prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Rimklb in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Rimklb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rimklb (ribosomal modification protein rimK-like family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, N-acetyl-L-aspartate-L-glutamate ligase activity, citrate-L-glutamate ligase activity, ligase activity, metal ion binding, nucleotide binding; CC: cytoplasm
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Glutamate and glutamine metabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q80WS1
Entrez ID: 108653
|
Does Knockout of Mpv17l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Mpv17l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mpv17l (Mpv17 transgene, kidney disease mutant-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of hydrogen peroxide biosynthetic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, reactive oxygen species metabolic process; CC: cytoplasm, membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Peroxisome - Mus musculus (mouse)
UniProt: Q99MS3
Entrez ID: 93734
|
Does Knockout of Mrpl12 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mrpl12
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mrpl12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial transcription, mitochondrial translation, positive regulation of DNA-templated transcription, translation; MF: mRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DB15
Entrez ID: 56282
|
Does Knockout of Dsc3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Dsc3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dsc3 (desmocollin 3)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, in utero embryonic development, protein stabilization; MF: calcium ion binding, gamma-catenin binding, metal ion binding; CC: anchoring junction, cell junction, cytoplasm, desmosome, extracellular region, membrane, plasma membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P55850
Entrez ID: 13507
|
Does Knockout of Nucb2 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Nucb2
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Nucb2 (nucleobindin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin metabolic process, intracellular calcium ion homeostasis, negative regulation of appetite, negative regulation of cAMP/PKA signal transduction, negative regulation of fat cell differentiation, negative regulation of glucagon secretion, negative regulation of insulin receptor signaling pathway, positive regulation of fatty acid oxidation, positive regulation of testosterone secretion, small GTPase-mediated signal transduction; MF: DNA binding, G-protein alpha-subunit binding, calcium ion binding, guanyl-nucleotide exchange factor activity, metal ion binding, tumor necrosis factor receptor binding; CC: Golgi apparatus, Golgi medial cisterna, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, extracellular space, membrane, nuclear envelope, nuclear outer membrane, nucleus, perikaryon
Pathways:
UniProt: P81117
Entrez ID: 53322
|
Does Knockout of Stap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Stap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Stap1 (signal transducing adaptor family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, cellular response to lipopolysaccharide, myeloid cell differentiation, negative regulation of macrophage chemotaxis, negative regulation of macrophage colony-stimulating factor signaling pathway, negative regulation of microglial cell migration, negative regulation of ruffle assembly, positive regulation of B cell receptor signaling pathway, positive regulation of gene expression, positive regulation of microglial cell activation, positive regulation of microglial cell mediated cytotoxicity, positive regulation of phagocytosis, engulfment, response to bacterium; MF: macrophage colony-stimulating factor receptor binding, phosphotyrosine residue binding, protein binding, protein kinase binding, protein tyrosine kinase activator activity, protein-macromolecule adaptor activity, receptor tyrosine kinase binding, signaling adaptor activity, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytoplasm, cytosol, mitochondrion, nuclear body, nucleus, protein-containing complex
Pathways:
UniProt: Q9JM90
Entrez ID: 56792
|
Does Knockout of Gdf10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Gdf10
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gdf10 (growth differentiation factor 10)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell surface receptor protein serine/threonine kinase signaling pathway, cerebellum development, fat cell differentiation, negative regulation of ossification, ossification, osteoblast differentiation, ovulation cycle, positive regulation of osteoblast differentiation, regulation of ossification, response to kainic acid, response to transforming growth factor beta; MF: cytokine activity, growth factor activity; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse)
UniProt: P97737
Entrez ID: 14560
|
Does Knockout of Il34 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Il34
|
phagocytosis
|
macrophage
|
Gene: Il34 (interleukin 34)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and macrophage colony-stimulating factor receptor binding activity. Involved in microglial cell proliferation; positive regulation of gene expression; and positive regulation of oligodendrocyte differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and mammary gland. Orthologous to human IL34 (interleukin 34). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, interleukin-34-mediated signaling pathway, microglial cell proliferation, positive regulation of MAPK cascade, positive regulation of cell development, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of macromolecule metabolic process, positive regulation of macrophage chemotaxis, positive regulation of macrophage differentiation, positive regulation of macrophage proliferation, positive regulation of monocyte differentiation, positive regulation of multicellular organismal process, positive regulation of oligodendrocyte differentiation, positive regulation of protein phosphorylation, regulation of multicellular organismal development; MF: cytokine activity, growth factor activity, identical protein binding, macrophage colony-stimulating factor receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Other interleukin signaling, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q8R1R4
Entrez ID: 76527
|
Does Knockout of Tbc1d23 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Tbc1d23
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tbc1d23 (TBC1 domain family, member 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, brain development, embryonic brain development, nervous system development, neuron projection development, positive regulation of interleukin-6 production, regulation of inflammatory response, regulation of tumor necrosis factor production, retrograde transport, endosome to Golgi, vesicle tethering to Golgi, vesicle-mediated transport; CC: Golgi apparatus, WASH complex, cytoplasmic vesicle, cytosol, trans-Golgi network
Pathways:
UniProt: Q8K0F1
Entrez ID: 67581
|
Does Knockout of Gm10419 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gm10419
|
phagocytosis
|
macrophage
|
Gene: Gm10419 (predicted gene 10419)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Uqcc1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Uqcc1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Uqcc1 (ubiquinol-cytochrome c reductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly; CC: cytoplasmic vesicle, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CWU6
Entrez ID: 56046
|
Does Knockout of Sulf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Sulf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sulf1 (sulfatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bone development, cartilage condensation, cartilage development, cell adhesion, chondrocyte development, embryonic skeletal system development, esophagus smooth muscle contraction, glial cell-derived neurotrophic factor receptor signaling pathway, glomerular basement membrane development, glomerular filtration, heparan sulfate proteoglycan metabolic process, innervation, kidney development, limb joint morphogenesis, negative regulation of angiogenesis, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of prostatic bud formation, positive regulation of BMP signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of vascular endothelial growth factor production, regulation of fibroblast growth factor receptor signaling pathway, sulfur compound metabolic process, vascular endothelial growth factor receptor signaling pathway; MF: N-acetylglucosamine-6-sulfatase activity, arylsulfatase activity, calcium ion binding, glycosaminoglycan binding, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: Golgi apparatus, Golgi stack, cell surface, endoplasmic reticulum, extracellular region, extracellular space, membrane raft, plasma membrane
Pathways:
UniProt: Q8K007
Entrez ID: 240725
|
Does Knockout of Cga in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Cga
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cga (glycoprotein hormones, alpha subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to hormone stimulus, developmental growth, follicle-stimulating hormone secretion, gonad development, luteinizing hormone secretion, negative regulation of organ growth, positive regulation of steroid biosynthetic process, regulation of signaling receptor activity, thyroid gland development, thyroid hormone generation; MF: follicle-stimulating hormone activity, hormone activity; CC: extracellular region, extracellular space, follicle-stimulating hormone complex, pituitary gonadotropin complex
Pathways: Androgen biosynthesis, Asparagine N-linked glycosylation, Autoimmune thyroid disease - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Gene expression (Transcription), Generic Transcription Pathway, Glycoprotein hormones, GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hormone ligand-binding receptors, Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, Mineralocorticoid biosynthesis, N-glycan antennae elongation in the medial/trans-Golgi, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Peptide hormone biosynthesis, Peptide hormone metabolism, Post-translational protein modification, Prolactin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Reactions specific to the complex N-glycan synthesis pathway, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Thyroid hormone synthesis - Mus musculus (mouse), Thyroxine biosynthesis, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transport to the Golgi and subsequent modification, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P01216
Entrez ID: 12640
|
Does Knockout of Nbr1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Nbr1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nbr1 (NBR1, autophagy cargo receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macroautophagy, negative regulation of osteoblast differentiation, regulation of bone mineralization, regulation of stress-activated MAPK cascade; MF: metal ion binding, mitogen-activated protein kinase binding, protein binding, ubiquitin binding, zinc ion binding; CC: M band, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, intracellular organelle lumen, late endosome, lysosome, mitochondrial intermembrane space, mitochondrion, nuclear body, nucleoplasm, peroxisomal membrane, phagophore assembly site, receptor complex
Pathways: Autophagy, Macroautophagy, Mitophagy - animal - Mus musculus (mouse), Pexophagy, Selective autophagy
UniProt: P97432
Entrez ID: 17966
|
Does Knockout of Rhobtb3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Rhobtb3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rhobtb3 (Rho-related BTB domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: male gonad development, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of proteolysis, retrograde transport, endosome to Golgi; MF: ATP binding, ATP hydrolysis activity, GTPase activity, hydrolase activity, nucleotide binding, protein binding, small GTPase binding, ubiquitin protein ligase binding; CC: Golgi apparatus, cytoplasm, cytosol
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, RHOBTB3 ATPase cycle, Retrograde transport at the Trans-Golgi-Network, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9CTN4
Entrez ID: 73296
|
Does Knockout of 1700001O22Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
1700001O22Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: 1700001O22Rik (RIKEN cDNA 1700001O22 gene)
Type: protein-coding
Summary: Orthologous to human C9orf50 (chromosome 9 open reading frame 50). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: A2APZ1
Entrez ID: 73598
|
Does Knockout of Cyp2b9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cyp2b9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cyp2b9 (cytochrome P450, family 2, subfamily b, polypeptide 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, ketone metabolic process, response to stilbenoid, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, arachidonate epoxygenase activity, estrogen 2-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, testosterone 16-alpha-hydroxylase activity, testosterone 16-beta-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P12790
Entrez ID: 13094
|
Does Knockout of Gm3558 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Gm3558
|
response to bacteria
|
renal medulla cell line
|
Gene: Gm3558 (predicted gene 3558)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5FWC9
Entrez ID: 100041874
|
Does Knockout of Gkn1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gkn1
|
response to virus
|
Microglial Cell Line
|
Gene: Gkn1 (gastrokine 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell division, positive regulation of cell population proliferation, regulation of cell population proliferation, signal transduction; CC: Golgi apparatus, cytoplasm, endomembrane system, extracellular region, extracellular space, secretory granule
Pathways:
UniProt: Q9CR36
Entrez ID: 66283
|
Does Knockout of Ruvbl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ruvbl1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ruvbl1 (RuvB-like AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomere maintenance; MF: 3'-5' DNA helicase activity, ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, TBP-class protein binding, TFIID-class transcription factor complex binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, transcription coactivator activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dynein axonemal particle, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Chromosome Maintenance, DNA Damage Recognition in GG-NER, DNA Repair, Deposition of new CENPA-containing nucleosomes at the centromere, Deubiquitination, Formation of the beta-catenin:TCF transactivating complex, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleosome assembly, Nucleotide Excision Repair, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, UCH proteinases, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P60122
Entrez ID: 56505
|
Does Knockout of Ces2d-ps in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ces2d-ps
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ces2d-ps (carboxylesterase 2D, pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 667754
|
Does Knockout of Acot13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Acot13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acot13 (acyl-CoA thioesterase 13)
Type: protein-coding
Summary: Enables fatty acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrial matrix. Is expressed in chondrocranium; hindgut; and midgut. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, negative regulation of cold-induced thermogenesis, protein homotetramerization; MF: fatty acyl-CoA hydrolase activity, hydrolase activity; CC: cytoplasm, cytoskeleton, cytosol, mitochondrial matrix, mitochondrion, nucleus, spindle
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q9CQR4
Entrez ID: 66834
|
Does Knockout of Irak3 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Irak3
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Irak3 (interleukin-1 receptor-associated kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Toll signaling pathway, apoptotic process, cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, intracellular signal transduction, lipopolysaccharide-mediated signaling pathway, negative regulation of MAPK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine-mediated signaling pathway, negative regulation of innate immune response, negative regulation of interleukin-12 production, negative regulation of interleukin-6 production, negative regulation of macrophage cytokine production, negative regulation of protein catabolic process, negative regulation of protein-containing complex disassembly, negative regulation of toll-like receptor signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of immune system process, positive regulation of macrophage tolerance induction, protein phosphorylation, regulation of apoptotic process, regulation of innate immune response, regulation of protein-containing complex disassembly, response to exogenous dsRNA, response to interleukin-1, response to lipopolysaccharide, response to peptidoglycan, response to virus, signal transduction; MF: ATP binding, magnesium ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity; CC: cytoplasm, nucleus, plasma membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Neurotrophin signaling pathway - Mus musculus (mouse), Signaling by Interleukins
UniProt: Q8K4B2
Entrez ID: 73914
|
Does Knockout of Adtrp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Adtrp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adtrp (androgen dependent TFPI regulating protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration involved in sprouting angiogenesis, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to steroid hormone stimulus, lipid metabolic process, long-chain fatty acid catabolic process, negative regulation of blood coagulation, negative regulation of extracellular matrix constituent secretion, negative regulation of leukocyte cell-cell adhesion, negative regulation of leukocyte migration, negative regulation of lymphocyte migration, negative regulation of protein secretion, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: hydrolase activity; CC: caveola, cell surface, endomembrane system, membrane, plasma membrane
Pathways:
UniProt: Q8C138
Entrez ID: 109254
|
Does Knockout of Dpf3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Dpf3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Dpf3 (double PHD fingers 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, muscle cell differentiation, muscle organ development, nervous system development, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, zinc ion binding; CC: SWI/SNF complex, brahma complex, chromatin, nBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of the canonical BAF (cBAF) complex, Hepatocellular carcinoma - Mus musculus (mouse), SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse)
UniProt: P58269
Entrez ID: 70127
|
Does Knockout of Mrpl55 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Mrpl55
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mrpl55 (mitochondrial ribosomal protein L55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CZ83
Entrez ID: 67212
|
Does Knockout of Etv6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Etv6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Etv6 (ets variant 6)
Type: protein-coding
Summary: This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: cell differentiation, hematopoietic stem cell proliferation, mesenchymal cell apoptotic process, negative regulation of transcription by RNA polymerase II, neurogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, vitellogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein domain specific binding, sequence-specific DNA binding; CC: cytosol, nucleolus, nucleus
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P97360
Entrez ID: 14011
|
Does Knockout of Prg2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Prg2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Prg2 (proteoglycan 2, bone marrow)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to bacterium, defense response to nematode, immune response, immune system process, negative regulation of interleukin-10 production, negative regulation of macrophage cytokine production, positive regulation of interleukin-4 production; MF: carbohydrate binding, extracellular matrix structural constituent conferring compression resistance; CC: extracellular matrix, extracellular region
Pathways: Asthma - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q61878
Entrez ID: 19074
|
Does Knockout of Copz1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Copz1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Copz1 (coatomer protein complex, subunit zeta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane, membrane coat
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61924
Entrez ID: 56447
|
Does Knockout of Slc41a1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Slc41a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc41a1 (solute carrier family 41, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to magnesium ion, intracellular magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, metal ion transport, monoatomic cation transport, monoatomic ion transport, sodium ion transmembrane transport; MF: inorganic cation transmembrane transporter activity, magnesium ion transmembrane transporter activity, magnesium:sodium antiporter activity, monoatomic cation transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q8BJA2
Entrez ID: 98396
|
Does Knockout of Dlg3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Dlg3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dlg3 (discs large MAGUK scaffold protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell adhesion, chemical synaptic transmission, establishment of planar polarity, establishment or maintenance of epithelial cell apical/basal polarity, nervous system development, protein localization to synapse, receptor clustering, receptor localization to synapse, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: PDZ domain binding, ionotropic glutamate receptor binding, kinase binding, phosphatase binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, structural constituent of postsynaptic density, ubiquitin protein ligase binding; CC: AMPA glutamate receptor complex, basolateral plasma membrane, bicellular tight junction, cell-cell junction, cytoplasm, dendritic shaft, glutamatergic synapse, growth cone, neuromuscular junction, neuron projection, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic density, intracellular component, synapse
Pathways: Activation of Ca-permeable Kainate Receptor, Activation of NMDA receptors and postsynaptic events, Activation of kainate receptors upon glutamate binding, Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Ionotropic activity of kainate receptors, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Neurexins and neuroligins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Protein-protein interactions at synapses, RAF/MAP kinase cascade, Signal Transduction, Synaptic adhesion-like molecules, Tight junction - Mus musculus (mouse), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation
UniProt: P70175
Entrez ID: 53310
|
Does Knockout of A3galt2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
A3galt2
|
response to virus
|
Microglial Cell Line
|
Gene: A3galt2 (alpha 1,3-galactosyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cellular response to manganese ion, glycosphingolipid biosynthetic process, lipid metabolic process; MF: N-acetyllactosaminide 3-alpha-galactosyltransferase activity, alpha-1,3-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane, vesicle
Pathways: Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse)
UniProt: Q3V1N9
Entrez ID: 215493
|
Does Knockout of Fbxo8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Fbxo8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxo8 (F-box protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of ARF protein signal transduction, ubiquitin-dependent protein catabolic process; MF: guanyl-nucleotide exchange factor activity
Pathways:
UniProt: Q9QZN3
Entrez ID: 50753
|
Does Knockout of Rnf144a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Rnf144a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rnf144a (ring finger protein 144A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, pattern recognition receptor signaling pathway, protein K6-linked ubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum membrane, membrane, organelle membrane, plasma membrane, ubiquitin ligase complex
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination
UniProt: Q925F3
Entrez ID: 108089
|
Does Knockout of Med1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Med1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Med1 (mediator complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, androgen biosynthetic process, angiogenesis, animal organ morphogenesis, animal organ regeneration, brain development, camera-type eye development, cell morphogenesis, cellular response to epidermal growth factor stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to steroid hormone stimulus, cellular response to thyroid hormone stimulus, embryonic heart tube development, embryonic hemopoiesis, embryonic hindlimb morphogenesis, embryonic placenta development, enucleate erythrocyte development, epithelial cell proliferation involved in mammary gland duct elongation, erythrocyte development, fat cell differentiation, heart development, hematopoietic stem cell differentiation, in utero embryonic development, keratinocyte differentiation, lactation, lens development in camera-type eye, liver development, mRNA transcription by RNA polymerase II, mammary gland branching involved in pregnancy, mammary gland branching involved in thelarche, mammary gland epithelial cell proliferation, megakaryocyte development, monocyte differentiation, negative regulation of apoptotic process, negative regulation of keratinocyte proliferation, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated steroid hormone signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of G0 to G1 transition, positive regulation of cell population proliferation, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of hepatocyte proliferation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type II interferon-mediated signaling pathway, protein import into nucleus, protein ubiquitination, regulation of DNA-templated transcription, regulation of RNA biosynthetic process, regulation of transcription by RNA polymerase II, regulation of vitamin D receptor signaling pathway, retinal pigment epithelium development, thyroid hormone generation, thyroid hormone receptor signaling pathway, transcription by RNA polymerase II, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription factor binding, LBD domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, general transcription initiation factor binding, histone acetyltransferase binding, nuclear estrogen receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, peroxisome proliferator activated receptor binding, promoter-specific chromatin binding, protein binding, protein-containing complex binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, transcription corepressor activity, ubiquitin protein ligase activity; CC: chromatin, core mediator complex, mediator complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ubiquitin ligase complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Regulation of lipid metabolism by PPARalpha, Signal Transduction, Signaling by Nuclear Receptors, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q925J9
Entrez ID: 19014
|
Does Knockout of Scaper in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Scaper
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scaper (S phase cyclin A-associated protein in the ER)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antral ovarian follicle growth, ovarian follicle development, retina development in camera-type eye, seminiferous tubule development, spermatogenesis; MF: molecular_function, nucleic acid binding, zinc ion binding; CC: cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, ooplasm, sperm head
Pathways:
UniProt: F8VQ70, B2RXS3, Q8BIZ8
Entrez ID: 244891
|
Does Knockout of Obsl1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Obsl1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Obsl1 (obscurin-like 1)
Type: protein-coding
Summary: Predicted to be involved in several processes, including positive regulation of dendrite morphogenesis; protein localization to Golgi apparatus; and regulation of mitotic nuclear division. Predicted to be located in Golgi apparatus; centrosome; and perinuclear region of cytoplasm. Predicted to be part of 3M complex. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human OBSL1 (obscurin like cytoskeletal adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, microtubule cytoskeleton organization, positive regulation of dendrite morphogenesis, protein localization to Golgi apparatus, regulation of mitotic nuclear division; CC: 3M complex, Golgi apparatus, centrosome, cytoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: D3YYU8
Entrez ID: 98733
|
Does Knockout of Syt15 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Syt15
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Syt15 (synaptotagmin XV)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of calcium ion-dependent exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding; CC: exocytic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q8C6N3
Entrez ID: 319508
|
Does Knockout of Rps6ka5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Rps6ka5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, negative regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription by RNA polymerase II, post-translational protein modification, protein phosphorylation, regulation of DNA-templated transcription, regulation of postsynapse organization; MF: ATP binding, histone H2AS1 kinase activity, histone H3S10 kinase activity, histone H3S28 kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Axon guidance, Bladder cancer - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CREB phosphorylation, Circadian entrainment - Mus musculus (mouse), Cytokine Signaling in Immune system, Developmental Biology, ERK/MAPK targets, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MicroRNAs in cancer - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NCAM signaling for neurite out-growth, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Nuclear Events (kinase and transcription factor activation), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q8C050
Entrez ID: 73086
|
Does Knockout of Polk in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Polk
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Polk (polymerase (DNA directed), kappa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, cellular response to UV, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, damaged DNA binding, metal ion binding, molecular adaptor activity, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: nuclear body, nucleoplasm, nucleus, site of DNA damage
Pathways: Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Fanconi anemia pathway - Mus musculus (mouse), Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatocellular carcinoma - Mus musculus (mouse), Homology Directed Repair, Melanoma - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Nucleotide Excision Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Termination of translesion DNA synthesis, Thyroid cancer - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional misregulation in cancer - Mus musculus (mouse), Translesion synthesis by POLK, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9QUG2
Entrez ID: 27015
|
Does Knockout of Mill1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Mill1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mill1 (MHC I like leukocyte 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: natural killer cell lectin-like receptor binding, protein binding, receptor ligand activity; CC: cell surface, external side of plasma membrane, extracellular space, membrane, plasma membrane, side of membrane
Pathways:
UniProt: Q8HWE7
Entrez ID: 266815
|
Does Knockout of Camk1g in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Camk1g
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Camk1g (calcium/calmodulin-dependent protein kinase I gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, catalytic activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, calcium- and calmodulin-dependent protein kinase complex, cytoplasm, endomembrane system, membrane, plasma membrane
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: Q91VB2
Entrez ID: 215303
|
Does Knockout of Fjx1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fjx1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fjx1 (four jointed box 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell signaling, retina layer formation; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8BQB4
Entrez ID: 14221
|
Does Knockout of Cadm2 in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Cadm2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cadm2 (cell adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, synaptic membrane adhesion; CC: GABA-ergic synapse, axon, cell projection, glutamatergic synapse, membrane, neuronal cell body membrane, plasma membrane, postsynaptic membrane, synapse
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization
UniProt: Q8BLQ9
Entrez ID: 239857
|
Does Knockout of Lasp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Lasp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lasp1 (LIM and SH3 protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport; MF: actin binding, actin filament binding, metal ion binding, monoatomic ion transmembrane transporter activity, protein binding; CC: cell cortex, cortical actin cytoskeleton, cytoplasm, cytoskeleton, focal adhesion, postsynapse
Pathways:
UniProt: Q61792
Entrez ID: 16796
|
Does Knockout of Clec2h in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Clec2h
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Clec2h (C-type lectin domain family 2, member h)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, natural killer cell lectin-like receptor binding, transmembrane signaling receptor activity; CC: cell surface, endoplasmic reticulum, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q8C1T8
Entrez ID: 94071
|
Does Knockout of Syt13 in Microglial Cell Line causally result in regulation of lipid localization?
| 0
| 1,678
|
Knockout
|
Syt13
|
regulation of lipid localization
|
Microglial Cell Line
|
Gene: Syt13 (synaptotagmin XIII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding; CC: axon, cytoplasmic vesicle, cytoplasmic vesicle membrane, dense core granule, exocytic vesicle, membrane, plasma membrane, synaptic vesicle membrane, transport vesicle
Pathways:
UniProt: Q9EQT6
Entrez ID: 80976
|
Does Knockout of Zfp472 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Zfp472
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp472 (zinc finger protein 472)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B0V2W5, Q3UQI7, A0A3Q4EC37
Entrez ID: 224691
|
Does Knockout of Ptpn23 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Ptpn23
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ptpn23 (protein tyrosine phosphatase, non-receptor type 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, early endosome to late endosome transport, endocytic recycling, negative regulation of epithelial cell migration, positive regulation of Wnt protein secretion, positive regulation of adherens junction organization, positive regulation of early endosome to late endosome transport, positive regulation of homophilic cell adhesion, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein tyrosine phosphatase activity; CC: cell projection, centriolar satellite, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, early endosome, endosome, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q6PB44
Entrez ID: 104831
|
Does Knockout of Tubal3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Tubal3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tubal3 (tubulin, alpha-like 3)
Type: protein-coding
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Orthologous to human TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoskeleton organization, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, hydrolase activity, metal ion binding, nucleotide binding, structural constituent of cytoskeleton; CC: cytoplasm, cytoskeleton, microtubule
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q3UX10
Entrez ID: 238463
|
Does Knockout of Rnpep in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Rnpep
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Rnpep (arginyl aminopeptidase (aminopeptidase B))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of blood pressure, protein processing, proteolysis; MF: aminopeptidase activity, cobalt ion binding, copper ion binding, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, peptide binding, zinc ion binding; CC: external side of plasma membrane, extracellular region, extracellular space, plasma membrane, secretory granule
Pathways:
UniProt: Q8VCT3
Entrez ID: 215615
|
Does Knockout of Scin in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Scin
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Scin (scinderin)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Located in brush border. Is expressed in several structures, including adrenal gland; female reproductive system; gut; hemolymphoid system gland; and metanephros. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament capping, actin filament severing, actin polymerization or depolymerization, barbed-end actin filament capping, cell projection assembly, central nervous system development, negative regulation of cell population proliferation, positive regulation of actin nucleation, positive regulation of apoptotic process, positive regulation of megakaryocyte differentiation, regulation of chondrocyte differentiation; MF: actin binding, actin filament binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding; CC: actin cytoskeleton, anchoring junction, brush border, cell projection, cytoplasm, cytoskeleton, podosome, protein-containing complex
Pathways: Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q60604
Entrez ID: 20259
|
Does Knockout of Tubg1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Tubg1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tubg1 (tubulin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule nucleation, microtubule-based process, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, regulation of mitotic nuclear division; MF: GTP binding, identical protein binding, microtubule nucleator activity, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: apical part of cell, cell leading edge, centriole, centrosome, ciliary basal body, cilium, condensed nuclear chromosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, mitotic spindle microtubule, neuron projection, non-motile cilium, nucleus, pericentriolar material, polar microtubule, recycling endosome, spindle, spindle microtubule, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Human papillomavirus infection - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P83887
Entrez ID: 103733
|
Does Knockout of Gprc5c in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Gprc5c
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gprc5c (G protein-coupled receptor, family C, group 5, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction, visual perception; MF: G protein-coupled receptor activity, protein kinase activator activity, sevenless binding; CC: centriolar satellite, cilium, extracellular exosome, intracellular membrane-bounded organelle, membrane, mitochondrion, plasma membrane, receptor complex
Pathways:
UniProt: Q8K3J9
Entrez ID: 70355
|
Does Knockout of Pdgfb in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Pdgfb
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pdgfb (platelet derived growth factor, B polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, angiogenesis, blood vessel development, blood vessel morphogenesis, branching involved in salivary gland morphogenesis, cardiac vascular smooth muscle cell differentiation, cell chemotaxis, cell projection assembly, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to growth factor stimulus, cellular response to mycophenolic acid, cellular response to platelet-derived growth factor stimulus, embryonic placenta development, epithelial cell proliferation involved in salivary gland morphogenesis, eye photoreceptor cell development, fibroblast migration, gene expression, glial cell development, heart development, hemopoiesis, interleukin-18-mediated signaling pathway, intracellular signal transduction, metanephric glomerular endothelium development, metanephric glomerular mesangial cell development, metanephric glomerular mesangial cell proliferation involved in metanephros development, monocyte chemotaxis, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of miRNA transcription, negative regulation of phosphatidylinositol biosynthetic process, negative regulation of platelet activation, negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of vascular associated smooth muscle cell migration, neuron remodeling, paracrine signaling, peptidyl-tyrosine phosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of DNA biosynthetic process, positive regulation of DNA replication, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAP kinase activity, positive regulation of MAPK cascade, positive regulation of blood vessel endothelial cell migration, positive regulation of calcium ion import, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of chemotaxis, positive regulation of collagen biosynthetic process, positive regulation of endothelial cell proliferation, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of fibroblast migration, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of glomerular filtration, positive regulation of glomerular mesangial cell proliferation, positive regulation of hepatic stellate cell activation, positive regulation of hepatic stellate cell proliferation, positive regulation of hyaluronan biosynthetic process, positive regulation of intracellular signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of metanephric mesenchymal cell migration, positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway, positive regulation of miRNA transcription, positive regulation of mitotic cell cycle, embryonic, positive regulation of mitotic nuclear division, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of reactive oxygen species metabolic process, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of vascular associated smooth muscle cell dedifferentiation, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vasoconstriction, protein phosphorylation, reactive oxygen species metabolic process, regulation of gene expression, regulation of multicellular organismal process, response to wounding, retina development in camera-type eye, retina vasculature development in camera-type eye, substrate-dependent cell migration, synapse assembly, vasoconstriction; MF: chemoattractant activity, collagen binding, growth factor activity, identical protein binding, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein heterodimerization activity, protein homodimerization activity, signaling receptor binding, superoxide-generating NADPH oxidase activator activity; CC: basolateral plasma membrane, cell surface, cytoplasm, dendrite, extracellular region, extracellular space, membrane, neuronal cell body, platelet-derived growth factor complex
Pathways: Calcium signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Downstream signal transduction, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gap junction - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hemostasis, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Prostate cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: P31240
Entrez ID: 18591
|
Does Knockout of Colec12 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Colec12
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Colec12 (collectin sub-family member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to bacterium, immune response, phagocytosis, recognition, plasma membrane raft organization; MF: carbohydrate binding, low-density lipoprotein particle binding, metal ion binding, pattern recognition receptor activity, scavenger receptor activity, signaling receptor activity; CC: collagen trimer, extracellular matrix, membrane
Pathways: Phagosome - Mus musculus (mouse)
UniProt: Q8K4Q8
Entrez ID: 140792
|
Does Knockout of Kif5a in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Kif5a
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Kif5a (kinesin family member 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal protein transport, anterograde dendritic transport of neurotransmitter receptor complex, axon guidance, microtubule-based movement, retrograde neuronal dense core vesicle transport, synaptic vesicle transport, transport along microtubule, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, isomerase activity, kinesin binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding, protein-containing complex binding, scaffold protein binding; CC: P-body, apical dendrite, axon, axon cytoplasm, central region of growth cone, ciliary rootlet, cytoplasm, cytoskeleton, dendrite, dendrite cytoplasm, kinesin complex, microtubule, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, postsynaptic cytosol
Pathways: Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), COPI-dependent Golgi-to-ER retrograde traffic, Dopaminergic synapse - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Non-small cell lung cancer - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: P33175
Entrez ID: 16572
|
Does Knockout of Nono in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,259
|
Knockout
|
Nono
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nono (non-POU-domain-containing, octamer binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, RNA splicing, activation of innate immune response, cellular response to angiotensin, cellular response to hypoxia, circadian rhythm, immune system process, innate immune response, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of DNA-templated transcription, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, identical protein binding, lncRNA binding, nucleic acid binding, protein binding; CC: RNA polymerase II transcription regulator complex, chromosome, fibrillar center, nuclear matrix, nuclear speck, nucleolus, nucleoplasm, nucleus, paraspeckles
Pathways:
UniProt: Q99K48
Entrez ID: 53610
|
Does Knockout of Fv1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Fv1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Fv1 (Friend virus susceptibility 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, response to virus; CC: Golgi apparatus
Pathways:
UniProt: P70213
Entrez ID: 14349
|
Does Knockout of Phax in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Phax
|
response to bacteria
|
renal medulla cell line
|
Gene: Phax (phosphorylated adaptor for RNA export)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA stabilization, protein transport, snRNA export from nucleus; MF: RNA binding, mRNA cap binding complex binding, toxic substance binding; CC: Cajal body, cytoplasm, neuronal cell body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Nucleocytoplasmic transport - Mus musculus (mouse), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9JJT9
Entrez ID: 56698
|
Does Knockout of Vmn1r218 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Vmn1r218
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r218 (vomeronasal 1 receptor 218)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BRZ5, Q8R261
Entrez ID: 171256
|
Does Knockout of Serhl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Serhl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Serhl (serine hydrolase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity; CC: cytoplasm, cytoplasmic vesicle, mitochondrion, perinuclear region of cytoplasm, peroxisome
Pathways:
UniProt: Q9EPB5
Entrez ID: 68607
|
Does Knockout of Sppl3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Sppl3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sppl3 (signal peptide peptidase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, membrane protein ectodomain proteolysis, membrane protein proteolysis, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of cytosolic calcium ion concentration, proteolysis, signal peptide processing; MF: aspartic endopeptidase activity, intramembrane cleaving, hydrolase activity, peptidase activity, protein binding, protein homodimerization activity; CC: Golgi apparatus, Golgi-associated vesicle membrane, cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, lumenal side of endoplasmic reticulum membrane, membrane, organelle membrane, plasma membrane, rough endoplasmic reticulum
Pathways:
UniProt: Q9CUS9
Entrez ID: 74585
|
Does Knockout of Trpc5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Trpc5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Trpc5 (transient receptor potential cation channel, subfamily C, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of dendrite morphogenesis, neuron apoptotic process, neuron differentiation, phosphatidylserine exposure on apoptotic cell surface, positive regulation of axon extension, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of neuron differentiation, regulation of cytosolic calcium ion concentration, regulation of membrane hyperpolarization, transmembrane transport; MF: ATPase binding, actin binding, actinin binding, calcium channel activity, clathrin binding, inositol 1,4,5 trisphosphate binding, metal ion binding, monoatomic ion channel activity, protein binding, store-operated calcium channel activity; CC: calcium channel complex, cation channel complex, dendrite, growth cone, membrane, neuronal cell body, plasma membrane, presynapse
Pathways: Axon guidance - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q9QX29
Entrez ID: 22067
|
Does Knockout of Cdhr3 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Cdhr3
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Cdhr3 (cadherin-related family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8BL00
Entrez ID: 68764
|
Does Knockout of Plekhm3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Plekhm3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Plekhm3 (pleckstrin homology domain containing, family M, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q8BM47
Entrez ID: 241075
|
Does Knockout of Taldo1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Taldo1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Taldo1 (transaldolase 1)
Type: protein-coding
Summary: This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: carbohydrate metabolic process, fructose 6-phosphate metabolic process, glyceraldehyde-3-phosphate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: carbohydrate binding, identical protein binding, monosaccharide binding, protein binding, transaldolase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Insulin effects increased synthesis of Xylulose-5-Phosphate, Integration of energy metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: Q93092
Entrez ID: 21351
|
Does Knockout of Erich1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Erich1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Erich1 (glutamate rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UGP3, E9PY43, A0A1B0GRP9
Entrez ID: 234086
|
Does Knockout of Dusp19 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Dusp19
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dusp19 (dual specificity phosphatase 19)
Type: protein-coding
Summary: Enables several functions, including phosphoprotein phosphatase activity; protein kinase binding activity; and protein kinase regulator activity. Involved in negative regulation of JUN kinase activity; positive regulation of JNK cascade; and positive regulation of JUN kinase activity. Acts upstream of or within JNK cascade; negative regulation of MAPK cascade; and protein dephosphorylation. Located in cytoplasm. Orthologous to human DUSP19 (dual specificity phosphatase 19). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: JNK cascade, negative regulation of JNK cascade, negative regulation of MAPK cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, regulation of JNK cascade; MF: JUN kinase phosphatase activity, MAP-kinase scaffold activity, hydrolase activity, mitogen-activated protein kinase kinase binding, mitogen-activated protein kinase kinase kinase binding, phosphoprotein phosphatase activity, protein binding, protein kinase activator activity, protein kinase inhibitor activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm
Pathways:
UniProt: Q99N12
Entrez ID: 68082
|
Does Knockout of Aldh5a1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Aldh5a1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Aldh5a1 (aldhehyde dehydrogenase family 5, subfamily A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, gamma-aminobutyric acid catabolic process, gamma-aminobutyric acid metabolic process, glutamate metabolic process, post-embryonic development, succinate metabolic process, synaptic transmission, GABAergic; MF: NAD binding, carboxylic acid binding, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, succinate-semialdehyde dehydrogenase (NAD+) activity, succinate-semialdehyde dehydrogenase [NAD(P)+] activity; CC: mitochondrion, synapse
Pathways: 4-aminobutyrate degradation I, 4-aminobutyrate degradation IV, Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Butanoate metabolism - Mus musculus (mouse), Degradation of GABA, GABA synthesis, release, reuptake and degradation, Neuronal System, Neurotransmitter release cycle, Transmission across Chemical Synapses, glutamate degradation III (via 4-aminobutyrate), glutamate degradation IV
UniProt: Q8BWF0
Entrez ID: 214579
|
Does Knockout of Dnajc30 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Dnajc30
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dnajc30 (DnaJ heat shock protein family (Hsp40) member C30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP biosynthetic process, brain development, regulation of mitochondrial ATP synthesis coupled proton transport; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: P59041
Entrez ID: 66114
|
Does Knockout of Xrcc4 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,549
|
Knockout
|
Xrcc4
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DNA damage response, DNA recombination, DNA repair, V(D)J recombination, base-excision repair, central nervous system development, double-strand break repair, double-strand break repair via nonhomologous end joining, immunoglobulin V(D)J recombination, in utero embryonic development, isotype switching, negative regulation of neuron apoptotic process, negative regulation of protection from non-homologous end joining at telomere, positive regulation of fibroblast proliferation, positive regulation of neurogenesis, positive regulation of phosphatidylserine exposure on apoptotic cell surface, pro-B cell differentiation, protein localization to site of double-strand break, response to X-ray, response to gamma radiation, response to ionizing radiation, telomeric DNA-containing double minutes formation; MF: 3' overhang single-stranded DNA endodeoxyribonuclease activity, DNA binding, FHA domain binding, enzyme binding, identical protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, ERCC4-ERCC1 complex, chromosome, chromosome, telomeric region, cytoplasm, cytosol, nonhomologous end joining complex, nucleoplasm, nucleus, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, Metabolism of proteins, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q924T3
Entrez ID: 108138
|
Does Knockout of Yy1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Yy1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Yy1 (YY1 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA recombination, DNA repair, RNA localization, anterior/posterior pattern specification, camera-type eye morphogenesis, cell differentiation, cellular response to UV, cellular response to interleukin-1, chromatin remodeling, chromosome organization, double-strand break repair via homologous recombination, gene expression, hemopoiesis, immunoglobulin heavy chain V-D-J recombination, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of gene expression, negative regulation of interferon-beta production, negative regulation of miRNA transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of transcription by RNA polymerase II, response to UV-C, response to prostaglandin F, spermatogenesis, telomere maintenance; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, four-way junction DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: Ino80 complex, PcG protein complex, chromatin, chromatin silencing complex, cytoplasm, nuclear matrix, nucleoplasm, nucleus, transcription regulator complex
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q00899
Entrez ID: 22632
|
Does Knockout of Gm8267 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Gm8267
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Gm8267 (predicted gene 8267)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: E9Q207, E9PW76
Entrez ID: 666744
|
Does Knockout of Pde7a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pde7a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pde7a (phosphodiesterase 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, negative regulation of cAMP/PKA signal transduction, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P70453
Entrez ID: 18583
|
Does Knockout of Slc38a8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Slc38a8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc38a8 (solute carrier family 38, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, amino acid transmembrane transport, amino acid transport, aspartate metabolic process, neuron projection development, optic nerve development, response to virus, retina development in camera-type eye, retinal pigment epithelium development, viral genome replication, visual perception; CC: axon, cell cortex, cell projection, cellular_component, cytoplasm, membrane
Pathways:
UniProt: Q5HZH7
Entrez ID: 234788
|
Does Knockout of Dkk1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Dkk1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway involved in somitogenesis, cell morphogenesis, embryonic limb morphogenesis, endoderm development, endoderm formation, endodermal cell differentiation, face morphogenesis, forebrain development, hair follicle development, head morphogenesis, heart induction, learning or memory, limb development, mesoderm formation, motor learning, negative regulation of BMP signaling pathway, negative regulation of SMAD protein signal transduction, negative regulation of Wnt signaling pathway, negative regulation of Wnt-Frizzled-LRP5/6 complex assembly, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell differentiation, negative regulation of mesodermal cell fate specification, negative regulation of neuron projection development, negative regulation of ossification, negative regulation of presynapse assembly, negative regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of gene expression, positive regulation of midbrain dopaminergic neuron differentiation, regulation of Wnt signaling pathway, regulation of endodermal cell fate specification, regulation of neuron apoptotic process, regulation of receptor internalization, regulation of synapse organization, regulation of synaptic transmission, glutamatergic, response to retinoic acid, somitogenesis; MF: co-receptor binding, low-density lipoprotein particle receptor binding, protein binding, receptor antagonist activity; CC: extracellular region, extracellular space, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: O54908
Entrez ID: 13380
|
Does Knockout of Csnk1d in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Csnk1d
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Csnk1d (casein kinase 1, delta)
Type: protein-coding
Summary: This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi organization, Wnt signaling pathway, circadian regulation of gene expression, endocytosis, microtubule nucleation, midbrain dopaminergic neuron differentiation, non-motile cilium assembly, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein localization to Golgi apparatus, protein localization to centrosome, protein localization to cilium, protein phosphorylation, regulation of circadian rhythm, rhythmic process, signal transduction, spindle assembly; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity, transferase activity; CC: Golgi apparatus, actin cytoskeleton, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, Circadian rhythm - Mus musculus (mouse), ER to Golgi Anterograde Transport, G2/M Transition, Gap junction - Mus musculus (mouse), Hedgehog signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Membrane Trafficking, Metabolism of RNA, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DC28
Entrez ID: 104318
|
Does Knockout of Slc25a4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Slc25a4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc25a4 (solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, adaptive thermogenesis, apoptotic mitochondrial changes, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitochondrial membrane permeability involved in apoptotic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, negative regulation of necroptotic process, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of mitophagy, proton transmembrane transport, regulation of mitochondrial membrane permeability, transmembrane transport; MF: ATP:ADP antiporter activity, antiporter activity, enzyme binding, oxidative phosphorylation uncoupler activity, protein binding, proton transmembrane transporter activity; CC: membrane, membrane raft, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrial permeability transition pore complex, mitochondrion, myelin sheath
Pathways: Alzheimer disease - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), creatine-phosphate energy transfer
UniProt: P48962
Entrez ID: 11739
|
Does Knockout of Hsf3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Hsf3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hsf3 (heat shock transcription factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to heat, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, chromatin DNA binding, sequence-specific DNA binding; CC: cytoplasm, nucleus
Pathways:
UniProt: D0VYS2
Entrez ID: 245525
|
Does Knockout of Sin3a in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sin3a
|
cell proliferation
|
Regulatory T cell
|
Gene: Sin3a (transcriptional regulator, SIN3A (yeast))
Type: protein-coding
Summary: Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in several processes, including cerebral cortex neuron differentiation; negative regulation of circadian rhythm; and regulation of axon extension. Acts upstream of or within several processes, including cellular response to glucose stimulus; positive regulation of G2/M transition of mitotic cell cycle; and response to methylglyoxal. Located in kinetochore and nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; pancreas; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA replication, activation of innate immune response, cellular response to dopamine, cellular response to glucose stimulus, cellular response to tert-butyl hydroperoxide, cerebral cortex neuron differentiation, hematopoietic progenitor cell differentiation, heterochromatin formation, in utero embryonic development, intracellular protein localization, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of circadian rhythm, negative regulation of protein localization to nucleus, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of defense response to virus by host, positive regulation of neuron differentiation, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of axon extension, regulation of cell cycle, regulation of hormone levels, response to methylglyoxal, rhythmic process, type I interferon-mediated signaling pathway; MF: DNA binding, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, protein-containing complex binding, transcription corepressor activity, transcription regulator inhibitor activity; CC: Sin3-type complex, chromatin, chromosome, histone deacetylase complex, kinetochore, nucleolus, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex, transcription repressor complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Developmental Biology, Epstein-Barr virus infection - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of MECP2 expression and activity, Regulation of MITF-M-dependent genes involved in apoptosis, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of lipid metabolism by PPARalpha, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by MECP2, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q60520
Entrez ID: 20466
|
Does Knockout of Paf1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Paf1
|
cell cycle progression
|
breast epithelium
|
Gene: Paf1 (Paf1, RNA polymerase II complex component)
Type: protein-coding
Summary: Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Part of Cdc73/Paf1 complex. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of cell cycle G1/S phase transition, positive regulation of transcription by RNA polymerase II, protein localization to nucleus, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, chromatin binding, protein binding; CC: Cdc73/Paf1 complex, cytoplasm, fibrillar center, membrane, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q8K2T8
Entrez ID: 54624
|
Does Knockout of Rock2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Rock2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, actomyosin structure organization, blood vessel diameter maintenance, cellular response to acetylcholine, centrosome duplication, cortical actin cytoskeleton organization, dendrite morphogenesis, embryonic morphogenesis, epithelial to mesenchymal transition, extrinsic apoptotic signaling pathway via death domain receptors, host-mediated perturbation of viral process, mRNA destabilization, mitotic cytokinesis, negative regulation of angiogenesis, negative regulation of bicellular tight junction assembly, negative regulation of gene expression, negative regulation of nitric oxide biosynthetic process, negative regulation of protein localization to lysosome, neural tube closure, positive regulation of MAPK cascade, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of cardiac muscle hypertrophy, positive regulation of cell migration, positive regulation of centrosome duplication, positive regulation of connective tissue growth factor production, positive regulation of connective tissue replacement, positive regulation of fibroblast growth factor production, positive regulation of gene expression, positive regulation of protein localization to early endosome, positive regulation of stress fiber assembly, postsynaptic actin cytoskeleton organization, protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of angiotensin-activated signaling pathway, regulation of cell junction assembly, regulation of cellular response to hypoxia, regulation of circadian rhythm, regulation of establishment of endothelial barrier, regulation of keratinocyte differentiation, regulation of nervous system process, regulation of synapse maturation, response to angiotensin, response to ischemia, response to transforming growth factor beta, rhythmic process, signal transduction, smooth muscle contraction, stress fiber assembly; MF: ATP binding, Rho-dependent protein serine/threonine kinase activity, endopeptidase activator activity, kinase activity, metal ion binding, nucleotide binding, protease binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, centrosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, glutamatergic synapse, membrane, neuromuscular junction, nucleus, plasma membrane, postsynaptic density, presynaptic active zone, spindle pole centrosome
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Focal adhesion - Mus musculus (mouse), G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Nervous system development, Oxytocin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate ROCKs, RHOA GTPase cycle, RHOB GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOC GTPase cycle, RHOH GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Vascular smooth muscle contraction - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P70336
Entrez ID: 19878
|
Does Knockout of Rai14 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rai14
|
cell cycle progression
|
breast epithelium
|
Gene: Rai14 (retinoic acid induced 14)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; jaw; neural ectoderm; and retina. Orthologous to human RAI14 (retinoic acid induced 14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: anchoring junction, cell cortex, cytoplasm, cytoskeleton, cytosol, fibrillar center, mitochondrion, nucleoplasm, nucleus, stress fiber
Pathways:
UniProt: Q9EP71
Entrez ID: 75646
|
Does Knockout of Kctd12b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Kctd12b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kctd12b (potassium channel tetramerisation domain containing 12b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, protein homooligomerization, regulation of G protein-coupled receptor signaling pathway, regulation of presynaptic membrane potential; MF: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; CC: GABA-ergic synapse, presynaptic active zone membrane, presynaptic membrane, receptor complex
Pathways:
UniProt: Q8C7J6
Entrez ID: 207474
|
Does Knockout of Bcs1l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Bcs1l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Bcs1l (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone)
Type: protein-coding
Summary: The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex III assembly, mitochondrion organization, protein insertion into mitochondrial inner membrane from matrix, protein transmembrane transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, mitochondrial protein-transporting ATPase activity, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CZP5
Entrez ID: 66821
|
Does Knockout of Itga2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Itga2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Itga2 (integrin alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, cellular response to estradiol stimulus, cellular response to mechanical stimulus, collagen-activated signaling pathway, detection of mechanical stimulus involved in sensory perception of pain, female pregnancy, focal adhesion assembly, hepatocyte differentiation, hypotonic response, integrin-mediated signaling pathway, mammary gland development, mesodermal cell differentiation, positive regulation of cell adhesion, positive regulation of cell projection organization, positive regulation of collagen biosynthetic process, positive regulation of epithelial cell migration, positive regulation of leukocyte migration, positive regulation of phagocytosis, engulfment, positive regulation of positive chemotaxis, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of smooth muscle contraction, positive regulation of translation, positive regulation of transmission of nerve impulse, response to L-ascorbic acid, response to amine, response to hypoxia, response to muscle activity, response to parathyroid hormone, response to xenobiotic stimulus, skin morphogenesis, substrate-dependent cell migration; MF: amyloid-beta binding, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity, integrin binding, laminin binding, metal ion binding, protein-containing complex binding, signaling receptor activity; CC: axon, axon terminus, basal part of cell, cell projection, cell surface, external side of plasma membrane, focal adhesion, integrin alpha2-beta1 complex, integrin complex, membrane, perinuclear region of cytoplasm, plasma membrane, presynapse
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse), Syndecan interactions
UniProt: Q62469
Entrez ID: 16398
|
Does Knockout of Cplx4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cplx4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cplx4 (complexin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, modulation of chemical synaptic transmission, neurotransmitter transport, regulation of neurotransmitter secretion, regulation of synaptic vesicle fusion to presynaptic active zone membrane, synaptic vesicle exocytosis, visual perception; MF: SNARE binding, syntaxin binding; CC: SNARE complex, membrane, plasma membrane, synapse, terminal bouton
Pathways: Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q80WM3
Entrez ID: 225644
|
Does Knockout of Ankrd23 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ankrd23
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ankrd23 (ankyrin repeat domain 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, positive regulation of transcription by RNA polymerase II, regulation of sarcomere organization, response to mechanical stimulus, response to muscle stretch; MF: titin binding, transcription cis-regulatory region binding; CC: I band, actin cytoskeleton, cytosol, intercalated disc, myofibril, nucleoplasm, nucleus
Pathways:
UniProt: Q812A3
Entrez ID: 78321
|
Does Knockout of Cd79b in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Cd79b
|
cell cycle progression
|
breast epithelium
|
Gene: Cd79b (CD79B antigen)
Type: protein-coding
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: B cell differentiation, B cell receptor signaling pathway, adaptive immune response, cell surface receptor signaling pathway, immune system process, response to bacterium, signal transduction; MF: identical protein binding, protein binding, transmembrane signaling receptor activity; CC: B cell receptor complex, IgM B cell receptor complex, external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), CD22 mediated BCR regulation, Immune System, Signaling by the B Cell Receptor (BCR)
UniProt: P15530
Entrez ID: 15985
|
Does Knockout of Smim7 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Smim7
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Smim7 (small integral membrane protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5RKS2
Entrez ID: 66818
|
Does Knockout of Uqcc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Uqcc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Uqcc1 (ubiquinol-cytochrome c reductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly; CC: cytoplasmic vesicle, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CWU6
Entrez ID: 56046
|
Does Knockout of Tmem248 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Tmem248
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem248 (transmembrane protein 248)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3TBN1
Entrez ID: 71667
|
Does Knockout of Ankrd61 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Ankrd61
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ankrd61 (ankyrin repeat domain 61)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, molecular_function; CC: nucleoplasm
Pathways:
UniProt: Q9CQM6
Entrez ID: 66729
|
Does Knockout of Card9 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Card9
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Card9 (caspase recruitment domain family, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antifungal innate immune response, apoptotic signaling pathway, defense response to Gram-positive bacterium, defense response to virus, host-mediated modulation of intestinal microbiota composition, immune system process, immunoglobulin mediated immune response, innate immune response, neutrophil mediated immunity, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of T-helper 17 type immune response, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of cytokine production involved in inflammatory response, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of innate immune response, positive regulation of interleukin-17 production, positive regulation of interleukin-6 production, positive regulation of macrophage cytokine production, positive regulation of stress-activated MAPK cascade, positive regulation of tumor necrosis factor production, protein homooligomerization, regulation of apoptotic process, regulation of immune response, regulation of interleukin-2 production, regulation of interleukin-6 production, regulation of tumor necrosis factor production, response to aldosterone, response to exogenous dsRNA, response to fungus, response to muramyl dipeptide, response to peptidoglycan, response to xenobiotic stimulus; MF: CARD domain binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, signaling adaptor activity; CC: CBM complex, cytoplasm, cytosol, protein-containing complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Herpes simplex virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: A2AIV8
Entrez ID: 332579
|
Does Knockout of Insc in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Insc
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Insc (INSC spindle orientation adaptor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apical protein localization, asymmetric cell division, cell differentiation, nervous system development, regulation of asymmetric cell division, regulation of protein stability; MF: cytoskeletal anchor activity, protein domain specific binding, protein-macromolecule adaptor activity; CC: apical cortex, cell cortex, cytoplasm, plasma membrane, protein-containing complex
Pathways:
UniProt: Q3HNM7
Entrez ID: 233752
|
Does Knockout of Nwd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Nwd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nwd2 (NACHT and WD repeat domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, synapse
Pathways:
UniProt: Q6P5U7
Entrez ID: 319807
|
Does Knockout of Zranb3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zranb3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zranb3 (zinc finger, RAN-binding domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, replication fork processing, replication fork reversal, response to UV; MF: ATP binding, ATP-dependent DNA/DNA annealing activity, DNA endonuclease activity, DNA helicase activity, K63-linked polyubiquitin modification-dependent protein binding, catalytic activity, endonuclease activity, helicase activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, zinc ion binding; CC: chromosome, nuclear replication fork, nucleoplasm, nucleus
Pathways:
UniProt: Q6NZP1
Entrez ID: 226409
|
Does Knockout of Gnal in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Gnal
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Gnal (guanine nucleotide binding protein, alpha stimulating, olfactory type)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, cellular response to dopamine, regulation of long-term synaptic depression, response to amphetamine, response to caffeine, sensory perception of chemical stimulus, sensory perception of smell, signal transduction; MF: G protein activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding; CC: acrosomal vesicle, apical cytoplasm, ciliary necklace, cilium, cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane, sperm midpiece
Pathways: Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Amoebiasis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), G alpha (i) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GPCR downstream signalling, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory Signaling Pathway, Olfactory transduction - Mus musculus (mouse), Opioid Signalling, Parkinson disease - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, Transmission across Chemical Synapses
UniProt: Q8CGK7
Entrez ID: 14680
|
Does Knockout of Pcdhb21 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Pcdhb21
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcdhb21 (protocadherin beta 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91V48
Entrez ID: 93892
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