prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Bsdc1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Bsdc1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Bsdc1 (BSD domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80Y55
Entrez ID: 100383
|
Does Knockout of Glyctk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Glyctk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Glyctk (glycerate kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fructose catabolic process, protein phosphorylation; MF: ATP binding, glycerate kinase activity, kinase activity, nucleotide binding, transferase activity; CC: Golgi apparatus, cytoplasm, cytosol, mitochondrion
Pathways: Fructose catabolism, Fructose metabolism, Glycerolipid metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway - Mus musculus (mouse)
UniProt: Q8QZY2
Entrez ID: 235582
|
Does Knockout of Scarb1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Scarb1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Scarb1 (scavenger receptor class B, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adhesion of symbiont to host, androgen biosynthetic process, blood vessel endothelial cell migration, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol import, cholesterol transport, detection of lipopolysaccharide, endothelial cell proliferation, high density lipoprotein particle mediated signaling, high-density lipoprotein particle clearance, high-density lipoprotein particle remodeling, intestinal lipid absorption, lipid transport, lipopolysaccharide transport, lipopolysaccharide-mediated signaling pathway, low-density lipoprotein particle clearance, phagocytosis, recognition, phospholipid transport, plasma lipoprotein particle clearance, positive regulation of cholesterol storage, positive regulation of nitric oxide mediated signal transduction, positive regulation of sphingolipid mediated signaling pathway, positive regulation of triglyceride biosynthetic process, recognition of apoptotic cell, regulation of phagocytosis, regulation of phosphatidylcholine catabolic process, reverse cholesterol transport, triglyceride homeostasis, vasodilation, vitamin transmembrane transport; MF: amyloid-beta binding, apolipoprotein A-I binding, apolipoprotein binding, high-density lipoprotein particle binding, high-density lipoprotein particle receptor activity, identical protein binding, lipid binding, lipopolysaccharide binding, lipopolysaccharide immune receptor activity, low-density lipoprotein particle binding, phosphatidylserine binding, protein binding, scavenger receptor activity; CC: caveola, cell surface, cytoplasm, lysosome, membrane, microvillus membrane, plasma membrane
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Binding and Uptake of Ligands by Scavenger Receptors, Cholesterol metabolism - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), HDL clearance, Hepatitis C - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Scavenging by Class B Receptors, Transport of small molecules, Vesicle-mediated transport, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q61009
Entrez ID: 20778
|
Does Knockout of Plk2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Plk2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Plk2 (polo like kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, Rap protein signal transduction, Ras protein signal transduction, long-term synaptic depression, long-term synaptic potentiation, memory, mitotic cell cycle, mitotic spindle organization, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of apoptotic process in bone marrow cell, negative regulation of cellular senescence, negative regulation of dendritic spine development, negative regulation of excitatory postsynaptic potential, negative regulation of protein localization to cell surface, positive regulation of autophagy, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, positive regulation of receptor internalization, protein phosphorylation, regulation of centriole replication, regulation of synaptic plasticity, regulation protein catabolic process at postsynapse; MF: ATP binding, ATP-dependent protein binding, ATPase binding, GTPase binding, clathrin heavy chain binding, kinase activity, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: cell projection, centriole, centrosome, chromatin, cytoplasm, cytoskeleton, dendrite, kinetochore, nucleoplasm, nucleus, postsynapse, spindle pole
Pathways: FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: P53351
Entrez ID: 20620
|
Does Knockout of Bsn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Bsn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bsn (bassoon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axo-dendritic transport, maintenance of presynaptic active zone structure, modulation of chemical synaptic transmission, presynaptic active zone assembly, presynaptic active zone organization, protein localization to synapse, regulation of synaptic vesicle cycle, retrograde axonal transport, synapse organization, synaptic vesicle clustering; MF: dynein light chain binding, enzyme inhibitor activity, metal ion binding, protein binding, structural constituent of presynaptic active zone, transcription corepressor binding, zinc ion binding; CC: GABA-ergic synapse, Golgi-associated vesicle, Schaffer collateral - CA1 synapse, axon, axon cytoplasm, cell cortex, cell projection, cell surface, cochlear hair cell ribbon synapse, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytoskeleton of presynaptic active zone, cytosol, dendrite, excitatory synapse, extrinsic component of membrane, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, inhibitory synapse, neuron projection terminus, neuronal cell body, organelle, piccolo-bassoon transport vesicle, postsynaptic density, presynapse, presynaptic active zone, presynaptic active zone cytoplasmic component, ribbon synapse, synapse, synaptic membrane, synaptic vesicle, trans-Golgi network
Pathways:
UniProt: O88737
Entrez ID: 12217
|
Does Knockout of Mmachc in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Mmachc
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mmachc (methylmalonic aciduria cblC type, with homocystinuria)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cobalamin metabolic process, demethylation, glutathione metabolic process; MF: FAD binding, cobalamin binding, cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity, demethylase activity, glutathione binding, oxidoreductase activity, protein homodimerization activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasm, cytosol, mitochondrion
Pathways: Cobalamin (Cbl) metabolism, Cobalamin (Cbl, vitamin B12) transport and metabolism, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q9CZD0
Entrez ID: 67096
|
Does Knockout of Mir466b-3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Mir466b-3
|
cell cycle progression
|
breast epithelium
|
Gene: Mir466b-3 (microRNA 466b-3)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to estrogen stimulus, cellular response to forskolin, regulation of gene expression
Pathways:
UniProt:
Entrez ID: 100124474
|
Does Knockout of Hectd3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Hectd3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hectd3 (HECT domain E3 ubiquitin protein ligase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: syntaxin binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q3U487
Entrez ID: 76608
|
Does Knockout of Zmiz2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Zmiz2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zmiz2 (zinc finger, MIZ-type containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein sumoylation, regulation of transcription by RNA polymerase II; MF: SUMO ligase activity, metal ion binding, transcription coactivator activity, zinc ion binding; CC: chromatin, mitochondrion, nuclear replication fork, nucleoplasm, nucleus
Pathways:
UniProt: Q8CIE2
Entrez ID: 52915
|
Does Knockout of Slc35f2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Slc35f2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc35f2 (solute carrier family 35, member F2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, transmembrane transport; MF: molecular_function, transmembrane transporter activity; CC: cellular_component, membrane
Pathways:
UniProt: Q7TML3
Entrez ID: 72022
|
Does Knockout of Cfdp1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Cfdp1
|
phagocytosis
|
macrophage
|
Gene: Cfdp1 (craniofacial development protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, chromatin remodeling, negative regulation of fibroblast apoptotic process, regulation of cell population proliferation, regulation of cell shape; CC: Swr1 complex, basement membrane, chromosome, chromosome, centromeric region, kinetochore
Pathways:
UniProt: O88271
Entrez ID: 23837
|
Does Knockout of Tmem269 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Tmem269
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem269 (transmembrane protein 269)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D4Y8
Entrez ID: 75180
|
Does Knockout of Glp1r in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Glp1r
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Glp1r (glucagon-like peptide 1 receptor)
Type: protein-coding
Summary: Predicted to enable glucagon receptor activity; glucagon-like peptide 1 receptor activity; and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure; and response to psychosocial stress. Acts upstream of or within with a positive effect on hormone secretion. Acts upstream of or within post-translational protein targeting to membrane, translocation. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, associative learning, cAMP/PKA signal transduction, cell surface receptor signaling pathway, cellular response to glucagon stimulus, feeding behavior, hormone secretion, insulin secretion, learning or memory, memory, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of neuron apoptotic process, neuropeptide signaling pathway, positive regulation of blood pressure, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, post-translational protein targeting to membrane, translocation, protein transport, regulation of calcium ion transport, regulation of heart contraction, release of sequestered calcium ion into cytosol, response to glucose, response to psychosocial stress, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, glucagon receptor activity, glucagon-like peptide 1 receptor activity, peptide hormone binding, peptide receptor activity, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Metabolism, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of insulin secretion, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: O35659
Entrez ID: 14652
|
Does Knockout of Coq10a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Coq10a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Coq10a (coenzyme Q10A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport
UniProt: A0A1W2P7G5, E9Q3H6, A0A1W2P7J1, A0A1W2P732, A0A1W2P8D4
Entrez ID: 210582
|
Does Knockout of Xpot in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Xpot
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Xpot (exportin, tRNA (nuclear export receptor for tRNAs))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, tRNA export from nucleus, tRNA re-export from nucleus; MF: RNA binding, small GTPase binding, tRNA binding; CC: cytoplasm, cytosol, nuclear matrix, nuclear pore, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9CRT8
Entrez ID: 73192
|
Does Knockout of Cdrt4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cdrt4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdrt4 (CMT1A duplicated region transcript 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA64
Entrez ID: 66338
|
Does Knockout of Angpt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Angpt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Angpt1 (angiopoietin 1)
Type: protein-coding
Summary: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013].
Gene Ontology: BP: Tie signaling pathway, angiogenesis, blood coagulation, branching involved in blood vessel morphogenesis, cardiac muscle tissue morphogenesis, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, cell-substrate adhesion, endocardium morphogenesis, endoderm development, glomerulus vasculature development, hemopoiesis, heparin proteoglycan biosynthetic process, in utero embryonic development, negative regulation of apoptotic process, negative regulation of blood coagulation, negative regulation of cell adhesion, negative regulation of cytokine production involved in immune response, negative regulation of endothelial cell apoptotic process, negative regulation of neuron apoptotic process, negative regulation of protein import into nucleus, negative regulation of vascular endothelial growth factor signaling pathway, negative regulation of vascular permeability, ovarian follicle development, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of blood vessel endothelial cell migration, positive regulation of blood-brain barrier permeability, positive regulation of cell adhesion, positive regulation of coagulation, positive regulation of endothelial cell migration, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein ubiquitination, positive regulation of receptor internalization, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein localization to cell surface, regulation of canonical NF-kappaB signal transduction, regulation of macrophage migration inhibitory factor signaling pathway, regulation of skeletal muscle satellite cell proliferation, regulation of tumor necrosis factor production, sprouting angiogenesis, vasculogenesis, vasculogenesis involved in coronary vascular morphogenesis; MF: identical protein binding, protein binding, receptor ligand activity, receptor tyrosine kinase binding, signaling receptor binding, vascular endothelial growth factor receptor binding; CC: extracellular matrix, extracellular region, extracellular space, membrane raft, microvillus, plasma membrane
Pathways: Cell surface interactions at the vascular wall, HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Tie2 Signaling
UniProt: O08538
Entrez ID: 11600
|
Does Knockout of Ppp3cc in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ppp3cc
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcineurin-NFAT signaling cascade, calcineurin-mediated signaling, negative regulation of calcium ion import across plasma membrane, penetration of zona pellucida, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of calcium ion import across plasma membrane, positive regulation of synaptic vesicle endocytosis, regulation of synaptic vesicle endocytosis; MF: calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, calmodulin-dependent protein phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: calcineurin complex, cytoplasm, cytosol, glutamatergic synapse, mitochondrion, presynapse, presynaptic cytosol, protein serine/threonine phosphatase complex, sperm flagellum, sperm midpiece, sperm mitochondrial sheath
Pathways: Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P48455
Entrez ID: 19057
|
Does Knockout of Ssr3 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Ssr3
|
phagocytosis
|
macrophage
|
Gene: Ssr3 (signal sequence receptor, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9DCF9
Entrez ID: 67437
|
Does Knockout of Slf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Slf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slf2 (SMC5-SMC6 complex localization factor 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in PML body and chromatin. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SLF2 (SMC5-SMC6 complex localization factor 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, DNA repair, positive regulation of double-strand break repair, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of protein-containing complex assembly, protein localization to site of double-strand break; MF: protein-containing complex binding, ubiquitin protein ligase binding; CC: PML body, chromatin, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q3UH46, E9Q839
Entrez ID: 226151
|
Does Knockout of Uso1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Uso1
|
phagocytosis
|
macrophage
|
Gene: Uso1 (USO1 vesicle docking factor)
Type: protein-coding
Summary: Acts upstream of or within several processes, including Golgi organization; regulation of cellular response to insulin stimulus; and small GTPase-mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, Golgi vesicle docking, Golgi vesicle transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, membrane fusion, protein transport, regulation of cellular response to insulin stimulus, secretory granule localization, small GTPase-mediated signal transduction, transcytosis, vesicle fusion with Golgi apparatus, vesicle-mediated transport; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, Golgi stack, cytoplasm, cytosol, endoplasmic reticulum, fibrillar center, membrane, perinuclear region of cytoplasm
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Z1Z0
Entrez ID: 56041
|
Does Knockout of Rplp0 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Rplp0
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Rplp0 (ribosomal protein lateral stalk subunit P0)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, ribosome biogenesis; MF: large ribosomal subunit rRNA binding, peptide binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, endoplasmic reticulum, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14869
Entrez ID: 11837
|
Does Knockout of Tex21 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tex21
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tex21 (testis expressed gene 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9R0U9, Q497Q3, Q9D4K1, A0A1W2P825
Entrez ID: 80384
|
Does Knockout of Tmem88 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Tmem88
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem88 (transmembrane protein 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, protein localization to plasma membrane, protein stabilization; MF: PDZ domain binding, protein binding; CC: cytosol, membrane, plasma membrane
Pathways:
UniProt: Q9D0N8
Entrez ID: 67020
|
Does Knockout of Tnks1bp1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Tnks1bp1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Tnks1bp1 (tankyrase 1 binding protein 1)
Type: protein-coding
Summary: Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in adherens junction; cytoplasm; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to ionizing radiation, double-strand break repair; MF: ankyrin repeat binding, enzyme binding, protein serine/threonine kinase activator activity, protein-containing complex binding; CC: CCR4-NOT complex, adherens junction, chromosome, cytoplasm, cytoskeleton, cytosol, heterochromatin, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: P58871
Entrez ID: 228140
|
Does Knockout of C1rb in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
C1rb
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: C1rb (complement component 1, r subcomponent B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, classical pathway, immune system process, innate immune response, killing of cells of another organism, opsonization, protein maturation, proteolysis, zymogen activation; MF: calcium ion binding, hydrolase activity, identical protein binding, metal ion binding, molecular sequestering activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: blood microparticle, cell surface, complement component C1 complex, extracellular region, extracellular space, symbiont cell surface
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: Q8CFG9
Entrez ID: 667277
|
Does Knockout of Ptges2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ptges2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ptges2 (prostaglandin E synthase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cyclooxygenase pathway, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, positive regulation of DNA-templated transcription, prostaglandin biosynthetic process, prostaglandin metabolic process, secretion; MF: 12-hydroxyheptadecatrienoic acid synthase activity, DNA binding, glutathione binding, heme binding, isomerase activity, lyase activity, prostaglandin-E synthase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, membrane, mitochondrion, nucleus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Fatty acid metabolism, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), biosynthesis of prostaglandins
UniProt: Q8BWM0
Entrez ID: 96979
|
Does Knockout of Zdhhc12 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Zdhhc12
|
response to bacteria
|
renal medulla cell line
|
Gene: Zdhhc12 (zinc finger, DHHC domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated autophagy, gamma-aminobutyric acid receptor clustering, gephyrin clustering involved in postsynaptic density assembly, negative regulation of NLRP3 inflammasome complex assembly, peptidyl-L-cysteine S-palmitoylation, positive regulation of synaptic transmission, GABAergic, protein catabolic process, protein targeting to lysosome involved in chaperone-mediated autophagy, protein targeting to membrane, synaptic transmission, GABAergic; MF: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8VC90
Entrez ID: 66220
|
Does Knockout of Sod2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Sod2
|
response to bacteria
|
renal medulla cell line
|
Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular response to oxidative stress, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, intracellular oxygen homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, liver development, locomotory behavior, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of membrane hyperpolarization, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of vascular associated smooth muscle cell proliferation, neuron development, positive regulation of cell migration, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, post-embryonic development, protein homotetramerization, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to L-ascorbic acid, response to activity, response to axon injury, response to cadmium ion, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to immobilization stress, response to isolation stress, response to lipopolysaccharide, response to magnetism, response to manganese ion, response to nutrient levels, response to oxidative stress, response to oxygen levels, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to superoxide, response to xenobiotic stimulus, response to zinc ion, superoxide anion generation, superoxide metabolic process, vasodilation; MF: DNA binding, enzyme binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, FoxO signaling pathway - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Mitochondrial biogenesis, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, superoxide radicals degradation
UniProt: P09671
Entrez ID: 20656
|
Does Knockout of Nemp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Nemp2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nemp2 (nuclear envelope integral membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q8CB65
Entrez ID: 227094
|
Does Knockout of Kat6a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Kat6a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kat6a (K(lysine) acetyltransferase 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta morphogenesis, cellular senescence, chromatin organization, embryonic hemopoiesis, face morphogenesis, heart morphogenesis, myeloid cell differentiation, negative regulation of DNA-templated transcription, nucleosome assembly, positive regulation of DNA-templated transcription, positive regulation of gene expression, protein acetylation, regulation of DNA-templated transcription, regulation of developmental process, regulation of hemopoiesis, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: DNA binding, DNA-binding transcription factor binding, acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone H3K14 acetyltransferase activity, histone H3K9 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, protein binding, protein-lysine-acetyltransferase activity, transcription coactivator activity, transcription coregulator activity, transferase activity, zinc ion binding; CC: MOZ/MORF histone acetyltransferase complex, PML body, chromatin, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleosome, nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: A0A5F8MPX1, G3X940
Entrez ID: 244349
|
Does Knockout of Map3k13 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Map3k13
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Map3k13 (mitogen-activated protein kinase kinase kinase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, positive regulation of axon extension, positive regulation of branching morphogenesis of a nerve, positive regulation of neuron maturation, positive regulation of neuron projection arborization, stress-activated MAPK cascade; MF: ATP binding, IkappaB kinase complex binding, MAP kinase kinase kinase activity, enzyme binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, membrane
Pathways: MAPK signaling pathway - Mus musculus (mouse)
UniProt: Q1HKZ5
Entrez ID: 71751
|
Does Knockout of Senp7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Senp7
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Senp7 (SUMO1/sentrin specific peptidase 7)
Type: protein-coding
Summary: This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: antiviral innate immune response, immune system process, innate immune response, protein desumoylation, proteolysis; MF: SUMO-specific endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways:
UniProt: Q8BUH8
Entrez ID: 66315
|
Does Knockout of Vwde in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Vwde
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vwde (von Willebrand factor D and EGF domains)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q6DFV8
Entrez ID: 232585
|
Does Knockout of Hnf4a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Hnf4a
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hnf4a (hepatic nuclear factor 4, alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: acyl-CoA metabolic process, blood coagulation, cell differentiation, cell-cell junction organization, cholesterol homeostasis, establishment of tissue polarity, gene expression, glucose homeostasis, intracellular receptor signaling pathway, lipid homeostasis, lipid metabolic process, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of mitotic cell cycle, negative regulation of protein import into nucleus, phospholipid homeostasis, positive regulation of DNA-templated transcription, positive regulation of fatty acid biosynthetic process, positive regulation of gene expression, positive regulation of gluconeogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of circadian rhythm, regulation of gastrulation, regulation of insulin secretion, regulation of lipid metabolic process, regulation of microvillus assembly, regulation of ornithine metabolic process, regulation of transcription by RNA polymerase II, response to glucose, response to trichostatin A, rhythmic process, sex differentiation, signal transduction involved in regulation of gene expression, triglyceride homeostasis, xenobiotic metabolic process; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, arachidonate binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, fatty acid binding, fatty-acyl-CoA binding, long-chain fatty acyl-CoA binding, long-chain fatty acyl-CoA hydrolase activity, metal ion binding, nuclear receptor activity, protein binding, protein domain specific binding, protein homodimerization activity, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, signaling receptor binding, stearic acid binding, transcription cis-regulatory region binding, transcription coregulator binding, transcription corepressor binding, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Maturity onset diabetes of the young - Mus musculus (mouse), Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: P49698
Entrez ID: 15378
|
Does Knockout of Nlrp4c in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Nlrp4c
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Nlrp4c (NLR family, pyrin domain containing 4C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, biological_process, inflammatory response, negative regulation of innate immune response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K33-linked deubiquitination, protein K48-linked ubiquitination, regulation of inflammatory response; MF: ATP binding, molecular adaptor activity, molecular_function, nucleotide binding; CC: cytoplasm
Pathways: Cytosolic sensors of pathogen-associated DNA , IRF3-mediated induction of type I IFN, Immune System, Innate Immune System, Regulation of innate immune responses to cytosolic DNA, STING mediated induction of host immune responses
UniProt: Q3TKR3
Entrez ID: 83564
|
Does Knockout of Mex3b in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Mex3b
|
response to bacteria
|
renal medulla cell line
|
Gene: Mex3b (mex3 RNA binding family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, positive regulation of cell-cell adhesion, positive regulation of phagocytosis, protein localization to cell cortex; MF: GTPase activating protein binding, RNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: F8WJD6
Entrez ID: 108797
|
Does Knockout of Pet117 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Pet117
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pet117 (PET117 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: P0DJF2
Entrez ID: 100048644
|
Does Knockout of Herc4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Herc4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Herc4 (hect domain and RLD 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of smoothened signaling pathway, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, fibrillar center
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q6PAV2
Entrez ID: 67345
|
Does Knockout of Gatad1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Gatad1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gatad1 (GATA zinc finger domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, regulation of DNA-templated transcription, regulation of gene expression; MF: metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q920S3
Entrez ID: 67210
|
Does Knockout of Nme6 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Nme6
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Nme6 (NME/NM23 nucleoside diphosphate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CTP biosynthetic process, GTP biosynthetic process, UTP biosynthetic process, negative regulation of cell growth, negative regulation of mitotic nuclear division, nucleotide metabolic process, pyrimidine ribonucleotide salvage; MF: ATP binding, kinase activity, metal ion binding, nucleoside diphosphate kinase activity, nucleotide binding, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I, pyrimidine ribonucleotides <i>de novo</i> biosynthesis, pyrimidine ribonucleotides interconversion, salvage pathways of pyrimidine ribonucleotides
UniProt: O88425
Entrez ID: 54369
|
Does Knockout of Gm7356 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Gm7356
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm7356 (predicted gene 7356)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt:
Entrez ID: 664821
|
Does Knockout of Alg11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Alg11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Alg11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Mus musculus (mouse), Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q3TZM9
Entrez ID: 207958
|
Does Knockout of Shc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Shc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Shc2 (SHC (Src homology 2 domain containing) transforming protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, intracellular signal transduction
Pathways: Alcoholism - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signalling to ERKs, Signalling to RAS, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway
UniProt: Q8BMC3
Entrez ID: 216148
|
Does Knockout of Maf1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Maf1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Maf1 (MAF1 homolog, negative regulator of RNA polymerase III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase I, negative regulation of transcription by RNA polymerase III; MF: GABA receptor binding, RNA polymerase III core binding, RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, RNA polymerase III type 3 promoter sequence-specific DNA binding; CC: axon, cytoplasm, cytosol, dendrite, inhibitory synapse, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Regulation of PTEN gene transcription, Signal Transduction
UniProt: Q9D0U6
Entrez ID: 68877
|
Does Knockout of Llgl2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Llgl2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Llgl2 (LLGL2 scribble cell polarity complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, L-leucine transport, branching involved in labyrinthine layer morphogenesis, cell division, cortical actin cytoskeleton organization, establishment of spindle orientation, establishment or maintenance of polarity of embryonic epithelium, exocytosis, labyrinthine layer blood vessel development, multicellular organism growth, placenta development, post-embryonic development, regulation of Notch signaling pathway, regulation of establishment or maintenance of cell polarity; MF: GTPase activator activity, PDZ domain binding, myosin II binding; CC: cortical actin cytoskeleton, cytoplasm, cytosol, plasma membrane
Pathways: Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q3TJ91
Entrez ID: 217325
|
Does Knockout of Fam118a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Fam118a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fam118a (family with sequence similarity 118, member A)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in membrane. Is expressed in cerebral cortex and cerebral cortex marginal layer. Orthologous to human FAM118A (family with sequence similarity 118 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: identical protein binding, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: Q91YN1
Entrez ID: 73225
|
Does Knockout of Mtif3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Mtif3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mtif3 (mitochondrial translational initiation factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational initiation, ribosome disassembly, translation, translational initiation; MF: ribosomal small subunit binding, ribosome binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q9CZD5
Entrez ID: 76366
|
Does Knockout of Etnppl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Etnppl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Etnppl (ethanolamine phosphate phospholyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cellular response to glucocorticoid stimulus, ceramide phosphoethanolamine catabolic process, lipid homeostasis, phospholipid transfer to membrane, response to food; MF: ethanolamine-phosphate phospho-lyase activity, lyase activity, molecular_function, pyridoxal phosphate binding, transaminase activity; CC: membrane, mitochondrion
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PE
UniProt: Q8BWU8
Entrez ID: 71760
|
Does Knockout of Prdx2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Prdx2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Prdx2 (peroxiredoxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell homeostasis, T cell proliferation, cell redox homeostasis, cellular response to oxidative stress, defense response to tumor cell, hydrogen peroxide catabolic process, hydrogen peroxide metabolic process, leukocyte activation, negative regulation of T cell differentiation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of neuron apoptotic process, positive regulation of MAPK cascade, positive regulation of blood coagulation, regulation of apoptotic process, regulation of hydrogen peroxide metabolic process, removal of superoxide radicals, respiratory burst involved in inflammatory response, response to lipopolysaccharide, response to oxidative stress, thymus development; MF: antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, protein binding, selenium binding, thioredoxin peroxidase activity, thioredoxin-dependent peroxiredoxin activity; CC: cytoplasm, cytosol, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53
UniProt: Q61171
Entrez ID: 21672
|
Does Knockout of S100a16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
S100a16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: S100a16 (S100 calcium binding protein A16)
Type: protein-coding
Summary: Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; gut; heart; nose; and urinary system. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: calcium ion binding, calcium-dependent protein binding, identical protein binding, metal ion binding, protein homodimerization activity; CC: cytoplasm, cytosol, extracellular space, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9D708
Entrez ID: 67860
|
Does Knockout of Sag in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sag
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sag (S-antigen, retina and pineal gland (arrestin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, sensory perception, signal transduction; MF: G protein-coupled receptor binding, opsin binding, phosphoprotein binding, spectrin binding; CC: cell projection, membrane, photoreceptor inner segment, photoreceptor outer segment
Pathways: Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction - Mus musculus (mouse), Sensory Perception, The phototransduction cascade, Visual phototransduction
UniProt: P20443
Entrez ID: 20215
|
Does Knockout of Cdc42se2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Cdc42se2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdc42se2 (CDC42 small effector 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis, regulation of Rho protein signal transduction, regulation of cell shape, regulation of signal transduction; MF: signaling adaptor activity, small GTPase binding; CC: cell projection, cytoplasm, cytoskeleton, membrane, phagocytic cup, plasma membrane
Pathways:
UniProt: Q8BGH7
Entrez ID: 72729
|
Does Knockout of Bysl in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Bysl
|
cell cycle progression
|
breast epithelium
|
Gene: Bysl (bystin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, in utero embryonic development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, stem cell proliferation, trophectodermal cell differentiation; CC: apical part of cell, cell projection, chromosome, cytoplasm, cytoplasmic microtubule, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O54825
Entrez ID: 53414
|
Does Knockout of Chm in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Chm
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Chm (CHM Rab escort protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, small GTPase-mediated signal transduction, vesicle-mediated transport; MF: GDP-dissociation inhibitor activity, GTPase activator activity, enzyme-substrate adaptor activity, protein-containing complex binding, small GTPase binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: A2AD03, Q3UR39, Q9CS14, Q8CBI2
Entrez ID: 12662
|
Does Knockout of Plekha3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Plekha3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Plekha3 (pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, receptor recycling, retrograde transport, endosome to Golgi; MF: identical protein binding, lipid binding, phosphatidylinositol-4-phosphate binding; CC: Golgi apparatus, Golgi membrane, cytosol, early endosome, membrane, recycling endosome, trans-Golgi network
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q9ERS4
Entrez ID: 83435
|
Does Knockout of Edaradd in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Edaradd
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Edaradd (EDAR associated via death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cell differentiation, hair follicle development, odontogenesis of dentin-containing tooth, positive regulation of non-canonical NF-kappaB signal transduction, signal transduction, trachea gland development; MF: death receptor binding, protein binding; CC: cytoplasm
Pathways: NF-kappa B signaling pathway - Mus musculus (mouse)
UniProt: Q5D0F1
Entrez ID: 171211
|
Does Knockout of Usf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Usf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Usf1 (upstream transcription factor 1)
Type: protein-coding
Summary: This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: cellular response to glucose stimulus, cellular response to insulin stimulus, glucose mediated signaling pathway, glucose metabolic process, late viral transcription, lipid homeostasis, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, regulation of transcription from RNA polymerase II promoter by glucose, response to UV, response to hypoxia; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bHLH transcription factor binding, double-stranded DNA binding, enzyme binding, histone deacetylase binding, identical protein binding, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: Golgi apparatus, chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Developmental Biology, ESR-mediated signaling, Estrogen-dependent gene expression, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in pigmentation, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q61069
Entrez ID: 22278
|
Does Knockout of Usp48 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Usp48
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Usp48 (ubiquitin specific peptidase 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cell projection, cilium, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, postsynaptic membrane
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q3V0C5
Entrez ID: 170707
|
Does Knockout of Abi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Abi2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Abi2 (abl interactor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, camera-type eye development, cell migration, cell projection morphogenesis, dendrite development, learning or memory, lens fiber cell morphogenesis, mitophagy, nervous system development, neuron migration, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of lamellipodium assembly, postsynapse organization, postsynaptic actin cytoskeleton organization, regulation of dendritic spine morphogenesis, zonula adherens assembly; MF: identical protein binding, signaling adaptor activity, small GTPase binding, ubiquitin protein ligase binding; CC: SCAR complex, actin filament, actin-based cell projection, adherens junction, anchoring junction, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, filopodium, filopodium tip, glutamatergic synapse, lamellipodium, postsynaptic actin cytoskeleton, synapse
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P62484
Entrez ID: 329165
|
Does Knockout of Kcnh8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Kcnh8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kcnh8 (potassium voltage-gated channel, subfamily H (eag-related), member 8)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Predicted to be involved in negative regulation of apoptotic process; potassium ion transmembrane transport; and regulation of membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of apoptotic process, potassium ion transmembrane transport, potassium ion transport, regulation of membrane potential, transmembrane transport; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, delayed rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P59111
Entrez ID: 211468
|
Does Knockout of Pgrmc2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Pgrmc2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pgrmc2 (progesterone receptor membrane component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembrane system, endoplasmic reticulum, extracellular region, glutamatergic synapse, membrane, nuclear envelope, nucleus, synapse
Pathways: Cellular responses to stimuli, Cellular responses to stress, Heme signaling, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80UU9
Entrez ID: 70804
|
Does Knockout of Cyb5d1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Cyb5d1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cyb5d1 (cytochrome b5 domain containing 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cilium movement and regulation of cilium beat frequency. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and immune system. Orthologous to human CYB5D1 (cytochrome b5 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, cilium movement, regulation of cilium beat frequency; MF: metal ion binding, molecular_function; CC: cell projection, cellular_component, cytoplasm, cytoskeleton
Pathways:
UniProt: Q5NCY3
Entrez ID: 327951
|
Does Knockout of E2f8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
E2f8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: E2f8 (E2F transcription factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle comprising mitosis without cytokinesis, chorionic trophoblast cell differentiation, fibroblast proliferation, hepatocyte differentiation, negative regulation of cytokinesis, negative regulation of transcription by RNA polymerase II, placenta development, positive regulation of DNA endoreduplication, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sprouting angiogenesis, trophoblast giant cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, cytosol, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Transcriptional Regulation by TP53
UniProt: Q58FA4
Entrez ID: 108961
|
Does Knockout of Mettl23 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Mettl23
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mettl23 (methyltransferase like 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, cognition, epigenetic programing of male pronucleus, epigenetic programming in the zygotic pronuclei, epigenetic regulation of gene expression, methylation, positive regulation of transcription by RNA polymerase II, regulation of gene expression; MF: DNA-binding transcription factor binding, heat shock protein binding, histone H3R17 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, protein binding, protein methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, transferase activity; CC: cytoplasm, female pronucleus, male pronucleus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: A2AA28
Entrez ID: 74319
|
Does Knockout of Aldh1a3 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Aldh1a3
|
response to bacteria
|
macrophage
|
Gene: Aldh1a3 (aldehyde dehydrogenase family 1, subfamily A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Harderian gland development, aldehyde metabolic process, embryonic camera-type eye development, embryonic eye morphogenesis, face development, inner ear morphogenesis, lipid metabolic process, locomotory behavior, neuromuscular process controlling balance, nose development, nucleus accumbens development, olfactory pit development, optic cup morphogenesis involved in camera-type eye development, positive regulation of apoptotic process, positive regulation of retinoic acid receptor signaling pathway, protein homotetramerization, retinal metabolic process, retinoic acid biosynthetic process, retinoic acid metabolic process, retinol metabolic process, righting reflex; MF: 3-chloroallyl aldehyde dehydrogenase activity, NAD+ binding, aldehyde dehydrogenase (NAD+) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, protein homodimerization activity, retinal dehydrogenase (NAD+) activity, thyroid hormone binding; CC: cytoplasm
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid
UniProt: Q9JHW9
Entrez ID: 56847
|
Does Knockout of Tas2r104 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Tas2r104
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tas2r104 (taste receptor, type 2, member 104)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M723
Entrez ID: 387340
|
Does Knockout of Pax5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Pax5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pax5 (paired box 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, animal organ morphogenesis, cell differentiation, cerebral cortex development, dopaminergic neuron differentiation, embryonic cranial skeleton morphogenesis, embryonic organ morphogenesis, lateral ventricle development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sensory organ development, skeletal muscle cell differentiation, spermatogenesis, tissue development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in BCR signaling, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q02650
Entrez ID: 18507
|
Does Knockout of Pced1a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Pced1a
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pced1a (PC-esterase domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P1Z5
Entrez ID: 319513
|
Does Knockout of Phf11d in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Phf11d
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Phf11d (PHD finger protein 11D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: A6H5X4
Entrez ID: 219132
|
Does Knockout of Ccnl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Ccnl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ccnl1 (cyclin L1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nuclear speck, nucleoplasm, nucleus, transcription elongation factor complex
Pathways:
UniProt: Q52KE7
Entrez ID: 56706
|
Does Knockout of Prss12 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Prss12
|
response to virus
|
Microglial Cell Line
|
Gene: Prss12 (serine protease 12 neurotrypsin (motopsin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, proteolysis, zymogen activation; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Schaffer collateral - CA1 synapse, axon, cytoplasmic vesicle, dendrite, extracellular region, glutamatergic synapse, membrane, plasma membrane, presynapse, synapse, synaptic cleft, terminal bouton
Pathways:
UniProt: O08762
Entrez ID: 19142
|
Does Knockout of Odc1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Odc1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Odc1 (ornithine decarboxylase, structural 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-amino acid metabolic process, kidney development, polyamine biosynthetic process, polyamine metabolic process, positive regulation of cell population proliferation, putrescine biosynthetic process, putrescine biosynthetic process from arginine, via ornithine, regulation of protein catabolic process, response to virus; MF: carboxy-lyase activity, catalytic activity, lyase activity, ornithine decarboxylase activity, protein homodimerization activity; CC: cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, Regulation of ornithine decarboxylase (ODC), putrescine biosynthesis III, spermine biosynthesis II
UniProt: P00860
Entrez ID: 18263
|
Does Knockout of Igfbp7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Igfbp7
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Igfbp7 (insulin-like growth factor binding protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, inner ear development, regulation of cell growth, regulation of signal transduction, regulation of steroid biosynthetic process; MF: extracellular matrix structural constituent, growth factor binding, insulin-like growth factor binding, receptor ligand activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q61581
Entrez ID: 29817
|
Does Knockout of Ankrd13d in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ankrd13d
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ankrd13d (ankyrin repeat domain 13 family, member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q6PD24
Entrez ID: 68423
|
Does Knockout of Htr2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Htr2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, artery smooth muscle contraction, behavioral response to cocaine, chemical synaptic transmission, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, intracellular calcium ion homeostasis, memory, negative regulation of potassium ion transport, negative regulation of synaptic transmission, glutamatergic, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell population proliferation, positive regulation of cytokine production involved in immune response, positive regulation of cytosolic calcium ion concentration, positive regulation of execution phase of apoptosis, positive regulation of fat cell differentiation, positive regulation of glycolytic process, positive regulation of heat generation, positive regulation of inflammatory response, positive regulation of neuron apoptotic process, positive regulation of phosphatidylinositol biosynthetic process, positive regulation of platelet aggregation, positive regulation of vasoconstriction, presynaptic modulation of chemical synaptic transmission, protein localization to cytoskeleton, regulation of dopamine secretion, release of sequestered calcium ion into cytosol, response to cocaine, response to xenobiotic stimulus, sensitization, sensory perception of temperature stimulus, serotonin receptor signaling pathway, signal transduction, temperature homeostasis, urinary bladder smooth muscle contraction; MF: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gq/11-coupled serotonin receptor activity, identical protein binding, neurotransmitter receptor activity, protein tyrosine kinase activator activity, protein-containing complex binding, serotonin binding, serotonin receptor activity; CC: G protein-coupled serotonin receptor complex, axon, caveola, cell body fiber, cell projection, cytoplasmic vesicle, dendrite, dendritic shaft, glutamatergic synapse, membrane, neurofilament, neuronal cell body, plasma membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR
UniProt: P35363
Entrez ID: 15558
|
Does Knockout of Sgf29 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Sgf29
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sgf29 (SAGA complex associated factor 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of macromolecule metabolic process, regulation of nucleobase-containing compound metabolic process, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, transcription initiation-coupled chromatin remodeling; MF: histone H3K36me3 reader activity, histone H3K4me3 reader activity, methylation-dependent protein binding; CC: ATAC complex, SAGA complex, SAGA-type complex, mitotic spindle, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q9DA08
Entrez ID: 75565
|
Does Knockout of Enpp7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Enpp7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid homeostasis, lipid digestion, lipid metabolic process, negative regulation of DNA replication, negative regulation of cell population proliferation, positive regulation of ceramide biosynthetic process, positive regulation of intestinal cholesterol absorption, positive regulation of sphingomyelin catabolic process, regulation of intestinal lipid absorption, sphingomyelin catabolic process, sphingomyelin metabolic process; MF: hydrolase activity, metal ion binding, phosphoric diester hydrolase activity, sphingomyelin phosphodiesterase activity, zinc ion binding; CC: Golgi apparatus, membrane, microvillus, plasma membrane
Pathways: Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), sphingomyelin metabolism
UniProt: Q3TIW9
Entrez ID: 238011
|
Does Knockout of Gm5142 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gm5142
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm5142 (predicted gene 5142)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5X9
Entrez ID: 380907
|
Does Knockout of Krtap9-1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Krtap9-1
|
response to virus
|
Microglial Cell Line
|
Gene: Krtap9-1 (keratin associated protein 9-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q64526
Entrez ID: 16705
|
Does Knockout of Syt5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Syt5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Syt5 (synaptotagmin V)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, clathrin binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, protein heterodimerization activity, syntaxin binding; CC: axon, cytoplasmic vesicle, dense core granule, endosome, exocytic vesicle, membrane, neuron projection, neuronal cell body, neuronal dense core vesicle membrane, perinuclear region of cytoplasm, plasma membrane, proximal neuron projection, recycling endosome membrane, synapse, synaptic vesicle membrane
Pathways:
UniProt: Q9R0N5
Entrez ID: 53420
|
Does Knockout of Hcls1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Hcls1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Hcls1 (hematopoietic cell specific Lyn substrate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cell migration, cellular response to cytokine stimulus, erythrocyte differentiation, granulocyte colony-stimulating factor signaling pathway, negative regulation of leukocyte apoptotic process, negative regulation of transcription by RNA polymerase II, nuclear transport, positive regulation of cell population proliferation, positive regulation of granulocyte differentiation, positive regulation of macrophage differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein import into nucleus, positive regulation of transcription by RNA polymerase II, regulation of actin filament polymerization, response to hormone; MF: RNA polymerase II-specific DNA-binding transcription factor binding, SH3 domain binding, actin filament binding, protein binding, protein kinase binding, protein-containing complex binding, signaling adaptor activity; CC: actin filament, cortical actin cytoskeleton, cytoplasm, cytosol, mitochondrion, nucleus, plasma membrane, site of polarized growth, transcription regulator complex
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: P49710
Entrez ID: 15163
|
Does Knockout of Klhl6 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Klhl6
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Klhl6 (kelch-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, germinal center formation, proteasome-mediated ubiquitin-dependent protein catabolic process, response to bacterium; CC: Cul3-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q6V595
Entrez ID: 239743
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.