prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Zhx3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Zhx3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zhx3 (zinc fingers and homeoboxes 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of osteoblast differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, zinc ion binding; CC: cell cortex, nucleoplasm, nucleus
Pathways:
UniProt: Q8C0Q2
Entrez ID: 320799
|
Does Knockout of Oosp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Oosp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Oosp1 (oocyte secreted protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, in utero embryonic development; CC: extracellular region
Pathways:
UniProt: Q925U0
Entrez ID: 170834
|
Does Knockout of Fbxw22 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Fbxw22
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxw22 (F-box and WD-40 domain protein 22)
Type: protein-coding
Summary: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: Q3TSG7, Q5XG67, A0A0G2JEJ2
Entrez ID: 382156
|
Does Knockout of Rab8a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Rab8a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rab8a (RAB8A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Golgi vesicle fusion to target membrane, autophagy, axonogenesis, cell projection organization, cellular response to insulin stimulus, cilium assembly, endocytic recycling, exocytosis, neurotransmitter receptor transport to postsynaptic membrane, neurotransmitter receptor transport, endosome to postsynaptic membrane, protein localization to cilium, protein localization to plasma membrane, protein transport, regulation of autophagy, regulation of long-term neuronal synaptic plasticity, regulation of protein localization, regulation of protein transport, vesicle docking involved in exocytosis, vesicle-mediated transport in synapse; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, myosin V binding, nucleotide binding, protein binding, protein kinase binding, protein tyrosine kinase binding, small GTPase binding; CC: Golgi apparatus, actin cytoskeleton, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary base, ciliary membrane, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, dendrite, endomembrane system, endosome, endosome membrane, glutamatergic synapse, lysosome, membrane, midbody, neuron projection, neuronal cell body, non-motile cilium, nucleolus, nucleoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, synapse, synaptic vesicle, trans-Golgi network transport vesicle
Pathways: AMPK signaling pathway - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Autophagy - animal - Mus musculus (mouse), Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cilium Assembly, Endocytosis - Mus musculus (mouse), G2/M Transition, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Organelle biogenesis and maintenance, Pancreatic secretion - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Regulation of PLK1 Activity at G2/M Transition, TBC/RABGAPs, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: P55258
Entrez ID: 17274
|
Does Knockout of Cenpc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Cenpc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cenpc1 (centromere protein C1)
Type: protein-coding
Summary: This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, mitotic cell cycle, spindle attachment to meiosis I kinetochore; MF: DNA binding, centromeric DNA binding, identical protein binding, protein binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, inner kinetochore, kinetochore, midbody, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P49452
Entrez ID: 12617
|
Does Knockout of Ubr5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Ubr5
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, estrogen receptor signaling pathway, heterochromatin boundary formation, negative regulation of interleukin-17 production, negative regulation of smoothened signaling pathway, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of protein import into nucleus, progesterone receptor signaling pathway, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein polyubiquitination, protein ubiquitination, regulation of protein stability, response to oxidative stress, retinoic acid receptor signaling pathway, ubiquitin-dependent protein catabolic process via the N-end rule pathway, vitamin D receptor signaling pathway; MF: RNA binding, metal ion binding, protein binding, protein domain specific binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q80TP3
Entrez ID: 70790
|
Does Knockout of Tigar in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Tigar
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tigar (Trp53 induced glycolysis regulatory phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, apoptotic process, autophagy, cellular response to cobalt ion, cellular response to hypoxia, fructose 2,6-bisphosphate metabolic process, intestinal epithelial cell development, negative regulation of glucose catabolic process to lactate via pyruvate, negative regulation of glycolytic process, negative regulation of mitophagy, negative regulation of programmed cell death, negative regulation of reactive oxygen species metabolic process, positive regulation of DNA repair, positive regulation of cardiac muscle cell apoptotic process, positive regulation of hexokinase activity, positive regulation of nucleobase-containing compound metabolic process, positive regulation of pentose-phosphate shunt, positive regulation of phosphate metabolic process, regulation of pentose-phosphate shunt, regulation of programmed cell death, regulation of response to DNA damage checkpoint signaling, response to gamma radiation, response to ischemia, response to stress, response to xenobiotic stimulus; MF: catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity; CC: cytoplasm, cytosol, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53
UniProt: Q8BZA9
Entrez ID: 319801
|
Does Knockout of Hook1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Hook1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hook1 (hook microtubule tethering protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cell differentiation, cytoplasmic microtubule organization, cytoskeleton-dependent intracellular transport, early endosome to late endosome transport, endomembrane system organization, endosome organization, endosome to lysosome transport, lysosome organization, manchette assembly, protein localization to perinuclear region of cytoplasm, protein transport, spermatid development, spermatogenesis; MF: actin binding, dynein light intermediate chain binding, identical protein binding, microtubule binding, protein binding, protein homodimerization activity; CC: FHF complex, HOPS complex, centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways:
UniProt: Q8BIL5
Entrez ID: 77963
|
Does Knockout of Wfdc3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Wfdc3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Wfdc3 (WAP four-disulfide core domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q14AE4
Entrez ID: 71856
|
Does Knockout of Tbx22 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Tbx22
|
response to virus
|
Microglial Cell Line
|
Gene: Tbx22 (T-box 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell fate specification, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription repressor complex, chromatin, nucleus
Pathways:
UniProt: Q8K402
Entrez ID: 245572
|
Does Knockout of Slc18a3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Slc18a3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc18a3 (solute carrier family 18 (vesicular monoamine), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine transport, acetylcholine uptake, chemical synaptic transmission, monoamine transport, neurotransmitter loading into synaptic vesicle, neurotransmitter transport, positive regulation of acetylcholine secretion, neurotransmission, positive regulation of long-term synaptic potentiation, positive regulation of neuromuscular junction development, proton transmembrane transport, serotonin uptake, transmembrane transport; MF: acetylcholine transmembrane transporter activity, acetylcholine:proton antiporter activity, active transmembrane transporter activity, monoamine transmembrane transporter activity, monoamine:proton antiporter activity, protein binding, transmembrane transporter activity; CC: AP-1 adaptor complex, AP-2 adaptor complex, axon, axon terminus, cholinergic synapse, cytoplasm, cytoplasmic vesicle, membrane, neuromuscular junction, neuron projection, synapse, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways: Cholinergic synapse - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q3TYJ1
Entrez ID: 20508
|
Does Knockout of Exoc5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Exoc5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Exoc5 (exocyst complex component 5)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Involved in protein localization to plasma membrane. Acts upstream of or within with a positive effect on establishment of planar polarity. Acts upstream of or within with a negative effect on epithelial cell apoptotic process. Acts upstream of or within homeostasis of number of cells within a tissue; morphogenesis of a polarized epithelium; and non-motile cilium assembly. Predicted to be located in cytosol. Predicted to be part of exocyst. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; cortical plate; primary oocyte; and secondary oocyte. Used to study obstructive nephropathy. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi to plasma membrane transport, epithelial cell apoptotic process, establishment of planar polarity, exocytosis, homeostasis of number of cells within a tissue, membrane fission, mitotic cytokinesis, morphogenesis of a polarized epithelium, non-motile cilium assembly, protein localization to plasma membrane, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, exocyst, midbody
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Salmonella infection - Mus musculus (mouse), VxPx cargo-targeting to cilium
UniProt: Q3TPX4
Entrez ID: 105504
|
Does Knockout of Ly6c1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Ly6c1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ly6c1 (lymphocyte antigen 6 family member C1)
Type: protein-coding
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system; liver; metanephros; midgut; and nasal cavity. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: acetylcholine receptor binding, acetylcholine receptor inhibitor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, side of membrane, synapse
Pathways:
UniProt: P0CW02
Entrez ID: 17067
|
Does Knockout of Gm5111 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Gm5111
|
cell cycle progression
|
breast epithelium
|
Gene: Gm5111 (predicted gene 5111)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3SXC8, Q8C9M4
Entrez ID: 330305
|
Does Knockout of Slk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Slk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slk (STE20-like kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to type II interferon, cytoplasmic microtubule organization, intracellular signal transduction, positive regulation of apoptotic process, protein autophosphorylation, regulation of apoptotic process, regulation of cell migration, regulation of focal adhesion assembly; MF: ATP binding, histone kinase activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell leading edge, cytoplasm, perinuclear region of cytoplasm
Pathways: Oocyte meiosis - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O54988
Entrez ID: 20874
|
Does Knockout of Gm44140 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gm44140
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gm44140 (predicted gene, 44140)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 108169174
|
Does Knockout of Sphkap in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Sphkap
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sphkap (SPHK1 interactor, AKAP domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein kinase A binding; CC: Z disc, cytoplasm, mitochondrion
Pathways:
UniProt: A0A0R4J1Y6, E9PUC4
Entrez ID: 77629
|
Does Knockout of Usp2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Usp2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Usp2 (ubiquitin specific peptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian behavior, circadian regulation of gene expression, entrainment of circadian clock by photoperiod, locomotor rhythm, muscle organ development, negative regulation of calcium ion transport, negative regulation of skeletal muscle tissue development, negative regulation of transcription by RNA polymerase II, positive regulation of mitotic cell cycle, positive regulation of skeletal muscle tissue development, protein deubiquitination, protein stabilization, proteolysis, rhythmic process; MF: cyclin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, identical protein binding, metal ion binding, peptidase activity, protein binding, ubiquitin protein ligase binding; CC: cell cortex, centrosome, cytoplasm, membrane, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: O88623
Entrez ID: 53376
|
Does Knockout of Rps19 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rps19
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rps19 (ribosomal protein S19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-negative bacterium, erythrocyte differentiation, killing of cells of another organism, maturation of SSU-rRNA, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), monocyte chemotaxis, negative regulation of respiratory burst involved in inflammatory response, nucleolus organization, positive regulation of respiratory burst involved in inflammatory response, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation; MF: RNA binding, fibroblast growth factor binding, identical protein binding, protein kinase binding, structural constituent of ribosome, translation initiation factor binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleoplasm, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CZX8
Entrez ID: 20085
|
Does Knockout of Pwwp2b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Pwwp2b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pwwp2b (PWWP domain containing 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, regulation of cold-induced thermogenesis; MF: NuRD complex binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: E9Q9M8
Entrez ID: 101631
|
Does Knockout of Shd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Shd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Shd (src homology 2 domain-containing transforming protein D)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: O88834
Entrez ID: 20420
|
Does Knockout of Cacng5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Cacng5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cacng5 (calcium channel, voltage-dependent, gamma subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter receptor diffusion trapping, regulation of AMPA receptor activity, transmission of nerve impulse; MF: channel regulator activity, voltage-gated calcium channel activity; CC: AMPA glutamate receptor complex, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: Q8VHW4
Entrez ID: 140723
|
Does Knockout of Plekha2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Plekha2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Plekha2 (pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell-matrix adhesion; MF: PDZ domain binding, fibronectin binding, laminin binding, lipid binding, phosphatidylinositol-3,4-bisphosphate binding, phospholipid binding, protein binding; CC: cytoplasm, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q9ERS5
Entrez ID: 83436
|
Does Knockout of Actn2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Actn2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Actn2 (actinin alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament uncapping, cardiac muscle cell development, focal adhesion assembly, microspike assembly, muscle cell development, muscle contraction, negative regulation of potassium ion transport, negative regulation of protein localization to cell surface, phospholipase C-activating angiotensin-activated signaling pathway, positive regulation of DNA-templated transcription, positive regulation of endocytic recycling, positive regulation of potassium ion transport, postsynaptic actin cytoskeleton organization, protein localization to plasma membrane, regulation of membrane potential, sarcomere organization; MF: FATZ binding, LIM domain binding, actin binding, actin filament binding, calcium ion binding, channel activator activity, cytoskeletal protein binding, identical protein binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, structural constituent of postsynaptic actin cytoskeleton, titin Z domain binding, titin binding, transcription coactivator activity, transmembrane transporter binding; CC: Z disc, actin cytoskeleton, cell junction, cell projection, cortical actin cytoskeleton, cytoplasm, filopodium, focal adhesion, glutamatergic synapse, plasma membrane, postsynaptic actin cytoskeleton, postsynaptic density membrane, postsynaptic density, intracellular component, sarcomere, striated muscle thin filament
Pathways: Activation of NMDA receptors and postsynaptic events, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Hemostasis, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Muscle contraction, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Platelet activation, signaling and aggregation, Platelet degranulation , RAF/MAP kinase cascade, Response to elevated platelet cytosolic Ca2+, Signal Transduction, Striated Muscle Contraction, Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation
UniProt: Q9JI91
Entrez ID: 11472
|
Does Knockout of Scgb1b24 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Scgb1b24
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Scgb1b24 (secretoglobin, family 1B, member 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, steroid binding; CC: extracellular region
Pathways:
UniProt: B1B0N6
Entrez ID: 100043860
|
Does Knockout of Csnk1e in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Csnk1e
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Csnk1e (casein kinase 1, epsilon)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, cellular response to nerve growth factor stimulus, circadian behavior, circadian regulation of gene expression, circadian rhythm, endocytosis, intracellular protein localization, negative regulation of Wnt signaling pathway, negative regulation of small GTPase mediated signal transduction, non-canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of amyloid-beta formation, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein phosphorylation, regulation of circadian rhythm, regulation of protein localization, rhythmic process, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, growth cone, neuronal cell body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: AURKA Activation by TPX2, Alzheimer disease - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, Circadian rhythm - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1/S DNA Damage Checkpoints, G2/M Transition, Hedgehog signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, WNT mediated activation of DVL, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9JMK2
Entrez ID: 27373
|
Does Knockout of Cd83 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Cd83
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cd83 (CD83 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of interleukin-4 production, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of interleukin-10 production, positive regulation of interleukin-2 production; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: O88324
Entrez ID: 12522
|
Does Knockout of Kctd16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Kctd16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kctd16 (potassium channel tetramerisation domain containing 16)
Type: protein-coding
Summary: Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within behavioral fear response; memory; and regulation of G protein-coupled receptor signaling pathway. Located in postsynaptic membrane and presynaptic membrane. Part of receptor complex. Is expressed in autopod; central nervous system; dorsal root ganglion; sensory organ; and trachea. Orthologous to human KCTD16 (potassium channel tetramerization domain containing 16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: behavioral fear response, memory, protein homooligomerization, regulation of G protein-coupled receptor signaling pathway, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential; MF: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential, G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential, molecular_function; CC: cell projection, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, receptor complex, synapse
Pathways:
UniProt: Q5DTY9
Entrez ID: 383348
|
Does Knockout of Amigo3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Amigo3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Amigo3 (adhesion molecule with Ig like domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, negative regulation of neuron projection development, nervous system development, positive regulation of synapse assembly; MF: molecular_function, protein-containing complex binding; CC: membrane
Pathways:
UniProt: Q8C2S7
Entrez ID: 320844
|
Does Knockout of Zfp474 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Zfp474
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp474 (zinc finger protein 474)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6V5K9
Entrez ID: 66758
|
Does Knockout of Gsta3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Gsta3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Gsta3 (glutathione S-transferase, alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aflatoxin catabolic process, glutathione metabolic process, lipid metabolic process, ureteric bud development, xenobiotic metabolic process; MF: dinitrosyl-iron complex binding, fatty acid binding, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, steroid Delta-isomerase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Azathioprine ADME, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Heme degradation, Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of porphyrins, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P30115
Entrez ID: 14859
|
Does Knockout of Dcdc2b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Dcdc2b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dcdc2b (doublecortin domain containing 2b)
Type: protein-coding
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: biological_process, intracellular signal transduction; CC: microtubule, microtubule organizing center
Pathways:
UniProt: F7BCK0, J3KML0
Entrez ID: 100504491
|
Does Knockout of Barx1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Barx1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Barx1 (BarH-like homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, anterior/posterior pattern specification, cell-cell signaling, digestive system development, endothelial cell differentiation, negative regulation of Wnt signaling pathway, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spleen development, tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q9ER42
Entrez ID: 12022
|
Does Knockout of Cep135 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Cep135
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cep135 (centrosomal protein 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, centriole-centriole cohesion, positive regulation of establishment of protein localization, positive regulation of non-motile cilium assembly; MF: identical protein binding, microtubule binding, protein homodimerization activity, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q6P5D4
Entrez ID: 381644
|
Does Knockout of Fam169a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Fam169a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Fam169a (family with sequence similarity 169, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways: RHO GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q5XG69
Entrez ID: 320557
|
Does Knockout of Papss1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Papss1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Papss1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1)
Type: protein-coding
Summary: Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Predicted to be part of sulfate adenylyltransferase complex (ATP). Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process, sulfate assimilation; MF: ATP binding, adenylylsulfate kinase activity, catalytic activity, kinase activity, nucleotide binding, nucleotidyltransferase activity, protein homodimerization activity, sulfate adenylyltransferase (ATP) activity, transferase activity; CC: cytoplasm, cytosol, nucleus, sulfate adenylyltransferase complex (ATP)
Pathways: Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Purine metabolism - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse), Sulfur metabolism - Mus musculus (mouse), Transport and metabolism of PAPS, sulfate activation for sulfonation, sulfur metabolism
UniProt: Q60967
Entrez ID: 23971
|
Does Knockout of Eif2s1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Eif2s1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: HRI-mediated signaling, PERK-mediated unfolded protein response, cellular response to UV, cellular response to amino acid starvation, cellular response to chemical stress, cellular response to heat, cellular response to oxidative stress, mitochondrial respirasome assembly, mitophagy, negative regulation of translational initiation in response to stress, positive regulation of type B pancreatic cell apoptotic process, regulation of translation, regulation of translation in response to endoplasmic reticulum stress, regulation of translational initiation in response to stress, response to endoplasmic reticulum stress, response to kainic acid, response to manganese-induced endoplasmic reticulum stress, stress granule assembly, translation, translational initiation; MF: RNA binding, nucleic acid binding, protein binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 2 complex, glial limiting end-foot, mitochondrion, nucleus, synapse, translation initiation ternary complex
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Non-alcoholic fatty liver disease - Mus musculus (mouse), PERK regulates gene expression, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q6ZWX6
Entrez ID: 13665
|
Does Knockout of Arhgap30 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Arhgap30
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Arhgap30 (Rho GTPase activating protein 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of Rho protein signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOU GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q640N3
Entrez ID: 226652
|
Does Knockout of Tbc1d9 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Tbc1d9
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Tbc1d9 (TBC1 domain family, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTPase activator activity, calcium ion binding
Pathways:
UniProt: Q3UYK3
Entrez ID: 71310
|
Does Knockout of Ripply3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ripply3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ripply3 (ripply transcriptional repressor 3)
Type: protein-coding
Summary: Involved in heart development; negative regulation of transcription by RNA polymerase II; and pharyngeal system development. Acts upstream of or within negative regulation of cell population proliferation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human RIPPLY3 (ripply transcriptional repressor 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: embryonic pattern specification, heart development, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, pharyngeal system development; CC: nucleus
Pathways:
UniProt: Q924S9
Entrez ID: 170765
|
Does Knockout of Slc4a11 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Slc4a11
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Slc4a11 (solute carrier family 4, sodium bicarbonate transporter-like, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, borate transmembrane transport, borate transport, cellular hypotonic response, cellular response to oxidative stress, fluid transport, intracellular monoatomic cation homeostasis, monoatomic anion transport, monoatomic ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of mesenchymal stem cell differentiation, regulation of mitochondrial membrane potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport, water transport; MF: active borate transmembrane transporter activity, antiporter activity, bicarbonate transmembrane transporter activity, protein dimerization activity, proton channel activity, proton transmembrane transporter activity, sodium channel activity, solute:inorganic anion antiporter activity, symporter activity, transmembrane transporter activity, water transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane, vesicle membrane
Pathways:
UniProt: A2AJN7
Entrez ID: 269356
|
Does Knockout of Ypel4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ypel4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ypel4 (yippee like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of erythrocyte clearance, negative regulation of erythrocyte differentiation, protein localization to plasma membrane, regulation of cell shape; MF: metal ion binding, protein binding; CC: cellular_component, nucleolus, nucleus
Pathways:
UniProt: Q65Z93
Entrez ID: 241525
|
Does Knockout of Snx4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Snx4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Snx4 (sorting nexin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, positive regulation of autophagosome assembly, positive regulation of histamine secretion by mast cell, protein transport; MF: epidermal growth factor receptor binding, insulin receptor binding, leptin receptor binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, transferrin receptor binding; CC: SNARE complex, cytoplasm, cytoplasmic dynein complex, early endosome, early endosome membrane, endosome, membrane, plasma membrane, presynaptic endosome, protein-containing complex
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q91YJ2
Entrez ID: 69150
|
Does Knockout of Btk in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Btk
|
phagocytosis
|
macrophage
|
Gene: Btk (Bruton agammaglobulinemia tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell affinity maturation, B cell receptor signaling pathway, T cell receptor signaling pathway, adaptive immune response, apoptotic process, cGAS/STING signaling pathway, cell maturation, cellular response to interleukin-7, cellular response to molecule of fungal origin, cellular response to reactive oxygen species, eosinophil homeostasis, histamine secretion by mast cell, immune system process, innate immune response, intracellular signal transduction, monocyte proliferation, negative regulation of B cell activation, negative regulation of B cell proliferation, negative regulation of cytokine production, negative regulation of interleukin-10 production, negative regulation of leukocyte proliferation, neutrophil homeostasis, positive regulation of B cell proliferation, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of cGAS/STING signaling pathway, positive regulation of immunoglobulin production, positive regulation of interleukin-17A production, positive regulation of interleukin-6 production, positive regulation of phagocytosis, positive regulation of synoviocyte proliferation, positive regulation of tumor necrosis factor production, positive regulation of type I hypersensitivity, positive regulation of type I interferon production, positive regulation of type III hypersensitivity, proteoglycan catabolic process, regulation of B cell activation, response to lipopolysaccharide; MF: ATP binding, identical protein binding, kinase activity, lipid binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phospholipase activator activity, phospholipase binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, membrane, membrane raft, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), DAP12 interactions, DAP12 signaling, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated Ca+2 mobilization, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fcgamma receptor (FCGR) dependent phagocytosis, G alpha (12/13) signalling events, G alpha (q) signalling events, G beta:gamma signalling through BTK, G-protein beta:gamma signalling, GPCR downstream signalling, Immune System, Innate Immune System, NF-kappa B signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by the B Cell Receptor (BCR)
UniProt: P35991
Entrez ID: 12229
|
Does Knockout of Zp1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Zp1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Zp1 (zona pellucida glycoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, prevention of polyspermy, single fertilization; MF: acrosin binding, structural constituent of egg coat; CC: egg coat, extracellular matrix, extracellular region, membrane, plasma membrane
Pathways: Fertilization, Interaction With Cumulus Cells And The Zona Pellucida, Reproduction
UniProt: Q62005
Entrez ID: 22786
|
Does Knockout of Prr5l in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Prr5l
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Prr5l (proline rich 5 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, cellular response to oxidative stress, negative regulation of protein phosphorylation, negative regulation of signal transduction, positive regulation of intracellular protein transport, positive regulation of mRNA catabolic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of fibroblast migration; MF: ubiquitin protein ligase binding; CC: TORC2 complex, mitochondrion
Pathways:
UniProt: A2AVJ5
Entrez ID: 72446
|
Does Knockout of Clcn4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Clcn4
|
cell cycle progression
|
breast epithelium
|
Gene: Clcn4 (chloride channel, voltage-sensitive 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, monoatomic ion transport, non-motile cilium assembly, transmembrane transport; MF: ATP binding, antiporter activity, chloride channel activity, chloride transmembrane transporter activity, nucleotide binding, voltage-gated chloride channel activity; CC: Golgi apparatus, ciliary base, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane, synaptic vesicle
Pathways: Ion channel transport, Neutrophil extracellular trap formation - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: Q61418
Entrez ID: 12727
|
Does Knockout of Cfap73 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Cfap73
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cfap73 (cilia and flagella associated protein 73)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cilium movement, inner dynein arm assembly; MF: dynein complex binding, molecular_function; CC: axonemal doublet microtubule, cell projection, cellular_component, cilium, cytoplasm, cytoskeleton, motile cilium
Pathways:
UniProt: J3QPZ5
Entrez ID: 546886
|
Does Knockout of Arhgef12 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Arhgef12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, regulation of blood pressure; MF: G protein-coupled receptor binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), NRAGE signals death through JNK, Nervous system development, Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tuberculosis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cyclic AMP biosynthesis, p75 NTR receptor-mediated signalling
UniProt: Q8R4H2
Entrez ID: 69632
|
Does Knockout of Atp13a1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Atp13a1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Atp13a1 (ATPase type 13A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extraction of mislocalized protein from ER membrane, intracellular calcium ion homeostasis, monoatomic cation transmembrane transport, protein transport, transmembrane transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, membrane protein dislocase activity, metal ion binding, nucleotide binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q9EPE9
Entrez ID: 170759
|
Does Knockout of Gosr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gosr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gosr2 (golgi SNAP receptor complex member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, protein transport, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, late endosome membrane, membrane, nucleoplasm
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35166
Entrez ID: 56494
|
Does Knockout of Sgpp2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Sgpp2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Sgpp2 (sphingosine-1-phosphate phosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phospholipid dephosphorylation, regulation of type B pancreatic cell proliferation, sphingosine metabolic process; MF: dihydrosphingosine-1-phosphate phosphatase activity, hydrolase activity, sphingosine-1-phosphate phosphatase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse)
UniProt: Q810K3
Entrez ID: 433323
|
Does Knockout of Yme1l1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Yme1l1
|
cell cycle progression
|
breast epithelium
|
Gene: Yme1l1 (YME1-like 1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, cellular response to starvation, mitochondrial protein catabolic process, mitochondrial protein processing, mitochondrion organization, negative regulation of apoptotic process, neuronal stem cell population maintenance, positive regulation of mitochondrial fusion, protein hexamerization, protein quality control for misfolded or incompletely synthesized proteins, proteolysis, regulation of stem cell division; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleotide binding, peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nuclear body
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: O88967
Entrez ID: 27377
|
Does Knockout of Ptms in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ptms
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ptms (parathymosin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II; MF: histone binding, zinc ion binding
Pathways:
UniProt: Q9D0J8
Entrez ID: 69202
|
Does Knockout of Dsc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Dsc1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dsc1 (desmocollin 1)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epidermal fragility together with defects of epidermal barrier and differentiation. The neonatal mice lacking the encoded protein exhibit epidermal lesions and older mice develop chronic dermatitis. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, desmosome maintenance, establishment of skin barrier, hair follicle morphogenesis, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of epithelial cell proliferation; MF: calcium ion binding, protein binding; CC: anchoring junction, desmosome, membrane, plasma membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Immune System, Innate Immune System, Keratinization, Neutrophil degranulation
UniProt: P55849
Entrez ID: 13505
|
Does Knockout of Sfswap in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Sfswap
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Sfswap (splicing factor SWAP)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, alternative mRNA splicing, via spliceosome, mRNA 5'-splice site recognition, mRNA processing, negative regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding
Pathways:
UniProt: Q3USH5
Entrez ID: 231769
|
Does Knockout of Pon1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Pon1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pon1 (paraoxonase 1)
Type: protein-coding
Summary: Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: blood circulation, carboxylic acid catabolic process, cholesterol metabolic process, lactone catabolic process, organophosphate catabolic process, phosphatidylcholine metabolic process, positive regulation of cholesterol efflux, response to fluoride, response to toxic substance; MF: acyl-L-homoserine-lactone lactonohydrolase activity, aryldialkylphosphatase activity, arylesterase activity, calcium ion binding, high-density lipoprotein particle binding, hydrolase activity, metal ion binding, phospholipid binding, protein homodimerization activity; CC: extracellular region, extracellular space, high-density lipoprotein particle, spherical high-density lipoprotein particle
Pathways: Arachidonate metabolism, Atorvastatin ADME, Drug ADME, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids, methyl parathion degradation, paraoxon degradation, parathion degradation
UniProt: P52430
Entrez ID: 18979
|
Does Knockout of Mbp in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Mbp
|
response to virus
|
Microglial Cell Line
|
Gene: Mbp (myelin basic protein)
Type: protein-coding
Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, maintenance of blood-brain barrier, membrane organization, myelination, negative regulation of axonogenesis, negative regulation of heterotypic cell-cell adhesion, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-6 production, response to progesterone, response to toxic substance, sensory perception of sound; MF: calmodulin binding, lipid binding, protease binding, structural constituent of myelin sheath; CC: cell periphery, cell projection, cell surface, compact myelin, cytoplasm, internode region of axon, membrane, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex
Pathways:
UniProt: P04370
Entrez ID: 17196
|
Does Knockout of Zfp839 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Zfp839
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp839 (zinc finger protein 839)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9CSB3, E9PUU5, B2RWW3, A0A1Y7VNF0, A0A1Y7VL21
Entrez ID: 72805
|
Does Knockout of Pomt1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Pomt1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pomt1 (protein-O-mannosyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation; MF: dolichyl-phosphate-mannose-protein mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: acrosomal vesicle, dolichyl-phosphate-mannose-protein mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, sarcoplasmic reticulum
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, DAG1 core M1 glycosylations, DAG1 core M2 glycosylations, DAG1 core M3 glycosylations, DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism of proteins, O-linked glycosylation, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8R2R1
Entrez ID: 99011
|
Does Knockout of Il15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Il15
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Il15 (interleukin 15)
Type: protein-coding
Summary: This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: NK T cell proliferation, cell maturation, extrathymic T cell selection, hyaluronan metabolic process, immune response, interleukin-15-mediated signaling pathway, lymph node development, macrophage differentiation, negative regulation of cold-induced thermogenesis, negative regulation of smooth muscle cell proliferation, neutrophil activation, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of immune response, positive regulation of interleukin-17 production, positive regulation of natural killer cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of phagocytosis, regulation of T cell differentiation, regulation of defense response to virus by host; MF: cytokine activity, cytokine receptor binding; CC: cell surface, cytoplasm, cytosol, extracellular region, extracellular space, nuclear speck, nucleoplasm
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Interleukin-15 signaling, Interleukin-2 family signaling, Intestinal immune network for IgA production - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signaling by Interleukins, TNF signaling pathway - Mus musculus (mouse)
UniProt: P48346
Entrez ID: 16168
|
Does Knockout of Evx2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Evx2
|
phagocytosis
|
macrophage
|
Gene: Evx2 (even-skipped homeobox 2)
Type: protein-coding
Summary: This gene is located at the 5' end of the Hoxd gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. The encoded protein plays a role in limb morphogenesis. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: limb morphogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: P49749
Entrez ID: 14029
|
Does Knockout of Susd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Susd2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Susd2 (sushi domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell cycle G1/S phase transition, negative regulation of cell division; CC: extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9DBX3
Entrez ID: 71733
|
Does Knockout of Slco1c1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Slco1c1
|
phagocytosis
|
macrophage
|
Gene: Slco1c1 (solute carrier organic anion transporter family, member 1c1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, positive regulation of thyroid hormone generation, sodium-independent organic anion transport, thyroid hormone transport, transmembrane transport; MF: bile acid transmembrane transporter activity, organic anion transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Thyroid hormone signaling pathway - Mus musculus (mouse), Transport of small molecules
UniProt: Q9ERB5
Entrez ID: 58807
|
Does Knockout of Rprm in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rprm
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rprm (reprimo, TP53 dependent G2 arrest mediator candidate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cell cycle, regulation of mitotic cell cycle; CC: cytoplasm, membrane
Pathways: p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9JJ72
Entrez ID: 67874
|
Does Knockout of Gzmg in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gzmg
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gzmg (granzyme G)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including early conceptus and female reproductive system. Orthologous to human GZMB (granzyme B) and GZMH (granzyme H). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: killing of cells of another organism, protein maturation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytoplasm, extracellular space, lysosome
Pathways:
UniProt: P13366
Entrez ID: 14944
|
Does Knockout of Daam1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Daam1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Daam1 (dishevelled associated activator of morphogenesis 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, actin cytoskeleton organization, presynaptic actin cytoskeleton organization; MF: actin binding, identical protein binding, protein binding, small GTPase binding; CC: cell projection, ciliary basal body, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, motile cilium, perinuclear region of cytoplasm, plasma membrane, presynapse, stress fiber, synapse
Pathways: Beta-catenin independent WNT signaling, PCP/CE pathway, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q8BPM0
Entrez ID: 208846
|
Does Knockout of Klra4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Klra4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Klra4 (killer cell lectin-like receptor, subfamily A, member 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: carbohydrate binding, protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Malaria - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q60651
Entrez ID: 16635
|
Does Knockout of Ddx47 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Ddx47
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Ddx47 (DEAD box helicase 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CWX9
Entrez ID: 67755
|
Does Knockout of Pxdn in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pxdn
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pxdn (peroxidasin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, basement membrane assembly, basement membrane organization, cell adhesion, cellular oxidant detoxification, collagen fibril organization, extracellular matrix organization, eye development, hydrogen peroxide catabolic process, protein homooligomerization, protein homotrimerization, response to oxidative stress, system development; MF: extracellular matrix structural constituent, heme binding, lactoperoxidase activity, laminin-1 binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on peroxide as acceptor, peroxidase activity; CC: basement membrane, cell surface, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, Extracellular matrix organization, phosphate acquisition II
UniProt: Q3UQ28
Entrez ID: 69675
|
Does Knockout of Fto in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,545
|
Knockout
|
Fto
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fto (FTO alpha-ketoglutarate dependent dioxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA alkylation repair, RNA repair, adipose tissue development, mRNA destabilization, negative regulation of eating behavior, osteoblast differentiation, positive regulation of apoptotic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of brown fat cell differentiation, regulation of cytosolic calcium ion concentration, regulation of lipid storage, regulation of multicellular organism growth, regulation of respiratory system process, regulation of white fat cell proliferation, sensory perception of pain, snRNA processing, temperature homeostasis; MF: 2-oxoglutarate-dependent dioxygenase activity, broad specificity oxidative DNA demethylase activity, dioxygenase activity, ferrous iron binding, mRNA N6-methyladenosine dioxygenase activity, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, tRNA demethylase activity; CC: cytoplasm, cytosol, nuclear speck, nucleus
Pathways: DNA Damage Reversal, DNA Repair, Reversal of alkylation damage by DNA dioxygenases
UniProt: Q8BGW1
Entrez ID: 26383
|
Does Knockout of Lhb in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Lhb
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lhb (luteinizing hormone beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, luteinizing hormone signaling pathway involved in ovarian follicle development, ovarian follicle development; MF: hormone activity; CC: cytoplasm, extracellular region, extracellular space, pituitary gonadotropin complex
Pathways: GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: G3X9G6
Entrez ID: 16866
|
Does Knockout of Cul2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cul2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cul2 (cullin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase binding; CC: Cul2-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, cullin-RING ubiquitin ligase complex, nuclear lumen, nucleolus, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, HIF-1 signaling pathway - Mus musculus (mouse), Immune System, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Renal cell carcinoma - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9D4H8
Entrez ID: 71745
|
Does Knockout of Ccdc27 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ccdc27
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ccdc27 (coiled-coil domain containing 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3V036
Entrez ID: 381580
|
Does Knockout of Dscam in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Dscam
|
response to virus
|
Microglial Cell Line
|
Gene: Dscam (DS cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, camera-type eye photoreceptor cell differentiation, cell adhesion, central nervous system development, dendrite morphogenesis, dendrite self-avoidance, dendritic spine development, homophilic cell adhesion via plasma membrane adhesion molecules, locomotory behavior, negative regulation of cell adhesion, nervous system development, netrin-activated signaling pathway, positive regulation of axon extension involved in axon guidance, positive regulation of phosphorylation, post-embryonic retina morphogenesis in camera-type eye, retina layer formation, social behavior, synapse assembly, synaptic transmission, glutamatergic; MF: cell-cell adhesion mediator activity, netrin receptor binding, protein binding, protein tyrosine kinase binding; CC: axon, cell projection, dendrite, growth cone, membrane, neuronal cell body, plasma membrane, synapse
Pathways: Axon guidance, DSCAM interactions, Developmental Biology, Nervous system development, Netrin-1 signaling
UniProt: Q9ERC8
Entrez ID: 13508
|
Does Knockout of Recql in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Recql
|
response to virus
|
Microglial Cell Line
|
Gene: Recql (RecQ protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, replication fork processing; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA/DNA annealing activity, double-stranded DNA helicase activity, four-way junction helicase activity, helicase activity, hydrolase activity, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding; CC: chromosome, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9Z129
Entrez ID: 19691
|
Does Knockout of Ranbp17 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Ranbp17
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ranbp17 (RAN binding protein 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, mRNA transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, small GTPase binding; CC: cytoplasm, nuclear pore, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q99NF8
Entrez ID: 66011
|
Does Knockout of Wee2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Wee2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wee2 (WEE1 homolog 2 (S. pombe))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female meiotic nuclear division, female pronucleus assembly, meiotic cell cycle, mitotic cell cycle, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of oocyte maturation, positive regulation of phosphorylation, regulation of fertilization, regulation of meiosis I; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Cell cycle - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse)
UniProt: Q66JT0
Entrez ID: 381759
|
Does Knockout of Klhl33 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Klhl33
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Klhl33 (kelch-like 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: G3UW92, A0A2I3BRZ3, B7ZMY3
Entrez ID: 546611
|
Does Knockout of Chfr in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Chfr
|
cell cycle progression
|
breast epithelium
|
Gene: Chfr (checkpoint with forkhead and ring finger domains)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic spindle checkpoint signaling, mitotic G2/M transition checkpoint, mitotic cell cycle, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, protein destabilization, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, nucleotide binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, nucleus
Pathways:
UniProt: Q810L3
Entrez ID: 231600
|
Does Knockout of Clhc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Clhc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Clhc1 (clathrin heavy chain linker domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5M6W3
Entrez ID: 73324
|
Does Knockout of Zcwpw1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Zcwpw1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zcwpw1 (zinc finger, CW type with PWWP domain 1)
Type: protein-coding
Summary: Enables histone H3K4me3 reader activity and methylated histone binding activity. Involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Acts upstream of or within homologous chromosome pairing at meiosis. Located in XY body and nucleus. Is expressed in brain; lung; reproductive system; and thymus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, chromatin organization, double-strand break repair involved in meiotic recombination, epigenetic regulation of gene expression, homologous chromosome pairing at meiosis, meiosis I, positive regulation of DNA recombination, positive regulation of double-strand break repair, spermatogenesis; MF: histone H3K36me3 reader activity, histone H3K4me3 reader activity, histone reader activity, metal ion binding, zinc ion binding; CC: XY body, chromosome, nucleus
Pathways:
UniProt: Q6IR42
Entrez ID: 381678
|
Does Knockout of Pamr1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Pamr1
|
cell proliferation
|
Regulatory T cell
|
Gene: Pamr1 (peptidase domain containing associated with muscle regeneration 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BU25
Entrez ID: 210622
|
Does Knockout of Aicda in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Aicda
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Aicda (activation-induced cytidine deaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA cytosine deamination, cellular response to lipopolysaccharide, cytidine to uridine editing, defense response to bacterium, defense response to virus, isotype switching, mRNA processing, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of gene expression via chromosomal CpG island demethylation, regulation of nuclear cell cycle DNA replication, somatic diversification of immunoglobulins, somatic hypermutation of immunoglobulin genes; MF: RNA binding, catalytic activity, cytidine deaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, identical protein binding, metal ion binding, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: P-body, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: (deoxy)ribose phosphate degradation, Intestinal immune network for IgA production - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse), purine and pyrimidine metabolism, pyrimidine deoxyribonucleosides degradation, pyrimidine ribonucleosides degradation II, salvage pathways of pyrimidine deoxyribonucleotides, salvage pathways of pyrimidine ribonucleotides
UniProt: Q9WVE0
Entrez ID: 11628
|
Does Knockout of Zfp747 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Zfp747
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp747 (zinc finger protein 747)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucocorticoid stimulus, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, transcription coregulator activity, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: A0A0U1RP29, Q8BHM7
Entrez ID: 269997
|
Does Knockout of Idh3b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Idh3b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Idh3b (isocitrate dehydrogenase 3 (NAD+) beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: NAD binding, magnesium ion binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein-macromolecule adaptor activity; CC: isocitrate dehydrogenase complex (NAD+), mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, TCA cycle variation III (eukaryotic)
UniProt: A0A668KL51, Q91VA7, V9GXV0
Entrez ID: 170718
|
Does Knockout of 4933427D14Rik in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
4933427D14Rik
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: 4933427D14Rik (RIKEN cDNA 4933427D14 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, cilium assembly, cytosolic ciliogenesis, protein localization to centrosome; CC: centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, microtubule organizing center
Pathways:
UniProt: Q6A000
Entrez ID: 74477
|
Does Knockout of Acr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Acr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acr (acrosin prepropeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome matrix dispersal, acrosome reaction, activation of adenylate cyclase activity, binding of sperm to zona pellucida, penetration of zona pellucida, protein catabolic process, proteolysis, response to steroid hormone, single fertilization; MF: D-mannose binding, amidase activity, fucose binding, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi-associated vesicle, acrosomal matrix, acrosomal vesicle, protein-containing complex
Pathways: Acrosome Reaction and Sperm:Oocyte Membrane Binding, Fertilization, Reproduction
UniProt: P23578
Entrez ID: 11434
|
Does Knockout of Gdi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gdi2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gdi2 (GDP dissociation inhibitor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cilium assembly, negative regulation of protein localization to cilium, protein transport, small GTPase-mediated signal transduction, vesicle-mediated transport; MF: GDP-dissociation inhibitor activity, GTPase activator activity, Rab GDP-dissociation inhibitor activity, protein binding, small GTPase binding; CC: Golgi apparatus, cytoplasm, cytosol, membrane, myelin sheath, synapse
Pathways: Immune System, Innate Immune System, Membrane Trafficking, Neutrophil degranulation, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q61598
Entrez ID: 14569
|
Does Knockout of Sh3tc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Sh3tc1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sh3tc1 (SH3 domain and tetratricopeptide repeats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TXV8, G3X9F6, Q3UDI4, F6QD49, F6UWL1, F6U4F1
Entrez ID: 231147
|
Does Knockout of Cep250 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cep250
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cep250 (centrosomal protein 250)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centriole-centriole cohesion, cilium assembly, detection of light stimulus involved in visual perception, intracellular protein localization, mitotic cell cycle, non-motile cilium assembly, positive regulation of protein localization to centrosome, protein localization to centrosome, regulation of centriole-centriole cohesion; MF: protein domain specific binding; CC: cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, perinuclear region of cytoplasm, photoreceptor inner segment, photoreceptor outer segment, protein-containing complex, spindle pole centrosome
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q60952
Entrez ID: 16328
|
Does Knockout of P3h4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
P3h4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic))
Type: protein-coding
Summary: Predicted to contribute to collagen binding activity. Involved in several processes, including collagen biosynthetic process; collagen fibril organization; and peptidyl-lysine hydroxylation. Part of catalytic complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human P3H4 (prolyl 3-hydroxylase family member 4 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: bone remodeling, collagen biosynthetic process, collagen fibril organization, peptidyl-lysine hydroxylation; MF: collagen binding, protein binding; CC: catalytic complex, endoplasmic reticulum, synaptonemal complex
Pathways:
UniProt: Q8K2B0
Entrez ID: 66180
|
Does Knockout of Psmd8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Psmd8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Psmd8 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; CC: nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9CX56
Entrez ID: 57296
|
Does Knockout of Mib1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Mib1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mib1 (MIB E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, blood vessel development, central nervous system neuron differentiation, endocytosis, heart development, heart looping, in utero embryonic development, negative regulation of neuron differentiation, neural tube formation, positive regulation of endocytosis, protein ubiquitination, somitogenesis, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: centriolar satellite, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, glutamatergic synapse, membrane, plasma membrane, postsynaptic density
Pathways: Lipid and atherosclerosis - Mus musculus (mouse)
UniProt: Q80SY4
Entrez ID: 225164
|
Does Knockout of Fbxo25 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fbxo25
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fbxo25 (F-box protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: actin binding, protein binding; CC: SCF ubiquitin ligase complex, cytoplasm, nucleus
Pathways: FoxO signaling pathway - Mus musculus (mouse)
UniProt: Q9D2Y6
Entrez ID: 66822
|
Does Knockout of Tmem165 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Tmem165
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmem165 (transmembrane protein 165)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi calcium ion homeostasis, Golgi calcium ion transport, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, manganese ion transmembrane transport, manganese ion transport, protein N-linked glycosylation, regulation of lysosomal lumen pH; MF: antiporter activity, calcium ion transmembrane transporter activity, manganese ion transmembrane transporter activity, metal ion transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, cis-Golgi network membrane, endosome membrane, lysosomal membrane, membrane, trans-Golgi network membrane
Pathways:
UniProt: P52875
Entrez ID: 21982
|
Does Knockout of Mt3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Mt3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mt3 (metallothionein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of protein kinase B activity, cellular detoxification, cellular response to cadmium ion, cellular response to copper ion, cellular response to hypoxia, cellular response to oxidative stress, cellular response to reactive oxygen species, cellular response to zinc ion, detoxification of cadmium ion, detoxification of copper ion, energy reserve metabolic process, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, leptin-mediated signaling pathway, negative regulation of apoptotic process, negative regulation of axon extension, negative regulation of cell growth, negative regulation of hydrogen peroxide catabolic process, negative regulation of neurogenesis, negative regulation of neuron apoptotic process, negative regulation of oxidoreductase activity, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of oxygen metabolic process, positive regulation of protein phosphorylation, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein stabilization, regulation of response to food, removal of superoxide radicals, response to hypoxia, response to oxidative stress, zinc ion transport; MF: cadmium ion binding, copper ion binding, metal ion binding, protein kinase activator activity, zinc ion binding; CC: astrocyte end-foot, astrocyte projection, axon, cytoplasm, cytosol, dendritic spine, extracellular space, inclusion body, microtubule, mitochondrial outer membrane, nucleus, perinuclear region of cytoplasm, ribosome, synaptic vesicle
Pathways: Cellular responses to stimuli, Metallothioneins bind metals, Response to metal ions
UniProt: P28184
Entrez ID: 17751
|
Does Knockout of Bicd2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Bicd2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bicd2 (BICD cargo adaptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centrosome localization, mRNA transport, microtubule anchoring at microtubule organizing center, microtubule-based movement, minus-end-directed organelle transport along microtubule, protein localization to Golgi apparatus, protein transport, regulation of microtubule cytoskeleton organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: cytoskeletal anchor activity, dynactin binding, dynein complex binding, dynein light intermediate chain binding, protein binding, small GTPase binding; CC: Golgi apparatus, annulate lamellae, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, nuclear envelope, nuclear pore, nucleus, plasma membrane
Pathways:
UniProt: Q921C5
Entrez ID: 76895
|
Does Knockout of Furin in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Furin
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Furin (furin, paired basic amino acid cleaving enzyme)
Type: protein-coding
Summary: This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: blastocyst formation, cytokine precursor processing, dibasic protein processing, negative regulation of low-density lipoprotein particle receptor catabolic process, negative regulation of transforming growth factor beta1 production, nerve growth factor production, peptide biosynthetic process, peptide hormone processing, positive regulation of cell migration, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of viral entry into host cell, protein maturation, protein processing, proteolysis, regulation of cholesterol transport, regulation of protein catabolic process, regulation of signal transduction, secretion by cell, signal peptide processing, symbiont entry into host cell, viral life cycle, zymogen activation, zymogen inhibition; MF: endopeptidase activator activity, endopeptidase activity, heparan sulfate binding, heparin binding, hydrolase activity, metal ion binding, nerve growth factor binding, peptidase activity, peptide binding, protease binding, protein binding, serine-type endopeptidase activity, serine-type endopeptidase inhibitor activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi apparatus subcompartment, Golgi cisterna, Golgi lumen, Golgi membrane, cell surface, cytoplasmic vesicle, early endosome, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular region, membrane, membrane raft, organelle membrane, plasma membrane, trans-Golgi network, trans-Golgi network transport vesicle, trans-Golgi network transport vesicle membrane
Pathways: Activation of Matrix Metalloproteinases, Adherens junctions interactions, Assembly of active LPL and LIPC lipase complexes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Collagen degradation, Degradation of the extracellular matrix, Elastic fibre formation, Expression and Processing of Neurotrophins, Extracellular matrix organization, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, NGF processing, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Post-translational protein modification, Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Removal of aminoterminal propeptides from gamma-carboxylated proteins, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by NOTCH, Signaling by NTRKs, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transport of small molecules
UniProt: P23188
Entrez ID: 18550
|
Does Knockout of Cyp3a13 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Cyp3a13
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cyp3a13 (cytochrome P450, family 3, subfamily a, polypeptide 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: oxidative demethylation, positive regulation of gene expression, steroid metabolic process, xenobiotic transport; MF: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity, caffeine oxidase activity, enzyme binding, estrogen 16-alpha-hydroxylase activity, estrogen 2-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity, steroid binding, steroid hydroxylase activity, testosterone 6-beta-hydroxylase activity, vitamin D 24-hydroxylase activity, vitamin D3 25-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Aflatoxin activation and detoxification, Aspirin ADME, Atorvastatin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Prednisone ADME, Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q64464
Entrez ID: 13113
|
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