prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Idh3g in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Idh3g
|
phagocytosis
|
Microglial Cell Line
|
Gene: Idh3g (isocitrate dehydrogenase 3 (NAD+), gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: ATP binding, NAD binding, enzyme activator activity, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding, metal ion binding, nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: isocitrate dehydrogenase complex (NAD+), mitochondrion, nucleolus, photoreceptor inner segment
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, TCA cycle variation III (eukaryotic)
UniProt: P70404
Entrez ID: 15929
|
Does Knockout of Ptdss1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Ptdss1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ptdss1 (phosphatidylserine synthase 1)
Type: protein-coding
Summary: Enables L-serine-phosphatidylcholine phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, phosphatidylserine biosynthetic process, phospholipid biosynthetic process; MF: L-serine-phosphatidylcholine phosphatidyltransferase activity, L-serine-phosphatidylethanolamine phosphatidyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PS, phosphatidylethanolamine biosynthesis I, phospholipid biosynthesis I
UniProt: Q99LH2
Entrez ID: 19210
|
Does Knockout of Brsk1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Brsk1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Brsk1 (BR serine/threonine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G2/M transition of mitotic cell cycle, associative learning, axonogenesis, central nervous system neuron differentiation, centrosome duplication, establishment of cell polarity, microtubule cytoskeleton organization involved in establishment of planar polarity, mitotic G2 DNA damage checkpoint signaling, nervous system development, neuron projection morphogenesis, neurotransmitter secretion, protein phosphorylation, regulation of axonogenesis, regulation of neuron projection development, regulation of synaptic plasticity, regulation of synaptic vesicle priming, response to UV, synaptic vesicle cycle; MF: ATP binding, gamma-tubulin binding, kinase activity, magnesium ion binding, metal ion binding, molecular function inhibitor activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity, transferase activity; CC: cell junction, cell projection, centrosome, cholinergic synapse, cytoplasm, cytoplasmic vesicle, cytoskeleton, distal axon, nucleoplasm, nucleus, postsynaptic density, presynaptic active zone, synapse, synaptic vesicle
Pathways:
UniProt: Q5RJI5
Entrez ID: 381979
|
Does Knockout of Zfp729b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Zfp729b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfp729b (zinc finger protein 729b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A0A0J9YSF5, Q80VN4
Entrez ID: 100416706
|
Does Knockout of Cdkl5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cdkl5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cdkl5 (cyclin dependent kinase like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modulation of chemical synaptic transmission, neuron migration, positive regulation of Rac protein signal transduction, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of dendritic spine development, protein localization to nucleus, regulation of cell cycle, regulation of cilium assembly, regulation of dendrite development, regulation of postsynapse organization; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity; CC: cell projection, centrosome, ciliary basal body, ciliary tip, cytoplasm, cytoskeleton, dendrite cytoplasm, dendritic growth cone, glutamatergic synapse, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynaptic density, intracellular component, ruffle membrane
Pathways:
UniProt: Q3UTQ8
Entrez ID: 382253
|
Does Knockout of Ercc6l2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ercc6l2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ercc6l2 (excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to reactive oxygen species, double-strand break repair via classical nonhomologous end joining, interstrand cross-link repair; MF: ATP binding, DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein kinase binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, mitochondrion, nucleus, protein-containing complex
Pathways:
UniProt: Q9JIM3
Entrez ID: 76251
|
Does Knockout of Pgrmc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Pgrmc1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pgrmc1 (progesterone receptor membrane component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, axon guidance, heme biosynthetic process, memory, modification of synaptic structure, negative regulation of synapse organization, positive regulation of lipoprotein transport, positive regulation of protein localization to plasma membrane; MF: heme binding, lipid binding, metal ion binding, protein binding, protein homodimerization activity, steroid binding; CC: cell body, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, membrane, mitochondrial outer membrane, mitochondrion, neuron projection, neuronal cell body, synapse
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: O55022
Entrez ID: 53328
|
Does Knockout of Rsad1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rsad1
|
response to virus
|
Microglial Cell Line
|
Gene: Rsad1 (radical S-adenosyl methionine domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: porphyrin-containing compound biosynthetic process; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, coproporphyrinogen oxidase activity, heme binding, iron-sulfur cluster binding, metal ion binding; CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q5SUV1
Entrez ID: 237926
|
Does Knockout of Mir702 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir702
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir702 (microRNA 702)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: negative regulation of gene expression, positive regulation of stem cell proliferation
Pathways:
UniProt:
Entrez ID: 735283
|
Does Knockout of Rabep2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rabep2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rabep2 (rabaptin, RAB GTPase binding effector protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, endocytosis, protein transport, regulation of cilium assembly, signal transduction; MF: GTPase activator activity, growth factor activity; CC: Golgi apparatus, cell projection, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, early endosome, endosome, intracellular membrane-bounded organelle
Pathways: cyclic AMP biosynthesis
UniProt: Q91WG2
Entrez ID: 70314
|
Does Knockout of Pacsin3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Pacsin3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Pacsin3 (protein kinase C and casein kinase substrate in neurons 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, endocytosis, negative regulation of calcium ion transport, negative regulation of endocytosis, plasma membrane tubulation, positive regulation of membrane protein ectodomain proteolysis, regulation of endocytosis; MF: calcium channel inhibitor activity, cytoskeletal protein binding, identical protein binding, lipid binding, phospholipid binding, protein binding; CC: cytoplasm, cytosol, endosome, membrane, plasma membrane
Pathways: Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q99JB8
Entrez ID: 80708
|
Does Knockout of Itga3 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Itga3
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Itga3 (integrin alpha 3)
Type: protein-coding
Summary: This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cell adhesion, cell differentiation, cell-cell adhesion, cell-matrix adhesion, dendritic spine maintenance, exploration behavior, heart development, integrin-mediated signaling pathway, leukocyte migration, lung development, maternal process involved in female pregnancy, memory, mesodermal cell differentiation, negative regulation of Rho protein signal transduction, negative regulation of cell projection organization, nephron development, neuron migration, positive regulation of cell-substrate adhesion, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of neuron projection development, positive regulation of protein localization to plasma membrane, postsynapse organization, regulation of BMP signaling pathway, regulation of Wnt signaling pathway, regulation of signal transduction, regulation of transforming growth factor beta receptor signaling pathway, renal filtration, response to gonadotropin, response to xenobiotic stimulus, skin development, synaptic membrane adhesion, system development, system process; MF: collagen binding, fibronectin binding, integrin binding, laminin binding, protease binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding, signaling receptor activity; CC: anchoring junction, basolateral plasma membrane, cell periphery, cell projection, cell surface, excitatory synapse, external side of plasma membrane, filopodium membrane, glutamatergic synapse, growth cone, growth cone filopodium, integrin alpha3-beta1 complex, integrin complex, membrane, neuromuscular junction, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, presynaptic active zone membrane, receptor complex, synapse, synaptic membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Basigin interactions, Cell surface interactions at the vascular wall, Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, MET activates PTK2 signaling, MET promotes cell motility, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse)
UniProt: Q62470
Entrez ID: 16400
|
Does Knockout of 2900026A02Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
2900026A02Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 2900026A02Rik (RIKEN cDNA 2900026A02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cilium, intercellular bridge, microtubule cytoskeleton
Pathways:
UniProt: Q8BRV5
Entrez ID: 243219
|
Does Knockout of Fau in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Fau
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fau (FAU ubiquitin like and ribosomal protein S30 fusion)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-positive bacterium, innate immune response in mucosa, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit assembly, translation; MF: protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular space, nucleus, ribonucleoprotein complex, ribosome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62862
Entrez ID: 14109
|
Does Knockout of Pcdha1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Pcdha1
|
cell cycle progression
|
breast epithelium
|
Gene: Pcdha1 (protocadherin alpha 1)
Type: protein-coding
Summary: Predicted to be involved in cell adhesion. Located in endoplasmic reticulum and membrane. Is expressed in brain; cerebral cortex; enteric nervous system; and intestine. Orthologous to human PCDHA1 (protocadherin alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways:
UniProt: Q641K6, Q91Y21
Entrez ID: 116731
|
Does Knockout of Fkbp14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Fkbp14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fkbp14 (FK506 binding protein 14)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity; and calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: calcium ion binding, isomerase activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: P59024
Entrez ID: 231997
|
Does Knockout of Dhrs13 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Dhrs13
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dhrs13 (dehydrogenase/reductase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SS80
Entrez ID: 70451
|
Does Knockout of Itga8 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Itga8
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Itga8 (integrin alpha 8)
Type: protein-coding
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: cell adhesion, cell differentiation, cell projection organization, cell-cell adhesion, cell-matrix adhesion, embryonic morphogenesis, establishment of protein localization, extracellular matrix organization, inner ear morphogenesis, integrin-mediated signaling pathway, kidney development, memory, mesodermal cell differentiation, metanephros development, nervous system development, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, smooth muscle cell differentiation, smooth muscle tissue development, substrate adhesion-dependent cell spreading, tissue development; MF: metal ion binding, signaling receptor activity; CC: apical part of cell, cell surface, dendritic spine membrane, endoplasmic reticulum, focal adhesion, glutamatergic synapse, integrin complex, membrane, perikaryon, plasma membrane, postsynaptic density membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, Molecules associated with elastic fibres, PI3K-Akt signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs
UniProt: A2ARA8
Entrez ID: 241226
|
Does Knockout of Klhl32 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Klhl32
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Klhl32 (kelch-like 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJX0, E9Q7Q2, J3QPI3, J3KML3, A2AJX1
Entrez ID: 212390
|
Does Knockout of Vmn1r200 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Vmn1r200
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r200 (vomeronasal 1 receptor 200)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQ12, Q8R281
Entrez ID: 171246
|
Does Knockout of Mob3b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mob3b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mob3b (MOB kinase activator 3B)
Type: protein-coding
Summary: Predicted to enable protein kinase activator activity. Predicted to be involved in regulation of hippo signaling and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; lower jaw incisor; lower jaw molar; upper jaw incisor; and upper jaw molar. Orthologous to human MOB3B (MOB kinase activator 3B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of hippo signaling, signal transduction; MF: metal ion binding, protein kinase activator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8VE04
Entrez ID: 214944
|
Does Knockout of Vim in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Vim
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vim (vimentin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Bergmann glial cell differentiation, astrocyte development, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to type II interferon, cytoskeleton organization, intermediate filament organization, intermediate filament-based process, lens fiber cell development, negative regulation of neuron projection development, positive regulation of collagen biosynthetic process, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of glial cell proliferation, regulation of Schwann cell migration, regulation of axonogenesis, regulation of mRNA stability; MF: RNA binding, double-stranded RNA binding, identical protein binding, keratin filament binding, kinase binding, molecular adaptor activity, protein binding, protein domain specific binding, protein phosphatase 2A binding, protein tyrosine kinase binding, scaffold protein binding, structural constituent of cytoskeleton, structural constituent of eye lens; CC: axon, cell body, cell leading edge, cell projection, cytoplasm, cytoskeleton, cytosol, intermediate filament, intermediate filament cytoskeleton, membrane, neuron projection, nuclear matrix, nucleus, perinuclear region of cytoplasm, peroxisome, phagocytic vesicle, plasma membrane, supramolecular fiber, type III intermediate filament
Pathways: Aggrephagy, Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Autophagy, Caspase-mediated cleavage of cytoskeletal proteins, Epstein-Barr virus infection - Mus musculus (mouse), Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), Muscle contraction, Programmed Cell Death, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Striated Muscle Contraction
UniProt: P20152
Entrez ID: 22352
|
Does Knockout of Creb3l2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Creb3l2
|
cell proliferation
|
Regulatory T cell
|
Gene: Creb3l2 (cAMP responsive element binding protein 3-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, chondrocyte differentiation, endoplasmic reticulum to Golgi vesicle-mediated transport, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to unfolded protein; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, transcription cis-regulatory region binding; CC: Golgi membrane, chromatin, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus, perinuclear endoplasmic reticulum
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8BH52
Entrez ID: 208647
|
Does Knockout of Lsm1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Lsm1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity and pre-mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Located in P-body. Is expressed in central nervous system; heart; metanephros; and submandibular gland. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA processing, negative regulation of neuron differentiation, nuclear-transcribed mRNA catabolic process, stem cell population maintenance; MF: RNA binding, mRNA binding, pre-mRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, P-body, axon, cytoplasm, dendrite, neuronal cell body, nucleus, ribonucleoprotein complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8VC85
Entrez ID: 67207
|
Does Knockout of Nvl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Nvl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nvl (nuclear VCP-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein binding, positive regulation of telomere maintenance, rRNA processing, regulation of protein localization to nucleolus, ribosomal large subunit biogenesis, ribosome biogenesis, telomerase holoenzyme complex assembly; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, preribosome binding; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DBY8
Entrez ID: 67459
|
Does Knockout of Tff1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tff1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tff1 (trefoil factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, maintenance of gastrointestinal epithelium, negative regulation of cell population proliferation, response to wounding, signal transduction; MF: growth factor activity, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Estrogen signaling pathway - Mus musculus (mouse)
UniProt: Q08423
Entrez ID: 21784
|
Does Knockout of Acvr1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Acvr1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Acvr1 (activin A receptor, type 1)
Type: protein-coding
Summary: Enables activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including BMP signaling pathway; heart development; and positive regulation of SMAD protein signal transduction. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and gastrulation. Located in apical part of cell and plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; male reproductive gland or organ; and sensory organ. Used to study fibrodysplasia ossificans progressiva. Human ortholog(s) of this gene implicated in exfoliation syndrome; fibrodysplasia ossificans progressiva; primary angle-closure glaucoma; and primary open angle glaucoma. Orthologous to human ACVR1 (activin A receptor type 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: BMP signaling pathway, activin receptor signaling pathway, acute inflammatory response, atrial septum primum morphogenesis, atrioventricular valve morphogenesis, branching involved in blood vessel morphogenesis, cardiac muscle cell fate commitment, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, determination of left/right symmetry, dorsal/ventral pattern formation, embryonic heart tube morphogenesis, endocardial cushion cell fate commitment, endocardial cushion formation, endocardial cushion fusion, endocardial cushion morphogenesis, gastrulation, gastrulation with mouth forming second, germ cell development, heart development, in utero embryonic development, mesoderm development, mesoderm formation, mitral valve morphogenesis, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of activin receptor signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of signal transduction, neural crest cell migration, osteoblast differentiation, outflow tract septum morphogenesis, pharyngeal system development, positive regulation of DNA-templated transcription, positive regulation of SMAD protein signal transduction, positive regulation of bone mineralization, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cell migration, positive regulation of determination of dorsal identity, positive regulation of intracellular signal transduction, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, regulation of developmental process, regulation of ossification, smooth muscle cell differentiation, transforming growth factor beta receptor signaling pathway, urogenital system development, ventricular septum morphogenesis; MF: ATP binding, BMP receptor activity, SMAD binding, activin binding, activin receptor activity, type I, cadherin binding, growth factor binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase binding, transferase activity, transforming growth factor beta binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity; CC: BMP receptor complex, activin receptor complex, apical part of cell, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P37172
Entrez ID: 11477
|
Does Knockout of Ghdc in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ghdc
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ghdc (GH3 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, endoplasmic reticulum, nuclear envelope, nucleus
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99J23
Entrez ID: 80860
|
Does Knockout of Kmt2d in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Kmt2d
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Kmt2d (lysine (K)-specific methyltransferase 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, developmental growth, heterochromatin formation, in utero embryonic development, methylation, oocyte growth, oogenesis, positive regulation of cell population proliferation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to estrogen; MF: DNA-binding transcription activator activity, RNA polymerase II-specific, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL3/4 complex, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse)
UniProt: Q6PDK2
Entrez ID: 381022
|
Does Knockout of Smarcc1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Smarcc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Smarcc1 (SWI/SNF related BAF chromatin remodeling complex subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, chromatin organization, chromatin remodeling, chromosome organization, insulin receptor signaling pathway, negative regulation of cell differentiation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, nervous system development, nucleosome disassembly, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, prostate gland development, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: chromatin binding, histone binding, protein binding; CC: GBAF complex, RSC-type complex, SWI/SNF complex, XY body, brahma complex, chromatin, cytoplasm, kinetochore, male germ cell nucleus, nBAF complex, npBAF complex, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: P97496
Entrez ID: 20588
|
Does Knockout of Abi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Abi2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Abi2 (abl interactor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, camera-type eye development, cell migration, cell projection morphogenesis, dendrite development, learning or memory, lens fiber cell morphogenesis, mitophagy, nervous system development, neuron migration, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of lamellipodium assembly, postsynapse organization, postsynaptic actin cytoskeleton organization, regulation of dendritic spine morphogenesis, zonula adherens assembly; MF: identical protein binding, signaling adaptor activity, small GTPase binding, ubiquitin protein ligase binding; CC: SCAR complex, actin filament, actin-based cell projection, adherens junction, anchoring junction, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, filopodium, filopodium tip, glutamatergic synapse, lamellipodium, postsynaptic actin cytoskeleton, synapse
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P62484
Entrez ID: 329165
|
Does Knockout of 1700008O03Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
1700008O03Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: 1700008O03Rik (RIKEN cDNA 1700008O03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z070
Entrez ID: 69349
|
Does Knockout of Gtf2e2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Gtf2e2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TFIIH-class transcription factor complex binding, protein binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q9D902
Entrez ID: 68153
|
Does Knockout of Tsc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Tsc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tsc1 (TSC complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, TORC1 signaling, adaptive immune response, adult locomotory behavior, associative learning, cardiac muscle cell differentiation, cell projection organization, cell-matrix adhesion, cellular response to decreased oxygen levels, cellular response to starvation, cerebral cortex development, hippocampus development, kidney development, memory T cell differentiation, myelination, negative regulation of ATP-dependent activity, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of cellular response to oxidative stress, negative regulation of macroautophagy, negative regulation of neuron projection development, nervous system development, neural tube closure, positive regulation of TORC1 signaling, positive regulation of focal adhesion assembly, positive regulation of macroautophagy, positive regulation of stress fiber assembly, potassium ion transport, protein folding, protein stabilization, regulation of cell cycle, regulation of cell-matrix adhesion, regulation of focal adhesion assembly, regulation of stress fiber assembly, response to insulin, synapse organization; MF: ATPase inhibitor activity, Hsp70 protein binding, Hsp90 protein binding, protein binding, protein folding chaperone, protein-folding chaperone binding; CC: TSC1-TSC2 complex, actin filament, cell cortex, cell projection, ciliary basal body, cytoplasm, cytosol, growth cone, lamellipodium, lipid droplet, lysosomal membrane, lysosome, membrane, nucleus, perinuclear region of cytoplasm, postsynaptic density, protein folding chaperone complex, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inhibition of TSC complex formation by PKB, Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, Macroautophagy, Membrane Trafficking, PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Rab regulation of trafficking, Signal Transduction, TBC/RABGAPs, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9EP53
Entrez ID: 64930
|
Does Knockout of Nr4a3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Nr4a3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3)
Type: protein-coding
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: adult behavior, axon guidance, cellular respiration, cellular response to catecholamine stimulus, cellular response to corticotropin-releasing hormone stimulus, cellular response to leptin stimulus, common myeloid progenitor cell proliferation, energy homeostasis, fat cell differentiation, gastrulation, hippocampus development, inner ear morphogenesis, intracellular receptor signaling pathway, intracellular signal transduction, mast cell degranulation, mesoderm formation, negative regulation of neuron apoptotic process, negative regulation of smooth muscle cell apoptotic process, negative regulation of transcription by RNA polymerase II, neuromuscular process controlling balance, platelet-derived growth factor receptor signaling pathway, positive regulation of D-glucose transmembrane transport, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle hypertrophy, positive regulation of cell cycle, positive regulation of dendritic cell apoptotic process, positive regulation of epithelial cell proliferation, positive regulation of feeding behavior, positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway, positive regulation of mast cell cytokine production, positive regulation of monocyte aggregation, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of smooth muscle cell proliferation, regulation of transcription by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to hydrogen peroxide, semicircular canal morphogenesis, vestibular reflex; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, double-stranded DNA binding, histone acetyltransferase binding, metal ion binding, nuclear glucocorticoid receptor binding, nuclear receptor activity, protein homodimerization activity, protein kinase binding, sequence-specific DNA binding, transcription coactivator binding, zinc ion binding; CC: nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QZB6
Entrez ID: 18124
|
Does Knockout of Nfyc in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Nfyc
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Nfyc (nuclear transcription factor-Y gamma)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, transcription cis-regulatory region binding; CC: CCAAT-binding factor complex, RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P70353
Entrez ID: 18046
|
Does Knockout of Krt78 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Krt78
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Krt78 (keratin 78)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; CC: cornified envelope, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q6IFT3, E9Q0F0
Entrez ID: 332131
|
Does Knockout of Gm9887 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,266
|
Knockout
|
Gm9887
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm9887 (predicted gene 9887)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nlgn1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Nlgn1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nlgn1 (neuroligin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMPA glutamate receptor clustering, AMPA selective glutamate receptor signaling pathway, NMDA glutamate receptor clustering, NMDA selective glutamate receptor signaling pathway, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell-cell adhesion involved in synapse maturation, cellular response to calcium ion, cytoskeletal matrix organization at active zone, establishment of protein localization, excitatory synapse assembly, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inhibitory postsynaptic potential, long-term synaptic potentiation, maintenance of synapse structure, membrane assembly, modulation of chemical synaptic transmission, negative regulation of dendritic spine morphogenesis, nervous system development, neurexin clustering involved in presynaptic membrane assembly, neuron cell-cell adhesion, neuron projection arborization, neuron projection development, neuron projection morphogenesis, positive regulation of circadian sleep/wake cycle, wakefulness, positive regulation of dendritic spine development, positive regulation of excitatory postsynaptic potential, positive regulation of filopodium assembly, positive regulation of intracellular signal transduction, positive regulation of multicellular organismal process, positive regulation of neuromuscular synaptic transmission, positive regulation of neuron projection development, positive regulation of presynaptic active zone assembly, positive regulation of protein localization to synapse, positive regulation of ruffle assembly, positive regulation of synapse assembly, positive regulation of synaptic transmission, GABAergic, positive regulation of synaptic transmission, glutamatergic, positive regulation of synaptic vesicle clustering, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle exocytosis, postsynaptic density protein 95 clustering, postsynaptic membrane assembly, postsynaptic specialization assembly, presynaptic membrane assembly, protein localization to synapse, protein targeting, receptor localization to synapse, regulation of membrane potential, regulation of nervous system process, regulation of neuron differentiation, regulation of postsynaptic density assembly, regulation of presynapse organization, regulation of respiratory gaseous exchange by nervous system process, regulation of signal transduction, rhythmic process, synapse assembly, synapse maturation, synapse organization, synaptic membrane adhesion, synaptic vesicle clustering, synaptic vesicle targeting, synaptic vesicle transport, terminal button organization; MF: PDZ domain binding, cell adhesion mediator activity, cell adhesion molecule binding, identical protein binding, neurexin family protein binding, protein binding, protein-containing complex binding, scaffold protein binding, signaling receptor activity; CC: Golgi apparatus, cell surface, dendrite, dendritic shaft, dendritic spine, excitatory synapse, external side of plasma membrane, extracellular region, filopodium tip, glutamatergic synapse, membrane, neuromuscular junction, neuron to neuron synapse, plasma membrane, postsynaptic density, postsynaptic specialization membrane, presynapse, protein complex involved in cell-cell adhesion, receptor complex, synapse, synaptic cleft, synaptic membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse), Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q99K10
Entrez ID: 192167
|
Does Knockout of Tmem231 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tmem231
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem231 (transmembrane protein 231)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, cell projection organization, cilium assembly, embryonic digit morphogenesis, in utero embryonic development, neuroepithelial cell differentiation, regulation of protein localization, smoothened signaling pathway, vasculature development; CC: MKS complex, cell projection, ciliary membrane, ciliary transition zone, cilium, membrane, plasma membrane
Pathways:
UniProt: Q3U284
Entrez ID: 234740
|
Does Knockout of Prkcsh in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Prkcsh
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Prkcsh (protein kinase C substrate 80K-H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-glycan processing, in utero embryonic development, liver development, negative regulation of neuron projection development, nitrogen cycle metabolic process; MF: RNA binding, calcium ion binding, metal ion binding, phosphoprotein binding, protein binding, protein kinase C binding, protein-containing complex binding, transmembrane transporter binding; CC: endoplasmic reticulum, glucosidase II complex, intracellular membrane-bounded organelle
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: O08795
Entrez ID: 19089
|
Does Knockout of Hsd17b12 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Hsd17b12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic process, positive regulation of cell-substrate adhesion, steroid biosynthetic process; MF: collagen binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, fibronectin binding, heparin binding, oxidoreductase activity, very-long-chain 3-oxoacyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, fatty acid elongase complex, membrane
Pathways: Androgen biosynthesis, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, biosynthesis of estrogens
UniProt: O70503
Entrez ID: 56348
|
Does Knockout of Adamts20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Adamts20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Adamts20 (ADAM metallopeptidase with thrombospondin type 1 motif 20)
Type: protein-coding
Summary: This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a 'belted' phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: extracellular matrix organization, negative regulation of apoptotic process, positive regulation of melanocyte differentiation, positive regulation of signal transduction, proteolysis, regulation of developmental pigmentation; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: P59511
Entrez ID: 223838
|
Does Knockout of Ubxn2a in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ubxn2a
|
response to virus
|
Microglial Cell Line
|
Gene: Ubxn2a (UBX domain protein 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, autophagosome assembly, cellular response to leukemia inhibitory factor, membrane fusion, negative regulation of ERAD pathway, negative regulation of proteolysis, nuclear membrane reassembly, positive regulation of protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of gene expression, regulation of macromolecule metabolic process, regulation of protein catabolic process, regulation of protein ubiquitination; MF: acetylcholine receptor binding, ubiquitin binding; CC: Golgi apparatus, cell projection, cis-Golgi network, cytoplasm, cytosol, dendrite, endoplasmic reticulum, nucleus, perikaryon
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q99KJ0
Entrez ID: 217379
|
Does Knockout of Ago4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ago4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ago4 (argonaute RISC catalytic subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, mRNA catabolic process, male gonad development, male meiotic nuclear division, miRNA metabolic process, miRNA processing, miRNA-mediated gene silencing by inhibition of translation, negative regulation of apoptotic process, pre-miRNA processing, regulation of cell morphogenesis, regulation of translation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, synaptonemal complex assembly; MF: RNA binding, RNA endonuclease activity, double-stranded RNA binding, miRNA binding, nucleic acid binding, single-stranded RNA binding; CC: P-body, RISC complex, RISC-loading complex, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, nucleus, ribonucleoprotein complex
Pathways: Gene Silencing by RNA, Gene expression (Transcription), MicroRNA (miRNA) biogenesis, Post-transcriptional silencing by small RNAs, Small interfering RNA (siRNA) biogenesis
UniProt: Q8CJF8
Entrez ID: 76850
|
Does Knockout of F13b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
F13b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: F13b (coagulation factor XIII, beta subunit)
Type: protein-coding
Summary: This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in the plasma. During the blood coagulation process, thrombin-mediated proteolytic cleavage of the subunit A results in the dissociation of the encoded protein from the heterotetramer. Male mice lacking the encoded protein exhibit mild fibrosis together with hemosiderin deposits in the heart. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: blood coagulation, blood coagulation, fibrin clot formation, hemostasis; CC: cellular_component, extracellular region
Pathways: Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Formation of Fibrin Clot (Clotting Cascade), Hemostasis
UniProt: Q07968
Entrez ID: 14060
|
Does Knockout of Lrit3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Lrit3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lrit3 (leucine-rich repeat, immunoglobulin-like and transmembrane domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, intracellular protein localization, regulation of fibroblast growth factor receptor signaling pathway, response to light stimulus, synapse assembly involved in innervation, synaptic signaling, visual perception; MF: molecular_function, protein binding; CC: cell projection, cell tip, cellular_component, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perikaryon, synapse
Pathways:
UniProt: W8DXL4
Entrez ID: 242235
|
Does Knockout of Sgcd in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Sgcd
|
cell cycle progression
|
breast epithelium
|
Gene: Sgcd (sarcoglycan, delta (dystrophin-associated glycoprotein))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, calcium-mediated signaling, cardiac muscle cell contraction, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, coronary vasculature morphogenesis, heart contraction, heart process, membrane organization, protein-containing complex localization; CC: cytoplasm, cytoskeleton, dystroglycan complex, dystrophin-associated glycoprotein complex, membrane, plasma membrane, sarcoglycan complex, sarcolemma, sarcoplasmic reticulum
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Non-integrin membrane-ECM interactions, Viral myocarditis - Mus musculus (mouse)
UniProt: P82347
Entrez ID: 24052
|
Does Knockout of Bpifa5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Bpifa5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Bpifa5 (BPI fold containing family A, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, immune response in nasopharyngeal-associated lymphoid tissue, innate immune response, multicellular organismal-level water homeostasis, negative regulation of single-species biofilm formation in or on host organism, regulation of sodium ion transmembrane transport, surfactant homeostasis; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9CQX3
Entrez ID: 67135
|
Does Knockout of Gsdmcl2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gsdmcl2
|
phagocytosis
|
macrophage
|
Gene: Gsdmcl2 (gasdermin C-like 2)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Extl1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Extl1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Extl1 (exostosin-like glycosyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process, protein glycosylation; MF: acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q9JKV7
Entrez ID: 56219
|
Does Knockout of Glmn in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 617
|
Knockout
|
Glmn
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Glmn (glomulin, FKBP associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, circulatory system development, epigenetic regulation of gene expression, muscle cell differentiation, negative regulation of T cell proliferation, negative regulation of cell population proliferation, neural tube closure, positive regulation of cytokine production, positive regulation of interleukin-2 production, positive regulation of phosphorylation, regulation of proteasomal ubiquitin-dependent protein catabolic process, vasculogenesis; MF: hepatocyte growth factor receptor binding, protein binding, signaling receptor binding, ubiquitin protein ligase binding, ubiquitin-protein transferase inhibitor activity; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8BZM1
Entrez ID: 170823
|
Does Knockout of Mycbp in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mycbp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mycbp (MYC binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9EQS3
Entrez ID: 56309
|
Does Knockout of Tnfrsf22 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Tnfrsf22
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tnfrsf22 (tumor necrosis factor receptor superfamily, member 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAIL-activated apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of apoptotic process; MF: TRAIL binding, protein binding; CC: cell surface, external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q9ER62
Entrez ID: 79202
|
Does Knockout of Foxn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Foxn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Foxn1 (forkhead box N1)
Type: protein-coding
Summary: The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: T cell homeostasis, T cell lineage commitment, blood vessel morphogenesis, cell differentiation, epidermis development, hair follicle development, hemopoiesis, keratinocyte differentiation, lymphocyte homeostasis, lymphoid lineage cell migration into thymus, nail development, positive regulation of epithelial cell differentiation, positive regulation of hair follicle development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of T cell differentiation in thymus, regulation of gene expression, regulation of positive thymic T cell selection, regulation of transcription by RNA polymerase II, thymus development, thymus epithelium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding, transcription cis-regulatory region binding
Pathways:
UniProt: Q61575
Entrez ID: 15218
|
Does Knockout of Capza1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Capza1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Capza1 (capping actin protein of muscle Z-line subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, barbed-end actin filament capping, cell junction assembly; MF: actin binding, actin filament binding, protein binding; CC: F-actin capping protein complex, WASH complex, brush border, cell-cell junction, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: A0A0G2JE27, Q5RKN9
Entrez ID: 12340
|
Does Knockout of Pip5k1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pip5k1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pip5k1a (phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Located in cytosol; nucleus; and ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin cytoskeleton organization, activation of GTPase activity, cell chemotaxis, fibroblast migration, focal adhesion assembly, lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, phospholipid biosynthetic process, protein localization to plasma membrane, ruffle assembly; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, kinase activity, kinase binding, nucleotide binding, phosphatidylinositol kinase activity, protein binding, transferase activity; CC: cell projection, cytoplasm, cytosol, lamellipodium, mRNA cleavage and polyadenylation specificity factor complex, membrane, nuclear speck, nucleoplasm, nucleus, plasma membrane, ruffle, ruffle membrane
Pathways: 3-phosphoinositide biosynthesis, Choline metabolism in cancer - Mus musculus (mouse), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Inositol phosphate metabolism - Mus musculus (mouse), Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Synthesis of PIPs at the plasma membrane, Yersinia infection - Mus musculus (mouse)
UniProt: P70182
Entrez ID: 18720
|
Does Knockout of Sult1c2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Sult1c2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Sult1c2 (sulfotransferase family, cytosolic, 1C, member 2)
Type: protein-coding
Summary: Enables aryl sulfotransferase activity. Involved in sulfation. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Is expressed in central nervous system; sensory organ; and skeleton. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: sulfation; MF: aryl sulfotransferase activity, cholesterol sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, lysosome, mitochondrion
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Metabolism, Phase II - Conjugation of compounds
UniProt: Q9D939
Entrez ID: 69083
|
Does Knockout of Atg5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,276
|
Knockout
|
Atg5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Atg5 (autophagy related 5)
Type: protein-coding
Summary: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: aggrephagy, antigen processing and presentation of endogenous antigen, apoptotic process, autophagosome assembly, autophagy, axonal transport, blood vessel remodeling, cellular response to nitrogen starvation, cellular response to nitrosative stress, cellular response to starvation, chaperone-mediated autophagy, chromatin organization, defense response to virus, establishment of localization in cell, heart contraction, immune system process, innate immune response, macroautophagy, mitophagy, negative regulation of apoptotic process, negative regulation of autophagic cell death, negative regulation of cardiac muscle cell apoptotic process, negative regulation of defense response to virus, negative regulation of innate immune response, negative regulation of phagocytosis, negative regulation of protein ubiquitination, negative regulation of type I interferon production, negative stranded viral RNA replication, negative thymic T cell selection, otolith development, piecemeal microautophagy of the nucleus, positive regulation of autophagy, positive regulation of mucus secretion, positive regulation of stress granule assembly, positive regulation of viral translation, post-translational protein modification, postsynaptic modulation of chemical synaptic transmission, regulation of autophagosome maturation, regulation of cilium assembly, regulation of cytokine production involved in immune response, regulation of organelle assembly, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of reactive oxygen species metabolic process, regulation of release of sequestered calcium ion into cytosol, response to fluoride, response to fungus, response to iron(II) ion, response to xenobiotic stimulus, vasodilation, ventricular cardiac muscle cell development; MF: Atg8-family ligase activity, protein binding; CC: Atg12-Atg5-Atg16 complex, Schaffer collateral - CA1 synapse, autophagosome, axon, axoneme, cytoplasm, cytosol, glutamatergic synapse, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, phagophore, phagophore assembly site membrane, postsynapse, protein-containing complex, synapse, transferase complex
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q99J83
Entrez ID: 11793
|
Does Knockout of Hps4 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Hps4
|
cell proliferation
|
Regulatory T cell
|
Gene: Hps4 (HPS4, biogenesis of lysosomal organelles complex 3 subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, lysosome organization, melanocyte differentiation, melanosome assembly, platelet dense granule organization, protein stabilization, protein targeting, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, protein dimerization activity, protein homodimerization activity, small GTPase binding; CC: BLOC-3 complex, cytoplasm, cytoplasmic vesicle, lysosomal membrane, lysosome, melanosome, membrane, platelet dense granule
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q99KG7
Entrez ID: 192232
|
Does Knockout of Pcdhb11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pcdhb11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcdhb11 (protocadherin beta 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8C5K2, Q91UZ8
Entrez ID: 93882
|
Does Knockout of Dnd1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Dnd1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dnd1 (DND microRNA-mediated repression inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, germ cell development, mRNA stabilization, negative regulation of miRNA-mediated gene silencing, spermatogenesis; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, miRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytosol, focal adhesion, nucleoplasm, nucleus
Pathways:
UniProt: Q6VY05
Entrez ID: 213236
|
Does Knockout of Gga1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Gga1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Gga1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein localization, intracellular protein transport, positive regulation of protein catabolic process, protein localization to cell periphery, protein localization to cell surface, protein localization to ciliary membrane, protein localization to membrane, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding, small GTPase binding, ubiquitin binding; CC: Golgi apparatus, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, membrane, nucleoplasm, protein-containing complex, trans-Golgi network
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q8R0H9
Entrez ID: 106039
|
Does Knockout of Cfl1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Cfl1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Cfl1 (cofilin 1, non-muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament depolymerization, actin filament fragmentation, actin filament organization, actin filament severing, cell motility, cell projection organization, cellular response to epidermal growth factor stimulus, cellular response to ether, cellular response to hydrogen peroxide, cellular response to insulin-like growth factor stimulus, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to tumor necrosis factor, cytoskeleton organization, establishment of cell polarity, establishment of spindle localization, hippocampus development, host-mediated activation of viral process, mitotic cytokinesis, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulation of actin filament depolymerization, negative regulation of cell adhesion, negative regulation of cell motility, negative regulation of cell size, negative regulation of dendritic spine maintenance, negative regulation of lamellipodium assembly, negative regulation of postsynaptic density organization, negative regulation of unidimensional cell growth, neural crest cell migration, neural fold formation, positive regulation of actin filament depolymerization, positive regulation of barbed-end actin filament capping, positive regulation of cell growth, positive regulation of cell motility, positive regulation of dendritic spine development, positive regulation of embryonic development, positive regulation of establishment of cell polarity regulating cell shape, positive regulation of focal adhesion assembly, positive regulation of lamellipodium assembly, positive regulation of protein localization to cell leading edge, positive regulation of proteolysis, positive regulation of synaptic plasticity, protein import into nucleus, regulation of cell morphogenesis, regulation of dendritic spine morphogenesis, response to activity, response to amino acid, response to virus; MF: actin binding, actin filament binding, phosphatidylinositol bisphosphate binding, protein binding, protein phosphatase binding, signaling receptor binding; CC: actin cytoskeleton, axon, cell leading edge, cell projection, cell-cell junction, cofilin-actin rod, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, dendritic spine, extracellular region, filopodium, focal adhesion, glutamatergic synapse, growth cone, lamellipodium, lamellipodium membrane, membrane, mitochondrial membrane, neuronal cell body, nuclear matrix, nucleus, plasma membrane, postsynaptic density, intracellular component, ruffle membrane, synaptic membrane
Pathways: Axon guidance - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: P18760
Entrez ID: 12631
|
Does Knockout of Pagr1a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Pagr1a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pagr1a (PAXIP1 associated glutamate rich protein 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chorion development, positive regulation of cell cycle G1/S phase transition, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of isotype switching to IgG isotypes, positive regulation of transcription by RNA polymerase II, regulation of cell cycle G2/M phase transition; MF: nuclear estrogen receptor binding, protein binding; CC: MLL3/4 complex, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q99L02
Entrez ID: 67278
|
Does Knockout of Niban1 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Niban1
|
response to bacteria
|
macrophage
|
Gene: Niban1 (niban apoptosis regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of translation, regulation of translation, response to endoplasmic reticulum stress; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q3UW53
Entrez ID: 63913
|
Does Knockout of Ttyh2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ttyh2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ttyh2 (tweety family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium ion binding, chloride channel activity, intracellularly calcium-gated chloride channel activity, volume-sensitive anion channel activity, volume-sensitive chloride channel activity; CC: chloride channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q3TH73
Entrez ID: 117160
|
Does Knockout of Lipn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Lipn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lipn (lipase, family member N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, lipase activity, sterol ester esterase activity, triacylglycerol lipase activity; CC: extracellular region, intracellular membrane-bounded organelle
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q3U4B4
Entrez ID: 70166
|
Does Knockout of Rab7b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Rab7b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rab7b (RAB7B, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, endosome to lysosome transport, late endosome to Golgi transport, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of toll-like receptor 9 signaling pathway, phagosome-lysosome fusion, positive regulation of NF-kappaB transcription factor activity, positive regulation of interleukin-6 production, positive regulation of megakaryocyte differentiation, protein transport, regulation of immune system process; MF: G protein activity, GTP binding, GTPase activity, nucleotide binding; CC: Golgi apparatus, cytoplasmic vesicle, endosome, late endosome, lysosome, membrane, phagocytic vesicle, phagocytic vesicle membrane, trans-Golgi network
Pathways: Amoebiasis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Mitophagy - animal - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Salmonella infection - Mus musculus (mouse), TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q8VEA8
Entrez ID: 226421
|
Does Knockout of Ap1m1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Ap1m1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ap1m1 (adaptor-related protein complex AP-1, mu subunit 1)
Type: protein-coding
Summary: This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: endosome to melanosome transport, intracellular protein transport, melanosome assembly, melanosome organization, platelet dense granule organization, protein transport, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-1 adaptor complex, Golgi apparatus, clathrin adaptor complex, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytosol, early endosome, lysosomal membrane, membrane, synapse, trans-Golgi network, trans-Golgi network membrane
Pathways: Adaptive Immune System, Golgi Associated Vesicle Biogenesis, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Neutrophil degranulation, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P35585
Entrez ID: 11767
|
Does Knockout of Zfp568 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Zfp568
|
cell cycle progression
|
breast epithelium
|
Gene: Zfp568 (zinc finger protein 568)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: convergent extension involved in axis elongation, convergent extension involved in neural plate elongation, embryonic placenta morphogenesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell communication, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription corepressor binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: E9PYI1
Entrez ID: 243905
|
Does Knockout of Rhd in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Rhd
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rhd (Rh blood group, D antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ammonium homeostasis, ammonium transmembrane transport, erythrocyte development, multicellular organismal-level iron ion homeostasis; MF: ammonium channel activity; CC: ankyrin-1 complex, membrane, plasma membrane
Pathways:
UniProt: Q8CF94
Entrez ID: 19746
|
Does Knockout of Pstk in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Pstk
|
phagocytosis
|
macrophage
|
Gene: Pstk (phosphoseryl-tRNA kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: selenocysteine incorporation, translation; MF: ATP binding, L-seryl-tRNA(Sec) kinase activity, kinase activity, nucleotide binding, tRNA binding, transferase activity; CC: cytosol, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse)
UniProt: Q8BP74
Entrez ID: 214580
|
Does Knockout of Tal2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Tal2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Tal2 (T cell acute lymphocytic leukemia 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: midbrain development, multicellular organism growth, post-embryonic development, regulation of transcription by RNA polymerase II, thalamus development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity
Pathways:
UniProt: Q62282
Entrez ID: 21350
|
Does Knockout of Sgca in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Sgca
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sgca (sarcoglycan, alpha (dystrophin-associated glycoprotein))
Type: protein-coding
Summary: This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012].
Gene Ontology: CC: cell-cell junction, cytoplasm, cytoskeleton, dystroglycan complex, dystrophin-associated glycoprotein complex, membrane, membrane raft, plasma membrane, sarcoglycan complex, sarcolemma
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Non-integrin membrane-ECM interactions, Viral myocarditis - Mus musculus (mouse)
UniProt: P82350
Entrez ID: 20391
|
Does Knockout of Mal2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Mal2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mal2 (mal, T cell differentiation protein 2)
Type: protein-coding
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in membrane raft. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Is expressed in gut; olfactory epithelium; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human MAL2 (mal, T cell differentiation protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: apical plasma membrane, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, membrane raft, plasma membrane, synaptic vesicle membrane
Pathways:
UniProt: Q8BI08
Entrez ID: 105853
|
Does Knockout of Sco1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Sco1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sco1 (SCO1 cytochrome c oxidase assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: copper ion homeostasis, cyclooxygenase pathway, gene expression, homeostasis of number of cells, immune response, intracellular copper ion homeostasis, intracellular iron ion homeostasis, intracellular zinc ion homeostasis, leukocyte differentiation, lipid catabolic process, liver development, mitochondrial cytochrome c oxidase assembly, mitochondrion organization, multicellular organism growth, negative regulation of cellular response to insulin stimulus, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal protein catabolic process, positive regulation of CAMKK-AMPK signaling cascade, post-transcriptional regulation of gene expression, protein localization to plasma membrane, protein secretion, respiratory chain complex IV assembly, spleen development, thymus development; MF: metal ion binding, molecular_function, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, myofibril
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport
UniProt: Q5SUC9
Entrez ID: 52892
|
Does Knockout of Hgf in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Hgf
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Hgf (hepatocyte growth factor)
Type: protein-coding
Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: animal organ development, cell chemotaxis, cell morphogenesis, cellular response to hepatocyte growth factor stimulus, epithelial cell proliferation, hepatocyte growth factor receptor signaling pathway, liver development, myoblast proliferation, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of hydrogen peroxide-mediated programmed cell death, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of release of cytochrome c from mitochondria, positive chemotaxis, positive regulation of DNA biosynthetic process, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of interleukin-10 production, positive regulation of myelination, positive regulation of neuron projection regeneration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, proteolysis, regulation of anatomical structure morphogenesis, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, regulation of multicellular organismal process, regulation of p38MAPK cascade, signal transduction, skeletal muscle cell proliferation; MF: chemoattractant activity, endopeptidase activity, growth factor activity, identical protein binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Drug-mediated inhibition of MET activation, Focal adhesion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hemostasis, Hepatocellular carcinoma - Mus musculus (mouse), Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, MET Receptor Activation, MET activates PI3K/AKT signaling, MET activates PTK2 signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET activates RAS signaling, MET activates STAT3, MET interacts with TNS proteins, MET promotes cell motility, MET receptor recycling, Malaria - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Negative regulation of MET activity, Negative regulation of the PI3K/AKT network, Non-small cell lung cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q08048
Entrez ID: 15234
|
Does Knockout of Lrrc28 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Lrrc28
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lrrc28 (leucine rich repeat containing 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: PML body, cellular_component
Pathways:
UniProt: Q3TX51
Entrez ID: 67867
|
Does Knockout of Foxc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Foxc1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Foxc1 (forkhead box C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, anatomical structure morphogenesis, angiogenesis, artery morphogenesis, blood vessel development, blood vessel diameter maintenance, blood vessel remodeling, brain development, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell migration, cell population proliferation, cellular response to chemokine, cellular response to epidermal growth factor stimulus, cerebellum development, chemokine-mediated signaling pathway, collagen fibril organization, embryonic heart tube development, endochondral ossification, eye development, germ cell migration, glomerular epithelium development, glycosaminoglycan metabolic process, heart development, heart morphogenesis, in utero embryonic development, kidney development, lacrimal gland development, lymph vessel development, maintenance of lens transparency, mesenchymal cell development, mesenchymal cell differentiation, negative regulation of angiogenesis, negative regulation of apoptotic process involved in outflow tract morphogenesis, negative regulation of lymphangiogenesis, negative regulation of mitotic cell cycle, negative regulation of transcription by RNA polymerase II, neural crest cell development, odontogenesis of dentin-containing tooth, ossification, ovarian follicle development, paraxial mesoderm formation, positive regulation of DNA binding, positive regulation of DNA-templated transcription, positive regulation of core promoter binding, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of hematopoietic stem cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of organ growth, regulation of transcription by RNA polymerase II, skeletal system development, somitogenesis, ureteric bud development, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway, ventricular cardiac muscle tissue morphogenesis; MF: DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: cytosol, heterochromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q61572
Entrez ID: 17300
|
Does Knockout of Pex19 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pex19
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pex19 (peroxisomal biogenesis factor 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of protein localization to peroxisome, peroxisome fission, peroxisome membrane biogenesis, peroxisome organization, protein folding, protein import into peroxisome membrane, protein stabilization, protein targeting to peroxisome; MF: ATPase binding, peroxisome membrane class-1 targeting sequence binding, peroxisome membrane targeting sequence binding, protein binding, protein carrier chaperone; CC: brush border membrane, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, peroxisomal membrane, peroxisome, protein-containing complex
Pathways: ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Class I peroxisomal membrane protein import, Peroxisome - Mus musculus (mouse), Protein localization, Transport of small molecules
UniProt: Q8VCI5
Entrez ID: 19298
|
Does Knockout of Rxfp2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Rxfp2
|
phagocytosis
|
macrophage
|
Gene: Rxfp2 (relaxin/insulin-like family peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, hormone-mediated signaling pathway, male gonad development, negative regulation of apoptotic process, negative regulation of cell population proliferation, oocyte maturation, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, peptide hormone binding, protein-hormone receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Relaxin receptors, Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q91ZZ5
Entrez ID: 140498
|
Does Knockout of Tuft1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tuft1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tuft1 (tuftelin 1)
Type: protein-coding
Summary: Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014].
Gene Ontology: MF: protein binding, structural constituent of skin epidermis; CC: I band, RNA polymerase II, core complex, cytoplasm, extracellular region
Pathways:
UniProt: O08970
Entrez ID: 22156
|
Does Knockout of Mir6976 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Mir6976
|
cell cycle progression
|
breast epithelium
|
Gene: Mir6976 (microRNA 6976)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466778
|
Does Knockout of Gabrb3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Gabrb3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gabrb3 (GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to histamine, cellular response to zinc ion, cerebellum development, chemical synaptic transmission, chloride transmembrane transport, chloride transport, circadian sleep/wake cycle, REM sleep, cochlea development, exploration behavior, gamma-aminobutyric acid signaling pathway, hard palate development, inhibitory postsynaptic potential, inhibitory synapse assembly, inner ear receptor cell development, innervation, learning, memory, monoatomic ion transmembrane transport, monoatomic ion transport, motor behavior, nervous system development, neuron development, reproductive behavior, response to anesthetic, response to xenobiotic stimulus, roof of mouth development, social behavior, synaptic transmission, GABAergic; MF: AP-2 adaptor complex binding, GABA-A receptor activity, GABA-gated chloride ion channel activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, identical protein binding, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA-A receptor complex, GABA-ergic synapse, cell surface, chloride channel complex, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendritic spine, inhibitory synapse, membrane, plasma membrane, postsynaptic membrane, postsynaptic specialization membrane, sperm head, synapse, terminal bouton
Pathways: GABA receptor activation, GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: P63080
Entrez ID: 14402
|
Does Knockout of Gm15114 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Gm15114
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Gm15114 (predicted gene 15114)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1B0X6
Entrez ID: 100034729
|
Does Knockout of Tcerg1l in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Tcerg1l
|
phagocytosis
|
macrophage
|
Gene: Tcerg1l (transcription elongation regulator 1-like)
Type: protein-coding
Summary: Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TCERG1L (transcription elongation regulator 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA polymerase binding, transcription coregulator activity
Pathways:
UniProt: Q3B807
Entrez ID: 70571
|
Does Knockout of Tmprss2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tmprss2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tmprss2 (transmembrane protease, serine 2)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: entry receptor-mediated virion attachment to host cell, positive regulation of viral entry into host cell, protein autoprocessing, proteolysis; MF: hydrolase activity, metal ion binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, membrane, nucleoplasm, plasma membrane
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9JIQ8
Entrez ID: 50528
|
Does Knockout of Tmc7 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tmc7
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tmc7 (transmembrane channel-like gene family 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, sensory perception of mechanical stimulus; MF: ion channel inhibitor activity, mechanosensitive monoatomic ion channel activity, protein binding; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8C428
Entrez ID: 209760
|
Does Knockout of Adgra1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Adgra1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Adgra1 (adhesion G protein-coupled receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway; MF: G protein-coupled receptor activity, molecular_function, transmembrane signaling receptor activity; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density
Pathways:
UniProt: Q8C4G9
Entrez ID: 52389
|
Does Knockout of Spice1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Spice1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Spice1 (spindle and centriole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, metaphase chromosome alignment, mitotic spindle assembly, regulation of centriole replication; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, plasma membrane, spindle
Pathways:
UniProt: Q8C804
Entrez ID: 212514
|
Does Knockout of Slc45a1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Slc45a1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Slc45a1 (solute carrier family 45, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose transmembrane transport, galactose transmembrane transport, sucrose transport, transmembrane transport; MF: D-glucose:proton symporter activity, galactose:proton symporter activity, sucrose:proton symporter activity, symporter activity, transmembrane transporter activity; CC: membrane
Pathways:
UniProt: Q8BIV7
Entrez ID: 242773
|
Does Knockout of Mybl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mybl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mybl1 (myeloblastosis oncogene-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, mitotic cell cycle, positive regulation of piRNA transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, promoter-specific chromatin binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P51960
Entrez ID: 17864
|
Does Knockout of Mecom in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mecom
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mecom (MDS1 and EVI1 complex locus)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell differentiation, chromatin remodeling, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, forebrain development, hematopoietic stem cell proliferation, heterochromatin organization, in utero embryonic development, inflammatory response, maintenance of cell number, methylation, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of programmed cell death, neutrophil homeostasis, pericardium development, positive regulation of DNA-templated transcription, positive regulation of brown fat cell differentiation, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of cell cycle, regulation of hematopoietic stem cell proliferation, regulation of transcription by RNA polymerase II, response to bacterium, ureter morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, histone H3K9 methyltransferase activity, histone H3K9 monomethyltransferase activity, histone H3K9me2 methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, protein homodimerization activity, transferase activity, zinc ion binding; CC: cytoplasm, histone deacetylase complex, nuclear speck, nucleoplasm, nucleus
Pathways: Chronic myeloid leukemia - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P14404
Entrez ID: 14013
|
Does Knockout of Usp45 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,523
|
Knockout
|
Usp45
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Usp45 (ubiquitin specific petidase 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, cell migration, neural retina development, photoreceptor cell maintenance, protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, photoreceptor inner segment
Pathways: DNA Repair, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Nucleotide Excision Repair
UniProt: Q8K387
Entrez ID: 77593
|
Does Knockout of Gria2 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Gria2
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, cellular response to glycine, chemical synaptic transmission, conditioned place preference, establishment of protein localization, excitatory postsynaptic potential, ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of synaptic transmission, protein tetramerization, receptor internalization, regulation of long-term synaptic depression, regulation of postsynaptic membrane potential, regulation of receptor recycling, regulation of synaptic transmission, glutamatergic, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, PDZ domain binding, SNARE binding, amyloid-beta binding, cytoskeletal protein binding, extracellular ligand-gated monoatomic ion channel activity, extracellularly glutamate-gated ion channel activity, glutamate receptor binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, identical protein binding, immunoglobulin binding, ionotropic glutamate receptor binding, kainate selective glutamate receptor activity, ligand-gated monoatomic cation channel activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, protein kinase binding, protein-containing complex binding, scaffold protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, Schaffer collateral - CA1 synapse, asymmetric synapse, axon, cell surface, dendrite, dendrite cytoplasm, dendrite membrane, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endoplasmic reticulum, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, neuron projection, neuronal cell body, perikaryon, perisynaptic space, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynapse, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, somatodendritic compartment, spine synapse, synapse, synaptic membrane, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways: Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q4LG64, E9QKC0, G5E8H1, A0A0A6YW90
Entrez ID: 14800
|
Does Knockout of Rbm34 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rbm34
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rbm34 (RNA binding motif protein 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, molecular_function, nucleic acid binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8C5L7
Entrez ID: 52202
|
Does Knockout of Il17a in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Il17a
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Il17a (interleukin 17A)
Type: protein-coding
Summary: This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Notch signaling pathway, adaptive immune response, cellular response to glucocorticoid stimulus, cellular response to interleukin-1, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to fungus, fibroblast activation, gene expression, granulocyte migration, immune system process, inflammatory response, innate immune response, interleukin-17-mediated signaling pathway, interleukin-17A-mediated signaling pathway, intestinal epithelial structure maintenance, keratinocyte differentiation, keratinocyte proliferation, mRNA stabilization, negative regulation of inflammatory response to wounding, negative regulation of interleukin-17-mediated signaling pathway, positive regulation of antimicrobial peptide production, positive regulation of bicellular tight junction assembly, positive regulation of chemokine (C-X-C motif) ligand 1 production, positive regulation of cytokine production involved in inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-16 production, positive regulation of interleukin-23 production, positive regulation of interleukin-6 production, positive regulation of keratinocyte proliferation, positive regulation of osteoclast differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, regulation of primary metabolic process, response to wounding; MF: cytokine activity, protein binding, protein heterodimerization activity, protein homodimerization activity, signaling receptor binding; CC: external side of plasma membrane, extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q62386
Entrez ID: 16171
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Does Knockout of Mex3d in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Mex3d
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Mex3d (mex3 RNA binding family member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA destabilization, mRNA catabolic process, mRNA destabilization; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q3UE17
Entrez ID: 237400
|
Does Knockout of Btbd35f14 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Btbd35f14
|
cell cycle progression
|
breast epithelium
|
Gene: Btbd35f14 (BTB domain containing 35, family member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: Q1LZI5
Entrez ID: 100040732
|
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