Abstract:
Gene expression patterns contemporaneous with early placental development in the first trimester of preeclamptic versus unaffected pregnancies have been obtained. Observation of differences in these gene expression patterns has allowed the identification of biomarkers that are useful in predicting and monitoring preeclampsia. These biomarkers are also useful in screening potential therapeutics for efficacy in the prevention or treatment of preeclampsia.

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
       [0001]    This application claims the benefit of U.S. Provisional Application Ser. No. 61/097,356, filed Sep. 16, 2008, the disclosure of which is hereby incorporated by reference in its entireties, including all figures, tables and amino acid or nucleic acid sequences. 
     
    
     GOVERNMENT SUPPORT 
       [0002]    The subject matter of this application has been supported by the Center for Research and Evaluation Faculty Research Funds of the University of Pittsburgh School of Nursing, the American Nurses Foundation, the NIH/NINR Summer Genetics Institute, and grant number NIH PO1 HL30367 Subproject #2. Accordingly, the government has certain rights in this invention. 
     
    
     BACKGROUND OF THE INVENTION 
       [0003]    Preeclampsia (Online Mendelian Inheritance in Man [OMIM] 189800) is a pregnancy-specific disorder that leads among the causes of maternal and infant morbidity and mortality worldwide. Occurring in 4 to 8% of all pregnancies, (Ilekis et al., 2007; ACOG Publication 2002) this multi-systemic disorder contributes to 20% of maternal deaths in the United States alone (Christiansen et al., 2006). Infants are at increased risk of growth restriction and the adverse effects of indicated preterm delivery, which is the only definitive treatment for preeclampsia (Stella et al., 2006). Further burden is imposed by increased risk of cardiovascular disease later in life for women and offspring who survive preeclampsia (Roberts et al., 2003; Sibai et al., 2005). 
         [0004]    Prevention, early detection, and specific treatment of preeclampsia are hindered by the fact that the etiology has remained unknown (Sibai et al., 2005). Current consensus implicates placental and endothelial dysfunction, inflammation and genetics in development of preeclampsia (Ilekis et al., 2007; Mohaupt 2007; Nishizawa et al., 2007). Extravillous trophoblasts in preeclamptic pregnancies fail to adequately remodel the maternal uterine spiral arteries, thereby compromising blood flow to the placenta (Ilekis et al., 2007). This alteration reduces placental oxygen and nutrient supply, creating ischemia-hypoxia and oxidative stress associated with reperfusion injury (Khong et al., 1986). This placental pathology leads to the elaboration of a variety of injurious agents into the maternal circulation producing excessive maternal systemic inflammation (Redman et al., 1999) and endothelial dysfunction, and results in potentially lethal sequelae, such as eclamptic seizure, stroke, pulmonary edema, renal failure and hemorrhage (Roberts et al., 1993; Roberts et al., 2002). 
         [0005]    A better understanding of the early pathophysiology at the molecular level has been needed. Because preeclampsia resolves with removal of the placenta, (Roberts et al. 2001) microarray studies have been conducted with second and third trimester placental tissue after delivery, in order to examine organ-specific, global genomic variations associated with preeclampsia (Founds et al., 2008). Despite these efforts, the etiology has been elusive because prior microarray analyses in preeclampsia interrogated placentas after disease onset in later gestation, thereby precluding differentiation of cause and effect (Chappell et al., 2006). In contrast, the present invention relates to gene expression patterns early in the course of placental development. 
       BRIEF SUMMARY OF THE INVENTION 
       [0006]    Gene expression patterns contemporaneous with early placental development in the first trimester of preeclamptic versus unaffected pregnancies have been obtained. Observation of differences in these gene expression patterns has allowed the identification of biomarkers that are useful in predicting and monitoring preeclampsia. These biomarkers are also useful in screening potential therapeutics for efficacy in the prevention or treatment of preeclampsia. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0007]      FIGS. 1A-1C  relate to IPA Networks 1 and 2 involving the 36 genes of interest. The IPA graphics represent genes and potential relationships arranged by cellular compartments.  FIG. 1A . Network 1 includes 10 genes from this study related to Cancer, Respiratory Disease, and Cellular Movement.  FIG. 1B . Network 2 includes 7 genes from this study related to Inflammatory Disease, Cellular Movement, and Hematological System Development and Function.  FIG. 1C . A legend for the IPA Networks of  FIGS. 1A and 1B  gives meaning of node type symbols and edge type relationships. Dark gray filled symbols represent up-regulated genes of interest from this study. Light gray filled symbols represent down-regulated genes of interest from this study. Unfilled symbols are genes putatively involved in the pathway based on current animal and human studies. 
           [0008]      FIGS. 2A-2B . Scatterplots of Perfect Matches only, both with and without case #147.  FIG. 2A  represents perfect match data with case #147 included.  FIG. 2B  represents perfect match data with case #147 excluded. 
           [0009]      FIG. 3 . Plots comparing PM-Only J5, Pooled Variance t, Fold-Change and Random. Efficiency analysis plot comparing the observed overlap at each level of N3 for the PM-alone, untransformed data. 
           [0010]      FIG. 4 . Naïve Bayes&#39; prediction models&#39; performance. ACE (achieved classification error; =1-accuracy) plot of the performance of Naïve Bayes models with and without sample #147. J5 score is the threshold (cut-off) of the J5 test. 
       
    
    
     BRIEF DESCRIPTION OF THE TABLES 
       [0011]    Tables 1A-1C. Clinical characteristics of total microarray study sample. 
         [0012]    Table 2. Genes differentially expressed in first trimester PE: J5 analysis for CVS microarray. 
         [0013]    Table 3. Top Functions and Diseases in IPA associated with high priority genes of interest. 
         [0014]    Table 4. Functional groups other than immune incorporating IPA-omitted high priority genes of interest in PE. 
         [0015]    Table 5. Genes differentially expressed in first trimester PE: Fold change data for CVS microarray. 
         [0016]    Table 6. Hypoxia-regulated genes. 
         [0017]    Table 7. Putative HIF-2α regulated genes. 
         [0018]    Table 8. J5 and Fold Change Genes that Secrete Proteins into Blood (certain genes have both fold change and J5 values (bold)). 
         [0019]    Table 9. Genes differentially expressed in first trimester PE. 
       DETAILED DESCRIPTION OF THE INVENTION 
       [0020]    In a first aspect, the present invention relates to a method for diagnosing, monitoring, or predicting preeclampsia in a pregnant woman. This method comprises the following steps: 
         [0021]    first, quantitatively determining the amount of one or more nucleic acid species in a biological sample obtained from the pregnant woman that hybridize with probe set ID Nos: 205827_at; 215141_at; 202917_s_at; 215733_x_at; 234601_x_at; 227238_at; 239010_at; 214702_at;  1553319 _at; 235592_at; 229839_at; 230748_at; 203789_s_at; 226482_s_at; 215388_s_at; 1562053_at; 219911_s_at; 209351_at; 1552858_at; 215108_x_at; 226403_at; 207607_at; 228293_at; 210251_s_at; 1561318_at; 241036_at; 219759_at; 203592_s_at; 205302_at; 1568554_x_at; 1554276_at; 242842_at; 242868_at; 206859_s_at; 204580_at; and 207509_s_at or those set forth in Table 5 on the AFFYMETRIX GeneChip system (Affymetrix, Santa Clara, Calif.; HG-U133 Plus 2.0 GeneChips containing 53,613 probe sets); 
         [0022]    second, comparing the amount of the nucleic acid species from the first step to a standard control representing the amount of the nucleic acid species in the corresponding sample from an average non-preeclamptic pregnant woman; wherein an increase and decrease in the amount of the nucleic acid species in the test sample as compared to the standard control indicates preeclampsia or an increased risk of developing preeclampsia. The biological sample is blood, washing from the reproductive tract, urine, saliva, amniotic fluid, or chorionic villus. One aspect of the invention provides for increased expression of nucleic acids that hybridize with 205827_at; 215141_at; 202917_s_at; 215733_x_at; 234601_x_at; and decreased expression of nucleic acids that hybridize with 227238_at; 239010_at; 214702_at; 1553319_at; 235592_at; 229839_at; 230748_at; 203789_s_at; 226482_s_at; 215388_s_at: 1562053_at; 219911_s_at: 209351_at; 1552858_at; 215108_x_at; 226403_at; 207607_at; 228293_at; 210251_s_at; 1561318_at; 241036_at; 219759_at; 203592_s_at; 205302_at; 1568554_x_at; 1554276_at; 242842_at; 242868_at; 206859_s_at; 204580_at; and 207509_s_at. 
         [0023]    In some embodiments, the first step can comprise the use of a reverse transcriptase polymerase chain reaction (RT-PCR). In other embodiments, the first step comprises using a polynucleotide hybridization method, or using a primer extension reaction. 
         [0024]    Various other embodiments provide a kit for diagnosing, monitoring, or predicting preeclampsia in a pregnant woman. This kit comprises the following: (i) PCR primers for quantitatively determining the amount of one or more nucleic acid species in a biological sample obtained from the pregnant woman, wherein the nucleic acid species hybridize with probe set ID Nos: 205827_at; 215141_at; 202917_s_at; 215733_x_at; 234601_x_at; 227238_at; 239010_at; 214702_at;  1553319 _at; 235592_at; 229839_at; 230748_at; 203789_s_at; 226482_s_at; 215388_s_at; 1562053_at; 219911_s_at; 209351_at; 1552858_at; 215108_x_at; 226403_at; 207607_at; 228293_at; 210251_s_at; 1561318_at; 241036_at; 219759_at; 203592_s_at; 205302_at; 1568554_x_at; 1554276_at; 242842_at; 242868_at; 206859_s_at; 204580_at; and 207509_s_at or those set forth in Table 5 on the AFFYMETRIX GeneChip system (Affymetrix, Santa Clara, Calif.; HG-U133 Plus 2.0 GeneChips containing 53,613 probe sets) and (ii) a standard control representing the amount of the nucleic acid species in the corresponding sample from an average non-preeclamptic pregnant woman. 
         [0025]    Another aspect of the invention relates to a method for diagnosing, monitoring, or predicting preeclampsia in a pregnant woman using immunoassay(s). This method comprises the following steps: 
         [0026]    first, quantitatively determining the amount of one or more polypeptide species in a biological sample (test sample) obtained from the pregnant woman that bind to specific antibodies, said one or more polypeptide species being set forth in Table 8; 
         [0027]    second, comparing the amount of said one or more polypeptide species identified in the first step to a standard control representing the amount of the corresponding polypeptide species in a corresponding sample from an average non-preeclamptic pregnant woman (a control sample or standard control); wherein an increase (overexpression) and decrease (underexpression) in the amount of said at least one polypeptide species in the test sample as compared to the standard control indicates preeclampsia or an increased risk of developing preeclampsia. The biological sample is blood, serum, plasma, endometrial tissue, washing from the reproductive tract, urine, saliva, cerebral spinal fluid, amniotic fluid, or chorionic villus. The woman being examined is examined during the first trimester of gestation. In other embodiments, the woman is during the second or third trimester of gestation. 
         [0028]    As discussed above, immunoassays can be used to detect at least one secreted protein disclosed in Table 8, the expression levels of said at least one secreted protein, and comparison of said at least one secreted protein to a control (standard control) sample. Protein expression (secretion) can be detected by any suitable method, such as gas chromatography-mass spectrometry. In some embodiments, proteins are detected by immunoassays. 
         [0029]    Antibody binding is detected by techniques known in the art (e.g., radioimmunoassay, ELISA (enzyme-linked immunosorbant assay), “sandwich” immunoassays, immunoradiometric assays or Western blots. In some embodiments, antibody binding is detected by detecting a label on the primary antibody. In another embodiment, the primary antibody is detected by detecting binding of a secondary antibody or reagent to the primary antibody. In a further embodiment, the secondary antibody is labeled. Many methods are known in the art for detecting binding in an immunoassay and are within the scope of the present invention. In aspects of this invention, an automated detection assay is utilized. Methods for the automation of immunoassays include those described in U.S. Pat. Nos. 5,885,530, 4,981,785, 6,159,750, and 5,358,691, each of which is herein incorporated by reference. In some embodiments, the analysis and presentation of results is also automated. In other embodiments, the immunoassay described in U.S. Pat. Nos. 5,599,677 and 5,672,480; each of which is herein incorporated by reference. 
         [0030]    In various aspects of the invention, the woman being examined is examined during the first trimester of gestation. In other embodiments, the woman is during the second or third trimester of gestation. 
         [0031]    The term “nucleic acid” can be understood to mean, according to the present invention, either a double-stranded DNA, a single-stranded DNA or products of transcription of the said DNAs (e.g., RNA molecules). 
         [0032]    The term “preeclampsia” as used herein refers to a condition that occurs during pregnancy, diagnosed by the new onset of high blood pressure accompanied by the presence of proteins in the urine and may include edema (swelling). Preeclampsia, sometimes called toxemia of pregnancy, is related to a more serious disorder called “eclampsia”, which is preeclampsia together with seizure. These conditions usually develop during the second half of pregnancy (after 20 weeks), though they may develop shortly after birth or before 20 weeks of pregnancy. 
         [0033]    The term “primer extension reaction” as used herein refers to any polymerization process mediated by the action of a nucleotide polymerase, e.g., a DNA polymerase, by extending a predetermined polynucleotide sequence that is at least partially complementary to a template sequence under appropriate conditions. 
         [0034]    Probe set ID Nos: 205827_at; 215141_at; 202917_s_at; 215733x_at; 234601_x_at; 227238_at; 239010_at; 214702_at;  1553319 _at; 235592_at; 229839_at; 230748_at; 203789_s_at; 226482_s_at; 215388_s_at; 1562053_at; 219911_s_at; 209351_at; 1552858_at; 215108_x_at; 226403_at; 207607_at; 228293_at; 210251_s_at; 1561318_at; 241036_at; 219759_at; 203592_s_at; 205302_at; 1568554_x_at; 1554276_at; 242842_at; 242868_at; 206859_s_at; 204580_at; and 207509_s_at on the AFFYMETRIX GeneChip system (Affymetrix, Santa Clara, Calif.; HG-U133 Plus 2.0 GeneChips containing 53,613 probe sets), as used herein, refer to nucleic acid sequences found on the aforementioned AFFYMETRIX GeneChip system. The polynucleotide sequences are identified by database accession numbers (e.g., NM — 003394.1, etc.) in Tables 2, 5 and 9 and each of the accession numbers are hereby incorporated by reference in their entireties. 
         [0035]    “Standard control” or “control sample” as used herein refers to a sample suitable for use in a method of the present invention, e.g., in order for quantitatively determining the amount of a nucleic acid. Such a sample contains a known amount of the nucleic acid that closely reflects the average level of the nucleic acid in an average non-preeclamptic pregnant woman. Similarly, a “standard control” may be derived from an average healthy non-pregnant woman. 
         [0036]    “An increase and decrease in the amount of the nucleic acid or polypeptide species in the test sample as compared to the standard control” refers to a positive or negative change in amount from the standard control. An increase is preferably at least 2.00 fold, 2.25 fold, 2.50 fold, 2.75 fold, 3.00 fold, 3.25 fold, 3.5 fold, 3.75 fold, 4.00 fold, 4.25 fold, 4.50 fold, 4.75 fold, of 5.00 fold. Similarly, a decrease is at least 2.00 fold, 2.25 fold, 2.50 fold, 2.75 fold, 3.00 fold, 3.25 fold, 3.5 fold, 3.75 fold, 4.00 fold, 4.25 fold, 4.50 fold, 4.75 fold, of 5.00 fold. For example, an increase of 2+ or greater or −2 or below would be considered significant difference from control. These expression levels (+2 or −2) can also be referred to as “overexpressed”/“overexpression” or “underexpressed”/“underexpression”. 
         [0037]    A “polynucleotide hybridization method” as used herein refers to a method for detecting the presence and/or quantity of a polynucleotide based on its ability to form Watson-Crick base-pairing, under appropriate hybridization conditions, with a polynucleotide probe of a known sequence. Examples of such hybridization methods include Southern blotting and Northern blotting. 
         [0038]    “PCR primers” as used herein refer to oligonucleotides that can be used in a polymerase chain reaction (PCR) to amplify a nucleotide sequence originating from a nucleic acid (RNA transcript). Some aspects of the invention provide for primers that comprise the sequences of probe set ID Nos: 205827_at; 215141_at; 202917_s_at; 215733_x_at; 234601_x_at; 227238_at; 239010_at; 214702_at; 1553319_at; 235592_at; 229839_at; 230748_at; 203789_s_at; 226482_s_at; 215388_s_at; 1562053_at; 219911_s_at; 209351_at; 1552858_at; 215108_x_at; 226403_at; 207607_at; 228293_at; 210251_s_at; 1561318_at; 241036_at; 219759_at; 203592_s_at; 205302_at; 1568554_x_at; 1554276_at; 242842_at; 242868_at; 206859_s_at; 204580_at; and 207509_s_at on the AFFYMETRIX GeneChip system (Affymetrix, Santa Clara, Calif.; HG-U 133 Plus 2.0 GeneChips containing 53,613 probe sets). Various combinations of the aforementioned primers can be included in a primer kit as set forth herein. 
         [0039]    As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. Additionally, the terms “comprising”, “consisting of” and “consisting essentially of” are defined according to their standard meaning. The terms may be substituted for one another throughout the instant application in order to attach the specific meaning associated with each term. The phrases “isolated” or “biologically pure” refer to material that is substantially or essentially free from components which normally accompany the material as it is found in its native state. Thus, isolated peptides or nucleic acids, in accordance with the invention, preferably do not contain materials normally associated with the peptides in their in situ environment. 
       Materials and Methods 
     A. Samples 
       [0040]    Chorionic villus sampling (CVS) was performed as follows. Samples were donated from 2001-2005 by women who gave informed consent for research participation through procedures approved by the University of Pittsburgh and Magee-Women&#39;s Hospital Institutional Review Boards. Consent for the research was obtained by genetics counselors during the process of informed consent for the clinical CVS procedure. A physician specialized in CVS (W. A. H.) obtained specimens for clinical cytogenetics by aspiration of tissue into a 20 cc syringe containing Amniomax solution for cytogenetics cell culture (Invitrogen, Carlsbad, Calif.). The solution was not expected to affect RNA in any way, although experiments to test this opinion have not been performed (T. Jackson, Invitrogen; personal communication, Feb. 28, 2008). As part of the routine CVS procedure, the clinical specimen was poured from the syringe into a Petri dish to be assessed by the clinician for adequacy of amount aspirated (at least 25 mg of villi). No extra tissue was extracted for the research. If surplus tissue not needed for clinical analyses was available, villi grossly free of decidua and maternal blood were removed from the Amniomax in the Petri dish, placed in an Eppendorf tube, and snap-frozen in less than 10 minutes of CVS aspiration from the patient. Research specimens were stored at −80° C. for analyses after birth outcomes became available. Frozen samples occupied approximately 5-30 μl in the Eppendorf tubes. Eighty percent of all 160 consented participants had surplus CVS tissue for the research study. The rate of preeclampsia in the cohort was ˜3%. 
         [0041]    Certain preeclampsia (PE) and control (C) samples were chosen for study by microarray. Each of 4 CVS specimens from women who subsequently developed preeclampsia (PE) was matched based on parity, gestational age at CVS within 3 days, and race with 2 unaffected control (C) specimens for the microarray analysis. The sample size of 4 PE patients was determined by availability of samples in the CVS specimen bank meeting the study&#39;s diagnostic criteria and was the minimal number needed for statistical variance. PE was defined as new onset of hypertension and proteinuria after 20 weeks gestation with blood pressure ≧140 and/or 90 on at least 2 occasions at least 6 hours apart, and ≧300 mg of protein in a 24 hour urine (Gifford, et al., 2000). These women did not have underlying medical disorders or other obstetrical complications. Controls were defined as specimens from normotensive women with blood pressure &lt;140/90, no proteinuria, and without other pregnancy complications or underlying medical disorders. 
         [0042]    Additional samples (AS) for analysis by quantitative real time polymerase chain reaction (qRT-PCR) were prepared to test replication of the microarray findings. Twenty-four stored specimens were selected from women without pregnancy complications or underlying medical disorders. Matching AS to the PE cases was prioritized by parity, gestational age at CVS and race. Parity was limited to ≦3 pregnancies and gestational age at CVS within 3 days. 
         [0043]    Clinical data analysis was carried out. Demographic and clinical characteristics of participants were analyzed to examine underlying assumptions of group assignment. PE (N=4) and C (N=8) samples submitted for microarray procedures were compared using distributionally appropriate t-test or chi square with p≦0.05 set as level of significance. Additional samples (“AS”, N=24) selected for replication purposes were compared with PE and C groups using ANOVA and Bonferroni adjustment with p≦0.05 set as level of significance (SPSS 15.0, Carey, NC). 
         [0044]    Total RNA extraction and microarray procedures were conducted at the University of Pittsburgh Genomics and Proteomics Core Laboratory (GPCL). Specialized methods were applied for the particular tissue type, resulting in good RNA integrity (Agilent RIN≧6.0). In detail, the procedures were as follows: Each frozen CVS specimen was homogenized in 1 ml of TRIzol (Invitrogen, Carlsbad, Calif.) using a Polytron mechanical disrupter (Glen Mills, Clifton, N.J.) in less than 1 minute. Samples were incubated for at least 5 minutes at room temperature to allow complete dissociation. Two-tenths volume chloroform was then added. The reaction was mixed vigorously and allowed to incubate 3 minutes at room temperature. Following phase separation by centrifuging for 15 minutes at 12,000×g at 2-8° C., the aqueous phase was transferred to a clean microcentrifuge tube. The RNA was precipitated by adding 0.5 ml isopropyl alcohol, incubating for 5 minutes at room temperature and, finally, spinning 15 minutes at 12,000×g at 2-8° C. The supernatant was removed and the pellet washed by adding 1 ml 75% ethanol and spinning 5 minutes at 7,500×g at 2-8° C. The supernatant was carefully removed and the pellet was allowed to air dry for 5 minutes. The RNA was resuspended in nuclease free water. RNA integrity was evaluated on an Agilent Bioanalyzer (RIN≧6.0; Agilent, Santa Clara, Calif.). Samples were stored at −80° C. 
       B. Microarray Data Collection 
       [0045]    The Affymetrix GeneChip system (Affymetrix, Santa Clara, Calif.) was used for microarray analysis with HG-U133 Plus 2.0 GeneChips containing 53,613 probe sets. The GPCL facility conducted the analysis according to manufacturer&#39;s instructions as explained in more detail below. 
         [0046]    Microarray data collection was as follows: Two and one-half micrograms (μg) of total RNA was used as template in a reverse transcription reaction using oligo(dT) 24 primers attached to a T7 RNA polymerase promoter sequence. This single stranded cDNA was transformed into double stranded cDNA. Ten units of T4 DNA Polymerase were added and the reaction incubated at 16° C. for an additional 5 minutes. The reaction was stopped by the addition of EDTA to 0.03 M and cleaned up using an Affymetrix cDNA clean up column. At the end of the second strand reaction, the cDNA sample was mixed with DNA binding buffer and this mixture applied to the column. The column was spun in a microfuge to bind the cDNA to the membrane. DNA wash buffer supplied with the kit was used to wash the membrane, which was then dried by centrifugation. The cDNA was eluted with provided elution buffer. An aliquot of the ds-cDNA equivalent to 5-7 μg of starting RNA was added as template to an in vitro transcription reaction as per the Affymetrix IVT labeling kit. The resulting biotinylated cRNA was purified using an Affymetrix RNA clean up column. The procedure was identical to that for the DNA clean up using appropriately modified membranes and buffers as supplied. After elution the cRNA was quantified by reading the OD 260  of a 1:100 dilution on a spectrophotometer. In addition, 1 μl of the cRNA was run on an Agilent Bioanalyzer to verify that most product represented full size transcripts. An aliquot of 20 μg of cRNA was incubated at 94° C. in fragmentation buffer (40 mM Tris-Acetate pH 8.1, 100 mM KOAc, 30 mM MgOAc) for 35 minutes to break the RNA into segments of 35 to 200 bases. A 1 μl aliquot of the sample was run on an Agilent Bioanalyzer to verify that fragmentation resulted in RNA of the desired size distribution. Fifteen μg of the fragmented RNA was added to a final volume of 300 μl hybridization cocktail consisting of 1× hybridization buffer, 100 μg/ml Herring sperm DNA, 50 μg/ml Acetylated BSA, 50 pM Affymetrix Control Oligo B2, 1× Affymetrix Eukaryotic Hybridization Control. 1× hybridization buffer contains 100 mM MES, 1M Na+, 20 mM EDTA, 0.01% Tween 20. 
         [0047]    An appropriate volume of this sample was applied to HG-U133 Plus 2.0 GeneChip and incubated overnight at 45° C. with rotation. Following hybridization, the sample was removed and the GeneChip cassette filled with non-stringent wash buffer. The chip was loaded onto an Affymetrix 450 Fluidics station for wash and stain. Wash and stain protocols are the double stain protocols developed by Affymetrix for use with the Affymetrix 450 Fluidics Station. To remove unbound sample, arrays were first washed with non-stringent wash buffer followed by a stringent wash in 100 mM MES, 0.1M Na+, 0.01% Tween 20. The GeneChips were then stained for ten minutes in streptavidin-phycoerythrin (SAPE) solution. Non-stringent buffer was used to wash off the first stain solution. Signal amplification was achieved by ten minutes incubation with biotinylated anti-streptavidin, followed by a second ten minute incubation with SAPE. The chip was washed and filled with non-stringent wash buffer before being removed from the fluidics station and scanned using the GeneArray 3000 scanner. 
         [0048]    The Affymetrix GeneChip system uses a photolithographic process to manufacture 25-mer oligonucleotide probes directly on the array surface. Each mRNA or EST sequence is represented by 11 probe pairs (the probe set for this gene). Each probe pair consists of one feature containing a perfect match probe (PM) and an adjacent feature containing a mismatch probe (MM). The sequences of the two probes differ by one base in the central position. 
         [0049]    Data acquisition from the microarray was via accepted methods. Gene expression intensities were derived from the .cel files using dchip (Li et al., 2001) and BRB-Arrays Tools (Simon et al., 2007). The Affymetrix HG-U133 Plus 2.0 GeneChip contains 53,613 probe sets. 
         [0050]    QA/QC analysis of the data was carried out. Examination of the scanned images revealed a number of potential outliers in the array from patient #147. Subsequent data quality assurance/quality control (QA/QC) analysis by correlation and multiplicative-additive (M-A) plots confirmed that the inclusion of PE sample #147 led to group-wise high-expression outliers. All analyses were conducted including and excluding #147 for further assessment. 
         [0051]    Normalization was conducted as follows. The data were represented as PM only, ‘Signal’ (log 2 (PM-MM)), and Robust Multi-array Average (RMA) normalized in BRB-Array Tools (Simon et al., 2007). Alternative normalization methods were also conducted using the online program for Cancer Gene Expression Data Analysis (caGEDA) (Patel 2004). 
       C. Identification of Differentially Expressed Genes 
       [0052]    Following data quality assurance/quality control (QA/QC) and normalization procedures, differentially expressed genes were identified using the J5 test, Pooled Variance t-test (PVT) and Fold Change 3 (FC=[mean 1−mean 2]/mean 2) as implemented in the online program for Cancer Gene Expression Data Analysis (caGEDA) (Patel 2004). The J5 test is a gene-specific ratio between the mean differences in expression intensity of a gene in two groups to the average mean group difference of all m genes for the entire data set. These alternative methods were evaluated using QA/QC plots and ‘efficiency analysis,’ as implemented in caGEDA. In efficiency analysis, the data are split into two random subsets of roughly equal size. Both data sets are analyzed separately, yielding the number of genes found to be significant at each point over the range of the threshold of each test using the two data sets (N1 and N2, respectively). The degree of overlap is compared among tests as the number of genes in the overlap (N3) varies. Absent artifacts, the method that provides the highest internal consistency (highest degree of overlap) is preferred over methods that fail to yield internally consistent gene lists. QA/QC of sample #147 included many outliers. The genes found to be differentially expressed with the most efficient test, whether #147 was included or excluded, were considered further. Efficiency analysis was performed over the range of each test with 30 iterations. 
         [0000]    D. Prediction modeling 
         [0053]    Naïve Bayes prediction models were evaluated using leave-one-out cross-validation (LOOCV) in caGEDA (Patel 2004) with the J5 test used for feature selection. LOOCV refers to splitting the dataset in two, one group is a learning set and the other a test set. ‘Learning’ or classifier construction is conducted on the training set and evaluated in the test set. Modeling was attempted, both including and excluding array #147. For this step, the J5 test was wrapped within the evaluation loop (an iterative function within the computer program) to minimize the possibility of overtraining, the bias created when classifiers are built from the same dataset to be predicted. The models with lowest achieved classification error (ACE) found at the highest threshold (smallest number of genes) were preferred. 
       E. Functional Analysis 
       [0054]    Functional analysis of identified differentially expressed genes was carried out. Annotations were retrieved using a Batch Query given the Probe Set Identification numbers (Probe IDs) submitted to the Affymetrix NetAffx resource (NetAffx. 2007). Probe IDs and J5 scores were also submitted to Ingenuity Pathways Analysis 5.5 bioinformatics software (IPA) (Ingenuity 2007) for further investigation of known genes, molecular networks and functions. The Functional Analysis of a Network within IPA identified the biological functions and diseases that were most significantly related to the genes in the Network. The Network genes associated with biological functions and diseases in the Ingenuity Pathways Knowledge Base (IPKB) were analyzed within IPA by Fisher&#39;s exact tests to calculate a p-value, determining the probability that each biological function and/or disease assigned to a Network is due to chance alone, with p-value set at 0.05. IPA Functional Analysis has three primary categories of functions: Molecular and Cellular Functions, Physiological System Development and Function, and Diseases and Disorders. Eighty-five high level functional categories are classified under these primary categories. Lower level functions are classified within the high level categories. Specific functions are the lowest level functions found in IPA. Each lowest level function has a population of associated genes. Specific functions are drawn from manually curated animal and human research findings stored within the IPKB. Lower level functions and specific functions may be classified within multiple high level categories. 
       F. Quantitative RT-PCR 
       [0055]    Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted on a subset of genes to validate the microarray findings. cDNA was generated from 0.1 μg of total mRNA using the high capacity cDNA reverse transcription kit (Applied Biosystems [ABI]; Foster City, Calif.). The most appropriate endogenous control for this tissue was determined using the endogenous control plate (ABI). Ribosomal protein large P0 (RPLP0 [OMIM 180510]; ABI assay #Hs99999902) was selected and utilized as the endogenous control for each sample. The samples utilized for qRT-PCR included the original 12 microarray samples (PE &amp; C) as well as 24 additional samples (AS) from unaffected pregnancies. Each gene was evaluated in duplicate for each sample. Three genes were chosen for evaluation due to being the highest up- or down-regulated in the microarray findings. Pre-designed probe and primer sets were utilized for the CCK gene (ABI assay #Hs00174937), CTAG2 gene (ABI assay # Hs00535628) and LAIR2 gene (ABI assay # Hs00430498); gene names and OMIM identification numbers appear in Table 2. qRT-PCR was conducted according to routine protocols using the ABIPRISM 7000 system (ABI). 
         [0056]    Data analysis for qRT-PCR was conducted. Raw cycle threshold (C T ) values were determined using SDS1.1 software (ABI). Relative gene expression was determined using the comparative C T  method. A threshold value of 0.01 was used for LAIR2, 0.06 for CTAG2, and 0.16 for CCK. The average value for each sample was normalized to the average value of endogenous housekeeping gene RPLPO in the same well, resulting in ΔC T . (Dharmaraj 2007) ΔC t, reference  was the C t  value for the calibrator, normalized to RPLPO. Sample #38 was used as the calibrator for CCK and LAIR2 because it was a C specimen from a nulliparous nonsmoker at 11.0 weeks, an average gestational age at CVS. Sample #138, also a nulliparous nonsmoker at 11.0 weeks, was used as a calibrator for CTAG2 because there were undetermined values for #38. The difference between ΔC t  and the average calibrator expression value resulted in ΔΔC t . 2 (−ΔΔCt)  determined the fold change in expression level relative to the calibrator sample. Fold changes were analyzed by Kruskal-Wallis (KW) with significance set at p&lt;0.05. Analyses were carried out in Excel and SAS 9.1 (SAS Institute Inc., Cary, N.C.). 
       G. Fold Change Analysis 
       [0057]    Secondary analysis was conducted by expression fold changes (FC; Table 3). Scatterplots demonstrated that use of untransformed raw data was appropriate. The average expression level of each transcript for all cases and all controls were calculated. For pairs with average expression level of at least 30 in both cases and controls, the ratio of means in PE to C was calculated as the fold ratio. Fold ratio over 0 are analogous to fold change. Fold ratio below 0 is expressed as a decimal number, which is converted to fold change by dividing 100 by the numeric following the decimal (x −n ). Fold change greater than +2 or less than −2 was considered significant (Patel 2004). 
       Results: 
       [0058]    Clinical data are summarized in Table 1A. All women in the sample for microarray analysis (total N=12) were of advanced maternal age ≧35 years (35-44), White, and had normal fetal karyotype on CVS. PE (N=4) and C (N=8) groups did not differ in maternal age (p=0.34; Table 1A). Eleven of 12 samples were from nulliparous women and one C was a multiparous participant in her second pregnancy; groups did not differ by parity (p=1.00). Although not significantly different, BMI showed a trend toward significance with PE BMI 29.9±4.2 and C BMI 24.5±4.0 (mean±SD; p=0.06). Gestational age at CVS of both PE and C groups ranged from 10.7-12.4 weeks and did not differ between groups (p=0.78). PE and C groups did not differ in gestational age at delivery (p=0.11), birthweight (p=0.10), or infant sex (p=1.00). One C participant reported smoking; all others were self-reported nonsmokers. Groups did not differ in smoking (p=1.00). 
         [0059]    Additional clinical data for the four preeclampsia cases are shown in Tables 1B and 1C. The four PE participants met inclusion criteria for hypertension and proteinuria. Three were hyperuricemic for gestational age (Table 1C). Systolic and diastolic blood pressures at less than 20 weeks showed no preexisting hypertension. Participant #147 reached a severe blood pressure above 160/110 and was delivered by cesarean section. Participant #19 had low platelets, high creatinine, and was also delivered by cesarean section. Two PE cases (#21 and #147) delivered preterm, prior to 37 weeks&#39; gestation. PE #21 was obese (BMI≧30) and her infant was growth restricted, below 10 th  percentile for gestational age, delivered by pitocin induction. 
         [0060]    Participants in the AS group ranged in age from 34-45 years (mean 38.2 years) and were 10.4-13.0 weeks gestation (mean 11.5 weeks) with BMI 19.5-36.4 (mean 25.6) at CVS. Seven were nulliparous and 17 were multiparous women with uncomplicated pregnancies and unknown CVS gene expression patterns. All were White women and had normal fetal karyotype on CVS. All were self-reported nonsmokers. It is unknown whether each multiparous woman conceived with the same partner for all of her pregnancies. The AS group did not differ from PE or C by maternal age (p=0.59), gestational age at CVS (p=0.66), or BMI (p=0.19) at CVS. 
         [0061]    Oligonucleotide microarray analysis of CVS specimens by the methods described herein produced global gene expression patterns in early pregnancies destined for preeclamptic versus unaffected outcomes. Four PE compared with 8 C specimens resulted in a set of 36 differentially expressed genes. 
         [0062]    The QA/QC correlogram scatterplots comparing signal intensity across the microarrays were prepared that included case #147 ( FIG. 2A ) or excluded #147 ( FIG. 2B ). High-expression outliers found in #147 resulted in subsequent analyses being performed twice, alternatively including or excluding #147. Robust Multi-array Average (RMA) normalization in RMA-BRB-Array Tools (Simon et al., 2007) resulted in a coefficient of variation of 0.001. 
         [0063]    Expression levels were assessed using the J5 test, PVT and FC as implemented in caGEDA (Patel 2004). The J5 test using the raw Perfect Match data (Supplement) only led to the most efficient and internally consistent set of differentially expressed genes, exhibiting 40% consistency in the set of genes found to be differentially expressed between PE and C ( FIG. 3 ). This contrasts with less than 5% internal consistency explained by PVT and approximately 10% explained by FC. Fold change and the t-test are known to lead to high false-positive rates, especially with small sample number (Patel 2004). Efficiency analysis in J5 identified 36 genes of interest in the overlap of gene sets with and without #147. 
         [0064]    Prediction modeling was explored with Naïve Bayes models using LOOCV ( FIG. 4 ). Modeling was conducted with and without sample #147. The modeling that included #147 exhibited perfect accuracy, equaling sensitivity and specificity (SN=SP=ACC=1.0). The model with a J5 score of 8, which excluded #147, led to the lowest ACE for potential genomic biomarkers of preeclampsia with 90% accuracy. 
         [0065]    The Affymetrix probe identification numbers (probe IDs) submitted to NetAffx resulted in annotations for gene names and Gene Ontology (GO) Molecular Function Description for the 36 genes of interest (Tables 2 and 9; Table 9 includes OMIM numbers, gene names and symbols). Five genes of interest were up-regulated and 31 were down-regulated. At this time, 7 are mapped genes with unknown functions and 4 are unmapped with unknown function. NetAffx identified GO Pathway information for only 3 of the 36 genes of interest (Table 9). 
         [0066]    IPA identified potential relationships among some of the genes of interest. Two Networks were developed from the 36 genes imputed with other genes associated through previous studies annotated in the IPKB ( FIG. 1 ). Top Functions and Diseases associated with Network 1 involving 10 of the 36 genes of interest were Cancer, Respiratory Disease, and Cellular Movement. Top Functions and Diseases associated with Network 2, involving 7 genes of interest, were Inflammatory Disease, Cellular Movement, and Hematological System Development and Function. MMP12 was the only gene shared between Networks 1 and 2. 
         [0067]    Seventy-two Function and Disease categories among the genes of interest reached significance (p&lt;0.05). Ten functional categories achieved the highest significance levels and included more than one of the 36 genes of interest (Table 3). Categories comprising the 2 Networks among the genes of interest included lower level function subcategories. Lower level functions within Cancer were cancer, neoplasia, tumorigenesis, ovarian cancer, gonadal tumor, mitosis, cell rounding, invasion, apoptosis, adhesion, migration, attachment, and detachment. Respiratory Disease was the 28 th  most significant Function and Disease category which included FN1, MMP12, CCK, and EPAS1 (−log p-value=1.63E-03-2.72E-02). Lower level functions within Respiratory Disease included primary pulmonary hypertension, lung tumor, lung cancer, adhesion, neonatal surfactant, and emphysema. Cellular Movement included migration of all types of leukocytes, blood, intestinal, embryonic, neuronal, bone marrow, gonadal and cancer cells, cell movement, immobilization, scattering, and invasion. Inflammatory Disease was the 62 nd  most significant Function and Disease category which included F11R, S100A8, and MMP12 (−log p-value=8.24E-03-2.42E-02) and lower level functions related to juvenile rheumatoid arthritis and emphysema. Hematological System Development and Function included migration and cell movement of all types of leukocytes, cell spreading, adhesion, immobilization, replacement, and proliferation. 
         [0068]    Relative quantitation of LAIR2, CCK, and CTAG2 compared to calibrator sample was conducted by qRT-PCR. LAIR2 was significantly down-regulated by a median fold change of 0.21 in PE, compared to median fold change 1.17 in C, and 4.99 in AS (p=0.0004). The median fold change in CCK was 25.37 (range 1.01-51.45) in PE, compared to 2.19 (0.46-30.38) in C, and 5.77 (0.07-26.63) in AS. The raw microarray expression level and qRT-PCR fold change in each PE sample were 4223.4 and 51.45 in #19, 732 and 1.72 in #21, 7339.4 and 49.01 in #58, 59.7 and 1.01 in # 147. Although the trend for CCK fold change was in the same direction as the microarray overexpression, the qRT-PCR differences by Kruskal-Wallis were not significant between groups (p=0.60). qRT-PCR for CTAG2 resulted in 11 of 36 samples as “undetermined.” The values for endogenous control RPLPO were consistent among all 36 samples for each of the 3 genes in qRT-PCR with an average of 24.25±0.12 in CTAG2. The median fold change in CTAG2 was 5.78 (range 0.28-11.27) in PE, compared to 0.04 (0.01-1.00) in C, and 0.90 (0.02-12.64) in AS. The trend in CTAG2 fold change was toward overexpression in PE, but the differences were not significant (p=0.39). 
       Discussion: 
       [0069]    This microarray analysis of surplus CVS produced differences in global gene expression in placentas of early pregnancies destined for preeclampsia. Utilization of first trimester placentas with known pregnancy outcomes, oligonucleotide genechips, and subsequent prediction modeling distinguish our study from previous placental microarray investigations in preeclampsia (Founds et al., 2008) qRT-PCR confirmed the trends in over- and underexpression in the microarray analysis. The variation in CTAG2 qRT-PCR expression patterns may indicate methylation in nonexpressors denoted as “undetermined” among all 3 groups of samples (Lethe et al., 1998). CCK was also up-regulated 3.1 fold in placentas of preeclamptic pregnancies at 29-32 weeks in a previous study (Reimer el al., 2002). Overall, our results directly support the concept of the placental origins of the disorder (Redman et al., 2005) and allow for targeted investigation of placental-derived biomarkers in early pregnancy. Assessment of cause rather than effect of preeclampsia is likely to have been more discernable in the first trimester placental tissues. 
         [0070]    The findings in this study suggest that impaired placentation in preeclampsia may be associated with an overall deficiency rather than an excess of gene expression, insofar as 31 of the 36 genes of interest were down-regulated. Preconceptional testing of susceptibility to preeclampsia could be developed from variants of the genes of interest. In addition, several produce secreted protein ( FIG. 1 ), such that measurement of one or a combination of these biomarker proteins in maternal blood in the first trimester may prove to be a predictive screening test for preeclampsia. 
         [0071]    Innate immune responses at the maternal-fetal interface are likely to be represented by our genes of interest. Remarkably, 12 of the 36 genes, 7 not previously associated with preeclampsia, are involved in immune dysregulation (Table 9). All of the immunoregulatory genes except S100A8 were down-regulated, implicating deficient, blocked, or impaired function. LAIR2, HPS3, and SART3 are immune-related genes (Table 9) that were not incorporated by IPA into the immune pathway ( FIG. 1 ; Table 3). The immune dysregulated cells may be trophoblasts, which are fetoplacental epithelial cells (Petty et al., 2006) that act as a pregnancy-specific component of the innate immune system (Guleria et al., 2000). By day 14 post conception, cytotrophoblasts (CTBs) have breached the chorionic basement membrane, switching from a proliferative to an invasive phenotype as extravillous trophoblasts (EVTs) (Huppertz et al., 2007). Lower level functions in Networks 1 and 2, e.g., inflammation, migration, and invasion, are involved in CTB placentation processes ( FIG. 1 ). The EVTs faun cell columns contacting maternal immune cells in the decidua (Benirschke et al., 2006). From these columns, EVTs invade the uterine wall and remodel the maternal spiral arteries by displacing smooth muscle and endothelial cells (Pijnenborg et al., 1983). Normal trophoblast development differs from cancer in that proliferation ceases during invasion (Huppertz et al., 2007). Various genes associated with both of these processes were down-regulated in preeclampsia (Tables 2 and 9). In the current analysis, no notable differential expression existed between PE and C in EVT epithelial or integrins (Damsky et al., 1992; Irving et al., 1995) or human leukocyte antigens (Apps et al., 2007) identified in other studies as dysregulated in CTBs of later gestation. Alternatively, some of the differentially expressed immunoregulatory genes may suggest abnormalities of fetoplacental Hofbauer cells, which are macrophages that populate the villous core (Benirschke et al., 2006). The maternal innate immune system predominates at this stage with 70% of decidual leukocytes consisting of natural killer cells (NK), 20-25% macrophages and about 2% dendritic cells (Mor 2006). Approximately 1-3% of decidual immune cells at this time are adaptive system T lymphocytes; no B cells are present (Lessin et al., 1988). Thus, some of the immunoregulatory genes of interest could also be of maternal origin. Finally, one cannot exclude the potential contribution of circulating fetal or maternal immune cells in the placenta (Huppertz et al., 2007). 
         [0072]    Surprisingly, a number of differentially expressed genes may be found in decidual stroma, including MUC15 (Shyu et al., 2007), IGFBP1 (Bischof et al., 1989), and PAEP (Jeschke et al., 2005). Although the goal of CVS is to obtain chorionic tissue for fetal genetic diagnosis, maternal decidual tissue is invariably present, as corroborated by our microarray analysis. Decidual tissue likely derives from placental septae projecting upwards from the basal plate towards the chorionic plate that contain an admixture of decidual cells, EVTs, and occasional trophoblast giant cells (Benirschke et al., 2006). On balance, the results suggest that preeclampsia may be associated with impaired decidualization. Whether this is etiological or secondary to suboptimal interaction with and stimulation by trophoblasts or maternal immune cells, or both is currently unknown. An alternative explanation, albeit less likely, is that there are fewer of these septae in early preeclampsia placentas, thus decreasing decidual tissue and consequently decidual gene expression in these CVS specimens. 
         [0073]    Ten genes of interest were not found in any of the 72 Function and Disease categories assessed by IPA or located in current literature searches in conjunction with preeclampsia: CTAG2, MUC15, OXGR1, SCARA5, MAGEB6, TNRC9, TMC4, DEPDC7, RUFY3, and LAIR2. We suggest functional groupings, other than immune/inflammation, integrating these with all genes of interest (Table 4). 
         [0074]    In order to examine hypotheses concerning hypoxia inducible transcription factors and oxidative stress, a secondary analysis of fold changes was conducted with the caveat that a high rate of false positives could be expected (Table 5) (Patel 2004). The concept that the placenta is hypoxic or over-expresses HIF-2α protein during early gestation, thereby impairing trophoblast invasion in preeclampsia, (Rajakumar et al., 2001) is not corroborated by this microarray analysis. We interrogated 26 genes proven to be HIF target genes (Wenger et al., 2005) and were been shown to be over-represented in placentas delivered from preeclamptic women (Tables 2 and 9) (Rajakumar et al., 2007). Only IGFBP1, WT1 and TH genes showed differential expression in one probe. Moreover, IGFBP1 and TH are typically up- and not down-regulated by hypoxia (Rajakumar et al., 2004; Tazuke et al., 1998). Interestingly, EPAS1 or HIF-2α (Tables 2 and 9) expression was markedly decreased, but did not consistently correlate with putative specific HIF-2α target genes (Table 3), (Lofstedt et al., 2007) suggesting adequate HIF-2α protein levels, transcriptional activity or compensation despite markedly reduced HIF-2α mRNA expression. 
         [0075]    Nor were we able to support the differential expression of oxidative stress regulated genes at this early stage of pregnancy (Jauniaux et al., 2000; Many et al. 2000). We interrogated fold changes in 11 genes previously shown to be regulated by oxidative stress (Table 7), (Allen et al., 2000) and expression differences were nonsignificant. In fact, blood flow and oxygen delivery to the intervillous space begins around 10-12 weeks of gestation (Jauniaux et al., 2000), but expression profiles of the hypoxia (Table 6) and oxidative stress (Table 7) regulated genes do not support the concept of an undue delay or acceleration of this crucial physiological event, respectively. Thus, ischemia-hypoxia and oxidative stress due to reperfusion injury are likely to be later events in preeclampsia. 
         [0076]    Noteworthy is that 17 of the 36 genes identified by the Naïve Bayes prediction model and J5 test were among the 152 identified by 2-fold FC analysis. Thus, there is considerable intersection of the two analytical approaches. The finding of aberrant decidualization in early placentas of preeclampsia revealed by the prediction modeling is bolstered by the FC analysis, insofar as FSTL3 (FC −2.56) (Jones et al., 2002) and prolactin (FC −7.86) (Telgmann 1998) are downregulated (Table 5). Additionally, marked downregulation of granulysin in the FC analysis (FC −23.51) further supports immune dysregulation in decidua (Mincheva-Nilsson et al., 2000). 
         [0077]    All patents, patent applications, provisional applications, and publications referred to or cited herein, supra or infra, are incorporated by reference in their entirety, including all figures and tables, to the extent they are not inconsistent with the explicit teachings of this specification. 
         [0078]    It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application. 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 1A 
               
             
             
               
                   
               
               
                 Clinical characteristics of total microarray study sample (N = 12). 
               
             
          
           
               
                   
                 Control (N = 8) 
                 Preeclampsia †  (N = 4) 
               
               
                   
                   
               
             
          
           
               
                 Maternal age (years) 
                 38.1 ± 3.1 
                 36.5 ± 0.6 
               
               
                 Nulliparous (N) 
                 7 
                 4 
               
               
                 BMI at CVS 
                 24.5 ± 4.0 
                 29.9 ± 4.2 
               
               
                 Gestational weeks at CVS 
                 11.3 ± 0.6 
                 11.4 ± 0.7 
               
               
                 Gestational weeks at delivery 
                 39.8 ± 1.2 
                 37.5 ± 2.9 
               
               
                 Birth weight (grams) 
                 3346.7 ± 437.4 
                 2717.8 + 643.1 
               
               
                 Infant sex 
               
               
                 Female 
                 4 
                 2 
               
               
                 Male 
                 4 
                 2 
               
               
                 Smoking 
                 1 
                 0 
               
               
                   
               
               
                   † Preeclampsia definition is based on the National High Blood Pressure Education Program Working Group (Gifford et al., 2000). 
               
               
                 Mean ± SD; level of significance, p ≦ 0.05. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 1B 
               
             
             
               
                   
               
               
                 Additional data for preeclampsia cases. 
               
             
          
           
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Average 
                 Average 
               
               
                 PE case 
                 Maternal 
                   
                   
                   
                   
                   
                   
                   
                 systolic BP 
                 diastolic BP 
               
               
                 (Patient 
                 age at 
                   
                   
                   
                   
                 Gestational 
                 Gestational 
                 Mode of 
                 (prior to 20 
                 (prior to 20 
               
               
                 ID) 
                 CVS 
                 Gravidity 
                 Parity 
                 Race 
                 BMI 
                 age at CVS 
                 age at delivery 
                 delivery 
                 wks) 
                 wks) 
               
               
                   
               
             
          
           
               
                 1 (19) 
                 37 
                 2 
                 0 
                 W 
                 27.5 
                 11.4 
                 38 
                 C-section 
                 109 
                 69 
               
               
                 2 (21) 
                 36 
                 2 
                 0 
                 W 
                 36.0 
                 12.4 
                 35.7 
                 Vaginal 
                 116 
                 69 
               
               
                 3 (58) 
                 36 
                 1 
                 0 
                 W 
                 26.8 
                 10.7 
                 41.3 
                 Vaginal 
                 129 
                 77 
               
               
                  4 (147) 
                 37 
                 1 
                 0 
                 W 
                 29.1 
                 11.0 
                 34.9 
                 C-section 
                 102 
                 69 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 1C 
               
             
             
               
                   
               
               
                 Further additional data for preeclampsia cases. 
               
             
          
           
               
                 PE case 
                 Average 
                 Average 
                 Proteinuria 
                 Uric acid (&gt;1SD 
                 Birth 
                 Birth 
                   
               
               
                 (Patient 
                 systolic BP 
                 diastolic BP 
                 (grams per 24 
                 for gestational age [+], 
                 weight 
                 weight 
               
               
                 ID) 
                 (at delivery) 
                 (at delivery) 
                 hour urine) 
                 mg/dL) 
                 (grams) 
                 percentile 
                 Other 
               
               
                   
               
             
          
           
               
                 1 (19) 
                 145 
                 80 
                 1.06 
                 10.2 (+)  
                 3241 
                 &gt;10 
                 Max BP 155/90, Low 
               
               
                   
                   
                   
                   
                   
                   
                   
                 platelets to 87K, 
               
               
                   
                   
                   
                   
                   
                   
                   
                 creatinine 1.1 mg/dL 
               
               
                 2 (21) 
                 155 
                 90 
                 4.76 
                 8.1 (+) 
                 1965 
                 &lt;3 
                 Max BP 164/88, 
               
               
                   
                   
                   
                   
                   
                   
                   
                 IUGR 
               
               
                 3 (58) 
                 163 
                 80 
                 0.77 
                 4.0 (−) 
                 3265 
                 &gt;10 
                 Max systolic BP 184 
               
               
                  4 (147) 
                 151 
                 93 
                 0.74 
                 5.2 (+) 
                 2400 
                 &gt;10 
                 Max BP 176/115 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Genes differentially expressed in first trimester PE. 
               
             
          
           
               
                   
                   
                 Condition in 
                   
                   
               
               
                   
                 J5 Score 
                 Preclampsia 
                 Gene 
               
               
                 Probe Set ID 
                 (3 vs 8) 
                 Group 
                 Symbol 
                 Target Description 
               
               
                   
               
             
          
           
               
                 1561318_at 
                 −9.691 
                 Underexpressed 
                 — 
                 gb: BC043169.1 /DB_XREF = gi: 27693226 
               
               
                   
                   
                   
                   
                 /TID = Hs2.438491.1 /CNT = 2 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 /UG = Hs.438491 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , clone 
               
               
                   
                   
                   
                   
                 IMAGE: 5287025, mRNA /DEF =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 5287025, mRNA. 
               
               
                 1562053_at 
                 −8.578 
                 Underexpressed 
                 — 
                 gb: BC043556.1 /DB_XREF = gi: 27694238 
               
               
                   
                   
                   
                   
                 /TID = Hs2.432875.1 /CNT = 3 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 /UG = Hs.432875 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , clone 
               
               
                   
                   
                   
                   
                 IMAGE: 5184785, mRNA /DEF =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 5184785, mRNA. 
               
               
                 234601_x_at 
                 8.373 
                 Overexpressed 
                 — 
                 gb: AK026385.1 /DB_XREF = gi: 10439235 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 1 /TID = Hs.306841.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 /UG = Hs.306841 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens  cDNA: FLJ22732 fis, 
               
               
                   
                   
                   
                   
                 clone HSI15880 /DEF =  Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                 FLJ22732 fis, clone HSI15880. 
               
               
                 242842_at 
                 −14.512 
                 Underexpressed 
                 — 
                 gb: BF435734 /DB_XREF = gi: 11448036 
               
               
                   
                   
                   
                   
                 /DB_XREF = nab41a03.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3268133 /FEA = EST /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.301745.0 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.301745 /UG_TITLE = ESTs, Weakly similar 
               
               
                   
                   
                   
                   
                 to ALU1_HUMAN ALU SUBFAMILY J 
               
               
                   
                   
                   
                   
                 SEQUENCE CONTAMINATION WARNING 
               
               
                   
                   
                   
                   
                 ENTRY ( H. sapiens ) 
               
               
                 207607_at 
                 −9.23 
                 Underexpressed 
                 ASCL2 
                 gb: NM_005170.1 /DB_XREF = gi: 4885664 
               
               
                   
                   
                   
                   
                 /GEN = ASCL2 /FEA = FLmRNA /CNT = 3 
               
               
                   
                   
                   
                   
                 /TID = Hs.135639.0 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.135639 /LL = 430 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 achaete-scute complex ( Drosophila ) homolog-like 2 
               
               
                   
                   
                   
                   
                 (ASCL2), mRNA. /PROD = achaete-scute complex 
               
               
                   
                   
                   
                   
                 homolog-like 2 /FL = gb: NM_005170.1 
               
               
                 215141_at 
                 13.765 
                 Overexpressed 
                 C4orf10 
                 gb: AA493300 /DB_XREF = gi: 2223141 
               
               
                   
                   
                   
                   
                 /DB_XREF = ng97e11.s1 /CLONE = IMAGE: 942764 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 6 /TID = Hs.104258.2 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 /UG = Hs.104258 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens  mRNA, exon 1, 2, 3, 4, 
               
               
                   
                   
                   
                   
                 clone: RES4-24A 
               
               
                 1568554_x_at 
                 −10.67 
                 Underexpressed 
                 C6orf142 
                 gb: AF317590.1 /DB_XREF = gi: 12751196 
               
               
                   
                   
                   
                   
                 /TID = Hs2.383544.1 /CNT = 1 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 /UG = Hs.383544 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens  T cell receptor beta 
               
               
                   
                   
                   
                   
                 chain (BV16S1) mRNA, partial cds /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  T cell receptor beta chain (BV16S1) mRNA, 
               
               
                   
                   
                   
                   
                 partial cds. 
               
               
                 205827_at 
                 20.414 
                 Overexpressed 
                 CCK 
                 gb: NM_000729.2 /DB_XREF = gi: 4755130 
               
               
                   
                   
                   
                   
                 /GEN = CCK /FEA = FLmRNA /CNT = 40 
               
               
                   
                   
                   
                   
                 /TID = Hs.80247.0 /TIER = FL + Stack /STK = 23 
               
               
                   
                   
                   
                   
                 /UG = Hs.80247 /LL = 885 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 cholecystokinin (CCK), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = cholecystokinin preproprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000729.2 
               
               
                 215388_s_at 
                 −8.449 
                 Underexpressed 
                 CFH /// 
                 gb: X56210.1 /DB_XREF = gi: 30132 /GEN = H 36-2 
               
               
                   
                   
                   
                 CFHR1 
                 /FEA = mRNA /CNT = 4 /TID = Hs.296941.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 /UG = Hs.296941 /LL = 3079 
               
               
                   
                   
                   
                   
                 /DEF =  H. sapiens  mRNA for complement Factor H- 
               
               
                   
                   
                   
                   
                 related protein 1, clone H 36-2. /PROD = FHR-1; 
               
               
                   
                   
                   
                   
                 complement Factor H-related protein 1 
               
               
                 215733_x_at 
                 8.519 
                 Overexpressed 
                 CTAG2 
                 gb: AJ012833.1 /DB_XREF = gi: 3893216 
               
               
                   
                   
                   
                   
                 /GEN = CAMEL /FEA = mRNA /CNT = 5 
               
               
                   
                   
                   
                   
                 /TID = Hs.87225.1 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.87225 /LL = 30848 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 mRNA for CTL-recognized antigen on melanoma 
               
               
                   
                   
                   
                   
                 (CAMEL). /PROD = CTL-recognized antigen on 
               
               
                   
                   
                   
                   
                 melanoma (CAMEL) 
               
               
                 228293_at 
                 −9.406 
                 Underexpressed 
                 DEPDC7 
                 gb: AJ245600.1 /DB_XREF = gi: 5763726 
               
               
                   
                   
                   
                   
                 /GEN = TR2D15 /FEA = mRNA /CNT = 32 
               
               
                   
                   
                   
                   
                 /TID = Hs.180545.0 /TIER = Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.180545 /DEF =  Homo sapiens  mRNA for 
               
               
                   
                   
                   
                   
                 hypothetical protein (TR2D15 gene). 
               
               
                   
                   
                   
                   
                 /PROD = hypothetical protein 
               
               
                 235592_at 
                 −8.249 
                 Underexpressed 
                 ELL2 
                 gb: AW960145 /DB_XREF = gi: 8149829 
               
               
                   
                   
                   
                   
                 /DB_XREF = EST372216 /FEA = EST /CNT = 12 
               
               
                   
                   
                   
                   
                 /TID = Hs.100636.0 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.100636 /UG_TITLE = ESTs 
               
               
                 242868_at 
                 −15.342 
                 Underexpressed 
                 EPAS1 
                 gb: T70087 /DB_XREF = gi: 681235 
               
               
                   
                   
                   
                   
                 /DB_XREF = yc17g11.s1 /CLONE = IMAGE: 80996 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 7 /TID = Hs.307559.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 /UG = Hs.307559 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 226482_s_at 
                 −8.441 
                 Underexpressed 
                 F11R 
                 gb: AI814545 /DB_XREF = gi: 5425760 
               
               
                   
                   
                   
                   
                 /DB_XREF = wj74d11.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2408565 /FEA = EST /CNT = 181 
               
               
                   
                   
                   
                   
                 /TID = Hs.12284.0 /TIER = Stack /STK = 23 
               
               
                   
                   
                   
                   
                 /UG = Hs.12284 /UG_TITLE =  Homo sapiens , clone 
               
               
                   
                   
                   
                   
                 IMAGE: 2989556, mRNA, partial cds 
               
               
                 214702_at 
                 −8.2 
                 Underexpressed 
                 FN1 
                 gb: AJ276395.1 /DB_XREF = gi: 12053816 /GEN = FN 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 52 /TID = Hs.321592.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 /UG = Hs.321592 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  mRNA for MSF-FN70 (FN 
               
               
                   
                   
                   
                   
                 gene). /PROD = migration stimulation factor FN70 
               
               
                 203592_s_at 
                 −10.048 
                 Underexpressed 
                 FSTL3 
                 gb: NM_005860.1 /DB_XREF = gi: 5031700 
               
               
                   
                   
                   
                   
                 /GEN = FSTL3 /FEA = FLmRNA /CNT = 129 
               
               
                   
                   
                   
                   
                 /TID = Hs.25348.0 /TIER = FL + Stack /STK = 33 
               
               
                   
                   
                   
                   
                 /UG = Hs.25348 /LL = 10272 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 follistatin-like 3 (secreted glycoprotein) (FSTL3), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = follistatin-like 3 glycoprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: U76702.1 gb: NM_005860.1 
               
               
                 241036_at 
                 −9.764 
                 Underexpressed 
                 HPS3 
                 gb: AA215451 /DB_XREF = gi: 1815195 
               
               
                   
                   
                   
                   
                 /DB_XREF = zr97d04.s1 /CLONE = IMAGE: 683623 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 4 /TID = Hs.189025.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 /UG = Hs.189025 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 205302_at 
                 −10.347 
                 Underexpressed 
                 IGFBP1 
                 gb: NM_000596.1 /DB_XREF = gi: 4504614 
               
               
                   
                   
                   
                   
                 /GEN = IGFBP1 /FEA = FLmRNA /CNT = 268 
               
               
                   
                   
                   
                   
                 /TID = Hs.102122.0 /TIER = FL + Stack /STK = 117 
               
               
                   
                   
                   
                   
                 /UG = Hs.102122 /LL = 3484 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 insulin-like growth factor binding protein 1 
               
               
                   
                   
                   
                   
                 (IGFBP1), mRNA. /PROD = insulin-like growth 
               
               
                   
                   
                   
                   
                 factor binding protein 1 /FL = gb: NM_000596.1 
               
               
                   
                   
                   
                   
                 gb: M31145.1 gb: M20841.1 
               
               
                 209351_at 
                 −8.699 
                 Underexpressed 
                 KRT14 
                 gb: BC002690.1 /DB_XREF = gi: 12803708 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 212 /TID = Hs.117729.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 53 /UG = Hs.117729 
               
               
                   
                   
                   
                   
                 /LL = 3861 /UG_GENE = KRT14 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens , keratin 14 (epidermolysis bullosa simplex, 
               
               
                   
                   
                   
                   
                 Dowling-Meara, Koebner), clone MGC: 3944, 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. /PROD = keratin 14 
               
               
                   
                   
                   
                   
                 (epidermolysis bullosa simplex, Dowling-Meara, 
               
               
                   
                   
                   
                   
                 Koebner) /FL = gb: NM_000526.1 gb: BC002690.1 
               
               
                 207509_s_at 
                 −18.871 
                 Underexpressed 
                 LAIR2 
                 gb: NM_002288.2 /DB_XREF = gi: 10947100 
               
               
                   
                   
                   
                   
                 /GEN = LAIR2 /FEA = FLmRNA /CNT = 6 
               
               
                   
                   
                   
                   
                 /TID = Hs.43803.1 /TIER = FL /STK = 5 
               
               
                   
                   
                   
                   
                 /UG = Hs.43803 /LL = 3904 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 leukocyte-associated Ig-like receptor 2 (LAIR2), 
               
               
                   
                   
                   
                   
                 transcript variant 1, mRNA. /PROD = leukocyte- 
               
               
                   
                   
                   
                   
                 associated Ig-like receptor 2, isoforma 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002288.2 
               
               
                 239010_at 
                 −8.134 
                 Underexpressed 
                 LOC440157 
                 gb: AI744280 /DB_XREF = gi: 5112568 
               
               
                   
                   
                   
                   
                 /DB_XREF = tr08f08.x1 /CLONE = IMAGE: 2217735 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 9 /TID = Hs.227056.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 /UG = Hs.227056 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs, Moderately similar to 
               
               
                   
                   
                   
                   
                 mitochondrial outer membrane protein ( H. sapiens ) 
               
               
                 219759_at 
                 −9.916 
                 Underexpressed 
                 LRAP 
                 gb: NM_022350.1 /DB_XREF = gi: 11641260 
               
               
                   
                   
                   
                   
                 /GEN = LOC64167 /FEA = FLmRNA /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.280380.0 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.280380 /LL = 64167 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 aminopeptidase (LOC64167), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = aminopeptidase /FL = gb: AF191545.1 
               
               
                   
                   
                   
                   
                 gb: NM_022350.1 
               
               
                 1552858_at 
                 −8.915 
                 Underexpressed 
                 MAGEB6 
                 gb: NM_173523.1 /DB_XREF = gi: 27734966 
               
               
                   
                   
                   
                   
                 /TID = Hs2.376011.1 /CNT = 4 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 2 /LL = 158809 
               
               
                   
                   
                   
                   
                 /UG_GENE = FLJ40242 /UG = Hs.376011 
               
               
                   
                   
                   
                   
                 /UG_TITLE = hypothetical protein FLJ40242 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  hypothetical protein FLJ40242 
               
               
                   
                   
                   
                   
                 (FLJ40242), mRNA. /FL = gb: NM_173523.1 
               
               
                 204580_at 
                 −17.183 
                 Underexpressed 
                 MMP12 
                 gb: NM_002426.1 /DB_XREF = gi: 4505206 
               
               
                   
                   
                   
                   
                 /GEN = MMP12 /FEA = FLmRNA /CNT = 72 
               
               
                   
                   
                   
                   
                 /TID = Hs.1695.0 /TIER = FL + Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.1695 /LL = 4321 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 matrix metalloproteinase 12 (macrophage elastase) 
               
               
                   
                   
                   
                   
                 (MMP12), mRNA. /PROD = matrix metalloproteinase 
               
               
                   
                   
                   
                   
                 12 preproprotein /FL = gb: L23808.1 
               
               
                   
                   
                   
                   
                 gb: NM_002426.1 
               
               
                 227238_at 
                 −8.014 
                 Underexpressed 
                 MUC15 
                 gb: W93847 /DB_XREF = gi: 1422970 
               
               
                   
                   
                   
                   
                 /DB_XREF = zd97a07.s1 /CLONE = IMAGE: 357396 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 89 /TID = Hs.24139.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 21 /UG = Hs.24139 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens  cDNA: FLJ23137 fis, 
               
               
                   
                   
                   
                   
                 clone LNG08842 
               
               
                 1553319_at 
                 −8.245 
                 Underexpressed 
                 OXGR1 
                 gb: AF370886.1 /DB_XREF = gi: 21728283 
               
               
                   
                   
                   
                   
                 /GEN = GPR99 /TID = Hs2.352218.1 /CNT = 4 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL /STK = 1 /LL = 27199 
               
               
                   
                   
                   
                   
                 /UG = Hs.352218 /DEF =  Homo sapiens  G protein- 
               
               
                   
                   
                   
                   
                 coupled receptor GPR99 (GPR99) mRNA, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = G protein-coupled receptor GPR99 
               
               
                   
                   
                   
                   
                 /FL = gb: AF370886.1 gb: NM_080818.1 
               
               
                 206859_s_at 
                 −15.642 
                 Underexpressed 
                 PAEP 
                 gb: NM_002571.1 /DB_XREF = gi: 4505582 
               
               
                   
                   
                   
                   
                 /GEN = PAEP /FEA = FLmRNA /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.82269.0 /TIER = FL + Stack /STK = 13 
               
               
                   
                   
                   
                   
                 /UG = Hs.82269 /LL = 5047 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 progestagen-associated endometrial protein 
               
               
                   
                   
                   
                   
                 (placental protein 14, pregnancy-associated 
               
               
                   
                   
                   
                   
                 endometrial alpha-2-globulin, alpha uterine protein) 
               
               
                   
                   
                   
                   
                 (PAEP), mRNA. /PROD = progestagen-associated 
               
               
                   
                   
                   
                   
                 endometrial protein(placental protein 14, pregnancy- 
               
               
                   
                   
                   
                   
                 associated endometrialalpha-2-globulin, alpha 
               
               
                   
                   
                   
                   
                 uterine protein) /FL = gb: NM_002571.1 gb: J04129.1 
               
               
                 210251_s_at 
                 −9.553 
                 Underexpressed 
                 RUFY3 
                 gb: AF112221.1 /DB_XREF = gi: 6563227 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 13 /TID = Hs.7972.1 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 5 /UG = Hs.7972 /LL = 22902 
               
               
                   
                   
                   
                   
                 /UG_GENE = KIAA0871 /DEF =  Homo sapiens  rap2 
               
               
                   
                   
                   
                   
                 interacting protein x mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = rap2 interacting protein x 
               
               
                   
                   
                   
                   
                 /FL = gb: AF112221.1 
               
               
                 202917_s_at 
                 13.185 
                 Overexpressed 
                 S100A8 
                 gb: NM_002964.2 /DB_XREF = gi: 9845519 
               
               
                   
                   
                   
                   
                 /GEN = S100A8 /FEA = FLmRNA /CNT = 257 
               
               
                   
                   
                   
                   
                 /TID = Hs.100000.0 /TIER = FL + Stack /STK = 93 
               
               
                   
                   
                   
                   
                 /UG = Hs.100000 /LL = 6279 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 S100 calcium-binding protein A8 (calgranulin A) 
               
               
                   
                   
                   
                   
                 (S100A8), mRNA. /PROD = S100 calcium-binding 
               
               
                   
                   
                   
                   
                 protein A8 /FL = gb: NM_002964.2 
               
               
                 1554276_at 
                 −13.803 
                 Underexpressed 
                 SART3 
                 gb: BC041638.1 /DB_XREF = gi: 27371321 
               
               
                   
                   
                   
                   
                 /TID = Hs2.116875.2 /CNT = 7 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 2 /LL = 9733 /UG_GENE = SART3 
               
               
                   
                   
                   
                   
                 /UG = Hs.116875 /DEF =  Homo sapiens , Similar to 
               
               
                   
                   
                   
                   
                 squamous cell carcinoma antigen recognised by T 
               
               
                   
                   
                   
                   
                 cells 3, clone MGC: 52127 IMAGE: 4844061, 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. /PROD = Similar to squamous 
               
               
                   
                   
                   
                   
                 cell carcinoma antigenrecognised by T cells 3 
               
               
                   
                   
                   
                   
                 /FL = gb: BC041638.1 
               
               
                 229839_at 
                 −8.3 
                 Underexpressed 
                 SCARA5 
                 gb: AI799784 /DB_XREF = gi: 5365256 
               
               
                   
                   
                   
                   
                 /DB_XREF = wc43b08.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2321367 /FEA = EST /CNT = 10 
               
               
                   
                   
                   
                   
                 /TID = Hs.49696.0 /TIER = Stack /STK = 9 
               
               
                   
                   
                   
                   
                 /UG = Hs.49696 /UG_TITLE = ESTs 
               
               
                 203789_s_at 
                 −8.419 
                 Underexpressed 
                 SEMA3C 
                 gb: NM_006379.1 /DB_XREF = gi: 5454047 
               
               
                   
                   
                   
                   
                 /GEN = SEMA3C /FEA = FLmRNA /CNT = 92 
               
               
                   
                   
                   
                   
                 /TID = Hs.171921.0 /TIER = FL + Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.171921 /LL = 10512 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 sema domain, immunoglobulin domain (Ig), short 
               
               
                   
                   
                   
                   
                 basic domain, secreted, (semaphorin) 3C (SEMA3C), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = sema domain, immunoglobulin 
               
               
                   
                   
                   
                   
                 domain (Ig), shortbasic domain, secreted, 
               
               
                   
                   
                   
                   
                 (semaphorin) 3C /FL = gb: NM_006379.1 
               
               
                   
                   
                   
                   
                 gb: AB000220.1 
               
               
                 230748_at 
                 −8.374 
                 Underexpressed 
                 SLC16A6 
                 gb: AI873273 /DB_XREF = gi: 5547322 
               
               
                   
                   
                   
                   
                 /DB_XREF = wf41c12.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2358166 /FEA = EST /CNT = 20 
               
               
                   
                   
                   
                   
                 /TID = Hs.42645.0 /TIER = Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.42645 /UG_TITLE = ESTs 
               
               
                 219911_s_at 
                 −8.586 
                 Underexpressed 
                 SLCO4A1 
                 gb: NM_016354.1 /DB_XREF = gi: 7706516 
               
               
                   
                   
                   
                   
                 /GEN = SLC21A12 /FEA = FLmRNA /CNT = 19 
               
               
                   
                   
                   
                   
                 /TID = Hs.235782.0 /TIER = FL /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.235782 /LL = 28231 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 solute carrier family 21 (organic anion transporter), 
               
               
                   
                   
                   
                   
                 member 12 (SLC21A12), mRNA. /PROD = organic 
               
               
                   
                   
                   
                   
                 anion transporter OATP-E /FL = gb: AB031051.1 
               
               
                   
                   
                   
                   
                 gb: NM_016354.1 gb: AF205072.1 gb: AF187817.1 
               
               
                 226403_at 
                 −8.969 
                 Underexpressed 
                 TMC4 
                 gb: BE645551 /DB_XREF = gi: 9969862 
               
               
                   
                   
                   
                   
                 /DB_XREF = 7e72b08.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3287991 /FEA = EST /CNT = 44 
               
               
                   
                   
                   
                   
                 /TID = Hs.112184.1 /TIER = Stack /STK = 27 
               
               
                   
                   
                   
                   
                 /UG = Hs.112184 /LL = 26173 
               
               
                   
                   
                   
                   
                 /UG_GENE = DKFZP586J0619 
               
               
                   
                   
                   
                   
                 /UG_TITLE = DKFZP586J0619 protein 
               
               
                 215108_x_at 
                 −8.953 
                 Underexpressed 
                 TNRC9 
                 gb: U80736.1 /DB_XREF = gi: 2565047 
               
               
                   
                   
                   
                   
                 /GEN = CAGF9 /FEA = mRNA /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.110826.1 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.110826 /LL = 27324 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 CAGF9 mRNA, partial cds. /PROD = CAGF9 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 Top Functions and Diseases in IPA associated with high priority genes of interest. 
               
             
          
           
               
                 Function and Disease 
                 −log(p- 
                   
               
               
                 Category 
                 value) 
                 Genes* 
               
               
                   
               
               
                 Cellular Movement 
                 1.31E−06-2.89E−02 
                 F11R, FN1, S100A8, PAEP, SEMA3C, IGFBP1, 
               
               
                   
                   
                 CCK, MMP12 
               
               
                 Hematological 
                 1.31E−06-2.82E−02 
                 F11R, FN1, S100A8, IGFBP1, PAEP, MMP12 
               
               
                 System Development 
               
               
                 and Function 
               
               
                 Cancer 
                 2.5E−06-2.89E−02 
                 KRT14, LRAP, FN1, EPAS1, FSTL3, CCK, PAEP, 
               
               
                   
                   
                 HPS3, F11R, S100A8, IGFBP1, SEMA3C, MMP12, 
               
               
                   
                   
                 CFHR1 
               
               
                 Immune Response 
                 4.11E−06-2.82E−02 
                 LRAP, F11R, FN1, S100A8, IGFBP1, PAEP, 
               
               
                   
                   
                 SEMA3C, 
               
               
                   
                   
                 MMP12, CFHR1 
               
               
                 Reproductive System 
                 4.81E−06-2.75E−02 
                 HPS3, EPAS1, FN1, FSTL3, S100A8, SEMA3C, 
               
               
                 Disease 
                   
                 PAEP, 
               
               
                   
                   
                 IGFBP1, ELL2 
               
               
                 Hematological 
                 3.83E−05-2.91E−02 
                 F11R, FN1, EPAS1, IGFBP1 
               
               
                 Disease 
               
               
                 Gastrointestinal 
                 6.36E−04-3.05E−02 
                 KRT14, LRAP, FN1, FSTL3, CCK, IGFBP1, CFHR1 
               
               
                 Disease 
               
               
                 Nutritional Disease 
                 7.52E−04-2.89E−02 
                 FN1, IGFBP1, CCK 
               
               
                 Reproductive System 
                 8.14E−04-2.26E−02 
                 EPAS1, FN1, IGFBP1 
               
               
                 Development 
               
               
                 and Function 
               
               
                 Embryonic 
                 1.56E−03-2.26E−02 
                 EPAS1, FN1, ASCL2, SEMA3C 
               
               
                 Development 
               
               
                   
               
               
                 Table created in IPA for genes of interest, Dec. 23, 2007 (Ingenuity 2007); 
               
               
                 *All genes are down-regulated except CCK and S100A8. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Functional groups other than immune incorporating 
               
               
                 IPA-omitted high priority genes of interest in PE. 
               
             
          
           
               
                   
                 Functional group 
                 Genes of Interest 
               
               
                   
                   
               
               
                   
                 Neural/Axonal 
                 CCK (Hansen et al., 2001; Hansen 
               
               
                   
                   
                 et al., 2007; Sodowski et al., 2007) 
               
               
                   
                   
                 SEMA3C (Baun et al., 2006; 
               
               
                   
                   
                 Gonthier et al., 2007) 
               
               
                   
                   
                 RUFY3 (Mori et al., 2007) 
               
               
                   
                   
                 ASCL2 (Westerman et al., 2002) 
               
               
                   
                   
                 DEPDC7 (Wong et al., 2000) 
               
               
                   
                 Imprinting 
                 CTAG2 (Lethe et al., 1998; Graves 
               
               
                   
                   
                 1998) 
               
               
                   
                   
                 ASCL (Miyamoto et al., 2002; 
               
               
                   
                   
                 Westerman et al., 2001) 
               
               
                   
                 Angiogenesis 
                 SEMA3C (Feiner et al., 2001) 
               
               
                   
                   
                 EPAS1 (Lelievre et al., 2001) 
               
               
                   
                   
                 PAEP (Song et al., 2001) 
               
               
                   
                   
                 CCK (Chao et al., 2007) 
               
               
                   
                   
                 FN1 (Kim et al., 2000) 
               
               
                   
                 VEGF related 
                 PAEP (Song et al., 2001) 
               
               
                   
                   
                 KRT14 (Kiba et al., 2003) 
               
               
                   
                   
                 FR11 (Kang et al., 2007) 
               
               
                   
                   
                 CCK (Chao et al., 2007) 
               
               
                   
                 Epithelium 
                 S100A8 (Wilkinson et al., 1988) 
               
               
                   
                   
                 PAEP (Jeschke et al., 2005) 
               
               
                   
                   
                 F11R (Table 9) 
               
               
                   
                   
                 MUC15 (Shyu et al., 2007) 
               
               
                   
                   
                 SCARA5 (Jiang et al., 2006) 
               
               
                   
                   
                 SCLO4A1 (Gao et al., 2005) 
               
               
                   
                   
                 KRT14 (Ma et al., 2001) 
               
               
                   
                   
                 LAIR2 (Xu et al., 2005) 
               
               
                   
                 Melanoma 
                 CTAG2 (Vaughan et al., 2004; 
               
               
                   
                   
                 Jungbluth et al., 2007) 
               
               
                   
                   
                 MAGEB (Jungbluth et al., 2007) 
               
               
                   
                   
                 LAIR2 (Xu et al., 2005) 
               
               
                   
                 Endothelium 
                 CCK HUVEC (Lefranc et al., 
               
               
                   
                   
                 2004) 
               
               
                   
                   
                 PAEP HUVEC (Song et al., 2001) 
               
               
                   
                   
                 LAIR2 (Xu et al., 2005) 
               
               
                   
                   
                 CFH (Manuelian et al., 2003) 
               
               
                   
                   
                 S100A8 (Sato et al., 1999) 
               
               
                   
                   
                 SEMA3C (Banu et al., 2006) 
               
               
                   
                   
                 EPAS1 (Sato et al., 2004) 
               
               
                   
                 Transcription factor 
                 ASCL2 
               
               
                   
                   
                 EPAS1 
               
               
                   
                   
                 TNRC9 
               
               
                   
                   
                 ELL2 
               
               
                   
                   
                 (all in Table 9) 
               
               
                   
                 Metabolic homeostasis 
                 CCK (Sodowski et al., 2007) 
               
               
                   
                 Insulin/glucose metabolism 
                 FSTL3 (Mukherjee et al., 2007) 
               
               
                   
                   
                 IGFBP1 (Table 9) 
               
               
                   
                   
                 EPAS1 (Wada 2007) 
               
               
                   
                   
                 SLCO4A1 (Fujiwara et al., 2005) 
               
               
                   
                   
                 SLC16A6 (Table 9) 
               
               
                   
                 Tyrosine kinase 
                 SEMA3C (Table 9) 
               
               
                   
                   
                 RUFY3 (Yang et al., 2002) 
               
               
                   
                   
                 FN1 (Table 9) 
               
               
                   
                 G protein-coupled receptor 
                 OXGR1 (Table 9) 
               
               
                   
                   
                 DEPDC7 (Wong et al., 2000) 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 Fold change data for CVS microarray 
               
             
          
           
               
                   
                   
                   
                 Condition in 
                   
               
               
                   
                 Fold 
                   
                 Preclampsia 
               
               
                 Probe ID 
                 Change 
                 Gene Symbols 
                 Group 
                 Target Description 
               
               
                   
               
             
          
           
               
                 236087_at 
                 2.22 
                 ABLIM2 
                 Overexpressed 
                 gb: AI912773 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5632628 
               
               
                   
                   
                   
                   
                 /DB_XREF = we13e06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2340994 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 9 
               
               
                   
                   
                   
                   
                 /TID = Hs.62648.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.62648 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 214358_at 
                 −2.12 
                 ACACA 
                 Underexpressed 
                 gb: AW188201 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6462637 
               
               
                   
                   
                   
                   
                 /DB_XREF = xj93f06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2664803 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.7232.1 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 8 /UG = Hs.7232 
               
               
                   
                   
                   
                   
                 /LL = 31 /UG_GENE = ACACA 
               
               
                   
                   
                   
                   
                 /UG_TITLE = acetyl- 
               
               
                   
                   
                   
                   
                 Coenzyme A carboxylase 
               
               
                   
                   
                   
                   
                 alpha 
               
               
                 236514_at 
                 2.09 
                 ACOT8 
                 Overexpressed 
                 gb: AI885067 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5590231 
               
               
                   
                   
                   
                   
                 /DB_XREF = wl89c05.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2432072 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 7 
               
               
                   
                   
                   
                   
                 /TID = Hs.6511.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 6 
               
               
                   
                   
                   
                   
                 /UG = Hs.6511 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 210929_s_at 
                 2.39 
                 AHSG 
                 Overexpressed 
                 gb: AF130057.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11493420 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.323288.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.323288 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  clone 
               
               
                   
                   
                   
                   
                 FLB5539 PRO1454 mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = PRO1454 
               
               
                   
                   
                   
                   
                 /FL = gb: AF130057.1 
               
               
                 207016_s_at 
                 −7.83 
                 ALDH1A2 
                 Underexpressed 
                 gb: AB015228.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 3970845 
               
               
                   
                   
                   
                   
                 /GEN = RALDH2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 10 
               
               
                   
                   
                   
                   
                 /TID = Hs.95197.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.95197 
               
               
                   
                   
                   
                   
                 /LL = 8854 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  mRNA for RALDH2- 
               
               
                   
                   
                   
                   
                 T, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = RALDH2-T 
               
               
                   
                   
                   
                   
                 /FL = gb: AB015228.1 
               
               
                   
                   
                   
                   
                 gb: AB015227.1 
               
               
                   
                   
                   
                   
                 gb: AB015226.1 
               
               
                   
                   
                   
                   
                 gb: NM_003888.1 
               
               
                 243276_at 
                 −2.19 
                 ALS2CL 
                 Underexpressed 
                 gb: AA557247 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2327724 
               
               
                   
                   
                   
                   
                 /DB_XREF = nl75e08.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1056518 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 6 
               
               
                   
                   
                   
                   
                 /TID = Hs.293637.1 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.293637 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 208323_s_at 
                 2.89 
                 ANXA13 
                 Overexpressed 
                 gb: NM_004306.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4757753 
               
               
                   
                   
                   
                   
                 /GEN = ANXA13 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.181107.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.181107 
               
               
                   
                   
                   
                   
                 /LL = 312 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 annexin A13 (ANXA13), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = annexin A13 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_004306.1 
               
               
                 203527_s_at 
                 −2.58 
                 APC 
                 Underexpressed 
                 gb: NM_000038.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4557318 
               
               
                   
                   
                   
                   
                 /GEN = APC /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 154 /TID = Hs.75081.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.75081 /LL = 324 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 adenomatosis polyposis coli 
               
               
                   
                   
                   
                   
                 (APC), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = adenomatosis 
               
               
                   
                   
                   
                   
                 polyposis coli 
               
               
                   
                   
                   
                   
                 /FL = gb: M74088.1 
               
               
                   
                   
                   
                   
                 gb: M73548.1 
               
               
                   
                   
                   
                   
                 gb: NM_000038.1 
               
               
                 206672_at 
                 −2.04 
                 AQP2 
                 Underexpressed 
                 gb: NM_000486.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4755122 
               
               
                   
                   
                   
                   
                 /GEN = AQP2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 26 
               
               
                   
                   
                   
                   
                 /TID = Hs.37025.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.37025 /LL = 359 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 aquaporin 2 (collecting duct) 
               
               
                   
                   
                   
                   
                 (AQP2), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = aquaporin 2 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000486.2 
               
               
                 239373_at 
                 3.41 
                 ARFGEF2 
                 Overexpressed 
                 gb: AI034357 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 3255310 
               
               
                   
                   
                   
                   
                 /DB_XREF = ox20e11.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1656908 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 7 
               
               
                   
                   
                   
                   
                 /TID = Hs.211194.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.211194 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs, Weakly 
               
               
                   
                   
                   
                   
                 similar to ALU8_HUMAN 
               
               
                   
                   
                   
                   
                 ALU SUBFAMILY SX 
               
               
                   
                   
                   
                   
                 SEQUENCE 
               
               
                   
                   
                   
                   
                 CONTAMINATION 
               
               
                   
                   
                   
                   
                 WARNING ENTRY 
               
               
                   
                   
                   
                   
                 ( H. sapiens ) 
               
               
                 207919_at 
                 −2.2 
                 ART1 
                 Underexpressed 
                 gb: NM_004314.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4757783 
               
               
                   
                   
                   
                   
                 /GEN = ART1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.73139.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.73139 
               
               
                   
                   
                   
                   
                 /LL = 417 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 ADP-ribosyltransferase 1 
               
               
                   
                   
                   
                   
                 (ART1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = ADP- 
               
               
                   
                   
                   
                   
                 ribosyltransferase 1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_004314.1 
               
               
                 229215_at 
                 −2.15 
                 ASCL2 
                 Underexpressed 
                 gb: AI393930 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4223477 
               
               
                   
                   
                   
                   
                 /DB_XREF = tg11a01.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2108424 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.152475.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 8 
               
               
                   
                   
                   
                   
                 /UG = Hs.152475 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 233796_at 
                 2.23 
                 ATP7B 
                 Overexpressed 
                 gb: AK002066.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7023723 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.296547.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.296547 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 cDNA FLJ11204 fis, clone 
               
               
                   
                   
                   
                   
                 PLACE1007810 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  cDNA FLJ11204 fis, 
               
               
                   
                   
                   
                   
                 clone PLACE1007810. 
               
               
                 212849_at 
                 −2.17 
                 AXIN1 
                 Underexpressed 
                 gb: AA745954 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2785940 
               
               
                   
                   
                   
                   
                 /DB_XREF = ob18e04.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1324062 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 72 
               
               
                   
                   
                   
                   
                 /TID = Hs.184434.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 33 
               
               
                   
                   
                   
                   
                 /UG = Hs.184434 /LL = 8312 
               
               
                   
                   
                   
                   
                 /UG_GENE = AXIN1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = axin 
               
               
                 205870_at 
                 −2.7 
                 BDKRB2 
                 Underexpressed 
                 gb: NM_000623.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4557358 
               
               
                   
                   
                   
                   
                 /GEN = BDKRB2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 34 
               
               
                   
                   
                   
                   
                 /TID = Hs.250882.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.250882 /LL = 624 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 bradykinin receptor B2 
               
               
                   
                   
                   
                   
                 (BDKRB2), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = bradykinin receptor 
               
               
                   
                   
                   
                   
                 B2 /FL = gb: M88714.1 
               
               
                   
                   
                   
                   
                 gb: NM_000623.1 
               
               
                 204741_at 
                 2.19 
                 BICD1 
                 Overexpressed 
                 gb: NM_001714.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4502408 
               
               
                   
                   
                   
                   
                 /GEN = BICD1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 47 
               
               
                   
                   
                   
                   
                 /TID = Hs.164975.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.164975 /LL = 636 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  Bicaudal 
               
               
                   
                   
                   
                   
                 D ( Drosophila ) homolog 1 
               
               
                   
                   
                   
                   
                 (BICD1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = Bicaudal D 
               
               
                   
                   
                   
                   
                 ( Drosophila ) homolog 1 
               
               
                   
                   
                   
                   
                 /FL = gb: U90028.1 
               
               
                   
                   
                   
                   
                 gb: NM_001714.1 
               
               
                 217767_at 
                 −3.28 
                 C3 
                 Underexpressed 
                 gb: NM_000064.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4557384 
               
               
                   
                   
                   
                   
                 /GEN = C3 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 473 /TID = Hs.284394.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 213 
               
               
                   
                   
                   
                   
                 /UG = Hs.284394 /LL = 718 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 complement component 3 
               
               
                   
                   
                   
                   
                 (C3), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = complement 
               
               
                   
                   
                   
                   
                 component 3 precursor 
               
               
                   
                   
                   
                   
                 /FL = gb: K02765.1 
               
               
                   
                   
                   
                   
                 gb: NM_000064.1 
               
               
                 205654_at 
                 −2.67 
                 C4BPA 
                 Underexpressed 
                 gb: NM_000715.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4502502 
               
               
                   
                   
                   
                   
                 /GEN = C4BPA 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 53 
               
               
                   
                   
                   
                   
                 /TID = Hs.1012.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 22 
               
               
                   
                   
                   
                   
                 /UG = Hs.1012 /LL = 722 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 complement component 4- 
               
               
                   
                   
                   
                   
                 binding protein, alpha 
               
               
                   
                   
                   
                   
                 (C4BPA), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = complement 
               
               
                   
                   
                   
                   
                 component 4-binding protein, 
               
               
                   
                   
                   
                   
                 alpha /FL = gb: NM_000715.1 
               
               
                   
                   
                   
                   
                 gb: M31452.1 
               
               
                 205827_at 
                 4.46 
                 CCK 
                 Overexpressed 
                 gb: NM_000729.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4755130 
               
               
                   
                   
                   
                   
                 /GEN = CCK /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 40 /TID = Hs.80247.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 23 
               
               
                   
                   
                   
                   
                 /UG = Hs.80247 /LL = 885 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 cholecystokinin (CCK), 
               
               
                   
                   
                   
                   
                 mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = cholecystokinin 
               
               
                   
                   
                   
                   
                 preproprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000729.2 
               
               
                 34210_at 
                 2.42 
                 CD52 
                 Overexpressed 
                 Cluster Incl. 
               
               
                   
                   
                   
                   
                 N90866: zb11b10.s1  Homo   
               
               
                   
                   
                   
                   
                   sapiens  cDNA, 3 end 
               
               
                   
                   
                   
                   
                 /clone = IMAGE-301723 
               
               
                   
                   
                   
                   
                 /clone_end = 3′ /gb = N90866 
               
               
                   
                   
                   
                   
                 /gi = 1444193 /ug = Hs.214742 
               
               
                   
                   
                   
                   
                 /len = 577 
               
               
                 206328_at 
                 7.67 
                 CDH15 
                 Overexpressed 
                 gb: NM_004933.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4826668 
               
               
                   
                   
                   
                   
                 /GEN = CDH15 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 32 
               
               
                   
                   
                   
                   
                 /TID = Hs.148090.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 6 /UG = Hs.148090 
               
               
                   
                   
                   
                   
                 /LL = 1013 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  cadherin 15, M- 
               
               
                   
                   
                   
                   
                 cadherin (myotubule) 
               
               
                   
                   
                   
                   
                 (CDH15), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = cadherin 15, M- 
               
               
                   
                   
                   
                   
                 cadherin (myotubule) 
               
               
                   
                   
                   
                   
                 /FL = gb: D83542.1 
               
               
                   
                   
                   
                   
                 gb: NM_004933.1 
               
               
                 239026_x_at 
                 −2.68 
                 CENTG3 
                 Underexpressed 
                 gb: H20019 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 888714 
               
               
                   
                   
                   
                   
                 /DB_XREF = yn55c04.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 172326 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.148415.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.148415 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 215388_s_at 
                 −3.48 
                 CFHR1 
                 Underexpressed 
                 gb: X56210.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 30132 
               
               
                   
                   
                   
                   
                 /GEN = H 36-2 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /CNT = 4 /TID = Hs.296941.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.296941 /LL = 3079 
               
               
                   
                   
                   
                   
                 /DEF =  H. sapiens  mRNA for 
               
               
                   
                   
                   
                   
                 complement Factor H-related 
               
               
                   
                   
                   
                   
                 protein 1, clone H 36-2. 
               
               
                   
                   
                   
                   
                 /PROD = FHR-1; complement 
               
               
                   
                   
                   
                   
                 Factor H-related protein 1 
               
               
                 1568704_a_at 
                 −3.76 
                 CHERP 
                 Underexpressed 
                 gb: BF511683 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11594981 
               
               
                   
                   
                   
                   
                 /DB_XREF = UI-H-BI4-aom- 
               
               
                   
                   
                   
                   
                 c-07-0-UI.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3085428 
               
               
                   
                   
                   
                   
                 /TID = Hs2.300452.1 /CNT = 9 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.300452 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 Similar to calcium 
               
               
                   
                   
                   
                   
                 homeostasis endoplasmic 
               
               
                   
                   
                   
                   
                 reticulum protein, clone 
               
               
                   
                   
                   
                   
                 IMAGE: 4827033, mRNA 
               
               
                   
                   
                   
                   
                 (Probes match on alternative 
               
               
                   
                   
                   
                   
                 forms of same gene) 
               
               
                 209763_at 
                 −7.34 
                 CHRDL1 
                 Underexpressed 
                 gb: AL049176 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4808226 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 84 
               
               
                   
                   
                   
                   
                 /TID = Hs.82223.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 46 
               
               
                   
                   
                   
                   
                 /UG = Hs.82223 /LL = 57803 
               
               
                   
                   
                   
                   
                 /UG_GENE = LOC57803 
               
               
                   
                   
                   
                   
                 /UG_TITLE = chordin-like 
               
               
                   
                   
                   
                   
                 /DEF = Human DNA sequence 
               
               
                   
                   
                   
                   
                 from clone 141H5 on 
               
               
                   
                   
                   
                   
                 chromosome Xq22.1-23. 
               
               
                   
                   
                   
                   
                 Contains parts of a novel 
               
               
                   
                   
                   
                   
                 Chordin LIKE protein with 
               
               
                   
                   
                   
                   
                 von Willebrand factor type C 
               
               
                   
                   
                   
                   
                 domains. Contains ESTs, 
               
               
                   
                   
                   
                   
                 STSs and GSSs 
               
               
                   
                   
                   
                   
                 /FL = gb: BC002909.1 
               
               
                 223786_at 
                 −2.21 
                 CHST6 
                 Underexpressed 
                 gb: AF280086.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 12060803 
               
               
                   
                   
                   
                   
                 /GEN = GST4beta 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 9 
               
               
                   
                   
                   
                   
                 /TID = Hs.157439.1 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.157439 
               
               
                   
                   
                   
                   
                 /LL = 4166 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  N-acetylglucosamine 
               
               
                   
                   
                   
                   
                 6-O-sulfotransferase GST- 
               
               
                   
                   
                   
                   
                 4beta mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = N-acetylglucosamine 
               
               
                   
                   
                   
                   
                 6-O-sulfotransferaseGST- 
               
               
                   
                   
                   
                   
                 4beta /FL = gb: AF280086.1 
               
               
                 1555469_a_at 
                 −2.1 
                 CLASP2 
                 Underexpressed 
                 gb: BC029035.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 20810064 
               
               
                   
                   
                   
                   
                 /TID = Hs2.108614.1 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /LL = 23122 
               
               
                   
                   
                   
                   
                 /UG_GENE = CLASP2 
               
               
                   
                   
                   
                   
                 /UG = Hs.108614 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens , Similar to CLIP- 
               
               
                   
                   
                   
                   
                 associating protein 2, clone 
               
               
                   
                   
                   
                   
                 MGC: 35497 
               
               
                   
                   
                   
                   
                 IMAGE: 5197008, mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. /PROD = Similar 
               
               
                   
                   
                   
                   
                 to CLIP-associating protein 2 
               
               
                   
                   
                   
                   
                 /FL = gb: BC029035.1 (Probes 
               
               
                   
                   
                   
                   
                 match on alternative forms of 
               
               
                   
                   
                   
                   
                 same gene) 
               
               
                 209235_at 
                 −2.13 
                 CLCN7 
                 Underexpressed 
                 gb: AL031600 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4826481 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 184 
               
               
                   
                   
                   
                   
                 /TID = Hs.80768.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 75 
               
               
                   
                   
                   
                   
                 /UG = Hs.80768 /LL = 1186 
               
               
                   
                   
                   
                   
                 /UG_GENE = CLCN7 
               
               
                   
                   
                   
                   
                 /UG_TITLE = chloride channel 
               
               
                   
                   
                   
                   
                 7 /DEF = Human DNA 
               
               
                   
                   
                   
                   
                 sequence from clone 390E6 
               
               
                   
                   
                   
                   
                 on chromosome 16. Contains 
               
               
                   
                   
                   
                   
                 the 3 part of the CLCN7 gene 
               
               
                   
                   
                   
                   
                 for chloride channel 7, ESTs, 
               
               
                   
                   
                   
                   
                 a GSS and four putative CpG 
               
               
                   
                   
                   
                   
                 islands /FL = gb: AF224741.1 
               
               
                 237810_at 
                 −2.15 
                 CLDN6 
                 Underexpressed 
                 gb: AW003929 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5850845 
               
               
                   
                   
                   
                   
                 /DB_XREF = wq84d05.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2478729 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 6 
               
               
                   
                   
                   
                   
                 /TID = Hs.198684.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 6 
               
               
                   
                   
                   
                   
                 /UG = Hs.198684 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 213818_x_at 
                 2.12 
                 COL5A1 
                 Overexpressed 
                 gb: AI862325 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5526432 
               
               
                   
                   
                   
                   
                 /DB_XREF = tw71h04.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2265175 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 23 
               
               
                   
                   
                   
                   
                 /TID = Hs.146428.3 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 19 
               
               
                   
                   
                   
                   
                 /UG = Hs.146428 /LL = 1289 
               
               
                   
                   
                   
                   
                 /UG_GENE = COL5A1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = collagen, type 
               
               
                   
                   
                   
                   
                 V, alpha 1 
               
               
                 204724_s_at 
                 2.41 
                 COL9A3 
                 Overexpressed 
                 gb: NM_001853.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4502966 
               
               
                   
                   
                   
                   
                 /GEN = COL9A3 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 331 
               
               
                   
                   
                   
                   
                 /TID = Hs.53563.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 14 
               
               
                   
                   
                   
                   
                 /UG = Hs.53563 /LL = 1299 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  collagen, 
               
               
                   
                   
                   
                   
                 type IX, alpha 3 (COL9A3), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = collagen, 
               
               
                   
                   
                   
                   
                 type IX, alpha 3 
               
               
                   
                   
                   
                   
                 /FL = gb: L41162.1 
               
               
                   
                   
                   
                   
                 gb: NM_001853.1 
               
               
                 235019_at 
                 −2.06 
                 CPM 
                 Underexpressed 
                 gb: BE878495 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10327271 
               
               
                   
                   
                   
                   
                 /DB_XREF = 601492515F1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3894722 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 32 
               
               
                   
                   
                   
                   
                 /TID = Hs.267158.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.267158 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 217552_x_at 
                 2 
                 CR1 
                 Overexpressed 
                 gb: AI432713 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4283899 
               
               
                   
                   
                   
                   
                 /DB_XREF = th43e02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2121050 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 5 
               
               
                   
                   
                   
                   
                 /TID = Hs.241053.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 
               
               
                   
                   
                   
                   
                 /UG = Hs.241053 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206185_at 
                 −2.05 
                 CRYBB1 
                 Underexpressed 
                 gb: NM_001887.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4503060 
               
               
                   
                   
                   
                   
                 /GEN = CRYBB1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 41 
               
               
                   
                   
                   
                   
                 /TID = Hs.37135.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 7 /UG = Hs.37135 
               
               
                   
                   
                   
                   
                 /LL = 1414 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  crystallin, beta B1 
               
               
                   
                   
                   
                   
                 (CRYBB1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = crystallin, beta B1 
               
               
                   
                   
                   
                   
                 /FL = gb: U35340.1 
               
               
                   
                   
                   
                   
                 gb: NM_001887.1 
               
               
                 243286_at 
                 −2.01 
                 CUL1 
                 Underexpressed 
                 gb: AA682674 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2669955 
               
               
                   
                   
                   
                   
                 /DB_XREF = zj20h10.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 450883 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 6 
               
               
                   
                   
                   
                   
                 /TID = Hs.140498.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.140498 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 1554837_a_at 
                 −2.38 
                 CYP4A11(includes 
                 Underexpressed 
                 gb: BC041158.1 
               
               
                   
                   
                 EG: 1579) 
                   
                 /DB_XREF = gi: 27552844 
               
               
                   
                   
                   
                   
                 /TID = Hs2.1645.2 /CNT = 3 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /LL = 1579 
               
               
                   
                   
                   
                   
                 /UG_GENE = CYP4A11 
               
               
                   
                   
                   
                   
                 /UG = Hs.1645 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens , Similar to 
               
               
                   
                   
                   
                   
                 cytochrome P450, subfamily 
               
               
                   
                   
                   
                   
                 IVA, polypeptide 11, clone 
               
               
                   
                   
                   
                   
                 MGC: 48730 
               
               
                   
                   
                   
                   
                 IMAGE: 5183289, mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. /PROD = Similar 
               
               
                   
                   
                   
                   
                 to cytochrome P450, 
               
               
                   
                   
                   
                   
                 subfamily IVA, polypeptide 11 
               
               
                   
                   
                   
                   
                 /FL = gb: BC041158.1 (Probes 
               
               
                   
                   
                   
                   
                 match on alternative forms of 
               
               
                   
                   
                   
                   
                 same gene) 
               
               
                 203915_at 
                 2.07 
                 CXCL9 
                 Overexpressed 
                 gb: NM_002416.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505186 
               
               
                   
                   
                   
                   
                 /GEN = MIG /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 103 /TID = Hs.77367.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 38 
               
               
                   
                   
                   
                   
                 /UG = Hs.77367 /LL = 4283 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 monokine induced by gamma 
               
               
                   
                   
                   
                   
                 interferon (MIG), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = monokine induced by 
               
               
                   
                   
                   
                   
                 gamma interferon 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002416.1 
               
               
                 214079_at 
                 −2.77 
                 DHRS2 (includes 
                 Underexpressed 
                 gb: AK000345.1 
               
               
                   
                   
                 EG: 10202) 
                   
                 /DB_XREF = gi: 7020368 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 16 
               
               
                   
                   
                   
                   
                 /TID = Hs.152677.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 12 
               
               
                   
                   
                   
                   
                 /UG = Hs.152677 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 cDNA FLJ20338 fis, clone 
               
               
                   
                   
                   
                   
                 HEP12179 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  cDNA FLJ20338 fis, 
               
               
                   
                   
                   
                   
                 clone HEP12179. 
               
               
                 1568736_s_at 
                 −4.42 
                 DLGAP1 
                 Underexpressed 
                 gb: BC030096.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 22535265 
               
               
                   
                   
                   
                   
                 /TID = Hs2.371203.1 /CNT = 5 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.371203 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 4795078, 
               
               
                   
                   
                   
                   
                 mRNA /DEF =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 4795078, 
               
               
                   
                   
                   
                   
                 mRNA. (All probes match 
               
               
                   
                   
                   
                   
                 over all sequences) 
               
               
                 205493_s_at 
                 2.01 
                 DPYSL4 
                 Overexpressed 
                 gb: NM_006426.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11321616 
               
               
                   
                   
                   
                   
                 /GEN = DPYSL4 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 29 
               
               
                   
                   
                   
                   
                 /TID = Hs.100058.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /UG = Hs.100058 
               
               
                   
                   
                   
                   
                 /LL = 10570 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  dihydropyrimidinase- 
               
               
                   
                   
                   
                   
                 like 4 (DPYSL4), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = dihydropyrimidinase- 
               
               
                   
                   
                   
                   
                 like 4 /FL = gb: NM_006426.1 
               
               
                   
                   
                   
                   
                 gb: AB006713.1 
               
               
                 222847_s_at 
                 −2.06 
                 EGLN3 
                 Underexpressed 
                 gb: AI378406 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4188259 
               
               
                   
                   
                   
                   
                 /DB_XREF = tc78g03.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2070772 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 47 
               
               
                   
                   
                   
                   
                 /TID = Hs.18878.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.18878 /LL = 63900 
               
               
                   
                   
                   
                   
                 /UG_GENE = FLJ21620 
               
               
                   
                   
                   
                   
                 /UG_TITLE = hypothetical 
               
               
                   
                   
                   
                   
                 protein FLJ21620 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_022073.1 
               
               
                 227404_s_at 
                 2.37 
                 EGR1 
                 Overexpressed 
                 gb: AI459194 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4311773 
               
               
                   
                   
                   
                   
                 /DB_XREF = tj54g06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2145370 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 42 
               
               
                   
                   
                   
                   
                 /TID = Hs.326035.1 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 26 
               
               
                   
                   
                   
                   
                 /UG = Hs.326035 /LL = 1958 
               
               
                   
                   
                   
                   
                 /UG_GENE = EGR1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = early growth 
               
               
                   
                   
                   
                   
                 response 1 
               
               
                 235592_at 
                 −4.02 
                 ELL2 
                 Underexpressed 
                 gb: AW960145 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 8149829 
               
               
                   
                   
                   
                   
                 /DB_XREF = EST372216 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 12 
               
               
                   
                   
                   
                   
                 /TID = Hs.100636.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.100636 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 242868_at 
                 −7.64 
                 EPAS1 
                 Underexpressed 
                 gb: T70087 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 681235 
               
               
                   
                   
                   
                   
                 /DB_XREF = yc17g11.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 80996 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 7 
               
               
                   
                   
                   
                   
                 /TID = Hs.307559.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.307559 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 203989_x_at 
                 −2.98 
                 F2R 
                 Underexpressed 
                 gb: NM_001992.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6031164 
               
               
                   
                   
                   
                   
                 /GEN = F2R /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 74 /TID = Hs.128087.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.128087 /LL = 2149 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 coagulation factor II 
               
               
                   
                   
                   
                   
                 (thrombin) receptor (F2R), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = coagulation 
               
               
                   
                   
                   
                   
                 factor II receptor precursor 
               
               
                   
                   
                   
                   
                 /FL = gb: M62424.1 
               
               
                   
                   
                   
                   
                 gb: BC002464.1 
               
               
                   
                   
                   
                   
                 gb: NM_001992.2 
               
               
                 239248_at 
                 2.1 
                 FKBP1A 
                 Overexpressed 
                 gb: BE742802 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10156794 
               
               
                   
                   
                   
                   
                 /DB_XREF = 601574420F1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3835445 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 11 
               
               
                   
                   
                   
                   
                 /TID = Hs.189696.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.189696 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 204358_s_at 
                 2.2 
                 FLRT2 
                 Overexpressed 
                 gb: AF169676.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6808604 
               
               
                   
                   
                   
                   
                 /GEN = FLRT2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 86 
               
               
                   
                   
                   
                   
                 /TID = Hs.48998.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.48998 /LL = 23768 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  leucine- 
               
               
                   
                   
                   
                   
                 rich repeat transmembrane 
               
               
                   
                   
                   
                   
                 protein FLRT2 (FLRT2) 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = leucine-rich repeat 
               
               
                   
                   
                   
                   
                 transmembrane protein 
               
               
                   
                   
                   
                   
                 FLRT2 /FL = gb: AB007865.1 
               
               
                   
                   
                   
                   
                 gb: AF169676.1 
               
               
                   
                   
                   
                   
                 gb: NM_013231.1 
               
               
                 229902_at 
                 −2.12 
                 FLT4 
                 Underexpressed 
                 gb: AW083785 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6038937 
               
               
                   
                   
                   
                   
                 /DB_XREF = xc35b04.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2586223 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 14 
               
               
                   
                   
                   
                   
                 /TID = Hs.8941.0 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 11 /UG = Hs.8941 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 214702_at 
                 −2.35 
                 FN1 
                 Underexpressed 
                 gb: AJ276395.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 12053816 
               
               
                   
                   
                   
                   
                 /GEN = FN /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /CNT = 52 /TID = Hs.321592.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 
               
               
                   
                   
                   
                   
                 /UG = Hs.321592 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  mRNA for MSF- 
               
               
                   
                   
                   
                   
                 FN70 (FN gene). 
               
               
                   
                   
                   
                   
                 /PROD = migration stimulation 
               
               
                   
                   
                   
                   
                 factor FN70 
               
               
                 209189_at 
                 2.78 
                 FOS 
                 Overexpressed 
                 gb: BC004490.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 13325363 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 139 
               
               
                   
                   
                   
                   
                 /TID = Hs.25647.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.25647 
               
               
                   
                   
                   
                   
                 /LL = 2353 /UG_GENE = FOS 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens , v-fos 
               
               
                   
                   
                   
                   
                 FBJ murine osteosarcoma 
               
               
                   
                   
                   
                   
                 viral oncogene homolog, 
               
               
                   
                   
                   
                   
                 clone MGC: 11074, mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. /PROD = v-fos 
               
               
                   
                   
                   
                   
                 FBJ murine osteosarcoma 
               
               
                   
                   
                   
                   
                 viral oncogenehomolog 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_005252.2 
               
               
                   
                   
                   
                   
                 gb: BC004490.1 
               
               
                 202768_at 
                 2.33 
                 FOSB 
                 Overexpressed 
                 gb: NM_006732.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5803016 
               
               
                   
                   
                   
                   
                 /GEN = FOSB 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 167 
               
               
                   
                   
                   
                   
                 /TID = Hs.75678.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 67 
               
               
                   
                   
                   
                   
                 /UG = Hs.75678 /LL = 2354 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  FBJ 
               
               
                   
                   
                   
                   
                 murine osteosarcoma viral 
               
               
                   
                   
                   
                   
                 oncogene homolog B (FOSB), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = FBJ murine 
               
               
                   
                   
                   
                   
                 osteosarcoma viral oncogene 
               
               
                   
                   
                   
                   
                 homologB 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006732.1 
               
               
                   
                   
                   
                   
                 gb: L49169.1 
               
               
                 214560_at 
                 2 
                 FPRL2 
                 Overexpressed 
                 gb: NM_002030.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4758401 
               
               
                   
                   
                   
                   
                 /GEN = FPRL2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.158314.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.158314 
               
               
                   
                   
                   
                   
                 /LL = 2359 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  formyl peptide 
               
               
                   
                   
                   
                   
                 receptor-like 2 (FPRL2), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = formyl 
               
               
                   
                   
                   
                   
                 peptide receptor-like 2 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002030.2 
               
               
                   
                   
                   
                   
                 gb: M76673.1 
               
               
                 203592_s_at 
                 −2.56 
                 FSTL3 
                 Underexpressed 
                 gb: NM_005860.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5031700 
               
               
                   
                   
                   
                   
                 /GEN = FSTL3 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 129 
               
               
                   
                   
                   
                   
                 /TID = Hs.25348.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 33 
               
               
                   
                   
                   
                   
                 /UG = Hs.25348 /LL = 10272 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 follistatin-like 3 (secreted 
               
               
                   
                   
                   
                   
                 glycoprotein) (FSTL3), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = follistatin- 
               
               
                   
                   
                   
                   
                 like 3 glycoprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: U76702.1 
               
               
                   
                   
                   
                   
                 gb: NM_005860.1 
               
               
                 1565661_x_at 
                 2.02 
                 FUT6 
                 Overexpressed 
                 gb: BC040472.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 26251793 
               
               
                   
                   
                   
                   
                 /TID = Hs2.434404.1 /CNT = 6 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.434404 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 4557161, 
               
               
                   
                   
                   
                   
                 mRNA /DEF =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 4557161, 
               
               
                   
                   
                   
                   
                 mRNA (Probes cross hyb with 
               
               
                   
                   
                   
                   
                 other sequences) 
               
               
                 206136_at 
                 2.24 
                 FZD5 
                 Overexpressed 
                 gb: NM_003468.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4503828 
               
               
                   
                   
                   
                   
                 /GEN = FZD5 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 19 /TID = Hs.152251.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.152251 /LL = 7855 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  frizzled 
               
               
                   
                   
                   
                   
                 ( Drosophila ) homolog 5 
               
               
                   
                   
                   
                   
                 (FZD5), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = frizzled 5 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_003468.1 
               
               
                   
                   
                   
                   
                 gb: U43318.1 
               
               
                 1555590_a_at 
                 −2.47 
                 GATA1 
                 Underexpressed 
                 gb: BC009797.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 14602570 
               
               
                   
                   
                   
                   
                 /TID = Hs2.765.2 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /LL = 2623 
               
               
                   
                   
                   
                   
                 /UG_GENE = GATA1 
               
               
                   
                   
                   
                   
                 /UG = Hs.765 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens , GATA-binding 
               
               
                   
                   
                   
                   
                 protein 1 (globin transcription 
               
               
                   
                   
                   
                   
                 factor 1), clone MGC: 13628 
               
               
                   
                   
                   
                   
                 IMAGE: 4048082, mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = GATA-binding 
               
               
                   
                   
                   
                   
                 protein 1 (globin 
               
               
                   
                   
                   
                   
                 transcriptionfactor 1) 
               
               
                   
                   
                   
                   
                 /FL = gb: BC009797.1 (Probes 
               
               
                   
                   
                   
                   
                 match on alternative forms of 
               
               
                   
                   
                   
                   
                 same gene) 
               
               
                 1555765_a_at 
                 −3.73 
                 GNG4 
                 Underexpressed 
                 gb: AF493872.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 20147636 
               
               
                   
                   
                   
                   
                 /GEN = GNG4 
               
               
                   
                   
                   
                   
                 /TID = Hs2.32976.3 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /LL = 2786 
               
               
                   
                   
                   
                   
                 /UG = Hs.32976 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  guanine nucleotide 
               
               
                   
                   
                   
                   
                 binding protein gamma 4 
               
               
                   
                   
                   
                   
                 (GNG4) mRNA, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = guanine 
               
               
                   
                   
                   
                   
                 nucleotide binding protein 
               
               
                   
                   
                   
                   
                 gamma 4 /FL = gb: AF493872.1 
               
               
                   
                   
                   
                   
                 (Probes match on alternative 
               
               
                   
                   
                   
                   
                 forms of same gene) 
               
               
                 232043_at 
                 −2.67 
                 GNG7 
                 Underexpressed 
                 gb: AA890272 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 3017151 
               
               
                   
                   
                   
                   
                 /DB_XREF = aj96e12.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1404334 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 14 
               
               
                   
                   
                   
                   
                 /TID = Hs.6750.1 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.6750 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 mRNA for FLJ00058 protein, 
               
               
                   
                   
                   
                   
                 partial cds 
               
               
                 205495_s_at 
                 −23.51 
                 GNLY 
                 Underexpressed 
                 gb: NM_006433.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7108343 
               
               
                   
                   
                   
                   
                 /GEN = GNLY 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 32 
               
               
                   
                   
                   
                   
                 /TID = Hs.105806.1 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.105806 /LL = 10578 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 granulysin (GNLY), transcript 
               
               
                   
                   
                   
                   
                 variant NKG5, mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = granulysin, isoform 
               
               
                   
                   
                   
                   
                 NKG5 /FL = gb: NM_006433.2 
               
               
                 205220_at 
                 −2.63 
                 GPR109B 
                 Underexpressed 
                 gb: NM_006018.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5174460 
               
               
                   
                   
                   
                   
                 /GEN = HM74 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 40 
               
               
                   
                   
                   
                   
                 /TID = Hs.137555.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.137555 /LL = 8843 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  putative 
               
               
                   
                   
                   
                   
                 chemokine receptor; GTP- 
               
               
                   
                   
                   
                   
                 binding protein (HM74), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = putative 
               
               
                   
                   
                   
                   
                 chemokine receptor; GTP- 
               
               
                   
                   
                   
                   
                 bindingprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006018.1 
               
               
                 223789_s_at 
                 −2.17 
                 GTPBP2 
                 Underexpressed 
                 gb: AF116627.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7959755 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.183698.1 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.183698 
               
               
                   
                   
                   
                   
                 /LL = 6159 
               
               
                   
                   
                   
                   
                 /UG_GENE = RPL29 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 PRO1181 mRNA, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = PRO1181 
               
               
                   
                   
                   
                   
                 /FL = gb: AF116627.1 
               
               
                 210164_at 
                 −2.7 
                 GZMB 
                 Underexpressed 
                 gb: J03189.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 338010 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 28 
               
               
                   
                   
                   
                   
                 /TID = Hs.1051.1 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 11 
               
               
                   
                   
                   
                   
                 /UG = Hs.1051 /LL = 3002 
               
               
                   
                   
                   
                   
                 /UG_GENE = GZMB 
               
               
                   
                   
                   
                   
                 /UG_TITLE = granzyme B 
               
               
                   
                   
                   
                   
                 (granzyme 2, cytotoxic T- 
               
               
                   
                   
                   
                   
                 lymphocyte-associated serine 
               
               
                   
                   
                   
                   
                 esterase 1) /DEF = Human 
               
               
                   
                   
                   
                   
                 proteolytic serine esterase-like 
               
               
                   
                   
                   
                   
                 protein (SECT) gene, 
               
               
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                   
                   
                 /FL = gb: M17016.1 
               
               
                   
                   
                   
                   
                 gb: J03189.1 gb: NM_004131.2 
               
               
                   
                   
                   
                   
                 gb: J04071.1 
               
               
                 205919_at 
                 −2.64 
                 HBE1 
                 Underexpressed 
                 gb: NM_005330.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6715605 
               
               
                   
                   
                   
                   
                 /GEN = HBE1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 48 
               
               
                   
                   
                   
                   
                 /TID = Hs.117848.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.117848 /LL = 3046 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 hemoglobin, epsilon 1 
               
               
                   
                   
                   
                   
                 (HBE1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = hemoglobin, epsilon 
               
               
                   
                   
                   
                   
                 1 /FL = gb: NM_005330.2 
               
               
                 206647_at 
                 −6.51 
                 HBZ 
                 Underexpressed 
                 gb: NM_005332.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6633805 
               
               
                   
                   
                   
                   
                 /GEN = HBZ /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 36 /TID = Hs.272003.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.272003 /LL = 3050 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 hemoglobin, zeta (HBZ), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = hemoglobin, 
               
               
                   
                   
                   
                   
                 zeta /FL = gb: NM_005332.2 
               
               
                   
                   
                   
                   
                 gb: M24173.1 
               
               
                 202473_x_at 
                 2.17 
                 HCFC1 
                 Overexpressed 
                 gb: AA703045 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2706158 
               
               
                   
                   
                   
                   
                 /DB_XREF = zi74d09.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 436529 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 143 
               
               
                   
                   
                   
                   
                 /TID = Hs.83634.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 12 
               
               
                   
                   
                   
                   
                 /UG = Hs.83634 /LL = 3054 
               
               
                   
                   
                   
                   
                 /UG_GENE = HCFC1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = host cell factor 
               
               
                   
                   
                   
                   
                 C1 (VP16-accessory protein) 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_005334.1 
               
               
                 1556426_at 
                 2.46 
                 HEXA 
                 Overexpressed 
                 gb: BC034424.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 21706987 
               
               
                   
                   
                   
                   
                 /TID = Hs2.166299.1 /CNT = 8 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.166299 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 4823589, 
               
               
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens , clone 
               
               
                   
                   
                   
                   
                 IMAGE: 4823589, mRNA, 
               
               
                   
                   
                   
                   
                 partial cds. 
               
               
                 203290_at 
                 2.21 
                 HLA-DQA1 
                 Overexpressed 
                 gb: NM_002122.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4504406 
               
               
                   
                   
                   
                   
                 /GEN = HLA-DQA1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 126 
               
               
                   
                   
                   
                   
                 /TID = Hs.198253.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 37 
               
               
                   
                   
                   
                   
                 /UG = Hs.198253 /LL = 3117 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  major 
               
               
                   
                   
                   
                   
                 histocompatibility complex, 
               
               
                   
                   
                   
                   
                 class II, DQ alpha 1 (HLA- 
               
               
                   
                   
                   
                   
                 DQA1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = major 
               
               
                   
                   
                   
                   
                 histocompatibility complex, 
               
               
                   
                   
                   
                   
                 class II, DQalpha 1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002122.1 
               
               
                   
                   
                   
                   
                 gb: M33906.1 gb: M16995.1 
               
               
                   
                   
                   
                   
                 gb: M26041.1 gb: M17847.1 
               
               
                   
                   
                   
                   
                 gb: M17846.1 
               
               
                 204778_x_at 
                 −2.24 
                 HOXB7 
                 Underexpressed 
                 gb: AW102783 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6073396 
               
               
                   
                   
                   
                   
                 /DB_XREF = xd38a03.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2596012 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 52 
               
               
                   
                   
                   
                   
                 /TID = Hs.819.0 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 8 /UG = Hs.819 
               
               
                   
                   
                   
                   
                 /LL = 3217 
               
               
                   
                   
                   
                   
                 /UG_GENE = HOXB7 
               
               
                   
                   
                   
                   
                 /UG_TITLE = homeo box B7 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_004502.1 
               
               
                   
                   
                   
                   
                 gb: M16937.1 
               
               
                 241036_at 
                 −3.01 
                 HPS3 
                 Underexpressed 
                 gb: AA215451 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 1815195 
               
               
                   
                   
                   
                   
                 /DB_XREF = zr97d04.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 683623 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.189025.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 
               
               
                   
                   
                   
                   
                 /UG = Hs.189025 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206638_at 
                 −2.51 
                 HTR2B 
                 Underexpressed 
                 gb: NM_000867.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4504538 
               
               
                   
                   
                   
                   
                 /GEN = HTR2B 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 13 
               
               
                   
                   
                   
                   
                 /TID = Hs.2507.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.2507 /LL = 3357 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  5- 
               
               
                   
                   
                   
                   
                 hydroxytryptamine (serotonin) 
               
               
                   
                   
                   
                   
                 receptor 2B (HTR2B), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = 5- 
               
               
                   
                   
                   
                   
                 hydroxytryptamine (serotonin) 
               
               
                   
                   
                   
                   
                 receptor 2B 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000867.1 
               
               
                 1566502_at 
                 −2.66 
                 HYDIN 
                 Underexpressed 
                 gb: AL157445.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7018447 
               
               
                   
                   
                   
                   
                 /TID = Hs2.375670.1 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.375670 
               
               
                   
                   
                   
                   
                 /UG TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 mRNA; cDNA 
               
               
                   
                   
                   
                   
                 DKFZp434B049 (from clone 
               
               
                   
                   
                   
                   
                 DKFZp434B049) 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                 cDNA DKFZp434B049 (from 
               
               
                   
                   
                   
                   
                 clone DKFZp434B049). 
               
               
                 205302_at 
                 −53.23 
                 IGFBP1 
                 Underexpressed 
                 gb: NM_000596.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4504614 
               
               
                   
                   
                   
                   
                 /GEN = IGFBP1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 268 
               
               
                   
                   
                   
                   
                 /TID = Hs.102122.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 117 
               
               
                   
                   
                   
                   
                 /UG = Hs.102122 /LL = 3484 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  insulin- 
               
               
                   
                   
                   
                   
                 like growth factor binding 
               
               
                   
                   
                   
                   
                 protein 1 (IGFBP1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = insulin-like growth 
               
               
                   
                   
                   
                   
                 factor binding protein 1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000596.1 
               
               
                   
                   
                   
                   
                 gb: M31145.1 gb: M20841.1 
               
               
                 221651_x_at 
                 −2.38 
                 IGKC 
                 Underexpressed 
                 gb: BC005332.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 13529115 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.156110.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.156110 
               
               
                   
                   
                   
                   
                 /LL = 3514 /UG_GENE = IGKC 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens , Similar 
               
               
                   
                   
                   
                   
                 to immunoglobulin kappa 
               
               
                   
                   
                   
                   
                 constant, clone MGC: 12418, 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = Similar to 
               
               
                   
                   
                   
                   
                 immunoglobulin kappa 
               
               
                   
                   
                   
                   
                 constant /FL = gb: AF113887.1 
               
               
                   
                   
                   
                   
                 gb: BC005332.1 
               
               
                 205038_at 
                 2.06 
                 IKZF1 
                 Overexpressed 
                 gb: BG540504 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 13532737 
               
               
                   
                   
                   
                   
                 /DB_XREF = 602569230F1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 4693783 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 54 
               
               
                   
                   
                   
                   
                 /TID = Hs.54452.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.54452 /LL = 10320 
               
               
                   
                   
                   
                   
                 /UG_GENE = ZNFN1A1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = zinc finger 
               
               
                   
                   
                   
                   
                 protein, subfamily 1A, 1 
               
               
                   
                   
                   
                   
                 (Ikaros) /FL = gb: U40462.1 
               
               
                   
                   
                   
                   
                 gb: NM_006060.1 
               
               
                 205992_s_at 
                 −2.76 
                 IL15 
                 Underexpressed 
                 gb: NM_000585.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10835152 
               
               
                   
                   
                   
                   
                 /GEN = IL15 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 33 /TID = Hs.168132.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.168132 /LL = 3600 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 interleukin 15 (IL15), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = interleukin 15 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000585.1 
               
               
                   
                   
                   
                   
                 gb: U14407.1 
               
               
                 205067_at 
                 −2.14 
                 IL1B 
                 Underexpressed 
                 gb: NM_000576.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10835144 
               
               
                   
                   
                   
                   
                 /GEN = IL1B /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 97 /TID = Hs.126256.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 15 
               
               
                   
                   
                   
                   
                 /UG = Hs.126256 /LL = 3553 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 interleukin 1, beta (IL1B), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = interleukin 1, 
               
               
                   
                   
                   
                   
                 beta /FL = gb: M15330.1 
               
               
                   
                   
                   
                   
                 gb: M54933.1 gb: K02770.1 
               
               
                   
                   
                   
                   
                 gb: NM_000576.1 
               
               
                 207526_s_at 
                 −2.93 
                 IL1RL1 
                 Underexpressed 
                 gb: NM_003856.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4507244 
               
               
                   
                   
                   
                   
                 /GEN = IL1RL1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.66.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.66 
               
               
                   
                   
                   
                   
                 /LL = 9173 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  interleukin 1 receptor- 
               
               
                   
                   
                   
                   
                 like 1 (IL1RL1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = interleukin 1 
               
               
                   
                   
                   
                   
                 receptor-like 1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_003856.1 
               
               
                 205291_at 
                 −2.77 
                 IL2RB 
                 Underexpressed 
                 gb: NM_000878.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4504664 
               
               
                   
                   
                   
                   
                 /GEN = IL2RB 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 45 
               
               
                   
                   
                   
                   
                 /TID = Hs.75596.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 26 
               
               
                   
                   
                   
                   
                 /UG = Hs.75596 /LL = 3560 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 interleukin 2 receptor, beta 
               
               
                   
                   
                   
                   
                 (IL2RB), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = interleukin 2 
               
               
                   
                   
                   
                   
                 receptor, beta 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000878.1 
               
               
                   
                   
                   
                   
                 gb: M26062.1 
               
               
                 204698_at 
                 2.74 
                 ISG20 
                 Overexpressed 
                 gb: NM_002201.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6857799 
               
               
                   
                   
                   
                   
                 /GEN = ISG20 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 51 
               
               
                   
                   
                   
                   
                 /TID = Hs.183487.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 21 
               
               
                   
                   
                   
                   
                 /UG = Hs.183487 /LL = 3669 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 interferon stimulated gene 
               
               
                   
                   
                   
                   
                 (20 kD) (ISG20), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = interferon stimulated 
               
               
                   
                   
                   
                   
                 gene (20 kD) 
               
               
                   
                   
                   
                   
                 /FL = gb: U88964.1 
               
               
                   
                   
                   
                   
                 gb: NM_002201.2 
               
               
                 208084_at 
                 −2.13 
                 ITGB6 
                 Underexpressed 
                 gb: NM_000888.3 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 9966771 
               
               
                   
                   
                   
                   
                 /GEN = ITGB6 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.123125.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.123125 
               
               
                   
                   
                   
                   
                 /LL = 3694 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  integrin, beta 6 
               
               
                   
                   
                   
                   
                 (ITGB6), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = integrin, beta 6 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000888.3 
               
               
                   
                   
                   
                   
                 gb: M35198.3 
               
               
                 210036_s_at 
                 −2.06 
                 KCNH2 
                 Underexpressed 
                 gb: AB044806.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11933151 
               
               
                   
                   
                   
                   
                 /GEN = HERG 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 34 
               
               
                   
                   
                   
                   
                 /TID = Hs.188021.1 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 24 
               
               
                   
                   
                   
                   
                 /UG = Hs.188021 /LL = 3757 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  HERG 
               
               
                   
                   
                   
                   
                 mRNA for HERG-USO, 
               
               
                   
                   
                   
                   
                 alternatively spliced, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = HERG-USO 
               
               
                   
                   
                   
                   
                 /FL = gb: AB044806.1 
               
               
                 231774_at 
                 −2.42 
                 KCNIP3 
                 Underexpressed 
                 gb: R17174 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 770784 
               
               
                   
                   
                   
                   
                 /DB_XREF = yg11a08.r1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 31713 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 14 
               
               
                   
                   
                   
                   
                 /TID = Hs.13228.1 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.13228 /LL = 30818 
               
               
                   
                   
                   
                   
                 /UG_GENE = CSEN 
               
               
                   
                   
                   
                   
                 /UG_TITLE = Calsenilin, 
               
               
                   
                   
                   
                   
                 presenilin-binding protein, EF 
               
               
                   
                   
                   
                   
                 hand transcription factor 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_013434.1 
               
               
                   
                   
                   
                   
                 gb: AF199599.1 
               
               
                   
                   
                   
                   
                 gb: AF120102.1 
               
               
                 237249_at 
                 −2.09 
                 KCNQ1 
                 Underexpressed 
                 gb: AI970466 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5767292 
               
               
                   
                   
                   
                   
                 /DB_XREF = wq93b06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2479571 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 8 
               
               
                   
                   
                   
                   
                 /TID = Hs.95162.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 5 
               
               
                   
                   
                   
                   
                 /UG = Hs.95162 /LL = 10984 
               
               
                   
                   
                   
                   
                 /UG_GENE = KCNQ1OT1 
               
               
                   
                   
                   
                   
                 /UG_TITLE = KCNQ1 
               
               
                   
                   
                   
                   
                 overlapping transcript 1 
               
               
                 242517_at 
                 −2.9 
                 KISS1R 
                 Underexpressed 
                 gb: AI819198 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5438277 
               
               
                   
                   
                   
                   
                 /DB_XREF = wj32f02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2404539 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.208229.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.208229 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206785_s_at 
                 −2.86 
                 KLRC2 
                 Underexpressed 
                 gb: NM_002260.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7108353 
               
               
                   
                   
                   
                   
                 /GEN = KLRC2 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 12 
               
               
                   
                   
                   
                   
                 /TID = Hs.177605.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /UG = Hs.177605 
               
               
                   
                   
                   
                   
                 /LL = 3822 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  killer cell lectin-like 
               
               
                   
                   
                   
                   
                 receptor subfamily C, member 
               
               
                   
                   
                   
                   
                 2 (KLRC2), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = killer cell lectin-like 
               
               
                   
                   
                   
                   
                 receptor subfamily C, member 
               
               
                   
                   
                   
                   
                 2 /FL = gb: NM_002260.2 
               
               
                   
                   
                   
                   
                 gb: AF260134.1 
               
               
                 209351_at 
                 −2.85 
                 KRT14 
                 Underexpressed 
                 gb: BC002690.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 12803708 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 212 
               
               
                   
                   
                   
                   
                 /TID = Hs.117729.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 53 
               
               
                   
                   
                   
                   
                 /UG = Hs.117729 /LL = 3861 
               
               
                   
                   
                   
                   
                 /UG_GENE = KRT14 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens , keratin 
               
               
                   
                   
                   
                   
                 14 (epidermolysis bullosa 
               
               
                   
                   
                   
                   
                 simplex, Dowling-Meara, 
               
               
                   
                   
                   
                   
                 Koebner), clone MGC: 3944, 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = keratin 14 
               
               
                   
                   
                   
                   
                 (epidermolysis bullosa 
               
               
                   
                   
                   
                   
                 simplex, Dowling-Meara, 
               
               
                   
                   
                   
                   
                 Koebner) 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000526.1 
               
               
                   
                   
                   
                   
                 gb: BC002690.1 
               
               
                 235871_at 
                 −2.91 
                 LIPH 
                 Underexpressed 
                 gb: AA088857 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 1634387 
               
               
                   
                   
                   
                   
                 /DB_XREF = z190f03.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 511901 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 14 
               
               
                   
                   
                   
                   
                 /TID = Hs.68864.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 2 
               
               
                   
                   
                   
                   
                 /UG = Hs.68864 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs, Weakly 
               
               
                   
                   
                   
                   
                 similar to phosphatidylserine- 
               
               
                   
                   
                   
                   
                 specific phospholipase A1 
               
               
                   
                   
                   
                   
                 deltaC ( H. sapiens ) 
               
               
                 219759_at 
                 −6.02 
                 LRAP 
                 Underexpressed 
                 gb: NM_022350.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11641260 
               
               
                   
                   
                   
                   
                 /GEN = LOC64167 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.280380.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.280380 
               
               
                   
                   
                   
                   
                 /LL = 64167 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  aminopeptidase 
               
               
                   
                   
                   
                   
                 (LOC64167), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = aminopeptidase 
               
               
                   
                   
                   
                   
                 /FL = gb: AF191545.1 
               
               
                   
                   
                   
                   
                 gb: NM_022350.1 
               
               
                 211018_at 
                 −2.14 
                 LSS 
                 Underexpressed 
                 gb: D63807.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 1019365 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 3 
               
               
                   
                   
                   
                   
                 /TID = Hs.93199.1 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.93199 
               
               
                   
                   
                   
                   
                 /LL = 4047 /UG_GENE = LSS 
               
               
                   
                   
                   
                   
                 /DEF = Human mRNA for 
               
               
                   
                   
                   
                   
                 lanosterol synthase, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = lanosterol 
               
               
                   
                   
                   
                   
                 synthase /FL = gb: D63807.1 
               
               
                 232819_s_at 
                 −2.81 
                 LTBR 
                 Underexpressed 
                 gb: L04489.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 340022 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.117847.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.117847 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 (clone NCD18) tumor 
               
               
                   
                   
                   
                   
                 necrosis factor receptor 
               
               
                   
                   
                   
                   
                 related protein mRNA, 
               
               
                   
                   
                   
                   
                 complete exon and repeat 
               
               
                   
                   
                   
                   
                 region /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 (clone NCD18) tumor 
               
               
                   
                   
                   
                   
                 necrosis factor receptor 
               
               
                   
                   
                   
                   
                 related protein mRNA, 
               
               
                   
                   
                   
                   
                 complete exon and repeat 
               
               
                   
                   
                   
                   
                 region. 
               
               
                 204041_at 
                 −2.67 
                 MAOB 
                 Underexpressed 
                 gb: NM_000898.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505092 
               
               
                   
                   
                   
                   
                 /GEN = MAOB 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 79 
               
               
                   
                   
                   
                   
                 /TID = Hs.82163.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 39 
               
               
                   
                   
                   
                   
                 /UG = Hs.82163 /LL = 4129 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 monoamine oxidase B 
               
               
                   
                   
                   
                   
                 (MAOB), nuclear gene 
               
               
                   
                   
                   
                   
                 encoding mitochondrial 
               
               
                   
                   
                   
                   
                 protein, mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = monoamine oxidase 
               
               
                   
                   
                   
                   
                 B /FL = gb: NM_000898.1 
               
               
                   
                   
                   
                   
                 gb: M69177.1 
               
               
                 226023_at 
                 2.69 
                 MAP2K7 
                 Overexpressed 
                 gb: AI344194 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4081400 
               
               
                   
                   
                   
                   
                 /DB_XREF = tc02e10.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2062698 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 63 
               
               
                   
                   
                   
                   
                 /TID = Hs.296234.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 11 
               
               
                   
                   
                   
                   
                 /UG = Hs.296234 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 230848_s_at 
                 3.22 
                 MGA (includes 
                 Overexpressed 
                 gb: BF438227 
               
               
                   
                   
                 EG: 23269) 
                   
                 /DB_XREF = gi: 11450744 
               
               
                   
                   
                   
                   
                 /DB_XREF = 7q68g05.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3703497 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 10 
               
               
                   
                   
                   
                   
                 /TID = Hs.23763.1 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 8 
               
               
                   
                   
                   
                   
                 /UG = Hs.23763 /LL = 23269 
               
               
                   
                   
                   
                   
                 /UG_GENE = KIAA0518 
               
               
                   
                   
                   
                   
                 /UG_TITLE = Max-interacting 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 244523_at 
                 −2.12 
                 MMD 
                 Underexpressed 
                 gb: AW104453 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6075188 
               
               
                   
                   
                   
                   
                 /DB_XREF = xd78b02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2603691 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 7 
               
               
                   
                   
                   
                   
                 /TID = Hs.99734.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.99734 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 204580_at 
                 −6.06 
                 MMP12 
                 Underexpressed 
                 gb: NM_002426.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505206 
               
               
                   
                   
                   
                   
                 /GEN = MMP12 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 72 
               
               
                   
                   
                   
                   
                 /TID = Hs.1695.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.1695 /LL = 4321 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  matrix 
               
               
                   
                   
                   
                   
                 metalloproteinase 12 
               
               
                   
                   
                   
                   
                 (macrophage elastase) 
               
               
                   
                   
                   
                   
                 (MMP12), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = matrix 
               
               
                   
                   
                   
                   
                 metalloproteinase 12 
               
               
                   
                   
                   
                   
                 preproprotein 
               
               
                   
                   
                   
                   
                 /FL = gb: L23808.1 
               
               
                   
                   
                   
                   
                 gb: NM_002426.1 
               
               
                 208423_s_at 
                 2.44 
                 MSR1 
                 Overexpressed 
                 gb: NM_002445.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505258 
               
               
                   
                   
                   
                   
                 /GEN = MSR1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.49.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.49 
               
               
                   
                   
                   
                   
                 /LL = 4481 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  macrophage scavenger 
               
               
                   
                   
                   
                   
                 receptor 1 (MSR1), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = macrophage 
               
               
                   
                   
                   
                   
                 scavenger receptor 1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002445.1 
               
               
                 217109_at 
                 −2.93 
                 MUC4 
                 Underexpressed 
                 gb: AJ242547.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7406614 
               
               
                   
                   
                   
                   
                 /GEN = MUC4 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /CNT = 2 /TID = Hs.198267.2 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.198267 /LL = 4585 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  partial 
               
               
                   
                   
                   
                   
                 mRNA for sv7-MUC4 
               
               
                   
                   
                   
                   
                 apomucin. /PROD = sv7- 
               
               
                   
                   
                   
                   
                 MUC4 apomucin 
               
               
                 244149_at 
                 2.13 
                 MYL9 
                 Overexpressed 
                 gb: AA864758 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2959071 
               
               
                   
                   
                   
                   
                 /DB_XREF = oh37g07.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1460028 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 5 
               
               
                   
                   
                   
                   
                 /TID = Hs.134192.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.134192 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206022_at 
                 −3.79 
                 NDP 
                 Underexpressed 
                 gb: NM_000266.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4557788 
               
               
                   
                   
                   
                   
                 /GEN = NDP /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 28 /TID = Hs.2839.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.2839 /LL = 4693 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  Norrie 
               
               
                   
                   
                   
                   
                 disease (pseudoglioma) 
               
               
                   
                   
                   
                   
                 (NDP), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = Norrie disease protein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000266.1 
               
               
                 239450_at 
                 −2.18 
                 NDUFV2 
                 Underexpressed 
                 gb: AA846867 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2933007 
               
               
                   
                   
                   
                   
                 /DB_XREF = aj42d09.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1392977 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.116929.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 
               
               
                   
                   
                   
                   
                 /UG = Hs.116929 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 242267_x_at 
                 2.23 
                 NINJ2 
                 Overexpressed 
                 gb: T68304 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 679452 
               
               
                   
                   
                   
                   
                 /DB_XREF = yc41e01.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 83256 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 3 
               
               
                   
                   
                   
                   
                 /TID = Hs.182402.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.182402 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206578_at 
                 2.69 
                 NKX2-5 
                 Overexpressed 
                 gb: NM_004387.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4758089 
               
               
                   
                   
                   
                   
                 /GEN = CSX /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 15 /TID = Hs.54473.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.54473 /LL = 1482 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  cardiac- 
               
               
                   
                   
                   
                   
                 specific homeo box (CSX), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = cardiac- 
               
               
                   
                   
                   
                   
                 specific homeo box 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_004387.1 
               
               
                   
                   
                   
                   
                 gb: U34962.1 gb: AB021133.1 
               
               
                 243738_at 
                 2.22 
                 NMNAT3 
                 Overexpressed 
                 gb: AW172570 
               
               
                   
                   
                 (includes 
                   
                 /DB_XREF = gi: 6438518 
               
               
                   
                   
                 EG: 349565) 
                   
                 /DB_XREF = xj79g02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2663474 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 4 
               
               
                   
                   
                   
                   
                 /TID = Hs.130246.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.130246 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 231798_at 
                 −5.28 
                 NOG 
                 Underexpressed 
                 gb: AL575177 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 12936088 
               
               
                   
                   
                   
                   
                 /DB_XREF = AL575177 
               
               
                   
                   
                   
                   
                 /CLONE = CS0DI063YJ07 (3 
               
               
                   
                   
                   
                   
                 prime) /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 7 /TID = Hs.248201.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 1 
               
               
                   
                   
                   
                   
                 /UG = Hs.248201 /LL = 9241 
               
               
                   
                   
                   
                   
                 /UG_GENE = NOG 
               
               
                   
                   
                   
                   
                 /UG_TITLE = noggin 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_005450.1 
               
               
                 227816_at 
                 −3.56 
                 NTN1 
                 Underexpressed 
                 gb: BF591483 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11683807 
               
               
                   
                   
                   
                   
                 /DB_XREF = nab98c06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3275890 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 23 
               
               
                   
                   
                   
                   
                 /TID = Hs.96917.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 15 
               
               
                   
                   
                   
                   
                 /UG = Hs.96917 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 206563_s_at 
                 6.14 
                 OPRL1 
                 Overexpressed 
                 gb: AF348323.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 13022242 
               
               
                   
                   
                   
                   
                 /GEN = ORL1 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 15 
               
               
                   
                   
                   
                   
                 /TID = Hs.2859.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.2859 
               
               
                   
                   
                   
                   
                 /LL = 4987 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  nociceptin receptor 
               
               
                   
                   
                   
                   
                 (ORL1) mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = nociceptin receptor 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000913.1 
               
               
                   
                   
                   
                   
                 gb: U30185.1 gb: AF348323.1 
               
               
                 1553319_at 
                 −2.88 
                 OXGR1 
                 Underexpressed 
                 gb: AF370886.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 21728283 
               
               
                   
                   
                   
                   
                 /GEN = GPR99 
               
               
                   
                   
                   
                   
                 /TID = Hs2.352218.1 /CNT = 4 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /LL = 27199 
               
               
                   
                   
                   
                   
                 /UG = Hs.352218 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  G protein-coupled 
               
               
                   
                   
                   
                   
                 receptor GPR99 (GPR99) 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = G protein-coupled 
               
               
                   
                   
                   
                   
                 receptor GPR99 
               
               
                   
                   
                   
                   
                 /FL = gb: AF370886.1 
               
               
                   
                   
                   
                   
                 gb: NM_080818.1 
               
               
                 228703_at 
                 −2.21 
                 P4HA3 
                 Underexpressed 
                 gb: AW665086 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7457631 
               
               
                   
                   
                   
                   
                 /DB_XREF = hi99b06.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2980403 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 21 
               
               
                   
                   
                   
                   
                 /TID = Hs.179891.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 14 
               
               
                   
                   
                   
                   
                 /UG = Hs.179891 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs, Weakly 
               
               
                   
                   
                   
                   
                 similar to P4HA_HUMAN 
               
               
                   
                   
                   
                   
                 PROLYL 4- 
               
               
                   
                   
                   
                   
                 HYDROXYLASE ALPHA 
               
               
                   
                   
                   
                   
                 SUBUNIT PRECURSOR 
               
               
                   
                   
                   
                   
                 ( H. sapiens ) 
               
               
                 221286_s_at 
                 3.08 
                 PACAP 
                 Overexpressed 
                 gb: NM_016459.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7706002 
               
               
                   
                   
                   
                   
                 /GEN = LOC51237 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 10 
               
               
                   
                   
                   
                   
                 /TID = Hs.122492.1 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /UG = Hs.122492 
               
               
                   
                   
                   
                   
                 /LL = 51237 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  hypothetical protein 
               
               
                   
                   
                   
                   
                 (LOC51237), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = hypothetical protein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_016459.1 
               
               
                 206859_s_at 
                 −10.02 
                 PAEP 
                 Underexpressed 
                 gb: NM_002571.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505582 
               
               
                   
                   
                   
                   
                 /GEN = PAEP 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.82269.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 13 
               
               
                   
                   
                   
                   
                 /UG = Hs.82269 /LL = 5047 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 progestagen-associated 
               
               
                   
                   
                   
                   
                 endometrial protein (placental 
               
               
                   
                   
                   
                   
                 protein 14, pregnancy- 
               
               
                   
                   
                   
                   
                 associated endometrial alpha- 
               
               
                   
                   
                   
                   
                 2-globulin, alpha uterine 
               
               
                   
                   
                   
                   
                 protein) (PAEP), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = progestagen- 
               
               
                   
                   
                   
                   
                 associated endometrial 
               
               
                   
                   
                   
                   
                 protein(placental protein 14, 
               
               
                   
                   
                   
                   
                 pregnancy-associated 
               
               
                   
                   
                   
                   
                 endometrialalpha-2-globulin, 
               
               
                   
                   
                   
                   
                 alpha uterine protein) 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002571.1 
               
               
                   
                   
                   
                   
                 gb: J04129.1 
               
               
                 211818_s_at 
                 −3.42 
                 PDE4C 
                 Underexpressed 
                 gb: U88712.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 1857983 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 1 
               
               
                   
                   
                   
                   
                 /TID = Hs.189.2 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.189 
               
               
                   
                   
                   
                   
                 /LL = 5143 
               
               
                   
                   
                   
                   
                 /UG_GENE = PDE4C 
               
               
                   
                   
                   
                   
                 /DEF = Human 
               
               
                   
                   
                   
                   
                 phosphodiesterase 4C mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = phosphodiesterase 4C 
               
               
                   
                   
                   
                   
                 /FL = gb: U88712.1 
               
               
                 205593_s_at 
                 2 
                 PDE9A 
                 Overexpressed 
                 gb: NM_002606.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4505674 
               
               
                   
                   
                   
                   
                 /GEN = PDE9A 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 44 
               
               
                   
                   
                   
                   
                 /TID = Hs.18953.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.18953 /LL = 5152 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 phosphodiesterase 9A 
               
               
                   
                   
                   
                   
                 (PDE9A), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = phosphodiesterase 9A 
               
               
                   
                   
                   
                   
                 /FL = gb: AF048837.1 
               
               
                   
                   
                   
                   
                 gb: AF067223.1 
               
               
                   
                   
                   
                   
                 gb: NM_002606.1 
               
               
                 1568949_at 
                 −2.03 
                 PITPNC1 
                 Underexpressed 
                 gb: BM042439 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 16771706 
               
               
                   
                   
                   
                   
                 /DB_XREF = 603616266F1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 5556809 
               
               
                   
                   
                   
                   
                 /TID = Hs2.397451.1 /CNT = 33 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.397451 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 clone IMAGE: 3875257, 
               
               
                   
                   
                   
                   
                 mRNA 
               
               
                 219014_at 
                 −3.08 
                 PLAC8 
                 Underexpressed 
                 gb: NM_016619.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7706157 
               
               
                   
                   
                   
                   
                 /GEN = LOC51316 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 86 
               
               
                   
                   
                   
                   
                 /TID = Hs.107139.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.107139 
               
               
                   
                   
                   
                   
                 /LL = 51316 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  hypothetical protein 
               
               
                   
                   
                   
                   
                 (LOC51316), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = hypothetical protein 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_016619.1 
               
               
                   
                   
                   
                   
                 gb: AF208846.1 
               
               
                 228964_at 
                 −2.75 
                 PRDM1 
                 Underexpressed 
                 gb: AI692659 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4969999 
               
               
                   
                   
                   
                   
                 /DB_XREF = wd86d10.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2338483 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 22 
               
               
                   
                   
                   
                   
                 /TID = Hs.289088.2 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.289088 /LL = 3320 
               
               
                   
                   
                   
                   
                 /UG_GENE = HSPCA 
               
               
                   
                   
                   
                   
                 /UG_TITLE = heat shock 90 kD 
               
               
                   
                   
                   
                   
                 protein 1, alpha 
               
               
                 211743_s_at 
                 −4.67 
                 PRG2 (includes 
                 Underexpressed 
                 gb: BC005929.1 
               
               
                   
                   
                 EG: 5553) 
                   
                 /DB_XREF = gi: 13543541 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 1 
               
               
                   
                   
                   
                   
                 /TID = HsAffx.900770.968 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens , 
               
               
                   
                   
                   
                   
                 proteoglycan 2, bone marrow 
               
               
                   
                   
                   
                   
                 (natural killer cell activator, 
               
               
                   
                   
                   
                   
                 eosinophil granule major basic 
               
               
                   
                   
                   
                   
                 protein), clone MGC: 14537, 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = proteoglycan 2, bone 
               
               
                   
                   
                   
                   
                 marrow (natural killer 
               
               
                   
                   
                   
                   
                 cellactivator, eosinophil 
               
               
                   
                   
                   
                   
                 granule major basic protein) 
               
               
                   
                   
                   
                   
                 /FL = gb: BC005929.1 
               
               
                 205445_at 
                 −7.86 
                 PRL 
                 Underexpressed 
                 gb: NM_000948.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4506104 
               
               
                   
                   
                   
                   
                 /GEN = PRL /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 352 /TID = Hs.1905.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 19 
               
               
                   
                   
                   
                   
                 /UG = Hs.1905 /LL = 5617 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  prolactin 
               
               
                   
                   
                   
                   
                 (PRL), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = prolactin 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_000948.1 
               
               
                 237234_at 
                 −2.83 
                 PSCD2 
                 Underexpressed 
                 gb: AA700869 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 2704034 
               
               
                   
                   
                   
                   
                 /DB_XREF = zj36c04.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 452358 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 6 
               
               
                   
                   
                   
                   
                 /TID = Hs.119761.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 6 
               
               
                   
                   
                   
                   
                 /UG = Hs.119761 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 204945_at 
                 2.47 
                 PTPRN 
                 Overexpressed 
                 gb: NM_002846.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4506320 
               
               
                   
                   
                   
                   
                 /GEN = PTPRN 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 76 
               
               
                   
                   
                   
                   
                 /TID = Hs.89655.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 20 
               
               
                   
                   
                   
                   
                 /UG = Hs.89655 /LL = 5798 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  protein 
               
               
                   
                   
                   
                   
                 tyrosine phosphatase, receptor 
               
               
                   
                   
                   
                   
                 type, N (PTPRN), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = protein tyrosine 
               
               
                   
                   
                   
                   
                 phosphatase, receptor type, N 
               
               
                   
                   
                   
                   
                 /FL = gb: L18983.1 
               
               
                   
                   
                   
                   
                 gb: NM_002846.1 
               
               
                 210823_s_at 
                 −2.29 
                 PTPRS(includes 
                 Underexpressed 
                 gb: U40317.1 
               
               
                   
                   
                 EG: 
                   
                 /DB_XREF = gi: 1407624 
               
               
                   
                   
                   
                   
                 /GEN = PTPsigma 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.159534.1 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.159534 
               
               
                   
                   
                   
                   
                 /LL = 5802 /DEF = Human 
               
               
                   
                   
                   
                   
                 protein tyrosine phosphatase 
               
               
                   
                   
                   
                   
                 PTPsigma (PTPsigma) 
               
               
                   
                   
                   
                   
                 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = PTPsigma 
               
               
                   
                   
                   
                   
                 /FL = gb: U40317.1 
               
               
                 235059_at 
                 −4.54 
                 RAB12 
                 Underexpressed 
                 gb: BF574430 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11648142 
               
               
                   
                   
                   
                   
                 /DB_XREF = 602131648F1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 4271098 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 24 
               
               
                   
                   
                   
                   
                 /TID = Hs.29739.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.29739 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs, Weakly 
               
               
                   
                   
                   
                   
                 similar to C34323 GTP- 
               
               
                   
                   
                   
                   
                 binding protein Rab3A 
               
               
                   
                   
                   
                   
                 ( H. sapiens ) 
               
               
                 211904_x_at 
                 2.01 
                 RAD52 
                 Overexpressed 
                 gb: AF125950.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4581009 
               
               
                   
                   
                   
                   
                 /GEN = RAD52 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.89571.3 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.89571 
               
               
                   
                   
                   
                   
                 /LL = 5893 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  DNA repair protein 
               
               
                   
                   
                   
                   
                 RAD52 beta isoform 
               
               
                   
                   
                   
                   
                 (RAD52) mRNA, 
               
               
                   
                   
                   
                   
                 alternatively spliced, complete 
               
               
                   
                   
                   
                   
                 cds. /PROD = DNA repair 
               
               
                   
                   
                   
                   
                 protein RAD52 beta isoform 
               
               
                   
                   
                   
                   
                 /FL = gb: AF125950.1 
               
               
                 219140_s_at 
                 −3.94 
                 RBP4 
                 Underexpressed 
                 gb: NM_006744.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 8400727 
               
               
                   
                   
                   
                   
                 /GEN = RBP4 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 153 /TID = Hs.76461.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 50 
               
               
                   
                   
                   
                   
                 /UG = Hs.76461 /LL = 5950 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  retinol- 
               
               
                   
                   
                   
                   
                 binding protein 4, interstitial 
               
               
                   
                   
                   
                   
                 (RBP4), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = retinol-binding 
               
               
                   
                   
                   
                   
                 protein 4, interstitialprecursor 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006744.2 
               
               
                   
                   
                   
                   
                 gb: AF119868.1 
               
               
                 204535_s_at 
                 2.34 
                 REST 
                 Overexpressed 
                 gb: AI978576 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5803606 
               
               
                   
                   
                   
                   
                 /DB_XREF = wq72c11.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2476820 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 60 
               
               
                   
                   
                   
                   
                 /TID = Hs.227630.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 9 
               
               
                   
                   
                   
                   
                 /UG = Hs.227630 /LL = 5978 
               
               
                   
                   
                   
                   
                 /UG_GENE = REST 
               
               
                   
                   
                   
                   
                 /UG_TITLE = RE1-silencing 
               
               
                   
                   
                   
                   
                 transcription factor 
               
               
                   
                   
                   
                   
                 /FL = gb: U22680.1 
               
               
                   
                   
                   
                   
                 gb: U22314.1 
               
               
                   
                   
                   
                   
                 gb: NM_005612.1 
               
               
                 210586_x_at 
                 −6.11 
                 RHD 
                 Underexpressed 
                 gb: AF312679.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 11878260 
               
               
                   
                   
                   
                   
                 /GEN = RHD /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 20 /TID = Hs.278994.0 
               
               
                   
                   
                   
                   
                 /TIER = FL /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.278994 /LL = 6006 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  rhesus D 
               
               
                   
                   
                   
                   
                 category VI type IV protein 
               
               
                   
                   
                   
                   
                 (RHD) mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = rhesus D category VI 
               
               
                   
                   
                   
                   
                 type IV protein 
               
               
                   
                   
                   
                   
                 /FL = gb: AF056965.1 
               
               
                   
                   
                   
                   
                 gb: AB018644.1 
               
               
                   
                   
                   
                   
                 gb: AB018645.1 
               
               
                   
                   
                   
                   
                 gb: NM_020485.1 
               
               
                   
                   
                   
                   
                 gb: M34015.1 gb: AB049754.1 
               
               
                   
                   
                   
                   
                 gb: AB049753.1 
               
               
                   
                   
                   
                   
                 gb: AF312679.1 
               
               
                   
                   
                   
                   
                 gb: AB030388.1 
               
               
                 231040_at 
                 −13.24 
                 RORB 
                 Underexpressed 
                 gb: AW512988 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7151066 
               
               
                   
                   
                   
                   
                 /DB_XREF = xt76b02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2792331 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 9 
               
               
                   
                   
                   
                   
                 /TID = Hs.184780.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 9 
               
               
                   
                   
                   
                   
                 /UG = Hs.184780 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 205863_at 
                 2.7 
                 S100A12 
                 Overexpressed 
                 gb: NM_005621.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5032058 
               
               
                   
                   
                   
                   
                 /GEN = S100A12 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 34 
               
               
                   
                   
                   
                   
                 /TID = Hs.19413.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 12 
               
               
                   
                   
                   
                   
                 /UG = Hs.19413 /LL = 6283 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  S100 
               
               
                   
                   
                   
                   
                 calcium-binding protein A12 
               
               
                   
                   
                   
                   
                 (calgranulin C) (S100A12), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = S100 
               
               
                   
                   
                   
                   
                 calcium-binding protein A12 
               
               
                   
                   
                   
                   
                 /FL = gb: D83664.1 
               
               
                   
                   
                   
                   
                 gb: D49549.1 
               
               
                   
                   
                   
                   
                 gb: NM_005621.1 
               
               
                 202917_s_at 
                 3.2 
                 S100A8 
                 Overexpressed 
                 gb: NM_002964.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 9845519 
               
               
                   
                   
                   
                   
                 /GEN = S100A8 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 257 
               
               
                   
                   
                   
                   
                 /TID = Hs.100000.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 93 
               
               
                   
                   
                   
                   
                 /UG = Hs.100000 /LL = 6279 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  S100 
               
               
                   
                   
                   
                   
                 calcium-binding protein A8 
               
               
                   
                   
                   
                   
                 (calgranulin A) (S100A8), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = S100 
               
               
                   
                   
                   
                   
                 calcium-binding protein A8 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_002964.2 
               
               
                 230077_at 
                 −2.05 
                 SDHAL1 
                 Underexpressed 
                 gb: W90764 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 1406730 
               
               
                   
                   
                   
                   
                 /DB_XREF = zh79h02.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 418323 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 14 
               
               
                   
                   
                   
                   
                 /TID = Hs.469.1 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 8 /UG = Hs.469 
               
               
                   
                   
                   
                   
                 /LL = 6389 
               
               
                   
                   
                   
                   
                 /UG_GENE = SDHA 
               
               
                   
                   
                   
                   
                 /UG_TITLE = succinate 
               
               
                   
                   
                   
                   
                 dehydrogenase complex, 
               
               
                   
                   
                   
                   
                 subunit A, flavoprotein (Fp) 
               
               
                 203789_s_at 
                 −2.15 
                 SEMA3C 
                 Underexpressed 
                 gb: NM_006379.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5454047 
               
               
                   
                   
                   
                   
                 /GEN = SEMA3C 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 92 
               
               
                   
                   
                   
                   
                 /TID = Hs.171921.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.171921 /LL = 10512 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  sema 
               
               
                   
                   
                   
                   
                 domain, immunoglobulin 
               
               
                   
                   
                   
                   
                 domain (Ig), short basic 
               
               
                   
                   
                   
                   
                 domain, secreted, 
               
               
                   
                   
                   
                   
                 (semaphorin) 3C (SEMA3C), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = sema 
               
               
                   
                   
                   
                   
                 domain, immunoglobulin 
               
               
                   
                   
                   
                   
                 domain (Ig), shortbasic 
               
               
                   
                   
                   
                   
                 domain, secreted, 
               
               
                   
                   
                   
                   
                 (semaphorin) 3C 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006379.1 
               
               
                   
                   
                   
                   
                 gb: AB000220.1 
               
               
                 202376_at 
                 −12.84 
                 SERPINA3 
                 Underexpressed 
                 gb: NM_001085.2 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 9665246 
               
               
                   
                   
                   
                   
                 /GEN = SERPINA3 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 230 
               
               
                   
                   
                   
                   
                 /TID = Hs.234726.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 128 
               
               
                   
                   
                   
                   
                 /UG = Hs.234726 /LL = 12 
               
               
                   
                   
                   
                   
                 /DEF =  Home sapiens  serine 
               
               
                   
                   
                   
                   
                 (or cysteine) proteinase 
               
               
                   
                   
                   
                   
                 inhibitor, clade A (alpha-1 
               
               
                   
                   
                   
                   
                 antiproteinase, antitrypsin), 
               
               
                   
                   
                   
                   
                 member 3 (SERPINA3), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = alpha-1- 
               
               
                   
                   
                   
                   
                 antichymotrypsin, precursor 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_001085.2 
               
               
                   
                   
                   
                   
                 gb: BC003559.1 gb: K01500.1 
               
               
                 207873_x_at 
                 3.13 
                 SEZ6L 
                 Overexpressed 
                 gb: NM_021115.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10863914 
               
               
                   
                   
                   
                   
                 /GEN = SEZ6L 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.194766.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.194766 
               
               
                   
                   
                   
                   
                 /LL = 23544 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  seizure related gene 6 
               
               
                   
                   
                   
                   
                 (mouse)-like (SEZ6L), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = seizure 
               
               
                   
                   
                   
                   
                 related gene 6 (mouse)-like 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_021115.1 
               
               
                 238273_at 
                 −2.45 
                 SLC13A4 
                 Underexpressed 
                 gb: AW007221 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5855999 
               
               
                   
                   
                   
                   
                 /DB_XREF = ws50f07.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2500645 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 5 
               
               
                   
                   
                   
                   
                 /TID = Hs.200022.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 5 
               
               
                   
                   
                   
                   
                 /UG = Hs.200022 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 228844_at 
                 2.78 
                 SLC13A5 
                 Overexpressed 
                 gb: AI797218 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5362690 
               
               
                   
                   
                   
                   
                 /DB_XREF = we86a02.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2347946 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 40 
               
               
                   
                   
                   
                   
                 /TID = Hs.11860.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 17 
               
               
                   
                   
                   
                   
                 /UG = Hs.11860 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 202498_s_at 
                 −2.33 
                 SLC2A3 
                 Underexpressed 
                 gb: BE550486 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 9792178 
               
               
                   
                   
                   
                   
                 /DB_XREF = 7a27c01.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 3219936 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 182 
               
               
                   
                   
                   
                   
                 /TID = Hs.7594.0 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 8 /UG = Hs.7594 
               
               
                   
                   
                   
                   
                 /LL = 6515 
               
               
                   
                   
                   
                   
                 /UG_GENE = SLC2A3 
               
               
                   
                   
                   
                   
                 /UG_TITLE = solute carrier 
               
               
                   
                   
                   
                   
                 family 2 (facilitated glucose 
               
               
                   
                   
                   
                   
                 transporter), member 3 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006931.1 
               
               
                   
                   
                   
                   
                 gb: M20681.1 
               
               
                 219911_s_at 
                 −3.23 
                 SLCO4A1 
                 Underexpressed 
                 gb: NM_016354.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7706516 
               
               
                   
                   
                   
                   
                 /GEN = SLC21A12 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 19 
               
               
                   
                   
                   
                   
                 /TID = Hs.235782.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 1 /UG = Hs.235782 
               
               
                   
                   
                   
                   
                 /LL = 28231 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  solute carrier family 
               
               
                   
                   
                   
                   
                 21 (organic anion transporter), 
               
               
                   
                   
                   
                   
                 member 12 (SLC21A12), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = organic 
               
               
                   
                   
                   
                   
                 anion transporter OATP-E 
               
               
                   
                   
                   
                   
                 /FL = gb: AB031051.1 
               
               
                   
                   
                   
                   
                 gb: NM_016354.1 
               
               
                   
                   
                   
                   
                 gb: AF205072.1 
               
               
                   
                   
                   
                   
                 gb: AF187817.1 
               
               
                 214404_x_at 
                 2.13 
                 SPDEF 
                 Overexpressed 
                 gb: AI435670 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4304809 
               
               
                   
                   
                   
                   
                 /DB_XREF = th53b09.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2121977 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 18 
               
               
                   
                   
                   
                   
                 /TID = Hs.79414.2 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.79414 /LL = 25803 
               
               
                   
                   
                   
                   
                 /UG_GENE = PDEF 
               
               
                   
                   
                   
                   
                 /UG_TITLE = prostate 
               
               
                   
                   
                   
                   
                 epithelium-specific Ets 
               
               
                   
                   
                   
                   
                 transcription factor 
               
               
                 216965_x_at 
                 −2.56 
                 SPG20 
                 Underexpressed 
                 gb: AL139377 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 10185469 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.118087.2 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.118087 /LL = 23111 
               
               
                   
                   
                   
                   
                 /UG_GENE = KIAA0610 
               
               
                   
                   
                   
                   
                 /UG_TITLE = KIAA0610 
               
               
                   
                   
                   
                   
                 protein /DEF = Human DNA 
               
               
                   
                   
                   
                   
                 sequence from clone RP11- 
               
               
                   
                   
                   
                   
                 251J8 on chromosome 13 
               
               
                   
                   
                   
                   
                 Contains ESTs, STSs, GSSs 
               
               
                   
                   
                   
                   
                 and a CpG island. Contains 
               
               
                   
                   
                   
                   
                 two novel genes with two 
               
               
                   
                   
                   
                   
                 isoforms each and the 
               
               
                   
                   
                   
                   
                 KIAA0610 gene with two 
               
               
                   
                   
                   
                   
                 isoforms 
               
               
                 202363_at 
                 −5.51 
                 SPOCK1 
                 Underexpressed 
                 gb: AF231124.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 7248844 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 190 
               
               
                   
                   
                   
                   
                 /TID = Hs.93029.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 68 
               
               
                   
                   
                   
                   
                 /UG = Hs.93029 /LL = 6695 
               
               
                   
                   
                   
                   
                 /UG_GENE = SPOCK 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  testican- 
               
               
                   
                   
                   
                   
                 1 mRNA, complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = testican-1 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_04598.1 
               
               
                   
                   
                   
                   
                 gb: AF231124.1 
               
               
                 208539_x_at 
                 2.25 
                 SPRR2B 
                 Overexpressed 
                 gb: NM_006945.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5902119 
               
               
                   
                   
                   
                   
                 /GEN = SPRR2B 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.231622.0 /TIER = FL 
               
               
                   
                   
                   
                   
                 /STK = 0 /UG = Hs.231622 
               
               
                   
                   
                   
                   
                 /LL = 6701 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  small proline-rich 
               
               
                   
                   
                   
                   
                 protein 2B (SPRR2B), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = small 
               
               
                   
                   
                   
                   
                 proline-rich protein 2B 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_006945.1 
               
               
                 202400_s_at 
                 2.35 
                 SRF 
                 Overexpressed 
                 gb: AI188786 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 3739995 
               
               
                   
                   
                   
                   
                 /DB_XREF = qd16g09.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 1723936 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 153 
               
               
                   
                   
                   
                   
                 /TID = Hs.155321.0 
               
               
                   
                   
                   
                   
                 /TIER = Stack /STK = 18 
               
               
                   
                   
                   
                   
                 /UG = Hs.155321 /LL = 6722 
               
               
                   
                   
                   
                   
                 /UG_GENE = SRF 
               
               
                   
                   
                   
                   
                 /UG_TITLE = serum response 
               
               
                   
                   
                   
                   
                 factor (c-fos serum response 
               
               
                   
                   
                   
                   
                 element-binding transcription 
               
               
                   
                   
                   
                   
                 factor) /FL = gb: J03161.1 
               
               
                   
                   
                   
                   
                 gb: NM_003131.1 
               
               
                 235591_at 
                 −2.84 
                 SSTR1 
                 Underexpressed 
                 gb: R62424 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 834303 
               
               
                   
                   
                   
                   
                 /DB_XREF = yg52c10.s1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 36221 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 11 
               
               
                   
                   
                   
                   
                 /TID = Hs.126059.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.126059 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 223285_s_at 
                 −2.29 
                 ST6GALNAC4 
                 Underexpressed 
                 gb: AW044319 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5904848 
               
               
                   
                   
                   
                   
                 /DB_XREF = wv67g10.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2534658 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 126 
               
               
                   
                   
                   
                   
                 /TID = Hs.3972.1 /TIER = Stack 
               
               
                   
                   
                   
                   
                 /STK = 8 /UG = Hs.3972 
               
               
                   
                   
                   
                   
                 /LL = 27090 
               
               
                   
                   
                   
                   
                 /UG_GENE = ST6GALNACIV 
               
               
                   
                   
                   
                   
                 /UG_TITLE = NeuAc-alpha- 
               
               
                   
                   
                   
                   
                 2,3-Gal-beta-1,3-GalNAc- 
               
               
                   
                   
                   
                   
                 alpha-2,6-sialyltransferase 
               
               
                   
                   
                   
                   
                 alpha2,6-sialyltransferase 
               
               
                   
                   
                   
                   
                 /FL = gb: AB035172.1 
               
               
                 1570420_at 
                 2.25 
                 STXBP2 
                 Overexpressed 
                 gb: AF318317.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 18027725 
               
               
                   
                   
                   
                   
                 /GEN = pp10122 
               
               
                   
                   
                   
                   
                 /TID = Hs2.398002.1 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.398002 /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  pp10122 mRNA, 
               
               
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                   
                   
                 /PROD = unknown 
               
               
                 204776_at 
                 −3.94 
                 THBS4 
                 Underexpressed 
                 gb: NM_003248.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4507488 
               
               
                   
                   
                   
                   
                 /GEN = THBS4 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 69 
               
               
                   
                   
                   
                   
                 /TID = Hs.75774.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 37 
               
               
                   
                   
                   
                   
                 /UG = Hs.75774 /LL = 7060 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 thrombospondin 4 (THBS4), 
               
               
                   
                   
                   
                   
                 mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = thrombospondin 4 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_003248.1 
               
               
                 238688_at 
                 −2.37 
                 TPM1 
                 Underexpressed 
                 gb: AI521618 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 4435753 
               
               
                   
                   
                   
                   
                 /DB_XREF = to65f10.x1 
               
               
                   
                   
                   
                   
                 /CLONE = IMAGE: 2183179 
               
               
                   
                   
                   
                   
                 /FEA = EST /CNT = 9 
               
               
                   
                   
                   
                   
                 /TID = Hs.270915.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 4 
               
               
                   
                   
                   
                   
                 /UG = Hs.270915 
               
               
                   
                   
                   
                   
                 /UG_TITLE = ESTs 
               
               
                 217143_s_at 
                 −4.87 
                 TRA@ 
                 Underexpressed 
                 gb: X06557.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 37003 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 2 
               
               
                   
                   
                   
                   
                 /TID = Hs.2014.2 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.2014 /LL = 6964 
               
               
                   
                   
                   
                   
                 /UG_GENE = TRD@ 
               
               
                   
                   
                   
                   
                 /UG_TITLE = T cell receptor 
               
               
                   
                   
                   
                   
                 delta locus /DEF = Human 
               
               
                   
                   
                   
                   
                 mRNA for TCR-delta chain. 
               
               
                 215484_at 
                 2.26 
                 TRIM3 
                 Overexpressed 
                 gb: AF070538.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 3387895 
               
               
                   
                   
                   
                   
                 /FEA = mRNA /CNT = 10 
               
               
                   
                   
                   
                   
                 /TID = Hs.159408.0 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 3 
               
               
                   
                   
                   
                   
                 /UG = Hs.159408 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 clone 24420 mRNA sequence 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  clone 
               
               
                   
                   
                   
                   
                 24420 mRNA sequence. 
               
               
                 1566598_at 
                 2.14 
                 UGT2B7 
                 Overexpressed 
                 gb: AK094928.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 21754091 
               
               
                   
                   
                   
                   
                 /TID = Hs2.269720.2 /CNT = 1 
               
               
                   
                   
                   
                   
                 /FEA = mRNA 
               
               
                   
                   
                   
                   
                 /TIER = ConsEnd /STK = 0 
               
               
                   
                   
                   
                   
                 /UG = Hs.269720 
               
               
                   
                   
                   
                   
                 /UG_TITLE =  Homo sapiens   
               
               
                   
                   
                   
                   
                 cDNA: FLJ22384 fis, clone 
               
               
                   
                   
                   
                   
                 HRC07594. /DEF =  Homo   
               
               
                   
                   
                   
                   
                   sapiens  cDNA FLJ37609 fis, 
               
               
                   
                   
                   
                   
                 clone BRCOC2011010. 
               
               
                 206213_at 
                 2.03 
                 WNT10B 
                 Overexpressed 
                 gb: NM_003394.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 5803222 
               
               
                   
                   
                   
                   
                 /GEN = WNT10B 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 24 
               
               
                   
                   
                   
                   
                 /TID = Hs.91985.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 10 
               
               
                   
                   
                   
                   
                 /UG = Hs.91985 /LL = 7480 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens   
               
               
                   
                   
                   
                   
                 wingless-type MMTV 
               
               
                   
                   
                   
                   
                 integration site family, 
               
               
                   
                   
                   
                   
                 member 10B (WNT10B), 
               
               
                   
                   
                   
                   
                 mRNA. /PROD = wingless- 
               
               
                   
                   
                   
                   
                 type MMTV integration site 
               
               
                   
                   
                   
                   
                 family, member 10B 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_003394.1 
               
               
                   
                   
                   
                   
                 gb: U81787.1 
               
               
                 206067_s_at 
                 −5.27 
                 WT1 
                 Underexpressed 
                 gb: NM_024426.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 13386509 
               
               
                   
                   
                   
                   
                 /GEN = WT1 /FEA = FLmRNA 
               
               
                   
                   
                   
                   
                 /CNT = 24 /TID = Hs.1145.1 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 11 
               
               
                   
                   
                   
                   
                 /UG = Hs.1145 /LL = 7490 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  Wilms 
               
               
                   
                   
                   
                   
                 tumor 1 (WT1), transcript 
               
               
                   
                   
                   
                   
                 variant D, mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = Wilms tumor 1 
               
               
                   
                   
                   
                   
                 isoform D 
               
               
                   
                   
                   
                   
                 /FL = gb: NM_024424.1 
               
               
                   
                   
                   
                   
                 gb: NM_024426.1 
               
               
                 204148_s_at 
                 3.02 
                 ZP3 
                 Overexpressed 
                 gb: NM_012230.1 
               
               
                   
                   
                   
                   
                 /DB_XREF = gi: 6912599 
               
               
                   
                   
                   
                   
                 /GEN = POMZP3 
               
               
                   
                   
                   
                   
                 /FEA = FLmRNA /CNT = 84 
               
               
                   
                   
                   
                   
                 /TID = Hs.296380.0 
               
               
                   
                   
                   
                   
                 /TIER = FL + Stack /STK = 32 
               
               
                   
                   
                   
                   
                 /UG = Hs.296380 /LL = 22932 
               
               
                   
                   
                   
                   
                 /DEF =  Homo sapiens  POM 
               
               
                   
                   
                   
                   
                 (POM121 rat homolog) and 
               
               
                   
                   
                   
                   
                 ZP3 fusion protein 
               
               
                   
                   
                   
                   
                 (POMZP3), mRNA. 
               
               
                   
                   
                   
                   
                 /PROD = POM (POM121 rat 
               
               
                   
                   
                   
                   
                 homolog) and ZP3 fusion 
               
               
                   
                   
                   
                   
                 protein /FL = gb: NM_012230.1 
               
               
                   
                   
                   
                   
                 gb: U10099.1 
               
               
                   
               
               
                 * Probe ID in Affymetrix HU133 Plus 2 GeneChips 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
             
               
             
               
               
               
             
               
             
               
               
               
             
               
             
               
               
               
             
           
               
                 TABLE 6 
               
               
                   
               
               
                 Hypoxia-regulated genes (Banu et al., 2006) 
               
               
                   
               
             
             
               
                 Oxygen Supply 
               
             
          
           
               
                 Probe ID* 
                 Gene Symbol 
                 FC** 
               
               
                   
               
               
                 218120 
                 HO-2 
                 1.09 
               
               
                 218121 
                 HO-2 
                 1.03 
               
               
                 218995 
                 Endothelin-1 
                 1.32 
               
               
                 222802 
                 Endothelin-1 
                 1.41 
               
               
                 1564630 
                 Endothelin-1 
                 −1.30 
               
               
                 202912 
                 Adrenomedullin 
                 −1.16 
               
               
                 207257 
                 EPO 
                 1.36 
               
               
                 217254 
                 EPO 
                 −1.23 
               
               
                 203683 
                 VEGFA 
                 −1.01 
               
               
                 210512 
                 VEGFA 
                 −1.19 
               
               
                 210513 
                 VEGFA 
                 −1.10 
               
               
                 212171 
                 VEGFA 
                 1.04 
               
               
                 203934 
                 Flk-1/KDR/VEGF- 
                 1.16 
               
               
                   
                 R2 
               
               
                 204406 
                 Flt-1/VEGF-R1 
                 1.25 
               
               
                 210287 
                 Flt-1/VEGF-R1 
                 −1.03 
               
               
                 222033 
                 Flt-1/VEGF-R1 
                 1.13 
               
               
                 232809 
                 Flt-1/VEGF-R1 
                 −1.59 
               
               
                 207092 
                 Leptin 
                 −1.43 
               
               
                 208921 
                 Tyrosine 
                 −2.04 
               
               
                   
                 hydroxylase 
               
               
                 201808 
                 Endoglin 
                 −1.19 
               
               
                 201809 
                 Endoglin 
                 −1.01 
               
               
                 228586 
                 Endoglin 
                 2.23 
               
               
                   
               
             
          
           
               
                 Probe ID 
                 Gene Symbol 
                 FC 
               
               
                   
               
             
          
           
               
                 Cellular Metabolism 
               
             
          
           
               
                 202464 
                 PFKFB3 
                 −1.12 
               
               
                 206246 
                 PFKFB4 
                 1.56 
               
               
                 228499 
                 PFKFB4 
                 1.00 
               
               
                 217398 
                 GAPDH 
                 1.11 
               
               
                 212581 
                 GAPDH 
                 1.18 
               
               
                 213453 
                 GAPDH 
                 1.08 
               
               
                 210096 
                 CYP4B1 
                 −1.64 
               
               
                 200650 
                 LDH A 
                 1.01 
               
             
          
           
               
                 Cell Growth and 
               
               
                 Apoptosis 
               
             
          
           
               
                 209201 
                 CXCR4 
                 1.12 
               
               
                 211919 
                 CXCR4 
                 1.15 
               
               
                 217028 
                 CXCR4 
                 1.09 
               
               
                 205302 
                 IGFBP-1 
                 −50.00 
               
               
                 237989 
                 IGFBP-1 
                 −1.69 
               
               
                 209101 
                 CTGF 
                 −1.07 
               
               
                 206067 
                 WT-1 
                 −5.26 
               
               
                 216953 
                 WT-1 
                 −1.23 
               
               
                 1555271 
                 TERT 
                 −1.12 
               
               
                 207199 
                 TERT 
                 −1.61 
               
               
                 211599 
                 met 
                 −1.07 
               
               
                 213816 
                 met 
                 −1.20 
               
               
                 213807 
                 met 
                 −1.15 
               
             
          
           
               
                 Others 
               
             
          
           
               
                 201945 
                 Furin 
                 1.24 
               
               
                 220781 
                 DEC1 
                 −1.15 
               
               
                 213931 
                 IDA2/ID2B 
                 −1.28 
               
               
                 207980 
                 Cited 2 
                 1.05 
               
               
                 209357 
                 Cited 2 
                 −1.06 
               
               
                 227287 
                 Cited 2 
                 −1.22 
               
               
                 160020 
                 MMP-14 
                 −1.05 
               
               
                 202827 
                 MMP-14 
                 −1.11 
               
               
                 202828 
                 MMP-14 
                 1.08 
               
               
                 217279 
                 MMP-14 
                 1.21 
               
               
                   
               
               
                 *Probe ID in Affymetrix HU133 Plus 2 GeneChip 
               
               
                 **FC = Fold Change ±2 considered significant 
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
             
               
             
               
               
               
             
               
             
               
               
               
             
           
               
                 TABLE 7 
               
               
                   
               
               
                 Probe ID* 
                 Gene Symbol 
                 FC** 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Putative HIF-2α regulated genes (Liu et al., 2000) 
               
             
          
           
               
                 206702 
                 TIE-2/TEK tyrosine kinase 
                 1.15 
               
               
                 217711 
                 TIE-2/TEK tyrosine kinase 
                 −1.01 
               
               
                 203934 
                 Flk-1/KDR/VEGF-R2 
                 1.16 
               
               
                 1562263 
                 Lysyl oxidase-like-2/LOXL2 
                 −1.61 
               
               
                 202997 
                 Lysyl oxidase-like-2/LOXL2 
                 1.10 
               
               
                 202998 
                 Lysyl oxidase-like-2/LOXL2 
                 −1.05 
               
               
                 202999 
                 Lysyl oxidase-like-2/LOXL2 
                 1.20 
               
               
                 204298 
                 Lysyl oxidase/LOX 
                 −1.06 
               
               
                 215446 
                 Lysyl oxidase/LOX 
                 −1.12 
               
               
                 209357 
                 CITED2 
                 −1.06 
               
               
                 227287 
                 CITED2 
                 −1.22 
               
               
                 207980 
                 CITED2 
                 1.05 
               
               
                 203683 
                 VEGFA 
                 −1.01 
               
               
                 210512 
                 VEGFA 
                 −1.84 
               
               
                 210513 
                 VEGFA 
                 −1.10 
               
               
                 212171 
                 VEGFA 
                 1.04 
               
               
                 207257 
                 EPO 
                 1.36 
               
               
                 217254 
                 EPO 
                 −1.23 
               
               
                 160020 
                 MMP-14 
                 −1.05 
               
               
                 202827 
                 MMP-14 
                 −1.11 
               
               
                 202828 
                 MMP-14 
                 1.08 
               
               
                 217279 
                 MMP-14 
                 1.21 
               
               
                 210265 
                 Oct-4 
                 −2.94 
               
               
                 205015 
                 TGF-α 
                 −2.78 
               
               
                 211258 
                 TGF-α 
                 1.30 
               
             
          
           
               
                 Oxidative stress-regulated genes (Schwaeble et al., 1991) 
               
             
          
           
               
                 200642 
                 SOD 1 soluble 
                 −1.04 
               
               
                 205236 
                 SOD 3 extracellular 
                 1.06 
               
               
                 200800 
                 Heat shock 70 KDa protein 
                 1.03 
               
               
                   
                 HSPA1A///HSPA1B 
               
               
                 201841 
                 Heat shock 27 Kda protein 7 
                 −1.06 
               
               
                 202581 
                 Heat shock 70 Kda protein 1B 
                 1.11 
               
               
                 203751 
                 JUN D proto-oncogene 
                 1.20 
               
               
                 203752 
                 JUN D proto-oncogene 
                 1.08 
               
               
                 214326 
                 JUN D proto-oncogene 
                 1.23 
               
               
                 208864 
                 Thioredoxin 
                 −1.04 
               
               
                 216609 
                 Thioredoxin 
                 1.14 
               
               
                 209077 
                 Thioredoxin 2 
                 1.10 
               
               
                 209078 
                 Thioredoxin 2 
                 −1.02 
               
               
                 211300 
                 p53 
                 −1.05 
               
               
                 201746 
                 p53 
                 1.04 
               
               
                 215078 
                 SOD 2 mitochondrial 
                 1.55 
               
               
                 215223 
                 SOD 2 mitochondrial 
                 −1.27 
               
               
                 216841 
                 SOD 2 mitochondrial 
                 −1.43 
               
               
                 216336 
                 Metallothioein 1A///1M 
                 −1.04 
               
               
                 218120 
                 HO 2 
                 1.09 
               
               
                 218121 
                 HO 2 
                 1.03 
               
               
                   
               
               
                 *Probe ID in Affymetrix HU133 Plus 2 Genechip 
               
               
                 **FC = Fold Change ±2 considered significant 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                 J5 and Fold Change Genes that Secrete or Shed Proteins 
               
               
                 (certain genes have both fold change and J5 values (bold)) 
               
             
          
           
               
                   
                   
                   
                   
                   
                 Expression 
               
               
                 GeneSym 
                 GeneName 
                 Compartment 
                 ProbeID 
                 FC_J5 
                 Profile 
               
               
                   
               
             
          
           
               
                 ACACA 
                 acetyl-Coenzyme A 
                 Cytoplasm 
                 214358_at 
                 −2.12 
                 Underexpressed 
               
               
                   
                 carboxylase alpha 
               
               
                 AHSG 
                 alpha-2-HS- 
                 Extracellular 
                 210929_s_at 
                 2.39 
                 Overexpressed 
               
               
                   
                 glycoprotein 
                 Space 
               
               
                 ALDH1A2 
                 aldehyde 
                 Cytoplasm 
                 207016_s_at 
                 −7.83 
                 Underexpressed 
               
               
                   
                 dehydrogenase 1 
               
               
                   
                 family, member A2 
               
               
                 ANXA13 
                 annexin A13 
                 Plasma 
                 208323_s_at 
                 2.89 
                 Overexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 APC 
                 adenomatous polyposis 
                 Nucleus 
                 203527_s_at 
                 −2.58 
                 Underexpressed 
               
               
                   
                 coli 
               
               
                 ARFGEF2 
                 ADP-ribosylation 
                 Cytoplasm 
                 239373_at 
                 3.41 
                 Overexpressed 
               
               
                   
                 factor guanine 
               
               
                   
                 nucleotide-exchange 
               
               
                   
                 factor 2 (brefeldin A- 
               
               
                   
                 inhibited) 
               
               
                 ART1 
                 ADP- 
                 Plasma 
                 207919_at 
                 −2.2 
                 Underexpressed 
               
               
                   
                 ribosyltransferase 1 
                 Membrane 
               
               
                 BDKRB2 
                 bradykinin receptor B2 
                 Plasma 
                 205870_at 
                 −2.7 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 C4BPA 
                 complement 
                 Extracellular 
                 205654_at 
                 −2.67 
                 Underexpressed 
               
               
                   
                 component 4 binding 
                 Space 
               
               
                   
                 protein, alpha 
               
               
                 CCK 
                 cholecystokinin 
                 Extracellular 
                 205827_at 
                 4.46 
                 Overexpressed 
               
               
                   
                   
                 Space 
               
               
                 CCK 
                 cholecystokinin 
                 Extracellular 
                 205827_at 
                 
                   20.41 
                 
                 Overexpressed 
               
               
                   
                   
                 Space 
               
               
                 CD52 
                 CD52 molecule 
                 Plasma 
                 34210_at 
                 2.42 
                 Overexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 CFHR1 
                 complement factor H- 
                 Extracellular 
                 215388_s_at 
                 
                   −8.449 
                 
                 Underexpressed 
               
               
                   
                 related 1 
                 Space 
               
               
                 CEHR1 
                 complement factor H- 
                 Extracellular 
                 215388_s_at 
                 −3.48 
                 Underexpressed 
               
               
                   
                 related 1 
                 Space 
               
               
                 COL5A1 
                 collagen, type V, alpha 1 
                 Extracellular 
                 213818_x_at 
                 2.12 
                 Overexpressed 
               
               
                   
                   
                 Space 
               
               
                 CPM 
                 carboxypeptidase M 
                 Plasma 
                 235019_at 
                 −2.06 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 CR1 
                 complement 
                 Plasma 
                 217552_x_at 
                 2 
                 Overexpressed 
               
               
                   
                 component (3b/4b) 
                 Membrane 
               
               
                   
                 receptor 1 (Knops 
               
               
                   
                 blood group) 
               
               
                 CUL1 
                 cullin 1 
                 Nucleus 
                 243286_at 
                 −2.01 
                 Underexpressed 
               
               
                 CXCL9 
                 chemokine (C—X—C 
                 Extracellular 
                 203915_at 
                 2.07 
                 Overexpressed 
               
               
                   
                 motif) ligand 9 
                 Space 
               
               
                 DPYSL4 
                 dihydropyrimidinase- 
                 Cytoplasm 
                 205493_s_at 
                 2.01 
                 Overexpressed 
               
               
                   
                 like 4 
               
               
                 EGR1 
                 early growth response 1 
                 Nucleus 
                 227404_s_at 
                 2.37 
                 Overexpressed 
               
               
                 EPAS1 
                 endothelial PAS 
                 Nucleus 
                 242868_at 
                 
                   −15.342 
                 
                 Underexpressed 
               
               
                   
                 domain protein 1 
               
               
                 EPAS1 
                 endothelial PAS 
                 Nucleus 
                 242868_at 
                 −7.64 
                 Underexpressed 
               
               
                   
                 domain protein 1 
               
               
                 F11R 
                 F11 receptor 
                 Plasma 
                 226482_s_at 
                 −8.441 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 F2R 
                 coagulation factor II 
                 Plasma 
                 203989_x_at 
                 −2.98 
                 Underexpressed 
               
               
                   
                 (thrombin) receptor 
                 Membrane 
               
               
                 FKBP1A 
                 FK506 binding protein 
                 Cytoplasm 
                 239248_at 
                 2.1 
                 Overexpressed 
               
               
                   
                 1A, 12 kDa 
               
               
                 FLT4 
                 fms-related tyrosine 
                 Plasma 
                 229902_at 
                 −2.12 
                 Underexpressed 
               
               
                   
                 kinase 4 
                 Membrane 
               
               
                 FN1 
                 fibronectin 1 
                 Plasma 
                 214702_at 
                 
                   −8.2 
                 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 FN1 
                 fibronectin 1 
                 Plasma 
                 214702_at 
                 −2.35 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 FOS 
                 v-fos FBJ murine 
                 Nucleus 
                 209189_at 
                 2.78 
                 Overexpressed 
               
               
                   
                 osteosarcoma viral 
               
               
                   
                 oncogene homolog 
               
               
                 FOSB 
                 FBJ murine 
                 Nucleus 
                 202768_at 
                 2.33 
                 Overexpressed 
               
               
                   
                 osteosarcoma viral 
               
               
                   
                 oncogene homolog B 
               
               
                 FPRL2 
                 formyl peptide 
                 Plasma 
                 214560_at 
                 2 
                 Overexpressed 
               
               
                   
                 receptor 3 
                 Membrane 
               
               
                 FSTL3 
                 follistatin-like 3 
                 Extracellular 
                 203592_s_at 
                 
                   −10.048 
                 
                 Underexpressed 
               
               
                   
                 (secreted glycoprotein) 
                 Space 
               
               
                 FSTL3 
                 follistatin-like 3 
                 Extracellular 
                 203592_s_at 
                 −2.56 
                 Underexpressed 
               
               
                   
                 (secreted glycoprotein) 
                 Space 
               
               
                 FUT6 
                 fucosyltransferase 6 
                 Cytoplasm 
                 1565661_x_at 
                 2.02 
                 Overexpressed 
               
               
                   
                 (alpha (1,3) 
               
               
                   
                 fucosyltransferase) 
               
               
                 GATA1 
                 GATA binding protein 
                 Nucleus 
                 1555590_a_at 
                 −2.47 
                 Underexpressed 
               
               
                   
                 1 (globin transcription 
               
               
                   
                 factor 1) 
               
               
                 GNG4 
                 guanine nucleotide 
                 Plasma 
                 1555765_a_at 
                 −3.73 
                 Underexpressed 
               
               
                   
                 binding protein (G 
                 Membrane 
               
               
                   
                 protein), gamma 4 
               
               
                 GNG7 
                 guanine nucleotide 
                 Plasma 
                 232043_at 
                 −2.67 
                 Underexpressed 
               
               
                   
                 binding protein (G 
                 Membrane 
               
               
                   
                 protein), gamma 7 
               
               
                 GNLY 
                 granulysin 
                 Cytoplasm 
                 205495_s_at 
                 −23.51 
                 Underexpressed 
               
               
                 GTPBP2 
                 GTP binding protein 2 
                 Unknown 
                 223789_s_at 
                 −2.17 
                 Underexpressed 
               
               
                 GZMB 
                 granzyme B 
                 Cytoplasm 
                 210164_at 
                 −2.7 
                 Underexpressed 
               
               
                   
                 (granzyme 2, cytotoxic 
               
               
                   
                 T-lymphocyte- 
               
               
                   
                 associated serine 
               
               
                   
                 esterase 1) 
               
               
                 HBE1 
                 hemoglobin, epsilon 1 
                 Cytoplasm 
                 205919_at 
                 −2.64 
                 Underexpressed 
               
               
                 HBZ 
                 hemoglobin, zeta 
                 Cytoplasm 
                 206647_at 
                 −6.51 
                 Underexpressed 
               
               
                 HEXA 
                 hexosaminidase A 
                 Cytoplasm 
                 1556426_at 
                 2.46 
                 Overexpressed 
               
               
                   
                 (alpha polypeptide) 
               
               
                 HLA- 
                 major 
                 Plasma 
                 203290_at 
                 2.21 
                 Overexpressed 
               
               
                 DQA1 
                 histocompatibility 
                 Membrane 
               
               
                   
                 complex, class II, DQ 
               
               
                   
                 alpha 1 
               
               
                 HTR2B 
                 5-hydroxytryptamine 
                 Plasma 
                 206638_at 
                 −2.51 
                 Underexpressed 
               
               
                   
                 (serotonin) receptor 2B 
                 Membrane 
               
               
                 IGFBP1 
                 insulin-like growth 
                 Extracellular 
                 205302_at 
                 −53.23 
                 Underexpressed 
               
               
                   
                 factor binding protein 1 
                 Space 
               
               
                 IGEBP1 
                 insulin-like growth 
                 Extracellular 
                 205302_at 
                 
                   −10.347 
                 
                 Underexpressed 
               
               
                   
                 factor binding protein 1 
                 Space 
               
               
                 IKZF1 
                 IKAROS family zinc 
                 Nucleus 
                 205038_at 
                 2.06 
                 Overexpressed 
               
               
                   
                 finger 1 (Ikaros) 
               
               
                 IL15 
                 interleukin 15 
                 Extracellular 
                 205992_s_at 
                 −2.76 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 IL1B 
                 interleukin 1, beta 
                 Extracellular 
                 205067_at 
                 −2.14 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 IL1RL1 
                 interleukin 1 receptor- 
                 Plasma 
                 207526_s_at 
                 −2.93 
                 Underexpressed 
               
               
                   
                 like 1 
                 Membrane 
               
               
                 IL2RB 
                 interleukin 2 receptor, 
                 Plasma 
                 205291_at 
                 −2.77 
                 Underexpressed 
               
               
                   
                 beta 
                 Membrane 
               
               
                 KCNH2 
                 potassium voltage- 
                 Plasma 
                 210036_s_at 
                 −2.06 
                 Underexpressed 
               
               
                   
                 gated channel, 
                 Membrane 
               
               
                   
                 subfamily H (eag- 
               
               
                   
                 related), member 2 
               
               
                 KCNIP3 
                 Kv channel interacting 
                 Nucleus 
                 231774_at 
                 −2.42 
                 Underexpressed 
               
               
                   
                 protein 3, calsenilin 
               
               
                 KLRC2 
                 killer cell lectin-like 
                 Plasma 
                 206785_s_at 
                 −2.86 
                 Underexpressed 
               
               
                   
                 receptor subfamily C, 
                 Membrane 
               
               
                   
                 member 2 
               
               
                 KRT14 
                 keratin 14 
                 Cytoplasm 
                 209351_at 
                 
                   −8.699 
                 
                 Underexpressed 
               
               
                 (includes 
                 (epidermolysis bullosa 
               
               
                 EG: 3861) 
                 simplex, Dowling- 
               
               
                   
                 Meara, Koebner) 
               
               
                 KRT14 
                 keratin 14 
                 Cytoplasm 
                 209351_at 
                 −2.85 
                 Underexpressed 
               
               
                 (includes 
                 (epidermolysis bullosa 
               
               
                 EG: 3861) 
                 simplex, Dowling- 
               
               
                   
                 Meara, Koebner) 
               
               
                 LIPH 
                 lipase, member H 
                 Extracellular 
                 235871_at 
                 −2.91 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 LSS 
                 lanosterol synthase 
                 Cytoplasm 
                 211018_at 
                 −2.14 
                 Underexpressed 
               
               
                   
                 (2,3-oxidosqualene- 
               
               
                   
                 lanosterol cyclase) 
               
               
                 LTBR 
                 lymphotoxin beta 
                 Plasma 
                 232819_s_at 
                 −2.81 
                 Underexpressed 
               
               
                   
                 receptor (TNFR 
                 Membrane 
               
               
                   
                 superfamily, member 
               
               
                   
                 3) 
               
               
                 MAP2K7 
                 mitogen-activated 
                 Cytoplasm 
                 226023_at 
                 2.69 
                 Overexpressed 
               
               
                   
                 protein kinase kinase 7 
               
               
                 MMP12 
                 matrix 
                 Extracellular 
                 204580_at 
                 
                   −17.183 
                 
                 Underexpressed 
               
               
                   
                 metallopeptidase 12 
                 Space 
               
               
                   
                 (macrophage elastase) 
               
               
                 MMP12 
                 matrix 
                 Extracellular 
                 204580_at 
                 −6.06 
                 Underexpressed 
               
               
                   
                 metallopeptidase 12 
                 Space 
               
               
                   
                 (macrophage elastase) 
               
               
                 MSR1 
                 macrophage scavenger 
                 Plasma 
                 208423_s_at 
                 2.44 
                 Overexpressed 
               
               
                   
                 receptor 1 
                 Membrane 
               
               
                 MYL9 
                 myosin, light chain 9, 
                 Cytoplasm 
                 244149_at 
                 2.13 
                 Overexpressed 
               
               
                 (includes 
                 regulatory 
               
               
                 EG: 10398) 
               
               
                 NOG 
                 noggin 
                 Extracellular 
                 231798_at 
                 −5.28 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 PAEP 
                 progestagen-associated 
                 Extracellular 
                 206859_s_at 
                 
                   −15.642 
                 
                 Underexpressed 
               
               
                   
                 endometrial protein 
                 Space 
               
               
                   
                 (placental protein 14, 
               
               
                   
                 pregnancy-associated 
               
               
                   
                 endometrial alpha-2- 
               
               
                   
                 globulin, alpha uterine 
               
               
                   
                 protein) 
               
               
                 PAEP 
                 progestagen-associated 
                 Extracellular 
                 206859_s_at 
                 −10.02 
                 Underexpressed 
               
               
                   
                 endometrial protein 
                 Space 
               
               
                   
                 (placental protein 14, 
               
               
                   
                 pregnancy-associated 
               
               
                   
                 endometrial alpha-2- 
               
               
                   
                 globulin, alpha uterine 
               
               
                   
                 protein) 
               
               
                 PDE4C 
                 phosphodiesterase 4C, 
                 Cytoplasm 
                 211818_s_at 
                 −3.42 
                 Underexpressed 
               
               
                   
                 cAMP-specific 
               
               
                   
                 (phosphodiesterase E1 
               
               
                   
                 dunce homolog, 
               
               
                   
                   Drosophila ) 
               
               
                 PRDM1 
                 PR domain containing 
                 Nucleus 
                 228964_at 
                 −2.75 
                 Underexpressed 
               
               
                   
                 1, with ZNF domain 
               
               
                 PRG2 
                 proteoglycan 2, bone 
                 Extracellular 
                 211743_s_at 
                 −4.67 
                 Underexpressed 
               
               
                 (includes 
                 marrow (natural killer 
                 Space 
               
               
                 EG: 5553) 
                 cell activator, 
               
               
                   
                 eosinophil granule 
               
               
                   
                 major basic protein) 
               
               
                 PRL 
                 prolactin 
                 Extracellular 
                 205445_at 
                 −7.86 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 PTPRS 
                 protein tyrosine 
                 Plasma 
                 210823_s_at 
                 −2.29 
                 Underexpressed 
               
               
                   
                 phosphatase, receptor 
                 Membrane 
               
               
                   
                 type, S 
               
               
                 RBP4 
                 retinol binding protein 
                 Extracellular 
                 219140_s_at 
                 −3.94 
                 Underexpressed 
               
               
                   
                 4, plasma 
                 Space 
               
               
                 RHD 
                 Rh blood group, D 
                 Plasma 
                 210586_x_at 
                 −6.11 
                 Underexpressed 
               
               
                   
                 antigen 
                 Membrane 
               
               
                 S100A12 
                 S100 calcium binding 
                 Cytoplasm 
                 205863_at 
                 2.7 
                 Overexpressed 
               
               
                   
                 protein A12 
               
               
                 S100A8 
                 S100 calcium binding 
                 Cytoplasm 
                 202917_s_at 
                 3.2 
                 Overexpressed 
               
               
                   
                 protein A8 
               
               
                 S100A8 
                 S100 calcium binding 
                 Cytoplasm 
                 202917_s_at 
                 
                   13.185 
                 
                 Overexpressed 
               
               
                   
                 protein A8 
               
               
                 SART3 
                 squamous cell 
                 Nucleus 
                 1554276_at 
                 −13.803 
                 Underexpressed 
               
               
                   
                 carcinoma antigen 
               
               
                   
                 recognized by T cells 3 
               
               
                 SEMA3C 
                 sema domain, 
                 Extracellular 
                 203789_s_at 
                 
                   −8.419 
                 
                 Underexpressed 
               
               
                   
                 immunoglobulin 
                 Space 
               
               
                   
                 domain (Ig), short basic 
               
               
                   
                 domain, secreted, 
               
               
                   
                 (semaphorin) 3C 
               
               
                 SEMA3C 
                 sema domain, 
                 Extracellular 
                 203789_s_at 
                 −2.15 
                 Underexpressed 
               
               
                   
                 immunoglobulin 
                 Space 
               
               
                   
                 domain (Ig), short basic 
               
               
                   
                 domain, secreted, 
               
               
                   
                 (semaphorin) 3C 
               
               
                 SERPINA3 
                 serpin peptidase 
                 Extracellular 
                 202376_at 
                 −12.84 
                 Underexpressed 
               
               
                   
                 inhibitor, clade A 
                 Space 
               
               
                   
                 (alpha-1 antiproteinase, 
               
               
                   
                 antitrypsin), member 3 
               
               
                 SLC16A6 
                 solute carrier family 
                 Plasma 
                 230748_at 
                 −8.374 
                 Underexpressed 
               
               
                   
                 16, member 6 
                 Membrane 
               
               
                   
                 (monocarboxylic acid 
               
               
                   
                 transporter 7) 
               
               
                 SLC2A3 
                 solute carrier family 2 
                 Plasma 
                 202498_s_at 
                 −2.33 
                 Underexpressed 
               
               
                   
                 (facilitated glucose 
                 Membrane 
               
               
                   
                 transporter), member 3 
               
               
                 SRF 
                 serum response factor 
                 Nucleus 
                 202400_s_at 
                 2.35 
                 Overexpressed 
               
               
                   
                 (c-fos serum response 
               
               
                   
                 element-binding 
               
               
                   
                 transcription factor) 
               
               
                 SSTR1 
                 somatostatin receptor 1 
                 Plasma 
                 235591_at 
                 −2.84 
                 Underexpressed 
               
               
                   
                   
                 Membrane 
               
               
                 STXBP2 
                 syntaxin binding 
                 Unknown 
                 1570420_at 
                 2.25 
                 Overexpressed 
               
               
                   
                 protein 2 
               
               
                 THBS4 
                 thrombospondin 4 
                 Extracellular 
                 204776_at 
                 −3.94 
                 Underexpressed 
               
               
                   
                   
                 Space 
               
               
                 TPM1 
                 tropomyosin 1 (alpha) 
                 Cytoplasm 
                 238688_at 
                 −2.37 
                 Underexpressed 
               
               
                 TRA@ 
                 T cell receptor alpha 
                 Cytoplasm 
                 217143_s_at 
                 −4.87 
                 Underexpressed 
               
               
                   
                 locus 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                 Genes differentially expressed in first trimester PE 
               
             
          
           
               
                   
                   
                   
                 Gene Symbol 
                   
                 Localization and 
               
               
                   
                   
                   
                 &amp; MIM 
                 GO Biological 
                 Function of Immune- 
               
               
                 Probe Set ID 
                 J5 Score 
                 Gene Title 
                 Number 
                 Process/Description 
                 related Genes 
               
               
                   
               
             
          
           
               
                 205827_at 
                 20.41 
                 Cholecystokinin 
                 CCK 
                 Neuron migration /// 
                   
               
               
                   
                   
                   
                 118440 
                 signal transduction /// 
               
               
                   
                   
                   
                   
                 axonogenesis /// eating 
               
               
                   
                   
                   
                   
                 behavior 
               
               
                 215141_at 
                 13.77 
                 chromosome 4 
                 C4orf10 
                 — 
               
               
                   
                   
                 open reading frame 
               
               
                   
                   
                 10 
               
               
                 202917_s_at 
                 13.19 
                 S100 calcium 
                 S100A8 
                 inflammatory response 
                 Chorionic villi, 
               
               
                   
                   
                 binding protein A8 
                 123885 
                   
                 monocytes, 
               
               
                   
                   
                   
                   
                   
                 macrophages, epithelial 
               
               
                   
                   
                   
                   
                   
                 cells; chronic 
               
               
                   
                   
                   
                   
                   
                 inflammation; cystic 
               
               
                   
                   
                   
                   
                   
                 fibrosis antigen 
               
               
                   
                   
                   
                   
                   
                 (1 related to HELLP) 
               
               
                 215733_x_at 
                 8.52 
                 cancer/testis 
                 CTAG2 
                 biological_process 
               
               
                   
                   
                 antigen 2 
                 300396 
               
               
                 234601_x_at 
                 8.37 
                 CDNA: FLJ22732 
                 —* 
                 — 
               
               
                   
                   
                 fis, clone HSI15880 
               
               
                 227238_at 
                 −8.01 
                 mucin 15, cell 
                 MUC15 
                 — 
               
               
                   
                   
                 surface associated 
                 608566 
               
               
                 239010_at 
                 −8.13 
                 Hypothetical gene 
                 LOC440157 
                 — 
               
               
                   
                   
                 supported by 
               
               
                   
                   
                 AK096951; 
               
               
                   
                   
                 BC066547 
               
               
                 214702_at 
                 −8.20 
                 fibronectin 1 
                 FN1 
                 acute-phase response /// 
                 plasma, epithelial cell 
               
               
                   
                   
                   
                 135600 
                 cell adhesion /// 
                 surface, extracellular 
               
               
                   
                   
                   
                   
                 transmembrane receptor 
                 matrix (ECM); 
               
               
                   
                   
                   
                   
                 protein tyrosine kinase 
                 migration stimulating 
               
               
                   
                   
                   
                   
                 signaling pathway /// 
                 factor, inflammation, 
               
               
                   
                   
                   
                   
                 metabolism /// response 
                 binds collagen, binds 
               
               
                   
                   
                   
                   
                 to wounding /// cell 
                 complement, stimulates 
               
               
                   
                   
                   
                   
                 migration /// cell 
                 endocytosis and 
               
               
                   
                   
                   
                   
                 adhesion 
                 clearance of particulate 
               
               
                   
                   
                   
                   
                   
                 material from the 
               
               
                   
                   
                   
                   
                   
                 circulation 
               
               
                 1553319_at 
                 −8.25 
                 oxoglutarate (alpha- 
                 OXGR1 
                 signal transduction /// 
               
               
                   
                   
                 ketoglutarate) 
                 606922 
                 G-protein coupled 
               
               
                   
                   
                 receptor 1 
                   
                 receptor protein 
               
               
                   
                   
                   
                   
                 signaling pathway /// G- 
               
               
                   
                   
                   
                   
                 protein coupled 
               
               
                   
                   
                   
                   
                 receptor protein 
               
               
                   
                   
                   
                   
                 signaling pathway 
               
               
                 235592_at 
                 −8.25 
                 Elongation factor, 
                 ELL2 
                 transcription /// 
               
               
                   
                   
                 RNA polymerase 
                 601874 
                 regulation of 
               
               
                   
                   
                 II, 2 
                   
                 transcription, DNA- 
               
               
                   
                   
                   
                   
                 dependent /// RNA 
               
               
                   
                   
                   
                   
                 elongation from RNA 
               
               
                   
                   
                   
                   
                 polymerase II promoter 
               
               
                 229839_at 
                 −8.30 
                 Scavenger receptor 
                 SCARA5 
                 phosphate transport 
               
               
                   
                   
                 class A, member 5 
                 611306 
               
               
                   
                   
                 (putative) 
               
               
                 230748_at 
                 −8.37 
                 solute carrier 
                 SLC16A6 
                 transport /// 
               
               
                   
                   
                 family 16, member 
                 603880 
                 monocarboxylic acid 
               
               
                   
                   
                 6 (monocarboxylic 
                   
                 transport 
               
               
                   
                   
                 acid transporter 7) 
               
               
                 203789_s_at 
                 −8.42 
                 sema domain, 
                 SEMA3C 
                 immune response /// 
                 axons; 
               
               
                   
                   
                 immunoglobulin 
                 602645 
                 transmembrane receptor 
                 secreted Ig; 
               
               
                   
                   
                 domain (Ig), short 
                   
                 protein tyrosine kinase 
                 integrin inhibition 
               
               
                   
                   
                 basic domain, 
                   
                 signaling pathway /// 
               
               
                   
                   
                 secreted, 
                   
                 development /// 
               
               
                   
                   
                 (semaphorin) 3C 
                   
                 response to drug 
               
               
                 226482_s_at 
                 −8.44 
                 F11 receptor 
                 F11R 
                 cell motility /// 
                 tight junctions of 
               
               
                   
                   
                   
                 605721 
                 inflammatory response 
                 epithelial and 
               
               
                   
                   
                   
                   
                 /// cell adhesion /// 
                 endothelial cells, 
               
               
                   
                   
                   
                   
                 epithelial cell 
                 hematopoietic cells; 
               
               
                   
                   
                   
                   
                 differentiation 
                 tight junction assembly 
               
               
                   
                   
                   
                   
                   
                 and stabilization, 
               
               
                   
                   
                   
                   
                   
                 leukocyte 
               
               
                   
                   
                   
                   
                   
                 transmigration, and 
               
               
                   
                   
                   
                   
                   
                 platelet activation 
               
               
                 215388_s_at 
                 −8.45 
                 complement factor 
                 CFH /// 
                 complement activation, 
                 liver, monocytes, 
               
               
                   
                   
                 H /// complement 
                 CFHR1 
                 alternative pathway /// 
                 human umbilical vein 
               
               
                   
                   
                 factor H-related 1 
                 134370 /// 
                 complement activation 
                 endothelial cells 
               
               
                   
                   
                   
                 134371 /// 
                 /// immune response /// 
                 (HUVEC), fibroblasts, 
               
               
                   
                   
                   
                 235400 /// 
                 innate immune response 
                 placenta; 
               
               
                   
                   
                   
                 609814 /// 
                   
                 alternative complement 
               
               
                   
                   
                   
                 610698 
                   
                 pathway in innate 
               
               
                   
                   
                   
                   
                   
                 immune system 
               
               
                   
                   
                   
                   
                   
                 (1 postpartum case 
               
               
                   
                   
                   
                   
                   
                 study) 
               
               
                 1562053_at 
                 −8.58 
                 CDNA clone 
                 — 
                 — 
               
               
                   
                   
                 IMAGE: 5267797 
               
               
                 219911_s_at 
                 −8.59 
                 solute carrier 
                 SLCO4A1 
                 ion transport /// 
               
               
                   
                   
                 organic anion 
                   
                 transport 
               
               
                   
                   
                 transporter family, 
               
               
                   
                   
                 member 4A1 
               
               
                 209351_at 
                 −8.70 
                 keratin 14 
                 KRT14 
                 cell morphogenesis /// 
               
               
                   
                   
                 (epidermolysis 
                 125595 /// 
                 biological_process /// 
               
               
                   
                   
                 bullosa simplex, 
                 131800 /// 
                 epidermis development 
               
               
                   
                   
                 Dowling-Meara, 
                 148066 /// 
                 /// epidermis 
               
               
                   
                   
                 Koebner) 
                 161000 /// 
                 development 
               
               
                   
                   
                   
                 601001 
               
               
                 1552858_at 
                 −8.92 
                 melanoma antigen 
                 MAGEB6 
                 biological_process 
               
               
                   
                   
                 family B, 6 
               
               
                   
                   
                 300467 
               
               
                 215108_x_at 
                 −8.95 
                 trinucleotide repeat 
                 TNRC9 
                 regulation of 
               
               
                   
                   
                 containing 9 
                   
                 transcription, DNA- 
               
               
                   
                   
                 611416 
                   
                 dependent 
               
               
                 226403_at 
                 −8.97 
                 transmembrane 
                 TMC4 
                 — 
               
               
                   
                   
                 channel-like 4 
               
               
                 207607_at 
                 −9.23 
                 achaete-scute 
                 ASCL2 
                 regulation of 
               
               
                   
                   
                 complex homolog 2 
                 601886 
                 transcription, DNA- 
               
               
                   
                   
                 ( Drosophila ) 
                   
                 dependent /// 
               
               
                   
                   
                   
                   
                 central nervous system 
               
               
                   
                   
                   
                   
                 development /// 
               
               
                   
                   
                   
                   
                 peripheral nervous 
               
               
                   
                   
                   
                   
                 system development /// 
               
               
                   
                   
                   
                   
                 cell differentiation /// 
               
               
                   
                   
                   
                   
                 regulation of 
               
               
                   
                   
                   
                   
                 transcription 
               
               
                 228293_at 
                 −9.41 
                 DEP domain 
                 DEPDC7 
                 intracellular signaling 
               
               
                   
                   
                 containing 7 
                   
                 cascade /// 
               
               
                   
                   
                   
                   
                 biological_process 
               
               
                 210251_s_at 
                 −9.55 
                 RUN and FYVE 
                 RUFY3 
                 — 
               
               
                   
                   
                 domain containing 3 
                 611194 
               
               
                 1561318_at 
                 −9.69 
                 CDNA clone 
                 — 
                 — 
               
               
                   
                   
                 IMAGE: 5287025 
               
               
                 241036_at 
                 −9.76 
                 Hermansky-Pudlak 
                 HPS3 
                 organelle organization 
                 kidney, liver placental 
               
               
                   
                   
                 syndrome 3 
                 606118 
                 and biogenesis 
                 cells; 
               
               
                   
                   
                   
                   
                   
                 lysosomal vesicles, 
               
               
                   
                   
                   
                   
                   
                 platelet storage 
               
               
                   
                   
                   
                   
                   
                 deficiency 
               
               
                 219759_at 
                 −9.92 
                 leukocyte-derived 
                 LRAP 
                 proteolysis /// blood 
                 endoplasmic reticulum; 
               
               
                   
                   
                 arginine 
                 609497 
                 pressure regulation /// 
                 maintenance of 
               
               
                   
                   
                 aminopeptidase 
                   
                 antigen processing and 
                 homeostasis, 
               
               
                   
                   
                   
                   
                 presentation of 
                 maintenance of normal 
               
               
                   
                   
                   
                   
                 endogenous peptide 
                 pregnancy, memory 
               
               
                   
                   
                   
                   
                 antigen via MHC class I 
                 retention, blood 
               
               
                   
                   
                   
                   
                   
                 pressure regulation, 
               
               
                   
                   
                   
                   
                   
                 antigen presentation 
               
               
                 203592_s_at 
                 −10.05 
                 follistatin-like 3 
                 FSTL3 
                 negative regulation of 
               
               
                   
                   
                 (secreted 
                 605343 
                 BMP signaling pathway 
               
               
                   
                   
                 glycoprotein) 
               
               
                 205302_at 
                 −10.35 
                 insulin-like growth 
                 IGFBP1 
                 regulation of cell 
                 liver, secretory 
               
               
                   
                   
                 factor binding 
                 146730 
                 growth /// signal 
                 endometrium, and 
               
               
                   
                   
                 protein 1 
                   
                 transduction 
                 decidua; 
               
               
                   
                   
                   
                   
                   
                 decidualization and 
               
               
                   
                   
                   
                   
                   
                 trophoblast invasion 
               
               
                 1568554_x_at 
                 −10.67 
                 Chromosome 6 
                 C6orf142 
                 — 
               
               
                   
                   
                 open reading frame 
               
               
                   
                   
                 142 
               
               
                 1554276_at 
                 −13.80 
                 squamous cell 
                 SART3 
                 RNA processing 
                 RNA-binding nuclear 
               
               
                   
                   
                 carcinoma antigen 
                 611684 
                   
                 protein; 
               
               
                   
                   
                 recognized by T 
                   
                   
                 tumor-rejection 
               
               
                   
                   
                 cells 3 
                   
                   
                 antigen; induces HLA- 
               
               
                   
                   
                   
                   
                   
                 A24-restricted and 
               
               
                   
                   
                   
                   
                   
                 tumor-specific 
               
               
                   
                   
                   
                   
                   
                 cytotoxic T 
               
               
                   
                   
                   
                   
                   
                 lymphocytes in cancer 
               
               
                 242842_at 
                 −14.51 
                 Transcribed locus 
                 — 
                 — 
               
               
                 242868_at 
                 −15.34 
                 Endothelial PAS 
                 EPAS1 
                 angiogenesis /// 
               
               
                   
                   
                 domain protein 1 
                 603349 
                 response to hypoxia /// 
               
               
                   
                   
                   
                   
                 regulation 
               
               
                   
                   
                   
                   
                 of transcription, DNA- 
               
               
                   
                   
                   
                   
                 dependent /// 
               
               
                   
                   
                   
                   
                 transcription 
               
               
                   
                   
                   
                   
                 from RNA polymerase 
               
               
                   
                   
                   
                   
                 II promoter /// signal 
               
               
                   
                   
                   
                   
                 transduction /// cell 
               
               
                   
                   
                   
                   
                 differentiation /// 
               
               
                   
                   
                   
                   
                 transcription /// signal 
               
               
                   
                   
                   
                   
                 transduction /// 
               
               
                   
                   
                   
                   
                 development /// 
               
               
                   
                   
                   
                   
                 regulation of 
               
               
                   
                   
                   
                   
                 transcription 
               
               
                 206859_s_at 
                 −15.64 
                 Progestagen- 
                 PAEP 
                 transport /// 
                 genital tract, 
               
               
                   
                   
                 associated 
                 173310 
                 development 
                 secretory endometrium 
               
               
                   
                   
                 endometrial protein 
                   
                   
                 and decidua; 
               
               
                   
                   
                 (placental protein 
                   
                   
                 inhibits E-selectin- 
               
               
                   
                   
                 14, pregnancy- 
                   
                   
                 mediated cell adhesion; 
               
               
                   
                   
                 associated 
                   
                   
                 neovascularization 
               
               
                   
                   
                 endometrial alpha- 
               
               
                   
                   
                 2-globulin, alpha 
               
               
                   
                   
                 uterine protein) 
               
               
                 204580_at 
                 −17.18 
                 Matrix 
                 MMP12 
                 peptidoglycan 
                 macrophages, ECM; 
               
               
                   
                   
                 metallopeptidase 12 
                 601046 
                 metabolism /// 
                 Degrades elastin, tissue 
               
               
                   
                   
                 (macrophage 
                   
                 proteolysis /// 
                 remodeling and repair 
               
               
                   
                   
                 elastase) 
                   
                 cell motility /// 
                 during development 
               
               
                   
                   
                   
                   
                 proteolysis 
                 and inflammation 
               
               
                   
                   
                   
                   
                   
                 (1 in vitro) 
               
               
                 207509_s_at 
                 −18.87 
                 Leukocyte- 
                 LAIR2 
                 — 
                 homologous with 
               
               
                   
                   
                 associated 
                 602993 
                   
                 LAIR1 on NK cells, T 
               
               
                   
                   
                 immunoglobulin- 
                   
                   
                 cells, B cells, 
               
               
                   
                   
                 like receptor 2 
                   
                   
                 macrophages, and 
               
               
                   
                   
                   
                   
                   
                 dendritic cells; 
               
               
                   
                   
                   
                   
                   
                 secreted Ig-like 
               
               
                   
                   
                   
                   
                   
                 receptor 
               
               
                   
               
               
                 Table downloaded from Affymetrix. 
               
             
          
         
       
     
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