Abstract:
Systems, methods and computer program products for collecting and analyzing information relating to a physician&#39;s prescription practice in relation to expert best practice guidelines are disclosed. Information relating to a patient specific prescription is collected and analyzed with respect to established expert best practice guidelines. When deviations from the best practice guidelines are identified a tiered intervention information is generated to the physician identifying the nature of the deviation and including suggested changes in the physician&#39;s prescription practice.

Description:
FIELD OF THE INVENTION  
         [0001]    This invention relates generally to systems, methods and computer program products for evaluating prescription practices of a physician in relation to an expert best practice protocol, and further includes a targeted information intervention when an observed prescription practice deviates from said best practice protocol.  
         BACKGROUND OF THE INVENTION  
         [0002]    In recent years increases in the cost of health care has far outpaced other consumer costs. Increasingly employer sponsors of employee health benefit plans and individual consumers have flocked to Health Maintenance Organizations (HMOs) and Preferred Provider Organizations (PPOs) because of their commitment to, and focus on, managing and controlling these escalating costs.  
           [0003]    A significant portion of these increased costs represents an inability to appropriately coordinate or target the appropriate medications and/or treatment for individual patients. Although hospital staff members, numerous health care providers and representatives of the pharmaceutical research and development industry play an important decision-making role in determining the treatment for a disease or condition, that role is still ancillary to the patient&#39;s primary care physician who diagnoses a patient&#39;s problem and prescribes an individualized treatment regimen.  
           [0004]    An important professional activity undertaken by most physicians during the course of their day is the prescribing of therapeutic drugs. Many physicians prescribe a great number of drugs every day. Studies show that over two thirds of all doctor-patient encounters were completed with the writing of a prescription. While most physicians exercise the utmost of professional skill and caution in prescribing, there are inherent difficulties and uncertainties in the process. It has been suggested that most physicians do not have access to adequate, reliable drug information and relevant patient information at the time and point of prescribing. In particular, information regarding relevant new drugs, comparative efficacy, interactions, contraindications, and importantly, relative costs, may not be readily and conveniently available to a physician creating a new prescription.  
           [0005]    Additionally, relevant patient information such as known allergies or other patient-specific contraindications, as well as other conditions currently being treated, other current treatments, and preferred medications for conditions pursuant to the requirements of the patient&#39;s drug formulary, may also not be readily available. As used herein, the term “drug formulary” refers to a list of preferred drugs contained in a drug benefits plan issued by a drugs benefit provider to a given patient.  
           [0006]    Drug formularies are specific to groups of patients and vary in content as between one drug benefit provider and another and one patient group and another. Drug formulary information is usually determinative of the cost-effectiveness of a prescription. Unwitting failure by a prescribing physician to follow formulary guidelines can impose unnecessary or unexpected cost burdens on the patient, and their benefits provider, and lead to poor patient compliance and aggravating and time-consuming disputes. The cost in dollars of non-compliance with drug formulary guidelines to benefit-providing corporations, insurers, health maintenance organizations and government providers, can be enormous. The cost of poor patient compliance may ultimately increase the total cost of care by generating a more serious, expensive adverse health outcome such as an emergency room visit, or hospital admission or even death.  
           [0007]    Integrated patient-specific information which is directly relevant to treatment management for a patient is frequently both unavailable to, and unobtainable by, a prescribing physician unless that physician&#39;s institution or organization has been exhaustively responsible for the patient&#39;s prior care and maintains sophisticated computerized records. Information as to allergies, current prescriptions and currently active conditions and formularies is clearly desirable or essential for intelligent prescribing. However, few prescribing sessions are conducted with the benefits of fully integrated patient-specific information and fewer still have the benefit of specific drug formulary recommendations for the subject patient.  
           [0008]    After consulting with a patient to determine their problems and diagnosing, or attempting to diagnose, their condition or disease, a physician selects a drug and a dosage and an amount to prescribe based upon their own personal knowledge and experience, if necessary using available reference materials which may or may not include published treatment guidelines, promotional materials from drug manufacturers, health-plan formularies and a full knowledge of available alternative drugs. A prescription is then written which bears a patient identification, a drug name, dosage amount, timing of administration, refills available, permissibility of generic substitution, the physician&#39;s signature, the date, and possibly an advisory regarding contraindications, and little other information.  
           [0009]    Additionally, therapeutic treatment regimens are continuously becoming increasingly complex. New data and new therapeutic treatment regimens continue to modify the treatments available, and it is difficult for all but the specialist to remain current on all the latest treatment information. Even those who are current on the latest treatment information require time to assimilate that information and understand how it relates to other treatment information in order to provide the best available care for a patient. Additionally, combination therapeutic treatment regimens exacerbate this problem by increasing the complexity of potential drug interactions. Finally, an increasingly educated and sophisticated patient population, in the face of a vast volume of consumer information on the treatment of disease and rapidly increasing volume of pharmaceutical advertising, makes the mere statement of a treatment regime and the prescription of a therapeutic drug, without explanation, difficult for the patient to accept.  
           [0010]    Numerous prior art attempts have been made to better manage physician prescription practices in light of these available information resources, the growing number of available prescription drugs and the growing prevalence of formularies.  
         DESCRIPTION OF THE RELATED ART  
         [0011]    U.S. Pat. No. 6,188,988 to Barry et al., incorporated herein by reference, discloses a method and apparatus for guiding selection of a therapeutic treatment regimen for a known disease. The method includes evaluating patient information in relation to a plurality of different therapeutic treatment regimens for a diagnosed disease based on a plurality of expert rules for selecting a therapeutic treatment regimen for the disease. Based on patient information and the expert rules, a list of therapeutic treatment regimens for the patient is prepared which includes advisory information for one or more treatment regimens.  
           [0012]    U.S. Pat. No. 6,067,524 to Byerly et al., incorporated herein by reference, discloses a dispensing pharmacy based system and a related method for automatically providing advisory information to pharmacy patients based on the identification of the drugs being dispensed and/or other information pertaining to the patient and to the prescription and/or patient-specific information provided by a third party, such as an HMO, PPO, etc.  
           [0013]    U.S. Pat. No. 6,029,138 to Khorasani et al., incorporated herein by reference, discloses a medication review system wherein a relative frequency with which a treatment regimen has been prescribed for a particular diagnosis code is determined. The relative percentage is compared to a threshold to determine whether a physicians proposed treatment regimen should be accepted. If accepted, feedback, such as the relative frequency with significant therapeutic results of the proffered treatment regimen, can be provided to the ordering physician. Alternative therapeutic treatment can also be suggested by reference to data extracted from existing scientific literature, or by searching for other treatment regimens having the same diagnostic indications but more significant therapeutic results.  
           [0014]    U.S. Pat. No. 6,014,631 to Teagarden et al., incorporated herein by reference, discloses a system wherein, in response to a patient initiated request, a computer program gathers a patient&#39;s therapeutic history including a complete history of medication use, adverse effects, treatment goals, medical history, and patient concerns and satisfaction. A medication profile, including information on current medications and adverse effects, is created and analyzed to evaluate various drug related problems. The patient&#39;s physician is contacted to, for example, verify current medications, discuss potential interventions, establish therapeutic goals, verify adverse drug reactions, and discuss compliance issues. A summary letter is sent to the physician, and a summary of therapy changes is sent to the patient. A call from a pharmacist to the patient, and a health status survey is also sent to the patient. Examples of drug related problems can include: untreated indications, and including therapeutic failures; drug use without an indication; improper drug selection, and including therapeutic duplications; improper dosage; interactions, e.g., drug-drug, drug-food and drug-disease; inadequate drug delivery, and including non-compliance; adverse reactions; and improper monitoring.  
           [0015]    U.S. Pat. Nos. 5,953,704 and 5,583,758 to McIlroy et al., incorporated herein by reference, discloses a data base of diagnosis-based guidelines developed by medical professionals and provides a diagnosis based system that can be used during various steps of the clinical decision process. A user inputs an individual&#39;s health data into a case file in response to inquiries implemented in a health-condition specific guideline. A guideline treatment option (or options) is obtained. The user may adopt or accept the guideline treatment option(s) or input an alternative actual or proposed treatment. Discrepancies between actual or proposed and guideline treatment option(s) are identified and the physician&#39;s choice is documented. Once a treatment is selected, the case information is added to the data base and a reviewer can analyze the file. Once guideline treatment options are identified, the system elicits from the user information identifying the actual treatment already given or, preferably, the treatment proposed for the individual that presented the health care condition. The system compares the actual or proposed treatment against the guideline treatment option(s). The system develops a treatment evaluation based on the comparison to identify discrepancies between the guideline treatment option and the actual or proposed treatment. If the proposed treatment differs from the guideline treatment option, the system elicits information on the reasons for the difference(s) found in the system&#39;s comparison.  
           [0016]    U.S. Pat. No. 5,924,074 to Evans, incorporated herein by reference, discloses a system having medication data and guideline data and which includes patient data and practice guidelines. The practice guidelines provide references for practitioners to consult regarding courses of action to obtain a diagnosis and alternative treatments for various conditions. A physician can review the patient&#39;s history by viewing a medication history and a diagnosis history before prescribing any new medications. The physician selects a medication by entering the name of the medication. If there are no contraindications or allergies for the patient, the physician can prescribe the medication. Otherwise, if a contraindication exists, a warning appears to alert the physician. In view of the warning, the physician can investigate the effects of the medication. A medication&#39;s interactions is provided. An allergy list displays the patient&#39;s allergens. The physician can then evaluate the information on the interactions, including potential adverse patient reactions. The physician can make any needed revisions to the medications selected.  
           [0017]    U.S. Pat. No. 5,924,073 to Tyuluman et al., incorporated herein by reference, discloses a system and method for analyzing and defining a standard of care that identifies components of patient care which are more costly to implement, have greater risk exposure, or include ineffective treatment, compared to recommended methods that attain the same or better results for a patient. A standard of care that should be followed based on the characteristics of a particular patient is provided. Physicians who are able to deliver the same or better treatment with significantly lower cost or less exposure to risk are identified as performing above the standard of care. The methods of these physicians are evaluated and made available to the health care community at large. The standard of care is progressively and automatically redefined in an effort to continuously improve the overall quality and cost of care.  
           [0018]    U.S. Pat. No. 5,845,255 to Mayaud, incorporated herein by reference, discloses a drug management system classified by conditions for which they are known to have a therapeutic effect.  
           [0019]    Based on a patient&#39;s condition, the system provides a list of suggested drugs for treating the condition. Drug selection can be refined into categories such as relative cost, relative frequency prescribed, and generic vs. brand name. Where multiple drugs are available for treating an active condition, multiple lines of therapeutic preference according to drug formulary guidelines can be provided. Different suggestions can be provided for different patients according to the preferences of the patient&#39;s particular drugs benefit plan, and the resultant prescribing practices of a physician can be reviewed and analyzed by a health benefit plan, such as an HMO, to assess physician compliance.  
           [0020]    Where the physician knows that formulary drugs in a similar class have been tried and found ineffective and that the condition is beyond first line treatments, the physician can select a non-formulary drug or a drug in a different chemical category having different therapeutic properties from those previously applied.  
           [0021]    Feedback can be provided that the selected drug is a non-formulary drug or is not on the patient&#39;s prescription benefit company&#39;s schedule. The system can optionally scan a drug preference database, maintained, for example, by a managed care organization, HMO, or prescription benefits management company, and the selected patient&#39;s history record for an evaluation of the merits of the selected drug for treating the condition. A message, advising the physician that the selected drug is not a first line drug for treating the selected condition can be provided. In accordance with the benefit company&#39;s standards or based on objective literature reports, alternative drugs from listings in the drug preference database can be suggested as more meritorious in treatment of the condition in question. Treatment information can include literature references supporting the system&#39;s recommendation. Optionally a copy of such a study can be provided to the physician. Available treatment guidelines information can include details of the particular conditions for which a suggested alternative drug has been found effective, adverse conditions, preferred dosages and administration routes, and literature sources.  
           [0022]    U.S. Pat. No. 5,724,379 to Perkins et al., incorporated herein by reference, discloses a method of classifying health care services provided to a patient group based on an objective quantifiable metric. Performance metrics can be identified for the population group. Individual metrics for each of a set of identified service providers can be compared to corresponding population based metrics. Feed back is provided to providers whose individual performance metric deviates significantly from the larger population based metric so that the service provider can alter their behavior in conformance with the broader population based metric. Similar comparative information is provided to benefits providers such as HMOs.  
           [0023]    In spite of the numerous existing or published patents, there remains a need for a system and method that, solely in reliance on prescription data, can provide clinically and economically meaningful data analysis of physician prescribing practices; and which, based on this analysis, can recommend targeted interventions to produce measurable changes at the patient, practitioner and health plan levels.  
         SUMMARY OF THE INVENTION  
         [0024]    Accordingly, it is an object of the present invention to improve clinical outcomes and to promote cost effective prescribing practices without the use of a prior authorization or restriction to a pharmacy formulary by monitoring and intervening, where appropriate, to improve the quality of clinical care, utilizing easy to recover prescription data for profiling physician prescribing practices that are less than optimum.  
           [0025]    It is a further object of the present invention to provide an automated system and method to identify physicians whose prescribing practices result in abnormally high prescription costs as compared to other physicians.  
           [0026]    It is a further object of the present invention to provide an automated system and method to identify patients whose prescription costs are abnormally high as compared to other patients with similar conditions.  
           [0027]    It is a further object of the present invention to provide an automated system and method to identify instances where high cost drugs therapies are being prescribed where alternative lower cost drug therapies are available.  
           [0028]    It is yet a further objective of the present invention to provide an automated system and method to identify organizations, or groups whose population&#39;s per-capita prescription costs are abnormally high as compared to per-capita prescription costs of other group populations.  
           [0029]    An object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices involving excess dosing in comparison to expert dosing guidelines.  
           [0030]    A further object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices involving inadequate or ineffective dosing in comparison to expert dosing guidelines.  
           [0031]    A further object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices with the potential for drug-drug interactions.  
           [0032]    A further object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices involving cost-ineffective pill strength selection.  
           [0033]    A further object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices involving use of two or more drugs from the same chemical class.  
           [0034]    A further object of a particularly preferred embodiment of the present invention is to identify prescription discontinuance histories and untimely refills.  
           [0035]    A further object of a particularly preferred embodiment of the present invention is to identify physician prescribing practices involving use of brand-name drugs where generic equivalents are available.  
           [0036]    A further object of a particularly preferred embodiment of the present invention is to identify patients having multiple prescribing physicians who may not be aware of the existence of each other, with respect to that particular patient, and therefore may be unaware of other drugs that may have been prescribed by the other physician.  
           [0037]    An object of a particular embodiment of the present invention involving behavioral pharmaceuticals is to identify therapeutic duplications of atypical anti-psychotic medications.  
           [0038]    An further object of a particular embodiment of the present invention involving behavioral pharmaceuticals is to identify use of sedatives/hypnotics for greater than 30 days.  
           [0039]    These and other objects of the present invention are achieved by a highly targeted strategy that finds opportunities for direct physician intervention to improve prescribing practices, to improve patient compliance, and to assist physicians in obtaining the most current information on expert preferred practices and treatments. The system and method of the present invention can be provided as a stand alone service or adapted as a value added service to an existing pharmacy benefit management product.  
           [0040]    By relying upon national standards such as the published Expert Consensus Guideline Series, a panels of experts, and training and management of continuing medical education (CME) events, the system and method of the present invention has the ability to identify clinical problems and initiate a highly credible series of educational interventions that are acceptable to prescribing physicians.  
           [0041]    A first particular embodiment of the system and method of the present invention provides an analysis of data against ten quality metrics which are designed to highlight potential problems and opportunities for improving care. However, as would be obvious to those skilled in the art, additional or modified metrics can be introduced and adapted to analytical findings—thus a continuous quality improvement feature can be maintained.  
           [0042]    In the system and method of the present invention data analysis is automated and a variety of useful reports can also be generated that identify opportunities for improvement at the health plan, practitioner and patient level. Additionally, the present invention provides expert review of these reports to help the health system tailor targeted and specific educational and managerial interventions to improve patient care.  
           [0043]    In a particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of one intervention information. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of two different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of three different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of four different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of five different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of six different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of seven different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of eight different intervention informations. In another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of nine different intervention informations. Finally, in another particularly preferred embodiment of the present invention, analysis of a doctor&#39;s prescription practices can give rise to generation of ten different intervention informations.  
           [0044]    In a currently preferred embodiment of the present invention the intervention informations can be provided to doctors and health plan medical directors via: letters sent by mail, e-mail, direct computer-to-computer messaging, face-to-face personally, a personal telephone call, automated telephone messaging, and by facsimile. Intervention informations can also be provided by other forms of communication.  
           [0045]    One preferred embodiment of the invention describes a method for providing an intervention information based solely on prescription data, said method comprising the steps of: providing a prescription data;  
           [0046]    providing a reference guideline;  
           [0047]    defining a comparative metric;  
           [0048]    comparing said prescription data to said reference guideline on a basis of said metric;  
           [0049]    computing a deviation of said metric as a difference between said prescription data and said reference guideline;  
           [0050]    comparing said deviation to a threshold deviation; and  
           [0051]    if said deviation exceeds said threshold deviation, providing said intervention information.  
           [0052]    Another preferred embodiment of the invention described a computer system having a computer program set of instructions stored thereon that when executed can perform a method for providing an intervention information based solely on a pharmaceutical prescription, said system comprising:  
           [0053]    a computer;  
           [0054]    a first memory connected to said computer, said first memory having a computer program set of instructions for performing a method for reviewing and analyzing a pharmaceutical prescription stored thereon;  
           [0055]    a second memory connected to said computer, said second memory having at least one pharmaceutical prescription record stored thereon; and  
           [0056]    a third memory connected to said computer, said third memory having at least one expert guideline stored thereon.  
           [0057]    Another preferred embodiment of the present invention describes a computer program for providing an intervention information based solely of data derived from a pharmaceutical prescription data, said computer program comprising a plurality of programed intervention informations outputs.  
           [0058]    A further preferred embodiment of the invention describes an intervention information based solely on data derived from a pharmaceutical prescription data, said intervention information produced by a process of:  
           [0059]    providing a prescription data;  
           [0060]    providing a reference guideline;  
           [0061]    defining a comparative metric;  
           [0062]    comparing said prescription data to said reference guideline on a basis of said metric;  
           [0063]    computing a deviation of said metric as a difference between said prescription data and said reference guideline;  
           [0064]    comparing said deviation to a threshold deviation; and  
           [0065]    if said deviation exceeds said threshold deviation, providing said intervention information.  
           [0066]    Additionally, in another preferred embodiment of the present invention intervention informations can include citation to published expert studies, reports and guidelines. In a further preferred embodiment of the present invention the intervention informations can include, appended thereto, copies of cited or referenced published expert studies, reports and guidelines.  
           [0067]    These and other objects, features and advantages of the invention will be better understood by those skilled in the art by reference to the following detailed description taken together with the following drawings in which like numerals identify like elements throughout the several views. 
       
    
    
     BRIEF DESCRIPTION OF THE FIGURES  
       [0068]    [0068]FIG. 1 is a schematic representation of a prior art network linking a patient&#39;s prescription through a pharmacy computer to a clearing house computer system.  
         [0069]    [0069]FIG. 2 is a schematic representation of a computer system architecture of the present invention.  
         [0070]    [0070]FIGS. 3 a - 3   b  are excerpts from an example of a prior art Expert Consensus Guideline for Medication Treatment of Bipolar Disorder.  
         [0071]    [0071]FIGS. 4 a - 4   b  are excerpts from an example of a prior art Expert Consensus Guideline for Treatment of Agitation in Older Persons with Dementia.  
         [0072]    [0072]FIG. 5 is an overview of a schematic flowchart of the analysis and intervention method of the present invention.  
         [0073]    [0073]FIG. 6 a  is a schematic flowchart of the analysis and intervention method for therapeutic duplication of atypical anti-psychotics of FIG. 5.  
         [0074]    [0074]FIG. 6 b  is an example of an intervention letter produced by the method of FIG. 6 a.    
         [0075]    [0075]FIG. 7 a  is a schematic flowchart of the analysis and intervention method for excess dosing of FIG. 5.  
         [0076]    [0076]FIG. 7 b  is an example of an intervention letter produced by the method of FIG. 7 a.    
         [0077]    [0077]FIG. 8 a  is a schematic flowchart of the analysis and intervention method for inadequate dosing of FIG. 5.  
         [0078]    [0078]FIG. 8 b  is an example of an intervention letter produced by the method of FIG. 8 a.    
         [0079]    [0079]FIG. 9 a  is a schematic flowchart of the analysis and intervention method for drug/drug interactions of FIG. 5.  
         [0080]    [0080]FIG. 9 b  is an example of an intervention letter produced by the method of FIG. 9 a.    
         [0081]    [0081]FIG. 10 a  is a schematic flowchart of the analysis and intervention method for cost-ineffective pill strength selection of FIG. 5.  
         [0082]    [0082]FIG. 10 b  is an example of an intervention letter produced by the method of FIG. 10 a.    
         [0083]    [0083]FIG. 11 a  is a schematic flowchart of the analysis and intervention method for multiple drugs in same chemical class of FIG. 5.  
         [0084]    [0084]FIG. 11 b  is an example of an intervention letter produced by the method of FIG. 11 a.    
         [0085]    [0085]FIG. 12 a  is a schematic flowchart of the analysis and intervention method for patient adherence of FIG. 5.  
         [0086]    [0086]FIG. 12 b  is an example of an intervention letter produced by the method of FIG. 12 a.    
         [0087]    [0087]FIG. 13 a  is a schematic flowchart of the analysis and intervention method for brand vs. generics of FIG. 5.  
         [0088]    [0088]FIG. 13 b  is an example of an intervention letter produced by the method of FIG. 13 a.    
         [0089]    [0089]FIG. 14 a  is a schematic flowchart of the analysis and intervention method for a patient receiving prescriptions from multiple doctors of FIG. 5.  
         [0090]    [0090]FIG. 14 b  is an example of an intervention letter produced by the method of FIG. 14 a.    
         [0091]    [0091]FIG. 15 a  is a schematic flowchart of the analysis and intervention method for long-term usage of FIG. 5.  
         [0092]    [0092]FIG. 15 b  is an example of an intervention letter produced by the method of FIG. 15 a.    
     
    
     DETAILED DESCRIPTION  
       [0093]    Referring to FIG. 1, a patient (not shown) belonging to a health benefit plan (not shown) such as a Health Maintenance Organization (HMO), a-Preferred Provider Plan (PPO), a traditional health insurance indemnity plan, a government subsidized medical benefit plan such as Medicare, or another type of health benefit plan presents, in a conventional manner, a prescription  100  to a pharmacy (not shown) to be filled in accordance with a doctor&#39;s instructions written thereon. A pharmacist (not shown) enters data  110  from prescription  100  into pharmacy computer  105  in a conventional manner. Data  110  comprises patient name  112 , benefit plan registration number  114 , physician name  116 , Drug Enforcement Agency (DEA) number  118 , drug code (NDC)  120 , dosage  122 , dispensing quantity  124 , number of prescribed refills  126 , prescription date  128 , administration instructions, and other relevant data (not shown).  
         [0094]    Pharmacy computer  105  is connected in a conventional manner by communications link  130  to a clearing house computer  135 . Clearing house computer can be integral with pharmacy computer  105  or can be located remote therefrom. Computer  105  transmits data  110  to computer  135  across communications link  130 . Based on benefit plan registration number  114 , computer  135  validates in a conventional manner the patient&#39;s participation in the health benefit plan. If validated, computer  135  returns, in a conventional manner as is known in the art, an authorization data (not shown) and a patient co-payment amount (not shown) to computer  105  via link  130 . The pharmacy then fills prescription  100  in a conventional manner at which time the prescribed drug can be dispensed to the patient and the patient&#39;s co-payment amount, if any, can be collected from the patient. Computer  135  can also return other data to computer  105  such as: invalid patient identification (not shown), patient&#39;s health plan participation expired (not shown), reimbursement amount to be paid to the pharmacy by the health plan (not shown), warning information to be provided to the patient (not shown), and other data.  
         [0095]    Referring now to FIG. 2, computer  135  is connected by a communications link  205  to a monitoring/analysis computer  210  having a processor and at least one memory connected thereto. Monitoring computer  210  can be the same computer as pharmacy computer  105 , clearing house computer  135 , a separate health benefits plan&#39;s computer, or a separate third-party monitoring service&#39;s computer. A first memory  215  having analysis program  220  of the present invention stored thereon is connected to computer  210 . A second memory  225  is also connected to computer  210 . Memory  225  has a prescription history database  230  stored thereon. Prescription history database  230  has a plurality of prescription records  230   1  . . .  230   i  . . .  230   z  stored therein. For each prescription  100  submitted and filled by a pharmacy for a patient participating in a health plan, computer  135  transmits prescription data  110  to monitoring computer  210 . Monitoring computer  210  stores prescription data  110  corresponding to prescription  100  in prescription history data base  230  as prescription record  230   n .  
         [0096]    A third memory  235  is also connected to computer  210 . Memories  215 ,  225  and  235  can be the same physical memory device or can be separate physical memory devices. Memory  235  has an expert consensus guidelines database  240  stored thereon. Guidelines database  240  has a plurality of expert guidelines records  240   1  . . .  240   1  . . .  240   z  stored therein in a computer readable form. FIGS. 3 a - 3   b  show an exemplary hardcopy version of a particular expert consensus guideline for medication treatment of bipolar disorder, such as can be stored in one of the plurality of expert guidelines records, such as record  240   j ; and FIGS. 4 a - 4   b  show another exemplary hardcopy version of a particular expert consensus guideline for treatment of agitation in older persons with dementia, such as can be stored in another of the plurality of expert guidelines records, such as record  240   k . Other expert consensus guidelines (not shown) for other diseases, conditions and drugs can be similarly stored in other of the plurality of expert guidelines records of expert guidelines database  240 .  
         [0097]    Referring to FIG. 5, a flowchart of a computerized analysis and intervention program  220  of the method of the present invention is shown. Program  200  is loaded into and executed in the processor of computer  210 . A conventional database management program  500  also runs on computer  210  in a background which receives prescription records from computer  135  and stores them into database  240  as records  240   1  . . .  240   z  by process  502 . Decision box  504  determines if additional prescription records are to be stored. If additional prescriptions are to be stored control returns to process  500  via link  506 . If no further prescriptions are to be stored, control passes via link  508  to process  510  where an analysis type of the present invention is selected. The analysis selection can be either manually initiated, or computer initiated based, for example, on a schedule analysis cycle, or some other criteria such as a particular patient or doctor or a particularized period of time. A single type analysis (such as shown in any of blocks  512 - 530 ) or multiple analyses (encompassing more than one of blocks  512 - 530 ) can be selected.  
         [0098]    In a currently preferred embodiment of the present invention directed to psychotropic drugs, one or more of ten different analysis types can be selected. When a therapeutic duplication analysis is run, program  200  advances to process  512  as more particularly described in FIG. 6 a . When an excess dosing analysis is run, program  200  advances to process  514  as more particularly described in FIG. 7 a . When a inadequate dosing analysis is run, program  200  advances to process  516  as more particularly described in FIG. 8 a . When a drug/drug interaction analysis is run, program  200  advances to process  518  as more particularly described in FIG. 9 a . When a pill strength selection analysis is run, program  200  advances to process  520  as more particularly described in FIG. 10 a . When a multiple drugs/same class analysis is run, program  200  advances to process  522  as more particularly described in FIG. 11 a . When a patient adherence analysis is run, program  200  advances to process  524  as more particularly described in FIG. 12 a . When a generics analysis is run, program  200  advances to process  526  as more particularly described in FIG. 13 a . When a multiple doctors analysis is run, program  200  advances to process  528  as more particularly described in FIG. 14 a ; and when a long term usage analysis is run, program  200  advances to process  530  as more particularly described in FIG. 15 a.    
         [0099]    With reference to FIG. 6 a , step  5110  of program  220  performs a query of database  230  to identify all prescription records  230   j  where atypical antipsychotics (as determined by NDC  120 ) have been prescribed. In step  5120  the records  230   j  of the prescribed atypical antipsychotics are further queried to identify those specific patients (as determined by benefit plan registration number  114 ) who have been prescribed multiple atypical antipsychotics and a particular combination of atypicals that have been prescribed to them. For each patient having a combination of prescribed atypicals, process  5130  queries expert consensus database  240  to find any applicable expert consensus record  240   j  regarding the particular combination of atypicals prescribed to that patient. If an expert consensus record  240   k  supports the duplication, decision block  5140  returns program  220  via links  5150  and  5160  to step  5120  for a next patient having an atypical duplication. If the duplication is advised against by expert consensus record  240   k , program  220  identifies the doctor(s)  116  prescribing the atypicals to the patient, and in step  5180  initiates creation and furnishing of an intervention information, such as shown in FIG. 6 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5190  and  5160  to step  5120  to repeat the analysis for a next patient.  
         [0100]    With reference to FIG. 7 a , step  5210  of program  220  performs a query of database  230  to identify all prescription records  230   j  with their corresponding prescribed drug (as determined by NDC  120 ) and dosage  122 . For each prescription record  230   j  step  5220  queries expert consensus database  240  to find any applicable expert consensus record  240   j  which defines the recommended daily maximum dosage (not shown). If the prescribed dosage  122  does not exceed a recommended maximum dosage, decision block  5230  returns program  220  via links  5240  and  5250  to step  5210  for a next prescription record  230   j+1 . If the prescribed dosage  122  exceeds the maximum recommended daily dosage, step  5260  of program  220  identifies the doctor(s)  116  prescribing the high dosage to the patient, and in step  5270  initiates creation and furnishing of an intervention information, such as shown in FIG. 7 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5280  and  5250  to step  5210  to repeat the analysis for a next prescription.  
         [0101]    With reference to FIG. 8 a , step  5310  of program  220  performs a query of database  230  to identify all prescription records  230   j  with their corresponding prescribed drug (as determined by NDC  120 ) and dosage  122 . Step  5310  can be the same step as step  5210  as shown in FIG. 7 a . For each prescription record  230   j  step  5320  queries expert consensus database  240  to find any applicable expert consensus record  240   j  which defines the recommended daily minimum effective dosage (not shown). Step  5320  can be performed concurrent with step  5220  as shown in FIG. 7 a . If the prescribed dosage  122  is not less than a recommended minimum effective dosage, decision block  5330  returns program  220  via links  5340  and  5350  to step  5310  for a next prescription record  230   j+1 . If the prescribed dosage  122  is less than a recommended minimum effective daily dosage, step  5360  of program  220  identifies the doctor(s)  116  prescribing the low dosage to the patient, and in step  5370  initiates creation and furnishing of an intervention information, such as shown in FIG. 8 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5380  and  5350  to step  5310  to repeat the analysis for a next prescription.  
         [0102]    With reference to FIG. 9 a , step  5410  of program  220  performs a query of database  230  to identify all patients taking multiple prescriptions. For each patient taking multiple prescriptions, step  5420  identifies that patient&#39;s prescription records  230   j  . . .  230   m  to determine all of the prescribed drugs (as determined by NDC  120 ) taken by the patient. At step  5430  expert consensus database  240  is queried to find any applicable expert consensus record  240   j  which defines if any combination of the drugs taken by the patient can potentially result in an adverse reaction or is otherwise contraindicated. If none of the combinations of drugs results in an adverse reaction or is otherwise contraindicated, decision block  5440  returns program  220  via links  5450  and  5455  to step  5460  where a next patient is identified and then returns program  220  to step  5420 . If in decision step  5440  a combination of drugs taken by the patient is identified as potentially giving rise to an adverse reaction or is otherwise contraindicated, program  220  advances to step  5470  which identifies the doctor(s)  116  prescribing the potentially interacting drugs to the patient. Program  220  then advances to step  5480  which initiates creation and furnishing of an intervention information, such as shown in FIG. 9 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor(s). Additionally, due to the urgency of the potential interaction, an immediate contact with the prescribing doctor(s) is initiated by telephone, facsimile, direct computer-to-computer communication, e-mail, or otherwise. Program  220  then returns via links  5490  and  5455  to step  5460  which advances program  220  to a next patient and then returns via link  5465  to step  5420  to repeat the analysis for that next patient.  
         [0103]    With reference to FIG. 10 a , step  5510  of program  220  performs a query of database  230  to identify, for each patient prescription record  230   j , a pill strength (as determined by NDC  120 ) and dosing  122 . At step  5520  expert consensus database  240  is similarly queried to find any applicable expert consensus record  240 , which defines a recommended combination of pill strength and dosing. If the prescribed combination of pill strength and dosing fall within a range of recommended combinations of pill strength and dosing, decision block  5530  returns program  220  via links  5540  and  5545  to step  5550  where a next patient is identified and then returns program  220  to step  5510 . If decision step  5530  determines that the combination of prescribed pill strength and dosing fall outside the recommended range of combinations of pill strength and dosing, program  220  advances to step  5560  which identifies the doctor(s)  116  prescribing the non-recommended combination of pill strength and dosing. Program  220  then advances to step  5570  which initiates creation and furnishing of an intervention information, such as shown in FIG. 10 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5580  and  5545  to step  5550  which advances program  220  to a next patient and then returns via link  5555  to step  5510  to repeat the analysis for that next patient.  
         [0104]    With reference to FIG. 11 a , step  5610  of program  220  performs a query of database  230  to identify all patients taking multiple prescriptions prescribed by the same doctor  116 . Step  5610  is similar to step  5410  previously described with respect to FIG. 9 a  and can be simultaneously performed. For each patient taking multiple prescriptions, step  5620  identifies that patient&#39;s prescription records  230   j  . . .  230   m  to determine all of the prescribed drugs (as determined by NDC  120 ) taken by the patient. Step  5620  is similarly analogous to step  5420  previously described with respect to FIG. 9 a  and can likewise be simultaneously performed. At step  5630  expert consensus database  240  is queried to find any applicable expert consensus record  240   j  which, for the respective patient, defines if any combination of the drugs identified in step  5620  belong to a same chemical class. If none of the combinations of drugs belong to the same chemical class, decision block  5640  returns program  220  via links  5645  and  5650  to step  5655  where a next patient is identified and then returns program  220  to step  5620 . If in decision step  5640  a combination of drugs taken by the patient is identified as belonging to the same chemical class, program  220  advances to step  5670  which identifies the doctor  116  prescribing the drugs of the combination belonging to the same class. Program  220  then advances to step  5680  which initiates creation and furnishing of an intervention information, such as shown in FIG. 11 b  in the form of a letter with citations to reference publications, that is provided to the prescribing doctor. Program  220  then returns via links  5690  and  5650  to step  5655  which advances program  220  to a next patient and then returns via link  5660  to step  5620  to repeat the analysis for that next patient.  
         [0105]    With reference to FIG. 12 a , step  5710  of program  220  performs a query of database  230  to identify, for each patient prescription record  230   j , if refills  126  are permitted. For each prescription record  230   j  identified in step  5710 , step  5720  identifies any additional prescription records  230   j+1 , for the same drug  120  and dose  122  having a date  128  subsequent to the date  128  of a first occurring prescription record  230   j  identified in step  5710 . At decision block  5730  the timeliness of the respective prescription refills is determined by comparing the respective dates  128  of the refills to expected dates (not shown) on which the prescription should theoretically have been refilled based on a quantity  124  prescribed and a dosing  122 . If the prescription refill was timely filled, step  5730  returns program  220  via links  5740  and  5750  to step  5710  to repeat the analysis for another prescription record  230   j+x . If decision block  5730  determines that the prescription was either not timely refilled or was not refilled at all, program  220  advances to step  5760  which identifies the doctor(s)  116  prescribing the non-refilled drug. Program  220  then advances to step  5770  which initiates creation and furnishing of an intervention information, such as shown in FIG. 12 b  in the form of a letter, which can include citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5780  and  5750  to step  5710  to repeat the analysis for that next prescription.  
         [0106]    With reference to FIG. 13 a , step  5810  of program  220  performs a query of database  230  to identify each prescription record  230   j , which prescribed a non-generic drug (as determined by NDC  120 ).  
         [0107]    For each prescription record  230   j  identified in step  5810 , step  5820  queries expert consensus guidelines database  240  to find any applicable expert consensus record  240   j  which defines if a generic equivalent of the prescribed drug is available. If a generic equivalent is not available, decision block  5830  returns program  220  via links  5840  and  5850  to step  5810  to repeat the analysis for another non-generic prescription record  230   j+1 . If decision block  5830  determines that a generic equivalent for the drug is available, program  220  advances to step  5860  which identifies the doctor(s)  116  prescribing the non-generic drug. Program  220  then advances to step  5870  which initiates creation and furnishing of an intervention information, such as shown in FIG. 13 b  in the form of a letter, which can include citations to reference publications, that is provided to the prescribing doctor(s). Program  220  then returns via links  5880  and  5850  to step  58710  to repeat the analysis for that next non-generic prescription.  
         [0108]    With reference to FIG. 14 a , the method of FIG. 14 a  is similar to the method of FIG. 11 a  with the exception that FIG. 11 a  describes the situation of multiple prescriptions for drugs in the same chemical class with both drugs being prescribed to a patient by a singular doctor. FIG. 14 a  similarly addresses multiple prescriptions for drugs in the same chemical class. However, in FIG. 14 a , the drugs in the same chemical class that are prescribed to a patient are prescribed by two or more different doctors.  
         [0109]    At step  5910  program  220  performs a query of database  230  to identify all patients taking prescriptions prescribed by different doctors  116 . For each patient taking prescriptions from multiple doctors, step  5920  identifies that patient&#39;s prescription records  230   j  . . .  230   m  to determine all of the prescribed drugs (as determined by NDC  120 ) taken by that patient. At step  5930  expert consensus database  240  is queried to find any applicable expert consensus record  240   j  which, for the respective patient, defines if any combination of the drugs identified in step  5920  belong to a same chemical class. If none of the combinations of drugs belong to the same chemical class, decision block  5940  returns program  220  via links  5945  and  5950  to step  5955  where a next patient is identified and then returns program  220  to step  5920 . If in decision step  5940  a combination of drugs taken by the patient is identified as belonging to the same chemical class, program  220  advances to step  5970  which identifies the individual doctors  116  of the multiple doctors prescribing the drugs of the combination belonging to the same class. Program  220  then advances to step  5980  which initiates creation and furnishing of an intervention information, such as shown in FIG. 14 b  in the form of a letter with citations to reference publications, that is provided to the health plan medical director and can be provided to each of the prescribing doctors. Program  220  then returns via links  5990  and  5950  to step  5955  which advances program  220  to a next patient and then returns via link  5960  to step  5920  to repeat the analysis for that next patient.  
         [0110]    With reference to FIG. 15 a , step  6010  of program  220  performs a query of database  230  to identify all prescription records  230   j  for a desired class of drugs such as sedatives and hypnotics (as determined by NDC  120 ). For each prescription record  230   j , together with its allowed refills  126 , step  6020  determines the number of days of medication prescribed. At step  6030  expert consensus database  240  can queried to find any applicable expert consensus record  240   j  which, for the respective prescription, defines a recommended maximum number of days of medication. Alternatively, a user defined threshold maximum number of days of medication can be provided. Decision block  6040  compares the recommended maximum number of days of medication with the number of days of medication actually prescribed. If the number of days of medication prescribed does not exceed the recommended maximum threshold, decision block  6040  returns program  220  via links  6050  and  6060  to step  6010 . If in decision step  6040  the number of days of medication prescribed exceeds the recommended maximum threshold, program  220  advances to step  6070  which identifies the doctor(s)  116  prescribing the drugs. Program  220  then advances to step  6080  which initiates creation and furnishing of an intervention information, such as shown in FIG. 15 b  in the form of a letter which can include citations to reference publications, that is provided to the doctor. Program  220  then returns via links  6090  and  6060  to step  6010  to repeat the analysis for that next prescription.  
         [0111]    In addition to the particularized analyses described above with reference to FIGS. 5 and 6 a/b - 15   a/b , additional summary reports which, by way of example and not by way of limitation, can be provided to a health plan medical director which report: doctors writing a disproportionately high number of prescriptions and doctors whose prescriptions are disproportionately high in cost.  
         [0112]    Also, although the system and method of the present invention have been described above with respect to a particular embodiment directed to psychotropic drugs, the system and method of the present invention are also useful for other types of drugs and disease states for which the above described intervention informations can be modified to correspond to the context of the particularized application. Examples of such other drugs and disease states follow:  
       OTHER EXAMPLES  
     Example I.  
     Alzheimer&#39; Disease Management  
       [0113]    B. Cholinesterase Inhibitors  
         [0114]    1. Donepezil HCL (Aricept)  
         [0115]    2. Tacrine (Cognex)  
         [0116]    3. Rivastigmine (Exelon)  
         [0117]    C. Gama Secretase Inhibitors  
         [0118]    1. None marketed now (in development)  
         [0119]    Exemplary Quality Audits/Quality Letters:  
         [0120]    Therapeutic duplication of cholinesterase inhibitors;  
         [0121]    Excess Dosing;  
         [0122]    Inadequate dosing;  
         [0123]    Dosing Initiation and Titration;  
         [0124]    Timing of the Dosages and Administration Instructions;  
         [0125]    Drug/drug interaction;  
         [0126]    Cost ineffective pill strength selection;  
         [0127]    No timely refill (patient adherence);  
         [0128]    Patient with two or more physicians.  
       Example II.  
     Analgesics  
       [0129]    A. Acetaminophen and Combinations  
         [0130]    1. Excedrin Migraine products  
         [0131]    2. Tylenol products  
         [0132]    B. Centrally Acting  
         [0133]    1. Ultram (tramadol)  
         [0134]    2. Duraclon (clonidine HCL injection)  
         [0135]    C. Narcotic Analgesics (Agonist-Antagonist &amp; Combinations) Controlled Substances  
         [0136]    1. Buprenex Injectable (buprenorphine)  
         [0137]    2. Nubain Injection (nalbuphine)  
         [0138]    3. Stadol NS (butorphanol)  
         [0139]    4. Talacen (pentazocine/acetaminophen)  
         [0140]    5. Talwin Nx (pentazocine/naloxone)  
         [0141]    6. Talwin compound (pentazocine/aspirin)  
         [0142]    D. Narcotics and Combinations: Controlled Substances  
         [0143]    1. Actiq (fentanyl)  
         [0144]    2. Astramorph/PF injection (morphine sulfate injection)  
         [0145]    3. Darvocet (propoxyphene napsylate/acetaminophen)  
         [0146]    4. Darvon (propoxyphene hydrochloride)  
         [0147]    5. Demerol (meperidine)  
         [0148]    6. Dilaudid (hydromorphone)  
         [0149]    7. Duragesic Transdermal System (fentanyl)  
         [0150]    8. Duramorph injection (morphine sulfate injection)  
         [0151]    9. Infumorph 200/500 (morphine sulfate preservative-free)  
         [0152]    10. Kadian capsules (morphine sulfate sustained release)  
         [0153]    11. Levo-Dromoran tablets/injectable (levorphanol)  
         [0154]    12. Lortab (hydrocodone bitartrate/acetaminophen combo)  
         [0155]    13. Mepergan Injection (meperidine HCL/promethazine)  
         [0156]    14. MS Contin (morphine sulfate controlled-release)  
         [0157]    15. MSIR tabs/caps/solution (immediate release morphine sulfate)  
         [0158]    16. Norco Tablets (hydrocodone bitartrate/acetaminophen)  
         [0159]    17. Numorphan suppositories/injection (Oxymorphone HCL)  
         [0160]    18. Oramorph SR (morphine sulfate sustained release tablets)  
         [0161]    19. Orlaam Oral Solution (levomethadyl acetate HCL)  
         [0162]    20. OxyContin (Oxycodone HCL controlled-release tablets)  
         [0163]    21. OxyFast (oxycodone HCL immediate release concentrate solution)  
         [0164]    22. OxyIR (oxycodone HCL immediate-release capsules)  
         [0165]    23. Percocet (oxycodone/acetaminophen)  
         [0166]    24. Percodan (oxycodone/aspirin)  
         [0167]    25. Percolone (oxycodone)  
         [0168]    26. Roxanol (morphine sulfate immediate-release solution concentrate)  
         [0169]    27. Tylenol with codeine (codeine/acetaminophen)  
         [0170]    28. Tylox (oxycodone/acetaminophen)  
         [0171]    29. Vicodin (hydrocodone bitartrate/acetaminophen)  
         [0172]    30. Vicoprofen (hydrocodone/ibuprofen)  
         [0173]    31. Wygesic (propoxyphene HCL/acetaminophen)  
         [0174]    32. Zydone (hydrocodone bitartrate/acetaminophen)  
         [0175]    E. Nonsteroidal Anti-Inflammatory Agents (NSAIDS)(COX-2&#39;s)  
         [0176]    1. Anaprox (naproxen sodium)  
         [0177]    2. Arthrotec (diclofenac/misoprostol)  
         [0178]    3. Cataflam/Voltaren/Voltaren XR (diclofenac  
         [0179]    4. Celebrex (celecoxib)  
         [0180]    5. Clinoril (Sulindac)  
         [0181]    6. Daypro (oxaprozin)  
         [0182]    7. Disalcid (salsalate)  
         [0183]    8. Dolobid (Diflunidal)  
         [0184]    9. EC-Naprosyn Delayed-Reslease (naproxen)  
         [0185]    10. Feldene (piroxicam)  
         [0186]    11. Indocin (indomethacin)  
         [0187]    12. Lodine (etodolac)  
         [0188]    13. Mobic (meloxicam)  
         [0189]    14. Motrin (ibuprofen)  
         [0190]    15. Nalfon (fenoprofen calcium)  
         [0191]    16. Naprelan (naproxen sodium controlled release)  
         [0192]    17. Orudis (ketoprofen)  
         [0193]    18. Ponstel (mefenamic acid)  
         [0194]    19. Relafen (nabumetone)  
         [0195]    20. Tolectin (tolmetin sodium)  
         [0196]    21. Toradol (Ketorolac tromethamine tabs/injection)  
         [0197]    22. Trilisate (choline magnesium trisalicylate)  
         [0198]    23. Vioxx tabs/liquid (rofecoxib)  
         [0199]    Exemplary Quality Audits/Quality Letters (Analgesics):  
         [0200]    Therapeutic duplication of COX-2 Inhibitor medications;  
         [0201]    Excess dosing (beyond PDR maximum daily recommendations);  
         [0202]    Dosing Initiation Titration For Opioid Nieve patients (first time opioid);  
         [0203]    Inadequate Dosing for Continuous Chronic Pain Control;  
         [0204]    Drug/Drug Interactions (Pharmacokinetic and/or Pharmacodynamic);  
         [0205]    Cost ineffective pill strength selection;  
         [0206]    Use of two or more drugs from same chemical class (NSAIDS, narcotics);  
         [0207]    No Timely Refill (adherence);  
         [0208]    Brand versus Generic;  
         [0209]    Patient with two or more physicians;  
         [0210]    Use of narcotics For More Than Two Weeks for Non-Terminal Disease;  
         [0211]    Quantity of Pills Prescribed;  
         [0212]    Taking NSAID with Food or Cytoprotective Agent.  
       Example III.  
     Anesthetics  
       [0213]    A. General Anesthetics  
         [0214]    1. Diprivan Injectable Emulsion (propofol)  
         [0215]    2. Fluothane (halothane inhalation)  
         [0216]    3. Suprane Liquid for Inhalation (desflurane)  
         [0217]    4. Versed Injection (midazolam)  
         [0218]    B. Local Anesthetics  
         [0219]    1. Adrenalin Chloride Injection (epinephrine inhalation solution)  
         [0220]    2. Chrirocaine Injection (Levobupivacaine injection)  
         [0221]    3. Duranest Injections (etidocaine HCL)  
         [0222]    4. Naropin Injection (ropivacaine HCL injection)  
         [0223]    5. Nesacaine Injection (chloroprocaine HCL injection)  
         [0224]    6. Sarapin (salts of sarraceniacae—Pitcher Plant  
         [0225]    7. Sensorcaine Injection/with epinephrine (bupivacaine HCL)  
         [0226]    8. Xylocaine (lidocaine HCL injection)  
         [0227]    Exemplary Quality Audits/Quality Letters (Anesthetics):  
         [0228]    Inadequate Dosing;  
         [0229]    Injection Rate To Fast;  
         [0230]    Drug/Drug Interaction;  
         [0231]    Duration of analgesia for procedure;  
         [0232]    Brand versus generic;  
         [0233]    Excess Dosing Amount and Rate of Injection;  
       Example IV.  
     Anticonvulsants  
       [0234]    A. Barbiturates  
         [0235]    1. Mabaral (mephobarbital)  
         [0236]    2. Nembutal (pentobarbital)  
         [0237]    B. Benzodiazepine Anticonvulsants  
         [0238]    1. Ativan injection (lorazepam)  
         [0239]    2. Diastat Rectal Delivery System (diazepam)  
         [0240]    3. Klonopin (clonazepam)  
         [0241]    4. Tranxene T-TAB (clorazepate)  
         [0242]    5. Valium tabs/injectable (diazepam)  
         [0243]    C. GABA Analogues  
         [0244]    1. Gabitril Filmtab (Tiagabine HCL)  
         [0245]    2. Neurontin (gabapentin)  
         [0246]    D. Hydantoins  
         [0247]    1. Cerebyx Injection (Fosphenytoin sodium injection)  
         [0248]    2. Dilantin (phenytoin sodium)  
         [0249]    E. Miscellaneous Anticonvulsants  
         [0250]    1. Carbatrol (carbamazepine extended release capsules)  
         [0251]    2. Depacon Injection (Valproate sodium injection)  
         [0252]    3. Depakene (Valproic acid capsules and syrup)  
         [0253]    4. Depakote (Divalproex sodium, delayed release)  
         [0254]    5. Felbatol (felbamate)  
         [0255]    6. Keppra (levetiracetam)  
         [0256]    7. Mysoline (primidone)  
         [0257]    8. Tegretol (carbamazepine)  
         [0258]    9. Topamax (topiramate)  
         [0259]    10. Trileptal (Oxcarbazepine)  
         [0260]    11. Zonegran (zonisamide)  
         [0261]    F. Phenyltriazines  
         [0262]    1. Lamictal (lamotrigine)  
         [0263]    G. Succinimides  
         [0264]    1. Celontin (methsuximide)  
         [0265]    2. Zarontin (ethosuximide)  
         [0266]    Exemplary Quality Audits/Quality Letters (Anticonvulsants):  
         [0267]    Excess Dosing (Therapeutic Plasma level ranges);  
         [0268]    Inadequate Dosing (Therapeutic Plasma level ranges);  
         [0269]    Drug/Drug Interactions (Pharmacokinetic or Pharamcodynamic);  
         [0270]    Cost ineffective pill strength selection;  
         [0271]    No Timely refill (patient adherence);  
         [0272]    Brand versus generic;  
         [0273]    Patient with two or more physicians;  
         [0274]    Use of hypnotic anticonvulsants for greater than 2 weeks;  
         [0275]    Directions for Use: Caregiver instruction/training (Diastat).  
       Example V.  
     Oral Antidiabetics  
       [0276]    1. Glucophage (metformin)  
         [0277]    2. Glucovance (glyburide/metformin)  
         [0278]    3. Glyset (miglitol)  
         [0279]    4. Precose (acarbose)  
         [0280]    5. Insulins  
         [0281]    6. Prandin (repaglinide)  
         [0282]    7. Amaryl (glimepiride)  
         [0283]    8. DiaBeta (glyburide)  
         [0284]    9. Diabinese (chlorpropamide)  
         [0285]    10. Glucotrol (glipizide)  
         [0286]    11. Glocovance (glyburide and metformin)  
         [0287]    12. Actos (pioglitazone)  
         [0288]    13. Avandia (rosiglitazone)  
         [0289]    Exemplary Quality Audits/Quality Letters:  
         [0290]    Excess Dosing (Beyond PDR Recommended daily max);  
         [0291]    Therapeutic Duplications of oral antidiabetics in same family;  
         [0292]    Inadequate Dosing;  
         [0293]    Drug/Drug Interactions;  
         [0294]    Cost ineffective pill strength selection;  
         [0295]    No timely refills (patient adherence);  
         [0296]    Brand versus generic;  
         [0297]    Patient with two or more physicians;  
       Example VI.  
     Anti-Infective Agents  
       [0298]    A. AIDS Therapy  
         [0299]    1. Reverse Transcriptase Inhibitors  
         [0300]    a. Rescriptor (delavirdine mesylate)  
         [0301]    b. Sustiva (efavirenz)  
         [0302]    c. Viramune (nevirapine)  
         [0303]    2. Nucleoside reverse transcriptase inhibitors  
         [0304]    a. Combivir  
         [0305]    b. Epivir  
         [0306]    c. Hivid  
         [0307]    d. Retrovir  
         [0308]    e. Videx  
         [0309]    f. Zerit  
         [0310]    g. Ziagen  
         [0311]    3. Protease Inhibitors  
         [0312]    a. Agenerase  
         [0313]    b. Crixivan  
         [0314]    c. Fortovase  
         [0315]    d. Invirase  
         [0316]    e. Norvir  
         [0317]    f. Vriacept  
         [0318]    Exemplary Quality Audits/Quality Letters (AIDS Therapy):  
         [0319]    Therapeutic Duplication of Non-Nucleoside Reverse Transcriptase;  
         [0320]    Inhibitors, Nucleoside Reverse Transcriptase Inhibitors, or Protease Inhibitors;  
         [0321]    Doses Beyond PDR Recommended Daily Maximum;  
         [0322]    Dosing Below PDR Recommended Dose for Efficacy;  
         [0323]    Drug/Drug Interactions (especially pharmacokinetic);  
         [0324]    Cost Ineffective Pill Strength Selection;  
         [0325]    Use of Two or More Drugs From the Same Chemical Class;  
         [0326]    No Timely refill (patient adherence);  
         [0327]    Patient with two or more physicians.  
         [0328]    B. Antibiotics  
         [0329]    1. Cephalosporins  
         [0330]    a. Ceclor  
         [0331]    b. Cedax  
         [0332]    c. Ceftin  
         [0333]    d. Cefzil  
         [0334]    e. Ceptaz  
         [0335]    f. Duricef  
         [0336]    g. Keflex  
         [0337]    h. Maxipime  
         [0338]    i. Suprax  
         [0339]    j. Zinacef  
         [0340]    2. Macrolides  
         [0341]    a. Biaxin  
         [0342]    b. Dynatab  
         [0343]    c. E.E.S.  
         [0344]    d. Zithromax  
         [0345]    3. Penicillins  
         [0346]    a. Amoxil  
         [0347]    b. Augmentin  
         [0348]    c. Bicillin  
         [0349]    d. Geocillin  
         [0350]    4. Tetracyclines  
         [0351]    a. Doryx  
         [0352]    b. Achromycin V  
         [0353]    c. Vibramycin  
         [0354]    5. Quinolones  
         [0355]    a. Cipro  
         [0356]    b. Floxin  
         [0357]    c. Levaquin  
         [0358]    d. Maxaquin  
         [0359]    e. NegGram  
         [0360]    f. Tequin  
         [0361]    g. Trovan  
         [0362]    h. Zagam  
         [0363]    6. Antifungals  
         [0364]    a. Diflucan  
         [0365]    b. Grifulvin V  
         [0366]    c. Lamisil  
         [0367]    d. Nizoral  
         [0368]    e. Sporanox  
         [0369]    Exemplary Quality Audit/Quality Letters (Antibiotics):  
         [0370]    Therapeutic duplication of antibiotics;  
         [0371]    Food Drug Interactions;  
         [0372]    Drug/Drug Interactions (pharmacokinetic);  
         [0373]    Pill Quantity Prescribed (Adequate length of therapy);  
         [0374]    Over utilization of antibiotics;  
         [0375]    Dosing Above the PDR Recommended Daily Maximum;  
         [0376]    Dosing below the PDR Recommended Daily Effective amount;  
         [0377]    Cost ineffective pill strength selection;  
         [0378]    Brand versus generic;  
         [0379]    Patient with two of more physicians.  
       Example VII.  
     Antiparkinsonin Agents  
       [0380]    Akineton  
         [0381]    Artane  
         [0382]    Comtan (entacapone)  
         [0383]    Tasmar  
         [0384]    Eldepryl  
         [0385]    Levsin  
         [0386]    Mirapex (pramipexole)  
         [0387]    Permax (pergolide mesylate)  
         [0388]    Requip (ropinirole HCL)  
         [0389]    Sinemet  
         [0390]    Symmetrel  
         [0391]    Exemplary Quality Audit/Quality Letters (Antiparkinsonian Drugs):  
         [0392]    Therapeutic duplications of anticholinergics, or dopamine agonists;  
         [0393]    Dosing Initiation and Titration of dopamine agonists;  
         [0394]    Dosing Above the PDR Recommended Maximum Daily Amount;  
         [0395]    Dosing Below the PDR Recommended Effective Minimal Dose;  
         [0396]    Drug/Drug Interactions (Pharmacokinetic and/or pharmacodynamic);  
         [0397]    Cost ineffective Pill Strength Selection;  
         [0398]    No Timely Refills (patient adherence);  
         [0399]    Brand versus generic;  
         [0400]    Patient with two or more physicians.  
       Example VIII.  
     Biological Response Modifiers  
       [0401]    Avonex  
         [0402]    Betaseron  
         [0403]    Intron A  
         [0404]    Neupogen (filgrastim)  
         [0405]    Prolukin  
         [0406]    Rebetron  
         [0407]    Remicade  
         [0408]    Roferon-A  
         [0409]    Exemplary Quality Audits/Quality Letters (Biological Response Modifiers):  
         [0410]    Appropriate patient selection;  
         [0411]    Dosing Initiation and Titration;  
         [0412]    Timing of drug initiation in relation to cytotoxic chemotherapy;  
         [0413]    Dosing Above the PDR Recommended Daily Maximum;  
         [0414]    Drug/Drug Interactions;  
         [0415]    Maximal Efficacy by Combining with PDR recommend drug.  
       Example IX.  
     Biologicals  
       [0416]    Immume Serums  
         [0417]    BayGam  
         [0418]    BayHep B  
         [0419]    CytoGam IV  
         [0420]    Gamimune N  
         [0421]    RhoGAM  
         [0422]    Sandoglobulin IV  
         [0423]    Vaccines  
         [0424]    Fluogen  
         [0425]    Fluzone  
         [0426]    Havrix  
         [0427]    Exemplary Quality Audits/Quality Letters (Biologicals):  
         [0428]    Appropriate patient selection;  
         [0429]    Dosing initiation and titration;  
         [0430]    Timing of initiation of drug relative to symptoms.  
       Example X.  
     Cardiovasculars  
       [0431]    ACE Inhibitors  
         [0432]    Accupril  
         [0433]    Aceon  
         [0434]    Altace  
         [0435]    Captopril  
         [0436]    Lotensin  
         [0437]    Mavik  
         [0438]    Monopril  
         [0439]    Prinivil  
         [0440]    Univasc  
         [0441]    Vasotec  
         [0442]    Zestril  
         [0443]    ACE II Receptor Antagonists  
         [0444]    Atacand  
         [0445]    Avapro  
         [0446]    Cozaar  
         [0447]    Diovan  
         [0448]    Micardis  
         [0449]    Teveten  
         [0450]    Exemplary Quality Audits/Quality Letters (ACE Receptor Antagonists):  
         [0451]    Therapeutic duplication of ACE Inhibitor or ACE II Inhibitors;  
         [0452]    Dosing Beyond the PDR Maximum Daily Dose;  
         [0453]    Dosing Below the PDR Effective Minimal Dose for Efficacy;  
         [0454]    Drug/Drug Interaction (pharmacokinetic);  
         [0455]    Cost ineffective pill strength selection;  
         [0456]    Use of two or more drugs from the same chemical class;  
         [0457]    No timely refill (patient adherence);  
         [0458]    Brand versus generic;  
         [0459]    Patient with two or more physicians.  
       Example XI.  
     Antiarrhythymics  
       [0460]    Mexitil  
         [0461]    Norpace  
         [0462]    Procainbid  
         [0463]    Quinaglute  
         [0464]    Quinidex  
         [0465]    Tambocor  
         [0466]    Tonocard  
         [0467]    Betapace  
         [0468]    Inderal LA  
         [0469]    Cordarone  
         [0470]    Calan  
         [0471]    Cardizem  
         [0472]    Exemplary Quality Audits/Quality Letters (Antiarrhythymics):  
         [0473]    Therapeutic duplication of two or more antiarrhythymics;  
         [0474]    Dosing beyond the PDR recommended daily maximum dose;  
         [0475]    Dosing below the PDR recommended minimal effective daily dose;  
         [0476]    Drug/Drug interaction (pharmacokinetic);  
         [0477]    No timely refills (patient adherence);  
         [0478]    Brand versus generic;  
         [0479]    Patient with two or more physicians;  
         [0480]    Instructing patient to break a controlled release formulation unit;  
       Example XII.  
     HMG-CoA Reductase Inhibitors  
       [0481]    Baycol  
         [0482]    Lescol  
         [0483]    Lipitor  
         [0484]    Mevacor  
         [0485]    Pravachol  
         [0486]    Zocor  
         [0487]    Exemplary Quality Audits/Quality Letters (HMG-COA Reductase Inhibitors):  
         [0488]    Therapeutic duplications of HMG-CoA Reductase Inhibitors;  
         [0489]    Dosing above the PDR recommended daily maximum dose;  
         [0490]    Dosing below the PDR recommended daily minimal effective dose;  
         [0491]    Drug/Drug Interactions (Pharmacokinetic);  
         [0492]    Cost ineffective pill strength selection;  
         [0493]    No timely refills (patient adherence);  
         [0494]    Brand versus Generic;  
         [0495]    Patient with two or more physicians.  
       Example XIII.  
     Beta Adrenergic Blocking Agents  
       [0496]    Betapace  
         [0497]    Blocadren  
         [0498]    Cartrol Filmtab  
         [0499]    Inderal LA  
         [0500]    Kerlone  
         [0501]    Nadolol  
         [0502]    Sectral  
         [0503]    Tenormin  
         [0504]    Toprol XL  
         [0505]    Zebeta  
         [0506]    Exemplary Quality Audits/Quality Letters (Beta Blockers):  
         [0507]    Therapeutic duplication of beta blockers;  
         [0508]    Combination of a beta-1 selective beta blocker with a nonselective agent;  
         [0509]    Dosing about the PDR recommended daily maximum dose;  
         [0510]    Dosing below the PDR recommended daily minimal effective dose;  
         [0511]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0512]    Cost ineffective pill strength selection;  
         [0513]    No timely refills (patient adherence);  
         [0514]    Brand versus generic;  
         [0515]    Patient with two or more physicians;  
         [0516]    Splitting sustained release formulations.  
       Example XIV.  
     Calcium Channel Blockers  
       [0517]    Adalat  
         [0518]    Calan  
         [0519]    Calan SR  
         [0520]    Cardizem CD  
         [0521]    Covera—HS  
         [0522]    Isoptin SR  
         [0523]    Nimotop  
         [0524]    Norvasc  
         [0525]    Plendil  
         [0526]    Procardia XL  
         [0527]    Sular  
         [0528]    Tiazac  
         [0529]    Vascor  
         [0530]    Verelan  
         [0531]    Exemplary Quality Audits/Quality Letters (Calcium Channel Blockers):  
         [0532]    Therapeutic duplication of two or more calcium channel blockers;  
         [0533]    Dosing above the PDR recommended daily maximum dose;  
         [0534]    Dosing below the PDR recommended daily minimal effective dose;  
         [0535]    Drug/Drug interactions (pharmacokinetic or pharmacodynamic);  
         [0536]    Splitting sustained release formulations;  
         [0537]    Cost ineffective pill strength selection;  
         [0538]    No timely refills (patient adherence);  
         [0539]    Brand versus generic;  
         [0540]    Patient with two or more physicians.  
       Example XV.  
     Miscellaneous Cardiovascular Agents/Fibrin-Specific Thrombolytic Agents  
       [0541]    Activase IV (Alteplase)  
         [0542]    Retavase (Retaplase)  
         [0543]    TNKase (Tenecteplase)  
         [0544]    Demser (Metyrosine)  
         [0545]    Inversine  
         [0546]    ReoPro  
         [0547]    Streptase for infusion  
         [0548]    Exemplary Quality Audits/Quality Letters (Miscellaneous CV Agents):  
         [0549]    Appropriate patient selection;  
         [0550]    Initiation of drug soon enough after the event for it to be effective;  
         [0551]    Dose above the mg/kg recommendations in the PDR;  
         [0552]    Injected within the PDR recommended time period (bolus/infusion length);  
         [0553]    Drug/Drug interactions (pharmacokinetic and pharmacodynamic);  
         [0554]    Patient instructions regarding adequate water intake with Demser;  
         [0555]    Dosing below the PDR recommended optimally effective daily dose;  
         [0556]    Contraindicated in acute MI patients at increased risk of bleeding (fibrin-specific thrombolytic agents).  
       Example XVI.  
     Vasodilators  
       [0557]    Imdur  
         [0558]    Ismo (isosorbide mononitrate)  
         [0559]    Isordil sublingual  
         [0560]    Nitro-Dur Transdermal Systems  
         [0561]    Nitrolingual Pumpspray  
         [0562]    Nitrostat tablets  
         [0563]    Exemplary Quality Audits/Quality Letters (Vasodilators):  
         [0564]    Therapeutic duplication of vasodilators;  
         [0565]    Correct dosing interval between doses;  
         [0566]    Dosing above the PDR recommended daily maximum dose;  
         [0567]    Dosing below the PDR recommended optimally effective daily dose;  
         [0568]    Cost ineffective pill strength selection;  
         [0569]    No timely refills (patient adherence);  
         [0570]    Brand versus generic;  
         [0571]    Patient with two or more physicians;  
         [0572]    Patient instructions for use of transdermal patches;  
         [0573]    Repackaging of nitroglycerin tablets.  
       Example XVII.  
     CNS Stimulants (for ADHD/Other)  
       [0574]    Amphetamines  
         [0575]    Adderall  
         [0576]    Desoxyn  
         [0577]    Dexedrine Spansule  
         [0578]    Dexedrine Tablets  
         [0579]    DextroStat Tablets  
         [0580]    Miscellaneous CNS Stimulants  
         [0581]    Concerta  
         [0582]    Cylert  
         [0583]    Dopram  
         [0584]    Medadate ER  
         [0585]    Methylin ER  
         [0586]    Provigil  
         [0587]    Ritalin IR/SR  
         [0588]    Exemplary Quality Audits/Quality Letters (Stimulants):  
         [0589]    Therapeutic duplications of psychostimulants;  
         [0590]    Dosing above the PDR recommended daily maximum dose;  
         [0591]    Drug/Drug Interactions (pharmacokinetic and pharmacodynamic);  
         [0592]    Cost ineffective pill strength selection;  
         [0593]    Brand versus generic;  
         [0594]    Patient with two or more physicians;  
       Example XVIII.  
     Erectile Dysfunction (ED) Therapy  
       [0595]    Viagra  
         [0596]    Exemplary Quality Audits/Quality Letters (ED Drugs):  
         [0597]    Drug/Drug interactions: (pharmacokinetic/pharmacodynamic);  
         [0598]    Contraindication with nitrates (inhaled or oral);  
         [0599]    Patient with two or more physicians;  
         [0600]    Prescription of large quantity of tablets per Rx (i.e. over tablets per Prescription);  
       Example XIX.  
     Gastrointestinal Agents  
       [0601]    Antiemetics  
         [0602]    Anzemet (dolasetron mesylate) tablets  
         [0603]    Kytril injection  
         [0604]    Marinol  
         [0605]    Reglan  
         [0606]    Transderm Scop Transdermal System  
         [0607]    Zofran Tablets/injection  
         [0608]    Exemplary Quality Audit/Quality Letters (Antiemitics):  
         [0609]    Therapeutic duplication of 5-HT3 blockers;  
         [0610]    Dosing above the PDR recommended daily maximum dose;  
         [0611]    Dosing below the PDR recommended optimally effective daily dose;  
         [0612]    Drug/Drug Interactions (pharmacokinetic and pharmacodynamic);  
         [0613]    Cost ineffective pill strength selection;  
         [0614]    Brand versus generic;  
         [0615]    Patient with two or more physicians;  
         [0616]    Prescription of large quantity of 5-HT3 blockers per Rx (i.e. over 30 Tablets per prescription).  
       Example XX.  
     Anti-Inflammatory Agents (IBS, Chron&#39;s, Ulcerative Colitis)  
       [0617]    Asacol Delayed-Release  
         [0618]    Azulfadine EN tablets (sulfasalazine delayed release tablets)  
         [0619]    Colazal capsules  
         [0620]    Dipentum capsules (olsalazine sodium capsules)  
         [0621]    Pentasa capsules (mesalamine controlled release)  
         [0622]    Exemplary Quality Audit/Quality Letters (Irritable Bowl Syndrome/Chron&#39;s):  
         [0623]    Therapeutic duplication of IBS/Chron&#39;s Drugs in same chemical class;  
         [0624]    Dosing above the PDR recommended daily maximum dose;  
         [0625]    Dosing below the PDR Recommended optimally effective dose;  
         [0626]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0627]    Cost ineffective pill strength selection;  
         [0628]    No timely refills (patient adherence);  
         [0629]    Brand versus generic;  
         [0630]    Patient with two or more physicians;  
         [0631]    Splitting sustained release formulations;  
       Example XXI.  
     Doudenal Ulcer Adherent Complex  
       [0632]    Carafate tables/suspension  
         [0633]    Exemplary Quality Audit/Quality Letters (Adherent Complex Drugs):  
         [0634]    Therapeutic duplication with other adherent complex drugs;  
         [0635]    Instructions to take on empty stomach;  
         [0636]    Instructions to administer carafate 2 hours after other medications;  
         [0637]    Daily Use beyond 8 weeks (If used longer than 8 weeks, reduce dose to 1 g BID);  
         [0638]    Drug/Drug Interactions (pharmacokinetic and pharmacodynamic);  
         [0639]    Dosing above PDR recommended daily maximal dose;  
         [0640]    Dosing below PDR recommended optimally effective daily dose;  
         [0641]    Brand versus generic;  
         [0642]    Patient with two or more physicians.  
       Example XXII.  
     Histamine (H2) Receptor Antagonists  
       [0643]    Axid  
         [0644]    Pepcid  
         [0645]    Tagamet  
         [0646]    Zantac  
         [0647]    Proton Pump Inhibitors  
         [0648]    Aciphex tablets  
         [0649]    Prevacid Delayed-Release Capsules  
         [0650]    Prilosec Delayed-Release Capsules  
         [0651]    Protonix  
         [0652]    Exemplary Quality Audit/Quality Letters (H2 Blockers and Proton Pump Inhibitors):  
         [0653]    Therapeutic duplications of H2 blockers;  
         [0654]    Therapeutic duplications of proton pump inhibitors;  
         [0655]    Dosing above PDR recommended daily maximal dose;  
         [0656]    Dosing below PDR recommended optimally effective dose;  
         [0657]    Brand versus generic;  
         [0658]    Patient with two or more physicians;  
         [0659]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0660]    Cost ineffective pill strength selection;  
         [0661]    Patient with two or more physicians;  
         [0662]    No timely refills (patient adherence).  
       Example XXIII.  
     Migraine Preparations  
       [0663]    Serotonin (5-HT) Receptor Agonists  
         [0664]    Amerge (naratriptan)  
         [0665]    Imitrex  
         [0666]    Maxalt (rizatriptan benzoate)  
         [0667]    Zomig (zolmitriptan)  
         [0668]    Exemplary Quality Audit/Quality Letters (Serotonin Receptor Agonists):  
         [0669]    Therapeutic duplication of 5-HT receptor agonists for migraine;  
         [0670]    Dosing above the PDR recommended daily maximal dose;  
         [0671]    Dosing below the PDR recommended optimally effective dose;  
         [0672]    Brand versus generic;  
         [0673]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0674]    Cost ineffective pill strength selection;  
         [0675]    Patient with two or more physicians;  
         [0676]    Quantity of pills prescribed per Rx (i.e. not over 10 pills);  
         [0677]    Patient information/instruction on use;  
         [0678]    Not for patients with ischemic heart disease, history of MI, or uncontrolled Hypertension;  
         [0679]    Not to be used with MAO inhibitors or within 2 weeks of discontinuation of MAO inhibitors.  
       Example XXIV.  
     Obesity Management  
       [0680]    Appetite Suppressants  
         [0681]    Adipex-P  
         [0682]    Bontril Slow-Release Capsules  
         [0683]    Desoxyn Tablets  
         [0684]    Ionamin capsules  
         [0685]    Meridia capsules  
         [0686]    Lipase Inhibitors  
         [0687]    Xenical capsules  
         [0688]    Exemplary Quality Audit/Quality Letters (Obeisty):  
         [0689]    Therapeutic duplications of stimulant antiobesity drugs;  
         [0690]    Dosing above the PDR recommended daily maximal dose;  
         [0691]    Dosing below the PDR recommended optimally effective daily dose;  
         [0692]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0693]    Cost ineffective pill strength selection;  
         [0694]    Adequate patient instructions;  
         [0695]    Brand versus generic;  
         [0696]    Patient with two or more physicians.  
       Example XXV.  
     Psychotherapeutic Agents (Behavioral Pharmacy Medications)  
       [0697]    Antianxiety Agents/Benzodiazepines and Combinations  
         [0698]    Ativan  
         [0699]    Librium  
         [0700]    Limbitrol  
         [0701]    Tranxene  
         [0702]    Valium  
         [0703]    Xanax  
         [0704]    Azapirones  
         [0705]    Buspar (buspirone)  
         [0706]    Miscellaneous Antianxiety Agents  
         [0707]    Atarax  
         [0708]    Effexor XR  
         [0709]    Mebaral tablets  
         [0710]    Miltown  
         [0711]    Paxil  
         [0712]    Sinequan  
         [0713]    Vistaril  
         [0714]    Antidepressants  
         [0715]    Effexor/Effexor XR  
         [0716]    Remeron  
         [0717]    Serzone  
         [0718]    Wellutrin/Wellbutrin SR  
         [0719]    Celexa  
         [0720]    Paxil  
         [0721]    Prozac/Sarafem  
         [0722]    Zoloft  
         [0723]    Luvox  
         [0724]    Elavil injection  
         [0725]    Elavil tablets  
         [0726]    Etrafon 2-10  
         [0727]    Limbitrol  
         [0728]    Norpramin  
         [0729]    Sinequan  
         [0730]    Surmontil  
         [0731]    Vivactil  
         [0732]    Antimanic  
         [0733]    Depakote  
         [0734]    Eskalith  
         [0735]    Eskalith CR  
         [0736]    Lithium carbonate  
         [0737]    Lithobid  
         [0738]    Antipanic  
         [0739]    Klonopin tablets  
         [0740]    Paxil tablets/suspension  
         [0741]    Xanax  
         [0742]    Zoloft tablets/concentrate  
         [0743]    Antipsychotics: Atypicals  
         [0744]    Abilitat  
         [0745]    Clozaril  
         [0746]    Risperdal  
         [0747]    Seroquel  
         [0748]    Zyprexa  
         [0749]    Zyprexa ZYDIS  
         [0750]    Ziprasidone  
         [0751]    Antipsychotics: Typical  
         [0752]    Compazine  
         [0753]    Serentil  
         [0754]    Stelazine  
         [0755]    Mellaril  
         [0756]    Thorazine  
         [0757]    Haldol/Haldol Decanoate  
         [0758]    Loxitane  
         [0759]    Moban  
         [0760]    Navane  
         [0761]    Orap  
         [0762]    Sedative/Hypnotics (Non-Benzodiazepine)  
         [0763]    Ambien  
         [0764]    Sonata  
         [0765]    Exemplary Quality Audit/Quality Letters (Psychtropics-Behavioral Drugs):  
         [0766]    Therapeutic duplications of atypical antipsychotics;  
         [0767]    Dosing above the PDR recommended maximal daily amount;  
         [0768]    Dosing below the PDR recommended optimally effective dose;  
         [0769]    Drug/Drug interactions (pharmacokinetic or pharmacodynamic);  
         [0770]    Cost ineffective pill strength selection;  
         [0771]    Use of two or more drugs from the same chemical class;  
         [0772]    No timely refills (patients adherence);  
         [0773]    Brand versus generic;  
         [0774]    Patient with two or more physicians;  
         [0775]    Use of sedative/hypnotics for greater than 30 days;  
         [0776]    SSRIs, Serzone, Effexor, Remeron, Wellbutrin, Zyban used in combination with MAOIs.  
       Example XXVI.  
     Respiratory Agents  
       [0777]    Steroidal Anti-inflammatory Agents  
         [0778]    Aerobid Inhaler system  
         [0779]    Azmacort Inhalation  
         [0780]    Beclovent Inhalation  
         [0781]    Flovent  
         [0782]    Pulmicort  
         [0783]    Vanceril  
         [0784]    Bronchodilators  
         [0785]    Atrovent Aerosol and Solution  
         [0786]    Combivent Aerosol  
         [0787]    Alupent  
         [0788]    Brethine  
         [0789]    Maxair  
         [0790]    Proventil  
         [0791]    Rynatuss  
         [0792]    Serevent Diskus  
         [0793]    Ventolin  
         [0794]    Volmax ER tablets  
         [0795]    Xopenex Inhalation Solution (levalbuterol)  
         [0796]    Aerolate capsules/liquid  
         [0797]    Cafcit  
         [0798]    Lufyllin  
         [0799]    Theo-24 Extended Release Capsules  
         [0800]    Theo-Dur Extended Release Capsules  
         [0801]    Uni-Dur  
         [0802]    Uniphyl  
         [0803]    Decongenstants/Allergy  
         [0804]    Allegra-D Extended Release  
         [0805]    Alumadrine tablets  
         [0806]    Bronfed capsules  
         [0807]    Claritin and Claritin-D  
         [0808]    Accolate tablets  
         [0809]    Singulair tablets  
         [0810]    Zyrtec tablets/syrup  
         [0811]    Exemplary Quality Audit/Quality Letters (Respiratory Drugs):  
         [0812]    Therapeutic duplications of theophylline products;  
         [0813]    Therapeutic duplications of inhaled bronchodilators;  
         [0814]    Therapeutic duplications of inhaled steroidal intiinflamatory agents;  
         [0815]    Therapeutic duplications of non-sedating allergy drugs;  
         [0816]    Dosing above the PDR recommended daily maximal dose;  
         [0817]    Dosing below the PDR recommended daily optimally effective dose;  
         [0818]    Drug/Drug Interactions (pharmacokinetic/pharmacodynamic);  
         [0819]    Instructions for patients on use of inhaler devices;  
         [0820]    Cost ineffective pill strength selection;  
         [0821]    No timely refills (patient adherence);  
         [0822]    Brand versus generic;  
         [0823]    Patient with two or more physicians.  
       Example XXVII.  
     Smoking Cessation Aids  
       [0824]    Nicoderm CQ  
         [0825]    Nicorette Gum  
         [0826]    Nicotrol Inhaler  
         [0827]    Nicotrol Nasal Spray  
         [0828]    Nicotrol Patch  
         [0829]    Zyban SR Tablets (bupropion)  
         [0830]    Exemplary Quality Audit/Quality Letters (Smoking Cessation Aids):  
         [0831]    Therapeutic duplications of nicotine replacement products;  
         [0832]    Dosing Initiation and Titration process;  
         [0833]    Length of use beyond six months for nicotine products; Use of Zyban for smoking cessation beyond 4 months;  
         [0834]    Patient instruction for when to stop smoking in relation to starting Zyban;  
         [0835]    Use of MAO Inhibitors with Zyban;  
         [0836]    Patient with two or more physicians;  
         [0837]    Drug/Drug interaction (pharmacokinetic/pharmacodynamic);  
         [0838]    Dosing above PDR recommended maximal daily doses;  
         [0839]    Dosing below PDR recommended daily optimally effective doses.  
       Example XXIX.  
     Urinary Tract Agents: (BPH)  
       [0840]    Cardura Tablets  
         [0841]    Flomax capsules  
         [0842]    Hytrin  
         [0843]    Proscar (finasteride)  
         [0844]    Exemplary Quality Audits/Quality Letters (BPH Drugs):  
         [0845]    Therapeutic duplications of BPH drugs with same mechanism;  
         [0846]    Dosing above PDR recommended daily maximal doses;  
         [0847]    Dosing below PDR recommended daily minimally effective doses;  
         [0848]    Drug/Drug interactions (pharmacokinetic/pharmacodynamic);  
         [0849]    Cost ineffective pill strength selection;  
         [0850]    Brand versus generic;  
         [0851]    No timely refill (patient adherence);  
         [0852]    Patient with two or more physicians.  
         [0853]    While the present invention has been described with respect to a selected embodiment thereof, it will be appreciated by those skilled in the art that various modifications and variations of the invention are possible with departing from the spirit and scope of the appended claims.