prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Abca12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Abca12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Abca12 (ATP-binding cassette, sub-family A member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide metabolic process, ceramide transport, corneocyte desquamation, establishment of localization in cell, establishment of skin barrier, intracellular protein transport, keratinization, keratinocyte differentiation, lipid homeostasis, lipid translocation, lipid transport, lung alveolus development, phospholipid efflux, positive regulation of cholesterol efflux, positive regulation of cholesterol transport, positive regulation of intracellular lipid transport, positive regulation of protein localization to cell surface, protein localization to plasma membrane, regulated exocytosis, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of keratinocyte differentiation, secretion by cell, skin morphogenesis, surfactant homeostasis, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, apolipoprotein A-I receptor binding, lipid transporter activity, nucleotide binding, protein binding, signaling receptor binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, epidermal lamellar body, epidermal lamellar body membrane, intracellular membrane-bounded organelle, membrane, mitochondrial inner membrane, plasma membrane, transport vesicle membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Transport of small molecules
UniProt: E9Q876
Entrez ID: 74591
|
Does Knockout of Cox7b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cox7b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cox7b (cytochrome c oxidase subunit 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: P56393
Entrez ID: 66142
|
Does Knockout of Pvalb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Pvalb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pvalb (parvalbumin)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and identical protein binding activity. Involved in excitatory chemical synaptic transmission; gene expression; and inhibitory chemical synaptic transmission. Located in axon and cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human PVALB (parvalbumin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: excitatory chemical synaptic transmission, gene expression, inhibitory chemical synaptic transmission; MF: calcium ion binding, identical protein binding, metal ion binding, protein-containing complex binding; CC: axon, cuticular plate, cytoplasm, cytosol, neuronal cell body, protein-containing complex, stereocilium, synapse
Pathways:
UniProt: P32848
Entrez ID: 19293
|
Does Knockout of Gm21815 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gm21815
|
phagocytosis
|
macrophage
|
Gene: Gm21815 (predicted gene, 21815)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nipal2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Nipal2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Nipal2 (NIPA-like domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion transmembrane transport, magnesium ion transport; MF: magnesium ion transmembrane transporter activity, molecular_function; CC: membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q91WC7
Entrez ID: 223473
|
Does Knockout of Cops7a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Cops7a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cops7a (COP9 signalosome subunit 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COP9 signalosome assembly, protein deneddylation; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q9CZ04
Entrez ID: 26894
|
Does Knockout of Nos1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Nos1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nos1 (nitric oxide synthase 1, neuronal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine catabolic process, behavioral response to cocaine, cell communication, cellular response to epinephrine stimulus, cellular response to growth factor stimulus, cellular response to mechanical stimulus, establishment of localization in cell, establishment of protein localization, multicellular organismal response to stress, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of calcium ion transport, negative regulation of cell population proliferation, negative regulation of cytosolic calcium ion concentration, negative regulation of hepatic stellate cell contraction, negative regulation of insulin secretion, negative regulation of iron ion transmembrane transport, negative regulation of neuron apoptotic process, negative regulation of potassium ion transport, negative regulation of serotonin uptake, negative regulation of vasoconstriction, nitric oxide biosynthetic process, nitric oxide mediated signal transduction, nitric oxide-cGMP-mediated signaling, positive regulation of DNA-templated transcription, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway, positive regulation of long-term synaptic potentiation, positive regulation of neuron apoptotic process, positive regulation of sodium ion transmembrane transport, positive regulation of the force of heart contraction, positive regulation of transcription by RNA polymerase II, regulation of neurogenesis, regulation of postsynaptic membrane potential, regulation of sodium ion transport, regulation of the force of heart contraction, response to estrogen, response to heat, response to hormone, response to hypoxia, response to lipopolysaccharide, response to peptide hormone, signaling, striated muscle contraction, synaptic signaling by nitric oxide, system process, vasodilation, xenobiotic catabolic process; MF: ATPase binding, FMN binding, NADP binding, NADPH binding, RNA polymerase II-specific DNA-binding transcription factor binding, cadmium ion binding, calcium-dependent protein binding, calmodulin binding, enzyme binding, flavin adenine dinucleotide binding, heme binding, identical protein binding, metal ion binding, nitric-oxide synthase activity, oxidoreductase activity, peptidyl-cysteine S-nitrosylase activity, phosphoprotein binding, protein binding, scaffold protein binding, sodium channel regulator activity, transmembrane transporter binding, zinc ion binding; CC: T-tubule, Z disc, azurophil granule, calyx of Held, caveola, cell periphery, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, endomembrane system, glutamatergic synapse, membrane, membrane raft, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, photoreceptor inner segment, plasma membrane, postsynaptic density, postsynaptic density, intracellular component, postsynaptic specialization, intracellular component, protein-containing complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, secretory granule, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Circadian entrainment - Mus musculus (mouse), Hemostasis, Immune System, Innate Immune System, Ion homeostasis, Long-term depression - Mus musculus (mouse), Muscle contraction, Nitric oxide stimulates guanylate cyclase, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet homeostasis, ROS and RNS production in phagocytes, Relaxin signaling pathway - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), citrulline-nitric oxide cycle, superpathway of citrulline metabolism
UniProt: Q9Z0J4
Entrez ID: 18125
|
Does Knockout of Spam1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Spam1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Spam1 (sperm adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell adhesion, fusion of sperm to egg plasma membrane involved in single fertilization, hyaluronan catabolic process, single fertilization; MF: hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds; CC: acrosomal vesicle, external side of plasma membrane, membrane, membrane raft, plasma membrane, side of membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Lysosome - Mus musculus (mouse)
UniProt: P48794
Entrez ID: 20690
|
Does Knockout of Tcaim in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Tcaim
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tcaim (T cell activation inhibitor, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q66JZ4
Entrez ID: 382117
|
Does Knockout of Mtrf1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Mtrf1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mtrf1 (mitochondrial translational release factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational termination, translation, translational termination; MF: translation release factor activity, translation release factor activity, codon specific; CC: cytoplasm, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q8K126
Entrez ID: 211253
|
Does Knockout of Btnl6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Btnl6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Btnl6 (butyrophilin-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, extrathymic T cell selection, regulation of cytokine production; MF: signaling receptor binding, zinc ion binding; CC: cytoplasm, external side of plasma membrane, membrane
Pathways:
UniProt: A2CG22
Entrez ID: 624681
|
Does Knockout of Epo in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Epo
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Epo (erythropoietin)
Type: protein-coding
Summary: This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: acute-phase response, angiogenesis, apoptotic process, cardiac muscle tissue morphogenesis, cell surface receptor signaling pathway via STAT, cellular hyperosmotic response, embryo implantation, erythrocyte differentiation, erythrocyte maturation, erythropoietin-mediated signaling pathway, heart morphogenesis, hemoglobin biosynthetic process, negative regulation of apoptotic process, negative regulation of calcium ion transport into cytosol, negative regulation of erythrocyte apoptotic process, negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress, negative regulation of myeloid cell apoptotic process, negative regulation of transcription by RNA polymerase II, peptidyl-serine phosphorylation, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of Ras protein signal transduction, positive regulation of activated T cell proliferation, positive regulation of cell population proliferation, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of protein kinase activity, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II, response to axon injury, response to dexamethasone, response to electrical stimulus, response to estrogen, response to hyperoxia, response to hypoxia, response to interleukin-1, response to lipopolysaccharide, response to nutrient, response to salt stress, response to stress, response to testosterone, response to vitamin A, vasculogenesis involved in coronary vascular morphogenesis, ventricular cardiac muscle tissue morphogenesis, visceral serous pericardium development; MF: cytokine activity, erythropoietin receptor binding, hormone activity, protein kinase activator activity; CC: cell body, cell surface, extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, HIF-1 signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Erythropoietin
UniProt: P07321
Entrez ID: 13856
|
Does Knockout of Hsf4 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Hsf4
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Hsf4 (heat shock transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lens fiber cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein phosphatase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nuclear speck, nucleus
Pathways:
UniProt: Q9R0L1
Entrez ID: 26386
|
Does Knockout of Dpysl5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Dpysl5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dpysl5 (dihydropyrimidinase-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, negative regulation of dendrite morphogenesis, neuron differentiation, pyrimidine nucleobase catabolic process; MF: dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, protein binding; CC: cytoplasm, cytosol, dendrite, glutamatergic synapse, neuronal cell body, protein-containing complex, synapse
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), CRMPs in Sema3A signaling, Developmental Biology, Nervous system development, Semaphorin interactions
UniProt: Q9EQF6
Entrez ID: 65254
|
Does Knockout of Prr5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Prr5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Prr5 (proline rich 5 (renal))
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5 (proline rich 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: TORC2 signaling, actin cytoskeleton organization, cellular response to nutrient levels, cytoskeleton organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; CC: TORC2 complex
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Co-stimulation by CD28, Gene expression (Transcription), Generic Transcription Pathway, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q812A5
Entrez ID: 109270
|
Does Knockout of Fthl17c in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Fthl17c
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Fthl17c (ferritin, heavy polypeptide-like 17, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular iron ion homeostasis, iron ion transport; MF: ferric iron binding, ferrous iron binding, metal ion binding
Pathways:
UniProt: A2AHC6
Entrez ID: 434727
|
Does Knockout of Insig2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Insig2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Insig2 (insulin induced gene 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, SREBP signaling pathway, SREBP-SCAP complex retention in endoplasmic reticulum, cellular response to insulin stimulus, cholesterol biosynthetic process, cholesterol metabolic process, cranial suture morphogenesis, inner ear morphogenesis, lipid metabolic process, middle ear morphogenesis, negative regulation of fatty acid biosynthetic process, negative regulation of steroid biosynthetic process, positive regulation of cholesterol biosynthetic process, protein maturation, response to fatty acid, response to insulin, response to lipid, response to sterol depletion, roof of mouth development, steroid metabolic process, sterol biosynthetic process, triglyceride metabolic process; MF: lipid binding, oxysterol binding, protein binding, protein sequestering activity; CC: SREBP-SCAP-Insig complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q91WG1
Entrez ID: 72999
|
Does Knockout of C330018D20Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
C330018D20Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: C330018D20Rik (RIKEN cDNA C330018D20 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CWB7
Entrez ID: 77422
|
Does Knockout of Tuba4a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Tuba4a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tuba4a (tubulin, alpha 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, enzyme binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein kinase binding, structural constituent of cytoskeleton; CC: cilium, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Recycling pathway of L1, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Response to elevated platelet cytosolic Ca2+, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P68368
Entrez ID: 22145
|
Does Knockout of Smarcb1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,538
|
Knockout
|
Smarcb1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Smarcb1 (SWI/SNF related BAF chromatin remodeling complex subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, blastocyst development, blastocyst hatching, chromatin organization, chromatin remodeling, hepatocyte differentiation, host-mediated activation of viral transcription, negative regulation of cell population proliferation, nervous system development, nucleosome disassembly, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of glucose mediated signaling pathway, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, single stranded viral RNA replication via double stranded DNA intermediate, transcription initiation-coupled chromatin remodeling; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, Tat protein binding, identical protein binding, p53 binding, protein binding, transcription coactivator activity; CC: RSC-type complex, SWI/SNF complex, XY body, bBAF complex, brahma complex, chromatin, fibrillar center, germ cell nucleus, kinetochore, nBAF complex, npBAF complex, nuclear chromosome, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q9Z0H3
Entrez ID: 20587
|
Does Knockout of Wnt7a in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Wnt7a
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Wnt7a (wingless-type MMTV integration site family, member 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, angiogenesis, animal organ morphogenesis, asymmetric protein localization involved in cell fate determination, canonical Wnt signaling pathway, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell proliferation in forebrain, cell-cell signaling, cellular response to transforming growth factor beta stimulus, central nervous system vasculogenesis, cerebellar granule cell differentiation, chondrocyte differentiation, dendritic spine morphogenesis, dorsal/ventral pattern formation, embryonic axis specification, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, establishment of blood-brain barrier, establishment of cell polarity, limb development, negative regulation of apoptotic process, negative regulation of neurogenesis, neuron differentiation, neurotransmitter secretion, non-canonical Wnt signaling pathway, oviduct development, positive regulation of DNA-templated transcription, positive regulation of JNK cascade, positive regulation of cell population proliferation, positive regulation of endothelial cell migration, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of excitatory postsynaptic potential, positive regulation of excitatory synapse assembly, positive regulation of gene expression, positive regulation of protein metabolic process, positive regulation of synapse assembly, positive regulation of transcription by RNA polymerase II, regulation of axon diameter, regulation of axonogenesis, regulation of cell population proliferation, regulation of epithelial cell proliferation, regulation of postsynapse organization, regulation of presynapse assembly, regulation of synaptic vesicle exocytosis, response to estradiol, response to estrogen, secondary palate development, signal transduction, skeletal muscle satellite cell activation, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, somatic stem cell division, somatic stem cell population maintenance, stem cell development, synapse organization, system development, tissue development, uterus development, uterus morphogenesis, wound healing, spreading of epidermal cells; MF: cytokine activity, frizzled binding, receptor ligand activity, signaling receptor binding; CC: Schaffer collateral - CA1 synapse, cell surface, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, presynapse
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), WNT ligand biogenesis and trafficking, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P24383
Entrez ID: 22421
|
Does Knockout of Prkcg in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Prkcg
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Prkcg (protein kinase C, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, chemosensory behavior, innervation, intracellular signal transduction, learning or memory, long-term synaptic potentiation, negative regulation of neuron apoptotic process, negative regulation of proteasomal protein catabolic process, negative regulation of protein catabolic process, negative regulation of protein ubiquitination, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of mismatch repair, presynaptic modulation of chemical synaptic transmission, regulation of circadian rhythm, regulation of phagocytosis, regulation of response to food, regulation of synaptic vesicle exocytosis, response to angiotensin, response to morphine, response to pain, response to psychosocial stress, response to toxic substance, rhythmic process, synaptic signaling via neuropeptide; MF: ATP binding, calcium,diacylglycerol-dependent serine/threonine kinase activity, diacylglycerol-dependent serine/threonine kinase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity, zinc ion binding; CC: calyx of Held, cell projection, cell-cell junction, cytoplasm, cytosol, dendrite, membrane, neuron projection, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic cytosol, postsynaptic density, presynaptic cytosol, synapse, synaptic membrane
Pathways: African trypanosomiasis - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Beta-catenin independent WNT signaling, Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), DAG and IP3 signaling, Diabetic cardiomyopathy - Mus musculus (mouse), Disinhibition of SNARE formation, Dopaminergic synapse - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G alpha (i) signalling events, G-protein mediated events, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Intracellular signaling by second messengers, Leukocyte transendothelial migration - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neutrophil extracellular trap formation - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), PCP/CE pathway, PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Platelet activation, signaling and aggregation, Proteoglycans in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), WNT5A-dependent internalization of FZD4, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P63318
Entrez ID: 18752
|
Does Knockout of Chtf18 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Chtf18
|
response to virus
|
Microglial Cell Line
|
Gene: Chtf18 (CTF18, chromosome transmission fidelity factor 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, germ cell development, male meiotic nuclear division, negative regulation of chromosome segregation, positive regulation of DNA-directed DNA polymerase activity, reciprocal meiotic recombination; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, nucleotide binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, cytoplasm, cytosol, male germ cell nucleus, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance
UniProt: Q8BIW9
Entrez ID: 214901
|
Does Knockout of Zfp933 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Zfp933
|
response to virus
|
Microglial Cell Line
|
Gene: Zfp933 (zinc finger protein 933)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in forelimb bud. Orthologous to human ZNF333 (zinc finger protein 333). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q3V2G0, Q6PEE4
Entrez ID: 242747
|
Does Knockout of Qtrt2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Qtrt2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Qtrt2 (queuine tRNA-ribosyltransferase accessory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA binding, tRNA-guanosine(34) queuine transglycosylase activity, zinc ion binding; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: B8ZXI1
Entrez ID: 106248
|
Does Knockout of Alg8 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Alg8
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Alg8 (ALG8 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q6P8H8
Entrez ID: 381903
|
Does Knockout of Itln1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Itln1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Itln1 (intelectin 1 (galactofuranose binding))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of D-glucose import, positive regulation of protein phosphorylation, response to nematode; MF: calcium ion binding, carbohydrate binding, identical protein binding, metal ion binding, oligosaccharide binding; CC: brush border membrane, extracellular matrix, extracellular region, extracellular space, membrane, membrane raft, plasma membrane, receptor complex, side of membrane
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: O88310
Entrez ID: 16429
|
Does Knockout of Anxa10 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Anxa10
|
phagocytosis
|
macrophage
|
Gene: Anxa10 (annexin A10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, calcium-dependent phospholipid binding, phosphatidylserine binding; CC: cytoplasm, mitochondrion, nucleus, plasma membrane, vesicle membrane
Pathways:
UniProt: Q9QZ10
Entrez ID: 26359
|
Does Knockout of Tm6sf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tm6sf1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tm6sf1 (transmembrane 6 superfamily member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: lysosomal membrane, lysosome, membrane
Pathways:
UniProt: P58749
Entrez ID: 107769
|
Does Knockout of Zfp616 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Zfp616
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zfp616 (zinc finger protein 616)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: A7DTG8, J3QN14, Q5SVV3
Entrez ID: 327963
|
Does Knockout of Nkain3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Nkain3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nkain3 (Na+/K+ transporting ATPase interacting 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q3URJ8
Entrez ID: 269513
|
Does Knockout of Trp53i13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Trp53i13
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Trp53i13 (transformation related protein 53 inducible protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell cycle, response to UV, response to xenobiotic stimulus; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q5F267
Entrez ID: 216964
|
Does Knockout of Ccnd3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Ccnd3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccnd3 (cyclin D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, T cell proliferation, cell division, hyaluronan biosynthetic process, negative regulation of transcription by RNA polymerase II, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, regulation of cell cycle, regulation of cell population proliferation, response to peptide hormone, signal transduction; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding, protein serine/threonine kinase activator activity; CC: cyclin D3-CDK4 complex, cyclin D3-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, microtubule organizing center, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cyclin D associated events in G1, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Measles - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of RUNX1 Expression and Activity, Signal Transduction, Transcriptional regulation by RUNX1, Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P30282
Entrez ID: 12445
|
Does Knockout of Fubp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Fubp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fubp3 (far upstream element (FUSE) binding protein 3)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA-templated transcription; intracellular mRNA localization; and positive regulation of macromolecule biosynthetic process. Predicted to be located in several cellular components, including dendritic shaft; neuronal cell body; and ribosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, intracellular mRNA localization, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: RNA binding, mRNA binding, nucleic acid binding, single-stranded DNA binding; CC: cytoplasm, dendritic shaft, neuronal cell body, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: A2AJ72, Q3TIX6, Q8BYI4, F6W2V3, A0A0A6YX76, A0A0A6YY39, A0A0A6YVV5, A0A0A6YW42, F7AM43, A2AJ71
Entrez ID: 320267
|
Does Knockout of Cyp4a12a in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Cyp4a12a
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Cyp4a12a (cytochrome P450, family 4, subfamily a, polypeptide 12a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, icosanoid biosynthetic process, kidney development, lauric acid metabolic process, linoleic acid metabolic process, omega-hydroxylase P450 pathway; MF: 16-hydroxypalmitate dehydrogenase activity, alkane 1-monooxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, arachidonate omega-hydroxylase activity, fatty acid omega-hydroxylase activity, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, medium-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acids, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, PPAR signaling pathway - Mus musculus (mouse), Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Vascular smooth muscle contraction - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q91WL5
Entrez ID: 277753
|
Does Knockout of Wdr46 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 1
| 1,839
|
Knockout
|
Wdr46
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Wdr46 (WD repeat domain 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis; CC: nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Z0H1
Entrez ID: 57315
|
Does Knockout of Elovl2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Elovl2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Elovl2 (ELOVL fatty acid elongase 2)
Type: protein-coding
Summary: Enables fatty acid elongase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within very long-chain fatty acid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; liver; paravertebral ganglion; sensory organ; and urinary system. Orthologous to human ELOVL2 (ELOVL fatty acid elongase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: alpha-linolenic acid metabolic process, fatty acid biosynthetic process, fatty acid derivative biosynthetic process, fatty acid elongation, monounsaturated fatty acid, fatty acid elongation, polyunsaturated fatty acid, fatty acid elongation, saturated fatty acid, fatty acid metabolic process, linoleic acid metabolic process, lipid biosynthetic process, lipid metabolic process, long-chain fatty acid biosynthetic process, sphingolipid biosynthetic process, unsaturated fatty acid biosynthetic process, very long-chain fatty acid biosynthetic process, very long-chain fatty acid metabolic process; MF: acyltransferase activity, transferring groups other than amino-acyl groups, fatty acid elongase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs, alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: Q9JLJ4
Entrez ID: 54326
|
Does Knockout of Atp6v1e1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Atp6v1e1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atp6v1e1 (ATPase, H+ transporting, lysosomal V1 subunit E1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, extrinsic component of synaptic vesicle membrane, membrane, microvillus, mitochondrion, plasma membrane, proton-transporting two-sector ATPase complex, catalytic domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P50518
Entrez ID: 11973
|
Does Knockout of Mettl25 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mettl25
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mettl25 (methyltransferase like 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, methylation; MF: methyltransferase activity, molecular_function, transferase activity
Pathways:
UniProt: Q6NXH8
Entrez ID: 216292
|
Does Knockout of Arl14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Arl14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Arl14 (ADP-ribosylation factor-like 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of cell polarity, intracellular protein transport, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytoplasmic vesicle, plasma membrane
Pathways:
UniProt: S4R1T9
Entrez ID: 71619
|
Does Knockout of Slc35c2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Slc35c2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc35c2 (solute carrier family 35, member C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-glucose transmembrane transport, negative regulation of gene expression, positive regulation of Notch signaling pathway, protein O-linked glycosylation via fucose; CC: Golgi apparatus, cis-Golgi network, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleoplasm
Pathways:
UniProt: Q8VCX2
Entrez ID: 228875
|
Does Knockout of Spag4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Spag4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Spag4 (sperm associated antigen 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis; MF: identical protein binding, protein-membrane adaptor activity; CC: cell projection, cilium, cytoplasm, cytoskeleton, meiotic nuclear membrane microtubule tethering complex, membrane, microtubule, motile cilium, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q9JJF2
Entrez ID: 245865
|
Does Knockout of Sgip1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Sgip1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sgip1 (SH3-domain GRB2-like (endophilin) interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, energy homeostasis, plasma membrane tubulation, positive regulation of eating behavior, positive regulation of feeding behavior, positive regulation of multicellular organism growth, positive regulation of receptor-mediated endocytosis, response to dietary excess, synaptic vesicle endocytosis; MF: SH3 domain binding, microtubule binding, phospholipid binding, protein binding, tubulin binding; CC: AP-2 adaptor complex, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, membrane, plasma membrane, presynapse
Pathways:
UniProt: Q8VD37
Entrez ID: 73094
|
Does Knockout of Tank in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tank
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tank (TRAF family member-associated Nf-kappa B activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cellular response to interleukin-1, cellular response to ionizing radiation, cellular response to tumor necrosis factor, negative regulation of canonical NF-kappaB signal transduction, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein deubiquitination, positive regulation of type I interferon production, positive regulation of ubiquitin-specific protease activity; MF: cysteine-type deubiquitinase activity, deubiquitinase activator activity, metal ion binding, molecular adaptor activity, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Immune System, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades
UniProt: P70347
Entrez ID: 21353
|
Does Knockout of Arhgef10l in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Arhgef10l
|
cell proliferation
|
Regulatory T cell
|
Gene: Arhgef10l (Rho guanine nucleotide exchange factor 10-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SREBP signaling pathway, actin cytoskeleton organization, positive regulation of stress fiber assembly, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity; CC: cytoplasm, cytosol
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: A2AWP8
Entrez ID: 72754
|
Does Knockout of Bbs9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Bbs9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Bbs9 (Bardet-Biedl syndrome 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, fat cell differentiation, protein localization to cilium, protein transport; CC: BBSome, cell projection, centriolar satellite, ciliary basal body, ciliary membrane, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nucleoplasm, pericentriolar material, plasma membrane
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q811G0
Entrez ID: 319845
|
Does Knockout of Ssc5d in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Ssc5d
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Ssc5d (scavenger receptor cysteine rich family, 5 domains)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, detection of bacterial lipoprotein, immune system process, innate immune response, negative regulation of interleukin-8 production, regulation of interleukin-8 production, vesicle-mediated transport; MF: extracellular matrix binding, fibronectin binding, laminin binding, protein binding, scavenger receptor activity; CC: cytoplasm, extracellular matrix, extracellular region, extracellular space, membrane
Pathways:
UniProt: Q8BV57
Entrez ID: 269855
|
Does Knockout of Gcnt2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gcnt2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gcnt2 (glucosaminyl (N-acetyl) transferase 2 (I blood group))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of lens transparency, negative regulation of cell-substrate adhesion, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of heterotypic cell-cell adhesion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, post-transcriptional regulation of gene expression, protein glycosylation, transforming growth factor beta receptor signaling pathway; MF: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity, acetylglucosaminyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: P97402
Entrez ID: 14538
|
Does Knockout of Slc25a51 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Slc25a51
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Slc25a51 (solute carrier family 25, member 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process via the salvage pathway, NADP+ biosynthetic process, aerobic electron transport chain, mitochondrial NAD transmembrane transport, nicotinamide riboside metabolic process; MF: NAD transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate metabolism
UniProt: Q5HZI9
Entrez ID: 230125
|
Does Knockout of Ccdc85c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Ccdc85c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccdc85c (coiled-coil domain containing 85C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, cell population proliferation, cerebral cortex development, establishment of cell polarity, establishment of protein localization, radial glial cell differentiation; MF: molecular_function, protein binding; CC: adherens junction, anchoring junction, apical junction complex, bicellular tight junction, cell junction, nuclear speck
Pathways:
UniProt: E9Q6B2
Entrez ID: 668158
|
Does Knockout of Gpr119 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Gpr119
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gpr119 (G-protein coupled receptor 119)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, insulin secretion, signal transduction; MF: G protein-coupled receptor activity, lipid binding, phosphatidylcholine binding; CC: cytoplasm, membrane, plasma membrane, receptor complex
Pathways: Incretin synthesis, secretion, and inactivation, Insulin secretion - Mus musculus (mouse), Metabolism of proteins, Peptide hormone metabolism, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q7TQP3
Entrez ID: 236781
|
Does Knockout of Abcc3 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Abcc3
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Abcc3 (ATP-binding cassette, sub-family C member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, canalicular bile acid transport, glucuronoside transport, leukotriene transport, lipid transport, monoatomic anion transmembrane transport, transmembrane transport, xenobiotic transmembrane transport, xenobiotic transport; MF: ABC-type bile acid transporter activity, ABC-type glutathione S-conjugate transporter activity, ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, glucuronoside transmembrane transporter activity, icosanoid transmembrane transporter activity, nucleotide binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: basal plasma membrane, basolateral plasma membrane, ciliary basal body, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Aspirin ADME, Bile acid and bile salt metabolism, Bile secretion - Mus musculus (mouse), Drug ADME, Metabolism, Metabolism of lipids, Metabolism of steroids, Paracetamol ADME, Recycling of bile acids and salts, Transport of small molecules
UniProt: B2RX12
Entrez ID: 76408
|
Does Knockout of Trpm4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Trpm4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Trpm4 (transient receptor potential cation channel, subfamily M, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to ATP, dendritic cell chemotaxis, immune system process, inorganic cation transmembrane transport, long-term memory, membrane depolarization during AV node cell action potential, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during bundle of His cell action potential, metal ion transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of bone mineralization, negative regulation of osteoblast differentiation, positive regulation of adipose tissue development, positive regulation of atrial cardiac muscle cell action potential, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of fat cell differentiation, positive regulation of heart rate, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization, positive regulation of vasoconstriction, protein homotetramerization, protein sumoylation, regulation of T cell cytokine production, regulation of heart rate by cardiac conduction, regulation of membrane potential, regulation of ventricular cardiac muscle cell action potential, sodium ion import across plasma membrane, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, calcium-activated cation channel activity, calmodulin binding, identical protein binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, nucleotide binding, voltage-gated monoatomic ion channel activity; CC: Golgi apparatus, endoplasmic reticulum, membrane, neuronal cell body, nucleoplasm, plasma membrane, sodium channel complex
Pathways: Insulin secretion - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q7TN37
Entrez ID: 68667
|
Does Knockout of 4921536K21Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
4921536K21Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: 4921536K21Rik (RIKEN cDNA 4921536K21 gene)
Type: protein-coding
Summary: Orthologous to human C5orf52 (chromosome 5 open reading frame 52). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9CR34
Entrez ID: 67430
|
Does Knockout of Gtf2e1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Gtf2e1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gtf2e1 (general transcription factor II E, polypeptide 1 (alpha subunit))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q9D0D5
Entrez ID: 74197
|
Does Knockout of Insm1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Insm1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Insm1 (insulinoma-associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adrenal chromaffin cell differentiation, animal organ development, cell differentiation, endocrine pancreas development, endocrine system development, negative regulation of cell population proliferation, negative regulation of protein phosphorylation, negative regulation of transcription by RNA polymerase II, nervous system development, neuron differentiation, noradrenergic neuron development, norepinephrine biosynthetic process, pancreatic A cell differentiation, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of neural precursor cell proliferation, regulation of cell cycle, regulation of cell cycle process, regulation of cell population proliferation, regulation of gene expression, regulation of protein-containing complex assembly, sympathetic ganglion development, system development, tissue development, transdifferentiation, type B pancreatic cell development, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, cyclin binding, histone deacetylase binding, metal ion binding, molecular adaptor activity, protein binding, zinc ion binding; CC: nucleus, transcription repressor complex
Pathways:
UniProt: Q63ZV0
Entrez ID: 53626
|
Does Knockout of Tulp4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Tulp4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tulp4 (TUB like protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9JIL5
Entrez ID: 68842
|
Does Knockout of Osbpl9 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Osbpl9
|
response to bacteria
|
renal medulla cell line
|
Gene: Osbpl9 (oxysterol binding protein-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, sterol binding; CC: Golgi apparatus, cytosol, endosome, late endosome membrane, membrane
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, Synthesis of bile acids and bile salts
UniProt: A2A8Z1
Entrez ID: 100273
|
Does Knockout of Acad11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Acad11
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Acad11 (acyl-Coenzyme A dehydrogenase family, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process, lipid metabolic process; MF: acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA dehydrogenase activity, medium-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion, nucleus, peroxisome
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I
UniProt: Q80XL6
Entrez ID: 102632
|
Does Knockout of Tgfbrap1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Tgfbrap1
|
cell proliferation
|
Regulatory T cell
|
Gene: Tgfbrap1 (transforming growth factor, beta receptor associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, protein transport, regulation of DNA-templated transcription, signal transduction, vesicle-mediated transport; MF: SMAD binding, transforming growth factor beta receptor binding; CC: CORVET complex, cytoplasm, early endosome, endomembrane system, endosome, membrane
Pathways:
UniProt: Q3UR70
Entrez ID: 73122
|
Does Knockout of Banf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Banf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Banf2 (BANF family member 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and identical protein binding activity. Predicted to be involved in chromosome organization. Predicted to be located in cytoplasm. Predicted to be active in condensed chromosome and nucleus. Is expressed in testis. Orthologous to human BANF2 (BANF family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: DNA binding, identical protein binding; CC: condensed chromosome, cytoplasm, nucleus
Pathways:
UniProt: Q8BVR0
Entrez ID: 403171
|
Does Knockout of Ppm1n in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Ppm1n
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ppm1n (protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical Wnt signaling pathway, regulation of canonical NF-kappaB signal transduction; MF: hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytosol, nucleus
Pathways:
UniProt: Q8BGL1
Entrez ID: 232941
|
Does Knockout of Fn3k in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Fn3k
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Fn3k (fructosamine 3 kinase)
Type: protein-coding
Summary: Enables protein-fructosamine 3-kinase activity. Involved in peptidyl-lysine deglycation. Acts upstream of or within fructosamine metabolic process. Is active in cytosol. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: epithelial cell differentiation, fructosamine metabolic process, protein deglycation; MF: ATP binding, kinase activity, nucleotide binding, protein-fructosamine 3-kinase activity, protein-ribulosamine 3-kinase activity, transferase activity; CC: cytosol, mitochondrion
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification
UniProt: Q9ER35
Entrez ID: 63828
|
Does Knockout of Chm in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Chm
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Chm (CHM Rab escort protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, small GTPase-mediated signal transduction, vesicle-mediated transport; MF: GDP-dissociation inhibitor activity, GTPase activator activity, enzyme-substrate adaptor activity, protein-containing complex binding, small GTPase binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: A2AD03, Q3UR39, Q9CS14, Q8CBI2
Entrez ID: 12662
|
Does Knockout of Trip4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Trip4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trip4 (thyroid hormone receptor interactor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen receptor signaling pathway, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of myoblast differentiation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: histone acetyltransferase binding, metal ion binding, nuclear estrogen receptor binding, nuclear receptor binding, protease binding, protein kinase binding, transcription coactivator activity, ubiquitin-like protein ligase binding, zinc ion binding; CC: RQC-trigger complex, centrosome, cytoplasm, cytoskeleton, cytosol, neuromuscular junction, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: Q9QXN3
Entrez ID: 56404
|
Does Knockout of Asic2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Asic2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Asic2 (acid-sensing ion channel 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to acidic pH, cellular response to xenobiotic stimulus, detection of mechanical stimulus involved in sensory perception, establishment of localization in cell, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of apoptotic process, phototransduction, positive regulation of synapse assembly, protein localization to synapse, regulation of membrane potential, regulation of monoatomic ion transmembrane transport, regulation of postsynapse assembly, regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback, regulation of vasoconstriction, response to acidic pH, response to mechanical stimulus, sensory perception of sound, sensory perception of sour taste, sodium ion transmembrane transport, sodium ion transport; MF: ligand-gated sodium channel activity, monoatomic cation channel activity, monoatomic ion channel activity, monoatomic ion-gated channel activity, pH-gated sodium channel activity, protein binding, sodium channel activity; CC: dendritic spine, membrane, neuron projection, neuronal cell body, plasma membrane, postsynaptic density membrane, synapse
Pathways: Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, Taste transduction - Mus musculus (mouse), Transport of small molecules
UniProt: Q925H0
Entrez ID: 11418
|
Does Knockout of Tmco5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tmco5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmco5 (transmembrane and coiled-coil domains 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q9D9D5
Entrez ID: 67356
|
Does Knockout of Luzp1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Luzp1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Luzp1 (leucine zipper protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apical constriction, artery development, contractile ring contraction, negative regulation of cilium assembly, neural fold bending, protein localization to actin cytoskeleton, regulation of protein complex stability, stress fiber assembly, ventricular septum development; MF: actin binding, actin filament binding, microtubule binding, molecular_function, protein binding; CC: CERF complex, actin cytoskeleton, actin filament, anchoring junction, bicellular tight junction, cell projection, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cytoplasm, cytoskeleton, dendrite, microtubule, midbody, nucleus, perikaryon, spindle, spindle midzone, stress fiber, tight junction
Pathways:
UniProt: Q8R4U7
Entrez ID: 269593
|
Does Knockout of Hyal4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Hyal4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Hyal4 (hyaluronoglucosaminidase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, chondroitin sulfate proteoglycan catabolic process, hyaluronan catabolic process; MF: chondroitin hydrolase activity, hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds; CC: cell surface, cytoplasmic vesicle, lysosome, membrane
Pathways: CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q05A56
Entrez ID: 77042
|
Does Knockout of Efcab5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Efcab5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Efcab5 (EF-hand calcium binding domain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: A0JP43
Entrez ID: 319634
|
Does Knockout of Zfp53 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Zfp53
|
cell cycle progression
|
breast epithelium
|
Gene: Zfp53 (zinc finger protein 53)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to several human genes including ZNF320 (zinc finger protein 320); ZNF415 (zinc finger protein 415); and ZNF528 (zinc finger protein 528). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: fibrillar center, microtubule cytoskeleton, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q9Z117
Entrez ID: 24132
|
Does Knockout of Fam234b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Fam234b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Fam234b (family with sequence similarity 234, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cellular_component, cytoplasm, cytoskeleton, membrane, microtubule organizing center
Pathways:
UniProt: Q8BYI8
Entrez ID: 74525
|
Does Knockout of Myadml2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Myadml2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Myadml2 (myeloid-associated differentiation marker-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, membrane
Pathways:
UniProt: Q08AU7
Entrez ID: 68515
|
Does Knockout of Bud31 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,266
|
Knockout
|
Bud31
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Bud31 (BUD31 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription; MF: nuclear receptor binding, transcription coactivator activity; CC: U2-type catalytic step 2 spliceosome, centrosome, chromatin, microtubule cytoskeleton, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q6PGH1
Entrez ID: 231889
|
Does Knockout of Fam186a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Fam186a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam186a (family with sequence similarity 186, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D9R9
Entrez ID: 72277
|
Does Knockout of Matk in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Matk
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Matk (megakaryocyte-associated tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, membrane, plasma membrane
Pathways: Downregulation of ERBB2 signaling, Neurotrophin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases
UniProt: P41242
Entrez ID: 17179
|
Does Knockout of Zfp648 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Zfp648
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp648 (zinc finger protein 648)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: D3Z0W3
Entrez ID: 100503355
|
Does Knockout of Slc35b1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Slc35b1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc35b1 (solute carrier family 35, member B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP transport, ATP transport, UDP-galactose transmembrane transport, UDP-glucose transmembrane transport, transmembrane transport; MF: ATP:ADP antiporter activity, UDP-galactose transmembrane transporter activity, UDP-glucose transmembrane transporter activity, antiporter activity; CC: Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways:
UniProt: P97858
Entrez ID: 110172
|
Does Knockout of Ube2n in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ube2n
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ube2n (ubiquitin-conjugating enzyme E2N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, T cell receptor signaling pathway, TORC1 signaling, antiviral innate immune response, cellular response to nutrient levels, double-strand break repair via homologous recombination, negative regulation of TORC1 signaling, positive regulation of DNA repair, positive regulation of canonical NF-kappaB signal transduction, positive regulation of double-strand break repair, positive regulation of intracellular signal transduction, positive regulation of protein K63-linked ubiquitination, postreplication repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation protein catabolic process at postsynapse, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: UBC13-MMS2 complex, cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynapse, protein-containing complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Aggrephagy, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Autophagy, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Downstream TCR signaling, E3 ubiquitin ligases ubiquitinate target proteins, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, Macroautophagy, Metabolism of proteins, Mitophagy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD1/2 Signaling Pathway, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Selective autophagy, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation
UniProt: P61089
Entrez ID: 93765
|
Does Knockout of Slc5a9 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Slc5a9
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Slc5a9 (solute carrier family 5 (sodium/glucose cotransporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, hexose transmembrane transport, monoatomic ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, carbohydrate:monoatomic cation symporter activity, hexose transmembrane transporter activity, solute:sodium symporter activity, symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q8VDT1
Entrez ID: 230612
|
Does Knockout of Alox12b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Alox12b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type)
Type: protein-coding
Summary: This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: arachidonate metabolic process, bicellular tight junction assembly, ceramide biosynthetic process, establishment of skin barrier, fatty acid metabolic process, hepoxilin biosynthetic process, linoleic acid metabolic process, lipid metabolic process, lipid oxidation, lipoxygenase pathway, positive regulation of MAPK cascade, positive regulation of gene expression, positive regulation of mucus secretion, protein lipidation, sphingolipid metabolic process; MF: arachidonate 12(R)-lipoxygenase activity, arachidonate 12(S)-lipoxygenase activity, arachidonate 8(R)-lipoxygenase activity, dioxygenase activity, iron ion binding, linoleate 9S-lipoxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; CC: cytoplasm, cytosol, membrane, perinuclear region of cytoplasm
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Serotonergic synapse - Mus musculus (mouse), Synthesis of 12-eicosatetraenoic acid derivatives
UniProt: O70582
Entrez ID: 11686
|
Does Knockout of Gm20852 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Gm20852
|
response to bacteria
|
renal medulla cell line
|
Gene: Gm20852 (predicted gene, 20852)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamete generation, regulation of DNA-templated transcription; CC: cytosol, nucleoplasm
Pathways:
UniProt: Q5M8R5
Entrez ID: 100040786
|
Does Knockout of Mtpn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Mtpn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mtpn (myotrophin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of NF-kappaB transcription factor activity, positive regulation of cardiac muscle hypertrophy, positive regulation of cell growth, positive regulation of macromolecule biosynthetic process, positive regulation of protein metabolic process, regulation of barbed-end actin filament capping, regulation of cell size; CC: F-actin capping protein complex, axon, cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: P62774
Entrez ID: 14489
|
Does Knockout of Mctp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Mctp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mctp2 (multiple C2 domains, transmembrane 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, calcium-dependent phospholipid binding, metal ion binding; CC: cytoplasm, cytosol, membrane, nucleoplasm, synaptic vesicle membrane
Pathways:
UniProt: Q5RJH2
Entrez ID: 244049
|
Does Knockout of Zhx1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Zhx1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zhx1 (zinc fingers and homeoboxes 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein heterodimerization activity, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P70121
Entrez ID: 22770
|
Does Knockout of Ankrd49 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Ankrd49
|
cell cycle progression
|
breast epithelium
|
Gene: Ankrd49 (ankyrin repeat domain 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of DNA-templated transcription, spermatogenesis
Pathways:
UniProt: Q8VE42
Entrez ID: 56503
|
Does Knockout of Grb7 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Grb7
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Grb7 (growth factor receptor bound protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of cell migration, signal transduction, stress granule assembly; MF: RNA binding, identical protein binding, lipid binding, phosphatidylinositol binding, protein binding, protein kinase binding; CC: anchoring junction, cell projection, cytoplasm, cytoplasmic stress granule, cytosol, focal adhesion, membrane, plasma membrane
Pathways: Axon guidance, Cell surface interactions at the vascular wall, Developmental Biology, Downstream signal transduction, GRB7 events in ERBB2 signaling, Hemostasis, Nervous system development, RET signaling, RHO GTPase cycle, RND1 GTPase cycle, Signal Transduction, Signaling by ERBB2, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Tie2 Signaling
UniProt: Q03160
Entrez ID: 14786
|
Does Knockout of Trak1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Trak1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trak1 (trafficking protein, kinesin binding 1)
Type: protein-coding
Summary: Enables GABA receptor binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; organelle transport along microtubule; and positive regulation of axonogenesis. Predicted to be located in axonal growth cone; early endosome; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; spleen; and submandibular gland primordium. Used to study Stiff-Person syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axonal transport of mitochondrion, dendrite morphogenesis, endosome to lysosome transport, mitochondrion distribution, neurogenesis, positive regulation of axonogenesis, protein targeting, vesicle transport along microtubule; MF: GABA receptor binding, TPR domain binding, myosin binding; CC: axonal growth cone, cell cortex, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endosome, membrane, mitochondrial membrane, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Miro GTPase Cycle, RHOT1 GTPase cycle, RHOT2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6PD31
Entrez ID: 67095
|
Does Knockout of Gatad2a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,274
|
Knockout
|
Gatad2a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gatad2a (GATA zinc finger domain containing 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior neuropore closure, blood vessel development, chromatin remodeling, embryonic body morphogenesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neural fold formation, positive regulation of DNA-templated transcription, programmed cell death, regulation of cell fate specification, regulation of stem cell differentiation; MF: metal ion binding, protein-macromolecule adaptor activity, zinc ion binding; CC: NuRD complex, chromosome, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by TP53
UniProt: Q8CHY6
Entrez ID: 234366
|
Does Knockout of Gm7854 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Gm7854
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gm7854 (predicted gene 7854)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 665934
|
Does Knockout of Cndp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cndp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cndp1 (carnosine dipeptidase 1)
Type: protein-coding
Summary: Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of protein metabolic process. Located in cytosol. Is expressed in alimentary system; genitourinary system; integumental system; sensory organ; and tail. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis, regulation of protein metabolic process; MF: carboxypeptidase activity, dipeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, peptidase activity; CC: cytosol, extracellular region
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Histidine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q8BUG2
Entrez ID: 338403
|
Does Knockout of Akap7 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Akap7
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Akap7 (A kinase anchor protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, cAMP/PKA signal transduction, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to cAMP, intracellular protein localization, modulation of chemical synaptic transmission, positive regulation of potassium ion transmembrane transport, regulation of membrane repolarization; MF: AMP binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase A binding, protein kinase A regulatory subunit binding, protein kinase binding; CC: T-tubule, apical plasma membrane, cytoplasm, cytosol, exocytic vesicle, hippocampal mossy fiber to CA3 synapse, lateral plasma membrane, nucleus, protein-containing complex, sarcoplasmic reticulum
Pathways:
UniProt: Q7TN79, O55074
Entrez ID: 432442
|
Does Knockout of Tmem132b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Tmem132b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem132b (transmembrane protein 132B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: V9GX71, F7BAB2
Entrez ID: 208151
|
Does Knockout of Abcb6 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Abcb6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Abcb6 (ATP-binding cassette, sub-family B member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular detoxification of cadmium ion, heme metabolic process, heme transmembrane transport, heme transport, intracellular copper ion homeostasis, melanosome assembly, porphyrin-containing compound biosynthetic process, porphyrin-containing compound metabolic process, skin development, tetrapyrrole metabolic process, transmembrane transport; MF: ABC-type heme transporter activity, ABC-type transporter activity, ATP binding, ATP hydrolysis activity, efflux transmembrane transporter activity, heme binding, nucleotide binding, tetrapyrrole binding; CC: Golgi apparatus, Golgi membrane, cytosol, early endosome membrane, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular exosome, extracellular region, late endosome membrane, lysosomal membrane, lysosome, melanosome membrane, membrane, mitochondrial envelope, mitochondrial outer membrane, mitochondrion, multivesicular body membrane, nucleoplasm, plasma membrane, vacuolar membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Mitochondrial ABC transporters, Transport of small molecules
UniProt: Q9DC29
Entrez ID: 74104
|
Does Knockout of Camk2d in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Camk2d
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Camk2d (calcium/calmodulin-dependent protein kinase II, delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, calcium ion transport, cardiac muscle cell contraction, cardiac muscle contraction, cell growth involved in cardiac muscle cell development, endoplasmic reticulum calcium ion homeostasis, establishment of localization in cell, intracellular potassium ion homeostasis, negative regulation of sodium ion transmembrane transport, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of Rac protein signal transduction, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cardiac muscle hypertrophy, positive regulation of smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, protein phosphorylation, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of cardiac muscle cell action potential, regulation of cell communication by electrical coupling, regulation of cellular localization, regulation of membrane depolarization, regulation of neuronal synaptic plasticity, regulation of protein localization to plasma membrane, regulation of relaxation of cardiac muscle, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of sodium ion transport, relaxation of cardiac muscle, response to hypoxia; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, identical protein binding, kinase activity, nitric-oxide synthase binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, sodium channel inhibitor activity, titin binding, transferase activity, transmembrane transporter binding; CC: T-tubule, axon initial segment, calcium- and calmodulin-dependent protein kinase complex, cochlear hair cell ribbon synapse, cytoplasm, intercalated disc, membrane, neuromuscular junction, neuron projection, neuronal cell body, nucleus, organelle, perinuclear region of cytoplasm, plasma membrane, postsynaptic cytosol, postsynaptic density, protein-containing complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Activation of NMDA receptors and postsynaptic events, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytokine Signaling in Immune system, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, GnRH signaling pathway - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Melanogenesis - Mus musculus (mouse), Muscle contraction, Necroptosis - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, Signal Transduction, Trafficking of AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Unblocking of NMDA receptors, glutamate binding and activation, Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q6PHZ2
Entrez ID: 108058
|
Does Knockout of Bhlha9 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Bhlha9
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bhlha9 (basic helix-loop-helix family, member a9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein dimerization activity, protein heterodimerization activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q5RJB0
Entrez ID: 320522
|
Does Knockout of Nptxr in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Nptxr
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nptxr (neuronal pentraxin receptor)
Type: protein-coding
Summary: This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: neuron projection development, neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of postsynaptic specialization assembly; MF: metal ion binding, pentraxin receptor activity, protein phosphatase binding, protein-containing complex binding; CC: extracellular space, glutamatergic synapse, membrane, plasma membrane
Pathways:
UniProt: A0A9R1SP20, Q6PD36
Entrez ID: 73340
|
Does Knockout of Tgoln1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tgoln1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tgoln1 (trans-golgi network protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, endosome, glutamatergic synapse, membrane, nucleoplasm, plasma membrane, postsynaptic Golgi apparatus, trans-Golgi network, trans-Golgi network transport vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q62313
Entrez ID: 22134
|
Does Knockout of Six1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Six1
|
cell proliferation
|
Regulatory T cell
|
Gene: Six1 (sine oculis-related homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, aorta morphogenesis, apoptotic process, branching involved in ureteric bud morphogenesis, cell fate specification, cellular response to 3,3',5-triiodo-L-thyronine, cochlea morphogenesis, embryonic cranial skeleton morphogenesis, embryonic skeletal system morphogenesis, endothelin receptor signaling pathway, epithelial cell differentiation, facial nerve morphogenesis, fungiform papilla morphogenesis, gene expression, generation of neurons, inner ear development, inner ear morphogenesis, kidney development, kidney mesenchyme development, mesenchymal cell differentiation, mesenchymal cell proliferation, mesonephric tubule formation, metanephric mesenchyme development, metanephros development, middle ear morphogenesis, myoblast migration, myotome development, negative regulation of apoptotic process, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, nephron epithelium morphogenesis, neural crest cell differentiation, neurogenesis, neuron fate specification, olfactory placode formation, organ induction, otic vesicle development, outflow tract morphogenesis, pattern specification process, pharyngeal system development, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of brown fat cell differentiation, positive regulation of mesenchymal cell proliferation involved in ureter development, positive regulation of myoblast proliferation, positive regulation of secondary heart field cardioblast proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of ureteric bud formation, protein localization to nucleus, regulation of DNA-templated transcription, regulation of branch elongation involved in ureteric bud branching, regulation of branching involved in ureteric bud morphogenesis, regulation of epithelial cell proliferation, regulation of gene expression, regulation of neuron differentiation, regulation of protein localization, regulation of skeletal muscle cell differentiation, regulation of skeletal muscle cell proliferation, regulation of skeletal muscle satellite cell proliferation, regulation of synaptic assembly at neuromuscular junction, regulation of transcription by RNA polymerase II, sensory perception of sound, skeletal muscle fiber development, skeletal muscle tissue development, skeletal system morphogenesis, specification of segmental identity, maxillary segment, thymus development, thyroid gland development, tongue development, trigeminal ganglion development, ureter smooth muscle cell differentiation, ureteric bud development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q62231
Entrez ID: 20471
|
Does Knockout of Rassf2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rassf2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rassf2 (Ras association (RalGDS/AF-6) domain family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone remodeling, canonical NF-kappaB signal transduction, epidermal growth factor receptor signaling pathway, homeostasis of number of cells, negative regulation of non-canonical NF-kappaB signal transduction, ossification, positive regulation of JNK cascade, positive regulation of apoptotic process, protein stabilization, regulation of non-canonical NF-kappaB signal transduction, regulation of osteoblast differentiation, regulation of osteoclast differentiation, signal transduction, skeletal system development; MF: protein binding, protein kinase activity; CC: Golgi apparatus, chromosome, chromosome, centromeric region, cytoplasm, cytosol, kinetochore, nucleoplasm, nucleus, plasma membrane, protein-containing complex
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q8BMS9
Entrez ID: 215653
|
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