Abstract:
The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus there is a constant demand for formulations that efficiently model the hair fiber without damage. 
     Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.

Description:
TECHNICAL DOMAIN 
       [0001]    The current application corresponds to a composition that comprises at least one peptide, based on keratin and keratin associated proteins, containing 2 to 5 cysteines with the purpose of treatment and cosmetics of animal hair, in preference human hair. 
       PRIOR ART 
       [0002]    Human hair has a significant social role in most of the various world cultures, particularly for female population. Thus, there is a constant desire to improve and change hair characteristics, such as its natural texture. There are several differences in hair characteristics between different human ethnicities, as well as between individuals of the same ethnicity, such as length, thickness, color and texture. 
         [0003]    Hair is composed of approximately 65% to 95% protein. The remaining constituents include water, lipids, pigments and trace elements. The majority of the proteins present in human hair correspond to keratin and keratin-associated proteins. 
         [0004]    Human hair fibers structure consists of cuticle, cortex and medulla. The cuticle constitutes about 15% by weight of the hair and consists of overlapping layers of cells, similar to a system of scales, with high content of cysteine. It provides a protective character to the hair fiber. The cortex is the middle region of the hair being responsible for the strength, elasticity and hair color. It is composed of several cell types and represents about 80% of the weight of the hair. The medulla corresponds to a central beam of cells, and is absent in some hairs. 
         [0005]    Keratins and mainly keratin-associated proteins have high sulfur content, present in the cysteine amino acid. The presence of sulfur is essential to the hair structure, as it allows the formation of disulfide bonds between amino acids of the polypeptide chains, due to oxidation of cysteine. The existence of these bonds is largely responsible for the structure and texture of the hair. 
         [0006]    There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals such as sodium hydroxide, potassium hydroxide, lithium hydroxide, guanidine hydroxide, ammonium thioglycolate or sodium sulfate. These methods can damage the scalp and the hair fiber, leading to its weakening and reducing its tensile strength. Formaldehyde, an extremely toxic chemical, is also used in hair straightening products. Other hair treatments that do not involve so much damage to the hair and the consumer are usually very expensive, time-consuming and/or have low efficacy. Thus there is a constant demand for formulations that efficiently model the hair fiber without damage. 
         [0007]    Peptides, proteins, amino acids and its derivatives have also been used in compositions for personal care products, namely hair conditioning and strengthening. For example, the document WO 00/23039 discloses a composition for hair treatment containing intermediate filament proteins, namely artificial keratin. The document EP 0488242 discloses a hair treating agent containing 3% to 10% by weight of cysteine and salts thereof, a polyhydric alcohol or a saccharide containing four to twenty carbon atoms, three or more hydroxyl groups in the molecule and no aldehyde or ketone group. 
         [0008]    The current invention is distinguished by the use of peptides, while the other applications refer the use of, respectively, proteins and amino acids in isolation and together with other types of compounds. The peptides in this innovation peptide can penetrate into the human hair in order to improve hair fiber resistance. 
         [0009]    The document WO 00/51556 discloses a hair treatment composition that contains four or more discrete amino acids selected from histidine, lysine, methionine, tyrosine, tryptophan or cysteine. This document describes peptides without referring sequences and providing a composition essentially based on histidine, lysine, methionine, tyrosine, tryptophan or cysteine. 
         [0010]    The document PT 103484 describes a formulation for cosmetic applications that uses hydrophobic binding domains and/or carbohydrates, in order to enhance its properties and to repair hair damage. The binding domains used are hydrolyzed milk protein, a model of human surfactant protein as well as biologically active and synthetic peptides. The current invention is distinguished by the innovative use of synthetic peptide sequences analogous to keratin proteins instead of surfactant proteins. Furthermore, it does not rely on hydrophobic binding domains and/or carbohydrates, but in other interactions, namely disulfide bonds. 
         [0011]    Enzymes have also been used as activating agents for hair treatment, such as in the document WO 00/64405. The document WO 2012/13593 discloses a cosmetic kit for hair conformational change that acts specifically in the disulfide bonds of the hair keratin, through enzyme activating agents and proteolytic enzymes. 
         [0012]    As described in the last document there are hair treatments that include actions at the level of the hair disulfide bonds. Below we highlight some examples. 
         [0013]    The document WO 97/11672 reports a method for permanent hair processing using tris(2-carboxyethyl)phosphine (TCEP), and other water-soluble tertiary phosphines to break disulfide bonds, whose reaction occurs in acidic environment. The document U.S. Pat. No. 5,635,170 discloses a composition for permanent shaping of hair based on a keratin reducing agent, which contains N-glycyl-L-cysteine and/or L-cysteinyl-glycine. The pH range of this composition is 6.5 to 9.0. The document WO 2008/081348 refers a method and composition for permanent modulation of hair, through the use of 1% to 30% of N-alkyl-2-mercapto acetamide as a keratin reducing agent. It also contains at least one cationic surfactant for permanently shaping hair and the resulting process. The document WO 2006/001536 describes an agent for permanent hair processing that contains a derivative of mercaptocarboxylic acid, which allows processing and reduction of hair keratin in the acidic and neutral range of the pH. The document US 2010/0272666 discloses a hair cosmetic composition for hair treatment, containing 5 to 50 amino acids, without containing cysteine or its derivatives. Thus, this invention is distinguished by the existence of specific amino acid sequences, which contain cysteine, allowing the formation of disulfide bonds that stabilize and protect the hair fiber. 
         [0014]    In a previous article by Fernandes et al. (Fernandes, Lima, Loureiro, Gomes, &amp; Cavaco-Paulo, 2012), it is performed the toxicology evaluation of a peptide sequence for hair care use, containing 13 amino acids with two cysteines in its composition. However, in this article it is not mentioned or suggested that the percentage of cysteine in a peptide sequence may have some effect on the resistance of the hair. Also, in the present innovation, the number of amino acids of each peptide sequence is 6 to 12. 
       General Description 
       [0015]    Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and that does not present the drawbacks found in the state of the art. 
         [0016]    The compositions described in the current invention, after prolonged use, provide hair with soft, shiny, undamaged texture and with the desired features. The peptide compositions with a specific number of amino acids and cysteines act synergically providing resistance to strength, toughness and elasticity to the hair. Therefore, the compositions of the current invention are particularly relevant for hair treatment, hair dying, hair perms, etc. 
         [0017]    The present application describes a peptide composition for hair treatment, in particular human or animal hair, which comprises at least one peptide with 6-12 amino acids length (namely 6, 7, 8, 9, 10, 11, 12 amino acids), where 2-5 of those amino acids correspond to cysteine, preferably 2, 3, 4 or 5 of those amino acids are cysteines and dermatologically suitable excipients, which penetrates the hair, increasing it resistance and reducing it breakage. 
         [0018]    In the embodiment, for improved results, the peptide (or peptides) of the peptide composition for hair care can comprise 10-11 amino acids. 
         [0019]    In the embodiment of the peptide composition for hair care treatment, the referred peptides can also contain a percentage of hydrophobic amino acids, not higher than 60%, and preferably less than 41% for better results. Preferably, the composition can also comprise at least one hydrophobic amino acid selected from the following list: phenylalanine, alanine, leucine, methionine, isoleucine, tryptophan, proline, valine or their mixtures. 
         [0020]    In yet another embodiment, the amount of cysteine of the peptide composition for hair treatment may vary from 10% to 50% of the total of amino acids of the peptide sequence, preferably 20-30%, and even more preferably 25%. 
         [0021]    In an embodiment of the composition, with better results of the peptide (or peptides) of the peptide composition for hair treatment, the sequence of peptide(s) can comprise at least one sequence of the following list with a with a degree of homology greater than or equal to 90%: SEQ. ID NO:1-SEQ. ID NO:1239, preferably with a degree of homology greater than or equal to 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100%. 
         [0022]    In an embodiment, improved results for the peptide (or peptides) of the peptide composition for hair treatment can comprise at least one of the sequences of the following list with a degree of homology equal or greater than 90%: SEQ. ID NO:5, SEQ. ID NO:75; SEQ. ID NO:94; SEQ. ID NO: 409; SEQ. ID NO:411; SEQ. ID NO:412; SEQ ID. NO:432; SEQ. ID NO:618; SEQ. ID NO:717; SEQ. ID NO:951; SEQ. ID NO:1088; SEQ. ID NO:1131; SEQ. ID NO:1149, preferably with a degree of homology equal or greater than 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100%. 
         [0023]    In other embodiment, the concentration of the peptide of the peptide composition for hair treatment can vary between 0.001%-20% (w/w), preferably 0.01-5% (w/w). 
         [0024]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one excipient, selected from the following list: surfactants, emulsifiers, preservatives, thickeners, organic polymers, humectants, silicones, oils, fragrances, vitamins, buffers. 
         [0025]    In another embodiment, the peptide composition for hair treatment can comprise at least one anionic surfactant selected from the following list: alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylenesulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or any mixture thereof. 
         [0026]    In an embodiment, the peptide composition for hair treatment can comprise at least one amphoteric surfactant selected from the following list: cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or any mixture thereof. 
         [0027]    In other embodiment, the peptide composition for hair treatment can comprise at least one cationic surfactant selected from the following list: quaternary ammonium compounds, behentrimonium chloride, behentrimonium methosulfate, benzalkonium chloride, betrimonium chloride, binnamidopropyltrimonium chloride, cocotrimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, dihydrogenated tallow dimethylammonium chloride, hydrogenated Palm trimethylammonium chloride, laurtrimonium chloride, quaternium-15, quaternium-18 bentonite, quaternium-22 hectonite, stearalkonium chloride, tallowtrimonium chloride, tricetyldimonium chloride, or any mixture thereof. 
         [0028]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one non-ionic surfactant selected from the following list: decyl glucoside, laureth-10 (lauryl ether 10), laureth-23, Laureth-4, PEG-10 sorbitan laurate, polysorbate-(20, 21, 40, 60, 61, 65, 80, 81), PPG-1 trideceth-6, sorbitol, steareth-(2, 10, 15, 20), C11-21 pareth-(3-30), C12-20 acid PEG-8 ester, or their mixtures. 
         [0029]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one emulsifier selected from the following list: caprylic/capric/diglyceryl succinate, C10-15 pareth-(2,4,6,8) phosphate, C14-16 glycol palmitate, C18-20 glycol isostearate, ceteareth-(4-60), cocamidopropyl lauryl ether, deceth-(3-10), DIPA-hydrogenated cocoate, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxyisostea rate, dipentaerythrityl hexacaprate/caprylate, dodoxynol-(5,6,7,9,12), nonoxynol-(1-35), octoxynol-(1-70), Octyldodeceth-(2,5,16,20,25), Palm kernel glycerides, or any mixture thereof. 
         [0030]    In other embodiment, the peptide composition for hair treatment can comprise at least one preservative selected from the following list: butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, or any mixture thereof. 
         [0031]    In other embodiment, the peptide composition for hair treatment can comprise at least one thickner selected from the following list: aluminum stearates/isostearates/myristates/laurates/palmitates, glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, hydrogenated castor PEG-8 esters, PEG-150 distearate, or any mixture thereof. 
         [0032]    In other embodiment, the peptide composition for hair treatment can comprise at least one natural polymer derived selected from the following list: carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, or any mixture thereof. 
         [0033]    In other embodiment, the peptide composition for hair treatment can comprise at least one humectant selected from the following list: 1,2,6 hexanetriol, dipropylene glycol, glycerin, hexylene glycol, panthenol, phytantriol, propylene glycol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, hexanediol beeswax, hexanetriol beeswax, hydrolyzed elastin, hydrolyzed collagen, hydrolyzed silk, hydrolyzed keratin, erythritol, capryl glycol, isoceteth-(3-10, 20, 30), isolaureth-(3-10, 20, 30), laneth-(5-50), laureth-(1-30), steareth-(4-20), trideceth-(5-50), or any mixture thereof. 
         [0034]    In other embodiment, the peptide composition for hair treatment can comprise at least one cationic polymer selected from the following list: polyquaternium-10, polyquaternium-7, polyquaternium-11m guar hydroxypropyltrimonium chloride, or any mixture thereof. 
         [0035]    In other embodiment, the peptide composition for hair treatment can comprise at least one silicone selected from the following list: amodimethicone, amodimethicone, trideceth-12, cetrimonium, chloride mixture, behenoxy, dimethicone sparingly, cetearyl methicone, cetyl dimethicone, cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, stearoxy dimethicone sparingly, stearyl dimethicone, trimethylsilylamodimethicone, lauryl methicone copolyol, or any mixture thereof. 
         [0036]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one organic oil selected from the following list: mineral oil, paraffin, petrolatum, or any mixture thereof. 
         [0037]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one protein selected from the following list: cocodimonium hydroxypropyl hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed wheat protein, keratin, potassium cocoyl hydrolyzed collagen, TEA-cocoyl hydrolyzed collagen, TEA-cocoyl hydrolyzed soy protein, or any mixture thereof. 
         [0038]    In other embodiment, the peptide composition for hair treatment can comprise at least one vitamin selected from the following list: retinol, retinyl palmitate tocopherol acetate, or any mixture thereof. 
         [0039]    In other embodiment, the peptide composition for hair treatment can comprise at least one ester emollient selected from the following list: butyl myristate, butyl stearate, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl octanoate, cetyl stearate, cetearyl stearate, decyl oleate, dimethyl lauramine isostearate, glyceryl stearate, glyceryl adipate, glyceryl arachidate, glyceryl arachidonate, glyceryl behenate, glyceryl caprate, glyceryl caprylate, glyceryl caprylate/caprate, glyceryl citrate/lactate/linoleate/oleate, glyceryl cocoate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilaurate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl diricinoleate, glyceryl distearate, glyceryl erucate, glycol stearate, isocetyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate/dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, Sorbitan laurate, sorbitan tristearate, stearyl stearate, tocopheryl linoleate, or any mixture thereof. 
         [0040]    In other embodiment, the peptide composition for hair treatment can comprise at least one alkanolamide selected from the following list: acetamide MEA, cocamide DEA, cocamide MEA, lactamide MEA, lauramide DEA, lauramide DEA, propylene glycol, lauramide MEA, lecithinamide DEA, linoleamide DEA, linoleamide MEA, linoleamide MIPA, myristamide DEA, myristamide MEA, myristamide MIPA, oleamide DEA, oleamide DEA, oleamide MEA, oleamide MIPA, soyamide DEA, stearamide MEA, or any mixture thereof. 
         [0041]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one amine selected from the following list: behentamidopropyl dimethylamine, cocamidopropyl dimethylamine, isostearamidopropyl dimethylamine, lauramidopropyl dimethylamine, myristamidopropyl dimethylamine, oleamidopropyl dimethylamine, palmitamidopropyl dimethylamine, stearamidopropyl dimethylamine, tallamidopropyl dimethylamine, or any mixture thereof. 
         [0042]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one pH adjuster selected from the following list: ascorbic acid, citric acid, sodium hydroxide, triethanolamine, or any mixture thereof. 
         [0043]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one salt selected from the following list: calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or any mixture thereof. 
         [0044]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one aliphatic alcohol selected from the following list: behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, or any mixture thereof. 
         [0045]    In another embodiment, the peptide composition for hair treatment can comprise at least one UV filter/sunscreen selected from the following list: benzophenone-(2, 3, 4, 5, 6, 7, 8, 9, or 10), benzophenone-4, benzyl salicylate, benzylidene camphor sulfonic acid, bornelone, ethyl cinnamate, ethylhexyl methoxycinnamate (octyl methoxycinnamate), octoxynol-40, octoxynol-20, octyl methoxycinnamate, octyl salicylate, oxybenzone, phenyl ketone, PEG-25 PABA, polyacrylamidomethyl benzylidene camphor, or any mixture thereof. 
         [0046]    In other embodiment, the peptide composition for hair treatment can comprise at least one natural oil selected from the following list: coconut oil, jojoba oil, olive oil, palm Oil, safflower oil, sesame seed oil, shea butter, sweet almond oil, wheat germ oil, or any mixture thereof. 
         [0047]    In yet other embodiment, the peptide composition for hair treatment can comprise at least one amine oxide selected from the following list: cocamine oxide, lauramine oxide, or any mixture thereof. 
         [0048]    In other embodiment, the peptide composition for hair treatment can comprise at least one chelate selected from the following list: diiospropyl oxalate, disodium EDTA, disodium EDTA-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, dodium oxalate, TEA-EDTA, tetrasodium EDTA, trisodium EDTA, trisodium HEDTA, or any mixture thereof. 
         [0049]    In other embodiment, the peptide composition for hair treatment can comprise at least one fatty acid selected from the following list: arichidonic acid, capric acid, coconut fatty acid, lauric acid, linoleic acid, linolenic acid, myristic acid, palmitic acid, pantothenic acid, stearic acid, caproic acid, capryleth-(4, 6, 9) carboxylic acid, isostearic acid, or any mixture thereof. 
         [0050]    In other embodiment, the peptide composition for hair treatment can comprise at least one agent antimicrobial/antibacterial selected from the following list: glyoxal, triclosan, or any mixture thereof. 
         [0051]    In other embodiment, the peptide composition for hair treatment can comprise at least one PEG-modified material selected from the following list: PEG-150 pentaerythirtyl tetrastearate, PEG-(−2, −3, −4, −6, −8, −12, −20, −32, −50, −150, −175) distearate, PEG-10 castor oil, PEG-10 cocamine, PEG-10 cocoate, PEG-10 coconut oil esters, PEG-10 glyceryl oleate, PEG-10 glyceryl pibsa tallate, PEG-10 glyceryl stearate, PEG-10 hydrogenated lanolin, PEG-10 hydrogenated tallow amine, PEG-10 isolauryl thioether, PEG-10 isostearate, PEG-10 lanolate, PEG-10 lanolin, PEG-10 laurate, PEG-10 oleate, PEG-10 olive glycerides, PEG-10 polyglyceryl-2 laurate, PEG-10 propylene glycol, PEG-10 sorbitan laurate, PEG-10 soya sterol, PEG-10 soyamine, PEG-10 stearamine, PEG-10 stearate, PEG-10 stearyl benzonium chloride, PEG-10 tallate, PEG-10 tallow aminopropylamine, PEG-100, PEG-100 castor oil, PEG-100 hydrogenated castor oil, PEG-100 lanolin, PEG-100 stearate, PEG-40 hydrogenated castor Oil, PEG-60, PEG-55 propylene glycol distearate, or any mixture thereof. 
         [0052]    In other embodiment, the peptide composition for hair treatment can comprise at least one polymer selected from the following list: carbomer, dodecanedioic acid/cetearyl alcohol/glycol copolymer, hydrogenated C6-14 olefin polymers, hydrogenated ethylene/propylene/styrene copolymer: polyacrylic acid, polymethyl methacrylate: polymer, polyvinyl acetate, polyvinyl alcohol, PPG, PPG-25-laureth-25, PPG-5 pentaerithrityl ether, PPG-75-PEG-300-hexylene glycol, polyvinylpyrrolidone, PVP/VA (polyvinylpyrrolidone/vinyl acetate copolymer), sodium carbomer, TEA-carbomer, poloxamer (100-407), poloxamine, polyacrylamidomethylpropane sulfonic acid, polyethylene terephthalate, or any mixture thereof. 
         [0053]    In other embodiment, the peptide composition for hair treatment can comprise at least one antistatic agent selected from the following list: apricotamidopropyl ethyldimonium ethosulfate, apricotamidopropyl ethyldimonium lactate, cocamidopropyl ethyldimonium ethosulfate, cocamidopropyl ethyldimonium lactate, lauramidopropyl ethyldimonium ethosulfate, lauramidopropyl ethyldimonium lactate, linoleamidopropyl ethyldimonium ethosulfate, linoleamidopropyl ethyldimonium lactate, myristamidopropyl ethyldimonium ethosulfate, myristamidopropyl ethyldimonium lactate, oleamidopropyl ethyldimonium ethosulfate, oleamidopropyl ethyldimonium lactate, stearamidopropyl ethyldimonium ethosulfate, stearamidopropyl ethyldimonium lactate, or any mixture thereof. 
         [0054]    In other embodiment, the peptide composition for hair treatment can comprise at least one alcohol selected from the following list: SD alcohol 40, witch hazel, isopropanol, or any mixture thereof. 
         [0055]    In yet other embodiment, the peptide composition for hair treatment can comprise fragrances, oils or any mixture thereof. 
         [0056]    In other embodiment, the peptide composition for hair treatment can be used in medicine, veterinary and/or for cosmetics, preferably for the treatment of hair, mainly for animal or human, particularly for treating diseases of the scalp, particularly scalp irritation, alopecia areata, lichen planus, folliculitis keloid of the neck, trichorrhexis nodosa, tricodistrophy, pili torti, tricorrexis invaginata, moniletrix, uncombable hair syndrome. 
         [0057]    In other embodiment, the composition may comprise a dye agent linked to the N or C-terminal of the referred peptides. 
         [0058]    In yet other embodiment is the use of the described composition for hair coloring. 
         [0059]    Other aspect of the embodiment is the use of the described composition as a hair strengthener or as fixer of perms and/or curly hairs. 
         [0060]    It is also described in this application shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask comprising the composition presented in this application. 
         [0061]    The present application discloses a composition for hair treatment that comprise, in whole or in part, one or more peptide sequences of 6 to 12 amino acid residues based on keratin and keratin-associated proteins having 2 to 5 cysteine residues, preferably having 3 to 5 residues of cysteine, for treatment and cosmetics of the hair, preferably human hair, chemically pre-treated or not. Thus the presence of cysteine in the peptide sequence (higher than 10%, preferably more than 15%) in combination with a percentage of hydrophobic amino acids ensures that the peptides can have a lasting fixation in the hair, improving the human hair properties such as elasticity and strength. 
         [0062]    Surprisingly, the described peptide compositions in which the peptide(s) comprising 2 to 5 cysteines allow penetration of the peptide(s) and enhance the properties of hair, preferably 3-5 cysteines. Thus, described peptide(s) containing 2-5 cysteine in order to allow hair penetration and enrichment of the hair properties, such as elasticity, resistance, reduce eventual hair damage, as well as improve and change hair characteristics. 
         [0063]    The peptide compositions described in the present application surprisingly enrich and improve the properties and characteristics of the hair, such as elasticity, strength and appearance, repairing damaged keratinous fiber. Therefore, formulation&#39;s high cysteine content is used to improve and/or change its characteristics, such as hair curl or uncurl. The sequence of peptides can have also preferably a percentage of hydrophobic amino acids not exceeding 60%, improving even further the results. Examples of hydrophobic amino acids are phenylalanine, alanine, leucine, methionine, isoleucine, tryptophan, proline, valine, and others. 
         [0064]    In the context of the present description, the peptide composition can also be applied to the hair and in particular to the human hair as, but not limited to, aqueous solution or conventional shampoo or conditioner. It can also be used as a lotion, foam, aerosol, gel, mask, and application formulation with or without subsequent rinsing. 
         [0065]    The concentration of peptide to be used depends on several features such as the condition of the hair, the origin and the formulation of the hair care product. 
     
    
     DETAILED DESCRIPTION 
       [0066]    It should be understood that the detailed description and specific examples are indicative of preferred embodiments of the invention and are provided to be illustrative only. This patent is not limited to those mentioned applications. 
         [0067]    The present application describes a composition for hair treatment that comprises different peptides, which are based in the structure of keratin and keratin associated proteins. 
         [0068]    The compositions described in the present application allow surprisingly the dermo-cosmetic treatment of animal hair, including human hair, chemically pre-treated or not. The composition described in the present invention, through the use of specific peptides, allows the preparation of keratinous fiber damages, due to the high binding capacity of the keratin peptides, including through disulfide bridges. 
         [0069]    The described compositions improve the properties and characteristics of the hair, such as elasticity, resistance and appearance, repairing putative damages of the hair. 
         [0070]    The peptides here defined are peptide sequences which bind with a certain affinity to the hair. The peptides used in this invention are composed by 6 to 12 amino acids, and are constituted by a minimum of 2 and a maximum of 5 cysteines, preferably 3-5 cysteines. 
         [0071]    The peptide composition for hair treatment described allows a resistance increase due to the presence of the cysteine-rich peptide, which leads to the resistance of the hair even after several rinsing. 
         [0072]    Every peptide can be used together or separately, as well as all or part of the peptide sequence in the hair composition. Each peptide sequence contains amino acids with sulfur, specifically cysteine, which interacts with the hair and allows the formation of intermolecular cross-linking, stabilizing the keratinous fiber. 
         [0073]    The peptide composition described uses a high content on cysteine in order to enrich the hair properties, such as improve elasticity and resistance, reduce putative damage of the hair, improve and/or change hair characteristics. Regarding the interaction with the keratinous fibers, the cysteine is 10% to 50% of the total amount of amino acids of the peptide sequence. Additionally, the number of amino acids of the peptide sequence is preferable from 6 to 12. 
         [0074]    The peptides can be used separately or in combination of two or more peptides. The concentration of the peptide to be used depends on several characteristics, such as hair condition, origin and the formulation of the product for hair treatment. The content of the hair composition of the present invention is as example 1-0.001% (w/w) in mass. 
         [0075]    The peptides of the present invention can be prepared by conventional methods of peptide synthesis, well known in the state of the art. 
         [0076]    Additionally many companies provide customized services for peptide synthesis. 
         [0077]    An embodiment of the current invention describes peptides that link to the hair, and which sequence of amino acids includes cysteines where the sequence is selected from the group between the sequences ID NO:1 to sequence ID NO:1239. 
         [0078]    The sequence of the 1239 peptides referred is listed in the table of the FIG. 1. 
         [0079]    As example of hair, it was used virgin human hair tresses, acquired from the International Hair Importers and Products, Inc. (New York). The term virgin hair is applied to all the hair that was never subject or was at least 10 years without making any chemical treatment. Several different hair samples such as African, Asian and Caucasian hair are commercially available in several companies, such as the company mentioned above. Optionally, the hair samples can be treated, for example, using hydrogen peroxide to bleach the hair, needed for techniques such as hair dying. 
         [0080]    In the context of this invention, the peptides can be applied to the hair, such as the human hair in the form of, but not limited to, aqueous or conventional preparation of shampoo or conditioner. It can also be in the form of lotion, foam, spray, gel, mask, formulation applied with or without subsequent rinsing. 
         [0081]    This invention can be prepared by peptide coupling with an agent of these preparations directly or via a spacer. 
         [0082]    This coupling interaction can be performed by covalent or non-covalent bonds, such as hydrogen bond, electrostatic interactions, hydrophobic interactions or van der Waals interactions. The spacer can be used to separate the peptide from the preparation agent, ensuring that the agent does not interfere with the peptide linkage to the hair. 
         [0083]    The present invention can be understood more clearly and accurately by reading the following examples, which are indicative of preferred embodiments of the invention. They are provided for illustration in greater detail of the present invention, without introducing any limitation and without being limited to those applications. 
       EXAMPLES OF APPLICATIONS 
       [0084]    The examples that are within the scope of the claims represent different embodiments of the invention; all other examples are comparative examples. 
       Example 1 
       [0085]    The present application treats human hair through several commercial formulations with and without the use of the peptides from the sequence ID NO: 5. As The hair was supplied from International Hair Importers and Products, Inc. (New York). 
         [0086]    The tests were performed with in human hair after 8 treatments of bleaching, at 50° C. in 0.1 M Na 2 CO 3 /NaHCO 3  buffer, at pH=9, 10% H 2 O 2 , for 1 hour. 
         [0087]    Several formulations were tested:
       hair serum with 15% PG;   hair mask.       
 
         [0090]    The mask used in this application was a basic commercial formulation with water, denaturing alcohol, propylene glycol, ether dicaprylic, cetylstearyl alcohol, behentrimonium chloride, cetyl ester, polysorbate 20, hydrolyzed wheat protein, hydrolyzed wheat starch, benzyl alcohol and fragrance. 
         [0091]    The hair serum used in this application was a basic commercial formulation with water, denaturing alcohol, propylene glycol, polysorbate 20, hydrolyzed wheat protein, hydrolyzed wheat starch, crosslinked polymer alkyl acrylate/C10-30, triethanolamine, benzyl alcohol, fragrance. 
         [0092]    Each of the formulations was tested with and without the peptide sequence ID NO:5, which contains in the sequence 15% of cysteine. The formulations containing the peptide SEQ ID NO:5 had a concentration of peptide of 0.1 mg/mL, in a ratio 1:1 (v/v). 
         [0093]    To demonstrate the effect was also tested:
       a peptide whose sequence does not contain cysteine, with approximately 41% hydrophobic amino acids;   a peptide which contains in it sequence 8% cysteine, with approximately 58% hydrophobic amino acids.       
 
         [0096]    The hair mask was applied to the hair after 8 bleaching treatments, being left to act for 15 minutes, mimicking the procedure indicated in commercial masks. Posteriorly, the hair was washed. The serum was applied to the hair after 8 bleaching treatments, being left to act for 1 hour at 37° C. Posteriorly, the hair was not washed, as in typical commercial procedures the serum should be applied in dry hair. The hair was also tested after 5 applications. 
         [0097]    The peptide from the sequence ID NO: 5 was able to penetrate in the hair fiber for all the formulations. 
         [0098]    After the treatment, mechanical tests were performed, using a cell with 2.5 N maximum load and a deformation rate of 1.5 mm/min. Each hair was individually mounted in the tensile jig by means of a paper template with a fixed gauge length of 20 mm. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Young modulus of virgin hair without treatments 
               
               
                 and after 8 times bleaching treatments. 
               
             
          
           
               
                   
                 Hair type 
                 Young modulus (MPa) 
               
               
                   
                   
               
               
                   
                 Virgin hair 
                 6579 
               
               
                   
                 Hair after 8 time bleaching 
                 5294 
               
               
                   
                 Serum(with a 15% cysteine and 50% 
                 7149 
               
               
                   
                 hydrophobic amino acids peptide) 
               
               
                   
                 Serum for comparison(with a 41% 
                 6180 
               
               
                   
                 hydrophobic amino acid without 
               
               
                   
                 cysteine peptide) 
               
               
                   
                 Serum for comparison 
                 6456 
               
               
                   
                 (with a 8% cysteine and 58% 
               
               
                   
                 hydrophobic amino acid peptide) 
               
               
                   
                 Serum for comparison (without peptide) 
                 6034 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Young modulus for different types of hair treatment. The peptide 
               
               
                 in these treatments is the peptide from sequence ID NO: 5. 
               
             
          
           
               
                   
                 Young modulus 
                 Young modulus 
               
               
                   
                 after 1 
                 after 5 
               
               
                 Type of treatment 
                 application (MPa) 
                 applications (MPa) 
               
               
                   
               
               
                 Serum (with a 15% cysteine 
                 7149 
                 7318 
               
               
                 and 50% hydrophobic amino 
               
               
                 acid peptide) 
               
               
                 Serum for comparison 
                 6034 
                 6112 
               
               
                 (without peptide) 
               
               
                 Mask (with a 15% cysteine 
                 6175 
                 7075 
               
               
                 and 50% hydrophobic amino 
               
               
                 acid peptide) 
               
               
                 Mask for comparison(without 
                 5514 
                 5685 
               
               
                 peptide) 
               
               
                   
               
             
          
         
       
     
         [0099]    The formulations which contain the sequence ID NO:5 induce an increase in mechanical resistance of the damaged hair. After 5 applications, the hair treated with the sequence ID NO: 5 maintain the high resistance, having a higher increase in the resistance than without the peptide. 
       Example 2 
       [0100]    This example discloses the treatment of human hair with peptides containing cysteine, and in this case the peptide containing the sequence ID NO: 409, based in the assumption that small peptides are able to penetrate in the hair fiber cuticle. 
         [0101]    The hair was supplied from International Hair Importers and Products, Inc. (New York). Hair fibers were pre-treated by bleaching. The formulation was tested in different hair types:
       virgin hair washed, with the cuticle intact and absence of chemical damages;   hair after 8 bleaching treatments, at 50° C. in 0.1 M Na 2 CO 3 /NaHCO 3  buffer, at pH=9, 10% H 2 O 2 , for 1 hour.       
 
         [0104]    The incorporation of the peptides was performed by direct application in the hair surface. The mechanical resistance tests were performed after the treatment of the hair with the peptide. 
         [0105]    The measurements of mechanical resistance were performed using a cell with 2.5 N maximum load and a deformation rate of 1.5 mm/min. Each hair was individually mounted in the tensile jig by means of a paper template with a fixed gauge length of 20 mm. 
         [0106]    As for the results obtained for the mechanical test showed that compared to the control, i.e., virgin hair without bleaching or peptide treatment (Young modulus: 4142±590 MPa), bleaching reduced the Young modulus (2478±567 MPa), while the treatment with the peptide sequence ID NO: 409 after bleaching increased the Young modulus to higher valued than the virgin hair with no treatment (5649±1022 MPa). 
       Example 3 
       [0107]    This example discloses the treatment of human hair with a composition comprising peptides. In this example, the peptide with the sequence ID NO: 412 was tested. The hair was supplied from International Hair Importers and Products, Inc. (New York). 
         [0108]    The formulation was tested in different hair types:
       virgin hair washed, with the cuticle intact and absence of chemical damages;   hair after reduction treatment, at 37° C. in phosphate buffer at pH=8, with 3M GndHCl and 0.05M DTT for 2 hours.       
 
         [0111]    For the treatment with the peptide SEQ ID NO: 412, concentrations of 0.01% (w/w) were used. 
         [0112]    The average of the Young modulus for relaxed hair is 3002 MPa, while for relaxed hair fiber after peptide treatment at 0.01% is 4190 MPa. The Young modulus value for virgin hair without treatment is 5214 MPa. 
         [0113]    In the maximum load test, for the relaxed hair fiber, the maximum of resistance were 96 MPa, while for the hair fiber relaxed after peptide treatment 126 MPa and for the virgin hair with no treatment 203 MPa. 
         [0114]    Regarding hair stretching, the relaxed hair has an average of 51%, while after treatment with the peptide sequence ID NO: 412, has a stretching of 72%. For virgin hair, the average of hair stretching is 58%. 
         [0115]    Therefore, it is evident that the peptides are capable to prevent the hair surface degradation and consequently, the hair treated with these peptides has a longer life span. 
       Example 4 
       [0116]    In order to assess the interactions between the keratin and some peptides, a keratin solution was prepared. This procedure was performed by immersing African hair, acquired from the International Hair Importers and Products, Inc. (New York), in a solution containing 8 M urea, 0.2 M sodium dodecyl sulfate and 0.5 M sodium bisulfite. The mixture was heated to 50° C. for 24 h in a shaker bath. The solution was dialyzed for several days against double-distilled water. The keratin solution was then concentrated using AMICON with a 3 kDa cut-off. The keratin was then conjugated with Alexa Fluor 647 carboxylic acid, succinimidyl ester in DMSO anhydrous 5%. 
         [0117]    The reaction was incubated for 1 h30 min at room temperature and in the dark. The Alexa Fluor 647 that did not link to the keratin solution was separated by centrifugation in AMICON with a 3 kDa cut-off for 1 h at 25° C. and 5000×g. 
         [0118]    The keratin was then diluted to 10 g/mL in blocking buffer (3% BSA in tris-buffered saline (TBS) with 0.05% Tween 20). The peptides tested were SEQ. ID NO:179, SEQ. ID NO:75, SEQ. ID NO:432, SEQ. ID NO:951, SEQ. ID NO:1108, SEQ. ID NO:1131 and a peptide containing 13 amino acids, including 2 cysteines (X 3 CX 5 CX 3 ), where X represents one of known amino acid residues, with the exception of cysteine residue that is represented by the letter C. This peptide is similar to the one tested in Fernandes et al. (Fernandes, Lima, Loureiro, Gomes, &amp; Cavaco-Paulo, 2012). 
         [0119]    Several peptides in a concentration of 15 fmol/mm 2 , were attached to a glass through a hydrophilic linked moiety, and were then incubated with the keratin, marked with Alexa Fluor 647, for 2 hours at 37° C. 
         [0120]    After incubation, the glasses were rinsed in successive washing solutions: TBS+0.1% Tween 20 and blocking buffer with 3% BSA in TBS+0.1% Tween 20, for 3 minutes in each solution. 
         [0121]    The imaging of the glasses was performed in Agilent G2565CA Microarray Scanner System. Three replicas of the each peptide incubation were performed and analyzed. 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Normalized intensity levels of peptide sequences. 
               
             
          
           
               
                   
                 Number of 
                   
                 Hydrophobic 
                 Intensity level 
               
               
                   
                 amino 
                 Cysteine 
                 amino acids 
                 (average ± 
               
               
                 Sequence 
                 acids 
                 content 
                 content 
                 standard deviation) 
               
               
                   
               
               
                 SEQ. ID 
                 10 
                 20% 
                 50% 
                 0.990 ± 0.014 
               
               
                 NO: 179 
               
               
                 SEQ. ID 
                 10 
                 30% 
                 60% 
                 1.000 ± 0.000 
               
               
                 NO: 75 
               
               
                 SEQ. ID 
                 10 
                 30% 
                 40% 
                 1.000 ± 0.000 
               
               
                 NO: 432 
               
               
                 SEQ. ID 
                 10 
                 40% 
                 30% 
                 1.000 ± 0.000 
               
               
                 NO: 951 
               
               
                 SEQ. ID 
                 11 
                 46% 
                 18% 
                 1.000 ± 0.000 
               
               
                 NO: 1108 
               
               
                 SEQ. ID 
                 11 
                 46% 
                  9% 
                 1.000 ± 0.000 
               
               
                 NO: 1131 
               
               
                 X 3 CX 5 CX 3   
                 13 
                 15% 
                 38% 
                 0.184 ± 0.084 
               
               
                   
               
             
          
         
       
     
         [0122]    The peptides SEQ. ID NO:75, SEQ. ID NO:432, SEQ. ID NO:951, SEQ. ID NO:1108, SEQ. ID NO:1131, with percentage of cysteine ranging from 30% to 46%, such as and percentage of hydrophobic amino acids ranging from 9% to 60% were able to obtain an intensity of 1, indicating a very high affinity to keratin. The peptide SEQ. ID NO:179, with 20% and 50% of cysteine and hydrophobic content, respectively showed an slightly inferior but still very high intensity (0.990±0.014). These peptides were compared with a peptide similar to the one described in Fernandes et al. (Fernandes, Lima, Loureiro, Gomes, &amp; Cavaco-Paulo, 2012) containing 2 cysteines in a 13 amino acids sequence. The reduced percentage of cysteine (15%) and higher number of amino acids in the sequence (13 amino acids) lead to a decrease in the intensity to 0.184±0.084, showing an inferior affinity to keratin. This suggests that the higher number of amino acids difficult the reaction of the peptide with the hair keratins. This inferior affinity to keratin leads to less fixation of the peptides in the hair in posterior treatments and consequently providing less improvements in the recovery of the hair characteristics. 
       List of Peptide Sequences 
       [0123]    The sequences of peptides are described by one letter code of amino acids. The code is as follows: 
         [0000]    
       
         
               
               
             
           
               
                   
                   
               
             
             
               
                   
                 Amino acid-One Letter Code 
               
               
                   
                   
               
               
                   
                 Histidine-H 
               
               
                   
                   
               
               
                   
                 Arginine-R 
               
               
                   
                   
               
               
                   
                 Lysine-K 
               
               
                   
                   
               
               
                   
                 Isoleucine-I 
               
               
                   
                   
               
               
                   
                 Phenylalanine-F 
               
               
                   
                   
               
               
                   
                 Leucine- L 
               
               
                   
                   
               
               
                   
                 Tryptophan-W 
               
               
                   
                   
               
               
                   
                 Alanine-A 
               
               
                   
                   
               
               
                   
                 Methionine-M 
               
               
                   
                   
               
               
                   
                 Proline-P 
               
               
                   
                   
               
               
                   
                 Valine-V 
               
               
                   
                   
               
               
                   
                 Cysteine-C 
               
               
                   
                   
               
               
                   
                 Asparagine-N 
               
               
                   
                   
               
               
                   
                 Glycine-G 
               
               
                   
                   
               
               
                   
                 Serine-S 
               
               
                   
                   
               
               
                   
                 Glutamine-Q 
               
               
                   
                   
               
               
                   
                 Tyrosine-Y 
               
               
                   
                   
               
               
                   
                 Threonine-T 
               
               
                   
                   
               
               
                   
                 Aspartic acid-D 
               
               
                   
                   
               
               
                   
                 Glutamic acid-E 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1 
               
               
                   
                 APCAPRPSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 2 
               
               
                   
                 EACVPSVPCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 3 
               
               
                   
                 ESCGTASGCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 4 
               
               
                   
                 GLCAGTSACL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 5 
               
               
                   
                 GVCGPSPPCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 6 
               
               
                   
                 HGCTLPGACN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 7 
               
               
                   
                 HSCTLPGACN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 8 
               
               
                   
                 KDCLQNSLCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 9 
               
               
                   
                 LPCLPAASCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 10 
               
               
                   
                 LPCYFTGSCN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 11 
               
               
                   
                 NFCLPSLSCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 12 
               
               
                   
                 NPCATTNACD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 13 
               
               
                   
                 NPCATTNACE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 14 
               
               
                   
                 NPCATTNACS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 15 
               
               
                   
                 NPCGLRARCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 16 
               
               
                   
                 NPCGPRSRCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 17 
               
               
                   
                 NPCSTPASCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 18 
               
               
                   
                 NPCSTSPSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 19 
               
               
                   
                 PACTSSSPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 20 
               
               
                   
                 SKCHESTVCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 21 
               
               
                   
                 SPCVPRTVCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 22 
               
               
                   
                 SSCSVETACL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 23 
               
               
                   
                 SVCSSGVNCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 24 
               
               
                   
                 TACPLPGTCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 25 
               
               
                   
                 TNCSPRPICV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 26 
               
               
                   
                 TSCVPPAPCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 27 
               
               
                   
                 TTCTSSNTCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 28 
               
               
                   
                 VPCVPSVPCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 29 
               
               
                   
                 ATCGPSACIT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 30 
               
               
                   
                 GPCISNPCGL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 31 
               
               
                   
                 GPCLSNPCTS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 32 
               
               
                   
                 GSCVTNPCGP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 33 
               
               
                   
                 LTCFSITCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 34 
               
               
                   
                 NPCSTPSCTT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 35 
               
               
                   
                 PSCVTAPCAP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 36 
               
               
                   
                 SDCSSTHCSP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 37 
               
               
                   
                 SLCLPPTCHT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 38 
               
               
                   
                 SLCNLGSCGP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 39 
               
               
                   
                 SPCLVGNCAW 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 40 
               
               
                   
                 TACLPGTCAT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 41 
               
               
                   
                 TSCLPALCLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 42 
               
               
                   
                 TSCSSRPCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 43 
               
               
                   
                 TTCGGGSCGV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 44 
               
               
                   
                 VNCRPELCLG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 45 
               
               
                   
                 YVCQPMACLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 46 
               
               
                   
                 AFSCISACGP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 47 
               
               
                   
                 GSVCSAPCNG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 48 
               
               
                   
                 GVVCGDLCAS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 49 
               
               
                   
                 GVVCGDLCVS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 50 
               
               
                   
                 LTGCLLPCYF 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 51 
               
               
                   
                 NEDCKLPCNP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 52 
               
               
                   
                 NFSCVSACGP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 53 
               
               
                   
                 PPTCHTACPL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 54 
               
               
                   
                 PQPCATACKP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 55 
               
               
                   
                 SEDCKLPCNP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 56 
               
               
                   
                 SLGCRTSCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 57 
               
               
                   
                 SLSCRTSCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 58 
               
               
                   
                 SSSCPLGCTM 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 59 
               
               
                   
                 TGSCNSPCLV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 60 
               
               
                   
                 TSSCPLGCTM 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 61 
               
               
                   
                 VGSCGSSCRK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 62 
               
               
                   
                 VGVCGGSCKR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 63 
               
               
                   
                 VSNCNWFCEG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 64 
               
               
                   
                 ACGPRPGRCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 65 
               
               
                   
                 ACGPRPSRCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 66 
               
               
                   
                 CAPRPSCGPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 67 
               
               
                   
                 CEPCSAYVIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 68 
               
               
                   
                 CGLRARCGPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 69 
               
               
                   
                 CGPRPGRCCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 70 
               
               
                   
                 CGPRPSRCCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 71 
               
               
                   
                 CGPRSRCGPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 72 
               
               
                   
                 CGTSQKGCCN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 73 
               
               
                   
                 CHGCTLPGAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 74 
               
               
                   
                 CHSCTLPGAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 75 
               
               
                   
                 CLPCLPAASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 76 
               
               
                   
                 CLPPTCHTAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 77 
               
               
                   
                 CLSNPCTSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 78 
               
               
                   
                 CLVGNCAWCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 79 
               
               
                   
                 CNPCSTPASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 80 
               
               
                   
                 CNPCSTPSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 81 
               
               
                   
                 CNPCSTSPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 82 
               
               
                   
                 CNSPCLVGNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 83 
               
               
                   
                 CRTSCSSRPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 84 
               
               
                   
                 CSLKEHCSAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 85 
               
               
                   
                 CSPRPICVPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 86 
               
               
                   
                 CSSTMSYSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 87 
               
               
                   
                 CSTPASCTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 88 
               
               
                   
                 CSTPSCTTCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 89 
               
               
                   
                 CTSCVPPAPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 90 
               
               
                   
                 CTSSNTCEPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 91 
               
               
                   
                 CVPPAPCTPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 92 
               
               
                   
                 CVPPSCHGCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 93 
               
               
                   
                 CVPPSCHSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 94 
               
               
                   
                 DCKLPCNPCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 95 
               
               
                   
                 DCKLPCNPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 96 
               
               
                   
                 PCGTSQKGCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 97 
               
               
                   
                 PCLSNPCTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 98 
               
               
                   
                 PCLVGNCAWC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 99 
               
               
                   
                 PCNPCSTPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 100 
               
               
                   
                 PCSTPSCTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 101 
               
               
                   
                 PCTTCGPTCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 102 
               
               
                   
                 PCVPPSCHGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 103 
               
               
                   
                 PCVPPSCHSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 104 
               
               
                   
                 SCCLPSLGCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 105 
               
               
                   
                 SCSEELQCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 106 
               
               
                   
                 SCSPCSTTCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 107 
               
               
                   
                 ASCSTSGTCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 108 
               
               
                   
                 ASCYIPVGCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 109 
               
               
                   
                 ASCYVPVSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 110 
               
               
                   
                 AVCTLPSSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 111 
               
               
                   
                 DLCPTSVSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 112 
               
               
                   
                 EICWEPTSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 113 
               
               
                   
                 ETCGEPTSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 114 
               
               
                   
                 ETCNETTSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 115 
               
               
                   
                 ETCWRPNSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 116 
               
               
                   
                 GYCGYRPFCF 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 117 
               
               
                   
                 KTCWEPASCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 118 
               
               
                   
                 KTCWEPTSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 119 
               
               
                   
                 LDCVDTTPCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 120 
               
               
                   
                 LGCGYGSFCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 121 
               
               
                   
                 NSCGYGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 122 
               
               
                   
                 NYCPSNTMCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 123 
               
               
                   
                 PACVTSYSCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 124 
               
               
                   
                 PDCHVEGTCL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 125 
               
               
                   
                 PDCRVEGTCL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 126 
               
               
                   
                 PICSEPSPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 127 
               
               
                   
                 PICYIFKPCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 128 
               
               
                   
                 PLCYISNSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 129 
               
               
                   
                 PPCGQPTPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 130 
               
               
                   
                 PPCHIPQPCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 131 
               
               
                   
                 PSCGRLASCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 132 
               
               
                   
                 PSCSESSICQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 133 
               
               
                   
                 PSCSEVTSCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 134 
               
               
                   
                 PSCSTSGTCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 135 
               
               
                   
                 PSCSVSSGCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 136 
               
               
                   
                 PSCTESDSCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 137 
               
               
                   
                 PSCYQTSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 138 
               
               
                   
                 PTCFLLNSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 139 
               
               
                   
                 PTCSVTSSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 140 
               
               
                   
                 PTCWLLNNCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 141 
               
               
                   
                 PTCYQRTSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 142 
               
               
                   
                 PTCYRRTSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 143 
               
               
                   
                 PTCYVVKRCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 144 
               
               
                   
                 PVCFEATICE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 145 
               
               
                   
                 PVCFEATVCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 146 
               
               
                   
                 PVCSRPASCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 147 
               
               
                   
                 PVCSWVPACS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 148 
               
               
                   
                 QTCNESSYCL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 149 
               
               
                   
                 QTCWEPTSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 150 
               
               
                   
                 SFCRLGYGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 151 
               
               
                   
                 SFCRRGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 152 
               
               
                   
                 SLCGYGYGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 153 
               
               
                   
                 SLCSTEVSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 154 
               
               
                   
                 SNCFGQLNCL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 155 
               
               
                   
                 SPCGQPTPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 156 
               
               
                   
                 SSCDQSSSCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 157 
               
               
                   
                 SSCGQSSSCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 158 
               
               
                   
                 SVCPEPVSCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 159 
               
               
                   
                 TFCSFDKSCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 160 
               
               
                   
                 TICSSDKSCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 161 
               
               
                   
                 TLCVESSPCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 162 
               
               
                   
                 TPCYQQSSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 163 
               
               
                   
                 VTCSRQTTCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 164 
               
               
                   
                 YGCGYGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 165 
               
               
                   
                 YGCGYGSGCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 166 
               
               
                   
                 YGCIHSTHCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 167 
               
               
                   
                 AACEPSACQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 168 
               
               
                   
                 AACEPSPCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 169 
               
               
                   
                 AACTMSVCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 170 
               
               
                   
                 ADCLGGICLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 171 
               
               
                   
                 ALCLPSSCHS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 172 
               
               
                   
                 ALCSPSTCQL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 173 
               
               
                   
                 APCLALVCAP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 174 
               
               
                   
                 APCLSLVCTP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 175 
               
               
                   
                 APCLTLVCTP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 176 
               
               
                   
                 APCVALLCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 177 
               
               
                   
                 ASCGSLLCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 178 
               
               
                   
                 ASCLSFLCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 179 
               
               
                   
                 ASCVSLLCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 180 
               
               
                   
                 AVCEPSPCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 181 
               
               
                   
                 AVCLPVSCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 182 
               
               
                   
                 AVCVPVRCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 183 
               
               
                   
                 AVCVPVSCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 184 
               
               
                   
                 DLCSPSTCQL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 185 
               
               
                   
                 DSCGSSSCGP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 186 
               
               
                   
                 DSCVQSNCFP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 187 
               
               
                   
                 FNCSTRNCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 188 
               
               
                   
                 GGCGSYGCSQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 189 
               
               
                   
                 GSCGFGSCYG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 190 
               
               
                   
                 GSCSSRKCFS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 191 
               
               
                   
                 GVCLPSTCPH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 192 
               
               
                   
                 HSCEGYLCYS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 193 
               
               
                   
                 IVCAAPSCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 194 
               
               
                   
                 KTCSTTGCDP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 195 
               
               
                   
                 LACVSQPCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 196 
               
               
                   
                 LGCGYGGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 197 
               
               
                   
                 LSCGSRSCSS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 198 
               
               
                   
                 LVCTPVSCVS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 199 
               
               
                   
                 NGCQETYCEP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 200 
               
               
                   
                 NSCRSLSCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 201 
               
               
                   
                 PACVISTCPR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 202 
               
               
                   
                 PGCLNQSCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 203 
               
               
                   
                 PPCGTAPCLT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 204 
               
               
                   
                 PPCTTALCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 205 
               
               
                   
                 PPCYLVSCTP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 206 
               
               
                   
                 PRCTRPICEP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 207 
               
               
                   
                 PSCPVSSCAQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 208 
               
               
                   
                 PSCQPSVCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 209 
               
               
                   
                 PSCSVSNCYQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 210 
               
               
                   
                 PSCSVSSCAQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 211 
               
               
                   
                 PSCTSVLCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 212 
               
               
                   
                 PTCKSPSCEP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 213 
               
               
                   
                 PTCVISSCPR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 214 
               
               
                   
                 PTCVISTCPR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 215 
               
               
                   
                 PTCYQTICFR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 216 
               
               
                   
                 PVCGGVSCHT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 217 
               
               
                   
                 PVCGRVSCHT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 218 
               
               
                   
                 PVCNKPVCFV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 219 
               
               
                   
                 PVCPTPTCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 220 
               
               
                   
                 PVCRSTYCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 221 
               
               
                   
                 PVCSKSVCYV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 222 
               
               
                   
                 PVCSRPACYS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 223 
               
               
                   
                 PVCYVPTCSE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 224 
               
               
                   
                 QFCLSKSCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 225 
               
               
                   
                 RPCERTACQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 226 
               
               
                   
                 RSCQTSFCGF 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 227 
               
               
                   
                 RSCSSLGCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 228 
               
               
                   
                 RSCYSVGCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 229 
               
               
                   
                 RVCLPGSCDS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 230 
               
               
                   
                 SFCGFPSCST 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 231 
               
               
                   
                 SFCGYPSCST 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 232 
               
               
                   
                 SGCDPASCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 233 
               
               
                   
                 SGCGGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 234 
               
               
                   
                 SGCQPSSCLA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 235 
               
               
                   
                 SHCQPPHCQL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 236 
               
               
                   
                 SICQPATCVA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 237 
               
               
                   
                 SLCVPVSCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 238 
               
               
                   
                 SNCLPTSCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 239 
               
               
                   
                 SPCLVSSCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 240 
               
               
                   
                 SPCQQSSCQE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 241 
               
               
                   
                 SPCQQSYCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 242 
               
               
                   
                 SPCSPAVCVS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 243 
               
               
                   
                 SRCQQPSCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 244 
               
               
                   
                 SRCYRPHCGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 245 
               
               
                   
                 SSCAPIYCRR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 246 
               
               
                   
                 SSCAPVYCRR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 247 
               
               
                   
                 SSCGKGGCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 248 
               
               
                   
                 SSCGKRGCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 249 
               
               
                   
                 SSCLPVSCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 250 
               
               
                   
                 SSCQPAYCTS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 251 
               
               
                   
                 SSCQPSYCRQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 252 
               
               
                   
                 SSCQPVVCEP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 253 
               
               
                   
                 SSCTAVVCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 254 
               
               
                   
                 SSCYQPFCRS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 255 
               
               
                   
                 SSCYRPICGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 256 
               
               
                   
                 SSCYRPTCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 257 
               
               
                   
                 SVCMSGSCQA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 258 
               
               
                   
                 SVCSDQGCDQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 259 
               
               
                   
                 SVCSDQGCGL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 260 
               
               
                   
                 SVCSDQGCGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 261 
               
               
                   
                 SVCSDQGCSQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 262 
               
               
                   
                 SVCSDQSCGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 263 
               
               
                   
                 SVCSHQGCGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 264 
               
               
                   
                 SVCSHQGCGR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 265 
               
               
                   
                 SVCVPVSCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 266 
               
               
                   
                 SYCRQASCVS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 267 
               
               
                   
                 TACEPSACQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 268 
               
               
                   
                 TICTASPCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 269 
               
               
                   
                 TSCPETSCLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 270 
               
               
                   
                 TSCQMTNCEQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 271 
               
               
                   
                 TSCQPVHCET 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 272 
               
               
                   
                 TSCQPVLCKS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 273 
               
               
                   
                 TSCQPVLCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 274 
               
               
                   
                 TSCVGFVCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 275 
               
               
                   
                 TSCVSNPCQV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 276 
               
               
                   
                 TTCFQPTCVS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 277 
               
               
                   
                 TTCFQPTCVT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 278 
               
               
                   
                 TTCFQPTCVY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 279 
               
               
                   
                 TTCISNPCST 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 280 
               
               
                   
                 TWCQGSSCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 281 
               
               
                   
                 VGCQSSVCVP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 282 
               
               
                   
                 VPCQPSTCVF 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 283 
               
               
                   
                 VSCEPSPCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 284 
               
               
                   
                 VSCGGPICLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 285 
               
               
                   
                 VSCKPVLCVA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 286 
               
               
                   
                 VSCPSTSCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 287 
               
               
                   
                 VSCQSSVCMP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 288 
               
               
                   
                 VSCTRIVCVA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 289 
               
               
                   
                 VTCEPSPCQS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 290 
               
               
                   
                 VTCQTTVCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 291 
               
               
                   
                 YGCGYEGCRY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 292 
               
               
                   
                 AGSCQPSCSE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 293 
               
               
                   
                 ALLCRPLCGV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 294 
               
               
                   
                 ALVCEPVCLR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 295 
               
               
                   
                 ATICEPSCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 296 
               
               
                   
                 ATTCEPSCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 297 
               
               
                   
                 ATVCEPSCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 298 
               
               
                   
                 EGTCLPPCYL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 299 
               
               
                   
                 FSTCRPSCSG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 300 
               
               
                   
                 GFVCQPMCSH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 301 
               
               
                   
                 GLDCGYGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 302 
               
               
                   
                 GLGCGYGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 303 
               
               
                   
                 GLGCSYGCGH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 304 
               
               
                   
                 GLGCSYGCGL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 305 
               
               
                   
                 GSGCGYGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 306 
               
               
                   
                 GTGCGYGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 307 
               
               
                   
                 GVSCHTTCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 308 
               
               
                   
                 GYACNFPCSY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 309 
               
               
                   
                 GYGCGYGCGF 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 310 
               
               
                   
                 HSPCQASCYV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 311 
               
               
                   
                 HTSCSPACQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 312 
               
               
                   
                 HTSCSSGCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 313 
               
               
                   
                 IRWCHPDCHV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 314 
               
               
                   
                 IRWCRPDCRV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 315 
               
               
                   
                 ISSCGTGCGI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 316 
               
               
                   
                 KGGCGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 317 
               
               
                   
                 KGGCGSSCSQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 318 
               
               
                   
                 LVTCQDSCGS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 319 
               
               
                   
                 LVTCQESCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 320 
               
               
                   
                 MSICSSACTD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 321 
               
               
                   
                 MSICSSACTN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 322 
               
               
                   
                 MSVCSSACSD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 323 
               
               
                   
                 PAICEPSCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 324 
               
               
                   
                 PASCQKSCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 325 
               
               
                   
                 PIYCRRTCYH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 326 
               
               
                   
                 PNSCQTLCVE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 327 
               
               
                   
                 PQPCVPTCFL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 328 
               
               
                   
                 PSACQSGCTS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 329 
               
               
                   
                 PSPCEPSCSE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 330 
               
               
                   
                 PSPCQASCYI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 331 
               
               
                   
                 PSPCQSGCIS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 332 
               
               
                   
                 PSPCQSGCTD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 333 
               
               
                   
                 PSPCQSGCTS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 334 
               
               
                   
                 PTACQPTCYQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 335 
               
               
                   
                 PTACQPTCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 336 
               
               
                   
                 PTPCSTTCRT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 337 
               
               
                   
                 PTSCQKSCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 338 
               
               
                   
                 PTSCQPSCES 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 339 
               
               
                   
                 PTSCQTSCTL 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 340 
               
               
                   
                 PVICEPSCSV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 341 
               
               
                   
                 PVSCVPVCSG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 342 
               
               
                   
                 PVTCVPRCTR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 343 
               
               
                   
                 PVYCRRTCYH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 344 
               
               
                   
                 PVYCRRTCYY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 345 
               
               
                   
                 PVYCVPVCSG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 346 
               
               
                   
                 QPGCESPCEP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 347 
               
               
                   
                 QQSCVSSCRR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 348 
               
               
                   
                 QTSCGSSCGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 349 
               
               
                   
                 QTTCHPSCGM 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 350 
               
               
                   
                 QTTCRPSCGV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 351 
               
               
                   
                 RGGCGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 352 
               
               
                   
                 RLACYSLCSG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 353 
               
               
                   
                 RPACYRPCYS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 354 
               
               
                   
                 RPFCFRRCYS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 355 
               
               
                   
                 RPICRPICSG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 356 
               
               
                   
                 RPLCYRRCYS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 357 
               
               
                   
                 RSPCQASCYV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 358 
               
               
                   
                 RVSCHTTCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 359 
               
               
                   
                 SAICRPTCPR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 360 
               
               
                   
                 SDSCKRDCKK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 361 
               
               
                   
                 SEGCGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 362 
               
               
                   
                 SFLCRPACSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 363 
               
               
                   
                 SGGCGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 364 
               
               
                   
                 SGGCGSSCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 365 
               
               
                   
                 SGSCQAACGQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 366 
               
               
                   
                 SLLCHPVCKS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 367 
               
               
                   
                 SLLCHPVCRS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 368 
               
               
                   
                 SLLCRPACSP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 369 
               
               
                   
                 SLLCRPACSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 370 
               
               
                   
                 SLLCRPICRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 371 
               
               
                   
                 SLLCRPMCSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 372 
               
               
                   
                 SLLCRPTCSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 373 
               
               
                   
                 SLLCRPVCQP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 374 
               
               
                   
                 SLLCRPVCRP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 375 
               
               
                   
                 SLLCRPVCRS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 376 
               
               
                   
                 SLLCRPVCSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 377 
               
               
                   
                 SNPCQVTCSR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 378 
               
               
                   
                 SRGCGSGCGG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 379 
               
               
                   
                 SRSCQSPCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 380 
               
               
                   
                 SRSCQSSCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 381 
               
               
                   
                 SSGCGYGCGY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 382 
               
               
                   
                 SSGCPMACPG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 383 
               
               
                   
                 SSICQPICSE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 384 
               
               
                   
                 SSPCHTSCYY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 385 
               
               
                   
                 SSPCQPTCYV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 386 
               
               
                   
                 SSPCQQSCYV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 387 
               
               
                   
                 SSPCQTSCYR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 388 
               
               
                   
                 SSSCQQSCRV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 389 
               
               
                   
                 STVCQPACGV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 390 
               
               
                   
                 TDNCQETCGE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 391 
               
               
                   
                 TQPCYEPCLP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 392 
               
               
                   
                 TSSCGTGCGI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 393 
               
               
                   
                 TSSCQPSCGR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 394 
               
               
                   
                 TSSCTTPCYQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 395 
               
               
                   
                 TSVCLPGCLN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 396 
               
               
                   
                 TTVCLPGCLN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 397 
               
               
                   
                 VANCQAPCST 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 398 
               
               
                   
                 VDDCPESCWP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 399 
               
               
                   
                 VKRCPSVCPE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 400 
               
               
                   
                 VSSCQPSCSE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 401 
               
               
                   
                 YEGCRYGCGH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 402 
               
               
                   
                 YGRCRHGCHS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 403 
               
               
                   
                 YGYCRPSCYG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 404 
               
               
                   
                 YRDCQKTCWE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 405 
               
               
                   
                 YRGCQEICWE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 406 
               
               
                   
                 YRGCQETCWR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 407 
               
               
                   
                 YRGCQQTCWE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 408 
               
               
                   
                 YRSCRPSCYG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 409 
               
               
                   
                 GGVCGPSPPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 410 
               
               
                   
                 GVCGPSPPCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 411 
               
               
                   
                 VCGPSPPCIT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 412 
               
               
                   
                 CGPSPPCITT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 413 
               
               
                   
                 CAPIYCRRTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 414 
               
               
                   
                 CAPSPCQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 415 
               
               
                   
                 CAPSPCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 416 
               
               
                   
                 CAPVYCRRTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 417 
               
               
                   
                 CASSPCQQAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 418 
               
               
                   
                 CASSSCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 419 
               
               
                   
                 CASSSCQQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 420 
               
               
                   
                 CCGNFSSHSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 421 
               
               
                   
                 CCGYGGLGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 422 
               
               
                   
                 CCNYYGNSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 423 
               
               
                   
                 CCNYYRNSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 424 
               
               
                   
                 CCSRNFSSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 425 
               
               
                   
                 CDAGSCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 426 
               
               
                   
                 CDPCSLQEGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 427 
               
               
                   
                 CDPSPCEPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 428 
               
               
                   
                 CDPVICEPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 429 
               
               
                   
                 CDQGLCQETC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 430 
               
               
                   
                 CEATTCEPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 431 
               
               
                   
                 CELPCGTPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 432 
               
               
                   
                 CEPAICEPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 433 
               
               
                   
                 CEPPCGTAPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 434 
               
               
                   
                 CEPPCSAPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 435 
               
               
                   
                 CEPRSCASSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 436 
               
               
                   
                 CEPSACQSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 437 
               
               
                   
                 CEPSCSVSNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 438 
               
               
                   
                 CEPSCSVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 439 
               
               
                   
                 CEPSPCQSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 440 
               
               
                   
                 CEPTACQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 441 
               
               
                   
                 CEPTSCQTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 442 
               
               
                   
                 CEPVCLRPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 443 
               
               
                   
                 CETSSCQPRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 444 
               
               
                   
                 CETTCFQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 445 
               
               
                   
                 CFQPTCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 446 
               
               
                   
                 CFQPTCVTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 447 
               
               
                   
                 CFQPTCVYSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 448 
               
               
                   
                 CGCGFRRLGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 449 
               
               
                   
                 CGCGYRGLDC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 450 
               
               
                   
                 CGCNGYYGCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 451 
               
               
                   
                 CGFGSCYGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 452 
               
               
                   
                 CGGSGCGGSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 453 
               
               
                   
                 CGGSGSSCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 454 
               
               
                   
                 CGGVSCHTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 455 
               
               
                   
                 CGKGGCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 456 
               
               
                   
                 CGKRGCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 457 
               
               
                   
                 CGQDLCQETC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 458 
               
               
                   
                 CGQTSCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 459 
               
               
                   
                 CGQVLCQETC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 460 
               
               
                   
                 CGRDLCQETC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 461 
               
               
                   
                 CGRVSCHTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 462 
               
               
                   
                 CGSCGFGSCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 463 
               
               
                   
                 CGSCGGSKGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 464 
               
               
                   
                 CGSGCGVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 465 
               
               
                   
                 CGSLLCRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 466 
               
               
                   
                 CGSRCYVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 467 
               
               
                   
                 CGSSSCGPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 468 
               
               
                   
                 CGSVCSDQGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 469 
               
               
                   
                 CGSVCSDQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 470 
               
               
                   
                 CGSVCSHQGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 471 
               
               
                   
                 CGSYGCSQCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 472 
               
               
                   
                 CGVCLPSTCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 473 
               
               
                   
                 CGYEGCRYGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 474 
               
               
                   
                 CGYGCGYGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 475 
               
               
                   
                 CGYGGCGYGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 476 
               
               
                   
                 CGYGSFCGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 477 
               
               
                   
                 CGYGSGCGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 478 
               
               
                   
                 CHPSCGMSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 479 
               
               
                   
                 CHPSCSISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 480 
               
               
                   
                 CHPTCYQTIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 481 
               
               
                   
                 CHTSCSPACQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 482 
               
               
                   
                 CHTSCSSGCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 483 
               
               
                   
                 CHTTCYRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 484 
               
               
                   
                 CHTTCYRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 485 
               
               
                   
                 CIHSPCQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 486 
               
               
                   
                 CIHSTHCGCN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 487 
               
               
                   
                 CIRSPCQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 488 
               
               
                   
                 CISSCYRPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 489 
               
               
                   
                 CISSPCQQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 490 
               
               
                   
                 CKPCSSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 491 
               
               
                   
                 CKPSCSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 492 
               
               
                   
                 CKPVCFKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 493 
               
               
                   
                 CKPVCYVPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 494 
               
               
                   
                 CKPVSCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 495 
               
               
                   
                 CKPVYCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 496 
               
               
                   
                 CKTVYCKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 497 
               
               
                   
                 CLNQSCGSNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 498 
               
               
                   
                 CLNQSCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 499 
               
               
                   
                 CLPGCLNQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 500 
               
               
                   
                 CLPGSCDSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 501 
               
               
                   
                 CLPPCYLVSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 502 
               
               
                   
                 CLPTSCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 503 
               
               
                   
                 CLSFLCRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 504 
               
               
                   
                 CLVSSCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 505 
               
               
                   
                 CMPSPCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 506 
               
               
                   
                 CMSGSCQAAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 507 
               
               
                   
                 CNESSYCLPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 508 
               
               
                   
                 CPASCVSLLC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 509 
               
               
                   
                 CPMACPGSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 510 
               
               
                   
                 CPSSCTAVVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 511 
               
               
                   
                 CPVTCEPSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 512 
               
               
                   
                 CQAACEPSAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 513 
               
               
                   
                 CQAACEPSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 514 
               
               
                   
                 CQAACGQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 515 
               
               
                   
                 CQAPCSTKNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 516 
               
               
                   
                 CQAVCEPSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 517 
               
               
                   
                 CQDSCGSSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 518 
               
               
                   
                 CQHSSCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 519 
               
               
                   
                 CQISSCGTGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 520 
               
               
                   
                 CQKSSCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 521 
               
               
                   
                 CQPMCSHAAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 522 
               
               
                   
                 CQPPCTTALC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 523 
               
               
                   
                 CQPSCESSFC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 524 
               
               
                   
                 CQPSCSESTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 525 
               
               
                   
                 CQPSCTSVLC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 526 
               
               
                   
                 CQPTCGGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 527 
               
               
                   
                 CQPTCSRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 528 
               
               
                   
                 CQPVCPTPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 529 
               
               
                   
                 CQPVLCKSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 530 
               
               
                   
                 CQPVVCEPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 531 
               
               
                   
                 CQQPSCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 532 
               
               
                   
                 CQQSCRVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 533 
               
               
                   
                 CQQSCYVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 534 
               
               
                   
                 CQQSGCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 535 
               
               
                   
                 CQQSSCHPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 536 
               
               
                   
                 CQQSSCKPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 537 
               
               
                   
                 CQQSSCQLAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 538 
               
               
                   
                 CQQSSCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 539 
               
               
                   
                 CQQSSCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 540 
               
               
                   
                 CQQSSCQSAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 541 
               
               
                   
                 CQQSSCVSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 542 
               
               
                   
                 CQQSYCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 543 
               
               
                   
                 CQSGCISSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 544 
               
               
                   
                 CQSGCTDSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 545 
               
               
                   
                 CQSGCTSSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 546 
               
               
                   
                 CQSSCYRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 547 
               
               
                   
                 CQSVCYQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 548 
               
               
                   
                 CQSVYCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 549 
               
               
                   
                 CQTACEPSAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 550 
               
               
                   
                 CQTSSCGTGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 551 
               
               
                   
                 CQTTCHPSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 552 
               
               
                   
                 CQTTCRPSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 553 
               
               
                   
                 CQTTCYRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 554 
               
               
                   
                 CQTTRCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 555 
               
               
                   
                 CQVTCEPSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 556 
               
               
                   
                 CRNTSCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 557 
               
               
                   
                 CRPACSPLAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 558 
               
               
                   
                 CRPACSRLAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 559 
               
               
                   
                 CRPACSRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 560 
               
               
                   
                 CRPMCSRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 561 
               
               
                   
                 CRPSCGQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 562 
               
               
                   
                 CRPSCGVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 563 
               
               
                   
                 CRPSCSISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 564 
               
               
                   
                 CRPSCSQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 565 
               
               
                   
                 CRPSYCGQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 566 
               
               
                   
                 CRPSYCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 567 
               
               
                   
                 CRPSYCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 568 
               
               
                   
                 CRPTCSRLAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 569 
               
               
                   
                 CRPTCSSGSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 570 
               
               
                   
                 CRPTSCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 571 
               
               
                   
                 CRPVCRSTYC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 572 
               
               
                   
                 CRPVCSRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 573 
               
               
                   
                 CRPVTCVPRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 574 
               
               
                   
                 CRQSSCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 575 
               
               
                   
                 CRTTCFHPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 576 
               
               
                   
                 CRTTCFQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 577 
               
               
                   
                 CRTTCYRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 578 
               
               
                   
                 CRTTYCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 579 
               
               
                   
                 CRVTCEPSPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 580 
               
               
                   
                 CRYGCGHRGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 581 
               
               
                   
                 CSAPCVALLC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 582 
               
               
                   
                 CSDDSGSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 583 
               
               
                   
                 CSEDSSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 584 
               
               
                   
                 CSEDSYSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 585 
               
               
                   
                 CSEGCGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 586 
               
               
                   
                 CSESSPSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 587 
               
               
                   
                 CSESSSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 588 
               
               
                   
                 CSFDKSCRCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 589 
               
               
                   
                 CSGASSLCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 590 
               
               
                   
                 CSGASSPCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 591 
               
               
                   
                 CSGASSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 592 
               
               
                   
                 CSGASTSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 593 
               
               
                   
                 CSGGCGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 594 
               
               
                   
                 CSGGCGSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 595 
               
               
                   
                 CSGISSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 596 
               
               
                   
                 CSKDSSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 597 
               
               
                   
                 CSKGACGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 598 
               
               
                   
                 CSLSCGSRSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 599 
               
               
                   
                 CSQDLCQETC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 600 
               
               
                   
                 CSRGCGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 601 
               
               
                   
                 CSRLSSACCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 602 
               
               
                   
                 CSSCGKGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 603 
               
               
                   
                 CSSCGKRGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 604 
               
               
                   
                 CSSDKSCRCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 605 
               
               
                   
                 CSSGNFSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 606 
               
               
                   
                 CSSSGCGSFC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 607 
               
               
                   
                 CSSSGCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 608 
               
               
                   
                 CSTPCYQPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 609 
               
               
                   
                 CSTTCRTSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 610 
               
               
                   
                 CSWVPACSCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 611 
               
               
                   
                 CTFSPCQQAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 612 
               
               
                   
                 CTMSVCSSAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 613 
               
               
                   
                 CTRPICEPCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 614 
               
               
                   
                 CTSSPCQHAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 615 
               
               
                   
                 CTSSPCQQAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 616 
               
               
                   
                 CTSSPCQQSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 617 
               
               
                   
                 CTSSSCQQAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 618 
               
               
                   
                 CVALLCRPLC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 619 
               
               
                   
                 CVALVCEPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 620 
               
               
                   
                 CVFSSCNTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 621 
               
               
                   
                 CVGFVCQPMC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 622 
               
               
                   
                 CVPRCTRPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 623 
               
               
                   
                 CVPSPCQVAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 624 
               
               
                   
                 CVPSRCQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 625 
               
               
                   
                 CVPSSCQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 626 
               
               
                   
                 CVPVCNKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 627 
               
               
                   
                 CVPVCSKSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 628 
               
               
                   
                 CVPVRCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 629 
               
               
                   
                 CVSLLCRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 630 
               
               
                   
                 CVSLLCRPMC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 631 
               
               
                   
                 CVSLLCRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 632 
               
               
                   
                 CVSLLCRPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 633 
               
               
                   
                 CVSNPCQVTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 634 
               
               
                   
                 CVSRCYRPHC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 635 
               
               
                   
                 CVSSCFRPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 636 
               
               
                   
                 CVSSICQPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 637 
               
               
                   
                 CVSSPCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 638 
               
               
                   
                 CVVSCTPPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 639 
               
               
                   
                 CVVSCTPPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 640 
               
               
                   
                 CYCPKNSIFC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 641 
               
               
                   
                 CYEPCLPRGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 642 
               
               
                   
                 CYRRCYSSCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 643 
               
               
                   
                 GCCGYGGLGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 644 
               
               
                   
                 GCGGCGSGCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 645 
               
               
                   
                 GCGGCGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 646 
               
               
                   
                 GCGGCGSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 647 
               
               
                   
                 GCGGCSSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 648 
               
               
                   
                 GCGGSGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 649 
               
               
                   
                 GCGSGCAGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 650 
               
               
                   
                 GCGSGCGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 651 
               
               
                   
                 GCGSGCGGCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 652 
               
               
                   
                 GCGSSCGGCD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 653 
               
               
                   
                 GCGSSCGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 654 
               
               
                   
                 GCGSSCSQCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 655 
               
               
                   
                 GCGYSSSCCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 656 
               
               
                   
                 GCKGGCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 657 
               
               
                   
                 GCSGCSGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 658 
               
               
                   
                 ICSGASSLCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 659 
               
               
                   
                 ICSGASSPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 660 
               
               
                   
                 MCCNYYGNSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 661 
               
               
                   
                 MCCNYYRNSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 662 
               
               
                   
                 MCYGYGCGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 663 
               
               
                   
                 NCCSRNFSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 664 
               
               
                   
                 PCSLQEGCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 665 
               
               
                   
                 PCSSQSSCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 666 
               
               
                   
                 SCCAPASSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 667 
               
               
                   
                 SCCAPASTCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 668 
               
               
                   
                 SCCAPTSSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 669 
               
               
                   
                 SCCGYRPLCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 670 
               
               
                   
                 SCCVPASSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 671 
               
               
                   
                 SCCVPTSSCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 672 
               
               
                   
                 SCGCSKGACG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 673 
               
               
                   
                 SCGGCDSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 674 
               
               
                   
                 SCGGCGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 675 
               
               
                   
                 SCGGCGSSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 676 
               
               
                   
                 SCGGCKGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 677 
               
               
                   
                 SCGGSKGCCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 678 
               
               
                   
                 SCGSGCRGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 679 
               
               
                   
                 SCYGCGYGCI 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 680 
               
               
                   
                 TCCVPVPSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 681 
               
               
                   
                 TCSDDSGSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 682 
               
               
                   
                 TCSEDSSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 683 
               
               
                   
                 TCSEDSYSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 684 
               
               
                   
                 TCSESSPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 685 
               
               
                   
                 TCSESSSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 686 
               
               
                   
                 TCSKDSSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 687 
               
               
                   
                 TCSRLSSACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 688 
               
               
                   
                 VCCQPTPICD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 689 
               
               
                   
                 VCSEDSSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 690 
               
               
                   
                 VCSGASSLCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 691 
               
               
                   
                 VCSGASSPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 692 
               
               
                   
                 VCSGASSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 693 
               
               
                   
                 VCSGASTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 694 
               
               
                   
                 VCSGDSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 695 
               
               
                   
                 VCSGISSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 696 
               
               
                   
                 YCVPIPSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 697 
               
               
                   
                 CASSCCTPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 698 
               
               
                   
                 CCDNCPPPCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 699 
               
               
                   
                 CCEPCLPRGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 700 
               
               
                   
                 CCGAASSCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 701 
               
               
                   
                 CCGCGGSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 702 
               
               
                   
                 CCGPSSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 703 
               
               
                   
                 CCGSGCGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 704 
               
               
                   
                 CCKPYCSQCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 705 
               
               
                   
                 CCMPVSSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 706 
               
               
                   
                 CCNYYRNCCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 707 
               
               
                   
                 CCPSCVVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 708 
               
               
                   
                 CCPSYCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 709 
               
               
                   
                 CCQPICGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 710 
               
               
                   
                 CCQPICVTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 711 
               
               
                   
                 CCQPTCLSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 712 
               
               
                   
                 CCQPTCLTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 713 
               
               
                   
                 CCQPTCVASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 714 
               
               
                   
                 CCQPTCVTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 715 
               
               
                   
                 CCQPYCHPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 716 
               
               
                   
                 CCQQSSCVSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 717 
               
               
                   
                 CCQSSCFKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 718 
               
               
                   
                 CCQSSCSKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 719 
               
               
                   
                 CCQSSCYKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 720 
               
               
                   
                 CCQTICRSTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 721 
               
               
                   
                 CCQTTCHPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 722 
               
               
                   
                 CCQTTCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 723 
               
               
                   
                 CCRVPTCSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 724 
               
               
                   
                 CCSPGCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 725 
               
               
                   
                 CCSSGCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 726 
               
               
                   
                 CCSSSCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 727 
               
               
                   
                 CCTQEQNCCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 728 
               
               
                   
                 CCVPIPSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 729 
               
               
                   
                 CCVPISSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 730 
               
               
                   
                 CCVPVCYQCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 731 
               
               
                   
                 CCVPVPSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 732 
               
               
                   
                 CCVPVPSCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 733 
               
               
                   
                 CCVPVSSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 734 
               
               
                   
                 CDSSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 735 
               
               
                   
                 CDTCPPPCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 736 
               
               
                   
                 CEPCRRPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 737 
               
               
                   
                 CEPSCCQPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 738 
               
               
                   
                 CEPSCCSAVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 739 
               
               
                   
                 CETSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 740 
               
               
                   
                 CETTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 741 
               
               
                   
                 CFSGCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 742 
               
               
                   
                 CGCSQSNCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 743 
               
               
                   
                 CGCSQSSCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 744 
               
               
                   
                 CGGCGGCGGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 745 
               
               
                   
                 CGGCGGGCCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 746 
               
               
                   
                 CGGCGSGCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 747 
               
               
                   
                 CGGCGSSCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 748 
               
               
                   
                 CGGGCCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 749 
               
               
                   
                 CGGSCCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 750 
               
               
                   
                 CGQSCCRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 751 
               
               
                   
                 CGQSCCRPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 752 
               
               
                   
                 CGSCGCSQCN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 753 
               
               
                   
                 CGSCGCSQCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 754 
               
               
                   
                 CGSFCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 755 
               
               
                   
                 CGSGCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 756 
               
               
                   
                 CGSSCCGSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 757 
               
               
                   
                 CGSSCCQPCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 758 
               
               
                   
                 CGSSCCQPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 759 
               
               
                   
                 CGSSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 760 
               
               
                   
                 CGSSCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 761 
               
               
                   
                 CGSSCCVPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 762 
               
               
                   
                 CGSSCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 763 
               
               
                   
                 CGSSCSQCSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 764 
               
               
                   
                 CGYGSCCGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 765 
               
               
                   
                 CHPRCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 766 
               
               
                   
                 CHPSCCESSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 767 
               
               
                   
                 CHPSCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 768 
               
               
                   
                 CHPTCCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 769 
               
               
                   
                 CHPTCCQTIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 770 
               
               
                   
                 CHPVCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 771 
               
               
                   
                 CHPVCKSTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 772 
               
               
                   
                 CHPVCRSTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 773 
               
               
                   
                 CISSCCHPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 774 
               
               
                   
                 CISSCCKPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 775 
               
               
                   
                 CISSCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 776 
               
               
                   
                 CISSCTPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 777 
               
               
                   
                 CISSSCCPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 778 
               
               
                   
                 CKAVCCVPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 779 
               
               
                   
                 CKPCCSQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 780 
               
               
                   
                 CKPCCSQSRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 781 
               
               
                   
                 CKPCCSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 782 
               
               
                   
                 CKPCCSSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 783 
               
               
                   
                 CKPCSCFSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 784 
               
               
                   
                 CKPCSCSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 785 
               
               
                   
                 CKPCYCSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 786 
               
               
                   
                 CKPICCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 787 
               
               
                   
                 CKPQCCQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 788 
               
               
                   
                 CKPSCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 789 
               
               
                   
                 CKPVCCAPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 790 
               
               
                   
                 CKPVCCKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 791 
               
               
                   
                 CKPVCCKSIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 792 
               
               
                   
                 CKPVCCLPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 793 
               
               
                   
                 CKPVCCVPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 794 
               
               
                   
                 CKPVCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 795 
               
               
                   
                 CKPVCCVSTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 796 
               
               
                   
                 CKPYCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 797 
               
               
                   
                 CKPYCSQCSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 798 
               
               
                   
                 CKSNCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 799 
               
               
                   
                 CKTVCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 800 
               
               
                   
                 CLPPCCVVSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 801 
               
               
                   
                 CLTSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 802 
               
               
                   
                 CNPCCSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 803 
               
               
                   
                 CPESCCELPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 804 
               
               
                   
                 CPESCCEPHC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 805 
               
               
                   
                 CPESCCEPPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 806 
               
               
                   
                 CPFSCPTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 807 
               
               
                   
                 CPGDCFTCCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 808 
               
               
                   
                 CPSCVVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 809 
               
               
                   
                 CPSYCVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 810 
               
               
                   
                 CPTTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 811 
               
               
                   
                 CQETCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 812 
               
               
                   
                 CQHACCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 813 
               
               
                   
                 CQNTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 814 
               
               
                   
                 CQPACCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 815 
               
               
                   
                 CQPACCTASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 816 
               
               
                   
                 CQPACCTSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 817 
               
               
                   
                 CQPACCTTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 818 
               
               
                   
                 CQPACCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 819 
               
               
                   
                 CQPACCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 820 
               
               
                   
                 CQPCCHPTCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 821 
               
               
                   
                 CQPCCRPTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 822 
               
               
                   
                 CQPICCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 823 
               
               
                   
                 CQPICGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 824 
               
               
                   
                 CQPICVTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 825 
               
               
                   
                 CQPNCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 826 
               
               
                   
                 CQPRCCETSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 827 
               
               
                   
                 CQPSCCRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 828 
               
               
                   
                 CQPSCCSTPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 829 
               
               
                   
                 CQPSCCSTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 830 
               
               
                   
                 CQPSCCVPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 831 
               
               
                   
                 CQPSCCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 832 
               
               
                   
                 CQPTCCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 833 
               
               
                   
                 CQPTCCHPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 834 
               
               
                   
                 CQPTCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 835 
               
               
                   
                 CQPTCCRPRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 836 
               
               
                   
                 CQPTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 837 
               
               
                   
                 CQPTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 838 
               
               
                   
                 CQPTCLSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 839 
               
               
                   
                 CQPTCLTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 840 
               
               
                   
                 CQPTCVASCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 841 
               
               
                   
                 CQPTCVTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 842 
               
               
                   
                 CQPVCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 843 
               
               
                   
                 CQPYCHPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 844 
               
               
                   
                 CQQACCMPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 845 
               
               
                   
                 CQQACCVPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 846 
               
               
                   
                 CQQACCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 847 
               
               
                   
                 CQQSCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 848 
               
               
                   
                 CQQSCCVSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 849 
               
               
                   
                 CQSMCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 850 
               
               
                   
                 CQSNCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 851 
               
               
                   
                 CQSSCCKPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 852 
               
               
                   
                 CQSSCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 853 
               
               
                   
                 CQSSCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 854 
               
               
                   
                 CQSSCFKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 855 
               
               
                   
                 CQSSCSKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 856 
               
               
                   
                 CQSVCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 857 
               
               
                   
                 CQTICRSTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 858 
               
               
                   
                 CQTTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 859 
               
               
                   
                 CQTTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 860 
               
               
                   
                 CRATCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 861 
               
               
                   
                 CRGCGPSCCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 862 
               
               
                   
                 CRPACCETTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 863 
               
               
                   
                 CRPACCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 864 
               
               
                   
                 CRPCCWATTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 865 
               
               
                   
                 CRPICRPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 866 
               
               
                   
                 CRPLCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 867 
               
               
                   
                 CRPQCCQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 868 
               
               
                   
                 CRPQCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 869 
               
               
                   
                 CRPRCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 870 
               
               
                   
                 CRPSCCESSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 871 
               
               
                   
                 CRPSCCETTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 872 
               
               
                   
                 CRPSCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 873 
               
               
                   
                 CRPSCCKPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 874 
               
               
                   
                 CRPSCCMSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 875 
               
               
                   
                 CRPSCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 876 
               
               
                   
                 CRPSCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 877 
               
               
                   
                 CRPSCCVSRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 878 
               
               
                   
                 CRPSCCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 879 
               
               
                   
                 CRPTCCETTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 880 
               
               
                   
                 CRPTCCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 881 
               
               
                   
                 CRPTCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 882 
               
               
                   
                 CRPVCCDPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 883 
               
               
                   
                 CRPVCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 884 
               
               
                   
                 CRPVCQPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 885 
               
               
                   
                 CRPVCRPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 886 
               
               
                   
                 CRPVCRPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 887 
               
               
                   
                 CRPVCRSTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 888 
               
               
                   
                 CRPYCCESSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 889 
               
               
                   
                 CRRPVCCDPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 890 
               
               
                   
                 CRSQCCQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 891 
               
               
                   
                 CRTTCCHPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 892 
               
               
                   
                 CRTTCCQPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 893 
               
               
                   
                 CRTTCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 894 
               
               
                   
                 CRTTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 895 
               
               
                   
                 CRTTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 896 
               
               
                   
                 CSCSSCGSCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 897 
               
               
                   
                 CSCSSCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 898 
               
               
                   
                 CSCTSCGSCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 899 
               
               
                   
                 CSPACQPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 900 
               
               
                   
                 CSPGCQPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 901 
               
               
                   
                 CSPSCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 902 
               
               
                   
                 CSQCSCYKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 903 
               
               
                   
                 CSQSNCCKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 904 
               
               
                   
                 CSQSSCCKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 905 
               
               
                   
                 CSSGCGSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 906 
               
               
                   
                 CSSGCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 907 
               
               
                   
                 CSSGCQPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 908 
               
               
                   
                 CSSSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 909 
               
               
                   
                 CSTPCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 910 
               
               
                   
                 CSTTCCQPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 911 
               
               
                   
                 CTAVVCRPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 912 
               
               
                   
                 CTDSCTPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 913 
               
               
                   
                 CTPSCCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 914 
               
               
                   
                 CTRPICEPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 915 
               
               
                   
                 CTSSCTPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 916 
               
               
                   
                 CVPACSCSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 917 
               
               
                   
                 CVPACSCTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 918 
               
               
                   
                 CVPVCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 919 
               
               
                   
                 CVPVCCVPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 920 
               
               
                   
                 CVPVCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 921 
               
               
                   
                 CVSCVSSPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 922 
               
               
                   
                 CVSRCCRPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 923 
               
               
                   
                 CVSSCCKPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 924 
               
               
                   
                 CVSSCCQHSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 925 
               
               
                   
                 CVSSCCQPFC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 926 
               
               
                   
                 CVSSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 927 
               
               
                   
                 CVSSCCRPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 928 
               
               
                   
                 CVSTCCRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 929 
               
               
                   
                 CVTRCCSTPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 930 
               
               
                   
                 CVTSCCQPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 931 
               
               
                   
                 CVTSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 932 
               
               
                   
                 CVYSCCQPFC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 933 
               
               
                   
                 CVYSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 934 
               
               
                   
                 GCCGCSEGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 935 
               
               
                   
                 GCCGCSGGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 936 
               
               
                   
                 GCCGCSRGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 937 
               
               
                   
                 GCCRPITCCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 938 
               
               
                   
                 GCGSSCCQCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 939 
               
               
                   
                 GCGVPVCCCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 940 
               
               
                   
                 LCCPCQTTCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 941 
               
               
                   
                 PCCCLRPVCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 942 
               
               
                   
                 PCCCRPVTCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 943 
               
               
                   
                 PCCCVRPVCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 944 
               
               
                   
                 PCCSQASCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 945 
               
               
                   
                 PCCSQSRCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 946 
               
               
                   
                 PCCSQSSCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 947 
               
               
                   
                 PCCSQSSCCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 948 
               
               
                   
                 PCCWATTCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 949 
               
               
                   
                 QCSCCKPYCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 950 
               
               
                   
                 RCYVPVCCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 951 
               
               
                   
                 SCCAPVYCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 952 
               
               
                   
                 SCCISSSCCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 953 
               
               
                   
                 SCCVSSCRCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 954 
               
               
                   
                 SCGCSQCSCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 955 
               
               
                   
                 SCGLENCCCP 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 956 
               
               
                   
                 VCCGASSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 957 
               
               
                   
                 VCCGDSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 958 
               
               
                   
                 CASSCCTPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 959 
               
               
                   
                 CCCPSCVVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 960 
               
               
                   
                 CCCPSYCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 961 
               
               
                   
                 CCCSSGCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 962 
               
               
                   
                 CCDTCPPPCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 963 
               
               
                   
                 CCEPHCCALSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 964 
               
               
                   
                 CCEPPCCAPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 965 
               
               
                   
                 CCEPPCCATSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 966 
               
               
                   
                 CCETSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 967 
               
               
                   
                 CCGSSCCGSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 968 
               
               
                   
                 CCGSSCCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 969 
               
               
                   
                 CCHPRCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 970 
               
               
                   
                 CCHPSCCESSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 971 
               
               
                   
                 CCHPSCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 972 
               
               
                   
                 CCHPSCCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 973 
               
               
                   
                 CCHPTCCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 974 
               
               
                   
                 CCHPTCCQTIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 975 
               
               
                   
                 CCISSCCKPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 976 
               
               
                   
                 CCISSCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 977 
               
               
                   
                 CCISSSCCPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 978 
               
               
                   
                 CCKAVCCVPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 979 
               
               
                   
                 CCKPCCSQASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 980 
               
               
                   
                 CCKPCCSQSRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 981 
               
               
                   
                 CCKPCCSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 982 
               
               
                   
                 CCKPCCSSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 983 
               
               
                   
                 CCKPCSCFSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 984 
               
               
                   
                 CCKPCSCSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 985 
               
               
                   
                 CCKPCYCSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 986 
               
               
                   
                 CCKPICCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 987 
               
               
                   
                 CCKPQCCQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 988 
               
               
                   
                 CCKPVCCKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 989 
               
               
                   
                 CCKPYCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 990 
               
               
                   
                 CCKPYCSQCSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 991 
               
               
                   
                 CCMPVCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 992 
               
               
                   
                 CCMPVCCKTVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 993 
               
               
                   
                 CCMSSCCKPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 994 
               
               
                   
                 CCNPCCSQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 995 
               
               
                   
                 CCPGDCFTCCT 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 996 
               
               
                   
                 CCPSCVVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 997 
               
               
                   
                 CCPSYCVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 998 
               
               
                   
                 CCQNTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 999 
               
               
                   
                 CCQPACCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1000 
               
               
                   
                 CCQPCCHPTCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1001 
               
               
                   
                 CCQPCCRPTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1002 
               
               
                   
                 CCQPICGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1003 
               
               
                   
                 CCQPICVTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1004 
               
               
                   
                 CCQPNCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1005 
               
               
                   
                 CCQPSCCETSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1006 
               
               
                   
                 CCQPSCCRPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1007 
               
               
                   
                 CCQPSCCSTPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1008 
               
               
                   
                 CCQPSCCSTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1009 
               
               
                   
                 CCQPSCCVPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1010 
               
               
                   
                 CCQPSCCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1011 
               
               
                   
                 CCQPTCCHPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1012 
               
               
                   
                 CCQPTCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1013 
               
               
                   
                 CCQPTCCRPRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1014 
               
               
                   
                 CCQPTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1015 
               
               
                   
                 CCQPTCCRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1016 
               
               
                   
                 CCQPTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1017 
               
               
                   
                 CCQPTCLSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1018 
               
               
                   
                 CCQPTCLTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1019 
               
               
                   
                 CCQPTCVASCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1020 
               
               
                   
                 CCQPTCVTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1021 
               
               
                   
                 CCQPYCHPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1022 
               
               
                   
                 CCQSMCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1023 
               
               
                   
                 CCQSNCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1024 
               
               
                   
                 CCQSSCCKPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1025 
               
               
                   
                 CCQSSCCKPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1026 
               
               
                   
                 CCQSSCCKPYC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1027 
               
               
                   
                 CCQSSCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1028 
               
               
                   
                 CCQSSCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1029 
               
               
                   
                 CCQSSCFKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1030 
               
               
                   
                 CCQSSCSKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1031 
               
               
                   
                 CCQSSCYKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1032 
               
               
                   
                 CCQSVCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1033 
               
               
                   
                 CCQTICRSTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1034 
               
               
                   
                 CCQTTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1035 
               
               
                   
                 CCQTTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1036 
               
               
                   
                 CCRPACCETTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1037 
               
               
                   
                 CCRPACCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1038 
               
               
                   
                 CCRPLCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1039 
               
               
                   
                 CCRPQCCQSVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1040 
               
               
                   
                 CCRPQCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1041 
               
               
                   
                 CCRPSCCESSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1042 
               
               
                   
                 CCRPSCCETTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1043 
               
               
                   
                 CCRPSCCGSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1044 
               
               
                   
                 CCRPSCCISSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1045 
               
               
                   
                 CCRPSCCKPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1046 
               
               
                   
                 CCRPSCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1047 
               
               
                   
                 CCRPSCCVSRC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1048 
               
               
                   
                 CCRPSCCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1049 
               
               
                   
                 CCRPTCCQNTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1050 
               
               
                   
                 CCRPTCCQTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1051 
               
               
                   
                 CCRPVCCDPCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1052 
               
               
                   
                 CCRTTCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1053 
               
               
                   
                 CCRTTCCRPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1054 
               
               
                   
                 CCRTTCCRTTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1055 
               
               
                   
                 CCSCSSCGSCA 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1056 
               
               
                   
                 CCSPGCQPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1057 
               
               
                   
                 CCSQSSCCKPC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1058 
               
               
                   
                 CCSSGCGSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1059 
               
               
                   
                 CCSSGCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1060 
               
               
                   
                 CCSTPCCQPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1061 
               
               
                   
                 CCVPACSCSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1062 
               
               
                   
                 CCVPACSCTSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1063 
               
               
                   
                 CCVPICCKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1064 
               
               
                   
                 CCVPICCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1065 
               
               
                   
                 CCVPVCCKPIC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1066 
               
               
                   
                 CCVPVCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1067 
               
               
                   
                 CCVPVCCKSNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1068 
               
               
                   
                 CCVPVCCKTVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1069 
               
               
                   
                 CCVPVCCSSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1070 
               
               
                   
                 CCVPVCCVPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1071 
               
               
                   
                 CCVSSCCKPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1072 
               
               
                   
                 CCVSSCCQHSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1073 
               
               
                   
                 CCVSSCCQPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1074 
               
               
                   
                 CCVSSCCRPQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1075 
               
               
                   
                 CCVSTCCRPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1076 
               
               
                   
                 CCVSVCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1077 
               
               
                   
                 CDSSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1078 
               
               
                   
                 CEPCCRPVCCD 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1079 
               
               
                   
                 CFKPCCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1080 
               
               
                   
                 CGDGCCCPSCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1081 
               
               
                   
                 CGGGCCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1082 
               
               
                   
                 CGGSCCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1083 
               
               
                   
                 CGLENCCCPSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1084 
               
               
                   
                 CGQSCCRPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1085 
               
               
                   
                 CGQSCCRPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1086 
               
               
                   
                 CGSCCQSSCCN 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1087 
               
               
                   
                 CGSCGCSQCNC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1088 
               
               
                   
                 CGSCGCSQCSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1089 
               
               
                   
                 CGSGCCGPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1090 
               
               
                   
                 CGSGCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1091 
               
               
                   
                 CGSNCCQPCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1092 
               
               
                   
                 CGSSCCQPCCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1093 
               
               
                   
                 CGSSCCQPCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1094 
               
               
                   
                 CGSSCCQPCYC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1095 
               
               
                   
                 CGSSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1096 
               
               
                   
                 CGSSCCQSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1097 
               
               
                   
                 CGSSCCVPICC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1098 
               
               
                   
                 CGSSCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1099 
               
               
                   
                 CGSSCSQCSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1100 
               
               
                   
                 CGVPVCCCSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1101 
               
               
                   
                 CHPRCCISSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1102 
               
               
                   
                 CHPSCCESSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1103 
               
               
                   
                 CHPSCCISSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1104 
               
               
                   
                 CHPTCCQNTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1105 
               
               
                   
                 CISSCCHPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1106 
               
               
                   
                 CISSCCKPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1107 
               
               
                   
                 CISSCCRPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1108 
               
               
                   
                 CISSSCCPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1109 
               
               
                   
                 CKPCCCSSGCG 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1110 
               
               
                   
                 CKPCCSQASCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1111 
               
               
                   
                 CKPCCSQSRCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1112 
               
               
                   
                 CKPCCSQSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1113 
               
               
                   
                 CKPQCCQSMCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1114 
               
               
                   
                 CKPQCCQSVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1115 
               
               
                   
                 CKPVCCCVPAC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1116 
               
               
                   
                 CKPVCCKPICC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1117 
               
               
                   
                 CKPVCCMPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1118 
               
               
                   
                 CKPVCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1119 
               
               
                   
                 CKPVCCVSVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1120 
               
               
                   
                 CKPYCSQCSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1121 
               
               
                   
                 CLPCCRPTCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1122 
               
               
                   
                 CLTSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1123 
               
               
                   
                 CMSSCCKPQCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1124 
               
               
                   
                 CNPCCSQSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1125 
               
               
                   
                 CPACCVSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1126 
               
               
                   
                 CPESCCEPHCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1127 
               
               
                   
                 CPESCCEPPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1128 
               
               
                   
                 CPSCCESSCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1129 
               
               
                   
                 CPSCCQTTCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1130 
               
               
                   
                 CPSCCVSSCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1131 
               
               
                   
                 CQCSCCKPYCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1132 
               
               
                   
                 CQETCCRPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1133 
               
               
                   
                 CQNTCCRTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1134 
               
               
                   
                 CQPACCTASCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1135 
               
               
                   
                 CQPACCTSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1136 
               
               
                   
                 CQPACCTTSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1137 
               
               
                   
                 CQPACCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1138 
               
               
                   
                 CQPACCVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1139 
               
               
                   
                 CQPCCHPTCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1140 
               
               
                   
                 CQPCCRPACCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1141 
               
               
                   
                 CQPCCRPACCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1142 
               
               
                   
                 CQPCCRPTCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1143 
               
               
                   
                 CQPCYCPACCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1144 
               
               
                   
                 CQPICCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1145 
               
               
                   
                 CQPRCCETSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1146 
               
               
                   
                 CQPSCCETSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1147 
               
               
                   
                 CQPSCCRPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1148 
               
               
                   
                 CQPSCCVPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1149 
               
               
                   
                 CQPSCCVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1150 
               
               
                   
                 CQPTCCCPSYC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1151 
               
               
                   
                 CQPTCCGSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1152 
               
               
                   
                 CQPTCCHPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1153 
               
               
                   
                 CQPTCCQPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1154 
               
               
                   
                 CQPTCCRPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1155 
               
               
                   
                 CQPTCCRPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1156 
               
               
                   
                 CQPTCCRTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1157 
               
               
                   
                 CQQACCMPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1158 
               
               
                   
                 CQQACCVPICC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1159 
               
               
                   
                 CQQACCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1160 
               
               
                   
                 CQQSCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1161 
               
               
                   
                 CQQSCCVSVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1162 
               
               
                   
                 CQSNCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1163 
               
               
                   
                 CQSSCCCPASC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1164 
               
               
                   
                 CQSSCCKPCCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1165 
               
               
                   
                 CQSSCCKPCSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1166 
               
               
                   
                 CQSSCCKPYCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1167 
               
               
                   
                 CQSSCCNPCCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1168 
               
               
                   
                 CQSSCCQSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1169 
               
               
                   
                 CQSSCCVPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1170 
               
               
                   
                 CQSSCFKPCCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1171 
               
               
                   
                 CQSSCSKPCCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1172 
               
               
                   
                 CQSSCYKPCCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1173 
               
               
                   
                 CQSVCCQPTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1174 
               
               
                   
                 CQTTCCCPSCV 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1175 
               
               
                   
                 CQTTCCRPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1176 
               
               
                   
                 CQTTCCRTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1177 
               
               
                   
                 CRPACCETTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1178 
               
               
                   
                 CRPACCQNTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1179 
               
               
                   
                 CRPCCCLRPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1180 
               
               
                   
                 CRPCCCVRPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1181 
               
               
                   
                 CRPCCWATTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1182 
               
               
                   
                 CRPLCCQTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1183 
               
               
                   
                 CRPQCCQSVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1184 
               
               
                   
                 CRPQCCQTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1185 
               
               
                   
                 CRPRCCISSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1186 
               
               
                   
                 CRPSCCESSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1187 
               
               
                   
                 CRPSCCISSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1188 
               
               
                   
                 CRPSCCKPQCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1189 
               
               
                   
                 CRPSCCPSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1190 
               
               
                   
                 CRPSCCQTTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1191 
               
               
                   
                 CRPSCCRPQCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1192 
               
               
                   
                 CRPSCCVSRCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1193 
               
               
                   
                 CRPSCCVSSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1194 
               
               
                   
                 CRPTCCQNTCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1195 
               
               
                   
                 CRPVCCCEPTC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1196 
               
               
                   
                 CRPVCCCYSCE 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1197 
               
               
                   
                 CRTTCCHPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1198 
               
               
                   
                 CRTTCCRPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1199 
               
               
                   
                 CSCCKPYCSQC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1200 
               
               
                   
                 CSKPCCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1201 
               
               
                   
                 CSPCCQPTCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1202 
               
               
                   
                 CSPCCVSSCCQ 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1203 
               
               
                   
                 CSQCSCCKPCY 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1204 
               
               
                   
                 CSQCSCYKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1205 
               
               
                   
                 CSQSNCCKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1206 
               
               
                   
                 CSQSSCCKPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1207 
               
               
                   
                 CSSSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1208 
               
               
                   
                 CTPSCCQPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1209 
               
               
                   
                 CVASCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1210 
               
               
                   
                 CVPICCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1211 
               
               
                   
                 CVPSCCQPCCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1212 
               
               
                   
                 CVPVCCCKPMC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1213 
               
               
                   
                 CVPVCCCKPVC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1214 
               
               
                   
                 CVPVCCKPVCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1215 
               
               
                   
                 CVSSCCKPQCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1216 
               
               
                   
                 CVSSCCQHSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1217 
               
               
                   
                 CVSSCCQPCCH 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1218 
               
               
                   
                 CVSSCCQPCCR 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1219 
               
               
                   
                 CVSSCCQPFCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1220 
               
               
                   
                 CVSSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1221 
               
               
                   
                 CVSSCCRPQCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1222 
               
               
                   
                 CVTRCCSTPCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1223 
               
               
                   
                 CVTSCCQPACC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1224 
               
               
                   
                 CVTSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1225 
               
               
                   
                 CVYSCCQPFCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1226 
               
               
                   
                 CVYSCCQPSCC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1227 
               
               
                   
                 CYCPACCVSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1228 
               
               
                   
                 CYKPCCCQSSC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1229 
               
               
                   
                 CYKPCCCSSGC 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1230 
               
               
                   
                 MCCCVPACSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1231 
               
               
                   
                 NCCVPVCCQCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1232 
               
               
                   
                 QCSCCKPCYCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1233 
               
               
                   
                 QCSCYKPCCCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1234 
               
               
                   
                 SCCVPICCQCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1235 
               
               
                   
                 SCCVPVCCQCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1236 
               
               
                   
                 SCGCSQCNCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1237 
               
               
                   
                 SCGCSQCSCCK 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1238 
               
               
                   
                 VCCCVPACSCS 
               
               
                   
                   
               
               
                   
                 SEQ.ID NO: 1239 
               
               
                   
                 VCCCVPACSCT 
               
               
                   
                   
               
             
          
         
       
     
         [0124]    The present invention is of course in any way restricted to the embodiments herein described and one with ordinary skill in the area can provide many possibilities to modifications and substitutions of technical characteristics by equivalent ones, depending on each situation, as defined in the claims. 
         [0125]    The preferred embodiments described above may obviously be combined. The following claims define further preferred embodiments.