C   G   2300525   C   G   Yes   NS, NC   O53489   enzyme activity       984   2285002   C   L   2301087   T   L   2303421   T   L   Yes   S, NULL   Null   —       985   2304443   G   A   2320528   A   V   2322862   A   V   Yes   NS, C   O53498   biosynthesis       986   2312457   C   M   2328541   T   I   2330875   T   I   Yes   NS, NC   Q10672   porphyrin biosynthesis       987   2312508   A   G   2328592   G   G   2330926   G   G   Yes   S, NULL   Null   —       988   2312541   T   A   2328625   C   A   2330959   C   A   Yes   S, NULL   Null   —       989   2313380   T   P   2329464   C   P   2331798   C   P   Yes   S, NULL   Null   —       990   2317013   T   H   2335125   C   H   2337459   C   H   Yes   S, NULL   Null   —       991   2317887   T   L   2335999   C   P   2338333   C   P   Yes   NS, NC   Q10687   —       992   2319259   C   A   2337371   T   V   2339705   T   V   Yes   NS, C   Q10688   membrane       993   2322578   T   L   2340687   C   L   2343015   C   L   Yes   S, NULL   Null   —       994   2322919   A   T   2341028   G   A   2343356   G   A   Yes   NS, NC   Q10691   integral to membrane       995   2329583   T   I   2347738   C   T   2350008   C   T   Yes   NS, NC   Q10699   DNA binding activity       996   2332029   G   R   2350184   A   R   2352454   A   R   Yes   S, NULL   Null   —       997   2333365   A   M   2351520   G   T   2353790   G   T   Yes   NS, NC   Q10701   nucleic acid binding                                                           activity       998   2335359   A   V   2353514   G   A   2355783   G   A   Yes   NS, C   Q10704   —       999   2344034   T   S   2362191   G   A   2364459   G   A   Yes   NS, NC   O53499   nucleic acid binding                                                           activity       1000   2349668   C   G   2369184   G   R   2370093   G   R   Yes   NS, NC   O33244   endopeptidase activity       1001   2353673   C   P   2373246   A   T   2374098   A   T   Yes   NS, NC   O33248   —       1002   2353887   T   L   2373460   C   S   2374312   C   S   Yes   NS, NC   O33248   —       1003   2354188   T   Y   2373761   C   Y   2374613   C   Y   Yes   S, NULL   Null   —       1004   2356850   G   Null   2376423   A   Null   2377275   A   null   No   nc, NULL   Null   —       1005   2360168   G   Null   2379741   C   Null   2380593   C   null   Yes   nc, NULL   Null   —       1006   2364212   C   V   2383812   T   I   2382390   T   I   Yes   NS, C   O33259   dihydropteroate                                                           synthase activity       1007   2365161   C   R   2384761   A   R   2383339   A   R   Yes   S, NULL   Null   —       1008   2369039   A   D   2388639   G   G   2387216   G   null   Yes   NS, NC   O33261   amino acid-polyamine                                                           transporter activity       1009   2369143   A   S   2388743   G   G   2387320   G   G   Yes   NS, NC   O33261   amino acid-polyamine                                                           transporter activity       1010   2370697   G   Null   2390297   A   Null   2388874   A   null   No   nc, NULL   Null   —       1011   2373913   C   R   2393513   T   R   2392090   T   R   Yes   S, NULL   Null   —       1012   2377026   C   V   2396626   A   L   2395203   A   L   Yes   NS, C   O06239   undecaprenol kinase                                                           activity       1013   2384213   C   L   2403697   G   L   2402390   G   L   Yes   S, NULL   Null   —       1014   2393645   G   P   2413129   A   L   2411822   A   L   Yes   NS, NC   O06224   cytokinesis       1015   2393760   A   L   2413244   C   V   2411937   C   V   Yes   NS, C   O06224   cytokinesis       1016   2395865   A   V   2415349   C   V   2414042   C   V   Yes   S, NULL   Null   —       1017   2399656   G   V   2419140   A   V   2417833   A   V   Yes   S, NULL   Null   —       1018   2402330   G   A   2421814   A   V   2420507   A   V   Yes   NS, C   O06217   —       1019   2405256   G   Null   2424862   A   Null   2423555   A   null   No   nc, NULL   Null   —       1020   2405346   C   Null   2424952   A   Null   2423645   A   null   No   nc, NULL   Null   —       1021   2405863   C   R   2425469   T   R   2424162   T   R   Yes   S, NULL   Null   —       1022   2408026   G   A   2427632   A   V   2426325   A   V   Yes   NS, C   O06213   —       1023   2413856   G   Null   2434820   A   Null   2432155   A   null   No   nc, NULL   Null   —       1024   2416293   T   S   2437257   G   A   2434592   G   A   Yes   NS, NC   O53508   —       1025   2416871   A   L   2437835   G   P   2435170   G   P   Yes   NS, NC   O53509   —       1026   2417128   G   A   2438092   T   S   2435427   T   S   Yes   NS, NC   O53510   protein kinase activity       1027   2418638   T   K   2439602   G   T   2436937   G   T   Yes   NS, NC   O53511   DNA binding activity       1028   2421783   T   T   2442747   G   P   2440082   G   P   Yes   NS, NC   O53514   —       1029   2423986   C   G   2444950   A   G   2442285   A   G   Yes   S, NULL   Null   —       1030   2426460   T   I   2447424   G   I   2444759   G   I   Yes   S, NULL   Null   —       1031   2426573   G   Null   2447537   A   Null   2444872   A   null   No   nc, NULL   Null   —       1032   2427491   T   S   2448456   C   S   2445791   C   S   Yes   S, NULL   Null   —       1033   2428328   A   E   2449293   G   G   2446628   G   G   Yes   NS, NC   O53521   enzyme activity       1034   2433965   A   T   2454930   G   T   2452265   G   T   Yes   S, NULL   Null   —       1035   2433967   G   T   2454932   A   T   2452267   A   T   Yes   S, NULL   Null   —       1036   2438267   C   I   2459232   G   M   2456567   G   M   Yes   NS, NC   Q10387   electron transport       1037   2440692   A   S   2461543   C   A   2458821   C   A   Yes   NS, NC   Q10389   integral to membrane       1038   2447668   T   V   2468519   C   V   2465797   C   V   Yes   S, NULL   Null   —       1039   2449344   G   C   2470195   A   C   2467473   A   C   Yes   S, NULL   Null   —       1040   2449738   C   Null   2470589   A   Null   2467867   A   null   Yes   S, NULL   Null   —       1041   2452103   C   S   2472954   T   L   2470232   T   L   Yes   NS, NC   Q10397   porphyrin biosynthesis       1042   2454263   A   F   2475114   G   F   2472392   G   F   Yes   S, NULL   Null   —       1043   2455035   G   A   2475886   T   E   2473164   T   E   Yes   NS, NC   Q10399   enzyme activity       1044   2458114   G   L   2478965   C   F   2476243   C   F   Yes   NS, NC   Q10401   aminopeptidase activity       1045   2463948   G   G   2484799   A   D   2482077   A   D   Yes   NS, NC   Q10404   enzyme activity       1046   2465601   C   L   2486452   T   F   2483730   T   F   Yes   NS, NC   Q10405   integral to membrane       1047   2468463   G   Null   2489314   A   Null   2486590   A   null   No   nc, NULL   Null   —       1048   2474596   C   Null   2495447   T   Null   2492723   T   null   No   nc, NULL   Null   —       1049   2474647   C   L   2495498   T   L   2492774   T   L   Yes   S, NULL   Null   —       1050   2478070   A   D   2498921   G   G   2496197   G   G   Yes   NS, NC   Q10510   —       1051   2480295   C   A   2501146   T   A   2498422   T   A   Yes   S, NULL   Null   —       1052   2480652   C   L   2501502   T   F   2498778   T   F   Yes   NS, NC   Q10511   —       1053   2481905   T   Q   2502755   C   R   2500031   C   null   Yes   NS, NC   Q10513   kinesin complex       1054   2488510   A   I   2509360   G   T   2506634   G   T   Yes   NS, NC   Q10518   vitamin B12                                                           biosynthesis       1055   2488792   A   G   2509642   G   G   2506916   G   G   Yes   S, NULL   Null   —       1056   2490860   T   K   2511710   G   T   2508984   G   T   Yes   NS, NC   Q10522   integral to membrane       1057   2492611   C   R   2513461   G   G   2510735   G   G   Yes   NS, NC   Q10504   pyruvate                                                           dehydrogenase                                                           (lipoamide) activity       1058   2494787   T   V   2515637   G   V   2512911   G   V   Yes   S, NULL   Null   —       1059   2497280   T   T   2518130   C   T   2515404   C   T   Yes   S, NULL   Null   —       1060   2501788   A   E   2522726   C   D   2519999   C   D   Yes   NS, C   Q10526   —       1061   2504215   G   A   2525150   T   D   2522412   T   D   Yes   NS, NC   Q10528   DNA binding activity       1062   2507835   A   V   2528771   G   A   2526031   G   A   Yes   NS, C   O53528   lysine permease activity       1063   2508361   A   Null   2529297   G   Null   2526557   G   null   Yes   nc, NULL   Null   —       1064   2508860   C   G   2529796   G   A   2527056   G   A   Yes   NS, C   O53530   —       1065   2509390   C   R   2530326   A   R   2527586   A   R   Yes   S, NULL   Null   —       1066   2516165   C   P   2537209   G   P   2534414   G   P   Yes   S, NULL   Null   —       1067   2518574   A   V   2539618   G   V   2536823   G   V   Yes   S, NULL   Null   —       1068   2520531   G   Null   2541575   A   Null   2538780   A   null   No   nc, NULL   Null   —       1069   2524106   T   L   2545150   C   P   2542355   C   P   Yes   NS, NC   Q50693   membrane       1070   2525002   G   L   2546046   C   L   2543251   C   L   Yes   S, NULL   Null   —       1071   2525661   C   M   2546705   T   I   2543910   T   M   Yes   NS, NC   Q50689   —       1072   2528547   G   P   2549591   A   L   2546796   A   L   Yes   NS, NC   Q50687   glycerol metabolism       1073   2533496   T   Null   2555898   G   Null   2551745   G   null   No   nc, NULL   Null   —       1074   2536766   A   *   2559168   G   Q   2555015   G   Q   Yes   NS, TP   Q50679   protein disulfide                                                           oxidoreductase activity       1075   2537259   G   Null   2559661   C   Null   2555508   C   null   No   nc, NULL   Null   —       1076   2540378   C   A   2562781   T   V   2558628   T   V   Yes   NS, C   Q50675   membrane       1077   2541551   C   A   2563956   A   E   2559803   A   E   Yes   NS, NC   Q59570   thiosulfate                                                           sulfurtransferase                                                           activity       1078   2544362   G   Null   2566766   A   Null   2562613   A   null   No   nc, NULL   Null   —       1079   2550055   A   H   2572458   G   H   2568305   G   H   Yes   S, NULL   Null   —       1080   2553846   A   D   2576249   G   G   2572096   G   G   Yes   NS, NC   Q50660   molecular_function                                                           unknown       1081   2554841   G   V   2577244   A   V   2573091   A   V   Yes   S, NULL   Null   —       1082   2555589   A   W   2577992   G   R   2573839   G   R   Yes   NS, NC   Q50658   enzyme activity       1083   2558141   T   V   2580544   G   G   2576391   G   G   Yes   NS, C   Q50657   —       1084   2558704   A   R   2581107   C   R   2576954   C   R   Yes   S, NULL   Null   —       1085   2560796   A   K   2583199   G   Null   2579046   G   E   Yes   nc, NULL   Null   —       1086   2569172   G   V   2591575   C   L   2587422   C   L   Yes   NS, C   P71894   transporter activity       1087   2573528   T   T   2595931   C   A   2591777   C   A   Yes   NS, NC   P71889   —       1088   2579779   C   A   2602182   G   A   2598028   G   A   Yes   S, NULL   Null   —       1089   2582470   C   L   2604873   A   L   2600719   A   null   Yes   S, NULL   Null   —       1090   2582888   T   D   2605291   G   E   2601137   G   E   Yes   NS, C   P71880   malic enzyme activity       1091   2583687   C   L   2606090   A   I   2601936   A   I   Yes   NS, C   P71880   malic enzyme activity       1092   2586084   C   Null   2608486   T   Null   2604332   T   null   Yes   nc, NULL   Null   —       1093   2589179   T   H   2611581   C   H   2607427   C   H   Yes   S, NULL   Null   —       1094   2589896   T   R   2612298   G   R   2608144   G   R   Yes   S, NULL   Null   —       1095   2592420   T   V   2614821   C   A   2610667   C   A   Yes   NS, C   P95235   membrane       1096   2594770   A   Null   2617171   G   Null   2613017   G   null   Yes   S, NULL   Null   —       1097   2596868   C   Null   2619269   T   Null   2615115   T   null   No   nc, NULL   Null   —       1098   2603521   C   A   2625922   T   A   2621768   T   A   Yes   S, NULL   Null   —       1099   2609911   G   R   2641838   A   H   2639170   A   H   Yes   NS, NC   O05839   transcription factor                                                           activity       1100   2611180   A   F   2643107   G   F   2640439   G   F   Yes   S, NULL   Null   —       1101   2614613   A   A   2646540   G   A   2643872   G   A   Yes   S, NULL   Null   —       1102   2626747   A   V   2658674   G   A   2656006   G   A   Yes   NS, C   O05819   enzyme activity       1103   2627613   C   G   2659540   T   G   2656872   T   G   Yes   S, NULL   Null   —       1104   2643121   T   Q   2675048   C   R   2672380   C   R   Yes   NS, NC   P71717   enzyme activity       1105   2650664   T   T   2682591   C   A   2679923   C   A   Yes   NS, NC   P71756   magnesium ion binding                                                           activity       1106   2652240   G   T   2684167   A   I   2681499   A   I   Yes   NS, NC   P71754   —       1107   2656797   C   A   2688724   T   A   2686056   T   A   Yes   S, NULL   Null   —       1108   2657264   A   Q   2689191   G   R   2686523   G   R   Yes   NS, NC   P71750   gamma-glutamyl                                                           transferase activity       1109   2659785   C   P   2691711   T   S   2689043   T   S   Yes   NS, NC   P71749   —       1110   2660947   A   N   2692873   G   S   2690205   G   S   Yes   NS, C   P71748   oxygen transporter                                                           activity       1111   2661446   C   A   2693375   T   A   2690707   T   A   Yes   S, NULL   Null   —       1112   2661841   G   S   2693770   A   N   2691102   A   N   Yes   NS, C   P71748   oxygen transporter                                                           activity       1113   2663078   T   H   2695007   C   R   2692339   C   R   Yes   NS, NC   P71746   transporter activity       1114   2668981   G   L   2700910   C   V   2698242   C   V   Yes   NS, C   P71740   —       1115   2671087   T   G   2703016   G   G   2700348   G   G   Yes   S, NULL   Null   —       1116   2671898   T   A   2703827   C   A   2701157   C   A   Yes   S, NULL   Null   —       1117   2677979   G   A   2709793   A   A   2706644   A   A   Yes   S, NULL   Null   —       1118   2681098   A   L   2712911   C   R   2709762   C   R   Yes   NS, NC   P71728   DNA binding activity       1119   2683310   C   A   2715123   T   T   2711974   T   T   Yes   NS, NC   P71727   —       1120   2684991   C   R   2716804   T   R   2713655   T   R   Yes   S, NULL   Null   —       1121   2685491   A   V   2717304   G   A   2714155   G   A   Yes   NS, C   P71724   enzyme activity       1122   2686456   T   S   2718269   C   G   2715120   C   G   Yes   NS, NC   O86328   nicotinate-nucleotide                                                           adenylyltransferase                                                           activity       1123   2687242   A   Null   2719055   G   Null   2715906   G   null   No   nc, NULL   Null   —       1124   2689080   A   Y   2720893   G   H   2717744   R   ?   Yes   NS, C   P71924   DNA binding activity       1125   2689137   C   A   2720950   T   T   2717801   Y   ?   Yes   NS, NC   P71924   DNA binding activity       1126   2689139   A   I   2720952   G   T   2717803   R   ?   Yes   NS, NC   P71924   DNA binding activity       1127   2691689   C   L   2723504   T   L   2720355   T   L   Yes   S, NULL   Null   —       1128   2692030   G   L   2723845   A   F   2720696   A   F   Yes   NS, NC   P71922   nucleotide binding                                                           activity       1129   2693966   T   V   2725801   C   Null   2722652   C   V   Yes   nc, NULL   Null   —       1130   2702213   T   V   2734048   C   A   2730899   C   A   Yes   NS, C   P71913   ribokinase activity       1131   2705180   A   Null   2737015   G   Null   2733866   G   null   Yes   nc, NULL   Null   —       1132   2708856   C   Null   2740691   T   Null   2737539   T   null   Yes   nc, NULL   Null   —       1133   2709921   T   L   2741756   G   L   2738604   G   L   Yes   S, NULL   Null   —       1134   2719463   A   T   2751298   G   T   2748146   G   T   Yes   S, NULL   Null   —       1135   2720611   G   D   2752446   A   N   2749294   A   N   Yes   NS, NC   O53178   —       1136   2721171   T   Null   2753006   C   Null   2749854   C   null   No   nc, NULL   Null   —       1137   2728310   T   R   2760145   C   R   2756992   C   R   Yes   S, NULL   Null   —       1138   2729181   A   I   2761016   G   M   2757863   G   M   Yes   NS, NC   O53186   transporter activity       1139   2733102   A   L   2764937   G   P   2761784   G   P   Yes   NS, NC   O53189   cytokinesis       1140   2736005   C   Q   2767840   T   Q   2764687   T   Q   Yes   S, NULL   Null   —       1141   2740904   A   S   2772739   C   A   2769586   C   A   Yes   NS, NC   O53196   nucleic acid binding                                                           activity       1142   2741117   C   G   2772952   T   S   2769799   T   S   Yes   NS, NC   O53196   nucleic acid binding                                                           activity       1143   2742343   C   S   2774178   G   W   2771025   G   W   Yes   NS, NC   O53198   alpha-amylase activity       1144   2743386   T   Null   2775221   C   Null   2772068   C   null   No   nc, NULL   Null   —       1145   2745044   A   V   2776879   G   A   2773726   G   A   Yes   NS, C   O53201   —       1146   2751087   C   T   2782925   T   T   2779772   T   T   Yes   S, NULL   Null   —       1147   2754350   C   S   2787546   T   N   2783035   T   N   Yes   NS, C   O53207   glycerol-3-phosphate O-                                                           acyltransferase activity       1148   2757260   C   G   2790456   A   C   2785945   A   C   Yes   NS, NC   O53208   metabolism       1149   2757900   T   D   2791096   C   G   2786585   C   G   Yes   NS, NC   O53209   molecular_function                                                           unknown       1150   2758277   G   A   2791473   A   A   2786962   A   A   Yes   S, NULL   Null   —       1151   2762360   T   T   2795557   C   T   2791046   C   T   Yes   S, NULL   Null   —       1152   2763122   A   V   2796320   G   A   2791809   G   A   Yes   NS, C   O53212   —       1153   2763158   G   T   2796356   C   S   2791845   C   S   Yes   NS, C   O53212   —       1154   2771624   A   H   2804833   G   H   2800322   G   H   Yes   S, NULL   Null   —       1155   2774283   A   D   2807484   C   A   2802973   C   A   Yes   NS, NC   O53217   thymidylate synthase                                                           activity       1156   2776115   A   W   2809316   G   R   2804805   G   R   Yes   NS, NC   O06159   protein binding activity       1157   2777179   T   S   2810380   C   G   2805869   C   G   Yes   NS, NC   O06160   —       1158   2779539   G   G   2812740   A   G   2808229   A   G   Yes   S, NULL   Null   —       1159   2784243   T   L   2817444   G   F   2812933   G   F   Yes   NS, NC   O06165   biotin carboxylase                                                           activity       1160   2785043   T   S   2818244   C   G   2813733   C   G   Yes   NS, NC   O06165   biotin carboxylase                                                           activity       1161   2789771   T   P   2822972   C   P   2818461   C   P   Yes   S, NULL   Null   —       1162   2792263   A   K   2825464   G   K   2820953   G   K   Yes   S, NULL   Null   —       1163   2798279   G   G   2831480   A   G   2826969   A   G   Yes   S, NULL   Null   —       1164   2802192   T   Null   2835393   C   Null   2830882   C   null   No   nc, NULL   Null   —       1165   2803099   C   A   2836300   G   A   2831789   G   A   Yes   S, NULL   Null   —       1166   2803100   C   A   2836301   G   A   2831790   G   A   Yes   S, NULL   Null   —       1167   2804844   A   M   2838045   G   V   2833534   G   V   Yes   NS, NC   O53226   —       1168   2807819   G   R   2841020   A   C   2836509   A   C   Yes   NS, NC   P95029   enzyme activity       1169   2814078   G   D   2847279   A   D   2842768   A   D   Yes   S, NULL   Null   —       1170   2818088   A   V   2851289   G   V   2846777   G   V   Yes   S, NULL   Null   —       1171   2818694   G   Q   2851895   C   E   2847383   C   E   Yes   NS, NC   P95025   —       1172   2819952   A   E   2853153   G   G   2848641   G   G   Yes   NS, NC   P95024   nucleic acid binding                                                           activity       1173   2824432   A   D   2857633   G   D   2853121   G   D   Yes   S, NULL   Null   —       1174   2825466   T   D   2858667   G   A   2854156   G   A   Yes   NS, NC   P95020   RNA binding activity       1175   2837839   T   Null   2870384   C   Null   2866530   C   null   No   nc, NULL   Null   —       1176   2843260   G   N   2875806   C   K   2871952   C   K   Yes   NS, NC   O07438   nucleic acid binding                                                           activity       1177   2846432   T   D   2878978   C   G   2875124   C   G   Yes   NS, NC   Q50739   nucleotide binding                                                           activity       1178   2849417   C   T   2881964   T   I   2878109   T   I   Yes   NS, NC   Q50737   —       1179   2853851   A   S   2886398   G   G   2882543   G   G   Yes   NS, NC   Q50732   —       1180   2854021   G   E   2886568   A   E   2882713   A   E   Yes   S, NULL   Null   —       1181   2854631   T   S   2887178   G   A   2883323   G   A   Yes   NS, NC   Q50732   —       1182   2858117   T   L   2890666   C   L   2886811   C   L   Yes   S, NULL   Null   —       1183   2863708   A   V   2896258   G   A   2892403   G   A   Yes   NS, C   Q50649   nucleic acid binding                                                           activity       1184   2865290   C   Null   2897840   G   Null   2893985   G   null   No   nc, NULL   Null   —       1185   2865319   G   Null   2897869   A   Null   2894014   A   null   No   nc, NULL   Null   —       1186   2866213   T   A   2898763   C   A   2894908   C   A   Yes   S, NULL   Null   —       1187   2868616   A   *   2901166   G   W   2897311   G   W   Yes   NS, TP   Q50644   hydrolase activity       1188   2871372   A   T   2903922   G   A   2900067   G   A   Yes   NS, NC   Q50642   enzyme activity       1189   2871964   A   Q   2904514   G   R   2900659   G   R   Yes   NS, NC   Q50642   enzyme activity       1190   2874457   T   F   2907007   G   V   2903152   G   V   Yes   NS, NC   Q50639   peptidyl-prolyl cis-trans                                                           isomerase activity       1191   2879964   A   T   2912514   G   T   2908659   G   T   Yes   S, NULL   Null   —       1192   2880160   G   P   2912710   T   T   2908855   T   T   Yes   NS, NC   Q50635   protein targeting       1193   2880535   T   T   2913085   C   A   2909230   C   A   Yes   NS, NC   Q50635   protein targeting       1194   2881707   C   S   2914257   T   N   2910402   T   N   Yes   NS, C   Q50634   protein targeting       1195   2886244   A   Y   2918794   T   F   2914939   T   F   Yes   NS, C   Q50631   enzyme activity       1196   2887118   A   L   2919668   G   L   2915813   G   L   Yes   S, NULL   Null   —       1197   2888634   A   T   2921184   G   A   2917329   G   A   Yes   NS, NC   Q50631   enzyme activity       1198   2890241   A   S   2922791   G   G   2918936   G   G   Yes   NS, NC   Q50630   —       1199   2890386   A   D   2922936   G   G   2919081   G   G   Yes   NS, NC   Q50630   —       1200   2890432   C   G   2922982   T   G   2919127   T   G   Yes   S, NULL   Null   —       1201   2893419   C   R   2925960   T   C   2922105   T   C   Yes   NS, NC   Q50625   —       1202   2894748   A   A   2927289   G   A   2923434   G   A   Yes   S, NULL   Null   —       1203   2894968   T   I   2927509   G   S   2923654   G   S   Yes   NS, NC   Q50622   integral to membrane       1204   2896114   A   L   2928655   G   L   2924800   G   L   Yes   S, NULL   Null   —       1205   2900347   G   L   2932888   A   F   2929033   A   F   Yes   NS, NC   O06209   acyl-CoA metabolism       1206   2903343   T   S   2935884   C   P   2932029   C   P   Yes   NS, NC   O06206   —       1207   2911002   A   H   2943543   G   Null   2939688   G   null   Yes   nc, NULL   Null   —       1208   2913009   A   I   2945541   G   V   2941686   G   V   Yes   NS, C   O06198   —       1209   2913792   C   Null   2946324   T   Null   2942469   T   null   No   nc, NULL   Null   —       1210   2920364   A   H   2952899   G   H   2949044   G   H   Yes   S, NULL   Null   —       1211   2920770   T   Null   2953305   G   Null   2949450   G   null   No   nc, NULL   Null   —       1212   2922696   T   L   2955231   C   S   2951376   C   S   Yes   NS, NC   O06184   —       1213   2922723   G   R   2955258   C   P   2951403   C   P   Yes   NS, NC   O06184   —       1214   2926786   G   Null   2959321   A   Null   2955467   A   null   No   nc, NULL   Null   —       1215   2929067   G   G   2961602   C   G   2957748   C   G   Yes   S, NULL   Null   —       1216   2935735   C   A   2968270   T   V   2964416   T   V   Yes   NS, C   P71942   protein tyrosine                                                           phosphatase activity       1217   2935930   C   Null   2968465   G   Null   2964611   G   null   Yes   nc, NULL   Null   —       1218   2938515   A   R   2982032   G   R   2976820   G   R   Yes   S, NULL   Null   —       1219   2941411   C   A   2984929   G   G   2979718   G   G   Yes   NS, C   P71965   —       1220   2941695   A   K   2985213   G   E   2980002   G   E   Yes   NS, NC   P71965   —       1221   2945109   G   D   2988627   C   H   2983416   C   H   Yes   NS, NC   P71969   —       1222   2948228   G   S   2991691   C   S   2986535   C   S   Yes   S, NULL   Null   —       1223   2950721   C   L   2994184   T   L   2989028   T   L   Yes   S, NULL   Null   —       1224   2950791   C   G   2994254   G   A   2989098   G   A   Yes   NS, C   O53231   uroporphyrinogen                                                           decarboxylase activity       1225   2953961   T   V   2997322   C   A   2992268   C   A   Yes   NS, C   O07183   nucleic acid binding                                                           activity       1226   2956998   C   S   3000359   T   L   2995305   T   L   Yes   NS, NC   O07185   —       1227   2959751   G   G   3003112   C   A   2998058   C   A   Yes   NS, C   O07187   transport       1228   2959795   T   C   3003156   G   G   2998102   G   G   Yes   NS, NC   O07187   transport       1229   2963534   A   Y   3006895   G   Y   3001840   G   Y   Yes   S, NULL   Null   —       1230   2963874   G   R   3007235   A   *   3002180   A   *   Yes   NS, TP   O07192   amino acid-polyamine                                                           transporter activity       1231   2967056   G   V   3010417   A   I   3005362   A   I   Yes   NS, C   O07194   transport       1232   2968202   T   S   3011563   G   R   3006508   G   R   Yes   NS, NC   O07196   nucleic acid binding                                                           activity       1233   2969755   T   N   3013116   C   D   3008061   C   D   Yes   NS, NC   O07198   —       1234   2978578   G   S   3021939   C   T   3016884   C   T   Yes   NS, C   O07210   —       1235   2979168   A   A   3022529   G   A   3017474   G   A   Yes   S, NULL   Null   —       1236   2979744   T   V   3023105   G   V   3018050   G   V   Yes   S, NULL   Null   —       1237   2984242   G   W   3027603   C   S   3022542   C   S   Yes   NS, NC   O07213   —       1238   2984434   C   A   3027795   T   V   3022734   T   V   Yes   NS, C   O07213   —       1239   2984591   A   L   3027952   G   L   3022891   G   L   Yes   S, NULL   Null   —       1240   2987804   G   H   3031165   A   Y   3026104   A   Y   Yes   NS, C   O07218   cell wall catabolism       1241   2988773   C   A   3032134   T   V   3027073   T   V   Yes   NS, C   Q50765   DNA binding activity       1242   2993548   G   T   3036909   A   I   3031848   A   I   Yes   NS, NC   O33229   acyl-CoA                                                           dehydrogenase activity       1243   2993831   C   A   3037192   G   P   3032131   G   P   Yes   NS, NC   O33229   acyl-CoA                                                           dehydrogenase activity       1244   2998193   C   Null   3041554   T   Null   3036491   T   null   No   nc, NULL   Null   —       1245   2998315   A   V   3041676   G   A   3036613   G   A   Yes   NS, C   O33234   —       1246   2998989   C   L   3042350   G   F   3037287   G   F   Yes   NS, NC   O33234   —       1247   3001500   T   V   3044861   C   V   3039798   C   V   Yes   S, NULL   Null   —       1248   3011613   A   G   3055059   C   G   3049784   C   G   Yes   S, NULL   Null   —       1249   3011639   A   D   3055085   G   G   3049810   G   G   Yes   NS, NC   O33284   —       1250   3012496   G   L   3055919   A   L   3050644   A   L   Yes   S, NULL   Null   —       1251   3014181   G   Q   3057604   T   K   3052329   T   K   Yes   NS, NC   P31511   —       1252   3015844   G   E   3059267   A   E   3053992   A   null   Yes   S, NULL   Null   —       1253   3026379   C   V   3069802   G   V   3064527   G   V   Yes   S, NULL   Null   —       1254   3029501   A   *   3072924   G   Q   3067649   G   Q   Yes   NS, TP   O33304   —       1255   3033865   C   R   3077288   G   P   3072013   G   P   Yes   NS, NC   O33310   —       1256   3035400   A   S   3078823   G   P   3073548   G   P   Yes   NS, NC   O33311   —       1257   3036408   A   A   3079831   G   A   3074556   G   A   Yes   S, NULL   Null   —       1258   3036451   G   S   3079874   A   F   3074599   A   F   Yes   NS, NC   O33312   —       1259   3038305   A   I   3081728   G   T   3076453   G   T   Yes   NS, NC   P72024   dihydrodipicolinate                                                           reductase activity       1260   3038502   T   E   3081925   G   D   3076650   G   D   Yes   NS, C   P72024   dihydrodipicolinate                                                           reductase activity       1261   3043278   T   I   3086725   C   M   3081450   C   M   Yes   NS, NC   O33321   DNA binding activity       1262   3045174   G   V   3088622   A   V   3083347   A   V   Yes   S, NULL   Null   —       1263   3049237   G   Null   3092685   A   Null   3087410   A   null   No   nc, NULL   Null   —       1264   3053917   C   A   3097365   A   D   3092089   A   D   Yes   NS, NC   O33330   transcription factor                                                           activity       1265   3054660   A   G   3098108   G   G   3092832   G   G   Yes   S, NULL   Null   —       1266   3055488   C   Null   3098936   G   Null   3093660   G   null   No   nc, NULL   Null   —       1267   3058474   C   A   3101922   T   T   3096643   T   T   Yes   NS, NC   O33334   recombinase activity       1268   3058662   A   V   3102110   G   A   3096831   G   A   Yes   NS, C   O33334   recombinase activity       1269   3060738   G   C   3104186   A   C   3098907   A   C   Yes   S, NULL   Null   —       1270   3061693   A   F   3105141   C   C   3099862   C   C   Yes   NS, NC   P71655   —       1271   3063629   A   A   3107077   G   A   3101798   G   A   Yes   S, NULL   Null   —       1272   3066230   C   D   3109675   T   D   3104396   T   D   Yes   S, NULL   Null   —       1273   3069429   A   V   3112874   G   A   3107595   G   A   Yes   NS, C   P71647   —       1274   3069475   T   T   3112920   C   A   3107641   C   A   Yes   NS, NC   P71647   —       1275   3072095   C   P   3115540   A   T   3110261   A   T   Yes   NS, NC   P71642   —       1276   3074999   G   V   3118446   A   I   3113166   A   I   Yes   NS, C   P71638   —       1277   3081797   A   *   3125232   G   Q   3119439   G   Q   Yes   NS, TP   P71635   —       1278   3084028   G   R   3127463   T   R   3121670   T   R   Yes   S, NULL   Null   —       1279   3089119   G   P   3132545   T   H   3126761   T   H   Yes   NS, NC   P71628   —       1280   3089527   T   E   3132953   G   A   3127169   G   A   Yes   NS, NC   P71627   —       1281   3089534   G   L   3132960   A   L   3127176   A   L   Yes   S, NULL   Null   —       1282   3089536   T   Q   3132962   G   Q   3127178   G   Q   Yes   S, NULL   Null   —       1283   3089537   G   Q   3132963   T   Q   3127179   T   Q   Yes   S, NULL   Null   —       1284   3089546   G   L   3132972   C   V   3127188   C   V   Yes   NS, C   P71627   —       1285   3089625   G   C   3133051   C   C   3127267   C   C   Yes   S, NULL   Null   —       1286   3089626   C   C   3133052   G   C   3127268   G   C   Yes   S, NULL   Null   —       1287   3091410   A   R   3134836   G   R   3129052   G   R   Yes   S, NULL   Null   —       1288   3092467   G   G   3135893   A   G   3130109   A   G   Yes   S, NULL   Null   —       1289   3092732   G   A   3136158   T   E   3130374   T   E   Yes   NS, NC   P71624   —       1290   3093808   C   Null   3137234   T   Null   3131450   T   null   No   nc, NULL   Null   —       1291   3094520   T   C   3137946   C   R   3132162   C   R   Yes   NS, NC   P71621   enzyme activity       1292   3096227   G   P   3139653   C   A   3133869   C   A   Yes   NS, NC   P71619   transporter activity       1293   3096535   A   L   3139961   G   P   3134175   G   L   Yes   NS, NC   P71619   transporter activity       1294   3096724   A   I   3140150   C   S   3134364   C   I   Yes   NS, NC   P71619   transporter activity       1295   3098942   T   L   3142369   C   L   3136583   C   L   Yes   S, NULL   Null   —       1296   3099150   A   L   3142577   G   P   3136791   G   P   Yes   NS, NC   P71616   transporter activity       1297   3103523   C   E   3146950   T   E   3141164   T   E   Yes   S, NULL   Null   —       1298   3108827   T   T   3152254   C   A   3146468   C   A   Yes   NS, NC   O05814   tRNA ligase activity       1299   3108991   C   R   3152418   T   H   3146632   T   H   Yes   NS, NC   O05814   tRNA ligase activity       1300   3111157   C   R   3154584   T   R   3148798   T   R   Yes   S, NULL   Null   —       1301   3111158   C   R   3154585   G   R   3148799   G   R   Yes   S, NULL   Null   —       1302   3114301   G   C   3157782   C   W   3151996   C   W   Yes   NS, NC   O05810   ATP binding activity       1303   3115235   T   S   3158716   C   G   3152930   C   G   Yes   NS, NC   O05809   nucleotide binding                                                           activity       1304   3115753   T   Q   3159234   C   R   3153448   C   R   Yes   NS, NC   O05809   nucleotide binding                                                           activity       1305   3119320   C   N   3162801   A   K   3157013   A   K   Yes   NS, NC   O05806   —       1306   3121306   T   D   3164787   C   D   3158999   C   D   Yes   S, NULL   Null   —       1307   3127009   G   P   3170490   C   P   3164702   C   P   Yes   S, NULL   Null   —       1308   3131012   G   R   3174493   A   C   3168651   A   C   Yes   NS, NC   O33344   —       1309   3131107   G   P   3174588   C   R   3168746   C   R   Yes   NS, NC   O33344   —       1310   3133059   A   I   3176540   G   I   3170698   G   I   Yes   S, NULL   Null   —       1311   3135930   G   A   3179411   T   D   3173569   T   D   Yes   NS, NC   O33350   isoprenoid biosynthesis       1312   3137504   A   F   3180985   C   V   3175143   C   V   Yes   NS, NC   O33351   metalloendopeptidase                                                           activity       1313   3141276   T   Null   3184757   G   Null   3178914   G   null   Yes   nc, NULL   Null   —       1314   3144308   C   R   3187789   T   W   3181946   T   R   Yes   NS, NC   Q10802   integral to membrane       1315   3145285   G   H   3188766   A   Y   3182923   A   Y   Yes   NS, C   Q10803   membrane       1316   3145758   G   A   3189239   A   A   3183396   A   A   Yes   S, NULL   Null   —       1317   3146096   C   Null   3189577   T   Null   3183734   T   null   No   nc, NULL   Null   —       1318   3146180   C   K   3189661   T   K   3183818   T   K   Yes   S, NULL   Null   —       1319   3149728   T   Null   3193210   C   Null   3187366   C   null   No   nc, NULL   Null   —       1320   3150908   A   I   3194389   T   K   3188545   T   K   Yes   NS, NC   Q10809   —       1321   3152247   C   V   3195728   T   V   3189884   T   V   Yes   S, NULL   Null   —       1322   3154848   A   M   3198329   G   T   3192485   G   T   Yes   NS, NC   Q10788   translation elongation                                                           factor activity       1323   3156820   G   V   3200301   A   V   3194457   A   V   Yes   S, NULL   Null   —       1324   3162781   C   G   3206262   T   E   3200418   T   E   Yes   NS, NC   Q10817   DNA mediated                                                           transformation       1325   3163766   T   L   3207247   A   L   3201403   A   L   Yes   S, NULL   Null   —       1326   3169156   T   H   3212637   C   R   3206793   C   R   Yes   NS, NC   Q10793   RNA binding activity       1327   3169605   T   N   3213086   C   D   3207242   C   D   Yes   NS, NC   Q10789   proteolysis and                                                           peptidolysis       1328   3179819   T   E   3223300   C   E   3217456   C   E   Yes   S, NULL   Null   —       1329   3185717   A   W   3229198   G   R   3223352   G   R   Yes   NS, NC   Q10961   enzyme activity       1330   3186529   C   R   3230010   A   L   3224164   A   L   Yes   NS, NC   Q10961   enzyme activity       1331   3187380   A   D   3230861   G   D   3225015   G   D   Yes   S, NULL   Null   —       1332   3192343   C   G   3235712   G   R   3230035   G   R   Yes   NS, NC   Q10970   ATP-binding cassette                                                           (ABC) transporter                                                           activity       1333   3193344   C   R   3236713   A   L   3231036   A   L   Yes   NS, NC   Q10970   ATP-binding cassette                                                           (ABC) transporter                                                           activity       1334   3199928   C   Null   3243352   T   Null   3237675   T   null   No   nc, NULL   Null   —       1335   3200987   G   V   3244411   A   M   3238734   A   M   Yes   NS, NC   Q10976   enzyme activity       1336   3203120   C   T   3246544   A   N   3240867   A   N   Yes   NS, C   Q10977   enzyme activity       1337   3204152   A   Q   3247576   G   R   3241899   G   R   Yes   NS, NC   Q10977   enzyme activity       1338   3211268   T   A   3254692   C   A   3249015   C   A   Yes   S, NULL   Null   —       1339   3211453   T   L   3254877   G   R   3249200   G   R   Yes   NS, NC   Q10978   enzyme activity       1340   3217579   A   G   3261003   C   G   3255326   C   G   Yes   S, NULL   Null   —       1341   3219201   A   I   3262625   G   M   3256948   G   M   Yes   NS, NC   P96203   enzyme activity       1342   3222603   G   S   3266027   A   S   3260350   A   S   Yes   S, NULL   Null   —       1343   3224288   C   A   3267712   A   E   3262035   A   E   Yes   NS, NC   P96203   enzyme activity       1344   3227610   G   D   3271034   A   N   3265357   A   N   Yes   NS, NC   P96204   enzyme activity       1345   3229711   G   D   3273135   C   H   3267458   C   H   Yes   NS, NC   P96205   nucleotide binding                                                           activity       1346   3230432   T   L   3273856   C   L   3268179   C   L   Yes   S, NULL   Null   —       1347   3238652   A   C   3282076   T   S   3276399   T   S   Yes   NS, NC   P96291   enzyme activity       1348   3239912   T   I   3283336   G   S   3277659   G   S   Yes   NS, NC   P96290   enzyme activity       1349   3240065   G   R   3283489   A   Q   3277812   A   Q   Yes   NS, NC   P96290   enzyme activity       1350   3240165   C   G   3283589   G   G   3277912   G   G   Yes   S, NULL   Null   —       1351   3242680   A   V   3286104   C   V   3280427   C   V   Yes   S, NULL   Null   —       1352   3243139   T   A   3286563   C   A   3280886   C   A   Yes   S, NULL   Null   —       1353   3248962   A   V   3292272   G   A   3286595   G   A   Yes   NS, C   P96285   alcohol dehydrogenase                                                           activity       1354   3249193   C   G   3292503   A   V   3286826   A   V   Yes   NS, C   P96285   alcohol dehydrogenase                                                           activity       1355   3250170   A   A   3293480   G   A   3287803   G   A   Yes   S, NULL   Null   —       1356   3253409   G   R   3296718   C   G   3291041   C   G   Yes   NS, NC   P96284   enzyme activity       1357   3257940   T   T   3301249   C   A   3295572   C   A   Yes   NS, NC   P95141   enzyme activity       1358   3259371   T   Null   3302680   C   Null   3297003   C   null   Yes   nc, NULL   Null   —       1359   3265154   T   H   3308463   C   R   3302785   C   R   Yes   NS, NC   P95137   —       1360   3265769   A   E   3309078   G   E   3303400   G   E   Yes   S, NULL   Null   —       1361   3266065   C   T   3309374   T   I   3303696   T   I   Yes   NS, NC   P95136   —       1362   3267563   A   Null   3310872   G   Null   3305194   G   null   Yes   S, NULL   Null   —       1363   3267807   C   D   3311116   G   D   3305438   G   D   Yes   S, NULL   Null   —       1364   3269417   T   V   3312725   C   V   3307047   C   V   Yes   S, NULL   Null   —       1365   3271101   G   A   3314409   A   A   3308731   A   A   Yes   S, NULL   Null   —       1366   3277243   A   S   3320551   G   S   3314873   G   S   Yes   S, NULL   Null   —       1367   3283243   C   H   3326551   A   N   3320873   A   N   Yes   NS, NC   P95124   —       1368   3291984   C   G   3335294   T   D   3329616   T   D   Yes   NS, NC   P95116   recombinase activity       1369   3292201   C   A   3335511   T   T   3329833   T   T   Yes   NS, NC   P95116   recombinase activity       1370   3292395   C   R   3335705   G   P   3330027   G   P   Yes   NS, NC   P95116   recombinase activity       1371   3301607   T   E   3345044   G   D   3339424   G   D   Yes   NS, C   O53237   3-isopropylmalate                                                           dehydratase activity       1372   3303630   T   E   3347067   G   A   3341447   G   A   Yes   NS, NC   O53239   —       1373   3304818   A   T   3348255   G   A   3342635   G   A   Yes   NS, NC   O53240   —       1374   3309535   G   L   3352916   A   F   3347295   A   F   Yes   NS, NC   P95313   3-isopropylmalate                                                           dehydrogenase activity       1375   3312033   A   S   3355414   T   C   3349793   T   C   Yes   NS, NC   O53244   —       1376   3313133   C   P   3356514   T   P   3350893   T   P   Yes   S, NULL   Null   —       1377   3321979   A   D   3365361   G   G   3359739   G   G   Yes   NS, NC   O53253   —       1378   3326484   T   Null   3369866   G   Null   3364244   G   null   No   nc, NULL   Null   —       1379   3327875   C   V   3371257   T   I   3365635   T   I   Yes   NS, C   O53258   amidase activity       1380   3327980   T   T   3371362   C   A   3365740   C   A   Yes   NS, NC   O53258   amidase activity       1381   3328016   A   L   3371398   G   L   3365776   G   L   Yes   S, NULL   Null   —       1382   3333886   C   V   3377268   G   L   3371647   G   L   Yes   NS, C   P31500   —       1383   3338640   T   G   3382077   C   G   3377816   C   G   Yes   S, NULL   Null   —       1384   3339158   T   T   3382595   C   A   3378334   C   A   Yes   NS, NC   P96354   peroxidase activity       1385   3343458   C   Null   3386895   T   Null   3382634   T   null   Yes   nc, NULL   Null   —       1386   3343463   G   Null   3386900   A   Null   3382639   A   null   Yes   nc, NULL   Null   —       1387   3343657   A   V   3387094   G   A   3382833   G   A   Yes   NS, C   O53275   electron transporter                                                           activity       1388   3345242   C   V   3388679   T   V   3384418   T   V   Yes   S, NULL   Null   —       1389   3353514   C   R   3396951   T   Q   3392690   T   Q   Yes   NS, NC   O53283   —       1390   3354831   G   A   3398268   T   D   3394007   T   D   Yes   NS, NC   O53284   —       1391   3359515   A   S   3402952   C   A   3398691   C   A   Yes   NS, NC   O53289   phosphoserine                                                           phosphatase activity       1392   3362817   A   Null   3406254   G   Null   3401993   G   null   No   nc, NULL   Null   —       1393   3366744   A   R   3410181   G   R   3405920   G   R   Yes   S, NULL   Null   —       1394   3371878   G   Null   3415329   A   Null   3411054   A   null   Yes   nc, NULL   Null   —       1395   3376988   T   Y   3420439   C   Y   3416164   C   Y   Yes   S, NULL   Null   —       1396   3377371   G   G   3420822   A   D   3416547   A   D   Yes   NS, NC   P95099   monooxygenase activity       1397   3384993   T   C   3428443   G   G   3424236   G   G   Yes   NS, NC   P95095   cellular response to                                                           starvation       1398   3385588   C   P   3429038   T   L   3424831   T   L   Yes   NS, NC   P95095   cellular response to                                                           starvation       1399   3386152   A   Null   3429602   G   Null   3425395   G   null   Yes   nc, NULL   Null   —       1400   3392209   G   Null   3435659   C   Null   3431452   C   null   Yes   nc, NULL   Null   —       1401   3394933   A   I   3438383   G   I   3434176   G   I   Yes   S, NULL   Null   —       1402   3397089   G   G   3440539   A   G   3436332   A   G   Yes   S, NULL   Null   —       1403   3401113   A   L   3444563   G   L   3440356   G   L   Yes   S, NULL   Null   —       1404   3401886   A   V   3445336   G   A   3441129   G   A   Yes   NS, C   P95078   protein kinase activity       1405   3404010   A   C   3447460   G   R   3443253   G   R   Yes   NS, NC   Q06861   DNA binding activity       1406   3405330   A   I   3448780   G   V   3444573   G   V   Yes   NS, C   O53300   —       1407   3409943   G   A   3453393   A   T   3449186   A   T   Yes   NS, NC   O53304   molecular_function                                                           unknown       1408   3410810   G   V   3454260   C   L   3450053   C   L   Yes   NS, C   O53304   molecular_function                                                           unknown       1409   3414061   C   Null   3457511   G   Null   3453304   G   null   No   nc, NULL   Null   —       1410   3417571   C   M   3461021   T   I   3456814   T   I   Yes   NS, NC   O05771   —       1411   3421176   G   G   3464626   A   E   3460424   A   E   Yes   NS, NC   O05775   hydrolase activity       1412   3423466   G   A   3466916   C   G   3462714   C   G   Yes   NS, C   P77909   enzyme activity       1413   3423862   C   E   3467312   G   D   3463110   G   D   Yes   NS, C   O05776   —       1414   3424012   G   A   3467462   C   A   3463260   C   A   Yes   S, NULL   Null   —       1415   3426715   C   S   3470165   T   N   3465963   T   N   Yes   NS, C   P96293   cytokinesis       1416   3430975   A   I   3474424   G   V   3470223   G   V   Yes   NS, C   O05783   ferredoxin-NADP                                                           reductase activity       1417   3431707   G   D   3475156   A   N   3470955   A   N   Yes   NS, NC   O05783   ferredoxin-NADP                                                           reductase activity       1418   3434037   G   V   3477486   A   I   3473285   A   I   Yes   NS, C   O05785   —       1419   3434151   T   Null   3477600   C   Null   3473399   C   null   No   nc, NULL   Null   —       1420   3435166   G   A   3478615   A   T   3474414   A   T   Yes   NS, NC   O05786   enzyme activity       1421   3436346   A   G   3479795   G   G   3475594   G   G   Yes   S, NULL   Null   —       1422   3436653   C   C   3480103   G   W   3475902   G   W   Yes   NS, NC   O05790   metabolism       1423   3437192   G   R   3480642   T   L   3476441   T   L   Yes   NS, NC   O05790   metabolism       1424   3437336   C   P   3480786   T   S   3476585   T   S   Yes   NS, NC   O05791   zinc ion binding activity       1425   3438022   A   T   3481472   G   A   3477271   G   A   Yes   NS, NC   P96354   peroxidase activity       1426   3438540   A   G   3481990   G   G   3477789   G   G   Yes   S, NULL   Null   —       1427   3442328   T   S   3488553   G   R   3484352   G   R   Yes   NS, NC   O07033   —       1428   3442459   A   Q   3488684   G   R   3484483   G   R   Yes   NS, NC   O07034   —       1429   3443112   G   Null   3489337   C   Null   3485136   C   null   No   nc, NULL   Null   —       1430   3445311   A   V   3491536   G   A   3487335   G   A   Yes   NS, C   O05798   —       1431   3446202   G   C   3492427   T   F   3488226   T   F   Yes   NS, NC   O05800   —       1432   3447457   C   G   3493682   A   V   3489481   A   null   Yes   NS, C   Not   —                                                       annotated       1433   3452190   G   T   3498415   A   I   3494214   A   I   Yes   NS, NC   P95194   ATP binding activity       1434   3456796   T   Null   3501684   C   Null   3497171   C   null   Yes   S, NULL   Null   —       1435   3459632   A   N   3504520   G   S   3500007   G   S   Yes   NS, C   P95188   lyase activity       1436   3460073   C   S   3504961   T   F   3500448   T   F   Yes   NS, NC   P95188   lyase activity       1437   3460112   T   L   3505000   C   P   3500487   C   P   Yes   NS, NC   P95188   lyase activity       1438   3460114   C   P   3505002   A   T   3500489   A   T   Yes   NS, NC   P95188   lyase activity       1439   3464200   C   Null   3509088   G   Null   3504575   G   null   No   nc, NULL   Null   —       1440   3464257   C   Q   3509145   A   H   3504632   A   H   Yes   NS, NC   P95184   —       1441   3465229   G   Q   3510117   T   K   3505604   T   K   Yes   NS, NC   P95182   —       1442   3466696   G   Null   3511584   T   Null   3507071   T   null   No   nc, NULL   Null   —       1443   3467191   C   G   3512079   A   G   3507566   A   G   Yes   S, NULL   Null   —       1444   3468833   T   N   3513721   C   N   3509208   C   N   Yes   S, NULL   Null   —       1445   3470134   T   G   3515022   C   G   3510509   C   G   Yes   S, NULL   Null   —       1446   3472676   T   N   3517564   C   N   3513051   C   N   Yes   S, NULL   Null   —       1447   3476153   G   A   3521041   A   T   3516528   A   T   Yes   NS, NC   P95173   electron transporter                                                           activity       1448   3478232   A   Y   3523120   T   F   3518607   T   F   Yes   NS, C   O86350   oxidative                                                           phosphorylation       1449   3480424   A   D   3525312   G   G   3520799   G   G   Yes   NS, NC   O53307   oxidative                                                           phosphorylation       1450   3480666   A   I   3525554   G   V   3521041   G   V   Yes   NS, C   O53307   oxidative                                                           phosphorylation       1451   3482095   T   A   3526983   A   A   3522470   A   A   Yes   S, NULL   Null   —       1452   3483661   T   E   3528549   G   D   3524036   G   D   Yes   NS, C   O53309   —       1453   3488207   G   L   3530952   C   V   3528588   C   V   Yes   NS, C   O53311   iron ion binding activity       1454   3489142   T   E   3531888   G   D   3529524   G   D   Yes   NS, C   O53313   transporter activity       1455   3491098   C   G   3533844   T   E   3531480   T   E   Yes   NS, NC   O53314   —       1456   3492231   G   V   3534977   C   V   3532613   C   V   Yes   S, NULL   Null   —       1457   3493545   C   R   3536291   T   W   3533927   T   W   Yes   NS, NC   O53318   —       1458   3497395   A   M   3540141   G   T   3537777   G   T   Yes   NS, NC   O53321   enzyme activity       1459   3499414   C   A   3542160   T   V   3539796   T   V   Yes   NS, C   O53324   metabolism       1460   3500015   C   L   3542761   G   L   3540397   G   L   Yes   S, NULL   Null   —       1461   3510233   G   A   3555696   A   V   3550616   A   V   Yes   NS, C   O53336   —       1462   3515180   T   Q   3560642   C   R   3555549   C   R   Yes   NS, NC   O53339   molecular_function                                                           unknown       1463   3519984   A   E   3565446   G   E   3560353   G   E   Yes   S, NULL   Null   —       1464   3522549   A   R   3568001   C   R   3562908   C   R   Yes   S, NULL   Null   —       1465   3526379   G   P   3571831   T   Q   3566738   T   Q   Yes   NS, NC   O53345   magnesium ion binding                                                           activity       1466   3528181   C   D   3573633   T   N   3568540   T   N   Yes   NS, NC   O53346   potassium channel                                                           activity       1467   3532503   G   A   3577955   A   V   3572862   A   V   Yes   NS, C   O53348   DNA binding activity       1468   3538731   T   N   3584187   C   D   3579093   C   null   Yes   NS, NC   O05859   proteolysis and                                                           peptidolysis       1469   3542388   C   A   3587844   T   V   3582750   T   V   Yes   NS, C   O05855   nucleic acid binding                                                           activity       1470   3544683   C   A   3590139   T   V   3585045   T   V   Yes   NS, C   O05854   —       1471   3545177   C   Null   3590633   G   Null   3585539   G   null   No   nc, NULL   Null   —       1472   3545178   G   Null   3590634   C   Null   3585540   C   null   No   nc, NULL   Null   —       1473   3549450   A   Q   3594848   G   Q   3589751   G   Q   Yes   S, NULL   Null   —       1474   3550026   A   R   3595424   G   R   3590327   G   R   Yes   S, NULL   Null   —       1475   3551995   T   N   3597393   C   D   3592296   C   D   Yes   NS, NC   O05846   ATP binding activity       1476   3556127   T   T   3601524   C   A   3596428   C   A   Yes   NS, NC   O05841   N-acetyltransferase                                                           activity       1477   3558424   A   H   3603821   G   R   3598725   G   R   Yes   NS, NC   P22487   3-phosphoshikimate 1-                                                           carboxyvinyltransferase                                                           activity       1478   3561226   A   L   3606623   G   L   3601527   G   L   Yes   S, NULL   Null   —       1479   3562541   A   C   3607938   G   R   3602842   G   R   Yes   NS, NC   O05875   electron transporter                                                           activity       1480   3563125   A   V   3608522   G   V   3603426   G   V   Yes   S, NULL   Null   —       1481   3566088   C   G   3611484   G   G   3606388   G   G   Yes   S, NULL   Null   —       1482   3569604   T   H   3615000   C   R   3609903   C   R   Yes   NS, NC   O05884   enzyme activity       1483   3577972   G   P   3623368   C   P   3618271   C   P   Yes   S, NULL   Null   —       1484   3578330   A   L   3623726   G   S   3618629   G   S   Yes   NS, NC   O05889   —       1485   3578950   A   A   3624346   C   A   3619249   C   A   Yes   S, NULL   Null   —       1486   3579086   C   G   3624482   T   D   3619385   T   D   Yes   NS, NC   O05889   —       1487   3579193   T   V   3624589   C   V   3619492   C   V   Yes   S, NULL   Null   —       1488   3579310   T   L   3624706   C   L   3619609   C   L   Yes   S, NULL   Null   —       1489   3583683   T   I   3629079   C   V   3623982   C   V   Yes   NS, C   O08364   adenosylhomocysteinase                                                           activity       1490   3592693   A   L   3638089   G   S   3632992   G   S   Yes   NS, NC   O86374   carbohydrate                                                           metabolism       1491   3601629   G   P   3647037   A   S   3641940   A   S   Yes   NS, NC   P96871   dTDP-4-                                                           dehydrorhamnose                                                           reductase activity       1492   3609075   G   S   3654483   A   N   3649386   A   N   Yes   NS, C   P96877   metabolism       1493   3609941   T   F   3655349   C   F   3650252   C   F   Yes   S, NULL   Null   —       1494   3612854   G   R   3658262   C   G   3653165   C   G   Yes   NS, NC   P96880   phospho-                                                           ribosylaminoimidazole                                                           carboxylase                                                           activity       1495   3615280   T   L   3660688   C   S   3655591   C   S   Yes   NS, NC   P96882   —       1496   3615970   T   N   3661378   C   D   3656280   C   D   Yes   NS, NC   P96884   biotin-apoprotein ligase                                                           activity       1497   3617992   C   A   3663400   T   V   3658302   T   V   Yes   NS, C   P96885   biotin carboxylase                                                           activity       1498   3619140   T   S   3664611   G   A   3659450   G   A   Yes   NS, NC   P96887   —       1499   3619961   A   D   3665432   G   G   3660271   G   G   Yes   NS, NC   P96888   thiosulfate                                                           sulfurtransferase                                                           activity       1500   3621718   T   H   3667189   C   H   3662028   C   H   Yes   S, NULL   Null   —       1501   3622087   C   G   3667558   T   G   3662397   T   G   Yes   S, NULL   Null   —       1502   3624565   T   A   3670036   C   A   3664875   C   A   Yes   S, NULL   Null   —       1503   3626758   A   V   3672229   G   A   3667068   G   A   Yes   NS, C   P96896   DNA binding activity       1504   3628943   T   C   3674414   G   G   3669253   G   G   Yes   NS, NC   P96898   metabolism       1505   3633454   A   M   3678925   G   V   3673764   G   V   Yes   NS, NC   P96901   nucleotide binding                                                           activity       1506   3633751   A   N   3679222   G   D   3674061   G   D   Yes   NS, NC   P96901   nucleotide binding                                                           activity       1507   3634474   G   E   3679945   A   K   3674784   A   K   Yes   NS, NC   P96901   nucleotide binding                                                           activity       1508   3636073   C   R   3681544   A   R   3676383   A   R   Yes   S, NULL   Null   —       1509   3639879   T   S   3685350   C   G   3680189   C   G   Yes   NS, NC   O65931   enzyme activity       1510   3641272   T   N   3686743   C   D   3681582   C   D   Yes   NS, NC   O07166   pseudouridylate                                                           synthase activity       1511   3644541   G   S   3690012   A   L   3684851   A   L   Yes   NS, NC   O53355   cytoplasm       1512   3645379   C   A   3690850   T   T   3685689   T   T   Yes   NS, NC   O53355   cytoplasm       1513   3648206   C   A   3693677   A   A   3688572   A   A   Yes   S, NULL   Null   —       1514   3650706   G   G   3696177   A   S   3691072   A   S   Yes   NS, NC   O53360   carbohydrate                                                           metabolism       1515   3652233   G   A   3697704   A   T   3692599   A   T   Yes   NS, NC   O53361   hydrolase activity       1516   3654880   G   Null   3700351   A   Null   3695243   A   null   No   nc, NULL   Null   —       1517   3657068   A   W   3702539   G   R   3697430   G   R   Yes   NS, NC   O53366   pyrimidine base                                                           metabolism       1518   3659623   A   V   3705094   G   V   3699985   G   V   Yes   S, NULL   Null   —       1519   3660007   A   E   3705478   G   E   3700369   G   E   Yes   S, NULL   Null   —       1520   3661401   G   E   3706872   C   D   3701763   C   D   Yes   NS, C   O53371   electron transporter                                                           activity       1521   3662101   C   Null   3707572   G   Null   3702463   G   null   No   nc, NULL   Null   —       1522   3662102   G   Null   3707573   C   Null   3702464   C   null   No   nc, NULL   Null   —       1523   3663410   A   A   3708884   G   A   3703775   G   A   Yes   S, NULL   Null   —       1524   3671821   T   L   3714568   C   L   3712186   C   L   Yes   S, NULL   Null   —       1525   3672930   T   D   3715677   C   D   3713295   C   D   Yes   S, NULL   Null   —       1526   3673148   A   V   3715895   G   V   3713513   G   V   Yes   S, NULL   Null   —       1527   3687716   G   T   3730462   A   I   3728072   A   null   Yes   NS, NC   O53393   carboxypeptidase A                                                           activity       1528   3693443   G   A   3740060   T   E   3732216   T   E   Yes   NS, NC   O53395   —       1529   3693692   A   V   3740309   C   G   3732465   C   G   Yes   NS, C   O53395   —       1530   3696063   A   T   3742525   G   T   3734759   G   T   Yes   S, NULL   Null   —       1531   3697083   G   Null   3743545   A   Null   3735779   A   null   No   nc, NULL   Null   —       1532   3699350   T   N   3745812   C   D   3738047   C   null   Yes   NS, NC   O50378   —       1533   3700460   C   W   3746922   T   W   3739156   T   null   Yes   S, NULL   Null   —       1534   3701886   G   A   3748349   C   G   3740583   C   null   Yes   NS, C   O50378   —       1535   3703453   A   S   3749916   G   P   3742150   G   null   Yes   NS, NC   O50378   —       1536   3703940   C   G   3750403   G   G   3742637   G   null   Yes   S, NULL   Null   —       1537   3703950   T   Y   3750413   A   F   3742647   A   null   Yes   NS, C   O50378   —       1538   3703954   C   G   3750417   T   S   3742651   T   null   Yes   NS, NC   O50378   —       1539   3704386   G   L   3750849   A   L   3743083   A   null   Yes   S, NULL   Null   —       1540   3704564   G   G   3751027   A   G   3743261   A   null   Yes   S, NULL   Null   —       1541   3704570   G   N   3751033   A   N   3743267   A   null   Yes   S, NULL   Null   —       1542   3706162   T   I   3752625   G   L   3744859   G   null   Yes   NS, C   O50378   —       1543   3706947   G   Null   3753410   T   Null   3745645   T   null   Yes   nc, NULL   Null   —       1544   3708970   A   Null   3755439   G   Null   3747674   G   null   No   nc, NULL   Null   —       1545   3711573   T   S   3758042   C   S   3750277   C   null   Yes   S, NULL   Null   —       1546   3715389   A   V   3761859   G   A   3754086   G   null   Yes   NS, C   O50379   —       1547   3717907   C   D   3764377   T   N   3756604   T   null   Yes   NS, NC   O50379   —       1548   3719141   C   A   3765611   G   A   3757838   G   null   Yes   S, NULL   Null   —       1549   3719324   T   Null   3765794   G   Null   3758021   G   null   Yes   S, NULL   Null   —       1550   3719936   G   G   3766406   C   G   3758633   C   null   Yes   S, NULL   Null   —       1551   3720790   G   Null   3767260   A   Null   3759487   A   null   No   nc, NULL   Null   —       1552   3722971   C   A   3769441   T   V   3761668   T   V   Yes   NS, C   O50383   —       1553   3724114   G   P   3770584   T   Q   3762811   T   Q   Yes   NS, NC   O50385   enzyme activity       1554   3724214   T   Null   3770684   C   Null   3762911   C   null   No   nc, NULL   Null   —       1555   3724771   A   L   3771241   G   L   3763468   G   L   Yes   S, NULL   Null   —       1556   3724938   G   R   3771408   T   R   3763635   T   R   Yes   S, NULL   Null   —       1557   3725154   C   I   3771624   A   I   3763851   A   I   Yes   S, NULL   Null   —       1558   3726142   A   Null   3772612   G   Null   3764839   G   null   No   nc, NULL   Null   —       1559   3729791   T   R   3776261   G   R   3768488   G   R   Yes   S, NULL   Null   —       1560   3733435   A   S   3779791   G   G   3772027   G   G   Yes   NS, NC   O50396   —       1561   3736194   A   S   3782550   G   S   3774786   G   S   Yes   S, NULL   Null   —       1562   3736445   T   R   3782801   G   R   3775037   G   R   Yes   S, NULL   Null   —       1563   3739586   G   G   3785942   A   R   3778178   A   R   Yes   NS, NC   O50400   molecular_function                                                           unknown       1564   3739673   G   V   3786029   A   I   3778265   A   I   Yes   NS, C   O50400   molecular_function                                                           unknown       1565   3742005   G   G   3788361   T   *   3780597   T   null   Yes   NS, TP   O50402   enzyme activity       1566   3746351   T   T   3792708   C   T   3784944   C   T   Yes   S, NULL   Null   —       1567   3747920   T   Y   3794277   C   C   3786513   C   null   Yes   NS, NC   O50408   —       1568   3752240   G   Null   3799953   A   Null   3790831   A   null   No   nc, NULL   Null   —       1569   3755845   C   A   3803582   G   G   3794460   G   G   Yes   NS, C   O50415   —       1570   3756614   A   L   3804273   G   P   3795151   G   P   Yes   NS, NC   Q11198   metabolism       1571   3760440   C   S   3808099   T   N   3798977   T   N   Yes   NS, C   Q11195   methyltransferase                                                           activity       1572   3763664   T   M   3811323   C   V   3802201   C   V   Yes   NS, NC   Q50730   integral to membrane       1573   3763966   A   V   3811625   G   A   3802503   G   A   Yes   NS, C   Q50730   integral to membrane       1574   3766395   A   I   3814054   G   I   3804932   G   I   Yes   S, NULL   Null   —       1575   3772351   A   H   3820010   G   R   3810888   G   R   Yes   NS, NC   Q50724   carbohydrate                                                           metabolism       1576   3773467   C   Null   3820835   G   Null   3811715   G   null   Yes   S, NULL   Null   —       1577   3774060   A   C   3821428   G   R   3812308   G   R   Yes   NS, NC   Q50723   —       1578   3777374   A   L   3824742   G   L   3815622   G   L   Yes   S, NULL   Null   —       1579   3783323   G   A   3830691   A   A   3821571   A   A   Yes   S, NULL   Null   —       1580   3795810   T   H   3848104   C   R   3834058   C   R   Yes   NS, NC   O06247   DNA binding activity       1581   3799589   C   A   3851883   A   S   3837836   A   S   Yes   NS, NC   O06250   molecular_function                                                           unknown       1582   3799590   C   A   3851884   T   A   3837837   T   A   Yes   S, NULL   Null   —       1583   3801054   T   T   3853348   C   A   3839301   C   A   Yes   NS, NC   O06251   —       1584   3804863   C   P   3857157   T   L   3843110   T   L   Yes   NS, NC   O06254   —       1585   3805949   T   Null   3858243   C   Null   3844196   C   null   No   nc, NULL   Null   —       1586   3812465   T   S   3864760   C   G   3850712   C   G   Yes   NS, NC   O06264   nucleotide binding                                                           activity       1587   3816846   A   D   3869141   C   A   3855093   C   A   Yes   NS, NC   O33354   transporter activity       1588   3817926   T   I   3870221   C   I   3856173   C   I   Yes   S, NULL   Null   —       1589   3818947   C   G   3871242   T   G   3857194   T   G   Yes   S, NULL   Null   —       1590   3823086   A   I   3875382   G   V   3861333   G   V   Yes   NS, C   O06321   —       1591   3824956   T   A   3877252   C   A   3863203   C   A   Yes   S, NULL   Null   —       1592   3826984   A   N   3879284   C   K   3865235   C   K   Yes   NS, NC   O06326   RNA binding activity       1593   3831379   C   V   3883679   G   V   3869630   G   V   Yes   S, NULL   Null   —       1594   3831382   G   G   3883682   T   G   3869633   T   G   Yes   S, NULL   Null   —       1595   3831386   A   T   3883686   G   A   3869637   G   A   Yes   NS, NC   O06331   —       1596   3831403   C   L   3883703   T   L   3869654   T   L   Yes   S, NULL   Null   —       1597   3831407   A   T   3883707   G   A   3869658   G   A   Yes   NS, NC   O06331   —       1598   3831541   C   G   3883841   T   G   3869792   T   G   Yes   S, NULL   Null   —       1599   3831611   A   I   3883911   G   V   3869862   G   V   Yes   NS, C   O06331   —       1600   3832059   G   E   3884359   A   K   3870310   A   K   Yes   NS, NC   Q50655   —       1601   3832094   T   I   3884394   C   I   3870345   C   I   Yes   S, NULL   Null   —       1602   3832393   G   G   3884693   C   A   3870644   C   A   Yes   NS, C   Q50655   —       1603   3832444   A   D   3884744   G   G   3870695   G   G   Yes   NS, NC   Q50655   —       1604   3832483   G   R   3884783   A   H   3870734   A   H   Yes   NS, NC   Q50655   —       1605   3832818   A   N   3885118   G   N   3880312   G   N   Yes   S, NULL   Null   —       1606   3835237   T   E   3887537   C   G   3882731   C   G   Yes   NS, NC   O06335   —       1607   3836573   C   W   3888873   G   C   3884067   G   C   Yes   NS, NC   O06336   nutrient reservoir                                                           activity       1608   3839628   A   V   3893286   G   A   3887122   G   A   Yes   NS, C   O06339   transporter activity       1609   3839818   A   F   3893476   G   L   3887312   G   L   Yes   NS, NC   O06339   transporter activity       1610   3840507   T   V   3894165   C   A   3888001   C   A   Yes   NS, C   O06340   —       1611   3842065   A   Null   3895723   C   Null   3889559   C   null   Yes   S, NULL   Null   —       1612   3842157   A   Null   3895815   G   Null   3889651   G   null   Yes   S, NULL   Null   —       1613   3844494   A   N   3898865   C   T   3892701   C   T   Yes   NS, C   O06342   enzyme activity       1614   3850113   A   E   3904486   G   E   3898322   G   E   Yes   S, NULL   Null   —       1615   3853581   A   R   3907954   G   G   3901790   G   G   Yes   NS, NC   O06351   —       1616   3854858   C   L   3909231   G   V   3903067   G   V   Yes   NS, C   O06353   alpha       1617   3858259   C   G   3912632   T   D   3906467   T   D   Yes   NS, NC   O53539   pathogenesis       1618   3865062   A   P   3919435   G   P   3913270   G   P   Yes   S, NULL   Null   —       1619   3867127   G   A   3921500   C   A   3915336   C   A   Yes   S, NULL   Null   —       1620   3868459   C   D   3922832   T   D   3916668   T   D   Yes   S, NULL   Null   —       1621   3869973   T   V   3924346   C   A   3918182   C   A   Yes   NS, C   O53550   acyl-CoA                                                           dehydrogenase activity       1622   3870019   A   Q   3924392   G   Q   3918228   G   Q   Yes   S, NULL   Null   —       1623   3874389   G   G   3928888   A   D   3922733   A   D   Yes   NS, NC   O53552   —       1624   3875932   A   G   3930377   C   G   3924213   C   G   Yes   S, NULL   Null   —       1625   3876018   G   G   3930463   A   D   3924299   A   D   Yes   NS, NC   O53552   —       1626   3908574   C   Null   3965355   T   Null   3957501   T   null   No   nc, NULL   Null   —       1627   3910673   C   L   3967454   T   L   3959600   T   L   Yes   S, NULL   Null   —       1628   3911467   T   S   3968248   C   S   3960394   C   S   Yes   S, NULL   Null   —       1629   3911833   A   T   3968614   G   T   3960760   G   T   Yes   S, NULL   Null   —       1630   3921125   A   L   3977906   G   L   3970052   G   L   Yes   S, NULL   Null   —       1631   3927536   A   H   3984317   G   H   3976463   G   H   Yes   S, NULL   Null   —       1632   3930860   C   V   3987641   T   M   3979787   T   M   Yes   NS, NC   P71853   metabolism       1633   3933129   T   S   3989910   G   A   3982056   G   A   Yes   NS, NC   P71850   metabolism       1634   3938113   G   R   3994894   A   W   3987040   A   null   Yes   NS, NC   P96837   —       1635   3939862   C   G   3996643   G   G   3988788   G   G   Yes   S, NULL   Null   —       1636   3942989   A   V   3999770   G   A   3991914   G   V   Yes   NS, C   P96841   metabolism       1637   3946062   A   N   4002843   C   T   3994987   C   T   Yes   NS, C   P96843   enzyme activity       1638   3947819   G   R   4004600   A   Q   3996744   A   Q   Yes   NS, NC   P96845   structural constituent of                                                           ribosome       1639   3948329   C   S   4005110   G   W   3997254   G   W   Yes   NS, NC   P96845   structural constituent of                                                           ribosome       1640   3951962   G   T   4008744   A   I   4000886   A   I   Yes   NS, NC   P96849   electron transport       1641   3952885   C   R   4009667   T   Q   4001809   T   Q   Yes   NS, NC   P96850   enzyme activity       1642   3955434   C   D   4012216   T   N   4004358   T   N   Yes   NS, NC   P96852   —       1643   3961924   A   N   4018706   G   D   4010848   G   D   Yes   NS, NC   P96858   —       1644   3964308   T   S   4021090   G   A   4013232   G   A   Yes   NS, NC   P96860   arsenite transporter                                                           activity       1645   3964705   G   A   4021486   T   E   4013628   T   E   Yes   NS, NC   P96861   RNA binding activity       1646   3964973   T   R   4021754   G   R   4013896   G   R   Yes   S, NULL   Null   —       1647   3965078   T   M   4021859   C   V   4014001   C   V   Yes   NS, NC   P96861   RNA binding activity       1648   3967982   C   A   4024763   T   T   4016905   T   T   Yes   NS, NC   P96864   isoprenoid biosynthesis       1649   3971967   G   A   4028749   A   T   4020891   A   T   Yes   NS, NC   O53571   DNA binding activity       1650   3972140   T   D   4028922   G   E   4021064   G   E   Yes   NS, C   O53571   DNA binding activity       1651   3973474   G   T   4030256   A   I   4022398   A   I   Yes   NS, NC   O53573   carbonate dehydratase                                                           activity       1652   3978123   G   S   4034905   A   N   4027047   A   N   Yes   NS, C   O06155   —       1653   3978196   A   Q   4034978   G   Q   4027120   G   Q   Yes   S, NULL   Null   —       1654   3981644   G   L   4038400   A   L   4030533   A   L   Yes   S, NULL   Null   —       1655   3989459   A   Null   4046215   G   Null   4038347   G   null   Yes   nc, NULL   Null   —       1656   3990280   C   G   4047036   A   V   4039168   A   V   Yes   NS, C   O06278   —       1657   3990684   C   G   4047440   A   G   4039572   A   G   Yes   S, NULL   Null   —       1658   3991234   A   G   4047990   G   G   4040122   G   G   Yes   S, NULL   Null   —       1659   3997767   G   G   4054634   A   G   4046877   A   G   Yes   S, NULL   Null   —       1660   3997999   T   K   4054866   C   K   4047109   C   K   Yes   S, NULL   Null   —       1661   3999048   G   A   4055915   A   V   4048158   A   V   Yes   NS, C   O06267   —       1662   3999546   A   Null   4056413   C   Null   4048656   C   null   No   nc, NULL   Null   —       1663   3999563   G   Null   4056430   A   Null   4048673   A   null   No   nc, NULL   Null   —       1664   3999617   C   Null   4056484   T   Null   4048727   T   null   Yes   nc, NULL   Null   —       1665   4004281   A   V   4067041   G   A   4059284   G   A   Yes   NS, C   O06380   serine                                                           carboxypeptidase                                                           activity       1666   4004389   A   V   4067149   G   A   4059392   G   A   Yes   NS, C   O06380   serine                                                           carboxypeptidase                                                           activity       1667   4006348   T   Null   4069108   C   Null   4061351   C   null   No   nc, NULL   Null   —       1668   4007724   T   Null   4070484   G   Null   4062727   G   null   No   nc, NULL   Null   —       1669   4013888   T   I   4076648   C   I   4068891   C   null   Yes   S, NULL   Null   —       1670   4015529   G   N   4078289   T   K   4070532   T   K   Yes   NS, NC   O06368   —       1671   4016100   T   E   4078860   C   G   4071103   C   G   Yes   NS, NC   O06367   —       1672   4017100   G   Null   4079860   C   Null   4072103   C   null   No   nc, NULL   Null   —       1673   4020748   T   I   4083508   C   I   4075752   C   I   Yes   S, NULL   Null   —       1674   4024907   T   V   4087667   C   V   4079911   C   V   Yes   S, NULL   Null   —       1675   4026295   C   P   4089055   T   L   4081299   T   L   Yes   NS, NC   O06359   nucleic acid binding                                                           activity       1676   4027898   T   H   4090658   C   H   4082902   C   H   Yes   S, NULL   Null   —       1677   4032641   C   E   4095292   T   E   4087553   T   E   Yes   S, NULL   Null   —       1678   4033932   A   A   4096583   G   A   4088843   G   A   Yes   S, NULL   Null   —       1679   4036406   A   L   4099057   G   P   4091317   G   null   Yes   NS, NC   O69628   —       1680   4037111   C   P   4099761   T   S   4092021   T   S   Yes   NS, NC   O69629   metabolism       1681   4039283   T   T   4101933   C   A   4094193   C   A   Yes   NS, NC   O69630   —       1682   4043080   C   G   4105730   T   E   4097990   T   E   Yes   NS, NC   O69634   transporter activity       1683   4043104   T   Q   4105754   C   R   4098014   C   R   Yes   NS, NC   O69634   transporter activity       1684   4044421   C   R   4107071   T   Q   4099331   T   Q   Yes   NS, NC   O69634   transporter activity       1685   4045320   A   E   4107970   G   G   4100230   G   G   Yes   NS, NC   O69635   enzyme activity       1686   4049776   C   V   4112426   T   I   4104686   T   I   Yes   NS, C   O69639   serine-type                                                           endopeptidase activity       1687   4054029   C   L   4116679   T   L   4108939   T   L   Yes   S, NULL   Null   —       1688   4054508   A   Null   4117158   C   Null   4109418   C   null   No   nc, NULL   Null   —       1689   4056593   C   D   4119243   T   D   4111501   T   D   Yes   S, NULL   Null   —       1690   4058330   G   Null   4120980   A   Null   4113238   A   null   No   nc, NULL   Null   —       1691   4059022   T   Null   4121672   C   Null   4113930   C   null   No   nc, NULL   Null   —       1692   4065667   G   Q   4128317   C   E   4120575   C   E   Yes   NS, NC   O69653   monooxygenase activity       1693   4066936   A   Null   4129586   C   Null   4121844   C   null   Yes   S, NULL   Null   —       1694   4068058   C   L   4130708   G   V   4122966   G   V   Yes   NS, C   O69657   —       1695   4072777   T   T   4135427   C   T   4127684   C   T   Yes   S, NULL   Null   —       1696   4073901   A   L   4136551   G   L   4128808   G   L   Yes   S, NULL   Null   —       1697   4075724   G   A   4138374   A   V   4130631   A   V   Yes   NS, C   O69664   glycerol kinase activity       1698   4076324   G   A   4138974   C   G   4131231   C   G   Yes   NS, C   O69664   glycerol kinase activity       1699   4077491   T   R   4140140   C   G   4132397   C   G   Yes   NS, NC   O69665   —       1700   4077846   C   R   4140495   A   R   4132752   A   R   Yes   S, NULL   Null   —       1701   4078038   C   I   4140687   G   M   4132944   G   M   Yes   NS, NC   O69666   —       1702   4078538   G   R   4141187   C   P   4133444   C   P   Yes   NS, NC   O69666   —       1703   4083085   G   Y   4145734   A   Y   4137991   A   Y   Yes   S, NULL   Null   —       1704   4091572   A   H   4154221   C   P   4146478   C   P   Yes   NS, NC   P96420   enzyme activity       1705   4092200   T   V   4154849   G   V   4147106   G   V   Yes   S, NULL   Null   —       1706   4093758   G   A   4156236   A   V   4148493   A   V   Yes   NS, C   O69678   DNA-directed DNA                                                           polymerase activity       1707   4094022   T   D   4156500   C   G   4148757   C   G   Yes   NS, NC   O69678   DNA-directed DNA                                                           polymerase activity       1708   4095038   A   S   4157575   G   G   4149891   G   G   Yes   NS, NC   O69679   ATP binding activity       1709   4095492   C   T   4158029   A   K   4150345   A   K   Yes   NS, NC   O69679   ATP binding activity       1710   4095821   G   P   4158358   A   P   4150674   A   P   Yes   S, NULL   Null   —       1711   4101540   A   Q   4164077   G   Q   4156393   G   Q   Yes   S, NULL   Null   —       1712   4107289   A   V   4169827   G   V   4162142   G   V   Yes   S, NULL   Null   —       1713   4108573   C   P   4171110   T   P   4163425   T   P   Yes   S, NULL   Null   —       1714   4109633   C   S   4172170   A   R   4164485   A   R   Yes   NS, NC   O69693   alcohol dehydrogenase                                                           activity       1715   4110670   A   M   4173207   G   V   4165522   G   V   Yes   NS, NC   O69694   —       1716   4113722   A   R   4176259   G   G   4168574   G   G   Yes   NS, NC   O69695   enzyme activity       1717   4116252   A   I   4178789   G   V   4171104   G   V   Yes   NS, C   O69696   S-adenosylmethionine-                                                           dependent                                                           methyltransferase                                                           activity       1718   4116549   T   S   4179086   C   P   4171401   C   P   Yes   NS, NC   O69696   S-adenosylmethionine-                                                           dependent                                                           methyltransferase                                                           activity       1719   4118314   C   G   4180851   G   G   4173166   G   G   Yes   S, NULL   Null   —       1720   4118737   A   F   4181274   G   F   4173589   G   F   Yes   S, NULL   Null   —       1721   4121062   T   A   4183599   C   A   4175914   C   A   Yes   S, NULL   Null   —       1722   4126515   A   R   4189052   C   R   4181367   C   R   Yes   S, NULL   Null   —       1723   4127210   A   C   4190913   G   R   4183228   G   R   Yes   NS, NC   O69707   molecular_function                                                           unknown       1724   4131476   A   C   4195179   G   C   4187494   G   C   Yes   S, NULL   Null   —       1725   4132036   T   A   4195739   C   A   4188054   C   A   Yes   S, NULL   Null   —       1726   4133484   G   Null   4197186   A   Null   4189502   A   null   Yes   nc, NULL   Null   —       1727   4133850   A   D   4197552   G   G   4189868   G   null   Yes   NS, NC   O69715   —       1728   4136514   G   T   4200217   A   M   4192532   A   M   Yes   NS, NC   O69720   —       1729   4138677   C   V   4202380   A   V   4194695   A   V   Yes   S, NULL   Null   —       1730   4141141   A   V   4204844   G   A   4197159   G   A   Yes   NS, C   O69725   —       1731   4144138   G   H   4207841   A   Y   4200156   A   Y   Yes   NS, C   O69728   —       1732   4144689   C   G   4208392   A   V   4200707   A   V   Yes   NS, C   O69728   —       1733   4147170   C   R   4210873   T   H   4203188   T   H   Yes   NS, NC   O69729   two-component sensor                                                           molecule activity       1734   4148468   C   Null   4212171   T   Null   4204486   T   null   No   nc, NULL   Null   —       1735   4151295   A   Null   4214998   C   Null   4207313   C   null   No   nc, NULL   Null   —       1736   4151778   C   A   4215481   G   P   4207796   G   P   Yes   NS, NC   P72037   —       1737   4152549   G   R   4216252   C   Null   4208567   C   R   Yes   nc, NULL   Null   —       1738   4153851   G   A   4217554   A   T   4209869   A   T   Yes   NS, NC   P72039   histidine biosynthesis       1739   4158142   T   A   4221844   C   A   4214159   C   A   Yes   S, NULL   Null   —       1740   4165765   C   Y   4229467   T   Y   4221782   T   Y   Yes   S, NULL   Null   —       1741   4167728   G   A   4231430   A   A   4223746   A   A   Yes   S, NULL   Null   —       1742   4168622   G   R   4232324   A   R   4224640   A   R   Yes   S, NULL   Null   —       1743   4169929   A   N   4233631   G   N   4225947   G   N   Yes   S, NULL   Null   —       1744   4172445   T   G   4236147   C   G   4228463   C   G   Yes   S, NULL   Null   —       1745   4176574   A   L   4240276   G   L   4232591   G   L   Yes   S, NULL   Null   —       1746   4176966   T   I   4240668   C   T   4232983   C   T   Yes   NS, NC   P72059   cell wall       1747   4179265   T   T   4242967   C   T   4235282   C   T   Yes   S, NULL   Null   —       1748   4180515   T   L   4244217   C   L   4236532   C   L   Yes   S, NULL   Null   —       1749   4182846   G   S   4246548   A   N   4238863   A   N   Yes   NS, C   P72030   cell wall       1750   4183159   T   V   4246861   C   V   4239176   C   V   Yes   S, NULL   Null   —       1751   4183941   C   A   4247643   A   E   4239958   A   E   Yes   NS, NC   P72030   cell wall       1752   4187131   T   I   4250833   C   T   4243148   C   T   Yes   NS, NC   P72062   hydrolase activity       1753   4187592   C   G   4251294   G   G   4243609   G   G   Yes   S, NULL   Null   —       1754   4195852   C   G   4259576   G   A   4251901   G   A   Yes   NS, C   O53579   enzyme activity       1755   4197772   A   V   4261496   G   A   4253821   G   A   Yes   NS, C   O53580   enzyme activity       1756   4199552   G   Null   4263276   A   Null   4255601   A   null   No   nc, NULL   Null   —       1757   4201999   C   G   4265723   G   G   4258048   G   G   Yes   S, NULL   Null   —       1758   4204131   C   V   4267855   T   I   4260180   T   I   Yes   NS, C   O53582   —       1759   4205624   A   A   4269348   G   A   4261673   G   A   Yes   S, NULL   Null   —       1760   4205660   G   D   4269384   T   E   4261709   T   E   Yes   NS, C   O53583   membrane       1761   4205879   G   R   4269603   A   R   4261928   A   R   Yes   S, NULL   Null   —       1762   4209847   G   Null   4273571   T   Null   4265896   T   null   No   nc, NULL   Null   —       1763   4214379   A   Null   4278103   G   Null   4270428   G   null   Yes   nc, NULL   Null   —       1764   4214597   C   Null   4278321   G   Null   4270646   G   null   No   nc, NULL   Null   —       1765   4215241   G   T   4278965   A   M   4271290   A   M   Yes   NS, NC   O07810   molecular_function                                                           unknown       1766   4217784   A   L   4281508   G   L   4273833   G   L   Yes   S, NULL   Null   —       1767   4220711   A   I   4284435   G   T   4276760   G   T   Yes   NS, NC   O07803   molecular_function                                                           unknown       1768   4222561   A   N   4286285   G   D   4278610   G   D   Yes   NS, NC   O07802   —       1769   4222603   A   T   4286327   G   A   4278652   G   A   Yes   NS, NC   O07802   —       1770   4223157   A   Y   4286881   G   C   4279206   G   C   Yes   NS, NC   O07801   —       1771   4223301   C   T   4287025   A   N   4279350   A   N   Yes   NS, C   O07801   —       1772   4223437   G   G   4287161   A   G   4279486   A   G   Yes   S, NULL   Null   —       1773   4223634   T   V   4287358   C   A   4279683   C   A   Yes   NS, C   O07801   —       1774   4226226   G   A   4289950   A   V   4282275   A   V   Yes   NS, C   O07800   membrane       1775   4226837   T   A   4290561   G   A   4282886   G   A   Yes   S, NULL   Null   —       1776   4227100   G   R   4290824   C   G   4283149   C   G   Yes   NS, NC   O07800   membrane       1777   4228368   A   A   4292092   C   A   4284417   C   A   Yes   S, NULL   Null   —       1778   4238583   C   L   4302307   A   L   4294632   A   L   Yes   S, NULL   Null   —       1779   4241120   A   D   4304844   C   E   4297169   C   E   Yes   NS, C   O07794   —       1780   4241350   A   T   4305074   G   T   4297399   G   T   Yes   S, NULL   Null   —       1781   4247232   A   Null   4310955   G   Null   4303280   G   null   No   nc, NULL   Null   —       1782   4249402   T   S   4313125   C   P   4305450   C   P   Yes   NS, NC   P96239   —       1783   4252596   T   H   4316319   C   R   4308644   C   R   Yes   NS, NC   P96235   —       1784   4252840   G   R   4316563   C   G   4308888   C   G   Yes   NS, NC   P96235   —       1785   4254698   G   Null   4318421   T   Null   4310746   T   null   Yes   nc, NULL   Null   —       1786   4257590   C   T   4321314   T   I   4313640   T   I   Yes   NS, NC   P17670   superoxide dismutase                                                           activity       1787   4259178   A   I   4322902   G   V   4315228   G   V   Yes   NS, C   P96229   molecular_function                                                           unknown       1788   4259279   A   A   4323003   G   A   4315329   G   A   Yes   S, NULL   Null   —       1789   4266055   A   Null   4329779   G   Null   4322105   G   null   Yes   nc, NULL   Null   —       1790   4266511   T   H   4330235   C   R   4322561   C   R   Yes   NS, NC   P96219   monooxygenase activity       1791   4270698   C   E   4334422   G   Q   4326748   G   Q   Yes   NS, NC   P96218   glutamate biosynthesis       1792   4272870   A   Null   4336594   C   Null   4328920   C   null   No   nc, NULL   Null   —       1793   4273741   C   A   4337465   T   V   4329791   T   V   Yes   NS, C   P96217   —       1794   4280361   T   V   4344038   C   A   4336363   C   A   Yes   NS, C   O69733   nucleotide binding                                                           activity       1795   4293145   A   K   4356822   G   E   4349146   G   E   Yes   NS, NC   O69742   —       1796   4293741   A   G   4357418   G   G   4349742   G   G   Yes   S, NULL   Null   —       1797   4294795   A   P   4358472   C   P   4350796   C   P   Yes   S, NULL   Null   —       1798   4300168   A   L   4363800   G   L   4356106   G   L   Yes   S, NULL   Null   —       1799   4301014   C   A   4364646   T   T   4356952   T   T   Yes   NS, NC   O05461   subtilase activity       1800   4304014   G   Y   4367646   A   Y   4359952   A   Y   Yes   S, NULL   Null   —       1801   4304489   G   P   4368121   A   L   4360427   A   L   Yes   NS, NC   O05459   —       1802   4307013   C   G   4370645   T   D   4362949   T   D   Yes   NS, NC   O05457   —       1803   4308186   C   A   4374225   T   T   4366529   T   T   Yes   NS, NC   O05453   —       1804   4310990   C   S   4377030   G   S   4369334   G   S   Yes   S, NULL   Null   —       1805   4313166   T   R   4379205   C   R   4371509   C   R   Yes   S, NULL   Null   —       1806   4314838   C   G   4380877   T   D   4373181   T   D   Yes   NS, NC   O05449   —       1807   4316253   C   V   4382293   T   I   4374597   T   I   Yes   NS, C   O05448   —       1808   4316561   C   G   4382601   T   D   4374905   T   D   Yes   NS, NC   O05448   —       1809   4316925   T   Null   4382965   C   Null   4375269   C   null   No   nc, NULL   Null   —       1810   4317617   G   Q   4383652   A   *   4375961   A   *   Yes   NS, TP   O05447   —       1811   4317969   G   Null   4384004   C   Null   4376313   C   null   No   nc, NULL   Null   —       1812   4319148   G   P   4385184   A   S   4377493   A   S   Yes   NS, NC   O05446   —       1813   4320218   C   A   4386254   G   P   4378563   G   P   Yes   NS, NC   O05445   —       1814   4320714   C   W   4386750   A   L   4379059   A   L   Yes   NS, NC   O05444   —       1815   4324427   C   V   4390463   T   M   4382772   T   M   Yes   NS, NC   O05441   —       1816   4324820   T   *   4390856   C   W   4383165   C   W   Yes   NS, TP   O05440   —       1817   4327799   T   L   4393835   C   L   4386144   C   L   Yes   S, NULL   Null   —       1818   4328171   C   R   4394207   G   G   4386516   G   R   Yes   NS, NC   O05436   —       1819   4328226   C   A   4394262   G   G   4386571   G   A   Yes   NS, C   O05436   —       1820   4329348   G   S   4395384   A   N   4387692   A   N   Yes   NS, C   O05436   —       1821   4329765   T   V   4395801   C   A   4388109   C   A   Yes   NS, C   O05436   —       1822   4331996   C   A   4398032   T   V   4390340   T   V   Yes   NS, C   O05435   pathogenesis       1823   4334624   T   S   4400660   C   S   4392968   G   A   Yes   S, NULL   Null   —       1824   4335857   G   G   4401894   A   D   4394201   A   D   Yes   NS, NC   P52214   thioredoxin reductase                                                           (NADPH) activity       1825   4339065   C   R   4405102   T   R   4397409   T   R   Yes   S, NULL   Null   —       1826   4341548   C   A   4407585   T   A   4399892   T   A   Yes   S, NULL   Null   —       1827   4342530   A   W   4408567   G   R   4400874   G   R   Yes   NS, NC   O53598   nucleic acid binding                                                           activity       1828   26940   G   Null   26959   C   Null   Null   Null   Null   No   Null, NC   Null   Null       1829   34028   C   Null   34044   T   Null   Null   Null   Null   No   Null, NC   Null   Null                 Table I: List of single nucleotide polymorphisms in  Mycobacaterium tuberculosis / M. bovis  BCG            Polymorphism ID: The ID by which the polymorphism can be identified            SNP Position: Position of the SNP in the respective genome            Base: The nucleotide occurring in the region of the polymorphism in the respective genome            AA: The aminoacid occurring in the region of the polymorphism in the respective genome            ORF: Indicates whether the polymorphism occurs in an open reading frame (yes) or not (no)            SNP type: Indicates the kind of SNP-S: synonymous SNP which codes for the same amino acid as the reference sequence; NS: non-synonymous SNP which codes for an aminoacid different from the reference sequence: C: conservative SNP coding for an aminoacid of the same family as the reference sequence: NC: nonconservative SNP coding for an aminoacid from a different family as the reference sequence            GO ID: The ID for the sequence in the gene ontology database            Putative function: The putative function of the gene in which the SNP occurs.             
 
         [0244]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE II 
               
             
             
               
                   
               
               
                   
               
               
                 List of insertion/deletions in  M. tuberculosis / M. bovis  BCG 
               
             
          
           
               
                   
                 BCG 
                 BCG 
                 H37Rv 
                 H37Rv 
                 CDC 
                 CDC 
                   
                   
                   
               
               
                 Polymorphism ID 
                 Start 
                 End 
                 start 
                 end 
                 start 
                 end 
                 ORF 
                 GO ID 
                 Putative Function 
               
               
                   
               
             
          
           
               
                 1830 
                 13233 
                 13234 
                 13233 
                 13235 
                 13233 
                 13235 
                 YES 
                 P71580 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1831 
                 24719 
                 24720 
                 24720 
                 24739 
                 13233 
                 13235 
                 YES 
                 P71590 
                 — 
               
               
                 1832 
                 28917 
                 28918 
                 28936 
                 28938 
                 13233 
                 13235 
                 YES 
                 P71594 
                 — 
               
               
                 1833 
                 30962 
                 30967 
                 30982 
                 30983 
                 13233 
                 13235 
                 YES 
                 P71596 
                 — 
               
               
                 1834 
                 42578 
                 42588 
                 42594 
                 42595 
                 13233 
                 13235 
                 YES 
                 P71697 
                 — 
               
               
                 1835 
                 71576 
                 71614 
                 71584 
                 71585 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1836 
                 79584 
                 79594 
                 79555 
                 79556 
                 13233 
                 13235 
                 YES 
                 O53616 
                 RNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1837 
                 82490 
                 82491 
                 82452 
                 82454 
                 13233 
                 13235 
                 YES 
                 O53618 
                 nucleotide binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1838 
                 125870 
                 125872 
                 125832 
                 125833 
                 13233 
                 13235 
                 YES 
                 Q10900 
                 magnesium ion 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 binding activity 
               
               
                 1839 
                 131213 
                 131215 
                 131174 
                 131175 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1840 
                 138784 
                 138786 
                 138744 
                 138745 
                 13233 
                 13235 
                 YES 
                 O53637 
                 peroxidase activity 
               
               
                 1841 
                 139598 
                 139600 
                 139557 
                 139558 
                 13233 
                 13235 
                 YES 
                 O53637 
                 peroxidase activity 
               
               
                 1842 
                 147495 
                 147496 
                 147453 
                 147455 
                 13233 
                 13235 
                 YES 
                 O07170 
                 translation 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 elongation factor 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1843 
                 147853 
                 147854 
                 147812 
                 147814 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1844 
                 150079 
                 150080 
                 150039 
                 150067 
                 13233 
                 13235 
                 YES 
                 O07174 
                 — 
               
               
                 1845 
                 150906 
                 151077 
                 150893 
                 150894 
                 13233 
                 13235 
                 YES 
                 O07174 
                 — 
               
               
                 1846 
                 162346 
                 162347 
                 162153 
                 162155 
                 13233 
                 13235 
                 YES 
                 P96811 
                 enzyme activity 
               
               
                 1847 
                 162451 
                 162453 
                 162259 
                 162260 
                 13233 
                 13235 
                 YES 
                 P96811 
                 enzyme activity 
               
               
                 1848 
                 162694 
                 162695 
                 162501 
                 162503 
                 13233 
                 13235 
                 YES 
                 P96811 
                 enzyme activity 
               
               
                 1849 
                 194495 
                 194498 
                 194303 
                 194304 
                 13233 
                 13235 
                 YES 
                 O07410 
                 transcription factor 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1850 
                 208509 
                 208510 
                 208315 
                 208322 
                 13233 
                 13235 
                 YES 
                 O07420 
                 — 
               
               
                 1851 
                 223943 
                 223945 
                 223749 
                 223750 
                 13233 
                 13235 
                 YES 
                 O07436 
                 — 
               
               
                 1852 
                 230770 
                 230772 
                 230575 
                 230576 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1853 
                 234690 
                 234693 
                 234494 
                 234495 
                 13233 
                 13235 
                 YES 
                 O53648 
                 — 
               
               
                 1854 
                 257984 
                 258014 
                 257786 
                 257787 
                 13233 
                 13235 
                 YES 
                 P96397 
                 acyl-CoA 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1855 
                 264979 
                 264980 
                 264752 
                 266645 
                 13233 
                 13235 
                 YES 
                 P96403, P96405 
                 — 
               
               
                 1856 
                 265066 
                 265068 
                 266741 
                 266742 
                 13233 
                 13235 
                 YES 
                 P96405 
                 metabolism 
               
               
                 1857 
                 291957 
                 291959 
                 293631 
                 293632 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1858 
                 331998 
                 331999 
                 333671 
                 333673 
                 13233 
                 13235 
                 YES 
                 P56877 
                 — 
               
               
                 1859 
                 332977 
                 335748 
                 334651 
                 334652 
                 13233 
                 13235 
                 YES 
                 P56877 
                 — 
               
               
                 1860 
                 336706 
                 336707 
                 335600 
                 335657 
                 13233 
                 13235 
                 YES 
                 P56877 
                 — 
               
               
                 1861 
                 336884 
                 336885 
                 335844 
                 335863 
                 13233 
                 13235 
                 YES 
                 P56877 
                 — 
               
               
                 1862 
                 338180 
                 338181 
                 337158 
                 337168 
                 13233 
                 13235 
                 YES 
                 O53684 
                 — 
               
               
                 1863 
                 339540 
                 339541 
                 338527 
                 338537 
                 13233 
                 13235 
                 YES 
                 O53684 
                 — 
               
               
                 1864 
                 363810 
                 363856 
                 362806 
                 362807 
                 13233 
                 13235 
                 YES 
                 O07224 
                 intracellular 
               
               
                 1865 
                 369162 
                 369163 
                 368113 
                 368129 
                 13233 
                 13235 
                 YES 
                 O07231 
                 tRNA ligase activity 
               
               
                 1866 
                 370799 
                 370800 
                 369765 
                 369767 
                 13233 
                 13235 
                 YES 
                 O07231 
                 tRNA ligase activity 
               
               
                 1867 
                 374314 
                 374315 
                 373281 
                 373283 
                 13233 
                 13235 
                 YES 
                 O07232 
                 — 
               
               
                 1868 
                 416214 
                 416215 
                 415182 
                 415184 
                 13233 
                 13235 
                 YES 
                 O06296 
                 — 
               
               
                 1869 
                 425351 
                 425353 
                 424320 
                 424321 
                 13233 
                 13235 
                 YES 
                 O06303 
                 — 
               
               
                 1870 
                 425821 
                 425824 
                 424789 
                 424790 
                 13233 
                 13235 
                 YES 
                 O06304 
                 — 
               
               
                 1871 
                 428391 
                 428392 
                 427357 
                 427373 
                 13233 
                 13235 
                 YES 
                 O06304 
                 — 
               
               
                 1872 
                 482549 
                 482550 
                 481528 
                 481530 
                 13233 
                 13235 
                 YES 
                 P95211 
                 membrane 
               
               
                 1873 
                 488117 
                 488119 
                 487097 
                 487098 
                 13233 
                 13235 
                 YES 
                 O86335 
                 enzyme activity 
               
               
                 1874 
                 570941 
                 570942 
                 569920 
                 569961 
                 13233 
                 13235 
                 YES 
                 Q11146 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 1875 
                 578459 
                 578500 
                 577494 
                 577495 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1876 
                 581835 
                 581956 
                 580812 
                 580813 
                 13233 
                 13235 
                 YES 
                 Q11156 
                 two-component 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 response regulator 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1877 
                 612063 
                 612064 
                 610910 
                 610912 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1878 
                 624447 
                 624522 
                 623295 
                 623296 
                 13233 
                 13235 
                 YES 
                 O06398 
                 — 
               
               
                 1879 
                 624655 
                 624665 
                 623419 
                 623420 
                 13233 
                 13235 
                 YES 
                 O06398 
                 — 
               
               
                 1880 
                 625594 
                 625596 
                 624349 
                 624350 
                 13233 
                 13235 
                 YES 
                 O06398 
                 — 
               
               
                 1881 
                 641609 
                 641610 
                 640363 
                 640365 
                 13233 
                 13235 
                 YES 
                 O06415 
                 — 
               
               
                 1882 
                 664431 
                 664432 
                 663186 
                 663188 
                 13233 
                 13235 
                 YES 
                 O53767 
                 ribonucleoside- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 diphosphate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 reductase activity 
               
               
                 1883 
                 669950 
                 669952 
                 668706 
                 668707 
                 13233 
                 13235 
                 YES 
                 O53772 
                 monooxygenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1884 
                 690039 
                 690041 
                 688794 
                 688795 
                 13233 
                 13235 
                 YES 
                 O07788 
                 pathogenesis 
               
               
                 1885 
                 693138 
                 693140 
                 691892 
                 691893 
                 13233 
                 13235 
                 YES 
                 O07786 
                 pathogenesis 
               
               
                 1886 
                 713437 
                 713439 
                 712190 
                 712191 
                 13233 
                 13235 
                 YES 
                 O07759, O07758 
                 — 
               
               
                 1887 
                 723680 
                 723681 
                 722432 
                 722434 
                 13233 
                 13235 
                 YES 
                 P96920 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1888 
                 731330 
                 731331 
                 730083 
                 730093 
                 13233 
                 13235 
                 YES 
                 P96923 
                 — 
               
               
                 1889 
                 743870 
                 744394 
                 742632 
                 742633 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1890 
                 800911 
                 800912 
                 799140 
                 799142 
                 13233 
                 13235 
                 YES 
                 P95044 
                 — 
               
               
                 1891 
                 804268 
                 804309 
                 802498 
                 802499 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1892 
                 832699 
                 832702 
                 830875 
                 830876 
                 13233 
                 13235 
                 YES 
                 O53802 
                 — 
               
               
                 1893 
                 838696 
                 838697 
                 836870 
                 836919 
                 13233 
                 13235 
                 YES 
                 O53809 
                 — 
               
               
                 1894 
                 839071 
                 839072 
                 837293 
                 837342 
                 13233 
                 13235 
                 YES 
                 O53809 
                 — 
               
               
                 1895 
                 839638 
                 839767 
                 837908 
                 837909 
                 13233 
                 13235 
                 YES 
                 O53809 
                 — 
               
               
                 1896 
                 841026 
                 841185 
                 839098 
                 839099 
                 13233 
                 13235 
                 YES 
                 O53810 
                 — 
               
               
                 1897 
                 841398 
                 841494 
                 839302 
                 839303 
                 13233 
                 13235 
                 YES 
                 O53810 
                 — 
               
               
                 1898 
                 841688 
                 841689 
                 839487 
                 839497 
                 13233 
                 13235 
                 YES 
                 O53810 
                 — 
               
               
                 1899 
                 856450 
                 856451 
                 854258 
                 854260 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1900 
                 877025 
                 877028 
                 874834 
                 874835 
                 13233 
                 13235 
                 YES 
                 P71834, P71835 
                 — 
               
               
                 1901 
                 881931 
                 881932 
                 879738 
                 879740 
                 13233 
                 13235 
                 YES 
                 P71838 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1902 
                 890037 
                 890038 
                 887845 
                 887847 
                 13233 
                 13235 
                 YES 
                 O07268 
                 cytoplasm 
               
               
                 1903 
                 927816 
                 927891 
                 926984 
                 926985 
                 13233 
                 13235 
                 YES 
                 O53844 
                 — 
               
               
                 1904 
                 928822 
                 928823 
                 927918 
                 927928 
                 13233 
                 13235 
                 YES 
                 O53845 
                 calcium ion binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1905 
                 928975 
                 928976 
                 928080 
                 928215 
                 13233 
                 13235 
                 YES 
                 O53845 
                 calcium ion binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1906 
                 936197 
                 936204 
                 935446 
                 935447 
                 13233 
                 13235 
                 YES 
                 O53850 
                 cell wall 
               
               
                 1907 
                 953566 
                 953567 
                 952809 
                 952811 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1908 
                 961024 
                 961025 
                 960268 
                 960309 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1909 
                 963656 
                 963657 
                 962953 
                 962955 
                 13233 
                 13235 
                 YES 
                 O53876 
                 Mo-molybdopterin 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 cofactor 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 biosynthesis 
               
               
                 1910 
                 965541 
                 965542 
                 964839 
                 965070 
                 13233 
                 13235 
                 YES 
                 O53879 
                 — 
               
               
                 1911 
                 968900 
                 968910 
                 968438 
                 968439 
                 13233 
                 13235 
                 YES 
                 O53884 
                 — 
               
               
                 1912 
                 969448 
                 969449 
                 968977 
                 968981 
                 13233 
                 13235 
                 YES 
                 O53884 
                 — 
               
               
                 1913 
                 977362 
                 977363 
                 976894 
                 976896 
                 13233 
                 13235 
                 YES 
                 Q10540 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1914 
                 1010671 
                 1010673 
                 1010204 
                 1010205 
                 13233 
                 13235 
                 YES 
                 O05900 
                 — 
               
               
                 1915 
                 1032449 
                 1032450 
                 1031981 
                 1031983 
                 13233 
                 13235 
                 YES 
                 O05917 
                 — 
               
               
                 1916 
                 1039551 
                 1039553 
                 1039084 
                 1039085 
                 13233 
                 13235 
                 YES 
                 O05871 
                 protein kinase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1917 
                 1041920 
                 1041922 
                 1041452 
                 1041453 
                 13233 
                 13235 
                 YES 
                 P95302 
                 nucleotide binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1918 
                 1064550 
                 1064551 
                 1064081 
                 1064110 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1919 
                 1087886 
                 1087887 
                 1087445 
                 1087447 
                 13233 
                 13235 
                 YES 
                 O86319 
                 acyl-CoA 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1920 
                 1090629 
                 1090631 
                 1090189 
                 1090190 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1921 
                 1131681 
                 1131683 
                 1131228 
                 1131229 
                 13233 
                 13235 
                 YES 
                 O05597 
                 — 
               
               
                 1922 
                 1135355 
                 1135356 
                 1134901 
                 1134907 
                 13233 
                 13235 
                 YES 
                 P96384 
                 membrane 
               
               
                 1923 
                 1165969 
                 1165971 
                 1165520 
                 1165521 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1924 
                 1169165 
                 1169167 
                 1168715 
                 1168716 
                 13233 
                 13235 
                 YES 
                 O86321 
                 — 
               
               
                 1925 
                 1173288 
                 1173289 
                 1172837 
                 1172839 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1926 
                 1189124 
                 1189125 
                 1188674 
                 1188678 
                 13233 
                 13235 
                 YES 
                 O53415 
                 — 
               
               
                 1927 
                 1189603 
                 1189622 
                 1189156 
                 1189157 
                 13233 
                 13235 
                 YES 
                 O53415 
                 — 
               
               
                 1928 
                 1189661 
                 1189662 
                 1189196 
                 1189200 
                 13233 
                 13235 
                 YES 
                 O53415 
                 — 
               
               
                 1929 
                 1191462 
                 1191463 
                 1191000 
                 1191010 
                 13233 
                 13235 
                 YES 
                 O53416 
                 — 
               
               
                 1930 
                 1191817 
                 1192525 
                 1191364 
                 1191365 
                 13233 
                 13235 
                 YES 
                 O53416 
                 — 
               
               
                 1931 
                 1192629 
                 1192812 
                 1191459 
                 1191460 
                 13233 
                 13235 
                 YES 
                 O53416 
                 — 
               
               
                 1932 
                 1214392 
                 1214393 
                 1213030 
                 1213049 
                 13233 
                 13235 
                 YES 
                 O53435 
                 — 
               
               
                 1933 
                 1214589 
                 1214590 
                 1213245 
                 1213255 
                 13233 
                 13235 
                 YES 
                 O53435 
                 — 
               
               
                 1934 
                 1214840 
                 1214844 
                 1213505 
                 1213506 
                 13233 
                 13235 
                 YES 
                 O53435 
                 — 
               
               
                 1935 
                 1215028 
                 1215074 
                 1213690 
                 1213691 
                 13233 
                 13235 
                 YES 
                 O53435 
                 — 
               
               
                 1936 
                 1219617 
                 1219618 
                 1218234 
                 1218244 
                 13233 
                 13235 
                 YES 
                 O53439 
                 — 
               
               
                 1937 
                 1231791 
                 1231792 
                 1230417 
                 1230419 
                 13233 
                 13235 
                 YES 
                 O53449 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1938 
                 1274621 
                 1274623 
                 1273248 
                 1273249 
                 13233 
                 13235 
                 YES 
                 O06545 
                 membrane 
               
               
                 1939 
                 1300681 
                 1300683 
                 1299307 
                 1299308 
                 13233 
                 13235 
                 YES 
                 O50424 
                 — 
               
               
                 1940 
                 1306903 
                 1306904 
                 1305528 
                 1305643 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1941 
                 1314587 
                 1314589 
                 1313336 
                 1313337 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1942 
                 1341420 
                 1341421 
                 1340168 
                 1340182 
                 13233 
                 13235 
                 YES 
                 O05298 
                 — 
               
               
                 1943 
                 1358664 
                 1358665 
                 1357415 
                 1357421 
                 13233 
                 13235 
                 YES 
                 O05315 
                 — 
               
               
                 1944 
                 1367083 
                 1367086 
                 1365839 
                 1365840 
                 13233 
                 13235 
                 YES 
                 O06291 
                 serine-type 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 endopeptidase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1945 
                 1404177 
                 1404178 
                 1402931 
                 1405929 
                 13233 
                 13235 
                 YES 
                 Q11063, Q11061 
                 — 
               
               
                 1946 
                 1407255 
                 1407256 
                 1409016 
                 1409018 
                 13233 
                 13235 
                 YES 
                 Q11058 
                 monooxygenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1947 
                 1439690 
                 1439691 
                 1441542 
                 1441686 
                 13233 
                 13235 
                 YES 
                 Q10614 
                 enzyme activity 
               
               
                 1948 
                 1441478 
                 1441519 
                 1443483 
                 1443484 
                 13233 
                 13235 
                 YES 
                 Q10616 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1949 
                 1466163 
                 1466164 
                 1468112 
                 1468115 
                 13233 
                 13235 
                 YES 
                 Q10620 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1950 
                 1475063 
                 1475064 
                 1477025 
                 1477027 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1951 
                 1539986 
                 1539987 
                 1541949 
                 1543298 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1952 
                 1540483 
                 1540485 
                 1543804 
                 1543805 
                 13233 
                 13235 
                 YES 
                 P71799 
                 — 
               
               
                 1953 
                 1543150 
                 1543152 
                 1546470 
                 1546471 
                 13233 
                 13235 
                 YES 
                 P71801 
                 sulfotransferase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1954 
                 1569167 
                 1569168 
                 1572486 
                 1572849 
                 13233 
                 13235 
                 YES 
                 P71664 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1955 
                 1608954 
                 1608976 
                 1612645 
                 1612646 
                 13233 
                 13235 
                 YES 
                 O06823 
                 — 
               
               
                 1956 
                 1627336 
                 1627337 
                 1630987 
                 1631015 
                 13233 
                 13235 
                 YES 
                 O06810 
                 — 
               
               
                 1957 
                 1628863 
                 1628891 
                 1632541 
                 1632542 
                 13233 
                 13235 
                 YES 
                 O06810 
                 — 
               
               
                 1958 
                 1632753 
                 1632882 
                 1636167 
                 1636168 
                 13233 
                 13235 
                 YES 
                 O06808 
                 — 
               
               
                 1959 
                 1632905 
                 1632909 
                 1636181 
                 1636182 
                 13233 
                 13235 
                 YES 
                 O06808 
                 — 
               
               
                 1960 
                 1633457 
                 1633467 
                 1636730 
                 1636731 
                 13233 
                 13235 
                 YES 
                 O06808 
                 — 
               
               
                 1961 
                 1689986 
                 1689987 
                 1693238 
                 1693240 
                 13233 
                 13235 
                 YES 
                 P71783 
                 — 
               
               
                 1962 
                 1737536 
                 1737538 
                 1753521 
                 1753522 
                 13233 
                 13235 
                 YES 
                 Q10777 
                 enzyme activity 
               
               
                 1963 
                 1738035 
                 1738037 
                 1754019 
                 1754020 
                 13233 
                 13235 
                 YES 
                 Q10777, Q10776 
                 — 
               
               
                 1964 
                 1744186 
                 1744191 
                 1760169 
                 1760170 
                 13233 
                 13235 
                 YES 
                 Q10761 
                 succinate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1965 
                 1745810 
                 1747954 
                 1761789 
                 1761790 
                 13233 
                 13235 
                 YES 
                 Q10773 
                 membrane 
               
               
                 1966 
                 1754245 
                 1754246 
                 1768071 
                 1768868 
                 13233 
                 13235 
                 YES 
                 Q10768 
                 alpha-amylase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1967 
                 1765829 
                 1765830 
                 1780461 
                 1780463 
                 13233 
                 13235 
                 YES 
                 O06615 
                 — 
               
               
                 1968 
                 1765952 
                 1765954 
                 1780585 
                 1780586 
                 13233 
                 13235 
                 YES 
                 O06615 
                 — 
               
               
                 1969 
                 1837548 
                 1837549 
                 1852180 
                 1852182 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1970 
                 1850305 
                 1850327 
                 1864938 
                 1864939 
                 13233 
                 13235 
                 YES 
                 P94986 
                 — 
               
               
                 1971 
                 1879687 
                 1879698 
                 1894299 
                 1894300 
                 13233 
                 13235 
                 YES 
                 O53916 
                 nucleotide binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1972 
                 1892915 
                 1892916 
                 1907517 
                 1907558 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1973 
                 1900884 
                 1900887 
                 1915542 
                 1915543 
                 13233 
                 13235 
                 YES 
                 O33192 
                 — 
               
               
                 1974 
                 1914068 
                 1914069 
                 1928724 
                 1928726 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1975 
                 1930724 
                 1930725 
                 1945381 
                 1945383 
                 13233 
                 13235 
                 YES 
                 P71976 
                 — 
               
               
                 1976 
                 1941012 
                 1941053 
                 1955670 
                 1955671 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1977 
                 1953648 
                 1953650 
                 1968249 
                 1968250 
                 13233 
                 13235 
                 YES 
                 O33271 
                 — 
               
               
                 1978 
                 1967611 
                 1967752 
                 1982211 
                 1982212 
                 13233 
                 13235 
                 YES 
                 O65937 
                 — 
               
               
                 1979 
                 1968448 
                 1968449 
                 1982898 
                 1982967 
                 13233 
                 13235 
                 YES 
                 O65937 
                 — 
               
               
                 1980 
                 1968664 
                 1968665 
                 1983192 
                 1983261 
                 13233 
                 13235 
                 YES 
                 O65937 
                 — 
               
               
                 1981 
                 1983171 
                 1983172 
                 1992328 
                 1992330 
                 13233 
                 13235 
                 YES 
                 O06794 
                 — 
               
               
                 1982 
                 1985312 
                 1985313 
                 1994470 
                 1994472 
                 13233 
                 13235 
                 YES 
                 O06795 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 1983 
                 1992126 
                 1992145 
                 2001684 
                 2001685 
                 13233 
                 13235 
                 YES 
                 O06801 
                 — 
               
               
                 1984 
                 2016682 
                 2016683 
                 2026222 
                 2026231 
                 13233 
                 13235 
                 YES 
                 O86373 
                 — 
               
               
                 1985 
                 2051905 
                 2051915 
                 2061448 
                 2061449 
                 13233 
                 13235 
                 YES 
                 Q50615 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1986 
                 2064977 
                 2064978 
                 2074511 
                 2074614 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1987 
                 2079195 
                 2079196 
                 2088841 
                 2088979 
                 13233 
                 13235 
                 YES 
                 Q50594 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1988 
                 2080613 
                 2080626 
                 2090406 
                 2090407 
                 13233 
                 13235 
                 YES 
                 Q50593 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 1989 
                 2084192 
                 2084193 
                 2093973 
                 2093975 
                 13233 
                 13235 
                 YES 
                 P95165 
                 phosphogluconate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (decarboxylating) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1990 
                 2085136 
                 2085137 
                 2094918 
                 2094925 
                 13233 
                 13235 
                 YES 
                 P95165 
                 phosphogluconate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (decarboxylating) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1991 
                 2087040 
                 2087041 
                 2096828 
                 2096830 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1992 
                 2093386 
                 2093387 
                 2103175 
                 2103177 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1993 
                 2099733 
                 2099735 
                 2109523 
                 2109524 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 1994 
                 2116913 
                 2116915 
                 2126702 
                 2126703 
                 13233 
                 13235 
                 YES 
                 O07753 
                 transporter activity 
               
               
                 1995 
                 2123684 
                 2123700 
                 2133472 
                 2133473 
                 13233 
                 13235 
                 YES 
                 O07748 
                 — 
               
               
                 1996 
                 2127747 
                 2127758 
                 2137520 
                 2137521 
                 13233 
                 13235 
                 YES 
                 O07744 
                 — 
               
               
                 1997 
                 2133043 
                 2133044 
                 2142806 
                 2142808 
                 13233 
                 13235 
                 YES 
                 O07737 
                 alcohol 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1998 
                 2133758 
                 2133760 
                 2143522 
                 2143523 
                 13233 
                 13235 
                 YES 
                 O07737 
                 alcohol 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1999 
                 2136332 
                 2136378 
                 2146095 
                 2146096 
                 13233 
                 13235 
                 YES 
                 O07733 
                 — 
               
               
                 2000 
                 2151627 
                 2151629 
                 2161345 
                 2161346 
                 13233 
                 13235 
                 YES 
                 O07718 
                 enzyme activity 
               
               
                 2001 
                 2153548 
                 2153549 
                 2163265 
                 2163278 
                 13233 
                 13235 
                 YES 
                 O07716 
                 enzyme activity 
               
               
                 2002 
                 2153668 
                 2154142 
                 2163397 
                 2163398 
                 13233 
                 13235 
                 YES 
                 O07716 
                 enzyme activity 
               
               
                 2003 
                 2154541 
                 2154542 
                 2163787 
                 2163847 
                 13233 
                 13235 
                 YES 
                 O07716 
                 enzyme activity 
               
               
                 2004 
                 2156236 
                 2156602 
                 2165551 
                 2165552 
                 13233 
                 13235 
                 YES 
                 O07716 
                 enzyme activity 
               
               
                 2005 
                 2160449 
                 2160451 
                 2168813 
                 2168814 
                 13233 
                 13235 
                 YES 
                 O53960 
                 — 
               
               
                 2006 
                 2184230 
                 2184231 
                 2192593 
                 2192595 
                 13233 
                 13235 
                 YES 
                 P95275 
                 electron transport 
               
               
                 2007 
                 2199225 
                 2199227 
                 2207589 
                 2207590 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2008 
                 2254439 
                 2254440 
                 2270521 
                 2270531 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2009 
                 2260638 
                 2260639 
                 2276722 
                 2276724 
                 13233 
                 13235 
                 YES 
                 O53475 
                 nucleoside 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 metabolism 
               
               
                 2010 
                 2312077 
                 2312079 
                 2328162 
                 2328163 
                 13233 
                 13235 
                 YES 
                 Q10680 
                 vitamin B12 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 biosynthesis 
               
               
                 2011 
                 2313772 
                 2313774 
                 2329856 
                 2329857 
                 13233 
                 13235 
                 YES 
                 Q10671 
                 porphyrin 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 biosynthesis 
               
               
                 2012 
                 2313988 
                 2313989 
                 2330071 
                 2332091 
                 13233 
                 13235 
                 YES 
                 Q10671, Q10683 
                 — 
               
               
                 2013 
                 2320088 
                 2320092 
                 2338200 
                 2338201 
                 13233 
                 13235 
                 YES 
                 Q10689 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 2014 
                 2324539 
                 2324551 
                 2342648 
                 2342649 
                 13233 
                 13235 
                 YES 
                 Q10692 
                 — 
               
               
                 2015 
                 2329456 
                 2329457 
                 2347554 
                 2347595 
                 13233 
                 13235 
                 YES 
                 Q10699 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2016 
                 2339127 
                 2339128 
                 2357282 
                 2357286 
                 13233 
                 13235 
                 YES 
                 Q10707 
                 — 
               
               
                 2017 
                 2339871 
                 2339873 
                 2358029 
                 2358030 
                 13233 
                 13235 
                 YES 
                 Q10707, Q9ZAE2 
                 — 
               
               
                 2018 
                 2347255 
                 2347256 
                 2365412 
                 2366761 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2019 
                 2349048 
                 2349049 
                 2368563 
                 2368565 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2020 
                 2352985 
                 2352986 
                 2372501 
                 2372542 
                 13233 
                 13235 
                 YES 
                 O33247 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2021 
                 2361585 
                 2361586 
                 2381158 
                 2381186 
                 13233 
                 13235 
                 YES 
                 O33258 
                 — 
               
               
                 2022 
                 2378768 
                 2378769 
                 2398368 
                 2398377 
                 13233 
                 13235 
                 YES 
                 O06237 
                 — 
               
               
                 2023 
                 2382325 
                 2382432 
                 2401925 
                 2401926 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2024 
                 2402489 
                 2402494 
                 2421973 
                 2421974 
                 13233 
                 13235 
                 YES 
                 O06217 
                 — 
               
               
                 2025 
                 2404055 
                 2404056 
                 2423535 
                 2423634 
                 13233 
                 13235 
                 YES 
                 O06215 
                 — 
               
               
                 2026 
                 2404228 
                 2404229 
                 2423816 
                 2423835 
                 13233 
                 13235 
                 YES 
                 O06215 
                 — 
               
               
                 2027 
                 2410508 
                 2410509 
                 2430114 
                 2431463 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2028 
                 2427464 
                 2427465 
                 2448428 
                 2448430 
                 13233 
                 13235 
                 YES 
                 O53521 
                 enzyme activity 
               
               
                 2029 
                 2440537 
                 2440642 
                 2461502 
                 2461503 
                 13233 
                 13235 
                 YES 
                 Q10389 
                 integral to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 membrane 
               
               
                 2030 
                 2480295 
                 2480297 
                 2501146 
                 2501147 
                 13233 
                 13235 
                 YES 
                 Q10511 
                 — 
               
               
                 2031 
                 2502267 
                 2502271 
                 2523205 
                 2523206 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2032 
                 2504789 
                 2504790 
                 2525724 
                 2525726 
                 13233 
                 13235 
                 YES 
                 O53525 
                 electron transport 
               
               
                 2033 
                 2511025 
                 2511026 
                 2531961 
                 2532058 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2034 
                 2513519 
                 2513520 
                 2534561 
                 2534564 
                 13233 
                 13235 
                 YES 
                 O53536 
                 nitrogen 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 metabolism 
               
               
                 2035 
                 2528967 
                 2528968 
                 2550011 
                 2551360 
                 13233 
                 13235 
                 YES 
                 Q50687 
                 glycerol 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 metabolism 
               
               
                 2036 
                 2540310 
                 2540311 
                 2562712 
                 2562714 
                 13233 
                 13235 
                 YES 
                 Q50675 
                 membrane 
               
               
                 2037 
                 2540853 
                 2540854 
                 2563256 
                 2563259 
                 13233 
                 13235 
                 YES 
                 Q59570 
                 thiosulfate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 sulfurtransferase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2038 
                 2541962 
                 2541964 
                 2564367 
                 2564368 
                 13233 
                 13235 
                 YES 
                 Q50673 
                 enzyme activity 
               
               
                 2039 
                 2544362 
                 2544364 
                 2566766 
                 2566767 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2040 
                 2584392 
                 2584410 
                 2606795 
                 2606796 
                 13233 
                 13235 
                 YES 
                 P71879 
                 transporter activity 
               
               
                 2041 
                 2592156 
                 2592158 
                 2614558 
                 2614559 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2042 
                 2607119 
                 2607120 
                 2639043 
                 2639047 
                 13233 
                 13235 
                 YES 
                 P95249 
                 — 
               
               
                 2043 
                 2658273 
                 2658275 
                 2690200 
                 2690201 
                 13233 
                 13235 
                 YES 
                 P71749 
                 — 
               
               
                 2044 
                 2661152 
                 2661153 
                 2693078 
                 2693088 
                 13233 
                 13235 
                 YES 
                 P71748 
                 oxygen transporter 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2045 
                 2672954 
                 2672976 
                 2704883 
                 2704884 
                 13233 
                 13235 
                 YES 
                 P71736 
                 — 
               
               
                 2046 
                 2673694 
                 2673779 
                 2705602 
                 2705603 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2047 
                 2679611 
                 2679613 
                 2711425 
                 2711426 
                 13233 
                 13235 
                 YES 
                 P71729 
                 — 
               
               
                 2048 
                 2689758 
                 2689759 
                 2721571 
                 2721574 
                 13233 
                 13235 
                 YES 
                 P71924 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2049 
                 2692384 
                 2692385 
                 2724199 
                 2724220 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2050 
                 2748934 
                 2748935 
                 2780769 
                 2780773 
                 13233 
                 13235 
                 YES 
                 O53203 
                 — 
               
               
                 2051 
                 2752776 
                 2752777 
                 2784614 
                 2785963 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2052 
                 2762072 
                 2762073 
                 2795268 
                 2795270 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2053 
                 2762938 
                 2762939 
                 2796135 
                 2796137 
                 13233 
                 13235 
                 YES 
                 O53212 
                 — 
               
               
                 2054 
                 2763778 
                 2763780 
                 2796976 
                 2796977 
                 13233 
                 13235 
                 YES 
                 O53212 
                 — 
               
               
                 2055 
                 2768766 
                 2768767 
                 2801963 
                 2801967 
                 13233 
                 13235 
                 YES 
                 O53215 
                 RNA-3′-phosphate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclase activity 
               
               
                 2056 
                 2769956 
                 2769957 
                 2803156 
                 2803166 
                 13233 
                 13235 
                 YES 
                 O53215 
                 RNA-3′-phosphate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclase activity 
               
               
                 2057 
                 2771738 
                 2771747 
                 2804947 
                 2804948 
                 13233 
                 13235 
                 YES 
                 O53215 
                 RNA-3′-phosphate 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclase activity 
               
               
                 2058 
                 2834003 
                 2834650 
                 2867204 
                 2867205 
                 13233 
                 13235 
                 YES 
                 P95009 
                 — 
               
               
                 2059 
                 2839452 
                 2839453 
                 2871997 
                 2871999 
                 13233 
                 13235 
                 YES 
                 P95001 
                 shikimate 5- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2060 
                 2849054 
                 2849055 
                 2881600 
                 2881602 
                 13233 
                 13235 
                 YES 
                 Q50737 
                 — 
               
               
                 2061 
                 2855417 
                 2855418 
                 2887964 
                 2887967 
                 13233 
                 13235 
                 YES 
                 Q50732 
                 — 
               
               
                 2062 
                 2863468 
                 2863469 
                 2896017 
                 2896019 
                 13233 
                 13235 
                 YES 
                 Q50649 
                 nucleic acid binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2063 
                 2890583 
                 2890593 
                 2923133 
                 2923134 
                 13233 
                 13235 
                 YES 
                 Q50630 
                 — 
               
               
                 2064 
                 2911188 
                 2911198 
                 2943729 
                 2943730 
                 13233 
                 13235 
                 YES 
                 O06199 
                 — 
               
               
                 2065 
                 2915441 
                 2915442 
                 2947973 
                 2947977 
                 13233 
                 13235 
                 YES 
                 O06191 
                 — 
               
               
                 2066 
                 2925032 
                 2925033 
                 2957567 
                 2957569 
                 13233 
                 13235 
                 YES 
                 P71930 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2067 
                 2925801 
                 2925803 
                 2958337 
                 2958338 
                 13233 
                 13235 
                 YES 
                 P71930 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2068 
                 2938901 
                 2938902 
                 2982418 
                 2982420 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2069 
                 2947177 
                 2947218 
                 2990695 
                 2990696 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2070 
                 2952702 
                 2952795 
                 2996165 
                 2996166 
                 13233 
                 13235 
                 YES 
                 O86317 
                 — 
               
               
                 2071 
                 3010580 
                 3010581 
                 3053941 
                 3053943 
                 13233 
                 13235 
                 YES 
                 O33284 
                 — 
               
               
                 2072 
                 3011358 
                 3011359 
                 3054720 
                 3054795 
                 13233 
                 13235 
                 YES 
                 O33284 
                 — 
               
               
                 2073 
                 3012343 
                 3012367 
                 3055789 
                 3055790 
                 13233 
                 13235 
                 YES 
                 O33285 
                 — 
               
               
                 2074 
                 3042938 
                 3042939 
                 3086361 
                 3086386 
                 13233 
                 13235 
                 YES 
                 O33321 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2075 
                 3043634 
                 3043635 
                 3087081 
                 3087083 
                 13233 
                 13235 
                 YES 
                 P30234 
                 alanine 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2076 
                 3064422 
                 3064426 
                 3107870 
                 3107871 
                 13233 
                 13235 
                 YES 
                 P71652 
                 — 
               
               
                 2077 
                 3073960 
                 3073961 
                 3117405 
                 3117408 
                 13233 
                 13235 
                 YES 
                 P71639 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2078 
                 3075770 
                 3075771 
                 3119217 
                 3119800 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2079 
                 3075914 
                 3076356 
                 3119953 
                 3119954 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2080 
                 3076439 
                 3076501 
                 3120027 
                 3120028 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2081 
                 3078601 
                 3078745 
                 3122118 
                 3122119 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2082 
                 3078967 
                 3078968 
                 3122331 
                 3122394 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2083 
                 3088034 
                 3088044 
                 3131469 
                 3131470 
                 13233 
                 13235 
                 YES 
                 P71629 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2084 
                 3098539 
                 3098540 
                 3141965 
                 3141967 
                 13233 
                 13235 
                 YES 
                 P71617 
                 transporter activity 
               
               
                 2085 
                 3112605 
                 3112606 
                 3156032 
                 3156073 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2086 
                 3146666 
                 3146667 
                 3190147 
                 3190149 
                 13233 
                 13235 
                 YES 
                 Q10806, Q10806 
                 — 
               
               
                 2087 
                 3150757 
                 3150759 
                 3194239 
                 3194240 
                 13233 
                 13235 
                 YES 
                 Q10809 
                 — 
               
               
                 2088 
                 3196190 
                 3196191 
                 3239559 
                 3239600 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2089 
                 3248018 
                 3248123 
                 3291442 
                 3291443 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2090 
                 3253069 
                 3253071 
                 3296379 
                 3296380 
                 13233 
                 13235 
                 YES 
                 P96284 
                 enzyme activity 
               
               
                 2091 
                 3267820 
                 3267822 
                 3311129 
                 3311130 
                 13233 
                 13235 
                 YES 
                 P95134 
                 metabolism 
               
               
                 2092 
                 3288055 
                 3288056 
                 3331363 
                 3331366 
                 13233 
                 13235 
                 YES 
                 P95120 
                 aspartic-type 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 endopeptidase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2093 
                 3293332 
                 3293333 
                 3336642 
                 3336751 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2094 
                 3294465 
                 3294466 
                 3337893 
                 3337903 
                 13233 
                 13235 
                 YES 
                 P95114 
                 cell wall 
               
               
                 2095 
                 3307774 
                 3307815 
                 3351211 
                 3351212 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2096 
                 3313357 
                 3313358 
                 3356738 
                 3356740 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2097 
                 3336999 
                 3337085 
                 3380437 
                 3380438 
                 13233 
                 13235 
                 YES 
                 O53268, O53268 
                 — 
               
               
                 2098 
                 3371757 
                 3371758 
                 3415194 
                 3415209 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2099 
                 3381643 
                 3381645 
                 3425094 
                 3425095 
                 13233 
                 13235 
                 YES 
                 P95097 
                 acyl-CoA 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2100 
                 3430544 
                 3430546 
                 3473994 
                 3473995 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2101 
                 3436512 
                 3436513 
                 3479961 
                 3479963 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2102 
                 3441287 
                 3441288 
                 3484737 
                 3487503 
                 13233 
                 13235 
                 YES 
                 O05793, O08362 
                 — 
               
               
                 2103 
                 3455437 
                 3456765 
                 3501662 
                 3501663 
                 13233 
                 13235 
                 YES 
                 P95191 
                 receptor activity 
               
               
                 2104 
                 3484092 
                 3484093 
                 3528980 
                 3528984 
                 13233 
                 13235 
                 YES 
                 O53309 
                 — 
               
               
                 2105 
                 3484287 
                 3486424 
                 3529178 
                 3529179 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2106 
                 3488662 
                 3488663 
                 3531407 
                 3531409 
                 13233 
                 13235 
                 YES 
                 O53312 
                 — 
               
               
                 2107 
                 3501951 
                 3501952 
                 3544697 
                 3544699 
                 13233 
                 13235 
                 YES 
                 O53326 
                 — 
               
               
                 2108 
                 3508479 
                 3508480 
                 3551226 
                 3552575 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2109 
                 3508604 
                 3508605 
                 3552709 
                 3554058 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2110 
                 3513313 
                 3513315 
                 3558776 
                 3558777 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2111 
                 3521477 
                 3521488 
                 3566939 
                 3566940 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2112 
                 3535183 
                 3535184 
                 3580635 
                 3580637 
                 13233 
                 13235 
                 YES 
                 O05863 
                 enzyme activity 
               
               
                 2113 
                 3537673 
                 3537674 
                 3583126 
                 3583130 
                 13233 
                 13235 
                 YES 
                 O05860 
                 enzyme activity 
               
               
                 2114 
                 3545179 
                 3545181 
                 3590635 
                 3590636 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2115 
                 3545228 
                 3545230 
                 3590683 
                 3590684 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2116 
                 3549001 
                 3549042 
                 3594455 
                 3594456 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2117 
                 3552793 
                 3552795 
                 3598191 
                 3598192 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2118 
                 3564990 
                 3564992 
                 3610387 
                 3610388 
                 13233 
                 13235 
                 YES 
                 O05879 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2119 
                 3600628 
                 3600629 
                 3646024 
                 3646037 
                 13233 
                 13235 
                 YES 
                 P96870 
                 transferase activity 
               
               
                 2120 
                 3618520 
                 3618521 
                 3663928 
                 3663982 
                 13233 
                 13235 
                 YES 
                 P96886 
                 — 
               
               
                 2121 
                 3662150 
                 3662151 
                 3707621 
                 3707625 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2122 
                 3681154 
                 3681156 
                 3723901 
                 3723902 
                 13233 
                 13235 
                 YES 
                 O53388 
                 — 
               
               
                 2123 
                 3692113 
                 3692114 
                 3738414 
                 3738416 
                 13233 
                 13235 
                 YES 
                 O53394, O53395 
                 — 
               
               
                 2124 
                 3692228 
                 3692247 
                 3738530 
                 3738531 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2125 
                 3692363 
                 3692364 
                 3738647 
                 3738758 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2126 
                 3694087 
                 3694165 
                 3740704 
                 3740705 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2127 
                 3694390 
                 3694391 
                 3740920 
                 3740930 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2128 
                 3694743 
                 3694812 
                 3741282 
                 3741283 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2129 
                 3695504 
                 3695505 
                 3741965 
                 3741967 
                 13233 
                 13235 
                 YES 
                 O53395 
                 — 
               
               
                 2130 
                 3700589 
                 3700590 
                 3747051 
                 3747053 
                 13233 
                 13235 
                 YES 
                 O50378 
                 — 
               
               
                 2131 
                 3706947 
                 3706948 
                 3753410 
                 3753680 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2132 
                 3708737 
                 3708738 
                 3755201 
                 3755207 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2133 
                 3713227 
                 3713228 
                 3759696 
                 3759698 
                 13233 
                 13235 
                 YES 
                 O50379 
                 — 
               
               
                 2134 
                 3733169 
                 3733265 
                 3779639 
                 3779640 
                 13233 
                 13235 
                 YES 
                 O50396 
                 — 
               
               
                 2135 
                 3733306 
                 3733316 
                 3779671 
                 3779672 
                 13233 
                 13235 
                 YES 
                 O50396 
                 — 
               
               
                 2136 
                 3744771 
                 3744772 
                 3791127 
                 3791132 
                 13233 
                 13235 
                 YES 
                 O50406 
                 enzyme activity 
               
               
                 2137 
                 3748507 
                 3748510 
                 3794864 
                 3794865 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2138 
                 3748698 
                 3748699 
                 3795053 
                 3796402 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2139 
                 3754439 
                 3754440 
                 3802152 
                 3802218 
                 13233 
                 13235 
                 YES 
                 O50415 
                 — 
               
               
                 2140 
                 3754539 
                 3754580 
                 3802327 
                 3802328 
                 13233 
                 13235 
                 YES 
                 O50415 
                 — 
               
               
                 2141 
                 3754972 
                 3754973 
                 3802700 
                 3802710 
                 13233 
                 13235 
                 YES 
                 O50415 
                 — 
               
               
                 2142 
                 3756095 
                 3756164 
                 3803832 
                 3803833 
                 13233 
                 13235 
                 YES 
                 O50415 
                 — 
               
               
                 2143 
                 3772838 
                 3773120 
                 3820497 
                 3820498 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2144 
                 3795208 
                 3795209 
                 3842576 
                 3847493 
                 13233 
                 13235 
                 YES 
                 Q50703, O06246 
                 — 
               
               
                 2145 
                 3810175 
                 3810176 
                 3862469 
                 3862471 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2146 
                 3822425 
                 3822426 
                 3874720 
                 3874722 
                 13233 
                 13235 
                 YES 
                 O06320 
                 — 
               
               
                 2147 
                 3826298 
                 3826299 
                 3878594 
                 3878598 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2148 
                 3826332 
                 3826333 
                 3878631 
                 3878633 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2149 
                 3843412 
                 3843413 
                 3897070 
                 3897774 
                 13233 
                 13235 
                 YES 
                 O06342 
                 enzyme activity 
               
               
                 2150 
                 3845388 
                 3845389 
                 3899759 
                 3899762 
                 13233 
                 13235 
                 YES 
                 O06343 
                 molecular_function 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 unknown 
               
               
                 2151 
                 3873325 
                 3873326 
                 3927698 
                 3927779 
                 13233 
                 13235 
                 YES 
                 O53552 
                 — 
               
               
                 2152 
                 3873813 
                 3873814 
                 3928276 
                 3928317 
                 13233 
                 13235 
                 YES 
                 O53552 
                 — 
               
               
                 2153 
                 3874278 
                 3874297 
                 3928795 
                 3928796 
                 13233 
                 13235 
                 YES 
                 O53552 
                 — 
               
               
                 2154 
                 3874602 
                 3874665 
                 3929101 
                 3929102 
                 13233 
                 13235 
                 YES 
                 O53552 
                 — 
               
               
                 2155 
                 3874830 
                 3874831 
                 3929257 
                 3929276 
                 13233 
                 13235 
                 YES 
                 O53552 
                 — 
               
               
                 2156 
                 3877295 
                 3877305 
                 3931731 
                 3931732 
                 13233 
                 13235 
                 YES 
                 O53553 
                 — 
               
               
                 2157 
                 3877742 
                 3877743 
                 3932169 
                 3932328 
                 13233 
                 13235 
                 YES 
                 O53553 
                 — 
               
               
                 2158 
                 3878312 
                 3878340 
                 3932781 
                 3932782 
                 13233 
                 13235 
                 YES 
                 O53553 
                 — 
               
               
                 2159 
                 3879828 
                 3879829 
                 3934873 
                 3934922 
                 13233 
                 13235 
                 YES 
                 O53553 
                 — 
               
               
                 2160 
                 3888742 
                 3888752 
                 3944049 
                 3944050 
                 13233 
                 13235 
                 YES 
                 O53557 
                 hydroxymethylglutaryl- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CoA reductase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (NADPH) activity 
               
               
                 2161 
                 3889054 
                 3889064 
                 3944352 
                 3944353 
                 13233 
                 13235 
                 YES 
                 O53557 
                 hydroxymethylglutaryl- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CoA reductase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (NADPH) activity 
               
               
                 2162 
                 3892768 
                 3892769 
                 3947748 
                 3948330 
                 13233 
                 13235 
                 YES 
                 O53559 
                 — 
               
               
                 2163 
                 3898149 
                 3898150 
                 3954929 
                 3954931 
                 13233 
                 13235 
                 YES 
                 O53563 
                 monooxygenase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2164 
                 3951089 
                 3951090 
                 4007870 
                 4007872 
                 13233 
                 13235 
                 YES 
                 P96848 
                 arylamine N- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2165 
                 3964661 
                 3964663 
                 4021443 
                 4021444 
                 13233 
                 13235 
                 YES 
                 P96861 
                 RNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2166 
                 3968799 
                 3968800 
                 4025580 
                 4025582 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2167 
                 3980409 
                 3980437 
                 4037191 
                 4037192 
                 13233 
                 13235 
                 YES 
                 O06287 
                 — 
               
               
                 2168 
                 3980524 
                 3980525 
                 4037279 
                 4037281 
                 13233 
                 13235 
                 YES 
                 O06287 
                 — 
               
               
                 2169 
                 3996679 
                 3996680 
                 4053435 
                 4053537 
                 13233 
                 13235 
                 YES 
                 O06272, O06271 
                 — 
               
               
                 2170 
                 3999617 
                 3999619 
                 4056484 
                 4056485 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2171 
                 4031594 
                 4031711 
                 4094354 
                 4094355 
                 13233 
                 13235 
                 YES 
                 O69621 
                 — 
               
               
                 2172 
                 4031993 
                 4031994 
                 4094627 
                 4094644 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2173 
                 4032348 
                 4032349 
                 4094998 
                 4095000 
                 13233 
                 13235 
                 YES 
                 O69623 
                 — 
               
               
                 2174 
                 4036755 
                 4036757 
                 4099406 
                 4099407 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2175 
                 4076537 
                 4076539 
                 4139187 
                 4139188 
                 13233 
                 13235 
                 YES 
                 O69664 
                 glycerol kinase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2176 
                 4092930 
                 4093092 
                 4155579 
                 4155580 
                 13233 
                 13235 
                 YES 
                 P96420 
                 enzyme activity 
               
               
                 2177 
                 4094427 
                 4094428 
                 4156905 
                 4156946 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2178 
                 4107128 
                 4107129 
                 4169665 
                 4169667 
                 13233 
                 13235 
                 YES 
                 O69691 
                 — 
               
               
                 2179 
                 4108423 
                 4108425 
                 4170961 
                 4170962 
                 13233 
                 13235 
                 YES 
                 O69692 
                 — 
               
               
                 2180 
                 4133434 
                 4133436 
                 4197137 
                 4197138 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2181 
                 4134910 
                 4134911 
                 4198612 
                 4198614 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2182 
                 4154969 
                 4154971 
                 4218672 
                 4218673 
                 13233 
                 13235 
                 YES 
                 P72040 
                 — 
               
               
                 2183 
                 4247018 
                 4247020 
                 4310742 
                 4310743 
                 13233 
                 13235 
                 YES 
                 P96242 
                 proteolysis and 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 peptidolysis 
               
               
                 2184 
                 4254698 
                 4254699 
                 4318421 
                 4318691 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2185 
                 4274868 
                 4274869 
                 4338592 
                 4338594 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2186 
                 4277269 
                 4277306 
                 4340994 
                 4340995 
                 13233 
                 13235 
                 YES 
                 P96213 
                 — 
               
               
                 2187 
                 4277709 
                 4277722 
                 4341398 
                 4341399 
                 13233 
                 13235 
                 YES 
                 P96213 
                 — 
               
               
                 2188 
                 4295484 
                 4295503 
                 4359161 
                 4359162 
                 13233 
                 13235 
                 YES 
                 O69743 
                 — 
               
               
                 2189 
                 4295520 
                 4295548 
                 4359179 
                 4359180 
                 13233 
                 13235 
                 YES 
                 O69743 
                 — 
               
               
                 2190 
                 4297431 
                 4297432 
                 4361063 
                 4361065 
                 13233 
                 13235 
                 YES 
                 Q933K8 
                 — 
               
               
                 2191 
                 4297455 
                 4297457 
                 4361088 
                 4361089 
                 13233 
                 13235 
                 YES 
                 Q933K8 
                 — 
               
               
                 2192 
                 4307387 
                 4307388 
                 4371019 
                 4373416 
                 13233 
                 13235 
                 YES 
                 O05457, O05455 
                 — 
               
               
                 2193 
                 4307808 
                 4307809 
                 4373846 
                 4373848 
                 13233 
                 13235 
                 YES 
                 O05454 
                 — 
               
               
                 2194 
                 4308332 
                 4308333 
                 4374371 
                 4374373 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2195 
                 4312098 
                 4312100 
                 4378138 
                 4378139 
                 13233 
                 13235 
                 YES 
                 O05450 
                 — 
               
               
                 2196 
                 4316061 
                 4316062 
                 4382100 
                 4382102 
                 13233 
                 13235 
                 YES 
                 O05448 
                 — 
               
               
                 2197 
                 4317102 
                 4317108 
                 4383142 
                 4383143 
                 13233 
                 13235 
                 YES 
                 O07036 
                 — 
               
               
                 2198 
                 4318998 
                 4318999 
                 4385033 
                 4385035 
                 13233 
                 13235 
                 YES 
                 O05446 
                 — 
               
               
                 2199 
                 4334624 
                 4334625 
                 4400660 
                 4400662 
                 13233 
                 13235 
                 YES 
                 O53590 
                 DNA binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2200 
                 3076218 
                 3076219 
                 3122987 
                 3123052 
                 13233 
                 13235 
                 YES 
                 Null 
                 — 
               
               
                 2201 
                 71576 
                 71614 
                 71584 
                 71585 
                 147805 
                 147807 
                 NO 
                 NULL 
                 NULL 
               
               
                 2202 
                 131213 
                 131215 
                 131174 
                 131175 
                 578886 
                 578887 
                 NO 
                 NULL 
                 NULL 
               
               
                 2203 
                 147853 
                 147854 
                 147812 
                 147814 
                 582109 
                 582110 
                 NO 
                 NULL 
                 NULL 
               
               
                 2204 
                 230770 
                 230772 
                 230575 
                 230576 
                 596768 
                 596769 
                 NO 
                 NULL 
                 NULL 
               
               
                 2205 
                 291957 
                 291959 
                 293631 
                 293632 
                 612279 
                 612281 
                 NO 
                 NULL 
                 NULL 
               
               
                 2206 
                 578459 
                 578500 
                 577494 
                 577495 
                 664896 
                 664897 
                 NO 
                 NULL 
                 NULL 
               
               
                 2207 
                 612063 
                 612064 
                 610910 
                 610912 
                 704228 
                 704229 
                 NO 
                 NULL 
                 NULL 
               
               
                 2208 
                 743870 
                 744394 
                 742632 
                 742633 
                 730004 
                 730005 
                 NO 
                 NULL 
                 NULL 
               
               
                 2209 
                 804268 
                 804309 
                 802498 
                 802499 
                 737681 
                 737682 
                 NO 
                 NULL 
                 NULL 
               
               
                 2210 
                 856450 
                 856451 
                 854258 
                 854260 
                 804527 
                 804680 
                 NO 
                 NULL 
                 NULL 
               
               
                 2211 
                 953566 
                 953567 
                 952809 
                 952811 
                 815060 
                 815062 
                 NO 
                 NULL 
                 NULL 
               
               
                 2212 
                 961024 
                 961025 
                 960268 
                 960309 
                 960120 
                 960270 
                 NO 
                 NULL 
                 NULL 
               
               
                 2213 
                 1064550 
                 1064551 
                 1064081 
                 1064110 
                 1090204 
                 1090205 
                 NO 
                 NULL 
                 NULL 
               
               
                 2214 
                 1090629 
                 1090631 
                 1090189 
                 1090190 
                 1172885 
                 1172887 
                 NO 
                 NULL 
                 NULL 
               
               
                 2215 
                 1165969 
                 1165971 
                 1165520 
                 1165521 
                 1277359 
                 1277361 
                 NO 
                 NULL 
                 NULL 
               
               
                 2216 
                 1173288 
                 1173289 
                 1172837 
                 1172839 
                 1305018 
                 1305133 
                 NO 
                 NULL 
                 NULL 
               
               
                 2217 
                 1306903 
                 1306904 
                 1305528 
                 1305643 
                 1312879 
                 1312880 
                 NO 
                 NULL 
                 NULL 
               
               
                 2218 
                 1314587 
                 1314589 
                 1313336 
                 1313337 
                 1365329 
                 1365330 
                 NO 
                 NULL 
                 NULL 
               
               
                 2219 
                 1475063 
                 1475064 
                 1477025 
                 1477027 
                 1408866 
                 1408867 
                 NO 
                 NULL 
                 NULL 
               
               
                 2220 
                 1539986 
                 1539987 
                 1541949 
                 1543298 
                 1476568 
                 1476570 
                 NO 
                 NULL 
                 NULL 
               
               
                 2221 
                 1837548 
                 1837549 
                 1852180 
                 1852182 
                 1489302 
                 1489303 
                 NO 
                 NULL 
                 NULL 
               
               
                 2222 
                 1892915 
                 1892916 
                 1907517 
                 1907558 
                 1606135 
                 1606137 
                 NO 
                 NULL 
                 NULL 
               
               
                 2223 
                 1914068 
                 1914069 
                 1928724 
                 1928726 
                 1630252 
                 1630253 
                 NO 
                 NULL 
                 NULL 
               
               
                 2224 
                 1941012 
                 1941053 
                 1955670 
                 1955671 
                 1644464 
                 1644505 
                 NO 
                 NULL 
                 NULL 
               
               
                 2225 
                 2064977 
                 2064978 
                 2074511 
                 2074614 
                 1843089 
                 1843091 
                 NO 
                 NULL 
                 NULL 
               
               
                 2226 
                 2087040 
                 2087041 
                 2096828 
                 2096830 
                 1886393 
                 1886394 
                 NO 
                 NULL 
                 NULL 
               
               
                 2227 
                 2093386 
                 2093387 
                 2103175 
                 2103177 
                 1898321 
                 1898362 
                 NO 
                 NULL 
                 NULL 
               
               
                 2228 
                 2099733 
                 2099735 
                 2109523 
                 2109524 
                 1919528 
                 1919530 
                 NO 
                 NULL 
                 NULL 
               
               
                 2229 
                 2199225 
                 2199227 
                 2207589 
                 2207590 
                 2094050 
                 2094052 
                 NO 
                 NULL 
                 NULL 
               
               
                 2230 
                 2254439 
                 2254440 
                 2270521 
                 2270531 
                 2100397 
                 2100399 
                 NO 
                 NULL 
                 NULL 
               
               
                 2231 
                 2347255 
                 2347256 
                 2365412 
                 2366761 
                 2132111 
                 2132112 
                 NO 
                 NULL 
                 NULL 
               
               
                 2232 
                 2349048 
                 2349049 
                 2368563 
                 2368565 
                 2484768 
                 2484769 
                 NO 
                 NULL 
                 NULL 
               
               
                 2233 
                 2382325 
                 2382432 
                 2401925 
                 2401926 
                 2484875 
                 2484876 
                 NO 
                 NULL 
                 NULL 
               
               
                 2234 
                 2410508 
                 2410509 
                 2430114 
                 2431463 
                 2529221 
                 2529262 
                 NO 
                 NULL 
                 NULL 
               
               
                 2235 
                 2502267 
                 2502271 
                 2523205 
                 2523206 
                 2562613 
                 2562614 
                 NO 
                 NULL 
                 NULL 
               
               
                 2236 
                 2511025 
                 2511026 
                 2531961 
                 2532058 
                 2701263 
                 2701264 
                 NO 
                 NULL 
                 NULL 
               
               
                 2237 
                 2544362 
                 2544364 
                 2566766 
                 2566767 
                 2721050 
                 2721071 
                 NO 
                 NULL 
                 NULL 
               
               
                 2238 
                 2592156 
                 2592158 
                 2614558 
                 2614559 
                 2790757 
                 2790759 
                 NO 
                 NULL 
                 NULL 
               
               
                 2239 
                 2673694 
                 2673779 
                 2705602 
                 2705603 
                 2846431 
                 2846432 
                 NO 
                 NULL 
                 NULL 
               
               
                 2240 
                 2692384 
                 2692385 
                 2724199 
                 2724220 
                 2953712 
                 2953714 
                 NO 
                 NULL 
                 NULL 
               
               
                 2241 
                 2752776 
                 2752777 
                 2784614 
                 2785963 
                 2977206 
                 2977208 
                 NO 
                 NULL 
                 NULL 
               
               
                 2242 
                 2762072 
                 2762073 
                 2795268 
                 2795270 
                 3088594 
                 3088595 
                 NO 
                 NULL 
                 NULL 
               
               
                 2243 
                 2938901 
                 2938902 
                 2982418 
                 2982420 
                 3113937 
                 3114520 
                 NO 
                 NULL 
                 NULL 
               
               
                 2244 
                 2947177 
                 2947218 
                 2990695 
                 2990696 
                 3114673 
                 3114674 
                 NO 
                 NULL 
                 NULL 
               
               
                 2245 
                 3075770 
                 3075771 
                 3119217 
                 3119800 
                 3116761 
                 3116762 
                 NO 
                 NULL 
                 NULL 
               
               
                 2246 
                 3075914 
                 3076356 
                 3119953 
                 3119954 
                 3117201 
                 3117264 
                 NO 
                 NULL 
                 NULL 
               
               
                 2247 
                 3076439 
                 3076501 
                 3120027 
                 3120028 
                 3150246 
                 3150287 
                 NO 
                 NULL 
                 NULL 
               
               
                 2248 
                 3078601 
                 3078745 
                 3122118 
                 3122119 
                 3220467 
                 3220468 
                 NO 
                 NULL 
                 NULL 
               
               
                 2249 
                 3078967 
                 3078968 
                 3122331 
                 3122394 
                 3233882 
                 3233923 
                 NO 
                 NULL 
                 NULL 
               
               
                 2250 
                 3112605 
                 3112606 
                 3156032 
                 3156073 
                 3285765 
                 3285766 
                 NO 
                 NULL 
                 NULL 
               
               
                 2251 
                 3196190 
                 3196191 
                 3239559 
                 3239600 
                 3330159 
                 3330160 
                 NO 
                 NULL 
                 NULL 
               
               
                 2252 
                 3248018 
                 3248123 
                 3291442 
                 3291443 
                 3345553 
                 3345554 
                 NO 
                 NULL 
                 NULL 
               
               
                 2253 
                 3293332 
                 3293333 
                 3336642 
                 3336751 
                 3370822 
                 3370824 
                 NO 
                 NULL 
                 NULL 
               
               
                 2254 
                 3307774 
                 3307815 
                 3351211 
                 3351212 
                 3475760 
                 3475762 
                 NO 
                 NULL 
                 NULL 
               
               
                 2255 
                 3313357 
                 3313358 
                 3356738 
                 3356740 
                 3561846 
                 3561847 
                 NO 
                 NULL 
                 NULL 
               
               
                 2256 
                 3371757 
                 3371758 
                 3415194 
                 3415209 
                 3585541 
                 3585542 
                 NO 
                 NULL 
                 NULL 
               
               
                 2257 
                 3430544 
                 3430546 
                 3473994 
                 3473995 
                 3589158 
                 3589159 
                 NO 
                 NULL 
                 NULL 
               
               
                 2258 
                 3436512 
                 3436513 
                 3479961 
                 3479963 
                 3589214 
                 3589215 
                 NO 
                 NULL 
                 NULL 
               
               
                 2259 
                 3484287 
                 3486424 
                 3529178 
                 3529179 
                 3589361 
                 3589363 
                 NO 
                 NULL 
                 NULL 
               
               
                 2260 
                 3508479 
                 3508480 
                 3551226 
                 3552575 
                 3590883 
                 3590885 
                 NO 
                 NULL 
                 NULL 
               
               
                 2261 
                 3508604 
                 3508605 
                 3552709 
                 3554058 
                 3590911 
                 3590912 
                 NO 
                 NULL 
                 NULL 
               
               
                 2262 
                 3513313 
                 3513315 
                 3558776 
                 3558777 
                 3685808 
                 3685849 
                 NO 
                 NULL 
                 NULL 
               
               
                 2263 
                 3521477 
                 3521488 
                 3566939 
                 3566940 
                 3702512 
                 3702516 
                 NO 
                 NULL 
                 NULL 
               
               
                 2264 
                 3545179 
                 3545181 
                 3590635 
                 3590636 
                 3717525 
                 3717526 
                 NO 
                 NULL 
                 NULL 
               
               
                 2265 
                 3545228 
                 3545230 
                 3590683 
                 3590684 
                 3747436 
                 3747442 
                 NO 
                 NULL 
                 NULL 
               
               
                 2266 
                 3549001 
                 3549042 
                 3594455 
                 3594456 
                 3787100 
                 3787101 
                 NO 
                 NULL 
                 NULL 
               
               
                 2267 
                 3662150 
                 3662151 
                 3707621 
                 3707625 
                 3811352 
                 3811353 
                 NO 
                 NULL 
                 NULL 
               
               
                 2268 
                 3706947 
                 3706948 
                 3753410 
                 3753680 
                 3835096 
                 3835097 
                 NO 
                 NULL 
                 NULL 
               
               
                 2269 
                 3708737 
                 3708738 
                 3755201 
                 3755207 
                 3864545 
                 3864549 
                 NO 
                 NULL 
                 NULL 
               
               
                 2270 
                 3748507 
                 3748510 
                 3794864 
                 3794865 
                 3864582 
                 3864584 
                 NO 
                 NULL 
                 NULL 
               
               
                 2271 
                 3748698 
                 3748699 
                 3795053 
                 3796402 
                 3903645 
                 3903646 
                 NO 
                 NULL 
                 NULL 
               
               
                 2272 
                 3772838 
                 3773120 
                 3820497 
                 3820498 
                 4017722 
                 4017724 
                 NO 
                 NULL 
                 NULL 
               
               
                 2273 
                 3810175 
                 3810176 
                 3862469 
                 3862471 
                 4086889 
                 4086906 
                 NO 
                 NULL 
                 NULL 
               
               
                 2274 
                 3826298 
                 3826299 
                 3878594 
                 3878598 
                 4091666 
                 4091667 
                 NO 
                 NULL 
                 NULL 
               
               
                 2275 
                 3826332 
                 3826333 
                 3878631 
                 3878633 
                 4109424 
                 4109425 
                 NO 
                 NULL 
                 NULL 
               
               
                 2276 
                 3968799 
                 3968800 
                 4025580 
                 4025582 
                 4160762 
                 4160763 
                 NO 
                 NULL 
                 NULL 
               
               
                 2277 
                 3999617 
                 3999619 
                 4056484 
                 4056485 
                 4348926 
                 4348927 
                 NO 
                 NULL 
                 NULL 
               
               
                 2278 
                 4031993 
                 4031994 
                 4094627 
                 4094644 
                 4366675 
                 4366677 
                 NO 
                 NULL 
                 NULL 
               
               
                 2279 
                 4036755 
                 4036757 
                 4099406 
                 4099407 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2280 
                 4094427 
                 4094428 
                 4156905 
                 4156946 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2281 
                 4133434 
                 4133436 
                 4197137 
                 4197138 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2282 
                 4134910 
                 4134911 
                 4198612 
                 4198614 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2283 
                 4254698 
                 4254699 
                 4318421 
                 4318691 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2284 
                 4274868 
                 4274869 
                 4338592 
                 4338594 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2285 
                 4308332 
                 4308333 
                 4374371 
                 4374373 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                 2286 
                 3076218 
                 3076219 
                 3122987 
                 3123052 
                   
                   
                 NO 
                 NULL 
                 NULL 
               
               
                   
               
               
                   Table II: List of insertion/deletions (indels) in  Mycobacaterium tuberculosis / M. bovis  BCG    
               
               
                   Polymorphism ID: The ID by which the polymorphism can be identified    
               
               
                   BCG Start: The position in the genome of  M. bovis  BCG at which insertion/deletion starts    
               
               
                   BCG End: The position in the genome of  M. bovis  BCG at which insertion/deletion ends    
               
               
                   H37Rv Start: The position in the genome of  M. tuberculosis  H37Rv at which insertion/deletion starts    
               
               
                   H37Rv End: The position in the genome of  M. tuberculosis  H37Rv at which insertion/deletion ends    
               
               
                   CDC1551 Start: The position in the genome of  M. tuberculosis  CDC1551 at which insertion/deletion starts    
               
               
                   CDC1551 End: The position in the genome of  M. tuberculosis  CDC1551 at which insertion/deletion ends    
               
               
                   ORF: Indicates whether the polymorphism occurs in an open reading frame (yes) or not (no)    
               
               
                   GO ID: The ID for the sequence in the gene ontology database    
               
               
                   Putative function: The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0245]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                   
               
               
                 List of long polymorphisms in  Mycobacterium tuberculosis / M. bovis  BCG. 
               
             
          
           
               
                 Polymorphism 
                 BCG 
                   
                 H37Rv 
                 H37Rv 
                   
                   
                   
                   
                   
               
               
                 ID 
                 Start 
                 BCG End 
                 start 
                 end 
                 CDC start 
                 CDC end 
                 ORF 
                 GO ID 
                 Putative Function 
               
               
                   
               
             
          
           
               
                 2287 
                 55529 
                 55544 
                 55543 
                 55552 
                 103765 
                 105054 
                 Yes 
                 P71707 
                 enzyme activity 
               
               
                 2288 
                 103810 
                 105100 
                 103773 
                 105062 
                 103765 
                 105054 
                 Yes 
                 Q50655, 
                 — 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Q10891 
               
               
                 2289 
                 337700 
                 337733 
                 336678 
                 336711 
                 103765 
                 105054 
                 Yes 
                 O53684 
                 — 
               
               
                 2290 
                 339670 
                 339722 
                 338666 
                 338718 
                 103765 
                 105054 
                 Yes 
                 O53684 
                 — 
               
               
                 2291 
                 468517 
                 468610 
                 467498 
                 467589 
                 103765 
                 105054 
                 Yes 
                 O53722 
                 — 
               
               
                 2292 
                 840823 
                 840895 
                 838955 
                 838967 
                 103765 
                 105054 
                 Yes 
                 O53810 
                 — 
               
               
                 2293 
                 891209 
                 892235 
                 889018 
                 891403 
                 103765 
                 105054 
                 Yes 
                 O07182 
                 DNA binding activity 
               
               
                 2294 
                 928362 
                 928365 
                 927446 
                 927461 
                 103765 
                 105054 
                 Yes 
                 O53844 
                 — 
               
               
                 2295 
                 1094366 
                 1094867 
                 1093925 
                 1094414 
                 103765 
                 105054 
                 Yes 
                 O53891 
                 — 
               
               
                 2296 
                 1413023 
                 1413095 
                 1414785 
                 1414947 
                 103765 
                 105054 
                 Yes 
                 Q11053 
                 protein kinase activity 
               
               
                 2297 
                 1466961 
                 1466963 
                 1468912 
                 1468925 
                 103765 
                 105054 
                 Yes 
                 Q10621 
                 DNA binding activity 
               
               
                 2298 
                 1530977 
                 1531052 
                 1532940 
                 1533015 
                 103765 
                 105054 
                 Yes 
                 Q11031 
                 — 
               
               
                 2299 
                 1531093 
                 1531199 
                 1533056 
                 1533162 
                 103765 
                 105054 
                 Yes 
                 Q11031 
                 — 
               
               
                 2300 
                 1619416 
                 1619437 
                 1623086 
                 1623088 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2301 
                 1629885 
                 1631221 
                 1633536 
                 1634635 
                 103765 
                 105054 
                 Yes 
                 O06810 
                 — 
               
               
                 2302 
                 1633501 
                 1634095 
                 1636765 
                 1637347 
                 103765 
                 105054 
                 Yes 
                 O06808 
                 — 
               
               
                 2303 
                 1634927 
                 1634959 
                 1638179 
                 1638211 
                 103765 
                 105054 
                 Yes 
                 O06808 
                 — 
               
               
                 2304 
                 1773935 
                 1775045 
                 1788567 
                 1789677 
                 103765 
                 105054 
                 Yes 
                 O06603, 
                 — 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 O06602 
               
               
                 2305 
                 1986939 
                 1988741 
                 1996098 
                 1998299 
                 103765 
                 105054 
                 Yes 
                 O06798 
                 nucleic acid binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2306 
                 2156908 
                 2157537 
                 2165848 
                 2165901 
                 103765 
                 105054 
                 Yes 
                 O07716 
                 enzyme activity 
               
               
                 2307 
                 2241088 
                 2241814 
                 2262170 
                 2262896 
                 103765 
                 105054 
                 Yes 
                 O53461 
                 nucleic acid binding 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2308 
                 2278758 
                 2278826 
                 2294843 
                 2294911 
                 103765 
                 105054 
                 Yes 
                 O53490 
                 enzyme activity 
               
               
                 2309 
                 2278938 
                 2278961 
                 2295023 
                 2295046 
                 103765 
                 105054 
                 Yes 
                 O53490 
                 enzyme activity 
               
               
                 2310 
                 2279216 
                 2280345 
                 2295301 
                 2296430 
                 103765 
                 105054 
                 Yes 
                 O53490 
                 enzyme activity 
               
               
                 2311 
                 2285306 
                 2286046 
                 2301391 
                 2302131 
                 103765 
                 105054 
                 Yes 
                 O53490 
                 enzyme activity 
               
               
                 2312 
                 2501326 
                 2501345 
                 2522176 
                 2522283 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2313 
                 2604210 
                 2605004 
                 2635574 
                 2636928 
                 103765 
                 105054 
                 Yes 
                 P95248 
                 — 
               
               
                 2314 
                 2912021 
                 2912672 
                 2944553 
                 2945204 
                 103765 
                 105054 
                 Yes 
                 O06199 
                 — 
               
               
                 2315 
                 3079181 
                 3079369 
                 3122617 
                 3123099 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2316 
                 3079550 
                 3079876 
                 3123280 
                 3123311 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2317 
                 3189218 
                 3189388 
                 3232699 
                 3232757 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2318 
                 3204423 
                 3204457 
                 3247847 
                 3247881 
                 103765 
                 105054 
                 Yes 
                 Q10977 
                 enzyme activity 
               
               
                 2319 
                 3334709 
                 3334850 
                 3378091 
                 3378288 
                 103765 
                 105054 
                 Yes 
                 P31500 
                 — 
               
               
                 2320 
                 3336266 
                 3336348 
                 3379704 
                 3379786 
                 103765 
                 105054 
                 Yes 
                 O53268 
                 — 
               
               
                 2321 
                 3689443 
                 3689509 
                 3732189 
                 3735810 
                 103765 
                 105054 
                 Yes 
                 O53393 
                 carboxypeptidase A 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2322 
                 3689905 
                 3689925 
                 3736206 
                 3736226 
                 103765 
                 105054 
                 Yes 
                 O53393 
                 carboxypeptidase A 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2323 
                 3692719 
                 3692740 
                 3739123 
                 3739357 
                 103765 
                 105054 
                 Yes 
                 O53395 
                 — 
               
               
                 2324 
                 3703709 
                 3703744 
                 3750172 
                 3750207 
                 103765 
                 105054 
                 Yes 
                 O50378 
                 — 
               
               
                 2325 
                 3838472 
                 3838474 
                 3890772 
                 3892132 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2326 
                 3876017 
                 3876037 
                 3930462 
                 3930473 
                 103765 
                 105054 
                 Yes 
                 O53552 
                 — 
               
               
                 2327 
                 3878151 
                 3878280 
                 3932746 
                 3932749 
                 103765 
                 105054 
                 Yes 
                 O53553 
                 — 
               
               
                 2328 
                 3879035 
                 3879494 
                 3933477 
                 3934539 
                 103765 
                 105054 
                 Yes 
                 O53553 
                 — 
               
               
                 2329 
                 3879583 
                 3879686 
                 3934628 
                 3934731 
                 103765 
                 105054 
                 Yes 
                 O53553 
                 — 
               
               
                 2330 
                 3879863 
                 3880576 
                 3934956 
                 3936335 
                 103765 
                 105054 
                 Yes 
                 O53553 
                 — 
               
               
                 2331 
                 3885770 
                 3886315 
                 3941529 
                 3941721 
                 103765 
                 105054 
                 Yes 
                 O53556, 
                 — 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 O53557 
               
               
                 2332 
                 3887733 
                 3887868 
                 3943139 
                 3943175 
                 103765 
                 105054 
                 Yes 
                 O53557 
                 hydroxymethylglutaryl- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CoA reductase (NADPH) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 2333 
                 3890973 
                 3891602 
                 3946262 
                 3946876 
                 103765 
                 105054 
                 Yes 
                 O53559 
                 — 
               
               
                 2334 
                 3891837 
                 3892400 
                 3947111 
                 3947380 
                 103765 
                 105054 
                 Yes 
                 O53559 
                 — 
               
               
                 2335 
                 3892771 
                 3892967 
                 3948342 
                 3949747 
                 103765 
                 105054 
                 Yes 
                 O53559 
                 — 
               
               
                 2336 
                 4127053 
                 4127055 
                 4189590 
                 4190758 
                 103765 
                 105054 
                 Yes 
                 O69705 
                 — 
               
               
                 2337 
                 4189866 
                 4189868 
                 4253568 
                 4253581 
                 103765 
                 105054 
                 Yes 
                 Q10621 
                 DNA binding activity 
               
               
                 2338 
                 4190616 
                 4190621 
                 4254329 
                 4254345 
                 103765 
                 105054 
                 Yes 
                 Null 
                 — 
               
               
                 2339 
                 1973115 
                 1973588 
                 2628042 
                 2630136 
                 103765 
                 105054 
                 Yes 
                 P95245, 
                 — 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 P95246 
                 — 
               
               
                 2340 
                 3079605 
                 3079661 
                 3119272 
                 3119329 
                 103765 
                 105054 
                 Yes 
                 Null 
                 Null 
               
               
                 2341 
                 1619416 
                 1619437 
                 1623086 
                 1623088 
                 1622970 
                 1622972 
                 No 
                 Null 
                 Null 
               
               
                 2342 
                 2501326 
                 2501345 
                 2522176 
                 2522283 
                 2354339 
                 2354347 
                 No 
                 Null 
                 Null 
               
               
                 2343 
                 3079181 
                 3079369 
                 3122617 
                 3123099 
                 2519450 
                 2519556 
                 No 
                 Null 
                 Null 
               
               
                 2344 
                 3079550 
                 3079876 
                 3123280 
                 3123311 
                 2520462 
                 2520465 
                 No 
                 Null 
                 Null 
               
               
                 2345 
                 3189218 
                 3189388 
                 3232699 
                 3232757 
                 2985403 
                 2985518 
                 No 
                 Null 
                 Null 
               
               
                 2346 
                 3838472 
                 3838474 
                 3890772 
                 3892132 
                 3018402 
                 3018431 
                 No 
                 Null 
                 Null 
               
               
                 2347 
                 4190616 
                 4190621 
                 4254329 
                 4254345 
                 3226853 
                 3226952 
                 No 
                 Null 
                 Null 
               
               
                 2348 
                 3079605 
                 3079661 
                 3119272 
                 3119329 
                 3589269 
                 3589323 
                 No 
                 Null 
                 Null 
               
               
                 2349 
                   
                   
                   
                   
                 4245189 
                 4245204 
                 No 
                 Null 
                 Null 
               
               
                 2350 
                   
                   
                   
                   
                 4246654 
                 4246670 
                 No 
                 Null 
                 Null 
               
               
                 2351 
                   
                   
                   
                   
                 3113992 
                 3114049 
                 No 
                 Null 
                 Null 
               
               
                   
               
               
                   Table III: List of long polymorphisms in  Mycobacaterium tuberculosis / M. bovis  BCG    
               
               
                   Polymorphism ID: The ID by which the polymorphism can be identified    
               
               
                   BCG Start: The position in the genome of  M. bovis  BCG at which multiple polymorhisms start occurring    
               
               
                   BCG End: The position in the genome of  M. bovis  BCG at which multiple polymorhisms end    
               
               
                   H37Rv Start: The position in the genome of  M. tuberculosis  H37Rv at which multiple polymorhisms start    
               
               
                   H37Rv End: The position in the genome of  M. tuberculosis  H37Rv at multiple polymorhisms end    
               
               
                   C1551 Start: The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms start    
               
               
                   CDC1551 End: The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms ends    
               
               
                   ORF: Indicates whether the polymorphism occurs in an open reading frame (yes) or not (no)    
               
               
                   GO ID: The ID for the sequence in the gene ontology database    
               
               
                   Putative function: The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0246]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                   
               
             
             
               
                 a: 
               
               
                 List of Polymorphisms (Single Nucleotide Polymorphisms) in genes involved in cell wall synthesis 
               
             
          
           
               
                 Polymorphism 
                   
                 BCG 
                   
                 Query 
                 Query 
                 Query 
                 Query 
                   
                 Type of 
                   
                 Putative 
               
               
                 ID 
                 BCG Position 
                 base 
                 BCG AA 
                 name 
                 Position 
                 base 
                 aa 
                 ORF 
                 SNP 
                 GO ID 
                 Function 
               
               
                   
               
               
                  48 
                 53663 
                 T 
                 L 
                 H37Rv 
                 53677 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 P71707 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                  48 
                 53663 
                 T 
                 L 
                 CDC1551 
                 53623 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 Q8VKS5 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1014 
                 2393645 
                 G 
                 P 
                 H37Rv 
                 2413129 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 O06224 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1014 
                 2393645 
                 G 
                 P 
                 CDC1551 
                 2411822 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 O06224 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1015 
                 2393760 
                 A 
                 L 
                 H37Rv 
                 2413244 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O06224 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1015 
                 2393760 
                 A 
                 L 
                 CDC1551 
                 2411937 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O06224 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1240 
                 2987804 
                 G 
                 H 
                 H37Rv 
                 3031165 
                 A 
                 Y 
                 Yes 
                 NS, C 
                 O07218 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1240 
                 2987804 
                 G 
                 H 
                 CDC1551 
                 3026104 
                 A 
                 Y 
                 Yes 
                 NS, C 
                 O07218 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1746 
                 4176966 
                 T 
                 I 
                 H37Rv 
                 4240668 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 P72059 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1746 
                 4176966 
                 T 
                 I 
                 CDC1551 
                 4232983 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 P72059 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1749 
                 4182846 
                 G 
                 S 
                 H37Rv 
                 4246548 
                 A 
                 N 
                 Yes 
                 NS, C 
                 P72030 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1749 
                 4182846 
                 G 
                 S 
                 CDC1551 
                 4238863 
                 A 
                 N 
                 Yes 
                 NS, C 
                 P72030 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1751 
                 4183941 
                 C 
                 A 
                 H37Rv 
                 4247643 
                 A 
                 E 
                 Yes 
                 NS, NC 
                 P72030 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                 1751 
                 4183941 
                 C 
                 A 
                 CDC1551 
                 4239958 
                 A 
                 E 
                 Yes 
                 NS, NC 
                 P72030 
                 Cell wall 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 synthesis 
               
               
                   
               
             
          
           
               
                 Polymorphism 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 ID 
                 BCG start 
                 BCG end 
                 Query name 
                 Query start 
                 Query end 
                 ORF 
                 GO ID 
                 Putative Function 
               
               
                   
               
             
          
           
               
                 b: 
               
               
                 List of Polymorphisms (Insertions/deletions) in genes involved in cell wall synthesis 
               
             
          
           
               
                 1906 
                 936197 
                 936204 
                 H37Rv 
                 935446 
                 935447 
                 Yes 
                 O53850 
                 Cell wall synthesis 
               
               
                 1947 
                 1439690 
                 1439691 
                 H37Rv 
                 1441542 
                 1441686 
                 Yes 
                 Q10614 
                 Cell wall synthesis 
               
               
                 2094 
                 3294465 
                 3294466 
                 H37Rv 
                 3337893 
                 3337903 
                 Yes 
                 P95114 
                 Cell wall synthesis 
               
               
                 1906 
                 936197 
                 936204 
                 CDC1551 
                 935348 
                 935349 
                 Yes 
                 O53850 
                 Cell wall synthesis 
               
               
                 1947 
                 1439690 
                 1439691 
                 CDC1551 
                 1441030 
                 1441174 
                 Yes 
                 Q10614 
                 Cell wall synthesis 
               
               
                 2094 
                 3294465 
                 3294466 
                 CDC1551 
                 3332273 
                 3332283 
                 Yes 
                 P95114 
                 Cell wall synthesis 
               
             
          
           
               
                 c: 
               
               
                 List of Polymorphisms (long polymorphisms) in genes involved in cell wall synthesis 
               
             
          
           
               
                 2287 
                 55529 
                 55544 
                 H37Rv 
                 55543 
                 55552 
                 Yes 
                 P71707 
                 Cell wall Synthesis 
               
               
                   
               
               
                   Table IV: List of long polymorphisms in genes involved in cell wall synthesis    
               
               
                   Polymorphism ID: The ID by which the polymorphism can be identified    
               
               
                   BCG Start: The position in the genome of  M. bovis  BCG at which multiple polymorhisms start occurring    
               
               
                   BCG End: The position in the genome of  M. bovis  BCG at which multiple polymorhisms end    
               
               
                   H37Rv Start: The position in the genome of  M. tuberculosis  H37Rv at which multiple polymorhisms start    
               
               
                   H37Rv End: The position in the genome of  M. tuberculosis  H37Rv at multiple polymorhisms end    
               
               
                   C1551 Start: The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms start    
               
               
                   CDC1551 End: The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms ends    
               
               
                   ORF: Indicates whether the polymorphism occurs in an open reading frame (yes) or not (no)    
               
               
                   GO ID: The ID for the sequence in the gene ontology database    
               
               
                   Putative function: The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0247]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 5 
               
               
                   
               
               
                   
               
             
             
               
                 a: List of Polymorphisms (Single Nucleotide Polymorphisms) in transcription factors. 
               
             
          
           
               
                 Polymorphism 
                 BCG 
                 BCG 
                 BCG 
                 Query 
                 Query 
                 Query 
                 Query 
                   
                 Type of 
                   
                   
               
               
                 ID 
                 Position 
                 base 
                 AA 
                 name 
                 Position 
                 base 
                 aa 
                 ORF 
                 SNP 
                 GO ID 
                 Putative Function 
               
               
                   
               
               
                  63 
                 86899 
                 G 
                 V 
                 H37Rv 
                 86862 
                 A 
                 I 
                 Yes 
                 NS, C 
                 O53623 
                 Transcription factor 
               
               
                  63 
                 86899 
                 G 
                 V 
                 CDC1551 
                 86854 
                 A 
                 I 
                 Yes 
                 NS, C 
                 O53623 
                 Transcription factor 
               
               
                 188 
                 366022 
                 T 
                 V 
                 H37Rv 
                 364973 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O07229 
                 Transcription factor 
               
               
                 188 
                 366022 
                 T 
                 V 
                 CDC1551 
                 365037 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O07229 
                 Transcription factor 
               
               
                 228 
                 456342 
                 G 
                 R 
                 H37Rv 
                 455323 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 O53712 
                 Transcription factor 
               
               
                 228 
                 456342 
                 G 
                 R 
                 CDC1551 
                 455414 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 O53712 
                 Transcription factor 
               
               
                 231 
                 467402 
                 C 
                 A 
                 H37Rv 
                 466383 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O53720 
                 Transcription factor 
               
               
                 231 
                 467402 
                 C 
                 A 
                 CDC1551 
                 466474 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O53720 
                 Transcription factor 
               
               
                 299 
                 634973 
                 C 
                 V 
                 CDC1551 
                 635181 
                 T 
                 I 
                 Yes 
                 NS, C 
                 Q8VKJ4 
                 Transcription factor 
               
               
                 313 
                 671788 
                 A 
                 H 
                 H37Rv 
                 670543 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O53773 
                 Transcription factor 
               
               
                 313 
                 671788 
                 A 
                 H 
                 CDC1551 
                 671996 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O53773 
                 Transcription factor 
               
               
                 326 
                 700963 
                 T 
                 I 
                 H37Rv 
                 699716 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O07776 
                 Transcription factor 
               
               
                 326 
                 700963 
                 T 
                 I 
                 CDC1551 
                 701166 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O07776 
                 Transcription factor 
               
               
                 405 
                 912091 
                 C 
                 P 
                 H37Rv 
                 911259 
                 T 
                 L 
                 Yes 
                 NS, NC 
                 O53830 
                 Transcription factor 
               
               
                 405 
                 912091 
                 C 
                 P 
                 CDC1551 
                 911170 
                 T 
                 L 
                 Yes 
                 NS, NC 
                 O53830 
                 Transcription factor 
               
               
                 433 
                 941645 
                 G 
                 P 
                 H37Rv 
                 940888 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 O53856 
                 Transcription factor 
               
               
                 433 
                 941645 
                 G 
                 P 
                 CDC1551 
                 940790 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 O53856 
                 Transcription factor 
               
               
                 483 
                 1097474 
                 A 
                 S 
                 H37Rv 
                 1097021 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O53894 
                 Transcription factor 
               
               
                 483 
                 1097474 
                 A 
                 S 
                 CDC1551 
                 1097062 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O53894 
                 Transcription factor 
               
               
                 598 
                 1375153 
                 G 
                 P 
                 H37Rv 
                 1373907 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 O86313 
                 Transcription factor 
               
               
                 598 
                 1375153 
                 G 
                 P 
                 CDC1551 
                 1373397 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 O86313 
                 Transcription factor 
               
               
                 611 
                 1401640 
                 G 
                 V 
                 H37Rv 
                 1400394 
                 A 
                 M 
                 Yes 
                 NS, NC 
                 Q11039 
                 Transcription factor 
               
               
                 611 
                 1401640 
                 G 
                 V 
                 CDC1551 
                 1399883 
                 A 
                 M 
                 Yes 
                 NS, NC 
                 Q11039 
                 Transcription factor 
               
               
                 639 
                 1476918 
                 T 
                 * 
                 H37Rv 
                 1478881 
                 C 
                 W 
                 Yes 
                 NS, TP 
                 Q10630 
                 Transcription factor 
               
               
                 639 
                 1476918 
                 T 
                 * 
                 CDC1551 
                 1478424 
                 C 
                 W 
                 Yes 
                 NS, TP 
                 Q10630 
                 Transcription factor 
               
               
                 640 
                 1477120 
                 C 
                 V 
                 H37Rv 
                 1479083 
                 T 
                 I 
                 Yes 
                 NS, C 
                 Q10630 
                 Transcription factor 
               
               
                 640 
                 1477120 
                 C 
                 V 
                 CDC1551 
                 1478626 
                 T 
                 I 
                 Yes 
                 NS, C 
                 Q10630 
                 Transcription factor 
               
               
                 659 
                 1524738 
                 T 
                 V 
                 H37Rv 
                 1526701 
                 G 
                 G 
                 Yes 
                 NS, C 
                 Q11028 
                 Transcription factor 
               
               
                 659 
                 1524738 
                 T 
                 V 
                 CDC1551 
                 1527918 
                 G 
                 G 
                 Yes 
                 NS, C 
                 Q8VK33 
                 Transcription factor 
               
               
                 660 
                 1525971 
                 C 
                 A 
                 H37Rv 
                 1527934 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 Q11028 
                 Transcription factor 
               
               
                 660 
                 1525971 
                 C 
                 A 
                 CDC1551 
                 1529151 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 Q8VK33 
                 Transcription factor 
               
               
                 677 
                 1534974 
                 T 
                 T 
                 H37Rv 
                 1536937 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q11034 
                 Transcription factor 
               
               
                 677 
                 1534974 
                 T 
                 T 
                 CDC1551 
                 1538155 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q11034 
                 Transcription factor 
               
               
                 700 
                 1580686 
                 C 
                 L 
                 H37Rv 
                 1584377 
                 A 
                 I 
                 Yes 
                 NS, C 
                 P71675 
                 Transcription factor 
               
               
                 700 
                 1580686 
                 C 
                 L 
                 CDC1551 
                 1584233 
                 A 
                 I 
                 Yes 
                 NS, C 
                 P71675 
                 Transcription factor 
               
               
                 722 
                 1643728 
                 T 
                 V 
                 H37Rv 
                 1646980 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O53151 
                 Transcription factor 
               
               
                 722 
                 1643728 
                 T 
                 V 
                 CDC1551 
                 1647138 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O53151 
                 Transcription factor 
               
               
                 801 
                 1886196 
                 G 
                 A 
                 H37Rv 
                 1900798 
                 A 
                 V 
                 Yes 
                 NS, C 
                 O53922 
                 Transcription factor 
               
               
                 801 
                 1886196 
                 G 
                 A 
                 CDC1551 
                 1891602 
                 A 
                 V 
                 Yes 
                 NS, C 
                 O53922 
                 Transcription factor 
               
               
                 1061  
                 2504215 
                 G 
                 A 
                 H37Rv 
                 2525150 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 Q10528 
                 Transcription factor 
               
               
                 1061  
                 2504215 
                 G 
                 A 
                 CDC1551 
                 2522412 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 Q10528 
                 Transcription factor 
               
               
                 1099  
                 2609911 
                 G 
                 R 
                 H37Rv 
                 2641838 
                 A 
                 H 
                 Yes 
                 NS, NC 
                 O05839 
                 Transcription factor 
               
               
                 1099  
                 2609911 
                 G 
                 R 
                 CDC1551 
                 2639170 
                 A 
                 H 
                 Yes 
                 NS, NC 
                 O05839 
                 Transcription factor 
               
               
                 1174  
                 2825466 
                 T 
                 D 
                 H37Rv 
                 2858667 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P95020 
                 Transcription factor 
               
               
                 1174  
                 2825466 
                 T 
                 D 
                 CDC1551 
                 2854156 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P95020 
                 Transcription factor 
               
               
                 1241  
                 2988773 
                 C 
                 A 
                 H37Rv 
                 3032134 
                 T 
                 V 
                 Yes 
                 NS, C 
                 Q50765 
                 Transcription factor 
               
               
                 1241  
                 2988773 
                 C 
                 A 
                 CDC1551 
                 3027073 
                 T 
                 V 
                 Yes 
                 NS, C 
                 Q50765 
                 Transcription factor 
               
               
                 1261  
                 3043278 
                 T 
                 I 
                 H37Rv 
                 3086725 
                 C 
                 M 
                 Yes 
                 NS, NC 
                 O33321 
                 Transcription factor 
               
               
                 1261  
                 3043278 
                 T 
                 I 
                 CDC1551 
                 3081450 
                 C 
                 M 
                 Yes 
                 NS, NC 
                 O33321 
                 Transcription factor 
               
               
                 1264  
                 3053917 
                 C 
                 A 
                 H37Rv 
                 3097365 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O33330 
                 Transcription factor 
               
               
                 1264  
                 3053917 
                 C 
                 A 
                 CDC1551 
                 3092089 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O33330 
                 Transcription factor 
               
               
                 1405  
                 3404010 
                 A 
                 C 
                 H37Rv 
                 3447460 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 Q06861 
                 Transcription factor 
               
               
                 1405  
                 3404010 
                 A 
                 C 
                 CDC1551 
                 3443253 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 Q06861 
                 Transcription factor 
               
               
                 1503  
                 3626758 
                 A 
                 V 
                 H37Rv 
                 3672229 
                 G 
                 A 
                 Yes 
                 NS, C 
                 P96896 
                 Transcription factor 
               
               
                 1503  
                 3626758 
                 A 
                 V 
                 CDC1551 
                 3667068 
                 G 
                 A 
                 Yes 
                 NS, C 
                 P96896 
                 Transcription factor 
               
               
                   
               
             
          
           
               
                 b: List of Polymorphisms (Insertions/Deletions) in transcription factors. 
               
             
          
           
               
                 Polymorphism 
                   
                   
                   
                   
                   
                   
                 Functional 
                 Putative 
               
               
                 ID 
                 BCG start 
                 BCG end 
                 Query name 
                 Query start 
                 Query end 
                 ORF 
                 Annotation 
                 Function 
               
               
                   
               
               
                 1849 
                 194495 
                 194498 
                 H37Rv 
                 194303 
                 194304 
                 Yes 
                 O07410 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                 2074 
                 3042938 
                 3042939 
                 H37Rv 
                 3086361 
                 3086386 
                 Yes 
                 O33321 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                 2199 
                 4334624 
                 4334625 
                 H37Rv 
                 4400660 
                 4400662 
                 Yes 
                 O53590 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                 1902 
                 890037 
                 890038 
                 CDC1551 
                 889115 
                 889117 
                 Yes 
                 Q8VKD9 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                 1945 
                 1404177 
                 1404178 
                 CDC1551 
                 1402420 
                 1405418 
                 Yes 
                 Q11063 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                 2074 
                 3042938 
                 3042939 
                 CDC1551 
                 3081086 
                 3081111 
                 Yes 
                 O33321 
                 Transcription 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Factor 
               
               
                   
               
               
                   Table V: List of long polymorphisms in Transcription factors    
               
               
                   Polymorphism ID The ID by which the polymorphism can be identified    
               
               
                   BCG Start The position in the genome of  M. bovis  BCG at which multiple polymorhisms start occurring    
               
               
                   BCG End The position in the genome of  M. bovis  BCG at which multiple polymorhisms end    
               
               
                   H37Rv Start The position in the genome of  M. tuberculosis  H37Rv at which multiple polymorhisms start    
               
               
                   H37Rv End The position in the genome of  M. tuberculosis  H37Rv at multiple polymorhisms end    
               
               
                   C1551 Start The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms start    
               
               
                   CDC1551 End The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms ends    
               
               
                   ORF Indicates whether the polymorphism occurs in an open reading frame (yes) or not (no)    
               
               
                   GO ID The ID for the sequence in the gene ontology database    
               
               
                   Putative function The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0248]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
               
                   
               
               
                   
               
             
             
               
                 a: List of Polymorphisms(Single Nucleotide Polymorphisms) in genes involved in lipid metabolism 
               
             
          
           
               
                 Polymorphism 
                 BCG 
                 BCG 
                 BCG 
                 Query 
                 Query 
                 Query 
                 Query 
                   
                 Type of 
                   
                 Putative 
               
               
                 ID 
                 Position 
                 base 
                 AA 
                 name 
                 Position 
                 base 
                 aa 
                 ORF 
                 SNP 
                 GO ID 
                 Function 
               
               
                   
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 CDC1551 
                 26035 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 69 
                 96136 
                 A 
                 I 
                 H37Rv 
                 96099 
                 G 
                 V 
                 Yes 
                 NS, C 
                 Q10884 
                 Transport 
               
               
                 72 
                 100624 
                 G 
                 A 
                 H37Rv 
                 100587 
                 A 
                 T 
                 Yes 
                 NS, NC 
                 Q10876 
                 Transport 
               
               
                 72 
                 100624 
                 G 
                 A 
                 CDC1551 
                 100579 
                 A 
                 T 
                 Yes 
                 NS, NC 
                 Q10876 
                 Transport 
               
               
                 79 
                 126600 
                 A 
                 S 
                 H37Rv 
                 126561 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q10900 
                 Transport 
               
               
                 79 
                 126600 
                 A 
                 S 
                 CDC1551 
                 126554 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q10900 
                 Transport 
               
               
                 80 
                 126840 
                 G 
                 P 
                 H37Rv 
                 126801 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 Q10900 
                 Transport 
               
               
                 80 
                 126840 
                 G 
                 P 
                 CDC1551 
                 126794 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 Q10900 
                 Transport 
               
               
                 82 
                 130172 
                 A 
                 V 
                 H37Rv 
                 130133 
                 G 
                 A 
                 Yes 
                 NS, C 
                 Q10900 
                 Transport 
               
               
                 82 
                 130172 
                 A 
                 V 
                 CDC1551 
                 130126 
                 G 
                 A 
                 Yes 
                 NS, C 
                 Q10900 
                 Transport 
               
               
                 99 
                 170273 
                 G 
                 L 
                 H37Rv 
                 170081 
                 A 
                 F 
                 Yes 
                 NS, NC 
                 P96820 
                 Transport 
               
               
                 99 
                 170273 
                 G 
                 L 
                 CDC1551 
                 170254 
                 A 
                 F 
                 Yes 
                 NS, NC 
                 P96820 
                 Transport 
               
               
                 123 
                 227215 
                 G 
                 V 
                 H37Rv 
                 227020 
                 A 
                 I 
                 Yes 
                 NS, C 
                 O53645 
                 Transport 
               
               
                 123 
                 227215 
                 G 
                 V 
                 CDC1551 
                 227134 
                 A 
                 I 
                 Yes 
                 NS, C 
                 Q8VKP9 
                 Transport 
               
               
                 124 
                 227738 
                 T 
                 M 
                 H37Rv 
                 227543 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 O53645 
                 Transport 
               
               
                 124 
                 227738 
                 T 
                 M 
                 CDC1551 
                 227657 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 Q8VKP9 
                 Transport 
               
               
                 125 
                 228053 
                 T 
                 L 
                 H37Rv 
                 227858 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 O53645 
                 Transport 
               
               
                 125 
                 228053 
                 T 
                 L 
                 CDC1551 
                 227972 
                 C 
                 P 
                 Yes 
                 NS, NC 
                 Q8VKP9 
                 Transport 
               
               
                 141 
                 262385 
                 A 
                 N 
                 H37Rv 
                 262158 
                 G 
                 D 
                 Yes 
                 NS, NC 
                 P96400 
                 Transport 
               
               
                 141 
                 262385 
                 A 
                 N 
                 CDC1551 
                 262274 
                 G 
                 D 
                 Yes 
                 NS, NC 
                 P96400 
                 Transport 
               
               
                 156 
                 292523 
                 G 
                 A 
                 H37Rv 
                 294196 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 O53666 
                 Transport 
               
               
                 156 
                 292523 
                 G 
                 A 
                 CDC1551 
                 294313 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 O53666 
                 Transport 
               
               
                 157 
                 292778 
                 C 
                 R 
                 H37Rv 
                 294451 
                 T 
                 K 
                 Yes 
                 NS, C 
                 O53666 
                 Transport 
               
               
                 157 
                 292778 
                 C 
                 R 
                 CDC1551 
                 294568 
                 T 
                 K 
                 Yes 
                 NS, C 
                 O53666 
                 Transport 
               
               
                 201 
                 394778 
                 A 
                 Y 
                 H37Rv 
                 393746 
                 G 
                 H 
                 Yes 
                 NS, C 
                 O08447 
                 Transport 
               
               
                 201 
                 394778 
                 A 
                 Y 
                 CDC1551 
                 393808 
                 G 
                 H 
                 Yes 
                 NS, C 
                 O08447 
                 Transport 
               
               
                 218 
                 441762 
                 C 
                 A 
                 H37Rv 
                 440743 
                 T 
                 V 
                 Yes 
                 NS, C 
                 O06312 
                 Transport 
               
               
                 218 
                 441762 
                 C 
                 A 
                 CDC1551 
                 440833 
                 T 
                 V 
                 Yes 
                 NS, C 
                 O06312 
                 Transport 
               
               
                 221 
                 446432 
                 T 
                 S 
                 H37Rv 
                 445413 
                 C 
                 G 
                 Yes 
                 NS, NC 
                 O53703 
                 Transport 
               
               
                 221 
                 446432 
                 T 
                 S 
                 CDC1551 
                 445503 
                 C 
                 G 
                 Yes 
                 NS, NC 
                 O53703 
                 Transport 
               
               
                 222 
                 446797 
                 T 
                 H 
                 H37Rv 
                 445778 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 O53703 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 222 
                 446797 
                 T 
                 H 
                 CDC1551 
                 445868 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 O53703 
                 Transport 
               
               
                 226 
                 452456 
                 G 
                 S 
                 H37Rv 
                 451437 
                 A 
                 F 
                 Yes 
                 NS, NC 
                 O53708 
                 Transport 
               
               
                 226 
                 452456 
                 G 
                 S 
                 CDC1551 
                 451527 
                 A 
                 F 
                 Yes 
                 NS, NC 
                 O53708 
                 Transport 
               
               
                 234 
                 472937 
                 G 
                 A 
                 H37Rv 
                 471916 
                 A 
                 V 
                 Yes 
                 NS, C 
                 P95200 
                 Transport 
               
               
                 234 
                 472937 
                 G 
                 A 
                 CDC1551 
                 472009 
                 A 
                 V 
                 Yes 
                 NS, C 
                 P95200 
                 Transport 
               
               
                 247 
                 502639 
                 T 
                 V 
                 H37Rv 
                 501618 
                 C 
                 A 
                 Yes 
                 NS, C 
                 P96261 
                 Transport 
               
               
                 247 
                 502639 
                 T 
                 V 
                 CDC1551 
                 503069 
                 C 
                 A 
                 Yes 
                 NS, C 
                 P96261 
                 Transport 
               
               
                 250 
                 515676 
                 G 
                 A 
                 H37Rv 
                 514655 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 P96271 
                 Transport 
               
               
                 250 
                 515676 
                 G 
                 A 
                 CDC1551 
                 516106 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 P96271 
                 Transport 
               
               
                 280 
                 582972 
                 A 
                 F 
                 H37Rv 
                 581819 
                 G 
                 L 
                 Yes 
                 NS, NC 
                 Q11157 
                 Transport 
               
               
                 280 
                 582972 
                 A 
                 F 
                 CDC1551 
                 583188 
                 G 
                 L 
                 Yes 
                 NS, NC 
                 Q11157 
                 Transport 
               
               
                 383 
                 846049 
                 C 
                 V 
                 H37Rv 
                 843857 
                 T 
                 I 
                 Yes 
                 NS, C 
                 O53815 
                 Transport 
               
               
                 383 
                 846049 
                 C 
                 V 
                 CDC1551 
                 846000 
                 T 
                 I 
                 Yes 
                 NS, C 
                 O53815 
                 Transport 
               
               
                 384 
                 846399 
                 G 
                 A 
                 H37Rv 
                 844207 
                 A 
                 V 
                 Yes 
                 NS, C 
                 O53815 
                 Transport 
               
               
                 384 
                 846399 
                 G 
                 A 
                 CDC1551 
                 846350 
                 A 
                 V 
                 Yes 
                 NS, C 
                 O53815 
                 Transport 
               
               
                 406 
                 913660 
                 G 
                 L 
                 H37Rv 
                 912828 
                 C 
                 F 
                 Yes 
                 NS, NC 
                 O53832 
                 Transport 
               
               
                 406 
                 913660 
                 G 
                 L 
                 CDC1551 
                 912739 
                 C 
                 F 
                 Yes 
                 NS, NC 
                 O53832 
                 Transport 
               
               
                 468 
                 1041172 
                 C 
                 A 
                 H37Rv 
                 1040704 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 O05870 
                 Transport 
               
               
                 468 
                 1041172 
                 C 
                 A 
                 CDC1551 
                 1040719 
                 A 
                 S 
                 Yes 
                 NS, NC 
                 O05870 
                 Transport 
               
               
                 469 
                 1043636 
                 C 
                 A 
                 H37Rv 
                 1043167 
                 T 
                 V 
                 Yes 
                 NS, C 
                 P15712 
                 Transport 
               
               
                 469 
                 1043636 
                 C 
                 A 
                 CDC1551 
                 1043182 
                 T 
                 V 
                 Yes 
                 NS, C 
                 P15712 
                 Transport 
               
               
                 477 
                 1080631 
                 A 
                 N 
                 H37Rv 
                 1080190 
                 G 
                 D 
                 Yes 
                 NS, NC 
                 P77894 
                 Transport 
               
               
                 477 
                 1080631 
                 A 
                 N 
                 CDC1551 
                 1080205 
                 G 
                 D 
                 Yes 
                 NS, NC 
                 P77894 
                 Transport 
               
               
                 478 
                 1083482 
                 A 
                 H 
                 H37Rv 
                 1083041 
                 C 
                 Q 
                 Yes 
                 NS, NC 
                 P71539 
                 Transport 
               
               
                 478 
                 1083482 
                 A 
                 H 
                 CDC1551 
                 1083056 
                 C 
                 Q 
                 Yes 
                 NS, NC 
                 P71539 
                 Transport 
               
               
                 483 
                 1097474 
                 A 
                 S 
                 H37Rv 
                 1097021 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O53894 
                 Transport 
               
               
                 483 
                 1097474 
                 A 
                 S 
                 CDC1551 
                 1097062 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O53894 
                 Transport 
               
               
                 485 
                 1102935 
                 T 
                 L 
                 H37Rv 
                 1102482 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O53899 
                 Transport 
               
               
                 485 
                 1102935 
                 T 
                 L 
                 CDC1551 
                 1102523 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O53899 
                 Transport 
               
               
                 561 
                 1290071 
                 C 
                 L 
                 H37Rv 
                 1288697 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O06559 
                 Transport 
               
               
                 561 
                 1290071 
                 C 
                 L 
                 CDC1551 
                 1288187 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O06559 
                 Transport 
               
               
                 562 
                 1291161 
                 G 
                 G 
                 H37Rv 
                 1289787 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O06559 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 562 
                 1291161 
                 G 
                 G 
                 CDC1551 
                 1289277 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 O06559 
                 Transport 
               
               
                 563 
                 1295376 
                 T 
                 V 
                 H37Rv 
                 1294002 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O06562 
                 Transport 
               
               
                 563 
                 1295376 
                 T 
                 V 
                 CDC1551 
                 1293492 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O06562 
                 Transport 
               
               
                 567 
                 1307530 
                 C 
                 S 
                 H37Rv 
                 1306279 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 O50431 
                 Transport 
               
               
                 567 
                 1307530 
                 C 
                 S 
                 CDC1551 
                 1305769 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 O50431 
                 Transport 
               
               
                 568 
                 1309207 
                 T 
                 N 
                 H37Rv 
                 1307956 
                 G 
                 T 
                 Yes 
                 NS, C 
                 O50431 
                 Transport 
               
               
                 568 
                 1309207 
                 T 
                 N 
                 CDC1551 
                 1307446 
                 G 
                 T 
                 Yes 
                 NS, C 
                 O50431 
                 Transport 
               
               
                 595 
                 1368728 
                 G 
                 G 
                 H37Rv 
                 1367482 
                 T 
                 W 
                 Yes 
                 NS, NC 
                 O33220 
                 Transport 
               
               
                 595 
                 1368728 
                 G 
                 G 
                 CDC1551 
                 1366972 
                 T 
                 W 
                 Yes 
                 NS, NC 
                 O33220 
                 Transport 
               
               
                 602 
                 1383703 
                 C 
                 R 
                 H37Rv 
                 1382457 
                 T 
                 H 
                 Yes 
                 NS, NC 
                 O50455 
                 Transport 
               
               
                 602 
                 1383703 
                 C 
                 R 
                 CDC1551 
                 1381947 
                 T 
                 H 
                 Yes 
                 NS, NC 
                 O50455 
                 Transport 
               
               
                 609 
                 1396254 
                 G 
                 G 
                 H37Rv 
                 1395008 
                 A 
                 R 
                 Yes 
                 NS, NC 
                 O50465 
                 Transport 
               
               
                 609 
                 1396254 
                 G 
                 G 
                 CDC1551 
                 1394497 
                 A 
                 R 
                 Yes 
                 NS, NC 
                 O50465 
                 Transport 
               
               
                 780 
                 1825125 
                 C 
                 R 
                 H37Rv 
                 1839757 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O06151 
                 Transport 
               
               
                 780 
                 1825125 
                 C 
                 R 
                 CDC1551 
                 1830666 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O06151 
                 Transport 
               
               
                 805 
                 1897364 
                 A 
                 F 
                 H37Rv 
                 1912022 
                 C 
                 V 
                 Yes 
                 NS, NC 
                 O33188 
                 Transport 
               
               
                 805 
                 1897364 
                 A 
                 F 
                 CDC1551 
                 1902826 
                 C 
                 V 
                 Yes 
                 NS, NC 
                 O33188 
                 Transport 
               
               
                 815 
                 1921036 
                 G 
                 A 
                 H37Rv 
                 1935693 
                 T 
                 S 
                 Yes 
                 NS, NC 
                 O33206 
                 Transport 
               
               
                 815 
                 1921036 
                 G 
                 A 
                 CDC1551 
                 1926497 
                 T 
                 S 
                 Yes 
                 NS, NC 
                 O33206 
                 Transport 
               
               
                 816 
                 1921535 
                 A 
                 Q 
                 H37Rv 
                 1936192 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O33206 
                 Transport 
               
               
                 816 
                 1921535 
                 A 
                 Q 
                 CDC1551 
                 1926996 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O33206 
                 Transport 
               
               
                 822 
                 1937372 
                 C 
                 P 
                 H37Rv 
                 1952030 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P71984 
                 Transport 
               
               
                 822 
                 1937372 
                 C 
                 P 
                 CDC1551 
                 1942833 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P71984 
                 Transport 
               
               
                 823 
                 1938167 
                 T 
                 Y 
                 H37Rv 
                 1952825 
                 C 
                 H 
                 Yes 
                 NS, C 
                 P71984 
                 Transport 
               
               
                 823 
                 1938167 
                 T 
                 Y 
                 CDC1551 
                 1943628 
                 C 
                 H 
                 Yes 
                 NS, C 
                 P71984 
                 Transport 
               
               
                 828 
                 1949354 
                 C 
                 G 
                 H37Rv 
                 1963955 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 P71994 
                 Transport 
               
               
                 828 
                 1949354 
                 C 
                 G 
                 CDC1551 
                 1954815 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 P71994 
                 Transport 
               
               
                 829 
                 1949427 
                 G 
                 H 
                 H37Rv 
                 1964028 
                 C 
                 D 
                 Yes 
                 NS, NC 
                 P71994 
                 Transport 
               
               
                 829 
                 1949427 
                 G 
                 H 
                 CDC1551 
                 1954888 
                 C 
                 D 
                 Yes 
                 NS, NC 
                 P71994 
                 Transport 
               
               
                 840 
                 1965950 
                 C 
                 T 
                 H37Rv 
                 1980550 
                 T 
                 M 
                 Yes 
                 NS, NC 
                 O65936 
                 Transport 
               
               
                 840 
                 1965950 
                 C 
                 T 
                 CDC1551 
                 1971410 
                 T 
                 M 
                 Yes 
                 NS, NC 
                 O65936 
                 Transport 
               
               
                 849 
                 2002085 
                 G 
                 Q 
                 H37Rv 
                 2011625 
                 C 
                 H 
                 Yes 
                 NS, NC 
                 O33180 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 849 
                 2002085 
                 G 
                 Q 
                 CDC1551 
                 2009047 
                 C 
                 H 
                 Yes 
                 NS, NC 
                 O33180 
                 Transport 
               
               
                 879 
                 2042298 
                 T 
                 * 
                 H37Rv 
                 2051841 
                 C 
                 Q 
                 Yes 
                 NS, TP 
                 O53958 
                 Transport 
               
               
                 879 
                 2042298 
                 T 
                 * 
                 CDC1551 
                 2049263 
                 C 
                 Q 
                 Yes 
                 NS, TP 
                 Q8VJW0 
                 Transport 
               
               
                 880 
                 2043142 
                 C 
                 S 
                 H37Rv 
                 2052685 
                 G 
                 * 
                 Yes 
                 NS, TP 
                 O53958 
                 Transport 
               
               
                 880 
                 2043142 
                 C 
                 S 
                 CDC1551 
                 2050107 
                 G 
                 * 
                 Yes 
                 NS, TP 
                 Q8VJW0 
                 Transport 
               
               
                 885 
                 2053386 
                 C 
                 V 
                 H37Rv 
                 2062920 
                 T 
                 I 
                 Yes 
                 NS, C 
                 Q50614 
                 Transport 
               
               
                 885 
                 2053386 
                 C 
                 V 
                 CDC1551 
                 2060259 
                 T 
                 I 
                 Yes 
                 NS, C 
                 Q50614 
                 Transport 
               
               
                 886 
                 2054840 
                 G 
                 A 
                 H37Rv 
                 2064374 
                 A 
                 V 
                 Yes 
                 NS, C 
                 Q50614 
                 Transport 
               
               
                 886 
                 2054840 
                 G 
                 A 
                 CDC1551 
                 2061713 
                 A 
                 V 
                 Yes 
                 NS, C 
                 Q50614 
                 Transport 
               
               
                 904 
                 2092402 
                 A 
                 W 
                 H37Rv 
                 2102191 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 P95160 
                 Transport 
               
               
                 904 
                 2092402 
                 A 
                 W 
                 CDC1551 
                 2099413 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 P95160 
                 Transport 
               
               
                 907 
                 2097719 
                 T 
                 M 
                 H37Rv 
                 2107509 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 P95155 
                 Transport 
               
               
                 907 
                 2097719 
                 T 
                 M 
                 CDC1551 
                 2104731 
                 C 
                 T 
                 Yes 
                 NS, NC 
                 P95155 
                 Transport 
               
               
                 914 
                 2112834 
                 G 
                 A 
                 H37Rv 
                 2122623 
                 A 
                 V 
                 Yes 
                 NS, C 
                 P95143 
                 Transport 
               
               
                 914 
                 2112834 
                 G 
                 A 
                 CDC1551 
                 2119846 
                 A 
                 V 
                 Yes 
                 NS, C 
                 P95143 
                 Transport 
               
               
                 915 
                 2113185 
                 G 
                 A 
                 H37Rv 
                 2122974 
                 C 
                 G 
                 Yes 
                 NS, C 
                 P95143 
                 Transport 
               
               
                 915 
                 2113185 
                 G 
                 A 
                 CDC1551 
                 2120197 
                 C 
                 G 
                 Yes 
                 NS, C 
                 P95143 
                 Transport 
               
               
                 929 
                 2141958 
                 T 
                 T 
                 H37Rv 
                 2151676 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O07727 
                 Transport 
               
               
                 929 
                 2141958 
                 T 
                 T 
                 CDC1551 
                 2148969 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O07727 
                 Transport 
               
               
                 930 
                 2145004 
                 A 
                 L 
                 H37Rv 
                 2154722 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 Q08129 
                 Transport 
               
               
                 930 
                 2145004 
                 A 
                 L 
                 CDC1551 
                 2152015 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 Q08129 
                 Transport 
               
               
                 953 
                 2201224 
                 C 
                 G 
                 H37Rv 
                 2222306 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 Q10875 
                 Transport 
               
               
                 953 
                 2201224 
                 C 
                 G 
                 CDC1551 
                 2219640 
                 T 
                 D 
                 Yes 
                 NS, NC 
                 Q10875 
                 Transport 
               
               
                 980 
                 2271395 
                 A 
                 V 
                 H37Rv 
                 2287480 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53485 
                 Transport 
               
               
                 980 
                 2271395 
                 A 
                 V 
                 CDC1551 
                 2289814 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53485 
                 Transport 
               
               
                 1008 
                 2369039 
                 A 
                 D 
                 H37Rv 
                 2388639 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O33261 
                 Transport 
               
               
                 1009 
                 2369143 
                 A 
                 S 
                 H37Rv 
                 2388743 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O33261 
                 Transport 
               
               
                 1009 
                 2369143 
                 A 
                 S 
                 CDC1551 
                 2387320 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O33261 
                 Transport 
               
               
                 1036 
                 2438267 
                 C 
                 I 
                 H37Rv 
                 2459232 
                 G 
                 M 
                 Yes 
                 NS, NC 
                 Q10387 
                 Transport 
               
               
                 1036 
                 2438267 
                 C 
                 I 
                 CDC1551 
                 2456567 
                 G 
                 M 
                 Yes 
                 NS, NC 
                 Q10387 
                 Transport 
               
               
                 1062 
                 2507835 
                 A 
                 V 
                 H37Rv 
                 2528771 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53528 
                 Transport 
               
               
                 1062 
                 2507835 
                 A 
                 V 
                 CDC1551 
                 2526031 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53528 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 1077 
                 2541551 
                 C 
                 A 
                 H37Rv 
                 2563956 
                 A 
                 E 
                 Yes 
                 NS, NC 
                 Q59570 
                 Transport 
               
               
                 1077 
                 2541551 
                 C 
                 A 
                 CDC1551 
                 2559803 
                 A 
                 E 
                 Yes 
                 NS, NC 
                 Q59570 
                 Transport 
               
               
                 1086 
                 2569172 
                 G 
                 V 
                 H37Rv 
                 2591575 
                 C 
                 L 
                 Yes 
                 NS, C 
                 P71894 
                 Transport 
               
               
                 1086 
                 2569172 
                 G 
                 V 
                 CDC1551 
                 2587422 
                 C 
                 L 
                 Yes 
                 NS, C 
                 Q8VJL6 
                 Transport 
               
               
                 1110 
                 2660947 
                 A 
                 N 
                 H37Rv 
                 2692873 
                 G 
                 S 
                 Yes 
                 NS, C 
                 P71748 
                 Transport 
               
               
                 1110 
                 2660947 
                 A 
                 N 
                 CDC1551 
                 2690205 
                 G 
                 S 
                 Yes 
                 NS, C 
                 P71748 
                 Transport 
               
               
                 1112 
                 2661841 
                 G 
                 S 
                 H37Rv 
                 2693770 
                 A 
                 N 
                 Yes 
                 NS, C 
                 P71748 
                 Transport 
               
               
                 1112 
                 2661841 
                 G 
                 S 
                 CDC1551 
                 2691102 
                 A 
                 N 
                 Yes 
                 NS, C 
                 P71748 
                 Transport 
               
               
                 1113 
                 2663078 
                 T 
                 H 
                 H37Rv 
                 2695007 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 P71746 
                 Transport 
               
               
                 1113 
                 2663078 
                 T 
                 H 
                 CDC1551 
                 2692339 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 P71746 
                 Transport 
               
               
                 1138 
                 2729181 
                 A 
                 I 
                 H37Rv 
                 2761016 
                 G 
                 M 
                 Yes 
                 NS, NC 
                 O53186 
                 Transport 
               
               
                 1138 
                 2729181 
                 A 
                 I 
                 CDC1551 
                 2757863 
                 G 
                 M 
                 Yes 
                 NS, NC 
                 O53186 
                 Transport 
               
               
                 1139 
                 2733102 
                 A 
                 L 
                 H37Rv 
                 2764937 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O53189 
                 Transport 
               
               
                 1139 
                 2733102 
                 A 
                 L 
                 CDC1551 
                 2761784 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O53189 
                 Transport 
               
               
                 1192 
                 2880160 
                 G 
                 P 
                 H37Rv 
                 2912710 
                 T 
                 T 
                 Yes 
                 NS, NC 
                 Q50635 
                 Transport 
               
               
                 1192 
                 2880160 
                 G 
                 P 
                 CDC1551 
                 2908855 
                 T 
                 T 
                 Yes 
                 NS, NC 
                 Q50635 
                 Transport 
               
               
                 1193 
                 2880535 
                 T 
                 T 
                 H37Rv 
                 2913085 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q50635 
                 Transport 
               
               
                 1193 
                 2880535 
                 T 
                 T 
                 CDC1551 
                 2909230 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q50635 
                 Transport 
               
               
                 1194 
                 2881707 
                 C 
                 S 
                 H37Rv 
                 2914257 
                 T 
                 N 
                 Yes 
                 NS, C 
                 Q50634 
                 Transport 
               
               
                 1194 
                 2881707 
                 C 
                 S 
                 CDC1551 
                 2910402 
                 T 
                 N 
                 Yes 
                 NS, C 
                 Q50634 
                 Transport 
               
               
                 1216 
                 2935735 
                 C 
                 A 
                 H37Rv 
                 2968270 
                 T 
                 V 
                 Yes 
                 NS, C 
                 P71942 
                 Transport 
               
               
                 1216 
                 2935735 
                 C 
                 A 
                 CDC1551 
                 2964416 
                 T 
                 V 
                 Yes 
                 NS, C 
                 P71942 
                 Transport 
               
               
                 1227 
                 2959751 
                 G 
                 G 
                 H37Rv 
                 3003112 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O07187 
                 Transport 
               
               
                 1227 
                 2959751 
                 G 
                 G 
                 CDC1551 
                 2998058 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O07187 
                 Transport 
               
               
                 1228 
                 2959795 
                 T 
                 C 
                 H37Rv 
                 3003156 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O07187 
                 Transport 
               
               
                 1228 
                 2959795 
                 T 
                 C 
                 CDC1551 
                 2998102 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O07187 
                 Transport 
               
               
                 1230 
                 2963874 
                 G 
                 R 
                 H37Rv 
                 3007235 
                 A 
                 * 
                 Yes 
                 NS, TP 
                 O07192 
                 Transport 
               
               
                 1230 
                 2963874 
                 G 
                 R 
                 CDC1551 
                 3002180 
                 A 
                 * 
                 Yes 
                 NS, TP 
                 O07192 
                 Transport 
               
               
                 1231 
                 2967056 
                 G 
                 V 
                 H37Rv 
                 3010417 
                 A 
                 I 
                 Yes 
                 NS, C 
                 O07194 
                 Transport 
               
               
                 1231 
                 2967056 
                 G 
                 V 
                 CDC1551 
                 3005362 
                 A 
                 I 
                 Yes 
                 NS, C 
                 O07194 
                 Transport 
               
               
                 1242 
                 2993548 
                 G 
                 T 
                 H37Rv 
                 3036909 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 O33229 
                 Transport 
               
               
                 1242 
                 2993548 
                 G 
                 T 
                 CDC1551 
                 3031848 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 O33229 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 1243 
                 2993831 
                 C 
                 A 
                 H37Rv 
                 3037192 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O33229 
                 Transport 
               
               
                 1243 
                 2993831 
                 C 
                 A 
                 CDC1551 
                 3032131 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 O33229 
                 Transport 
               
               
                 1292 
                 3096227 
                 G 
                 P 
                 H37Rv 
                 3139653 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71619 
                 Transport 
               
               
                 1292 
                 3096227 
                 G 
                 P 
                 CDC1551 
                 3133869 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 Q8VJC1 
                 Transport 
               
               
                 1293 
                 3096535 
                 A 
                 L 
                 H37Rv 
                 3139961 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 P71619 
                 Transport 
               
               
                 1294 
                 3096724 
                 A 
                 I 
                 H37Rv 
                 3140150 
                 C 
                 S 
                 Yes 
                 NS, NC 
                 P71619 
                 Transport 
               
               
                 1296 
                 3099150 
                 A 
                 L 
                 H37Rv 
                 3142577 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 P71616 
                 Transport 
               
               
                 1296 
                 3099150 
                 A 
                 L 
                 CDC1551 
                 3136791 
                 G 
                 P 
                 Yes 
                 NS, NC 
                 P71616 
                 Transport 
               
               
                 1332 
                 3192343 
                 C 
                 G 
                 H37Rv 
                 3235712 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 Q10970 
                 Transport 
               
               
                 1332 
                 3192343 
                 C 
                 G 
                 CDC1551 
                 3230035 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 Q10970 
                 Transport 
               
               
                 1333 
                 3193344 
                 C 
                 R 
                 H37Rv 
                 3236713 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 Q10970 
                 Transport 
               
               
                 1333 
                 3193344 
                 C 
                 R 
                 CDC1551 
                 3231036 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 Q10970 
                 Transport 
               
               
                 1345 
                 3229711 
                 G 
                 D 
                 H37Rv 
                 3273135 
                 C 
                 H 
                 Yes 
                 NS, NC 
                 P96205 
                 Transport 
               
               
                 1345 
                 3229711 
                 G 
                 D 
                 CDC1551 
                 3267458 
                 C 
                 H 
                 Yes 
                 NS, NC 
                 P96205 
                 Transport 
               
               
                 1387 
                 3343657 
                 A 
                 V 
                 H37Rv 
                 3387094 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53275 
                 Transport 
               
               
                 1387 
                 3343657 
                 A 
                 V 
                 CDC1551 
                 3382833 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O53275 
                 Transport 
               
               
                 1396 
                 3377371 
                 G 
                 G 
                 H37Rv 
                 3420822 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 P95099 
                 Transport 
               
               
                 1396 
                 3377371 
                 G 
                 G 
                 CDC1551 
                 3416547 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 P95099 
                 Transport 
               
               
                 1416 
                 3430975 
                 A 
                 I 
                 H37Rv 
                 3474424 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O05783 
                 Transport 
               
               
                 1416 
                 3430975 
                 A 
                 I 
                 CDC1551 
                 3470223 
                 G 
                 V 
                 Yes 
                 NS, C 
                 O05783 
                 Transport 
               
               
                 1417 
                 3431707 
                 G 
                 D 
                 H37Rv 
                 3475156 
                 A 
                 N 
                 Yes 
                 NS, NC 
                 O05783 
                 Transport 
               
               
                 1417 
                 3431707 
                 G 
                 D 
                 CDC1551 
                 3470955 
                 A 
                 N 
                 Yes 
                 NS, NC 
                 O05783 
                 Transport 
               
               
                 1447 
                 3476153 
                 G 
                 A 
                 H37Rv 
                 3521041 
                 A 
                 T 
                 Yes 
                 NS, NC 
                 P95173 
                 Transport 
               
               
                 1447 
                 3476153 
                 G 
                 A 
                 CDC1551 
                 3516528 
                 A 
                 T 
                 Yes 
                 NS, NC 
                 P95173 
                 Transport 
               
               
                 1453 
                 3488207 
                 G 
                 L 
                 H37Rv 
                 3530952 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O53311 
                 Transport 
               
               
                 1453 
                 3488207 
                 G 
                 L 
                 CDC1551 
                 3528588 
                 C 
                 V 
                 Yes 
                 NS, C 
                 O53311 
                 Transport 
               
               
                 1454 
                 3489142 
                 T 
                 E 
                 H37Rv 
                 3531888 
                 G 
                 D 
                 Yes 
                 NS, C 
                 O53313 
                 Transport 
               
               
                 1454 
                 3489142 
                 T 
                 E 
                 CDC1551 
                 3529524 
                 G 
                 D 
                 Yes 
                 NS, C 
                 O53313 
                 Transport 
               
               
                 1466 
                 3528181 
                 C 
                 D 
                 H37Rv 
                 3573633 
                 T 
                 N 
                 Yes 
                 NS, NC 
                 O53346 
                 Transport 
               
               
                 1466 
                 3528181 
                 C 
                 D 
                 CDC1551 
                 3568540 
                 T 
                 N 
                 Yes 
                 NS, NC 
                 O53346 
                 Transport 
               
               
                 1479 
                 3562541 
                 A 
                 C 
                 H37Rv 
                 3607938 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O05875 
                 Transport 
               
               
                 1479 
                 3562541 
                 A 
                 C 
                 CDC1551 
                 3602842 
                 G 
                 R 
                 Yes 
                 NS, NC 
                 O05875 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 1482 
                 3569604 
                 T 
                 H 
                 H37Rv 
                 3615000 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 O05884 
                 Transport 
               
               
                 1482 
                 3569604 
                 T 
                 H 
                 CDC1551 
                 3609903 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 Q8VJ44 
                 Transport 
               
               
                 1499 
                 3619961 
                 A 
                 D 
                 H37Rv 
                 3665432 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 P96888 
                 Transport 
               
               
                 1499 
                 3619961 
                 A 
                 D 
                 CDC1551 
                 3660271 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 P96888 
                 Transport 
               
               
                 1511 
                 3644541 
                 G 
                 S 
                 H37Rv 
                 3690012 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 O53355 
                 Transport 
               
               
                 1511 
                 3644541 
                 G 
                 S 
                 CDC1551 
                 3684851 
                 A 
                 L 
                 Yes 
                 NS, NC 
                 Q8VJ36 
                 Transport 
               
               
                 1512 
                 3645379 
                 C 
                 A 
                 H37Rv 
                 3690850 
                 T 
                 T 
                 Yes 
                 NS, NC 
                 O53355 
                 Transport 
               
               
                 1512 
                 3645379 
                 C 
                 A 
                 CDC1551 
                 3685689 
                 T 
                 T 
                 Yes 
                 NS, NC 
                 Q8VJ36 
                 Transport 
               
               
                 1520 
                 3661401 
                 G 
                 E 
                 H37Rv 
                 3706872 
                 C 
                 D 
                 Yes 
                 NS, C 
                 O53371 
                 Transport 
               
               
                 1520 
                 3661401 
                 G 
                 E 
                 CDC1551 
                 3701763 
                 C 
                 D 
                 Yes 
                 NS, C 
                 O53371 
                 Transport 
               
               
                 1587 
                 3816846 
                 A 
                 D 
                 H37Rv 
                 3869141 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 O33354 
                 Transport 
               
               
                 1587 
                 3816846 
                 A 
                 D 
                 CDC1551 
                 3855093 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 O33354 
                 Transport 
               
               
                 1608 
                 3839628 
                 A 
                 V 
                 H37Rv 
                 3893286 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O06339 
                 Transport 
               
               
                 1608 
                 3839628 
                 A 
                 V 
                 CDC1551 
                 3887122 
                 G 
                 A 
                 Yes 
                 NS, C 
                 O06339 
                 Transport 
               
               
                 1609 
                 3839818 
                 A 
                 F 
                 H37Rv 
                 3893476 
                 G 
                 L 
                 Yes 
                 NS, NC 
                 O06339 
                 Transport 
               
               
                 1609 
                 3839818 
                 A 
                 F 
                 CDC1551 
                 3887312 
                 G 
                 L 
                 Yes 
                 NS, NC 
                 O06339 
                 Transport 
               
               
                 1621 
                 3869973 
                 T 
                 V 
                 H37Rv 
                 3924346 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O53550 
                 Transport 
               
               
                 1621 
                 3869973 
                 T 
                 V 
                 CDC1551 
                 3918182 
                 C 
                 A 
                 Yes 
                 NS, C 
                 O53550 
                 Transport 
               
               
                 1638 
                 3947819 
                 G 
                 R 
                 H37Rv 
                 4004600 
                 A 
                 Q 
                 Yes 
                 NS, NC 
                 P96845 
                 Transport 
               
               
                 1638 
                 3947819 
                 G 
                 R 
                 CDC1551 
                 3996744 
                 A 
                 Q 
                 Yes 
                 NS, NC 
                 P96845 
                 Transport 
               
               
                 1639 
                 3948329 
                 C 
                 S 
                 H37Rv 
                 4005110 
                 G 
                 W 
                 Yes 
                 NS, NC 
                 P96845 
                 Transport 
               
               
                 1639 
                 3948329 
                 C 
                 S 
                 CDC1551 
                 3997254 
                 G 
                 W 
                 Yes 
                 NS, NC 
                 P96845 
                 Transport 
               
               
                 1640 
                 3951962 
                 G 
                 T 
                 H37Rv 
                 4008744 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 P96849 
                 Transport 
               
               
                 1640 
                 3951962 
                 G 
                 T 
                 CDC1551 
                 4000886 
                 A 
                 I 
                 Yes 
                 NS, NC 
                 P96849 
                 Transport 
               
               
                 1644 
                 3964308 
                 T 
                 S 
                 H37Rv 
                 4021090 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P96860 
                 Transport 
               
               
                 1644 
                 3964308 
                 T 
                 S 
                 CDC1551 
                 4013232 
                 G 
                 A 
                 Yes 
                 NS, NC 
                 P96860 
                 Transport 
               
               
                 1682 
                 4043080 
                 C 
                 G 
                 H37Rv 
                 4105730 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 1682 
                 4043080 
                 C 
                 G 
                 CDC1551 
                 4097990 
                 T 
                 E 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 1683 
                 4043104 
                 T 
                 Q 
                 H37Rv 
                 4105754 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 1683 
                 4043104 
                 T 
                 Q 
                 CDC1551 
                 4098014 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 1684 
                 4044421 
                 C 
                 R 
                 H37Rv 
                 4107071 
                 T 
                 Q 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 1684 
                 4044421 
                 C 
                 R 
                 CDC1551 
                 4099331 
                 T 
                 Q 
                 Yes 
                 NS, NC 
                 O69634 
                 Transport 
               
               
                 29 
                 26034 
                 G 
                 P 
                 H37Rv 
                 26053 
                 C 
                 A 
                 Yes 
                 NS, NC 
                 P71591 
                 Transport 
               
               
                 1692 
                 4065667 
                 G 
                 Q 
                 H37Rv 
                 4128317 
                 C 
                 E 
                 Yes 
                 NS, NC 
                 O69653 
                 Transport 
               
               
                 1692 
                 4065667 
                 G 
                 Q 
                 CDC1551 
                 4120575 
                 C 
                 E 
                 Yes 
                 NS, NC 
                 O69653 
                 Transport 
               
               
                 1716 
                 4113722 
                 A 
                 R 
                 H37Rv 
                 4176259 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O69695 
                 Transport 
               
               
                 1716 
                 4113722 
                 A 
                 R 
                 CDC1551 
                 4168574 
                 G 
                 G 
                 Yes 
                 NS, NC 
                 O69695 
                 Transport 
               
               
                 1790 
                 4266511 
                 T 
                 H 
                 H37Rv 
                 4330235 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 P96219 
                 Transport 
               
               
                 1790 
                 4266511 
                 T 
                 H 
                 CDC1551 
                 4322561 
                 C 
                 R 
                 Yes 
                 NS, NC 
                 P96219 
                 Transport 
               
               
                 1824 
                 4335857 
                 G 
                 G 
                 H37Rv 
                 4401894 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 P52214 
                 Transport 
               
               
                 1824 
                 4335857 
                 G 
                 G 
                 CDC1551 
                 4394201 
                 A 
                 D 
                 Yes 
                 NS, NC 
                 P52214 
                 Transport 
               
               
                   
               
             
          
           
               
                 b: List of Polymorphisms(Insertions/Deletions) in genes involved in lipid metabolism 
               
             
          
           
               
                 Polymorphism 
                 BCG 
                 BCG 
                 Query 
                 Query 
                 Query 
                   
                   
                 Putative 
               
               
                 ID 
                 start 
                 end 
                 name 
                 start 
                 end 
                 ORF 
                 GO ID 
                 Function 
               
               
                   
               
               
                 1837 
                 82490 
                 82491 
                 H37Rv 
                 82452 
                 82454 
                 Yes 
                 O53618 
                 Transport 
               
               
                 1838 
                 125870 
                 125872 
                 H37Rv 
                 125832 
                 125833 
                 Yes 
                 Q10900 
                 Transport 
               
               
                 1854 
                 257984 
                 258014 
                 H37Rv 
                 257786 
                 257787 
                 Yes 
                 P96397 
                 Transport 
               
               
                 1883 
                 669950 
                 669952 
                 H37Rv 
                 668706 
                 668707 
                 Yes 
                 O53772 
                 Transport 
               
               
                 1902 
                 890037 
                 890038 
                 H37Rv 
                 887845 
                 887847 
                 Yes 
                 O07268 
                 Transport 
               
               
                 1917 
                 1041920 
                 1041922 
                 H37Rv 
                 1041452 
                 1041453 
                 Yes 
                 P95302 
                 Transport 
               
               
                 1919 
                 1087886 
                 1087887 
                 H37Rv 
                 1087445 
                 1087447 
                 Yes 
                 O86319 
                 Transport 
               
               
                 1946 
                 1407255 
                 1407256 
                 H37Rv 
                 1409016 
                 1409018 
                 Yes 
                 Q11058 
                 Transport 
               
               
                 1964 
                 1744186 
                 1744191 
                 H37Rv 
                 1760169 
                 1760170 
                 Yes 
                 Q10761 
                 Transport 
               
               
                 1971 
                 1879687 
                 1879698 
                 H37Rv 
                 1894299 
                 1894300 
                 Yes 
                 O53916 
                 Transport 
               
               
                 1994 
                 2116913 
                 2116915 
                 H37Rv 
                 2126702 
                 2126703 
                 Yes 
                 O07753 
                 Transport 
               
               
                 2006 
                 2184230 
                 2184231 
                 H37Rv 
                 2192593 
                 2192595 
                 Yes 
                 P95275 
                 Transport 
               
               
                 2032 
                 2504789 
                 2504790 
                 H37Rv 
                 2525724 
                 2525726 
                 Yes 
                 O53525 
                 Transport 
               
               
                 2037 
                 2540853 
                 2540854 
                 H37Rv 
                 2563256 
                 2563259 
                 Yes 
                 Q59570 
                 Transport 
               
               
                 2040 
                 2584392 
                 2584410 
                 H37Rv 
                 2606795 
                 2606796 
                 Yes 
                 P71879 
                 Transport 
               
               
                 2044 
                 2661152 
                 2661153 
                 H37Rv 
                 2693078 
                 2693088 
                 Yes 
                 P71748 
                 Transport 
               
               
                 2075 
                 3043634 
                 3043635 
                 H37Rv 
                 3087081 
                 3087083 
                 Yes 
                 P30234 
                 Transport 
               
               
                 2084 
                 3098539 
                 3098540 
                 H37Rv 
                 3141965 
                 3141967 
                 Yes 
                 P71617 
                 Transport 
               
               
                 2099 
                 3381643 
                 3381645 
                 H37Rv 
                 3425094 
                 3425095 
                 Yes 
                 P95097 
                 Transport 
               
               
                 2103 
                 3455437 
                 3456765 
                 H37Rv 
                 3501662 
                 3501663 
                 Yes 
                 P95191 
                 Transport 
               
               
                 2163 
                 3898149 
                 3898150 
                 H37Rv 
                 3954929 
                 3954931 
                 Yes 
                 O53563 
                 Transport 
               
               
                 1837 
                 82490 
                 82491 
                 CDC1551 
                 82444 
                 82446 
                 Yes 
                 O53618 
                 Transport 
               
               
                 1854 
                 257984 
                 258014 
                 CDC1551 
                 257902 
                 257903 
                 Yes 
                 P96397 
                 Transport 
               
               
                 1883 
                 669950 
                 669952 
                 CDC1551 
                 670159 
                 670160 
                 Yes 
                 O53772 
                 Transport 
               
               
                 1902 
                 890037 
                 890038 
                 CDC1551 
                 889115 
                 889117 
                 Yes 
                 Q8VKD9 
                 Transport 
               
               
                 1917 
                 1041920 
                 1041922 
                 CDC1551 
                 1041467 
                 1041468 
                 Yes 
                 P95302 
                 Transport 
               
               
                 1919 
                 1087886 
                 1087887 
                 CDC1551 
                 1087460 
                 1087462 
                 Yes 
                 O86319 
                 Transport 
               
               
                 1946 
                 1407255 
                 1407256 
                 CDC1551 
                 1408505 
                 1408507 
                 Yes 
                 Q11058 
                 Transport 
               
               
                 1964 
                 1744186 
                 1744191 
                 CDC1551 
                 1760325 
                 1760326 
                 Yes 
                 Q10761 
                 Transport 
               
               
                 1994 
                 2116913 
                 2116915 
                 CDC1551 
                 2123925 
                 2123926 
                 Yes 
                 O07753 
                 Transport 
               
               
                 2006 
                 2184230 
                 2184231 
                 CDC1551 
                 2189926 
                 2189928 
                 Yes 
                 P95275 
                 Transport 
               
               
                 2037 
                 2540853 
                 2540854 
                 CDC1551 
                 2559103 
                 2559106 
                 Yes 
                 Q59570 
                 Transport 
               
               
                 2040 
                 2584392 
                 2584410 
                 CDC1551 
                 2602641 
                 2602642 
                 Yes 
                 P71879 
                 Transport 
               
               
                 2044 
                 2661152 
                 2661153 
                 CDC1551 
                 2690410 
                 2690420 
                 Yes 
                 P71748 
                 Transport 
               
               
                 2075 
                 3043634 
                 3043635 
                 CDC1551 
                 3081806 
                 3081808 
                 Yes 
                 P30234 
                 Transport 
               
               
                 2084 
                 3098539 
                 3098540 
                 CDC1551 
                 3136179 
                 3136181 
                 Yes 
                 P71617 
                 Transport 
               
               
                 2099 
                 3381643 
                 3381645 
                 CDC1551 
                 3420887 
                 3420888 
                 Yes 
                 P95097 
                 Transport 
               
               
                 2102 
                 3441287 
                 3441288 
                 CDC1551 
                 3480536 
                 3483302 
                 Yes 
                 O05793 
                 Transport 
               
               
                 2163 
                 3898149 
                 3898150 
                 CDC1551 
                 3947715 
                 3947717 
                 Yes 
                 O53563 
                 Transport 
               
               
                   
               
             
          
         
       
     
         [0249]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                   
               
               
                 List of Polymorphisms in genes encoding membrane transport proteins 
               
             
          
           
               
                   
                 BCG 
                 BCG 
                 BCG 
                 Query 
                 Query 
                 Query 
                 Query 
                   
                 Type of 
                   
                 Putative 
               
               
                 Polymorphism ID 
                 Position 
                 base 
                 AA 
                 name 
                 Position 
                 base 
                 aa 
                 ORF 
                 SNP 
                 GO ID 
                 Function 
               
               
                   
               
               
                 632 
                 1457413 
                 G 
                 G 
                 H37Rv 
                 1459362 
                 T 
                 V 
                 Yes 
                 NS, C 
                 Q10606 
                 Lipid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Metabolism 
               
               
                 632 
                 1457413 
                 G 
                 G 
                 CDC1551 
                 1458905 
                 T 
                 V 
                 Yes 
                 NS, C 
                 Q10606 
                 Lipid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Metabolism 
               
               
                   
               
               
                   Table VII: List of long polymorphisms in genes encoding membrane transport proteins    
               
               
                   Polymorphism ID The ID by which the polymorphism can be identified    
               
               
                   BCG Start The position in the genome of  M. bovis  BCG at which multiple polymorhisms start occurring    
               
               
                   BCG End The position in the genome of  M. bovis  BCG at which multiple polymorhisms end    
               
               
                   H37Rv Start The position in the genome of  M. tuberculosis  H37Rv at which multiple polymorhisms start    
               
               
                   H37Rv End The position in the genome of  M. tuberculosis  H37Rv at multiple polymorhisms end    
               
               
                   C1551 Start The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms start    
               
               
                   CDC1551 End The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms ends    
               
               
                   ORF Indicates whether the polymorphism occurs in an open reading frame (Yes) or not (no)    
               
               
                   GO ID The ID for the sequence in the gene ontology database    
               
               
                   Putative function The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0250]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                   
               
               
                 List of Polymorphisms in genes implicated in virulence 
               
             
          
           
               
                 Polymorphism 
                 Gene 
                 BCG 
                 BCG 
                 BCG 
                 Query 
                 Query 
                 Query 
                 Query 
                   
                 is 
                 Is non- 
                   
                 Putative 
               
               
                 ID 
                 name 
                 Position 
                 base 
                 AA 
                 Name 
                 position 
                 base 
                 AA 
                 ORF 
                 nsSNP 
                 cons 
                 GO ID 
                 Function 
               
               
                   
               
             
          
           
               
                 285 
                 proC 
                 591914 
                 C 
                 D 
                 H37Rv 
                 590761 
                 G 
                 E 
                 Yes 
                 NS 
                 C 
                 Q11141 
                 oxidoreductase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 285 
                 proC 
                 591914 
                 C 
                 D 
                 CDC1551 
                 592131 
                 G 
                 E 
                 Yes 
                 NS 
                 C 
                 Q11141 
                 oxidoreductase 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 activity 
               
               
                 1348 
                 fadD28 
                 3239912 
                 T 
                 I 
                 H37Rv 
                 3283336 
                 G 
                 S 
                 Yes 
                 NS 
                 NC 
                 P96290 
                 calcium ion 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 binding activity 
               
               
                 1348 
                 fadD28 
                 3239912 
                 T 
                 I 
                 CDC1551 
                 3277659 
                 G 
                 S 
                 Yes 
                 NS 
                 NC 
                 P96290 
                 calcium ion 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 binding activity 
               
               
                 1349 
                 fadD28 
                 3240065 
                 G 
                 R 
                 H37Rv 
                 3283489 
                 A 
                 Q 
                 Yes 
                 NS 
                 NC 
                 P96290 
                 calcium ion 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 binding activity 
               
               
                 1349 
                 fadD28 
                 3240065 
                 G 
                 R 
                 CDC1551 
                 3277812 
                 A 
                 Q 
                 Yes 
                 NS 
                 NC 
                 P96290 
                 calcium ion 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 binding activity 
               
               
                 1350 
                 fadD28 
                 3240165 
                 C 
                 G 
                 H37Rv 
                 3283589 
                 G 
                 G 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1350 
                 fadD28 
                 3240165 
                 C 
                 G 
                 CDC1551 
                 3277912 
                 G 
                 G 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1351 
                 mmpL7 
                 3242680 
                 A 
                 V 
                 H37Rv 
                 3286104 
                 C 
                 V 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1351 
                 mmpL7 
                 3242680 
                 A 
                 V 
                 CDC1551 
                 3280427 
                 C 
                 V 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1352 
                 mmpL7 
                 3243139 
                 T 
                 A 
                 H37Rv 
                 3286563 
                 C 
                 A 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1352 
                 mmpL7 
                 3243139 
                 T 
                 A 
                 CDC1551 
                 3280886 
                 C 
                 A 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 274 
                 pcaA 
                 561876 
                 G 
                 L 
                 H37Rv 
                 560855 
                 C 
                 L 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 274 
                 pcaA 
                 561876 
                 G 
                 L 
                 CDC1551 
                 562305 
                 C 
                 L 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 275 
                 pcaA 
                 562317 
                 T 
                 A 
                 H37Rv 
                 561296 
                 C 
                 A 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 275 
                 pcaA 
                 562317 
                 T 
                 A 
                 CDC1551 
                 562746 
                 C 
                 A 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1561 
                 dnaE2 
                 3736194 
                 A 
                 S 
                 H37Rv 
                 3782550 
                 G 
                 S 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1561 
                 dnaE2 
                 3736194 
                 A 
                 S 
                 CDC1551 
                 3774786 
                 G 
                 S 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1562 
                 dnaE2 
                 3736445 
                 T 
                 R 
                 H37Rv 
                 3782801 
                 G 
                 R 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                 1562 
                 dnaE2 
                 3736445 
                 T 
                 R 
                 CDC1551 
                 3775037 
                 G 
                 R 
                 Yes 
                 S 
                 Null 
                 Null 
                 Null 
               
               
                   
               
               
                   Table VIII: List of long polymorphisms in genes implicated in virulence    
               
               
                   Polymorphism ID The ID by which the polymorphism can be identified    
               
               
                   BCG Start The position in the genome of  M. bovis  BCG at which multiple polymorhisms start occurring    
               
               
                   BCG End The position in the genome of  M. bovis  BCG at which multiple polymorhisms end    
               
               
                   H37Rv Start The position in the genome of  M. tuberculosis  H37Rv at which multiple polymorhisms start    
               
               
                   H37Rv End The position in the genome of  M. tuberculosis  H37Rv at multiple polymorhisms end    
               
               
                   C1551 Start The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms start    
               
               
                   CDC1551 End The position in the genome of  M. tuberculosis  CDC1551 at which multiple polymorhisms ends    
               
               
                   ORF Indicates whether the polymorphism occurs in an open reading frame (Yes) or not (no)    
               
               
                   GO ID The ID for the sequence in the gene ontology database    
               
               
                   Putative function The putative function of the gene in which the SNP occurs.    
               
             
          
         
       
     
         [0251]