Abstract:
The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

Description:
TECHNICAL FIELD 
       [0001]    The present invention relates to a composition for promoting humoral immunity induction containing a Th2 reaction promoter and a vaccine pharmaceutical composition for humoral immunity induction containing the composition for promoting humoral immunity induction. 
       BACKGROUND ART 
       [0002]    Common widely used vaccines are made from pathogens (e.g., microorganisms, viruses) or such pathogens whose toxicity is partially weakened or eliminated. The vaccines are administered to living bodies to induce immunity to prevent infectious diseases. 
         [0003]    Dendritic cells after having engulfed viruses, microorganisms, or like foreign bodies migrate to lymph nodes and give naive T cells (Th0 cells) the information of the foreign bodies, thus inducing the differentiation of helper T cells. Through the interaction with dendritic cells, Th0 cells differentiate into type 1 helper T cells (Th1 cells), which are responsible for cellular immunity, and type 2 helper T cells (Th2 cells), which are responsible for humoral immunity (see Non-Patent Literature 1, for example). 
         [0004]    Many toll-like receptors (TLRs) are expressed in immunocompetent cells responsible for the innate immunity system, including dendritic cells. They are activated upon receiving a TLR ligand and promote the differentiation of helper T cells, thus inducing an effective immune reaction (see Non-Patent Literature 2, for example). For immunity activation, only the reaction routes via TLRs have been known, and other reaction routes have remained unclear. 
         [0005]    It is known that the direction of the differentiation of helper T cells is controllable with biological signaling molecules such as cytokines. Such control is widely employed in in vitro testing systems. The dendritic cells are activated by stimuli such as cytokines and assumed to determine the direction of the helper T cell differentiation through complicated signal transduction. That is, the “state” of dendritic cells decides the differentiation of T cells, leading to the induction of the cellular immunity or the humoral immunity. The former, where Th 1 cells serve as the center of the reaction, is called Th1 reaction. Similarly, the latter is called Th2 reaction (see Non-Patent Literature 3, for example). 
         [0006]    The promotion of immune reactions via TLRs as described above has been known, but promotion of a humoral immune response (Th2 reaction) via other reactions, that is, reactions not involving TLR stimuli by TLR ligands, has yet to be reported. 
         [0007]    It is known that immunity activation effects can be given by toxins such as cholera toxin or  Escherichia coli  heat-labile enterotoxin or fat/oil adjuvants that enhance the effects of immune reactions by slow-release of antigens. However, they have problems in terms of the balance between the safety and the efficacy (see Non-Patent Literature 4, for example). Thus, adjuvants capable of activating immunity while ensuring safety are demanded. 
       CITATION LIST 
     Non Patent Literature 
       [0000]    
       
         Non-Patent Literature 1: Lipscomb M F. et al., Physiol Rev., 82, 97-130 (2002) 
         Non-Patent Literature 2: Mazzoni A. et al., J Leukoc Biol., 75, 721-730 (2004) 
         Non-Patent Literature 3: Zhou L. et al., Immunity, 30, 646-655 (2009) 
         Non-Patent Literature 4: Stevceva L. et al., Curr Pharm Des, 11, 801-811 (2005) 
       
     
       SUMMARY OF INVENTION 
     Technical Problem 
       [0012]    In view of the situation in the art mentioned above, the present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition which are universally usable for various antigens in the induction of humoral immunity to antigens, contain a Th2 reaction promoter, and exert a high humoral immunity inducing effect. 
       Solution to Problem 
       [0013]    The present inventors found out that applying an external stimulus to a dendritic cell using a specific drug when the cell engulfs an antigen can promote the Th2 reaction, allowing promotion of induction of humoral immunity. This is presumably because such a stimulus causes signal transduction in the dendritic cell to activate the cell, thus leading to induction of humoral immunity. This enables promotion of induction of humoral immunity via a reaction not involving a TLR stimulus by a TLR ligand. 
         [0014]    Specifically, the above specific drug may be a drug that promotes the synthesis, or reduce the decomposition, of cyclic AMP (cAMP), which is responsible for signal transduction in cells, or a drug that suppresses a stimulus to phospholipase C (PLC). 
         [0015]    Accordingly, the present invention found out that direct administration of a specific drug that promotes Th2 reaction together with or separately from an antigen to the same site or different sites of a living body enables effective induction of antigen-specific humoral immunity via a reaction not involving a TLR stimulus by a TLR ligand. 
         [0016]    One aspect of the present invention provides a composition for promoting humoral immunity induction containing a Th2 reaction promoter. 
         [0017]    The Th2 reaction promoter in the composition for promoting humoral immunity induction of the present invention is preferably at least one of a phosphodiesterase inhibitor or a G protein-coupled receptor ligand. 
         [0018]    The Th2 reaction promoter of the composition for promoting humoral immunity induction of the present invention is preferably at least one selected from the group consisting of a drug that promote synthesis of cyclic AMP (cAMP), a drug that reduces decomposition of cyclic AMP (cAMP), and a drug that suppresses a stimulus to phospholipase C (PLC). 
         [0019]    In the composition for promoting humoral immunity induction of the present invention, the drug that promotes synthesis of cyclic AMP (cAMP) is preferably at least one selected from the group consisting of an adrenergic receptor ligand, a muscarinic receptor ligand, a dopamine receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, and a vasopressin receptor ligand, the drug that reduces decomposition of cyclic AMP (cAMP) is preferably at least one selected from the group consisting of a phosphodiesterase inhibitor, an adrenergic receptor ligand, a muscarinic receptor ligand, a dopamine receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, a PAF receptor ligand, a purine receptor ligand, an opioid receptor ligand, a leukotriene receptor ligand, and an angiotensin receptor ligand, and the drug that suppresses a stimulus to phospholipase C (PLC) is preferably at least one selected from the group consisting of an adrenergic receptor ligand, a muscarinic receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, a PAF receptor ligand, a vasopressin receptor ligand, a leukotriene receptor ligand, and an angiotensin receptor ligand. 
         [0020]    Another aspect of the present invention provides a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and the composition for promoting humoral immunity induction. 
         [0021]    The vaccine pharmaceutical composition of the present invention is preferably administered to a body surface. 
         [0022]    The vaccine pharmaceutical composition of the present invention is preferably administered by intradermal injection, subcutaneous injection, or intramuscular injection. 
         [0023]    The present invention will be described below. 
         [0024]    The composition for promoting humoral immunity induction and vaccine pharmaceutical composition of the present invention are used for humoral immunity induction. 
         [0025]    The vaccine pharmaceutical composition of the present invention contains an antigen for inducing humoral immunity and the composition for promoting humoral immunity induction in combination, so that it can effectively induce humoral immunity. The antigen and the composition for promoting humoral immunity induction may be contained together in a formulation, or may be in different formulations and used in combination. 
         [0026]    The humoral immunity inducing effect may be quantitatively determined by any method. Various methods have been developed. For example, the effect can be determined by an immunity induction test using an animal model for immunity evaluation and ELISA (antigen-specific IgG antibody). The sample for determining humoral immunity may be, for example, blood of the animal model for immunity evaluation. 
         [0027]    As used herein, the term “composition for promoting humoral immunity induction” means any substance that can improve the efficiency to induce humoral immunity to an antigen administered with the substance, as compared to the efficiency obtained without the substance. The substance is not limited by the mechanism of promoting humoral immunity induction, but the term means those specified herein. 
         [0028]    As used herein, the term “Th2 reaction promoter” means a substance that promotes the entire series of Th2 reactions that induce the differentiation of a Th0 cell into a Th2 cell for antibody production. Specifically, the term means a drug that increases cAMP or suppresses PLC. 
         [0029]    The Th2 reaction promoter is preferably a phosphodiesterase inhibitor and/or a G protein-coupled receptor ligand. In the present invention, any G protein-coupled receptor ligand can be used, but preferably a G protein-coupled receptor agonist and/or a G protein-coupled receptor antagonist are/is used because in such a case a phosphodiesterase inhibitor or a ligand for a G protein-coupled receptor can be used to increase the intracellular cAMP concentration and an antagonist for a G protein-coupled receptor can be used to suppress PLC. 
         [0030]    In one preferred embodiment, the composition for promoting humoral immunity induction contains the Th2 reaction promoter in which the drug that promotes synthesis of cyclic AMP (cAMP) is at least one selected from the group consisting of an adrenergic receptor ligand, a muscarinic receptor ligand, a dopamine receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, and a vasopressin receptor ligand, the drug that reduces decomposition of cyclic AMP (cAMP) is at least one selected from the group consisting of a phosphodiesterase inhibitor, an adrenergic receptor ligand, a muscarinic receptor ligand, a dopamine receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, a PAF receptor ligand, a purine receptor ligand, an opioid receptor ligand, a leukotriene receptor ligand, and an angiotensin receptor ligand, and the drug that suppresses a stimulus to phospholipase C (PLC) is at least one selected from the group consisting of an adrenergic receptor ligand, a muscarinic receptor ligand, a histamine receptor ligand, a serotonin receptor ligand, a PAF receptor ligand, a vasopressin receptor ligand, a leukotriene receptor ligand, and an angiotensin receptor ligand. 
         [0031]    As used herein, the term “phosphodiesterase inhibitor” means a substance that inhibits the function of a phosphodiesterase (PDE) that decomposes cAMP. The phosphodiesterase inhibitor is also referred to as “PDE inhibitor”. Some PDE inhibitors selectively act on specific phosphodiesterases (phosphodiesterases have subtypes such as PDE1 and PDE2.), and others have no selectivity. Examples of PDE inhibitors usable in the present invention include aminophylline, theophylline, pentoxifylline, proxyphylline, caffeine, IBMX, resveratrol, vinpocetine, EHNA, amrinone, milrinone, olprinone, cilostazol, enoximone, pimobendan, vesnarinone, bucladesine, quazinone, trequinsin, anagrelide, cilostamide, siguazodan, zardaverine, KMUP-1, RPL-554, rolipram, roflumilast, cilomilast, arofylline, ibudilast, denbutyline, drotaverine, etazolate, filaminast, glaucine, irsogladine, mesembrine, piclamilast, OPC6535, R020-1724, CP-80633, HT-0712, ICI-63197, RPL-554, YM-976, ASB16165, BRL50481, papaverine, tofisopam, SCH51866, dipyridamole, zaprinast, and derivatives thereof, and pharmacologically acceptable salts thereof. In a preferred embodiment of the present invention, the PDE inhibitor is resveratrol, vinpocetine, EHNA, cilostazol, pimobendan, BRL50481, and/or dipyridamole. 
         [0032]    As used herein, the term “G protein-coupled receptor (GPCR)” herein means a substance which is a 7-transmembrane receptor localized in the cell membrane and is coupled to a G protein present on the inner side of the cell membrane so as to transduce signals in communication via extracellular neurotransmitters or the like. G proteins are trimeric proteins consisting of Gα, Gβ, and Gγ. Binding of a ligand to the GPCR causes dissociation into the GPCR, Gα, and a Gβγ complex. Gα is involved with an increase in cAMP and activation of PLC. Gα is largely divided into three subunits: Gs, which activates adenylate cyclase to promote the synthesis of cAMP; Gs, which suppresses the synthesis of cAMP; and Gq, which activates PLC. Accordingly, in order to increase cAMP, an agonist for a Gs-coupled GPCR or an antagonist for a Gi-coupled GPCR is used. In order to suppress PLC activation, an antagonist for a Gq-coupled GPCR is used. 
         [0033]    In the present invention, the agonist for the G protein-coupled receptor and the antagonist for the G protein-coupled receptor are each at least one selected from the group consisting of an adrenergic receptor agonist, an adrenergic receptor antagonist, a muscarinic receptor agonist, a muscarinic receptor antagonist, a dopamine receptor agonist, a dopamine receptor antagonist, a histamine receptor agonist, a histamine receptor antagonist, a serotonin receptor agonist, a serotonin receptor antagonist, a PAF receptor antagonist, a purine receptor antagonist, a vasopressin receptor agonist, a vasopressin receptor antagonist, an opioid receptor antagonist, a leukotriene receptor antagonist, and an angiotensin receptor antagonist. Table 1 shows the types and subtypes of GPCRs for Th2 reaction promotion, Gα, and the relation of the GPCRs with agonists/antagonists. 
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                   
                   
                 Th2 
               
               
                 GPCR 
                 Subtype 
                 Gα 
                 Transduction mechanism 
                 promotion 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Adrenaline 
                 α1 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                   
                 α2 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                   
                 β1,2,3 
                 Gs 
                 ↑ cAMP 
                   
                 Agonist 
               
               
                 Muscarine 
                 M1,3,5 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                   
                 M2,4 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                 Dopamine 
                 D1,5 
                 Gs 
                 ↑ cAMP 
                   
                 Agonist 
               
               
                   
                 D2,3,4 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                 Histamine 
                 H1 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                   
                 H2 
                 Gs 
                 ↑ cAMP 
                   
                 Agonist 
               
               
                   
                 H3,4 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                 Serotonin 
                 5-HT4,6,7 
                 Gs 
                 ↑ cAMP 
                   
                 Agonist 
               
               
                   
                 5-HT1,5 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                   
                 5-HT2 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                 PAF 
                 — 
                 Gi &amp; 
                 ↓ cAMP 
                 ↑ PLC 
                 Antagonist 
               
               
                   
                   
                 Gq 
               
               
                 Purine 
                 P2Y12 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                 Vasopressin 
                 V1 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                   
                 V2 
                 Gs 
                 ↑ cAMP 
                   
                 Agonist 
               
               
                 Opioid 
                 μ, κ, σ 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                 Leukotriene 
                 BLT 
                 Gq &amp; 
                 ↓ cAMP 
                 ↑ PLC 
                 Antagonist 
               
               
                   
                   
                 Gi 
               
               
                   
                 CysLT 
                 Gi &amp; 
                 ↓ cAMP 
                 ↑ PLC 
                 Antagonist 
               
               
                   
                   
                 Gq 
               
               
                 Angiotensin 
                 AT1 
                 Gq 
                 ↑ PLC 
                   
                 Antagonist 
               
               
                   
                 AT2 
                 Gi 
                 ↓ cAMP 
                   
                 Antagonist 
               
               
                   
               
             
          
         
       
     
         [0034]    In the present invention, any adrenergic receptor ligand can be used. An adrenergic receptor agonist and/or an adrenergic receptor antagonist can preferably be used. As used herein, the term “adrenergic receptor agonist” means a substance that itself has a function to act on adrenergic receptors. Examples thereof include β1 receptor agonists, β2 receptor agonists, and β3 receptor agonists. Among the adrenergic receptor subtypes, β1, β2, and β3 are coupled to Gs. 
         [0035]    As used herein, the term “adrenergic receptor antagonist” means a substance that itself has a function to inhibit action on adrenergic receptors. Examples thereof include α1 receptor antagonists and α2 receptor antagonists. Among the adrenergic receptor subtypes, al is coupled to Gq, and α2 is coupled to Gi. 
         [0036]    As used herein, the term “β1 receptor agonist” means a substance that itself has a function to act on β1 receptors. The term “β2 receptor agonist” means a substance that itself has a function to act on β2 receptors. The term “β3 receptor agonist” means a substance that itself has a function to act on β3 receptors. Examples of the pi receptor agonists, β2 receptor agonists, and/or β3 receptor agonists include isoprenaline, dobutamine, ephedrine, cimaterol, denopamine, dipivefrine, isoxsuprine, ritodrine, fenoterol, orciprenaline, salbutamol, terbutaline, trimetoquinol, tulobuterol, salmeterol, formoterol, clenbuterol, procaterol, indacaterol, methoxyphenamine, clorprenaline, levarterenol, zinterol, amibegron, mirabegron, ritobegron, solabecron, BRL 37344, CL 316243, ICI 215001, SR 58611A, ZD 2079, ZD 7114, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0037]    As used herein, the term “α1 receptor antagonist” means a substance that itself has a function to inhibit action on al receptors. The term “α2 receptor antagonist” means a substance that itself has a function to inhibit action on α2 receptors. Examples of the al receptor antagonists and/or α2 receptor antagonists include tamsulosin, prazosin, indoramin, trimazosin, doxazosin, urapidil, ketanserin, phentolamine, tolazoline, nicergoline, moxisylyte, ifenprodil, alfuzosin, terazosin, silodosin, ergotamine, risperidone, mianserin, bunazosin, setiptiline, BE 2254, 2-MPMDQ, 2-PMDQ, Rec 15/2615, RS 100329, RS 17053, SNAP 5089, WB 4101, imiloxan, phenoxybenzamine, yohimbine, chlorpromazine, asenapine, mirtazapine, aptazapine, atipamezole, delequamine, setiptiline, A 80426, ARC 239, BRL 44408, efaroxan, idazoxan, imiloxan, JP 1302, rauwolscine, RS 79948, RX 821002, SKF 86466, spiroxatrine, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0038]    In the present invention, any muscarinic receptor ligand can be used. A muscarinic receptor antagonist can preferably be used. 
         [0039]    As used herein, the term “muscarinic receptor antagonist” means a substance that itself has a function to inhibit action on muscarinic receptors. Examples thereof include M1 receptor antagonists, M2 receptor antagonists, M3 receptor antagonists, M4 receptor antagonists, and M5 receptor antagonists. Among the muscarinic receptor subtypes, M1, M3, and M5 are coupled to Gq, and M2 and M4 are coupled to Gi. 
         [0040]    As used herein, the term “M1 receptor antagonist” means a substance that itself has a function to inhibit action on M1 receptors. The term “M2 receptor antagonist” means a substance that itself has a function to inhibit action on M2 receptors. The term “M3 receptor antagonist” means a substance that itself has a function to inhibit action on M3 receptors. The term “M4 receptor antagonist” means a substance that itself has a function to inhibit action on M4 receptors. The term “M5 receptor antagonist” means a substance that itself has a function to inhibit action on M5 receptors. Examples of the M1 receptor antagonists, M2 receptor antagonists, M3 receptor antagonists, M4 receptor antagonists and/or M5 receptor antagonists include trimebutine, piperidolate, propantheline, methanthelinium, tridihexethyl, isopropamide, hexocyclium, mepenzolate, tiemonium, prifinium, timepidium, scopolamine, atoropine, hyoscyamine, fentonium, cimetropium, propiverine, trospium, fesoterodine, orphenadrine, trihexyphenidyl, metixene, procyclidine, profenamine, dexetimide, mazaticol, benztropine, ethybenztropine, ipratropium, oxitropium, cyclopentolate, homatropine, acridinium, benzetimide, butropium, darotropium, diphenylpiperidinomethyldioxolan, diponium, etomidoline, eucatropine, flutropium, methylbenactyzium, methyloctatropine, oxapium, pipethanate, piroheptine, umeclidinium, valethamate, pirenzepine, dicycloverine, dicylomine, acotiamide, imidafenacin, biperiden, nitrocaramiphen, telenzepine, VU 0255035, oxybutynin, esoxybutynin, tripitramine, dimethindene, AF-DX 116, AF-DX 384, AQ-RA 741, oxyphencyclimine, camylofine, glycopyrronium, tolterodine, solifenacin, darifenacin, tiotropium, tiquizium, 4-DAMP, DAU 5884 hydrochloride, J 104129 fumarate, zamifenacin, tropicamide, PD 102807, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0041]    In the present invention, any dopamine receptor ligand can be used. A dopamine receptor agonist and/or a dopamine receptor antagonist can preferably be used. 
         [0042]    As used herein, the term “dopamine receptor agonist” means a substance that itself has a function to act on dopamine receptors. Examples thereof include D1 receptor agonists and D5 receptor agonists. Among the dopamine receptor subtypes, D1 and D5 are coupled to Gs. 
         [0043]    As used herein, the term “dopamine receptor antagonist” means a substance that itself has a function to inhibit action on dopamine receptors. Examples thereof include D2 receptor antagonists, D3 receptor antagonists, and D4 receptor antagonists. Among the dopamine receptor subtypes, D2, D3, and D4 are coupled to Gi. 
         [0044]    As used herein, the term “D1 receptor agonist” means a substance that itself has a function to act on D1 receptors. The term “D5 receptor agonist” means a substance that itself has a function to act on D5 receptors. Examples of the D1 receptor agonists and/or the D5 receptor agonist include fenoldopam, adrogolide, A 68930 hydrochloride, A 77636 hydrochloride, CY 208-243, dihydrexidine hydrochloride, SKF 81297 hydrobromide, SKF 83822 hydrobromide, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0045]    As used herein, the term “D2 receptor antagonist” means a substance that itself has a function to inhibit action on D2 receptors. The term “D3 receptor antagonist” means a substance that itself has a function to inhibit action on D3 receptors. The term “D4 receptor antagonist” means a substance that itself has a function to inhibit action on D4 receptors. Examples of the D2 receptor antagonists, the D3 receptor antagonists, and/or D4 receptor antagonists include metoclopramide, domperidone, bromopride, alizapride, metopimazine, chlorpromazine, levomepromazine, promazine, triflupromazine, fluphenazine, perphenazine, prochlorperazine, thioridazine, haloperidol, trifluperidol, moperone, pipamperone, bromperidol, droperidol, molindone, sertindole, ziprasidone, pimozide, loxapine, clozapine, olanzapine, quetiapine, asenapine, sulpiride, sultopride, tiapride, remoxipride, levosulpiride, risperidone, mosapramine, zotepine, paliperidone, opipramol, aplindore, bifeprunox, blonanserin, cariprazine, clocapramine, iloperidone, mazapertine, methoxypromazine maleate, nemonapride, perospirone, piquindone, spiperone, timiperone, tiospirone, raclopride, eticlopride hydrochloride, GR 103691, nafadotride, NGB 2904, PG 01037 dihydrochloride, PNU 177864 hydrochloride, SB 277011A dihydrochloride, U 99194 maleate, fananserin, sonepiprazole, L-741, 742 hydrochloride, L-745, 870 trihydrochloride, PD 168568 dihydrochloride, PNU 96415E, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0046]    In the present invention, any histamine receptor ligand can be used. A histamine receptor agonist and/or a histamine receptor antagonist can preferably be used. 
         [0047]    As used herein, the term “histamine receptor agonist” means a substance that itself has a function to act on histamine receptors. Examples thereof include H2 receptor agonists. Among the histamine receptor subtypes, H2 is coupled to Gs. 
         [0048]    As used herein, the term “histamine receptor antagonist” means a substance that itself has a function to inhibit action on histamine receptors. Examples thereof include H1 receptor antagonists, H3 receptor antagonists, and H4 receptor antagonists. Among the histamine receptor subtypes, H1 is coupled to Gq, and H3 and H4 are coupled to Gi. 
         [0049]    As used herein, the term “H2 receptor agonist” means a substance that itself has a function to act on H2 receptors. Examples of the H2 receptor agonists include impromidine hydrochloride, amthamine dihydrobromide, dimaprit dihydrochloride, HTMT dimaleate, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0050]    As used herein, the term “H1 receptor antagonist” means a substance that itself has a function to inhibit action on H1 receptors. The term “H3 receptor antagonist” means a substance that itself has a function to inhibit action on H3 receptors. The term “H4 receptor antagonist” means a substance that itself has a function to inhibit action on H4 receptors. Examples of the H1 receptor antagonists, the H3 receptor antagonists, and/or the H4 receptor antagonists include ketanserin, thonzylamine, mepyramine, tripelennamine, promethazine, dimethindene, clemastine, bamipine, isothipendyl, diphenhydramine, chlorphenoxamine, dimetotiazine, hydroxyzine, cinnarizine, levocabastine, azelastine, antazoline, olopatadine, diphenylpyraline, carbinoxamine, doxylamine, brompheniramine, dexchlorpheniramine, chlorpheniramine, pheniramine, alimemazine, mequitazine, cyclizine, meclizine, oxatomide, cetirizine, levocetirizine, cyproheptadine, phenindamine, triprolidine, azatadine, astemizole, loratadine, ketotifen, acrivastine, ebastine, epinastine, fexofenadine, desloratadine, rupatadine, bilastine, emedastine, alcaftadine, bepotastine, dimenhydrinate, dioxopromethazine, homochlorcyclizine, icotidine, mizolastine, noberastine, rocastine, tecastemizole, temelastine, irdabisant, betahistine, thioperamide, BF 2649 hydrochloride, burimamide oxalate, carcinine ditrifluoroacetate, clobenpropit dihydrobromide, conessine, GT 2016, impentamine dihydrobromide, iodophenpropit dihydrobromide, JNJ 10181457 dihydrochloride, JNJ 5207852 dihydrochloride, ROS 234 dioxalate, SEN 12333, VUF 5681 dihydrobromide, A 943931 dihydrochloride, A 987306, JNJ 10191584 maleate, JNJ 7777120, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0051]    In the present invention, any serotonin receptor ligand can be used. A serotonin receptor agonist and/or serotonin receptor antagonist can preferably be used. 
         [0052]    As used herein, the term “serotonin receptor agonist” means a substance that itself has a function to act on serotonin receptors. Examples thereof include 5-HT4 receptor agonists, 5-HT6 receptor agonists, and 5-HT7 receptor agonists. Among the serotonin receptor subtypes, 5-HT4, 5-HT6, and 5-HT7 are coupled to Gs. 
         [0053]    As used herein, the term “serotonin receptor antagonist” means a substance that itself has a function to inhibit action on serotonin receptors. Examples thereof include 5-HT1 receptor antagonists, 5-HT2 receptor antagonists, and 5-HT5 receptor antagonists. Among the serotonin receptor subtypes, 5-HT1 and 5-HT5 are coupled to Gi, and 5-HT2 is coupled to Gq. 
         [0054]    As used herein, the term “5-HT4 receptor agonist” means a substance that itself has a function to act on 5-HT4 receptors. The term “5-HT6 receptor agonist” means a substance that itself has a function to act on 5-HT6 receptors. The term “5-HT7 receptor agonist” means a substance that itself has a function to act on 5-HT7 receptors. Examples of the 5-HT4 receptor agonists, the 5-HT6 receptor agonists, and/or the 5-HT7 receptor agonists include tegaserod, prucalopride, cisapride, mosapride, naronapride, renzapride, velusetrag, zacopride, BIMU 8, benzothiazole, EMD 386088, EMDT, ST 1936, WAY 208466, AS 19, LP 12, LP 44, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0055]    As used herein, the term “5-HT1 receptor antagonist” means a substance that itself has a function to inhibit action on 5-HT1 receptors. The term “5-HT2 receptor antagonist” means a substance that itself has a function to inhibit action on 5-HT2 receptors. The term “5-HT5 receptor antagonist” means a substance that itself has a function to inhibit action on 5-HT5 receptors. Examples of the 5-HT1 receptor antagonists, the 5-HT2 receptor antagonists, and/or the 5-HT5 receptor antagonists include elzasonan, lecozotan, alprenolol, cyanopindolol, MM 77, NAD 299, NAN-190, pindolol, SDZ 21009, spiroxatrine, (S)-WAY 100135, WAY 100635, GR 127935, GR 55562, isamoltane, LY 393558, NAS-181, SB 216641, SB 224289, BRL 15572, LY 310762, dimetotiazine, levomepromazine, asenapine, chlorpromazine, ziprasidone, opipramol, mianserin, mirtazapine, cinanserin, glemanserin, metrenperone, pelanserin, setiptiline, tropanserin, ketanserin, naftidrofuryl, pizotifen, risperidone, pipamperone, sertindole, clozapine, olanzapine, quetiapine, mosapramine, zotepine, paliperidone, trazodone, nefazodone, altanserin, amesergide, blonanserin, eplivanserin, fananserin, iloperidone, lubazodone, perospirone, pimavanserin, pruvanserin, ritanserin, sarpogrelate, spiperone, temanogrel, AT 1015, dimethyltryptamine, DV 7028, EMD 281014, 4F 4PP, MDL 11, 939, melperone, mesulergine, ATC 0175, LY 266097, LY 272015, RS 127445, SB 200646, SB 204741, SB 206553, SB 221284, SB 228357, SDZ SER 082, methysergide, agomelatine, tedatioxetine, RS 102221, S 32212, SB 242084, SB 243213, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0056]    In the present invention, any PAF receptor ligand can be used. A PAF receptor antagonist can preferably be used. 
         [0057]    As used herein, the term “PAF receptor antagonist” means a substance that itself has a function to inhibit action on platelet-activating factor (PAF) receptors. Examples of the PAF receptor antagonist include apafant, israpafant, lexipafant, ginkgolide B, PCA 4248, and derivatives thereof, and pharmacologically acceptable salts thereof. The PAF receptor is coupled to Gi and Gq. 
         [0058]    In the present invention, any purine receptor ligand can be used. A purine receptor antagonist can preferably be used. 
         [0059]    As used herein, the term “purine receptor antagonist” means a substance that itself has a function to inhibit action on purine receptors. Examples thereof include P2Y12 receptor antagonists. Among the purine receptor subtypes, P2Y12 is coupled to Gi. 
         [0060]    As used herein, the term “P2Y12 receptor antagonist” means a substance that itself has a function to inhibit action on P2Y12 receptors. Examples of the P2Y12 receptor antagonists include clopidogrel, ticlopidine, prasugrel, ticagrelor, cangrelor, elinogrel, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0061]    In the present invention, any vasopressin receptor ligand can be used. A vasopressin receptor agonist and/or vasopressin receptor antagonist can preferably be used. 
         [0062]    As used herein, the term “vasopressin receptor agonist” means a substance that itself has a function to act on vasopressin receptors. Examples thereof include V2 receptor agonists. Among the vasopressin receptor subtypes, V2 is coupled to Gs. 
         [0063]    As used herein, the term “vasopressin receptor antagonist” means a substance that itself has a function to inhibit action on vasopressin receptors. Examples thereof include V1 receptor antagonists. Among the vasopressin receptor subtypes, V1 is coupled to Gq. 
         [0064]    As used herein, the term “V2 receptor agonist” means a substance that itself has a function to act on V2 receptors. Examples of the V2 receptor agonists include vasopressin, desmopressin, lypressin, terlipressin, ornipressin, argipressin, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0065]    As used herein, the term “V1 receptor antagonist” means a substance that itself has a function to inhibit action on V1 receptors. Examples of the V1 receptor antagonists include OPC 21268, SR 49059, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0066]    In the present invention, any opioid receptor ligand can be used. An opioid receptor antagonist can preferably be used. 
         [0067]    As used herein, the term “opioid receptor antagonist” means a substance that itself has a function to inhibit action on opioid receptors. Examples thereof include μ receptor antagonists, K receptor antagonists, and δ receptor antagonists. Among the opioid receptor subtypes, p, K, and 6 are coupled to Gi. 
         [0068]    As used herein, the term “p receptor antagonist” means a substance that itself has a function to inhibit action on p receptors. As used herein, the term “K receptor antagonist” means a substance that itself has a function to inhibit action on K receptors. As used herein, the term “6 receptor antagonist” means a substance that itself has a function to inhibit action on 6 receptors. Examples of the p receptor antagonists, the K receptor antagonists, and/or the 6 receptor antagonists include alvimopan, nalbuphine, naltrexone, nalorphine, naloxone, cyclazocine, eptazocine, naldemedine, quadazocine, clocinnamox, cyprodime, 3-funaltrexamine, naloxonazine, binaltorphimine, DIPPA, GNTI, ML 190, rimcazole, benzylnaltrindole, BNTX, naltriben, naltrindole, SDM25N, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0069]    In the present invention, any leukotriene receptor ligand can be used. A leukotriene receptor antagonist can preferably be used. 
         [0070]    As used herein, the term “leukotriene receptor antagonist” means a substance that itself has a function to inhibit action on leukotriene receptors. Examples thereof include BLT receptor antagonists and CysLT receptor antagonists. Among the leukotriene receptor subtypes, BLT and CysLT are coupled to Gi and Gq. 
         [0071]    As used herein, the term “BLT receptor antagonist” means a substance that itself has a function to inhibit action on BLT receptors. As used herein, the term “CysLT receptor antagonist” means a substance that itself has a function to inhibit action on CysLT receptors. Examples of the BLT receptor antagonists and/or the CysLT receptor antagonists include LY 255283, zafirlukast, pranlukast, montelukast, ablukast, pobilukast edamine, ritolukast, sulukast, tipelukast, tomelukast, verlukast, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0072]    In the present invention, any angiotensin receptor ligand can be used. An angiotensin receptor antagonist can preferably be used. 
         [0073]    As used herein, the term “angiotensin receptor antagonist” means a substance that itself has a function to inhibit action on angiotensin receptors. Examples thereof include AT1 receptor antagonists and AT2 receptor antagonists. Among the angiotensin receptor subtypes, AT1 is coupled to Gq, and AT2 is coupled to Gi. 
         [0074]    As used herein, the term “AT1 receptor antagonist” means a substance that itself has a function to inhibit action on AT1 receptors. As used herein, the term “AT2 receptor antagonist” means a substance that itself has a function to inhibit action on AT2 receptors. Examples of the AT1 receptor antagonists and/or the AT2 receptor antagonists include losartan potassium, eprosartan, valsartan, irbesartan, candesartan, telmisartan, olmesartan, azilsartan, forasartan, saralasin acetate, PD 123319, and derivatives thereof, and pharmacologically acceptable salts thereof. 
         [0075]    The vaccine pharmaceutical composition of the present invention contains at least one antigen and the composition for promoting humoral immunity induction. 
         [0076]    As used herein, the term “antigen” means any substance that can induce an immune response. Any antigen may be used. Examples thereof include infectious disease-derived antigens. 
         [0077]    As used herein, the term “infectious disease-derived antigen” means an infectious pathogen or a component thereof or any substance derived from thereof, capable of inducing an immune response (e.g., maturation of an immunocompetent cell, increase in cytokine production, promotion of antibody production). An infectious disease can be addressed (for example, treated or prevented) by administering the infectious disease-derived antigen with the composition for promoting humoral immunity induction to a subject using the pharmaceutical composition of the present invention. 
         [0078]    As used herein, the term “infectious disease” means a disease caused by infection with an infectious pathogen or multiplication of an infectious pathogen. 
         [0079]    The infectious disease is not limited. Examples thereof include virus diseases such as diseases caused by infection with adenovirus (e.g., human adenovirus), herpesvirus (e.g., herpes simplex virus, varicella-zoster virus, cytomegalovirus, human herpesvirus, Kaposi sarcoma-associated herpesvirus), picornavirus (e.g., poliovirus, common cold virus, hepatitis A virus), poxvirus (e.g., smallpox virus, vaccinia virus, molluscum contagiosum virus), picornavirus (e.g., rhinovirus, enterovirus), orthomyxovirus (e.g., influenza virus), paramyxovirus (e.g., parainfluenza virus, mumps virus, measles virus, respiratory syncytial virus (RSV), Newcastle disease virus), parvovirus (e.g., adeno associated virus), togavirus (e.g., rubella virus), coronavirus (e.g., SARS coronavirus), hepadnavirus (e.g., hepatitis B virus), flavivirus (e.g., Japanese encephalitis virus, yellow fever virus, dengue virus, West Nile fever virus, St. Louis encephalitis virus, Murray Valley encephalitis virus, hepatitis C virus, hepatitis G virus), hepevirus (e.g., hepatitis E virus), papillomavirus (e.g., human papilloma virus), calicivirus (e.g., norovirus), rhabdovirus (e.g., rabies virus, vesicular stomatitis virus), filovirus (e.g., Ebola hemorrhagic fever virus), arenavirus (e.g., Lassa virus, hepatitis D virus), bunyavirus (e.g., California encephalitis virus, Rift Valley fever virus), reovirus (e.g., rotavirus), or retrovirus (e.g., human immunodeficiency virus (HIV), adult T-cell leukemia virus); bacterial diseases such as those caused by infection with a bacterium such as  Escherichia, Enterobacter, Salmonella, Staphylococcus, Shigella, Listeria, Aerobacter, Helicobacter, Klebsiella, Proteus, Pseudomonas, Streptococcus, Chlamydia, Mycoplasma, Pneumococci, Neisseria, Clostridium, Bacillus, Corynebacterium, Mycobacterium, Campyrobacter, Vibrio, Serratia, Providencia, Chromobacterium, Brucella, Yersinia, Haemophilus , or  Bordetella ; fungous diseases such as  chlamydia , candidiasis, aspergillosis, histoplasmosis, and cryptococcal meningitis; malaria;  pneumocystis carinii  pneumonia; leishmaniasis; cryptosporidiosis; toxoplasmosis; and  Trypanosoma  infection. 
         [0080]    The amount of the Th2 reaction promoter in the composition for promoting humoral immunity induction of the present invention is not limited. The amount is preferably 0.0001 to 100% by weight, more preferably 0.001 to 80% by weight, still more preferably 0.1 to 50% by weight, most preferably 0.05 to 20% by weight based on the total weight of the composition. 
         [0081]    The amount of the antigen in the vaccine pharmaceutical composition of the present invention is not limited. The amount is preferably 0.000001 to 50% by weight, more preferably 0.00001 to 20% by weight based on the total weight of the composition. 
         [0082]    The amount of the Th2 reaction promoter in the vaccine pharmaceutical composition of the present invention is not limited. The amount is preferably 0.001 to 10000 parts by weight, more preferably 0.01 to 10000 parts by weight based on 1 part by weight of the antigen. 
         [0083]    If the amount of the Th2 reaction promoter is less than 0.001 parts by weight, the immunity inducing effect may be insufficient. If the amount is more than 10000 parts by weight, the vaccine pharmaceutical composition may cause safety issues. 
         [0084]    The composition for promoting humoral immunity induction and vaccine pharmaceutical composition of the present invention may contain additive(s), if necessary. The additives can be selected from isotonizing agents, antiseptics, antioxidants, resolvents, solubilizing agents, suspending agents, fillers, pH adjusters, stabilizers, absorption promoters, release-rate controlling agents, colorants, plasticizers, crosslinking agents, and adhesives depending on, for example, the main components of the base, the compatibility with the antigen and the composition for promoting humoral immunity induction, or intended administration regimen. These additives may be used alone or in combination of two or more thereof. 
         [0085]    The composition for promoting humoral immunity induction and vaccine pharmaceutical composition of the present invention may be intradermally, subcutaneously, or intramuscularly administered. They also may be administered to the body surface. The administration to the body surface may be transdermal administration or transmucosal administration. Accordingly, the composition for promoting humoral immunity induction and vaccine pharmaceutical composition of the present invention may be a vaccine pharmaceutical composition for intradermal, subcutaneous, or intramuscular administration, or may be a vaccine pharmaceutical composition for transdermal administration or transmucosal administration. The transdermal administration may be noninvasive or minimally invasive. 
         [0086]    Injections cause pain, fear, and injection scars with subsequent cicatrization, putting a psychological burden on patients. When repetitive administrations are required, regular hospital visits put a burden on patient life. For the QOL of patients, consideration needs to be given to these burdens. Consideration also needs to be given to the fact that injections are permitted only for health care workers, that the intradermal injection, which has high immune effects, requires difficult manipulation, that health care workers have a risk of infection via needle stick injury, and that injections generates medical waste requiring specific waste treatment, such as injection needles. In view of this, the composition for promoting humoral immunity induction and the vaccine pharmaceutical composition are preferably administered to the body surface. 
         [0087]    As used herein, the term “subject” means any animal to which the vaccine pharmaceutical composition at a practical stage can be administered so as to induce an immune response. The term typically means mammals including human, mouse, rat, canine, feline, leporine, equine, bovine, ovine, porcine, caprine, simian, and chimpanzee. The subject is particularly preferably a human. 
       &lt;Vaccine Pharmaceutical Composition for Intradermal, Subcutaneous, or Intramuscular Administration&gt; 
       [0088]    The vaccine pharmaceutical composition for intradermal, subcutaneous, or intramuscular administration of the present invention exerts a high humoral immunity inducing effect in intradermal, subcutaneous, or intramuscular administration of various antigens to the subject. In particular for immunity for prevention of infectious diseases, vaccines can be easily invasively administered to the inside of the body because the intrusion of microorganisms or viruses through the skin is usually prevented due to their size. 
         [0089]    As used herein, the term “for intradermal, subcutaneous, or intramuscular administration” in the pharmaceutical composition for intradermal, subcutaneous, or intramuscular administration refers to any form that has a certain degree of fluidity that allows administration by injection, such as a solution, a suspension, or a cream. The categories, definition, characteristics, production processes, and the like of these compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0090]    The solvent for solutions may be, for example, an appropriate amount water or saline, ethanol, glycerin, or propylene glycol. A solution can be prepared by dispersing or dissolving components into the solvent. 
         [0091]    Examples of the base usable for aqueous suspensions include hydrogel bases, such as carboxyvinyl polymers, gel bases, fat-free ointment, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, carboxymethylcellulose, starch, xanthan gum, karaya gum, sodium alginate, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), carboxymethylethylcellulose (CMEC), ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymers, tragacanth, gum arabic, tara gum, tamarind seed gum,  psyllium  seed gum, agar, gellan gum, glucomannan, locust bean gum, guar gum, carrageenan, dextrin, dextran, amylose, potassium carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, pullulan, chitosan, sodium carboxymethyl starch,  Plantago  testa, galactomannan, Eudragit, casein, alkyl alginate, gelatin, and polyethylene glycol. A fluidic suspension can be prepared by dissolving any of these bases into a solvent. The solvent is preferably saline, but glycerin or propylene glycol can also be used. 
         [0092]    Examples of the base for hydrophobic suspensions include water/oil-type bases such as hydrophilic ointment and vanishing cream; and oil/water-type bases such as hydrophilic Vaseline, purified lanolin, Aquahole, Eucerin, Neocerin, hydrous lanolin, cold cream, and hydrophilic plastibase. A fat/oil suspension can be prepared by placing any of these bases into a fat/oil solvent or water and stirring the mixture at a high speed with, for example, a homogenizer. 
       &lt;Composition for Promoting Humoral Immunity Induction for Intradermal, Subcutaneous, or Intramuscular Administration&gt; 
       [0093]    The composition for promoting humoral immunity induction for intradermal, subcutaneous, or intramuscular administration according to the present invention allows, in intradermal, subcutaneous, or intramuscular administration of various Th2 reaction promoters to the subject, more effective exertion of the humoral immunity induced by various antigens administered together with or separately from the TH2 reaction promoters. 
         [0094]    As used herein, the term “for intradermal, subcutaneous, or intramuscular administration” in the composition for promoting humoral immunity induction for intradermal, subcutaneous, or intramuscular administration refers to any form that has a certain degree of fluidity that allows administration by injection, such as a solution, a suspension, a cream. The categories, definition, characteristics, production processes, and the like of these compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0095]    For the above formulations, the same materials as those used for preparing the vaccine pharmaceutical composition for intradermal, subcutaneous, or intramuscular administration can be used. 
       &lt;Vaccine Pharmaceutical Composition for Mucosal Administration&gt; 
       [0096]    The vaccine pharmaceutical composition for mucosal administration of the present invention exerts a high humoral immunity inducing effect in mucosal administration of various antigens to the subject. 
         [0097]    As used herein, the term “for mucosal administration” in the pharmaceutical composition for mucosal administration may refer to any formulation usually used for mucosal administration, for example, sublingual, transnasal, buccal, rectal, or vaginal administration. Examples of such formulations include semisolid formulations such as gels (jellies), creams, ointments, and plasters, solutions, solid formulations such as powders, fine granules, granules, films, tablets, and orally disintegrating tablets, mucosal sprays such as aerosols, and inhalants. The categories, definition, characteristics, production processes, and the like of these compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0098]    The solvent for solutions may be, for example, an appropriate amount of water or ethanol, glycerin, or propylene glycol. A solution can be prepared by dispersing or dissolving components in the solvent. 
         [0099]    Examples of the base for gels (jellies) include hydrogel bases, such as carboxyvinyl polymers, gel bases, fat-free ointment, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, carboxymethylcellulose, starch, xanthan gum, karaya gum, sodium alginate, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), carboxymethylethylcellulose (CMEC), ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymers, tragacanth, gum arabic, tara gum, tamarind seed gum,  psyllium  seed gum, agar, gellan gum, glucomannan, locust bean gum, guar gum, carrageenan, dextrin, dextran, amylose, potassium carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, pullulan, chitosan, sodium carboxymethyl starch,  Plantago  testa, galactomannan, Eudragit, casein, alkyl alginate, gelatin, and polyethylene glycol. A fluid gel or a gel with formability can be prepared by dissolving any of these bases into a solvent. The solvent is preferably water, but glycerin or propylene glycol can also be used. 
         [0100]    Examples of the base for creams include water/oil-type bases such as hydrophilic ointment and vanishing cream; and oil/water-type bases such as hydrophilic Vaseline, purified lanolin, Aquahole, Eucerin, Neocerin, hydrous lanolin, cold cream, hydrophilic plastibase. A cream can be prepared by placing any of these bases into a fat/oil solvent or water and stirring the mixture at a high speed with, for example, a homogenizer. 
         [0101]    Examples of the base for films include polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, carboxymethylcellulose, starch, xanthan gum, karaya gum, sodium alginate, methylcellulose, carboxyvinyl polymers, agar, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), carboxymethylethylcellulose (CMEC), ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymers, tragacanth, gum arabic, locust bean gum, guar gum, carrageenan, dextrin, dextran, amylose, potassium carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, pullulan, chitosan, sodium carboxymethyl starch,  Plantago  testa, galactomannan, aminoalkyl methacrylate copolymer E, aminoalkyl methacrylate copolymer RS, methacrylic acid copolymer L, methacrylic acid copolymer LD, methacrylic acid copolymer S, methyl acrylate-methacrylic acid-methyl methacrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, polyvinyl acetal diethylamino acetate, casein, and alkyl alginate. A film can be prepared by dissolving any of these bases in a polar organic solvent such as water or ethanol, applying the solution to form a thin film, and drying the film. In one preferred embodiment, the vaccine pharmaceutical composition of the present invention for mucosal administration is in the form of a film formulation. 
         [0102]    Examples of additives for powders, fine granules, granules, and tablets include excipients such as lactose, corn starch, and crystalline cellulose, and binders such as hydroxypropylcellulose and gum arabic. Powder, fine granules, granules, and tablets can be prepared by mixing and stirring these additives with an appropriate amount of solvent such as water or ethanol and then subjecting the resulting mixture to a combination of processes such as granulation, drying, and tablet compression. If necessary, a lubricant such as magnesium stearate and a coating agent such as hydroxypropylcellulose or sucrose may be added. 
         [0103]    Examples of the base for orally disintegrating tablets (freeze dry type) include polysaccharides such as gelatin and pullulan. Forming aids such as mannitol, trehalose, sorbitol, or glycine may also be used. An orally disintegrating tablet (freeze dry type) can be prepared by dissolving these additives in water, dispensing the solution, and then freeze drying it. In one preferred embodiment, the vaccine pharmaceutical composition for mucosal administration of the present invention is in the form of an orally disintegrating tablet. 
         [0104]    The content of the aerosol may be, for example, a solution, a highly fluidic gel, a cream, or fine powder such as a powdered drug. Dispersing them as solid or liquid microparticles in a gas using a spray device enables effective administration to an administration site such as the oral mucosa or the nasal mucosa. 
       &lt;Composition for Promoting Humoral Immunity Induction for Mucosal Administration&gt; 
       [0105]    The composition for promoting humoral immunity induction for mucosal administration according to the present invention allows, in mucosal administration of various Th2 reaction promoters to the subject, more effective exertion of humoral immunity induced by various antigens administered together with or separately from the TH2 reaction promoters. 
         [0106]    As used herein, the term “for mucosal administration” in the composition for promoting humoral immunity induction for mucosal administration may refer to any formulation usually used for mucosal administration, such as sublingual, transnasal, buccal, rectal, or vaginal administration. Examples of such a formulation include semisolid formulations such as gels (jellies), creams, ointment, plasters, solutions, solid formulations such as powders, fine granules, granules, films, tablets, and orally disintegrating tablets, mucosal sprays such as aerosols, and inhalants. The categories, definition, characteristics, production processes, and the like of the compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0107]    For the above formulations, the same materials as those used for preparing the vaccine pharmaceutical composition for mucosal administration can be used. 
       &lt;Vaccine Pharmaceutical Composition for Transdermal Administration&gt; 
       [0108]    As used herein, the term “for transdermal administration” in the pharmaceutical composition for transdermal administration may refer to any formulation usually used for transdermal administration. Examples thereof include solutions for external use such as liniments and lotions, sprays for external use such as aerosols, ointments, plasters, creams, gels, and patches such as tapes or poultices. The categories, definition, characteristics, production processes, and the like of the compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0109]    Examples of the base for liniments include water, ethanol, fatty oils such as hard paraffin, soft paraffin, liquid paraffin, glycerin, paraffin oil, beeswax, or metallic soap; mucilage; natural oils [e.g., almond oil, corn oil, peanut oil, castor oil, olive oil, derivatives thereof (e.g., polyoxyl castor oil)]; mutton tallow or derivatives thereof, and fatty acids and/or esters (e.g., stearic acid, oleic acid, isopropyl myristate). 
         [0110]    Lotion is a formulation containing an active ingredient finely and homogenously dispersed in an aqueous liquid and classified into suspension lotion and emulsion lotion. The suspending agent may be, for example, gum arabic, sodium alginate, sodium carboxymethylcellulose, methylcellulose, or bentonite. The emulsifier may be, for example, sodium lauryl sulfate or sorbitan fatty acid ester. 
         [0111]    Examples of the base usable for ointments include common hydrophobic bases such as fats and oils, waxes, and hydrocarbon compounds. Specific examples include mineral bases such as yellow Vaseline, white Vaseline, paraffin, liquid paraffin, plastibase, and silicone, and animal or vegetable bases such as beeswax and animal or vegetable oils and fats. 
         [0112]    Examples of the base for creams include water/oil type bases such as hydrophilic ointment and vanishing cream; and oil/water type bases such as hydrophilic Vaseline, purified lanolin, Aquahole, Eucerin, Neocerin, hydrous lanolin, cold cream, and hydrophilic plastibase. 
         [0113]    Examples of gel bases include hydrogel bases such as carboxyvinyl polymers, gel bases, fat-free ointment, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, carboxymethylcellulose, starch, xanthan gum, karaya gum, sodium alginate, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), carboxymethylethylcellulose (CMEC), ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymer, tragacanth, gum arabic, tara gum, tamarind seed gum,  psyllium  seed gum, agar, gellan gum, glucomannan, locust bean gum, guar gum, carrageenan, dextrin, dextran, amylose, potassium carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, pullulan, chitosan, sodium carboxymethyl starch,  Plantago  testa, galactomannan, aminoalkyl methacrylate copolymer E, aminoalkyl methacrylate copolymer RS, methacrylic acid copolymer L, methacrylic acid copolymer LD, methacrylic acid copolymer S, methyl acrylate-methacrylic acid-methyl methacrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, polyvinyl acetal diethylamino acetate, casein, alkyl alginate, gelatin, and polyethylene glycol. 
         [0114]    Examples of the base for poultices include gelatin, sodium carboxymethylcellulose, methylcellulose, sodium polyacrylate, kaolin, polyvinyl alcohol, polyvinylpyrrolidone, glycerin, propylene glycol, and water. 
         [0115]    A tape includes, for example, an adhesive layer and a support for supporting the adhesive layer. The adhesive layer includes, for example, an acrylic adhesive, a natural rubber adhesive, a synthetic rubber adhesive (including rubber elastomers such as synthetic isoprene rubber, polyisobutylene (PIB), styrene-butadiene rubber, and styrene-isoprene-styrene (SIS) rubber), a silicone adhesive, a vinyl ester adhesive, or a vinyl ether adhesive. If desired, the tape may include a release liner that prevents exposure of the adhesive layer before use and can be easily peeled when the tape is used. 
         [0116]    The adhesive to constitute the adhesive layer of the tape according to the present invention is not limited. Examples thereof include acrylic adhesives containing an acrylic polymer; rubber adhesives containing a rubber elastomer such as a styrene-diene-styrene block copolymer (e.g., styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer), polyisoprene, polyisobutylene, butyl rubber, or polybutadiene; silicone adhesives such as silicone rubber, dimethyl siloxane-based adhesives, and diphenyl siloxane-based adhesives; vinyl ether adhesives such as polyvinyl methyl ether, polyvinyl ethyl ether, and polyvinyl isobutyl ether; vinyl ester adhesives such as vinyl acetate-ethylene copolymer; and polyester adhesives containing a carboxylic acid component (e.g., dimethyl terephthalate, dimethyl isophthalate, dimethyl phthalate) and a polyalcohol component (e.g., ethylene glycol). Particularly preferred adhesives are acrylic adhesives, rubber adhesives, and silicone adhesives. The adhesive layer preferably contains the adhesive(s) in an amount of 10 to 90% by weight, more preferably 20 to 80% by weight in terms of solids, based on the total weight of the adhesive layer. 
         [0117]    Examples of the acrylic adhesives include acrylate adhesives mainly composed of a polymer containing a C2-C18 alkyl (meth)acrylate as a first monomer. Examples of the alkyl (meth)acrylate (first monomer) include alkyl (meth)acrylates having a C1-C18 linear, branched, or cyclic alkyl group (e.g., methyl, ethyl, propyl, butyl, pentyl, hexyl, cyclohexyl, heptyl, octyl, 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl, tridecyl), with alkyl (meth)acrylates having a C4-C18 linear, branched, or cyclic alkyl group (e.g., butyl, pentyl, hexyl, cyclohexyl, heptyl, octyl, 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl, tridecyl) being preferred. Moreover, alkyl (meth)acrylates having a C4-C8 linear, branched, or cyclic alkyl group (e.g., butyl, pentyl, hexyl, cyclohexyl, heptyl, octyl, or 2-ethylhexyl, preferably butyl, 2-ethylhexyl, or cyclohexyl, particularly preferably 2-ethylhexyl) because the use of a monomer component that lowers the glass transition temperature of the polymer is more suitable for providing adhesiveness at normal temperature. Specifically, butyl acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, cyclohexyl acrylate, and cyclohexyl methacrylate are more preferred, and 2-ethylhexyl acrylate is most preferred. These alkyl (meth)acrylates (first monomer components) can be used alone or in combination of two or more thereof. 
         [0118]    The acrylic adhesive may contain a second monomer copolymerizable with the alkyl (meth)acrylate. Examples of the second monomer include monomers having a functional group that can be a crosslinking point when a crosslinking agent is used. Examples of such a functional group that can be involved with crosslinking reaction include a hydroxy group, a carboxy group, and a vinyl group, with a hydroxy group and a carboxy group being preferred. Specific examples of such a monomer (second monomer component) include hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, N-hydroxyalkyl(meth)acrylamide, (meth)acrylic acid, itaconic acid, maleic acid, maleic anhydride, mesaconic acid, citraconic acid, and glutaconic acid. From the viewpoint of availability, acrylic acid, methacrylic acid, and hydroxyethyl acrylate (in particular, 2-hydroxyethyl acrylate) are preferred, with acrylic acid being most preferred. These monomers (second monomer components) can be used alone or in combination of two or more thereof. 
         [0119]    The acrylic adhesive may contain a third monomer other than the second monomer, if desired. Examples of the third monomer (third monomer component) include vinyl esters such as vinyl acetate and vinyl propionate; vinyl ethers such as methyl vinyl ether and ethyl vinyl ether; vinylamides such as N-vinyl-2-pyrrolidone and N-vinylcaprolactam; alkoxy (meth)acrylates such as methoxyethyl (meth)acrylate, ethoxyethyl (meth)acrylate, and tetrahydrofurfuryl (meth)acrylate; hydroxy group-containing monomers (as the third monomer component, not as a crosslinking point) such as hydroxypropyl (meth)acrylate and α-hydroxymethyl acrylate; (meth)acrylic acid derivatives having an amide group such as (meth)acrylamide, dimethyl(meth)acrylamide, N-butyl(meth)acrylamide, and N-methylol(meth)acrylamide; aminoalkyl (meth)acrylates such as aminoethyl (meth)acrylate, dimethylaminoethyl (meth)acrylate, and t-butylaminoethyl (meth)acrylate; alkoxyalkylene glycol (meth)acrylates such as methoxyethylene glycol (meth)acrylate, methoxydiethylene glycol (meth)acrylate, methoxypolyethylene glycol (meth)acrylate, and methoxypolypropylene glycol (meth)acrylate; (meth)acrylonitrile; monomers having a sulfonic acid such as styrenesulfonic acid, allylsulfonic acid, sulfopropyl (meth)acrylate, (meth)acryloyloxynaphthalenesulfonic acid, and acrylamidemethylsulfonic acid; and vinyl group-containing monomers such as vinylpiperidone, vinylpyrimidine, vinylpiperazine, vinylpyrrole, vinylimidazole, vinyloxazole, and vinylmorpholine. Preferred among these are vinyl esters, and vinylamides. A preferred vinyl ester is vinyl acetate, and a preferred vinylamide is N-vinyl-2-pyrrolidone. These monomers (third monomer components) can be use alone or in combination of two or more thereof. 
         [0120]    When the acrylic adhesive is a copolymer of alkyl (meth)acrylate (first monomer component) and a vinyl monomer (second monomer component) having a functional group that can be involved with crosslinking reaction, the alkyl (meth)acrylate and the vinyl monomer having a functional group that can be involved with crosslinking reaction are preferably copolymerized at a weight ratio (alkyl (meth)acrylate:vinyl monomer having a functional group that can be involved with crosslinking reaction) of 99 to 85:1 to 15, more preferably 99 to 90:1 to 10. 
         [0121]    When the acrylic adhesive is a copolymer of alkyl (meth)acrylate (first monomer component), a vinyl monomer (second monomer component) having a functional group that can be involved with crosslinking reaction, and a different monomer (third monomer component), the alkyl (meth)acrylate, the vinyl monomer having a functional group that can be involved with crosslinking reaction, and the different monomer are preferably copolymerized at a weight ratio (alkyl (meth)acrylate:vinyl monomer having a functional group that can be involved with crosslinking reaction:different monomer) of 40 to 94:1 to 15:5 to 50, more preferably 50 to 89:1 to 10:10 to 40. 
         [0122]    The polymerization reaction is not limited, and may be performed by a known method per se. For example, the above monomers are reacted in the presence of a polymerization initiator (e.g., benzoyl peroxide, azobisisobutyronitrile) in a solvent (e.g., ethyl acetate) at 50° C. to 70° C. for 5 to 48 hours. 
         [0123]    Examples of particularly preferred acrylic adhesives in the present invention include 2-ethylhexyl acrylate/acrylic acid/N-vinyl-2-pyrrolidone copolymer, 2-ethylhexyl acrylate/N-(2-hydroxyethyl)acrylamide/N-vinyl-2-pyrrolidone copolymer, 2-ethylhexyl acrylate/2-hydroxyethyl acrylate/vinyl acetate copolymer, and 2-ethylhexyl acrylate/acrylic acid copolymer, with 2-ethylhexyl acrylate/acrylic acid/N-vinyl-2-pyrrolidone copolymer being more preferred. 
         [0124]    If desired, these acrylic adhesives may be subjected to physical crosslinking by radiation such as UV irradiation or electron beam irradiation, or may be subjected to chemical crosslinking using various crosslinking agents such as an isocyanate compound (e.g., trifunctional isocyanate), an organic peroxide, an organic metal salt, a metal alcoholate, a metal chelate compound, or a multifunctional compound (e.g., a multifunctional external crosslinking agent, a multifunctional monomer for internal crosslinking such as diacrylate and dimethacrylate). 
         [0125]    Examples of the rubber adhesives include those containing a rubber elastomer such as polyisobutylene-polybutene elastomer, styrene-diene-styrene block copolymer, styrene-butadiene elastomer, nitrile elastomer, chloroprene elastomer, vinylpyridine elastomer, polyisobutylene elastomer, butyl elastomer, or isoprene-isobutylene elastomer. In particular, from the viewpoint of the solubility to the antigen and the composition for promoting humoral immunity induction and the adhesiveness to the skin, preferred elastomers include polyisobutylene (PIB) and styrene-diene-styrene block copolymers [e.g., styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS)]. These elastomers may be used in combination. 
         [0126]    In order to obtain suitable adhesion and drug solubility, the rubber adhesive may contain a mixture of rubber elastomers that are the same as or different in the components and different in the average molecular weight. For polyisobutylene, for example, preferred is a mixture of a high-molecular-weight polyisobutylene with an average molecular weight 150,000 to 5,500,000, a middle-molecular-weight polyisobutylene with an average molecular weight of 10,000 to 150,000, and/or a low-molecular-weight polyisobutylene with an average molecular weight of 500 to 4,000. In the mixture, the amount of the high-molecular-weight polyisobutylene is 10 to 80% by weight, preferably 20 to 70% by weight based on the total amount of the polyisobutylenes. The amount of the middle-molecular weight polyisobutylene is 0 to 90% by weight, preferably 10 to 80% by weight based on the total amount of the polyisobutylenes. The amount of the low-molecular-weight polyisobutylene is 0 to 80% by weight, preferably 10 to 60% by weight based on the total amount of the polyisobutylenes. 
         [0127]    The average molecular weight herein means the viscosity average molecular weight calculated by Flory&#39;s viscosity equation. The average molecular weight is determined by calculating Staudinger index (J 0 ) from the flow time at 20° C. of the capillary 1 of an Ubbelohde viscometer by Schulz-Blaschke equation and calculating the viscosity average molecular weight using the J 0  value according to the formula below. 
         [0000]      ∫ 0 =η sp   /c (1+0.31 η sp )  (Schulz-Blaschke equation)
 
         [0000]      η sp   =t/t   0 −1
 
         [0000]    t: Flow time of solution (according to Hagenbach-couette correction formula)
 
t 0 : Flow time of solvent (according to Hagenbach-couette correction formula)
 
c: Concentration of solution (g/cm 3 )
 
         [0000]        J   0 =3.06×10 −2     Mv     0.65  
 
         [0000]      Mv : Viscosity average molecular weight 
         [0128]    In order to provide suitable tackiness, the rubber adhesive may contain a tackifier, such as rosin resin, polyterpene resin, coumarone-indene resin, petroleum resin, terpene-phenol resin, xylene resin, or alicyclic saturated hydrocarbon resin. The rubber adhesive can contain one or two or more of these tackifiers in an amount of 50% by weight or less, preferably 5 to 40% by weight based on the total weight of the rubber adhesive. 
         [0129]    Examples of the silicone adhesives include polyorganosiloxane adhesives, polydimethylsiloxane adhesives, and polydimethyldiphenyl-siloxane adhesives. In particular, commercially available silicone adhesives, such as BIO PSA from Dow Corning Corporation, are preferred. 
         [0130]    The support for supporting the adhesive layer is not limited. Preferably, the support is one substantially impermeable to the antigen and the composition for promoting humoral immunity induction, that is, one that prevents reduction in the amounts of the antigen, the composition for promoting humoral immunity induction, additives, and the like in the adhesive layer by not allowing them to pass through the support and escape from the back side. 
         [0131]    The support may be, for example, a single film containing polyester, polyamide, polyvinylidene chloride, polyethylene, polypropylene, polyvinyl chloride, ethylene-ethyl acrylate copolymer, polytetrafluoroethylene, ionomer resin, or metallic foil or may be a laminated film containing such films. In particular, for good adhesiveness (anchoring properties) between the support and the adhesive layer, the support is preferably a laminated film including a non-porous plastic film and a porous film each containing any of the above materials. In this case, the adhesive layer is preferably formed on the porous film-side. The porous film to be used is one that improves the anchoring properties between the adhesive layer and the porous film. Specific examples thereof include paper, woven fabrics, nonwoven fabrics, knitted fabrics, and mechanically perforated sheets. Preferred among these are paper, woven fabrics, and nonwoven fabrics from the viewpoint of the handleability. The porous film to be used is one that has a thickness within the range of 1 to 200 μm from the viewpoint of improving the anchoring properties and the flexibility and attachment operability of the tape. When the porous film is a woven fabric or a nonwoven fabric, the weight per unit area thereof is preferably 5 to 30 g/m 2 , more preferably 6 to 15 g/m 2 . 
         [0132]    Examples of the most suitable supports include a laminated film including a polyester film (preferably, polyethylene terephthalate film) with a thickness of 1.5 to 6 μm and a polyester (preferably, polyethylene terephthalate) nonwoven fabric with a weight per unit area of 6 to 15 g/m 2 . 
         [0133]    The tape according to the present invention preferably has a release liner on the adhesive side so as to protect the adhesive side until the time of use. Any release liner can be used as long as it is release-treated and can be peeled with sufficiently light force. For example, the release liner may be a film formed of polyester, polyvinyl chloride, polyvinylidene chloride, or polyethylene terephthalate, paper such as woodfree paper or glassine, or a laminated film including woodfree paper or glassine and a polyolefin, which are release-treated by applying silicone resin, fluororesin, or the like to the side to be in contact with the adhesive layer. The release liner has a thickness of preferably 10 to 200 μm, more preferably 25 to 100 μm. From the viewpoint of barrier properties and the price, the release liner is preferably formed of a polyester (in particular, polyethylene terephthalate) resin. 
         [0134]    In this case, from the viewpoint of the handleability, the thickness of the release liner is preferably about 25 to 100 μm. 
         [0135]    The pharmaceutical composition of the present invention may further include additive(s), if necessary. The additives can be selected from isotonizing agents, antiseptics, antioxidants, resolvents, solubilizing agents, suspending agents, fillers, pH adjusters, stabilizers, absorption promoters, release-rate controlling agents, colorants, plasticizers, crosslinking agents, adhesives, and the like or combinations of two or more thereof, depending on, for example, the main components of the base, the compatibility with the antigen and composition for promoting humoral immunity induction, or intended administration regimen. 
         [0136]    When the pharmaceutical composition of the present invention is in the form of a tape, the tape may contain a skin permeation enhancer as an additive. 
         [0137]    As used herein, the term “skin permeation enhancer” means a substance that can improve the efficiency at which a transdermally administered antigen permeates the skin, as compared to the efficiency obtained without the substance. Any skin permeation enhancer can be used as long as it is liquid, that is, fluidic, at room temperature (25° C.) and has an absorption promoting effect. When a mixture of two or more substances is used, the resulting mixture is liquid at room temperature (25° C.). Such an organic liquid component is preferably a hydrophobic liquid component from the viewpoint of the compatibility with the adhesive layer. 
         [0138]    Examples of the skin permeation enhancer include higher alcohols such as oleyl alcohol and octyl dodecanol; polyalcohols such as glycerin, ethyleneglycol, and polypropylene glycol; higher fatty acids such as oleic acid and caplyric acid; fatty acid esters such as isopropyl myristate, isopropyl palmitate, and ethyl oleate; polybasic acid esters such as diethyl sebacate and diisopropyl adipate; polyalcohol fatty acid esters such as diglyceryl triisostearate, sorbitan monooleate, propylene glycol dicaprylate, polyethylene glycol monolaurate, and polyoxyethyelene sorbitol tetraoleate; polyoxyethylene alkyl ether such as polyoxyethylene lauryl ether; hydrocarbons such as squalane and liquid paraffin; vegetable oils such as olive oil and castor oil; silicone oil; pyrrolidones such as N-methylpyrrolidone and N-dodecylpyrrolidone; and sulfoxides such as decylmethylsulfoxide. These can be used alone or in combination of two or more thereof. 
         [0139]    When the rubber or acrylic adhesive is used, a second skin permeation enhancer can be used. Specific examples of the second skin permeation enhancer include, but not limited to, polyvinylpyrrolidone, crospovidone, polypropylene glycol, polyvinyl alcohol, carboxyvinyl polymers, hydroxypropylcellulose, and mixtures thereof. In a preferred embodiment, the second skin permeation enhancer in the present invention contains polyvinylpyrrolidone, crospovidone and/or polypropylene glycol. 
         [0140]    In order to enhance skin permeation of the antigen, the skin permeation enhancer is preferably, for example, a higher alcohol, more specifically, a higher alcohol containing 8 to 18 (preferably 8 to 14) carbon atoms; a fatty acid ester, more specifically a fatty acid ester of a fatty acid containing 8 to 18 (preferably 12 to 16) carbon atoms with a monohydric alcohol having 1 to 18 carbon atoms; or a polyalcohol fatty acid ester. The skin permeation enhancer is particularly preferably a fatty acid ester. In particular, isopropyl myristate, isopropyl palmitate, and diethyl sebacate are preferred. The amount of the skin permeation enhancer is preferably 0.1% by weight to 70% by weight, more preferably 1% by weight to 65% by weight, still more preferably 5% by weight to 60% by weight based on the total weight of the adhesive layer. The amount of the skin permeation enhancer of 0.1% by weight or more can provide a high promoting effect for transdermal absorption. The amount of the skin permeation enhancer of 70% by weight or less is advantageous in that high transdermal absorption can be achieved while reduction in the adhesion and cohesion of the entire adhesive layer are suppressed. 
       &lt;Composition for Promoting Humoral Immunity Induction for Transdermal Administration&gt; 
       [0141]    The composition for promoting humoral immunity induction for transdermal administration according to the present invention allows, in administration of various Th2 reaction promoters to the subject, more effective exertion of humoral immunity induced by various antigens administered together with or separately from the TH2 reaction promoters. 
         [0142]    As used herein, the term “for transdermal administration” in the composition for promoting humoral immunity induction for transdermal administration may refer to any formulation usually used for transdermal administration. Examples thereof include solutions for external use such as liniments and lotions, sprays for external use such as aerosols, ointments, plasters, creams, gels, and patches such as tapes or poultices. The categories, definition, characteristics, production processes, and the like of these compositions are well known in the art. See the Japanese Pharmacopoeia 16th edition, for example. 
         [0143]    For the above formulations, the same materials as those used for preparing the vaccine pharmaceutical composition for transdermal administration can be used. 
         [0144]    As used herein, the “pharmacologically acceptable salt” that can be contained in the pharmaceutical composition of the present invention means a salt that does not adversely affect the subject and does not eliminate the pharmacological activity of the components in the pharmaceutical composition. Examples of such a salt include, but not limited to, inorganic acid salts (e.g., hydrochlorides, phosphates), organic acid salts (e.g., acetates, phthalates, TFA salts, mesylates, tartrates), metal salts (alkali metal salts (e.g., sodium salts, potassium salts), alkaline earth metal salts (e.g., calcium salts, magnesium salts), aluminum salts), amine salts (triethylamine salts, benzylamine salt, diethanolamine salts, t-butylamine salts, dicyclohexylamine salts, arginine salts, dimethylammonium salts, ammonium salts). 
       Advantageous Effects of Invention 
       [0145]    The composition for promoting humoral immunity induction and vaccine pharmaceutical composition of the present invention enable effective induction of humoral immunity by promoting Th2 reaction, the central process for antibody production. Furthermore, since the Th2 reaction promoters according to the present invention include many commercial drugs available at pharmacies and widely perceived to be highly safe, the compositions are considered to cause less adverse effects. 
         [0146]    The vaccine pharmaceutical composition of the present invention can not only be subcutaneously, intradermally, and intramuscularly injected, but also dermally and mucosally administrated. The composition thus leads to excellent compliance and offers, for example, the following advantages: The composition can be non-invasively administered (e.g., dermally or transmucosally administered), or minimally invasively administered to the skin surface (e.g., to the surface of the skin after a corneum removal treatment such as tape stripping or after a corneum perforation treatment such as a microneedle treatment or electroporation), allowing painless administration and freeing patients from fear for injections. As the composition is easy to administer, patients can administer it by themselves, which reduces the risk of infections of health care workers via needle stick injury, and also reduces the frequency of hospital visits when repetitive administrations are required, contributing to improved quality of life of patients. Moreover, medical wastes requiring specific waste treatment, such as injection needles, are not generated. The composition in a patch form such as a poultice or a tape is advantageous in that it allows secure administration of a predetermined dose and control of the drug releasing rate at any rate, and that it does not stick to unintended sites when administered. The composition in a patch form is advantageous also in that since a patch can easily be removed, patients can immediately stop the administration by themselves by removing the patch from the application site if any adverse effect occurs. The vaccine pharmaceutical composition of the present invention is also advantageous in that it has a significantly improved efficacy compared with an antigen administered alone. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0147]      FIG. 1  shows an antigen (OVA)-specific IgG antibody titer in mouse serum after transnasal administration of Th2 reaction promoter (PDE inhibitor and GPCR agonist)-containing pharmaceutical compositions. 
           [0148]      FIG. 2  shows an antigen (OVA)-specific IgG antibody titer in mouse serum after transnasal administration of Th2 reaction promoter (GPCR antagonist)-containing pharmaceutical compositions. 
           [0149]      FIG. 3  shows an antigen (OVA)-specific IgG antibody titer in mouse serum after subcutaneous administration of Th2 reaction promoter (PDE inhibitor and GPCR agonist)-containing pharmaceutical compositions. 
           [0150]      FIG. 4  shows an antigen (OVA)-specific IgG antibody titer in mouse serum after subcutaneous administration of Th2 reaction promoter (GPCR antagonist)-containing pharmaceutical compositions. 
           [0151]      FIG. 5  shows an antigen (OVA)-specific IgG antibody titer in mouse serum after transdermal administration of Th2 reaction promoter (PDE inhibitor, GPCR agonist, and GPCR antagonist)-containing pharmaceutical compositions. 
       
    
    
     DESCRIPTION OF EMBODIMENTS 
       [0152]    The present invention will be specifically described with reference to examples below. The present invention, however, is not limited to these examples. 
       Examples 1 to 30, Comparative Examples 1 to 8 
       [0153]    (Preparation of solution for transmucosal administration) A solution for transmucosal administration was prepared according to the formulation shown in Tables 2 and 3. Specifically, an antigen and a Th2 reaction promoter were blended in the amounts specified in Tables 2 and 3, and 10 uL of saline was added thereto, followed by mixing to provide a vaccine composition. 
         [0154]    Substances used are listed below. 
         [0000]    Examples: resveratrol (Wako Pure Chemical Industries, Ltd.), vinpocetine (Yodogawa Seiyaku K.K.), pimobendan (LKT Laboratories), BRL50481 (Tocris Bioscience), dipyridamole (Wako Pure Chemical Industries, Ltd.), methoxyphenamine hydrochloride (MP Biomedicals), fenoldopam mesylate (LKT Laboratories), cisapride (Sigma-Aldrich), desmopressin (Sigma-Aldrich), prazosin hydrochloride (Wako Pure Chemical Industries, Ltd.), pirenzepine hydrochloride (Wako Pure Chemical Industries, Ltd.), oxybutynin hydrochloride (LKT Laboratories), tolterodine tartrate (HELM JAPAN), fluphenazine (Sigma-Aldrich), droperidol (Sigma-Aldrich), sulpiride (Wako Pure Chemical Industries, Ltd.), azelastine hydrochloride (AdooQ BioScience), levocetirizine (Sigma-Aldrich), mequitazine (Wako Pure Chemical Industries, Ltd.), thioperamide (Sigma-Aldrich), sarpogrelate hydrochloride (Sigma-Aldrich), clopidogrel (M/s LEE Pharma), ticlopidine (Wako Pure Chemical Industries, Ltd.), prasugrel (Sigma-Aldrich), apafant (Sigma-Aldrich), naloxone (Wako Pure Chemical Industries, Ltd.), zafirlukast (Sigma-Aldrich), montelukast (LG Life Sciences), pranlukast (Cayman Chemical), candesartan (AdooQ BioScience) Comparative Examples: propranolol hydrochloride (Sigma-Aldrich), butaclamol hydrochloride (Sigma-Aldrich), piboserod hydrochloride (Axon Medchem), tolvaptan (Sigma-Aldrich), metaraminol (Sigma-Aldrich), cevimeline (Sigma-Aldrich), cabergoline (Toronto Research Chemicals)
 
Model antigen: ovalbumin (OVA)
 
       (Mouse Immunity Test of Solution for Transmucosal Administration) 
       [0155]    A mouse immunity test using an animal model for immunity evaluation was performed with the solution prepared as described above. A Mouse (BALB/c mouse, female, 7 weeks old) was provided in advance. After the mouse was anesthetized, the solution was administered to the mouse by transnasal administration (10 uL) or sublingual administration (30 uL). One week after the administration, the mouse was anesthetized again, and the solution was administered again in the same manner. 
         [0156]    One week after the second administration, the mouse serum and nasal wash were taken, and the OVA-specific IgG antibody titer in the serum was determined by ELISA. 
       ELISA 
       [0157]    The systemic immune response was evaluated by determining the OVA-specific IgG antibody titer in the mouse serum. 
       &lt;Method for Determining Antigen-Specific IgG Antibody Titer in Mouse Serum (ELISA)&gt; 
       [0158]    To each well of a 96-well plate for ELISA was added 100 uL of an OVA-containing solution (100 ug/mL) diluted with carbonate buffer, followed by standing overnight. 
         [0159]    The wells were washed three times with preliminarily prepared wash (Tween 20-containing PBS), and to each well was added 200 uL of a blocking solution prepared by diluting a blocking agent (Block Ace, Sumitomo Dainippon Pharma Co., Ltd.) in purified water to 4 g/100 mL. This was followed by standing for 2 hours at room temperature. The wells were then washed three times with wash. 
         [0160]    The serum taken from the mouse was centrifuged at 4° C. and 3000 g for 10 minutes, and the supernatant was recovered. The supernatant or nasal wash was diluted in two-fold increments using a solution prepared by diluting a blocking agent in a phosphate buffer (Nacalai Tesque, Inc.) to 0.4 g/100 mL. The diluted solution was added to wells (50 μL for each well), followed by standing for 2 hours at room temperature. 
         [0161]    The wells were then washed three times with wash. An HRP-labeled anti-mouse IgG antibody (Goat-anti mouse IgG Fc HRP, BETHYL) was diluted 10000-fold using a solution prepared by diluting a blocking agent in a phosphate buffer (Nacalai Tesque, Inc.) to 0.4 g/100 mL. To each well was added 100 uL of the resulting solution, followed by standing for 1 hour at room temperature. 
         [0162]    The wells were then washed three times with wash, and 100 uL of a TMB solution (ELISA POD TMB kit, Nacalai Tesque, Inc.) was added to each well, followed by standing for 30 minutes at dark place. 
         [0163]    Thereafter, 100 uL of a 1M sulfuric acid solution was added to each well, and the 96-well plate was subjected to measurement of absorbance at 450 nm with a microplate reader (Spectra Max M2 e , molecular device). The IgG antibody titer in the mouse serum was determined as Log 2 titer based on the absorbance at the incremental dilution. The results are shown in  FIGS. 1 and 2 . 
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 2 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
                 IgG anti- 
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 body titer 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 [ug] 
                 Name 
                 [ug] 
                 effect 
                 [Log2 titer] 
               
               
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 — 
                 — 
                 — 
                 5.4 
               
               
                 Ex. 1 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Propranolol 
                 20 
                 β1-3 
                 5.1 
               
               
                 Ex. 2 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Butaclamol 
                 20 
                 D1 
                 5.3 
               
               
                 Ex. 3 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Piboserod 
                 20 
                 5-HT4 
                 5.4 
               
               
                 Ex. 4 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Tolvaptan 
                 40 
                 V2 
                 5.5 
               
               
                 Ex. 5 
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 1 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Resveratrol 
                 40 
                 PDE 
                 10.8 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 2 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Vinpocetine 
                 20 
                 PDE 
                 10.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 3 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Pimobendan 
                 20 
                 PDE 
                 10.8 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 4 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 BRL50481 
                 20 
                 PDE 
                 9.4 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 5 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Dipyridamole 
                 40 
                 PDE 
                 12.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 6 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Methoxyphenamine 
                 20 
                 β2 
                 11.6 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 7 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Fenoldopam 
                 20 
                 D1 
                 11.8 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 8 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Cisapride 
                 20 
                 5-HT4 
                 9.9 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 9 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Desmopressin 
                 20 
                 V2 
                 11.3 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 3 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
                 IgG anti- 
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 body titer 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 [ug] 
                 Name 
                 [ug] 
                 effect 
                 [Log2 titer] 
               
               
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Metaraminol 
                 20 
                 α1,2 
                 4.6 
               
               
                 Ex. 6 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Cevimeline 
                 20 
                 M1,3 
                 4.6 
               
               
                 Ex. 7 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Cabergoline 
                 20 
                 D2 
                 5.0 
               
               
                 Ex. 8 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 10 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Prazosin 
                 80 
                 α1,2 
                 11.3 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 11 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Pirenzepine 
                 20 
                 M1 
                 10.8 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 12 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Oxybutynin 
                 40 
                 M2 
                 12.6 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 13 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Tolterodine 
                 80 
                 M3 
                 11.9 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 14 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Fluphenazine 
                 10 
                 D2 
                 12.6 
               
               
                 Ex. 15 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Droperidol 
                 20 
                 antagonization 
                 10.5 
               
               
                 Ex. 16 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Sulpiride 
                 20 
                   
                 11.3 
               
               
                 Ex. 17 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Azelastine 
                 40 
                 H1 
                 11.3 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 18 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Levocetirizine 
                 20 
                   
                 12.3 
               
               
                 Ex. 19 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Mequitazine 
                 20 
                   
                 10.0 
               
               
                 Ex. 20 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Thioperamide 
                 20 
                 H3 
                 10.5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 21 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10.0 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 22 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Clopidogrel 
                 20 
                 P2Y12 
                 13.4 
               
               
                 Ex. 23 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Ticlopidine 
                 40 
                 antagonization 
                 11.6 
               
               
                 Ex. 24 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Prasugrel 
                 20 
                   
                 11.6 
               
               
                 Ex. 25 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Apafant 
                 20 
                 PAF 
                 11.0 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 26 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10.0 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 27 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Zafirlukast 
                 20 
                 CysLT 
                 10.1 
               
               
                 Ex. 28 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Montelukast 
                 20 
                 antagonization 
                 10.4 
               
               
                 Ex. 29 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Pranlukast 
                 20 
                   
                 11.6 
               
               
                 Ex. 30 
                 Transnasal 
                 Solution 
                 OVA 
                 1 
                 Candesartan 
                 20 
                 AT1 
                 9.3 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
       Examples 31 to 55, Comparative Examples 9 to 16 
     (Preparation of Injection for Subcutaneous Administration) 
       [0164]    An injection for subcutaneous administration was prepared according to the formulation shown in Table 4 and 5 below. Specifically, an antigen and a Th2 reaction promoter were blended in the amounts shown in Tables 4 and 5, and 100 uL of saline was added thereto, followed by mixing to provide a vaccine composition. 
         [0165]    Substances used are listed below. 
         [0000]    Example: resveratrol (Wako Pure Chemical Industries, Ltd.), EHNA (Wako Pure Chemical Industries, Ltd.), cilostazol (LKT Laboratories), pimobendan (LKT Laboratories), BRL50481 (Tocris Bioscience), dipyridamole (Wako Pure Chemical Industries, Ltd.), methoxyphenamine hydrochloride (MP Biomedicals), fenoldopam mesylate (LKT Laboratories), cisapride (Sigma-Aldrich), desmopressin (Sigma-Aldrich), prazosin hydrochloride (Wako Pure Chemical Industries, Ltd.), pirenzepine hydrochloride (Wako Pure Chemical Industries, Ltd.), tolterodine tartrate (HELM JAPAN), scopolamine (Wako Pure Chemical Industries, Ltd.), perphenazine (Sigma-Aldrich), droperidol (Sigma-Aldrich), sulpiride (Wako Pure Chemical Industries, Ltd.), azelastine hydrochloride (AdooQ BioScience), thioperamide (Sigma-Aldrich), sarpogrelate hydrochloride (Sigma-Aldrich), clopidogrel (M/s LEE Pharma), ticlopidine (Wako Pure Chemical Industries, Ltd.), prasugrel (Sigma-Aldrich), apafant (Sigma-Aldrich), naloxone (Wako Pure Chemical Industries, Ltd.), montelukast (LG Life Sciences), candesartan (AdooQ BioScience)
 
Comparative Example: propranolol hydrochloride (Sigma-Aldrich), butaclamol hydrochloride (Sigma-Aldrich), piboserod hydrochloride (Axon Medchem), tolvaptan (Sigma-Aldrich), metaraminol (Sigma-Aldrich), cevimeline (Sigma-Aldrich), cabergoline (Toronto Research Chemicals)
 
Model antigen: ovalbumin (OVA)
 
       (Mouse Immunity Test of Injection for Subcutaneous Administration) 
       [0166]    A mouse immunity test using an animal model for immunity evaluation was performed with the solution prepared as described above. A mouse (BALB/c mouse, female, 7 weeks old) was provided in advance, and 200 uL of the injection was subcutaneously injected to the back of the mouse. One week after the administration, the injection was administered again in the same manner. 
         [0167]    One week after the second administration, the mouse serum was taken, and the OVA-specific IgG antibody titer in the serum was determined by ELISA. The results are shown in  FIGS. 3 and 4 . 
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 4 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
                 IgG anti- 
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 body titer 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 [ug] 
                 Name 
                 [ug] 
                 effect 
                 [Log2 titer] 
               
               
                   
               
             
          
           
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 — 
                 — 
                 — 
                 6.5 
               
               
                 Ex. 9 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Propranolol 
                 200 
                 β1-3 
                 5.5 
               
               
                 Ex. 10 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Butaclamol 
                 200 
                 D1 
                 5.8 
               
               
                 Ex. 11 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Piboserod 
                 200 
                 5-HT4 
                 5.9 
               
               
                 Ex. 12 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Tolvaptan 
                 200 
                 V2 
                 5.4 
               
               
                 Ex. 13 
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 31 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Resveratrol 
                 200 
                 PDE 
                 12.4 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 32 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 EHNA 
                 200 
                 PDE 
                 11.3 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 33 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Cilostazol 
                 200 
                 PDE 
                 10.6 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 34 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Pimobendan 
                 200 
                 PDE 
                 10.0 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 35 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 BRL50481 
                 200 
                 PDE 
                 11.0 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 36 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Dipyridamole 
                 200 
                 PDE 
                 12.5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 37 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Methoxyphenamine 
                 200 
                 β2 
                 9.6 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 38 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Fenoldopam 
                 200 
                 D1 
                 10.3 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 39 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Cisapride 
                 200 
                 5-HT4 
                 10.8 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 40 
                 Subcutaneous 
                 Solution 
                 OVA 
                 0.05 
                 Desmopressin 
                 200 
                 V2 
                 9.9 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 5 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
                 IgG anti- 
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 body titer 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 [ug] 
                 Name 
                 [ug] 
                 effect 
                 [Log2 titer] 
               
               
                   
               
             
          
           
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Metaraminol 
                 200 
                 α1,2 
                 5.1 
               
               
                 Ex. 14 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Cevimeline 
                 200 
                 M1,3 
                 5.5 
               
               
                 Ex. 15 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Cabergoline 
                 200 
                 D2 
                 5.6 
               
               
                 Ex. 16 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 41 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Prazosin 
                 200 
                 α1,2 
                 13.9 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 42 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Pirenzepine 
                 200 
                 M1 
                 10.8 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 43 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Tolterodine 
                 200 
                 M3 
                 11.6 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 44 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Scopolamine 
                 200 
                 M1-5 
                 10.6 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 45 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Perphenazine 
                 200 
                 D2 block 
                 10.9 
               
               
                 Ex. 46 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Droperidol 
                 200 
                   
                 10.9 
               
               
                 Ex. 47 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Sulpiride 
                 200 
                   
                 10.0 
               
               
                 Ex. 48 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Azelastine 
                 200 
                 H1 
                 10.3 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 49 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Clopidogrel 
                 200 
                 P2Y12 
                 9.8 
               
               
                 Ex. 50 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Ticlopidine 
                 200 
                 antagonization 
                 10.5 
               
               
                 Ex. 51 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Prasugrel 
                 200 
                   
                 10.8 
               
               
                 Ex. 52 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Apafant 
                 200 
                 PAF 
                 10.8 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonizstion 
               
               
                 Ex. 53 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Naloxone 
                 200 
                 μ, κ, σ 
                 9.5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 54 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Montelukast 
                 200 
                 CysLT1 
                 10.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 55 
                 Subcutaneous 
                 Solution 
                 OVA 
                 1 
                 Candesartan 
                 200 
                 AT1 
                 11.5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
       Examples 56 to 69, Comparative Examples 17 to 23 
     (Preparation of Cream for Transdermal Administration) 
       [0168]    A cream for transdermal administration was prepared according to the formulation shown in Table 6 below. Specifically, an antigen and a Th2 reaction promoter were blended in the amounts shown in Table 6. To the mixture was added a base (base cream) to achieve a total amount of 100 parts by weight, followed by mixing to provide a cream. The base cream was prepared by blending and mixing the materials according to the formulation shown in Table 48. 
         [0169]    A composite base was prepared by bonding a PET film/PET nonwoven fabric laminate (area: 0.7 cm 2 ) to the center portion of an adhesive tape for attachment such that the PET film side faced the adhesive side of the tape. The cream in an amount of 4 mg was applied to the nonwoven fabric portion of the composite base to provide a sample for an immunity test. 
         [0170]    Substances used are listed below. 
         [0000]    Example: resveratrol (Wako Pure Chemical Industries, Ltd.), dipyridamole (Wako Pure Chemical Industries, Ltd.), methoxyphenamine hydrochloride (MP Biomedicals), fenoldopam mesylate (LKT Laboratories), cisapride (Sigma-Aldrich), prazosin hydrochloride (Wako Pure Chemical Industries, Ltd.), oxybutynin hydrochloride (LKT Laboratories), tolterodine tartrate (HELM JAPAN), perphenazine (Sigma-Aldrich), azelastine hydrochloride (AdooQ BioScience), clopidogrel (M/s LEE Pharma), apafant (Sigma-Aldrich), montelukast (LG Life Sciences), candesartan (AdooQ BioScience) Comparative Example: propranolol hydrochloride (Sigma-Aldrich), butaclamol hydrochloride (Sigma-Aldrich), piboserod hydrochloride (Axon Medchem), metaraminol (Sigma-Aldrich), cevimeline (Sigma-Aldrich), cabergoline (Toronto Research Chemicals)
 
Model antigen: ovalbumin (OVA)
 
       (Mouse Immunity Test of Cream for Transdermal Administration) 
       [0171]    A mouse immunity test using an animal model for immunity evaluation was performed with the cream prepared as described above. The right back of a mouse (C57BL6 NCr mice, female, 7 weeks old) was shaved in advance. After a rearing period for recovery from the skin damage caused by the shaving, 4 mg of the cream was administered to the skin of the right back of the mouse, and the left back was shaved at the same time. Twenty-four hours later, the formulation was removed. One week after the administration, the cream was administered to the skin of the left back of the mouse, and removed 24 hours later. 
         [0172]    One week after the second administration, the mouse serum was taken and the OVA-specific IgG antibody titer in the serum was determined by ELISA. The results are shown in  FIG. 5 . 
         [0173]    White Vaseline, sorbitan monostearate, isostearic acid, benzyl alcohol, stearyl alcohol, polysorbate 60, and concentrated glycerin were purchased from Wako Pure Chemical Industries, Ltd. Cetanol was purchased from Tokyo Chemical Industry Co., Ltd. 
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 6 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                   
                   
                   
                 Amount 
                   
                 Amount 
                   
                 IgG anti- 
               
               
                   
                 Administration 
                 Dosage 
                   
                 [Parts 
                   
                 [Parts 
                 Pharmacological 
                 body titer 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 by weight] 
                 Name 
                 by weight] 
                 effect 
                 [Log2 titer] 
               
               
                   
               
             
          
           
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 — 
                 — 
                 — 
                 5.3 
               
               
                 Ex. 17 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Propranolol 
                 5.0 
                 β1-3 
                 5.0 
               
               
                 Ex. 18 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Butaclamol 
                 5.0 
                 D1 
                 5.0 
               
               
                 Ex. 19 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Piboserod 
                 5.0 
                 5-HT4 
                 5.3 
               
               
                 Ex. 20 
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Metaraminol 
                 5.0 
                 α1,2 
                 5.1 
               
               
                 Ex. 21 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Cevimeline 
                 5.0 
                 M1,3 
                 5.0 
               
               
                 Ex. 22 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Cabergoline 
                 5.0 
                 D2 
                 5.0 
               
               
                 Ex. 23 
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 56 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Resveratrol 
                 5.0 
                 PDE 
                 10.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 57 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Dipyridamole 
                 5.0 
                 PDE 
                 9.9 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 58 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Methoxyphenamine 
                 5.0 
                 β2 
                 9.6 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 59 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Fenoldopam 
                 5.0 
                 D1 
                 10.0 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 60 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Cisapride 
                 5.0 
                 5-HT4 
                 9.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 61 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Prazosin 
                 5.0 
                 α1,2 
                 10.9 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 62 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Oxybutynin 
                 5.0 
                 M2 
                 10.5 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 63 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Tolterodine 
                 5.0 
                 M3 
                 10.9 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 64 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Perphenazine 
                 5.0 
                 D2 block 
                 8.9 
               
               
                 Ex. 65 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Azelastine 
                 5.0 
                 H1 
                 9.1 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 66 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Clopidogrel 
                 5.0 
                 P2Y12 
                 10.3 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 67 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Apafant 
                 5.0 
                 PAF 
                 10.1 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 68 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Montelukast 
                 5.0 
                 CysLT1 
                 10.9 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 69 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Candesartan 
                 5.0 
                 AT1 
                 8.4 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
       Examples 70 to 83, Comparative Example 24 
     (Preparation of Cream for Transdermal (Minimally Invasive) Administration) 
       [0174]    A cream for transdermal administration according to the formulation shown in Table 7 below was prepared in the same manner as the cream for transdermal administration shown in Table 6. The right back of a mouse (C57BL6 NCr mouse, female, 7 weeks old) was shaved, and after the skin was subjected to a corneum removing treatment five times with an OPP tape (EZ Dunplon No. 3301EZ, Nitto Denko Corporation), the cream was administered to the skin (minimally invasive administration), and the left back was shaved at the same time. Twenty-four hours later, the cream for transdermal administration on the right back was removed. One week after the administration, the skin of the left back of the mouse was subjected to a corneum removing treatment in the same manner as above, and the cream for transdermal administration was administered thereto. The cream was removed 24 hours later. One week after the second administration, the mouse serum was taken, and the antigen (OVA)-specific IgG antibody in the serum was determined by ELISA. Also in this immunization using the minimally invasive administration, humoral immunity specific to the administered antigen can be induced. 
         [0175]    Substances used are listed below. 
         [0000]    Example: resveratrol (Wako Pure Chemical Industries, Ltd.), dipyridamole (Wako Pure Chemical Industries, Ltd.), methoxyphenamine hydrochloride (MP Biomedicals), fenoldopam mesylate (LKT Laboratories), cisapride (Sigma-Aldrich), prazosin hydrochloride (Wako Pure Chemical Industries, Ltd.), oxybutynin hydrochloride (LKT Laboratories), tolterodine tartrate (HELM JAPAN), perphenazine (Sigma-Aldrich), azelastine hydrochloride (AdooQ BioScience), clopidogrel (M/s LEE Pharma), apafant (Sigma-Aldrich), montelukast (LG Life Sciences), candesartan (AdooQ BioScience)
 
Model antigen: ovalbumin (OVA)
 
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 7 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                   
                   
                   
                 Amount 
                   
                 Amount 
                   
               
               
                   
                 Administration 
                 Dosage 
                   
                 [Parts by 
                   
                 [Parts by 
                 Pharmacological 
               
               
                 No. 
                 route 
                 form 
                 Name 
                 weight] 
                 Name 
                 weight] 
                 effect 
               
               
                   
               
               
                 Comp. 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 — 
                 — 
                   
               
               
                 Ex. 24 
                 (minimally invasive) 
               
               
                 Ex. 70 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Resveratrol 
                 5.0 
                 PDE 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 71 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Dipyridamole 
                 5.0 
                 PDE 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 72 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Methoxyphenamine 
                 5.0 
                 β2 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 73 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Fenoldopam 
                 5.0 
                 D1 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 74 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Cisapride 
                 5.0 
                 5-HT4 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 75 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Prazosin 
                 5.0 
                 α1,2 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 76 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Oxybutynin 
                 5.0 
                 M2 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 77 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Tolterodine 
                 5.0 
                 M3 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 78 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Perphenazine 
                 5.0 
                 D2 block 
               
               
                   
                 (minimally invasive) 
               
               
                 Ex. 79 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Azelastine 
                 5.0 
                 H1 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 80 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Clopidogrel 
                 5.0 
                 P2Y12 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 81 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Apafant 
                 5.0 
                 PAF 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 82 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Montelukast 
                 5.0 
                 CysLT 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 83 
                 Transdermal 
                 Cream 
                 OVA 
                 5.0 
                 Candesartan 
                 5.0 
                 AT1 
               
               
                   
                 (minimally invasive) 
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
       Example 84 to 1283, Comparative Examples 25 to 64 
     (Preparation of Solution for Transmucosal Administration) 
       [0176]    A solution for transmucosal administration (transnasal administration or sublingual administration) was prepared according to the formulation shown in Tables 8 to 47 below. Specifically, an antigen and Th2 reaction promoter were blended in the amounts shown in Tables 8 to 47. For transnasal administration, saline was added so that the amount of the resulting mixture was 10 μL. For sublingual administration, saline was added so that the amount of the resulting mixture was 30 μL. This was followed by mixing to provide a solution for transmucosal administration (transnasal administration or sublingual administration). 
       Model Antigens in Tables 8 to 47 
       [0177]    As influenza vaccine antigens, an influenza vaccine antigen-containing solution H1N1 (A/California/07/2009, The Research Foundation for Microbial Diseases of Osaka University), H3N2 (A/Victoria361/2011, The Research Foundation for Microbial Diseases of Osaka University), Influenza B virus (B/Wisconsin/1/2010, The Research Foundation for Microbial Diseases of Osaka University), Influenza B virus (B/Brisbane/60/2008, The Research Foundation for Microbial Diseases of Osaka University) were used. Also used were a pneumococcal capsular polysaccharide-containing solution (Pneumovax NP, MSD), HPV16 recombinant protein-containing solution (HPV16, PROSPEC), a live attenuated rotavirus-containing solution (RotaTeq Oral Solution, MSD), an inactivated poliovirus-containing solution (IMOVAX POLIO for subcutaneous injection, Sanofi), an inactivated hepatitis A virus-containing solution (Aimmugen, The Chemo-Sero-Therapeutic Research Institute), an inactivated Japanese encephalitis virus-containing solution (Encevac for subcutaneous injection, The Chemo-Sero-Therapeutic Research Institute), a live attenuated mumps virus-containing solution (live mumps vaccine, Kitasato Daiichi Sankyo Vaccine Co., Ltd), a live attenuated measles virus-containing solution (live measles vaccine, Kitasato Daiichi Sankyo Vaccine Co., Ltd), a live attenuated rubella virus-containing solution (dried live attenuated rubella vaccine, Kitasato Daiichi Sankyo Vaccine Co., Ltd), a solution containing tetanus toxoid-conjugated  haemophilus influenzae  type b polysaccharide (ActHIB, Sanofi), a recombinant HBs antigen protein-containing solution (Bimmugen, The Chemo-Sero-Therapeutic Research Institute), a live attenuated yellow fever virus-containing solution (yellow fever vaccine, Sanofi), a tetanus toxoid-containing solution (tetanus toxoid, Denka Seiken Co., Ltd.), a live attenuated varicella virus-containing solution (dried live attenuated varicella vaccine, The Research Foundation for Microbial Diseases of Osaka University), a live BCG-containing solution (dried BCG vaccine, Japan BCG Laboratory), and an inactivated rabies virus-containing solution (tissue-cultured inactivated rabies vaccine, The Chemo-Sero-Therapeutic Research Institute). 
         [0178]    Substances shown in Tables 8 to 47 are listed below. 
         [0000]    Example: resveratrol (Wako Pure Chemical Industries, Ltd.), vinpocetine (Yodogawa Seiyaku K.K.), pimobendan (LKT Laboratories), BRL50481 (Tocris Bioscience), dipyridamole (Wako Pure Chemical Industries, Ltd.), methoxyphenamine hydrochloride (MP Biomedicals), fenoldopam mesylate (LKT Laboratories), cisapride (Sigma-Aldrich), desmopressin (Sigma-Aldrich), prazosin hydrochloride (Wako Pure Chemical Industries, Ltd.), pirenzepine hydrochloride (Wako Pure Chemical Industries, Ltd.), oxybutynin hydrochloride (LKT Laboratories), tolterodine tartrate (HELM JAPAN), fluphenazine (Sigma-Aldrich), droperidol (Sigma-Aldrich), sulpiride (Wako Pure Chemical Industries, Ltd.), azelastine hydrochloride (AdooQ BioScience), levocetirizine (Sigma-Aldrich), mequitazine (Wako Pure Chemical Industries, Ltd.), thioperamide (Sigma-Aldrich), sarpogrelate hydrochloride (Sigma-Aldrich), clopidogrel (M/s LEE Pharma), ticlopidine (Wako Pure Chemical Industries, Ltd.), prasugrel (Sigma-Aldrich), apafant (Sigma-Aldrich), naloxone (Wako Pure Chemical Industries, Ltd.), zafirlukast (Sigma-Aldrich), montelukast (LG Life Sciences), pranlukast (Cayman Chemical), candesartan (AdooQ BioScience) 
         [0179]    A mouse immunity test using an animal model for immunity evaluation was performed with the solution prepared as described above. A mouse was provided in advance. After the mouse was anesthetized, the solution was administered to the mouse by transnasal administration (10 uL) or sublingual administration (30 uL). One week after the administration, the mouse was anesthetized again, and the solution was administered again in the same manner. One week after the second administration, the mouse serum and nasal wash were taken, and the OVA-specific IgG antibody titer in the serum was determined by ELISA. In the immunization by transmucosal administration (transnasal administration and sublingual administration), humoral immunity specific to the administered antigen can be induced. 
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 8 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 25 
                   
                   
                 [H1N1] 
               
               
                 Ex. 84 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 85 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 86 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 87 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 88 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 89 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 90 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 91 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 activation 
               
               
                 Ex. 92 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 activation 
               
               
                 Ex. 93 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 94 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 95 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 96 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 97 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 98 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 99 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 100 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 101 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 102 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 103 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 104 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 105 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 106 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 107 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 108 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 109 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 110 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 111 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 112 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 113 
                 Transnasal 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 9 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 26 
                   
                   
                 [H1N1] 
               
               
                 Ex. 114 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 115 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 116 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 117 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 118 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 119 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 120 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 121 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 activation 
               
               
                 Ex. 122 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 activation 
               
               
                 Ex. 123 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 124 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 125 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 126 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 127 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 128 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 129 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 130 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 131 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 132 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 133 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 134 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 135 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 136 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 137 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 138 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 139 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 140 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 141 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 142 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H1N1] 
               
               
                 Ex. 143 
                 Sublingual 
                 Solution 
                 A/California/07/2009 
                 1.0 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 [H1N1] 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 10 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 27 
                   
                   
                 [H3N2] 
               
               
                 Ex. 144 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 145 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 146 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 147 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 148 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 149 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 150 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 151 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 activation 
               
               
                 Ex. 152 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 activation 
               
               
                 Ex. 153 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 154 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 155 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 156 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 157 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 158 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 159 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 160 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 161 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 162 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 163 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 164 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 165 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 166 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 167 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 168 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 169 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 170 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 171 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 172 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 173 
                 Transnasal 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 11 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 28 
                   
                   
                 [H3N2] 
               
               
                 Ex. 174 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 175 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 176 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 177 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 178 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 179 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 180 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 181 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 activation 
               
               
                 Ex. 182 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 activation 
               
               
                 Ex. 183 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 184 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 185 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 186 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 187 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 188 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 189 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 190 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 191 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 192 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 193 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 194 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 195 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 196 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 197 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 198 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 199 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 200 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 201 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 202 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 [H3N2] 
               
               
                 Ex. 203 
                 Sublingual 
                 Solution 
                 A/Victoria361/2011 
                 1.0 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 [H3N2] 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 12 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 29 
               
               
                 Ex. 204 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 205 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 206 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 207 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 208 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 209 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 210 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 211 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 212 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 213 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 214 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                   
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 215 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 216 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 217 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 218 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Droperidol 
                 20 
                   
                 10 
               
               
                 Ex. 219 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                 Ex. 220 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 221 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                 Ex. 222 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                 Ex. 223 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 224 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 225 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 226 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                 Ex. 227 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                 Ex. 228 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 229 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 230 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 231 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Montelukast 
                 20 
                   
                 10 
               
               
                 Ex. 232 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                 Ex. 233 
                 Transnasal 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 13 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 30 
               
               
                 Ex. 234 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 235 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 236 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 237 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 238 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 239 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 240 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 241 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 242 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 243 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 244 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                   
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 245 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 246 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 247 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 248 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Droperidol 
                 100 
                   
                 30 
               
               
                 Ex. 249 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                 Ex. 250 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 251 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                 Ex. 252 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                 Ex. 253 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 254 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 255 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 256 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                 Ex. 257 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                 Ex. 258 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 259 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 260 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 261 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Montelukast 
                 100 
                   
                 30 
               
               
                 Ex. 262 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                 Ex. 263 
                 Sublingual 
                 Solution 
                 B/Wisconsin/1/2010 
                 1.0 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 14 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 31 
               
               
                 Ex. 264 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 265 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 266 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 267 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 268 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 269 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 270 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 271 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 272 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 273 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 274 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                   
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 275 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 276 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 277 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 278 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Droperidol 
                 20 
                   
                 10 
               
               
                 Ex. 279 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                 Ex. 280 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 281 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                 Ex. 282 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                 Ex. 283 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 284 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 285 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 286 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                 Ex. 287 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                 Ex. 288 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 289 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 290 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 291 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Montelukast 
                 20 
                   
                 10 
               
               
                 Ex. 292 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                 Ex. 293 
                 Transnasal 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 15 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 32 
               
               
                 Ex. 294 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 295 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 296 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 297 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 298 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 inhibition 
               
               
                 Ex. 299 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 300 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                   
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 301 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 302 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 activation 
               
               
                 Ex. 303 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 304 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                   
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 305 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 306 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                   
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 307 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 308 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Droperidol 
                 100 
                   
                 30 
               
               
                 Ex. 309 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                 Ex. 310 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 311 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                 Ex. 312 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                 Ex. 313 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 314 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                   
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 315 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 316 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                 Ex. 317 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                 Ex. 318 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 319 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 320 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                 Ex. 321 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Montelukast 
                 100 
                   
                 30 
               
               
                 Ex. 322 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                 Ex. 323 
                 Sublingual 
                 Solution 
                 B/Brisbane/60/2008 
                 1.0 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                   
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 16 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 33 
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 324 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 325 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 326 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 327 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 328 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 329 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 330 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 331 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 activation 
               
               
                 Ex. 332 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 activation 
               
               
                 Ex. 333 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 334 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 335 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 336 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 337 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 338 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 339 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 340 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 341 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 342 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 343 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 344 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 345 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 346 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 347 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 348 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 349 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 350 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 351 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 352 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 353 
                 Transnasal 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 17 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 34 
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 354 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 355 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 356 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 357 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 358 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 359 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 360 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 361 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 activation 
               
               
                 Ex. 362 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 activation 
               
               
                 Ex. 363 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 364 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 365 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 366 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 367 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 368 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 369 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 370 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 371 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 372 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 373 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 374 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 375 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 376 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 377 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 378 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 379 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 380 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 381 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 382 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
               
               
                 Ex. 383 
                 Sublingual 
                 Solution 
                 Pneumococcal capsular polysaccharide 
                 20 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 Pneumovax NP 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 18 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 35 
                   
                   
                 recombinant protein 
               
               
                 Ex. 384 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 385 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 386 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 387 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 388 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 389 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 390 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 391 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 activation 
               
               
                 Ex. 392 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 activation 
               
               
                 Ex. 393 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 394 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 395 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 396 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 397 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 398 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 399 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 400 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 401 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 402 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 403 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 404 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 405 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 406 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 407 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 408 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 409 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 410 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 411 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 412 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 413 
                 Transnasal 
                 Solution 
                 HPV16 
                 10 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 19 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 36 
                   
                   
                 recombinant protein 
               
               
                 Ex. 414 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 415 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 416 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 417 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 418 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 419 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 420 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 421 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 activation 
               
               
                 Ex. 422 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 activation 
               
               
                 Ex. 423 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 424 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 425 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 426 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 427 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 428 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 429 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 430 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 431 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 432 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 433 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 434 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 435 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 436 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 437 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 438 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 439 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 440 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 441 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 442 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 recombinant protein 
               
               
                 Ex. 443 
                 Sublingual 
                 Solution 
                 HPV16 
                 10 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 recombinant protein 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 20 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 37 
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 444 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 445 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 446 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 447 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 448 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 449 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 450 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 451 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 activation 
               
               
                 Ex. 452 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 activation 
               
               
                 Ex. 453 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 454 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 455 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 456 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 457 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 458 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 459 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 460 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 461 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 462 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 463 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 464 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 465 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 466 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 467 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 468 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 469 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 470 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 471 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 472 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 473 
                 Transnasal 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 21 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 38 
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 474 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 475 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 476 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 477 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 478 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 inhibition 
               
               
                 Ex. 479 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 480 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 mesylate 
                   
                 activation 
               
               
                 Ex. 481 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 activation 
               
               
                 Ex. 482 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 activation 
               
               
                 Ex. 483 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 484 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 485 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 486 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 487 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 488 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 489 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 490 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 491 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 492 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 493 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 494 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 495 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 496 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 497 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 498 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 499 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 500 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                 Ex. 501 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 502 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
               
               
                 Ex. 503 
                 Sublingual 
                 Solution 
                 Live attenuated rotavirus 
                 10 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 (RIX4414 strain) 
                   
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 22 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 39 
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 504 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 505 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 506 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 507 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 508 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 509 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 510 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 511 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 512 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 513 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 514 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 515 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 516 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 517 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 518 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 519 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 520 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 521 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 522 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 523 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 524 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 525 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 526 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 527 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 528 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 529 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 530 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 531 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 532 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 533 
                 Transnasal 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 23 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 40 
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 534 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 535 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 536 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 537 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 538 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 539 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 540 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 541 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 542 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 543 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 544 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 545 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 546 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 547 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 548 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 549 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 550 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 551 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 552 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 553 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 554 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 555 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 556 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 557 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 558 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 589 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 560 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 561 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 562 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
               
               
                 Ex. 563 
                 Sublingual 
                 Solution 
                 Inactivated poliovirus 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 (type 1, type 2, and type 3) 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 24 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 41 
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 564 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 565 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 566 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 567 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 568 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 569 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 570 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 571 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 572 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 573 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 574 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 575 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 576 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 577 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 578 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 579 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 580 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 581 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 582 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 583 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 584 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 585 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 586 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 587 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 588 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 589 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 590 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 591 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 592 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 593 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 25 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 42 
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 594 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 595 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 596 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 597 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 598 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 599 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 600 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 601 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 602 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 603 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 604 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 605 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 606 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 607 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 608 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 609 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 610 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 611 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 612 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 613 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 614 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 615 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 616 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 617 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 618 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 619 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 620 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 621 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 622 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
               
               
                 Ex. 623 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 hepatitis A virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 26 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 43 
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 624 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 625 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 626 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 627 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 628 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 629 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 630 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 631 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 632 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 633 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 634 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 635 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 636 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 637 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 638 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 639 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 640 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 641 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 642 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 643 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 644 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 645 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 646 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 647 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 648 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 649 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 650 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 651 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 652 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 653 
                 Transnasal 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 27 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 44 
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 654 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 655 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 656 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 657 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 658 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 659 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 660 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 661 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 662 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 663 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 664 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 665 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 666 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 667 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 668 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 669 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 670 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 671 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 672 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 673 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 674 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 675 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 676 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 677 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 678 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 679 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 680 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 681 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 682 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
               
               
                 Ex. 683 
                 Sublingual 
                 Solution 
                 Inactivated Japanese 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 encephalitis virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 28 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 45 
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 684 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 685 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 686 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 687 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 688 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 689 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 690 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 691 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 692 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 693 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 694 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 695 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 696 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 697 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 698 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 699 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 700 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 701 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 702 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 703 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 704 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 705 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 706 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 707 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 708 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 709 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 710 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 711 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 712 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 713 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 29 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 46 
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 714 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 715 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 716 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 717 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 718 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 719 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 720 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 721 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 722 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 723 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 724 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 725 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 726 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 727 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 728 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 729 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 730 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 731 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 732 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 733 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 734 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 735 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 736 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 737 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 738 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 739 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 740 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 741 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 742 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
               
               
                 Ex. 743 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 mumps virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 30 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 47 
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 744 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 745 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 746 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 747 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 748 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 749 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 750 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 751 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 752 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 753 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 754 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 755 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 756 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 757 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 758 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 759 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 760 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 761 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 762 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 763 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 764 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 765 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 766 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 767 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 768 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 769 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 770 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 771 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 772 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 773 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 31 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 48 
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 774 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 775 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 776 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 777 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 778 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 779 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 780 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 781 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 782 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 783 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 784 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 785 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 786 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 787 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 788 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 789 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 790 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 791 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 792 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 793 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 794 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 795 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 796 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 797 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 798 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 799 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 800 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 801 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 802 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
               
               
                 Ex. 803 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 measles virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 32 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 49 
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 804 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 805 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 806 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 807 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 808 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 809 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 810 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 811 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 812 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 813 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 814 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 815 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 816 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 817 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 818 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 819 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 820 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 821 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 822 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 823 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 824 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 825 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 826 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 827 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 828 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 829 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 830 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 831 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 832 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 833 
                 Trasnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 33 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 50 
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 834 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 835 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 836 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 837 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 838 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 839 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 840 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 841 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 842 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 843 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 844 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 845 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 846 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 847 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 848 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 849 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 850 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 851 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 852 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 853 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 854 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 855 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 856 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Ticlopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 857 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 858 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 859 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 860 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 861 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 862 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
               
               
                 Ex. 863 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 rubella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 34 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 51 
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 864 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 865 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 866 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 867 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 868 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 869 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 870 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 871 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 872 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 873 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 874 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 875 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 876 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 877 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 878 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 879 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 880 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 881 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 882 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 883 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 884 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 885 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 886 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Ticlopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 887 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 888 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 889 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 890 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 891 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 892 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 893 
                 Transnasal 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 35 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 52 
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 894 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 895 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 896 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 897 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 898 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 899 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 900 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 901 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 902 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 903 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 904 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 905 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 906 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 907 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 908 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 909 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 910 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 911 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 912 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 913 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 914 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 915 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 916 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 917 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 918 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 919 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 920 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 921 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 922 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                 Ex. 923 
                 Sublingual 
                 Solution 
                 
                   Haemophilus influenzae 
                 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 type b polysaccharide- 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
                   
                   
                 tetanus toxoid conjugate 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 36 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 53 
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 924 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 925 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 926 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 927 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 928 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 929 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 930 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 931 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 932 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 933 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 934 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 935 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 936 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 937 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 938 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 939 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 940 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 941 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 942 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 943 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 944 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 945 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 946 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 947 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 948 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 949 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 950 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 951 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 952 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 953 
                 Transnasal 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 37 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 TH2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 54 
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 954 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 955 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 956 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 957 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 958 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 959 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 960 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 961 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 962 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 963 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 964 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 965 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 966 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 967 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 968 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 969 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 970 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 971 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 972 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 973 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 974 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 975 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 976 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 977 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 978 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 979 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 980 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 981 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 982 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
               
               
                 Ex. 983 
                 Sublingual 
                 Solution 
                 Recombinant HBs 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 antigen protein 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 38 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 55 
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 984 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 985 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 986 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 987 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 988 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 989 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 990 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 991 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 992 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 993 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 994 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 995 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 996 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 997 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 998 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 999 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1000 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1001 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1002 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1003 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1004 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1005 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1006 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1007 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1008 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1009 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1010 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1011 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1012 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1013 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 39 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 56 
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1014 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1015 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1016 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1017 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1018 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1019 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1020 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1021 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1022 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1023 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1024 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1025 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1026 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1027 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1028 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1029 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1030 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1031 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1032 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1033 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1034 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1035 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1036 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1037 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1038 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1039 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1040 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1041 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1042 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
               
               
                 Ex. 1043 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 yellow fever virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 40 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 57 
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1044 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1045 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1046 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1047 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1048 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1049 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1050 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1051 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1052 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1053 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1054 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1055 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1056 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1057 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1058 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1059 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1060 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1061 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1062 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1063 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1064 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1065 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1066 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1067 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1068 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1069 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1070 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1071 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1072 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1073 
                 Transnasal 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 41 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 58 
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1074 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1075 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1076 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1077 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1078 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1079 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1080 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1081 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1082 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1083 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1084 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1085 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1086 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1087 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1088 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1089 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1090 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1091 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1092 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1093 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1094 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1095 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1096 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1097 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1098 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1099 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1100 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1101 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1102 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
               
               
                 Ex. 1103 
                 Sublingual 
                 Solution 
                 Tetanus 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 toxoid 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 42 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 59 
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1104 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1105 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1106 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1107 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1108 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1109 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1110 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1111 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1112 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1113 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1114 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1115 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1116 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1117 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1118 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1119 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1120 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1121 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1122 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1123 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1124 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1125 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1126 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1127 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1128 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1129 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1130 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1131 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1132 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1133 
                 Transnasal 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 43 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 60 
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1134 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1135 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1136 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1137 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1138 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1139 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1140 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1141 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1142 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1143 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1144 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1145 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1146 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1147 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1148 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1149 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1150 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1151 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1152 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1153 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1154 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1155 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1156 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1157 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1158 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1159 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1160 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1161 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1162 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
               
               
                 Ex. 1163 
                 Sublingual 
                 Solution 
                 Live attenuated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 varicella virus 
                 100 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 44 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 61 
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1164 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1165 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1166 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1167 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1168 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1169 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1170 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1171 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1172 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1173 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1174 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1175 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1176 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1177 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1178 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1179 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1180 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1181 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1182 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1183 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1184 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1185 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1186 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1187 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1188 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1189 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1190 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1191 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1192 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1193 
                 Transnasal 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 45 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 62 
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1194 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1195 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1196 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1197 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1198 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1199 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1200 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1201 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1202 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1203 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1204 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1205 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1206 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1207 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1208 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1209 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1210 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1211 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1212 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1213 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1214 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1215 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1216 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1217 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1218 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1219 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1220 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1221 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1222 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
               
               
                 Ex. 1223 
                 Sublingual 
                 Solution 
                 Live BCG 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                   
                 30 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 46 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 — 
                 — 
                   
                 10 
               
               
                 Ex. 63 
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1224 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Resveratrol 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1225 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Vinpocetine 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1226 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pimobendan 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1227 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 BRL50481 
                 20 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1228 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Dipyridamole 
                 40 
                 PDE 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1229 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Methoxyphenamine 
                 20 
                 β2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1230 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fenoldopam 
                 20 
                 D1 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1231 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Cisapride 
                 20 
                 5-HT4 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1232 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Desmopressin 
                 20 
                 V2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1233 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prazosin 
                 80 
                 α1,2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1234 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pirenzepine 
                 20 
                 M1 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1235 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Oxybutynin 
                 40 
                 M2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1236 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tolterodine 
                 80 
                 M3 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1237 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fluphenazine 
                 10 
                 D2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1238 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Droperidol 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1239 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sulpiride 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1240 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Azelastine 
                 40 
                 H1 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1241 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Levocetirizine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1242 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Mequitazine 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1243 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Thioperamide 
                 20 
                 H3 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1244 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sarpogrelate 
                 20 
                 5-HT2 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1245 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Clopidogrel 
                 20 
                 P2Y12 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1246 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tiolopidine 
                 40 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1247 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prasugrel 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1248 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Apafant 
                 20 
                 PAF 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1249 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Naloxone 
                 20 
                 μ, κ, σ 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1250 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Zafirlukast 
                 20 
                 CysLT 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1251 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Montelukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1252 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pranlukast 
                 20 
                   
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1253 
                 Transnasal 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Candesartan 
                 20 
                 AT1 
                 10 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 47 
               
             
             
               
                   
                   
               
               
                   
                 Antigen 
                 Th2 reaction promoter 
                   
               
             
          
           
               
                   
                 Administration 
                 Dosage 
                   
                 Amount 
                   
                 Amount 
                 Pharmacological 
                 Amount 
               
               
                   
                 route 
                 form 
                 Name 
                 [μg] 
                 Name 
                 [μg] 
                 effect 
                 [μL] 
               
               
                   
                   
               
             
          
           
               
                 Comp. 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 — 
                 — 
                   
                 30 
               
               
                 Ex. 64 
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1254 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Resveratrol 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1255 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Vinpocetine 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1256 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pimobendan 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1257 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 BRL50481 
                 100 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1258 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Dipyridamole 
                 200 
                 PDE 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 inhibition 
               
               
                 Ex. 1259 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Methoxyphenamine 
                 100 
                 β2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 activation 
               
               
                 Ex. 1260 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fenoldopam 
                 100 
                 D1 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 mesylate 
                   
                 activation 
               
               
                 Ex. 1261 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Cisapride 
                 100 
                 5-HT4 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1262 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Desmopressin 
                 100 
                 V2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 activation 
               
               
                 Ex. 1263 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prazosin 
                 400 
                 α1,2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1264 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pirenzepine 
                 100 
                 M1 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hycrochloride 
                   
                 antagonization 
               
               
                 Ex. 1265 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Oxybutynin 
                 200 
                 M2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1266 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tolterodine 
                 400 
                 M3 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 tartrate 
                   
                 antagonization 
               
               
                 Ex. 1267 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Fluphenazine 
                  50 
                 D2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1268 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Droperidol 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1269 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sulpiride 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1270 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Azelastine 
                 200 
                 H1 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1271 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Levocetirizine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1272 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Mequitazine 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1273 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Thioperamide 
                 100 
                 H3 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1274 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Sarpogrelate 
                 100 
                 5-HT2 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                 hydrochloride 
                   
                 antagonization 
               
               
                 Ex. 1275 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Clopidogrel 
                 100 
                 P2Y12 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1276 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Tiolopidine 
                 200 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1277 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Prasugrel 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1278 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Apafant 
                 100 
                 PAF 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1279 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Naloxone 
                 100 
                 μ, κ, σ 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1280 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Zafirlukast 
                 100 
                 CysLT 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                 Ex. 1281 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Montelukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1282 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Pranlukast 
                 100 
                   
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
               
               
                 Ex. 1283 
                 Sublingual 
                 Solution 
                 Inactivated 
                 Vaccine 
                 Candesartan 
                 100 
                 AT1 
                 30 
               
               
                   
                   
                   
                 rabies virus 
                 200 μL equivalent 
                   
                   
                 antagonization 
               
               
                   
               
             
          
         
       
     
         [0180]    The evaluation of the humoral immunity inducing effect shows that the transmucosal administration (transnasal administration) of a solution for transmucosal administration containing a Th2 reaction promoter (Examples 1 to 30) provides a higher antigen-specific IgG antibody titer than the administration of a solution for transmucosal administration free from a Th2 reaction promoter (Comparative Examples 1 to 8). Although the antigen and the Th2 reaction promoter in the examples were administered in the same formulation, the effect mentioned above can be obtained also when they are in separate formulations and administered separately. Not only in the case of the solution for transmucosal administration, but also in the case of other dosage forms such as solutions for subcutaneous administration or creams for transdermal administration, a high antigen-specific IgG antibody titer as mentioned above can be obtained by preparing an antigen and a Th2 reaction promoter as different formulations and administering them separately. 
         [0000]    
       
         
               
               
               
             
               
               
               
             
           
               
                   
                 TABLE 48 
               
               
                   
                   
               
               
                   
                   
                 Amount 
               
               
                   
                 Additive 
                 [Parts by weight] 
               
               
                   
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 White Vaseline 
                 60.7 
               
               
                   
                 Sorbitan monostearate 
                 0.7 
               
               
                   
                 Isostearic acid 
                 12 
               
               
                   
                 Benzyl alcohol 
                 2.4 
               
               
                   
                 Cetanol 
                 2.4 
               
               
                   
                 Stearyl alcohol 
                 3.5 
               
               
                   
                 Polysorbate 60 
                 3.5 
               
               
                   
                 Concentrated glycerin 
                 2.4 
               
               
                   
                 Purified water 
                 12.4 
               
               
                   
                 Total 
                 100