prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ncam2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Ncam2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ncam2 (neural cell adhesion molecule 2)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in axonal fasciculation and cell adhesion. Located in axon. Is active in synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axonal fasciculation, cell adhesion; MF: identical protein binding; CC: axon, membrane, neuron projection, nuclear body, plasma membrane, side of membrane, synaptic membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse), Prion disease - Mus musculus (mouse)
UniProt: O35136
Entrez ID: 17968
|
Does Knockout of Gzmm in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Gzmm
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gzmm (granzyme M (lymphocyte met-ase 1))
Type: protein-coding
Summary: The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: T cell mediated cytotoxicity, apoptotic process, protein maturation, proteolysis; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Alternative complement activation, Complement cascade, Immune System, Initial triggering of complement, Innate Immune System
UniProt: B7ZP17, O08643
Entrez ID: 16904
|
Does Knockout of Dad1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 1,716
|
Knockout
|
Dad1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Dad1 (defender against cell death 1)
Type: protein-coding
Summary: Predicted to enable enzyme activator activity. Acts upstream of or within blastocyst development and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of apoptotic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability; MF: enzyme activator activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: P61804
Entrez ID: 13135
|
Does Knockout of Sftpc in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Sftpc
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Sftpc (surfactant associated protein C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: alveolar lamellar body, cytoplasm, extracellular region, extracellular space, multivesicular body
Pathways:
UniProt: Q6P8P8
Entrez ID: 20389
|
Does Knockout of Col7a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Col7a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Col7a1 (collagen, type VII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, collagen fibril organization; MF: extracellular matrix structural constituent conferring tensile strength, identical protein binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, collagen trimer, extracellular matrix, extracellular region
Pathways: Anchoring fibril formation, Asparagine N-linked glycosylation, Assembly of collagen fibrils and other multimeric structures, COPII-mediated vesicle transport, Cargo concentration in the ER, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, ER to Golgi Anterograde Transport, Extracellular matrix organization, Fibronectin matrix formation, Integrin cell surface interactions, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein digestion and absorption - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q63870
Entrez ID: 12836
|
Does Knockout of Btbd3 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Btbd3
|
cell proliferation
|
Regulatory T cell
|
Gene: Btbd3 (BTB domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebral cortex development, dendrite morphogenesis, nervous system development, neurogenesis; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: P58545
Entrez ID: 228662
|
Does Knockout of Inpp4a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Inpp4a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Inpp4a (inositol polyphosphate-4-phosphatase, type I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, polyphosphate catabolic process, regulation of postsynaptic membrane neurotransmitter receptor levels, small molecule metabolic process; MF: hydrolase activity, inositol-1,3,4-trisphosphate 4-phosphatase activity, inositol-3,4-bisphosphate 4-phosphatase activity, phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; CC: cytoplasm, early endosome membrane, endosome, glutamatergic synapse, membrane, nuclear membrane, nucleoplasm, nucleus, organelle, plasma membrane, postsynaptic density, recycling endosome membrane, synapse
Pathways: Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane
UniProt: Q9EPW0
Entrez ID: 269180
|
Does Knockout of Adgrf3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Adgrf3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adgrf3 (adhesion G protein-coupled receptor F3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity
Pathways:
UniProt: Q58Y75
Entrez ID: 381628
|
Does Knockout of Prss21 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Prss21
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prss21 (serine protease 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis, spermatogenesis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9JHJ7
Entrez ID: 57256
|
Does Knockout of Vps33a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Vps33a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vps33a (VPS33A CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, endosome to lysosome transport, intracellular protein transport, lysosome localization, melanosome localization, pigmentation, platelet formation, protein transport, regulation of developmental pigmentation, regulation of lysosomal lumen pH, vesicle-mediated transport; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, autophagosome, clathrin complex, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q9D2N9
Entrez ID: 77573
|
Does Knockout of Irf4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Irf4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Irf4 (interferon regulatory factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 17 cell lineage commitment, chromatin remodeling, defense response to protozoan, dendritic cell differentiation, immune system process, lymphocyte activation involved in immune response, lymphocyte differentiation, myeloid cell differentiation, myeloid dendritic cell differentiation, negative regulation of toll-like receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of cold-induced thermogenesis, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-2 production, positive regulation of interleukin-4 production, positive regulation of multicellular organismal process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator activity; CC: cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus
Pathways: Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q64287
Entrez ID: 16364
|
Does Knockout of Sema3b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Sema3b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sema3b (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B)
Type: protein-coding
Summary: This gene encodes a secreted protein that belongs to the class 3 semaphorin/collapsin family. Members of this family play a role in growth cone guidance during neurogenesis. The encoded protein inhibits axonal extension. This protein is thought to be an osteoblast protein that regulates bone mass and affects skeletal homeostasis. A similar gene in humans functions as a tumor suppressor gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: axon guidance, cell differentiation, negative chemotaxis, negative regulation of developmental process, negative regulation of multicellular organismal process, nervous system development, neural crest cell migration, positive regulation of cell migration, regulation of anatomical structure morphogenesis, regulation of multicellular organismal development, semaphorin-plexin signaling pathway; MF: chemorepellent activity, neuropilin binding, semaphorin receptor binding; CC: extracellular region, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q0VGP2, M9MMK0, A0A0A6YW56, A0A0A6YWM9, A0A0A6YXC1, A0A0A6YWW1, A0A0G2JDD7, M0QWQ7
Entrez ID: 20347
|
Does Knockout of Syt7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Syt7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Syt7 (synaptotagmin VII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion regulated lysosome exocytosis, calcium ion-regulated exocytosis of neurotransmitter, calcium-dependent activation of synaptic vesicle fusion, calcium-ion regulated exocytosis, exocytosis, phagocytosis, phagosome-lysosome fusion, plasma membrane repair, positive regulation of calcium ion-dependent exocytosis, positive regulation of transport, regulation of bone remodeling, regulation of calcium ion-dependent exocytosis, regulation of dopamine secretion, regulation of endocytosis, regulation of glucagon secretion, regulation of insulin secretion, regulation of phagocytosis, regulation of synaptic vesicle endocytosis, short-term synaptic potentiation, synaptic vesicle recycling, vesicle fusion, vesicle-mediated cholesterol transport, vesicle-mediated transport; MF: SNARE binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, calmodulin binding, clathrin binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, protein binding, syntaxin binding; CC: GABA-ergic synapse, axon, axon terminus, cell projection, cytoplasmic vesicle, cytosol, dendrite, dense core granule, early phagosome, endomembrane system, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, lysosomal membrane, lysosome, membrane, neuronal cell body, peroxisomal membrane, peroxisome, phagocytic vesicle membrane, plasma membrane, presynaptic membrane, secretory vesicle, synapse, synaptic vesicle, synaptic vesicle membrane, transport vesicle membrane
Pathways:
UniProt: Q9R0N7
Entrez ID: 54525
|
Does Knockout of Tmem87a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tmem87a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmem87a (transmembrane protein 87A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to mechanical stimulus, detection of mechanical stimulus involved in sensory perception of touch, retrograde transport, endosome to Golgi; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, cell projection, cytosol, membrane, plasma membrane, ruffle
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BXN9
Entrez ID: 211499
|
Does Knockout of Spin1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Spin1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Spin1 (spindlin 1)
Type: protein-coding
Summary: Enables histone reader activity and methylated histone binding activity. Involved in protein localization to chromatin and transposable element silencing by piRNA-mediated DNA methylation. Located in spindle. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: Wnt signaling pathway, chromatin organization, female meiotic nuclear division, gamete generation, meiotic cell cycle, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, protein localization to chromatin, rRNA transcription, regulation of DNA-templated transcription, transposable element silencing by piRNA-mediated DNA methylation; MF: DNA binding, histone H3K4me3 reader activity, histone reader activity; CC: chromatin, cytoplasm, cytoskeleton, cytosol, nuclear membrane, nucleolus, nucleoplasm, nucleus, spindle
Pathways:
UniProt: Q61142
Entrez ID: 20729
|
Does Knockout of Rnf145 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Rnf145
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rnf145 (ring finger protein 145)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q5SWK7
Entrez ID: 74315
|
Does Knockout of Vax1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Vax1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vax1 (ventral anterior homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: astrocyte differentiation, axon guidance, brain development, camera-type eye development, central nervous system development, glial cell differentiation, negative regulation of neuroblast proliferation, negative regulation of transcription by RNA polymerase II, nervous system development, neuroepithelial cell differentiation, neuron differentiation, neuron migration, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, roof of mouth development, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q2NKI2
Entrez ID: 22326
|
Does Knockout of Tmem101 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Tmem101
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem101 (transmembrane protein 101)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q91VP7
Entrez ID: 76547
|
Does Knockout of Vmn2r115 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 163
|
Knockout
|
Vmn2r115
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn2r115 (vomeronasal 2, receptor 115)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3Q4L389, E9Q0E7
Entrez ID: 638102
|
Does Knockout of Ptpra in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Ptpra
|
cell cycle progression
|
breast epithelium
|
Gene: Ptpra (protein tyrosine phosphatase receptor type A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin receptor signaling pathway, integrin-mediated signaling pathway, modulation of chemical synaptic transmission, positive regulation of oligodendrocyte differentiation, regulation of focal adhesion assembly, signal transduction; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity, protein-containing complex binding; CC: Schaffer collateral - CA1 synapse, anchoring junction, focal adhesion, membrane, plasma membrane, receptor complex, synaptic membrane
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NCAM signaling for neurite out-growth, Nervous system development, RAF/MAP kinase cascade, Signal Transduction
UniProt: P18052
Entrez ID: 19262
|
Does Knockout of Dnajc15 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Dnajc15
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Dnajc15 (DnaJ heat shock protein family (Hsp40) member C15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to starvation, negative regulation of mitochondrial electron transport, NADH to ubiquinone, negative regulation of protein-containing complex assembly, protein import into mitochondrial matrix, protein transport, regulation of lipid metabolic process; MF: ATPase activator activity, protein binding; CC: PAM complex, Tim23 associated import motor, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q78YY6
Entrez ID: 66148
|
Does Knockout of Ndor1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ndor1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ndor1 (NADPH dependent diflavin oxidoreductase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: electron transport chain, iron-sulfur cluster assembly; MF: FAD binding, FMN binding, NADP binding, NADPH binding, NADPH-hemoprotein reductase activity, NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity, electron transfer activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; CC: cytoplasm, cytosol, intermediate filament cytoskeleton, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: A2AI05
Entrez ID: 78797
|
Does Knockout of P3h2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
P3h2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: P3h2 (prolyl 3-hydroxylase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen metabolic process, negative regulation of cell population proliferation, peptidyl-proline hydroxylation; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity; CC: Golgi apparatus, basement membrane, cytosol, endoplasmic reticulum, nucleoplasm, sarcoplasmic reticulum
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization
UniProt: Q8CG71
Entrez ID: 210530
|
Does Knockout of Ak6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ak6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ak6 (adenylate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleoside monophosphate phosphorylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: AMP kinase activity, ATP binding, ATP hydrolysis activity, kinase activity, nucleotide binding, transferase activity; CC: Cajal body, centrosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q8VCP8
Entrez ID: 102216272
|
Does Knockout of Kitl in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Kitl
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kitl (kit ligand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell adhesion, developmental process involved in reproduction, ectopic germ cell programmed cell death, embryonic hemopoiesis, extrinsic apoptotic signaling pathway in absence of ligand, germ cell development, male gonad development, mast cell migration, melanocyte migration, negative regulation of apoptotic process, negative regulation of mast cell apoptotic process, neural crest cell migration, ovarian follicle development, positive regulation of Ras protein signal transduction, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of hematopoietic stem cell proliferation, positive regulation of leukocyte migration, positive regulation of mast cell proliferation, positive regulation of melanocyte differentiation, positive regulation of myeloid leukocyte differentiation; MF: cytokine activity, growth factor activity, protein binding, stem cell factor receptor binding; CC: cell projection, cytoplasm, cytoskeleton, extracellular region, extracellular space, filopodium, lamellipodium, membrane, plasma membrane
Pathways: Developmental Biology, Hematopoietic cell lineage - Mus musculus (mouse), Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of KIT signaling, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: P20826
Entrez ID: 17311
|
Does Knockout of Arap1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Arap1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Arap1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of stress fiber assembly, photoreceptor cell maintenance, positive regulation of DNA-templated transcription, positive regulation of cellular component organization, positive regulation of filopodium assembly, positive regulation of phagocytosis, positive regulation of receptor recycling, regulation of actin cytoskeleton organization, regulation of bone resorption, regulation of cell projection organization, regulation of cell shape, regulation of endocytosis, regulation of receptor internalization, signal transduction, transforming growth factor beta receptor signaling pathway; MF: DNA-binding transcription factor activity, GTPase activator activity, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, transcription cis-regulatory region binding, type 1 angiotensin receptor binding, zinc ion binding; CC: Golgi apparatus, Golgi cisterna membrane, anchoring junction, cell projection, cytoplasm, cytosol, early endosome, endosome, extrinsic component of plasma membrane, membrane, multivesicular body, nucleoplasm, plasma membrane, podosome, ruffle, trans-Golgi network
Pathways: CDC42 GTPase cycle, Endocytosis - Mus musculus (mouse), PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q4LDD4
Entrez ID: 69710
|
Does Knockout of Npy5r in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Npy5r
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Npy5r (neuropeptide Y receptor Y5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cardiac left ventricle morphogenesis, chemical synaptic transmission, eating behavior, generation of ovulation cycle rhythm, negative regulation of acute inflammatory response to antigenic stimulus, negative regulation of apoptotic process, negative regulation of glutamate secretion, negative regulation of synaptic transmission, GABAergic, neuropeptide signaling pathway, outflow tract morphogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of acute inflammatory response, positive regulation of cell population proliferation, positive regulation of smooth muscle cell proliferation, signal transduction, synaptic signaling via neuropeptide; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, pancreatic polypeptide receptor activity, peptide YY receptor activity; CC: GABA-ergic synapse, membrane, neuron projection, plasma membrane, presynapse
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O70342
Entrez ID: 18168
|
Does Knockout of Gtpbp4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gtpbp4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gtpbp4 (GTP binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of DNA replication, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of protein ubiquitination, protein stabilization, ribosomal large subunit biogenesis, ribosome biogenesis; MF: GTP binding, GTPase activity, RNA binding, nucleotide binding, preribosome binding; CC: cytoplasm, cytosol, nuclear membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99ME9
Entrez ID: 69237
|
Does Knockout of Trim39 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Trim39
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Trim39 (tripartite motif-containing 39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, innate immune response, mitotic G2 DNA damage checkpoint signaling, negative regulation of canonical NF-kappaB signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of apoptotic signaling pathway, protein stabilization, protein ubiquitination, regulation of cell cycle G1/S phase transition, regulation of gene expression; MF: identical protein binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, mitochondrion, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9ESN2
Entrez ID: 79263
|
Does Knockout of Trim55 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Trim55
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Trim55 (tripartite motif-containing 55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cellular response to lipopolysaccharide, defense response to virus, diapedesis, inflammatory response, innate immune response, leukocyte migration involved in inflammatory response, macrophage activation, macrophage migration, positive regulation of non-canonical NF-kappaB signal transduction, protein K48-linked ubiquitination, protein K63-linked ubiquitination, regulation of transcription by RNA polymerase II; MF: identical protein binding, metal ion binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: G3X8Y1
Entrez ID: 381485
|
Does Knockout of Inpp1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Inpp1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Inpp1 (inositol polyphosphate-1-phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, inositol-1,3,4-trisphosphate 1-phosphatase activity, inositol-1,4-bisphosphate 1-phosphatase activity, metal ion binding
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP2, IP, and Ins in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: P49442
Entrez ID: 16329
|
Does Knockout of Zfp966 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Zfp966
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Zfp966 (zinc finger protein 966)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Pathways:
UniProt: A2ART2, A2ART1, E9PXD4, A0A571BD11, A0A571BEZ8, A0A571BF26, A0A571BGA5
Entrez ID: 667962
|
Does Knockout of Ccdc89 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Ccdc89
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccdc89 (coiled-coil domain containing 89)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, nucleus
Pathways:
UniProt: Q9DA73
Entrez ID: 70054
|
Does Knockout of Mir7233 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mir7233
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mir7233 (microRNA 7233)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466996
|
Does Knockout of Bloc1s1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Bloc1s1
|
phagocytosis
|
macrophage
|
Gene: Bloc1s1 (biogenesis of lysosomal organelles complex-1, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, anterograde axonal transport, anterograde synaptic vesicle transport, endosomal transport, lysosome localization, melanosome organization, neuron projection development, organelle transport along microtubule, peptidyl-lysine acetylation, regulation of endosome size, regulation of lysosome size; MF: protein binding, protein-lysine-acetyltransferase activity, transferase activity; CC: BLOC-1 complex, BORC complex, axon cytoplasm, cytoplasm, cytoplasmic side of lysosomal membrane, cytosol, early endosome, lysosomal membrane, lysosome, membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: O55102
Entrez ID: 14533
|
Does Knockout of Fam180a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Fam180a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam180a (family with sequence similarity 180, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q8BR21
Entrez ID: 208164
|
Does Knockout of Npr1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Npr1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Npr1 (natriuretic peptide receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel diameter maintenance, cGMP biosynthetic process, cGMP-mediated signaling, cell surface receptor signaling pathway, cyclic nucleotide biosynthetic process, dopamine metabolic process, intracellular signal transduction, negative regulation of smooth muscle cell proliferation, positive regulation of cGMP-mediated signaling, receptor guanylyl cyclase signaling pathway, regulation of blood pressure, regulation of vascular permeability; MF: ATP binding, GTP binding, guanylate cyclase activity, hormone binding, lyase activity, natriuretic peptide receptor activity, nucleotide binding, peptide hormone binding, peptide receptor activity, phosphorus-oxygen lyase activity, protein kinase activity; CC: ANPR-A receptor complex, membrane, plasma membrane, receptor complex
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Cardiac conduction, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Physiological factors, Purine metabolism - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: P18293
Entrez ID: 18160
|
Does Knockout of Tcf7 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Tcf7
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Tcf7 (transcription factor 7, T cell specific)
Type: protein-coding
Summary: This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: T cell receptor V(D)J recombination, Wnt signaling pathway, alpha-beta T cell differentiation, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in negative regulation of apoptotic process, cell differentiation, cellular response to interleukin-4, embryonic digestive tract morphogenesis, embryonic genitalia morphogenesis, embryonic hindgut morphogenesis, gamma-delta T cell differentiation, immune system process, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, neural tube development, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of gamma-delta T cell differentiation, regulation of transcription by RNA polymerase II, tissue development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: beta-catenin-TCF complex, chromatin, euchromatin, nuclear body, nucleoplasm, nucleus
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Developmental Biology, Endometrial cancer - Mus musculus (mouse), Formation of the beta-catenin:TCF transactivating complex, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Repression of WNT target genes, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Thyroid cancer - Mus musculus (mouse), Transcriptional regulation by RUNX3, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q00417
Entrez ID: 21414
|
Does Knockout of Hmx1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Hmx1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hmx1 (H6 homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: O70218
Entrez ID: 15371
|
Does Knockout of Slc34a1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Slc34a1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc34a1 (solute carrier family 34 (sodium phosphate), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsenate ion transmembrane transport, bone remodeling, calcium ion homeostasis, cellular response to phosphate starvation, gene expression, inorganic diphosphate transport, intracellular phosphate ion homeostasis, monoatomic ion transport, phosphate ion homeostasis, phosphate ion transmembrane transport, phosphate ion transport, positive regulation of membrane potential, positive regulation of phosphate transmembrane transport, positive regulation of sodium-dependent phosphate transport, response to cadmium ion, response to lead ion, response to mercury ion, response to sodium phosphate, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport, sodium-dependent phosphate transport, transmembrane transport; MF: PDZ domain binding, identical protein binding, protein binding, protein-containing complex binding, sodium:phosphate symporter activity, symporter activity; CC: apical plasma membrane, basolateral plasma membrane, brush border, brush border membrane, cell surface, cytosol, endosome, membrane, mitotic spindle, nuclear speck, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, vesicle
Pathways: Mineral absorption - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: A0A286YCG7, Q9D2V6
Entrez ID: 20505
|
Does Knockout of Pld3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Pld3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pld3 (phospholipase D family member 3)
Type: protein-coding
Summary: Enables single-stranded DNA 5'-3' DNA exonuclease activity. Involved in regulation of cytokine production involved in inflammatory response. Located in late endosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to human PLD3 (phospholipase D family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA metabolic process, immune system process, inflammatory response, innate immune response, lipid metabolic process, myotube differentiation, regulation of cytokine production involved in inflammatory response; MF: catalytic activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, phospholipase D activity, single-stranded DNA 5'-3' DNA exonuclease activity; CC: Golgi apparatus, Golgi membrane, early endosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, late endosome membrane, lysosomal lumen, lysosomal membrane, lysosome, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Role of phospholipids in phagocytosis, choline biosynthesis III, phospholipases
UniProt: O35405
Entrez ID: 18807
|
Does Knockout of Samd12 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Samd12
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Samd12 (sterile alpha motif domain containing 12)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 1. Orthologous to human SAMD12 (sterile alpha motif domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q0VE29
Entrez ID: 320679
|
Does Knockout of Iqsec1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Iqsec1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Iqsec1 (IQ motif and Sec7 domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, dendritic spine development, positive regulation of focal adhesion disassembly, positive regulation of keratinocyte migration, positive regulation of synapse assembly, postsynaptic modulation of chemical synaptic transmission, regulation of ARF protein signal transduction, regulation of postsynaptic neurotransmitter receptor internalization; MF: guanyl-nucleotide exchange factor activity, lipid binding, protein kinase binding; CC: Schaffer collateral - CA1 synapse, centrosome, cytoplasm, cytoplasmic vesicle, cytosol, glutamatergic synapse, nucleoplasm, nucleus, postsynaptic density, postsynaptic density, intracellular component, synapse, synaptic vesicle
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q8R0S2
Entrez ID: 232227
|
Does Knockout of Dse in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Dse
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dse (dermatan sulfate epimerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chondroitin sulfate proteoglycan metabolic process, dermatan sulfate proteoglycan biosynthetic process, dermatan sulfate proteoglycan metabolic process, heparan sulfate proteoglycan biosynthetic process; MF: chondroitin-glucuronate 5-epimerase activity, isomerase activity, metal ion binding; CC: Golgi apparatus, Golgi membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, dermatan sulfate biosynthesis, dermatan sulfate biosynthesis (late stages)
UniProt: Q8BLI4
Entrez ID: 212898
|
Does Knockout of Ttll5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ttll5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, elongating, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, nucleus, plasma membrane
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q8CHB8
Entrez ID: 320244
|
Does Knockout of Wbp1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Wbp1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wbp1l (WW domain binding protein 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CXCL12-activated CXCR4 signaling pathway, hemopoiesis, positive regulation of protein ubiquitination; CC: cellular_component, membrane
Pathways:
UniProt: Q8BGW2
Entrez ID: 226178
|
Does Knockout of Me3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Me3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Me3 (malic enzyme 3, NADP(+)-dependent, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: malate metabolic process, pyruvate biosynthetic process, pyruvate metabolic process; MF: NAD binding, NADP+ binding, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, metal ion binding, oxaloacetate decarboxylase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, PPAR signaling pathway - Mus musculus (mouse), Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), gluconeogenesis I
UniProt: Q8BMF3
Entrez ID: 109264
|
Does Knockout of Slc38a8 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Slc38a8
|
response to virus
|
Microglial Cell Line
|
Gene: Slc38a8 (solute carrier family 38, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, amino acid transmembrane transport, amino acid transport, aspartate metabolic process, neuron projection development, optic nerve development, response to virus, retina development in camera-type eye, retinal pigment epithelium development, viral genome replication, visual perception; CC: axon, cell cortex, cell projection, cellular_component, cytoplasm, membrane
Pathways:
UniProt: Q5HZH7
Entrez ID: 234788
|
Does Knockout of Vps9d1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Vps9d1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Vps9d1 (VPS9 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, identical protein binding, molecular_function, small GTPase binding; CC: cytosol, endocytic vesicle
Pathways:
UniProt: Q8C190
Entrez ID: 72325
|
Does Knockout of Vegfd in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Vegfd
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vegfd (vascular endothelial growth factor D)
Type: protein-coding
Summary: This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: angiogenesis, cell differentiation, dopaminergic neuron differentiation, fibroblast proliferation, induction of positive chemotaxis, positive chemotaxis, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of interleukin-6 production, positive regulation of mast cell chemotaxis, regulation of vascular endothelial growth factor receptor signaling pathway, response to bacterium, response to hypoxia, sprouting angiogenesis, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway; MF: chemoattractant activity, growth factor activity, identical protein binding, protein binding, vascular endothelial growth factor receptor 3 binding, vascular endothelial growth factor receptor binding; CC: extracellular region, extracellular space, membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Hemostasis, MAPK signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, TNF signaling pathway - Mus musculus (mouse), VEGF binds to VEGFR leading to receptor dimerization, VEGF ligand-receptor interactions
UniProt: P97946
Entrez ID: 14205
|
Does Knockout of Lef1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Lef1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lef1 (lymphoid enhancer binding factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, BMP signaling pathway, T cell receptor V(D)J recombination, T-helper 1 cell differentiation, Wnt signaling pathway, alpha-beta T cell differentiation, anatomical structure regression, apoptotic process involved in blood vessel morphogenesis, apoptotic process involved in morphogenesis, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cell adhesion, cell chemotaxis, cell development, cell differentiation, cellular response to cytokine stimulus, cellular response to interleukin-4, chorio-allantoic fusion, dentate gyrus development, embryonic limb morphogenesis, epithelial cell apoptotic process, epithelial to mesenchymal transition, face morphogenesis, forebrain neuroblast division, forebrain radial glial cell differentiation, formation of radial glial scaffolds, hippocampus development, host-mediated activation of viral transcription, mammary gland development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of apoptotic process in bone marrow cell, negative regulation of interleukin-13 production, negative regulation of interleukin-4 production, negative regulation of interleukin-5 production, negative regulation of striated muscle tissue development, negative regulation of transcription by RNA polymerase II, neutrophil differentiation, odontoblast differentiation, odontogenesis of dentin-containing tooth, osteoblast differentiation, paraxial mesoderm formation, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, positive regulation of cell cycle process, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell proliferation in bone marrow, positive regulation of chondrocyte proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of gamma-delta T cell differentiation, positive regulation of gene expression, positive regulation of granulocyte differentiation, positive regulation of odontoblast differentiation, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of Wnt signaling pathway, regulation of cell-cell adhesion, regulation of neurogenesis, regulation of transcription by RNA polymerase II, secondary palate development, sensory perception of taste, somitogenesis, sprouting angiogenesis, tissue development, tongue development, trachea gland development, vasculature development; MF: C2H2 zinc finger domain binding, DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, armadillo repeat domain binding, beta-catenin binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, gamma-catenin binding, histone deacetylase binding, nuclear estrogen receptor binding, nucleic acid binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription corepressor binding, transcription regulator inhibitor activity; CC: RNA polymerase II transcription regulator complex, beta-catenin-TCF complex, chromatin, cytoplasm, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Developmental Biology, Endometrial cancer - Mus musculus (mouse), Formation of the beta-catenin:TCF transactivating complex, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Repression of WNT target genes, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Thyroid cancer - Mus musculus (mouse), Transcriptional regulation by RUNX3, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P27782
Entrez ID: 16842
|
Does Knockout of Cinp in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Cinp
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cinp (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, biological_process, cell division, ribosomal large subunit biogenesis, ribosome biogenesis; MF: molecular_function, preribosome binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D0V8
Entrez ID: 67236
|
Does Knockout of Wnt2b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Wnt2b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Wnt2b (wingless-type MMTV integration site family, member 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, animal organ morphogenesis, canonical Wnt signaling pathway, cell fate commitment, cell-cell signaling, cellular response to starvation, chondrocyte differentiation, forebrain regionalization, hematopoietic stem cell proliferation, lung induction, male gonad development, mesenchymal-epithelial cell signaling, neuron differentiation, positive regulation of branching involved in ureteric bud morphogenesis, signal transduction, system development; MF: cytokine activity, frizzled binding, protein binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), WNT ligand biogenesis and trafficking, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: O70283
Entrez ID: 22414
|
Does Knockout of Fam131c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Fam131c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam131c (family with sequence similarity 131, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2ADB2
Entrez ID: 277743
|
Does Knockout of Gtf2ird2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gtf2ird2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gtf2ird2 (GTF2I repeat domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of skeletal muscle adaptation, transition between fast and slow fiber; MF: DNA binding, protein binding; CC: nucleus
Pathways:
UniProt: Q99NI3
Entrez ID: 114674
|
Does Knockout of Klc4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Klc4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Klc4 (kinesin light chain 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axo-dendritic transport, microtubule-based movement; CC: ciliary rootlet, cytoplasm, cytoskeleton, kinesin complex, microtubule, neuron projection
Pathways: Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9DBS5
Entrez ID: 74764
|
Does Knockout of Tmem259 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tmem259
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem259 (transmembrane protein 259)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of ERAD pathway, response to endoplasmic reticulum stress; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8CIV2
Entrez ID: 216157
|
Does Knockout of Sectm1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Sectm1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sectm1a (secreted and transmembrane 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, interleukin-2-mediated signaling pathway, positive regulation of T cell cytokine production, signal transduction; MF: cytokine activity, receptor ligand activity; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: A2ABP7, A2ABP9, Q3TBH1, A2ABP8
Entrez ID: 209588
|
Does Knockout of Adora2b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Adora2b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Adora2b (adenosine A2b receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of cell population proliferation, negative regulation of collagen biosynthetic process, positive regulation of cAMP/PKA signal transduction, positive regulation of cGMP-mediated signaling, positive regulation of catecholamine secretion, positive regulation of cell population proliferation, positive regulation of chemokine production, positive regulation of chronic inflammatory response to non-antigenic stimulus, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of interleukin-6 production, positive regulation of mast cell degranulation, positive regulation of norepinephrine secretion, positive regulation of steroid biosynthetic process, positive regulation of vascular endothelial growth factor production, presynaptic modulation of chemical synaptic transmission, regulation of cell communication, regulation of glucose metabolic process, regulation of signaling, relaxation of vascular associated smooth muscle, response to angiotensin, signal transduction, vasodilation; MF: G protein-coupled adenosine receptor activity, G protein-coupled receptor activity; CC: Schaffer collateral - CA1 synapse, cell surface, glutamatergic synapse, membrane, plasma membrane, presynapse, synapse
Pathways: Adenosine P1 receptors, Alcoholism - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Surfactant metabolism, Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: Q60614
Entrez ID: 11541
|
Does Knockout of Pid1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Pid1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Pid1 (phosphotyrosine interaction domain containing 1)
Type: protein-coding
Summary: Involved in several processes, including cellular response to cytokine stimulus; negative regulation of D-glucose import; and positive regulation of ATP biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system and retina. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to cytokine stimulus, cellular response to fatty acid, cellular response to interleukin-6, cellular response to leptin stimulus, cellular response to tumor necrosis factor, mitochondrion organization, negative regulation of ATP biosynthetic process, negative regulation of D-glucose import, negative regulation of insulin receptor signaling pathway, negative regulation of protein localization to plasma membrane, positive regulation of ATP biosynthetic process, positive regulation of biosynthetic process, positive regulation of fat cell proliferation, positive regulation of gene expression, positive regulation of nucleobase-containing compound metabolic process, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, regulation of ATP biosynthetic process, regulation of cell population proliferation, regulation of mitochondrial membrane potential, regulation of reactive oxygen species metabolic process; CC: cytoplasm
Pathways:
UniProt: Q3UBG2
Entrez ID: 98496
|
Does Knockout of Eif4a3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Eif4a3
|
cell cycle progression
|
breast epithelium
|
Gene: Eif4a3 (eukaryotic translation initiation factor 4A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, embryonic cranial skeleton morphogenesis, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, negative regulation of excitatory postsynaptic potential, negative regulation of gene expression, negative regulation of selenocysteine incorporation, negative regulation of translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, positive regulation of translation, rRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, poly(A) binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding; CC: U2-type catalytic step 1 spliceosome, catalytic step 2 spliceosome, cytoplasm, dendrite, exon-exon junction complex, glutamatergic synapse, neuronal cell body, nuclear speck, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), ISG15 antiviral mechanism, Immune System, Interferon Signaling, Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q91VC3
Entrez ID: 192170
|
Does Knockout of Zfp790 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zfp790
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zfp790 (zinc finger protein 790)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q80ZX2
Entrez ID: 233056
|
Does Knockout of Nop14 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Nop14
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nop14 (NOP14 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: enzyme binding, snoRNA binding; CC: Noc4p-Nop14p complex, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R3N1
Entrez ID: 75416
|
Does Knockout of Tpm4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tpm4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tpm4 (tropomyosin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, muscle contraction, platelet formation; MF: actin binding, actin filament binding, identical protein binding, metal ion binding, protein heterodimerization activity, protein homodimerization activity; CC: actin cytoskeleton, actin filament, cortical cytoskeleton, cytoplasm, cytoskeleton, podosome, stress fiber
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, RHO GTPase cycle, RHOV GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Smooth Muscle Contraction, Striated Muscle Contraction
UniProt: Q6IRU2
Entrez ID: 326618
|
Does Knockout of Dguok in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Dguok
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dguok (deoxyguanosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dAMP salvage, dGMP salvage, dGTP metabolic process, dIMP salvage, mitochondrial ATP synthesis coupled electron transport, negative regulation of neuron projection development, nucleobase-containing compound metabolic process, purine deoxyribonucleoside metabolic process; MF: ATP binding, deoxyadenosine kinase activity, deoxyguanosine kinase activity, deoxynucleoside kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine metabolism - Mus musculus (mouse), Purine salvage
UniProt: Q9QX60
Entrez ID: 27369
|
Does Knockout of Cerkl in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Cerkl
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cerkl (ceramide kinase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, sphingolipid biosynthetic process, sphingolipid metabolic process; MF: kinase activity, lipid kinase activity, sphingolipid binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, photoreceptor inner segment, photoreceptor outer segment
Pathways:
UniProt: A2AQH0, A2AQH1
Entrez ID: 228094
|
Does Knockout of Neil3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Neil3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Neil3 (nei like 3 (E. coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, interstrand cross-link repair, single strand break repair; MF: DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) endonuclease activity, MCM complex binding, bubble DNA binding, catalytic activity, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, double-stranded DNA binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, lyase activity, metal ion binding, nucleic acid binding, single-stranded DNA binding, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged purine, DNA Repair, Depurination, Recognition and association of DNA glycosylase with site containing an affected purine
UniProt: Q8K203
Entrez ID: 234258
|
Does Knockout of Ostm1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Ostm1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ostm1 (osteopetrosis associated transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: osteoclast differentiation, transepithelial chloride transport; CC: chloride channel complex, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BGT0
Entrez ID: 14628
|
Does Knockout of Kcnrg in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Kcnrg
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Kcnrg (potassium channel regulator)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of delayed rectifier potassium channel activity. Predicted to be active in endoplasmic reticulum. Orthologous to human KCNRG (potassium channel regulator). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of delayed rectifier potassium channel activity, protein homooligomerization; MF: identical protein binding; CC: endoplasmic reticulum
Pathways:
UniProt: Q2TUM3
Entrez ID: 328424
|
Does Knockout of Arpp19 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Arpp19
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Arpp19 (cAMP-regulated phosphoprotein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, mitotic cell cycle, positive regulation of gluconeogenesis; MF: phosphatase inhibitor activity, potassium channel regulator activity, protein phosphatase 2A binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, signaling receptor binding; CC: cytoplasm, cytosol, dendrite, synapse
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, MASTL Facilitates Mitotic Progression, Mitotic Prophase
UniProt: P56212
Entrez ID: 59046
|
Does Knockout of Peli3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Peli3
|
phagocytosis
|
macrophage
|
Gene: Peli3 (pellino 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to Gram-negative bacterium, immune system process, innate immune response, negative regulation of Toll signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, negative regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of type I interferon production, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein K63-linked ubiquitination, protein polyubiquitination, protein ubiquitination, regulation of Toll signaling pathway, regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity
Pathways: Cytokine Signaling in Immune system, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Signaling by Interleukins, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q8BXR6
Entrez ID: 240518
|
Does Knockout of Ccdc177 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Ccdc177
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc177 (coiled-coil domain containing 177)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UHB8
Entrez ID: 380768
|
Does Knockout of Twf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Twf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Twf2 (twinfilin actin binding protein 2)
Type: protein-coding
Summary: Enables actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping. Located in several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament depolymerization, barbed-end actin filament capping, cell projection organization, cellular response to growth factor stimulus, cellular response to retinoic acid, intracellular signal transduction, negative regulation of actin filament polymerization, positive regulation of axon extension, positive regulation of lamellipodium assembly, positive regulation of neuron projection development, regulation of actin cytoskeleton organization, regulation of lamellipodium assembly, regulation of microvillus length; MF: ATP binding, actin binding, actin filament binding, actin monomer binding, phosphatidylinositol-4,5-bisphosphate binding, protein kinase C binding; CC: actin filament, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, growth cone, lamellipodium, myofibril, perinuclear region of cytoplasm, stereocilium
Pathways:
UniProt: Q9Z0P5
Entrez ID: 23999
|
Does Knockout of Kank3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Kank3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kank3 (KN motif and ankyrin repeat domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of actin filament polymerization, negative regulation of stress fiber assembly, podocyte cell migration, regulation of Rho protein signal transduction; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q9Z1P7
Entrez ID: 80880
|
Does Knockout of Tmem33 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tmem33
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem33 (transmembrane protein 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum tubular network organization, immune system process, innate immune response, membrane organization, positive regulation of IRE1-mediated unfolded protein response, positive regulation of PERK-mediated unfolded protein response, regulation of endoplasmic reticulum tubular network organization, response to endoplasmic reticulum stress; CC: endoplasmic reticulum, endoplasmic reticulum membrane, melanosome, membrane, nuclear envelope, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9CR67
Entrez ID: 67878
|
Does Knockout of Smim22 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Smim22
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Smim22 (small integral membrane protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid droplet formation, positive regulation of cell migration, regulation of actin cytoskeleton organization, regulation of cell cycle, regulation of cell population proliferation; CC: cellular_component, membrane
Pathways:
UniProt: V9GXA9, J3QP37
Entrez ID: 432995
|
Does Knockout of Aadac in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Aadac
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Aadac (arylacetamide deacetylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, positive regulation of triglyceride catabolic process; MF: carboxylic ester hydrolase activity, catalytic activity, deacetylase activity, hydrolase activity, lipase activity, serine hydrolase activity, triacylglycerol lipase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q99PG0
Entrez ID: 67758
|
Does Knockout of Zfp956 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Zfp956
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zfp956 (zinc finger protein 956)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q4VA54, Q3UZY6, Q8BR38, D6RE39
Entrez ID: 101197
|
Does Knockout of Lrp8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Lrp8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ammon gyrus development, cellular response to cholesterol, cellular response to growth factor stimulus, cerebral cortex development, chemical synaptic transmission, dendrite morphogenesis, endocytosis, hippocampus development, layer formation in cerebral cortex, modulation of chemical synaptic transmission, nervous system development, positive regulation of dendrite development, positive regulation of dendritic spine morphogenesis, reelin-mediated signaling pathway, regulation of apoptotic process, regulation of innate immune response, response to xenobiotic stimulus, ventral spinal cord development; MF: amyloid-beta binding, apolipoprotein binding, calcium ion binding, calcium-dependent protein binding, high-density lipoprotein particle binding, kinesin binding, low-density lipoprotein particle receptor activity, metal ion binding, protein binding, reelin receptor activity, very-low-density lipoprotein particle receptor activity; CC: Schaffer collateral - CA1 synapse, axon, caveola, cell surface, dendrite, extracellular region, extracellular space, glutamatergic synapse, membrane, microtubule associated complex, neuronal cell body, plasma membrane, postsynaptic density membrane, receptor complex
Pathways: Hemostasis, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Platelet homeostasis, Platelet sensitization by LDL, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction
UniProt: Q924X6
Entrez ID: 16975
|
Does Knockout of Dhx58 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Dhx58
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dhx58 (DExH-box helicase 58)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, immune system process, innate immune response, negative regulation of MDA-5 signaling pathway, negative regulation of RIG-I signaling pathway, negative regulation of innate immune response, negative regulation of type I interferon production, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production, regulation of innate immune response, response to bacterium, response to virus; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, metal ion binding, nucleotide binding, single-stranded RNA binding, zinc ion binding; CC: cytoplasm
Pathways: RIG-I-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q99J87
Entrez ID: 80861
|
Does Knockout of Trim35 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Trim35
|
phagocytosis
|
macrophage
|
Gene: Trim35 (tripartite motif-containing 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, innate immune response, negative regulation of cell population proliferation, negative regulation of mitotic cell cycle, positive regulation of apoptotic process, positive regulation of myeloid cell apoptotic process, protein ubiquitination, suppression of viral release by host; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8C006
Entrez ID: 66854
|
Does Knockout of GM20481 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
GM20481
|
phagocytosis
|
macrophage
|
Gene: Gm20481 (predicted gene 20481)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Rin3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Rin3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rin3 (Ras and Rab interactor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of mast cell chemotaxis, negative regulation of receptor internalization, regulation of vesicle size, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, small GTPase binding; CC: axon, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, early endosome, endocytic vesicle, endosome, neuronal cell body, vesicle
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: P59729
Entrez ID: 217835
|
Does Knockout of Fosb in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Fosb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fosb (FBJ osteosarcoma oncogene B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to cocaine, cellular response to calcium ion, cellular response to hormone stimulus, female pregnancy, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to amphetamine, response to cAMP, response to cocaine, response to corticosterone, response to ethanol, response to mechanical stimulus, response to morphine, response to nicotine, response to progesterone, response to xenobiotic stimulus, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse)
UniProt: P13346
Entrez ID: 14282
|
Does Knockout of Snx22 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Snx22
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Snx22 (sorting nexin 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein transport; MF: lipid binding, molecular_function, phosphatidylinositol binding, phosphatidylinositol phosphate binding; CC: cellular_component, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane
Pathways:
UniProt: Q8C084
Entrez ID: 382083
|
Does Knockout of Tspo2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Tspo2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tspo2 (translocator protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 5-aminolevulinic acid import across plasma membrane, enucleate erythrocyte differentiation, import across plasma membrane, intracellular cholesterol transport, lipid droplet organization; MF: 5-aminolevulinic acid transmembrane transporter activity, cholesterol binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, organelle membrane, plasma membrane
Pathways:
UniProt: Q9CRZ8
Entrez ID: 70026
|
Does Knockout of Usp32 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Usp32
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Usp32 (ubiquitin specific peptidase 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of TORC1 signaling, protein deubiquitination, proteolysis; MF: calcium ion binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, intracellular component, recycling endosome
Pathways:
UniProt: F8VPZ3
Entrez ID: 237898
|
Does Knockout of Atp8b2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Atp8b2
|
response to bacteria
|
renal medulla cell line
|
Gene: Atp8b2 (ATPase, class I, type 8B, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylcholine flippase activity, phosphatidylcholine floppase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, phospholipid-translocating ATPase complex, plasma membrane, trans-Golgi network
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: P98199
Entrez ID: 54667
|
Does Knockout of Nuak2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Nuak2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nuak2 (NUAK family, SNF1-like kinase, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, apoptotic process, cellular response to glucose starvation, negative regulation of apoptotic process, protein localization to nucleus, protein phosphorylation, regulation of hippo signaling; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: Q8BZN4
Entrez ID: 74137
|
Does Knockout of Casp7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Casp7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Casp7 (caspase 7)
Type: protein-coding
Summary: Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity. Involved in lymphocyte apoptotic process and protein maturation. Acts upstream of or within several processes, including ceramide biosynthetic process; fibroblast apoptotic process; and plasma membrane repair. Is active in extracellular space. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, cellular response to lipopolysaccharide, cellular response to staurosporine, ceramide biosynthetic process, defense response to bacterium, execution phase of apoptosis, fibroblast apoptotic process, heart development, leukocyte apoptotic process, lymphocyte apoptotic process, negative regulation of transcription by RNA polymerase II, neuron apoptotic process, plasma membrane repair, positive regulation of canonical NF-kappaB signal transduction, positive regulation of neuron apoptotic process, positive regulation of plasma membrane repair, protein catabolic process, protein maturation, protein poly-ADP-ribosylation, protein processing, proteolysis, pyroptotic inflammatory response, regulation of transcription by RNA polymerase II, response to UV, striated muscle cell differentiation; MF: RNA binding, aspartic-type endopeptidase activity, catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, cytosol, extracellular region, extracellular space, fibrillar center, nucleoplasm, nucleus, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: P97864
Entrez ID: 12369
|
Does Knockout of Scnn1b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Scnn1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scnn1b (sodium channel, nonvoltage-gated 1 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aldosterone metabolic process, artery smooth muscle contraction, blood circulation, cellular response to acidic pH, cellular response to aldosterone, cellular response to vasopressin, epithelial fluid transport, erythrocyte homeostasis, gene expression, inflammatory response, intracellular sodium ion homeostasis, leukocyte activation involved in inflammatory response, lung alveolus development, monoatomic ion transmembrane transport, monoatomic ion transport, mucus secretion, multicellular organism growth, multicellular organismal-level water homeostasis, neutrophil activation involved in immune response, neutrophil-mediated killing of bacterium, potassium ion homeostasis, regulation of blood pressure, regulation of body fluid levels, regulation of sodium ion transport, renal system process, response to food, response to xenobiotic stimulus, sensory perception of salty taste, sensory perception of sour taste, sodium ion homeostasis, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport, wound healing, spreading of epidermal cells; MF: WW domain binding, ligand-gated sodium channel activity, protein binding, sodium channel activity, sodium ion transmembrane transporter activity; CC: apical plasma membrane, cell surface, cytoplasmic vesicle, cytoplasmic vesicle membrane, external side of plasma membrane, extracellular exosome, membrane, plasma membrane, sodium channel complex
Pathways: Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Ion channel transport, Sensory Perception, Sensory perception of salty taste, Sensory perception of taste, Stimuli-sensing channels, Taste transduction - Mus musculus (mouse), Transport of small molecules
UniProt: Q9WU38
Entrez ID: 20277
|
Does Knockout of Arl10 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 1
| 1,839
|
Knockout
|
Arl10
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Arl10 (ADP-ribosylation factor-like 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding
Pathways:
UniProt: Q9QXJ4
Entrez ID: 56795
|
Does Knockout of Naa15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Naa15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Naa15 (N(alpha)-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell differentiation, negative regulation of apoptotic process, positive regulation of DNA-templated transcription, protein stabilization; MF: N-acetyltransferase activity, acetyltransferase activator activity, acetyltransferase activity, protein binding, ribosome binding; CC: NatA complex, cytoplasm, cytosol, nuclear body, nucleus, perinuclear region of cytoplasm, transcription regulator complex
Pathways:
UniProt: A0A0A6YX86, G3X8Y3, A0A0A6YW80, A0A0A6YXF4
Entrez ID: 74838
|
Does Knockout of Arhgef39 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Arhgef39
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Arhgef39 (Rho guanine nucleotide exchange factor 39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell migration; CC: membrane, plasma membrane
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q66JY6
Entrez ID: 230098
|
Does Knockout of Cd209g in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Cd209g
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cd209g (CD209g antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, pattern recognition receptor activity
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: D3Z5D4
Entrez ID: 70192
|
Does Knockout of Scrn3 in Non-Small Cell Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,189
|
Knockout
|
Scrn3
|
tumorigenicity
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: Scrn3 (secernin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of temperature stimulus involved in sensory perception of pain, proteolysis; MF: cysteine-type exopeptidase activity, dipeptidase activity, molecular_function
Pathways:
UniProt: Q3TMH2
Entrez ID: 74616
|
Does Knockout of Uchl5 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Uchl5
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Uchl5 (ubiquitin carboxyl-terminal esterase L5)
Type: protein-coding
Summary: Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including brain development; positive regulation of DNA metabolic process; and telomere maintenance. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex and cytosolic proteasome complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and salivary gland primordium. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin remodeling, forebrain morphogenesis, lateral ventricle development, midbrain development, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of smoothened signaling pathway, positive regulation of telomere maintenance in response to DNA damage, protein deubiquitination, proteolysis, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of proteasomal protein catabolic process, telomere maintenance, ubiquitin-dependent protein catabolic process; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, endopeptidase inhibitor activity, hydrolase activity, peptidase activity, proteasome binding; CC: Ino80 complex, cytoplasm, cytosol, cytosolic proteasome complex, nucleolus, nucleoplasm, nucleus, proteasome complex
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q9WUP7
Entrez ID: 56207
|
Does Knockout of Gm20904 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm20904
|
phagocytosis
|
macrophage
|
Gene: Gm20904 (predicted gene, 20904)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ociad2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Ociad2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ociad2 (OCIA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, mitochondrial respiratory chain complex III assembly, response to bacterium; CC: endosome, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9D8W7
Entrez ID: 433904
|
Does Knockout of Lsm10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Lsm10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lsm10 (U7 snRNP-specific Sm-like protein LSM10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: RNA binding, U7 snRNA binding, histone pre-mRNA DCP binding, snRNA binding; CC: Cajal body, U7 snRNP, cytoplasmic U snRNP body, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8QZX5
Entrez ID: 116748
|
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