prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Tmem253 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tmem253
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem253 (transmembrane protein 253)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM253 (transmembrane protein 253). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3UNB8
Entrez ID: 619301
|
Does Knockout of Numb in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Numb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Numb (NUMB endocytic adaptor protein)
Type: protein-coding
Summary: This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: adherens junction organization, axonogenesis, forebrain development, lateral ventricle development, negative regulation of protein localization to plasma membrane, nervous system development, neuroblast division in subventricular zone, neuroblast proliferation, positive regulation of cell migration, positive regulation of dendrite morphogenesis, positive regulation of neurogenesis, regulation of neuron differentiation, regulation of postsynapse assembly, regulation of postsynaptic neurotransmitter receptor internalization; MF: alpha-catenin binding, beta-catenin binding, cadherin binding, phospholipid binding, protein binding; CC: apical part of cell, basolateral plasma membrane, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, dendritic spine, early endosome, endosome, endosome membrane, glutamatergic synapse, membrane, nucleus, plasma membrane, postsynaptic density
Pathways: Notch signaling pathway - Mus musculus (mouse)
UniProt: Q9QZS3
Entrez ID: 18222
|
Does Knockout of Tbc1d23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Tbc1d23
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tbc1d23 (TBC1 domain family, member 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, brain development, embryonic brain development, nervous system development, neuron projection development, positive regulation of interleukin-6 production, regulation of inflammatory response, regulation of tumor necrosis factor production, retrograde transport, endosome to Golgi, vesicle tethering to Golgi, vesicle-mediated transport; CC: Golgi apparatus, WASH complex, cytoplasmic vesicle, cytosol, trans-Golgi network
Pathways:
UniProt: Q8K0F1
Entrez ID: 67581
|
Does Knockout of Nrsn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Nrsn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nrsn1 (neurensin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development; CC: cell projection, cytoplasmic vesicle, growth cone, membrane, neuron projection, neuronal cell body, transport vesicle
Pathways:
UniProt: P97799
Entrez ID: 22360
|
Does Knockout of Fign in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Fign
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fign (fidgetin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule severing; MF: ATP binding, ATP hydrolysis activity, microtubule severing ATPase activity, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, microtubule, nuclear matrix, nucleus
Pathways:
UniProt: Q9ERZ6
Entrez ID: 60344
|
Does Knockout of Rmdn2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Rmdn2
|
cell proliferation
|
Regulatory T cell
|
Gene: Rmdn2 (regulator of microtubule dynamics 2)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Located in mitochondrion. Is expressed in adrenal gland; anal canal; glans of male genital tubercle; hindgut; and testis. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: microtubule binding, molecular_function; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, membrane, microtubule, mitochondrion, mitotic spindle, mitotic spindle pole, spindle, spindle microtubule, spindle pole
Pathways:
UniProt: Q8BSE0
Entrez ID: 381110
|
Does Knockout of Cacnb1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Cacnb1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cacnb1 (calcium channel, voltage-dependent, beta 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cellular response to amyloid-beta, chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of muscle contraction, protein targeting to membrane, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; MF: calcium channel activity, calcium channel regulator activity, high voltage-gated calcium channel activity, identical protein binding, phosphoprotein binding, protein binding, protein domain specific binding, protein kinase binding, voltage-gated calcium channel activity; CC: L-type voltage-gated calcium channel complex, T-tubule, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, postsynapse, presynapse, sarcolemma, sarcoplasmic reticulum, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Muscle contraction, Neuronal System, Oxytocin signaling pathway - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Presynaptic depolarization and calcium channel opening, Transmission across Chemical Synapses
UniProt: Q8R3Z5
Entrez ID: 12295
|
Does Knockout of Tas2r114 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Tas2r114
|
cell proliferation
|
Regulatory T cell
|
Gene: Tas2r114 (taste receptor, type 2, member 114)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M722
Entrez ID: 387346
|
Does Knockout of Tonsl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Tonsl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tonsl (tonsoku-like, DNA repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, double-strand break repair via homologous recombination, protein localization to chromatin, replication fork processing; MF: histone binding, histone reader activity; CC: DNA replication factor A complex, FACT complex, MCM complex, chromosome, cytoplasm, nuclear body, nuclear replication fork, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q6NZL6
Entrez ID: 72749
|
Does Knockout of Xpo7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Xpo7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Xpo7 (exportin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, nuclear pore, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9EPK7
Entrez ID: 65246
|
Does Knockout of Lbh in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Lbh
|
cell cycle progression
|
breast epithelium
|
Gene: Lbh (limb-bud and heart)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mammary gland development, mammary gland epithelial cell differentiation, negative regulation of DNA-templated transcription, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of stem cell differentiation, positive regulation of DNA-templated transcription, positive regulation of mammary stem cell proliferation, positive regulation of somatic stem cell division, positive regulation of somatic stem cell population maintenance, regulation of DNA-templated transcription, regulation of MAPK cascade, regulation of gene expression; CC: cytoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9CX60
Entrez ID: 77889
|
Does Knockout of Stat4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Stat4
|
cell cycle progression
|
breast epithelium
|
Gene: Stat4 (signal transducer and activator of transcription 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: T-helper 1 cell differentiation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, defense response, hematopoietic stem cell homeostasis, interleukin-12-mediated signaling pathway, leukocyte proliferation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, response to interleukin-6, response to peptide hormone, signal transduction; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, Hepatitis B - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-2 family signaling, Interleukin-20 family signaling, Interleukin-21 signaling, Interleukin-23 signaling, Interleukin-35 Signalling, JAK-STAT signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: P42228
Entrez ID: 20849
|
Does Knockout of Spag1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Spag1
|
cell cycle progression
|
breast epithelium
|
Gene: Spag1 (sperm associated antigen 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, single fertilization; MF: GTP binding, hydrolase activity, nucleotide binding; CC: cilium, cytoplasm, cytosol, dynein axonemal particle, nucleoplasm, protein folding chaperone complex
Pathways:
UniProt: Q80ZX8
Entrez ID: 26942
|
Does Knockout of Defb48 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Defb48
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Defb48 (defensin beta 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q3UW22
Entrez ID: 432867
|
Does Knockout of Zfp474 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Zfp474
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Zfp474 (zinc finger protein 474)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6V5K9
Entrez ID: 66758
|
Does Knockout of Zfp992 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zfp992
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp992 (zinc finger protein 992)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: B1ASD8
Entrez ID: 433791
|
Does Knockout of Tomm22 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tomm22
|
cell cycle progression
|
breast epithelium
|
Gene: Tomm22 (translocase of outer mitochondrial membrane 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, positive regulation of apoptotic process, protein import into mitochondrial matrix, protein insertion into mitochondrial membrane, protein targeting to mitochondrion, protein transport; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CPQ3
Entrez ID: 223696
|
Does Knockout of Zfp948 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Zfp948
|
cell proliferation
|
Regulatory T cell
|
Gene: Zfp948 (zinc finger protein 948)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q6DFU8
Entrez ID: 381066
|
Does Knockout of Psmg4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Psmg4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psmg4 (proteasome (prosome, macropain) assembly chaperone 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome assembly; MF: molecular_function, protein binding, protein-containing complex binding; CC: cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: P0C7N9
Entrez ID: 69666
|
Does Knockout of Cct4 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Cct4
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Cct4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, cytosol, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80315
Entrez ID: 12464
|
Does Knockout of Slc13a3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Slc13a3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Slc13a3 (solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-ketoglutarate transport, aspartate transmembrane transport, carboxylic acid transport, citrate transport, dicarboxylic acid transport, glutathione transmembrane transport, monoatomic ion transport, sodium ion transmembrane transport, sodium ion transport, succinate transmembrane transport, succinate transport, transmembrane transport; MF: L-aspartate transmembrane transporter activity, alpha-ketoglutarate transmembrane transporter activity, amide transmembrane transporter activity, citrate transmembrane transporter activity, dicarboxylic acid transmembrane transporter activity, glutathione transmembrane transporter activity, high-affinity sodium:dicarboxylate symporter activity, modified amino acid transmembrane transporter activity, organic acid:sodium symporter activity, sodium:dicarboxylate symporter activity, solute:sodium symporter activity, succinate transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q91Y63
Entrez ID: 114644
|
Does Knockout of Trim72 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Trim72
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trim72 (tripartite motif-containing 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, innate immune response, muscle organ development, muscle system process, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of myotube differentiation, plasma membrane repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization, vesicle budding from membrane; MF: identical protein binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, phosphatidylserine binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane, sarcolemma
Pathways:
UniProt: Q1XH17
Entrez ID: 434246
|
Does Knockout of Rad51ap2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Rad51ap2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rad51ap2 (RAD51 associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: protein-containing complex
Pathways:
UniProt: G3UW63
Entrez ID: 209550
|
Does Knockout of Slc41a1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Slc41a1
|
phagocytosis
|
macrophage
|
Gene: Slc41a1 (solute carrier family 41, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to magnesium ion, intracellular magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, metal ion transport, monoatomic cation transport, monoatomic ion transport, sodium ion transmembrane transport; MF: inorganic cation transmembrane transporter activity, magnesium ion transmembrane transporter activity, magnesium:sodium antiporter activity, monoatomic cation transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q8BJA2
Entrez ID: 98396
|
Does Knockout of Myo7b in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Myo7b
|
response to bacteria
|
renal medulla cell line
|
Gene: Myo7b (myosin VIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament-based movement, brush border assembly, cell differentiation, endocytosis, sensory organ development, sensory perception of sound; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: actin cytoskeleton, apical cytoplasm, apical part of cell, brush border, cell projection, cytoplasm, cytoskeleton, membrane, microvillus, myosin complex
Pathways:
UniProt: Q99MZ6
Entrez ID: 17922
|
Does Knockout of Arl2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Arl2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Arl2 (ADP-ribosylation factor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine transport, bicellular tight junction assembly, centrosome cycle, maintenance of protein location in nucleus, negative regulation of GTPase activity, positive regulation of cell-substrate adhesion, positive regulation of microtubule polymerization, protein folding, regulation of aerobic respiration, regulation of glycolytic process, regulation of microtubule polymerization; MF: GDP binding, GTP binding, GTPase activity, nucleotide binding, protein binding; CC: centrosome, ciliary basal body, cytoplasm, cytoskeleton, lateral plasma membrane, microtubule cytoskeleton, mitochondrial intermembrane space, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, RAS processing, SLC-mediated transmembrane transport, Signal Transduction, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9D0J4
Entrez ID: 56327
|
Does Knockout of Cenpm in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Cenpm
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cenpm (centromere protein M)
Type: protein-coding
Summary: This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: biological_process, chromosome segregation; CC: chromosome, chromosome, centromeric region, cytoplasm, inner kinetochore, kinetochore, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CQA0
Entrez ID: 66570
|
Does Knockout of Mpz in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Mpz
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mpz (myelin protein zero)
Type: protein-coding
Summary: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cell aggregation, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction maintenance, myelination, negative regulation of apoptotic process; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: P27573
Entrez ID: 17528
|
Does Knockout of Fabp4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Fabp4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fabp4 (fatty acid binding protein 4, adipocyte)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, cellular response to lithium ion, cellular response to tumor necrosis factor, cholesterol homeostasis, fatty acid metabolic process, fatty acid transport, lipid droplet formation, long-chain fatty acid transport, negative regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of inflammatory response, response to bacterium, white fat cell differentiation; MF: fatty acid binding, hormone receptor binding, lipid binding, long-chain fatty acid binding, long-chain fatty acid transmembrane transporter activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Triglyceride catabolism, Triglyceride metabolism
UniProt: P04117
Entrez ID: 11770
|
Does Knockout of Acy1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Acy1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Acy1 (aminoacylase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid metabolic process, protein catabolic process; MF: aminoacylase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytoplasm, extracellular exosome
Pathways: Aflatoxin activation and detoxification, Arginine biosynthesis - Mus musculus (mouse), Biological oxidations, Drug ADME, Metabolism, Paracetamol ADME
UniProt: Q99JW2
Entrez ID: 109652
|
Does Knockout of Pogz in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pogz
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pogz (pogo transposable element with ZNF domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, double-strand break repair via homologous recombination, kinetochore assembly, mitotic sister chromatid cohesion, positive regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: chromatin, chromosome, ciliary basal body, cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q8BZH4
Entrez ID: 229584
|
Does Knockout of 4930546C10Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
4930546C10Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: 4930546C10Rik (RIKEN cDNA 4930546C10 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 78931
|
Does Knockout of Pon3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Pon3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pon3 (paraoxonase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, coumarin catabolic process, establishment of localization in cell, lactone catabolic process, negative regulation of superoxide anion generation, phenylacetate catabolic process, regulation of cellular response to drug, renal sodium ion transport, response to toxic substance; MF: acyl-L-homoserine-lactone lactonohydrolase activity, aryldialkylphosphatase activity, arylesterase activity, dihydrocoumarin hydrolase activity, hydrolase activity, metal ion binding, protein homodimerization activity; CC: extracellular region, extracellular space
Pathways: Arachidonate metabolism, Atorvastatin ADME, Drug ADME, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids
UniProt: Q62087
Entrez ID: 269823
|
Does Knockout of Hoxb13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Hoxb13
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hoxb13 (homeobox B13)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial cell maturation involved in prostate gland development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; and regulation of growth. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb bud; and tail. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and renal cell carcinoma. Orthologous to human HOXB13 (homeobox B13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, epithelial cell maturation involved in prostate gland development, morphogenesis of an epithelium, negative regulation of transcription by RNA polymerase II, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, prostate gland development, regulation of DNA-templated transcription, regulation of growth, regulation of transcription by RNA polymerase II, response to testosterone; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, methyl-CpG binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: P70321
Entrez ID: 15408
|
Does Knockout of Cyyr1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cyyr1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cyyr1 (cysteine and tyrosine-rich protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8VIH7
Entrez ID: 224405
|
Does Knockout of Chodl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Chodl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chodl (chondrolectin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of axonogenesis, regulation of neuron projection development; MF: carbohydrate binding, hyaluronic acid binding, protein binding; CC: centrosome, cytoplasm, cytosol, membrane, perinuclear region of cytoplasm
Pathways:
UniProt: Q9CXM0
Entrez ID: 246048
|
Does Knockout of Decr2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Decr2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Decr2 (2-4-dienoyl-Coenzyme A reductase 2, peroxisomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, unsaturated fatty acid biosynthetic process; MF: 2,4-dienoyl-CoA reductase (NADPH) activity, GTPase binding, oxidoreductase activity, protein-containing complex binding, trans-2-enoyl-CoA reductase (NADPH) activity; CC: peroxisomal membrane, peroxisome
Pathways: Beta-oxidation of very long chain fatty acids, Fatty acid metabolism, Metabolism, Metabolism of lipids, Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, fatty acid β-oxidation IV (unsaturated, even number)
UniProt: Q9WV68
Entrez ID: 26378
|
Does Knockout of Gbp11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gbp11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gbp11 (guanylate binding protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q2TA93
Entrez ID: 634650
|
Does Knockout of Robo1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Robo1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Robo1 (roundabout guidance receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Roundabout signaling pathway, aorta development, aortic valve morphogenesis, axon guidance, axon midline choice point recognition, cell differentiation, cell migration involved in sprouting angiogenesis, chemorepulsion involved in postnatal olfactory bulb interneuron migration, chemotaxis, coronary vasculature development, endocardial cushion formation, heart development, heart induction, homophilic cell adhesion via plasma membrane adhesion molecules, kidney development, mammary duct terminal end bud growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of chemokine-mediated signaling pathway, negative regulation of gene expression, negative regulation of mammary gland epithelial cell proliferation, negative regulation of negative chemotaxis, negative regulation of synapse assembly, nervous system development, neuron projection extension, olfactory bulb interneuron development, outflow tract septum morphogenesis, positive regulation of MAPK cascade, positive regulation of Notch signaling pathway, positive regulation of Rho protein signal transduction, positive regulation of axonogenesis, positive regulation of gene expression, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular endothelial growth factor signaling pathway, pulmonary valve morphogenesis, regulation of dendrite morphogenesis, ventricular septum development, ventricular septum morphogenesis; MF: LRR domain binding, axon guidance receptor activity, identical protein binding, protein binding; CC: axolemma, axon, cell projection, cell surface, cilium, cytoplasm, cytosol, dendrite, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, neuronal cell body, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Regulation of expression of SLITs and ROBOs, Role of ABL in ROBO-SLIT signaling, SLIT2:ROBO1 increases RHOA activity, Signaling by ROBO receptors
UniProt: O89026
Entrez ID: 19876
|
Does Knockout of Clta in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Clta
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Clta (clathrin light chain A)
Type: protein-coding
Summary: Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, clathrin coat assembly, clathrin-dependent endocytosis, intracellular protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: GTPase binding, clathrin heavy chain binding, peptide binding, protein-containing complex binding, structural molecule activity; CC: Golgi apparatus, clathrin coat, clathrin coat of coated pit, clathrin coat of trans-Golgi network vesicle, clathrin complex, clathrin vesicle coat, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, endosome, glutamatergic synapse, lysosome, membrane, plasma membrane, postsynaptic endocytic zone, presynaptic endocytic zone membrane, spindle, synaptic vesicle membrane
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lysosome - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: B1AWD9, Q6PFA2, B1AWE1, B1AWD8, B1AWE0
Entrez ID: 12757
|
Does Knockout of Ndufs7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ndufs7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ndufs7 (NADH:ubiquinone oxidoreductase core subunit S7)
Type: protein-coding
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity and protease binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; respiratory system; retina; and urinary system. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: aerobic respiration, electron transport coupled proton transport, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis; MF: 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, monooxygenase activity, oxidoreductase activity, protease binding, quinone binding; CC: membrane, mitochondrial inner membrane, mitochondrion, neuronal cell body, respiratory chain complex I, synaptic membrane
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9DC70
Entrez ID: 75406
|
Does Knockout of Mogat1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Mogat1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Mogat1 (monoacylglycerol O-acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol biosynthetic process, glycerol metabolic process, lipid metabolic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycerolipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Triglyceride biosynthesis, Triglyceride metabolism
UniProt: Q91ZV4
Entrez ID: 68393
|
Does Knockout of Tmem86a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tmem86a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem86a (transmembrane protein 86A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: alkenylglycerophosphocholine hydrolase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9D8N3
Entrez ID: 67893
|
Does Knockout of Sgo1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Sgo1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sgo1 (shugoshin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, centriole-centriole cohesion, chromosome segregation, meiotic chromosome segregation, mitotic sister chromatid cohesion, centromeric; MF: kinase binding; CC: centrosome, chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, nuclear speck, nucleoplasm, nucleus, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, EML4 and NUDC in mitotic spindle formation, G2/M Transition, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CXH7
Entrez ID: 72415
|
Does Knockout of Tlr4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Tlr4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tlr4 (toll-like receptor 4)
Type: protein-coding
Summary: This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: B cell proliferation involved in immune response, ERK1 and ERK2 cascade, MyD88-dependent toll-like receptor signaling pathway, NK T cell activation, TRIF-dependent toll-like receptor signaling pathway, activation of NF-kappaB-inducing kinase activity, activation of innate immune response, astrocyte development, bone morphogenesis, canonical NF-kappaB signal transduction, cellular response to amyloid-beta, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to mechanical stimulus, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to type II interferon, defense response to Gram-negative bacterium, defense response to bacterium, detection of lipopolysaccharide, detection of mechanical stimulus involved in sensory perception of pain, detection of stimulus, detection of temperature stimulus involved in sensory perception of pain, gene expression, growth plate cartilage morphogenesis, immune effector process, immune response, immune system process, inflammatory response, innate immune response, innate immune response-activating signaling pathway, intestinal epithelial structure maintenance, leukocyte activation, leukotriene metabolic process, lipopolysaccharide-mediated signaling pathway, macrophage activation, mast cell activation, microglia differentiation, microglial cell activation, negative regulation of ERK1 and ERK2 cascade, negative regulation of cold-induced thermogenesis, negative regulation of cytokine production involved in inflammatory response, negative regulation of interleukin-17 production, negative regulation of interleukin-23 production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, negative regulation of type II interferon production, neurogenesis, nitric oxide production involved in inflammatory response, phagocytosis, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MHC class II biosynthetic process, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cellular response to macrophage colony-stimulating factor stimulus, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of cytokine production involved in inflammatory response, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-1 production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-13 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of lymphocyte proliferation, positive regulation of macrophage activation, positive regulation of macrophage cytokine production, positive regulation of matrix metallopeptidase secretion, positive regulation of nitric oxide biosynthetic process, positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of platelet activation, positive regulation of reactive oxygen species biosynthetic process, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of stress-activated MAPK cascade, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of dendritic cell cytokine production, regulation of inflammatory response, regulation of toll-like receptor 4 signaling pathway, regulation of tumor necrosis factor production, response to bacterium, response to ethanol, response to fatty acid, response to lipopolysaccharide, response to oxidative stress, signal transduction, signal transduction involved in regulation of gene expression, toll-like receptor 4 signaling pathway, toll-like receptor signaling pathway, wound healing involved in inflammatory response; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, identical protein binding, lipopolysaccharide binding, lipopolysaccharide immune receptor activity, phosphatidylinositol 3-kinase binding, protein binding, protein heterodimerization activity, signaling receptor activity, signaling receptor binding, transmembrane signaling receptor activity; CC: cell projection, cell surface, cytoplasm, early endosome, endosome, endosome membrane, external side of plasma membrane, lipopolysaccharide receptor complex, membrane, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, receptor complex, ruffle
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Alcoholic liver disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apoptosis, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Cellular responses to stimuli, Cellular responses to stress, Chagas disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Heme signaling, Hepatitis B - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Malaria - Mus musculus (mouse), Measles - Mus musculus (mouse), MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Programmed Cell Death, Proteoglycans in cancer - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TLR by endogenous ligand, Rheumatoid arthritis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q9QUK6
Entrez ID: 21898
|
Does Knockout of Morf4l1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,536
|
Knockout
|
Morf4l1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Morf4l1 (mortality factor 4 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell population proliferation, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: chromatin binding, protein binding; CC: NuA4 histone acetyltransferase complex, Sin3-type complex, nuclear speck, nucleosome, nucleus
Pathways:
UniProt: P60762
Entrez ID: 21761
|
Does Knockout of Mup16 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Mup16
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mup16 (major urinary protein 16)
Type: protein-coding
Summary: Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology:
Pathways:
UniProt: P02762
Entrez ID: 100039177
|
Does Knockout of Mptx2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Mptx2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mptx2 (mucosal pentraxin 2)
Type: protein-coding
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: acute-phase response, innate immune response; MF: complement component C1q complex binding, metal ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: D3YYJ7
Entrez ID: 100504232
|
Does Knockout of Padi6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Padi6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Padi6 (peptidyl arginine deiminase, type VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasm organization, cytoskeleton organization, embryonic cleavage, epigenetic programming in the zygotic pronuclei, in utero embryonic development, intracellular protein localization, protein storage, regulation of translation by machinery localization; MF: calcium ion binding, identical protein binding, protein binding, protein-arginine deiminase activity, structural constituent of cytoplasmic lattice, tubulin binding; CC: cortical granule, cytoplasm, cytoplasmic lattice, cytoplasmic vesicle, intermediate filament cytoskeleton, nucleus, ooplasm
Pathways: Chromatin modifying enzymes, Chromatin organization, protein citrullination
UniProt: Q8K3V4
Entrez ID: 242726
|
Does Knockout of Hccs in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Hccs
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hccs (holocytochrome c synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heme binding, holocytochrome-c synthase activity, lyase activity, metal ion binding, protein binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Respiratory electron transport
UniProt: P53702
Entrez ID: 15159
|
Does Knockout of Cdh5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Cdh5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Cdh5 (cadherin 5)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adherens junction organization, bicellular tight junction assembly, blood vessel endothelial cell migration, blood vessel maturation, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell migration involved in sprouting angiogenesis, cell morphogenesis, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, endothelial cell morphogenesis, homophilic cell adhesion via plasma membrane adhesion molecules, intracellular calcium ion homeostasis, negative regulation of cell population proliferation, negative regulation of endothelial cell apoptotic process, negative regulation of inflammatory response, negative regulation of microtubule polymerization, positive regulation of BMP signaling pathway, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of establishment of endothelial barrier, positive regulation of gene expression, positive regulation of intracellular signal transduction, positive regulation of protein-containing complex assembly, protein localization to bicellular tight junction, regulation of establishment of cell polarity, regulation of vascular permeability, transforming growth factor beta receptor signaling pathway; MF: BMP receptor binding, beta-catenin binding, cadherin binding, calcium ion binding, cell-cell adhesion mediator activity, fibrinogen binding, metal ion binding, protein binding, protein phosphatase binding, protein tyrosine kinase binding, signaling receptor binding, signaling receptor complex adaptor activity, transmembrane transporter binding, vascular endothelial growth factor receptor 2 binding; CC: adherens junction, anchoring junction, bicellular tight junction, catenin complex, cell junction, cell periphery, cell surface, cell-cell junction, cytoplasm, external side of plasma membrane, membrane, nuclear membrane, nucleoplasm, plasma membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability
UniProt: P55284
Entrez ID: 12562
|
Does Knockout of Lpar3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Lpar3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lpar3 (lysophosphatidic acid receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, bleb assembly, gene expression, positive regulation of MAPK cascade, positive regulation of calcium ion transport, positive regulation of collateral sprouting, signal transduction; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, lysophosphatidic acid receptor activity, phospholipid binding; CC: axon, cilium, cytoplasm, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Lysosphingolipid and LPA receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q9EQ31
Entrez ID: 65086
|
Does Knockout of Hacd1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Hacd1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hacd1 (3-hydroxyacyl-CoA dehydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cementum mineralization, fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, myotube differentiation, positive regulation of cell-substrate adhesion, protein-containing complex assembly, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, sphingolipid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: 3-hydroxyacyl-CoA dehydratase activity, enzyme binding, hydroxyapatite binding, lyase activity, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9QY80
Entrez ID: 30963
|
Does Knockout of Rgs18 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Rgs18
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rgs18 (regulator of G-protein signaling 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction, regulation of G protein-coupled receptor signaling pathway; CC: cytoplasm
Pathways: G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q99PG4
Entrez ID: 64214
|
Does Knockout of Vax1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Vax1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vax1 (ventral anterior homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: astrocyte differentiation, axon guidance, brain development, camera-type eye development, central nervous system development, glial cell differentiation, negative regulation of neuroblast proliferation, negative regulation of transcription by RNA polymerase II, nervous system development, neuroepithelial cell differentiation, neuron differentiation, neuron migration, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, roof of mouth development, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q2NKI2
Entrez ID: 22326
|
Does Knockout of Gsc in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gsc
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gsc (goosecoid homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, animal organ development, dorsal/ventral neural tube patterning, ear development, embryonic skeletal system morphogenesis, forebrain development, middle ear morphogenesis, muscle organ morphogenesis, negative regulation of Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, neural crest cell fate specification, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q02591
Entrez ID: 14836
|
Does Knockout of Zfp583 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Zfp583
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp583 (zinc finger protein 583)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3V080
Entrez ID: 213011
|
Does Knockout of Mzt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Mzt2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mzt2 (mitotic spindle organizing protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin ring complex, nucleoplasm, spindle
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q9CQ25
Entrez ID: 72083
|
Does Knockout of Gm15107 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Gm15107
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Gm15107 (predicted gene 15107)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1B0X0
Entrez ID: 434864
|
Does Knockout of Perp in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Perp
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Perp (PERP, TP53 apoptosis effector)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, amelogenesis, apoptotic process, cell adhesion, cell-cell adhesion, desmosome organization, heterotypic cell-cell adhesion, intrinsic apoptotic signaling pathway by p53 class mediator, mammary gland duct morphogenesis, positive regulation of T cell apoptotic process, positive regulation of neutrophil chemotaxis, positive regulation of proteolysis, tissue homeostasis; CC: Golgi apparatus, anchoring junction, cell-cell junction, cytoplasm, desmosome, membrane, mitochondrion, plasma membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization, p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9JK95
Entrez ID: 64058
|
Does Knockout of Socs4 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Socs4
|
response to bacteria
|
renal medulla cell line
|
Gene: Socs4 (suppressor of cytokine signaling 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, intracellular signal transduction, negative regulation of epidermal growth factor-activated receptor activity, negative regulation of signal transduction, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination
Pathways: Insulin signaling pathway - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse)
UniProt: Q91ZA6
Entrez ID: 67296
|
Does Knockout of Psma3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Psma3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Psma3 (proteasome subunit alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O70435
Entrez ID: 19167
|
Does Knockout of Hlf in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Hlf
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hlf (hepatic leukemia factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhythmic process, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q8BW74
Entrez ID: 217082
|
Does Knockout of Apol11a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Apol11a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Apol11a (apolipoprotein L 11a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chloride transmembrane transport, cytolysis by host of symbiont cells, innate immune response, lipid transport, lipoprotein metabolic process; MF: chloride channel activity, lipid binding, molecular_function; CC: extracellular region, extracellular space, high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Scavenging of heme from plasma, Vesicle-mediated transport
UniProt: E9PZG0
Entrez ID: 626615
|
Does Knockout of Hspg2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Hspg2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hspg2 (perlecan (heparan sulfate proteoglycan 2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, animal organ morphogenesis, brain development, cardiac muscle tissue development, cartilage development involved in endochondral bone morphogenesis, cell differentiation, chondrocyte differentiation, circulatory system development, embryonic skeletal system morphogenesis, endochondral ossification, extracellular matrix organization, intracellular protein localization, negative regulation of amyloid fibril formation, negative regulation of cell adhesion, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, positive regulation of endothelial cell proliferation, receptor-mediated endocytosis, smoothened signaling pathway, tissue development; MF: calcium ion binding, collagen V binding, extracellular matrix structural constituent conferring compression resistance, metal ion binding, protease binding, protein binding; CC: Golgi lumen, basement membrane, extracellular matrix, extracellular region
Pathways: ECM-receptor interaction - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse)
UniProt: Q05793
Entrez ID: 15530
|
Does Knockout of Tlr5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Tlr5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tlr5 (toll-like receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, immune system process, inflammatory response, innate immune response, positive regulation of cytokine production, positive regulation of interleukin-8 production, positive regulation of nitric oxide biosynthetic process, regulation of tumor necrosis factor production, signal transduction, toll-like receptor 5 signaling pathway, toll-like receptor signaling pathway; MF: interleukin-1 receptor binding, pattern recognition receptor activity, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Inflammatory bowel disease - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9JLF7
Entrez ID: 53791
|
Does Knockout of Ccdc152 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ccdc152
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ccdc152 (coiled-coil domain containing 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A2I3BPP3, E9PX14
Entrez ID: 100039139
|
Does Knockout of Nsa2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Nsa2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nsa2 (NSA2 ribosome biogenesis homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleus, preribosome, preribosome, large subunit precursor, ribonucleoprotein complex
Pathways:
UniProt: Q9CR47
Entrez ID: 59050
|
Does Knockout of Gpr137b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gpr137b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpr137b (G protein-coupled receptor 137B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, negative regulation of bone resorption, negative regulation of osteoclast differentiation, positive regulation of TORC1 signaling, positive regulation of protein localization to lysosome, regulation of autophagy, regulation of macrophage activation; CC: lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q8BNQ3
Entrez ID: 83924
|
Does Knockout of Lrrfip1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Lrrfip1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lrrfip1 (leucine rich repeat (in FLII) interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein homodimerization activity; CC: cytoplasm, cytosol, nucleus, plasma membrane
Pathways:
UniProt: Q3UZ39
Entrez ID: 16978
|
Does Knockout of Sclt1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Sclt1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sclt1 (sodium channel and clathrin linker 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, clustering of voltage-gated sodium channels; MF: clathrin binding, sodium channel regulator activity; CC: centriole, centrosome, ciliary basal body, ciliary transition fiber, clathrin complex, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: G5E861
Entrez ID: 67161
|
Does Knockout of Ptms in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Ptms
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ptms (parathymosin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II; MF: histone binding, zinc ion binding
Pathways:
UniProt: Q9D0J8
Entrez ID: 69202
|
Does Knockout of Dvl1 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Dvl1
|
response to bacteria
|
macrophage
|
Gene: Dvl1 (dishevelled segment polarity protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, axon extension, axon guidance, axonogenesis, canonical Wnt signaling pathway, cochlea morphogenesis, collateral sprouting, convergent extension involved in neural plate elongation, convergent extension involved in organogenesis, cytoplasmic microtubule organization, dendrite morphogenesis, dendritic spine morphogenesis, heart looping, intracellular signal transduction, neural tube development, neuromuscular junction development, neurotransmitter secretion, outflow tract morphogenesis, positive regulation of excitatory postsynaptic potential, positive regulation of neuron projection arborization, positive regulation of neuron projection development, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, postsynapse organization, prepulse inhibition, presynapse assembly, protein localization to microtubule, protein localization to nucleus, protein stabilization, receptor clustering, regulation of DNA-templated transcription, regulation of postsynapse organization, regulation of protein localization, regulation of synaptic vesicle exocytosis, skeletal muscle acetylcholine-gated channel clustering, social behavior, synapse organization, synaptic vesicle exocytosis; MF: beta-catenin binding, enzyme binding, frizzled binding, identical protein binding, protein binding, protein kinase binding, small GTPase binding; CC: Schaffer collateral - CA1 synapse, Wnt signalosome, axon, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dendritic spine, glutamatergic synapse, growth cone, lateral plasma membrane, membrane, microtubule, microtubule cytoskeleton, neuron projection, neuronal cell body, neuronal dense core vesicle, plasma membrane, postsynaptic density, presynapse, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Degradation of DVL, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, WNT mediated activation of DVL, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P51141
Entrez ID: 13542
|
Does Knockout of Rbm38 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Rbm38
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rbm38 (RNA binding motif protein 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, signal transduction by p53 class mediator, RNA splicing, cell differentiation, mRNA processing, negative regulation of cell population proliferation, regulation of RNA splicing, regulation of cell cycle, regulation of myotube differentiation; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q62176
Entrez ID: 56190
|
Does Knockout of Shisa7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Shisa7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Shisa7 (shisa family member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamma-aminobutyric acid receptor clustering, gamma-aminobutyric acid signaling pathway, memory, positive regulation of long-term synaptic potentiation, regulation of AMPA glutamate receptor clustering, regulation of AMPA receptor activity, regulation of GABA-A receptor activity; MF: GABA receptor binding, ionotropic glutamate receptor binding, protein binding; CC: AMPA glutamate receptor complex, asymmetric, glutamatergic, excitatory synapse, dendritic spine membrane, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, postsynaptic specialization membrane, synapse
Pathways:
UniProt: Q8C3Q5
Entrez ID: 232813
|
Does Knockout of Zbtb18 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Zbtb18
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zbtb18 (zinc finger and BTB domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum development, cerebral cortex development, hippocampus development, homeostasis of number of cells, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neuron development, positive regulation of transcription by RNA polymerase II, regulation of cell division, regulation of transcription by RNA polymerase II, skeletal muscle tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9WUK6
Entrez ID: 30928
|
Does Knockout of Nusap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,565
|
Knockout
|
Nusap1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nusap1 (nucleolar and spindle associated protein 1)
Type: protein-coding
Summary: Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Located in nucleolus. Is active in mitotic spindle. Is expressed in several structures, including genitourinary system; gut; immune system; respiratory system; and skin. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, establishment of mitotic spindle localization, microtubule cytoskeleton organization, mitotic chromosome condensation, mitotic cytokinesis, mitotic sister chromatid segregation, positive regulation of mitotic nuclear division; MF: DNA binding, microtubule binding; CC: chromosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle, nucleolus, nucleus, spindle
Pathways:
UniProt: Q9ERH4
Entrez ID: 108907
|
Does Knockout of Herc3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Herc3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Herc3 (hect domain and RLD 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: G5E876, A6H6S0, Q8CFQ0, D3Z3U0, A0A0N4SW02, D3Z2S3, D3Z6D4, A0A0N4SVW7
Entrez ID: 73998
|
Does Knockout of Kif13b in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Kif13b
|
response to bacteria
|
renal medulla cell line
|
Gene: Kif13b (kinesin family member 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of protein localization, microtubule-based movement, regulation of axonogenesis, vesicle transport along microtubule; MF: 14-3-3 protein binding, ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, microtubule binding, microtubule motor activity, nucleotide binding, protein kinase binding; CC: axon, cytoplasm, cytoskeleton, cytosol, kinesin complex, microtubule, microvillus, paranode region of axon
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: E9Q4K7, A0A286YCV9, A0A286YD28
Entrez ID: 16554
|
Does Knockout of Cel in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Cel
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cel (carboxyl ester lipase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide catabolic process, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, pancreatic juice secretion, retinol metabolic process; MF: acetylesterase activity, carboxylic ester hydrolase activity, glycosphingolipid binding, hydrolase activity, phosphatidylcholine lysophospholipase activity, protein-containing complex binding, retinyl-palmitate esterase activity, sterol ester esterase activity, triacylglycerol lipase activity; CC: cytoplasm, extracellular region, extracellular space, membrane, protein-containing complex, zymogen granule
Pathways: Digestion, Digestion and absorption, Digestion of dietary lipid, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Steroid biosynthesis - Mus musculus (mouse), triacylglycerol degradation
UniProt: Q64285
Entrez ID: 12613
|
Does Knockout of Hbb-y in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Hbb-y
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hbb-y (hemoglobin Y, beta-like embryonic chain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbon dioxide transport, erythrocyte development, negative regulation of transcription by RNA polymerase II, oxygen transport; MF: heme binding, hemoglobin alpha binding, metal ion binding, oxygen binding, oxygen carrier activity, protein-containing complex binding; CC: haptoglobin-hemoglobin complex, hemoglobin complex
Pathways:
UniProt: P02104
Entrez ID: 15135
|
Does Knockout of Bmx in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Bmx
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Bmx (BMX non-receptor tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, adaptive immune response, apoptotic process, cell adhesion, intracellular signal transduction, signal transduction; MF: ATP binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, plasma membrane, ruffle membrane
Pathways:
UniProt: P97504
Entrez ID: 12169
|
Does Knockout of Spire1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Spire1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Spire1 (spire type actin nucleation factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi vesicle transport, actin cytoskeleton organization, actin filament network formation, actin filament organization, actin nucleation, behavioral fear response, cleavage furrow formation, dendritic spine development, establishment of meiotic spindle localization, formin-nucleated actin cable assembly, intracellular transport, polar body extrusion after meiotic divisions, positive regulation of double-strand break repair, positive regulation of mitochondrial fission, protein transport, vesicle-mediated transport; MF: actin binding, microtubule binding, molecular_function; CC: Golgi apparatus, cell cortex, cleavage furrow, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, membrane, mitochondrial outer membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q52KF3
Entrez ID: 68166
|
Does Knockout of Gnao1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Gnao1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gnao1 (guanine nucleotide binding protein, alpha O)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, locomotory behavior, negative regulation of calcium ion transport, negative regulation of insulin secretion, postsynaptic modulation of chemical synaptic transmission, regulation of heart contraction, response to monoamine, response to serotonin, signal transduction, vesicle docking involved in exocytosis; MF: G protein activity, G protein-coupled serotonin receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activating protein binding, GTPase activity, corticotropin-releasing hormone receptor 1 binding, guanyl nucleotide binding, hydrolase activity, metal ion binding, mu-type opioid receptor binding, nucleotide binding, potassium channel activator activity, protein binding, signaling receptor binding; CC: GABA-ergic synapse, cell body, cytoplasm, dendrite, glutamatergic synapse, heterotrimeric G-protein complex, membrane, myelin sheath, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic membrane, presynaptic membrane, synaptic vesicle membrane
Pathways: Alcoholism - Mus musculus (mouse), Beta-catenin independent WNT signaling, Ca2+ pathway, Chagas disease - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Toxoplasmosis - Mus musculus (mouse)
UniProt: P18872
Entrez ID: 14681
|
Does Knockout of Cnksr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Cnksr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnksr2 (connector enhancer of kinase suppressor of Ras 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, postsynapse organization, postsynaptic specialization organization, regulation of signal transduction; MF: identical protein binding, protein binding, protein kinase binding; CC: cytoplasm, extrinsic component of postsynaptic density membrane, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic membrane
Pathways: MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q80YA9
Entrez ID: 245684
|
Does Knockout of Lat in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Lat
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lat (linker for activation of T cells)
Type: protein-coding
Summary: Predicted to enable molecular condensate scaffold activity; protein kinase binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeostasis. Located in cell-cell junction and immunological synapse. Part of COP9 signalosome. Is expressed in liver and thymus primordium. Used to study IgG4-related disease. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Ras protein signal transduction, T cell receptor signaling pathway, adaptive immune response, calcium-mediated signaling, cell surface receptor protein tyrosine kinase signaling pathway, cellular defense response, gene expression, homeostasis of number of cells, immune response, immune system process, inflammatory response, integrin-mediated signaling pathway, intracellular signal transduction, lymphocyte homeostasis, mast cell degranulation, membrane raft distribution, positive regulation of MAPK cascade, regulation of T cell activation, signal transduction; MF: molecular condensate scaffold activity, protein binding, protein kinase binding, signaling adaptor activity, signaling receptor complex adaptor activity; CC: COP9 signalosome, Golgi apparatus, TCR signalosome, cell-cell junction, immunological synapse, membrane, plasma membrane
Pathways: Adaptive Immune System, DAP12 interactions, DAP12 signaling, FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), GPVI-mediated activation cascade, Generation of second messenger molecules, Hemostasis, Immune System, Innate Immune System, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NF-kappa B signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Signal Transduction, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: O54957
Entrez ID: 16797
|
Does Knockout of Ace2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Ace2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ace2 (angiotensin converting enzyme 2)
Type: protein-coding
Summary: Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiotensin maturation, angiotensin-mediated drinking behavior, ceramide biosynthetic process, entry receptor-mediated virion attachment to host cell, maternal process involved in female pregnancy, negative regulation of ERK1 and ERK2 cascade, negative regulation of smooth muscle cell proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of L-proline import across plasma membrane, positive regulation of amino acid transport, positive regulation of cardiac muscle contraction, positive regulation of gap junction assembly, proteolysis, receptor-mediated virion attachment to host cell, regulation of cardiac conduction, regulation of inflammatory response, regulation of systemic arterial blood pressure by renin-angiotensin, symbiont entry into host cell, tryptophan transport; MF: carboxypeptidase activity, endopeptidase activity, hydrolase activity, identical protein binding, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, peptidyl-dipeptidase activity, protein binding, transporter activator activity, virus receptor activity; CC: apical plasma membrane, brush border membrane, cell projection, cell surface, cilium, cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, Protein digestion and absorption - Mus musculus (mouse), Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q8R0I0
Entrez ID: 70008
|
Does Knockout of Adam34 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Adam34
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adam34 (a disintegrin and metallopeptidase domain 34)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is expressed in seminiferous tubule and testis. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: integrin-mediated signaling pathway, male gonad development, proteolysis; MF: metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: external side of plasma membrane, membrane, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: A2RSG8
Entrez ID: 252866
|
Does Knockout of Scrn3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Scrn3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Scrn3 (secernin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of temperature stimulus involved in sensory perception of pain, proteolysis; MF: cysteine-type exopeptidase activity, dipeptidase activity, molecular_function
Pathways:
UniProt: Q3TMH2
Entrez ID: 74616
|
Does Knockout of Efr3b in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Efr3b
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Efr3b (EFR3 homolog B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphatidylinositol phosphate biosynthetic process, protein localization to plasma membrane, social behavior, transmission of nerve impulse; CC: actin cytoskeleton, cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q6ZQ18
Entrez ID: 668212
|
Does Knockout of Krt20 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Krt20
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Krt20 (keratin 20)
Type: protein-coding
Summary: This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: apoptotic process, cellular response to starvation, epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium, regulation of protein secretion; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoplasm, cytoskeleton, cytosol, intermediate filament, intermediate filament cytoskeleton, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q9D312
Entrez ID: 66809
|
Does Knockout of Pdyn in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Pdyn
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pdyn (prodynorphin)
Type: protein-coding
Summary: This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to function as the body's natural way to control addiction. These peptides have been associated with depression, stress, anxiety, response to pain, and maintenance of homeostasis via circadian rhythms and control of appetite. Mutations in the related human gene have been linked to the neurodegenerative disease spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: chemical synaptic transmission, neuropeptide signaling pathway, sensory perception; MF: neuropeptide hormone activity, opioid peptide activity, opioid receptor binding; CC: Golgi apparatus, axon terminus, dendrite, dendritic spine, dense core granule, extracellular region, extracellular space, hippocampal mossy fiber to CA3 synapse, neuronal cell body, neuronal dense core vesicle, neuronal dense core vesicle lumen, plasma membrane, synaptic vesicle
Pathways: Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q3UZW2, O35852, A2ANF0
Entrez ID: 18610
|
Does Knockout of Abo in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Abo
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abo (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, oligosaccharide biosynthetic process, protein glycosylation; MF: alpha-1,3-galactosyltransferase activity, antigen binding, fucosylgalactoside 3-alpha-galactosyltransferase activity, glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, manganese ion binding, metal ion binding, nucleotide binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, extracellular region, membrane, vesicle
Pathways: ABO blood group biosynthesis, Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: P38649
Entrez ID: 80908
|
Does Knockout of L2hgdh in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
L2hgdh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: L2hgdh (L-2-hydroxyglutarate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: small molecule metabolic process; MF: 2-hydroxyglutarate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Butanoate metabolism - Mus musculus (mouse), Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, Metabolism
UniProt: Q91YP0
Entrez ID: 217666
|
Does Knockout of Mlst8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mlst8
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mlst8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, TORC2 signaling, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cytoskeleton organization, negative regulation of apoptotic process, negative regulation of autophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of pentose-phosphate shunt, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization; MF: protein serine/threonine kinase activator activity, protein-macromolecule adaptor activity; CC: TORC1 complex, TORC2 complex, cytoplasm, lysosomal membrane, lysosome, membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, Amino acids regulate mTORC1, Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Cellular response to heat stress, Cellular response to starvation, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Co-stimulation by CD28, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, HSF1-dependent transactivation, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9DCJ1
Entrez ID: 56716
|
Does Knockout of Comtd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,284
|
Knockout
|
Comtd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Comtd1 (catechol-O-methyltransferase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: O-methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, transferase activity; CC: membrane, mitochondrion
Pathways: dopamine degradation
UniProt: Q8BIG7
Entrez ID: 69156
|
Does Knockout of Ubr2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Ubr2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ubr2 (ubiquitin protein ligase E3 component n-recognin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, cellular response to L-leucine, heterochromatin formation, male meiosis I, male meiotic nuclear division, negative regulation of TOR signaling, positive regulation of T cell receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein catabolic process, protein ubiquitination, reciprocal meiotic recombination, spermatogenesis, transposable element silencing, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: L-leucine binding, histone H2A ubiquitin ligase activity, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: chromatin, chromosome, cytoplasm, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q6WKZ8
Entrez ID: 224826
|
Does Knockout of Gcsam in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Gcsam
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gcsam (germinal center associated, signaling and motility)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of lymphocyte migration, regulation of B cell receptor signaling pathway, regulation of lymphocyte migration; MF: actin binding, myosin II binding, protein kinase binding; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q6RFH4
Entrez ID: 14525
|
Does Knockout of Sult1c1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,276
|
Knockout
|
Sult1c1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sult1c1 (sulfotransferase family, cytosolic, 1C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, sulfation, sulfur compound metabolic process, xenobiotic metabolic process; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, alcohol sulfotransferase activity, aryl sulfotransferase activity, bile-salt sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q80VR3
Entrez ID: 20888
|
Does Knockout of Chrna5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Chrna5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Chrna5 (cholinergic receptor, nicotinic, alpha polypeptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral response to nicotine, cellular response to nicotine, detection of mechanical stimulus involved in sensory perception of pain, excitatory postsynaptic potential, membrane depolarization, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular synaptic transmission, presynaptic modulation of chemical synaptic transmission, regulation of neuronal action potential, regulation of postsynaptic membrane potential, response to nicotine, synaptic transmission, cholinergic; MF: acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein-containing complex binding, transmembrane signaling receptor activity; CC: acetylcholine-gated channel complex, cation channel complex, cholinergic synapse, dendrite, dopaminergic synapse, membrane, neuron projection, neuronal cell body, neurotransmitter receptor complex, plasma membrane, postsynaptic membrane, presynapse, synapse, synaptic membrane
Pathways: Acetylcholine binding and downstream events, Highly calcium permeable nicotinic acetylcholine receptors, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Postsynaptic nicotinic acetylcholine receptors, Presynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: Q2MKA5
Entrez ID: 110835
|
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