prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Usp19 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Usp19
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Usp19 (ubiquitin specific peptidase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, negative regulation of proteasomal protein catabolic process, negative regulation of skeletal muscle tissue development, positive regulation of cell cycle process, protein K48-linked deubiquitination, protein deubiquitination, protein stabilization, proteolysis, regulation of ERAD pathway, regulation of cellular response to hypoxia, regulation of protein stability, response to endoplasmic reticulum stress; MF: Hsp90 protein binding, K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q3UJD6
Entrez ID: 71472
|
Does Knockout of Chek2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Chek2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Chek2 (checkpoint kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, autophagosome assembly, cell division, cellular response to bisphenol A, cellular response to gamma radiation, cellular response to stress, cellular response to xenobiotic stimulus, double-strand break repair, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, mitotic DNA damage checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, mitotic spindle assembly, negative regulation of DNA damage checkpoint, positive regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of autophagosome assembly, protein K63-linked ubiquitination, protein autophosphorylation, protein catabolic process, protein stabilization, regulation of DNA-templated transcription, regulation of autophagosome assembly, regulation of protein catabolic process, response to gamma radiation, response to glycoside, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, thymocyte apoptotic process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: Golgi apparatus, PML body, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Stabilization of p53, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z265
Entrez ID: 50883
|
Does Knockout of Glud1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Glud1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Glud1 (glutamate dehydrogenase 1)
Type: protein-coding
Summary: Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-glutamate catabolic process, amino acid metabolic process, glutamine metabolic process, positive regulation of insulin secretion, response to aluminum ion, tricarboxylic acid metabolic process; MF: ADP binding, ATP binding, GTP binding, L-leucine binding, NAD+ binding, enzyme binding, glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase (NADP+) activity, glutamate dehydrogenase [NAD(P)+] activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, protein binding, protein homodimerization activity; CC: cytoplasm, endoplasmic reticulum, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Glutamate and glutamine metabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Necroptosis - Mus musculus (mouse), Nitrogen metabolism - Mus musculus (mouse), Organelle biogenesis and maintenance, Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, arginine biosynthesis IV, glutamate biosynthesis II, glutamate degradation X, glutamine biosynthesis II, glutamine degradation I, proline biosynthesis II
UniProt: P26443
Entrez ID: 14661
|
Does Knockout of Arg2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Arg2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Arg2 (arginase type II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, arginine metabolic process, immune system process, innate immune response, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process, negative regulation of chemokine (C-C motif) ligand 4 production, negative regulation of chemokine (C-C motif) ligand 5 production, negative regulation of defense response to bacterium, negative regulation of interleukin-13 production, negative regulation of interleukin-17 production, negative regulation of macrophage inflammatory protein 1 alpha production, negative regulation of multicellular organismal process, negative regulation of striated muscle contraction, negative regulation of tumor necrosis factor production, negative regulation of type 2 immune response, positive regulation of cellular senescence, regulation of L-arginine import across plasma membrane, regulation of interleukin-1 beta production, regulation of reactive oxygen species biosynthetic process, striated muscle contraction, urea cycle, ureteric bud development; MF: arginase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines, manganese ion binding, metal ion binding, nitric-oxide synthase binding; CC: cytoplasm, mitochondrion
Pathways: Amoebiasis - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, Urea cycle, arginine degradation I (arginase pathway), arginine degradation VI (arginase 2 pathway), citrulline biosynthesis, superpathway of citrulline metabolism, urea cycle
UniProt: O08691
Entrez ID: 11847
|
Does Knockout of Cd81 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Cd81
|
response to bacteria
|
renal medulla cell line
|
Gene: Cd81 (CD81 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell costimulation, adaptive immune response, cellular response to low-density lipoprotein particle stimulus, humoral immune response mediated by circulating immunoglobulin, immune system process, immunological synapse formation, macrophage fusion, myoblast fusion involved in skeletal muscle regeneration, osteoclast fusion, positive regulation of B cell activation, positive regulation of B cell proliferation, positive regulation of B cell receptor signaling pathway, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of MAPK cascade, positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of T cell receptor signaling pathway, positive regulation of T-helper 2 cell cytokine production, positive regulation of adaptive immune memory response, positive regulation of inflammatory response to antigenic stimulus, positive regulation of protein catabolic process in the vacuole, positive regulation of protein exit from endoplasmic reticulum, positive regulation of receptor clustering, positive regulation of transcription by RNA polymerase II, protein localization to lysosome, protein localization to plasma membrane, receptor internalization, regulation of cell motility, regulation of cell population proliferation, regulation of macrophage migration, regulation of protein stability, symbiont entry into host cell; MF: MHC class II protein binding, cholesterol binding, integrin binding, lipid binding, protein binding, transferrin receptor binding, virus receptor activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cytosol, extracellular exosome, immunological synapse, membrane, plasma membrane, tetraspanin-enriched microdomain, vesicle
Pathways: Adaptive Immune System, B cell receptor signaling pathway - Mus musculus (mouse), Complement cascade, Hepatitis C - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Malaria - Mus musculus (mouse), Regulation of Complement cascade
UniProt: P35762
Entrez ID: 12520
|
Does Knockout of Jup in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Jup
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Jup (junction plakoglobin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bundle of His cell-Purkinje myocyte adhesion involved in cell communication, canonical Wnt signaling pathway, cell adhesion, cell migration, cell-cell adhesion, cell-cell junction organization, cellular response to indole-3-methanol, desmosome assembly, detection of mechanical stimulus, negative regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis, positive regulation of cell-matrix adhesion, positive regulation of protein import into nucleus, positive regulation of transcription by RNA polymerase II, protein localization to plasma membrane, regulation of cell population proliferation, regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell action potential, skin development; MF: alpha-catenin binding, cadherin binding, cell adhesion molecule binding, cytoskeletal protein-membrane anchor activity, nuclear receptor binding, protein binding, protein kinase binding, protein phosphatase binding, protein tyrosine kinase binding, protein-containing complex binding, transcription coactivator activity; CC: Z disc, actin cytoskeleton, adherens junction, anchoring junction, apicolateral plasma membrane, catenin complex, cell-cell junction, cornified envelope, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, desmosome, fascia adherens, gamma-catenin-TCF7L2 complex, intercalated disc, intermediate filament, lateral plasma membrane, membrane, nucleus, plasma membrane, protein-DNA complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adherens junctions interactions, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Degradation of CDH1, Developmental Biology, Formation of the cornified envelope, Gastric cancer - Mus musculus (mouse), Immune System, Innate Immune System, Keratinization, Neutrophil degranulation, Pathways in cancer - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of CDH11 Expression and Function, Regulation of CDH11 function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Transcriptional misregulation in cancer - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability
UniProt: Q02257
Entrez ID: 16480
|
Does Knockout of Gjd3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Gjd3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gjd3 (gap junction protein, delta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AV node cell to bundle of His cell communication by electrical coupling, cell communication, cell-cell signaling, gap junction assembly, monoatomic ion transmembrane transport, negative regulation of cardiac conduction, negative regulation of cell communication by electrical coupling involved in cardiac conduction, negative regulation of heart rate, response to glucose, transmembrane transport; MF: gap junction channel activity, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, monoatomic ion channel activity; CC: anchoring junction, cell surface, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q91YD1
Entrez ID: 353155
|
Does Knockout of Cd209c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Cd209c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cd209c (CD209c antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell adhesion, immune response, positive regulation of T cell proliferation, positive regulation of viral life cycle, symbiont entry into host cell; MF: D-mannose binding, carbohydrate binding, metal ion binding, pattern recognition receptor activity, virus receptor activity; CC: external side of plasma membrane, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q91ZW9
Entrez ID: 170776
|
Does Knockout of Ddx49 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,412
|
Knockout
|
Ddx49
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Ddx49 (DEAD box helicase 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4FZF3
Entrez ID: 234374
|
Does Knockout of Haus2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Haus2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Haus2 (HAUS augmin-like complex, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule nucleation, microtubule organizing center organization, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9CQS9
Entrez ID: 66296
|
Does Knockout of Ang in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Ang
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ang (angiogenin, ribonuclease, RNase A family, 5)
Type: protein-coding
Summary: This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: actin filament polymerization, angiogenesis, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cell differentiation, cell migration, cellular response to osmotic stress, cellular response to stress, central nervous system development, cytoplasmic translation, defense response to Gram-positive bacterium, hematopoietic stem cell proliferation, innate immune response, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of smooth muscle cell proliferation, negative regulation of translation, negative regulation of translation in response to stress, positive regulation of endothelial cell proliferation, positive regulation of phosphorylation, positive regulation of protein secretion, rRNA transcription, receptor-mediated endocytosis, response to hormone, response to hypoxia, response to yeast, signal transduction, signaling, stress granule assembly, tRNA destabilization, tRNA stabilization; MF: DNA binding, RNA binding, RNA nuclease activity, actin binding, copper ion binding, endonuclease activity, heparin binding, hydrolase activity, nuclease activity, nucleic acid binding, peptide binding, protein homodimerization activity, receptor ligand activity, ribosome binding, signaling receptor binding, tRNA-specific ribonuclease activity; CC: actin cytoskeleton, angiogenin-PRI complex, basement membrane, chromosome, cytoplasm, cytoplasmic stress granule, endocytic vesicle, extracellular region, extracellular space, growth cone, neuronal cell body, nucleolus, nucleus
Pathways: Adherens junctions interactions, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization
UniProt: P21570
Entrez ID: 11727
|
Does Knockout of Slc24a5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Slc24a5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc24a5 (solute carrier family 24, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion import, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of melanin biosynthetic process, potassium ion transmembrane transport, potassium ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, calcium channel activity, calcium ion transmembrane transporter activity, calcium, potassium:sodium antiporter activity, symporter activity; CC: Golgi apparatus, melanosome, membrane, trans-Golgi network
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules
UniProt: Q8C261
Entrez ID: 317750
|
Does Knockout of Zfp51 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Zfp51
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp51 (zinc finger protein 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q3UZS6, Q3U4L8
Entrez ID: 22709
|
Does Knockout of Atp6v0a4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Atp6v0a4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atp6v0a4 (ATPase, H+ transporting, lysosomal V0 subunit A4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, ossification, proton transmembrane transport, regulation of pH, renal tubular secretion, sensory perception of sound, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATPase binding, P-type proton-exporting transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: apical part of cell, apical plasma membrane, basolateral plasma membrane, brush border, brush border membrane, endosome, membrane, plasma membrane, proton-transporting V-type ATPase, V0 domain, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: Q920R6
Entrez ID: 140494
|
Does Knockout of Pigk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Pigk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pigk (phosphatidylinositol glycan anchor biosynthesis, class K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein, proteolysis; MF: GPI-anchor transamidase activity, metal ion binding, peptidase activity, transferase activity; CC: GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9CXY9
Entrez ID: 329777
|
Does Knockout of Tdrkh in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Tdrkh
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tdrkh (tudor and KH domain containing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, fertilization, male meiotic nuclear division, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: P granule, cytoplasm, cytosol, mitochondrion, pi-body, piP-body
Pathways:
UniProt: Q80VL1
Entrez ID: 72634
|
Does Knockout of Zfp668 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Zfp668
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfp668 (zinc finger protein 668)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: Q8K2R5
Entrez ID: 244219
|
Does Knockout of Tmem79 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tmem79
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmem79 (transmembrane protein 79)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Acts upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Located in lysosomal membrane and trans-Golgi network membrane. Is expressed in alimentary system; genitourinary system; naris; skin; and thymus. Used to study atopic dermatitis. Orthologous to human TMEM79 (transmembrane protein 79). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cornification, cuticle development, epithelial cell maturation, establishment of skin barrier, hair follicle morphogenesis, positive regulation of epidermis development, regulated exocytosis; MF: identical protein binding; CC: Golgi apparatus, cytoplasm, lysosomal membrane, lysosome, membrane, trans-Golgi network membrane
Pathways:
UniProt: Q9D709
Entrez ID: 71913
|
Does Knockout of Stap2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Stap2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Stap2 (signal transducing adaptor family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, signaling adaptor activity; CC: cytoplasm, membrane, plasma membrane
Pathways: PTK6 Activates STAT3, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6
UniProt: Q8R0L1
Entrez ID: 106766
|
Does Knockout of Stn1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Stn1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Stn1 (STN1, CST complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, regulation of DNA metabolic process, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening; MF: DNA binding, protein binding, single-stranded DNA binding, single-stranded telomeric DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, fibrillar center, intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q8K2X3
Entrez ID: 108689
|
Does Knockout of Trim15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Trim15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trim15 (tripartite motif-containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, innate immune response, negative regulation of intracellular transport of viral material, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production, protein K63-linked ubiquitination, suppression of viral release by host; MF: metal ion binding, molecular sequestering activity, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: G3UY57, Q8R096, G3UXC8
Entrez ID: 69097
|
Does Knockout of Pde6h in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Pde6h
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pde6h (phosphodiesterase 6H, cGMP-specific, cone, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of epidermal growth factor receptor signaling pathway, visual perception; MF: 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, hydrolase activity
Pathways: Purine metabolism - Mus musculus (mouse)
UniProt: P61249
Entrez ID: 78600
|
Does Knockout of Clip4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Clip4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Clip4 (CAP-GLY domain containing linker protein family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell cortex, microtubule plus-end, nucleus
Pathways:
UniProt: Q8CI96
Entrez ID: 78785
|
Does Knockout of Oasl2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Oasl2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Oasl2 (2'-5' oligoadenylate synthetase-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, defense response to virus, immune system process, innate immune response, interleukin-27-mediated signaling pathway, negative regulation of viral genome replication, purine nucleotide biosynthetic process, response to virus, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, ATP binding, RNA binding, double-stranded RNA binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: cytosol, membrane, nucleoplasm
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: Q9Z2F2
Entrez ID: 23962
|
Does Knockout of Rps6ka4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Rps6ka4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, positive regulation of transcription by RNA polymerase II, post-translational protein modification, protein phosphorylation, regulation of DNA-templated transcription; MF: ATP binding, histone H3S10 kinase activity, histone H3S28 kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, synapse
Pathways: MAPK signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q9Z2B9
Entrez ID: 56613
|
Does Knockout of Fam221b in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Fam221b
|
cell proliferation
|
Regulatory T cell
|
Gene: Fam221b (family with sequence similarity 221, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C627
Entrez ID: 242408
|
Does Knockout of Dppa5a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Dppa5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dppa5a (developmental pluripotency associated 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of gene expression; MF: RNA binding, mRNA binding; CC: cytoplasm
Pathways:
UniProt: Q9CQS7
Entrez ID: 434423
|
Does Knockout of Snrnp70 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,663
|
Knockout
|
Snrnp70
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1))
Type: protein-coding
Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q62376
Entrez ID: 20637
|
Does Knockout of Zfp809 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Zfp809
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfp809 (zinc finger protein 809)
Type: protein-coding
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within innate immune response and negative regulation of single stranded viral RNA replication via double stranded DNA intermediate. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: innate immune response, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: G3X9G7
Entrez ID: 235047
|
Does Knockout of Apcs in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Apcs
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Apcs (amyloid P component, serum)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, host-mediated suppression of symbiont invasion, innate immune response, negative regulation by host of viral glycoprotein metabolic process, negative regulation of glycoprotein metabolic process, negative regulation of monocyte differentiation, negative regulation of viral process, protein-containing complex assembly; MF: calcium ion binding, carbohydrate binding, complement component C1q complex binding, identical protein binding, metal ion binding, virion binding; CC: extracellular region, extracellular space, protein-containing complex
Pathways:
UniProt: P12246
Entrez ID: 20219
|
Does Knockout of 1700018F24Rik in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
1700018F24Rik
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: 1700018F24Rik (RIKEN cDNA 1700018F24 gene)
Type: protein-coding
Summary: RIKEN cDNA 1700018F24 gene
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: B2RW27
Entrez ID: 69396
|
Does Knockout of Rtcb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Rtcb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, in utero embryonic development, placenta development, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: GTP binding, RNA ligase (GTP) activity, ligase activity, ligase activity, forming phosphoric ester bonds, metal ion binding, nucleotide binding, vinculin binding; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, nuclear envelope, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q99LF4
Entrez ID: 28088
|
Does Knockout of Def6 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Def6
|
cell cycle progression
|
breast epithelium
|
Gene: Def6 (differentially expressed in FDCP 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: vesicle-mediated transport to the plasma membrane; CC: cell projection, cell-cell junction, cytoplasm, cytoskeleton, cytosol, filopodium, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C2K1
Entrez ID: 23853
|
Does Knockout of Marveld2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Marveld2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Marveld2 (MARVEL (membrane-associating) domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, cell-cell junction organization, establishment of endothelial barrier, sensory perception of sound; CC: Schmidt-Lanterman incisure, anchoring junction, apical plasma membrane, basolateral plasma membrane, bicellular tight junction, cell junction, cytoplasm, cytoplasmic vesicle, membrane, paranodal junction, plasma membrane, tight junction, tricellular tight junction
Pathways: Tight junction - Mus musculus (mouse)
UniProt: Q3UZP0
Entrez ID: 218518
|
Does Knockout of Nhej1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Nhej1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nhej1 (non-homologous end joining factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA repair, T cell differentiation, double-strand break repair, double-strand break repair via nonhomologous end joining, immunoglobulin V(D)J recombination, response to ionizing radiation, telomere maintenance; MF: DNA binding, DNA end binding, DNA polymerase binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromosome, fibrillar center, nonhomologous end joining complex, nucleoplasm, nucleus, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q3KNJ2
Entrez ID: 75570
|
Does Knockout of Fkbpl in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Fkbpl
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fkbpl (FK506 binding protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of angiogenesis, regulation of blood vessel branching; CC: extracellular region
Pathways: Cell Cycle, Cell Cycle, Mitotic, G2/M Transition, Mitotic G2-G2/M phases, The role of GTSE1 in G2/M progression after G2 checkpoint
UniProt: O35450
Entrez ID: 56299
|
Does Knockout of Mycbp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Mycbp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mycbp (MYC binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9EQS3
Entrez ID: 56309
|
Does Knockout of Hectd2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Hectd2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hectd2 (HECT domain E3 ubiquitin protein ligase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8CDU6
Entrez ID: 226098
|
Does Knockout of Mettl3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,277
|
Knockout
|
Mettl3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mettl3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, RNA methylation, cell differentiation, cellular response to UV, circadian rhythm, dosage compensation by inactivation of X chromosome, endothelial to hematopoietic transition, forebrain radial glial cell differentiation, gliogenesis, immune system process, innate immune response, mRNA catabolic process, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, methylation, negative regulation of Notch signaling pathway, negative regulation of type I interferon-mediated signaling pathway, oogenesis, positive regulation of cap-independent translational initiation, positive regulation of mRNA catabolic process, positive regulation of translation, primary miRNA processing, regulation of T cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of meiotic cell cycle, rhythmic process, spermatogenesis, stem cell population maintenance; MF: RNA binding, RNA methyltransferase activity, S-adenosyl-L-methionine binding, mRNA binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: Golgi apparatus, RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA
UniProt: Q8C3P7
Entrez ID: 56335
|
Does Knockout of Cfl2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Cfl2
|
phagocytosis
|
macrophage
|
Gene: Cfl2 (cofilin 2, muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament depolymerization, actin filament fragmentation, actin filament organization, actin filament severing, muscle cell cellular homeostasis, positive regulation of actin filament depolymerization, sarcomere organization, skeletal muscle tissue development; MF: actin binding, actin filament binding; CC: I band, Z disc, actin cytoskeleton, cytoplasm, cytoskeleton, nuclear matrix, nucleus
Pathways: Axon guidance - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: P45591
Entrez ID: 12632
|
Does Knockout of Elf2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,570
|
Knockout
|
Elf2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Elf2 (E74-like factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in BCR signaling, Transcriptional regulation by RUNX1
UniProt: Q9JHC9
Entrez ID: 69257
|
Does Knockout of Zfp597 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zfp597
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zfp597 (zinc finger protein 597)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: E9Q6S0
Entrez ID: 71063
|
Does Knockout of Cds1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Cds1
|
response to virus
|
Microglial Cell Line
|
Gene: Cds1 (CDP-diacylglycerol synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, lipid droplet formation, lipid metabolic process, phosphatidylinositol biosynthetic process, phospholipid biosynthetic process, positive regulation of fat cell differentiation; MF: nucleotidyltransferase activity, phosphatidate cytidylyltransferase activity, transferase activity, transferase activity, transferring phosphorus-containing groups; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PI, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I
UniProt: P98191
Entrez ID: 74596
|
Does Knockout of Btbd18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Btbd18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Btbd18 (BTB domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, piRNA transcription, positive regulation of transcription elongation by RNA polymerase II, spermatogenesis, transposable element silencing; CC: nucleus
Pathways:
UniProt: A0A0A6YY25
Entrez ID: 100270744
|
Does Knockout of Tomm22 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Tomm22
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tomm22 (translocase of outer mitochondrial membrane 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, positive regulation of apoptotic process, protein import into mitochondrial matrix, protein insertion into mitochondrial membrane, protein targeting to mitochondrion, protein transport; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CPQ3
Entrez ID: 223696
|
Does Knockout of Tlx1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tlx1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tlx1 (T cell leukemia, homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, animal organ formation, cell fate commitment, central nervous system development, lymph node development, neuron differentiation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spleen development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding; CC: nucleus
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: G3UXB9, Q9QX99
Entrez ID: 21908
|
Does Knockout of Slc9a5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Slc9a5
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc9a5 (solute carrier family 9 (sodium/hydrogen exchanger), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, proton transmembrane transport, regulation of intracellular pH, regulation of pH, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, arrestin family protein binding, potassium:proton antiporter activity, sodium:proton antiporter activity; CC: anchoring junction, cell projection, dendritic spine membrane, endosome, focal adhesion, membrane, neuron spine, plasma membrane, postsynaptic membrane, recycling endosome membrane, synapse, synaptic membrane
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Sodium/Proton exchangers, Transport of small molecules
UniProt: B2RXE2
Entrez ID: 277973
|
Does Knockout of Hyal6 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Hyal6
|
cell proliferation
|
Regulatory T cell
|
Gene: Hyal6 (hyaluronoglucosaminidase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, hyaluronan catabolic process; MF: hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, molecular_function; CC: cytoplasmic vesicle, extracellular region, membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Lysosome - Mus musculus (mouse)
UniProt: Q9D4E9
Entrez ID: 74409
|
Does Knockout of Pycard in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Pycard
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pycard (PYD and CARD domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLRP3 inflammasome complex assembly, activation of innate immune response, apoptotic process, apoptotic signaling pathway, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, defense response to virus, immune system process, inflammatory response, innate immune response, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, macropinocytosis, myeloid dendritic cell activation, myeloid dendritic cell activation involved in immune response, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine production involved in inflammatory response, negative regulation of interferon-beta production, osmosensory signaling pathway, pattern recognition receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of T cell activation, positive regulation of T cell migration, positive regulation of actin filament polymerization, positive regulation of activated T cell proliferation, positive regulation of adaptive immune response, positive regulation of antigen processing and presentation of peptide antigen via MHC class II, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine production, positive regulation of defense response to virus by host, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of phagocytosis, positive regulation of release of cytochrome c from mitochondria, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, protein homooligomerization, pyroptotic inflammatory response, regulation of GTPase activity, regulation of apoptotic process, regulation of autophagy, regulation of inflammatory response, regulation of intrinsic apoptotic signaling pathway, regulation of protein stability, regulation of tumor necrosis factor-mediated signaling pathway, response to bacterium, tumor necrosis factor-mediated signaling pathway; MF: BMP receptor binding, Pyrin domain binding, cysteine-type endopeptidase activator activity, enzyme binding, identical protein binding, interleukin-6 receptor binding, myosin I binding, pattern recognition receptor activity, peptidase activator activity involved in apoptotic process, protease binding, protein binding, protein dimerization activity, protein homodimerization activity, transmembrane transporter binding, tropomyosin binding; CC: AIM2 inflammasome complex, Golgi membrane, IkappaB kinase complex, NLRP1 inflammasome complex, NLRP3 inflammasome complex, NLRP6 inflammasome complex, canonical inflammasome complex, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, microtubule, mitochondrion, neuronal cell body, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, CLEC7A/inflammasome pathway, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Immune System, Inflammasomes, Influenza A - Mus musculus (mouse), Innate Immune System, Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil degranulation, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Pertussis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), The NLRP3 inflammasome, Yersinia infection - Mus musculus (mouse)
UniProt: Q9EPB4
Entrez ID: 66824
|
Does Knockout of Pnp in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,547
|
Knockout
|
Pnp
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Pnp (purine-nucleoside phosphorylase)
Type: protein-coding
Summary: Enables guanosine phosphorylase activity and purine-nucleoside phosphorylase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleobase-containing small molecule metabolic process. Acts upstream of or within several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lymphocyte activation; and urate biosynthetic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study purine nucleoside phosphorylase deficiency. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: AMP catabolic process, AMP salvage, GMP catabolic process, GMP catabolic process to guanine, GMP salvage, GTP biosynthetic process, IMP catabolic process, IMP salvage, adenosine catabolic process, allantoin metabolic process, amide catabolic process, apoptotic mitochondrial changes, dAMP catabolic process, dGMP catabolic process, dGTP metabolic process, deoxyadenosine catabolic process, deoxyguanosine catabolic process, deoxyinosine catabolic process, guanosine catabolic process, immune response, inosine catabolic process, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of T cell apoptotic process, nicotinamide riboside catabolic process, nucleobase-containing compound metabolic process, nucleoside metabolic process, nucleotide biosynthetic process, positive regulation of B cell differentiation, positive regulation of DNA repair, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of alpha-beta T cell differentiation, positive regulation of interleukin-2 production, purine nucleoside metabolic process, purine ribonucleoside salvage, purine-containing compound salvage, response to gamma radiation, response to xenobiotic stimulus, urate biosynthetic process; MF: catalytic activity, glycosyltransferase activity, guanosine phosphorylase activity, identical protein binding, nucleoside binding, pentosyltransferase activity, phosphate ion binding, purine nucleobase binding, purine-nucleoside phosphorylase activity, transferase activity; CC: cytoplasm, cytosol, extracellular region
Pathways: Drug ADME, Immune System, Innate Immune System, Metabolism, Metabolism of nucleotides, Neutrophil degranulation, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nucleotide catabolism, Nucleotide salvage, Purine catabolism, Purine metabolism - Mus musculus (mouse), Purine salvage, Pyrimidine metabolism - Mus musculus (mouse), Ribavirin ADME, adenine and adenosine salvage I, adenine and adenosine salvage III, arsenate detoxification I (glutaredoxin), purine and pyrimidine metabolism, purine nucleotides degradation II (aerobic), purine ribonucleosides degradation to ribose-1-phosphate, urate biosynthesis/inosine 5,-phosphate degradation, ureide biosynthesis, xanthine and xanthosine salvage
UniProt: P23492
Entrez ID: 18950
|
Does Knockout of SDR42E2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
SDR42E2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sdr42e2 (short chain dehydrogenase/reductase family 42E, member 2)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Orthologous to human SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Pathways:
UniProt:
Entrez ID: 436008
|
Does Knockout of Tbx19 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Tbx19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tbx19 (T-box 19)
Type: protein-coding
Summary: This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: cell fate commitment, cell fate specification, heart morphogenesis, mesoderm formation, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of cell population proliferation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q99ME7
Entrez ID: 83993
|
Does Knockout of Ube2j2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ube2j2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2j2 (ubiquitin-conjugating enzyme E2J 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, protein K6-linked ubiquitination, protein polyubiquitination, protein ubiquitination, response to unfolded protein, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Protein localization, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q6P073
Entrez ID: 140499
|
Does Knockout of Upp2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Upp2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Upp2 (uridine phosphorylase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, UMP salvage, dCMP catabolic process, nucleoside metabolic process, nucleotide catabolic process, uridine catabolic process; MF: catalytic activity, deoxyuridine phosphorylase activity, glycosyltransferase activity, identical protein binding, pentosyltransferase activity, transferase activity, uridine phosphorylase activity; CC: cytoplasm, cytosol, type III intermediate filament
Pathways: (deoxy)ribose phosphate degradation, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Nucleotide salvage, Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage, salvage pathways of pyrimidine ribonucleotides
UniProt: Q8CGR7
Entrez ID: 76654
|
Does Knockout of Vmn1r75 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Vmn1r75
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Vmn1r75 (vomeronasal 1 receptor 75)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQG0, Q8R289
Entrez ID: 171241
|
Does Knockout of BC051665 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
BC051665
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: BC051665 (cDNA sequence BC051665)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen catabolic process, fusion of virus membrane with host endosome membrane, fusion of virus membrane with host plasma membrane, protein autoprocessing, proteolysis, proteolysis involved in protein catabolic process, receptor-mediated endocytosis of virus by host cell, symbiont entry into host cell, zymogen activation; MF: collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, fibronectin binding, histone binding, hydrolase activity, peptidase activity, proteoglycan binding, serpin family protein binding; CC: Golgi apparatus, extracellular space, lysosome, multivesicular body, plasma membrane
Pathways: Adaptive Immune System, Adherens junctions interactions, Assembly of collagen fibrils and other multimeric structures, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Collagen degradation, Collagen formation, Degradation of CDH1, Degradation of the extracellular matrix, Extracellular matrix organization, Gene expression (Transcription), Generic Transcription Pathway, Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Immune System, Innate Immune System, MHC class II antigen presentation, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Transcriptional regulation by RUNX1
UniProt: Q80X23, E9Q623, Q3ULD9
Entrez ID: 218275
|
Does Knockout of Ran in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Ran
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ran (RAN, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GTP metabolic process, actin cytoskeleton organization, cell division, cellular response to mineralocorticoid stimulus, glycolytic process, hippocampus development, intracellular protein localization, mitotic sister chromatid segregation, nucleocytoplasmic transport, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein localization to nucleolus, protein transport, protein-containing complex localization, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, snRNA import into nucleus, spermatid development; MF: G protein activity, GDP binding, GTP binding, GTPase activity, dynein intermediate chain binding, hydrolase activity, importin-alpha family protein binding, magnesium ion binding, metal ion binding, nucleotide binding, pre-miRNA binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding; CC: RNA nuclear export complex, centriole, chromatin, cytoplasm, cytosol, male germ cell nucleus, manchette, melanosome, midbody, nuclear envelope, nuclear pore, nucleolus, nucleoplasm, nucleus, protein-containing complex, recycling endosome, sperm flagellum
Pathways: Cell Cycle, Cell Cycle, Mitotic, Gene Silencing by RNA, Gene expression (Transcription), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), M Phase, Metabolism, Metabolism of lipids, Metabolism of steroids, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Postmitotic nuclear pore complex (NPC) reformation, Regulation of cholesterol biosynthesis by SREBP (SREBF), Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Transcriptional regulation by small RNAs
UniProt: P62827
Entrez ID: 19384
|
Does Knockout of Mlf2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Mlf2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mlf2 (myeloid leukemia factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, glutamatergic synapse, nucleus, synapse
Pathways:
UniProt: Q99KX1
Entrez ID: 30853
|
Does Knockout of Mrpl23 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Mrpl23
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mrpl23 (mitochondrial ribosomal protein L23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cytosolic ribosome, fibrillar center, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosomal subunit, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: O35972
Entrez ID: 19935
|
Does Knockout of Tmem233 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tmem233
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem233 (transmembrane protein 233)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: D3Z1U7
Entrez ID: 545798
|
Does Knockout of Igfbp2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Igfbp2
|
cell cycle progression
|
breast epithelium
|
Gene: Igfbp2 (insulin-like growth factor binding protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular response to hormone stimulus, female pregnancy, negative regulation of osteoblast differentiation, osteoblast differentiation, positive regulation of activated T cell proliferation, regulation of insulin-like growth factor receptor signaling pathway, response to estradiol, response to estrogen, response to glucocorticoid, response to mechanical stimulus, response to nutrient, response to retinoic acid, response to steroid hormone, response to xenobiotic stimulus; MF: growth factor binding, insulin-like growth factor I binding, insulin-like growth factor II binding, insulin-like growth factor binding, protein phosphatase inhibitor activity, receptor ligand inhibitor activity, signaling receptor inhibitor activity; CC: apical plasma membrane, extracellular region, extracellular space
Pathways: Metabolism of proteins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P47877
Entrez ID: 16008
|
Does Knockout of Hsdl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Hsdl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hsdl1 (hydroxysteroid dehydrogenase like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, steroid dehydrogenase activity; CC: intermediate filament cytoskeleton, mitochondrion
Pathways:
UniProt: Q8BTX9
Entrez ID: 72552
|
Does Knockout of Tnip2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tnip2
|
cell cycle progression
|
breast epithelium
|
Gene: Tnip2 (TNFAIP3 interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD40 signaling pathway, apoptotic process, cellular response to lipopolysaccharide, inflammatory response, interleukin-1-mediated signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of endothelial cell apoptotic process, positive regulation of B cell activation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macrophage activation, positive regulation of transcription by RNA polymerase II, protein stabilization, regulation of canonical NF-kappaB signal transduction, regulation of transcription by RNA polymerase II, toll-like receptor 2 signaling pathway, toll-like receptor 3 signaling pathway, toll-like receptor 9 signaling pathway; MF: K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, polyubiquitin modification-dependent protein binding, protein binding, protein kinase binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Cytokine Signaling in Immune system, Deubiquitination, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Ovarian tumor domain proteases, Post-translational protein modification, Signaling by Interleukins, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q99JG7
Entrez ID: 231130
|
Does Knockout of Rad51c in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,552
|
Knockout
|
Rad51c
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad51c (RAD51 paralog C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, female meiosis sister chromatid cohesion, male meiosis I, meiotic DNA recombinase assembly, positive regulation of G2/M transition of mitotic cell cycle, reciprocal meiotic recombination, sister chromatid cohesion, spermatogenesis, telomere maintenance via recombination; MF: ATP binding, ATP-dependent DNA damage sensor activity, DNA binding, crossover junction DNA endonuclease activity, four-way junction DNA binding, nucleotide binding, protein binding; CC: Holliday junction resolvase complex, Rad51B-Rad51C-Rad51D-XRCC2 complex, Rad51C-XRCC3 complex, cell junction, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Factors involved in megakaryocyte development and platelet production, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hemostasis, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q924H5
Entrez ID: 114714
|
Does Knockout of Pmfbp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pmfbp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pmfbp1 (polyamine modulated factor 1 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, intracellular protein localization, protein-containing complex assembly, regulation of protein localization, spermatid development, spermatogenesis; MF: molecular_function, protein binding; CC: cell projection, cilium, cytoplasm, motile cilium, sperm flagellum, sperm head, sperm head-tail coupling apparatus
Pathways:
UniProt: Q9WVQ0
Entrez ID: 56523
|
Does Knockout of Gm12887 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Gm12887
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm12887 (predicted gene 12887)
Type: protein-coding
Summary: predicted gene 12887
Gene Ontology:
Pathways:
UniProt: B1AVM1
Entrez ID: 666927
|
Does Knockout of Gm382 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Gm382
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm382 (predicted gene 382)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3V0S4
Entrez ID: 211208
|
Does Knockout of Cpsf2 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Cpsf2
|
response to virus
|
Microglial Cell Line
|
Gene: Cpsf2 (cleavage and polyadenylation specific factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing; MF: RNA binding; CC: glutamatergic synapse, mRNA cleavage and polyadenylation specificity factor complex, nucleus, postsynapse
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O35218
Entrez ID: 51786
|
Does Knockout of Prok2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Prok2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Prok2 (prokineticin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, chemotaxis, circadian rhythm, coronary vasculature development, endothelial cell proliferation, epicardium-derived cardiac endothelial cell differentiation, epicardium-derived cardiac vascular smooth muscle cell differentiation, negative regulation of apoptotic process, neuropeptide signaling pathway, positive regulation of smooth muscle contraction, rhythmic process, spermatogenesis, vasculogenesis involved in coronary vascular morphogenesis; MF: G protein-coupled receptor binding
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9QXU7
Entrez ID: 50501
|
Does Knockout of Scgb2b27 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Scgb2b27
|
cell cycle progression
|
breast epithelium
|
Gene: Scgb2b27 (secretoglobin, family 2B, member 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: A0A087WRN7, Q8R1E9
Entrez ID: 233099
|
Does Knockout of Dagla in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Dagla
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dagla (diacylglycerol lipase, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acylglycerol metabolic process, arachidonate metabolic process, cannabinoid biosynthetic process, diacylglycerol catabolic process, lipid catabolic process, lipid metabolic process, monoacylglycerol biosynthetic process, neuroblast proliferation, neurogenesis, regulation of neuroinflammatory response, retrograde trans-synaptic signaling by endocannabinoid; MF: hydrolase activity, lipoprotein lipase activity, metal ion binding, monoacylglycerol lipase activity, protein binding; CC: cell projection, cytoplasm, dendrite membrane, dendritic spine membrane, early endosome membrane, endosome, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse, varicosity
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Arachidonate production from DAG, Effects of PIP2 hydrolysis, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, Platelet activation, signaling and aggregation, Retrograde endocannabinoid signaling - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, triacylglycerol degradation
UniProt: Q6WQJ1
Entrez ID: 269060
|
Does Knockout of Zfp687 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zfp687
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp687 (zinc finger protein 687)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9D2D7
Entrez ID: 78266
|
Does Knockout of She in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
She
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: She (src homology 2 domain-containing transforming protein E)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BSD5
Entrez ID: 214547
|
Does Knockout of Cab39l in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Cab39l
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cab39l (calcium binding protein 39-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: AMPK signaling pathway - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, MTOR signalling, Signal Transduction, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9DB16
Entrez ID: 69008
|
Does Knockout of Trpv5 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Trpv5
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Trpv5 (transient receptor potential cation channel, subfamily V, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, calcium ion transport into cytosol, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, protein homotetramerization, regulation of urine volume, transmembrane transport; MF: calcium channel activity, calmodulin binding, metal ion binding, monoatomic ion channel activity, protein binding; CC: apical plasma membrane, calcium channel complex, membrane, plasma membrane
Pathways: Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Ion channel transport, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: P69744
Entrez ID: 194352
|
Does Knockout of G3bp2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
G3bp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: G3bp2 (G3BP stress granule assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, mRNA transport, protein homooligomerization, small GTPase-mediated signal transduction, stress granule assembly; MF: RNA binding, mRNA binding, molecular condensate scaffold activity, nucleic acid binding; CC: cytoplasm, cytoplasmic stress granule, cytosol
Pathways: cyclic AMP biosynthesis
UniProt: P97379
Entrez ID: 23881
|
Does Knockout of Spint2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Spint2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Spint2 (serine protease inhibitor, Kunitz type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basement membrane organization, epithelial cell morphogenesis involved in placental branching, establishment or maintenance of cell polarity, negative regulation of cell motility, negative regulation of cell-cell adhesion, negative regulation of neural precursor cell proliferation, neural tube closure; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane
Pathways: MET Receptor Activation, Signal Transduction, Signaling by MET, Signaling by MST1, Signaling by Receptor Tyrosine Kinases
UniProt: Q9WU03
Entrez ID: 20733
|
Does Knockout of Clca1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Clca1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Clca1 (chloride channel accessory 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transport, cellular response to hypoxia, chloride transmembrane transport, chloride transport, monoatomic ion transport, proteolysis; MF: chloride channel activity, hydrolase activity, intracellularly calcium-gated chloride channel activity, metal ion binding, metallopeptidase activity, peptidase activity; CC: extracellular region, membrane, microvillus, plasma membrane, secretory granule, zymogen granule membrane
Pathways: Ion channel transport, Pancreatic secretion - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: Q9D7Z6
Entrez ID: 23844
|
Does Knockout of Atp6v0d2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Atp6v0d2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Atp6v0d2 (ATPase, H+ transporting, lysosomal V0 subunit D2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, vacuolar acidification, vacuolar transport; CC: apical plasma membrane, early endosome, endosome, membrane, plasma membrane proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, vacuolar proton-transporting V-type ATPase complex
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q80SY3
Entrez ID: 242341
|
Does Knockout of Mettl16 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mettl16
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mettl16 (methyltransferase 16, N6-methyladenosine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, RNA modification, S-adenosylmethionine biosynthetic process, mRNA catabolic process, mRNA destabilization, mRNA processing, methylation, negative regulation of 3'-UTR-mediated mRNA stabilization, positive regulation of mRNA catabolic process, post-transcriptional regulation of gene expression, rRNA base methylation, regulation of mRNA splicing, via spliceosome, regulation of mRNA stability, snRNA (adenine-N6)-methylation; MF: RNA binding, RNA stem-loop binding, U6 snRNA (adenine-(43)-N(6))-methyltransferase activity, U6 snRNA 3'-end binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9CQG2
Entrez ID: 67493
|
Does Knockout of Trim11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Trim11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trim11 (tripartite motif-containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, host-mediated suppression of symbiont invasion, innate immune response, negative regulation of AIM2 inflammasome complex assembly, negative regulation of DNA-templated transcription, negative regulation of neurogenesis, negative regulation of viral transcription, positive regulation of viral entry into host cell, protein autoubiquitination, protein ubiquitination, regulation of gene expression, suppression of viral release by host; MF: metal ion binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, transcription factor binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q99PQ2
Entrez ID: 94091
|
Does Knockout of Actrt3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Actrt3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Actrt3 (actin related protein T3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: actin cytoskeleton, cytoplasm, cytoskeleton, male germ cell nucleus, nucleus
Pathways:
UniProt: Q8BXF8
Entrez ID: 76652
|
Does Knockout of Dnajc5g in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Dnajc5g
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dnajc5g (DnaJ heat shock protein family (Hsp40) member C5 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: A0A087WQK2, Q8C632, A0A087WSK1
Entrez ID: 231098
|
Does Knockout of P2rx2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
P2rx2
|
cell proliferation
|
Regulatory T cell
|
Gene: P2rx2 (purinergic receptor P2X, ligand-gated ion channel, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to pain, calcium ion transmembrane transport, chemical synaptic transmission, detection of hypoxic conditions in blood by carotid body chemoreceptor signaling, excitatory postsynaptic potential, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular junction development, neuromuscular synaptic transmission, neuronal action potential, peristalsis, positive regulation of transcription by RNA polymerase II, purinergic nucleotide receptor signaling pathway, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, response to ATP, response to carbohydrate, response to hypoxia, response to ischemia, sensory perception of sound, sensory perception of taste, skeletal muscle fiber development, urinary bladder smooth muscle contraction; MF: ATP binding, DNA-binding transcription activator activity, RNA polymerase II-specific, cadmium ion binding, cobalt ion binding, copper ion binding, extracellularly ATP-gated monoatomic cation channel activity, identical protein binding, ligand-gated monoatomic ion channel activity, mercury ion binding, monoatomic ion channel activity, nickel cation binding, nucleotide binding, phosphatidylinositol binding, protein-containing complex binding, purinergic nucleotide receptor activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, apical plasma membrane, cell surface, dendritic spine, glutamatergic synapse, membrane, neuronal cell body, neuronal dense core vesicle, parallel fiber to Purkinje cell synapse, plasma membrane, postsynapse, postsynaptic density membrane, presynaptic active zone membrane, presynaptic membrane, receptor complex, synapse, terminal bouton
Pathways: Calcium signaling pathway - Mus musculus (mouse), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Taste transduction - Mus musculus (mouse)
UniProt: Q8K3P1
Entrez ID: 231602
|
Does Knockout of Sap18 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Sap18
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sap18 (Sin3-associated polypeptide 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: protein binding, transcription corepressor activity; CC: ASAP complex, cytoplasm, cytosol, exon-exon junction complex, histone deacetylase complex, nuclear body, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O55128
Entrez ID: 20220
|
Does Knockout of Zdhhc12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Zdhhc12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zdhhc12 (zinc finger, DHHC domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated autophagy, gamma-aminobutyric acid receptor clustering, gephyrin clustering involved in postsynaptic density assembly, negative regulation of NLRP3 inflammasome complex assembly, peptidyl-L-cysteine S-palmitoylation, positive regulation of synaptic transmission, GABAergic, protein catabolic process, protein targeting to lysosome involved in chaperone-mediated autophagy, protein targeting to membrane, synaptic transmission, GABAergic; MF: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8VC90
Entrez ID: 66220
|
Does Knockout of Ccnl2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Ccnl2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ccnl2 (cyclin L2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJA7
Entrez ID: 56036
|
Does Knockout of Adh4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Adh4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Adh4 (alcohol dehydrogenase 4 (class II), pi polypeptide)
Type: protein-coding
Summary: Enables NADPH:quinone reductase activity; alcohol dehydrogenase (NAD+) activity; and aldose reductase (NADPH) activity. Involved in fatty acid omega-oxidation. Acts upstream of or within several processes, including alcohol catabolic process; ethanol metabolic process; and quinone metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adrenal cortex; genitourinary system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: alcohol catabolic process, alcohol metabolic process, aldehyde metabolic process, ethanol metabolic process, fatty acid omega-oxidation, formaldehyde catabolic process, lipid metabolic process, quinone metabolic process, retinoid metabolic process, retinol metabolic process, small molecule catabolic process; MF: NAD binding, S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity, alcohol dehydrogenase (NAD+) activity, aldose reductase (NADPH) activity, all-trans retinal binding, all-trans-retinol dehydrogenase (NAD+) activity, benzaldehyde dehydrogenase (NAD+) activity, metal ion binding, oxidoreductase activity, quinone reductase (NADPH) activity, retinol binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Alcoholic liver disease - Mus musculus (mouse), Biological oxidations, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Ethanol oxidation, Fatty acid degradation - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds, Pyruvate metabolism - Mus musculus (mouse), RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Tyrosine metabolism - Mus musculus (mouse), ethanol degradation II (cytosol), phenylalanine degradation III
UniProt: Q9QYY9
Entrez ID: 26876
|
Does Knockout of Oog2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Oog2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Oog2 (oogenesin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q7TPX8
Entrez ID: 381570
|
Does Knockout of Cep170 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cep170
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cep170 (centrosomal protein 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, spindle
Pathways:
UniProt: Q6A065
Entrez ID: 545389
|
Does Knockout of Smarca2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Smarca2
|
response to bacteria
|
renal medulla cell line
|
Gene: Smarca2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2)
Type: protein-coding
Summary: Predicted to enable several functions, including chromatin binding activity; nucleosome array spacer activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of fibroblast proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including early conceptus; genitourinary system; heart; telencephalon; and vitelline artery. Human ortholog(s) of this gene implicated in Nicolaides-Baraitser syndrome and blepharophimosis-impaired intellectual development syndrome. Orthologous to human SMARCA2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: aortic smooth muscle cell differentiation, chromatin organization, chromatin remodeling, hematopoietic stem cell homeostasis, heterochromatin formation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, nervous system development, nucleosome assembly, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: ATP binding, ATP hydrolysis activity, DNA binding, chromatin binding, histone binding, hydrolase activity, nucleosome array spacer activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity; CC: GBAF complex, SWI/SNF complex, bBAF complex, brahma complex, chromatin, intermediate filament cytoskeleton, nBAF complex, npBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q6DIC0
Entrez ID: 67155
|
Does Knockout of Il12rb1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Il12rb1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Il12rb1 (interleukin 12 receptor, beta 1)
Type: protein-coding
Summary: Contributes to cytokine binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in external side of plasma membrane. Part of interleukin-23 receptor complex. Is expressed in craniocervical region bone; male reproductive gland or organ; and rib. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T-helper 1 cell differentiation, cellular response to type II interferon, cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, positive regulation of T-helper 1 type immune response, positive regulation of activated T cell proliferation, positive regulation of cell population proliferation, positive regulation of defense response to virus by host, positive regulation of type II interferon production; MF: coreceptor activity, cytokine binding, cytokine receptor activity, interleukin-12 receptor activity, interleukin-12 receptor binding, interleukin-23 binding, interleukin-23 receptor activity; CC: external side of plasma membrane, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q60837
Entrez ID: 16161
|
Does Knockout of Ebp in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ebp
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ebp (EBP cholestenol delta-isomerase)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embryonic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, hemopoiesis, lipid metabolic process, ossification involved in bone maturation, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol metabolic process; MF: C-8 sterol isomerase activity, cholestenol delta-isomerase activity, cholesterol-5,6-oxide hydrolase activity, hydrolase activity, identical protein binding, intramolecular oxidoreductase activity, transposing C=C bonds, isomerase activity, steroid Delta-isomerase activity; CC: cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, nuclear envelope, nuclear membrane, nucleus
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: P70245
Entrez ID: 13595
|
Does Knockout of Epdr1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Epdr1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Epdr1 (ependymin related 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-matrix adhesion, myofibroblast contraction; MF: calcium ion binding, ganglioside GM1 binding, identical protein binding, lipid binding, phospholipid binding; CC: extracellular region, lysosomal lumen, lysosome
Pathways:
UniProt: Q99M71
Entrez ID: 105298
|
Does Knockout of Rpf2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,261
|
Knockout
|
Rpf2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rpf2 (ribosome production factor 2 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), protein localization to nucleolus, rRNA processing, regulation of signal transduction by p53 class mediator, regulation of transcription by RNA polymerase II, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: 5S rRNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, rRNA binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJ80
Entrez ID: 67239
|
Does Knockout of Gmps in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Gmps
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gmps (guanine monophosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GMP biosynthetic process, GMP salvage, purine nucleotide biosynthetic process, response to L-cysteine; MF: ATP binding, GMP synthase (glutamine-hydrolyzing) activity, GMP synthase activity, enzyme binding, ligase activity, nucleotide binding; CC: cytoplasm, cytosol
Pathways: Azathioprine ADME, Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis
UniProt: Q3THK7
Entrez ID: 229363
|
Does Knockout of Rcc1l in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rcc1l
|
response to virus
|
Microglial Cell Line
|
Gene: Rcc1l (reculator of chromosome condensation 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: guanyl-nucleotide exchange factor activity, protein binding, rRNA binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9CYF5
Entrez ID: 94254
|
Does Knockout of Cmas in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Cmas
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cmas (cytidine monophospho-N-acetylneuraminic acid synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP-N-acetylneuraminate biosynthetic process, N-acetylneuraminate metabolic process, glycosylation; MF: N-acylneuraminate cytidylyltransferase activity, nucleotidyltransferase activity, transferase activity; CC: nucleoplasm, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q99KK2
Entrez ID: 12764
|
Does Knockout of Rbpj in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 167
|
Knockout
|
Rbpj
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rbpj (recombination signal binding protein for immunoglobulin kappa J region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, Notch signaling pathway, Sertoli cell proliferation, angiogenesis, animal organ development, aortic valve development, arterial endothelial cell fate commitment, artery morphogenesis, atrioventricular canal development, auditory receptor cell fate commitment, blood vessel endothelial cell fate specification, blood vessel lumenization, blood vessel remodeling, cardiac left ventricle morphogenesis, cardiac muscle cell fate commitment, cardiac muscle cell myoblast differentiation, cell fate commitment, club cell differentiation, defense response to bacterium, determination of heart left/right asymmetry, dorsal aorta morphogenesis, endocardium development, endocardium morphogenesis, epidermal cell fate specification, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, hair follicle maturation, heart development, heart induction, heart looping, hemopoiesis, humoral immune response, inflammatory response to antigenic stimulus, keratinocyte differentiation, labyrinthine layer blood vessel development, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of cold-induced thermogenesis, negative regulation of neuron projection development, negative regulation of ossification, negative regulation of smooth muscle cell apoptotic process, negative regulation of smooth muscle cell migration, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, neuron differentiation, outflow tract morphogenesis, pituitary gland development, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of ERBB signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cardiac muscle cell proliferation, positive regulation of cell proliferation involved in heart morphogenesis, positive regulation of ephrin receptor signaling pathway, positive regulation of epithelial cell proliferation, positive regulation of gene expression, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of Notch receptor target, pulmonary valve development, regulation of DNA-templated transcription, regulation of cell adhesion involved in heart morphogenesis, regulation of epithelial cell proliferation, regulation of gene expression, regulation of generation of precursor metabolites and energy, regulation of timing of cell differentiation, regulation of transcription by RNA polymerase II, sebaceous gland development, secondary heart field specification, somatic stem cell population maintenance, somitogenesis, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, protein-containing complex binding, sequence-specific DNA binding; CC: MAML1-RBP-Jkappa- ICN1 complex, cytoplasm, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex, transcription repressor complex
Pathways: Epstein-Barr virus infection - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Mus musculus (mouse), NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Spinocerebellar ataxia - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Transcriptional regulation by RUNX3, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P31266
Entrez ID: 19664
|
Does Knockout of Atp23 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Atp23
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Atp23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial protein processing, mitochondrial proton-transporting ATP synthase complex assembly, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function, peptidase activity; CC: cell junction, cytosol, mitochondrion, plasma membrane
Pathways:
UniProt: Q9CWQ3
Entrez ID: 68876
|
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